Proto-oncogene FBI-1 (Pokemon) and SREBP-1 synergistically activate transcription of fatty-acid synthase gene (FASN).

PubMed

Choi, Won-Il; Jeon, Bu-Nam; Park, Hyejin; Yoo, Jung-Yoon; Kim, Yeon-Sook; Koh, Dong-In; Kim, Myung-Hwa; Kim, Yu-Ri; Lee, Choong-Eun; Kim, Kyung-Sup; Osborne, Timothy F; Hur, Man-Wook

2008-10-24

FBI-1 (Pokemon/ZBTB7A) is a proto-oncogenic transcription factor of the BTB/POZ (bric-à-brac, tramtrack, and broad complex and pox virus zinc finger) domain family. Recent evidence suggested that FBI-1 might be involved in adipogenic gene expression. Coincidentally, expression of FBI-1 and fatty-acid synthase (FASN) genes are often increased in cancer and immortalized cells. Both FBI-1 and FASN are important in cancer cell proliferation. SREBP-1 is a major regulator of many adipogenic genes, and FBI-1 and SREBP-1 (sterol-responsive element (SRE)-binding protein 1) interact with each other directly via their DNA binding domains. FBI-1 enhanced the transcriptional activation of SREBP-1 on responsive promoters, pGL2-6x(SRE)-Luc and FASN gene. FBI-1 and SREBP-1 synergistically activate transcription of the FASN gene by acting on the proximal GC-box and SRE/E-box. FBI-1, Sp1, and SREBP-1 can bind to all three SRE, GC-box, and SRE/E-box. Binding competition among the three transcription factors on the GC-box and SRE/E-box appears important in the transcription regulation. FBI-1 is apparently changing the binding pattern of Sp1 and SREBP-1 on the two elements in the presence of induced SREBP-1 and drives more Sp1 binding to the proximal promoter with less of an effect on SREBP-1 binding. The changes induced by FBI-1 appear critical in the synergistic transcription activation. The molecular mechanism revealed provides insight into how proto-oncogene FBI-1 may attack the cellular regulatory mechanism of FASN gene expression to provide more phospholipid membrane components needed for rapid cancer cell proliferation.

The Modified Frontal Behavioral Inventory (FBI-mod) for Patients with Frontotemporal Lobar Degeneration, Alzheimer's Disease, and Mild Cognitive Impairment.

PubMed

Suhonen, Noora-Maria; Hallikainen, Ilona; Hänninen, Tuomo; Jokelainen, Jari; Krüger, Johanna; Hall, Anette; Pikkarainen, Maria; Soininen, Hilkka; Remes, Anne M

2017-01-01

While behavioral symptoms are both early and prevalent features of behavioral variant frontotemporal dementia (bvFTD), they can be present in other types of dementia as well, including Alzheimer's disease (AD) and even mild cognitive impairment (MCI). The Frontal Behavioral Inventory (FBI) was specifically developed to capture the behavioral and personality changes in bvFTD; it has also been modified into a self-administered caregiver questionnaire (FBI-mod). We examined the utility of the FBI-mod in differentiating bvFTD (n = 26), primary progressive aphasia (PPA) (n = 7), AD (n = 53), and MCI (n = 50) patients, and investigated how the FBI-mod may be associated with neuropsychological measures. The bvFTD patients scored significantly higher as compared to all other patient groups on the FBI-mod Total (p < 0.005), Negative (p < 0.005), and Positive (p < 0.01) scores. The cut-off point for the FBI-mod Total score that best discriminated the bvFTD and AD patients in our sample was 16, thus substantially lower than reported for the original FBI. For the bvFTD group, only mild correlations emerged between the FBI-mod and the cognitive measures. However, significant correlations between the FBI-mod and depressive symptoms as measured by the BDI-II were found for bvFTD. This suggests that while behavioral symptoms appear independent from cognitive deficits in bvFTD, they may nevertheless be interrelated with depressive symptoms. We conclude that the FBI-mod is an easily administered behavioral scale that can aid in differential diagnosis of bvFTD and should be used in clinical practice. The FBI-mod may further be considered as an outcome measure in clinical trials.

FBI-1 promotes cell proliferation and enhances resistance to chemotherapy of hepatocellular carcinoma in vitro and in vivo.

PubMed

Fang, Feng; Yang, Lianyue; Tao, Yiming; Qin, Wei

2012-01-01

The so-called factor that binds to inducer of short transcripts-1 (FBI-1) purportedly plays an important role in tumorigenesis; however, its role in hepatocellular carcinoma (HCC) remains unknown. The objective of this study was to investigate the expression level, clinical relevance, and biologic function of FBI-1 in HCC. Real-time quantitative reverse transcriptase-polymerase chain reaction analysis, Western blot analysis, and immunohistochemical staining were used to detect expression levels of FBI-1 and to analyze its relation to clinicopathologic parameters and to the prognosis of patients with HCC. In addition, the biologic functions of FBI-1 in regulating cell proliferation, migration, and reaction to chemotherapy were detected by using HepG2 cells and SMMC-7721 cells; subsequently, the molecular mechanism of FBI-1 also was investigated. Finally, a xenograft mouse model was used to validate the observations obtained from in vitro studies. Expression levels of FBI-1 messenger RNA and protein were elevated significantly in HCC tissues compared with adjacent nontumorous liver tissues (ANLTs). Increased FBI-1 expression was correlated with multiple tumor nodes, Edmondson-Steiner grade, and a poor prognosis in patients with HCC (P < .05). In vitro studies revealed that FBI-1 was capable of promoting cell proliferation (but not cell migration) by regulating the cell cycle regulation proteins p53, p21, and p27. In addition, FBI-1 could inhibit cell death induced by 5-fluorouracil or doxorubicin through suppressing the activation of p53. Consistent with the in vitro data, FBI-1 was capable of promoting cell proliferation and enhancing chemotherapy resistance of HCC in vivo. The current findings indicated that FBI-1 plays an important role in HCC carcinogenesis and chemotherapy tolerance, and FBI-1 may served as a novel prognostic marker and therapeutic target for HCC. Copyright © 2011 American Cancer Society.

The transcription factor FBI-1 inhibits SAM68-mediated BCL-X alternative splicing and apoptosis.

PubMed

Bielli, Pamela; Busà, Roberta; Di Stasi, Savino M; Munoz, Manuel J; Botti, Flavia; Kornblihtt, Alberto R; Sette, Claudio

2014-04-01

Alternative splicing (AS) is tightly coupled to transcription for the majority of human genes. However, how these two processes are linked is not well understood. Here, we unveil a direct role for the transcription factor FBI-1 in the regulation of AS. FBI-1 interacts with the splicing factor SAM68 and reduces its binding to BCL-X mRNA. This, in turn, results in the selection of the proximal 5' splice site in BCL-X exon 2, thereby favoring the anti-apoptotic BCL-XL variant and counteracting SAM68-mediated apoptosis. Conversely, depletion of FBI-1, or expression of a SAM68 mutant lacking the FBI-1 binding region, restores the ability of SAM68 to induce BCL-XS splicing and apoptosis. FBI-1's role in splicing requires the activity of histone deacetylases, whose pharmacological inhibition recapitulates the effects of FBI-1 knockdown. Our study reveals an unexpected function for FBI-1 in splicing modulation with a direct impact on cell survival.

The transcription factor FBI-1 inhibits SAM68-mediated BCL-X alternative splicing and apoptosis

PubMed Central

Bielli, Pamela; Busà, Roberta; Di Stasi, Savino M; Munoz, Manuel J; Botti, Flavia; Kornblihtt, Alberto R; Sette, Claudio

2014-01-01

Alternative splicing (AS) is tightly coupled to transcription for the majority of human genes. However, how these two processes are linked is not well understood. Here, we unveil a direct role for the transcription factor FBI-1 in the regulation of AS. FBI-1 interacts with the splicing factor SAM68 and reduces its binding to BCL-X mRNA. This, in turn, results in the selection of the proximal 5′ splice site in BCL-X exon 2, thereby favoring the anti-apoptotic BCL-XL variant and counteracting SAM68-mediated apoptosis. Conversely, depletion of FBI-1, or expression of a SAM68 mutant lacking the FBI-1 binding region, restores the ability of SAM68 to induce BCL-XS splicing and apoptosis. FBI-1's role in splicing requires the activity of histone deacetylases, whose pharmacological inhibition recapitulates the effects of FBI-1 knockdown. Our study reveals an unexpected function for FBI-1 in splicing modulation with a direct impact on cell survival. PMID:24514149

Overexpression of proto-oncogene FBI-1 activates membrane type 1-matrix metalloproteinase in association with adverse outcome in ovarian cancers.

PubMed

Jiang, Lili; Siu, Michelle K Y; Wong, Oscar G W; Tam, Kar Fai; Lam, Eric W-F; Ngan, Hextan Y S; Le, Xiao-Feng; Wong, Esther S Y; Chan, Hoi Yan; Cheung, Annie N Y

2010-12-21

FBI-1 (factor that binds to the inducer of short transcripts of human immunodeficiency virus-1) is a member of the POK (POZ and Kruppel) family of transcription factors and play important roles in cellular differentiation and oncogenesis. Recent evidence suggests that FBI-1 is expressed at high levels in a subset of human lymphomas and some epithelial solid tumors. However, the function of FBI-1 in human ovarian cancers remains elusive. In this study, we investigated the role of FBI-1 in human ovarian cancers, in particularly, its function in cancer cell invasion via modulating membrane type 1-matrix metalloproteinase (MT1-MMP). Significantly higher FBI-1 protein and mRNA expression levels were demonstrated in ovarian cancers samples and cell lines compared with borderline tumors and benign cystadenomas. Increased FBI-1 mRNA expression was correlated significantly with gene amplification (P = 0.037). Moreover, higher FBI-1 expression was found in metastatic foci (P = 0.036) and malignant ascites (P = 0.021), and was significantly associated with advanced stage (P = 0.012), shorter overall survival (P = 0.032) and disease-free survival (P = 0.016). In vitro, overexpressed FBI-1 significantly enhanced cell migration and invasion both in OVCA 420 and SKOV-3 ovarian carcinoma cells, irrespective of p53 status, accompanied with elevated expression of MT1-MMP, but not MMP-2 or TIMP-2. Moreover, knockdown of MT1-MMP abolished FBI-1-mediated cell migration and invasion. Conversely, stable knockdown of FBI-1 remarkably reduced the motility of these cells with decreased expression of MT1-MMP. Promoter assay and chromatin immunoprecipitation study indicated that FBI-1 could directly interact with the promoter spanning ~600 bp of the 5'-flanking sequence of MT1-MMP and enhanced its expression in a dose-dependent manner. Furthermore, stable knockdown and ectopic expression of FBI-1 decreased and increased cell proliferation respectively in OVCA 420, but not in the p53 null SKOV-3 cells. Our results suggested an important role of FBI-1 in ovarian cancer cell proliferation, cell mobility, and invasiveness, and that FBI-1 can be a potential target of chemotherapy.

Overexpression of proto-oncogene FBI-1 activates membrane type 1-matrix metalloproteinase in association with adverse outcome in ovarian cancers

PubMed Central

2010-01-01

Background FBI-1 (factor that binds to the inducer of short transcripts of human immunodeficiency virus-1) is a member of the POK (POZ and Kruppel) family of transcription factors and play important roles in cellular differentiation and oncogenesis. Recent evidence suggests that FBI-1 is expressed at high levels in a subset of human lymphomas and some epithelial solid tumors. However, the function of FBI-1 in human ovarian cancers remains elusive. Results In this study, we investigated the role of FBI-1 in human ovarian cancers, in particularly, its function in cancer cell invasion via modulating membrane type 1-matrix metalloproteinase (MT1-MMP). Significantly higher FBI-1 protein and mRNA expression levels were demonstrated in ovarian cancers samples and cell lines compared with borderline tumors and benign cystadenomas. Increased FBI-1 mRNA expression was correlated significantly with gene amplification (P = 0.037). Moreover, higher FBI-1 expression was found in metastatic foci (P = 0.036) and malignant ascites (P = 0.021), and was significantly associated with advanced stage (P = 0.012), shorter overall survival (P = 0.032) and disease-free survival (P = 0.016). In vitro, overexpressed FBI-1 significantly enhanced cell migration and invasion both in OVCA 420 and SKOV-3 ovarian carcinoma cells, irrespective of p53 status, accompanied with elevated expression of MT1-MMP, but not MMP-2 or TIMP-2. Moreover, knockdown of MT1-MMP abolished FBI-1-mediated cell migration and invasion. Conversely, stable knockdown of FBI-1 remarkably reduced the motility of these cells with decreased expression of MT1-MMP. Promoter assay and chromatin immunoprecipitation study indicated that FBI-1 could directly interact with the promoter spanning ~600bp of the 5'-flanking sequence of MT1-MMP and enhanced its expression in a dose-dependent manner. Furthermore, stable knockdown and ectopic expression of FBI-1 decreased and increased cell proliferation respectively in OVCA 420, but not in the p53 null SKOV-3 cells. Conclusions Our results suggested an important role of FBI-1 in ovarian cancer cell proliferation, cell mobility, and invasiveness, and that FBI-1 can be a potential target of chemotherapy. PMID:21176152

Comparison of imaging value for diabetic lower extremity arterial disease between FBI and CE-MRA.

PubMed

Yi, C-Y; Zhou, D-X; Li, H-H; Wang, Y; Chen, K; Chen, J; Huang, B-C; Xu, X-L

2016-07-01

This study adopted self-control study method to assess the efficacy of fresh blood imaging (FBI) and contrast-enhanced MR angiography (CE-MRA) for patients with diabetic lower extremity arterial disease (DLEAD) (Fontaine stage I to IV), and to evaluate the imaging of lower extremity peripheral arterial disease (PAD) in different stages of diabetes mellitus (DM). 1. This study recruited 44 diabetic patients with suspected lower extremity PAD to take both FBI and CE-MRA. 2. Two experienced cardiovascular radiologists assessed the image quality, the detection of lower extremity arterial branches, and tissue contamination (veins, arteries, and soft tissues) of FBI and CE-MRA, as well as the presence and severity of stenotic lesions. 3. Statistical differences of the quality of FBI and CE-MRA were determined using paired t-test. 4. Correlation analysis was adopted for determining the direction and strength of the relationship between the changes of the indexes of FBI and the different Fontaine stages. 1. The quality evaluation results of the image of lower extremity arteries from the 44 diabetic patients indicated no statistically significant difference between FBI and CE-MRA in the patients with Fontaine stage I-III (p >0.05). However, a statistically significant difference was observed in the patients with Fontaine stage IV (p <0.05), and the quality of FBI was slightly worse. 2. Arterial branches that observed from FBI and CE-MRA were 885 and 904, respectively. There was no statistically significant difference for the arterial branches between FBI and CE-MRA in the patients with Fontaine stage I-III (p >0.05). However, a statistically significant difference was observed in the patients with Fontaine stage IV (p <0.05), and CE-MRA indicated more artery branches than FBI. 3. There was a statistically significant difference for the evaluation of venous contamination between FBI and CE-MRA (p <0.05), and there was less venous contamination using FBI. 4. The study results indicated that with Fontaine stages going on the FBI's image quality and arterial branches reduced gradually, and the degree of tissue interference and arteriostenosis was rising gradually. The results of this study indicated that using FBI in lower extremity PAD of diabetics had good quality and high diagnostic accurancy, and the tissue contamination (veins and soft tissues of calf) was effectively avoided. Especially in Fontaine stage I-III, FBI can be used as an alternative technique of CE-MRA, and it also can be used in diabetic patients with renal impairment in Fontaine IV.

Eukaryotic translation initiator protein 1A isoform, CCS-3, enhances the transcriptional repression of p21CIP1 by proto-oncogene FBI-1 (Pokemon/ZBTB7A).

PubMed

Choi, Won-Il; Kim, Youngsoo; Kim, Yuri; Yu, Mi-young; Park, Jungeun; Lee, Choong-Eun; Jeon, Bu-Nam; Koh, Dong-In; Hur, Man-Wook

2009-01-01

FBI-1, a member of the POK (POZ and Kruppel) family of transcription factors, plays a role in differentiation, oncogenesis, and adipogenesis. eEF1A is a eukaryotic translation elongation factor involved in several cellular processes including embryogenesis, oncogenic transformation, cell proliferation, and cytoskeletal organization. CCS-3, a potential cervical cancer suppressor, is an isoform of eEF1A. We found that eEF1A forms a complex with FBI-1 by co-immunoprecipitation, SDS-PAGE, and MALDI-TOF Mass analysis of the immunoprecipitate. GST fusion protein pull-downs showed that FBI-1 directly interacts with eEF1A and CCS-3 via the zinc finger and POZ-domain of FBI-1. FBI-1 co-localizes with either eEF1A or CCS-3 at the nuclear periplasm. CCS-3 enhances transcriptional repression of the p21CIP1 gene (hereafter referred to as p21) by FBI-1. The POZ-domain of FBI-1 interacts with the co-repressors, SMRT and BCoR. We found that CCS-3 also interacts with the co-repressors independently. The molecular interaction between the co-repressors and CCS-3 at the POZ-domain of FBI-1 appears to enhance FBI-1 mediated transcriptional repression. Our data suggest that CCS-3 may be important in cell differentiation, tumorigenesis, and oncogenesis by interacting with the proto-oncogene FBI-1 and transcriptional co-repressors. Copyright 2009 S. Karger AG, Basel.

Differentiating the frontal variant of Alzheimer's disease.

PubMed

Woodward, Michael; Jacova, Claudia; Black, Sandra E; Kertesz, Andrew; Mackenzie, Ian R; Feldman, Howard

2010-07-01

Individuals with a clinical diagnosis of Alzheimer's disease (AD) may have prominent features of executive dysfunction and language impairment as well as behavioral abnormalities early in the disease ('high frontality'). When this occurs differentiation from frontotemporal dementia (FTD) is difficult. It is hypothesized that AD patients with high frontality may have clinical and pathological features that distinguish them from less frontal AD patients. In a well-characterized cohort of people with cognitive impairment, we used the Frontal Behavioral Inventory (FBI) in an attempt to identify AD patients with prominent frontal features (high-FBI AD) and distinguish them from the remainder of AD patients (low-FBI AD). The 18 high-FBI AD patients were compared with the 26 FTD patients who had an FBI performed and the 53 other low FBI AD patients. The individual FBI items did not differ significantly between the FTD and the high-FBI AD patients, and the high FBI AD patients were more like the FTD patients than the other AD patients with respect to presence of a family history of AD, proportion with homozygous apolipoprotein E(4) status, disability as measured by the Disability Assessment for Dementia (DAD) Scale and the Functional Rating Scale (FRS) and neuropsychiatric impairment as measured by the Neuropsychiatric Inventory (NPI). Memory symptom duration was similar in the high FBI AD group compared to the low FBI AD group. There is a subgroup of AD patients with high frontality that can be clinically distinguished from the remainder of AD patients but which requires pathological verification. (c) 2009 John Wiley & Sons, Ltd.

The FBI Vs. Domestic Terrorism.

ERIC Educational Resources Information Center

Webster, William H.

1984-01-01

Describes the efforts of the FBI to combat terrorism. Contingency plans have been established in each FBI field office, and agents are receiving special training in hostage rescue. Psycholinguistics is being used to deduce information about unknown terrorists. In 1982 the FBI arrested 95 terrorist suspects and obtained 84 convictions. (CS)

78 FR 13085 - Proposed Collection, Comments Requested: FBI National Academy Level 1 Evaluation: Student Course...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-26

..., Comments Requested: FBI National Academy Level 1 Evaluation: Student Course Questionnaire and FBI National Academy: General Remarks Questionnaire ACTION: 60-day notice. The Department of Justice (DOJ), Federal... Evaluation: Student Course Questionnaire FBI National Academy: General Remarks Questionnaire. 3. Agency Form...

78 FR 26396 - Proposed Collection; Comments Requested: FBI National Academy Level 1 Evaluation: Student Course...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-06

... Academy Level 1 Evaluation: Student Course Questionnaire and FBI National Academy: General Remarks Questionnaire ACTION: 30-Day Notice. The Department of Justice (DOJ), Federal Bureau of Investigation (FBI...: Student Course Questionnaire. FBI National Academy: General Remarks Questionnaire. 3. Agency Form Number...

49 CFR 1572.403 - Procedures for collection by States.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Threat Assessment Fee and the FBI Fee. (a) Imposition of fees. (1) An individual who applies to obtain or... FBI Fee, in a form and manner approved by TSA and the State, when the individual submits the... other applicable Federal law. (3) The FBI Fee required for the FBI to process fingerprint identification...

28 CFR 8.10 - Remission or mitigation of forfeiture.

Code of Federal Regulations, 2010 CFR

2010-07-01

....10 Section 8.10 Judicial Administration DEPARTMENT OF JUSTICE FBI FORFEITURE AUTHORITY FOR CERTAIN... of the FBI and shall be filed in triplicate with the Special Agent in Charge of the FBI field office... General of the United States and filed in triplicate with the Special Agent in Charge of the FBI field...

28 CFR 8.10 - Remission or mitigation of forfeiture.

Code of Federal Regulations, 2011 CFR

2011-07-01

....10 Section 8.10 Judicial Administration DEPARTMENT OF JUSTICE FBI FORFEITURE AUTHORITY FOR CERTAIN... of the FBI and shall be filed in triplicate with the Special Agent in Charge of the FBI field office... General of the United States and filed in triplicate with the Special Agent in Charge of the FBI field...

49 CFR 1572.403 - Procedures for collection by States.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Threat Assessment Fee and the FBI Fee. (a) Imposition of fees. (1) An individual who applies to obtain or... FBI Fee, in a form and manner approved by TSA and the State, when the individual submits the... other applicable Federal law. (3) The FBI Fee required for the FBI to process fingerprint identification...

28 CFR 8.10 - Remission or mitigation of forfeiture.

Code of Federal Regulations, 2012 CFR

2012-07-01

....10 Section 8.10 Judicial Administration DEPARTMENT OF JUSTICE FBI FORFEITURE AUTHORITY FOR CERTAIN... of the FBI and shall be filed in triplicate with the Special Agent in Charge of the FBI field office... General of the United States and filed in triplicate with the Special Agent in Charge of the FBI field...

76 FR 55332 - Federal Bureau of Investigation Anti-Piracy Warning Seal Program

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-07

... Investigation Anti-Piracy Warning Seal Program AGENCY: Federal Bureau of Investigation (FBI), Justice. ACTION... general authorization for use of the FBI Anti- Piracy Warning Seal (APW Seal). The proposed rule will... period closes. Discussion. The FBI's Anti-Piracy Warning (APW) Seal is a modified image of the FBI's...

77 FR 40539 - Privacy Act of 1974; Implementation

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-10

..., JUSTICE/FBI- 022, the FBI Data Warehouse System. In this notice of proposed rulemaking, the FBI proposes... FR 53342 (Aug. 31, 2010) and modified at 75 FR 66131 (Oct. 27, 2010) because the Data Warehouse... proposes to exempt the Data Warehouse System, Justice/FBI-022, from certain provisions of the Privacy Act...

Non-contrast enhanced MR venography using 3D fresh blood imaging (FBI): initial experience.

PubMed

Yokoyama, K; Nitatori, T; Inaoka, S; Takahara, T; Hachiya, J

2001-01-01

This study examined the efficacy of 3D-fresh blood imaging (FBI) in patients with venous disease in the iliac region to lower extremity. Fourteen patients with venous disease were examined [8 deep venous thrombosis (DVT) and 6 varix] by 3D-FBI and 2D-TOF MRA. All FBI images and 2D-TOF images were evaluated in terms of visualization of the disease and compared with conventional X-ray venography (CV). The total scan time of 3D-FBI ranged from 3 min 24 sec to 4 min 52 sec. 3D-FBI was positive in all 23 anatomical levels in which DVT was diagnosed by CV (100% sensitivity) as well as 2D-TOF. The delineation of collateral veins was superior or equal to that of 2D-TOF. 3D-FBI allowed depiction of varices in five of six cases; however, in one case, the evaluation was limited because the separation of arteries from veins was difficult. The 3D-FBI technique, which allows iliac to peripheral MR venography without contrast medium within a short acquisition time, is considered clinically useful.

Sagittal fresh blood imaging with interleaved acquisition of systolic and diastolic data for improved robustness to motion.

PubMed

Atanasova, Iliyana P; Kim, Daniel; Storey, Pippa; Rosenkrantz, Andrew B; Lim, Ruth P; Lee, Vivian S

2013-02-01

To improve robustness to patient motion of "fresh blood imaging" (FBI) for lower extremity noncontrast MR angiography. In FBI, two sets of three-dimensional fast spin echo images are acquired at different cardiac phases and subtracted to generate bright-blood angiograms. Routinely performed with a single coronal slab and sequential acquisition of systolic and diastolic data, FBI is prone to subtraction errors due to patient motion. In this preliminary feasibility study, FBI was implemented with two sagittal imaging slabs, and the systolic and diastolic acquisitions were interleaved to minimize sensitivity to motion. The proposed technique was evaluated in volunteers and patients. In 10 volunteers, imaged while performing controlled movements, interleaved FBI demonstrated better tolerance to subject motion than sequential FBI. In one patient with peripheral arterial disease, interleaved FBI offered better depiction of collateral flow by reducing sensitivity to inadvertent motion. FBI with interleaved acquisition of diastolic and systolic data in two sagittal imaging slabs offers improved tolerance to patient motion. Copyright © 2013 Wiley Periodicals, Inc.

Sagittal Fresh Blood Imaging with Interleaved Acquisition of Systolic and Diastolic Data for Improved Robustness to Motion

PubMed Central

Atanasova, Iliyana P.; Kim, Daniel; Storey, Pippa; Rosenkrantz, Andrew B; Lim, Ruth P.; Lee, Vivian S.

2012-01-01

Purpose To improve robustness to patient motion of ‘fresh blood imaging’ (FBI) for lower extremity non-contrast MRA. Methods In FBI, two sets of 3D fast spin echo images are acquired at different cardiac phases and subtracted to generate bright-blood angiograms. Routinely performed with a single coronal slab and sequential acquisition of systolic and diastolic data, FBI is prone to subtraction errors due to patient motion. In this preliminary feasibility study, FBI was implemented with two sagittal imaging slabs, and the systolic and diastolic acquisitions were interleaved to minimize sensitivity to motion. The proposed technique was evaluated in volunteers and patients. Results In ten volunteers, imaged while performing controlled movements, interleaved FBI demonstrated better tolerance to subject motion than sequential FBI. In one patient with peripheral arterial disease, interleaved FBI offered better depiction of collateral flow by reducing sensitivity to inadvertent motion. Conclusions FBI with interleaved acquisition of diastolic and systolic data in two sagittal imaging slabs offers improved tolerance to patient motion. PMID:23300129

Prevalence of Eosinophilic Esophagitis and Lymphocytic Esophagitis in Adults with Esophageal Food Bolus Impaction.

PubMed

Truskaite, Kotryna; Dlugosz, Aldona

2016-01-01

Background. The relation of esophageal food bolus impaction (FBI) to eosinophilic esophagitis (EoE) and lymphocytic esophagitis (LyE) is unclear. The aim of this study was to determine the prevalence of EoE and LyE among adults with FBI. Methods. In this retrospective study we analyzed data from all patients referred for gastroscopy during the past 5 years, because of a present or recent episode of FBI. Results. We found 238 patients with FBI (median age 51 (17-96), 71% males). Endoscopic therapy was required in 143 patients. Esophageal biopsies were obtained in 185 (78%) patients. All biopsies were assessed for numbers of eosinophils and lymphocytes. EoE was found in 18% of patients who underwent biopsy. We found 41 patients (22%) who fulfilled the criteria for both EoE and LyE (EoE/LyE). LyE was found in the 9% of patients with FBI. EoE together with EoE/LyE was the leading cause of FBI in patients ≤50 years (64%). GERD was the leading cause of FBI among patients older than 50 years (42%). Conclusions. Our study showed that EoE was the leading cause of FBI in particular among young adults. Our study highlights the need for esophageal biopsies in any patient with FBI.

Proto-oncogene FBI-1 (Pokemon/ZBTB7A) represses transcription of the tumor suppressor Rb gene via binding competition with Sp1 and recruitment of co-repressors.

PubMed

Jeon, Bu-Nam; Yoo, Jung-Yoon; Choi, Won-Il; Lee, Choong-Eun; Yoon, Ho-Geun; Hur, Man-Wook

2008-11-28

FBI-1 (also called Pokemon/ZBTB7A) is a BTB/POZ-domain Krüppel-like zinc-finger transcription factor. Recently, FBI-1 was characterized as a proto-oncogenic protein, which represses tumor suppressor ARF gene transcription. The expression of FBI-1 is increased in many cancer tissues. We found that FBI-1 potently represses transcription of the Rb gene, a tumor suppressor gene important in cell cycle arrest. FBI-1 binds to four GC-rich promoter elements (FREs) located at bp -308 to -188 of the Rb promoter region. The Rb promoter also contains two Sp1 binding sites: GC-box 1 (bp -65 to -56) and GC-box 2 (bp -18 to -9), the latter of which is also bound by FBI-1. We found that FRE3 (bp -244 to -236) is also a Sp1 binding element. FBI-1 represses transcription of the Rb gene not only by binding to the FREs, but also by competing with Sp1 at the GC-box 2 and the FRE3. By binding to the FREs and/or the GC-box, FBI-1 represses transcription of the Rb gene through its POZ-domain, which recruits a co-repressor-histone deacetylase complex and deacetylates histones H3 and H4 at the Rb gene promoter. FBI-1 inhibits C2C12 myoblast cell differentiation by repressing Rb gene expression.

The proto-oncoprotein FBI-1 interacts with MBD3 to recruit the Mi-2/NuRD-HDAC complex and BCoR and to silence p21WAF/CDKN1A by DNA methylation.

PubMed

Choi, Won-Il; Jeon, Bu-Nam; Yoon, Jae-Hyeon; Koh, Dong-In; Kim, Myung-Hwa; Yu, Mi-Young; Lee, Kyung-Mi; Kim, Youngsoo; Kim, Kyunggon; Hur, Sujin Susanne; Lee, Choong-Eun; Kim, Kyung-Sup; Hur, Man-Wook

2013-07-01

The tumour-suppressor gene CDKN1A (encoding p21Waf/Cip1) is thought to be epigenetically repressed in cancer cells. FBI-1 (ZBTB7A) is a proto-oncogenic transcription factor repressing the alternative reading frame and p21WAF/CDKN1A genes of the p53 pathway. FBI-1 interacts directly with MBD3 (methyl-CpG-binding domain protein 3) in the nucleus. We demonstrated that FBI-1 binds both non-methylated and methylated DNA and that MBD3 is recruited to the CDKN1A promoter through its interaction with FBI-1, where it enhances transcriptional repression by FBI-1. FBI-1 also interacts with the co-repressors nuclear receptor corepressor (NCoR), silencing mediator for retinoid and thyroid receptors (SMRT) and BCL-6 corepressor (BCoR) to repress transcription. MBD3 regulates a molecular interaction between the co-repressor and FBI-1. MBD3 decreases the interaction between FBI-1 and NCoR/SMRT but increases the interaction between FBI-1 and BCoR. Because MBD3 is a subunit of the Mi-2 autoantigen (Mi-2)/nucleosome remodelling and histone deacetylase (NuRD)-HDAC complex, FBI-1 recruits the Mi-2/NuRD-HDAC complex via MBD3. BCoR interacts with the Mi-2/NuRD-HDAC complex, DNMTs and HP1. MBD3 and BCoR play a significant role in the recruitment of the Mi-2/NuRD-HDAC complex- and the NuRD complex-associated proteins, DNMTs and HP. By recruiting DNMTs and HP1, Mi-2/NuRD-HDAC complex appears to play key roles in epigenetic repression of CDKN1A by DNA methylation.

Proto-oncogene FBI-1 represses transcription of p21CIP1 by inhibition of transcription activation by p53 and Sp1.

PubMed

Choi, Won-Il; Jeon, Bu-Nam; Yun, Chae-Ok; Kim, Pyung-Hwan; Kim, Sung-Eun; Choi, Kang-Yell; Kim, Se Hoon; Hur, Man-Wook

2009-05-08

Aberrant transcriptional repression through chromatin remodeling and histone deacetylation has been postulated as the driving force for tumorigenesis. FBI-1 (formerly called Pokemon) is a member of the POK family of transcriptional repressors. Recently, FBI-1 was characterized as a critical oncogenic factor that specifically represses transcription of the tumor suppressor gene ARF, potentially leading indirectly to p53 inactivation. Our investigations on transcriptional repression of the p53 pathway revealed that FBI-1 represses transcription of ARF, Hdm2 (human analogue of mouse double minute oncogene), and p21CIP1 (hereafter indicated as p21) but not of p53. FBI-1 showed a more potent repressive effect on p21 than on p53. Our data suggested that FBI-1 is a master controller of the ARF-Hdm2-p53-p21 pathway, ultimately impinging on cell cycle arrest factor p21, by inhibiting upstream regulators at the transcriptional and protein levels. FBI-1 acted as a competitive transcriptional repressor of p53 and Sp1 and was shown to bind the proximal Sp1-3 GC-box and the distal p53-responsive elements of p21. Repression involved direct binding competition of FBI-1 with Sp1 and p53. FBI-1 also interacted with corepressors, such as mSin3A, NCoR, and SMRT, thereby deacetylating Ac-H3 and Ac-H4 histones at the promoter. FBI-1 caused cellular transformation, promoted cell cycle proliferation, and significantly increased the number of cells in S phase. FBI-1 is aberrantly overexpressed in many human solid tumors, particularly in adenocarcinomas and squamous carcinomas. The role of FBI-1 as a master controller of the p53 pathway therefore makes it an attractive therapeutic target.

Proto-oncogene FBI-1 Represses Transcription of p21CIP1 by Inhibition of Transcription Activation by p53 and Sp1*S⃞

PubMed Central

Choi, Won-Il; Jeon, Bu-Nam; Yun, Chae-Ok; Kim, Pyung-Hwan; Kim, Sung-Eun; Choi, Kang-Yell; Kim, Se Hoon; Hur, Man-Wook

2009-01-01

Aberrant transcriptional repression through chromatin remodeling and histone deacetylation has been postulated as the driving force for tumorigenesis. FBI-1 (formerly called Pokemon) is a member of the POK family of transcriptional repressors. Recently, FBI-1 was characterized as a critical oncogenic factor that specifically represses transcription of the tumor suppressor gene ARF, potentially leading indirectly to p53 inactivation. Our investigations on transcriptional repression of the p53 pathway revealed that FBI-1 represses transcription of ARF, Hdm2 (human analogue of mouse double minute oncogene), and p21CIP1 (hereafter indicated as p21) but not of p53. FBI-1 showed a more potent repressive effect on p21 than on p53. Our data suggested that FBI-1 is a master controller of the ARF-Hdm2-p53-p21 pathway, ultimately impinging on cell cycle arrest factor p21, by inhibiting upstream regulators at the transcriptional and protein levels. FBI-1 acted as a competitive transcriptional repressor of p53 and Sp1 and was shown to bind the proximal Sp1–3 GC-box and the distal p53-responsive elements of p21. Repression involved direct binding competition of FBI-1 with Sp1 and p53. FBI-1 also interacted with corepressors, such as mSin3A, NCoR, and SMRT, thereby deacetylating Ac-H3 and Ac-H4 histones at the promoter. FBI-1 caused cellular transformation, promoted cell cycle proliferation, and significantly increased the number of cells in S phase. FBI-1 is aberrantly overexpressed in many human solid tumors, particularly in adenocarcinomas and squamous carcinomas. The role of FBI-1 as a master controller of the p53 pathway therefore makes it an attractive therapeutic target. PMID:19244234

28 CFR 513.11 - Procedures for requesting a FBI identification record or a NCIC/III record.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Procedures for requesting a FBI..., DEPARTMENT OF JUSTICE GENERAL MANAGEMENT AND ADMINISTRATION ACCESS TO RECORDS Production or Disclosure of FBI/NCIC Information § 513.11 Procedures for requesting a FBI identification record or a NCIC/III record...

28 CFR 0.89a - Delegations respecting claims against the FBI.

Code of Federal Regulations, 2012 CFR

2012-07-01

... FBI. 0.89a Section 0.89a Judicial Administration DEPARTMENT OF JUSTICE ORGANIZATION OF THE DEPARTMENT OF JUSTICE Federal Bureau of Investigation § 0.89a Delegations respecting claims against the FBI. (a... FBI or his designee within the Office of the General Counsel or to the primary legal advisors of the...

28 CFR 513.11 - Procedures for requesting a FBI identification record or a NCIC/III record.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Procedures for requesting a FBI..., DEPARTMENT OF JUSTICE GENERAL MANAGEMENT AND ADMINISTRATION ACCESS TO RECORDS Production or Disclosure of FBI/NCIC Information § 513.11 Procedures for requesting a FBI identification record or a NCIC/III record...

28 CFR 27.3 - Investigations: The Department of Justice's Office of Professional Responsibility and Office of...

Code of Federal Regulations, 2013 CFR

2013-07-01

... FBI employee who believes that another employee of the FBI, or of any other Departmental component... subpart, references to the FBI include any other Departmental component in which the person or persons... Receiving Offices, in the absence of a reprisal allegation by an FBI employee under this part, from...

28 CFR 27.3 - Investigations: The Department of Justice's Office of Professional Responsibility and Office of...

Code of Federal Regulations, 2014 CFR

2014-07-01

... FBI employee who believes that another employee of the FBI, or of any other Departmental component... subpart, references to the FBI include any other Departmental component in which the person or persons... Receiving Offices, in the absence of a reprisal allegation by an FBI employee under this part, from...

28 CFR 0.89a - Delegations respecting claims against the FBI.

Code of Federal Regulations, 2014 CFR

2014-07-01

... FBI. 0.89a Section 0.89a Judicial Administration DEPARTMENT OF JUSTICE ORGANIZATION OF THE DEPARTMENT OF JUSTICE Federal Bureau of Investigation § 0.89a Delegations respecting claims against the FBI. (a... FBI or his designee within the Office of the General Counsel or to the primary legal advisors of the...

49 CFR 1572.403 - Procedures for collection by States.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Threat Assessment Fee and the FBI Fee. (a) Imposition of fees. (1) The following Threat Assessment Fee is... applies to obtain or renew an HME: $34. (2) The following FBI Fee is required for the FBI to process... FBI under Pub. L. 101-515. (3) An individual who applies to obtain or renew an HME, or the individual...

49 CFR 1572.403 - Procedures for collection by States.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Threat Assessment Fee and the FBI Fee. (a) Imposition of fees. (1) The following Threat Assessment Fee is... applies to obtain or renew an HME: $34. (2) The following FBI Fee is required for the FBI to process... FBI under Pub. L. 101-515. (3) An individual who applies to obtain or renew an HME, or the individual...

28 CFR 513.11 - Procedures for requesting a FBI identification record or a NCIC/III record.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Procedures for requesting a FBI..., DEPARTMENT OF JUSTICE GENERAL MANAGEMENT AND ADMINISTRATION ACCESS TO RECORDS Production or Disclosure of FBI/NCIC Information § 513.11 Procedures for requesting a FBI identification record or a NCIC/III record...

28 CFR 0.89a - Delegations respecting claims against the FBI.

Code of Federal Regulations, 2013 CFR

2013-07-01

... FBI. 0.89a Section 0.89a Judicial Administration DEPARTMENT OF JUSTICE ORGANIZATION OF THE DEPARTMENT OF JUSTICE Federal Bureau of Investigation § 0.89a Delegations respecting claims against the FBI. (a... FBI or his designee within the Office of the General Counsel or to the primary legal advisors of the...

49 CFR 1572.403 - Procedures for collection by States.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Threat Assessment Fee and the FBI Fee. (a) Imposition of fees. (1) The following Threat Assessment Fee is... applies to obtain or renew an HME: $34. (2) The following FBI Fee is required for the FBI to process... FBI under Pub. L. 101-515. (3) An individual who applies to obtain or renew an HME, or the individual...

28 CFR 513.11 - Procedures for requesting a FBI identification record or a NCIC/III record.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Procedures for requesting a FBI..., DEPARTMENT OF JUSTICE GENERAL MANAGEMENT AND ADMINISTRATION ACCESS TO RECORDS Production or Disclosure of FBI/NCIC Information § 513.11 Procedures for requesting a FBI identification record or a NCIC/III record...

28 CFR 27.3 - Investigations: The Department of Justice's Office of Professional Responsibility and Office of...

Code of Federal Regulations, 2012 CFR

2012-07-01

... FBI employee who believes that another employee of the FBI, or of any other Departmental component... subpart, references to the FBI include any other Departmental component in which the person or persons... Receiving Offices, in the absence of a reprisal allegation by an FBI employee under this part, from...

28 CFR 0.89a - Delegations respecting claims against the FBI.

Code of Federal Regulations, 2011 CFR

2011-07-01

... FBI. 0.89a Section 0.89a Judicial Administration DEPARTMENT OF JUSTICE ORGANIZATION OF THE DEPARTMENT OF JUSTICE Federal Bureau of Investigation § 0.89a Delegations respecting claims against the FBI. (a... authorized to redelegate to the General Counsel of the FBI or his designee within the Office of the General...

76 FR 65781 - Request for Applications for the IRS Advisory Committee on Tax Exempt and Government Entities

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-24

... Date(s) (required for FBI check); Date of Birth (required for FBI check); City and State of Birth (required for FBI Check); Current Address; Telephone and Fax Numbers; and e-mail address, if any... things, pre-appointment and annual tax checks, and an FBI criminal and subversive name check, fingerprint...

28 CFR 27.3 - Investigations: The Department of Justice's Office of Professional Responsibility and Office of...

Code of Federal Regulations, 2011 CFR

2011-07-01

... FBI employee who believes that another employee of the FBI, or of any other Departmental component... subpart, references to the FBI include any other Departmental component in which the person or persons... Receiving Offices, in the absence of a reprisal allegation by an FBI employee under this part, from...

28 CFR 0.89a - Delegations respecting claims against the FBI.

Code of Federal Regulations, 2010 CFR

2010-07-01

... FBI. 0.89a Section 0.89a Judicial Administration DEPARTMENT OF JUSTICE ORGANIZATION OF THE DEPARTMENT OF JUSTICE Federal Bureau of Investigation § 0.89a Delegations respecting claims against the FBI. (a... authorized to redelegate to the General Counsel of the FBI or his designee within the Office of the General...

28 CFR 513.11 - Procedures for requesting a FBI identification record or a NCIC/III record.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Procedures for requesting a FBI..., DEPARTMENT OF JUSTICE GENERAL MANAGEMENT AND ADMINISTRATION ACCESS TO RECORDS Production or Disclosure of FBI/NCIC Information § 513.11 Procedures for requesting a FBI identification record or a NCIC/III record...

Proto-oncogene FBI-1 (Pokemon/ZBTB7A) Represses Transcription of the Tumor Suppressor Rb Gene via Binding Competition with Sp1 and Recruitment of Co-repressors*S⃞

PubMed Central

Jeon, Bu-Nam; Yoo, Jung-Yoon; Choi, Won-Il; Lee, Choong-Eun; Yoon, Ho-Geun; Hur, Man-Wook

2008-01-01

FBI-1 (also called Pokemon/ZBTB7A) is a BTB/POZ-domain Krüppel-like zinc-finger transcription factor. Recently, FBI-1 was characterized as a proto-oncogenic protein, which represses tumor suppressor ARF gene transcription. The expression of FBI-1 is increased in many cancer tissues. We found that FBI-1 potently represses transcription of the Rb gene, a tumor suppressor gene important in cell cycle arrest. FBI-1 binds to four GC-rich promoter elements (FREs) located at bp –308 to –188 of the Rb promoter region. The Rb promoter also contains two Sp1 binding sites: GC-box 1 (bp –65 to –56) and GC-box 2 (bp –18 to –9), the latter of which is also bound by FBI-1. We found that FRE3 (bp –244 to –236) is also a Sp1 binding element. FBI-1 represses transcription of the Rb gene not only by binding to the FREs, but also by competing with Sp1 at the GC-box 2 and the FRE3. By binding to the FREs and/or the GC-box, FBI-1 represses transcription of the Rb gene through its POZ-domain, which recruits a co-repressor-histone deacetylase complex and deacetylates histones H3 and H4 at the Rb gene promoter. FBI-1 inhibits C2C12 myoblast cell differentiation by repressing Rb gene expression. PMID:18801742

Deep vein thrombosis using noncontrast-enhanced MR venography with electrocardiographically gated three-dimensional half-Fourier FSE: preliminary experience.

PubMed

Ono, Atsushi; Murase, Kenya; Taniguchi, Toshitaka; Shibutani, Osamu; Takata, Satoru; Kobashi, Yasuyuki; Miyazaki, Mitsue

2009-04-01

Three noncontrast-enhanced MR venography techniques are presented for assessing deep vein thrombosis (DVT) at 0.5 T in patients with metallic implants. Two cardiac-gated 3D half-Fourier FSE fresh blood imaging sequences with flow-refocusing pulses (FR-FBI) in the read-out (RO) direction and without FR pulses (non-FR-FBI) were developed for slower-flowing blood. For faster flowing blood, a swap phase-encode arterial double-subtraction elimination (SPADE) technique was developed. The three techniques were assessed both quantitatively using signal-to-noise (SNR) and contrast-noise-ratio (CNR) measurements and qualitatively by subjective image analysis in 15 volunteers. SPADE was compared to FR-FBI in the pelvic veins and FR-FBI was compared to non-FR-FBI in the thigh and calf veins. Both SPADE and FR-FBI techniques produced significantly higher SNRs, CNRs, and image quality in each comparative study (P<0.001). Five patients with metallic implants and confirmed DVT underwent SPADE (pelvic veins) and FR-FBI (thigh and calf veins) examinations and the results were compared to conventional venography. The SPADE and FR-FBI images showed all DVTs from all five patients without interference from implant susceptibility artifacts. The excellent image quality produced by both SPADE and FR-FBI throughout peripheral vasculature demonstrates their promise for detecting DVT in postsurgery patients.

28 CFR 27.4 - Corrective action and other relief; Director, Office of Attorney Recruitment and Management.

Code of Federal Regulations, 2011 CFR

2011-07-01

... action, the Director shall provide an opportunity for comments on the report by the FBI and the... considers appropriate. The Director shall allow the FBI an opportunity to comment to the Director on any... action. The Director shall notify the FBI of the receipt of the request and allow the FBI 25 calendar...

78 FR 60378 - Request for Applications for the IRS Advisory Committee on Tax Exempt and Government Entities

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-01

... letter with the following information: Name; Other Name(s) Used and Date(s) (required for FBI check); Date of Birth (required for FBI check); City and State of Birth (required for FBI Check); Current..., among other things, pre-appointment and annual tax checks, and an FBI criminal and subversive name check...

77 FR 60026 - Request for Applications for the IRS Advisory Committee on Tax Exempt and Government Entities

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-01

...(s) Used and Date(s) (required for FBI check); Date of Birth (required for FBI check); City and State of Birth (required for FBI Check); Current Address; Telephone and Fax Numbers; and email address, if... process includes, among other things, pre-appointment and annual tax checks, and an FBI criminal and...

28 CFR 0.157 - Federal Bureau of Investigation-Drug Enforcement Administration Senior Executive Service.

Code of Federal Regulations, 2012 CFR

2012-07-01

... within the Federal Bureau of Investigation (FBI) and the Drug Enforcement Administration (DEA) to be known as the FBI-DEA Senior Executive Service (FBI-DEA SES). (b) Pursuant to 5 U.S.C. 3151(b)(2)(B), a... the position of Deputy Director of the FBI (which remains subject to the exclusive authority of the...

75 FR 66431 - Request for Applications for the IRS Advisory Committee on Tax Exempt and Government Entities

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-28

...) Used and Date(s) (required for FBI check); Date of Birth (required for FBI check); City and State of Birth (required for FBI Check); Current Address; Telephone and Fax Numbers; and e-mail address, if any... process includes, among other things, pre-appointment and annual tax checks, and an FBI criminal and...

28 CFR 27.4 - Corrective action and other relief; Director, Office of Attorney Recruitment and Management.

Code of Federal Regulations, 2013 CFR

2013-07-01

... action, the Director shall provide an opportunity for comments on the report by the FBI and the... considers appropriate. The Director shall allow the FBI an opportunity to comment to the Director on any... action. The Director shall notify the FBI of the receipt of the request and allow the FBI 25 calendar...

28 CFR 0.157 - Federal Bureau of Investigation-Drug Enforcement Administration Senior Executive Service.

Code of Federal Regulations, 2011 CFR

2011-07-01

... within the Federal Bureau of Investigation (FBI) and the Drug Enforcement Administration (DEA) to be known as the FBI-DEA Senior Executive Service (FBI-DEA SES). (b) Pursuant to 5 U.S.C. 3151(b)(2)(B), a... the position of Deputy Director of the FBI (which remains subject to the exclusive authority of the...

28 CFR 0.157 - Federal Bureau of Investigation-Drug Enforcement Administration Senior Executive Service.

Code of Federal Regulations, 2013 CFR

2013-07-01

... within the Federal Bureau of Investigation (FBI) and the Drug Enforcement Administration (DEA) to be known as the FBI-DEA Senior Executive Service (FBI-DEA SES). (b) Pursuant to 5 U.S.C. 3151(b)(2)(B), a... the position of Deputy Director of the FBI (which remains subject to the exclusive authority of the...

28 CFR 0.157 - Federal Bureau of Investigation-Drug Enforcement Administration Senior Executive Service.

Code of Federal Regulations, 2014 CFR

2014-07-01

... within the Federal Bureau of Investigation (FBI) and the Drug Enforcement Administration (DEA) to be known as the FBI-DEA Senior Executive Service (FBI-DEA SES). (b) Pursuant to 5 U.S.C. 3151(b)(2)(B), a... the position of Deputy Director of the FBI (which remains subject to the exclusive authority of the...

28 CFR 27.4 - Corrective action and other relief; Director, Office of Attorney Recruitment and Management.

Code of Federal Regulations, 2012 CFR

2012-07-01

... action, the Director shall provide an opportunity for comments on the report by the FBI and the... considers appropriate. The Director shall allow the FBI an opportunity to comment to the Director on any... action. The Director shall notify the FBI of the receipt of the request and allow the FBI 25 calendar...

28 CFR 27.4 - Corrective action and other relief; Director, Office of Attorney Recruitment and Management.

Code of Federal Regulations, 2014 CFR

2014-07-01

... action, the Director shall provide an opportunity for comments on the report by the FBI and the... considers appropriate. The Director shall allow the FBI an opportunity to comment to the Director on any... action. The Director shall notify the FBI of the receipt of the request and allow the FBI 25 calendar...

Developing the Interstate Identification Index/Federal Bureau of Investigation (III/FBI) system for providing timely criminal and civil identification and criminal history information to the nation's law enforcement agencies

NASA Astrophysics Data System (ADS)

Copeland, Patricia L.; Shugars, James

1997-02-01

The Federal Bureau of Investigation (FBI) is currently developing a new system to provide timely criminal and civil identities and criminal history information to the nation's local, state, and federal users. The Integrated Automated Fingerprint Identification System (IAFIS), an upgrade to the existing Identification Division Automated Services (IDAS) System, is scheduled for implementation in 1999 at the new FBI facility in Clarksburg, West Virginia. IAFIS will offer new capabilities for electronic transmittal of fingerprint cards to the FBI, an improved fingerprint matching algorithm, and electronic maintenance of fingerprints and photo images. The Interstate Identification Index (III/FBI) System is one of three segments comprising the umbrella IAFIS System. III/FBI provides repository, maintenance, and dissemination capabilities for the 40 million subject national criminal history database. III/FBI will perform over 1 million name searches each day. Demanding performance, reliability/maintainability/availability, and flexibility/expandability requirements make III/FBI an architectural challenge to the system developers. This paper will discuss these driving requirements and present the technical solutions in terms of leading edge hardware and software.

[Peripheral MR angiography without contrast agent using fresh blood imaging (FBI) with ECG-trigger: initial experience].

PubMed

Xia, Chun-Chao; Li, Zhen-Lin; Chen, Xian; Sun, Jia-Yu; Li, Chang-Xian; Tang, He-Han; Yuan, Yuan; Song, Bin

2012-07-01

To examine the efficacy of fresh blood imaging (FBI) in detecting vascular diseases in lower extremity. Thirty-six patients suspected of having lower extremity vascular diseases were imaged with a 1.5-T MRI system (Toshiba Excelart Vantage). Contrast-enhanced MRA (CEMRA) and FBI technology, with maximum intensity projection (MIP) reconstruction were adopted to visualize lower extremity vascular. Signal to noise ratios (SNR) were measured on the FBI and CEMRA images. Two experienced radiologists assessed the imaging quality of peripheral artery MRA on MIP reconstructed images. All patients successfully underwent both FBI and CEMRA. All arterial segments were obtained in the 36 patients. The SNR values on FBI and CEMRA were 108.39 +/- 9.76 and 87.46 +/- 14.77 (t = - 6.782, P = 0.001), respectively. There were no significant differences in the overall image quality, arterial anatomy and venous overlap (chi2 = 0.004, P = 0.947; chi2 = 0.000, P = 1; chi2 = 0.681, P = 0.409). The CEMRA motion artifacts were less than FBI (chi2 = 8.744, P = 0.03). The FBI technique, which shows the vascular disease in lower extremity without contrast medium with ECG gating, is considered clinically useful.

The Frontal Behavioural Inventory (Italian version) differentiates frontotemporal lobar degeneration variants from Alzheimer's disease.

PubMed

Alberici, A; Geroldi, C; Cotelli, M; Adorni, A; Calabria, M; Rossi, G; Borroni, B; Padovani, A; Zanetti, O; Kertesz, A

2007-04-01

The objective was to evaluate the construct validity of the Italian version of the Frontal Behavioural Inventory (FBI) and its usefulness in the differential diagnosis of dementias. Standard criteria were used in the clinical diagnosis of dementias in 83 patients and 33 agematched healthy volunteers. The FBI scale was translated from English into Italian language and back-translated. Cronbach's alpha, inter-rater and test-retest reliability, FBI convergent validity and discriminant analysis were calculated. FBI profile was compared between patients affected by frontotemporal lobar degeneration (FTLD) and Alzheimer's disease (AD). The FBI showed a high internal consistency and inter-rater reliability and it distinguished normal behavioural conditions from those presented in FTLD or AD. An 86.8% diagnostic accuracy was calculated by the discriminant analysis, selecting only age at disease onset and FBI, and particularly distinguishing behavioural variants within the FTLD spectrum. FTLD patients showed a characteristic behavioural profile. The FBI might be a reliable and useful diagnostic tool for dementias in clinical practice.

The proto-oncoprotein FBI-1 interacts with MBD3 to recruit the Mi-2/NuRD-HDAC complex and BCoR and to silence p21WAF/CDKN1A by DNA methylation

PubMed Central

Choi, Won-Il; Jeon, Bu-Nam; Yoon, Jae-Hyeon; Koh, Dong-In; Kim, Myung-Hwa; Yu, Mi-Young; Lee, Kyung-Mi; Kim, Youngsoo; Kim, Kyunggon; Hur, Sujin Susanne; Lee, Choong-Eun; Kim, Kyung-Sup; Hur, Man-Wook

2013-01-01

The tumour-suppressor gene CDKN1A (encoding p21Waf/Cip1) is thought to be epigenetically repressed in cancer cells. FBI-1 (ZBTB7A) is a proto-oncogenic transcription factor repressing the alternative reading frame and p21WAF/CDKN1A genes of the p53 pathway. FBI-1 interacts directly with MBD3 (methyl-CpG–binding domain protein 3) in the nucleus. We demonstrated that FBI-1 binds both non-methylated and methylated DNA and that MBD3 is recruited to the CDKN1A promoter through its interaction with FBI-1, where it enhances transcriptional repression by FBI-1. FBI-1 also interacts with the co-repressors nuclear receptor corepressor (NCoR), silencing mediator for retinoid and thyroid receptors (SMRT) and BCL-6 corepressor (BCoR) to repress transcription. MBD3 regulates a molecular interaction between the co-repressor and FBI-1. MBD3 decreases the interaction between FBI-1 and NCoR/SMRT but increases the interaction between FBI-1 and BCoR. Because MBD3 is a subunit of the Mi-2 autoantigen (Mi-2)/nucleosome remodelling and histone deacetylase (NuRD)-HDAC complex, FBI-1 recruits the Mi-2/NuRD-HDAC complex via MBD3. BCoR interacts with the Mi-2/NuRD-HDAC complex, DNMTs and HP1. MBD3 and BCoR play a significant role in the recruitment of the Mi-2/NuRD-HDAC complex– and the NuRD complex–associated proteins, DNMTs and HP. By recruiting DNMTs and HP1, Mi-2/NuRD-HDAC complex appears to play key roles in epigenetic repression of CDKN1A by DNA methylation. PMID:23658227

EPAS-1 mediates SP-1-dependent FBI-1 expression and regulates tumor cell survival and proliferation.

PubMed

Wang, Xiaogang; Cao, Peng; Li, Zhiqing; Wu, Dongyang; Wang, Xi; Liang, Guobiao

2014-09-04

Factor binding IST-1 (FBI-1) plays an important role in oncogenic transformation and tumorigenesis. As FBI-1 is over-expressed in multiple human cancers, the regulation of itself would provide new effective options for cancer intervention. In this work, we aimed to study the role that EPAS-1 plays in regulating FBI-1. We use the fact that specificity protein-1 (SP-1) is one of the crucial transcription factors of FBI-1, and that SP-1 can interact with the endothelial pas domain protein-1 (EPAS-1) for the induction of hypoxia related genes. The study showed that EPAS-1 plays an indispensible role in SP-1 transcription factor-mediated FBI-1 induction, and participated in tumor cell survival and proliferation. Thus, EPAS-1 could be a novel target for cancer therapeutics.

FBI's Employee Assistance Program: an advanced law enforcement model.

PubMed

McNally, V J

1999-01-01

As we approach the 21st century the FBI has enhanced its Employee Assistance Program (EAP) to include EAP services, Peer Support and Critical Incident Stress Management/Debriefing (CISM/D) and Chaplains' Program. This EAP is now anticipating the future to include a Compassion Fatigue Program for its counselors and coordinators, as well as developing CISD protocols for incidents involving weapons of mass destruction. As the FBI has accepted new challenges in the investigative arena throughout the world, so the FBI's Employee Assistance and related programs have set out to support their employees and family members with a continuum of integrated confidential services. The FBI recognizes that its most important asset is its personnel, and EAP is the vehicle to assist the FBI family in remaining healthy and strong for the continuous quest to fulfill its mission.

A longitudinal study of behavior in frontotemporal dementia and primary progressive aphasia.

PubMed

Marczinski, Cecile A; Davidson, Wilda; Kertesz, Andrew

2004-12-01

To evaluate the construct validity of the Frontal Behavioral Inventory (FBI) and to describe the evolution of the behavioral abnormalities of the behavioral and aphasic presentations of frontotemporal dementia (FTD) by means of a 3-year longitudinal study. The FBI is a standardized behavioral questionnaire useful in the diagnosis and quantification of the personality and behavior disorder FTD. Patients who had three consecutive yearly assessments with the FBI were selected, 12 with the behavioral variant of FTD (FTD-bv) and 14 with Primary Progressive Aphasia (PPA). FBI scores rose as the disease progressed in both the FTD-bv and PPA groups over the 3 years of testing. Initial mean FBI scores of the FTD-bv group were above the cutoff for FTD as established for this diagnosis with previous standardization. By the third year, the mean FBI score of PPA patients was also above the established cutoff for FTD. The outcome of the study demonstrates that the FBI is sensitive to changes in behavior and personality in both variants of FTD. The FBI can be used to describe the evolution of symptoms and the course of the illness of Pick complex patients who present initially with FTD-bv or who present with PPA and subsequently develop the behavioral disorder.

Design of isolated buildings with S-FBI system subjected to near-fault earthquakes using NSGA-II algorithm

NASA Astrophysics Data System (ADS)

Ozbulut, O. E.; Silwal, B.

2014-04-01

This study investigates the optimum design parameters of a superelastic friction base isolator (S-FBI) system through a multi-objective genetic algorithm and performance-based evaluation approach. The S-FBI system consists of a flat steel- PTFE sliding bearing and a superelastic NiTi shape memory alloy (SMA) device. Sliding bearing limits the transfer of shear across the isolation interface and provides damping from sliding friction. SMA device provides restoring force capability to the isolation system together with additional damping characteristics. A three-story building is modeled with S-FBI isolation system. Multiple-objective numerical optimization that simultaneously minimizes isolation-level displacements and superstructure response is carried out with a genetic algorithm (GA) in order to optimize S-FBI system. Nonlinear time history analyses of the building with S-FBI system are performed. A set of 20 near-field ground motion records are used in numerical simulations. Results show that S-FBI system successfully control response of the buildings against near-fault earthquakes without sacrificing in isolation efficacy and producing large isolation-level deformations.

Appeals court says FBI erred in terminating doctor's services. Federal Bureau of Investigations.

PubMed

1995-09-22

The late Dr. [name removed] of San Francisco had a four-year contract to perform physical exams on local FBI agents and job applicants. When the FBI learned that Dr. [name removed] had AIDS, the San Francisco field office stopped using his services. An initial non-jury trial found that Dr. [name removed] did not have private right of action to sue the Federal government, and that his evasive answers as to his state of health and risk of transmission had prevented the FBI from learning the extent of risk. Upon appeal by Dr. [name removed]'s estate, however, a Federal court determined that the FBI had terminated Dr. [name removed] based on his HIV status, not on the quality of his work. The FBI's actions violated the 1973 Rehabilitation Act barring government-funded programs from discrimination based on disability.

EPAS-1 Mediates SP-1-Dependent FBI-1 Expression and Regulates Tumor Cell Survival and Proliferation

PubMed Central

Wang, Xiaogang; Cao, Peng; Li, Zhiqing; Wu, Dongyang; Wang, Xi; Liang, Guobiao

2014-01-01

Factor binding IST-1 (FBI-1) plays an important role in oncogenic transformation and tumorigenesis. As FBI-1 is over-expressed in multiple human cancers, the regulation of itself would provide new effective options for cancer intervention. In this work, we aimed to study the role that EPAS-1 plays in regulating FBI-1. We use the fact that specificity protein-1 (SP-1) is one of the crucial transcription factors of FBI-1, and that SP-1 can interact with the endothelial pas domain protein-1 (EPAS-1) for the induction of hypoxia related genes. The study showed that EPAS-1 plays an indispensible role in SP-1 transcription factor-mediated FBI-1 induction, and participated in tumor cell survival and proliferation. Thus, EPAS-1 could be a novel target for cancer therapeutics. PMID:25192290

Upscaling of fungal-bacterial interactions: from the lab to the field.

PubMed

de Boer, Wietse

2017-06-01

Fungal-bacterial interactions (FBI) are an integral component of microbial community networks in terrestrial ecosystems. During the last decade, the attention for FBI has increased tremendously. For a wide variety of FBI, information has become available on the mechanisms and functional responses. Yet, most studies have focused on pairwise interactions under controlled conditions. The question to what extent such studies are relevant to assess the importance of FBI for functioning of natural microbial communities in real ecosystems remains largely unanswered. Here, the information obtained by studying a type of FBI, namely antagonistic interactions between bacteria and plant pathogenic fungi, is discussed for different levels of community complexity. Based on this, general recommendations are given to integrate pairwise and ecosystem FBI studies. This approach could lead to the development of novel strategies to steer terrestrial ecosystem functioning. Copyright © 2017 Elsevier Ltd. All rights reserved.

First birth interval, an indicator of energetic status, is a predictor of lifetime reproductive strategy.

PubMed

Nenko, Ilona; Jasienska, Grazyna

2013-01-01

Women should differ in their reproductive strategies according to their nutritional status. We tested a hypothesis that women who have a good nutritional status early in life, as indicated by a shorter waiting time to the first birth (first birth interval, FBI), are able to afford higher costs of reproduction than women who have worse nutritional condition. We collected data on 377 women who got married between the years 1782 and 1882 in a natural fertility population in rural Poland. The study group was divided into tertiles based on the length of FBI. Women with the shortest FBI had a higher number of children (P = 0.005), higher number of sons (P = 0.01), and shorter mean interbirth intervals (P = 0.06). Women who had ever given birth to twins had shorter FBI than women of singletons (20.1 and 26.1 months, respectively; P = 0.049). Furthermore, women with a shorter FBI, despite having higher costs of reproduction, did not have a different lifespan than women with a longer FBI. Our results suggest that women who were in better energetic condition (shorter length of FBI), achieved higher reproductive success without reduction in lifespan. FBI reflects interindividual variation, which may result from variation in nutritional status early in life and thus may be a good predictor of subsequent reproductive strategy. We propose to use FBI as an indicator of women's nutritional status in studies of historical populations, especially when information about social status is not available. Copyright © 2012 Wiley Periodicals, Inc.

Role of the POZ zinc finger transcription factor FBI-1 in human and murine adipogenesis.

PubMed

Laudes, Matthias; Christodoulides, Constantinos; Sewter, Ciaran; Rochford, Justin J; Considine, Robert V; Sethi, Jaswinder K; Vidal-Puig, Antonio; O'Rahilly, Stephen

2004-03-19

Poxvirus zinc finger (POZ) zinc finger domain transcription factors have been shown to play a role in the control of growth arrest and differentiation in several types of mesenchymal cells but not, as yet, adipocytes. We found that a POZ domain protein, factor that binds to inducer of short transcripts-1 (FBI-1), was induced during both murine and human preadipocyte differentiation with maximal expression levels seen at days 2-4. FBI-1 mRNA was expressed in human adipose tissue with the highest levels found in samples from morbidly obese subjects. Murine cell lines constitutively expressing FBI-1 showed evidence for accelerated adipogenesis with earlier induction of markers of differentiation and enhanced lipid accumulation, suggesting that FBI-1 may be an active participant in the differentiation process. Consistent with the properties of this family of proteins in other cell systems, 3T3L1 cells stably overexpressing FBI-1 showed reduced DNA synthesis and reduced expression of cyclin A, cyclin-dependent kinase 2, and p107, proteins known to be involved in the regulation of mitotic clonal expansion. In addition, FBI-1 reduced the transcriptional activity of the cyclin A promoter. Thus, FBI-1, a POZ zinc finger transcription factor, is induced during the early phases of human and murine preadipocyte differentiation where it may contribute to adipogenesis through influencing the switch from cellular proliferation to terminal differentiation.

FBI-1 enhances transcription of the nuclear factor-kappaB (NF-kappaB)-responsive E-selectin gene by nuclear localization of the p65 subunit of NF-kappaB.

PubMed

Lee, Dong-Kee; Kang, Jae-Eun; Park, Hye-Jin; Kim, Myung-Hwa; Yim, Tae-Hee; Kim, Jung-Min; Heo, Min-Kyu; Kim, Kyu-Yeun; Kwon, Ho Jeong; Hur, Man-Wook

2005-07-29

The POZ domain is a highly conserved protein-protein interaction motif found in many regulatory proteins. Nuclear factor-kappaB (NF-kappaB) plays a key role in the expression of a variety of genes in response to infection, inflammation, and stressful conditions. We found that the POZ domain of FBI-1 (factor that binds to the inducer of short transcripts of human immunodeficiency virus-1) interacted with the Rel homology domain of the p65 subunit of NF-kappaB in both in vivo and in vitro protein-protein interaction assays. FBI-1 enhanced NF-kappaB-mediated transcription of E-selectin genes in HeLa cells upon phorbol 12-myristate 13-acetate stimulation and overcame gene repression by IkappaB alpha or IkappaB beta. In contrast, the POZ domain of FBI-1, which is a dominant-negative form of FBI-1, repressed NF-kappaB-mediated transcription, and the repression was cooperative with IkappaB alpha or IkappaB beta. In contrast, the POZ domain tagged with a nuclear localization sequence polypeptide of FBI-1 enhanced NF-kappaB-responsive gene transcription, suggesting that the molecular interaction between the POZ domain and the Rel homology domain of p65 and the nuclear localization by the nuclear localization sequence are important in the transcription enhancement mediated by FBI-1. Confocal microscopy showed that FBI-1 increased NF-kappaB movement into the nucleus and increased the stability of NF-kappaB in the nucleus, which enhanced NF-kappaB-mediated transcription of the E-selectin gene. FBI-1 also interacted with IkappaB alpha and IkappaB beta.

A comparative analysis of noncontrast flow-spoiled versus contrast-enhanced magnetic resonance angiography for evaluation of peripheral arterial disease.

PubMed

Kassamali, Rahil Hussein; Hoey, Edward T D; Ganeshan, Arul; Littlehales, Tracey

2013-01-01

This feasibility study aimed to obtain initial data to assess the performance of a novel noncontrast spoiled magnetic resonance (MR) angiography technique (fresh-blood imaging [FBI]) compared to gadolinium-enhanced MR (Gd-MR) angiography for evaluation of the aorto-iliac and lower extremity arteries. Thirteen patients with suspected lower extremity arterial disease that had undergone Gd-MR angiography and FBI at the same session were randomly included in the study. FBI was performed using an ECG-gated ow-spoiled T2-weighted half-Fourier fast spin-echo sequence. For analysis, the aortoiliac and lower limb arteries were divided into 18 anatomical segments. Two blinded readers individually graded image quality of FBI and also assessed the presence and severity of any stenotic lesions. A similar analysis was performed for the Gd-MR angiography images. A total of 385 arterial segments were analyzed; 34 segments were excluded due to degraded image quality (1.3% of Gd- MR vs. 8% of FBI-MR angiography images). FBI-MR angiography had comparable accuracy to Gd-MR angiography for assessment of the above knee vessels with high kappa statistics (large arteries, 0.91; small arteries, 0.86) and high sensitivity (large arteries, 98.1%; small arteries, 88.6%) and specificity (large arteries, 97.2%; small arteries, 97.6%) using Gd-MR angiography as the gold standard. Initial results show good agreement between FBI-MR angiography and Gd-MR angiography in the diagnosis of peripheral arterial disease, making FBI a potential alternative in patients with renal impairment. FBI showed highest accuracy in the above knee vessels. Technological refinements are required to improve accuracy for assessing the calf and pedal vessels.

FBI-1 Is Overexpressed in Gestational Trophoblastic Disease and Promotes Tumor Growth and Cell Aggressiveness of Choriocarcinoma via PI3K/Akt Signaling.

PubMed

Mak, Victor C Y; Wong, Oscar G W; Siu, Michelle K Y; Wong, Esther S Y; Ng, Wai-Yan; Wong, Richard W C; Chan, Ka-Kui; Ngan, Hextan Y S; Cheung, Annie N Y

2015-07-01

Human placental trophoblasts can be considered pseudomalignant, with tightly controlled proliferation, apoptosis, and invasiveness. Gestational trophoblastic disease (GTD) represents a family of heterogeneous trophoblastic lesions with aberrant apoptotic and proliferative activities and dysregulation of cell signaling pathways. We characterize the oncogenic effects of factor that binds to the inducer of short transcripts of HIV-1 [FBI-1, alias POZ and Krüppel erythroid myeloid ontogenic factor (POKEMON)/ZBTB7A] in GTD and its role in promoting cell aggressiveness in vitro and tumor growth in vivo. IHC studies showed increased nuclear expression of FBI-1, including hydatidiform moles, choriocarcinoma (CCA), and placental site trophoblastic tumor, in GTD. In JAR and JEG-3 CCA cells, ectopic FBI-1 expression opposed apoptosis through repression of proapoptotic genes (eg, BAK1, FAS, and CASP8). FBI-1 overexpression also promoted Akt activation, as indicated by Akt-pS473 phosphorylation. FBI-1 overexpression promoted mobility and invasiveness of JEG-3 and JAR, but not in the presence of the phosphoinositide 3-kinase inhibitor LY294002. These findings suggest that FBI-1 could promote cell migration and invasion via phosphoinositide 3-kinase/Akt signaling. In vivo, nude mice injected with CCA cells with stable FBI-1 knockdown demonstrated reduced tumor growth compared with that in control groups. These findings suggest that FBI-1 is clinically associated with the progression of, and may be a therapeutic target in, GTD, owing to its diverse oncogenic effects on dysregulated trophoblasts. Copyright © 2015 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

The Farley-Buneman Instability in the Solar Chromosphere

NASA Astrophysics Data System (ADS)

Madsen, Chad A.; Dimant, Yakov S.; Oppenheim, Meers M.; Fontenla, Juan M.

2012-10-01

Strong currents drive the Farley-Buneman Instability (FBI) in the E-region ionosphere creating turbulence and heating. The solar chromosphere is a similar weakly ionized region with strong local Pedersen currents, and the FBI may play a role in sustaining the thin layer of enhanced temperature observed there. The plasma of the solar chromosphere requires a new theory of the FBI accounting for the presence of multiple ion species, higher temperatures and collisions between ionized metals and neutral hydrogen. This paper discusses the assumptions underlying the derivation of the multi-species FBI dispersion relation. It presents the predicted critical electron drift velocity needed to trigger the instability. Finally, this work argues that observed chromospheric neutral flow speeds are sufficiently large to trigger the multi-species FBI.

76 FR 27354 - Agency Information Collection Activities; Existing Collection, Comments Requested: Approval of an...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-11

... (DOJ), Federal Bureau of Investigation (FBI), Criminal Justice Information Services (CJIS) Division's... Information Services (CJIS) Division of the Federal Bureau of Investigation (FBI), Department of Justice (DOJ... Investigation (FBI) Criminal Justice Information Services Division's National Instant Criminal Background Check...

Doe v. Attorney General of the United States.

PubMed

1992-12-28

The U.S. District Court, Northern District of California, held that the Federal Bureau of Investigation did not violate the Rehabilitation Act because it did not discriminate against a doctor based solely on his AIDS-related handicap. The doctor had worked at a health care facility, conducting physical examinations of FBI applicants. Upon receiving unsubstantiated information that the doctor had AIDS, the FBI sought additional information. The doctor and the facility assured the FBI that there was no risk to FBI employees, but failed to provide further information about risks and prevention, or to disclose whether the doctor indeed had AIDS. Therefore, the FBI ceased its use of the facility. The court held that a doctor who refuses to allow an inquiry to determine the risk of disease transmission to patients is not "otherwise qualified," so the FBI could not determine whether reasonable accommodations could have been made. The court emphasized that the possibility of physician-to-patient AIDS transmission is remote if appropriate medical procedures are followed.

Farley-Buneman Instability Effects on the Ionosphere and Thermosphere

NASA Astrophysics Data System (ADS)

Liu, J.; Wang, W.; Oppenheim, M. M.; Dimant, Y. S.; Wiltberger, M. J.; Merkin, V. G.

2016-12-01

We have recently implemented a newmodule that includes both the anomalous electron heating and the electron-neutral cooling rate correction associated with the Farley-Buneman Instability (FBI) in the thermosphere-ionosphere electrodynamics global circulation model (TIEGCM). This implementation provides, for the first time, a modeling capability to describe macroscopic effects of the FBI on the ionosphere and thermosphere in the context of a first-principle, self-consistent model. The added heating sources primarily operate between 100 and 130km altitude, and their magnitudes often exceed auroral precipitation heating in the TIEGCM. The induced changes in E region electron temperature in the auroral oval and polar cap by the FBI are remarkable with a maximum Te approaching 2200 K. This is about 4 times larger than the TIEGCM run without FBI heating. Thermosphere wind and composition changes associated with FBI will also be investigated. This investigation demonstrates how researchers can add the important effects of the FBI to magnetosphere-ionosphere-thermosphere models and simulators.

Role of the POZ Zinc Finger Transcription Factor FBI-1 in Human and Murine Adipogenesis

PubMed Central

Laudes, Matthias; Christodoulides, Constantinos; Sewter, Ciaran; Rochford, Justin J.; Considine, Robert V.; Sethi, Jaswinder K.; Vidal-Puig, Antonio; O’Rahilly, Stephen

2015-01-01

Poxvirus zinc finger (POZ) zinc finger domain transcription factors have been shown to play a role in the control of growth arrest and differentiation in several types of mesenchymal cells but not, as yet, adipocytes. We found that a POZ domain protein, factor that binds to inducer of short transcripts-1 (FBI-1), was induced during both murine and human preadipocyte differentiation with maximal expression levels seen at days 2–4. FBI-1 mRNA was expressed in human adipose tissue with the highest levels found in samples from morbidly obese subjects. Murine cell lines constitutively expressing FBI-1 showed evidence for accelerated adipogenesis with earlier induction of markers of differentiation and enhanced lipid accumulation, suggesting that FBI-1 may be an active participant in the differentiation process. Consistent with the properties of this family of proteins in other cell systems, 3T3L1 cells stably overexpressing FBI-1 showed reduced DNA synthesis and reduced expression of cyclin A, cyclin-dependent kinase 2, and p107, proteins known to be involved in the regulation of mitotic clonal expansion. In addition, FBI-1 reduced the transcriptional activity of the cyclin A promoter. Thus, FBI-1, a POZ zinc finger transcription factor, is induced during the early phases of human and murine preadipocyte differentiation where it may contribute to adipogenesis through influencing the switch from cellular proliferation to terminal differentiation. PMID:14701838

99 Facts about the FBI: Questions and Answers.

ERIC Educational Resources Information Center

Federal Bureau of Investigation, Quantico, VA.

This booklet on the Federal Bureau of Investigation (FBI) attempts to provide an overview of the FBI's functions. Presented in a question and answer format, the 99 questions and answers discuss the federal government agency's history, administrative matters, jurisdiction, criminal investigations, security matters, foreign counter-intelligence, and…

28 CFR 17.18 - Prepublication review.

Code of Federal Regulations, 2014 CFR

2014-07-01

... paragraph (j) of this section for FBI personnel, all questions concerning these obligations should be... Security or a designee (or, in the case of FBI employees, the Section Chief, Records/Information... apply with equal force to employees of the FBI with following exceptions and provisos: (1) Nothing in...

28 CFR 17.18 - Prepublication review.

Code of Federal Regulations, 2012 CFR

2012-07-01

... paragraph (j) of this section for FBI personnel, all questions concerning these obligations should be... Security or a designee (or, in the case of FBI employees, the Section Chief, Records/Information... apply with equal force to employees of the FBI with following exceptions and provisos: (1) Nothing in...

The FBI and You.

ERIC Educational Resources Information Center

Conable, Gordon

1990-01-01

Discusses investigation of librarians by the FBI (Federal Bureau of Investigation) and the status of the Library Awareness Program. An American Library Association (ALA) resolution opposing FBI activities in libraries and demanding release of individual files to persons subjected to checks is described. A model letter for individuals to use in…

28 CFR 17.18 - Prepublication review.

Code of Federal Regulations, 2013 CFR

2013-07-01

... paragraph (j) of this section for FBI personnel, all questions concerning these obligations should be... Security or a designee (or, in the case of FBI employees, the Section Chief, Records/Information... apply with equal force to employees of the FBI with following exceptions and provisos: (1) Nothing in...

75 FR 53342 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-31

...), Federal Bureau of Investigation (FBI), proposes to establish a new system of records, the Data Integration and Visualization System, JUSTICE/FBI-021, to support and enhance data search, integration... to develop more efficient methods to analyze FBI data. The Data Integration and Visualization System...

28 CFR 100.21 - Alternative dispute resolution.

Code of Federal Regulations, 2012 CFR

2012-07-01

... impasse arises in negotiations between the FBI and the carrier which precludes the execution of a cooperative agreement, the FBI will consider using mediation with the goal of achieving, in a timely fashion... carrier agree to mediation, the costs of that mediation process shall be shared equally by the FBI and the...

28 CFR 100.17 - Request for payment.

Code of Federal Regulations, 2010 CFR

2010-07-01

... adequate analysis and evaluation of the incurred costs. The FBI reserves the right to request additional... submit to the FBI incurred costs by line item with supporting information. (2) A cost element breakdown... provided to the FBI for the following categories of cost elements, as applicable: (1) Materials. Provide a...

28 CFR 100.21 - Alternative dispute resolution.

Code of Federal Regulations, 2011 CFR

2011-07-01

... impasse arises in negotiations between the FBI and the carrier which precludes the execution of a cooperative agreement, the FBI will consider using mediation with the goal of achieving, in a timely fashion... carrier agree to mediation, the costs of that mediation process shall be shared equally by the FBI and the...

28 CFR 100.19 - Adjustments to agreement estimate.

Code of Federal Regulations, 2012 CFR

2012-07-01

... the FBI when any change affecting the level of reimbursement occurs. (2) Upon such notification, if the adjustment results in an increase in the estimated reimbursement, the FBI will review the... expenditure. (3) The FBI will provide the decision as to the acceptability of any increase to the carrier in...

28 CFR 100.19 - Adjustments to agreement estimate.

Code of Federal Regulations, 2011 CFR

2011-07-01

... the FBI when any change affecting the level of reimbursement occurs. (2) Upon such notification, if the adjustment results in an increase in the estimated reimbursement, the FBI will review the... expenditure. (3) The FBI will provide the decision as to the acceptability of any increase to the carrier in...

Dissent and the State: Unleashing the FBI, 1917-1985.

ERIC Educational Resources Information Center

Theoharis, Athan G.

1990-01-01

Follows development of Federal Bureau of Investigation (FBI). Finds the agency monitored dissident activities and investigated outside its defined jurisdiction with presidential support. States J. Edgar Hoover expanded the FBI's information-gathering procedures beyond legal boundaries resulting in a powerful, autonomous agency that poisoned U.S.…

28 CFR 100.21 - Alternative dispute resolution.

Code of Federal Regulations, 2010 CFR

2010-07-01

... impasse arises in negotiations between the FBI and the carrier which precludes the execution of a cooperative agreement, the FBI will consider using mediation with the goal of achieving, in a timely fashion... carrier agree to mediation, the costs of that mediation process shall be shared equally by the FBI and the...

28 CFR 100.19 - Adjustments to agreement estimate.

Code of Federal Regulations, 2013 CFR

2013-07-01

... the FBI when any change affecting the level of reimbursement occurs. (2) Upon such notification, if the adjustment results in an increase in the estimated reimbursement, the FBI will review the... expenditure. (3) The FBI will provide the decision as to the acceptability of any increase to the carrier in...

28 CFR 100.17 - Request for payment.

Code of Federal Regulations, 2014 CFR

2014-07-01

... adequate analysis and evaluation of the incurred costs. The FBI reserves the right to request additional... submit to the FBI incurred costs by line item with supporting information. (2) A cost element breakdown... provided to the FBI for the following categories of cost elements, as applicable: (1) Materials. Provide a...

28 CFR 100.16 - Cost estimate submission.

Code of Federal Regulations, 2013 CFR

2013-07-01

... evaluation of the estimated costs. The FBI reserves the right to request additional cost data from carriers... if, as determined by the FBI, all cost data reasonably available to the carrier are either submitted... explain the estimating process are required by the FBI and the carrier refuses to provide necessary data...

76 FR 52014 - Agency Information Collection Activities: Applicant Information Form (1-783)

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-19

.... The Department of Justice (DOJ), Federal Bureau of Investigation (FBI), Criminal Justice Information... collection: 1-783 (Applicant Information Form); CJIS Division, FBI, DOJ. (4) Affected public who will be... respondents and the amount of time estimated for an average respondent to respond: Annually, the FBI receives...

28 CFR 8.23 - Redelegation of authority.

Code of Federal Regulations, 2013 CFR

2013-07-01

...) The powers and responsibilities delegated to the FBI Unit Chief, Legal Forfeiture Unit, by the regulations in this part may be redelegated to the attorneys working under the direct supervision of the FBI... permitted. (1) The powers and responsibilities delegated to the DEA Forfeiture Counsel, the FBI Unit Chief...

77 FR 10572 - Agency Information Collection Activities; Existing Collection, Comments Requested: the Voluntary...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-22

... ACTION: 30-Day Notice of Information Collection Under Review. The Department of Justice (DOJ) FBI... Information Services (CJIS) Division of the FBI, Department of Justice (DOJ). (4) Affected Public who will be... the Voluntary Appeal File (VAF) of the FBI Criminal Justice Information Services (CJIS) Division's...

28 CFR 100.16 - Cost estimate submission.

Code of Federal Regulations, 2011 CFR

2011-07-01

... evaluation of the estimated costs. The FBI reserves the right to request additional cost data from carriers... if, as determined by the FBI, all cost data reasonably available to the carrier are either submitted... explain the estimating process are required by the FBI and the carrier refuses to provide necessary data...

28 CFR 8.23 - Redelegation of authority.

Code of Federal Regulations, 2014 CFR

2014-07-01

...) The powers and responsibilities delegated to the FBI Unit Chief, Legal Forfeiture Unit, by the regulations in this part may be redelegated to the attorneys working under the direct supervision of the FBI... permitted. (1) The powers and responsibilities delegated to the DEA Forfeiture Counsel, the FBI Unit Chief...

28 CFR 100.21 - Alternative dispute resolution.

Code of Federal Regulations, 2014 CFR

2014-07-01

... impasse arises in negotiations between the FBI and the carrier which precludes the execution of a cooperative agreement, the FBI will consider using mediation with the goal of achieving, in a timely fashion... carrier agree to mediation, the costs of that mediation process shall be shared equally by the FBI and the...

28 CFR 100.21 - Alternative dispute resolution.

Code of Federal Regulations, 2013 CFR

2013-07-01

... impasse arises in negotiations between the FBI and the carrier which precludes the execution of a cooperative agreement, the FBI will consider using mediation with the goal of achieving, in a timely fashion... carrier agree to mediation, the costs of that mediation process shall be shared equally by the FBI and the...

28 CFR 100.16 - Cost estimate submission.

Code of Federal Regulations, 2012 CFR

2012-07-01

... evaluation of the estimated costs. The FBI reserves the right to request additional cost data from carriers... if, as determined by the FBI, all cost data reasonably available to the carrier are either submitted... explain the estimating process are required by the FBI and the carrier refuses to provide necessary data...

28 CFR 100.17 - Request for payment.

Code of Federal Regulations, 2011 CFR

2011-07-01

... adequate analysis and evaluation of the incurred costs. The FBI reserves the right to request additional... submit to the FBI incurred costs by line item with supporting information. (2) A cost element breakdown... provided to the FBI for the following categories of cost elements, as applicable: (1) Materials. Provide a...

28 CFR 100.17 - Request for payment.

Code of Federal Regulations, 2013 CFR

2013-07-01

... adequate analysis and evaluation of the incurred costs. The FBI reserves the right to request additional... submit to the FBI incurred costs by line item with supporting information. (2) A cost element breakdown... provided to the FBI for the following categories of cost elements, as applicable: (1) Materials. Provide a...

28 CFR 100.16 - Cost estimate submission.

Code of Federal Regulations, 2014 CFR

2014-07-01

... evaluation of the estimated costs. The FBI reserves the right to request additional cost data from carriers... if, as determined by the FBI, all cost data reasonably available to the carrier are either submitted... explain the estimating process are required by the FBI and the carrier refuses to provide necessary data...

28 CFR 100.17 - Request for payment.

Code of Federal Regulations, 2012 CFR

2012-07-01

... adequate analysis and evaluation of the incurred costs. The FBI reserves the right to request additional... submit to the FBI incurred costs by line item with supporting information. (2) A cost element breakdown... provided to the FBI for the following categories of cost elements, as applicable: (1) Materials. Provide a...

28 CFR 100.19 - Adjustments to agreement estimate.

Code of Federal Regulations, 2014 CFR

2014-07-01

... the FBI when any change affecting the level of reimbursement occurs. (2) Upon such notification, if the adjustment results in an increase in the estimated reimbursement, the FBI will review the... expenditure. (3) The FBI will provide the decision as to the acceptability of any increase to the carrier in...

The effect of socio-economic status and food availability on first birth interval in a pre-industrial human population

PubMed Central

Nenko, Ilona; Hayward, Adam D.; Lummaa, Virpi

2014-01-01

Individual variation in nutritional status has direct implications for fitness and thus is crucial in shaping patterns of life-history variation. Nevertheless, it is difficult to measure in natural populations, especially in humans. Here, we used longitudinal data on individual life-histories and annual crop yield variation collected from pre-industrial Finnish populations experiencing natural mortality and fertility to test the validity of first birth interval (FBI; time between marriage and first birth) as a surrogate measure of nutritional status. We evaluated whether women with different socio-economic groups differ in length of FBI, whether women of poorer socio-economic status and experiencing lower crop yields conceive slower following marriage, and whether shorter FBI is associated with higher lifetime breeding success. We found that poorer women had longer FBI and reduced probability of giving birth in months with low food availability, while the FBI of richer women was not affected by variation in food availability. Women with shorter FBI achieved higher lifetime breeding success and a faster reproductive rate. This is, to our knowledge, the first study to show a direct relationship between environmental conditions and speed of childbirth following marriage, highlighting the value of FBI as an indicator of nutritional status when direct data are lacking. PMID:24285194

The effect of socio-economic status and food availability on first birth interval in a pre-industrial human population.

PubMed

Nenko, Ilona; Hayward, Adam D; Lummaa, Virpi

2014-01-22

Individual variation in nutritional status has direct implications for fitness and thus is crucial in shaping patterns of life-history variation. Nevertheless, it is difficult to measure in natural populations, especially in humans. Here, we used longitudinal data on individual life-histories and annual crop yield variation collected from pre-industrial Finnish populations experiencing natural mortality and fertility to test the validity of first birth interval (FBI; time between marriage and first birth) as a surrogate measure of nutritional status. We evaluated whether women with different socio-economic groups differ in length of FBI, whether women of poorer socio-economic status and experiencing lower crop yields conceive slower following marriage, and whether shorter FBI is associated with higher lifetime breeding success. We found that poorer women had longer FBI and reduced probability of giving birth in months with low food availability, while the FBI of richer women was not affected by variation in food availability. Women with shorter FBI achieved higher lifetime breeding success and a faster reproductive rate. This is, to our knowledge, the first study to show a direct relationship between environmental conditions and speed of childbirth following marriage, highlighting the value of FBI as an indicator of nutritional status when direct data are lacking.

High-permittivity thin dielectric padding improves fresh blood imaging of femoral arteries at 3 T.

PubMed

Lindley, Marc D; Kim, Daniel; Morrell, Glen; Heilbrun, Marta E; Storey, Pippa; Hanrahan, Christopher J; Lee, Vivian S

2015-02-01

Fresh blood imaging (FBI) is a useful noncontrast magnetic resonance angiographic (MRA) method for the assessment of peripheral arterial disease, particularly for imaging patients with poor renal function. Compared with 1.5 T, 3 T enables higher signal-to-noise ratio and/or spatiotemporal resolution in FBI. Indeed, previous studies have reported successful FBI of the calf station at 3 T. However, FBI of the thigh station at 3 T has been reported to suffer from signal void in the common femoral artery of 1 thigh only because of the radial symmetry in transmit radiofrequency field (B1+) variation. We sought to increase the signal of femoral artery in FBI at 3 T using high-permittivity dielectric padding. We performed FBI and B1+ mapping of the thigh station at 3 T in 13 human subjects to compare the following 3 dielectric padding settings: no padding, commercially available thick (approximately 5 cm) dielectric padding, and high-permittivity thin (approximately 2 cm) dielectric padding. We characterized the radial symmetry in B1+ variation as well as its impact on the FBI signal at baseline and how dielectric padding improves B1+ and FBI. We evaluated the quality of 3 FBI MRA acquisitions using quantitative (ie, contrast-to-noise ratio of femoral arteries) and qualitative (ie, conspicuity of femoral arteries) analyses. With the subjects positioned on the magnetic resonance table in feet-first, supine orientation, the radial symmetry in B1+ variation attenuates the signal in the right common femoral artery. The signal void can be improved partially with commercial padding and improved further with high-permittivity padding. Averaging the results over the 13 subjects, the mean B1+, contrast-to-noise ratio, and conspicuity scores for the right common femoral artery were significantly higher with high-permittivity padding than with commercial padding and baseline (P < 0.001). Our study shows that high-permittivity dielectric padding can be used to increase the signal of femoral artery in FBI at 3 T.

21 CFR 1316.77 - Administrative forfeiture.

Code of Federal Regulations, 2011 CFR

2011-04-01

... § 1316.75(a), and a claim and bond are not filed within the 20 days hereinbefore mentioned, the FBI Property Management Officer shall declare the property forfeited. The FBI Property Management Officer shall... of the FBI Property Management Officer. (Authority: 28 U.S.C. 509 and 510; 21 U.S.C. 871 and 881(d...

8 CFR 1240.67 - Procedure for interview before an asylum officer.

Code of Federal Regulations, 2013 CFR

2013-01-01

... chapter I, and the Service has received a definitive response from the FBI that a full criminal background... has been completed includes: (1) Confirmation from the FBI that an applicant does not have an administrative or criminal record; (2) Confirmation from the FBI that an applicant has an administrative or a...

8 CFR 240.67 - Procedure for interview before an asylum officer.

Code of Federal Regulations, 2013 CFR

2013-01-01

... definitive response from the FBI that a full criminal background check has been completed. A definitive...) Confirmation from the FBI that an applicant does not have an administrative or criminal record; (2) Confirmation from the FBI that an applicant has an administrative or a criminal record; or (3) Confirmation...

A Quantitative Description of FBI Public Relations.

ERIC Educational Resources Information Center

Gibson, Dirk C.

1997-01-01

States that the Federal Bureau of Investigation (FBI) had the most successful media relations program of all government agencies from the 1930s to the 1980s. Uses quantitative analysis to show why those media efforts were successful. Identifies themes that typified the verbal component of FBI publicity and the broad spectrum of mass communication…

28 CFR 907.4 - Methodology for resolving noncompliance.

Code of Federal Regulations, 2014 CFR

2014-07-01

... recommendations, the Compact Council Chairman shall send a letter to this effect to the FBI or Party State Compact... recommendations to the FBI Director or Designee who, upon approval of the recommendations, shall send a letter to... or local agency, a copy of the Compact Council Chairman's or FBI Director's or Designee's letter...

28 CFR 16.34 - Procedure to obtain change, correction or updating of identification records.

Code of Federal Regulations, 2010 CFR

2010-07-01

... PRODUCTION OR DISCLOSURE OF MATERIAL OR INFORMATION Production of FBI Identification Records in Response to... any entry on his/her record to the FBI, Criminal Justice Information Services (CJIS) Division, ATTN: SCU, Mod. D-2, 1000 Custer Hollow Road, Clarksburg, WV 26306. The FBI will then forward the challenge...

28 CFR 16.34 - Procedure to obtain change, correction or updating of identification records.

Code of Federal Regulations, 2012 CFR

2012-07-01

... PRODUCTION OR DISCLOSURE OF MATERIAL OR INFORMATION Production of FBI Identification Records in Response to... any entry on his/her record to the FBI, Criminal Justice Information Services (CJIS) Division, ATTN: SCU, Mod. D-2, 1000 Custer Hollow Road, Clarksburg, WV 26306. The FBI will then forward the challenge...

21 CFR 1316.77 - Administrative forfeiture.

Code of Federal Regulations, 2010 CFR

2010-04-01

... § 1316.75(a), and a claim and bond are not filed within the 20 days hereinbefore mentioned, the FBI Property Management Officer shall declare the property forfeited. The FBI Property Management Officer shall... of the FBI Property Management Officer. (Authority: 28 U.S.C. 509 and 510; 21 U.S.C. 871 and 881(d...

28 CFR 907.4 - Methodology for resolving noncompliance.

Code of Federal Regulations, 2012 CFR

2012-07-01

... recommendations, the Compact Council Chairman shall send a letter to this effect to the FBI or Party State Compact... recommendations to the FBI Director or Designee who, upon approval of the recommendations, shall send a letter to... or local agency, a copy of the Compact Council Chairman's or FBI Director's or Designee's letter...

28 CFR 907.4 - Methodology for resolving noncompliance.

Code of Federal Regulations, 2011 CFR

2011-07-01

... recommendations, the Compact Council Chairman shall send a letter to this effect to the FBI or Party State Compact... recommendations to the FBI Director or Designee who, upon approval of the recommendations, shall send a letter to... or local agency, a copy of the Compact Council Chairman's or FBI Director's or Designee's letter...

28 CFR 907.4 - Methodology for resolving noncompliance.

Code of Federal Regulations, 2010 CFR

2010-07-01

... recommendations, the Compact Council Chairman shall send a letter to this effect to the FBI or Party State Compact... recommendations to the FBI Director or Designee who, upon approval of the recommendations, shall send a letter to... or local agency, a copy of the Compact Council Chairman's or FBI Director's or Designee's letter...

21 CFR 1316.77 - Administrative forfeiture.

Code of Federal Regulations, 2012 CFR

2012-04-01

... § 1316.75(a), and a claim and bond are not filed within the 20 days hereinbefore mentioned, the FBI Property Management Officer shall declare the property forfeited. The FBI Property Management Officer shall... of the FBI Property Management Officer. (Authority: 28 U.S.C. 509 and 510; 21 U.S.C. 871 and 881(d...

28 CFR 907.4 - Methodology for resolving noncompliance.

Code of Federal Regulations, 2013 CFR

2013-07-01

... recommendations, the Compact Council Chairman shall send a letter to this effect to the FBI or Party State Compact... recommendations to the FBI Director or Designee who, upon approval of the recommendations, shall send a letter to... or local agency, a copy of the Compact Council Chairman's or FBI Director's or Designee's letter...

8 CFR 1240.67 - Procedure for interview before an asylum officer.

Code of Federal Regulations, 2014 CFR

2014-01-01

... chapter I, and the Service has received a definitive response from the FBI that a full criminal background... has been completed includes: (1) Confirmation from the FBI that an applicant does not have an administrative or criminal record; (2) Confirmation from the FBI that an applicant has an administrative or a...

28 CFR 16.34 - Procedure to obtain change, correction or updating of identification records.

Code of Federal Regulations, 2014 CFR

2014-07-01

... PRODUCTION OR DISCLOSURE OF MATERIAL OR INFORMATION Production of FBI Identification Records in Response to... any entry on his/her record to the FBI, Criminal Justice Information Services (CJIS) Division, ATTN: SCU, Mod. D-2, 1000 Custer Hollow Road, Clarksburg, WV 26306. The FBI will then forward the challenge...

28 CFR 16.34 - Procedure to obtain change, correction or updating of identification records.

Code of Federal Regulations, 2011 CFR

2011-07-01

... PRODUCTION OR DISCLOSURE OF MATERIAL OR INFORMATION Production of FBI Identification Records in Response to... any entry on his/her record to the FBI, Criminal Justice Information Services (CJIS) Division, ATTN: SCU, Mod. D-2, 1000 Custer Hollow Road, Clarksburg, WV 26306. The FBI will then forward the challenge...

28 CFR 16.34 - Procedure to obtain change, correction or updating of identification records.

Code of Federal Regulations, 2013 CFR

2013-07-01

... PRODUCTION OR DISCLOSURE OF MATERIAL OR INFORMATION Production of FBI Identification Records in Response to... any entry on his/her record to the FBI, Criminal Justice Information Services (CJIS) Division, ATTN: SCU, Mod. D-2, 1000 Custer Hollow Road, Clarksburg, WV 26306. The FBI will then forward the challenge...

8 CFR 240.67 - Procedure for interview before an asylum officer.

Code of Federal Regulations, 2014 CFR

2014-01-01

... definitive response from the FBI that a full criminal background check has been completed. A definitive...) Confirmation from the FBI that an applicant does not have an administrative or criminal record; (2) Confirmation from the FBI that an applicant has an administrative or a criminal record; or (3) Confirmation...

Protecting the Rights of Whistleblowers

ERIC Educational Resources Information Center

Robinson, Lauren

2005-01-01

Coleen Rowley became one of the most famous whistleblowers in the United States in recent times when she blew the whistle on intelligence blunders at the FBI. The special agent's fiery 13-page letter to FBI Director Robert Mueller in 2002 detailed the FBI's failure to investigate Zacarias Moussaoui, a French national of Moroccan descent known as…

Inhaled foreign bodies: presentation, management and value of history and plain chest radiography in delayed presentation.

PubMed

Sersar, Sameh Ibrahim; Rizk, Walid Hassan; Bilal, Maha; El Diasty, Mohammed M; Eltantawy, Tarik Abudlla; Abdelhakam, Bahaa Badry; Elgamal, Adel Mohamed F; Bieh, Alaa Ali Abou

2006-01-01

To assess the clinical and management aspects of tracheobronchial foreign body (FB) in children and adults; to judge the influence of the operator's experience on the outcome of the procedure and to evaluate the factors associated with delayed diagnosis of FB aspiration (FBA) in children; and to compare clinical, radiologic and bronchoscopic findings in the patients with suspected FB inhalation (FBI). Retrospective review of a 10-year experience (from 1995 to 2005), involving a 1512-bed Mansoura university hospital and a 184-bed Mansoura emergency hospital. Three thousand three hundred patients underwent rigid bronchoscopy for suspected FBI between 1995 and 2005 in Mansoura, Egypt. The data were analyzed in 3 groups: the patients with negative bronchoscopy for FBI (group 1), early (group 2), and delayed diagnosis (group 3). Foreign body was removed using the rigid bronchoscope with or without using the extracting forceps (Egyptian novel technique; Sersar technique). The penetration syndrome and decreased breath sounds were determined in a significantly higher number of the patients with FBI. The plain chest radiography revealed radiopaque foreign bodies (FBs) in 23.56% of all patients with FBI. Pneumonia and atelectasis were more common in the groups with negative bronchoscopy and with delayed diagnosis (P < 0.01). The FBs were mostly of vegetable origin, such as seeds and peanuts. The Egyptian novel (Sersar) technique was used since 2004 April in 100 cases (4.62%) with a history of FBI (pins and or small rounded materials). It was successful in 73 cases of nonimpacted inhaled pins. Bronchoscopy is indicated on appropriate history and on suspicion. To prevent delayed diagnosis, characteristic symptoms, and clinical and radiologic signs of FBI should be checked in all suspected cases. Because clinical and radiologic findings of FBI in delayed cases may mimic other disorders, the clinician must be aware of the likelihood of FBI. C-4.

28 CFR 8.8 - Advertisement and declaration of forfeiture.

Code of Federal Regulations, 2012 CFR

2012-07-01

... forfeiture. 8.8 Section 8.8 Judicial Administration DEPARTMENT OF JUSTICE FBI FORFEITURE AUTHORITY FOR... (FBI) within 20 days from the date of the first publication of the notice a claim to such property and... judicial district in which the property was seized. If a claim is not made within the time period, the FBI...

28 CFR 8.2 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Federal Bureau of Investigation (FBI), it means the Unit Chief, Legal Forfeiture Unit, Office of the General Counsel, FBI, except as used in §§ 8.9(a)(2), 8.9(b)(2), 8.10, and 8.15, where the term... court, U.S. Attorney, seizing agent, local ATF or DEA office, or FBI Headquarters. In addition, a claim...

28 CFR 8.2 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Federal Bureau of Investigation (FBI), it means the Unit Chief, Legal Forfeiture Unit, Office of the General Counsel, FBI, except as used in §§ 8.9(a)(2), 8.9(b)(2), 8.10, and 8.15, where the term... court, U.S. Attorney, seizing agent, local ATF or DEA office, or FBI Headquarters. In addition, a claim...

28 CFR 8.8 - Advertisement and declaration of forfeiture.

Code of Federal Regulations, 2011 CFR

2011-07-01

... forfeiture. 8.8 Section 8.8 Judicial Administration DEPARTMENT OF JUSTICE FBI FORFEITURE AUTHORITY FOR... (FBI) within 20 days from the date of the first publication of the notice a claim to such property and... judicial district in which the property was seized. If a claim is not made within the time period, the FBI...

FBI Director Mueller Cites Partnerships as Key to Combating Crime and Terrorism

ERIC Educational Resources Information Center

Blake, Christopher G.

2008-01-01

At the Public Policy General Session held June 30 during IACLEA's 50th Anniversary Annual Conference, FBI Director Robert S. Mueller told the audience that through its partnerships with IACLEA and other law enforcement organizations and agencies, the FBI has made great strides in combating both crime and terrorism in the communities and on…

49 CFR 1572.405 - Procedures for collection by TSA.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Collection Fee, Threat Assessment Fee, and FBI Fee. (a) Imposition of fees. (1) An individual who applies to... Collection Fee, Threat Assessment Fee, and FBI Fee, in a form and manner approved by TSA, when the individual... accordance with the provisions of 31 U.S.C. 9701 and other applicable Federal law. (3) The FBI Fee required...

49 CFR 1572.405 - Procedures for collection by TSA.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Collection Fee, Threat Assessment Fee, and FBI Fee. (a) Imposition of fees. (1) An individual who applies to... Collection Fee, Threat Assessment Fee, and FBI Fee, in a form and manner approved by TSA, when the individual... accordance with the provisions of 31 U.S.C. 9701 and other applicable Federal law. (3) The FBI Fee required...

Anomalous electron heating effects on the E region ionosphere in TIEGCM

NASA Astrophysics Data System (ADS)

Liu, Jing; Wang, Wenbin; Oppenheim, Meers; Dimant, Yakov; Wiltberger, Michael; Merkin, Slava

2016-03-01

We have recently implemented a new module that includes both the anomalous electron heating and the electron-neutral cooling rate correction associated with the Farley-Buneman Instability (FBI) in the thermosphere-ionosphere electrodynamics global circulation model (TIEGCM). This implementation provides, for the first time, a modeling capability to describe macroscopic effects of the FBI on the ionosphere and thermosphere in the context of a first-principle, self-consistent model. The added heating sources primarily operate between 100 and 130 km altitude, and their magnitudes often exceed auroral precipitation heating in the TIEGCM. The induced changes in E region electron temperature in the auroral oval and polar cap by the FBI are remarkable with a maximum Te approaching 2200 K. This is about 4 times larger than the TIEGCM run without FBI heating. This investigation demonstrates how researchers can add the important effects of the FBI to magnetosphere-ionosphere-thermosphere models and simulators.

Unique Unto Itself: The Records of the Federal Bureau of Investigation, 1908 to 1945

ERIC Educational Resources Information Center

Fox, John F., Jr.

2004-01-01

This paper addresses several misunderstandings about the nature of the FBI's Central Records System. Although depicted in popular culture and much of FBI historiography as a tool for the Cold War suppression of American radicals, the FBI's records system grew out of Department of Justice systems already in place before J. Edgar Hoover became…

28 CFR 25.9 - Retention and destruction of records in the system.

Code of Federal Regulations, 2011 CFR

2011-07-01

... in accordance with established policy. (b) The FBI will maintain an automated NICS Audit Log of all... may be accessed directly only by the FBI and only for the purpose of conducting audits of the use and... license number of the FFL and the proposed date of inspection of the named FFL by ATF, the FBI may extract...

28 CFR 25.10 - Correction of erroneous system information.

Code of Federal Regulations, 2012 CFR

2012-07-01

... conducted the check of the NICS (the “denying agency,” which will be either the FBI or the state or local... application first to the denying agency, i.e., either the FBI or the POC. If the denying agency is unable to... challenge to the accuracy of the record, in writing, to the FBI, NICS Operations Center, Criminal Justice...

28 CFR 25.10 - Correction of erroneous system information.

Code of Federal Regulations, 2014 CFR

2014-07-01

... conducted the check of the NICS (the “denying agency,” which will be either the FBI or the state or local... application first to the denying agency, i.e., either the FBI or the POC. If the denying agency is unable to... challenge to the accuracy of the record, in writing, to the FBI, NICS Operations Center, Criminal Justice...

28 CFR 25.9 - Retention and destruction of records in the system.

Code of Federal Regulations, 2013 CFR

2013-07-01

... in accordance with established policy. (b) The FBI will maintain an automated NICS Audit Log of all... may be accessed directly only by the FBI and only for the purpose of conducting audits of the use and... license number of the FFL and the proposed date of inspection of the named FFL by ATF, the FBI may extract...

28 CFR 25.10 - Correction of erroneous system information.

Code of Federal Regulations, 2011 CFR

2011-07-01

... conducted the check of the NICS (the “denying agency,” which will be either the FBI or the state or local... application first to the denying agency, i.e., either the FBI or the POC. If the denying agency is unable to... challenge to the accuracy of the record, in writing, to the FBI, NICS Operations Center, Criminal Justice...

28 CFR 25.9 - Retention and destruction of records in the system.

Code of Federal Regulations, 2012 CFR

2012-07-01

... in accordance with established policy. (b) The FBI will maintain an automated NICS Audit Log of all... may be accessed directly only by the FBI and only for the purpose of conducting audits of the use and... license number of the FFL and the proposed date of inspection of the named FFL by ATF, the FBI may extract...

28 CFR 25.9 - Retention and destruction of records in the system.

Code of Federal Regulations, 2014 CFR

2014-07-01

... in accordance with established policy. (b) The FBI will maintain an automated NICS Audit Log of all... may be accessed directly only by the FBI and only for the purpose of conducting audits of the use and... license number of the FFL and the proposed date of inspection of the named FFL by ATF, the FBI may extract...

28 CFR 25.10 - Correction of erroneous system information.

Code of Federal Regulations, 2010 CFR

2010-07-01

... conducted the check of the NICS (the “denying agency,” which will be either the FBI or the state or local... application first to the denying agency, i.e., either the FBI or the POC. If the denying agency is unable to... challenge to the accuracy of the record, in writing, to the FBI, NICS Operations Center, Criminal Justice...

28 CFR 25.10 - Correction of erroneous system information.

Code of Federal Regulations, 2013 CFR

2013-07-01

... conducted the check of the NICS (the “denying agency,” which will be either the FBI or the state or local... application first to the denying agency, i.e., either the FBI or the POC. If the denying agency is unable to... challenge to the accuracy of the record, in writing, to the FBI, NICS Operations Center, Criminal Justice...

Foldback intercoil DNA and the mechanism of DNA transposition.

PubMed

Kim, Byung-Dong

2014-09-01

Foldback intercoil (FBI) DNA is formed by the folding back at one point of a non-helical parallel track of double-stranded DNA at as sharp as 180° and the intertwining of two double helixes within each other's major groove to form an intercoil with a diameter of 2.2 nm. FBI DNA has been suggested to mediate intra-molecular homologous recombination of a deletion and inversion. Inter-molecular homologous recombination, known as site-specific insertion, on the other hand, is mediated by the direct perpendicular approach of the FBI DNA tip, as the attP site, onto the target DNA, as the attB site. Transposition of DNA transposons involves the pairing of terminal inverted repeats and 5-7-bp tandem target duplication. FBI DNA configuration effectively explains simple as well as replicative transposition, along with the involvement of an enhancer element. The majority of diverse retrotransposable elements that employ a target site duplication mechanism is also suggested to follow the FBI DNA-mediated perpendicular insertion of the paired intercoil ends by non-homologous end-joining, together with gap filling. A genome-wide perspective of transposable elements in light of FBI DNA is discussed.

Developing and pilot-testing a Finding Balance Intervention for older adult bereaved family caregivers: A randomized feasibility trial.

PubMed

Holtslander, Lorraine; Duggleby, Wendy; Teucher, Ulrich; Cooper, Dan; Bally, Jill M G; Solar, Jessica; Steeves, Megan

2016-04-01

This study aimed to test the feasibility of a psychosocially supportive writing intervention focused on finding balance for older adult bereaved family caregivers of advanced cancer patients. The Finding Balance Intervention (FBI) was tested for feasibility, acceptability and potential influence on increasing hope, coping and balance through a multi-method pilot study employing a randomized trial design with 19 older adults with an average age of 72 years. The intervention group received the FBI and a follow up visit from an RN-RA. The control group received the FBI at a second visit. The FBI, a theory-based intervention was developed from grounded theory qualitative data, applying Delphi methods to design a self-administered, psychosocially supportive, writing intervention for older adults who had lost a spouse after caregiving. Feasibility was assessed and specific modifications identified. The FBI was easy to use, acceptable and of benefit. The FBI offered validation of emotions and ways to discover new ideas to find balance, which may enable bereaved caregivers to move forward on a unique journey through grief. The treatment group showed a statistically significant increase in restoration-oriented coping and higher oscillation activity. The results suggest the FBI was easy to use, acceptable and of benefit. A full scale study, with specific modifications to the design, is needed to test the effectiveness of this innovative intervention. Copyright © 2016 Elsevier Ltd. All rights reserved.

41 CFR 128-1.5009 - Authorization for use of the Federal Bureau of Investigation anti-piracy warning seal.

Code of Federal Regulations, 2013 CFR

2013-07-01

... of these laws and the authority of the FBI to enforce them. (b) The APW Seal is a modified image of the Official FBI Seal with the words “FBI ANTI-PIRACY WARNING” displayed horizontally across its... text or images appear on the same screen or page. (i) “The unauthorized reproduction or distribution of...

41 CFR 128-1.5009 - Authorization for use of the Federal Bureau of Investigation anti-piracy warning seal.

Code of Federal Regulations, 2014 CFR

2014-01-01

... of these laws and the authority of the FBI to enforce them. (b) The APW Seal is a modified image of the Official FBI Seal with the words “FBI ANTI-PIRACY WARNING” displayed horizontally across its... text or images appear on the same screen or page. (i) “The unauthorized reproduction or distribution of...

28 CFR 27.2 - Prohibition against reprisal for making a protected disclosure.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Prohibition against reprisal for making a protected disclosure. (a) Any employee of the FBI, or of any other... fail to take, a personnel action, as defined below, with respect to any FBI employee as a reprisal for...) of 5 U.S.C. 2302(a)(2)(A) taken with respect to an FBI employee other than one in a position which...

28 CFR 27.2 - Prohibition against reprisal for making a protected disclosure.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Prohibition against reprisal for making a protected disclosure. (a) Any employee of the FBI, or of any other... fail to take, a personnel action, as defined below, with respect to any FBI employee as a reprisal for...) of 5 U.S.C. 2302(a)(2)(A) taken with respect to an FBI employee other than one in a position which...

28 CFR 27.2 - Prohibition against reprisal for making a protected disclosure.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Prohibition against reprisal for making a protected disclosure. (a) Any employee of the FBI, or of any other... fail to take, a personnel action, as defined below, with respect to any FBI employee as a reprisal for...) of 5 U.S.C. 2302(a)(2)(A) taken with respect to an FBI employee other than one in a position which...

28 CFR 27.2 - Prohibition against reprisal for making a protected disclosure.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Prohibition against reprisal for making a protected disclosure. (a) Any employee of the FBI, or of any other... fail to take, a personnel action, as defined below, with respect to any FBI employee as a reprisal for...) of 5 U.S.C. 2302(a)(2)(A) taken with respect to an FBI employee other than one in a position which...

28 CFR 27.2 - Prohibition against reprisal for making a protected disclosure.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Prohibition against reprisal for making a protected disclosure. (a) Any employee of the FBI, or of any other... fail to take, a personnel action, as defined below, with respect to any FBI employee as a reprisal for...) of 5 U.S.C. 2302(a)(2)(A) taken with respect to an FBI employee other than one in a position which...

Synchrotron powder X-ray diffraction and structural analysis of Eu0.5La0.5FBiS2-x Se x

NASA Astrophysics Data System (ADS)

Nagasaka, K.; Jinno, G.; Miura, O.; Miura, A.; Moriyoshi, C.; Kuroiwa, Y.; Mizuguchi, Y.

2017-07-01

Eu0.5La0.5FBiS2-x Se x is a new BiS2-based superconductor system. In Eu0.5La0.5FBiS2-x Se x , electron carriers are doped to the BiS2 layer by the substitution of Eu by La. Bulk superconductivity in this system is induced by increasing the in-plane chemical pressure, which is controlled by the Se concentration (x). In this study, we have analysed the crystal structure of Eu0.5La0.5FBiS2-x Se x using synchrotron powder diffraction and the Rietveld refinement. The precise determination of the structural parameters and thermal factors suggest that the emergence of bulk superconductivity in Eu0.5La0.5FBiS2-x Se x is achieved by the enhanced in-plane chemical pressure and the decrease in in-plane disorder.

Occlusal contact of fixed implant prostheses using functional bite impression technique.

PubMed

Suzuki, Yasunori; Shimpo, Hidemasa; Ohkubo, Chikahiro

2015-02-01

Functional bite impression (FBI) has been described as a definitive impression made under occlusal force after functional generated path (FGP) recording. This study compared the accuracy of occlusal contact of implant-fixed prostheses using the FBI technique and the conventional impression technique. Twelve subjects, each missing a single premolar or molar, were selected for this study. The conditions of the occlusal contacts were identified by the modified transillumination method. The occlusal contact condition was determined by comparing the rate of change in the occlusal contact area of the implant-fixed prostheses and both adjacent teeth before and after occlusal adjustment. The rate of change in the occlusal contact area using the FBI technique was 96%, and the rate using the conventional technique was 54%. The occlusal contact of implant prostheses using the FBI technique revealed better accuracy than that of the conventional technique. Regarding the FBI technique, a precise and functional prosthesis could be produced by completing the maxillomandibular registration, impression, and FGP at the same time.

Magnetic resonance angiography with fresh blood imaging for identification of hemangiomas and blood vessels around hemangiomas in oral and maxillofacial regions.

PubMed

Oda, Masafumi; Tanaka, Tatsurou; Kito, Shinji; Matsumoto-Takeda, Shinobu; Otsuka, Kozue; Hayashi, Yuki; Wakasugi-Sato, Nao; Yoshioka, Izumi; Habu, Manabu; Kokuryo, Shinya; Kodama, Masaaki; Nogami, Shinnosuke; Miyamoto, Ikuya; Yamamoto, Noriaki; Ishikawa, Ayataka; Zhang, Min; Matsuo, Kou; Shiiba, Shunji; Seta, Yuji; Yamashita, Yoshihiro; Takahashi, Tetsu; Tominaga, Kazuhiro; Morimoto, Yasuhiro

2012-04-01

To evaluate fresh blood imaging (FBI), a magnetic resonance imaging technique that does not use contrast, for identifying hemangiomas and feeding arteries in the oral and maxillofacial regions. For 16 patients with hemangiomas, FBI visualizations of hemangiomas and feeding arteries in the oral and maxillofacial regions were compared with those from 3-dimensional (3D) phase-contrast magnetic resonance angiography (PC-MRA). Comparisons were based on the conspicuities of blood vessels and the 3D relationships of hemangiomas with the surrounding blood vessels. The conspicuity of hemangiomas, feeding arteries, and blood vessels were significantly better with FBI than with PC-MRA. After differentiating arteries from veins, 3D visualizations of hemangiomas and arteries or veins could be performed with FBI. FBI is a useful method in oral and maxillofacial regions for identifying the relationships between hemangiomas and the surrounding arteries or veins. Crown Copyright © 2012. Published by Mosby, Inc. All rights reserved.

Fabrication of fixed implant prostheses using function bite impression technique (FBI technique).

PubMed

Suzuki, Yasunori; Shimpo, Hidemasa; Ohkubo, Chikahiro; Kurtz, Kenneth S

2012-10-01

The patient was partially edentulous, lacking both the first mandibular molars. The FBI and the conventional impression technique were used for the fabrication of implant-fixed prosthesis replacing the right and left molars, respectively. In the FBI technique, the definitive impression was made under occlusal force and functionally generated path (FGP) recording at the same time. The right and left occlusal contact areas were compared after completing the implant-fixed prosthesis rehabilitation. It has been suggested that accuracy of the impression and maxillomandibular registration is necessary to ensure a satisfactory long-term clinical outcome. The transfer of the exact position of the implants to the working cast is even more important because implants lack the mobility of natural teeth. There are displacement differences between implants and natural teeth under occlusal force. The FBI technique may compensate for this difference in accuracy. Using the FBI technique, a precise prosthesis could be produced by completing simultaneously the maxillomandibular registration, impression and FGP. Copyright © 2012 Japan Prosthodontic Society. All rights reserved.

Transforming Counterterrorism Training in the FBI: Preserving Institutional Memory and Enhancing Knowledge Management

DTIC Science & Technology

2009-03-01

25 B. CONTINUOUS SKILL BUILDING AND STORYTELLING : TWO IMPORTANT FACTORS IN EFFECTIVE KNOWLEDGE MANAGEMENT ...change mandates a shift in the culture and mindset of FBI counterterrorism personnel. “FBI agents and managers have long measured their success on arrests...and enhance knowledge management from the ground up. Currently, new agents are assigned a “training agent ” as a mentor upon reporting to their first

Coexistence of superconductivity and ferromagnetism in Sr0.5Ce0.5FBiS2-xSex (x = 0.5 and 1.0), a non-U material with Tc < TFM

PubMed Central

Thakur, Gohil S.; Fuchs, G.; Nenkov, K.; Haque, Zeba; Gupta, L. C.; Ganguli, A. K.

2016-01-01

We have carried out detailed magnetic and transport studies of the new Sr0.5Ce0.5FBiS2-xSex (0.0 ≤ x ≤ 1.0) superconductors derived by doping Se in Sr0.5Ce0.5FBiS2. Se–doping produces several effects: it suppresses semiconducting–like behavior observed in the undoped Sr0.5Ce0.5FBiS2, the ferromagnetic ordering temperature, TFM, decreases considerably from 7.5 K (in Sr0.5Ce0.5FBiS2) to 3.5 K and the superconducting transition temperature, Tc, gets enhanced slightly to 2.9–3.3 K. Thus in these Se–doped materials, TFM is marginally higher than Tc. Magnetization studies provide evidence of bulk superconductivity in Sr0.5Ce0.5FBiS2-xSex at x ≥ 0.5 in contrast to the undoped Sr0.5Ce0.5FBiS2 (x = 0) where magnetization measurements indicate a small superconducting volume fraction. Quite remarkably, as compared with the effective paramagnetic Ce–moment (~2.2 μB), the ferromagnetically ordered Ce–moment in the superconducting state is rather small (~0.1 μB) suggesting itinerant ferromagnetism. To the best of our knowledge, Sr0.5Ce0.5FBiS2-x Sex (x = 0.5 and 1.0) are distinctive Ce–based bulk superconducting itinerant ferromagnetic materials with Tc < TFM. Furthermore, a novel feature of these materials is that they exhibit a dual and quite unusual hysteresis loop corresponding to both the ferromagnetism and the coexisting bulk superconductivity. PMID:27892482

Deterrence of Nuclear Terrorism via Post-Detonation Attribution: Is the United States on Target?

DTIC Science & Technology

2009-12-01

Dr. Vahid Majidi , then Assistant FBI Director for the Weapons of Mass Destruction Directorate, the FBI Laboratory Division is “central” to...www.fbi.gov/hq/nsb/wmd/wmd_home.htm. 236 Joint Working Group, Nuclear Forensics: Role, State of the Art, and Program Needs, 36. 237 Vahid Majidi ...accessed November 7, 2009). Majidi , Vahid. Written Testimony before the U.S. House of Representatives Homeland Security Committee, Subcommittee on

Utility of behavioral versus cognitive measures in differentiating between subtypes of frontotemporal lobar degeneration and Alzheimer's disease.

PubMed

Heidler-Gary, Jennifer; Gottesman, Rebecca; Newhart, Melissa; Chang, Shannon; Ken, Lynda; Hillis, Argye E

2007-01-01

We hypothesized that a modified version of the Frontal Behavioral Inventory (FBI-mod), along with a few cognitive tests, would be clinically useful in distinguishing between clinically defined Alzheimer's disease (AD) and subtypes of frontotemporal lobar degeneration (FTLD): frontotemporal dementia (dysexecutive type), progressive nonfluent aphasia, and semantic dementia. We studied 80 patients who were diagnosed with AD (n = 30) or FTLD (n = 50), on the basis of a comprehensive neuropsychological battery, imaging, neurological examination, and history. We found significant between-group differences on the FBI-mod, two subtests of the Rey Auditory Verbal Learning Test (verbal learning and delayed recall), and the Trail Making Test Part B (one measure of 'executive functioning'). AD was characterized by relatively severe impairment in verbal learning, delayed recall, and executive functioning, with relatively normal scores on the FBI-mod. Frontotemporal dementia was characterized by relatively severe impairment on the FBI-mod and executive functioning in the absence of severe impairment in verbal learning and recall. Progressive nonfluent aphasia was characterized by severe impairment in executive functioning with relatively normal scores on verbal learning and recall and FBI-mod. Finally, semantic dementia was characterized by relatively severe deficits in delayed recall, but relatively normal performance on new learning, executive functioning, and on FBI-mod. Discriminant function analysis confirmed that the FBI-mod, in conjunction with the Rey Auditory Verbal Learning Test, and the Trail Making Test Part B categorized the majority of patients as subtypes of FTLD or AD in the same way as a full neuropsychological battery, neurological examination, complete history, and imaging. These tests may be useful for efficient clinical diagnosis, although progressive nonfluent aphasia and semantic dementia are likely to be best distinguished by language tests not included in standard neuropsychological test batteries.

MicroRNA-137 represses FBI-1 to inhibit proliferation and in vitro invasion and migration of hepatocellular carcinoma cells.

PubMed

Zhu, Min; Li, Mingyang; Wang, Tao; Linghu, Enqiang; Wu, Benyan

2016-10-01

The pro-oncogene factor that binds to inducer of short transcripts-1 (FBI-1), which is encoded by ZBTB7A gene and belongs to POK (POZ/BTB and KrÜppel) protein family, has been shown to enhance hepatocellular carcinoma (HCC) cells proliferation and multi-drug resistance (MDR) process. However, the possibility that FBI-1 is a therapeutic target for further HCC treatment remains poorly determined. In the current study, two microRNA (miRNA) target prediction programs (TargetScan and MiRanda) were used to identify miR-137 as a potential regulator of FBI-1. Our results showed that expression of miR-137 was downregulated, while FBI-1 was upregulated in clinical HCC specimens, compared with paired non-tumor specimens. Overexpression of miR-137 via adenoviral vector inhibited the proliferation and anchorage-independent growth of HCC cells, HepG2 and MHCC-97H. Our data also showed that miR-137 repressed endogenous expression level of FBI-1, as well as Notch-1 and Survivin. MiR-137 also inhibited in vitro invasion and migration of HCC cells and attenuated their epithelial-mesenchymal transition (EMT) process. Moreover, miR-137 suppressed the growth rate of HepG2 cells in nude mice model. Overexpression of miR-137 via its adenoviral vector enhanced the sensitivity of HepG2 cells to anti-tumor drugs and attenuated the MDR process of a resistance cell line HepG2/adriamycin (ADR). Thus, FBI-1 downregulation mediated by miR-137 overexpression may be a potential strategy for HCC treatment.

A novel manipulation method of human body ownership using an fMRI-compatible master-slave system.

PubMed

Hara, Masayuki; Salomon, Roy; van der Zwaag, Wietske; Kober, Tobias; Rognini, Giulio; Nabae, Hiroyuki; Yamamoto, Akio; Blanke, Olaf; Higuchi, Toshiro

2014-09-30

Bodily self-consciousness has become an important topic in cognitive neuroscience aiming to understand how the brain creates a unified sensation of the self in a body. Specifically, full body illusion (FBI) in which changes in bodily self-consciousness are experimentally introduced by using visual-tactile stimulation has led to improve understanding of these mechanisms. This paper introduces a novel approach to the classic FBI paradigm using a robotic master-slave system which allows us to examine interactions between action and the sense of body ownership in behavioral and MRI experiments. In the proposed approach, the use of the robotic master-slave system enables unique stimulation in which experimental participants can administer tactile cues on their own back using active self-touch. This active self-touch has never been employed in FBI experiments and it allows to test the role of sensorimotor integration and agency (the feeling of control over our actions) in FBI paradigms. The objective of this study is to propose a robotic-haptic platform allowing a new FBI paradigm including the active self-touch in MRI environments. This paper, first, describes the design concept and the performance of the prototype device in the fMRI environment (for 3T and 7T MRI scanners). In addition, the prototype device is applied to a classic FBI experiment, and we verify that the use of the prototype device succeeded in inducing the FBI. These results indicate that the proposed approach has a potential to drive advances in our understanding of human body ownership and agency by allowing novel manipulation and paradigms. Copyright © 2014 Elsevier B.V. All rights reserved.

Fluorescence Behavioral Imaging (FBI) Tracks Identity in Heterogeneous Groups of Drosophila

PubMed Central

Ramdya, Pavan; Schaffter, Thomas; Floreano, Dario; Benton, Richard

2012-01-01

Distinguishing subpopulations in group behavioral experiments can reveal the impact of differences in genetic, pharmacological and life-histories on social interactions and decision-making. Here we describe Fluorescence Behavioral Imaging (FBI), a toolkit that uses transgenic fluorescence to discriminate subpopulations, imaging hardware that simultaneously records behavior and fluorescence expression, and open-source software for automated, high-accuracy determination of genetic identity. Using FBI, we measure courtship partner choice in genetically mixed groups of Drosophila. PMID:23144871

Fluorescence behavioral imaging (FBI) tracks identity in heterogeneous groups of Drosophila.

PubMed

Ramdya, Pavan; Schaffter, Thomas; Floreano, Dario; Benton, Richard

2012-01-01

Distinguishing subpopulations in group behavioral experiments can reveal the impact of differences in genetic, pharmacological and life-histories on social interactions and decision-making. Here we describe Fluorescence Behavioral Imaging (FBI), a toolkit that uses transgenic fluorescence to discriminate subpopulations, imaging hardware that simultaneously records behavior and fluorescence expression, and open-source software for automated, high-accuracy determination of genetic identity. Using FBI, we measure courtship partner choice in genetically mixed groups of Drosophila.

Transforming Leadership in the FBI: A Recommendation for Strategic Change

DTIC Science & Technology

2007-03-01

move to another part of the country (rather than to innovate or to further develop bureau programs). The management system as it existed when I...Supervisory Special Agent Roger Trott who currently serves as the Executive Director of the FBI National Academy Associates. Trott championed the cause of...initiatives occurring in recent times have happened as a result of Trot’s foresight. When asked if the FBI is an organization that is well-led, Trott had

FBI-1, a factor that binds to the HIV-1 inducer of short transcripts (IST), is a POZ domain protein.

PubMed Central

Morrison, D J; Pendergrast, P S; Stavropoulos, P; Colmenares, S U; Kobayashi, R; Hernandez, N

1999-01-01

The HIV-1 promoter directs the synthesis of two classes of transcripts, short, non-polyadenylated transcripts and full-length, polyadenylated transcripts. The synthesis of short transcripts is activated by a bipartite DNA element, the inducer of short transcripts or IST, located downstream of the HIV-1 transcriptional start site, while the synthesis of full-length transcripts is activated by the viral activator Tat. Tat binds to the RNA element TAR, which is encoded largely between the two IST half-elements. Upon activation by Tat, the synthesis of short RNAs is repressed. We have previously purified a factor called FBI-1 (for factor that binds to IST) whose binding to wild-type and mutated ISTs correlated well with the abilities of these ISTs to direct the synthesis of short transcripts. Here, we report the cloning of cDNAs encoding FBI-1. FBI-1 contains a POZ domain at its N-terminus and four Krüppel-type zinc fingers at its C-terminus. The C-terminus is sufficient for specific binding, and FBI-1 can form homomers through its POZ domain and, in vivo, through its zinc finger domain as well. In addition, FBI-1 associates with Tat, suggesting that repression of the short transcripts by Tat may be mediated through interactions between the two factors. PMID:9973611

FBI-1, a factor that binds to the HIV-1 inducer of short transcripts (IST), is a POZ domain protein.

PubMed

Morrison, D J; Pendergrast, P S; Stavropoulos, P; Colmenares, S U; Kobayashi, R; Hernandez, N

1999-03-01

The HIV-1 promoter directs the synthesis of two classes of transcripts, short, non-polyadenylated transcripts and full-length, polyadenylated transcripts. The synthesis of short transcripts is activated by a bipartite DNA element, the inducer of short transcripts or IST, located downstream of the HIV-1 transcriptional start site, while the synthesis of full-length transcripts is activated by the viral activator Tat. Tat binds to the RNA element TAR, which is encoded largely between the two IST half-elements. Upon activation by Tat, the synthesis of short RNAs is repressed. We have previously purified a factor called FBI-1 (for factor that binds to IST) whose binding to wild-type and mutated ISTs correlated well with the abilities of these ISTs to direct the synthesis of short transcripts. Here, we report the cloning of cDNAs encoding FBI-1. FBI-1 contains a POZ domain at its N-terminus and four Krüppel-type zinc fingers at its C-terminus. The C-terminus is sufficient for specific binding, and FBI-1 can form homomers through its POZ domain and, in vivo, through its zinc finger domain as well. In addition, FBI-1 associates with Tat, suggesting that repression of the short transcripts by Tat may be mediated through interactions between the two factors.

Prospective evaluation of behavioral scales in the behavioral variant of frontotemporal dementia.

PubMed

Boutoleau-Bretonnière, Claire; Lebouvier, Thibaud; Volteau, Christelle; Jaulin, Philippe; Lacomblez, Lucette; Damier, Philippe; Thomas-Anterion, Catherine; Vercelletto, Martine

2012-01-01

The Neuropsychiatric Inventory (NPI) and the Frontal Behavioral Inventory (FBI) are widely used in patients with the behavioral variant of frontotemporal dementia (bvFTD). Yet, few data are available on the long-term relevance of these scales. Based on a bvFTD population that participated in the Memantine Clinical Trial (NCT00200538), we studied the evolution and correlation between scores obtained on behavioral scales (NPI and FBI), cognitive scales [Mini-Mental State Examination (MMSE) and Mattis Dementia Rating Scale (MDRS)] and a burden scale [Zarit Burden Inventory (ZBI)]. The assessments were performed at 1 year in 41 patients and at 2 years in 23 patients who agreed to participate in this open-label study. The 2-year scores obtained on the FBI were significantly higher than the scores at inclusion while those obtained on the NPI did not change. There were significant correlations between the FBI, and the MDRS and MMSE, especially regarding the negative items. The ZBI correlated with behavioral scales at all stages for positive items. This study based on a large population shows that the FBI is a better tool than the NPI for the long-term assessment of bvFTD patients. Moreover, the FBI allows a distinction to be made between behavioral disturbances that involve cognitive functions from those which have an important impact on caregiver burden. Copyright © 2012 S. Karger AG, Basel.

Noninvasive identification of peripheral vessels of oral and maxillofacial regions by using electrocardiography-triggered three-dimensional fast asymmetric spin-echo sequences.

PubMed

Tanaka, Tatsurou; Oda, Masafumi; Kito, Shinji; Wakasugi-Sato, Nao; Matsumoto-Takeda, Shinobu; Otsuka, Kozue; Yoshioka, Izumi; Habu, Manabu; Kokuryo, Shinya; Kodama, Masaaki; Nogami, Shinnosuke; Miyamoto, Ikuya; Yamamoto, Noriaki; Ishikawa, Ayataka; Matsuo, Kou; Shiiba, Shunji; Seta, Yuji; Yamashita, Yoshihiro; Takahashi, Tetsu; Tominaga, Kazuhiro; Morimoto, Yasuhiro

2011-10-01

The aim of this study was to evaluate the 3-dimensional images of thinner main peripheral vessels in oral and maxillofacial regions made without contrast medium by using a new technique, fresh blood imaging (FBI). A second objective was to discern arteries from veins by using the combination of FBI with the subtraction technique. Images from FBI were compared with those from 3-dimensional phase-contrast magnetic resonance angiography (MRA) of blood vessels in 20 healthy subjects. All images were scored for visualization and image quality of the main blood vessels. In addition, appropriate flow-spoiled gradient pulses were applied to differentiate arteries from veins in the peripheral vasculature using a combination of FBI sequences and subtraction between systole- and diastole-triggered images. The scores of MRA using FBI for the visualization of thin blood vessels were significantly better than those using phase contrast, whereas scores for the visualization of main blood vessels were equal. Additionally, we succeeded in our initial attempt to differentiate arteries from veins with a reasonable acquisition time. Our initial experience shows that FBI could be a useful method to identify 3-dimensional vasculature and to differentiate arteries from veins among thinner peripheral vessels in the oral and maxillofacial regions without using contrast medium. Copyright © 2011 Mosby, Inc. All rights reserved.

Identification of peripheral vessels in oral and maxillofacial regions on magnetic resonance angiography obtained using a balanced steady-state free-precession sequence with a time-spatial labeling inversion pulse and using fresh blood imaging.

PubMed

Oda, Masafumi; Tanaka, Tatsurou; Yamashita, Yoshihiro; Kito, Shinji; Wakasugi-Sato, Nao; Matsumoto-Takeda, Shinobu; Nishimura, Shun; Habu, Manabu; Kodama, Masaaki; Uehara, Masataka; Kaneuji, Tsuyoshi; Kokuryo, Shinya; Miyamoto, Ikuya; Yoshiga, Daigo; Seta, Yuji; Tominaga, Kazuhiro; Yoshioka, Izumi; Morimoto, Yasuhiro

2013-12-01

To elucidate the characteristics of visualizing thin main peripheral vessels in oral and maxillofacial regions of 3-dimensional magnetic resonance angiography (MRA) using a balanced steady-state free-precession (SSFP) sequence with a time-spatial labeling inversion pulse (time-SLIP) and using fresh blood imaging (FBI). The conspicuity of blood vessels and the characteristics on MRA using SSFP with a time-SLIP was compared with those on MRA using FBI in 20 healthy participants. The conspicuity of the main peripheral arteries was significantly higher on MRA using SSFP with a time-SLIP than on MRA using FBI. MRA scans using SSFP were obtained in all participants, and scans using FBI were obtained in 16 of 20 participants. An electrocardiogram was unnecessary when using SSFP but was necessary when using FBI. MRA obtained using SSFP with a time-SLIP is a useful technique to visualize thin main peripheral arteries in the oral and maxillofacial regions without contrast medium. Copyright © 2013 Elsevier Inc. All rights reserved.

75 FR 66131 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-27

... Integration and Visualization System,'' JUSTICE/FBI-021, which describes the Data Integration and... Liberties Officer. JUSTICE/FBI-021 SYSTEM NAME: Data Integration and Visualization System. * * * * * SYSTEM...

Prospective Investigation of Injury Rates and Injury Risk Factors Among Federal Bureau of Investigation New Agent Trainees, Quantico, Virginia, 2009-2010

DTIC Science & Technology

2010-08-01

assistance of the United States Army Public Health Command (USAPHC) in injury prevention efforts at the FBI New Agent Training Program at the FBI...personnel to apply their experience in injury prevention programs in military training to assist in injury prevention efforts in the FBI New Agent... prevention recommendations USAPHC had made Army-wide. USAPHC personnel proposed a methodology to evaluate injury incidence and injury risk factors

FBI fingerprint identification automation study. AIDS 3 evaluation report. Volume 1: Compendium

NASA Technical Reports Server (NTRS)

Mulhall, B. D. L.

1980-01-01

The primary features of the overall study are encompassed and an evaluation of an automation system is presented. Objectives of the study are described, methods of evaluation are summarized and conclusions about the system's feasibility are presented. Also included is a brief history of fingerprint automation activities within the FBI, the organization of the FBI, a bibliography of documents and records, a data dictionary and a reference set of all of the transparencies presented throughout the study.

28 CFR 16.30 - Purpose and scope.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Production of FBI Identification Records in Response to Written Requests by Subjects Thereof § 16.30 Purpose and scope. This subpart contains the regulations of the Federal Bureau of Investigation (FBI...

28 CFR 16.30 - Purpose and scope.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Production of FBI Identification Records in Response to Written Requests by Subjects Thereof § 16.30 Purpose and scope. This subpart contains the regulations of the Federal Bureau of Investigation (FBI...

28 CFR 16.30 - Purpose and scope.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Production of FBI Identification Records in Response to Written Requests by Subjects Thereof § 16.30 Purpose and scope. This subpart contains the regulations of the Federal Bureau of Investigation (FBI...

28 CFR 16.30 - Purpose and scope.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Production of FBI Identification Records in Response to Written Requests by Subjects Thereof § 16.30 Purpose and scope. This subpart contains the regulations of the Federal Bureau of Investigation (FBI...

28 CFR 16.30 - Purpose and scope.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Production of FBI Identification Records in Response to Written Requests by Subjects Thereof § 16.30 Purpose and scope. This subpart contains the regulations of the Federal Bureau of Investigation (FBI...

77 FR 49830 - Proposed Collection, Comments Requested: FBI National Academy Post-Course Questionnaire for...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-17

..., Research, and Curriculum Development (OTRCD) will be submitting the following information collection... Investigation, Training Division, Curriculum Planning and Support Unit, FBI Academy, Quantico, Virginia 22135 or...

28 CFR 513.12 - Inmate request for record clarification.

Code of Federal Regulations, 2011 CFR

2011-07-01

... MANAGEMENT AND ADMINISTRATION ACCESS TO RECORDS Production or Disclosure of FBI/NCIC Information § 513.12 Inmate request for record clarification. Where the inmate believes that his or her FBI identification...

28 CFR 513.12 - Inmate request for record clarification.

Code of Federal Regulations, 2010 CFR

2010-07-01

... MANAGEMENT AND ADMINISTRATION ACCESS TO RECORDS Production or Disclosure of FBI/NCIC Information § 513.12 Inmate request for record clarification. Where the inmate believes that his or her FBI identification...

28 CFR 513.12 - Inmate request for record clarification.

Code of Federal Regulations, 2013 CFR

2013-07-01

... MANAGEMENT AND ADMINISTRATION ACCESS TO RECORDS Production or Disclosure of FBI/NCIC Information § 513.12 Inmate request for record clarification. Where the inmate believes that his or her FBI identification...

28 CFR 513.12 - Inmate request for record clarification.

Code of Federal Regulations, 2012 CFR

2012-07-01

... MANAGEMENT AND ADMINISTRATION ACCESS TO RECORDS Production or Disclosure of FBI/NCIC Information § 513.12 Inmate request for record clarification. Where the inmate believes that his or her FBI identification...

28 CFR 513.12 - Inmate request for record clarification.

Code of Federal Regulations, 2014 CFR

2014-07-01

... MANAGEMENT AND ADMINISTRATION ACCESS TO RECORDS Production or Disclosure of FBI/NCIC Information § 513.12 Inmate request for record clarification. Where the inmate believes that his or her FBI identification...

28 CFR 50.12 - Exchange of FBI identification records.

Code of Federal Regulations, 2011 CFR

2011-07-01

.... Officials at the governmental institutions and other entities authorized to submit fingerprints and receive... fingerprints will be used to check the criminal history records of the FBI. The officials making the...

28 CFR 50.12 - Exchange of FBI identification records.

Code of Federal Regulations, 2014 CFR

2014-07-01

.... Officials at the governmental institutions and other entities authorized to submit fingerprints and receive... fingerprints will be used to check the criminal history records of the FBI. The officials making the...

28 CFR 50.12 - Exchange of FBI identification records.

Code of Federal Regulations, 2013 CFR

2013-07-01

.... Officials at the governmental institutions and other entities authorized to submit fingerprints and receive... fingerprints will be used to check the criminal history records of the FBI. The officials making the...

28 CFR 50.12 - Exchange of FBI identification records.

Code of Federal Regulations, 2010 CFR

2010-07-01

.... Officials at the governmental institutions and other entities authorized to submit fingerprints and receive... fingerprints will be used to check the criminal history records of the FBI. The officials making the...

28 CFR 50.12 - Exchange of FBI identification records.

Code of Federal Regulations, 2012 CFR

2012-07-01

.... Officials at the governmental institutions and other entities authorized to submit fingerprints and receive... fingerprints will be used to check the criminal history records of the FBI. The officials making the...

Behavioral disturbances differentiate frontotemporal lobar degeneration subtypes and Alzheimer's disease: evidence from the Frontal Behavioral Inventory.

PubMed

Konstantinopoulou, Eleni; Aretouli, Eleni; Ioannidis, Panagiotis; Karacostas, Dimitrios; Kosmidis, Mary H

2013-09-01

Behavioral assessment is useful for the diagnosis of frontotemporal lobar degeneration (FTLD). We explored the ability of the Frontal Behavioral Inventory (FBI) to discriminate between patients with distinct subtypes of FTLD and patients with Alzheimer's disease (AD), as well as the influence of demographic variables on FBI scores. The FBI was administered to the caregivers of 87 patients diagnosed with FTLD [64 behavioral variant FTLD, 19 aphasic variant FTLD (primary progressive aphasia), and 4 motor/extrapyramidal variant (corticobasal syndrome)] and 30 patients with AD. Patients with AD were older than patients with FTLD. The two groups did not differ with respect to duration of illness, level of education, or sex ratio. Age significantly predicted disinhibited positive behaviors, such as perseverations and irritability, whereas education did not contribute to FBI ratings. Classification accuracy for the discrimination of AD and mixed FTLD groups was 81%. Moreover, 88.3% and 83.7% accuracy was achieved for the discrimination of AD and behavioral variant FTLD, and AD and primary progressive aphasia groups, respectively. The Total Negative subscale of the FBI, which summarizes the presence of deficit (negative) behaviors, was the best discriminator. A cut-off score of 17 provided 83% sensitivity and 98% specificity in distinguishing between FTLD and AD patients. The FBI is a sensitive and specific tool for the differential diagnosis of FTLD from AD. The optimal cut-off point for the detection of FTLD patients was lower than that initially proposed. Copyright © 2012 John Wiley & Sons, Ltd.

28 CFR 907.5 - Sanction adjudication.

Code of Federal Regulations, 2011 CFR

2011-07-01

... NONCRIMINAL JUSTICE PURPOSES § 907.5 Sanction adjudication. (a) A Compact Officer of the FBI or a Party State... XI(a) of the Compact. (c) Nothing prohibits the Compact Council from requesting the FBI to exercise...

28 CFR 907.5 - Sanction adjudication.

Code of Federal Regulations, 2014 CFR

2014-07-01

... NONCRIMINAL JUSTICE PURPOSES § 907.5 Sanction adjudication. (a) A Compact Officer of the FBI or a Party State... XI(a) of the Compact. (c) Nothing prohibits the Compact Council from requesting the FBI to exercise...

28 CFR 907.5 - Sanction adjudication.

Code of Federal Regulations, 2010 CFR

2010-07-01

... NONCRIMINAL JUSTICE PURPOSES § 907.5 Sanction adjudication. (a) A Compact Officer of the FBI or a Party State... XI(a) of the Compact. (c) Nothing prohibits the Compact Council from requesting the FBI to exercise...

28 CFR 513.10 - Purpose and scope.

Code of Federal Regulations, 2010 CFR

2010-07-01

... ACCESS TO RECORDS Production or Disclosure of FBI/NCIC Information § 513.10 Purpose and scope. This subpart describes the procedures to be followed by an inmate who requests a copy of his or her FBI...

28 CFR 513.10 - Purpose and scope.

Code of Federal Regulations, 2014 CFR

2014-07-01

... ACCESS TO RECORDS Production or Disclosure of FBI/NCIC Information § 513.10 Purpose and scope. This subpart describes the procedures to be followed by an inmate who requests a copy of his or her FBI...

28 CFR 907.5 - Sanction adjudication.

Code of Federal Regulations, 2012 CFR

2012-07-01

... NONCRIMINAL JUSTICE PURPOSES § 907.5 Sanction adjudication. (a) A Compact Officer of the FBI or a Party State... XI(a) of the Compact. (c) Nothing prohibits the Compact Council from requesting the FBI to exercise...

28 CFR 16.33 - Fee for production of identification record.

Code of Federal Regulations, 2012 CFR

2012-07-01

... MATERIAL OR INFORMATION Production of FBI Identification Records in Response to Written Requests by... directions of the Attorney General of the United States, the Director of the FBI may from time to time...

28 CFR 16.33 - Fee for production of identification record.

Code of Federal Regulations, 2011 CFR

2011-07-01

... MATERIAL OR INFORMATION Production of FBI Identification Records in Response to Written Requests by... directions of the Attorney General of the United States, the Director of the FBI may from time to time...

76 FR 33785 - Notice of Charter Reestablishment

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-09

... upon the FBI by law, I hereby give notice of the reestablishment of the APB Charter. The APB provides... principles of the various criminal justice information systems managed by the FBI's CJIS Division. The APB...

28 CFR 16.33 - Fee for production of identification record.

Code of Federal Regulations, 2014 CFR

2014-07-01

... MATERIAL OR INFORMATION Production of FBI Identification Records in Response to Written Requests by... directions of the Attorney General of the United States, the Director of the FBI may from time to time...

28 CFR 16.33 - Fee for production of identification record.

Code of Federal Regulations, 2013 CFR

2013-07-01

... MATERIAL OR INFORMATION Production of FBI Identification Records in Response to Written Requests by... directions of the Attorney General of the United States, the Director of the FBI may from time to time...

28 CFR 16.33 - Fee for production of identification record.

Code of Federal Regulations, 2010 CFR

2010-07-01

... MATERIAL OR INFORMATION Production of FBI Identification Records in Response to Written Requests by... directions of the Attorney General of the United States, the Director of the FBI may from time to time...

28 CFR 513.10 - Purpose and scope.

Code of Federal Regulations, 2011 CFR

2011-07-01

... ACCESS TO RECORDS Production or Disclosure of FBI/NCIC Information § 513.10 Purpose and scope. This subpart describes the procedures to be followed by an inmate who requests a copy of his or her FBI...

28 CFR 513.10 - Purpose and scope.

Code of Federal Regulations, 2012 CFR

2012-07-01

... ACCESS TO RECORDS Production or Disclosure of FBI/NCIC Information § 513.10 Purpose and scope. This subpart describes the procedures to be followed by an inmate who requests a copy of his or her FBI...

28 CFR 513.10 - Purpose and scope.

Code of Federal Regulations, 2013 CFR

2013-07-01

... ACCESS TO RECORDS Production or Disclosure of FBI/NCIC Information § 513.10 Purpose and scope. This subpart describes the procedures to be followed by an inmate who requests a copy of his or her FBI...

28 CFR 907.5 - Sanction adjudication.

Code of Federal Regulations, 2013 CFR

2013-07-01

... NONCRIMINAL JUSTICE PURPOSES § 907.5 Sanction adjudication. (a) A Compact Officer of the FBI or a Party State... XI(a) of the Compact. (c) Nothing prohibits the Compact Council from requesting the FBI to exercise...

78 FR 29382 - Notice of Charter Reestablishment

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-20

... upon the FBI by law, I hereby give notice of the reestablishment of the APB Charter. The APB provides... principles of the various criminal justice information systems managed by the FBI's CJIS Division. The APB...

49 CFR 1572.405 - Procedures for collection by TSA.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Collection Fee is required for a TSA agent to collect and transmit fingerprints and applicant information, in... renew an HME: $34. (3) The following FBI Fee is required for the FBI to process fingerprint...

49 CFR 1572.405 - Procedures for collection by TSA.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Collection Fee is required for a TSA agent to collect and transmit fingerprints and applicant information, in... renew an HME: $34. (3) The following FBI Fee is required for the FBI to process fingerprint...

49 CFR 1572.405 - Procedures for collection by TSA.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Collection Fee is required for a TSA agent to collect and transmit fingerprints and applicant information, in... renew an HME: $34. (3) The following FBI Fee is required for the FBI to process fingerprint...

Changing epidemiology of food bolus impaction: is eosinophilic esophagitis to blame?

PubMed

Mahesh, Venkat N; Holloway, Richard H; Nguyen, Nam Quoc

2013-06-01

Data on the relationship between epidemiological changes in food bolus impaction (FBI) and its relationship to eosinophilic esophagitis (EoE) are limited. The aim of this study was to evaluate changes in the prevalence and etiology of FBI at the Royal Adelaide Hospital over 15 years. Details of all patients who presented with FBI to Royal Adelaide Hospital (1996-2010) were reviewed from a prospective database. Detailed endoscopic and histological findings were examined for patients admitted under the Gastroenterology team. From 1996-2010, 539 patients were admitted. Prevalence of FBI increased overtime, with a male preponderance. The age at presentation was significantly lower in 2006-2010 (56.2 ± 1.6 years) compared with 2001-2005 (61.6 ± 1.9 years, P=0.03). There was a reduction in the proportion of patients with peptic-related stricture (from 75% [1996-2000] to 41% [2006-2010] [P<0.001]) and an increase in the prevalence of EoE (from 0% [1996-2000] to 35% [2006-2010], P<0.001). The proportion of patients who had esophageal biopsies taken at the index endoscopy also increased (8% [1996-2000] vs 28% [2001-2005] and 61% [2006-2010], P<0.01). There were no significant changes in rate of malignancy or post-surgical strictures. Endoscopic removal of food bolus was required in 86% of cases and, of these, 98% were successful with no complication or death. The prevalence of FBI has increased over the last 15 years. This was associated with an increased prevalence of EoE and a reduction in age of presentation and peptic-related strictures. These findings suggest that EoE is an important cause of FBI and that esophageal mucosal biopsy should be performed in all cases of FBI. © 2013 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.

49 CFR 1572.501 - Fee collection.

Code of Federal Regulations, 2014 CFR

2014-10-01

... fingerprints required under 49 CFR part 1572 to obtain or renew a TWIC, the fee must be remitted to TSA or its... FBI Segment Fee covers the costs for the FBI to process fingerprint identification records, and is the...

49 CFR 1572.501 - Fee collection.

Code of Federal Regulations, 2013 CFR

2013-10-01

... fingerprints required under 49 CFR part 1572 to obtain or renew a TWIC, the fee must be remitted to TSA or its... FBI Segment Fee covers the costs for the FBI to process fingerprint identification records, and is the...

49 CFR 1572.501 - Fee collection.

Code of Federal Regulations, 2012 CFR

2012-10-01

... fingerprints required under 49 CFR part 1572 to obtain or renew a TWIC, the fee must be remitted to TSA or its... Segment covers the cost for the FBI to process fingerprint identification records. The FBI Segment fee is...

49 CFR 1572.501 - Fee collection.

Code of Federal Regulations, 2010 CFR

2010-10-01

... fingerprints required under 49 CFR part 1572 to obtain or renew a TWIC, the fee must be remitted to TSA or its... Segment covers the cost for the FBI to process fingerprint identification records. The FBI Segment fee is...

49 CFR 1572.501 - Fee collection.

Code of Federal Regulations, 2011 CFR

2011-10-01

... fingerprints required under 49 CFR part 1572 to obtain or renew a TWIC, the fee must be remitted to TSA or its... Segment covers the cost for the FBI to process fingerprint identification records. The FBI Segment fee is...

Bacillus subtilis glutamine synthetase regulates its own synthesis by acting as a chaperone to stabilize GlnR-DNA complexes.

PubMed

Fisher, Susan H; Wray, Lewis V

2008-01-22

The Bacillus subtilis GlnR repressor controls gene expression in response to nitrogen availability. Because all GlnR-regulated genes are expressed constitutively in mutants lacking glutamine synthetase (GS), GS is required for repression by GlnR. Feedback-inhibited GS (FBI-GS) was shown to activate GlnR DNA binding with an in vitro electophoretic mobility shift assay (EMSA). The activation of GlnR DNA binding by GS in these experiments depended on the feedback inhibitor glutamine and did not occur with mutant GS proteins defective in regulating GlnR activity in vivo. Although stable GS-GlnR-DNA ternary complexes were not observed in the EMSA experiments, cross-linking experiments showed that a protein-protein interaction occurs between GlnR and FBI-GS. This interaction was reduced in the absence of the feedback inhibitor glutamine and with mutant GS proteins. Because FBI-GS significantly reduced the dissociation rate of the GlnR-DNA complexes, the stability of these complexes is enhanced by FBI-GS. These results argue that FBI-GS acts as a chaperone that activates GlnR DNA binding through a transient protein-protein interaction that stabilizes GlnR-DNA complexes. GS was shown to control the activity of the B. subtilis nitrogen transcription factor TnrA by forming a stable complex between FBI-GS and TnrA that inhibits TnrA DNA binding. Thus, B. subtilis GS is an enzyme with dual catalytic and regulatory functions that uses distinct mechanisms to control the activity of two different transcription factors.

Quantification of ferritin bound iron in human serum using species-specific isotope dilution mass spectrometry.

PubMed

Ren, Yao; Walczyk, Thomas

2014-09-01

Ferritin is a hollow sphere protein composed of 24 subunits that can store up to 4500 iron atoms in its inner cavity. It is mainly found in the liver and spleen but also in serum at trace levels. Serum ferritin is considered as the best single indicator in assessing body iron stores except liver or bone marrow biopsy. However, it is confounded by other disease conditions. Ferritin bound iron (FBI) and ferritin saturation have been suggested as more robust biomarkers. The current techniques for FBI determination are limited by low antibody specificity, low instrument sensitivity and possible analyte losses during sample preparation. The need for a highly sensitive and reliable method is widely recognized. Here we describe a novel technique to detect serum FBI using species-specific isotope dilution mass spectrometry (SS-IDMS). [(57)Fe]-ferritin was produced by biosynthesis and in vitro labeling with the (57)Fe spike in the form of [(57)Fe]-citrate after cell lysis and heat treatment. [(57)Fe]-ferritin for sample spiking was further purified by fast liquid protein chromatography. Serum ferritin and added [(57)Fe]-ferritin were separated from other iron species by ultrafiltration followed by isotopic analysis of FBI using negative thermal ionization mass spectrometry. Repeatability of our assay is 8% with an absolute detection limit of 18 ng FBI in the sample. As compared to other speciation techniques, SS-IDMS offers maximum control over sample losses and species conversion during analysis. The described technique may therefore serve as a reference technique for clinical applications of FBI as a new biomarker for assessing body iron status.

Terrorism and Cybercrime

DTIC Science & Technology

2008-05-01

www.fbi.gov/congress/congress03/farnan051503.htm 63 Federal Bureau of Investigations. “Netting Cyber Criminals : Inside the Connecticut Computer Crimes Task...http://www.fbi.gov/cyberinvest/cyberhome.htm Federal Bureau of Investigations. “Netting Cyber Criminals : Inside the Connecticut Computer Crimes

21 CFR 1316.79 - Petitions for remission or mitigation of forfeiture.

Code of Federal Regulations, 2012 CFR

2012-04-01

... Forfeiture Section or Special Agent-in-Charge of the DEA or FBI, depending upon which agency seized the... addressed to the Director of the FBI or the Administrator of the DEA, depending upon which agency seized the...

21 CFR 1316.79 - Petitions for remission or mitigation of forfeiture.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Forfeiture Section or Special Agent-in-Charge of the DEA or FBI, depending upon which agency seized the... addressed to the Director of the FBI or the Administrator of the DEA, depending upon which agency seized the...

Ending Discrimination Against Arab Americans.

ERIC Educational Resources Information Center

Abourezk, James G.; Revell, Oliver B.

1983-01-01

Abourezk holds that Arab Americans are victims of much racial hatred and stereotyping and that the Federal Bureau of Investigation (FBI) has been the primary governmental agency abusing the civil rights of this group. Revell, an official of the FBI, counters Abourezk's contentions. (GC)

21 CFR 1316.79 - Petitions for remission or mitigation of forfeiture.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Forfeiture Section or Special Agent-in-Charge of the DEA or FBI, depending upon which agency seized the... addressed to the Director of the FBI or the Administrator of the DEA, depending upon which agency seized the...

Purification and characterization of FBI-1, a cellular factor that binds to the human immunodeficiency virus type 1 inducer of short transcripts.

PubMed

Pessler, F; Pendergrast, P S; Hernandez, N

1997-07-01

The human immunodeficiency virus (HIV-1) promoter directs the synthesis of two classes of RNA molecules, short transcripts and full-length transcripts. The synthesis of short transcripts depends on a bipartite DNA element, the inducer of short transcripts (IST), located in large part downstream of the HIV-1 start site of transcription. IST does not require any viral product for function and is thought to direct the assembly of transcription complexes that are incapable of efficient elongation. Nothing is known, however, about the biochemical mechanisms that mediate IST function. Here, we report the identification and purification of a factor that binds specifically to the IST. This factor, FBI-1, recognizes a large bipartite binding site that coincides with the bipartite IST element. It is constituted at least in part by an 86-kDa polypeptide that can be specifically cross-linked to IST. FBI-1 also binds to promoter and attenuation regions of a number of cellular and viral transcription units that are regulated by a transcription elongation block. This observation, together with the observation that the binding of FBI-1 to IST mutants correlates with the ability of these mutants to direct IST function, suggests that FBI-1 may be involved in the establishment of abortive transcription complexes.

Flexible DNA binding of the BTB/POZ-domain protein FBI-1.

PubMed

Pessler, Frank; Hernandez, Nouria

2003-08-01

POZ-domain transcription factors are characterized by the presence of a protein-protein interaction domain called the POZ or BTB domain at their N terminus and zinc fingers at their C terminus. Despite the large number of POZ-domain transcription factors that have been identified to date and the significant insights that have been gained into their cellular functions, relatively little is known about their DNA binding properties. FBI-1 is a BTB/POZ-domain protein that has been shown to modulate HIV-1 Tat trans-activation and to repress transcription of some cellular genes. We have used various viral and cellular FBI-1 binding sites to characterize the interaction of a POZ-domain protein with DNA in detail. We find that FBI-1 binds to inverted sequence repeats downstream of the HIV-1 transcription start site. Remarkably, it binds efficiently to probes carrying these repeats in various orientations and spacings with no particular rotational alignment, indicating that its interaction with DNA is highly flexible. Indeed, FBI-1 binding sites in the adenovirus 2 major late promoter, the c-fos gene, and the c-myc P1 and P2 promoters reveal variously spaced direct, inverted, and everted sequence repeats with the consensus sequence G(A/G)GGG(T/C)(C/T)(T/C)(C/T) for each repeat.

Preliminary evaluation of magnetic resonance fresh blood imaging for diagnosis of Budd-Chiari syndrome.

PubMed

Ren, Ke; Xu, Ke; Sun, Wen-ge; Chen, Yu-shuai; Qi, Xi-xun; Li, Ran-liang; Jin, An-yu

2007-01-20

Budd-Chiari syndrome (BCS) is a rare disease with portal hypertension caused by the blockage of the hepatic vein and/or the inferior vena cava (IVC). Angiography is the "golden standard" for diagnosis, but it is an invasive examination. To assess the diagnostic value of a fresh blood imaging (FBI) relative to BCS, we used a magnetic resonance angiography (MRA) with an FBI sequence for a preoperative evaluation of the BCS patients in this study. Fifty patients who were suspected of having BCS after they had been checked by a B-ultrasound were studied. 2D and 3D FBI were performed on a 1.5T superconductive MR scanner. Original images were rebuilt using a maximal intensity projection (MIP) method on the console. Two doctors reviewed all images before they learned of the angiography results. We then compared the diagnoses obtained from the FBI and angiography results to evaluate the diagnostic value of the FBI. Forty-one patients were diagnosed as BCS and 9 as non-BCS based on an angiography. The FBI correctly diagnosed 38 patients, incorrectly diagnosed 1 patient, and missed diagnosis in 3 patients. Thus, the diagnostic sensitivity of the FBI is 93% (38/41), the specificity is 89% (8/9) and the accuracy is 92% (46/50). The FBI images of the 13 membranous stenoses of the IVC showed a sudden stenosis of the post-liver segment of the IVC. The Images of the 5 patients with a membranous obstruction of the IVC showed IVC thickening and an absence of blood signals in the post-hepatic segment of the IVC. The images of the 4 patients with the segmental thrombosis of the IVC showed abnormal and intermittent signals in the IVC. The images of the 6 patients with a simple hepatic vein obstruction showed obstructive hepatic veins. The images of the 6 patients with the stenosis of both the IVC and the hepatic veins showed the stenosis of the IVC, the thickening of the hepatic veins and the formation of a compensatory circulation within the liver. Lastly, the images of the 7 patients showed a combination of the IVC thrombosis with stenosis or with the obstruction of one or two hepatic veins. An FBI can show a membranous stenosis, and an obstruction and thrombosis of the IVC. In addition, it can also demonstrate the thickening of the flexural hepatic vein and the development of intra-hepatic compensatory branches with slow blood flow. Thus, it can guide the puncturing and opening of the hepatic vein involved in an interventional therapy for BCS patients.

76 FR 11513 - Agency Information Collection Activities; Existing Collection; Comments Requested

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-02

... Justice (DOJ), Federal Bureau of Investigation (FBI), Criminal Justice Information Services (CJIS... Information Services Division, National Instant Criminal Background Check System Section, Module A-3, 1000... Justice Information Services (CJIS) Division of the Federal Bureau of Investigation (FBI), Department of...

Peripersonal space as the space of the bodily self.

PubMed

Noel, Jean-Paul; Pfeiffer, Christian; Blanke, Olaf; Serino, Andrea

2015-11-01

Bodily self-consciousness (BSC) refers to experience of one's self as located within an owned body (self-identification) and as occupying a specific location in space (self-location). BSC can be altered through multisensory stimulation, as in the Full Body Illusion (FBI). If participants view a virtual body from a distance being stroked, while receiving synchronous tactile stroking on their physical body, they feel as if the virtual body were their own and they experience, subjectively, to drift toward the virtual body. Here we hypothesized that--while normally the experience of the body in space depends on the integration of multisensory body-related signals within a limited space surrounding the body (i.e. peripersonal space, PPS)--during the FBI the boundaries of PPS would shift toward the virtual body, that is, toward the position of experienced self-location. To test this hypothesis, we used synchronous visuo-tactile stroking to induce the FBI, as contrasted with a control condition of asynchronous stroking. Concurrently, we applied an audio-tactile interaction paradigm to estimate the boundaries of PPS. PPS was measured in front of and behind the participants' body as the distance where tactile information interacted with auditory stimuli looming in space toward the participant's physical body. We found that during synchronous stroking, i.e. when participants experienced the FBI, PPS boundaries extended in the front-space, toward the avatar, and concurrently shrunk in the back-space, as compared to the asynchronous stroking control condition, when FBI was induced. These findings support the view that during the FBI, PPS boundaries translate toward the virtual body, such that the PPS representation shifts from being centered at the location of the physical body to being now centered at the subjectively experienced location of the self. Copyright © 2015 Elsevier B.V. All rights reserved.

Peripersonal Space as the space of the Bodily Self

PubMed Central

Noel, Jean-Paul; Pfeiffer, Christian; Blanke, Olaf; Serino, Andrea

2016-01-01

Bodily self-consciousness (BSC) refers to experience of our self as located within an owned body (self-identification) and as occupying a specific location in space (self-location). BSC can be altered through multisensory stimulation, as in the Full Body Illusion (FBI). If participants view a virtual body from a distance being stroked, while receiving synchronous tactile stroking on their physical body, they feel such as the virtual body were their own and they experience, subjectively, to drift toward the virtual body. Here we hypothesized that - while normally the experience of the body in space depends on the integration of multisensory body-related signals within a limited space surrounding the body (i.e. peripersonal space, PPS) - during the FBI the boundaries of PPS would shift toward the virtual body, that is toward the position of self-location. To test this hypothesis, we used synchronous visuo-tactile stroking to induce the FBI, as contrasted with a control condition of asynchronous stroking. Concurrently, we applied an audio-tactile interaction paradigm to estimate the boundaries of PPS. PPS was measured in front of and behind the participants' body as the distance where tactile information interacted with auditory stimuli looming in space toward the participant's physical body. We found that during synchronous stroking, i.e. when participants experienced the FBI, PPS boundaries extended in the front-space, toward the avatar, and concurrently shrunk in the back-space, as compared to the asynchronous stroking control condition, where no FBI was induced. These findings support the view that during the FBI, PPS boundaries translate toward the virtual body, such that the PPS representation shifts from being centered at the location of the physical body to being now centered at the subjectively experienced location of the self. PMID:26231086

Development of propidium iodide as a fluorescence probe for the on-line screening of non-specific DNA-intercalators in Fufang Banbianlian Injection.

PubMed

Niu, Yanyan; Li, Sensen; Lin, Zongtao; Liu, Meixian; Wang, Daidong; Wang, Hong; Chen, Shizhong

2016-09-09

Fufang Banbianlian Injection (FBI) has been widely used as an anti-inflammatory and anti-tumor prescription. To understand the relationships between its bioactive ingredients and pharmacological efficacies, our previous study has been successfully identified some DNA-binding compounds in FBI using an established on-line screening system, in which 4',6-diamidino-2-phenylindole (DAPI) was developed as a probe. However, DAPI can be only used to screen ATT-specific DNA minor groove binders, leaving the potential active intercalators unknown in FBI. As a continuation of our studies on FBI, here we present a sensitive analytical method for rapid identification and evaluation of DNA-intercalators using propidium iodide (PI) as a fluorescent probe. We have firstly established the technique of high-performance liquid chromatography-diode-array detector-multistage mass spectrometry-deoxyribonucleic acid-propidium iodide-fluorescence detector (HPLC-DAD-MS(n)-DNA-PI-FLD) system. As a result, 38 of 58 previously identified compounds in FBI were DNA-intercalation active. Interestingly, all previously reported DNA-binders also showed intercalative activities, suggesting they are dual-mode DNA-binders. Quantitative study showed that flavonoid glycosides and chlorogenic acids were the main active compounds in FBI, and displayed similar DNA-binding ability using either DAPI or PI. In addition, 13 active compounds were used to establish the structure-activity relationships. In this study, PI was developed into an on-line method for identifying DNA-intercalators for the first time, and thus it will be a useful high-throughput screening technique for other related samples. Copyright © 2016 Elsevier B.V. All rights reserved.

45 CFR 2540.205 - What procedures must I follow in conducting a National Service Criminal History Check for a...

Code of Federal Regulations, 2013 CFR

2013-10-01

...) Obtain prior, written authorization from the individual for the State registry check, for the FBI... by the applicant; and (g) Ensure that an individual, for whom the results of a required state or FBI...

45 CFR 2540.207 - When may I follow an alternative search procedure or be excepted from a requirement in conducting...

Code of Federal Regulations, 2013 CFR

2013-10-01

... description. (ii) You are not required to conduct the fingerprint-based FBI criminal history check on... prior approval of the Corporation. You are not required to conduct the fingerprint-based FBI criminal...

45 CFR 2540.207 - When may I follow an alternative search procedure or be excepted from a requirement in conducting...

Code of Federal Regulations, 2014 CFR

2014-10-01

... description. (ii) You are not required to conduct the fingerprint-based FBI criminal history check on... prior approval of the Corporation. You are not required to conduct the fingerprint-based FBI criminal...

Bulk Superconductivity Induced by In-Plane Chemical Pressure Effect in Eu0.5La0.5FBiS2-xSex

NASA Astrophysics Data System (ADS)

Jinno, Gen; Jha, Rajveer; Yamada, Akira; Higashinaka, Ryuji; Matsuda, Tatsuma D.; Aoki, Yuji; Nagao, Masanori; Miura, Osuke; Mizuguchi, Yoshikazu

2016-12-01

We have investigated the Se substitution effect on the superconductivity of optimally doped BiS2-based superconductor Eu0.5La0.5FBiS2. Eu0.5La0.5FBiS2-xSex samples with x = 0-1 were synthesized. With increasing x, in-plane chemical pressure is enhanced. For x ≥ 0.6, superconducting transitions with a large shielding volume fraction are observed in magnetic susceptibility measurements, and the highest Tc is 3.8 K for x = 0.8. From low-temperature electrical resistivity measurements, a zero-resistivity state is observed for all the samples, and the highest Tc is observed for x = 0.8. With increasing Se concentration, the characteristic electrical resistivity changes from semiconducting-like to metallic, suggesting that the emergence of bulk superconductivity is linked with the enhanced metallicity. A superconductivity phase diagram of the Eu0.5La0.5FBiS2-xSex superconductor is established.

Performance modeling for large database systems

NASA Astrophysics Data System (ADS)

Schaar, Stephen; Hum, Frank; Romano, Joe

1997-02-01

One of the unique approaches Science Applications International Corporation took to meet performance requirements was to start the modeling effort during the proposal phase of the Interstate Identification Index/Federal Bureau of Investigations (III/FBI) project. The III/FBI Performance Model uses analytical modeling techniques to represent the III/FBI system. Inputs to the model include workloads for each transaction type, record size for each record type, number of records for each file, hardware envelope characteristics, engineering margins and estimates for software instructions, memory, and I/O for each transaction type. The model uses queuing theory to calculate the average transaction queue length. The model calculates a response time and the resources needed for each transaction type. Outputs of the model include the total resources needed for the system, a hardware configuration, and projected inherent and operational availability. The III/FBI Performance Model is used to evaluate what-if scenarios and allows a rapid response to engineering change proposals and technical enhancements.

The backward phase flow and FBI-transform-based Eulerian Gaussian beams for the Schroedinger equation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Leung Shingyu, E-mail: masyleung@ust.h; Qian Jianliang, E-mail: qian@math.msu.ed

2010-11-20

We propose the backward phase flow method to implement the Fourier-Bros-Iagolnitzer (FBI)-transform-based Eulerian Gaussian beam method for solving the Schroedinger equation in the semi-classical regime. The idea of Eulerian Gaussian beams has been first proposed in . In this paper we aim at two crucial computational issues of the Eulerian Gaussian beam method: how to carry out long-time beam propagation and how to compute beam ingredients rapidly in phase space. By virtue of the FBI transform, we address the first issue by introducing the reinitialization strategy into the Eulerian Gaussian beam framework. Essentially we reinitialize beam propagation by applying themore » FBI transform to wavefields at intermediate time steps when the beams become too wide. To address the second issue, inspired by the original phase flow method, we propose the backward phase flow method which allows us to compute beam ingredients rapidly. Numerical examples demonstrate the efficiency and accuracy of the proposed algorithms.« less

The backward phase flow and FBI-transform-based Eulerian Gaussian beams for the Schrödinger equation

NASA Astrophysics Data System (ADS)

Leung, Shingyu; Qian, Jianliang

2010-11-01

We propose the backward phase flow method to implement the Fourier-Bros-Iagolnitzer (FBI)-transform-based Eulerian Gaussian beam method for solving the Schrödinger equation in the semi-classical regime. The idea of Eulerian Gaussian beams has been first proposed in [12]. In this paper we aim at two crucial computational issues of the Eulerian Gaussian beam method: how to carry out long-time beam propagation and how to compute beam ingredients rapidly in phase space. By virtue of the FBI transform, we address the first issue by introducing the reinitialization strategy into the Eulerian Gaussian beam framework. Essentially we reinitialize beam propagation by applying the FBI transform to wavefields at intermediate time steps when the beams become too wide. To address the second issue, inspired by the original phase flow method, we propose the backward phase flow method which allows us to compute beam ingredients rapidly. Numerical examples demonstrate the efficiency and accuracy of the proposed algorithms.

Effect of modulating field on photoreflectance simulated by electroreflectance

NASA Astrophysics Data System (ADS)

Chiou, S. J.; Sung, Y. G.; Wang, D. P.; Huang, K. F.; Huang, T. C.; Chu, A. K.

1999-04-01

Photoreflectance (PR) of surface-intrinsic-n+ (s-i-n+) type doped GaAs has been simulated by electroreflectance (ER). The simulated spectra of the s-i-n+ sample have exhibited many Franz-Keldysh oscillations, which enable the electric field (F) to be determined. It is known that F's determined from PR are subjected to photovoltaic effect and the measured F is close to Fbi-δF/2 when the modulating field, δF≪Fbi, where Fbi is the built-in field of the sample and δF is the modulating field. In this work, we have investigated the relation between the measured F and δF not only for the region where δF≪Fbi holds, but also for a whole range of δF. In order to determine the magnitude of δF, we have used ER to simulate PR, that is, the measurements of ER under a forward bias, which is set to be equal to δF/2.

The FBI wavelet/scalar quantization standard for gray-scale fingerprint image compression

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bradley, J.N.; Brislawn, C.M.; Hopper, T.

1993-05-01

The FBI has recently adopted a standard for the compression of digitized 8-bit gray-scale fingerprint images. The standard is based on scalar quantization of a 64-subband discrete wavelet transform decomposition of the images, followed by Huffman coding. Novel features of the algorithm include the use of symmetric boundary conditions for transforming finite-length signals and a subband decomposition tailored for fingerprint images scanned at 500 dpi. The standard is intended for use in conjunction with ANSI/NBS-CLS 1-1993, American National Standard Data Format for the Interchange of Fingerprint Information, and the FBI`s Integrated Automated Fingerprint Identification System.

The FBI wavelet/scalar quantization standard for gray-scale fingerprint image compression

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bradley, J.N.; Brislawn, C.M.; Hopper, T.

1993-01-01

The FBI has recently adopted a standard for the compression of digitized 8-bit gray-scale fingerprint images. The standard is based on scalar quantization of a 64-subband discrete wavelet transform decomposition of the images, followed by Huffman coding. Novel features of the algorithm include the use of symmetric boundary conditions for transforming finite-length signals and a subband decomposition tailored for fingerprint images scanned at 500 dpi. The standard is intended for use in conjunction with ANSI/NBS-CLS 1-1993, American National Standard Data Format for the Interchange of Fingerprint Information, and the FBI's Integrated Automated Fingerprint Identification System.

77 FR 66636 - Agency Information Collection Activities; Existing Collection, Comments Requested: Approval of an...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-06

... (FBI), Criminal Justice Information Services (CJIS) Division's NICS Section will be submitting the... Program Analyst, Federal Bureau of Investigation, Criminal Justice Information Services Division, National... Information Services (CJIS) Division of the Federal Bureau of Investigation (FBI), Department of Justice (DOJ...

45 CFR 2540.204 - When must I conduct a National Service Criminal History Check on an individual in a covered...

Code of Federal Regulations, 2013 CFR

2013-10-01

... position begins work or starts service. (2) You must initiate state registry or FBI criminal history checks... from state registry or FBI criminal history checks as long as the individual is not permitted access to...

75 FR 53262 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-31

... a new Privacy Act system of records, JUSTICE/FBI- 021, the Data Integration and Visualization System... Act system of records, the Data Integration and Visualization System (DIVS), Justice/FBI-021. The... investigative mission by enabling access, search, integration, and analytics across multiple existing databases...

Purification and characterization of FBI-1, a cellular factor that binds to the human immunodeficiency virus type 1 inducer of short transcripts.

PubMed Central

Pessler, F; Pendergrast, P S; Hernandez, N

1997-01-01

The human immunodeficiency virus (HIV-1) promoter directs the synthesis of two classes of RNA molecules, short transcripts and full-length transcripts. The synthesis of short transcripts depends on a bipartite DNA element, the inducer of short transcripts (IST), located in large part downstream of the HIV-1 start site of transcription. IST does not require any viral product for function and is thought to direct the assembly of transcription complexes that are incapable of efficient elongation. Nothing is known, however, about the biochemical mechanisms that mediate IST function. Here, we report the identification and purification of a factor that binds specifically to the IST. This factor, FBI-1, recognizes a large bipartite binding site that coincides with the bipartite IST element. It is constituted at least in part by an 86-kDa polypeptide that can be specifically cross-linked to IST. FBI-1 also binds to promoter and attenuation regions of a number of cellular and viral transcription units that are regulated by a transcription elongation block. This observation, together with the observation that the binding of FBI-1 to IST mutants correlates with the ability of these mutants to direct IST function, suggests that FBI-1 may be involved in the establishment of abortive transcription complexes. PMID:9199312

75 FR 24970 - FBI Records Management Division National Name Check Program Section User Fees

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-06

... Division National Name Check Program Section User Fees AGENCY: Federal Bureau of Investigation (FBI), Justice. ACTION: Notice. SUMMARY: This notice establishes the user fee schedule for federal agencies... user fees for federal agencies requesting noncriminal name-based background checks of the Central...

Aptitude and Language Learning of FBI Special Agents.

ERIC Educational Resources Information Center

Walker, Marijke; And Others

This study investigated the relationship between aptitude, as measured by Defense Language Aptitude Battery (DLAB) scores, and oral proficiency as measured by the Oral Proficiency Interview (OPI) scores of 72 Federal Bureau of Investigation (FBI) Special Agents who completed basic foreign language training at the Defense Language Institute (DLI).…

The FBI Crime Resistance Program. Technical Assistance Bulletin 24.

ERIC Educational Resources Information Center

National School Resource Network, Washington, DC.

To promote the concept that citizen involvement and responsibility for crime resistance are prime factors in law enforcement, the Federal Bureau of Investigation (FBI) assists local agencies in developing programs to encourage citizen participation. One facet of this program is directed toward educating students about their vulnerability to crime…

75 FR 80313 - Privacy Act of 1974; Implementation

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-22

... Privacy Act listed below for the reasons set forth in the following text. Information in this system of... INFORMATION: Background On August 31, 2010, the FBI published notice of a new Privacy Act system of records... provide more information explaining the FBI's ``internal controls'' in protecting the data itself from...

FBI Police Executive Fellowship Program

ERIC Educational Resources Information Center

Blake, Christopher G.

2012-01-01

In the immediate aftermath of 9/11, FBI Director Robert Mueller, III, established the Office of Law Enforcement Coordination to help ensure more effective information-sharing between the Bureau and state, local and tribal law enforcement agencies. One of the hallmarks of this focused effort to enhance communication is the Police Executive…

78 FR 15046 - InfraGard Membership Application and Profile Proposed Collection, Comments Requested; InfraGard...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-08

... Department of Justice (DOJ), Federal Bureau of Investigation (FBI), Cyber Division's National Industry... Agent, National Industry Partnerships Unit, Federal Bureau of Investigation, Cyber Division, FBIHQ, 935... Industry Partnership Unit (NIPU) Cyber Division of the Federal Bureau of Investigation (FBI), Department of...

78 FR 26654 - Proposed Collection; Comments Requested; Extension of a Currently Approved Collection: InfraGard...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-07

.... The Department of Justice (DOJ), Federal Bureau of Investigation (FBI), Cyber Division's National... Industry Partnerships Unit, Federal Bureau of Investigation, Cyber Division, FBIHQ, 935 Pennsylvania Avenue... Industry Partnership Unit (NIPU) Cyber Division of the Federal Bureau of Investigation (FBI), Department of...

28 CFR 16.31 - Definition of identification record.

Code of Federal Regulations, 2011 CFR

2011-07-01

... “rap sheet,” is a listing of certain information taken from fingerprint submissions retained by the FBI in connection with arrests and, in some instances, includes information taken from fingerprints... record includes the name of the agency or institution that submitted the fingerprints to the FBI. If the...

76 FR 78950 - FBI Criminal Justice Information Services Division; Revised User Fee Schedule

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-20

... fingerprint-based Criminal History Record Information (CHRI) checks for noncriminal justice purposes. DATES... user fees for authorized agencies requesting noncriminal fingerprint-based CHRI checks at 28 CFR 20.31(e). The FBI will periodically review the process of fingerprint- based CHRI checks to determine the...

48 CFR 2452.237-75 - Access to HUD Facilities.

Code of Federal Regulations, 2014 CFR

2014-10-01

...), including an FBI National Criminal History Fingerprint Check, and obtain a PIV Card prior to being permitted..., “Questionnaire for Non-sensitive Positions,” FD 258 (Fingerprint Chart), and a partial Optional Form (OF) 306... employee has successfully cleared the FBI National Criminal History Fingerprint Check and HUD has initiated...

28 CFR 16.31 - Definition of identification record.

Code of Federal Regulations, 2013 CFR

2013-07-01

... “rap sheet,” is a listing of certain information taken from fingerprint submissions retained by the FBI in connection with arrests and, in some instances, includes information taken from fingerprints... record includes the name of the agency or institution that submitted the fingerprints to the FBI. If the...

48 CFR 2452.237-75 - Access to HUD Facilities.

Code of Federal Regulations, 2013 CFR

2013-10-01

...), including an FBI National Criminal History Fingerprint Check, and obtain a PIV Card prior to being permitted..., “Questionnaire for Non-sensitive Positions,” FD 258 (Fingerprint Chart), and a partial Optional Form (OF) 306... employee has successfully cleared the FBI National Criminal History Fingerprint Check and HUD has initiated...

28 CFR 16.31 - Definition of identification record.

Code of Federal Regulations, 2012 CFR

2012-07-01

... “rap sheet,” is a listing of certain information taken from fingerprint submissions retained by the FBI in connection with arrests and, in some instances, includes information taken from fingerprints... record includes the name of the agency or institution that submitted the fingerprints to the FBI. If the...

28 CFR 16.31 - Definition of identification record.

Code of Federal Regulations, 2010 CFR

2010-07-01

... “rap sheet,” is a listing of certain information taken from fingerprint submissions retained by the FBI in connection with arrests and, in some instances, includes information taken from fingerprints... record includes the name of the agency or institution that submitted the fingerprints to the FBI. If the...

28 CFR 16.31 - Definition of identification record.

Code of Federal Regulations, 2014 CFR

2014-07-01

... “rap sheet,” is a listing of certain information taken from fingerprint submissions retained by the FBI in connection with arrests and, in some instances, includes information taken from fingerprints... record includes the name of the agency or institution that submitted the fingerprints to the FBI. If the...

The Federal Bureau of Investigation Needs Better Representation of Women and Minorities.

ERIC Educational Resources Information Center

Comptroller General of the U.S., Washington, DC.

This paper examines the state of employment opportunities for women and minorities in the Federal Bureau of Investigation (FBI). Statistics are presented to illustrate the low representation of women and minorities in professional positions within the FBI and suggestions are made for improving the employment status of these groups. Major areas…

Scenario-Based Training at the F.B.I.

ERIC Educational Resources Information Center

Whitcomb, Chris

1999-01-01

The 16-week training program offered by the FBI Academy for all new agents is a scenario-based curriculum that includes a range of subjects from the rules of evidence to defensive tactics and provides agents with a clear understanding of how to conduct a full investigation from start to finish. (JOW)

Perceptions of Risk Factors for School Violence: Concordance with FBI Risk Profile

ERIC Educational Resources Information Center

Wetterneck, Chad; Sass, Daniel A.; Davies, W. Hobart

2004-01-01

The Federal Bureau of Investigation (FBI, 2000) recently released a report on common background characteristics of school shooters, which also stressed the importance of evaluating the reality of threat. The present study evaluated respondents' ability to discriminate between an unrealistic and a realistic threat and between a low and high risk…

28 CFR 8.7 - Judicial forfeiture.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Judicial forfeiture. 8.7 Section 8.7 Judicial Administration DEPARTMENT OF JUSTICE FBI FORFEITURE AUTHORITY FOR CERTAIN STATUTES § 8.7 Judicial... 5312(a)(3) of title 31 of the United States Code, the Special Agent in Charge of the FBI field office...

28 CFR 8.7 - Judicial forfeiture.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Judicial forfeiture. 8.7 Section 8.7 Judicial Administration DEPARTMENT OF JUSTICE FBI FORFEITURE AUTHORITY FOR CERTAIN STATUTES § 8.7 Judicial... 5312(a)(3) of title 31 of the United States Code, the Special Agent in Charge of the FBI field office...

Perceptions of Risk Factors for School Violence: Concordance with FBI Risk Profile

ERIC Educational Resources Information Center

Wetterneck, Chad; Sass, Daniel A.; Davies, W. Hobart

2005-01-01

The Federal Bureau of Investigation (FBI, 2000) recently released a report on common background characteristics of school shooters, which also stressed the importance of evaluating the reality of threat. The present study evaluated respondents' ability to discriminate between an unrealistic and a realistic threat and between a low and high risk…

28 CFR 8.7 - Judicial forfeiture.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Judicial forfeiture. 8.7 Section 8.7 Judicial Administration DEPARTMENT OF JUSTICE FBI FORFEITURE AUTHORITY FOR CERTAIN STATUTES § 8.7 Judicial... 5312(a)(3) of title 31 of the United States Code, the Special Agent in Charge of the FBI field office...

28 CFR 0.29d - Whistleblower protection for FBI employees.

Code of Federal Regulations, 2010 CFR

2010-07-01

... employees. 0.29d Section 0.29d Judicial Administration DEPARTMENT OF JUSTICE ORGANIZATION OF THE DEPARTMENT OF JUSTICE 4-Office of the Inspector General § 0.29d Whistleblower protection for FBI employees. (a... funds, an abuse of authority, or a substantial and specific danger to public health or safety are...

76 FR 65535 - Privacy Act of 1974; System of Records

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-21

...) and 72 FR 3410 (Jan. 25, 2007)). TURK is the method by which the FBI tracks the workload of its... supervision of the FBI who are required to keep track of workload in TURK, including: Special Agents... function related to these records. Paper records are stored in locked GSA-approved storage containers...

48 CFR 1352.237-71 - Security processing requirements-low risk contracts.

Code of Federal Regulations, 2012 CFR

2012-10-01

... processed. The Sponsor will forward a completed Form OFI-86C, FD-258, Fingerprint Chart, and Credit Release... (DCII), FBI Fingerprint (FBIF), and the FBI Information Management Division (FBIN). (5) In addition, for.... Fingerprints and a Credit Release Authorization must be completed within three working days from start of work...

32 CFR 154.35 - Personal data provided by the subject of the investigation.

Code of Federal Regulations, 2012 CFR

2012-07-01

... appropriate investigative forms, provide fingerprints of a quality acceptable to the FBI, and execute a signed... a fingerprint card indicating that the quality of the fingerprints is not acceptable, an additional set of fingerprints will be obtained from the subject. In the event the FBI indicates that the...

48 CFR 1352.237-71 - Security processing requirements-low risk contracts.

Code of Federal Regulations, 2014 CFR

2014-10-01

... processed. The Sponsor will forward a completed Form OFI-86C, FD-258, Fingerprint Chart, and Credit Release... (DCII), FBI Fingerprint (FBIF), and the FBI Information Management Division (FBIN). (5) In addition, for.... Fingerprints and a Credit Release Authorization must be completed within three working days from start of work...

48 CFR 1352.237-71 - Security processing requirements-low risk contracts.

Code of Federal Regulations, 2011 CFR

2011-10-01

... processed. The Sponsor will forward a completed Form OFI-86C, FD-258, Fingerprint Chart, and Credit Release... (DCII), FBI Fingerprint (FBIF), and the FBI Information Management Division (FBIN). (5) In addition, for.... Fingerprints and a Credit Release Authorization must be completed within three working days from start of work...

48 CFR 1352.237-71 - Security processing requirements-low risk contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... processed. The Sponsor will forward a completed Form OFI-86C, FD-258, Fingerprint Chart, and Credit Release... (DCII), FBI Fingerprint (FBIF), and the FBI Information Management Division (FBIN). (5) In addition, for.... Fingerprints and a Credit Release Authorization must be completed within three working days from start of work...

48 CFR 1352.237-71 - Security processing requirements-low risk contracts.

Code of Federal Regulations, 2013 CFR

2013-10-01

... processed. The Sponsor will forward a completed Form OFI-86C, FD-258, Fingerprint Chart, and Credit Release... (DCII), FBI Fingerprint (FBIF), and the FBI Information Management Division (FBIN). (5) In addition, for.... Fingerprints and a Credit Release Authorization must be completed within three working days from start of work...

32 CFR 154.35 - Personal data provided by the subject of the investigation.

Code of Federal Regulations, 2014 CFR

2014-07-01

... appropriate investigative forms, provide fingerprints of a quality acceptable to the FBI, and execute a signed... a fingerprint card indicating that the quality of the fingerprints is not acceptable, an additional set of fingerprints will be obtained from the subject. In the event the FBI indicates that the...

32 CFR 154.35 - Personal data provided by the subject of the investigation.

Code of Federal Regulations, 2013 CFR

2013-07-01

... appropriate investigative forms, provide fingerprints of a quality acceptable to the FBI, and execute a signed... a fingerprint card indicating that the quality of the fingerprints is not acceptable, an additional set of fingerprints will be obtained from the subject. In the event the FBI indicates that the...

32 CFR 154.35 - Personal data provided by the subject of the investigation.

Code of Federal Regulations, 2011 CFR

2011-07-01

... appropriate investigative forms, provide fingerprints of a quality acceptable to the FBI, and execute a signed... a fingerprint card indicating that the quality of the fingerprints is not acceptable, an additional set of fingerprints will be obtained from the subject. In the event the FBI indicates that the...

32 CFR 154.35 - Personal data provided by the subject of the investigation.

Code of Federal Regulations, 2010 CFR

2010-07-01

... appropriate investigative forms, provide fingerprints of a quality acceptable to the FBI, and execute a signed... a fingerprint card indicating that the quality of the fingerprints is not acceptable, an additional set of fingerprints will be obtained from the subject. In the event the FBI indicates that the...

FBI Fingerprint Image Capture System High-Speed-Front-End throughput modeling

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rathke, P.M.

1993-09-01

The Federal Bureau of Investigation (FBI) has undertaken a major modernization effort called the Integrated Automated Fingerprint Identification System (IAFISS). This system will provide centralized identification services using automated fingerprint, subject descriptor, mugshot, and document processing. A high-speed Fingerprint Image Capture System (FICS) is under development as part of the IAFIS program. The FICS will capture digital and microfilm images of FBI fingerprint cards for input into a central database. One FICS design supports two front-end scanning subsystems, known as the High-Speed-Front-End (HSFE) and Low-Speed-Front-End, to supply image data to a common data processing subsystem. The production rate of themore » HSFE is critical to meeting the FBI`s fingerprint card processing schedule. A model of the HSFE has been developed to help identify the issues driving the production rate, assist in the development of component specifications, and guide the evolution of an operations plan. A description of the model development is given, the assumptions are presented, and some HSFE throughput analysis is performed.« less

Optimum Damping in a Non-Linear Base Isolation System

NASA Astrophysics Data System (ADS)

Jangid, R. S.

1996-02-01

Optimum isolation damping for minimum acceleration of a base-isolated structure subjected to earthquake ground excitation is investigated. The stochastic model of the El-Centro1940 earthquake, which preserves the non-stationary evolution of amplitude and frequency content of ground motion, is used as an earthquake excitation. The base isolated structure consists of a linear flexible shear type multi-storey building supported on a base isolation system. The resilient-friction base isolator (R-FBI) is considered as an isolation system. The non-stationary stochastic response of the system is obtained by the time dependent equivalent linearization technique as the force-deformation of the R-FBI system is non-linear. The optimum damping of the R-FBI system is obtained under important parametric variations; i.e., the coefficient of friction of the R-FBI system, the period and damping of the superstructure; the effective period of base isolation. The criterion selected for optimality is the minimization of the top floor root mean square (r.m.s.) acceleration. It is shown that the above parameters have significant effects on optimum isolation damping.

A Virtual Reality Full Body Illusion Improves Body Image Disturbance in Anorexia Nervosa.

PubMed

Keizer, Anouk; van Elburg, Annemarie; Helms, Rossa; Dijkerman, H Chris

2016-01-01

Patients with anorexia nervosa (AN) have a persistent distorted experience of the size of their body. Previously we found that the Rubber Hand Illusion improves hand size estimation in this group. Here we investigated whether a Full Body Illusion (FBI) affects body size estimation of body parts more emotionally salient than the hand. In the FBI, analogue to the RHI, participants experience ownership over an entire virtual body in VR after synchronous visuo-tactile stimulation of the actual and virtual body. We asked participants to estimate their body size (shoulders, abdomen, hips) before the FBI was induced, directly after induction and at ~2 hour 45 minutes follow-up. The results showed that AN patients (N = 30) decrease the overestimation of their shoulders, abdomen and hips directly after the FBI was induced. This effect was strongest for estimates of circumference, and also observed in the asynchronous control condition of the illusion. Moreover, at follow-up, the improvements in body size estimation could still be observed in the AN group. Notably, the HC group (N = 29) also showed changes in body size estimation after the FBI, but the effect showed a different pattern than that of the AN group. The results lead us to conclude that the disturbed experience of body size in AN is flexible and can be changed, even for highly emotional body parts. As such this study offers novel starting points from which new interventions for body image disturbance in AN can be developed.

Rapid identification of anonymous subjects in large criminal databases: problems and solutions in IAFIS III/FBI subject searches

NASA Astrophysics Data System (ADS)

Kutzleb, C. D.

1997-02-01

The high incidence of recidivism (repeat offenders) in the criminal population makes the use of the IAFIS III/FBI criminal database an important tool in law enforcement. The problems and solutions employed by IAFIS III/FBI criminal subject searches are discussed for the following topics: (1) subject search selectivity and reliability; (2) the difficulty and limitations of identifying subjects whose anonymity may be a prime objective; (3) database size, search workload, and search response time; (4) techniques and advantages of normalizing the variability in an individual's name and identifying features into identifiable and discrete categories; and (5) the use of database demographics to estimate the likelihood of a match between a search subject and database subjects.

The FBI compression standard for digitized fingerprint images

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brislawn, C.M.; Bradley, J.N.; Onyshczak, R.J.

1996-10-01

The FBI has formulated national standards for digitization and compression of gray-scale fingerprint images. The compression algorithm for the digitized images is based on adaptive uniform scalar quantization of a discrete wavelet transform subband decomposition, a technique referred to as the wavelet/scalar quantization method. The algorithm produces archival-quality images at compression ratios of around 15 to 1 and will allow the current database of paper fingerprint cards to be replaced by digital imagery. A compliance testing program is also being implemented to ensure high standards of image quality and interchangeability of data between different implementations. We will review the currentmore » status of the FBI standard, including the compliance testing process and the details of the first-generation encoder.« less

FBI compression standard for digitized fingerprint images

NASA Astrophysics Data System (ADS)

Brislawn, Christopher M.; Bradley, Jonathan N.; Onyshczak, Remigius J.; Hopper, Thomas

1996-11-01

The FBI has formulated national standards for digitization and compression of gray-scale fingerprint images. The compression algorithm for the digitized images is based on adaptive uniform scalar quantization of a discrete wavelet transform subband decomposition, a technique referred to as the wavelet/scalar quantization method. The algorithm produces archival-quality images at compression ratios of around 15 to 1 and will allow the current database of paper fingerprint cards to be replaced by digital imagery. A compliance testing program is also being implemented to ensure high standards of image quality and interchangeability of data between different implementations. We will review the current status of the FBI standard, including the compliance testing process and the details of the first-generation encoder.

Calculation of the fractional interstitial component of boron diffusion and segregation coefficient of boron in Si0.8Ge0.2

NASA Astrophysics Data System (ADS)

Fang, Tilden T.; Fang, Wingra T. C.; Griffin, Peter B.; Plummer, James D.

1996-02-01

Investigation of boron diffusion in strained silicon germanium buried layers reveals a fractional interstitial component of boron diffusion (fBI) in Se0.8Ge0.2 approximately equal to the fBI value in silicon. In conjunction with computer-simulated boron profiles, the results yield an absolute lower-bound of fBI in Si0.8Ge0.2 of ˜0.8. In addition, the experimental methodology provides a unique vehicle for measuring the segregation coefficient; oxidation-enhanced diffusion is used instead of an extended, inert anneal to rapidly diffuse the dopant to equilibrium levels across the interface, allowing the segregation coefficient to be measured more quickly.

Elongation of the Poly-γ-glutamate Tail of F420 Requires Both Domains of the F420:γ-Glutamyl Ligase (FbiB) of Mycobacterium tuberculosis*

PubMed Central

Bashiri, Ghader; Rehan, Aisyah M.; Sreebhavan, Sreevalsan; Baker, Heather M.; Baker, Edward N.; Squire, Christopher J.

2016-01-01

Cofactor F420 is an electron carrier with a major role in the oxidoreductive reactions of Mycobacterium tuberculosis, the causative agent of tuberculosis. A γ-glutamyl ligase catalyzes the final steps of the F420 biosynthesis pathway by successive additions of l-glutamate residues to F420-0, producing a poly-γ-glutamate tail. The enzyme responsible for this reaction in archaea (CofE) comprises a single domain and produces F420-2 as the major species. The homologous M. tuberculosis enzyme, FbiB, is a two-domain protein and produces F420 with predominantly 5–7 l-glutamate residues in the poly-γ-glutamate tail. The N-terminal domain of FbiB is homologous to CofE with an annotated γ-glutamyl ligase activity, whereas the C-terminal domain has sequence similarity to an FMN-dependent family of nitroreductase enzymes. Here we demonstrate that full-length FbiB adds multiple l-glutamate residues to F420-0 in vitro to produce F420-5 after 24 h; communication between the two domains is critical for full γ-glutamyl ligase activity. We also present crystal structures of the C-terminal domain of FbiB in apo-, F420-0-, and FMN-bound states, displaying distinct sites for F420-0 and FMN ligands that partially overlap. Finally, we discuss the features of a full-length structural model produced by small angle x-ray scattering and its implications for the role of N- and C-terminal domains in catalysis. PMID:26861878

Disease progression in C9orf72 mutation carriers.

PubMed

Floeter, Mary K; Traynor, Bryan J; Farren, Jennifer; Braun, Laura E; Tierney, Michael; Wiggs, Edythe A; Wu, Tianxia

2017-07-18

To assess changes in 3 clinical measures, the Revised ALS Functional Rating Scale (ALSFRS-R), letter fluency, and Frontal Behavioral Inventory (FBI), over time in C9orf72 mutation carriers (C9+) with varied clinical phenotypes. Thirty-four unrelated participants with mutations in C9orf72 were enrolled in a prospective natural history study. Participants were classified as asymptomatic, amyotrophic lateral sclerosis (ALS), ALS-familial frontotemporal dementia (FTD), or behavioral-variant FTD by clinical diagnostic criteria. Diagnostic cognitive and motor tests were repeated at 6 and 18 months. The ALSFRS-R, letter fluency, and FBI were administered at baseline and follow-up visits at 6, 12, and 18 months. The clinical diagnosis of most patients did not change over the follow-up. ALSFRS-R scores correlated with measures of motor function. Letter fluency correlated with FBI and cognitive tests. ALSFRS-R, letter fluency, and FBI differed among the C9+ diagnostic subgroups at enrollment and worsened over follow-up in symptomatic patients, with different slopes among the subgroups. Most patients survived to the 6-month time point after enrollment. Survival of C9+ patients with ALS and C9+ patients with ALS-FTD declined over the 12- and 18-month follow-up. The pattern of scores of the ALSFRS-R, letter fluency, and FBI distinguished between ALS, ALS-FTD, and FTD presentations of C9orf72 mutation carriers and asymptomatic carriers. Longitudinal changes in these measures occurred with disease progression in a manner consistent with presenting phenotype. © 2017 American Academy of Neurology.

A Virtual Reality Full Body Illusion Improves Body Image Disturbance in Anorexia Nervosa

PubMed Central

Keizer, Anouk; van Elburg, Annemarie; Helms, Rossa; Dijkerman, H. Chris

2016-01-01

Background Patients with anorexia nervosa (AN) have a persistent distorted experience of the size of their body. Previously we found that the Rubber Hand Illusion improves hand size estimation in this group. Here we investigated whether a Full Body Illusion (FBI) affects body size estimation of body parts more emotionally salient than the hand. In the FBI, analogue to the RHI, participants experience ownership over an entire virtual body in VR after synchronous visuo-tactile stimulation of the actual and virtual body. Methods and Results We asked participants to estimate their body size (shoulders, abdomen, hips) before the FBI was induced, directly after induction and at ~2 hour 45 minutes follow-up. The results showed that AN patients (N = 30) decrease the overestimation of their shoulders, abdomen and hips directly after the FBI was induced. This effect was strongest for estimates of circumference, and also observed in the asynchronous control condition of the illusion. Moreover, at follow-up, the improvements in body size estimation could still be observed in the AN group. Notably, the HC group (N = 29) also showed changes in body size estimation after the FBI, but the effect showed a different pattern than that of the AN group. Conclusion The results lead us to conclude that the disturbed experience of body size in AN is flexible and can be changed, even for highly emotional body parts. As such this study offers novel starting points from which new interventions for body image disturbance in AN can be developed. PMID:27711234

Safe Schools: What the Southeast Is Doing.

ERIC Educational Resources Information Center

SERVE Policy Brief, 1996

1996-01-01

Virtually no school is safe from violence. FBI statistics, which show that juvenile crimes actually peaked during the mid-1970s, are at odds with the public perception that crime rates among young people are at an all-time high. The FBI acknowledges, however, that the crimes committed by young people tend to be more serious than in the past, and…

The FBI's Library Awareness Program: National Security vs Government Intrusion into American Libraries [and] The KGB and the Library Target.

ERIC Educational Resources Information Center

Information Reports and Bibliographies, 1988

1988-01-01

Presents statements made to the House Judiciary Subcommittee on Civil and Constitutional Rights by representatives of the Federal Bureau of Investigation and the library community concerning the surveillance of library users' reading habits as a national security measure. An FBI study on the extent of Soviet intelligence service's utilization of…

78 FR 35984 - Interim Eligible Class of NRC-Licensed Facilities; Docket Nos. (as Shown in Attachment 1...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-14

... consisting of a fingerprint-based background check against applicable Federal Bureau of Investigation (FBI... completed hard-copy FBI Form FD- 258, ``Fingerprint Card,'' to the NRC as specified in Attachment 3, for all... Section 161A.b. shall be subject to a background check by the Attorney General, based on fingerprints and...

First Simulations of a Collisional Two-Stream Instability in the Chromosphere

NASA Astrophysics Data System (ADS)

Oppenheim, Meers; Dimant, Yakov; Madsen, Chad Allen; Fontenla, Juan

2014-06-01

Observations and modeling shows that immediately above the temperature minimum in the solar atmosphere, a steep rise from below 4,000 K to over 6,000K occurs. Recent papers show that a collisional two-stream plasma instability called the Farley-Buneman Instability can develop at the altitudes where this increase occurs. This instability may play an important role in transferring energy from turbulent neutral flows originating in the photosphere to the mid-chromosphere in the form of heat. Plasma turbulence resulting from this instability could account for some or most of this intense chromospheric heating. This paper presents a set of simulations showing the development and evolution of the Farley-Buneman Instability (FBI) applicable to the chromosphere. It compares these results with the better-understood ionospheric FBI. It examines the linear behavior and the dependence of growth rates for a range of altitudes and driving flows. It also presents the first study of FBI driven plasma nonlinearities and turbulence in the chromosphere. This research should help us evaluate the FBI as a mechanism to convert neutral flow and turbulence energy into electron thermal energy in the quiet Sun.

The transcription factor FBI-1/OCZF/LRF is expressed in osteoclasts and regulates RANKL-induced osteoclast formation in vitro and in vivo.

PubMed

Kukita, Akiko; Kukita, Toshio; Nagata, Kengo; Teramachi, Junpei; Li, Yin-Ji; Yoshida, Hiroki; Miyamoto, Hiroshi; Gay, Steffen; Pessler, Frank; Shobuike, Takeo

2011-09-01

Since transcription factors expressed in osteoclasts are possible targets for regulation of bone destruction in bone disorders, we investigated the expression of the transcription factor FBI-1/OCZF/LRF (in humans, factor that binds to inducer of short transcripts of human immunodeficiency virus type 1; in rats, osteoclast-derived zinc finger; in mice, leukemia/lymphoma-related factor) in patients with rheumatoid arthritis (RA), and assessed its role in osteoclastogenesis in vivo. Expression of FBI-1/OCZF was investigated in subchondral osteoclasts in human RA and in rat adjuvant-induced arthritis (AIA) using immunostaining and in situ hybridization, respectively. Transgenic mice overexpressing OCZF (OCZF-Tg) under the control of the cathepsin K promoter were generated, and bone mineral density and bone histomorphometric features were determined by peripheral quantitative computed tomography, calcein double-labeling, and specific staining for osteoclasts and osteoblasts. LRF/OCZF expression and the consequence of LRF inhibition were assessed in vitro with RANKL-induced osteoclast differentiation. FBI-1/OCZF was detected in the nuclei of osteoclasts in rat AIA and human RA. RANKL increased the levels of LRF messenger RNA and nuclear-localized LRF protein in primary macrophages. In OCZF-Tg mice, bone volume was significantly decreased, the number of osteoclasts, but not osteoblasts, was increased in long bones, and osteoclast survival was promoted. Conversely, inhibition of LRF expression suppressed the formation of osteoclasts from macrophages in vitro. FBI-1/OCZF/LRF regulates osteoclast formation and apoptosis in vivo, and may become a useful marker and target in treating disorders leading to reduced bone density, including chronic arthritis. Copyright © 2011 by the American College of Rheumatology.

Repeatability of Non-Contrast-Enhanced Lower-Extremity Angiography Using the Flow-Spoiled Fresh Blood Imaging.

PubMed

Zhang, Yuyang; Xing, Zhen; She, Dejun; Huang, Nan; Cao, Dairong

The aim of this study was to prospectively evaluate the repeatability of non-contrast-enhanced lower-extremity magnetic resonance angiography using the flow-spoiled fresh blood imaging (FS-FBI). Forty-three healthy volunteers and 15 patients with lower-extremity arterial stenosis were recruited in this study and were examined by FS-FBI. Digital subtraction angiography was performed within a week after the FS-FBI in the patient group. Repeatability was assessed by the following parameters: grading of image quality, diameter and area of major arteries, and grading of stenosis of lower-extremity arteries. Two experienced radiologists blinded for patient data independently evaluated the FS-FBI and digital subtraction angiography images. Intraclass correlation coefficients (ICCs), sensitivity, and specificity were used for statistical analysis. The grading of image quality of most data was satisfactory. The ICCs for the first and second measures were 0.792 and 0.884 in the femoral segment and 0.803 and 0.796 in the tibiofibular segment for healthy volunteer group, 0.873 and 1.000 in the femoral segment, and 0.737 and 0.737 in the tibiofibular segment for the patient group. Intraobserver and interobserver agreements on diameter and area of arteries were excellent, with ICCs mostly greater than 0.75 in the volunteer group. For stenosis grading analysis, intraobserver ICCs range from 0.784 to 0.862 and from 0.778 to 0.854, respectively. Flow-spoiled fresh blood imaging yielded a mean sensitivity and specificity to detect arterial stenosis or occlusion of 90% and 80% for femoral segment and 86.7% and 93.3% for tibiofibular segment at least. Lower-extremity angiography with FS-FBI is a reliable and reproducible screening tool for lower-extremity atherosclerotic disease, especially for patients with impaired renal function.

Optimum design of bridges with superelastic-friction base isolators against near-field earthquakes

NASA Astrophysics Data System (ADS)

Ozbulut, Osman E.; Hurlebaus, Stefan

2010-04-01

The seismic response of a multi-span continuous bridge isolated with novel superelastic-friction base isolator (S-FBI) is investigated under near-field earthquakes. The isolation system consists of a flat steel-Teflon sliding bearing and a superelastic NiTi shape memory alloy (SMA) device. Sliding bearings limit the maximum seismic forces transmitted to the superstructure to a certain value that is a function of friction coefficient of sliding interface. Superelastic SMA device provides restoring capability to the isolation system together with additional damping characteristics. The key design parameters of an S-FBI system are the natural period of the isolated, yielding displacement of SMA device, and the friction coefficient of the sliding bearings. The goal of this study is to obtain optimal values for each design parameter by performing sensitivity analyses of the isolated bridge. First, a three-span continuous bridge is modeled as a two-degrees-of-freedom with S-FBI system. A neuro-fuzzy model is used to capture rate-dependent nonlinear behavior of SMA device. A time-dependent method which employs wavelets to adjust accelerograms to match a target response spectrum with minimum changes on the other characteristics of ground motions is used to generate ground motions used in the simulations. Then, a set of nonlinear time history analyses of the isolated bridge is performed. The variation of the peak response quantities of the isolated bridge is shown as a function of design parameters. Also, the influence of temperature variations on the effectiveness of S-FBI system is evaluated. The results show that the optimum design of the isolated bridge with S-FBI system can be achieved by a judicious specification of design parameters.

Link Correlation Based Transmit Sector Antenna Selection for Alamouti Coded OFDM

NASA Astrophysics Data System (ADS)

Ahn, Chang-Jun

In MIMO systems, the deployment of a multiple antenna technique can enhance the system performance. However, since the cost of RF transmitters is much higher than that of antennas, there is growing interest in techniques that use a larger number of antennas than the number of RF transmitters. These methods rely on selecting the optimal transmitter antennas and connecting them to the respective. In this case, feedback information (FBI) is required to select the optimal transmitter antenna elements. Since FBI is control overhead, the rate of the feedback is limited. This motivates the study of limited feedback techniques where only partial or quantized information from the receiver is conveyed back to the transmitter. However, in MIMO/OFDM systems, it is difficult to develop an effective FBI quantization method for choosing the space-time, space-frequency, or space-time-frequency processing due to the numerous subchannels. Moreover, MIMO/OFDM systems require antenna separation of 5 ∼ 10 wavelengths to keep the correlation coefficient below 0.7 to achieve a diversity gain. In this case, the base station requires a large space to set up multiple antennas. To reduce these problems, in this paper, we propose the link correlation based transmit sector antenna selection for Alamouti coded OFDM without FBI.

POZ domain transcription factor, FBI-1, represses transcription of ADH5/FDH by interacting with the zinc finger and interfering with DNA binding activity of Sp1.

PubMed

Lee, Dong-Kee; Suh, Dongchul; Edenberg, Howard J; Hur, Man-Wook

2002-07-26

The POZ domain is a protein-protein interaction motif that is found in many transcription factors, which are important for development, oncogenesis, apoptosis, and transcription repression. We cloned the POZ domain transcription factor, FBI-1, that recognizes the cis-element (bp -38 to -22) located just upstream of the core Sp1 binding sites (bp -22 to +22) of the ADH5/FDH minimal promoter (bp -38 to +61) in vitro and in vivo, as revealed by electrophoretic mobility shift assay and chromatin immunoprecipitation assay. The ADH5/FDH minimal promoter is potently repressed by the FBI-1. Glutathione S-transferase fusion protein pull-down showed that the POZ domains of FBI-1, Plzf, and Bcl-6 directly interact with the zinc finger DNA binding domain of Sp1. DNase I footprinting assays showed that the interaction prevents binding of Sp1 to the GC boxes of the ADH5/FDH promoter. Gal4-POZ domain fusions targeted proximal to the GC boxes repress transcription of the Gal4 upstream activator sequence-Sp1-adenovirus major late promoter. Our data suggest that POZ domain represses transcription by interacting with Sp1 zinc fingers and by interfering with the DNA binding activity of Sp1.

Stress management in the Federal Bureau of Investigation: principles for program development.

PubMed

Sheehan, S S

1999-01-01

Images from the destruction of the Alfred P. Murrah Federal Building in Oklahoma City, the compound in Waco, Texas, the World Trade Center in New York City, Pan Am Flight 103 over Lockerbie, Scotland, and the American Embassy in Nairobi, Kenya, burned themselves into the public's consciousness as disasters viewed from a distance. Many law enforcement officers and rescue workers experienced those images firsthand. Headlines flash in newspapers, and sound bites blare on the airwaves as many law enforcement professionals suffer in silence. With increasing frequency, such major critical incidents, as well as smaller-scale events such as shootings, accidents, and personal tragedies--which all emergency response personnel encounter throughout their careers--encroach on their daily lives and may cause intense stress reactions. Managers within the Federal Bureau of Investigation (FBI) commit to mitigating the ill effects of stressors on fellow employees. The FBI's Behavioral Science Unit and the Employee Assistance Unit work together to teach FBI employees a three-step process--how to recognize, understand, and cope with the stress in their lives. Given the alarming increase in violence, terrorism, and related crimes, there exists a myriad of organizations as well as other law enforcement agencies which could benefit from a similar formula. This paper describes how the FBI operationalizes stress management.

The Applicability of Army Design Methodology to the Federal Bureau of Investigation

DTIC Science & Technology

2011-05-19

fighting crime , terrorism and espionage, while responding to new threats by organizing, equipping and adapting. Throughout the gangster era of the 1930s...the FBI armed its agents for the first time, and organized itself to fight gangsters who were accustomed to committing violent crimes and crossing...to transform the FBI into an effective domestic intelligence agency with the goal of preventing terrorist attacks and serious crime .7 These efforts

FBI Counterintelligence Visits to Libraries. Hearings before the Subcommittee on Civil and Constitutional Rights of the Committee on the Judiciary. House of Representatives, One Hundredth Congress, Second Session, June 20 and July 13, 1988.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. House Committee on the Judiciary.

Focusing on the Library Awareness Program, these two congressional hearings scrutinize the efforts of the Federal Bureau of Investigation (FBI) to collect counterintelligence data from librarians regarding their patrons. Two examples of proposed legislation to address the question of intellectual privacy and confidentiality are included. Testimony…

Evaluation of modulating field of photoreflectance of surface-intrinsic-n+ type doped GaAs by using photoinduced voltage

NASA Astrophysics Data System (ADS)

Lee, W. Y.; Chien, J. Y.; Wang, D. P.; Huang, K. F.; Huang, T. C.

2002-04-01

Photoreflectance (PR) of surface-intrinsic-n+ type doped GaAs has been measured for various power densities of pump laser. The spectra exhibited many Franz-Keldysh oscillations, whereby the strength of electric field F in the undoped layer can be determined. The thus obtained Fs are subject to photovoltaic effect and are less than built-in field Fbi. In the previous work we have obtained the relation F≈Fbi-δF/2 when δF≪Fbi by using electroreflectance to simulate PR, where δF is the modulating field of the pump beam. In this work a method was devised to evaluate δF by using photoinduced voltages Vs and, hence, the relation can be verified by PR itself. The δFs obtained by Vs are also consistent with those of using imaginary part of fast Fourier transform of PR spectra.

Application of a faith-based integration tool to assess mental and physical health interventions.

PubMed

Saunders, Donna M; Leak, Jean; Carver, Monique E; Smith, Selina A

2017-01-01

To build on current research involving faith-based interventions (FBIs) for addressing mental and physical health, this study a) reviewed the extent to which relevant publications integrate faith concepts with health and b) initiated analysis of the degree of FBI integration with intervention outcomes. Derived from a systematic search of articles published between 2007 and 2017, 36 studies were assessed with a Faith-Based Integration Assessment Tool (FIAT) to quantify faith-health integration. Basic statistical procedures were employed to determine the association of faith-based integration with intervention outcomes. The assessed studies possessed (on average) moderate, inconsistent integration because of poor use of faith measures, and moderate, inconsistent use of faith practices. Analysis procedures for determining the effect of FBI integration on intervention outcomes were inadequate for formulating practical conclusions. Regardless of integration, interventions were associated with beneficial outcomes. To determine the link between FBI integration and intervention outcomes, additional analyses are needed.

Family burden in inherited ichthyosis: creation of a specific questionnaire.

PubMed

Dufresne, Hélène; Hadj-Rabia, Smail; Méni, Cécile; Sibaud, Vincent; Bodemer, Christine; Taïeb, Charles

2013-02-15

The concept of individual burden, associated with disease, has been introduced recently to determine the "disability" caused by the pathology in the broadest sense of the word (psychological, social, economic, physical). Inherited ichthyosis belong to a large heterogeneous group of Mendelian Disorders of Cornification. Skin symptoms have a major impact on patients' Quality of Life but little is known about the burden of the disease on the families of patients. To develop and validate a specific burden questionnaire for the families of patients affected by ichthyosis. Two steps were required. First, the creation of the questionnaire which followed a strict methodological process involving a multidisciplinary team and families. Secondarily, the validation of the questionnaire, including the assessment of its reliability, external validity, reproducibility and sensitivity, was carried out on a population of patients affected by autosomal recessive congenital ichthyosis. A population of parents of patients affected by ichthyosis was enrolled to answer the new questionnaire in association with the Short Form Q12 questionnaire (SF-12) and a clinical severity score was filled for each patient. Ninety four families were interviewed to construct the verbatim in order to create the questionnaire and a cognitive debriefing was realized. The concept of burden could be structured around five components: "economic", "daily life", "familial and personal relationship", "work", and "psychological impact". As a result, "Family Burden Ichthyosis" (FBI) reproducible questionnaire of 25 items was created.Forty two questionnaires were analyzable for psychometric validation. Reliability (Cronbach's alpha coefficient = 0.89), reflected the good homogeneity of the questionnaire. The correlation between mental dimensions of the SF-12 and the FBI questionnaire was statistically significant which confirmed the external validity. The mean FBI score was 71.7 ± 18.8 and a significant difference in the FBI score was shown between two groups of severity underlining a good sensitivity of the questionnaire. The internal and external validity of the "FBI" questionnaire was confirmed and it is correlated to the severity of ichtyosis. Ichthyoses, and other chronic pathologies, are difficult to assess by clinical or Quality of Life aspects alone as their impact can be multidimensional. "FBI" takes them all into consideration in order to explain every angle of the handicap generated.

China: Suspected Acquisition of U.S. Nuclear Weapon Secrets

DTIC Science & Technology

2006-02-01

Benjamin Kang, “China Nuclear Halt May Stem From Deal,” Reuters, July 30, 1996; Robert Karniol, “Nuclear Blast Heralds A Chinese Moratorium,” Jane’s Defense...Leak,” New York Times, April 8, 1999. 12 FBI, “Statement by FBI Director Robert S. Mueller,” April 9, 2003; Katrina Leung Affidavit; James J. Smith...the appropriate congressional committees and the White House on April 21, 1999. Robert Walpole, the National Intelligence Officer for Strategic and

Toward an integrated view of ionospheric plasma instabilities: Altitudinal transitions and strong gradient case

NASA Astrophysics Data System (ADS)

Makarevich, Roman A.

2016-04-01

A general dispersion relation is derived that integrates the Farley-Buneman, gradient-drift, and current-convective plasma instabilities (FBI, GDI, and CCI) within the same formalism for an arbitrary altitude, wave propagation vector, and background density gradient. The limiting cases of the FBI/GDI in the E region for nearly field-aligned irregularities, GDI/CCI in the main F region at long wavelengths, and GDI at high altitudes are successfully recovered using analytic analysis. Numerical solutions are found for more general representative cases spanning the entire ionosphere. It is demonstrated that the results are consistent with those obtained using a general FBI/GDI/CCI theory developed previously at and near E region altitudes under most conditions. The most significant differences are obtained for strong gradients (scale lengths of 100 m) at high altitudes such as those that may occur during highly structured soft particle precipitation events. It is shown that the strong gradient case is dominated by inertial effects and, for some scales, surprisingly strong additional damping due to higher-order gradient terms. The growth rate behavior is examined with a particular focus on the range of wave propagations with positive growth (instability cone) and its transitions between altitudinal regions. It is shown that these transitions are largely controlled by the plasma density gradients even when FBI is operational.

Trajectories of Behavioural Disturbances Across Dementia Types.

PubMed

Linds, Alexandra B; Kirstein, Alana B; Freedman, Morris; Verhoeff, Nicolaas P L G; Wolf, Uri; Chow, Tiffany W

2015-11-01

To replicate a previous finding that the trajectory of the Neuropsychiatric Inventory (NPI) shifts in the sixth year of behavioural variant frontotemporal dementia (bvFTD). We evaluated longitudinal tracking with both the Frontal Behavioural Inventory (FBI) and NPI, comparing bvFTD against other dementias. Chart reviews over two to five years for patients with bvFTD (n=30), primary progressive aphasia (PPA, n=13) and Alzheimer's disease (AD, n=118) at an urban Canadian tertiary clinic specializing in dementia. Linear regressions of the longitudinal data tested predictors of annualized rates of change (ROC) in NPI and FBI total and subscales for apathy and disinhibition among dementia groups. The mode of the overall sample for the most advanced duration of illness observed was 5 years, with the median at 7 years. We did not find a crescendo-decrescendo pattern in scores although, for bvFTD and AD, high initial scores correlated with ensuing downward ROCs on the NPI and FBI. Educational level showed an influence on disinhibition ROCs. The FBI was no more revealing than the NPI for apathy and disinhibition scores in these dementias. A cognitive reserve effect on behavioural disturbance was supported but it may take longer than our 4 years of observing the clinical sample to record inflection points in the behavioural and psychiatric symptoms seen in bvFTD. The current data only imply that both apathy and disinhibition will diminish over the course of dementia.

Low-Speed Fingerprint Image Capture System User`s Guide, June 1, 1993

DOE Office of Scientific and Technical Information (OSTI.GOV)

Whitus, B.R.; Goddard, J.S.; Jatko, W.B.

1993-06-01

The Low-Speed Fingerprint Image Capture System (LS-FICS) uses a Sun workstation controlling a Lenzar ElectroOptics Opacity 1000 imaging system to digitize fingerprint card images to support the Federal Bureau of Investigation`s (FBI`s) Automated Fingerprint Identification System (AFIS) program. The system also supports the operations performed by the Oak Ridge National Laboratory- (ORNL-) developed Image Transmission Network (ITN) prototype card scanning system. The input to the system is a single FBI fingerprint card of the agreed-upon standard format and a user-specified identification number. The output is a file formatted to be compatible with the National Institute of Standards and Technology (NIST)more » draft standard for fingerprint data exchange dated June 10, 1992. These NIST compatible files contain the required print and text images. The LS-FICS is designed to provide the FBI with the capability of scanning fingerprint cards into a digital format. The FBI will replicate the system to generate a data base of test images. The Host Workstation contains the image data paths and the compression algorithm. A local area network interface, disk storage, and tape drive are used for the image storage and retrieval, and the Lenzar Opacity 1000 scanner is used to acquire the image. The scanner is capable of resolving 500 pixels/in. in both x and y directions. The print images are maintained in full 8-bit gray scale and compressed with an FBI-approved wavelet-based compression algorithm. The text fields are downsampled to 250 pixels/in. and 2-bit gray scale. The text images are then compressed using a lossless Huffman coding scheme. The text fields retrieved from the output files are easily interpreted when displayed on the screen. Detailed procedures are provided for system calibration and operation. Software tools are provided to verify proper system operation.« less

Repeatability of Non–Contrast-Enhanced Lower-Extremity Angiography Using the Flow-Spoiled Fresh Blood Imaging

PubMed Central

Zhang, Yuyang; Xing, Zhen; She, Dejun; Huang, Nan; Cao, Dairong

2018-01-01

Purpose The aim of this study was to prospectively evaluate the repeatability of non–contrast-enhanced lower-extremity magnetic resonance angiography using the flow-spoiled fresh blood imaging (FS-FBI). Methods Forty-three healthy volunteers and 15 patients with lower-extremity arterial stenosis were recruited in this study and were examined by FS-FBI. Digital subtraction angiography was performed within a week after the FS-FBI in the patient group. Repeatability was assessed by the following parameters: grading of image quality, diameter and area of major arteries, and grading of stenosis of lower-extremity arteries. Two experienced radiologists blinded for patient data independently evaluated the FS-FBI and digital subtraction angiography images. Intraclass correlation coefficients (ICCs), sensitivity, and specificity were used for statistical analysis. Results The grading of image quality of most data was satisfactory. The ICCs for the first and second measures were 0.792 and 0.884 in the femoral segment and 0.803 and 0.796 in the tibiofibular segment for healthy volunteer group, 0.873 and 1.000 in the femoral segment, and 0.737 and 0.737 in the tibiofibular segment for the patient group. Intraobserver and interobserver agreements on diameter and area of arteries were excellent, with ICCs mostly greater than 0.75 in the volunteer group. For stenosis grading analysis, intraobserver ICCs range from 0.784 to 0.862 and from 0.778 to 0.854, respectively. Flow-spoiled fresh blood imaging yielded a mean sensitivity and specificity to detect arterial stenosis or occlusion of 90% and 80% for femoral segment and 86.7% and 93.3% for tibiofibular segment at least. Conclusions Lower-extremity angiography with FS-FBI is a reliable and reproducible screening tool for lower-extremity atherosclerotic disease, especially for patients with impaired renal function. PMID:28787351

Effects of green tea catechins with or without caffeine on glycemic control in adults: a meta-analysis of randomized controlled trials.

PubMed

Zheng, Xin-Xin; Xu, Yan-Lu; Li, Shao-Hua; Hui, Rutai; Wu, Yong-Jian; Huang, Xiao-Hong

2013-04-01

The effect of green tea catechins (GTCs) with or without caffeine on glycemic control is controversial. We aimed to identify and quantify the effects of GTCs or GTC-caffeine mixtures on glucose metabolism in adults. A comprehensive literature search was conducted to identify relevant trials of GTCs with or without caffeine on markers of glycemic control [fasting blood glucose (FBG), fasting blood insulin (FBI), glycated hemoglobin (Hb A1c), and homeostatic model assessment of insulin resistance (HOMA-IR)]. Weighted mean differences were calculated for net changes by using fixed-effects models. Prespecified subgroup analyses were performed to explore the influence of covariates on net changes in FBG and FBI concentrations. Twenty-two eligible randomized controlled trials with 1584 subjects were identified. Pooled analyses showed that FBG (-1.48 mg/dL; 95% CI: -2.57, -0.40 mg/dL) decreased significantly with GTCs with or without caffeine, whereas FBI (0.04 μU/mL; 95% CI: -0.36, 0.45 μU/mL), Hb A1c (-0.04%; 95% CI: -0.15, 0.08%), and HOMA-IR (-0.05; 95% CI: -0.37, 0.26) did not. Subgroup analyses indicated that the glucose-lowering effect was apparent when the duration of follow-up was over a median of 12 wk. Overall, no significant heterogeneity was detected for FBG, FBI, Hb A1c, or HOMA-IR. The meta-analysis showed that the administration of GTCs with or without caffeine resulted in a significant reduction in FBG. The limited data available on GTCs did not support a positive effect on FBI, Hb A1c, or HOMA-IR. Thus, more large and well-designed trials are needed in the future. This trial was registered at http://www.crd.york.ac.uk/prospero as CRD42012002139.

Application of a faith-based integration tool to assess mental and physical health interventions

PubMed Central

Saunders, Donna M.; Leak, Jean; Carver, Monique E.; Smith, Selina A.

2017-01-01

Background To build on current research involving faith-based interventions (FBIs) for addressing mental and physical health, this study a) reviewed the extent to which relevant publications integrate faith concepts with health and b) initiated analysis of the degree of FBI integration with intervention outcomes. Methods Derived from a systematic search of articles published between 2007 and 2017, 36 studies were assessed with a Faith-Based Integration Assessment Tool (FIAT) to quantify faith-health integration. Basic statistical procedures were employed to determine the association of faith-based integration with intervention outcomes. Results The assessed studies possessed (on average) moderate, inconsistent integration because of poor use of faith measures, and moderate, inconsistent use of faith practices. Analysis procedures for determining the effect of FBI integration on intervention outcomes were inadequate for formulating practical conclusions. Conclusions Regardless of integration, interventions were associated with beneficial outcomes. To determine the link between FBI integration and intervention outcomes, additional analyses are needed. PMID:29354795

Farley-Buneman Instability in the Solar Chromosphere

NASA Astrophysics Data System (ADS)

Gogoberidze, G.; Voitenko, Y.; Poedts, S.; Goossens, M.

2009-11-01

The Farley-Buneman instability (FBI) is studied in the partially ionized plasma of the solar chromosphere taking into account the finite magnetization of the ions and Coulomb collisions. We obtain the threshold value for the relative velocity between ions and electrons necessary for the instability to develop. It is shown that Coulomb collisions play a destabilizing role in the sense that they enable the instability even in the regions where the ion magnetization is larger than unity. By applying these results to chromospheric conditions, we show that the FBI cannot be responsible for the quasi-steady heating of the solar chromosphere. However, we do not exclude the instability development locally in the presence of strong cross-field currents and/or strong small-scale magnetic fields. In such cases, FBI should produce locally small-scale, ~0.1-3 m, density irregularities in the solar chromosphere. These irregularities can cause scintillations of radio waves with similar wave lengths and provide a tool for remote chromospheric sensing.

FARLEY-BUNEMAN INSTABILITY IN THE SOLAR CHROMOSPHERE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gogoberidze, G.; Voitenko, Y.; Poedts, S.

2009-11-20

The Farley-Buneman instability (FBI) is studied in the partially ionized plasma of the solar chromosphere taking into account the finite magnetization of the ions and Coulomb collisions. We obtain the threshold value for the relative velocity between ions and electrons necessary for the instability to develop. It is shown that Coulomb collisions play a destabilizing role in the sense that they enable the instability even in the regions where the ion magnetization is larger than unity. By applying these results to chromospheric conditions, we show that the FBI cannot be responsible for the quasi-steady heating of the solar chromosphere. However,more » we do not exclude the instability development locally in the presence of strong cross-field currents and/or strong small-scale magnetic fields. In such cases, FBI should produce locally small-scale, approx0.1-3 m, density irregularities in the solar chromosphere. These irregularities can cause scintillations of radio waves with similar wave lengths and provide a tool for remote chromospheric sensing.« less

Rapid Identification and Assignation of the Active Ingredients in Fufang Banbianlian Injection Using HPLC-DAD-ESI-IT-TOF-MS.

PubMed

Li, Sensen; Lin, Zongtao; Jiang, Haixiu; Tong, Lingkun; Wang, Hong; Chen, Shizhong

2016-08-01

Fufang Banbianlian Injection (FBI) is a well-known traditional Chinese medicine formula composed of three herbal medicines. However, the systematic investigation on its chemical components has not been reported yet. In this study, a high-performance liquid chromatography combined with diode-array detector, and coupled to an electrospray ionization with ion-trap time-of-flight mass spectrometry (HPLC-DAD-ESI-IT-TOF-MS) method, was established for the identification of chemical profile in FBI. Sixty-six major constituents (14 phenolic acids, 14 iridoids, 20 flavonoids, 2 benzylideneacetone compounds, 3 phenylethanoid glycosides, 1 coumarin, 1 lignan, 3 nucleosides, 1 amino acids, 1 monosaccharides, 2 oligosaccharides, 3 alduronic acids and citric acid) were identified or tentatively characterized by comparing their retention times and MS spectra with those of standards or literature data. Finally, all constituents were further assigned in the individual herbs (InHs), although some of them were from multiple InHs. As a result, 11 compounds were from Lobelia chinensis Lour, 33 compounds were from Scutellaria barbata D. Don and 38 compounds were from Hedyotis diffusa Willd. In conclusion, the developed HPLC-DAD-ESI-IT-TOF-MS method is a rapid and efficient technique for analysis of FBI sample, and could be a valuable method for the further study on the quality control of the FBI. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

FBI fingerprint identification automation study: AIDS 3 evaluation report. Volume 5: Current system evaluation

NASA Technical Reports Server (NTRS)

Mulhall, B. D. L.

1980-01-01

The performance, costs, organization and other characteristics of both the manual system and AIDS 2 were used to establish a baseline case. The results of the evaluation are to be used to determine the feasibility of the AIDS 3 System, as well as provide a basis for ranking alternative systems during the second phase of the JPL study. The results of the study were tabulated by subject, scope and methods, providing a descriptive, quantitative and qualitative analysis of the current operating systems employed by the FBI Identification Division.

The Einstein Dossiers: Science and Politics - Einstein's Berlin Period with an Appendix on Einstein's FBI File

NASA Astrophysics Data System (ADS)

Grundmann, Siegfried

In 1919 the Prussian Ministry of Science, Arts and Culture opened a dossier on "Einstein's Theory of Relativity." It was rediscovered by the author in 1961 and is used in conjunction with numerous other subsequently identified 'Einstein' files as the basis of this fascinating book. In particular, the author carefully scrutinizes Einstein's FBI file from 1950-55 against mostly unpublished material from European including Soviet sources and presents hitherto unknown documentation on Einstein's alleged contacts with the German Communist Party and the Comintern.

Bulk Superconductivity Induced by Se Substitution in BiCh2-Based Layered Compounds Eu0.5Ce0.5FBiS2-xSex

NASA Astrophysics Data System (ADS)

Goto, Yosuke; Sogabe, Ryota; Mizuguchi, Yoshikazu

2017-10-01

We report the effect of Se substitution on the crystal structure and superconductivity of BiCh2-based (Ch: S, Se) layered compounds Eu0.5Ce0.5FBiS2-xSex (x = 0-1). Crystal structure analysis showed that both lattice constants, a and c, increased with increasing x, which is different from the related La-doped system Eu0.5La0.5FBiS2-xSex. This is due to Se substitution at both in-plane and out-of-plane Ch sites in the present Ce-doped system. Zero resistivity was observed for x = 0.2-1 above 2 K. The superconducting properties of Eu0.5Ce0.5FBiS2-xSex were investigated by magnetic susceptibility measurement, and the highest superconducting transition temperature of 3.5 K was obtained for x = 0.6 with a large shielding volume fraction. The emergence of bulk superconductivity and metallic conductivity can be qualitatively described in terms of the increased in-plane chemical pressure effect. A magnetic anomaly below 8 K, probably because of the ferromagnetic order of the magnetic moment of Ce3+ ions, coexists with bulk superconductivity in the BiCh2 layer. Since the effect of Se substitution on the magnetic transition temperature is ignorable, we suggest that the coupling between the magnetic order at the (Eu,Ce)F layer and the superconductivity at the Bi(S,Se)2 layer is weak.

Focused Board Intervention (FBI): A Remediation Program for Written Board Preparation and the Medical Knowledge Core Competency.

PubMed

Visconti, Annette; Gaeta, Theodore; Cabezon, Michael; Briggs, William; Pyle, Matthew

2013-09-01

Residents deemed at risk for low performance on standardized examinations require focused attention and remediation. To determine whether a remediation program for residents identified as at risk for failure on the Emergency Medicine (EM) Written Board Examination is associated with improved outcomes. All residents in 8 classes of an EM 1-3 program were assessed using the In-Training Examination. Residents enrolled in the Focused Board Intervention (FBI) remediation program based on an absolute score on the EM 3 examination of <70% or a score more than 1 SD below the national mean on the EM 1 or 2 examination. Individualized education plans (IEPs) were created for residents in the FBI program, combining self-study audio review lectures with short-answer examinations. The association between first-time pass rate for the American Board of Emergency Medicine (ABEM) Written Qualifying Examination (WQE) and completion of all IEPs was examined using the χ(2) test. Of the 64 residents graduating and sitting for the ABEM examination between 2000 and 2008, 26 (41%) were eligible for the program. Of these, 10 (38%) residents were compliant and had a first-time pass rate of 100%. The control group (12 residents who matched criteria but graduated before the FBI program was in place and 4 who were enrolled but failed to complete the program) had a 44% pass rate (7 of 16), which was significantly lower (χ(2)  =  8.6, P  =  .003). The probability of passing the ABEM WQE on the first attempt was improved through the completion of a structured IEP.

New method to calculate the N2 evolution from mixed venous blood during the N2 washout.

PubMed

Han, D; Jeng, D R; Cruz, J C; Flores, X F; Mallea, J M

2001-08-01

To model the normalized phase III slope (Sn) from N2 expirograms of the multibreath N2 washout is a challenge to researchers. Experimental measurements show that Sn increases with the number of breaths. Previously, we predicted Sn by setting the concentration (atm) of mixed venous blood (Fbi,N2) to a constant value of 0.3 after the fifth breath to calculate the amount of N2 transferred from the blood to the alveoli. As a consequence, the predicted curve of the Sn values showed a maximum before the quasi-steady state was reached. In this paper, we present a way of calculating the amount of N2 transferred from the blood to the alveoli by setting Fbi,N2 in the following way: In the first six breaths Fbi,N2 is kept constant at the initial value of 0.8 because circulation time needs at least 30 s to alter it. Thereafter, a single exponential function with respect the number of breaths is used: Fbi = 0.8 exp[0.112(6-n)], in which n is the breath number. The predicted Sn values were compared with experimental data from the literature. The assumption of an exponential decay in the N2 evolved from mixed venous blood is important in determining the shape of the Sn curve but new experimental data are needed to determine the validity of the model. We concluded that this new approach to calculate the N2 evolution from the blood is more meaningful physiologically.

A glance into how the cold war and governmental loyalty investigations came to affect a leading U.S. radiation geneticist: Lewis J. Stadler's nightmare.

PubMed

Calabrese, Edward J

2017-10-30

This paper describes an episode in the life of the prominent plant radiation geneticist, Lewis J. Stadler (1897-1954) during which he became a target of the Federal Bureau of Investigation (FBI) concerning loyalty to the United States due to possible associations with the communist party. The research is based on considerable private correspondence of Dr. Stadler, the FBI interrogatory questions and Dr. Stadler's answers and letters of support for Dr. Stadler by leading scientists such as, Hermann J. Muller.

FBI fingerprint identification automation study: AIDS 3 evaluation report. Volume 8: Measures of effectiveness

NASA Technical Reports Server (NTRS)

Mulhall, B. D. L.

1980-01-01

The development of both quantitative criteria that were used to evaluate conceptional systems for automating the functions for the FBI Identification Division is described. Specific alternative systems for automation were compared by using these developed criteria, defined as Measures of Effectiveness (MOE), to gauge system's performance in attempting to achieve certain goals. The MOE, essentially measurement tools that were developed through the combination of suitable parameters, pertain to each conceivable area of system operation. The methods and approaches used, both in selecting the parameters and in using the resulting MOE, are described.

Delamanid susceptibility testing of Mycobacterium tuberculosis using the resazurin microtitre assay and the BACTEC™ MGIT™ 960 system.

PubMed

Schena, Elisa; Nedialkova, Lubov; Borroni, Emanuele; Battaglia, Simone; Cabibbe, Andrea Maurizio; Niemann, Stefan; Utpatel, Christian; Merker, Matthias; Trovato, Alberto; Hofmann-Thiel, Sabine; Hoffmann, Harald; Cirillo, Daniela Maria

2016-06-01

The objective of this study was to develop standardized protocols for rapid delamanid drug susceptibility testing (DST) using the colorimetric resazurin microtitre assay (REMA) and semi-automated BACTEC™ MGIT™ 960 system (MGIT) by establishing breakpoints that accurately discriminate between susceptibility and resistance of Mycobacterium tuberculosis to delamanid. MICs of delamanid were determined by the MGIT, the REMA and the solid agar method for 19 pre-characterized strains. The MIC distribution of delamanid was then established for a panel of clinical strains never exposed to the drug and characterized by different geographical origins and susceptibility patterns. WGS was used to investigate genetic polymorphisms in five genes (ddn, fgd1, fbiA, fbiB and fbiC) involved in intracellular delamanid activation. We demonstrated that the REMA and MGIT can both be used for the rapid and accurate determination of delamanid MIC, showing excellent concordance with the solid agar reference method, as well as high reproducibility and repeatability. We propose the tentative breakpoint of 0.125 mg/L for the REMA and MGIT, allowing reliable discrimination between M. tuberculosis susceptible and resistant to delamanid. Stop codon mutations in ddn (Trp-88 → STOP) and fbiA (Lys-250 → STOP) have only been observed in strains resistant to delamanid. We established protocols for DST of delamanid in the MGIT and REMA, confirming their feasibility in routine TB diagnostics, utilizing the same discriminative concentration for both methods. Moreover, taking advantage of WGS analysis, we identified polymorphisms potentially associated with resistance in two genes involved in delamanid activation. © The Author 2016. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

In Vitro and In Vivo Human Metabolism of Synthetic Cannabinoids FDU-PB-22 and FUB-PB-22.

PubMed

Diao, Xingxing; Scheidweiler, Karl B; Wohlfarth, Ariane; Pang, Shaokun; Kronstrand, Robert; Huestis, Marilyn A

2016-03-01

In 2014, FDU-PB-22 and FUB-PB-22, two novel synthetic cannabinoids, were detected in herbal blends in Japan, Russia, and Germany and were quickly added to their scheduled drugs list. Unfortunately, no human metabolism data are currently available, making it challenging to confirm their intake. The present study aims to identify appropriate analytical markers by investigating FDU-PB-22 and FUB-PB-22 metabolism in human hepatocytes and confirm the results in authentic urine specimens. For metabolic stability, 1 μM FDU-PB-22 and FUB-PB-22 was incubated with human liver microsomes for up to 1 h; for metabolite profiling, 10 μM was incubated with human hepatocytes for 3 h. Two authentic urine specimens from FDU-PB-22 and FUB-PB-22 positive cases were analyzed after β-glucuronidase hydrolysis. Metabolite identification in hepatocyte samples and urine specimens was accomplished by high-resolution mass spectrometry using information-dependent acquisition. Both FDU-PB-22 and FUB-PB-22 were rapidly metabolized in HLM with half-lives of 12.4 and 11.5 min, respectively. In human hepatocyte samples, we identified seven metabolites for both compounds, generated by ester hydrolysis and further hydroxylation and/or glucuronidation. After ester hydrolysis, FDU-PB-22 and FUB-PB-22 yielded the same metabolite M7, fluorobenzylindole-3-carboxylic acid (FBI-COOH). M7 and M6 (hydroxylated FBI-COOH) were the major metabolites. In authentic urine specimens after β-glucuronidase hydrolysis, M6 and M7 also were the predominant metabolites. Based on our study, we recommend M6 (hydroxylated FBI-COOH) and M7 (FBI-COOH) as suitable urinary markers for documenting FDU-PB-22 and/or FUB-PB-22 intake.

Peak finding using biorthogonal wavelets

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tan, C.Y.

2000-02-01

The authors show in this paper how they can find the peaks in the input data if the underlying signal is a sum of Lorentzians. In order to project the data into a space of Lorentzian like functions, they show explicitly the construction of scaling functions which look like Lorentzians. From this construction, they can calculate the biorthogonal filter coefficients for both the analysis and synthesis functions. They then compare their biorthogonal wavelets to the FBI (Federal Bureau of Investigations) wavelets when used for peak finding in noisy data. They will show that in this instance, their filters perform muchmore » better than the FBI wavelets.« less

Evolution of Eu valence and superconductivity in layered Eu0.5La0.5FBiS2 -xSex system

NASA Astrophysics Data System (ADS)

Mizuguchi, Y.; Paris, E.; Wakita, T.; Jinno, G.; Puri, A.; Terashima, K.; Joseph, B.; Miura, O.; Yokoya, T.; Saini, N. L.

2017-02-01

We have studied the effect of Se substitution on Eu valence in a layered Eu0.5La0.5FBiS2 -xSex superconductor using a combined analysis of x-ray absorption near-edge structure (XANES) and x-ray photoelectron spectroscopy (XPS) measurements. Eu L3-edge XANES spectra reveal that Eu is in the mixed valence state with coexisting Eu2 + and Eu3 +. The average Eu valence decreases sharply from ˜2.3 for x =0.0 to ˜2.1 for x =0.4 . Consistently, Eu 3 d XPS shows a clear decrease in the average valence by Se substitution. Bi 4 f XPS indicates that effective charge carriers in the BiCh2 (Ch = S, Se) layers are slightly increased by Se substitution. On the basis of the present results it has been discussed that the metallic character induced by Se substitution in Eu0.5La0.5FBiS2 -xSex is likely to be due to increased in-plane orbital overlap driven by reduced in-plane disorder that affects the carrier mobility.

The UCSF screening exam effectively screens cognitive and behavioral impairment in patients with ALS.

PubMed

Murphy, Jennifer; Ahmed, Fizaa; Lomen-Hoerth, Catherine

2015-03-01

The University of California San Francisco (UCSF) Screening Battery provides clinicians with a uniquely tailored tool to measure ALS patients' cognitive and behavioral changes, adjusting for dysarthria and hand weakness. The battery consists of the ALS-CBS ( 1 ), Written Fluency Test ( 2 ), and a new revision of the Frontal Behavior Inventory (FBI-ALS) ( 3 ). The validity of each component was tested by comparing results with a gold standard neuropsychological exam (GNE). Consensus criteria-based GNE diagnoses ( 4 ) were assigned (n = 24) and concurrent validity was tested for each screening exam component. Results showed that each of the four cognitive and behavioral screening test components were significantly associated with diagnoses confirmed by GNE. GNE diagnoses were significantly associated with FBI-ALS negative score, written S-words score, and ALS-CBS cognitive score. The total FBI-ALS score and C-words tests were less predictive of GNE-diagnosed impairment. In conclusion, the UCSF Cognitive Screening Battery demonstrates good external validity compared with GNE in this modest sample, encouraging its use in larger investigations. These data suggest that this battery may provide an effective screen to identify ALS patients who will then benefit from a full examination to confirm their diagnosis.

Evaluating Kurtosis-based Diffusion MRI Tissue Models for White Matter with Fiber Ball Imaging

PubMed Central

Jensen, Jens H.; McKinnon, Emilie T.; Glenn, G. Russell; Helpern, Joseph A.

2018-01-01

In order to quantify well-defined microstructural properties of brain tissue from diffusion MRI (dMRI) data, tissue models are typically employed that relate biological features, such as cell morphology and cell membrane permeability, to the diffusion dynamics. A variety of such models have been proposed for white matter, and their validation is a topic of active interest. In this paper, three different tissue models are tested by comparing their predictions for a specific microstructural parameter to the value measured independently with a recently proposed dMRI method known as fiber ball imaging (FBI). The three tissue models are all constructed with the diffusion and kurtosis tensors, and they are hence compatible with diffusional kurtosis imaging (DKI). Nevertheless, the models differ significantly in their details and predictions. For voxels with fractional anisotropies (FA) exceeding 0.5, all three are reasonably consistent with FBI. However, for lower FA values, one of these, called the white matter tract integrity (WMTI) model, is found to be in much better accord with FBI than the other two, suggesting that the WMTI model has a broader range of applicability. PMID:28085211

Clinical and radiological outcomes of lumbar posterior subtraction osteotomies are correlated to pelvic incidence and FBI index : Prospective series of 63 cases.

PubMed

Cogniet, A; Aunoble, S; Rigal, J; Demezon, H; Sadikki, R; Le Huec, J C

2016-08-01

Pedicle subtraction osteotomy (PSO) is one of the surgical options for treating alignment disorders of the fused spine (due to post-surgical fusion or related to arthritis). It enables satisfactory sagittal realignment and improved function due to economic sagittal balance. The aim of this study was to analyze clinical and radiological results of PSO after a minimum follow-up of 2 years and demonstrate the benefit of sub-group analysis as a function of pelvic incidence (PI). A descriptive prospective single center study of 63 patients presenting with spinal global malalignment who underwent correction by PSO. Function was assessed by the Oswestry disability index (ODI), a visual analog scale of lumbar pain (VAS) and a SF-36 questionnaire. Radiographic analyses of pre- and post-operative pelvic-spinal parameters were performed on X-rays obtained by EOS(®) imaging after 3D modeling. Global analysis and analysis of sub-groups as a function of pelvic incidence were performed and the full balance integrated index (FBI) was calculated. this series showed a marked clinical improvement and significant progress of functional scores. Global post-operative radiological analysis showed a significant improvement in all pelvic and spinal parameters. The mean correction obtained after PSO was 31.7° ± 8.4°, hence global improvement of lumbar lordosis of 22°. The sagittal vertical angle (SVA) decreased from +9 cm before surgery to +4.3 cm after surgery. Sub-group analysis demonstrated greater improvement in pelvic tilt, sacral slope and spinal parameters of patients with a small or moderate pelvic incidence; all had an FBI index <10°. Most of the pelvic and spinal parameters of patients with a large pelvic incidence were insufficiently corrected and they had an FBI index >10° PSO is a surgical procedure enabling correction of multiplane rigid spinal deformities that require major sagittal correction. It was seen to be highly effective in patients with a small or moderate pelvic incidence (PI <60°) but was sometimes less effective in patients with large pelvic incidence due to insufficient lordosis correction. Clinical results were highly correlated with the value of the FBI index.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nichols, T.

The Nuclear Forensics Analysis Center (NFAC) is part of Savannah River National Laboratory (SRNL) and is one of only two USG National Laboratories accredited to perform nuclear forensic analyses to the requirements of ISO 17025. SRNL NFAC is capable of analyzing nuclear and radiological samples from bulk material to ultra-trace samples. NFAC provides analytical support to the FBI's Radiological Evidence Examination Facility (REEF), which is located within SRNL. REEF gives the FBI the capability to perform traditional forensics on material that is radiological and/or is contaminated. SRNL is engaged in research and development efforts to improve the USG technical nuclearmore » forensics capabilities. Research includes improving predictive signatures and developing a database containing comparative samples.« less

An analytical model for bio-electronic organic field-effect transistor sensors

NASA Astrophysics Data System (ADS)

Macchia, Eleonora; Giordano, Francesco; Magliulo, Maria; Palazzo, Gerardo; Torsi, Luisa

2013-09-01

A model for the electrical characteristics of Functional-Bio-Interlayer Organic Field-Effect Transistors (FBI-OFETs) electronic sensors is here proposed. Specifically, the output current-voltage characteristics of a streptavidin (SA) embedding FBI-OFET are modeled by means of the analytical equations of an enhancement mode p-channel OFET modified according to an ad hoc designed equivalent circuit that is also independently simulated with pspice. An excellent agreement between the model and the experimental current-voltage output characteristics has been found upon exposure to 5 nM of biotin. A good agreement is also found with the SA OFET parameters graphically extracted from the device transfer I-V curves.

Direct electronic probing of biological complexes formation

NASA Astrophysics Data System (ADS)

Macchia, Eleonora; Magliulo, Maria; Manoli, Kyriaki; Giordano, Francesco; Palazzo, Gerardo; Torsi, Luisa

2014-10-01

Functional bio-interlayer organic field - effect transistors (FBI-OFET), embedding streptavidin, avidin and neutravidin as bio-recognition element, have been studied to probe the electronic properties of protein complexes. The threshold voltage control has been achieved modifying the SiO2 gate diaelectric surface by means of the deposition of an interlayer of bio-recognition elements. A threshold voltage shift with respect to the unmodified dielectric surface toward more negative potential values has been found for the three different proteins, in agreement with their isoelectric points. The relative responses in terms of source - drain current, mobility and threshold voltage upon exposure to biotin of the FBI-OFET devices have been compared for the three bio-recognition elements.

Use of geographic information systems technology to track critical health code violations in retail facilities available to populations of different socioeconomic status and demographics.

PubMed

Darcey, Valerie L; Quinlan, Jennifer J

2011-09-01

Research shows that community socioeconomic status (SES) predicts, based on food service types available, whether a population has access to healthy food. It is not known, however, if a relationship exists between SES and risk for foodborne illness (FBI) at the community level. Geographic information systems (GIS) give researchers the ability to pinpoint health indicators to specific geographic locations and detect resulting environmental gradients. It has been used extensively to characterize the food environment, with respect to access to healthy foods. This research investigated the utility of GIS in determining whether community SES and/or demographics relate to access to safe food, as measured by food service critical health code violations (CHV) as a proxy for risk for FBI. Health inspection records documenting CHV for 10,859 food service facilities collected between 2005 and 2008 in Philadelphia, PA, were accessed. Using an overlay analysis through GIS, CHV were plotted over census tracts of the corresponding area. Census tracts (n = 368) were categorized into quintiles, based on poverty level. Overall, food service facilities in higher poverty areas had a greater number of facilities (with at least one CHV) and had more frequent inspections than facilities in lower poverty areas. The facilities in lower poverty areas, however, had a higher average number of CHV per inspection. Analysis of CHV rates in census tracts with high concentrations of minority populations found Hispanic facilities had more CHV than other demographics, and Hispanic and African American facilities had fewer days between inspections. This research demonstrates the potential for utilization of GIS mapping for tracking risks for FBI. Conversely, it sheds light on the subjective nature of health inspections, and indicates that underlying factors might be affecting inspection frequency and identification of CHV, such that CHV might not be a true proxy for risk for FBI.

Ballistics ordnance gelatine - How different concentrations, temperatures and curing times affect calibration results.

PubMed

Maiden, Nicholas R; Fisk, Wesley; Wachsberger, Christian; Byard, Roger W

2015-08-01

A study was undertaken to determine whether different concentrations of ordnance gelatine, water types, temperatures and curing times would have an effect on projectile penetration of a gelatine tissue surrogate. Both Federal Bureau of Investigation (FBI) and North Atlantic Treaty Organization (NATO) specified gelatines were compared against the FBI calibration standard. 10% w/w and 20% w/w concentrations of gelatine with Bloom numbers of 250 and 285 were prepared and cured at variable temperatures (3-20°C) for 21 hours-3 weeks. Each block was shot on four occasions on the same range using steel calibre 4.5 mm BBs fired from a Daisy(®) air rifle at the required standard velocity of 180 ± 4.5 m/s, to ascertain the mean penetration depth. The results showed no significant difference in mean penetration depth using the three different water types (p > 0.05). Temperature changes and curing times did affect penetration depth. At 10°C, mean penetration depth with 20% gelatine 285 Bloom for the two water types tested was 49.7 ± 1.5 mm after 21 h curing time, whereas the same formulation at 20°C using two different water types was 79.1 ± 2.1 mm after 100 h curing time (p < 0.001). Neither of the NATO 20% concentrations of gelatine at 10°C or a 20% concentration of 285 Bloom gelatine at 10°C met the same calibration standard as the FBI recommended 10% formulation at 4°C. A 20% concentration of 285 Bloom at 20°C met the same calibration/penetration criteria as a 10% concentration of 250 Bloom at 4 °C after 100 h of curing, therefore matching the FBI calibration standard for a soft tissue simulant for wound ballistics research. These results demonstrate significant variability in simulant properties. Failure to standardise ballistic simulants may invalidate experimental results. Copyright © 2015. Published by Elsevier Ltd.

Planning the data transition of a VLDB: a case study

NASA Astrophysics Data System (ADS)

Finken, Shirley J.

1997-02-01

This paper describes the technical and programmatic plans for moving and checking certain data from the IDentification Automated Services (IDAS) system to the new Interstate Identification Index/Federal Bureau of Investigation (III/FBI) Segment database--one of the three components of the Integrated Automated Fingerprint Identification System (IAFIS) being developed by the Federal Bureau of Investigation, Criminal Justice Information Services Division. Transitioning IDAS to III/FBI includes putting the data into an entirely new target database structure (i.e. from IBM VSAM files to ORACLE7 RDBMS tables). Only four IDAS files were transitioned (CCN, CCR, CCA, and CRS), but their total estimated size is at 500 Gb of data. Transitioning of this Very Large Database is planned as two processes.

The multi-species Farley-Buneman instability in the solar chromosphere

DOE Office of Scientific and Technical Information (OSTI.GOV)

Madsen, Chad A.; Dimant, Yakov S.; Oppenheim, Meers M.

2014-03-10

Empirical models of the solar chromosphere show intense electron heating immediately above its temperature minimum. Mechanisms such as resistive dissipation and shock waves appear insufficient to account for the persistence and uniformity of this heating as inferred from both UV lines and continuum measurements. This paper further develops the theory of the Farley-Buneman instability (FBI) which could contribute substantially to this heating. It expands upon the single-ion theory presented by Fontenla by developing a multiple-ion-species approach that better models the diverse, metal-dominated ion plasma of the solar chromosphere. This analysis generates a linear dispersion relationship that predicts the critical electronmore » drift velocity needed to trigger the instability. Using careful estimates of collision frequencies and a one-dimensional, semi-empirical model of the chromosphere, this new theory predicts that the instability may be triggered by velocities as low as 4 km s{sup -1}, well below the neutral acoustic speed. In the Earth's ionosphere, the FBI occurs frequently in situations where the instability trigger speed significantly exceeds the neutral acoustic speed. From this, we expect neutral flows rising from the photosphere to have enough energy to easily create electric fields and electron Hall drifts with sufficient amplitude to make the FBI common in the chromosphere. If so, this process will provide a mechanism to convert neutral flow and turbulence energy into electron thermal energy in the quiet Sun.« less

The Multi-species Farley-Buneman Instability in the Solar Chromosphere

NASA Astrophysics Data System (ADS)

Madsen, Chad A.; Dimant, Yakov S.; Oppenheim, Meers M.; Fontenla, Juan M.

2014-03-01

Empirical models of the solar chromosphere show intense electron heating immediately above its temperature minimum. Mechanisms such as resistive dissipation and shock waves appear insufficient to account for the persistence and uniformity of this heating as inferred from both UV lines and continuum measurements. This paper further develops the theory of the Farley-Buneman instability (FBI) which could contribute substantially to this heating. It expands upon the single-ion theory presented by Fontenla by developing a multiple-ion-species approach that better models the diverse, metal-dominated ion plasma of the solar chromosphere. This analysis generates a linear dispersion relationship that predicts the critical electron drift velocity needed to trigger the instability. Using careful estimates of collision frequencies and a one-dimensional, semi-empirical model of the chromosphere, this new theory predicts that the instability may be triggered by velocities as low as 4 km s-1, well below the neutral acoustic speed. In the Earth's ionosphere, the FBI occurs frequently in situations where the instability trigger speed significantly exceeds the neutral acoustic speed. From this, we expect neutral flows rising from the photosphere to have enough energy to easily create electric fields and electron Hall drifts with sufficient amplitude to make the FBI common in the chromosphere. If so, this process will provide a mechanism to convert neutral flow and turbulence energy into electron thermal energy in the quiet Sun.

Behavioral and activities of daily living inventories in the diagnosis of frontotemporal lobar degeneration and Alzheimer’s disease

PubMed Central

Bahia, Valéria Santoro; da Silva, Mari-Nilva Maia; Viana, Rene; Smid, Jerusa; Damin, Antonio Eduardo; Radanovic, Márcia; Nitrini, Ricardo

2008-01-01

The differential diagnosis between frontotemporal lobar degeneration (FTLD) and Alzheimer’s disease (AD) is often challenging. Objectives To verify the usefulness of behavioral and activities of daily living inventories in the differential diagnosis between FTLD and AD. Methods Caregivers of 12 patients with FTLD (nine with frontotemporal dementia, two with semantic dementia and one with progressive non-fluent aphasia) and of 12 patients with probable AD were interviewed. The Brazilian version of the Frontal Behavioral Inventory (FBI) and Disability Assessment for Dementia (DAD ) were used. Results The mean of the MMSE score was 12.4±10.7for patients with FTLD and 11.9±6.2for patients with AD (p=0.93). Mean scores on the DAD were 33.7±27.7in patients with FTLD and 55.6±29.7in patients with AD (p=0.06), while for the FBI they were 42.6±10.0for FTLD and 16.7±11.7for AD (p<0.01). Conclusions In this study, FBI was found to be a helpful tool for the differential diagnosis between FTLD and AD. Although the DAD was not useful in differential diagnosis in our sample we believe it to be important for measuring the severity of the disease through quantitative and qualitative assessment of functional deficits of the patients. PMID:29213552

Tools for quality control of fingerprint databases

NASA Astrophysics Data System (ADS)

Swann, B. Scott; Libert, John M.; Lepley, Margaret A.

2010-04-01

Integrity of fingerprint data is essential to biometric and forensic applications. Accordingly, the FBI's Criminal Justice Information Services (CJIS) Division has sponsored development of software tools to facilitate quality control functions relative to maintaining its fingerprint data assets inherent to the Integrated Automated Fingerprint Identification System (IAFIS) and Next Generation Identification (NGI). This paper provides an introduction of two such tools. The first FBI-sponsored tool was developed by the National Institute of Standards and Technology (NIST) and examines and detects the spectral signature of the ridge-flow structure characteristic of friction ridge skin. The Spectral Image Validation/Verification (SIVV) utility differentiates fingerprints from non-fingerprints, including blank frames or segmentation failures erroneously included in data; provides a "first look" at image quality; and can identify anomalies in sample rates of scanned images. The SIVV utility might detect errors in individual 10-print fingerprints inaccurately segmented from the flat, multi-finger image acquired by one of the automated collection systems increasing in availability and usage. In such cases, the lost fingerprint can be recovered by re-segmentation from the now compressed multi-finger image record. The second FBI-sponsored tool, CropCoeff was developed by MITRE and thoroughly tested via NIST. CropCoeff enables cropping of the replacement single print directly from the compressed data file, thus avoiding decompression and recompression of images that might degrade fingerprint features necessary for matching.

Closing the Gates.

ERIC Educational Resources Information Center

Chronicle of Higher Education, 2003

2003-01-01

In several sections, explores how the quest for homeland security is changing academe. Discusses the FBI on campus, visa delays, government funding for antiterrorism research, educational programs in counterterrorism, and civil liberties. (EV)

Congress, NRC mull utility access to FBI criminal files

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ultroska, D.

1984-08-01

Experiences at Alabama Power Company and other nuclear utilities have promped a request for institutionalizing security checks of personnel in order to eliminated convicted criminals and drug users. The Nuclear Regulatory Commission (NRC), which could provide FBI criminal history information by submitting fingerprints, does not do so, and would require new legislation to take on that duty. Believing that current malevolent employees can be managed with existing procedures, NRC allows criminal background checks only on prospective employees in order to avoid a negative social impact on personnel. Legislation to transfer criminal histories to nuclear facilities is now pending, and NRCmore » is leaning toward a request for full disclosure, partly because of terrorist threats and partly to save manpower time and costs in reviewing case histories.« less

28 CFR 907.3 - Assessing compliance.

Code of Federal Regulations, 2011 CFR

2011-07-01

... fingerprints to the State repositories and criminal justice and noncriminal justice agencies with direct access... noncriminal justice entities authorized to submit fingerprints directly to the FBI. The reviews may consist of...

28 CFR 907.3 - Assessing compliance.

Code of Federal Regulations, 2014 CFR

2014-07-01

... fingerprints to the State repositories and criminal justice and noncriminal justice agencies with direct access... noncriminal justice entities authorized to submit fingerprints directly to the FBI. The reviews may consist of...

28 CFR 907.3 - Assessing compliance.

Code of Federal Regulations, 2012 CFR

2012-07-01

... fingerprints to the State repositories and criminal justice and noncriminal justice agencies with direct access... noncriminal justice entities authorized to submit fingerprints directly to the FBI. The reviews may consist of...

28 CFR 907.3 - Assessing compliance.

Code of Federal Regulations, 2013 CFR

2013-07-01

... fingerprints to the State repositories and criminal justice and noncriminal justice agencies with direct access... noncriminal justice entities authorized to submit fingerprints directly to the FBI. The reviews may consist of...

28 CFR 907.3 - Assessing compliance.

Code of Federal Regulations, 2010 CFR

2010-07-01

... fingerprints to the State repositories and criminal justice and noncriminal justice agencies with direct access... noncriminal justice entities authorized to submit fingerprints directly to the FBI. The reviews may consist of...

A note on Hardy-Weinberg equilibrium of VNTR data by using the Federal Bureau of Investigation's fixed-bin method

DOE Office of Scientific and Technical Information (OSTI.GOV)

Devlin, B.; Risch, N.

1992-09-01

To fully utilize the information of VNTR data for forensic inference, the probability of observing the matching suspect and evidentiary profile in a reference population is estimated, usually by assuming independence of alleles within and between loci. This assumption has been challenged on the basis of the observation that there is frequently an excess of single-band phenotypes (SBP) in forensic data bases, which could indicate lack of independence. Nevertheless, another explanation is that the excess SBP are artifacts of laboratory methods. In this report the authors examine the excess of SBP for three VNTR loci studied by the FBI (D17S79more » and D2S44, for blacks, and D14S13, for Caucasians). The FBI claims that the excess is due to the effect of null alleles; the null alleles are suspected to be small to be detected. The authors estimate the frequency of null alleles for two loci (D17S79 and D14A13) by comparing, for these loci, the data from the FBI data base and the data from the Lifecodes data base. These comparisons yield information on small fragments because Lifecodes uses the restriction enzyme PstI, which yields larger fragments than does HaeIII, which the FBI uses. For D17S19 in blacks, the authors estimate a null allele frequency of 4.4%, and, for D14S13 in Caucasians, they estimate a frequency of 3.0%. The null-allele frequency for D2S44 in blacks is derived similarly, again being based on analysis of DNA cut with HaeIII and PstI; the estimate of the null-allele frequency for this locus is 1.5%. Using these null-allele frequency estimates and a goodness-of-fit test, the authors show that there is no evidence for deviations from Hardy-Weinberg expectations of genotype probabilities at these loci. 20 refs., 1 fig.« less

Effects of low phosphorus supply on the availability of calcium and phosphorus, and musculoskeletal development of growing dogs of two different breeds.

PubMed

Kiefer-Hecker, B; Kienzle, E; Dobenecker, B

2018-06-01

To investigate the impact of a selective reduction in dietary phosphorus (P) supply on healthy growing dogs, a total of 23 Beagles and 30 Foxhound crossbreds (FBI) were used in a feeding trial between 6 and 24 weeks of age. Sixteen Beagles and 19 FBI were fed with selectively reduced P concentrations (low phosphorus, LP). The remaining puppies received a completely balanced control diet (CON). With these diets, the P supply in the Beagles at the age of 12 weeks added up to 2.5 ± 0.6 (LP) and 9.8 ± 1.4 g P/kg DM (CON), and in the FBI 4.3 ± 0.9 (LP) and 13.0 ± 1.6 g P/kg DM (CON). Therefore, the LP Beagles received an average of 33 ± 11% of the recommended daily allowances (RDA) of P, the LP FBI 41 ± 11%. The calcium (Ca) concentration stayed unaltered and led to a Ca/P ratio above the recommended range of 1.3/1 to 2/1. The apparent digestibility (aD) of phosphorus was reduced in the LP Beagle; otherwise, the aD of both minerals was not affected by the P concentration of the diet. The renal excretion of P was reduced to zero in both LP groups while the renal calcium excretion increased significantly. Several of the puppies from both breeds showed impaired appetite, growth, skin and fur quality, and a few also clinically showed relevant signs of a disturbed musculoskeletal system after the LP feeding. A rapid loss of muscle strength and posture within hours led to severe deviation of the limb axis with hyperflexion of the joints but no radiological aberrations or signs of pain. Immediate transition of affected puppies to a balanced diet with sufficient phosphorus resulted in a complete recovery of the puppies in less than one month. The results demonstrate the importance of an adequate P supply on the healthy development of growing dogs. © 2018 Blackwell Verlag GmbH.

Department of Homeland Security

MedlinePlus

... Release Joint Technical Alerts on Malicious North Korean Cyber Activity Today, DHS and FBI released a pair ... María Provide Feedback to DHS Protect Myself from Cyber Attacks Report Cyber Incidents Prepare My Family for ...

FBI fingerprint identification automation study: AIDS 3 evaluation report. Volume 6: Environmental analysis

NASA Technical Reports Server (NTRS)

Mulhall, B. D. L.

1980-01-01

The results of the analysis of the external environment of the FBI Fingerprint Identification Division are presented. Possible trends in the future environment of the Division that may have an effect on the work load were projected to determine if future work load will lie within the capability range of the proposed new system, AIDS 3. Two working models of the environment were developed, the internal and external model, and from these scenarios the projection of possible future work load volume and mixture was developed. Possible drivers of work load change were identified and assessed for upper and lower bounds of effects. Data used for the study were derived from historical information, analysis of the current situation and from interviews with various agencies who are users of or stakeholders in the present system.

Doe v. Attorney General of the United States.

PubMed

1989-08-25

The Federal Bureau of Investigation stopped referring employees and applicants to the plaintiff physician's clinic upon learning that he had contracted AIDS and Kaposi's sarcoma. The plaintiff sued under the federal Rehabilitation Act, which forbids government funded programs from discriminating against otherwise qualified persons solely on the basis of a handicap. The District Court held that no private cause of action existed against a government agency that purchases services from a plaintiff's employer, because case precedent has ruled against such a cause of action and because Justice Department regulations provide only administrative remedies. The court also ruled that the FBI did not violate the plaintiff's privacy rights, because FBI officials acted with legitimate concern for their affiliates' welfare based on extant knowledge, and had discussed the matter only with the clinic's director and within the Justice Department.

28 CFR 100.19 - Adjustments to agreement estimate.

Code of Federal Regulations, 2010 CFR

2010-07-01

... the FBI when any change affecting the level of reimbursement occurs. (2) Upon such notification, if..., to the best of the carrier's knowledge and belief, the carrier is entitled to the offset in the...

78 FR 69447 - Agency Information Collection Activities; Existing Collection, Comments Requested: Friction Ridge...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-19

... Integrated Automated Fingerprint Identification System (IAFIS) of the FBI. (5) An estimate of the total... approximately 74,793 agencies as respondents at 10 minutes per fingerprint card completed. (6) An estimate of...

76 FR 35022 - Agency Information Collection Activities; Proposed Collection, Comments Requested; Applicant...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-15

... K. Hurst, Management Program Analyst, FBI, CJIS Division, Biometric Services Section (BSS), Support... identification record to review it or to obtain a change, correction, or an update to the record. (5) An estimate...

Collaboration Between Public Health and Law Enforcement: New Paradigms and Partnerships for Bioterrorism Planning and Response

PubMed Central

Cohen, Mitchell L.; Friedman, Cindy R.; Scripp, Robert M.; Watz, Craig G.

2002-01-01

The biological attacks with powders containing Bacillus anthracis sent through the mail during September and October 2001 led to unprecedented public health and law enforcement investigations, which involved thousands of investigators from federal, state, and local agencies. Following recognition of the first cases of anthrax in Florida in early October 2001, investigators from Centers for Disease Control and Prevention (CDC) and the Federal Bureau of Investigation (FBI) were mobilized to assist investigators from state and local public health and law enforcement agencies. Although public health and criminal investigations have been conducted in concert in the past, the response to the anthrax attacks required close collaboration because of the immediate and ongoing threat to public safety. We describe the collaborations between CDC and FBI during the investigation of the 2001 anthrax attacks and highlight the challenges and successes of public health and law enforcement collaborations in general. PMID:12396931

Wavelet/scalar quantization compression standard for fingerprint images

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brislawn, C.M.

1996-06-12

US Federal Bureau of Investigation (FBI) has recently formulated a national standard for digitization and compression of gray-scale fingerprint images. Fingerprints are scanned at a spatial resolution of 500 dots per inch, with 8 bits of gray-scale resolution. The compression algorithm for the resulting digital images is based on adaptive uniform scalar quantization of a discrete wavelet transform subband decomposition (wavelet/scalar quantization method). The FBI standard produces archival-quality images at compression ratios of around 15 to 1 and will allow the current database of paper fingerprint cards to be replaced by digital imagery. The compression standard specifies a class ofmore » potential encoders and a universal decoder with sufficient generality to reconstruct compressed images produced by any compliant encoder, allowing flexibility for future improvements in encoder technology. A compliance testing program is also being implemented to ensure high standards of image quality and interchangeability of data between different implementations.« less

Injury rates and injury risk factors among Federal Bureau of Investigation new agent trainees.

PubMed

Knapik, Joseph J; Grier, Tyson; Spiess, Anita; Swedler, David I; Hauret, Keith G; Graham, Bria; Yoder, James; Jones, Bruce H

2011-12-13

A one-year prospective examination of injury rates and injury risk factors was conducted in Federal Bureau of Investigation (FBI) new agent training. Injury incidents were obtained from medical records and injury compensation forms. Potential injury risk factors were acquired from a lifestyle questionnaire and existing data at the FBI Academy. A total of 426 men and 105 women participated in the project. Thirty-five percent of men and 42% of women experienced one or more injuries during training. The injury incidence rate was 2.5 and 3.2 injuries/1,000 person-days for men and women, respectively (risk ratio (women/men) = 1.3, 95% confidence interval = 0.9-1.7). The activities most commonly associated with injuries (% of total) were defensive tactics training (58%), physical fitness training (20%), physical fitness testing (5%), and firearms training (3%). Among the men, higher injury risk was associated with older age, slower 300-meter sprint time, slower 1.5-mile run time, lower total points on the physical fitness test (PFT), lower self-rated physical activity, lower frequency of aerobic exercise, a prior upper or lower limb injury, and prior foot or knee pain that limited activity. Among the women higher injury risk was associated with slower 300-meter sprint time, slower 1.5-mile run time, lower total points on the PFT, and prior back pain that limited activity. The results of this investigation supported those of a previous retrospective investigation emphasizing that lower fitness and self-reported pain limiting activity were associated with higher injury risk among FBI new agents.

Asymmetry in the Farley-Buneman dispersion relation caused by parallel electric fields

NASA Astrophysics Data System (ADS)

Forsythe, Victoriya V.; Makarevich, Roman A.

2016-11-01

An implicit assumption utilized in studies of E region plasma waves generated by the Farley-Buneman instability (FBI) is that the FBI dispersion relation and its solutions for the growth rate and phase velocity are perfectly symmetric with respect to the reversal of the wave propagation component parallel to the magnetic field. In the present study, a recently derived general dispersion relation that describes fundamental plasma instabilities in the lower ionosphere including FBI is considered and it is demonstrated that the dispersion relation is symmetric only for background electric fields that are perfectly perpendicular to the magnetic field. It is shown that parallel electric fields result in significant differences between the growth rates and phase velocities for propagation of parallel components of opposite signs. These differences are evaluated using numerical solutions of the general dispersion relation and shown to exhibit an approximately linear relationship with the parallel electric field near the E region peak altitude of 110 km. An analytic expression for the differences is also derived from an approximate version of the dispersion relation, with comparisons between numerical and analytic results agreeing near 110 km. It is further demonstrated that parallel electric fields do not change the overall symmetry when the full 3-D wave propagation vector is reversed, with no symmetry seen when either the perpendicular or parallel component is reversed. The present results indicate that moderate-to-strong parallel electric fields of 0.1-1.0 mV/m can result in experimentally measurable differences between the characteristics of plasma waves with parallel propagation components of opposite polarity.

Emigrant psychoanalysts in the USA and the FBI archives.

PubMed

Goggin, James E; Goggin, Eileen Brockman; Hill, Mary

2004-01-01

Interest in the fate of the German psychoanalysts who had to flee Hitler's Germany and find refuge in a new nation, such as the United States, has increased. The "émigré research" shows that several themes recur: (1) the theme of "loss" of one's culture, homeland, language, and family; and (2) the ambivalent welcome these émigrés received in their new country. We describe the political-social-cultural context that existed in the United States during the 1930s, 1940s, and 1950s. Documentary evidence found in the FBI files of three émigré psychoanalysts, Clara Happel, Martin Grotjahn, and Otto Fenichel, are then presented in combination with other source material. This provides a provisional impression of how each of these three individuals experienced their emigration. As such, it gives us elements of a history. The FBI documents suggest that the American atmosphere of political insecurity and fear-based ethnocentric nationalism may have reinforced their old fears of National Socialism, and contributed to their inclination to inhibit or seal off parts of themselves and their personal histories in order to adapt to their new home and become Americanized. They abandoned the rich social, cultural, political tradition that was part of European psychoanalysis. Finally, we look at these elements of a history in order to ask a larger question about the appropriate balance between a liberal democratic government's right to protect itself from internal and external threats on the one hand, or crossover into the blatant invasion of civil rights and due process on the other.

Macroscopic phase separation of superconductivity and ferromagnetism in Sr0.5Ce0.5FBiS2-x Se x revealed by μSR.

PubMed

Nikitin, A M; Grinenko, V; Sarkar, R; Orain, J-C; Salis, M V; Henke, J; Huang, Y K; Klauss, H-H; Amato, A; Visser, A de

2017-12-12

The compound Sr 0.5 Ce 0.5 FBiS 2 belongs to the intensively studied family of layered BiS 2 superconductors. It attracts special attention because superconductivity at T sc  = 2.8 K was found to coexist with local-moment ferromagnetic order with a Curie temperature T C  = 7.5 K. Recently it was reported that upon replacing S by Se T C drops and ferromagnetism becomes of an itinerant nature. At the same time T sc increases and it was argued superconductivity coexists with itinerant ferromagnetism. Here we report a muon spin rotation and relaxation study (μSR) conducted to investigate the coexistence of superconductivity and ferromagnetic order in Sr 0.5 Ce 0.5 FBiS 2-x Se x with x = 0.5 and 1.0. By inspecting the muon asymmetry function we find that both phases do not coexist on the microscopic scale, but occupy different sample volumes. For x = 0.5 and x = 1.0 we find a ferromagnetic volume fraction of ~8 % and ~30 % at T = 0.25 K, well below T C  = 3.4 K and T C  = 3.3 K, respectively. For x = 1.0 (T sc  = 2.9 K) the superconducting phase occupies most (~64 %) of the remaining sample volume, as shown by transverse field experiments that probe the Gaussian damping due to the vortex lattice. We conclude ferromagnetism and superconductivity are macroscopically phase separated.

10 CFR 73.2 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... check includes, at a minimum, a Federal Bureau of Investigation (FBI) criminal history records check (including verification of identity based on fingerprinting), employment history, education, and personal... fingerprinting and criminal history records checks before granting access to Safeguards Information. A background...

42 CFR 136.410 - Who conducts the background investigation and prepares determinations of eligibility for employment?

Code of Federal Regulations, 2010 CFR

2010-10-01

... SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES INDIAN HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN... private firms, or may request that a Federal or State agency conduct investigations. (FBI criminal history...

28 CFR 20.3 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... supervision, and release. The term does not include identification information such as fingerprint records if.... (l) Fingerprint Identification Records System or “FIRS” means the following FBI records: Criminal fingerprints and/or related criminal justice information submitted by authorized agencies having criminal...

28 CFR 20.3 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... supervision, and release. The term does not include identification information such as fingerprint records if.... (l) Fingerprint Identification Records System or “FIRS” means the following FBI records: Criminal fingerprints and/or related criminal justice information submitted by authorized agencies having criminal...

28 CFR 20.3 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... supervision, and release. The term does not include identification information such as fingerprint records if.... (l) Fingerprint Identification Records System or “FIRS” means the following FBI records: Criminal fingerprints and/or related criminal justice information submitted by authorized agencies having criminal...

28 CFR 20.3 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... supervision, and release. The term does not include identification information such as fingerprint records if.... (l) Fingerprint Identification Records System or “FIRS” means the following FBI records: Criminal fingerprints and/or related criminal justice information submitted by authorized agencies having criminal...

28 CFR 20.3 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... supervision, and release. The term does not include identification information such as fingerprint records if.... (l) Fingerprint Identification Records System or “FIRS” means the following FBI records: Criminal fingerprints and/or related criminal justice information submitted by authorized agencies having criminal...

78 FR 6357 - Submission for Renewal: New Information Collection, Fingerprint Chart Standard Form 87 (SF 87)

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-30

..., IPAC and MNU blocks support billing and processing enhancements. The printed ORI number is no longer necessary because SF 87 forms are converted to images and transmitted to the FBI electronically. The Public...

77 FR 36002 - Agency Information Collection Activities: Existing Collection; Comments Requested: Extension of a...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-15

... counts per inmate for a maximum of three convicted offenses per inmate Prior time spent in prison and... parole discharge or parole office FBI identification number Prior military service, date and type of last...

28 CFR 105.27 - Miscellaneous provisions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 105.27 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) CRIMINAL HISTORY BACKGROUND CHECKS... national fingerprint-based criminal history checks of prospective and current private security officers and... history checks of prospective and current private security officers. (b) FBI fees for national check. The...

28 CFR 105.27 - Miscellaneous provisions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 105.27 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) CRIMINAL HISTORY BACKGROUND CHECKS... national fingerprint-based criminal history checks of prospective and current private security officers and... history checks of prospective and current private security officers. (b) FBI fees for national check. The...

28 CFR 105.27 - Miscellaneous provisions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 105.27 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) CRIMINAL HISTORY BACKGROUND CHECKS... national fingerprint-based criminal history checks of prospective and current private security officers and... history checks of prospective and current private security officers. (b) FBI fees for national check. The...

28 CFR 105.27 - Miscellaneous provisions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 105.27 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) CRIMINAL HISTORY BACKGROUND CHECKS... national fingerprint-based criminal history checks of prospective and current private security officers and... history checks of prospective and current private security officers. (b) FBI fees for national check. The...

28 CFR 105.27 - Miscellaneous provisions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 105.27 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) CRIMINAL HISTORY BACKGROUND CHECKS... national fingerprint-based criminal history checks of prospective and current private security officers and... history checks of prospective and current private security officers. (b) FBI fees for national check. The...

45 CFR 2552.31 - Under what circumstances may I follow alternative procedures in conducting a State criminal...

Code of Federal Regulations, 2011 CFR

2011-10-01

... alternative procedures in conducting a State criminal registry check? (a) FBI fingerprint-based check. If you or your designee conduct and document a fingerprint-based criminal history check through the Federal...

45 CFR 2540.206 - Under what circumstances may I follow alternative procedures in conducting a State criminal...

Code of Federal Regulations, 2012 CFR

2012-10-01

... criminal registry check for a covered position? (a) FBI fingerprint-based check. If you conduct and document a fingerprint-based criminal history check through the Federal Bureau of Investigation, you will...

45 CFR 2540.206 - Under what circumstances may I follow alternative procedures in conducting a State criminal...

Code of Federal Regulations, 2010 CFR

2010-10-01

... criminal registry check for a covered position? (a) FBI fingerprint-based check. If you conduct and document a fingerprint-based criminal history check through the Federal Bureau of Investigation, you will...

45 CFR 2551.31 - Under what circumstances may I follow alternative procedures in conducting a State criminal...

Code of Federal Regulations, 2010 CFR

2010-10-01

... alternative procedures in conducting a State criminal registry check? (a) FBI fingerprint-based check. If you or your designee conduct and document a fingerprint-based criminal history check through the Federal...

45 CFR 2552.31 - Under what circumstances may I follow alternative procedures in conducting a State criminal...

Code of Federal Regulations, 2010 CFR

2010-10-01

... alternative procedures in conducting a State criminal registry check? (a) FBI fingerprint-based check. If you or your designee conduct and document a fingerprint-based criminal history check through the Federal...

45 CFR 2552.31 - Under what circumstances may I follow alternative procedures in conducting a State criminal...

Code of Federal Regulations, 2012 CFR

2012-10-01

... alternative procedures in conducting a State criminal registry check? (a) FBI fingerprint-based check. If you or your designee conduct and document a fingerprint-based criminal history check through the Federal...

45 CFR 2551.31 - Under what circumstances may I follow alternative procedures in conducting a State criminal...

Code of Federal Regulations, 2011 CFR

2011-10-01

... alternative procedures in conducting a State criminal registry check? (a) FBI fingerprint-based check. If you or your designee conduct and document a fingerprint-based criminal history check through the Federal...

45 CFR 2551.31 - Under what circumstances may I follow alternative procedures in conducting a State criminal...

Code of Federal Regulations, 2012 CFR

2012-10-01

... alternative procedures in conducting a State criminal registry check? (a) FBI fingerprint-based check. If you or your designee conduct and document a fingerprint-based criminal history check through the Federal...

45 CFR 2540.206 - Under what circumstances may I follow alternative procedures in conducting a State criminal...

Code of Federal Regulations, 2011 CFR

2011-10-01

... criminal registry check for a covered position? (a) FBI fingerprint-based check. If you conduct and document a fingerprint-based criminal history check through the Federal Bureau of Investigation, you will...

28 CFR 17.18 - Prepublication review.

Code of Federal Regulations, 2011 CFR

2011-07-01

... paragraph (j) of this section for FBI personnel, all questions concerning these obligations should be... preparation (e.g., news interview, panel discussion) without violating the provisions of this paragraph. (h.../Information Dissemination Section, Records Management Division. Such individuals shall also submit questions...

28 CFR 17.18 - Prepublication review.

Code of Federal Regulations, 2010 CFR

2010-07-01

... paragraph (j) of this section for FBI personnel, all questions concerning these obligations should be... preparation (e.g., news interview, panel discussion) without violating the provisions of this paragraph. (h.../Information Dissemination Section, Records Management Division. Such individuals shall also submit questions...

28 CFR 100.18 - Audit.

Code of Federal Regulations, 2012 CFR

2012-07-01

... such as disk, tape) or type (e.g., data bases, applications software, data base management software...., date bases, applications software, data base management software, utilities), sufficient to reflect... timeliness of the cost data, the FBI or other representatives of the Government shall have the right to...

28 CFR 100.18 - Audit.

Code of Federal Regulations, 2010 CFR

2010-07-01

... such as disk, tape) or type (e.g., data bases, applications software, data base management software...., date bases, applications software, data base management software, utilities), sufficient to reflect... timeliness of the cost data, the FBI or other representatives of the Government shall have the right to...

28 CFR 100.18 - Audit.

Code of Federal Regulations, 2011 CFR

2011-07-01

... such as disk, tape) or type (e.g., data bases, applications software, data base management software...., date bases, applications software, data base management software, utilities), sufficient to reflect... timeliness of the cost data, the FBI or other representatives of the Government shall have the right to...

28 CFR 100.18 - Audit.

Code of Federal Regulations, 2013 CFR

2013-07-01

... such as disk, tape) or type (e.g., data bases, applications software, data base management software...., date bases, applications software, data base management software, utilities), sufficient to reflect... timeliness of the cost data, the FBI or other representatives of the Government shall have the right to...

28 CFR 100.18 - Audit.

Code of Federal Regulations, 2014 CFR

2014-07-01

... such as disk, tape) or type (e.g., data bases, applications software, data base management software...., date bases, applications software, data base management software, utilities), sufficient to reflect... timeliness of the cost data, the FBI or other representatives of the Government shall have the right to...

Low Dose Irradiation of Fresh and Fresh-Cut Produce

USDA-ARS?s Scientific Manuscript database

Foodborne illness (FBI) outbreaks in the United States associated with contaminated fruits, vegetables, salads, and juices have prompted redoubled efforts to improve agricultural, post-harvest and supply-chain controls that reduce risk. However, the lack of a broadly applicable antimicrobial process...

Profiling Bad Apples.

ERIC Educational Resources Information Center

LaFee, Scott

2000-01-01

Many school administrators want to develop profiling procedures to identify violence-prone students before bullets start flying. Warning signs (chronic depression, anger, abusive home conditions, violent history) are a staring point. Two FBI agents recommend visiting classrooms, identifying troubled kids, and ensuring that they get help. (MLH)

Integrating Drug Intelligence

DTIC Science & Technology

1990-01-01

ther drug organizations as less susceptible to the organized crime approach. The drug organizations, according to the DEA, are more like AMWAY , with...would 47 Shannon, 93. Johnson interview. 33 ! lend itself more readily than an AMWAY to an FBI-style investigation. I The Office of National Drug

77 FR 31017 - Office of Facilities Management and Program Services; Information Collection; Background...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-24

... a Basic National Agency Check Criminal History, GSA Form 176; and 2. Two sets of fingerprints on FBI Fingerprint Cards, for FD-258. This is not a request to collect new information, this is a request to change...

77 FR 63340 - Agency Information Collection Activities; Existing Collection, Comments Requested: Federal...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-16

... DEPARTMENT OF JUSTICE Federal Bureau of Investigation [OMB Number 1110-0026] Agency Information.... The Department of Justice (DOJ), Federal Bureau of Investigation (FBI), Criminal Justice Information..., Management and Program Analyst, Federal Bureau of Investigation, Criminal Justice Information Services (CJIS...

77 FR 62534 - Agency Information Collection Activities; Existing Collection, Comments Requested: Federal...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-15

... DEPARTMENT OF JUSTICE Federal Bureau of Investigation [OMB Number 1110-0026] Agency Information.... The Department of Justice (DOJ), Federal Bureau of Investigation (FBI), Criminal Justice Information..., Management and Program Analyst, Federal Bureau of Investigation, Criminal Justice Information Services (CJIS...

Predicting Family Burden Following Childhood Traumatic Brain Injury: A Cumulative Risk Approach

PubMed Central

Josie, Katherine Leigh; Peterson, Catherine Cant; Burant, Christopher; Drotar, Dennis; Stancin, Terry; Wade, Shari L.; Yeates, Keith; Taylor, H. Gerry

2015-01-01

Objective To examine the utility of a cumulative risk index (CRI) in predicting the family burden of injury (FBI) over time in families of children with traumatic brain injury (TBI). Participants One hundred eight children with severe or moderate TBI and their families participated in the study. Measures The measures used in the study include the Socioeconomic Composite Index, Life Stressors and Social Resources Inventory—Adult Form, Vineland Adaptive Behavior Scales, Child Behavior Checklist, Children’s Depression Inventory, McMaster Family Assessment Device, Brief Symptom Inventory, and Family Burden of Injury Interview. In addition, information on injury-related risk was obtained via medical charts. Methods Participants were assessed immediately, 6, and 12 months postinjury and at a 4-year extended follow-up. Results Risk variables were dichotomized (ie, high- or low-risk) and summed to create a CRI for each child. The CRI predicted the FBI at all assessments, even after accounting for autocorrelations across repeated assessments. Path coefficients between the outcome measures at each time point were significant, as were all path coefficients from the CRI to family burden at each time point. In addition, all fit indices were above the recommended guidelines, and the χ2 statistic indicated a good fit to the data. Conclusions The current study provides initial support for the utility of a CRI (ie, an index of accumulated risk factors) in predicting family outcomes over time for children with TBI. The time period immediately after injury best predicts the future levels of FBI; however, cumulative risk continues to influence the change across successive postinjury assessments. These results suggest that clinical interventions could be proactive or preventive by intervening with identified “at-risk” subgroups immediately following injury. PMID:19033828

Effect of Binary Source Companions on the Microlensing Optical Depth Determination toward the Galactic Bulge Field

NASA Astrophysics Data System (ADS)

Han, Cheongho

2005-11-01

Currently, gravitational microlensing survey experiments toward the Galactic bulge field use two different methods of minimizing the blending effect for the accurate determination of the optical depth τ. One is measuring τ based on clump giant (CG) source stars, and the other is using ``difference image analysis'' (DIA) photometry to measure the unblended source flux variation. Despite the expectation that the two estimates should be the same assuming that blending is properly considered, the estimates based on CG stars systematically fall below the DIA results based on all events with source stars down to the detection limit. Prompted by the gap, we investigate the previously unconsidered effect of companion-associated events on τ determination. Although the image of a companion is blended with that of its primary star and thus not resolved, the event associated with the companion can be detected if the companion flux is highly magnified. Therefore, companions work effectively as source stars to microlensing, and thus the neglect of them in the source star count could result in a wrong τ estimation. By carrying out simulations based on the assumption that companions follow the same luminosity function as primary stars, we estimate that the contribution of the companion-associated events to the total event rate is ~5fbi% for current surveys and can reach up to ~6fbi% for future surveys monitoring fainter stars, where fbi is the binary frequency. Therefore, we conclude that the companion-associated events comprise a nonnegligible fraction of all events. However, their contribution to the optical depth is not large enough to explain the systematic difference between the optical depth estimates based on the two different methods.

Frontal lobe function and behavioral changes in amyotrophic lateral sclerosis: a study from Southwest China.

PubMed

Wei, QianQian; Chen, XuePing; Zheng, ZhenZhen; Huang, Rui; Guo, XiaoYan; Cao, Bei; Zhao, Bi; Shang, Hui-Fang

2014-12-01

Despite growing interest, the frequency and characteristics of frontal lobe functional and behavioral deficits in Chinese people with amyotrophic lateral sclerosis (ALS), as well as their impact on the survival of ALS patients, remain unknown. The Chinese version of the frontal assessment battery (FAB) and frontal behavioral inventory (FBI) were used to evaluate 126 sporadic ALS patients and 50 healthy controls. The prevalence of frontal lobe dysfunction was 32.5%. The most notable impairment domain of the FAB was lexical fluency (30.7%). The binary logistic regression model revealed that an onset age older than 45 years (OR 5.976, P = 0.002) and a lower educational level (OR 0.858, P = 0.002) were potential determinants of an abnormal FAB. Based on the FBI score, 46.0% of patients showed varied degrees of frontal behavioral changes. The most common impaired neurobehavioral domains were irritability (25.4%), logopenia (20.6%) and apathy (19.0%). The binary logistic regression model revealed that the ALS Functional Rating Scale-Revised scale score (OR 0.127, P = 0.001) was a potential determinant of an abnormal FBI. Frontal functional impairment and the severity of frontal behavioral changes were not associated with the survival status or the progression of ALS by the cox proportional hazard model and multivariate regression analyses, respectively. Frontal lobe dysfunction and frontal behavioral changes are common in Chinese ALS patients. Frontal lobe dysfunction may be related to the onset age and educational level. The severity of frontal behavioral changes may be associated with the ALSFRS-R. However, the frontal functional impairment and the frontal behavioral changes do not worsen the progression or survival of ALS.

Identifying bvFTD Within the Wide Spectrum of Late Onset Frontal Lobe Syndrome: A Clinical Approach.

PubMed

Krudop, Welmoed A; Kerssens, Cora J; Dols, Annemiek; Prins, Niels D; Möller, Christiane; Schouws, Sigfried; van der Flier, Wiesje M; Scheltens, Philip; Sikkes, Sietske; Stek, Max L; Pijnenburg, Yolande A L

2015-10-01

The behavioral variant of frontotemporal dementia (bvFTD) can be difficult to diagnose because of the extensive differential diagnosis, including many other diseases presenting with a frontal lobe syndrome. We aimed to identify the diagnostic spectrum causing a late onset frontal lobe syndrome and examine the quality of commonly used instruments to distinguish between bvFTD and non-bvFTD patients, within this syndrome. A total of 137 patients fulfilling the criteria of late onset frontal lobe syndrome, aged 45 to 75 years, were included in a prospective observational study. Diagnoses were made after clinical and neuropsychological examination, and neuroimaging and cerebral spinal fluid results were taken into account. Baseline characteristics and the scores on the Mini-Mental State Exam (MMSE), frontal assessment battery (FAB), Frontal Behavioral Inventory (FBI), and Stereotypy Rating Inventory (SRI) were compared between the bvFTD and the non-bvFTD group. Fifty-five (40%) of the patients received a bvFTD diagnosis (33% probable and 7% possible bvFTD). Fifty-one patients (37%) had a psychiatric disorder, including 20 with major depressive disorder. Thirty-one patients received an alternative neurological, including neurodegenerative, diagnosis. MMSE and FAB scores were unspecific for a particular diagnosis. A score above 12 on the positive FBI subscale or a score above 5 on the SRI were indicative of a bvFTD diagnosis. A broad spectrum of both neurological and psychiatric disorders underlies late onset frontal lobe syndrome, of which bvFTD was the most prevalent diagnosis in our cohort. The commonly used MMSE and the FAB could not successfully distinguish between bvFTD and non-bvFTD, but this could be achieved with the more specific FBI and SRI. Copyright © 2015 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.

Injury rates and injury risk factors among federal bureau of investigation new agent trainees

PubMed Central

2011-01-01

Background A one-year prospective examination of injury rates and injury risk factors was conducted in Federal Bureau of Investigation (FBI) new agent training. Methods Injury incidents were obtained from medical records and injury compensation forms. Potential injury risk factors were acquired from a lifestyle questionnaire and existing data at the FBI Academy. Results A total of 426 men and 105 women participated in the project. Thirty-five percent of men and 42% of women experienced one or more injuries during training. The injury incidence rate was 2.5 and 3.2 injuries/1,000 person-days for men and women, respectively (risk ratio (women/men) = 1.3, 95% confidence interval = 0.9-1.7). The activities most commonly associated with injuries (% of total) were defensive tactics training (58%), physical fitness training (20%), physical fitness testing (5%), and firearms training (3%). Among the men, higher injury risk was associated with older age, slower 300-meter sprint time, slower 1.5-mile run time, lower total points on the physical fitness test (PFT), lower self-rated physical activity, lower frequency of aerobic exercise, a prior upper or lower limb injury, and prior foot or knee pain that limited activity. Among the women higher injury risk was associated with slower 300-meter sprint time, slower 1.5-mile run time, lower total points on the PFT, and prior back pain that limited activity. Conclusion The results of this investigation supported those of a previous retrospective investigation emphasizing that lower fitness and self-reported pain limiting activity were associated with higher injury risk among FBI new agents. PMID:22166096

The comparison of proportional hazards and accelerated failure time models in analyzing the first birth interval survival data

NASA Astrophysics Data System (ADS)

Faruk, Alfensi

2018-03-01

Survival analysis is a branch of statistics, which is focussed on the analysis of time- to-event data. In multivariate survival analysis, the proportional hazards (PH) is the most popular model in order to analyze the effects of several covariates on the survival time. However, the assumption of constant hazards in PH model is not always satisfied by the data. The violation of the PH assumption leads to the misinterpretation of the estimation results and decreasing the power of the related statistical tests. On the other hand, the accelerated failure time (AFT) models do not assume the constant hazards in the survival data as in PH model. The AFT models, moreover, can be used as the alternative to PH model if the constant hazards assumption is violated. The objective of this research was to compare the performance of PH model and the AFT models in analyzing the significant factors affecting the first birth interval (FBI) data in Indonesia. In this work, the discussion was limited to three AFT models which were based on Weibull, exponential, and log-normal distribution. The analysis by using graphical approach and a statistical test showed that the non-proportional hazards exist in the FBI data set. Based on the Akaike information criterion (AIC), the log-normal AFT model was the most appropriate model among the other considered models. Results of the best fitted model (log-normal AFT model) showed that the covariates such as women’s educational level, husband’s educational level, contraceptive knowledge, access to mass media, wealth index, and employment status were among factors affecting the FBI in Indonesia.

32 CFR 86.1 - Purpose.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 1 2014-07-01 2014-07-01 false Purpose. 86.1 Section 86.1 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN CRIMINAL HISTORY... Bureau of Investigation (FBI) fingerprint check and State Criminal History Repositories (SCHR) checks of...

32 CFR 86.1 - Purpose.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 1 2011-07-01 2011-07-01 false Purpose. 86.1 Section 86.1 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN CRIMINAL HISTORY... Bureau of Investigation (FBI) fingerprint check and State Criminal History Repositories (SCHR) checks of...

32 CFR 86.1 - Purpose.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 1 2013-07-01 2013-07-01 false Purpose. 86.1 Section 86.1 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN CRIMINAL HISTORY... Bureau of Investigation (FBI) fingerprint check and State Criminal History Repositories (SCHR) checks of...

32 CFR 154.9 - Authorized personnel security investigative agencies.

Code of Federal Regulations, 2013 CFR

2013-07-01

... agencies. 154.9 Section 154.9 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE SECURITY DEPARTMENT OF DEFENSE PERSONNEL SECURITY PROGRAM REGULATION Policies § 154.9 Authorized personnel... Conduct of Defense Department Counterintelligence Activities in Conjunction with the FBI. Whenever...

32 CFR 154.9 - Authorized personnel security investigative agencies.

Code of Federal Regulations, 2014 CFR

2014-07-01

... agencies. 154.9 Section 154.9 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE SECURITY DEPARTMENT OF DEFENSE PERSONNEL SECURITY PROGRAM REGULATION Policies § 154.9 Authorized personnel... Conduct of Defense Department Counterintelligence Activities in Conjunction with the FBI. Whenever...

32 CFR 154.9 - Authorized personnel security investigative agencies.

Code of Federal Regulations, 2012 CFR

2012-07-01

... agencies. 154.9 Section 154.9 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE SECURITY DEPARTMENT OF DEFENSE PERSONNEL SECURITY PROGRAM REGULATION Policies § 154.9 Authorized personnel... Conduct of Defense Department Counterintelligence Activities in Conjunction with the FBI. Whenever...

32 CFR 86.1 - Purpose.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 1 2012-07-01 2012-07-01 false Purpose. 86.1 Section 86.1 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN CRIMINAL HISTORY... Bureau of Investigation (FBI) fingerprint check and State Criminal History Repositories (SCHR) checks of...

32 CFR 86.1 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 1 2010-07-01 2010-07-01 false Purpose. 86.1 Section 86.1 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN CRIMINAL HISTORY... Bureau of Investigation (FBI) fingerprint check and State Criminal History Repositories (SCHR) checks of...

32 CFR 154.9 - Authorized personnel security investigative agencies.

Code of Federal Regulations, 2011 CFR

2011-07-01

... agencies. 154.9 Section 154.9 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE SECURITY DEPARTMENT OF DEFENSE PERSONNEL SECURITY PROGRAM REGULATION Policies § 154.9 Authorized personnel... Conduct of Defense Department Counterintelligence Activities in Conjunction with the FBI. Whenever...

28 CFR 907.2 - Applicability.

Code of Federal Regulations, 2012 CFR

2012-07-01

... FOR COMPLIANT CONDUCT AND RESPONSIBLE USE OF THE INTERSTATE IDENTIFICATION INDEX (III) SYSTEM FOR NONCRIMINAL JUSTICE PURPOSES § 907.2 Applicability. This rule applies to III System access for noncriminal... by means of the System for such purposes. The rule establishes procedures for ensuring that the FBI's...

28 CFR 907.2 - Applicability.

Code of Federal Regulations, 2014 CFR

2014-07-01

... FOR COMPLIANT CONDUCT AND RESPONSIBLE USE OF THE INTERSTATE IDENTIFICATION INDEX (III) SYSTEM FOR NONCRIMINAL JUSTICE PURPOSES § 907.2 Applicability. This rule applies to III System access for noncriminal... by means of the System for such purposes. The rule establishes procedures for ensuring that the FBI's...

28 CFR 907.2 - Applicability.

Code of Federal Regulations, 2011 CFR

2011-07-01

... FOR COMPLIANT CONDUCT AND RESPONSIBLE USE OF THE INTERSTATE IDENTIFICATION INDEX (III) SYSTEM FOR NONCRIMINAL JUSTICE PURPOSES § 907.2 Applicability. This rule applies to III System access for noncriminal... by means of the System for such purposes. The rule establishes procedures for ensuring that the FBI's...

28 CFR 907.2 - Applicability.

Code of Federal Regulations, 2010 CFR

2010-07-01

... FOR COMPLIANT CONDUCT AND RESPONSIBLE USE OF THE INTERSTATE IDENTIFICATION INDEX (III) SYSTEM FOR NONCRIMINAL JUSTICE PURPOSES § 907.2 Applicability. This rule applies to III System access for noncriminal... by means of the System for such purposes. The rule establishes procedures for ensuring that the FBI's...

28 CFR 907.2 - Applicability.

Code of Federal Regulations, 2013 CFR

2013-07-01

... FOR COMPLIANT CONDUCT AND RESPONSIBLE USE OF THE INTERSTATE IDENTIFICATION INDEX (III) SYSTEM FOR NONCRIMINAL JUSTICE PURPOSES § 907.2 Applicability. This rule applies to III System access for noncriminal... by means of the System for such purposes. The rule establishes procedures for ensuring that the FBI's...

32 CFR 154.9 - Authorized personnel security investigative agencies.

Code of Federal Regulations, 2010 CFR

2010-07-01

... agencies. 154.9 Section 154.9 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE SECURITY DEPARTMENT OF DEFENSE PERSONNEL SECURITY PROGRAM REGULATION Policies § 154.9 Authorized personnel... Conduct of Defense Department Counterintelligence Activities in Conjunction with the FBI. Whenever...

28 CFR 27.5 - Review.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Review. 27.5 Section 27.5 Judicial Administration DEPARTMENT OF JUSTICE WHISTLEBLOWER PROTECTION FOR FEDERAL BUREAU OF INVESTIGATION EMPLOYEES Investigating Reprisal Allegations and Ordering Corrective Action § 27.5 Review. The Complainant or the FBI may...

28 CFR 27.5 - Review.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Review. 27.5 Section 27.5 Judicial Administration DEPARTMENT OF JUSTICE WHISTLEBLOWER PROTECTION FOR FEDERAL BUREAU OF INVESTIGATION EMPLOYEES Investigating Reprisal Allegations and Ordering Corrective Action § 27.5 Review. The Complainant or the FBI may...

28 CFR 27.5 - Review.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Review. 27.5 Section 27.5 Judicial Administration DEPARTMENT OF JUSTICE WHISTLEBLOWER PROTECTION FOR FEDERAL BUREAU OF INVESTIGATION EMPLOYEES Investigating Reprisal Allegations and Ordering Corrective Action § 27.5 Review. The Complainant or the FBI may...

The USA PATRIOT Act.

ERIC Educational Resources Information Center

Minow, Mary; Coyle, Karen; Kaufman, Paula

2002-01-01

Explains the USA PATRIOT (Uniting and Strengthening America by Providing Appropriate Tools Required to Intercept and Obstruct Terrorism) Act, passed after the September 11 terrorist attacks, and its implications for libraries and patron records. Considers past dealings with the FBI; court orders; search warrants; wiretaps; and subpoenas. Includes:…

28 CFR 27.5 - Review.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Review. 27.5 Section 27.5 Judicial Administration DEPARTMENT OF JUSTICE WHISTLEBLOWER PROTECTION FOR FEDERAL BUREAU OF INVESTIGATION EMPLOYEES Investigating Reprisal Allegations and Ordering Corrective Action § 27.5 Review. The Complainant or the FBI may...

75 FR 18751 - FBI Criminal Justice Information Services Division User Fees

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-13

... Standards (SFFAS-4): Managerial Cost Accounting Concepts and Standards for the Federal Government; and other relevant financial management directives, BearingPoint developed a cost accounting methodology and related... management process that provides information about the relationships between inputs (costs) and outputs...

28 CFR 25.8 - System safeguards.

Code of Federal Regulations, 2012 CFR

2012-07-01

... justice agency computer site must have adequate physical security to protect against any unauthorized... Index is stored electronically for use in an FBI computer environment. The NICS central computer will... authorized personnel who have identified themselves and their need for access to a system security officer...

28 CFR 25.8 - System safeguards.

Code of Federal Regulations, 2010 CFR

2010-07-01

... justice agency computer site must have adequate physical security to protect against any unauthorized... Index is stored electronically for use in an FBI computer environment. The NICS central computer will... authorized personnel who have identified themselves and their need for access to a system security officer...

28 CFR 25.8 - System safeguards.

Code of Federal Regulations, 2013 CFR

2013-07-01

... justice agency computer site must have adequate physical security to protect against any unauthorized... Index is stored electronically for use in an FBI computer environment. The NICS central computer will... authorized personnel who have identified themselves and their need for access to a system security officer...

28 CFR 25.8 - System safeguards.

Code of Federal Regulations, 2011 CFR

2011-07-01

... justice agency computer site must have adequate physical security to protect against any unauthorized... Index is stored electronically for use in an FBI computer environment. The NICS central computer will... authorized personnel who have identified themselves and their need for access to a system security officer...

28 CFR 25.8 - System safeguards.

Code of Federal Regulations, 2014 CFR

2014-07-01

... justice agency computer site must have adequate physical security to protect against any unauthorized... Index is stored electronically for use in an FBI computer environment. The NICS central computer will... authorized personnel who have identified themselves and their need for access to a system security officer...

6 CFR 37.45 - Background checks for covered employees.

Code of Federal Regulations, 2012 CFR

2012-01-01

..., the validation of references from prior employment, a name-based and fingerprint-based criminal.... States must conduct a name-based and fingerprint-based criminal history records check (CHRC) using, at a minimum, the FBI's National Crime Information Center (NCIC) and the Integrated Automated Fingerprint...

6 CFR 37.45 - Background checks for covered employees.

Code of Federal Regulations, 2010 CFR

2010-01-01

..., the validation of references from prior employment, a name-based and fingerprint-based criminal.... States must conduct a name-based and fingerprint-based criminal history records check (CHRC) using, at a minimum, the FBI's National Crime Information Center (NCIC) and the Integrated Automated Fingerprint...

6 CFR 37.45 - Background checks for covered employees.

Code of Federal Regulations, 2013 CFR

2013-01-01

..., the validation of references from prior employment, a name-based and fingerprint-based criminal.... States must conduct a name-based and fingerprint-based criminal history records check (CHRC) using, at a minimum, the FBI's National Crime Information Center (NCIC) and the Integrated Automated Fingerprint...

6 CFR 37.45 - Background checks for covered employees.

Code of Federal Regulations, 2014 CFR

2014-01-01

..., the validation of references from prior employment, a name-based and fingerprint-based criminal.... States must conduct a name-based and fingerprint-based criminal history records check (CHRC) using, at a minimum, the FBI's National Crime Information Center (NCIC) and the Integrated Automated Fingerprint...

49 CFR 1572.400 - Scope and definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Bureau of Investigation (FBI) to process fingerprint records. Information Collection Fee means the fee required, in this part, for the cost of collecting and transmitting fingerprints and other applicant... agent means an entity approved by TSA to collect and transmit fingerprints and applicant information, in...

49 CFR 1572.400 - Scope and definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Bureau of Investigation (FBI) to process fingerprint records. Information Collection Fee means the fee required, in this part, for the cost of collecting and transmitting fingerprints and other applicant... agent means an entity approved by TSA to collect and transmit fingerprints and applicant information, in...

75 FR 9435 - Agency Information Collection Activities: Existing collection, Comments Requested

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-02

... collection for renewal. Three Fingerprint Cards: Arrest and Institution; Applicant; Personal Identification...-0046. (2) The title of the form/collection: Three Fingerprint Cards: Arrest and Institution; Applicant... Integrated Automated Fingerprint Identification System (IAFIS) of the FBI. (5) An estimate of the total...

49 CFR 1572.400 - Scope and definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Bureau of Investigation (FBI) to process fingerprint records. Information Collection Fee means the fee required, in this part, for the cost of collecting and transmitting fingerprints and other applicant... agent means an entity approved by TSA to collect and transmit fingerprints and applicant information, in...

49 CFR 1572.400 - Scope and definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Bureau of Investigation (FBI) to process fingerprint records. Information Collection Fee means the fee required, in this part, for the cost of collecting and transmitting fingerprints and other applicant... agent means an entity approved by TSA to collect and transmit fingerprints and applicant information, in...

6 CFR 37.45 - Background checks for covered employees.

Code of Federal Regulations, 2011 CFR

2011-01-01

..., the validation of references from prior employment, a name-based and fingerprint-based criminal.... States must conduct a name-based and fingerprint-based criminal history records check (CHRC) using, at a minimum, the FBI's National Crime Information Center (NCIC) and the Integrated Automated Fingerprint...

49 CFR 1572.400 - Scope and definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Bureau of Investigation (FBI) to process fingerprint records. Information Collection Fee means the fee required, in this part, for the cost of collecting and transmitting fingerprints and other applicant... agent means an entity approved by TSA to collect and transmit fingerprints and applicant information, in...

78 FR 56940 - Agency Information Collection Activities; Existing Collection-Reinstatement, Comments Requested...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-16

... DEPARTMENT OF JUSTICE Federal Bureau of Investigation [OMB Number 1110-0046] Agency Information... Palm Print ACTION: 60-day Notice. The Department of Justice, Federal Bureau of Investigation (FBI..., Supervisory Management and Program Analyst, Federal Bureau of Investigation, Criminal Justice Information...

Comparing Electronic News Media Reports of Potential Bioterrorism-Related Incidents Involving Unknown White Powder to Reports Received by the United States Centers for Disease Control and Prevention and the Federal Bureau of Investigation: USA, 2009–2011

PubMed Central

Fajardo, Geroncio C.; Posid, Joseph; Papagiotas, Stephen; Lowe, Luis

2015-01-01

There have been periodic electronic news media reports of potential bioterrorism-related incidents involving unknown substances (often referred to as “white powder”) since the 2001 intentional dissemination of Bacillus anthracis through the US Postal System. This study reviewed the number of unknown “white powder” incidents reported online by the electronic news media and compared them with unknown “white powder” incidents reported to the US Centers for Disease Control and Prevention (CDC) and the US Federal Bureau of Investigation (FBI) during a two-year period from June 1, 2009 and May 31, 2011. Results identified 297 electronic news media reports, 538 CDC reports, and 384 FBI reports of unknown “white powder.” This study showed different unknown “white powder” incidents captured by each of the three sources. However, the authors could not determine the public health implications of this discordance. PMID:25420771

Delayed coupling to feedback inhibition during a critical period for the integration of adult-born granule cells

PubMed Central

Temprana, Silvio G.; Mongiat, Lucas A.; Yang, Sung M.; Trinchero, Mariela F.; Alvarez, Diego D.; Kropff, Emilio; Giacomini, Damiana; Beltramone, Natalia; Lanuza, Guillermo M.; Schinder, Alejandro F.

2014-01-01

SUMMARY Developing granule cells (GCs) of the adult dentate gyrus undergo a critical period of enhanced activity and synaptic plasticity before becoming mature. The impact of developing GCs on the activity of preexisting dentate circuits remains unknown. Here we combine optogenetics, acute slice electrophysiology, and in vivo chemogenetics to activate GCs at different stages of maturation to study the recruitment of local target networks. We show that immature (four-week-old) GCs can efficiently drive distal CA3 targets, but poorly activate proximal interneurons responsible for feedback inhibition (FBI). As new GCs transition towards maturity, they reliably recruit GABAergic feedback loops that restrict spiking of neighbor GCs, a mechanism that would promote sparse coding. Such inhibitory loop impinges only weakly in new cohorts of young GCs. A computational model reveals that the delayed coupling of new GCs to FBI could be crucial to achieve a fine-grain representation of novel inputs in the dentate gyrus. PMID:25533485

Delayed coupling to feedback inhibition during a critical period for the integration of adult-born granule cells.

PubMed

Temprana, Silvio G; Mongiat, Lucas A; Yang, Sung M; Trinchero, Mariela F; Alvarez, Diego D; Kropff, Emilio; Giacomini, Damiana; Beltramone, Natalia; Lanuza, Guillermo M; Schinder, Alejandro F

2015-01-07

Developing granule cells (GCs) of the adult dentate gyrus undergo a critical period of enhanced activity and synaptic plasticity before becoming mature. The impact of developing GCs on the activity of preexisting dentate circuits remains unknown. Here we combine optogenetics, acute slice electrophysiology, and in vivo chemogenetics to activate GCs at different stages of maturation to study the recruitment of local target networks. We show that immature (4-week-old) GCs can efficiently drive distal CA3 targets but poorly activate proximal interneurons responsible for feedback inhibition (FBI). As new GCs transition toward maturity, they reliably recruit GABAergic feedback loops that restrict spiking of neighbor GCs, a mechanism that would promote sparse coding. Such inhibitory loop impinges only weakly in new cohorts of young GCs. A computational model reveals that the delayed coupling of new GCs to FBI could be crucial to achieve a fine-grain representation of novel inputs in the dentate gyrus. Copyright © 2015 Elsevier Inc. All rights reserved.

75 FR 24796 - FBI Records Management Division National Name Check Program Section User Fees

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-06

... with generally accepted accounting principles, also include such expenses as capital investment... by RMD. Referencing OMB Circular A-25; the Statement of Federal Financial Accounting Standards (SFFAS... financial management directives, Grant Thornton developed a cost accounting methodology and related cost...

28 CFR 25.3 - System information.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 28 Judicial Administration 1 2013-07-01 2013-07-01 false System information. 25.3 Section 25.3 Judicial Administration DEPARTMENT OF JUSTICE DEPARTMENT OF JUSTICE INFORMATION SYSTEMS The National Instant Criminal Background Check System § 25.3 System information. (a) There is established at the FBI a...

28 CFR 8.1 - Definition.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Definition. 8.1 Section 8.1 Judicial Administration DEPARTMENT OF JUSTICE FBI FORFEITURE AUTHORITY FOR CERTAIN STATUTES § 8.1 Definition. For the purpose of this part, the term statutes shall include the following statutes unless otherwise noted in...

28 CFR 25.3 - System information.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 28 Judicial Administration 1 2011-07-01 2011-07-01 false System information. 25.3 Section 25.3 Judicial Administration DEPARTMENT OF JUSTICE DEPARTMENT OF JUSTICE INFORMATION SYSTEMS The National Instant Criminal Background Check System § 25.3 System information. (a) There is established at the FBI a...

28 CFR 8.1 - Definition.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Definition. 8.1 Section 8.1 Judicial Administration DEPARTMENT OF JUSTICE FBI FORFEITURE AUTHORITY FOR CERTAIN STATUTES § 8.1 Definition. For the purpose of this part, the term statutes shall include the following statutes unless otherwise noted in...

28 CFR 25.3 - System information.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 28 Judicial Administration 1 2014-07-01 2014-07-01 false System information. 25.3 Section 25.3 Judicial Administration DEPARTMENT OF JUSTICE DEPARTMENT OF JUSTICE INFORMATION SYSTEMS The National Instant Criminal Background Check System § 25.3 System information. (a) There is established at the FBI a...

28 CFR 8.1 - Definition.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Definition. 8.1 Section 8.1 Judicial Administration DEPARTMENT OF JUSTICE FBI FORFEITURE AUTHORITY FOR CERTAIN STATUTES § 8.1 Definition. For the purpose of this part, the term statutes shall include the following statutes unless otherwise noted in...

28 CFR 25.3 - System information.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 28 Judicial Administration 1 2012-07-01 2012-07-01 false System information. 25.3 Section 25.3 Judicial Administration DEPARTMENT OF JUSTICE DEPARTMENT OF JUSTICE INFORMATION SYSTEMS The National Instant Criminal Background Check System § 25.3 System information. (a) There is established at the FBI a...

28 CFR 8.6 - Quick-release authority.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Quick-release authority. 8.6 Section 8.6 Judicial Administration DEPARTMENT OF JUSTICE FBI FORFEITURE AUTHORITY FOR CERTAIN STATUTES § 8.6 Quick-release authority. Where the forfeiture proceedings are administrative, the Special Agent in Charge, prior...

28 CFR 8.6 - Quick-release authority.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Quick-release authority. 8.6 Section 8.6 Judicial Administration DEPARTMENT OF JUSTICE FBI FORFEITURE AUTHORITY FOR CERTAIN STATUTES § 8.6 Quick-release authority. Where the forfeiture proceedings are administrative, the Special Agent in Charge, prior...

28 CFR 100.20 - Confidentiality of trade secrets/proprietary information.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Confidentiality of trade secrets/proprietary information. 100.20 Section 100.20 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) COST... trade secrets/proprietary information. With respect to any information provided to the FBI under this...

28 CFR 100.20 - Confidentiality of trade secrets/proprietary information.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Confidentiality of trade secrets/proprietary information. 100.20 Section 100.20 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) COST... trade secrets/proprietary information. With respect to any information provided to the FBI under this...

28 CFR 100.20 - Confidentiality of trade secrets/proprietary information.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Confidentiality of trade secrets/proprietary information. 100.20 Section 100.20 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) COST... trade secrets/proprietary information. With respect to any information provided to the FBI under this...

28 CFR 100.20 - Confidentiality of trade secrets/proprietary information.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Confidentiality of trade secrets/proprietary information. 100.20 Section 100.20 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) COST... trade secrets/proprietary information. With respect to any information provided to the FBI under this...

28 CFR 100.20 - Confidentiality of trade secrets/proprietary information.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Confidentiality of trade secrets/proprietary information. 100.20 Section 100.20 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) COST... trade secrets/proprietary information. With respect to any information provided to the FBI under this...

28 CFR 25.3 - System information.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 1 2010-07-01 2010-07-01 false System information. 25.3 Section 25.3 Judicial Administration DEPARTMENT OF JUSTICE DEPARTMENT OF JUSTICE INFORMATION SYSTEMS The National Instant Criminal Background Check System § 25.3 System information. (a) There is established at the FBI a...

75 FR 18887 - FBI Criminal Justice Information Services Division User Fees

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-13

.... SUMMARY: This notice establishes the user fee schedule for fingerprint- based and name-based criminal... fingerprint-based and other identification services as authorized by federal law. These fees apply to federal, state and any other authorized entities requesting fingerprint identification records and name checks...

The FBI Takes Aim at AIM

ERIC Educational Resources Information Center

Kanter, Elliot

1977-01-01

The events and revelations before and since the arrest of Paul Skyhorse and Richard Mohawk (two American Indian Movement organizers charged with the 1974 murder of a taxi driver at AIM Camp 13) lead to the inevitable conclusion that these men are victims of a frame-up. (Author/JC)

28 CFR 27.5 - Review.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Review. 27.5 Section 27.5 Judicial... Investigating Reprisal Allegations and Ordering Corrective Action § 27.5 Review. The Complainant or the FBI may..., review by the Deputy Attorney General of that determination or order. The Deputy Attorney General shall...

78 FR 41431 - Licensee Identified in Attachment 1 and All Other Persons Who Seek or Obtain Access to Safeguards...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-10

... Fingerprinting and Criminal History Records Check Requirements for Access To Safeguards Information (Effective... Bureau of Investigation (FBI) identification and criminal history records check are required of any... ``fingerprinting relief'' rule. Individuals relieved from fingerprinting and criminal history records checks under...

48 CFR 2452.239-70 - Access to HUD systems.

Code of Federal Regulations, 2014 CFR

2014-10-01

.... 2452.239-70 Section 2452.239-70 Federal Acquisition Regulations System DEPARTMENT OF HOUSING AND URBAN... secret in the interest of national defense or foreign policy. System means an interconnected set of... investigation (NACI or other OPM-required or approved investigation), including an FBI National Criminal History...

Argentina: Background and U.S. Relations

DTIC Science & Technology

2008-11-05

Comercio Internacional, Y Culto, Comunicado de la Cancillería Argentina, September 11, 2008. 43 A. Rebossio, "Fernández Acusa al FBI de Desestablizar...Argentina," El País (Madrid), September 13, 2008. 44 “Argentina Slams Witness in Cash Suitcase Scandal,” Associated Press Newswires, November 4, 2008

Federal Law Enforcement in Bi-National Perspective: The United States FBI and the Mexican PFM

DTIC Science & Technology

2014-09-01

de Ciencias Penales INCLE International Narcotics Control and Law Enforcement IT information technology LISSSTE Ley del Instituto de Seguridad y...Instituto Nacional de Ciencias Penales—INACIPE).195 However, if the video on Youtube.com is an indication of the seriousness with which ministerial

A Safer Campus?

ERIC Educational Resources Information Center

Violino, Bob

2010-01-01

The FBI, in partnership with the U.S. Department of Education and the U.S. Secret Service, recently released a report on violent attacks on college campuses that details ongoing security concerns at U.S. institutions of higher learning, including the nation's 1,173 community colleges. Researchers say the goal of the report, "Campus Attacks:…

National Marrow Donor Program

DTIC Science & Technology

2010-11-05

from power or Internet outages to severe weather. • Received 50 mobile broadband air cards at minimal cost to the organization and ONR to allow for...CLlA CME CMF COG CREG CSS CT CTA DC DHHS-ASPR DIY DKMS DMSO DoD DNA DIR EBMT EM EMDIS ENS ERSI FBI QUARTER PROGRESS REPORT

28 CFR 8.9 - Disposition of forfeited property.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Disposition of forfeited property. 8.9 Section 8.9 Judicial Administration DEPARTMENT OF JUSTICE FBI FORFEITURE AUTHORITY FOR CERTAIN STATUTES § 8.9 Disposition of forfeited property. (a) If the laws of a state in which an article of forfeited...

A Distance Learning Case Study.

ERIC Educational Resources Information Center

Boord, Patricia M.

1998-01-01

To address diminishing resources and increased training demands, the Operational Training Unit (OTU) of the Federal Bureau of Investigation has saved almost $2 million by developing a distance education course to replace one full week of training at the FBI Academy. Discussion focuses on major issues faced by OTU in designing/delivering this…

28 CFR 8.5 - Appraisement of property subject to forfeiture.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Appraisement of property subject to forfeiture. 8.5 Section 8.5 Judicial Administration DEPARTMENT OF JUSTICE FBI FORFEITURE AUTHORITY FOR CERTAIN STATUTES § 8.5 Appraisement of property subject to forfeiture. Seized property shall be appraised...

28 CFR 8.5 - Appraisement of property subject to forfeiture.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Appraisement of property subject to forfeiture. 8.5 Section 8.5 Judicial Administration DEPARTMENT OF JUSTICE FBI FORFEITURE AUTHORITY FOR CERTAIN STATUTES § 8.5 Appraisement of property subject to forfeiture. Seized property shall be appraised...

28 CFR 8.2 - Designation of officials having seizure authority.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Designation of officials having seizure authority. 8.2 Section 8.2 Judicial Administration DEPARTMENT OF JUSTICE FBI FORFEITURE AUTHORITY FOR CERTAIN STATUTES § 8.2 Designation of officials having seizure authority. The Director, Associate Director...

Help for Finding Missing Children.

ERIC Educational Resources Information Center

McCormick, Kathleen

1984-01-01

Efforts to locate missing children have expanded from a federal law allowing for entry of information into an F.B.I. computer system to companion bills before Congress for establishing a national missing child clearinghouse and a Justice Department center to help in conducting searches. Private organizations are also involved. (KS)

28 CFR 8.9 - Disposition of forfeited property.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Disposition of forfeited property. 8.9 Section 8.9 Judicial Administration DEPARTMENT OF JUSTICE FBI FORFEITURE AUTHORITY FOR CERTAIN STATUTES § 8.9 Disposition of forfeited property. (a) If the laws of a state in which an article of forfeited...