Sample records for federal select agent

  1. 76 FR 14896 - Multi-Agency Informational Meeting Concerning Compliance With the Federal Select Agent Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-18

    ...] Multi-Agency Informational Meeting Concerning Compliance With the Federal Select Agent Program; Public... specific regulatory guidance related to the Federal Select Agent Program established under the Public.... Sarah Kwiatkowski, Veterinary Program Assistant, APHIS Select Agent Program, APHIS, 4700 River Road Unit...

  2. 76 FR 17617 - Multi-Agency Informational Meeting Concerning Compliance With the Federal Select Agent Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-30

    ...] Multi-Agency Informational Meeting Concerning Compliance With the Federal Select Agent Program; Public... specific regulatory guidance related to the Federal Select Agent Program established under the Public.... Sarah Kwiatkowski, Veterinary Program Assistant, APHIS Select Agent Program, APHIS, 4700 River Road Unit...

  3. 77 FR 56845 - Multi-Agency Informational Meeting Concerning Compliance With the Federal Select Agent Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-14

    ... Informational Meeting Concerning Compliance With the Federal Select Agent Program; Public Webcast AGENCY... with the Federal Select Agent Program. The purpose of this notice is to notify all interested parties... changes to the select agent regulations; occupational health, information and physical security; personnel...

  4. 75 FR 23223 - Multi-Agency Informational Meeting Concerning Compliance With the Federal Select Agent Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-03

    ...] Multi-Agency Informational Meeting Concerning Compliance With the Federal Select Agent Program; Public... Select Agent Program established under the Public Health Security and Bioterrorism Preparedness and... Roberson, Veterinary Permit Examiner, APHIS Select Agent Program, VS, ASAP, APHIS, 4700 River Road Unit 2...

  5. 76 FR 62312 - Multi-Agency Informational Meeting Concerning Compliance With the Federal Select Agent Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-07

    ... Select Agent Program; Public Meeting AGENCIES: Animal and Plant Health Inspection Service, USDA. ACTION... will be held to provide specific regulatory guidance related to the Federal Select Agent Program... Select Agent Program, APHIS, 4700 River Road, Unit 2, Riverdale, MD 20737; (301) 734-5960. CDC: Dr...

  6. Challenges and Practices in Building and Implementing Biosafety and Biosecurity Programs to Enable Basic and Translational Research with Select Agents.

    PubMed

    Jonsson, Colleen B; Cole, Kelly Stefano; Roy, Chad J; Perlin, David S; Byrne, Gerald

    2013-04-29

    Select agent research in the United States must meet federally-mandated biological surety guidelines and rules which are comprised of two main components: biosecurity and biosafety. Biosecurity is the process employed for ensuring biological agents are properly safeguarded against theft, loss, diversion, unauthorized access or use/release. Biosafety is those processes that ensure that operations with such agents are conducted in a safe, secure and reliable manner. As such, a biological surety program is generally concerned with biological agents that present high risk for adverse medical and/or agricultural consequences upon release outside of proper containment. The U.S. Regional and National Biocontainment Laboratories (RBL, NBL) represent expertise in this type of research, and are actively engaged in the development of programs to address these critical needs and federal requirements. While this comprises an ongoing activity for the RBLs, NBLs and other facilities that handle select agents as new guidelines and regulations are implemented, the present article is written with the goal of presenting a simplified yet comprehensive review of these requirements. Herein, we discuss the requirements and the various activities that the RBL/NBL programs have implemented to achieve these metrics set forth by various agencies within the U.S. Federal government.

  7. Challenges and Practices in Building and Implementing Biosafety and Biosecurity Programs to Enable Basic and Translational Research with Select Agents

    PubMed Central

    Jonsson, Colleen B.; Cole, Kelly Stefano; Roy, Chad J.; Perlin, David S.; Byrne, Gerald

    2014-01-01

    Select agent research in the United States must meet federally-mandated biological surety guidelines and rules which are comprised of two main components: biosecurity and biosafety. Biosecurity is the process employed for ensuring biological agents are properly safeguarded against theft, loss, diversion, unauthorized access or use/release. Biosafety is those processes that ensure that operations with such agents are conducted in a safe, secure and reliable manner. As such, a biological surety program is generally concerned with biological agents that present high risk for adverse medical and/or agricultural consequences upon release outside of proper containment. The U.S. Regional and National Biocontainment Laboratories (RBL, NBL) represent expertise in this type of research, and are actively engaged in the development of programs to address these critical needs and federal requirements. While this comprises an ongoing activity for the RBLs, NBLs and other facilities that handle select agents as new guidelines and regulations are implemented, the present article is written with the goal of presenting a simplified yet comprehensive review of these requirements. Herein, we discuss the requirements and the various activities that the RBL/NBL programs have implemented to achieve these metrics set forth by various agencies within the U.S. Federal government. PMID:24900945

  8. Detection of abrin holotoxin using novel monoclonal antibodies

    USDA-ARS?s Scientific Manuscript database

    Abrin, a member of ribosome-inactivating protein family, is produced by the Abrus precatorius plant. It has been determined to have the potential to pose a severe threat to both human and animal health and is listed as a select agent by the U.S. Federal Select Agent Program. However, an immunoassay ...

  9. 42 CFR 73.6 - Exemptions for overlap select agents and toxins.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... reported to CDC or APHIS and to other appropriate authorities when required by Federal, State, or local law... submission of APHIS/CDC Form 4 within seven calendar days after identification. (ii) For all other overlap select agents or toxins, APHIS/CDC Form 4 must be submitted within seven calendar days after...

  10. 42 CFR 73.6 - Exemptions for overlap select agents and toxins.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... reported to CDC or APHIS and to other appropriate authorities when required by Federal, State, or local law... submission of APHIS/CDC Form 4 within seven calendar days after identification. (ii) For all other overlap select agents or toxins, APHIS/CDC Form 4 must be submitted within seven calendar days after...

  11. 42 CFR 73.6 - Exemptions for overlap select agents and toxins.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... reported to CDC or APHIS and to other appropriate authorities when required by Federal, State, or local law... submission of APHIS/CDC Form 4 within seven calendar days after identification. (ii) For all other overlap select agents or toxins, APHIS/CDC Form 4 must be submitted within seven calendar days after...

  12. 42 CFR 73.6 - Exemptions for overlap select agents and toxins.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... reported to CDC or APHIS and to other appropriate authorities when required by Federal, State, or local law... pseudomallei. This report must be followed by submission of APHIS/CDC Form 4 within seven calendar days after identification. (ii) For all other overlap select agents or toxins, APHIS/CDC Form 4 must be submitted within...

  13. 42 CFR 73.6 - Exemptions for overlap select agents and toxins.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... reported to CDC or APHIS and to other appropriate authorities when required by Federal, State, or local law... pseudomallei. This report must be followed by submission of APHIS/CDC Form 4 within seven calendar days after identification. (ii) For all other overlap select agents or toxins, APHIS/CDC Form 4 must be submitted within...

  14. Biological Select Agents and Toxins: Risk-Based Assessment Management and Oversight.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Burnett, LouAnn Crawford; Brodsky, Benjamin H.

    Sandia National Laboratories' International Biological and Chemical Threat Reduction (SNL/IBCTR) conducted, on behalf of the Federal Select Agent Program (FSAP), a review of risk assessment in modern select agent laboratories. This review and analysis consisted of literature review, interviews of FSAP staff, entities regulated by FSAP, and deliberations of an expert panel. Additionally, SNL/IBCTR reviewed oversight mechanisms used by industries, US agencies, and other countries for high-consequence risks (e.g, nuclear, chemical, or biological materials, aviation, off-shore drilling, etc.) to determine if alternate oversight mechanisms existed that might be applicable to FSAP oversight of biological select agents and toxins. This reportmore » contains five findings, based on these reviews and analyses, with recommendations and suggested actions for FSAP to consider.« less

  15. Revised Study Design for Final Phase of the Change Agent Study. Study of Change Agent Programs: A Working Note.

    ERIC Educational Resources Information Center

    Bass, G.; And Others

    The Rand change agent study was designed to determine the factors for successful implementation and continuation of selected federal programs--the Elementary and Secondary Education Act, Title III, Innovation Projects; ESEA Title VII, Bilingual Projects; Vocational Education Part D, Exemplary Programs; and the Right-to-Read program. This report…

  16. Characterization of Departures from Regulatory Requirements Identified During Inspections Conducted by the US Federal Select Agent Program, 2014-15.

    PubMed

    Bjork, Adam; Sosin, Daniel M

    We studied departures from regulatory requirements identified on US Federal Select Agent Program (FSAP) inspections to increase transparency regarding biosafety and security risk at FSAP-regulated entities and identify areas for programmatic improvement. Regulatory departures from inspections led by Centers for Disease Control and Prevention inspectors during 2014-15 were grouped into "biosafety," "security," and "other" observation categories and assigned a risk level and score reflecting perceived severity. The resulting 2,267 biosafety (n = 1,153) and security (n = 1,114) observations from 296 inspections were analyzed by frequency and risk across entity and inspection characteristics. The greatest proportion of biosafety observations involved equipment and facilities (28%), and the greatest proportion of security observations involved access restrictions (33%). The greatest proportion of higher-risk observations for biosafety were containment issues and for security were inventory discrepancies. Commercial entities had the highest median cumulative risk score per inspection (17), followed by private (13), academic (10), federal government (10), and nonfederal government (8). Maximum containment (BSL-4) inspections had higher median biosafety risk per inspection (13) than other inspections (5) and lower security risk (0 vs 4). Unannounced inspections had proportionally more upper risk level observations than announced (biosafety, 21% vs 12%; security, 18% vs 7%). Possessors of select agents had higher median biosafety risk per inspection (6) than nonpossessors (4) and more upper risk level security observations (10% vs 0%). Programmatic changes to balance resources according to entity risk may strengthen FSAP oversight. Varying inspection methods by select agent possession and entity type, and conducting more unannounced inspections, may be beneficial.

  17. 7 CFR 613.2 - Policy and objectives.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... working with experiment stations, crop improvement associations, and other State and Federal agencies. (b... related to: (1) Controlling soil erosion on all lands; (2) Conserving water; (3) Protecting upstream... enhancement; (12) Selecting plants that tolerate air pollution agents and toxic soil chemicals; (13) Selecting...

  18. Method development for comprehensive extraction and analysis of marine toxins: Liquid-liquid extraction and tandem liquid chromatography separations coupled to electrospray tandem mass spectrometry

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wunschel, David S.; Valenzuela, Blandina R.; Kaiser, Brooke L. Deatherage

    Toxins from biological sources are recognized as potential chemical weapon threats, with saxitoxin and ricin listed by the chemical weapons convention (CWC) as schedule one agents (CWC reference). These two toxins represent a metabolite (saxitoxin) and protein (ricin) from algal and plant sources, respectively. An array of toxins have been listed as "select agents" by the Health and Human Services (HHS) select agent program, including ricin, abrin, saxitoxin, tetrodotoxin, specific paralytic alpha conotoxin peptides, T-2 toxin, diacetoxyscirpenols, botulinum toxins, and staphylococcal enterotoxins [1]. The quantities of these toxins dictate whether they are considered select agents with federal oversight of theirmore » storage and use. While this list captures some of the naturally occurring toxins that may pose a threat to the public, there are a number of other naturally occurring toxins that may also be a concern.« less

  19. Information security for compliance with select agent regulations.

    PubMed

    Lewis, Nick; Campbell, Mark J; Baskin, Carole R

    2015-01-01

    The past decade has seen a significant rise in research on high-consequence human and animal pathogens, many now known as "select agents." While physical security around these agents is tightly regulated, information security standards are still lagging. The understanding of the threats unique to the academic and research environment is still evolving, in part due to poor communication between the various stakeholders. Perhaps as a result, information security guidelines published by select agent regulators lack the critical details and directives needed to achieve even the lowest security level of the Federal Information Security Management Act (FISMA). While only government agencies are currently required to abide by the provisions of FISMA (unless specified as preconditions for obtaining government grants or contracts--still a relatively rare or narrowly scoped occurrence), the same strategies were recently recommended by executive order for others. We propose that information security guidelines for select agent research be updated to promulgate and detail FISMA standards and processes and that the latter be ultimately incorporated into select agent regulations. We also suggest that information security in academic and research institutions would greatly benefit from active efforts to improve communication among the biosecurity, security, and information technology communities, and from a secure venue for exchange of timely information on emerging threats and solutions in the research environment.

  20. Information Security for Compliance with Select Agent Regulations

    PubMed Central

    Lewis, Nick; Campbell, Mark J.

    2015-01-01

    The past decade has seen a significant rise in research on high-consequence human and animal pathogens, many now known as “select agents.” While physical security around these agents is tightly regulated, information security standards are still lagging. The understanding of the threats unique to the academic and research environment is still evolving, in part due to poor communication between the various stakeholders. Perhaps as a result, information security guidelines published by select agent regulators lack the critical details and directives needed to achieve even the lowest security level of the Federal Information Security Management Act (FISMA). While only government agencies are currently required to abide by the provisions of FISMA (unless specified as preconditions for obtaining government grants or contracts—still a relatively rare or narrowly scoped occurrence), the same strategies were recently recommended by executive order for others. We propose that information security guidelines for select agent research be updated to promulgate and detail FISMA standards and processes and that the latter be ultimately incorporated into select agent regulations. We also suggest that information security in academic and research institutions would greatly benefit from active efforts to improve communication among the biosecurity, security, and information technology communities, and from a secure venue for exchange of timely information on emerging threats and solutions in the research environment. PMID:26042864

  1. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Foust, C.B.

    An incident involving chemical warfare agents requires a unique hazardous materials (HAZMAT) response. As with an HAZMAT event, federal regulations prescribe that responders must be protected from exposure to the chemical agents. But unlike other HAZMAT events, special considerations govern selection of personal protective equipment (PPE). PPE includes all clothing, respirators and monitoring devices used to respond to a chemical release. PPE can differ depending on whether responders are military or civilian personnel.

  2. A New Approach To Secure Federated Information Bases Using Agent Technology.

    ERIC Educational Resources Information Center

    Weippi, Edgar; Klug, Ludwig; Essmayr, Wolfgang

    2003-01-01

    Discusses database agents which can be used to establish federated information bases by integrating heterogeneous databases. Highlights include characteristics of federated information bases, including incompatible database management systems, schemata, and frequently changing context; software agent technology; Java agents; system architecture;…

  3. Evaluation of yeasts obtained from Antarctic soil samples as biocontrol agents for the management of postharvest diseases of apple (Malus × domestica).

    PubMed

    Vero, Silvana; Garmendia, Gabriela; González, M Belén; Bentancur, Oscar; Wisniewski, Michael

    2013-03-01

    Psychrotrophic yeasts were isolated from Antarctic soils, selected based on their ability to grow in apple juice at low temperatures, and were evaluated as potential biocontrol agents for the management of postharvest diseases of apple during cold storage. Among the species recovered, an isolate of Leucosporidium scottii, designated At17, was identified as a good biocontrol agent for blue and gray mold of two apple cultivars. The selected isolate produced soluble and volatile antifungal substances that were inhibitory to apple pathogens. Siderophore production was also demonstrated, but it did not appear to play a role in pathogen inhibition. The selected yeast had the capacity to form a biofilm when grown in apple juice, which is considered an important attribute of postharvest antagonists to successfully colonize wounds and intact fruit surfaces. At17 was resistant to commonly used postharvest fungicides, so application of a combination of low-dose fungicide along with the biocontrol agent could be used as an integrated management practice. © 2012 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.

  4. 42 CFR 73.19 - Notification of theft, loss, or release.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... CDC or APHIS and appropriate Federal, State, or local law enforcement agencies. Thefts or losses must..., or intends to report the theft or loss. (2) A completed APHIS/CDC Form 3 must submitted within seven... individual or entity must immediately notify CDC or APHIS. (1) The release of a select agent or toxin must be...

  5. 42 CFR 73.19 - Notification of theft, loss, or release.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... CDC or APHIS and appropriate Federal, State, or local law enforcement agencies. Thefts or losses must..., or intends to report the theft or loss. (2) A completed APHIS/CDC Form 3 must submitted within seven... individual or entity must immediately notify CDC or APHIS. (1) The release of a select agent or toxin must be...

  6. 42 CFR 73.19 - Notification of theft, loss, or release.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... CDC or APHIS and appropriate Federal, State, or local law enforcement agencies. Thefts or losses must..., or intends to report the theft or loss. (2) A completed APHIS/CDC Form 3 must submitted within seven... individual or entity must immediately notify CDC or APHIS. (1) The release of a select agent or toxin must be...

  7. 42 CFR 73.19 - Notification of theft, loss, or release.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... CDC or APHIS and appropriate Federal, State, or local law enforcement agencies. Thefts or losses must..., or intends to report the theft or loss. (2) A completed APHIS/CDC Form 3 must submitted within seven... individual or entity must immediately notify CDC or APHIS. (1) The release of a select agent or toxin must be...

  8. 42 CFR 73.4 - Overlap select agents and toxins.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... the Federal Register and will be listed on the CDC Web site at http://www.cdc.gov/. (2) If an excluded... CDC or APHIS. (i) The seizure of Bacillus anthracis, Brucella melitensis, Hendra virus, Nipah virus... telephone, facsimile, or e-mail. This report must be followed by submission of APHIS/CDC Form 4 within seven...

  9. 42 CFR 73.19 - Notification of theft, loss, or release.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CDC or APHIS and appropriate Federal, State, or local law enforcement agencies. Thefts or losses must..., or intends to report the theft or loss. (2) A completed APHIS/CDC Form 3 must submitted within seven... individual or entity must immediately notify CDC or APHIS. (1) The release of a select agent or toxin must be...

  10. 31 CFR 210.7 - Federal Reserve Banks.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 2 2011-07-01 2011-07-01 false Federal Reserve Banks. 210.7 Section... CLEARING HOUSE General § 210.7 Federal Reserve Banks. (a) Fiscal Agents. Each Federal Reserve Bank serves... under this part. As Fiscal Agent, each Federal Reserve Bank shall be responsible only to the Treasury...

  11. 50 CFR 697.4 - Vessel permits and trap tags.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Port Agent Vessel Interview forms (NOAA Form 88-30), Federal Sea Sampling Observer Reports or a Federal... traps fished, including, but not limited to, state report cards, state vessel interview forms, license... (NOAA Form 88-30), Federal Port Agent Vessel Interview forms (NOAA Form 88-30) or Federal Sea Sampling...

  12. 50 CFR 697.4 - Vessel permits and trap tags.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Port Agent Vessel Interview forms (NOAA Form 88-30), Federal Sea Sampling Observer Reports or a Federal... traps fished, including, but not limited to, state report cards, state vessel interview forms, license... (NOAA Form 88-30), Federal Port Agent Vessel Interview forms (NOAA Form 88-30) or Federal Sea Sampling...

  13. 31 CFR 312.3 - Collections, investigations, and reports for the Federal Housing Administration.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PUBLIC DEBT FEDERAL SAVINGS AND LOAN ASSOCIATIONS AND FEDERAL CREDIT UNIONS AS FISCAL AGENTS OF THE.... Federal savings and loan associations, when designated for employment as fiscal agents of the United States for the purpose of collecting delinquent accounts arising out of insurance and loan transactions...

  14. 40 CFR 152.20 - Exemptions for pesticides adequately regulated by another Federal agency.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Federal agency. (a) Certain biological control agents. (1) Except as provided by paragraphs (a)(3) and (a)(4) of this section, all biological control agents are exempt from FIFRA requirements. (2) If the Agency determines that an individual biological control agent or class of biological control agents is no...

  15. 40 CFR 152.20 - Exemptions for pesticides adequately regulated by another Federal agency.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Federal agency. (a) Certain biological control agents. (1) Except as provided by paragraphs (a)(3) and (a)(4) of this section, all biological control agents are exempt from FIFRA requirements. (2) If the Agency determines that an individual biological control agent or class of biological control agents is no...

  16. 31 CFR 317.9 - Role of Federal Reserve Banks.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 2 2011-07-01 2011-07-01 false Role of Federal Reserve Banks. 317.9... UNITED STATES SAVINGS BONDS § 317.9 Role of Federal Reserve Banks. (a) Role as fiscal agents. In their capacity as fiscal agents of the United States, the Federal Reserve Banks referred to below are authorized...

  17. The legality of designating a union representative as the miners` walkaround representative at a non-unionized mine

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    Reflecting the need for miner participation in maintaining safe conditions in the nation`s mines, current federal law gives miners at each mining operation the right to appoint a representative to accompany federal inspectors on periodic mine inspections. The Federal Mine Safety and Health Act (Mine Act) grants the miners the right to choose this {open_quotes}walkaround{close_quotes} representative, and provides that the walkaround representative shall be given an opportunity to accompany a federal agent during an inspection of a mine for the purposes of aiding the inspection. The issue of the propriety of a non-employee union walkaround representative at a non-union minemore » was recently addressed in Kerr-McGee Coal Corp. v. Federal Mine Safety & Health Review Commission (Kerr-McGee) and Thunder Basin Coal Co. v. Federal Mine Safety & Health Review Commission (Thunder Basin). This Note is devoted to a discussion of Kerr-McGee and Thunder Basin. However, it is important to first briefly review the provision of the federal statutes that give rise to the controversy. The Note then explains how the statutes were interpreted by the Kerr-McGee and Thunder Basin courts. A reading of the two decisions makes it apparent that any group of employees of a non-unionized mine are free to select a non-employee union agent as their walkaround representative. Finally, the Note discusses the ramifications of the conclusions reached in Kerr-McGee and Thunder Basin on the future duties and behavior of mine operators, organized labor, and those designated as walkaround representatives.« less

  18. State-level legal preparedness for nuclear and radiological emergencies in the U.S.: a network analysis of state laws and regulations.

    PubMed

    Guclu, Hasan; Ferrell Bjerke, Elizabeth; Galvan, Jared; Sweeney, Patricia; Potter, Margaret A

    2014-01-01

    This study explored if and to what extent the laws of U.S. states mirrored the U.S. federal laws for responding to nuclear-radiological emergencies (NREs). Emergency laws from a 12-state sample and the federal government were retrieved and translated into numeric codes representing acting agents, their partner agents, and the purposes of activity in terms of preparedness, response, and recovery. We used network analysis to explore the relationships among agents in terms of legally directed NRE activities. States' legal networks for NREs appear as not highly inclusive, involving an average of 28% of agents among those specified in the federal laws. Certain agents are highly central in NRE networks, so that their capacity and effectiveness might strongly influence an NRE response. State-level lawmakers and planners might consider whether or not greater inclusion of agents, modeled on the federal government laws, would enhance their NRE laws and if more agents should be engaged in planning and policy-making for NRE incidents. Further research should explore if and to what extent legislated NRE directives impose constraints on practical response activities including emergency planning.

  19. Federal Programs Supporting Educational Change, Vol. 2: Factors Affecting Change Agent Projects.

    ERIC Educational Resources Information Center

    Berman, Paul; Pauly, Edward W.

    This second volume in the change-agent series reports the interim results of an exploratory statistical analysis of a survey of a nationwide sample of 293 change-agent projects funded by four federal demonstration programs--Elementary Secondary Education Act (ESEA) Title III, Innovative Projects; ESEA Title VII, Bilingual Projects; Vocational…

  20. 76 FR 80803 - Independent Expenditures and Electioneering Communications by Corporations and Labor Organizations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-27

    ... money, or any services, or anything of value * * * to any candidate, campaign committee, or political... candidate's authorized political committee, or their agents, or a political party committee and its agents... authorized by a Federal candidate or a Federal candidate's authorized political committee or its agents. 2 U...

  1. Federal Programs Supporting Educational Change, Vol. VII: Factors Affecting Implementation and Continuation.

    ERIC Educational Resources Information Center

    Berman, Paul; And Others

    This report is one of three volumes that describe the second phase of a study that examined the implementation of four federal change agent programs related to education. Phase 2 of the study focused on what happens to local projects in the two largest change agent programs--ESEA Title III and ESEA Title VII--when federal funding stops. This…

  2. [The actual Russian legislation in sphere of turn-over of drug agents and psychotropic substances].

    PubMed

    Abramov, A Yu; Kosolapova, N V; Mikhaiylova, Yu V

    2014-01-01

    The drug abuse is a social occurrence. Hence, the social economic methods are the first of all means of combating this evil. At the same time, measures of especially juridical character possess significant value since they develop corresponding legal base for applying another measures. In the Russian Federation, during fifteen years the new policy of public regulation and normative legal base in the area of legal turn-over of drug agents, psychotropic substances and their precursors were developed factually from zero ground. However, the current national legislation is not deprived of some flaws and contradictions. Frequently a uniform practice of interpretation and application of legal rules regulating the controlled turn-over is lacking. On the one hand, this circumstance decreases effectiveness of action of such rules and on the other hand favors development of situations for outflow of pharmaceuticals from legal turn-over to illegal traffic. The becoming of the Russian legislation in the area of turn-over of drug agents, precursors and psychotropic substances relates to the period of late 1990s when the Federal Law No 3 FZ "On drug agents and psychotropic substances" of January 8 1998 was developed and passed by the State Duma of the Russian Federation. The given law completely conforms to principles of legal regulation of turn-over of drug agents and psychotropic substances determined by the Constitution of the Russian Federation (provisions 76, 90, 104, 105) and federal laws ("On the government of the Russian Federation" of December 17 1997, "On the ombudsman in the Russian Federation" of February 26 1997). The main characteristic of legal rules included into given group of sources of law is that they contain regulations of general disposition as basic ones for inferior sources of law. The analysis of basic Federal law No 3 FZ "On drug agents and psychotropic substances" of January 8 1998 makes it possible to conclude that in in Russia the international legal acts are in the foundation of actual legal regulation of turn-over of drug agents and psychotropic substances.

  3. Medicaid program; adjustment of federal share for uncashed or cancelled (voided) checks--HCFA. Final rule.

    PubMed

    1986-10-09

    These final regulations require that a State agency refund to the Federal Government the Federal share of Medicaid checks issued by the State or its fiscal agent that remain uncashed 180 days after the date of issuance. In addition, we are requiring that the Federal share of cancelled (voided) Medicaid checks be refunded quarterly since there has been no expenditure by the State. These regulations implement, in part, a 1981 General Accounting Office recommendation that procedures be established for States to credit the Federal Government for the Federal portion of uncashed Medicaid checks issued by the State or its fiscal agent.

  4. 31 CFR Appendix B to Part 357 - TRADES Commentary

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... accounts. In TRADES, Treasury, through its fiscal agents, the Federal Reserve Banks, recognizes the identity only of Participants (persons with a direct account relationship with a Federal Reserve Bank... agents, will act only on instructions of the Participant in whose Securities Account the Treasury book...

  5. Medicaid program: adjustment of federal share for uncashed or cancelled (voided) checks--HCFA. Proposed rule.

    PubMed

    1985-05-31

    These proposed regulations require a State agency to refund to the Federal government the Federal share of Medicaid checks issued by the State or its fiscal agent that remain uncashed 180 days after the date of issuance. In addition, we would require that the Federal share of cancelled (voided) Medicaid checks be refunded quarterly since there has been no expenditure by the State. This proposal is intended to implement in part a 1981 General Accounting Office recommendation that procedures be established for States to credit the Federal government for its portion of uncashed Medicaid checks issues by the State or its fiscal agent.

  6. 12 CFR 545.16 - Public deposits, depositaries, and fiscal agents.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... FEDERAL SAVINGS ASSOCIATIONS-OPERATIONS § 545.16 Public deposits, depositaries, and fiscal agents. (a... constitution of the state with provisions respecting deposits of public money of that body; (3) Surety means... public deposits. (1) A Federal savings association that is a deposit association may give bond or...

  7. 12 CFR 145.16 - Public deposits, depositaries, and fiscal agents.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... FEDERAL SAVINGS ASSOCIATIONS-OPERATIONS § 145.16 Public deposits, depositaries, and fiscal agents. (a... constitution of the state with provisions respecting deposits of public money of that body; (3) Surety means... public deposits. (1) A Federal savings association that is a deposit association may give bond or...

  8. 12 CFR 545.16 - Public deposits, depositaries, and fiscal agents.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... FEDERAL SAVINGS ASSOCIATIONS-OPERATIONS § 545.16 Public deposits, depositaries, and fiscal agents. (a... constitution of the state with provisions respecting deposits of public money of that body; (3) Surety means... public deposits. (1) A Federal savings association that is a deposit association may give bond or...

  9. 12 CFR 145.16 - Public deposits, depositaries, and fiscal agents.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... FEDERAL SAVINGS ASSOCIATIONS-OPERATIONS § 145.16 Public deposits, depositaries, and fiscal agents. (a... constitution of the state with provisions respecting deposits of public money of that body; (3) Surety means... public deposits. (1) A Federal savings association that is a deposit association may give bond or...

  10. 12 CFR 725.7 - Special share accounts in federally chartered agent members.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Special share accounts in federally chartered agent members. 725.7 Section 725.7 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS NATIONAL CREDIT UNION ADMINISTRATION CENTRAL LIQUIDITY FACILITY § 725.7 Special...

  11. 34 CFR 682.408 - Loan disbursement through an escrow agent.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION FEDERAL FAMILY EDUCATION LOAN (FFEL) PROGRAM Administration of the Federal Family Education Loan Programs by a Guaranty Agency § 682.408 Loan disbursement through an... 34 Education 3 2010-07-01 2010-07-01 false Loan disbursement through an escrow agent. 682.408...

  12. BSL-3 laboratory practices in the United States: comparison of select agent and non-select agent facilities.

    PubMed

    Richards, Stephanie L; Pompei, Victoria C; Anderson, Alice

    2014-01-01

    New construction of biosafety level 3 (BSL-3) laboratories in the United States has increased in the past decade to facilitate research on potential bioterrorism agents. The Centers for Disease Control and Prevention inspect BSL-3 facilities and review commissioning documentation, but no single agency has oversight over all BSL-3 facilities. This article explores the extent to which standard operating procedures in US BSL-3 facilities vary between laboratories with select agent or non-select agent status. Comparisons are made for the following variables: personnel training, decontamination, personal protective equipment (PPE), medical surveillance, security access, laboratory structure and maintenance, funding, and pest management. Facilities working with select agents had more complex training programs and decontamination procedures than non-select agent facilities. Personnel working in select agent laboratories were likely to use powered air purifying respirators, while non-select agent laboratories primarily used N95 respirators. More rigorous medical surveillance was carried out in select agent workers (although not required by the select agent program) and a higher level of restrictive access to laboratories was found. Most select agent and non-select agent laboratories reported adequate structural integrity in facilities; however, differences were observed in personnel perception of funding for repairs. Pest management was carried out by select agent personnel more frequently than non-select agent personnel. Our findings support the need to promote high quality biosafety training and standard operating procedures in both select agent and non-select agent laboratories to improve occupational health and safety.

  13. BSL-3 Laboratory Practices in the United States: Comparison of Select Agent and Non–Select Agent Facilities

    PubMed Central

    Pompei, Victoria C.; Anderson, Alice

    2014-01-01

    New construction of biosafety level 3 (BSL-3) laboratories in the United States has increased in the past decade to facilitate research on potential bioterrorism agents. The Centers for Disease Control and Prevention inspect BSL-3 facilities and review commissioning documentation, but no single agency has oversight over all BSL-3 facilities. This article explores the extent to which standard operating procedures in US BSL-3 facilities vary between laboratories with select agent or non–select agent status. Comparisons are made for the following variables: personnel training, decontamination, personal protective equipment (PPE), medical surveillance, security access, laboratory structure and maintenance, funding, and pest management. Facilities working with select agents had more complex training programs and decontamination procedures than non–select agent facilities. Personnel working in select agent laboratories were likely to use powered air purifying respirators, while non–select agent laboratories primarily used N95 respirators. More rigorous medical surveillance was carried out in select agent workers (although not required by the select agent program) and a higher level of restrictive access to laboratories was found. Most select agent and non–select agent laboratories reported adequate structural integrity in facilities; however, differences were observed in personnel perception of funding for repairs. Pest management was carried out by select agent personnel more frequently than non–select agent personnel. Our findings support the need to promote high quality biosafety training and standard operating procedures in both select agent and non–select agent laboratories to improve occupational health and safety. PMID:24552359

  14. After Terror Charges, Artist Exhibits Academic Freedom

    ERIC Educational Resources Information Center

    Wilson, Robin

    2008-01-01

    Steven Kurtz, a professor of visual studies at the State University of New York, has been working with various bacteria as part of his counterculture exhibit artworks for nearly 20 years. Four years ago, federal agents raided his home in a bioterrorism investigation. The federal agents had been called to the house by local police officers…

  15. 77 FR 20123 - Fee Change for Paying Agents Redeeming Definitive Savings Bonds and Savings Notes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-03

    ... notes from the EZ CLEAR process to an existing image-based process through the Federal Reserve. This simple and modern process allows paying agents to electronically transmit images of redeemed definitive savings bonds and savings notes to a Federal Reserve Processing Site for payment. Because the new process...

  16. 31 CFR 224.2 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.2... surety bond. (b) Process agent means a resident agent for service of process. (c) State means a State...

  17. 31 CFR 224.2 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.2... surety bond. (b) Process agent means a resident agent for service of process. (c) State means a State...

  18. 31 CFR 224.2 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.2... surety bond. (b) Process agent means a resident agent for service of process. (c) State means a State...

  19. 24 CFR 81.95 - Authority of Federal Reserve Banks.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Authority of Federal Reserve Banks... Authority of Federal Reserve Banks. (a) Each Federal Reserve Bank is hereby authorized as fiscal agent of..., Federal Reserve Bank Operating Circulars, this subpart H, and procedures established by the Secretary...

  20. 42 CFR 73.11 - Security.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... select agent or toxin against unauthorized access, theft, loss, or release. (b) The security plan must be... activities, loss or theft of select agents or toxins, release of select agents or toxins, or alteration of... of select agents or toxins, (iv) Any release of a select agent or toxin, and (v) Any sign that...

  1. 9 CFR 121.11 - Security.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... the select agent or toxin against unauthorized access, theft, loss, or release. (b) The security plan... activities, loss or theft of select agents or toxins, release of select agents or toxins, or alteration of... of select agents or toxins; (iv) Any release of a select agent or toxin; and (v) Any sign that...

  2. 31 CFR 312.4 - Bond of indemnity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., DEPARTMENT OF THE TREASURY BUREAU OF THE PUBLIC DEBT FEDERAL SAVINGS AND LOAN ASSOCIATIONS AND FEDERAL CREDIT UNIONS AS FISCAL AGENTS OF THE UNITED STATES § 312.4 Bond of indemnity. No Federal savings and loan... of $1,000 and until the Federal Home Loan Bank Board or the Bureau of Federal Credit Unions...

  3. 76 FR 62412 - Agency Forms Undergoing Paperwork Reduction Act Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-07

    ... for Registration, (2) Request to Transfer Select Agent or Toxin, (3) Report of Theft, Loss, or Release..., or Release of Select Agent and Toxin, (4) Report of Identification of Select Agent or Toxin. There... Release of Select Agent or Toxin; (4) Report of Identification of Select Agent or Toxin; and (5) Request...

  4. 9 CFR 121.4 - Overlap select agents and toxins.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... select agent or toxin to APHIS or CDC. (i) The seizure of any of the following overlap select agents and.... This report must be followed by submission of APHIS/CDC Form 4 within 7 calendar days after seizure of the overlap select agent or toxin. (ii) For all other overlap select agents or toxins, APHIS/CDC Form...

  5. 12 CFR 811.7 - Servicing book-entry Federal Financing Bank securities; payment of interest; payment at maturity...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 7 2014-01-01 2014-01-01 false Servicing book-entry Federal Financing Bank... FEDERAL FINANCING BANK BOOK-ENTRY PROCEDURE FOR FEDERAL FINANCING BANK SECURITIES § 811.7 Servicing book... becoming due on book-entry Federal Financing Bank securities shall be charged against the special agent...

  6. 77 FR 71702 - Possession, Use, and Transfer of Select Agents and Toxins; Biennial Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-04

    ... of Select Agents and Toxins; Biennial Review AGENCY: Centers for Disease Control and Prevention (CDC... designated certain select agents and toxins as Tier 1 agents. DATES: Effective Date: Effective December 4, 2012. FOR FURTHER INFORMATION CONTACT: Robbin Weyant, Director, Division of Select Agents and Toxins...

  7. Infrared point sensors for homeland defense applications

    NASA Astrophysics Data System (ADS)

    Thomas, Ross C.; Carter, Michael T.; Homrighausen, Craig L.

    2004-03-01

    We report recent progress toward the development of infrared point sensors for the detection of chemical warfare agents and explosive related chemicals, which pose a significant threat to both health and environment. Technical objectives have focused on the development of polymer sorbents to enhance the infrared response of these hazardous organic compounds. For example, infrared point sensors which part-per-billion detection limits have been developed that rapidlypartition chemical warfare agents and explosive related chemicals into polymer thin films with desirable chemical and physical properties. These chemical sensors demonstrate novel routes to reversible sensing of hazardous organic compounds. The development of small, low-power, sensitive, and selective instruments employing these chemical sensors would enhance the capabilities of federal, state, and local emergency response to incidents involving chemical terrorism. Specific applications include chemical defense systems for military personnel and homeland defense, environmental monitors for remediation and demilitarization, and point source detectors for emergency and maintenance response teams.

  8. 14 CFR 121.269 - Extinguishing agent container compartment temperature.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... temperature. 121.269 Section 121.269 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF....269 Extinguishing agent container compartment temperature. Precautions must be taken to insure that the extinguishing agent containers are installed in places where reasonable temperatures can be...

  9. 14 CFR 121.269 - Extinguishing agent container compartment temperature.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... temperature. 121.269 Section 121.269 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF....269 Extinguishing agent container compartment temperature. Precautions must be taken to insure that the extinguishing agent containers are installed in places where reasonable temperatures can be...

  10. 14 CFR 121.269 - Extinguishing agent container compartment temperature.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... temperature. 121.269 Section 121.269 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF....269 Extinguishing agent container compartment temperature. Precautions must be taken to insure that the extinguishing agent containers are installed in places where reasonable temperatures can be...

  11. 14 CFR 121.269 - Extinguishing agent container compartment temperature.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... temperature. 121.269 Section 121.269 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF....269 Extinguishing agent container compartment temperature. Precautions must be taken to insure that the extinguishing agent containers are installed in places where reasonable temperatures can be...

  12. 14 CFR 121.269 - Extinguishing agent container compartment temperature.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... temperature. 121.269 Section 121.269 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF....269 Extinguishing agent container compartment temperature. Precautions must be taken to insure that the extinguishing agent containers are installed in places where reasonable temperatures can be...

  13. Design of a Mobile Agent-Based Adaptive Communication Middleware for Federations of Critical Infrastructure Simulations

    NASA Astrophysics Data System (ADS)

    Görbil, Gökçe; Gelenbe, Erol

    The simulation of critical infrastructures (CI) can involve the use of diverse domain specific simulators that run on geographically distant sites. These diverse simulators must then be coordinated to run concurrently in order to evaluate the performance of critical infrastructures which influence each other, especially in emergency or resource-critical situations. We therefore describe the design of an adaptive communication middleware that provides reliable and real-time one-to-one and group communications for federations of CI simulators over a wide-area network (WAN). The proposed middleware is composed of mobile agent-based peer-to-peer (P2P) overlays, called virtual networks (VNets), to enable resilient, adaptive and real-time communications over unreliable and dynamic physical networks (PNets). The autonomous software agents comprising the communication middleware monitor their performance and the underlying PNet, and dynamically adapt the P2P overlay and migrate over the PNet in order to optimize communications according to the requirements of the federation and the current conditions of the PNet. Reliable communications is provided via redundancy within the communication middleware and intelligent migration of agents over the PNet. The proposed middleware integrates security methods in order to protect the communication infrastructure against attacks and provide privacy and anonymity to the participants of the federation. Experiments with an initial version of the communication middleware over a real-life networking testbed show that promising improvements can be obtained for unicast and group communications via the agent migration capability of our middleware.

  14. 31 CFR 224.4 - When must a surety corporation appoint a process agent?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... a process agent? 224.4 Section 224.4 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.4 When must a surety corporation appoint a process agent? A...

  15. 31 CFR 224.4 - When must a surety corporation appoint a process agent?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... a process agent? 224.4 Section 224.4 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.4 When must a surety corporation appoint a process agent? A...

  16. 31 CFR 224.4 - When must a surety corporation appoint a process agent?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... appoint a process agent? 224.4 Section 224.4 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.4 When must a surety corporation appoint a process agent? A...

  17. 31 CFR 224.4 - When must a surety corporation appoint a process agent?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... a process agent? 224.4 Section 224.4 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.4 When must a surety corporation appoint a process agent? A...

  18. 31 CFR 309.13 - Functions of Federal Reserve Banks.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Functions of Federal Reserve Banks. 309.13 Section 309.13 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued... § 309.13 Functions of Federal Reserve Banks. Federal Reserve Banks and Branches, as fiscal agents of the...

  19. 31 CFR 354.6 - Authority of Federal Reserve Banks.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 2 2011-07-01 2011-07-01 false Authority of Federal Reserve Banks... SECURITIES OF THE STUDENT LOAN MARKETING ASSOCIATION (SALLIE MAE) § 354.6 Authority of Federal Reserve Banks. (a) Each Federal Reserve Bank is hereby authorized as fiscal agent of Sallie Mae to perform functions...

  20. 31 CFR 309.13 - Functions of Federal Reserve Banks.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 2 2011-07-01 2011-07-01 false Functions of Federal Reserve Banks. 309.13 Section 309.13 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued... § 309.13 Functions of Federal Reserve Banks. Federal Reserve Banks and Branches, as fiscal agents of the...

  1. Disaster preparedness in biocontainment animal research facilities: developing and implementing an incident response plan (IRP).

    PubMed

    Swearengen, James R; Vargas, Karen J; Tate, Mallory K; Linde, N S

    2010-01-01

    Preparing for the wide variety of disasters that can occur is challenging for any animal research facility, but the level of concern for human and animal health rises significantly when infectious agents and toxins are part of the scenario. Federal regulations provide detailed requirements for the development of an incident response plan (IRP) when select agents and toxins (SATs) are used. In addition to the usual issues associated with disaster planning, the IRP must address concerns associated with the potential theft, loss, or release of SATs that may affect both institutional personnel and the surrounding community. The level of detail in the IRP and the intensity of training should be appropriate for the level of risk involved. Regulations describe certain basic requirements but do not address the risks of SAT-exposed animals, which have been the subject of additional guidance to help implement regulatory requirements. A 2008 joint publication of the Centers for Disease Control and Prevention and the Animal and Plant Health Inspection Service describes scenarios in which SAT-exposed animals are handled in the same manner as the agent or toxin itself for the purpose of reporting a SAT theft, loss, or release. Events that resulted from the impact of Hurricane Ike at the University of Texas Medical Branch in Galveston provide a valuable opportunity to evaluate the effectiveness of the federal regulations and to build on lessons learned from this disaster. These lessons can help to supplement the regulatory requirements and improve the safety and security of handling both SATs and animals exposed to them during and after an emergency situation.

  2. 14 CFR 125.167 - Extinguishing agent container compartment temperature.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... temperature. 125.167 Section 125.167 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Requirements § 125.167 Extinguishing agent container compartment temperature. Precautions must be taken to ensure that the extinguishing agent containers are installed in places where reasonable temperatures can...

  3. 14 CFR 125.167 - Extinguishing agent container compartment temperature.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... temperature. 125.167 Section 125.167 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Requirements § 125.167 Extinguishing agent container compartment temperature. Precautions must be taken to ensure that the extinguishing agent containers are installed in places where reasonable temperatures can...

  4. 14 CFR 125.167 - Extinguishing agent container compartment temperature.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... temperature. 125.167 Section 125.167 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Requirements § 125.167 Extinguishing agent container compartment temperature. Precautions must be taken to ensure that the extinguishing agent containers are installed in places where reasonable temperatures can...

  5. 14 CFR 125.167 - Extinguishing agent container compartment temperature.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... temperature. 125.167 Section 125.167 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Requirements § 125.167 Extinguishing agent container compartment temperature. Precautions must be taken to ensure that the extinguishing agent containers are installed in places where reasonable temperatures can...

  6. 14 CFR 125.167 - Extinguishing agent container compartment temperature.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... temperature. 125.167 Section 125.167 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Requirements § 125.167 Extinguishing agent container compartment temperature. Precautions must be taken to ensure that the extinguishing agent containers are installed in places where reasonable temperatures can...

  7. 48 CFR 3.502-2 - Subcontractor kickbacks.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Subcontractor kickbacks. 3.502-2 Section 3.502-2 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL...., company ethics rules prohibiting kickbacks by employees, agents, or subcontractors; education programs for...

  8. 31 CFR 224.3 - When may a surety corporation provide a bond without appointing a process agent?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.3 When may a surety corporation provide a bond without appointing a process agent? A surety corporation may provide a bond without... a bond without appointing a process agent? 224.3 Section 224.3 Money and Finance: Treasury...

  9. 31 CFR 224.3 - When may a surety corporation provide a bond without appointing a process agent?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.3 When may a surety corporation... appointing a process agent when the State where the bond is filed, the State where the principal resides, and...

  10. 76 FR 30092 - Notice of Request for Extension of Approval of an Information Collection; Select Agent Registration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-24

    ...] Notice of Request for Extension of Approval of an Information Collection; Select Agent Registration... . FOR FURTHER INFORMATION CONTACT: For information regarding the select agent registration process... Dr. Charles Divan, Branch Chief, Agriculture Select Agent Program, RIPPS, PPQ, APHIS, 4700 River Road...

  11. 78 FR 56234 - Multi-Agency Informational Meeting Concerning Compliance with the Select Agent Regulations...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-12

    ... Informational Meeting Concerning Compliance with the Select Agent Regulations; Public Webcast AGENCY: Centers... purpose of the webcast is to provide guidance related to the select agent regulations established under... Justice Information Services. Changes to Section 11(Security) of the select agent regulations including...

  12. 76 FR 16843 - Order Cancelling Registrations of Certain Transfer Agents

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-25

    ... SECURITIES AND EXCHANGE COMMISSION [Release No. 34-64102] Order Cancelling Registrations of Certain Transfer Agents March 21, 2011. On November 4, 2010, notice was published in the Federal Register... transfer agents.\\2\\ For the reasons discussed below, the Commission is cancelling the registration of the...

  13. 31 CFR 224.1 - What does this part cover?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY... appoint a service of process agent and how the surety corporation complies with this requirement. ...

  14. 31 CFR 224.1 - What does this part cover?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY... appoint a service of process agent and how the surety corporation complies with this requirement. ...

  15. 31 CFR 224.1 - What does this part cover?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY... appoint a service of process agent and how the surety corporation complies with this requirement. ...

  16. 31 CFR 224.1 - What does this part cover?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY... appoint a service of process agent and how the surety corporation complies with this requirement. ...

  17. 31 CFR 224.5 - Who may a surety corporation appoint to be a process agent?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... to be a process agent? 224.5 Section 224.5 Money and Finance: Treasury Regulations Relating to Money... FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.5 Who may a surety corporation appoint to be a process agent? A surety corporation may appoint either of the following as process agent—(a) An official of the...

  18. 34 CFR 668.61 - Recovery of funds.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... in which the institution disbursed Federal Pell Grant, ACG, National SMART Grant, Federal Perkins... escrow agent any disbursement not yet delivered to the student that exceeds the amount of assistance for...

  19. 49 CFR Appendix B to Subchapter B... - Special Agents

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 5 2013-10-01 2013-10-01 false Special Agents B Appendix B to Subchapter B of Chapter III Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER..., Subch. B, App. B Appendix B to Subchapter B of Chapter III—Special Agents Cautionary note: This appendix...

  20. 49 CFR Appendix B to Subchapter B... - Special Agents

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 5 2014-10-01 2014-10-01 false Special Agents B Appendix B to Subchapter B of Chapter III Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER..., Subch. B, App. B Appendix B to Subchapter B of Chapter III—Special Agents Cautionary note: This appendix...

  1. 49 CFR Appendix B to Subchapter B... - Special Agents

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 5 2012-10-01 2012-10-01 false Special Agents B Appendix B to Subchapter B of Chapter III Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER..., Subch. B, App. B Appendix B to Subchapter B of Chapter III—Special Agents Cautionary note: This appendix...

  2. 5 CFR 582.201 - Agent to receive process.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Agent to receive process. 582.201 Section 582.201 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS COMMERCIAL GARNISHMENT OF FEDERAL EMPLOYEES' PAY Service of Legal Process § 582.201 Agent to receive process. (a) Except...

  3. 5 CFR 582.201 - Agent to receive process.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Agent to receive process. 582.201 Section 582.201 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS COMMERCIAL GARNISHMENT OF FEDERAL EMPLOYEES' PAY Service of Legal Process § 582.201 Agent to receive process. (a) Except...

  4. 5 CFR 582.201 - Agent to receive process.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Agent to receive process. 582.201 Section 582.201 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS COMMERCIAL GARNISHMENT OF FEDERAL EMPLOYEES' PAY Service of Legal Process § 582.201 Agent to receive process. (a) Except...

  5. 5 CFR 582.201 - Agent to receive process.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Agent to receive process. 582.201 Section 582.201 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS COMMERCIAL GARNISHMENT OF FEDERAL EMPLOYEES' PAY Service of Legal Process § 582.201 Agent to receive process. (a) Except...

  6. 5 CFR 582.201 - Agent to receive process.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Agent to receive process. 582.201 Section 582.201 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS COMMERCIAL GARNISHMENT OF FEDERAL EMPLOYEES' PAY Service of Legal Process § 582.201 Agent to receive process. (a) Except...

  7. 78 FR 15046 - InfraGard Membership Application and Profile Proposed Collection, Comments Requested; InfraGard...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-08

    ... Department of Justice (DOJ), Federal Bureau of Investigation (FBI), Cyber Division's National Industry... Agent, National Industry Partnerships Unit, Federal Bureau of Investigation, Cyber Division, FBIHQ, 935... Industry Partnership Unit (NIPU) Cyber Division of the Federal Bureau of Investigation (FBI), Department of...

  8. 40 CFR 82.68 - Verification and public notice requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., any person who sells or distributes any mold release agents containing a class II substance as a... federal law to sell mold release agents containing hydrochlorofluorocarbons as propellants to anyone...

  9. 75 FR 7548 - Amendments to the Select Agents Controls in Export Control Classification Number (ECCN) 1C360 on...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-22

    ...-91434-01] RIN 0694-AE67 Amendments to the Select Agents Controls in Export Control Classification Number... controls on certain select agents identified in Export Control Classification Number (ECCN) 1C360 on the...) list of select agents and toxins. The changes made by APHIS were part of a biennial review and...

  10. 31 CFR 224.8 - When must a surety corporation appoint a new process agent?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... a new process agent? 224.8 Section 224.8 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.8 When must a surety corporation appoint a new process...

  11. 31 CFR 224.8 - When must a surety corporation appoint a new process agent?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... a new process agent? 224.8 Section 224.8 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.8 When must a surety corporation appoint a new process...

  12. 31 CFR 224.8 - When must a surety corporation appoint a new process agent?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... appoint a new process agent? 224.8 Section 224.8 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.8 When must a surety corporation appoint a new process...

  13. 31 CFR 224.3 - When may a surety corporation provide a bond without appointing a process agent?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... a bond without appointing a process agent? 224.3 Section 224.3 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.3 When may a surety corporation...

  14. 31 CFR 224.3 - When may a surety corporation provide a bond without appointing a process agent?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... a bond without appointing a process agent? 224.3 Section 224.3 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.3 When may a surety corporation...

  15. 31 CFR 224.8 - When must a surety corporation appoint a new process agent?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... a new process agent? 224.8 Section 224.8 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.8 When must a surety corporation appoint a new process...

  16. 17 CFR 259.602 - Form ID, uniform application for access codes to file on EDGAR.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...)—allows a filer, filing agent or training agent to log on to the EDGAR system, submit filings, and change... agent to change its Password. [69 FR 22710, Apr. 26, 2004] Editorial Note: For Federal Register... section of the printed volume and at at www.fdsys.gov. ...

  17. 17 CFR 259.602 - Form ID, uniform application for access codes to file on EDGAR.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...)—allows a filer, filing agent or training agent to log on to the EDGAR system, submit filings, and change... agent to change its Password. [69 FR 22710, Apr. 26, 2004] Editorial Note: For Federal Register... section of the printed volume and on GPO Access. ...

  18. Federal Programs Supporting Educational Change, Vol. 5: Executive Summary.

    ERIC Educational Resources Information Center

    Berman, Paul; And Others

    Under the sponsorship of the U. S. Office of Education, Rand is conducting a several-year study of federally funded programs designed to introduce and spread innovative practices in public schools. These change agent programs normally offer temporary federal funding to school districts as "seed money" or "risk capital." If an…

  19. 76 FR 29754 - Proposed Data Collections Submitted for Public Comment and Recommendations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-23

    ... Agent or Toxin, (3) Report of Theft, Loss, or Release of Select Agent and Toxin, (4) Report of..., Use, and Transfer of Select Agents and Toxins (OMB Control No. 0920-0576)--Revision--Office of Public Health Preparedness and Response (OPHPR), Division of Select Agents and Toxins, Centers for Disease...

  20. Emergence of social structures via preferential selection

    NASA Astrophysics Data System (ADS)

    Lipowski, Adam; Lipowska, Dorota; Ferreira, Antonio Luis

    2014-09-01

    We examine a weighted-network multiagent model with preferential selection such that agents choose partners with probability p (w), where w is the number of their past selections. When p (w) increases sublinearly with the number of past selections [p(w)˜wα,α<1], agents develop a uniform preference for all other agents. At α =1, this state loses stability and more complex structures form. For a superlinear increase (α>1), strong heterogeneities emerge and agents make selections mainly within small and sometimes asymmetric clusters. Even in a few-agent case, the formation of such clusters resembles phase transitions with spontaneous symmetry breaking.

  1. 42 CFR 73.3 - HHS select agents and toxins.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... been genetically modified. (d) HHS select agents or toxins that meet any of the following criteria are... Recombinant Organisms: (1) Nucleic acids that can produce infectious forms of any of the select agent viruses...

  2. 31 CFR 224.5 - Who may a surety corporation appoint to be a process agent?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... to be a process agent? 224.5 Section 224.5 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.5 Who may a surety corporation appoint to be a process...

  3. 31 CFR 224.5 - Who may a surety corporation appoint to be a process agent?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... to be a process agent? 224.5 Section 224.5 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.5 Who may a surety corporation appoint to be a process...

  4. 31 CFR 224.5 - Who may a surety corporation appoint to be a process agent?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... to be a process agent? 224.5 Section 224.5 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.5 Who may a surety corporation appoint to be a process...

  5. Selective Attention and Control of Action: Comparative Psychology of an Artificial, Evolved Agent and People

    ERIC Educational Resources Information Center

    Ward, Robert; Ward, Ronnie

    2008-01-01

    This study examined the selective attention abilities of a simple, artificial, evolved agent and considered implications of the agent's performance for theories of selective attention and action. The agent processed two targets in continuous time, catching one and then the other. This task required many cognitive operations, including prioritizing…

  6. 41 CFR 102-77.20 - With whom should Federal agencies collaborate with when commissioning and selecting art for...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... agencies collaborate with when commissioning and selecting art for Federal buildings? 102-77.20 Section 102... (Continued) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 77-ART-IN-ARCHITECTURE Art-in-Architecture § 102-77.20 With whom should Federal agencies collaborate with when commissioning and selecting art for...

  7. Health effects research program. Summary report for fiscal years 1974-1978

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Thomas, R.D.; Taylor, A.D.; Gordon, J.G.

    1979-12-01

    The Federal Interagency Energy/Environment Research and Development Program which is coordinated by the U.S. Environmental Protection Agency was initiated in the latter half of fiscal year 1974 to ensure that health and environmental problems related to energy resource development would be anticipated and evaluated. This document provides an overview of the Interagency-supported health effects research program from an administrative as well as various technical perspectives. In this updated program review, which is based on the individual task progress reports available for fiscal years 1974 through 1978, the research projects are reviewed and discussed according to King-Muir objectives and selected scientificmore » discipline, biological endpoint, and agent/pollutant categories.« less

  8. Selective attention and control of action: comparative psychology of an artificial, evolved agent and people.

    PubMed

    Ward, Robert; Ward, Ronnie

    2008-10-01

    This study examined the selective attention abilities of a simple, artificial, evolved agent and considered implications of the agent's performance for theories of selective attention and action. The agent processed two targets in continuous time, catching one and then the other. This task required many cognitive operations, including prioritizing the first target (T1) over the second (T2); selectively focusing responses on T1, while preventing T2 from interfering with responses; creating a memory for the unselected T2 item, so that it could be efficiently processed later; and reallocating processing towards T2 after catching T1. The evolved agent demonstrated all these abilities. Analysis shows that the agent used reactive inhibition to selectively focus behavior. That is, the more salient T2, the more strongly responses towards T2 were inhibited and the slower the agent was to subsequently reallocate processing towards T2. Reactive inhibition was also suggested in two experiments with people, performing a virtually identical catch task. The presence of reactive inhibition in the simple agent and in people suggests that it is an important mechanism for selective processing.

  9. Multi-agent Reinforcement Learning Model for Effective Action Selection

    NASA Astrophysics Data System (ADS)

    Youk, Sang Jo; Lee, Bong Keun

    Reinforcement learning is a sub area of machine learning concerned with how an agent ought to take actions in an environment so as to maximize some notion of long-term reward. In the case of multi-agent, especially, which state space and action space gets very enormous in compared to single agent, so it needs to take most effective measure available select the action strategy for effective reinforcement learning. This paper proposes a multi-agent reinforcement learning model based on fuzzy inference system in order to improve learning collect speed and select an effective action in multi-agent. This paper verifies an effective action select strategy through evaluation tests based on Robocop Keep away which is one of useful test-beds for multi-agent. Our proposed model can apply to evaluate efficiency of the various intelligent multi-agents and also can apply to strategy and tactics of robot soccer system.

  10. 25 CFR 23.12 - Designated tribal agent for service of notice.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... pursuant to 25 U.S.C. 1912 may designate by resolution, or by such other form as the tribe's constitution... shall update and publish as necessary the names and addresses of the designated agents in the Federal...

  11. 12 CFR 1209.71 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Banking FEDERAL HOUSING FINANCE AGENCY ORGANIZATION AND OPERATIONS RULES OF PRACTICE AND PROCEDURE Parties and Representational Practice Before the Federal Housing Finance Agency; Standards of Conduct § 1209... limited to, transacting any business with FHFA as counsel of record, representative, or agent for any...

  12. The Curricular Indian Agent: Discursive Colonization and Indigenous (Dys)Agency in U.S. History Textbooks

    ERIC Educational Resources Information Center

    Stanton, Christine Rogers

    2014-01-01

    In the 1800s and early 1900s, the United States assigned Indian Agents--non-Native employees of the federal government--to coordinate intergovernmental efforts, to encourage the assimilation of Native peoples into European-American society, and to serve as advocates for individual tribes. Although Indian Agents no longer exist in an official…

  13. 31 CFR 375.3 - What is the role of the Federal Reserve Bank of New York in this process?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Reserve Bank of New York in this process? 375.3 Section 375.3 Money and Finance: Treasury Regulations... of the Federal Reserve Bank of New York in this process? As fiscal agent of the United States, the Federal Reserve Bank of New York performs various activities necessary to conduct a redemption operation...

  14. 76 FR 77914 - Agricultural Bioterrorism Protection Act of 2002; Biennial Review and Republication of the Select...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-15

    ... Bioterrorism Protection Act of 2002; Biennial Review and Republication of the Select Agent and Toxin List; Amendments to the Select Agent and Toxin Regulations AGENCY: Animal and Plant Health Inspection Service, USDA... proposed rule that would amend and republish the list of select agents and toxins that have the potential...

  15. Federal and State Quarantine and Isolation Authority

    DTIC Science & Technology

    2006-08-16

    agents that are naturally occurring or released during a terrorist attack, the isolation of infected persons, and the quarantine of certain cities or...http://www.cdc.gov/ncidod/dq/sars_facts/isolationquarantine.pdf]. 9 42 U.S.C. § 264(e) and 42 C.F.R. § 70.2. agent from infecting others.5 The... agents ,” which include “anthrax, ebola, plague, smallpox, tularemia, or other bacterial, fungal, rickettsial, or viral agent , biological toxin, or other

  16. Combating terrorism : federal response teams provide varied capabilities; opportunities remain to improve coordination

    DOT National Transportation Integrated Search

    2000-01-01

    The General Accounting Office (GAO) was asked to review federal agency teams that can respond to and help manage the consequences of a domestic terrorist incident involving chemical, biological, radiological, or nuclear agents or weapons. This report...

  17. 45 CFR 303.69 - Requests by agents or attorneys of the United States for information from the Federal Parent...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... request information directly from the Federal PLS in connection with a parental kidnapping or child... locate an individual in connection with a parental kidnapping or child custody case. (2) Any information...

  18. 45 CFR 303.69 - Requests by agents or attorneys of the United States for information from the Federal Parent...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... request information directly from the Federal PLS in connection with a parental kidnapping or child... locate an individual in connection with a parental kidnapping or child custody case. (2) Any information...

  19. 45 CFR 303.69 - Requests by agents or attorneys of the United States for information from the Federal Parent...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... request information directly from the Federal PLS in connection with a parental kidnapping or child... locate an individual in connection with a parental kidnapping or child custody case. (2) Any information...

  20. 45 CFR 303.69 - Requests by agents or attorneys of the United States for information from the Federal Parent...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... request information directly from the Federal PLS in connection with a parental kidnapping or child... locate an individual in connection with a parental kidnapping or child custody case. (2) Any information...

  1. 48 CFR 36.602-1 - Selection criteria.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Selection criteria. 36.602-1 Section 36.602-1 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL... Selection criteria. (a) Agencies shall evaluate each potential contractor in terms of its— (1) Professional...

  2. The Real-Time ObjectAgent Software Architecture for Distributed Satellite Systems

    DTIC Science & Technology

    2001-01-01

    real - time operating system selection are also discussed. The fourth section describes a simple demonstration of real-time ObjectAgent. Finally, the...experience with C++. After selecting the programming language, it was necessary to select a target real - time operating system (RTOS) and embedded...ObjectAgent software to run on the OSE Real Time Operating System . In addition, she is responsible for the integration of ObjectAgent

  3. Opinions in Federated Search: University of Lugano at TREC 2014 Federated Web Search Track

    DTIC Science & Technology

    2014-11-01

    Opinions in Federated Search : University of Lugano at TREC 2014 Federated Web Search Track Anastasia Giachanou 1 , Ilya Markov 2 and Fabio Crestani 1...ranking based on sentiment using the retrieval-interpolated diversification method. Keywords: federated search , resource selection, vertical selection...performance. Federated search , also known as Distributed Information Retrieval (DIR), o↵ers the means of simultaneously searching multiple information

  4. Judge says leading viatical firm violated securities laws.

    PubMed

    1995-09-22

    A Federal judge has agreed with the Securities and Exchange Commission (SEC) in its suit against Life Partners, a leading viatical settlement company. According to the SEC, Life Partners buys insurance policies from persons living with AIDS in its own name and then sells interests in these policies to investors. The SEC alleges that these interests fall under the Federal securities laws. Life Partners contends that it acts solely as an agent on behalf of investors, and therefore securities laws do not apply. The judge's injunction requires Life Partners to transfer its insurance policies to an independent agent until the case is resolved.

  5. 47 CFR 68.418 - Procedure; designation of agents for service.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Procedure; designation of agents for service. 68.418 Section 68.418 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES (CONTINUED) CONNECTION OF TERMINAL EQUIPMENT TO THE TELEPHONE NETWORK Complaint Procedures § 68...

  6. 75 FR 1735 - Section 3504 Agent Employment Tax Liability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-13

    ...). SUPPLEMENTARY INFORMATION: Background Federal, State, and local government programs seek to help elderly or disabled individuals maintain their independence by funding home health care and other personal services... with employment tax compliance by helping the service recipients to designate agents to report, file...

  7. 47 CFR 14.35 - Procedure; designation of agents for service.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false Procedure; designation of agents for service. 14.35 Section 14.35 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL ACCESS TO ADVANCED COMMUNICATIONS SERVICES AND EQUIPMENT BY PEOPLE WITH DISABILITIES Recordkeeping, Consumer Dispute Assistance, and...

  8. 47 CFR 14.35 - Procedure; designation of agents for service.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false Procedure; designation of agents for service. 14.35 Section 14.35 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL ACCESS TO ADVANCED COMMUNICATIONS SERVICES AND EQUIPMENT BY PEOPLE WITH DISABILITIES Recordkeeping, Consumer Dispute Assistance, and...

  9. 47 CFR 14.35 - Procedure; designation of agents for service.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false Procedure; designation of agents for service. 14.35 Section 14.35 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL ACCESS TO ADVANCED COMMUNICATIONS SERVICES AND EQUIPMENT BY PEOPLE WITH DISABILITIES Recordkeeping, Consumer Dispute Assistance, and...

  10. Select Agent and Toxin Regulations: Beyond the Eighth Edition of the Guide for the Care and Use of Laboratory Animals

    PubMed Central

    Kastenmayer, Robin J; Moore, Rashida M; Bright, Allison L; Torres-Cruz, Rafael; Elkins, William R

    2012-01-01

    In the interval between the publication of the seventh and eighth editions of the Guide for the Care and Use of Laboratory Animals (Guide), much has changed with regard to the regulation and funding of highly pathogenic biologic agents and toxins (Select Agents). Funding of research involving highly pathogenic agents has increased dramatically during this time, thus increasing the demand for facilities capable of supporting this work. The eighth edition of the Guide briefly mentions Select Agents and provides a limited set of references. Here we provide some background information regarding the relevant laws and regulations, as well as an overview of the programmatic requirements pertaining to the use of Select Agents, with a focus on use in animals. PMID:22776191

  11. 9 CFR 121.3 - VS select agents and toxins.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... genetically modified. (d) VS select agents or toxins that meet any of the following criteria are excluded from... AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS POSSESSION, USE, AND... recombinant organisms: (1) Nucleic acids that can produce infectious forms of any of the select agent viruses...

  12. 42 CFR 73.4 - Overlap select agents and toxins.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES QUARANTINE, INSPECTION... its naturally occurring environment provided that the select agent or toxin has not been intentionally... such agent or toxin or destroys the agent or toxin by a recognized sterilization or inactivation...

  13. 48 CFR 15.101-2 - Lowest price technically acceptable source selection process.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Lowest price technically acceptable source selection process. 15.101-2 Section 15.101-2 Federal Acquisition Regulations System FEDERAL... Processes and Techniques 15.101-2 Lowest price technically acceptable source selection process. (a) The...

  14. 78 FR 63464 - William D. Ford Federal Direct Loan Program Repayment Plan Selection Form; Extension of Public...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-24

    ... DEPARTMENT OF EDUCATION William D. Ford Federal Direct Loan Program Repayment Plan Selection Form; Extension of Public Comment Period; Correction AGENCY: Department of Education. ACTION: Correction notice... entitled, ``William D. Ford Federal Direct Loan Program Repayment Plan Selection Form''. ED is extending...

  15. Impact of the Munitions Rule on management of military chemical warfare agents and associated waste

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kimmell, T.A.; Green, D.R.; Rosenblatt, D.H.

    1997-07-01

    The Federal Facility Compliance Act (FFCA), an amendment to the Resource Conservation and Recovery Act (RCRA), was signed by President Bush on October 6, 1992. Section 107 of the FFCA amended RCRA by adding a new Section 3004(y) that required the US Environmental Protection Agency (EPA) to develop, after consultation with the US Department of Defense (DOD) and appropriate state officials, regulations that identify when conventional and chemical munitions become hazardous waste and that provide for the safe transportation and storage of these wastes. The Military Munitions Rule (MMR) was proposed by EPA on November 8, 1995. The impact ofmore » the MMR on the management of military chemical warfare agents and associated waste is an important topic. There has been significant controversy regarding the disposition, under RCRA, of military chemical stockpile materials, and the MMR, in addition to issues with respect to conventional munitions, was expected to clarify the applicability of RCRA in these situations. The purpose of this paper is to review the applicability of the RCRA regulations to military chemical munitions that become waste and to discuss the impacts of the final MMR on the management of these wastes. The focus is on selected chemical agents that are part of the US chemical stockpile.« less

  16. 42 CFR 73.4 - Overlap select agents and toxins.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES QUARANTINE, INSPECTION... its naturally occurring environment provided that the select agent or toxin has not been intentionally... an entity eligible to receive such agent or toxin or destroys the agent or toxin by a recognized...

  17. Alpha-beta coordination method for collective search

    DOEpatents

    Goldsmith, Steven Y.

    2002-01-01

    The present invention comprises a decentralized coordination strategy called alpha-beta coordination. The alpha-beta coordination strategy is a family of collective search methods that allow teams of communicating agents to implicitly coordinate their search activities through a division of labor based on self-selected roles and self-determined status. An agent can play one of two complementary roles. An agent in the alpha role is motivated to improve its status by exploring new regions of the search space. An agent in the beta role is also motivated to improve its status, but is conservative and tends to remain aggregated with other agents until alpha agents have clearly identified and communicated better regions of the search space. An agent can select its role dynamically based on its current status value relative to the status values of neighboring team members. Status can be determined by a function of the agent's sensor readings, and can generally be a measurement of source intensity at the agent's current location. An agent's decision cycle can comprise three sequential decision rules: (1) selection of a current role based on the evaluation of the current status data, (2) selection of a specific subset of the current data, and (3) determination of the next heading using the selected data. Variations of the decision rules produce different versions of alpha and beta behaviors that lead to different collective behavior properties.

  18. 11 CFR 7.16 - Miscellaneous statutory provisions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 11 Federal Elections 1 2010-01-01 2010-01-01 false Miscellaneous statutory provisions. 7.16... bribery, graft, and conflicts of interest, as appropriate to the employees concerned. (b) The prohibition... employee acting as the agent of a foreign principal registered under the Foreign Agents Registration Act...

  19. 47 CFR 7.18 - Procedure; designation of agents for service.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Procedure; designation of agents for service. 7.18 Section 7.18 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL ACCESS TO VOICEMAIL AND INTERACTIVE MENU SERVICES AND EQUIPMENT BY PEOPLE WITH DISABILITIES Enforcement § 7.18 Procedure; designation...

  20. 20 CFR 404.1069 - Real estate agents and direct sellers.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Real estate agents and direct sellers. 404.1069 Section 404.1069 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND DISABILITY INSURANCE (1950- ) Employment, Wages, Self-Employment, and Self-Employment Income Self-Employment...

  1. 20 CFR 404.1069 - Real estate agents and direct sellers.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Real estate agents and direct sellers. 404.1069 Section 404.1069 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND DISABILITY INSURANCE (1950- ) Employment, Wages, Self-Employment, and Self-Employment Income Self-Employment...

  2. 20 CFR 404.1069 - Real estate agents and direct sellers.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Real estate agents and direct sellers. 404.1069 Section 404.1069 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND DISABILITY INSURANCE (1950- ) Employment, Wages, Self-Employment, and Self-Employment Income Self-Employment...

  3. 76 FR 58202 - TRICARE; TRICARE Sanction Authority for Third-Party Billing Agents

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-20

    ..., TRICARE Management Activity (TMA), or designee, with the authority to sanction third-party billing agents... instructions for submitting comments. Mail: Federal Docket Management System Office, 4800 Mark Center Drive.... Joy Saly, TRICARE Management Activity, Medical Benefits and Reimbursement Branch, telephone (303) 676...

  4. 5 CFR 843.207 - Agent of next of kin.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Agent of next of kin. 843.207 Section 843.207 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) FEDERAL EMPLOYEES RETIREMENT SYSTEM-DEATH BENEFITS AND EMPLOYEE REFUNDS One-time Payments § 843...

  5. 47 CFR 7.18 - Procedure; designation of agents for service.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false Procedure; designation of agents for service. 7.18 Section 7.18 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL ACCESS TO VOICEMAIL AND INTERACTIVE MENU SERVICES AND EQUIPMENT BY PEOPLE WITH DISABILITIES Enforcement § 7.18 Procedure; designation...

  6. 47 CFR 7.18 - Procedure; designation of agents for service.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false Procedure; designation of agents for service. 7.18 Section 7.18 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL ACCESS TO VOICEMAIL AND INTERACTIVE MENU SERVICES AND EQUIPMENT BY PEOPLE WITH DISABILITIES Enforcement § 7.18 Procedure; designation...

  7. 47 CFR 7.18 - Procedure; designation of agents for service.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false Procedure; designation of agents for service. 7.18 Section 7.18 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL ACCESS TO VOICEMAIL AND INTERACTIVE MENU SERVICES AND EQUIPMENT BY PEOPLE WITH DISABILITIES Enforcement § 7.18 Procedure; designation...

  8. 47 CFR 7.18 - Procedure; designation of agents for service.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false Procedure; designation of agents for service. 7.18 Section 7.18 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL ACCESS TO VOICEMAIL AND INTERACTIVE MENU SERVICES AND EQUIPMENT BY PEOPLE WITH DISABILITIES Enforcement § 7.18 Procedure; designation...

  9. 11 CFR 109.1 - When will this part apply?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Federal Elections FEDERAL ELECTION COMMISSION GENERAL COORDINATED AND INDEPENDENT EXPENDITURES (2 U.S.C... this part apply? This part applies to expenditures that are made independently from a candidate, an... coordination with a candidate, an authorized committee, a political party committee, or their agents. The rules...

  10. Fighting for Immigrant Children's Rights

    ERIC Educational Resources Information Center

    LaFee, Scott

    2007-01-01

    On the morning of Dec. 12, 2006, hundreds of federal agents from Immigration and Customs Enforcement descended upon six Swift and Co. meat-packing plants in Texas, Colorado, Nebraska, Iowa, Minnesota and Utah affecting communities. These federal crackdowns on illegal immigrants reverberate in schools too, forcing superintendents to confront some…

  11. 76 FR 74648 - Repeal of Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-01

    ... the manner of calculating the Resolution Funding Corporation (RefCorp) obligations of the Federal Home Loan Banks (Banks), respectively. FHFA is also repealing certain parts of the Office of Federal Housing... Banks and the Office of Finance (OF) (which acts as the Banks' fiscal agent) and certain functions of...

  12. 75 FR 63215 - Federal Salary Council Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-14

    ... Federal employee organizations and experts in the fields of labor relations and pay policy. The Council makes recommendations to the President's Pay Agent (the Secretary of Labor and the Directors of the Office of Management and Budget and the Office of Personnel Management) about the locality pay program...

  13. 78 FR 61404 - Federal Salary Council; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-03

    ... Federal employee organizations and experts in the fields of labor relations and pay policy. The Council makes recommendations to the President's Pay Agent (the Secretary of Labor and the Directors of the Office of Management and Budget and the Office of Personnel Management) about the locality pay program...

  14. 76 FR 59175 - Federal Salary Council; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-23

    ... Federal employee organizations and experts in the fields of labor relations and pay policy. The Council makes recommendations to the President's Pay Agent (the Secretary of Labor and the Directors of the Office of Management and Budget and the Office of Personnel Management) about the locality pay program...

  15. 7 CFR 331.10 - Restricting access to select agents and toxins; security risk assessments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...; security risk assessments. 331.10 Section 331.10 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE POSSESSION, USE, AND TRANSFER OF SELECT AGENTS AND TOXINS § 331.10 Restricting access to select agents and toxins; security risk...

  16. 42 CFR 73.5 - Exemptions for HHS select agents and toxins.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... the select agent or toxin is reported to CDC or APHIS and to other appropriate authorities when... followed by submission of APHIS/CDC Form 4 within seven calendar days after identification. (ii) For all other HHS select agents or toxins, APHIS/CDC Form 4 must be submitted within seven calendar days after...

  17. 42 CFR 73.5 - Exemptions for HHS select agents and toxins.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... the select agent or toxin is reported to CDC or APHIS and to other appropriate authorities when... followed by submission of APHIS/CDC Form 4 within seven calendar days after identification. (ii) For all other HHS select agents or toxins, APHIS/CDC Form 4 must be submitted within seven calendar days after...

  18. 9 CFR 121.6 - Exemptions for overlap select agents and toxins.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Exemptions for overlap select agents and toxins. 121.6 Section 121.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... select agent or toxin that is contained in a specimen presented for proficiency testing will be exempt...

  19. 9 CFR 121.6 - Exemptions for overlap select agents and toxins.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Exemptions for overlap select agents and toxins. 121.6 Section 121.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... select agent or toxin that is contained in a specimen presented for proficiency testing will be exempt...

  20. 48 CFR 36.301 - Use of two-phase design-build selection procedures.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Use of two-phase design-build selection procedures. 36.301 Section 36.301 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Two-Phase Design-Build Selection Procedures 36.301...

  1. Making Sense of Federal Employment and Training Policy for Youth and Adults. Volume II: Expert Recommendations To Create a Comprehensive and Unified System.

    ERIC Educational Resources Information Center

    Moore, Kristina M., Ed.; And Others

    This document contains 27 essays and 5 policy statements regarding creation of a comprehensive and unified federal employment and training policy for youth and adults. The following essays are included: "In Search of the American Way" (Wills); "Rethink the Demand Side" (Smith); "The Federal Government as a Change Agent" (Nathan); "Making Sense of…

  2. Department of Defense Federal Hazard Communication Training Program

    DTIC Science & Technology

    1988-04-01

    APPLICATION EXERCISE 3A-2 Continued Marilyn works as a supervisor in a plant that uses ammonium nitrate to make gun powder and blasting agents. 3) What...Dimethyl Freehold Products East Base Shop Polysiloxane Maintenance Shop Light Hydraulic Oil Texas Oil Co. Plant Maintenance C-2 Product Name Manufacturer Use ...Defense Federal Hazard Communication Training Program, Student Workbook," when used with "Department of Defense Federal Hazard Communication Training

  3. 31 CFR 332.6 - Purchase of bonds.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Purchase of bonds. 332.6 Section 332....6 Purchase of bonds. (a) Issuing agents. Only Federal Reserve Banks and Branches, as fiscal agents.... However, financial institutions were permitted to forward applications for purchase of the bonds to the...

  4. 13 CFR 114.108 - What if my claim is approved?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... agent or legal representative the forms necessary to indicate satisfaction of your claim and your acceptance of the payment. Acceptance by you, your agent or your legal representative of any award, compromise or settlement releases all your claims against the United States under the Federal Tort Claims Act...

  5. Aptitude and Language Learning of FBI Special Agents.

    ERIC Educational Resources Information Center

    Walker, Marijke; And Others

    This study investigated the relationship between aptitude, as measured by Defense Language Aptitude Battery (DLAB) scores, and oral proficiency as measured by the Oral Proficiency Interview (OPI) scores of 72 Federal Bureau of Investigation (FBI) Special Agents who completed basic foreign language training at the Defense Language Institute (DLI).…

  6. 20 CFR 429.203 - When is a claim allowable?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... of you, your agent, the members of your family, or your private employee (the standard to be applied... 429.203 Employees' Benefits SOCIAL SECURITY ADMINISTRATION ADMINISTRATIVE CLAIMS UNDER THE FEDERAL... travel under orders, including property in your custody or in the custody of a carrier, an agent or...

  7. 76 FR 38122 - Notice of Availability for Exclusive, Non-Exclusive, or Partially-Exclusive Licensing of an...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-29

    ... compounds have radical curative antimalarial activity. Brenda S. Bowen, Army Federal Register Liaison... Guanidylimidazoline Derivatives as Antimalarial Agents, Synthesis of and Methods of Use Thereof AGENCY: Department of... ``Guanidylimidazole and Guanidylimidazoline Derivatives as Antimalarial Agents, Synthesis of and Methods of Use...

  8. 31 CFR 330.9 - Fiscal agents.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Fiscal agents. 330.9 Section 330.9 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE.... Federal Reserve Bank of Kansas City, 925 Grand Avenue, Kansas City, MO 64198 Dallas, San Francisco, Kansas...

  9. 18 CFR 4.107 - Contents of application for exemption from licensing.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT LICENSES... 5 megawatts or less, from licensing under the Federal Power Act. [If applicable: The project is... each applicant are: (4) The exact name and business address of each person authorized to act as agent...

  10. 18 CFR 4.107 - Contents of application for exemption from licensing.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT LICENSES... 5 megawatts or less, from licensing under the Federal Power Act. [If applicable: The project is... each applicant are: (4) The exact name and business address of each person authorized to act as agent...

  11. 18 CFR 4.61 - Contents of application.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT LICENSES, PERMITS, EXEMPTIONS, AND DETERMINATION... each person authorized to act as agent for the applicant in this application, if applicable, are: (5... section 7(a) of the Federal Power Act. See 16 U.S.C. 796. (6)(i) The statutory or regulatory requirements...

  12. 18 CFR 4.61 - Contents of application.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT LICENSES, PERMITS, EXEMPTIONS, AND DETERMINATION... each person authorized to act as agent for the applicant in this application, if applicable, are: (5... section 7(a) of the Federal Power Act. See 16 U.S.C. 796. (6)(i) The statutory or regulatory requirements...

  13. 18 CFR 4.107 - Contents of application for exemption from licensing.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT LICENSES... 5 megawatts or less, from licensing under the Federal Power Act. [If applicable: The project is... each applicant are: (4) The exact name and business address of each person authorized to act as agent...

  14. 18 CFR 4.107 - Contents of application for exemption from licensing.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT LICENSES... 5 megawatts or less, from licensing under the Federal Power Act. [If applicable: The project is... each applicant are: (4) The exact name and business address of each person authorized to act as agent...

  15. 18 CFR 4.61 - Contents of application.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT LICENSES, PERMITS, EXEMPTIONS, AND DETERMINATION... each person authorized to act as agent for the applicant in this application, if applicable, are: (5... section 7(a) of the Federal Power Act. See 16 U.S.C. 796. (6)(i) The statutory or regulatory requirements...

  16. 18 CFR 4.107 - Contents of application for exemption from licensing.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT LICENSES... 5 megawatts or less, from licensing under the Federal Power Act. [If applicable: The project is... each applicant are: (4) The exact name and business address of each person authorized to act as agent...

  17. 18 CFR 4.61 - Contents of application.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT LICENSES, PERMITS, EXEMPTIONS, AND DETERMINATION... each person authorized to act as agent for the applicant in this application, if applicable, are: (5... section 7(a) of the Federal Power Act. See 16 U.S.C. 796. (6)(i) The statutory or regulatory requirements...

  18. 18 CFR 4.61 - Contents of application.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT LICENSES, PERMITS, EXEMPTIONS, AND DETERMINATION... each person authorized to act as agent for the applicant in this application, if applicable, are: (5... section 7(a) of the Federal Power Act. See 16 U.S.C. 796. (6)(i) The statutory or regulatory requirements...

  19. The New Federal Drinking Water Act: Implications of its Implementation for the College and University Campus

    ERIC Educational Resources Information Center

    Mohatt, James V.

    1977-01-01

    Institutional involvement under the Federal Safe Drinking Water Act (PL93-523) may range from zero cost to sizable expenditures depending upon whether the institution can be defined as a water supplier, or a cooperative agent of another water supplier. (MJB)

  20. 78 FR 26113 - Information Collection Renewal; Comment Request; Transfer Agent Registration and Amendment Form

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-03

    ... DEPARTMENT OF THE TREASURY Office of the Comptroller of the Currency FEDERAL DEPOSIT INSURANCE... AGENCIES: Office of the Comptroller of the Currency (OCC), Treasury; and Federal Deposit Insurance... Activities Division, Office of the Comptroller of the Currency, Attention: 1557-0124, 400 7th Street SW...

  1. 12 CFR 235.7 - Limitations on payment card restrictions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Section 235.7 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL... restrictions. (a) Prohibition on network exclusivity—(1) In general. An issuer or payment card network shall not directly or through any agent, processor, or licensed member of a payment card network, by...

  2. 12 CFR 235.7 - Limitations on payment card restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Section 235.7 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL... restrictions. (a) Prohibition on network exclusivity—(1) In general. An issuer or payment card network shall not directly or through any agent, processor, or licensed member of a payment card network, by...

  3. 12 CFR 235.7 - Limitations on payment card restrictions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Section 235.7 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL... restrictions. (a) Prohibition on network exclusivity—(1) In general. An issuer or payment card network shall not directly or through any agent, processor, or licensed member of a payment card network, by...

  4. Agent Reward Shaping for Alleviating Traffic Congestion

    NASA Technical Reports Server (NTRS)

    Tumer, Kagan; Agogino, Adrian

    2006-01-01

    Traffic congestion problems provide a unique environment to study how multi-agent systems promote desired system level behavior. What is particularly interesting in this class of problems is that no individual action is intrinsically "bad" for the system but that combinations of actions among agents lead to undesirable outcomes, As a consequence, agents need to learn how to coordinate their actions with those of other agents, rather than learn a particular set of "good" actions. This problem is ubiquitous in various traffic problems, including selecting departure times for commuters, routes for airlines, and paths for data routers. In this paper we present a multi-agent approach to two traffic problems, where far each driver, an agent selects the most suitable action using reinforcement learning. The agent rewards are based on concepts from collectives and aim to provide the agents with rewards that are both easy to learn and that if learned, lead to good system level behavior. In the first problem, we study how agents learn the best departure times of drivers in a daily commuting environment and how following those departure times alleviates congestion. In the second problem, we study how agents learn to select desirable routes to improve traffic flow and minimize delays for. all drivers.. In both sets of experiments,. agents using collective-based rewards produced near optimal performance (93-96% of optimal) whereas agents using system rewards (63-68%) barely outperformed random action selection (62-64%) and agents using local rewards (48-72%) performed worse than random in some instances.

  5. Influence of Selected Personal Characteristics and County Situational Factors on Time Allocated to Dairy Subjects by Extension Agents in Selected Tennessee Counties.

    ERIC Educational Resources Information Center

    Northcutt, Sherwin Dean; And Others

    The study deals with various predictors of time spent on dairy subjects by Extension agents and predictors of contacts made by agents with dairy clientele. Purposes were to determine the relationships, if any, between various independent variables and groups of independent variables (agents' background and training, county dairy situation, agents'…

  6. Isolation of potentially pathogenic fungi from selected pigeons' feeding sites in Karachi: A new dimension to health hazard.

    PubMed

    Naz, Sehar Afshan; Yaseen, Muhammad; Jabeen, Nusrat; Shafique, Maryam

    2017-06-01

    To determine the presence of pathogenic fungal strains in areas where pigeons are present in a large number. This study was conducted at the Federal Urdu University of Arts, Science and Technology, Karachi, from February 2015 to March2016, and comprised samples of soil contaminated with pigeons' excreta. The samples were collected from 20 different pigeon-feeding places in the city. These samples were processed for the isolation and identification of fungi by using standard conventional methods. The fungal strains isolated were also tested for their susceptibility to commonly used antifungal agents by disc diffusion technique. There were 105 samples. A wide variety of fungal strains belonging to different genera of Aspergillus, Rhizopus, Penicillium, Fusarium and Candida were isolated and identified by using conventional methods. The antifungal resistance pattern of these strains also depicts emergence of resistance against commonly used antifungal agents such as amphotericin B and fluconazole. The soil and air of places densely populated with pigeons were found to be loaded with fungal spores and many of them were potential pathogens.

  7. Microbubble Enzyme-Linked Immunosorbent Assay for the Detection of Targeted Microbubbles in in Vitro Static Binding Assays.

    PubMed

    Wischhusen, Jennifer; Padilla, Frederic

    2017-07-01

    Targeted microbubbles (MBs) are ultrasound contrast agents that are functionalized with a ligand for ultrasound molecular imaging of endothelial markers. Novel targeted MBs are characterized in vitro by incubation in protein-coated wells, followed by binding quantification by microscopy or ultrasound imaging. Both methods provide operator-dependent results: Between 3 and 20 fields of view from a heterogeneous sample are typically selected for analysis by microscopy, and in ultrasound imaging, different acoustic settings affect signal intensities. This study proposes a new method to reproducibly quantify MB binding based on enzyme-linked immunosorbent assay (ELISA), in which bound MBs are revealed with an enzyme-linked antibody. MB-ELISA was adapted to in vitro static binding assays, incubating the MBs in inverted position or by agitation, and compared with microscopy. The specificity and sensitivity of MB-ELISA enable the reliable quantification of MB binding in a rapid, high-throughput and whole-well analysis, facilitating the characterization of new targeted contrast agents. Copyright © 2017 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.

  8. 75 FR 42363 - Public Health Security and Bioterrorism Preparedness and Response Act of 2002; Biennial Review...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-21

    ... Bioterrorism Preparedness and Response Act of 2002; Biennial Review and Republication of the Select Agent and... Act) requires the biennial review and republication of the HHS list of select agents and toxins. Accordingly, we are soliciting public comment on the current HHS list of select agents and toxins, including...

  9. 75 FR 50730 - Public Health Security and Bioterrorism Preparedness and Response Act of 2002: Biennial Review...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-17

    ... Bioterrorism Preparedness and Response Act of 2002: Biennial Review and Republication of the Select Agent and... public comment on the current HHS list of select agents and toxins. This document is extending the... changes to the list of select agents and toxins'' and mailed to: Centers for Disease Control and...

  10. Contribution of Selective Conditions to Microbial Competition in Four Listeria Selective Enrichment Formulations

    PubMed Central

    Keys, Ashley L.; Hitchins, Anthony D.; Smiley, R. Derike

    2017-01-01

    Microbial competition during selective enrichment negatively affects Listeria monocytogenes populations and may hinder the subsequent detection or recovery of this organism. Competition assays among 10 selected strains of Listeria and Citrobacter braakii were performed in buffered Listeria enrichment broth, 3-(N-morpholino)propanesulfonic acid–buffered Listeria enrichment broth, University of Vermont medium–modified Listeria enrichment broth, and Fraser broth. The individual contributions of each selective agent in these media were also assessed, as well as the contribution of incubation temperature. Acriflavine hydrochloride and sodium nalidixate were ineffective at preventing the overgrowth of C. braakii; this resulted in substantially lower populations of Listeria than when the competitor was absent. At the higher levels, both of these selective agents were detrimental to Listeria populations. The highest enrichment populations of Listeria were observed when either NaCl or LiCl was present. In the absence of selective agents, the final populations of Listeria following competitive growth with C. braakii were not substantially affected by temperature; however, in the presence of selective agents, the Listeria populations were statistically higher at the higher incubation temperature. There are a limited number of selective agents available for use in Listeria-specific enrichment media, resulting in formulations that are only somewhat selective for this species. The optimization of current formulations may help researchers to improve Listeria recovery, particularly from products with a high microbial load. The understanding of the behavior and interactions between target and nontarget microorganisms in the presence of these available selective agents is a necessary step in the optimization of Listeria selective enrichment formulations. PMID:28221922

  11. Contribution of Selective Conditions to Microbial Competition in Four Listeria Selective Enrichment Formulations.

    PubMed

    Keys, Ashley L; Hitchins, Anthony D; Smiley, R Derike

    2016-11-01

    Microbial competition during selective enrichment negatively affects Listeria monocytogenes populations and may hinder the subsequent detection or recovery of this organism. Competition assays among 10 selected strains of Listeria and Citrobacter braakii were performed in buffered Listeria enrichment broth, 3-(N-morpholino)propanesulfonic acid-buffered Listeria enrichment broth, University of Vermont medium-modified Listeria enrichment broth, and Fraser broth. The individual contributions of each selective agent in these media were also assessed, as well as the contribution of incubation temperature. Acriflavine hydrochloride and sodium nalidixate were ineffective at preventing the overgrowth of C. braakii ; this resulted in substantially lower populations of Listeria than when the competitor was absent. At the higher levels, both of these selective agents were detrimental to Listeria populations. The highest enrichment populations of Listeria were observed when either NaCl or LiCl was present. In the absence of selective agents, the final populations of Listeria following competitive growth with C. braakii were not substantially affected by temperature; however, in the presence of selective agents, the Listeria populations were statistically higher at the higher incubation temperature. There are a limited number of selective agents available for use in Listeria -specific enrichment media, resulting in formulations that are only somewhat selective for this species. The optimization of current formulations may help researchers to improve Listeria recovery, particularly from products with a high microbial load. The understanding of the behavior and interactions between target and nontarget microorganisms in the presence of these available selective agents is a necessary step in the optimization of Listeria selective enrichment formulations.

  12. Review of Restricted Experiment Requests, Division of Select Agents and Toxins, Centers for Disease Control and Prevention, 2006-2013.

    PubMed

    Smith, Jacinta; Gangadharan, Denise; Weyant, Robbin

    2015-01-01

    The Centers for Disease Control and Prevention (CDC) Division of Select Agents and Toxins (DSAT) regulates laboratories that possess, use, or transfer select agents and toxins in the United States. DSAT also mitigates biosafety risks through the review of "restricted experiments," which under the select agent regulations are experiments that pose heightened biosafety risks. From January 2006 through December 2013, DSAT received 618 requests from 109 entities to perform potentially restricted experiments. Of these requests, 85% were determined not to meet the regulatory definition of a restricted experiment, while 15% of the requests met the definition of a restricted experiment. Of the 91 restricted experiments proposed, DSAT approved 31 (34%) requests because the biosafety conditions proposed were commensurate with the experiments' biosafety risk. All 31 approved restricted experiments were for work with select toxins. DSAT did not approve 60 restricted experiment requests due to potentially serious biosafety risks to public health and safety. All 60 denied restricted experiments proposed inserting drug resistance traits into select agents that could compromise the control of disease. The select agents and toxins associated most frequently with requests that met the regulatory definition of a restricted experiment are Shiga toxin (n = 16), Burkholderia mallei (n = 15), Botulinum neurotoxin (n = 14), and Brucella abortus (n = 14). In general, all restricted experiment decisions are determined on a case-by-case basis. This article describes the trends and characteristics of the data associated with restricted experiment requests among select agents that have an impact on public health and safety (HHS only agents) or both public health and safety and animal health or products (overlap agents). The information presented here, coupled with the information published in the restricted experiment guidance document ( www.selectagents.gov ), is intended to promote awareness among the research community of the type of experiments that meet the regulatory definition of a restricted experiment as well as to provide a greater understanding of the restricted experiment review process.

  13. Predicting the host range of Nystalea ebalea: secondary plant chemistry and host selection by a surrogate biological control agent of Schinus terebinthifolia

    USDA-ARS?s Scientific Manuscript database

    The safety of weed biological control depends upon the selection and utilization of the target weed by the agent while causing minimal harm to non-target species. Selection of weed species by biological control agents is determined by the presence of behavioral cues, generally host secondary plant c...

  14. A computer program for fast and easy typing of partial endoglucanase gene sequence into phylotypes and sequevars 1&2 (select agents) of Ralstonia solanacearum

    USDA-ARS?s Scientific Manuscript database

    The phytopathogen Ralstonia solanacearum is a species complex that contains a subset of strains that are quarantined or select agent pathogens. An unidentified R. solanacearum strain is considered a select agent in the US until proven otherwise, which can be done by phylogenetic analysis of a partia...

  15. Co-Selection of Resistance to Antibiotics, Biocides and Heavy Metals, and Its Relevance to Foodborne Pathogens

    PubMed Central

    Wales, Andrew D.; Davies, Robert H.

    2015-01-01

    Concerns have been raised in recent years regarding co-selection for antibiotic resistance among bacteria exposed to biocides used as disinfectants, antiseptics and preservatives, and to heavy metals (particularly copper and zinc) used as growth promoters and therapeutic agents for some livestock species. There is indeed experimental and observational evidence that exposure to these non-antibiotic antimicrobial agents can induce or select for bacterial adaptations that result in decreased susceptibility to one or more antibiotics. This may occur via cellular mechanisms that are protective across multiple classes of antimicrobial agents or by selection of genetic determinants for resistance to non-antibiotic agents that are linked to genes for antibiotic resistance. There may also be relevant effects of these antimicrobial agents on bacterial community structure and via non-specific mechanisms such as mobilization of genetic elements or mutagenesis. Notably, some co-selective adaptations have adverse effects on fitness in the absence of a continued selective pressure. The present review examines the evidence for the significance of these phenomena, particularly in respect of bacterial zoonotic agents that commonly occur in livestock and that may be transmitted, directly or via the food chain, to human populations. PMID:27025641

  16. Requirements for facilities transferring or receiving select agents. Final rule.

    PubMed

    2001-08-31

    CDC administers regulations that govern the transfer of certain biological agents and toxins ("select agents"). These regulations require entities that transfer or receive select agents to register with CDC and comply with biosafety standards contained in the Third Edition of the CDC/NIH publication "Biosafety in Microbiological and Biomedical Laboratories ("BMBL")." On October 28,1999, CDC published a Notice of Proposed Rulemaking ("NPRM") seeking both to revise the biosafety standards facilities must follow when handling select agents and to provide new biosecurity standards for such facilities. These new standards are contained in the Fourth Edition of BMBL, which the NPRM proposed to incorporate by reference, thereby replacing the Third Edition. No comments were received in response to this proposal. CDC is therefore amending its regulations to incorporate the Fourth Edition.

  17. 48 CFR 1336.602-4 - Selection authority.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Selection authority. 1336.602-4 Section 1336.602-4 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE SPECIAL...-4 Selection authority. Each contracting office shall designate the selection authority based on the...

  18. 76 FR 31306 - Admittance to Practice and Roster of Registered Patent Attorneys and Agents Admitted to Practice...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-31

    ... Patent Attorneys and Agents Admitted to Practice Before the United States Patent and Trademark Office... burden, invites the general public and other Federal agencies to take this opportunity to comment on the... William Griffin, Staff Attorney, Office of Enrollment and Discipline, United States Patent and Trademark...

  19. 76 FR 38122 - Notice of Availability for Exclusive, Non-Exclusive, or Partially-Exclusive Licensing of an...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-29

    ... curative antimalarial activity. Brenda S. Bowen, Army Federal Register Liaison Officer. [FR Doc. 2011-16258... Derivatives as Antimalarial Agents, Synthesis of and Methods of Use Thereof AGENCY: Department of the Army, Do...-Imidazoline Derivatives as Antimalarial Agents, Synthesis and Methods of Use Thereof,'' filed on April 26...

  20. 31 CFR 312.5 - Fiscal agents to serve without compensation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Fiscal agents to serve without compensation. 312.5 Section 312.5 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY BUREAU OF THE PUBLIC DEBT FEDERAL SAVINGS AND LOAN...

  1. 45 CFR 303.69 - Requests by agents or attorneys of the United States for information from the Federal Parent...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ENFORCEMENT PROGRAM), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... request information directly from the Federal PLS in connection with a parental kidnapping or child... locate an individual in connection with a parental kidnapping or child custody case. (2) Any information...

  2. 21 CFR 184.1095 - Sulfuric acid.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... from the National Academy Press, 2101 Constitution Ave. NW., Washington, DC 20418, or may be examined... this material at NARA, call 202-741-6030, or go to: http://www.archives.gov/federal_register/code_of_federal_regulations/ibr_locations.html. (c) The ingredient is used as a pH control agent as defined in...

  3. States as Change Agents under ESSA

    ERIC Educational Resources Information Center

    Weiss, Joanne; McGuinn, Patrick

    2016-01-01

    Under the Every Student Succeeds Act (ESSA), federal education mandates will be decreasing, which means states will have more flexibility and authority than they've had in decades. State education agency (SEA) leaders are confronting great change and great opportunity as many agencies move away from a focus on compliance with federal regulations,…

  4. Understanding Federal regulations as guidelines for classical biological control programs

    Treesearch

    Michael E. Montgomery

    2011-01-01

    This chapter reviews the legislation and rules that provide the foundation for federal regulation of the introduction of natural enemies of insects as biological control agents. It also outlines the steps for complying with regulatory requirements, using biological control of Adelges tsugae Annand, the hemlock woolly adelgid (HWA), as an example. The...

  5. 39 CFR 761.1 - Definition of terms.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... or indicates: (a) Reserve Bank means the Federal Reserve Bank of New York (and any other Federal Reserve Bank which agrees to issue Postal Service securities in book-entry form) as fiscal agent of the... in these regulations on the records of a Reserve Bank. (e) Pledge includes a pledge of, or any other...

  6. 48 CFR 1436.602-4 - Selection authority.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Selection authority. 1436.602-4 Section 1436.602-4 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR SPECIAL...-4 Selection authority. The HCA is authorized to serve as the designated selection authority. ...

  7. 48 CFR 2936.602-4 - Selection Authority.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Selection Authority. 2936.602-4 Section 2936.602-4 Federal Acquisition Regulations System DEPARTMENT OF LABOR GENERAL... Selection Authority. The HCA is authorized to serve as the designated Selection Authority in accordance with...

  8. Consultant selection guidebook : procedures for selecting consultants for FHWA federal-aid projects and state funded projects. [Rev. 2002

    DOT National Transportation Integrated Search

    2002-01-01

    This Guidebook provides an overview of procedures for consultant selection. The local agencies that intend to request federal and state funds for reimbursement of consultant services should follow specific selection and contracting procedures. These ...

  9. Implementation of Multi-Agent Object Attention System Based on Biologically Inspired Attractor Selection

    NASA Astrophysics Data System (ADS)

    Hashimoto, Ryoji; Matsumura, Tomoya; Nozato, Yoshihiro; Watanabe, Kenji; Onoye, Takao

    A multi-agent object attention system is proposed, which is based on biologically inspired attractor selection model. Object attention is facilitated by using a video sequence and a depth map obtained through a compound-eye image sensor TOMBO. Robustness of the multi-agent system over environmental changes is enhanced by utilizing the biological model of adaptive response by attractor selection. To implement the proposed system, an efficient VLSI architecture is employed with reducing enormous computational costs and memory accesses required for depth map processing and multi-agent attractor selection process. According to the FPGA implementation result of the proposed object attention system, which is accomplished by using 7,063 slices, 640×512 pixel input images can be processed in real-time with three agents at a rate of 9fps in 48MHz operation.

  10. Federated Search Tools in Fusion Centers: Bridging Databases in the Information Sharing Environment

    DTIC Science & Technology

    2012-09-01

    considerable variation in how fusion centers plan for, gather requirements, select and acquire federated search tools to bridge disparate databases...centers, when considering integrating federated search tools; by evaluating the importance of the planning, requirements gathering, selection and...acquisition processes for integrating federated search tools; by acknowledging the challenges faced by some fusion centers during these integration processes

  11. TANDEM: A Trust-Based Agent Framework for Networked Decision Making

    DTIC Science & Technology

    2015-09-10

    selective (20–80 %), while the rest are good citizens, trust acts as a method to isolate misbehaving agents. If the majority of the agents have high...competence and low selectivity, then they can use trust to isolate route information around the misbehaving agents, improving Comm and Steps. The impact is...more dramatic when only 20–40 % of the agents are misbehaving . However, using trust results in reduced SA as the information available at the

  12. 48 CFR 2436.602-4 - Selection authority.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Selection authority. 2436.602-4 Section 2436.602-4 Federal Acquisition Regulations System DEPARTMENT OF HOUSING AND URBAN... Services 2436.602-4 Selection authority. (a) The final selection decision shall be made by the cognizant...

  13. Peptide-based protein capture agents with high affinity, selectivity, and stability as antibody replacements in biodetection assays

    NASA Astrophysics Data System (ADS)

    Coppock, Matthew B.; Farrow, Blake; Warner, Candice; Finch, Amethist S.; Lai, Bert; Sarkes, Deborah A.; Heath, James R.; Stratis-Cullum, Dimitra

    2014-05-01

    Current biodetection assays that employ monoclonal antibodies as primary capture agents exhibit limited fieldability, shelf life, and performance due to batch-to-batch production variability and restricted thermal stability. In order to improve upon the detection of biological threats in fieldable assays and systems for the Army, we are investigating protein catalyzed capture (PCC) agents as drop-in replacements for the existing antibody technology through iterative in situ click chemistry. The PCC agent oligopeptides are developed against known protein epitopes and can be mass produced using robotic methods. In this work, a PCC agent under development will be discussed. The performance, including affinity, selectivity, and stability of the capture agent technology, is analyzed by immunoprecipitation, western blotting, and ELISA experiments. The oligopeptide demonstrates superb selectivity coupled with high affinity through multi-ligand design, and improved thermal, chemical, and biochemical stability due to non-natural amino acid PCC agent design.

  14. 48 CFR 1301.603-2 - Selection.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Selection. 1301.603-2 Section 1301.603-2 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE GENERAL DEPARTMENT OF... 1301.603-2 Selection. In addition to the criteria set forth in FAR 1.603-2, selection of contracting...

  15. [Bolivian hemorrhagic fever].

    PubMed

    Markin, V A; Pantiukhov, V B; Markov, V I; Bondarev, V P

    2013-01-01

    Analysis of data of the available literature on epidemiology of Bolivian hemorrhagic fever, manifestations of human disease, biological properties of the causative agent and development carried out abroad of means and methods of diagnostics, prophylaxis and therapy of this infection that presents a potential threat for the population and economy of the Russian Federation in case of introduction of the causative agent is presented.

  16. 77 FR 71178 - Meeting of the Uniform Formulary Beneficiary Advisory Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-29

    ... Class Reviews (Comments will follow each agenda item) a. Hepatitis C Agents b. Overactive Bladder Agents...: Notice of meeting. SUMMARY: Under the provisions of the Federal Advisory Committee Act of 1972 (5 U.S.C. Appendix, as amended) and the Government in the Sunshine Act of 1976 (5 U.S.C. 552b, as amended) the...

  17. 17 CFR 249b.101 - Form TA-W, notice of withdrawal from registration as transfer agent.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Form TA-W, notice of... TA-W, notice of withdrawal from registration as transfer agent. This form shall be used for...))) [42 FR 44984, Sept. 8, 1977] Editorial Note: For Federal Register citations affecting Form TA-W, see...

  18. 16 CFR 1025.70 - General provisions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Flammable Fabrics Act (15 U.S.C. 1192, 1197(b)), and section 15 of the Federal Hazardous Substances Act (15... based on rates customarily charged by persons engaged in the business of acting as attorneys, agents and... applicant. (2) No award for the fee of an attorney or agent under these rules may exceed $75 per hour. No...

  19. 16 CFR § 1025.70 - General provisions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Flammable Fabrics Act (15 U.S.C. 1192, 1197(b)), and section 15 of the Federal Hazardous Substances Act (15... based on rates customarily charged by persons engaged in the business of acting as attorneys, agents and... applicant. (2) No award for the fee of an attorney or agent under these rules may exceed $75 per hour. No...

  20. 16 CFR 1025.70 - General provisions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Flammable Fabrics Act (15 U.S.C. 1192, 1197(b)), and section 15 of the Federal Hazardous Substances Act (15... based on rates customarily charged by persons engaged in the business of acting as attorneys, agents and... applicant. (2) No award for the fee of an attorney or agent under these rules may exceed $75 per hour. No...

  1. Reflective Thinking and Emotional Intelligence as Predictive Performance Factors in Problem-Based Learning Situations

    ERIC Educational Resources Information Center

    Mitchell-White, Kathleen

    2010-01-01

    Continued improvement of the training and preparation of Federal Bureau of Investigation (FBI) special agents is critical to the organization's ability to protect the national security of the United States. Too little attention has been paid to the factors that improve new agent trainees' (NATs) ability to learn and succeed in their training…

  2. 12 CFR 330.7 - Accounts held by an agent, nominee, guardian, custodian or conservator.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Accounts held by an agent, nominee, guardian, custodian or conservator. 330.7 Section 330.7 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION.... Funds held by a guardian, custodian, or conservator for the benefit of his or her ward, or for the...

  3. 76 FR 21805 - User Fees Relating to Enrolled Agents and Enrolled Retirement Plan Agents

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-19

    ... 44 U.S.C. 1510. #0; #0;The Code of Federal Regulations is sold by the Superintendent of Documents. #0...(d). FOR FURTHER INFORMATION CONTACT: Concerning the final regulations, Emily M. Lesniak at (202) 622... Offices Appropriations Act of 1952, which is codified at 31 U.S.C. 9701, authorizes agencies to prescribe...

  4. 21 CFR 1005.25 - Service of process on manufacturers.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Subchapter C—Electronic Product Radiation Control of the Federal Food, Drug, and Cosmetic Act (formerly the Radiation Control for Health and Safety Act of 1968) (21 U.S.C. 360mm(d)) and this section. The agent may be... Radiation Control of the Federal Food, Drug, and Cosmetic Act (formerly the Radiation Control for Health and...

  5. 21 CFR 1005.25 - Service of process on manufacturers.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Subchapter C—Electronic Product Radiation Control of the Federal Food, Drug, and Cosmetic Act (formerly the Radiation Control for Health and Safety Act of 1968) (21 U.S.C. 360mm(d)) and this section. The agent may be... Subchapter C—Electronic Product Radiation Control of the Federal Food, Drug, and Cosmetic Act (formerly the...

  6. 21 CFR 1005.25 - Service of process on manufacturers.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Subchapter C—Electronic Product Radiation Control of the Federal Food, Drug, and Cosmetic Act (formerly the Radiation Control for Health and Safety Act of 1968) (21 U.S.C. 360mm(d)) and this section. The agent may be... Radiation Control of the Federal Food, Drug, and Cosmetic Act (formerly the Radiation Control for Health and...

  7. 21 CFR 1005.25 - Service of process on manufacturers.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Subchapter C—Electronic Product Radiation Control of the Federal Food, Drug, and Cosmetic Act (formerly the Radiation Control for Health and Safety Act of 1968) (21 U.S.C. 360mm(d)) and this section. The agent may be... Subchapter C—Electronic Product Radiation Control of the Federal Food, Drug, and Cosmetic Act (formerly the...

  8. Supports for Community-Based Mental Health Care: An Optimistic Review of Federal Legislation.

    ERIC Educational Resources Information Center

    Bentley, Kia J.

    1994-01-01

    Describes and summarizes recent relevant federal legislative initiatives and analyzes their potential in providing support for community-based mental health care for adults in United States. Contends that these legislative mandates and options can be source of optimism and ammunition for advocates and change agents as they work to improve mental…

  9. San Diego State U. Defends Its Role in Federal Drug Sting

    ERIC Educational Resources Information Center

    Lipka, Sara

    2008-01-01

    When a freshman at San Diego State University (SDSU) died of a cocaine overdose last May, the campus police chief decided to pursue a full-scale investigation. In December, he summoned undercover agents from the federal Drug Enforcement Administration to pose as students and roam the campus in search of illegal drugs. According to college…

  10. School Principals as Agents of Reform of the Russian Education System

    ERIC Educational Resources Information Center

    Kasprzhak, A. G.; Filinov, N. B.; Bayburin, R. F.; Isaeva, N. V.; Bysik, N. V.

    2015-01-01

    The paper is based on the results of a study of secondary school principal decision-making styles conducted in eight regions of the Russian Federation (one per federal district) in 2014 using the methodological approach developed by Alan J. Rowe. The study aimed to assess the reformist potential of Russian school principals. We believe that this…

  11. Biosafety Oversight and Compliance: What do you Mean, I have to Fill Out Another Form?!

    PubMed

    Petrella, Brenda L

    2015-11-03

    This unit is an overview of biosafety compliance and oversight in the United States. Specific attention is given to the oversight of the Institutional Biosafety Committee (IBC) and how the purview of the IBC may overlap with other local committees, such as the Institutional Animal Care and Use Committee (IACUC) for animal research and the Institutional Review Board (IRB) for research on human subjects. Requirements for the Federal Select Agent Program and Dual Use Research of Concern (DURC) are also briefly reviewed for those working with materials and experiments covered under these regulations. This unit serves as a guide for new and established investigators who are navigating the regulatory world and how regulatory oversight applies to their research. Copyright © 2015 John Wiley & Sons, Inc.

  12. Prospective Investigation of Injury Rates and Injury Risk Factors Among Federal Bureau of Investigation New Agent Trainees, Quantico, Virginia, 2009-2010

    DTIC Science & Technology

    2010-08-01

    assistance of the United States Army Public Health Command (USAPHC) in injury prevention efforts at the FBI New Agent Training Program at the FBI...personnel to apply their experience in injury prevention programs in military training to assist in injury prevention efforts in the FBI New Agent... prevention recommendations USAPHC had made Army-wide. USAPHC personnel proposed a methodology to evaluate injury incidence and injury risk factors

  13. Review of Restricted Experiment Requests, Division of Select Agents and Toxins, Centers for Disease Control and Prevention, 2006-2013

    PubMed Central

    Smith, Jacinta; Weyant, Robbin

    2015-01-01

    The Centers for Disease Control and Prevention (CDC) Division of Select Agents and Toxins (DSAT) regulates laboratories that possess, use, or transfer select agents and toxins in the United States. DSAT also mitigates biosafety risks through the review of “restricted experiments,” which under the select agent regulations are experiments that pose heightened biosafety risks. From January 2006 through December 2013, DSAT received 618 requests from 109 entities to perform potentially restricted experiments. Of these requests, 85% were determined not to meet the regulatory definition of a restricted experiment, while 15% of the requests met the definition of a restricted experiment. Of the 91 restricted experiments proposed, DSAT approved 31 (34%) requests because the biosafety conditions proposed were commensurate with the experiments' biosafety risk. All 31 approved restricted experiments were for work with select toxins. DSAT did not approve 60 restricted experiment requests due to potentially serious biosafety risks to public health and safety. All 60 denied restricted experiments proposed inserting drug resistance traits into select agents that could compromise the control of disease. The select agents and toxins associated most frequently with requests that met the regulatory definition of a restricted experiment are Shiga toxin (n = 16), Burkholderia mallei (n = 15), Botulinum neurotoxin (n = 14), and Brucella abortus (n = 14). In general, all restricted experiment decisions are determined on a case-by-case basis. This article describes the trends and characteristics of the data associated with restricted experiment requests among select agents that have an impact on public health and safety (HHS only agents) or both public health and safety and animal health or products (overlap agents). The information presented here, coupled with the information published in the restricted experiment guidance document (www.selectagents.gov), is intended to promote awareness among the research community of the type of experiments that meet the regulatory definition of a restricted experiment as well as to provide a greater understanding of the restricted experiment review process. PMID:26347984

  14. Study of Federal technology transfer activities in areas of interest to NASA Office of Space and Terrestrial Applications

    NASA Technical Reports Server (NTRS)

    Madigan, J. A.; Earhart, R. W.

    1978-01-01

    Forty-three ongoing technology transfer programs in Federal agencies other than NASA were selected from over 200 current Federal technology transfer activities. Selection was made and specific technology transfer mechanisms utilized. Detailed information was obtained on the selected programs by reviewing published literature, and conducting telephone interviews with each program manager. Specific information collected on each program includes technology areas; user groups, mechanisms employed, duration of program, and level of effort. Twenty-four distinct mechanisms are currently employed in Federal technology transfer activities totaling $260 million per year. Typical applications of each mechanism were reviewed, and caveats on evaluating program effectiveness were discussed. A review of recent federally funded research in technology transfer to state and local governments was made utilizing the Smithsonian Science Information Exchange, and abstracts of interest to NASA were selected for further reference.

  15. Design Principles of Nanoparticles as Contrast Agents for Magnetic Resonance Imaging

    NASA Astrophysics Data System (ADS)

    Shan, Liang; Gu, Xinbin; Wang, Paul

    2013-09-01

    Molecular imaging is an emerging field that introduces molecular agents into traditional imaging techniques, enabling visualization, characterization and measurement of biological processes at the molecular and cellular levels in humans and other living systems. The promise of molecular imaging lies in its potential for selective potency by targeting biomarkers or molecular targets and the imaging agents serve as reporters for the selectivity of targeting. Development of an efficient molecular imaging agent depends on well-controlled high-quality experiment design involving target selection, agent synthesis, in vitro characterization, and in vivo animal characterization before it is applied in humans. According to the analysis from the Molecular Imaging and Contrast Agent Database (MICAD, ), more than 6000 molecular imaging agents with sufficient preclinical evaluation have been reported to date in the literature and this number increases by 250-300 novel agents each year. The majority of these agents are radionuclides, which are developed for positron emission tomography (PET) and single photon emission computed tomography (SPECT). Contrast agents for magnetic resonance imaging (MRI) account for only a small part. This is largely due to the fact that MRI is currently not a fully quantitative imaging technique and is less sensitive than PET and SPECT. However, because of the superior ability to simultaneously extract molecular and anatomic information, molecular MRI is attracting significant interest and various targeted nanoparticle contrast agents have been synthesized for MRI. The first and one of the most critical steps in developing a targeted nanoparticle contrast agent is target selection, which plays the central role and forms the basis for success of molecular imaging. This chapter discusses the design principles of targeted contrast agents in the emerging frontiers of molecular MRI.

  16. Adaptive consensus of scale-free multi-agent system by randomly selecting links

    NASA Astrophysics Data System (ADS)

    Mou, Jinping; Ge, Huafeng

    2016-06-01

    This paper investigates an adaptive consensus problem for distributed scale-free multi-agent systems (SFMASs) by randomly selecting links, where the degree of each node follows a power-law distribution. The randomly selecting links are based on the assumption that every agent decides to select links among its neighbours according to the received data with a certain probability. Accordingly, a novel consensus protocol with the range of the received data is developed, and each node updates its state according to the protocol. By the iterative method and Cauchy inequality, the theoretical analysis shows that all errors among agents converge to zero, and in the meanwhile, several criteria of consensus are obtained. One numerical example shows the reliability of the proposed methods.

  17. Marine Science Affairs--Selecting Priority Programs.

    ERIC Educational Resources Information Center

    National Council on Marine Resources and Engineering Development, Washington, DC.

    This report summarizes accomplishments in 1969, describing Federal programs and policies, and new programs implemented to meet those policies. The report describes the priorities that have been selected in the Federal Marine Science program during 1969. The first chapter reviews the steps taken by the Federal Government during 1969 to advance and…

  18. 75 FR 72777 - Defense Federal Acquisition Regulation Supplement; Patents, Data, and Copyrights (DFARS Case 2010...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-26

    ... RIN 0750-AG62 Defense Federal Acquisition Regulation Supplement; Patents, Data, and Copyrights (DFARS... Defense Federal Acquisition Regulation Supplement (DFARS) to update text on patents, data, and copyrights... selecting ``Search.'' Select the link ``Submit a Comment'' that corresponds with ``DFARS Case 2010-D001...

  19. 48 CFR 715.370 - Alternative source selection procedures.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Alternative source selection procedures. 715.370 Section 715.370 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection 715...

  20. Microbial Resistance to Triclosan: A Case Study in Natural Selection

    ERIC Educational Resources Information Center

    Serafini, Amanda; Matthews, Dorothy M.

    2009-01-01

    Natural selection is the mechanism of evolution caused by the environmental selection of organisms most fit to reproduce, sometimes explained as "survival of the fittest." An example of evolution by natural selection is the development of bacteria that are resistant to antimicrobial agents as a result of exposure to these agents. Triclosan, which…

  1. 48 CFR 236.602-1 - Selection criteria.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Selection criteria. 236.602-1 Section 236.602-1 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM... Architect-Engineer Services 236.602-1 Selection criteria. (a) Establish the evaluation criteria before...

  2. Fluorination utilizing thermodynamically unstable fluorides and fluoride salts thereof

    DOEpatents

    Bartlett, Neil; Whalen, J. Marc; Chacon, Lisa

    2000-12-12

    A method for fluorinating a carbon compound or cationic carbon compound utilizes a fluorination agent selected from thermodynamically unstable nickel fluorides and salts thereof in liquid anhydrous hydrogen fluoride. The desired carbon compound or cationic organic compound to undergo fluorination is selected and reacted with the fluorination agent by contacting the selected organic or cationic organic compound and the chosen fluorination agent in a reaction vessel for a desired reaction time period at room temperature or less.

  3. 75 FR 54496 - Diseases Associated With Exposure to Certain Herbicide Agents (Hairy Cell Leukemia and Other...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-08

    ... Certain Herbicide Agents (Hairy Cell Leukemia and Other Chronic B-Cell Leukemias, Parkinson's Disease and..., VA published in the Federal Register (75 FR 53202), an amendment to 38 CFR 3.309 to add hairy cell leukemia and other chronic B-cell leukemias, Parkinson's disease and ischemic heart disease to the list of...

  4. Interoperability, Data Control and Battlespace Visualization using XML, XSLT and X3D

    DTIC Science & Technology

    2003-09-01

    26 Rosenthal, Arnon, Seligman , Len and Costello, Roger, XML, Databases, and Interoperability, Federal Database Colloquium, AFCEA, San Diego...79 Rosenthal, Arnon, Seligman , Len and Costello, Roger, “XML, Databases, and Interoperability”, Federal Database Colloquium, AFCEA, San Diego, 1999... Linda , Mastering XML, Premium Edition, SYBEX, 2001 Wooldridge, Michael , An Introduction to MultiAgent Systems, Wiley, 2002 PAPERS Abernathy, M

  5. 12 CFR Appendix A to Part 22 - Sample Form of Notice of Special Flood Hazards and Availability of Federal Disaster Relief...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... property securing the loan is located participates in the National Flood Insurance Program (NFIP). Federal... for you at your expense. • Flood insurance coverage under the NFIP may be purchased through an insurance agent who will obtain the policy either directly through the NFIP or through an insurance company...

  6. 12 CFR Appendix A to Part 22 - Sample Form of Notice of Special Flood Hazards and Availability of Federal Disaster Relief...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... property securing the loan is located participates in the National Flood Insurance Program (NFIP). Federal... for you at your expense. • Flood insurance coverage under the NFIP may be purchased through an insurance agent who will obtain the policy either directly through the NFIP or through an insurance company...

  7. 12 CFR Appendix A to Part 172 - Sample Form of Notice of Special Flood Hazards and Availability of Federal Disaster Relief...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... property securing the loan is located participates in the National Flood Insurance Program (NFIP). Federal... for you at your expense. • Flood insurance coverage under the NFIP may be purchased through an insurance agent who will obtain the policy either directly through the NFIP or through an insurance company...

  8. 12 CFR Appendix A to Part 572 - Sample Form of Notice of Special Flood Hazards and Availability of Federal Disaster Relief...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... property securing the loan is located participates in the National Flood Insurance Program (NFIP). Federal... for you at your expense. • Flood insurance coverage under the NFIP may be purchased through an insurance agent who will obtain the policy either directly through the NFIP or through an insurance company...

  9. 38 CFR Appendix A to Part 36 - Sample Form of Notice of Special Flood Hazards and Availability of Federal Disaster Relief...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... property securing the loan is located participates in the National Flood Insurance Program (NFIP). Federal... for you at your expense. • Flood insurance coverage under the NFIP may be purchased through an insurance agent who will obtain the policy either directly through the NFIP or through an insurance company...

  10. 38 CFR Appendix A to Part 36 - Sample Form of Notice of Special Flood Hazards and Availability of Federal Disaster Relief...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... property securing the loan is located participates in the National Flood Insurance Program (NFIP). Federal... for you at your expense. • Flood insurance coverage under the NFIP may be purchased through an insurance agent who will obtain the policy either directly through the NFIP or through an insurance company...

  11. 12 CFR Appendix A to Part 572 - Sample Form of Notice of Special Flood Hazards and Availability of Federal Disaster Relief...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... property securing the loan is located participates in the National Flood Insurance Program (NFIP). Federal... for you at your expense. • Flood insurance coverage under the NFIP may be purchased through an insurance agent who will obtain the policy either directly through the NFIP or through an insurance company...

  12. 12 CFR Appendix A to Part 172 - Sample Form of Notice of Special Flood Hazards and Availability of Federal Disaster Relief...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... property securing the loan is located participates in the National Flood Insurance Program (NFIP). Federal... for you at your expense. • Flood insurance coverage under the NFIP may be purchased through an insurance agent who will obtain the policy either directly through the NFIP or through an insurance company...

  13. 12 CFR Appendix A to Part 172 - Sample Form of Notice of Special Flood Hazards and Availability of Federal Disaster Relief...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... property securing the loan is located participates in the National Flood Insurance Program (NFIP). Federal... for you at your expense. • Flood insurance coverage under the NFIP may be purchased through an insurance agent who will obtain the policy either directly through the NFIP or through an insurance company...

  14. 38 CFR Appendix A to Part 36 - Sample Form of Notice of Special Flood Hazards and Availability of Federal Disaster Relief...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... property securing the loan is located participates in the National Flood Insurance Program (NFIP). Federal... for you at your expense. • Flood insurance coverage under the NFIP may be purchased through an insurance agent who will obtain the policy either directly through the NFIP or through an insurance company...

  15. 12 CFR Appendix A to Part 22 - Sample Form of Notice of Special Flood Hazards and Availability of Federal Disaster Relief...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... property securing the loan is located participates in the National Flood Insurance Program (NFIP). Federal... for you at your expense. • Flood insurance coverage under the NFIP may be purchased through an insurance agent who will obtain the policy either directly through the NFIP or through an insurance company...

  16. 12 CFR Appendix A to Part 572 - Sample Form of Notice of Special Flood Hazards and Availability of Federal Disaster Relief...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... property securing the loan is located participates in the National Flood Insurance Program (NFIP). Federal... for you at your expense. • Flood insurance coverage under the NFIP may be purchased through an insurance agent who will obtain the policy either directly through the NFIP or through an insurance company...

  17. 12 CFR 811.2 - Scope and effect of book-entry procedure.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 7 2013-01-01 2013-01-01 false Scope and effect of book-entry procedure. 811.2 Section 811.2 Banks and Banking FEDERAL FINANCING BANK BOOK-ENTRY PROCEDURE FOR FEDERAL FINANCING BANK SECURITIES § 811.2 Scope and effect of book-entry procedure. (a) A Reserve Bank, as fiscal agent of the...

  18. 12 CFR 811.2 - Scope and effect of book-entry procedure.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 7 2014-01-01 2014-01-01 false Scope and effect of book-entry procedure. 811.2 Section 811.2 Banks and Banking FEDERAL FINANCING BANK BOOK-ENTRY PROCEDURE FOR FEDERAL FINANCING BANK SECURITIES § 811.2 Scope and effect of book-entry procedure. (a) A Reserve Bank, as fiscal agent of the...

  19. 12 CFR 811.2 - Scope and effect of book-entry procedure.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 7 2012-01-01 2012-01-01 false Scope and effect of book-entry procedure. 811.2 Section 811.2 Banks and Banking FEDERAL FINANCING BANK BOOK-ENTRY PROCEDURE FOR FEDERAL FINANCING BANK SECURITIES § 811.2 Scope and effect of book-entry procedure. (a) A Reserve Bank, as fiscal agent of the...

  20. 12 CFR 811.2 - Scope and effect of book-entry procedure.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Scope and effect of book-entry procedure. 811.2 Section 811.2 Banks and Banking FEDERAL FINANCING BANK BOOK-ENTRY PROCEDURE FOR FEDERAL FINANCING BANK SECURITIES § 811.2 Scope and effect of book-entry procedure. (a) A Reserve Bank, as fiscal agent of the...

  1. 12 CFR 811.2 - Scope and effect of book-entry procedure.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Scope and effect of book-entry procedure. 811.2 Section 811.2 Banks and Banking FEDERAL FINANCING BANK BOOK-ENTRY PROCEDURE FOR FEDERAL FINANCING BANK SECURITIES § 811.2 Scope and effect of book-entry procedure. (a) A Reserve Bank, as fiscal agent of the...

  2. Acquired Immune Deficiency Syndrome, AIDS: A Selected Bibliography of Federal Government Publications. Research Guide 90 104.

    ERIC Educational Resources Information Center

    Alexander, Margaret

    This research guide presents a selected bibliography of federal government publications about the Acquired Immune Deficiency Syndrome (AIDS). These documents are listed in five categories: (1) Bibliographies (7); (2) Congressional Publications (69 hearings and reports); (3) Executive Branch Publications (43 reports); (4) Federal Government…

  3. 75 FR 44724 - Agricultural Bioterrorism Protection Act of 2002; Biennial Review and Republication of the Select...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-29

    ... Bioterrorism Protection Act of 2002; Biennial Review and Republication of the Select Agent and Toxin List; Reorganization of the Select Agent and Toxin List AGENCY: Animal and Plant Health Inspection Service, USDA... Agricultural Bioterrorism Protection Act of 2002, we are soliciting public comment regarding the list of select...

  4. 48 CFR 2415.308 - Source selection decision.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Source selection decision. 2415.308 Section 2415.308 Federal Acquisition Regulations System DEPARTMENT OF HOUSING AND URBAN... document its selection recommendation(s) in a final written report. The final report shall include...

  5. Pollinator-mediated natural selection in Penstemon digitalis.

    PubMed

    Parachnowitsch, Amy; Kessler, André

    2010-12-01

    Measuring the agents of natural selection is important because it allows us to understand not only which traits are expected to evolve but also why they will evolve. Natural selection by pollinators on floral traits is often assumed because in outcrossing animal-pollinated plants flowers are generally thought to function as advertisements of rewards directed at pollinators. We tested the role of bee pollinators in selection on Penstemon digitalis and found that pollinators were driving selection for larger and more flowers. However, what makes our publication unique is the additional information we gained from reviewing the few other studies that also directly tested whether pollinators were agents of selection on floral traits. As we would expect if pollinators are important agents of selection, selection on floral traits was significantly stronger when pollinators were present than when they were experimentally removed. Taken together, these results suggest that pollinators can be important drivers of selection in contemporary populations.

  6. Exposure levels for chemical threat compounds: information to facilitate chemical incident response.

    PubMed

    Hauschild, Veronique D; Watson, Annetta

    2013-01-01

    Although not widely known, a robust set of peer-reviewed public health and occupational exposure levels presently exist for key chemical warfare agents (CWAs) and certain acutely toxic industrial chemicals (TICs) identified as terrorist attack threats. Familiarity with these CWA and TIC exposure levels and their historic applications has facilitated emergency management decision-making by public and environmental health decision-makers. Specifically, multiple air, soil, and water exposure levels for CWAs and TICs summarized here have been extensively peer-reviewed and published; many have been recognized and are in use by federal and state health agencies as criteria for hazard zone prediction and assessment, occupational safety, and "how clean is clean enough" decisions. The key, however, is to know which criteria are most appropriate for specific decisions. While public safety is critical, high levels of concern often associated with perceived or actual proximity to extremely toxic chemical agents could result in overly cautious decisions that generate excessive delays, expenditure of scarce resources, and technological difficulties. Rapid selection of the most appropriate chemical exposure criteria is recommended to avoid such problems and expedite all phases of chemical incident response and recovery.

  7. Implementation of a personnel reliability program as a facilitator of biosafety and biosecurity culture in BSL-3 and BSL-4 laboratories.

    PubMed

    Higgins, Jacki J; Weaver, Patrick; Fitch, J Patrick; Johnson, Barbara; Pearl, R Marene

    2013-06-01

    In late 2010, the National Biodefense Analysis and Countermeasures Center (NBACC) implemented a Personnel Reliability Program (PRP) with the goal of enabling active participation by its staff to drive and improve the biosafety and biosecurity culture at the organization. A philosophical keystone for accomplishment of NBACC's scientific mission is simultaneous excellence in operations and outreach. Its personnel reliability program builds on this approach to: (1) enable and support a culture of responsibility based on human performance principles, (2) maintain compliance with regulations, and (3) address the risk associated with the insider threat. Recently, the Code of Federal Regulations (CFR) governing use and possession of biological select agents and toxins (BSAT) was amended to require a pre-access suitability assessment and ongoing evaluation for staff accessing Tier 1 BSAT. These 2 new requirements are in addition to the already required Federal Bureau of Investigation (FBI) Security Risk Assessment (SRA). Two years prior to the release of these guidelines, NBACC developed its PRP to supplement the SRA requirement as a means to empower personnel and foster an operational environment where any and all work with BSAT is conducted in a safe, secure, and reliable manner.

  8. Method for photo-altering a biological system to improve biological effect

    DOEpatents

    Hill, Richard A.; Doiron, Daniel R.; Crean, David H.

    2000-08-01

    Photodynamic therapy is a new adjunctive therapy for filtration surgery that does not use chemotherapy agents or radiation, but uses pharmacologically-active sensitizing compounds to produce a titratable, localized, transient, post operative avascular conjunctiva. A photosensitizing agent in a biological system is selectively activated by delivering the photosensitive agent to the biological system and laser activating only a spatially selected portion of the delivered photosensitive agent. The activated portion of the photosensitive agent reacts with the biological system to obtain a predetermined biological effect. As a result, an improved spatial disposition and effectuation of the biological effect by the photosensitive agent in the biological system is achieved.

  9. Selective Targeting of Antiviral and Immunomodulating Agents in the Treatment of Arenavirus Infections

    DTIC Science & Technology

    1987-10-01

    observed with free MTP-PE. In addition to our observations on peritoneal and alveolar macrophages, we also examined the effect of MTP-PE treatment on liver...Ir OIC FILE COPY C2 ILn 00 NM AD _____ N SELECTIVE TARGETING OF ANTIVIRAL AND IMMUNOMODULATING AGENTS IN THE TREATMENT OF ARENAVIRUS INFECTIONS "Kc...Selective Targeting of Antiviral and Immunomodulating Agents in the Treatment of Arenavirus Injections 12. PERSONAL AUTHOR(S) J. David Gangemi 13a. TYPE OF

  10. 48 CFR 1401.603-2 - Selection.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Selection. 1401.603-2 Section 1401.603-2 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR GENERAL DEPARTMENT OF... Responsibilities 1401.603-2 Selection. COs, regardless of series or organizational placement, must be certified at...

  11. 48 CFR 1436.602-1 - Selection criteria.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Selection criteria. 1436.602-1 Section 1436.602-1 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR SPECIAL...-1 Selection criteria. (a) The CO may include specific evaluation criteria to be used in the...

  12. 48 CFR 2936.602-1 - Selection criteria.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Selection criteria. 2936.602-1 Section 2936.602-1 Federal Acquisition Regulations System DEPARTMENT OF LABOR GENERAL... Selection criteria. HCAs are authorized to approve the use of design competition under the conditions in FAR...

  13. 48 CFR 436.602-1 - Selection criteria.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Selection criteria. 436.602-1 Section 436.602-1 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE SPECIAL... Selection criteria. The HCA is authorized to approve the use of design competition under the conditions in...

  14. 48 CFR 636.602-1 - Selection criteria.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Selection criteria. 636.602-1 Section 636.602-1 Federal Acquisition Regulations System DEPARTMENT OF STATE SPECIAL CATEGORIES... Selection criteria. (b) The head of the contracting activity is the agency head's designee for the purpose...

  15. 48 CFR 236.602 - Selection of firms for architect-engineer contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Selection of firms for architect-engineer contracts. 236.602 Section 236.602 Federal Acquisition Regulations System DEFENSE... ARCHITECT-ENGINEER CONTRACTS Architect-Engineer Services 236.602 Selection of firms for architect-engineer...

  16. 48 CFR 236.602 - Selection of firms for architect-engineer contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Selection of firms for architect-engineer contracts. 236.602 Section 236.602 Federal Acquisition Regulations System DEFENSE... ARCHITECT-ENGINEER CONTRACTS Architect-Engineer Services 236.602 Selection of firms for architect-engineer...

  17. 48 CFR 236.602 - Selection of firms for architect-engineer contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Selection of firms for architect-engineer contracts. 236.602 Section 236.602 Federal Acquisition Regulations System DEFENSE... ARCHITECT-ENGINEER CONTRACTS Architect-Engineer Services 236.602 Selection of firms for architect-engineer...

  18. 48 CFR 236.602 - Selection of firms for architect-engineer contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Selection of firms for architect-engineer contracts. 236.602 Section 236.602 Federal Acquisition Regulations System DEFENSE... ARCHITECT-ENGINEER CONTRACTS Architect-Engineer Services 236.602 Selection of firms for architect-engineer...

  19. 48 CFR 236.602 - Selection of firms for architect-engineer contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Selection of firms for architect-engineer contracts. 236.602 Section 236.602 Federal Acquisition Regulations System DEFENSE... ARCHITECT-ENGINEER CONTRACTS Architect-Engineer Services 236.602 Selection of firms for architect-engineer...

  20. 9 CFR 121.5 - Exemptions for VS select agents and toxins.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Exemptions for VS select agents and toxins. 121.5 Section 121.5 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... agent or toxin that is contained in a specimen presented for proficiency testing will be exempt from the...

  1. 9 CFR 121.6 - Exemptions for overlap select agents and toxins.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Exemptions for overlap select agents and toxins. 121.6 Section 121.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... presented for proficiency testing will be exempt from the requirements of this part for such agent or toxin...

  2. 9 CFR 121.6 - Exemptions for overlap select agents and toxins.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Exemptions for overlap select agents and toxins. 121.6 Section 121.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... presented for proficiency testing will be exempt from the requirements of this part for such agent or toxin...

  3. 9 CFR 121.5 - Exemptions for VS select agents and toxins.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Exemptions for VS select agents and toxins. 121.5 Section 121.5 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... agent or toxin that is contained in a specimen presented for proficiency testing will be exempt from the...

  4. 9 CFR 121.5 - Exemptions for VS select agents and toxins.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Exemptions for VS select agents and toxins. 121.5 Section 121.5 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... agent or toxin that is contained in a specimen presented for proficiency testing will be exempt from the...

  5. 9 CFR 121.6 - Exemptions for overlap select agents and toxins.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Exemptions for overlap select agents and toxins. 121.6 Section 121.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... presented for proficiency testing will be exempt from the requirements of this part for such agent or toxin...

  6. 75 FR 76397 - Effectiveness of Federal Agency Participation in Standardization in Select Technology Sectors for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-08

    ... innovation in the technology sector(s) that is the subject of your comment? What is the current phase of the...-02] Effectiveness of Federal Agency Participation in Standardization in Select Technology Sectors for... private sector, the Sub-Committee on Standards intends to develop information on how Federal agencies may...

  7. 78 FR 15920 - Federal Motor Vehicle Safety Standards; Tire Selection and Rims

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-13

    ... [Docket No. NHTSA-2013-0030] RIN 2127-AL24 Federal Motor Vehicle Safety Standards; Tire Selection and Rims...: Notice of proposed rulemaking (NPRM). SUMMARY: This document proposes to amend Federal Motor Vehicle... installed on new trailers with a gross vehicle weight rating (GVWR) of 4,536 kg (10,000 lbs.) or less. It...

  8. 48 CFR 36.602-5 - Short selection process for contracts not to exceed the simplified acquisition threshold.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Short selection process for contracts not to exceed the simplified acquisition threshold. 36.602-5 Section 36.602-5 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS...

  9. 48 CFR 36.602-5 - Short selection process for contracts not to exceed the simplified acquisition threshold.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Short selection process for contracts not to exceed the simplified acquisition threshold. 36.602-5 Section 36.602-5 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS...

  10. 48 CFR 36.602-5 - Short selection process for contracts not to exceed the simplified acquisition threshold.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Short selection process for contracts not to exceed the simplified acquisition threshold. 36.602-5 Section 36.602-5 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS...

  11. 48 CFR 36.602-5 - Short selection process for contracts not to exceed the simplified acquisition threshold.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Short selection process for contracts not to exceed the simplified acquisition threshold. 36.602-5 Section 36.602-5 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS...

  12. 48 CFR 36.602-5 - Short selection process for contracts not to exceed the simplified acquisition threshold.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Short selection process for contracts not to exceed the simplified acquisition threshold. 36.602-5 Section 36.602-5 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS...

  13. 7 CFR 331.3 - PPQ select agents and toxins.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...) Select agents and toxins listed in paragraph (b) of this section that have been genetically modified. (d... variegated chlorosis strain). (c) Genetic elements, recombinant nucleic acids, and recombinant organisms: (1...

  14. 42 CFR 73.4 - Overlap select agents and toxins.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... genetically modified. (d) Overlap select agents or toxins that meet any of the following criteria are excluded... Equine Encephalitis virus (c) Genetic Elements, Recombinant Nucleic Acids, and Recombinant Organisms: (1...

  15. 7 CFR 331.3 - PPQ select agents and toxins.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...) Select agents and toxins listed in paragraph (b) of this section that have been genetically modified. (d... variegated chlorosis strain). (c) Genetic elements, recombinant nucleic acids, and recombinant organisms: (1...

  16. National Center for the Training of Educational Resource Agents to Serve Rural Minorities. The Preparation of Problem Solving/Development/Diffusion Personnel to Serve Rural/Minority/Culturally Limited Populations.

    ERIC Educational Resources Information Center

    Tuskegee Inst., AL.

    A blueprint for Educational Resource Agents (ERA's) has been compiled by a consortium consisting of the National Federation for the Improvement of Rural Education, Tuskegee Institute, New Mexico State University, University of North Dakota, Northwest Regional Educational Lab., Southwestern Cooperative Educational Lab., Appalachia Educational Lab.,…

  17. NIE Final Report. Vermont Special Purpose Grant, January 1979 through September 1979 [and] Evaluation of the Resource Agent Program.

    ERIC Educational Resources Information Center

    Perry, Mary; Miller, Pamela A.

    Vermont's adaptation of a federal Resource Agent Program (RAP), designed to meet the in-service training needs of teachers, is described in this final report. Part of a complete dissemination system, RAP was funded as a pilot program to initiate a collection of Vermont-originated resources to be entered into a state educational database. Described…

  18. Thermal inactivation of infested plants, nursery equipment, and soil is a management option for the treatment of Phytophthora ramorum, causal agent of sudden oak death

    Treesearch

    Wolfgang Schweigkofler; Vernon Huffman; Karen Suslow; Kathleen Kosta

    2017-01-01

    Infected nursery plants play an important role in the spread of Phytophthora ramorum , the causal agent of sudden oak death and ramorum blight. In order to minimize the risk for disease transmission to new areas, nurseries are inspected regularly for P. ramorum , and federal regulations require the eradication of...

  19. 2 CFR 180.615 - How does a Federal agency notify a person of a suspension or debarment action?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false How does a Federal agency notify a person of a suspension or debarment action? 180.615 Section 180.615 Grants and Agreements OFFICE OF MANAGEMENT..., or e-mail address of— (1) You or your identified counsel; or (2) Your agent for service of process...

  20. Employer-provided health insurance and hospital mergers.

    PubMed

    Garmon, Christopher

    2013-07-01

    This paper explores the impact of employer-provided health insurance on hospital competition and hospital mergers. Under employer-provided health insurance, employer executives act as agents for their employees in selecting health insurance options for their firm. The paper investigates whether a merger of hospitals favored by executives will result in a larger price increase than a merger of competing hospitals elsewhere. This is found to be the case even when the executive has the same opportunity cost of travel as her employees and even when the executive is the sole owner of the firm, retaining all profits. This is consistent with the Federal Trade Commission's findings in its challenge of Evanston Northwestern Healthcare's acquisition of Highland Park Hospital. Implications of the model are further tested with executive location data and hospital data from Florida and Texas.

  1. 42 CFR 455.100 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... the Social Security Act. It sets forth State plan requirements regarding— (a) Disclosure by providers... Federal financial participation for services furnished by providers or fiscal agents who fail to comply...

  2. 49 CFR 392.1 - Scope of the rules in this part.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS DRIVING OF..., agents, representatives, and employees responsible for the management, maintenance, operation, or driving...

  3. The role of genetic background in susceptibility to chemical warfare nerve agents across rodent and non-human primate models.

    PubMed

    Matson, Liana M; McCarren, Hilary S; Cadieux, C Linn; Cerasoli, Douglas M; McDonough, John H

    2018-01-15

    Genetics likely play a role in various responses to nerve agent exposure, as genetic background plays an important role in behavioral, neurological, and physiological responses to environmental stimuli. Mouse strains or selected lines can be used to identify susceptibility based on background genetic features to nerve agent exposure. Additional genetic techniques can then be used to identify mechanisms underlying resistance and sensitivity, with the ultimate goal of developing more effective and targeted therapies. Here, we discuss the available literature on strain and selected line differences in cholinesterase activity levels and response to nerve agent-induced toxicity and seizures. We also discuss the available cholinesterase and toxicity literature across different non-human primate species. The available data suggest that robust genetic differences exist in cholinesterase activity, nerve agent-induced toxicity, and chemical-induced seizures. Available cholinesterase data suggest that acetylcholinesterase activity differs across strains, but are limited by the paucity of carboxylesterase data in strains and selected lines. Toxicity and seizures, two outcomes of nerve agent exposure, have not been fully evaluated for genetic differences, and thus further studies are required to understand baseline strain and selected line differences. Published by Elsevier B.V.

  4. Federal Support to Universities, Colleges, and Selected Nonprofit Institutions, Fiscal Year 1977. A Report to the President and Congress. Surveys of Science Resources Series.

    ERIC Educational Resources Information Center

    Huckenpahler, J. G.; Bennof, Richard J.

    Data collected in the National Science Foundation's Survey of Federal Support to Universities, Colleges, and Selected Nonprofit Institutions, descriptive analysis are presented. Federal support to universities and colleges is designated by: type of activity (research and development, R&D plant, nonscience activities); funding agency; geographic…

  5. 7 CFR 331.3 - PPQ select agents and toxins.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... (b) of this section that have been genetically modified. (d) Select agents or toxins that meet any of..., and recombinant and/or synthetic organisms: (1) Nucleic acids that can produce infectious forms of any...

  6. 7 CFR 331.3 - PPQ select agents and toxins.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... (b) of this section that have been genetically modified. (d) Select agents or toxins that meet any of..., and recombinant and/or synthetic organisms: (1) Nucleic acids that can produce infectious forms of any...

  7. 24 CFR 180.220 - Separation of functions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... AND BUSINESS OPPORTUNITY CONSOLIDATED HUD HEARING PROCEDURES FOR CIVIL RIGHTS MATTERS Administrative Law Judge § 180.220 Separation of functions. No officer, employee, or agent of the Federal Government...

  8. 22 CFR 64.2 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... group of governments and an official agent or representative thereof; an international organization... household of a Federal employee means a relative of the employee by blood, marriage, or adoption or any...

  9. The New Agent: A Qualitative Study to Strategically Adapt New Agent Professional Development

    ERIC Educational Resources Information Center

    Baker, Lauri M.; Hadley, Gregg

    2014-01-01

    The qualitative study reported here assessed the needs of agents related to new agent professional development to improve the current model. Agents who participated in new agent professional development within the last 5 years were selected to participate in focus groups to determine concerns and continued needs. Agents enjoyed networking and…

  10. Burnout among Extension Agents in the Ohio Cooperative Extension Service.

    ERIC Educational Resources Information Center

    Igodan, O. Chris; Newcomb, L. H.

    A study examined the extent and causes of burnout among extension agents in Ohio. From the 241 extension agents working in the 88 counties of Ohio, researchers selected a random sample of 101 agents. Included in the sample were 34 agriculture agents, 33 home economics agents. Included in the sample agents were asked to complete a survey…

  11. Synergy of irofulven in combination with other DNA damaging agents: synergistic interaction with altretamine, alkylating, and platinum-derived agents in the MV522 lung tumor model.

    PubMed

    Kelner, Michael J; McMorris, Trevor C; Rojas, Rafael J; Estes, Leita A; Suthipinijtham, Pharnuk

    2008-12-01

    Irofulven (MGI 114, NSC 683863) is a semisynthetic derivative of illudin S, a natural product present in the Omphalotus illudins (Jack O'Lantern) mushroom. This novel agent produces DNA damage, that in contrast to other agents, is predominately ignored by the global genome repair pathway of the nucleotide excision repair (NER)(2) system. The aim of this study was to determine the antitumor activity of irofulven when administered in combination with 44 different DNA damaging agents, whose damage is in general detected and repaired by the genome repair pathway. The human lung carcinoma MV522 cell line and its corresponding xenograft model were used to evaluate the activity of irofulven in combination with different DNA damaging agents. Two main classes of DNA damaging agents, platinum-derived agents, and select bifunctional alkylating agents, demonstrated in vivo synergistic or super-additive interaction with irofulven. DNA helicase inhibiting agents also demonstrated synergy in vitro, but an enhanced interaction with irofulven could not be demonstrated in vivo. There was no detectable synergistic activity between irofulven and agents capable of inducing DNA cleavage or intercalating into DNA. These results indicate that the antitumor activity of irofulven is enhanced when combined with platinum-derived agents, altretamine, and select alkylating agents such as melphalan or chlorambucil. A common factor between these agents appears to be the production of intrastrand DNA crosslinks. The synergistic interaction between irofulven and other agents may stem from the nucleotide excision repair system being selectively overwhelmed at two distinct points in the pathway, resulting in prolonged stalling of transcription forks, and subsequent initiation of apoptosis.

  12. 76 FR 12118 - Proposed Data Collections Submitted for Public Comment and Recommendations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-04

    ... that come to CDC for Select Agents. The term select agents is used to describe a limited group of... bioterrorism, inflicting significant morbidity and mortality on susceptible populations. In light of current...

  13. Guidelines for Contracting Microfilming Services.

    ERIC Educational Resources Information Center

    Byrne, Sherry

    1986-01-01

    Outlines the process involved in selecting an outside filming agent for the purpose of preserving a library's or archive's holdings. Guidelines include project planning, selecting a filming agent, and contract preparation and maintenance. A sample contract is included. (Author/EM)

  14. 76 FR 4896 - Call for Candidates

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-27

    ... designated to establish generally accepted accounting principles for federal government entities. Generally, non-federal Board members are selected from the general financial community, the accounting and... FEDERAL ACCOUNTING STANDARDS ADVISORY BOARD Call for Candidates AGENCY: Federal Accounting...

  15. An Expression of Periodic Phenomena of Fashion on Sexual Selection Model with Conformity Genes and Memes

    NASA Astrophysics Data System (ADS)

    Mutoh, Atsuko; Tokuhara, Shinya; Kanoh, Masayoshi; Oboshi, Tamon; Kato, Shohei; Itoh, Hidenori

    It is generally thought that living things have trends in their preferences. The mechanism of occurrence of another trends in successive periods is concerned in their conformity. According to social impact theory, the minority is always exists in the group. There is a possibility that the minority make the transition to the majority by conforming agents. Because of agent's promotion of their conform actions, the majority can make the transition. We proposed an evolutionary model with both genes and memes, and elucidated the interaction between genes and memes on sexual selection. In this paper, we propose an agent model for sexual selection imported the concept of conformity. Using this model we try an environment where male agents and female agents are existed, we find that periodic phenomena of fashion are expressed. And we report the influence of conformity and differentiation on the transition of their preferences.

  16. 12 CFR Appendix to Part 760 - Sample Form of Notice of Special Flood Hazards and Availability of Federal Disaster Relief...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Program (NFIP). Federal law will not allow us to make you the loan that you have applied for if you do not... flood insurance for you at your expense. • Flood insurance coverage under the NFIP may be purchased through an insurance agent who will obtain the policy either directly through the NFIP or through an...

  17. 12 CFR Appendix to Part 760 - Sample Form of Notice of Special Flood Hazards and Availability of Federal Disaster Relief...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Program (NFIP). Federal law will not allow us to make you the loan that you have applied for if you do not... flood insurance for you at your expense. • Flood insurance coverage under the NFIP may be purchased through an insurance agent who will obtain the policy either directly through the NFIP or through an...

  18. 12 CFR Appendix to Subpart D of... - Sample Form of Notice of Special Flood Hazards and Availability of Federal Disaster Relief...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Program (NFIP). Federal law will not allow us to make you the loan that you have applied for if you do not... flood insurance for you at your expense. • Flood insurance coverage under the NFIP may be purchased through an insurance agent who will obtain the policy either directly through the NFIP or through an...

  19. 12 CFR Appendix to Subpart D of... - Sample Form of Notice of Special Flood Hazards and Availability of Federal Disaster Relief...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Program (NFIP). Federal law will not allow us to make you the loan that you have applied for if you do not... flood insurance for you at your expense. • Flood insurance coverage under the NFIP may be purchased through an insurance agent who will obtain the policy either directly through the NFIP or through an...

  20. 12 CFR Appendix to Part 760 - Sample Form of Notice of Special Flood Hazards and Availability of Federal Disaster Relief...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Program (NFIP). Federal law will not allow us to make you the loan that you have applied for if you do not... flood insurance for you at your expense. • Flood insurance coverage under the NFIP may be purchased through an insurance agent who will obtain the policy either directly through the NFIP or through an...

  1. Community College Agreement between the Alaska Community Colleges' Federation of Teachers Local 2404, AFT, and the University of Alaska, April 1, 1984-March 31, 1987.

    ERIC Educational Resources Information Center

    Alaska Univ., Fairbanks.

    The collective bargaining agreement between the University of Alaska and the Alaska Community Colleges' Federation of Teachers, the exclusive bargaining agent for all statewide rural education learning center and community college faculty, is presented, covering the period between April 1, 1984 and March 31, 1987. The 13 articles in the agreement…

  2. Federal Support to Universities, Colleges, and Selected Nonprofit Institutions, Fiscal Year 1971. A Report to the President and Congress.

    ERIC Educational Resources Information Center

    Loycano, Robert J.; Sale, Suzanne

    This report is the latest in a series of annual reports to the President and Congress on total Federal obligations (excluding loans) awarded to individual institutions of higher education and selected nonprofit institutions. A major portion of the report focuses on Federal obligations to universities and colleges for research and development, R &…

  3. Federal Support to Universities, Colleges, and Selected Nonprofit Institutions, Fiscal Year 1980. A Report to the President and Congress. Final Report. Surveys of Science Resources Series.

    ERIC Educational Resources Information Center

    Bennof, Richard J.

    Data are presented from the National Science Foundation's Survey of Federal Support to Universities, Colleges, and Selected Nonprofit Institutions, Fiscal Year 1980. The data represent all obligations to U.S. institutions of higher education. The 15 federal agencies represented account for an estimated 95 percent of total obligations to…

  4. Hydrocarbon extraction agents and microbiological processes for their production

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zajic, J.E.; Gerson, D.F.

    1987-02-03

    A process is described for producing extraction agents useful in the separation of hydrocarbon values from mineral deposits. It comprises cultivating by an aerobic fermentation, in a growth promoting medium and under growth promoting conditions, and on a liquid hydrocarbon substrate, a selected microbial strain of a species of microorganism selected from the group consisting of Arthrobacter terregens, Arthrobacter xerosis, Bacillus megaterium, Corynebacterium lepus, Corynebacterium xerosis, Nocardia petroleophila, and Vibrio ficheri. This is done to produce an extraction agent of microbiological origin in the fermentation medium, subsequently recovering the extraction agent from the fermentation medium and drying the agent tomore » powdered form.« less

  5. Mechanisms and dynamics of cooperation and competition emergence in complex networked systems

    NASA Astrophysics Data System (ADS)

    Gianetto, David A.

    Cooperative behavior is a pervasive phenomenon in human interactions and yet how it can evolve and become established, through the selfish process of natural selection, is an enduring puzzle. These behaviors emerge when agents interact in a structured manner; even so, the key structural factors that affect cooperation are not well understood. Moreover, the literature often considers cooperation a single attribute of primitive agents who do not react to environmental changes but real-world actors are more perceptive. The present work moves beyond these assumptions by evolving more realistic game participants, with memories of the past, on complex networks. Agents play repeated games with a three-part Markovian strategy that allows us to separate the cooperation phenomenon into trust, reciprocity, and forgiveness characteristics. Our results show that networks matter most when agents gain the most by acting in a selfish manner, irrespective of how much they may lose by cooperating; since the context provided by neighborhoods inhibits greedy impulses that agents otherwise succumb to in isolation. Network modularity is the most important driver of cooperation emergence in these high-stakes games. However, modularity fails to tell the complete story. Modular scale-free graphs impede cooperation when close coordination is required, partially due to the acyclic nature of scale-free network models. To achieve the highest cooperation in diverse social conditions, both high modularity, low connectivity within modules, and a rich network of long cycles become important. With these findings in hand, we study the influence of networks on coordination and competition within the federal health care insurance exchange. In this applied study, we show that systemic health care coordination is encouraged by the emergent insurance network. The network helps underpin the viability of the exchange and provides an environment of stronger competition once a critical-mass of insurers have entered the market.

  6. Collagenase Santyl ointment: a selective agent for wound debridement.

    PubMed

    Shi, Lei; Carson, Dennis

    2009-01-01

    Enzymatic debridement is a frequently used technique for removal of necrotic tissue from wounds. Proteases with specificity to break down the collagenous materials in necrotic tissues can achieve selective debridement, digesting denatured collagen in eschar while sparing nonnecrotic tissues. This article provides information about the selectivity of a collagenase-based debriding agent, including evidence of its safe and efficacious uses. Recent research has been conducted, investigating the chemical and biological properties of collagenase ointment, including healing in animal models, digestion power on different collagen types, cell migration activity from collagen degradation products, and compatibility with various wound dressings and metal ions. Evidence presented demonstrates that collagenase ointment is an effective, selective, and safe wound debriding agent.

  7. 42 CFR 73.10 - Restricting access to select agents and toxins; security risk assessments.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... AND HUMAN SERVICES QUARANTINE, INSPECTION, LICENSING SELECT AGENTS AND TOXINS § 73.10 Restricting... or intelligence agency of committing a crime specified in 18 U.S.C. 2332b(g)(5), knowing involvement...

  8. Oligo-branched peptides for tumor targeting: from magic bullets to magic forks.

    PubMed

    Falciani, Chiara; Pini, Alessandro; Bracci, Luisa

    2009-02-01

    Selective targeting of tumor cells is the final goal of research and drug discovery for cancer diagnosis, imaging and therapy. After the invention of hybridoma technology, the concept of magic bullet was introduced into the field of oncology, referring to selective killing of tumor cells, by specific antibodies. More recently, small molecules and peptides have also been proposed as selective targeting agents. We analyze the state of the art of tumor-selective agents that are presently available and tested in clinical settings. A novel approach based on 'armed' oligo-branched peptides as tumor targeting agents, is discussed and compared with existing tumor-selective therapies mediated by antibodies, small molecules or monomeric peptides. Oligo-branched peptides could be novel drugs that combine the advantages of antibodies and small molecules.

  9. 40 Code of Federal Regulations (CFR) 300.900 - 920

    EPA Pesticide Factsheets

    Data requirements for this subpart J of the National Contingency Plan Product Schedule. Products include dispersants, bioremediation agents, or any other chemical authorized to remove or control oil discharges.

  10. 31 CFR 224.2 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.2 Definitions. For purposes of this regulation: (a) Principal means the person or entity required to provide a...

  11. 48 CFR 36.602 - Selection of firms for architect-engineer contracts.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... architect-engineer contracts. 36.602 Section 36.602 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Architect-Engineer Services 36.602 Selection of firms for architect-engineer contracts. ...

  12. 48 CFR 36.602 - Selection of firms for architect-engineer contracts.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... architect-engineer contracts. 36.602 Section 36.602 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Architect-Engineer Services 36.602 Selection of firms for architect-engineer contracts. ...

  13. 48 CFR 36.602 - Selection of firms for architect-engineer contracts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... architect-engineer contracts. 36.602 Section 36.602 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Architect-Engineer Services 36.602 Selection of firms for architect-engineer contracts. ...

  14. 48 CFR 36.602 - Selection of firms for architect-engineer contracts.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... architect-engineer contracts. 36.602 Section 36.602 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Architect-Engineer Services 36.602 Selection of firms for architect-engineer contracts. ...

  15. 48 CFR 36.602 - Selection of firms for architect-engineer contracts.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... architect-engineer contracts. 36.602 Section 36.602 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Architect-Engineer Services 36.602 Selection of firms for architect-engineer contracts. ...

  16. Synthetic Cannabinoid and Mitragynine Exposure of Law Enforcement Agents During the Raid of an Illegal Laboratory - Nevada, 2014.

    PubMed

    Tapp, Loren; Ramsey, Jessica G; Wen, Anita; Gerona, Roy

    2017-12-01

    Synthetic cannabinoids (SCs), commonly known by the street name "Spice," are designer drugs of abuse that mimic the psychoactive effects of marijuana. Intentional SC use has resulted in multiple toxicities (1,2), but little is known about occupational SC exposure. After a federal agency's law enforcement personnel in Nevada reported irritability and feeling "high" after raiding illegal SC laboratories and processing seized SCs, a request for a health hazard evaluation was made by the agency to CDC's National Institute for Occupational Safety and Health (NIOSH) in 2014 to evaluate agents' occupational SC exposures. After making the request for a health hazard evaluation, federal agents conducted a raid of an illegal SC laboratory, with assistance from local law enforcement and Drug Enforcement Administration (DEA) personnel and with NIOSH investigators observing from a distance. After the raid, agents collected and processed material evidence. NIOSH investigators tested agents' urine for SC levels before and after the raid and measured SCs in the air and on surfaces after the raid. DEA determined that AB-PINACA (an SC compound) and mitragynine (a plant material with opium-like effects, also known as "kratom") were present in the illegal laboratory. AB-PINACA, its metabolites, and mitragynine were not detected in agents' urine before the raid; however, one or more of these substances was found in the urine of six of nine agents after the raid and processing of the SC evidence. AB-PINACA was detected in one surface wipe sample from the SC laboratory; none was detected in the air in the laboratory or in the offices of the law enforcement agency where the materials were processed after the raid. No policies were in place regarding work practices and use of personal protective equipment (PPE) during raids and evidence processing. To protect agents from SC exposures, NIOSH recommended that the agency require agents to wear a minimum level of PPE (e.g., protective gloves and disposable clothing) and undergo training in PPE and in handling and storing of contaminated evidence from SC laboratory raids. Showers and locker rooms also need to be provided so that agents can reduce contamination and prevent take-home exposure.

  17. 21 CFR 522.1066 - Glycopyrrolate.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... cats—(1) Amount. 5 micrograms per pound of body weight (0.25 milliliter per 10 pounds of body weight... cats. (2) Indications for use. As a preanesthetic agent. (3) Limitations. Federal law restricts this...

  18. 49 CFR 388.4 - Exchange of information.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... information to State. Information that comes to the attention of an employee of the Federal Motor Carrier... Motor Carrier Safety Administration. Information that comes to the attention of a duly authorized agent...

  19. Older partner selection promotes the prevalence of cooperation in evolutionary games.

    PubMed

    Yang, Guoli; Huang, Jincai; Zhang, Weiming

    2014-10-21

    Evolutionary games typically come with the interplays between evolution of individual strategy and adaptation to network structure. How these dynamics in the co-evolution promote (or obstruct) the cooperation is regarded as an important topic in social, economic, and biological fields. Combining spatial selection with partner choice, the focus of this paper is to identify which neighbour should be selected as a role to imitate during the process of co-evolution. Age, an internal attribute and kind of local piece of information regarding the survivability of the agent, is a significant consideration for the selection strategy. The analysis and simulations presented, demonstrate that older partner selection for strategy imitation could foster the evolution of cooperation. The younger partner selection, however, may decrease the level of cooperation. Our model highlights the importance of agent׳s age on the promotion of cooperation in evolutionary games, both efficiently and effectively. Copyright © 2014 Elsevier Ltd. All rights reserved.

  20. Attenuation of a select agent-excluded Burkholderia pseudomallei capsule mutant in hamsters.

    PubMed

    Gutierrez, Maria G; Warawa, Jonathan M

    2016-05-01

    Burkholderia pseudomallei is a Tier 1 select agent and potential bioweapon. Given it is potential to cause a lethal respiratory disease, research with fully virulent B. pseudomallei is conducted in Biosafety Level 3 (BSL-3) laboratory spaces. The logistical, financial, and administrative burden of Tier 1 select agent BSL-3 research has created an interest in mitigating such burdens through the use of either attenuated B. pseudomallei strains at BSL-2, or research with surrogate species, such as Burkholderia thailandensis. Previously, attenuated B. pseudomallei auxotroph mutants (asd and purM) have been approved for exclusion from select agent requirements, allowing for in vitro studies to be conducted at BSL-2. Acapsular B. pseudomallei mutants are known to be strongly attenuated in a variety of animal models, and yet acapsular B. pseudomallei mutants do not require nutritional supplementation, and can be studied within cultured macrophages, performing phenotypically similarly to parent strains. We demonstrate that the loss of a 30.8 kb region of the wcb capsule operon allows for a dramatic >4.46 log attenuation in a hamster intraperitoneal infection model, and report that this strain, JW270, has met criteria for exclusion from select agent requirements. Copyright © 2016 Elsevier B.V. All rights reserved.

  1. 31 CFR 205.2 - What definitions apply to this part?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... writing. Business day means a day when Federal Reserve Banks are open. Catalog of Federal Domestic... non-financial Federal assistance programs administered by agencies of the Federal government... Federal Program Agency is authorized by law to exercise judgment in awarding a grant and in selecting a...

  2. 31 CFR 205.2 - What definitions apply to this part?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... writing. Business day means a day when Federal Reserve Banks are open. Catalog of Federal Domestic... non-financial Federal assistance programs administered by agencies of the Federal government... Federal Program Agency is authorized by law to exercise judgment in awarding a grant and in selecting a...

  3. 31 CFR 205.2 - What definitions apply to this part?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... writing. Business day means a day when Federal Reserve Banks are open. Catalog of Federal Domestic... non-financial Federal assistance programs administered by agencies of the Federal government... Federal Program Agency is authorized by law to exercise judgment in awarding a grant and in selecting a...

  4. 31 CFR 205.2 - What definitions apply to this part?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... writing. Business day means a day when Federal Reserve Banks are open. Catalog of Federal Domestic... non-financial Federal assistance programs administered by agencies of the Federal government... Federal Program Agency is authorized by law to exercise judgment in awarding a grant and in selecting a...

  5. 76 FR 59623 - Defense Federal Acquisition Regulation Supplement; Only One Offer (DFARS Case 2011-D013)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-27

    ... : http://www.regulations.gov . Submit comments via the Federal eRulemaking portal by inserting ``DFARS Case 2011-D013'' under the heading ``Enter keyword or ID'' and selecting ``Search.'' Select the link...

  6. A Systematic Review of the Effectiveness of Antianxiety and Antidepressive Agents for Functional Dyspepsia.

    PubMed

    Hojo, Mariko; Nagahara, Akihito; Asaoka, Daisuke; Shimada, Yuji; Sasaki, Hitoshi; Matsumoto, Kohei; Takeda, Tsutomu; Ueyama, Hiroya; Matsumoto, Kenshi; Watanabe, Sumio

    2017-12-01

    Objective Functional dyspepsia (FD) is defined as persistent or recurrent pain or discomfort centered in the upper abdomen without organic disease. Psychosocial factors have been proposed as an important element in the pathophysiology of FD. Therefore, psychotropic agents having antianxiety or antidepressive action are expected to alleviate FD. We previously reported on the treatment of FD using such agents in a systematic review, wherein the effectiveness of the agents on FD was suggested, although there were several limitations. We searched for articles on this subject after our systematic review and re-reviewed them systematically. Methods Articles were searched for in MEDLINE from 2003 to 2014 using terms related to antianxiety or antidepressive agents. Clinical studies in which the effectiveness of such agents was clearly stated were selected from the retrieved articles. The newly selected and previously selected studies were combined, and statistical analyses were carried out. Results Nine studies were selected. Five of the studies indicated a significant symptomatic improvement using psychotropic drugs. A statistical analysis suggested a significant treatment effect of psychotropic agents having antianxiety or antidepressive action [pooled relative risk (PRR), 0.72; 95% confidence interval (95% CI), 0.52-0.99; p=0.0406] but did not show a significant benefit of treatment with agents having an antidepressive action alone (PRR, 0.63; 95% CI, 0.38-1.03; p=0.0665). Conclusion Our systematic review suggested that psychotropic drugs having antianxiety and antidepressive actions as a whole might be effective in alleviating FD symptoms, whereas those having only antidepressive action were not effective.

  7. A Systematic Review of the Effectiveness of Antianxiety and Antidepressive Agents for Functional Dyspepsia

    PubMed Central

    Hojo, Mariko; Nagahara, Akihito; Asaoka, Daisuke; Shimada, Yuji; Sasaki, Hitoshi; Matsumoto, Kohei; Takeda, Tsutomu; Ueyama, Hiroya; Matsumoto, Kenshi; Watanabe, Sumio

    2017-01-01

    Objective Functional dyspepsia (FD) is defined as persistent or recurrent pain or discomfort centered in the upper abdomen without organic disease. Psychosocial factors have been proposed as an important element in the pathophysiology of FD. Therefore, psychotropic agents having antianxiety or antidepressive action are expected to alleviate FD. We previously reported on the treatment of FD using such agents in a systematic review, wherein the effectiveness of the agents on FD was suggested, although there were several limitations. We searched for articles on this subject after our systematic review and re-reviewed them systematically. Methods Articles were searched for in MEDLINE from 2003 to 2014 using terms related to antianxiety or antidepressive agents. Clinical studies in which the effectiveness of such agents was clearly stated were selected from the retrieved articles. The newly selected and previously selected studies were combined, and statistical analyses were carried out. Results Nine studies were selected. Five of the studies indicated a significant symptomatic improvement using psychotropic drugs. A statistical analysis suggested a significant treatment effect of psychotropic agents having antianxiety or antidepressive action [pooled relative risk (PRR), 0.72; 95% confidence interval (95% CI), 0.52-0.99; p=0.0406] but did not show a significant benefit of treatment with agents having an antidepressive action alone (PRR, 0.63; 95% CI, 0.38-1.03; p=0.0665). Conclusion Our systematic review suggested that psychotropic drugs having antianxiety and antidepressive actions as a whole might be effective in alleviating FD symptoms, whereas those having only antidepressive action were not effective. PMID:29021437

  8. Natural selection of memory-one strategies for the iterated prisoner's dilemma.

    PubMed

    Kraines, D P; Kraines, V Y

    2000-04-21

    In the iterated Prisoner's Dilemma, mutually cooperative behavior can become established through Darwinian natural selection. In simulated interactions of stochastic memory-one strategies for the Iterated Prisoner's Dilemma, Nowak and Sigmund discovered that cooperative agents using a Pavlov (Win-Stay Lose-Switch) type strategy eventually dominate a random population. This emergence follows more directly from a deterministic dynamical system based on differential reproductive success or natural selection. When restricted to an environment of memory-one agents interacting in iterated Prisoner's Dilemma games with a 1% noise level, the Pavlov agent is the only cooperative strategy and one of very few others that cannot be invaded by a similar strategy. Pavlov agents are trusting but no suckers. They will exploit weakness but repent if punished for cheating. Copyright 2000 Academic Press.

  9. Distributed Cooperation Solution Method of Complex System Based on MAS

    NASA Astrophysics Data System (ADS)

    Weijin, Jiang; Yuhui, Xu

    To adapt the model in reconfiguring fault diagnosing to dynamic environment and the needs of solving the tasks of complex system fully, the paper introduced multi-Agent and related technology to the complicated fault diagnosis, an integrated intelligent control system is studied in this paper. Based on the thought of the structure of diagnostic decision and hierarchy in modeling, based on multi-layer decomposition strategy of diagnosis task, a multi-agent synchronous diagnosis federation integrated different knowledge expression modes and inference mechanisms are presented, the functions of management agent, diagnosis agent and decision agent are analyzed, the organization and evolution of agents in the system are proposed, and the corresponding conflict resolution algorithm in given, Layered structure of abstract agent with public attributes is build. System architecture is realized based on MAS distributed layered blackboard. The real world application shows that the proposed control structure successfully solves the fault diagnose problem of the complex plant, and the special advantage in the distributed domain.

  10. Enhancing Interrogation: Advancing a New Agenda

    DTIC Science & Technology

    2009-01-01

    cloaked in righteousness, and would make the American people less safe.”16 His clear message, delivered in an earli- er Fox News interview, is that...Scalia, a fan of Fox network’s hit drama 24, has championed the show’s federal agent protagonist, Jack Bauer, who regularly saves the nation by...with one based on “submission through humiliation and cruelty .”37 Even more damaging, Soufan contended, was the exclusion of FBI agents from further

  11. Experimental Evaluation of Suitability of Selected Multi-Criteria Decision-Making Methods for Large-Scale Agent-Based Simulations.

    PubMed

    Tučník, Petr; Bureš, Vladimír

    2016-01-01

    Multi-criteria decision-making (MCDM) can be formally implemented by various methods. This study compares suitability of four selected MCDM methods, namely WPM, TOPSIS, VIKOR, and PROMETHEE, for future applications in agent-based computational economic (ACE) models of larger scale (i.e., over 10 000 agents in one geographical region). These four MCDM methods were selected according to their appropriateness for computational processing in ACE applications. Tests of the selected methods were conducted on four hardware configurations. For each method, 100 tests were performed, which represented one testing iteration. With four testing iterations conducted on each hardware setting and separated testing of all configurations with the-server parameter de/activated, altogether, 12800 data points were collected and consequently analyzed. An illustrational decision-making scenario was used which allows the mutual comparison of all of the selected decision making methods. Our test results suggest that although all methods are convenient and can be used in practice, the VIKOR method accomplished the tests with the best results and thus can be recommended as the most suitable for simulations of large-scale agent-based models.

  12. Structural characterization of chemical warfare agent degradation products in decontamination solutions with proton band-selective (1)H-(31)P NMR spectroscopy.

    PubMed

    Koskela, Harri; Hakala, Ullastiina; Vanninen, Paula

    2010-06-15

    Decontamination solutions, which are usually composed of strong alkaline chemicals, are used for efficient detoxification of chemical warfare agents (CWAs). The analysis of CWA degradation products directly in decontamination solutions is challenging due to the nature of the matrix. Furthermore, occasionally an unforeseen degradation pathway can result in degradation products which could be eluded to in standard analyses. Here, we present the results of the application of proton band-selective (1)H-(31)P NMR spectroscopy, i.e., band-selective 1D (1)H-(31)P heteronuclear single quantum coherence (HSQC) and band-selective 2D (1)H-(31)P HSQC-total correlation spectroscopy (TOCSY), for ester side chain characterization of organophosphorus nerve agent degradation products in decontamination solutions. The viability of the approach is demonstrated with a test mixture of typical degradation products of nerve agents sarin, soman, and VX. The proton band-selective (1)H-(31)P NMR spectroscopy is also applied in characterization of unusual degradation products of VX in GDS 2000 solution.

  13. Congressional Testimony on Educational Innovations. Testimony to the Subcommittee on Elementary, Secondary and Vocational Education Committee on Education and Labor. U.S. House of Representatives. Rand Paper Series No. 5983.

    ERIC Educational Resources Information Center

    Berman, Paul

    This testimony summarizes the results of the Rand Corporation's change agent study of educational innovations funded by federal programs. The second section consists of policy recommendations for ESEA Title IV Consolidated Programs, Part C. The study aimed to help improve federal policies by describing how the process of innovation and educational…

  14. Technology Readiness Assessment (TRA) Deskbook

    DTIC Science & Technology

    2005-05-01

    information such as expiration date and lot number. DoD will probably be in a position to use a commercially proven technology with an inherently low...federal regulations, DoD was able to gain approval of pyridostigmine bromide for prophylaxis against the lethal effects of the soman nerve agent . H...www.fda.gov/cber/ H.4 ADDITIONAL INFORMATION Federal Food, Drug, and Cosmetic (FD&C) Act United States Code, Title 21 – Food and Drugs (21USC

  15. Medical and biohazardous waste generator`s guide: Revision 1

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1994-09-01

    This Guide describes the procedures required to comply with all federal and state laws and regulations and Lawrence Berkeley Laboratory (LBL) policy applicable to medical and biohazardous waste. The members of the LBL Biological Safety Subcommittee participated in writing these policies and procedures. The procedures and policies in this Guide apply to LBL personnel who work with infectious agents or potentially infectious agents, publicly perceived infectious items or materials (e.g., medical gloves, culture dishes), and sharps (e.g., needles, syringes, razor blades). If medical or biohazardous waste is contaminated or mixed with a hazardous chemical or material, with a radioactive material,more » or with both, the waste will be handled in accordance with the applicable federal and State of California laws and regulations for hazardous, radioactive, or mixed waste.« less

  16. Antibiosis and bmyB Gene Presence As Prevalent Traits for the Selection of Efficient Bacillus Biocontrol Agents against Crown Gall Disease.

    PubMed

    Frikha-Gargouri, Olfa; Ben Abdallah, Dorra; Bhar, Ilhem; Tounsi, Slim

    2017-01-01

    This study aimed to improve the screening method for the selection of Bacillus biocontrol agents against crown gall disease. The relationship between the strain biocontrol ability and their in vitro studied traits was investigated to identify the most important factors to be considered for the selection of effective biocontrol agents. In fact, previous selection procedure relying only on in vitro antibacterial activity was shown to be not suitable in some cases. A direct plant-protection strategy was performed to screen the 32 Bacillus biocontrol agent candidates. Moreover, potential in vitro biocontrol traits were investigated including biofilm formation, motility, hemolytic activity, detection of lipopeptide biosynthetic genes ( sfp, ituC and bmyB ) and production of antibacterial compounds. The obtained results indicated high correlations of the efficiency of the biocontrol with the reduction of gall weight ( p = 0.000) and the antibacterial activity in vitro ( p = 0.000). Moreover, there was strong correlations of the efficiency of the biocontrol ( p = 0.004) and the reduction in gall weight ( p = 0.000) with the presence of the bmyB gene. This gene directs the synthesis of the lipopeptide bacillomycin belonging to the iturinic family of lipopeptides. These results were also confirmed by the two-way hierarchical cluster analysis and the correspondence analysis showing the relatedness of these four variables. According to the obtained results a new screening procedure of Bacillus biocontrol agents against crown gall disease could be advanced consisting on two step selection procedure. The first consists on selecting strains with high antibacterial activity in vitro or those harbouring the bmyB gene. Further selection has to be performed on tomato plants in vivo . Moreover, based on the results of the biocontrol assay, five potent strains exhibiting high biocontrol abilities were selected. They were identified as Bacillus subtilis or Bacillus amyloliquefaciens . These strains were found to produce either surfactin or surfactin and iturin lipopeptides. In conclusion, our study presented a new and effective method to evaluate the biocontrol ability of antagonistic Bacillus strains against crown gall disease that could increase the efficiency of screening method of biocontrol agents. Besides, the selected strains could be used as novel biocontrol agents against pathogenic Agrobacterium tumefaciens strains.

  17. Antibiosis and bmyB Gene Presence As Prevalent Traits for the Selection of Efficient Bacillus Biocontrol Agents against Crown Gall Disease

    PubMed Central

    Frikha-Gargouri, Olfa; Ben Abdallah, Dorra; Bhar, Ilhem; Tounsi, Slim

    2017-01-01

    This study aimed to improve the screening method for the selection of Bacillus biocontrol agents against crown gall disease. The relationship between the strain biocontrol ability and their in vitro studied traits was investigated to identify the most important factors to be considered for the selection of effective biocontrol agents. In fact, previous selection procedure relying only on in vitro antibacterial activity was shown to be not suitable in some cases. A direct plant-protection strategy was performed to screen the 32 Bacillus biocontrol agent candidates. Moreover, potential in vitro biocontrol traits were investigated including biofilm formation, motility, hemolytic activity, detection of lipopeptide biosynthetic genes (sfp, ituC and bmyB) and production of antibacterial compounds. The obtained results indicated high correlations of the efficiency of the biocontrol with the reduction of gall weight (p = 0.000) and the antibacterial activity in vitro (p = 0.000). Moreover, there was strong correlations of the efficiency of the biocontrol (p = 0.004) and the reduction in gall weight (p = 0.000) with the presence of the bmyB gene. This gene directs the synthesis of the lipopeptide bacillomycin belonging to the iturinic family of lipopeptides. These results were also confirmed by the two-way hierarchical cluster analysis and the correspondence analysis showing the relatedness of these four variables. According to the obtained results a new screening procedure of Bacillus biocontrol agents against crown gall disease could be advanced consisting on two step selection procedure. The first consists on selecting strains with high antibacterial activity in vitro or those harbouring the bmyB gene. Further selection has to be performed on tomato plants in vivo. Moreover, based on the results of the biocontrol assay, five potent strains exhibiting high biocontrol abilities were selected. They were identified as Bacillus subtilis or Bacillus amyloliquefaciens. These strains were found to produce either surfactin or surfactin and iturin lipopeptides. In conclusion, our study presented a new and effective method to evaluate the biocontrol ability of antagonistic Bacillus strains against crown gall disease that could increase the efficiency of screening method of biocontrol agents. Besides, the selected strains could be used as novel biocontrol agents against pathogenic Agrobacterium tumefaciens strains. PMID:28855909

  18. 3 CFR 13546 - Executive Order 13546 of July 2, 2010. Optimizing the Security of Biological Select Agents and...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... discourage research or other legitimate activities. (c) Understanding that research and laboratory work on... consultation, as needed, on topics of relevance to the SAP. Sec. 8. Sharing of Select Agent Program Information...

  19. 9 CFR 121.4 - Overlap select agents and toxins.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... in paragraph (b) of this section that have been genetically modified. (d) Overlap select agents or... OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS POSSESSION, USE... elements, recombinant nucleic acids, and recombinant organisms: (1) Nucleic acids that can produce...

  20. Research on monitoring system of water resources in Shiyang River Basin based on Multi-agent

    NASA Astrophysics Data System (ADS)

    Zhao, T. H.; Yin, Z.; Song, Y. Z.

    2012-11-01

    The Shiyang River Basin is the most populous, economy relatively develop, the highest degree of development and utilization of water resources, water conflicts the most prominent, ecological environment problems of the worst hit areas in Hexi inland river basin in Gansu province. the contradiction between people and water is aggravated constantly in the basin. This text combines multi-Agent technology with monitoring system of water resource, the establishment of a management center, telemetry Agent Federation, as well as the communication network between the composition of the Shiyang River Basin water resources monitoring system. By taking advantage of multi-agent system intelligence and communications coordination to improve the timeliness of the basin water resources monitoring.

  1. Non-antibiotic selection systems for soybean somatic embryos: the lysine analog aminoethyl-cysteine as a selection agent

    PubMed Central

    2009-01-01

    Background In soybean somatic embryo transformation, the standard selection agent currently used is hygromycin. It may be preferable to avoid use of antibiotic resistance genes in foods. The objective of these experiments was to develop a selection system for producing transgenic soybean somatic embryos without the use of antibiotics such as hygromycin. Results When tested against different alternate selection agents our studies show that 0.16 μg/mL glufosinate, 40 mg/L isopropylamine-glyphosate, 0.5 mg/mL (S-(2 aminoethyl)-L-cysteine) (AEC) and the acetolactate synthase (ALS) inhibitors Exceed® and Synchrony® both at 150 μg/mL inhibited soybean somatic embryo growth. Even at the concentration of 2 mg/mL, lysine+threonine (LT) were poor selection agents. The use of AEC may be preferable since it is a natural compound. Unlike the plant enzyme, dihydrodipicolinate synthase (DHPS) from E. coli is not feed-back inhibited by physiological concentrations of lysine. The dapA gene which codes for E. coli DHPS was expressed in soybean somatic embryos under the control of the CaMV 35S promoter. Following introduction of the construct into embryogenic tissue of soybean, transgenic events were recovered by incubating the tissue in liquid medium containing AEC at a concentration of 5 mM. Only transgenic soybeans were able to grow at this concentration of AEC; no escapes were observed. Conclusion Genetically engineered soybeans expressing a lysine insensitive DHPS gene can be selected with the non-antibiotic selection agent AEC. We also report here the inhibitory effects of glufosinate, (isopropylamine-glyphosate) (Roundup®), AEC and the ALS inhibitors Exceed® and Synchrony® against different tissues of soybean PMID:19922622

  2. Implementation of a Personnel Reliability Program as a Facilitator of Biosafety and Biosecurity Culture in BSL-3 and BSL-4 Laboratories

    PubMed Central

    Weaver, Patrick; Fitch, J. Patrick; Johnson, Barbara; Pearl, R. Marene

    2013-01-01

    In late 2010, the National Biodefense Analysis and Countermeasures Center (NBACC) implemented a Personnel Reliability Program (PRP) with the goal of enabling active participation by its staff to drive and improve the biosafety and biosecurity culture at the organization. A philosophical keystone for accomplishment of NBACC's scientific mission is simultaneous excellence in operations and outreach. Its personnel reliability program builds on this approach to: (1) enable and support a culture of responsibility based on human performance principles, (2) maintain compliance with regulations, and (3) address the risk associated with the insider threat. Recently, the Code of Federal Regulations (CFR) governing use and possession of biological select agents and toxins (BSAT) was amended to require a pre-access suitability assessment and ongoing evaluation for staff accessing Tier 1 BSAT. These 2 new requirements are in addition to the already required Federal Bureau of Investigation (FBI) Security Risk Assessment (SRA). Two years prior to the release of these guidelines, NBACC developed its PRP to supplement the SRA requirement as a means to empower personnel and foster an operational environment where any and all work with BSAT is conducted in a safe, secure, and reliable manner. PMID:23745523

  3. 9 CFR 121.4 - Overlap select agents and toxins.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... this section that have been genetically modified. (d) Overlap select agents or toxins that meet any of... OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS POSSESSION, USE...) Genetic elements, recombinant and/or synthetic nucleic acids, and recombinant and/or synthetic organisms...

  4. 9 CFR 121.4 - Overlap select agents and toxins.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... this section that have been genetically modified. (d) Overlap select agents or toxins that meet any of... OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS POSSESSION, USE...) Genetic elements, recombinant and/or synthetic nucleic acids, and recombinant and/or synthetic organisms...

  5. 42 CFR 73.9 - Responsible Official.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... toxins must be immediately reported by telephone, facsimile, or e-mail: Bacillus anthracis, Botulinum... SELECT AGENTS AND TOXINS § 73.9 Responsible Official. (a) An individual or entity required to register...) Ensure that annual inspections are conducted for each laboratory where select agents or toxins are stored...

  6. The Scarlet Letter of Alkylation: A Mini Review of Selective Alkylating Agents

    PubMed Central

    Oronsky, Bryan T; Reid, Tony; Knox, Susan J; Scicinski, Jan J

    2012-01-01

    If there were a stigma scale for chemotherapy, alkylating agents would be ranked at the top of the list. The chemical term alkylation is associated with nonselective toxicity, an association that dates back to the use of nitrogen mustards during World War I as chemical warfare agents. That this stigma persists and extends to compounds that, through selectivity, attempt to “tame” the indiscriminate destructive potential of alkylation is the subject of this review. Selective alkylation, as it is referred to herein, constitutes an extremely nascent and dynamic field in oncology. The pharmacodynamic response to this selective strategy depends on a delicate kinetic balance between specificity and the rate and extent of binding. Three representative compounds are presented: RRx-001, 3-bromopyruvate, and TH-302. The main impetus for the development of these compounds has been the avoidance of the serious complications of traditional alkylating agents; therefore, it is the thesis of this review that they should not experience stigma by association. PMID:22937173

  7. 78 FR 5838 - NRC Enforcement Policy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-28

    ... submit comments by any of the following methods: Federal Rulemaking Web site: Go to http://www... of the following methods: Federal Rulemaking Web site: Go to http://www.regulations.gov and search... the search, select ``ADAMS Public Documents'' and then select ``Begin Web-based ADAMS Search.'' For...

  8. 48 CFR 836.602-4 - Selection authority.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Selection authority. 836.602-4 Section 836.602-4 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS SPECIAL... those capacities, are designated as the approving officials for the recommendations of the respective...

  9. 76 FR 3877 - Effectiveness of Federal Agency Participation in Standardization in Select Technology Sectors for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-21

    ... DEPARTMENT OF COMMERCE National Institute of Standards and Technology [Docket Number 0909100442-1012-03] Effectiveness of Federal Agency Participation in Standardization in Select Technology Sectors for National Science and Technology Council's Sub-Committee on Standardization; Extension of Comment...

  10. 2001 Federal Radionavigation Systems.

    DOT National Transportation Integrated Search

    2001-12-01

    This edition of Federal Radio navigation Systems (FRS) updates and replaces sections in the 1999 Federal Radio navigation Plan (FRP) relating to Government roles and responsibilities, system selection considerations, civil user requirements, and syst...

  11. 76 FR 48862 - Sunshine Act Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-09

    ... by United Taconite, LLC, Docket No. LAKE 2010-128-M. (Issues include whether an agent of a limited liability company can be liable for a civil penalty under section 110(c) of the Federal Mine Safety and...

  12. 17 CFR 229.511 - (Item 511) Other expenses of issuance and distribution.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... fees, Federal taxes, States taxes and fees, trustees' and transfer agents' fees, costs of printing and engraving, and legal, accounting, and engineering fees shall be itemized separately. Include as a separate...

  13. 76 FR 80727 - Flexible Implementation of the Mercury and Air Toxics Standards Rule

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-27

    ... uncertainty,'' and should include engagement and coordination with DOE, the Federal Energy Regulatory... departments, agencies, or entities, its officers, employees, or agents, or any other person. You are hereby...

  14. 42 CFR 73.9 - Responsible Official.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... SELECT AGENTS AND TOXINS § 73.9 Responsible Official. (a) An individual or entity required to register... onsite incidents involving select agents and toxins in accordance with the entity's incident response... toxins are stored or used in order to determine compliance with the requirements of this part. The...

  15. 42 CFR 73.9 - Responsible Official.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... SELECT AGENTS AND TOXINS § 73.9 Responsible Official. (a) An individual or entity required to register... onsite incidents involving select agents and toxins in accordance with the entity's incident response... toxins are stored or used in order to determine compliance with the requirements of this part. The...

  16. 287(g): Cross-Delegating State and Local Law Enforcement Officers with Federal Immigration Authority - Homeland Security Remedy or Rue?

    DTIC Science & Technology

    2008-12-01

    ICE Office of Investigations uses its legal authority to investigate issues such as immigration crime , human rights violations, and human smuggling...communities. Crimes committed by foreign nationals — many exploited by terrorists — pose ideological, legal and resource challenges to state and local...umbrella of the Special Agent In Charge (SAC) in Denver , Colorado . Utah ICE OI falls under the supervisory umbrella of the Assistant Special Agent In

  17. Workload-Based Automated Interface Mode Selection

    DTIC Science & Technology

    2012-03-22

    Process . . . . . . . . . . . . . . . . . . . . . 31 3.5.10 Agent Reward Function . . . . . . . . . . . . . . . . 31 3.5.11 Accelerated Learning... Strategies . . . . . . . . . . . . 31 4. Experimental Methodology . . . . . . . . . . . . . . . . . . . . . . . . 33 4.1 System Engineering Methodology...26 5. Agent state function. . . . . . . . . . . . . . . . . . . . . . . . . . . 28 6. Agent reward function

  18. Pyropheophorbide 2-deoxyglucosamide: a new photosensitizer targeting glucose transporters.

    PubMed

    Zhang, Min; Zhang, Zhihong; Blessington, Dana; Li, Hui; Busch, Theresa M; Madrak, Vanessa; Miles, Jeremy; Chance, Britton; Glickson, Jerry D; Zheng, Gang

    2003-01-01

    To prepare near-infrared fluorescence imaging and photodynamic therapy agents targeted at glucose transporters, pyropheophorbide 2-deoxyglucosamide (Pyro-2DG) was synthesized and evaluated in a 9L glioma rat model. Fluorescence imaging studies demonstrate that Pyro-2DG is selectively accumulated in the tumor. Upon its photoactivation, we demonstrate that this agent efficiently causes selective mitochondrial damage to the region of a tumor that was photoirradiated after administration of this agent, but does not affect tissues photoirradiated in the absence of the agent or tissues treated with the agent that are not photoirradiated. Preliminary confocal microscopy studies suggest that Pyro-2DG is delivered and trapped in tumor cells via the GLUT/hexokinase pathway and therefore is useful both as a tumor-targeted NIR fluorescence imaging probe and as a PDT agent for the destruction of cancer.

  19. 48 CFR 301.603-2 - Selection and appointment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Selection and appointment. 301.603-2 Section 301.603-2 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES GENERAL... individual as a Contracting Officer only when a valid organizational need is demonstrated and after...

  20. 48 CFR 301.603-2 - Selection and appointment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Selection and appointment. 301.603-2 Section 301.603-2 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES GENERAL... individual as a Contracting Officer only when a valid organizational need is demonstrated and after...

  1. 48 CFR 1419.803 - Selecting acquisitions for the 8(a) Program.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Selecting acquisitions for the 8(a) Program. 1419.803 Section 1419.803 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Contracting with the Small Business Administration...

  2. 18 CFR 5.3 - Process selection.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Process selection. 5.3 Section 5.3 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT INTEGRATED LICENSE APPLICATION PROCESS § 5.3 Process...

  3. Agent-specific learning signals for self–other distinction during mentalising

    PubMed Central

    Dolan, Raymond J.; Kurth-Nelson, Zeb

    2018-01-01

    Humans have a remarkable ability to simulate the minds of others. How the brain distinguishes between mental states attributed to self and mental states attributed to someone else is unknown. Here, we investigated how fundamental neural learning signals are selectively attributed to different agents. Specifically, we asked whether learning signals are encoded in agent-specific neural patterns or whether a self–other distinction depends on encoding agent identity separately from this learning signal. To examine this, we tasked subjects to learn continuously 2 models of the same environment, such that one was selectively attributed to self and the other was selectively attributed to another agent. Combining computational modelling with magnetoencephalography (MEG) enabled us to track neural representations of prediction errors (PEs) and beliefs attributed to self, and of simulated PEs and beliefs attributed to another agent. We found that the representational pattern of a PE reliably predicts the identity of the agent to whom the signal is attributed, consistent with a neural self–other distinction implemented via agent-specific learning signals. Strikingly, subjects exhibiting a weaker neural self–other distinction also had a reduced behavioural capacity for self–other distinction and displayed more marked subclinical psychopathological traits. The neural self–other distinction was also modulated by social context, evidenced in a significantly reduced decoding of agent identity in a nonsocial control task. Thus, we show that self–other distinction is realised through an encoding of agent identity intrinsic to fundamental learning signals. The observation that the fidelity of this encoding predicts psychopathological traits is of interest as a potential neurocomputational psychiatric biomarker. PMID:29689053

  4. Agent-specific learning signals for self-other distinction during mentalising.

    PubMed

    Ereira, Sam; Dolan, Raymond J; Kurth-Nelson, Zeb

    2018-04-01

    Humans have a remarkable ability to simulate the minds of others. How the brain distinguishes between mental states attributed to self and mental states attributed to someone else is unknown. Here, we investigated how fundamental neural learning signals are selectively attributed to different agents. Specifically, we asked whether learning signals are encoded in agent-specific neural patterns or whether a self-other distinction depends on encoding agent identity separately from this learning signal. To examine this, we tasked subjects to learn continuously 2 models of the same environment, such that one was selectively attributed to self and the other was selectively attributed to another agent. Combining computational modelling with magnetoencephalography (MEG) enabled us to track neural representations of prediction errors (PEs) and beliefs attributed to self, and of simulated PEs and beliefs attributed to another agent. We found that the representational pattern of a PE reliably predicts the identity of the agent to whom the signal is attributed, consistent with a neural self-other distinction implemented via agent-specific learning signals. Strikingly, subjects exhibiting a weaker neural self-other distinction also had a reduced behavioural capacity for self-other distinction and displayed more marked subclinical psychopathological traits. The neural self-other distinction was also modulated by social context, evidenced in a significantly reduced decoding of agent identity in a nonsocial control task. Thus, we show that self-other distinction is realised through an encoding of agent identity intrinsic to fundamental learning signals. The observation that the fidelity of this encoding predicts psychopathological traits is of interest as a potential neurocomputational psychiatric biomarker.

  5. Federal Funding Sources for Rural Areas: Fiscal Year 1998. Rural Information Center Publications Series, No. 59. Revised Edition.

    ERIC Educational Resources Information Center

    Reynnells, M. Louise, Comp.

    This publication lists 265 federal funding programs available to rural areas. The programs were selected from the Catalog of Federal Domestic Assistance, 1997, which is available online from FAPRS (the Federal Assistance Programs Retrieval System). Entries are listed under the following federal departments or agencies: Department of Agriculture,…

  6. Federal Funding Sources for Rural Areas. Rural Information Center Publication Series, No. 49. Revised Edition.

    ERIC Educational Resources Information Center

    Reynnells, M. Louise, Comp.

    This document lists 248 federal funding programs available to rural areas. The programs were selected from the Catalog of Federal Domestic Assistance, 1995, which is available online from the Federal Assistance Programs Retrieval System (FAPRS). Entries are listed under the following federal departments or agencies: Department of Agriculture,…

  7. Monochloramine inactivation of bacterial select agents.

    PubMed

    Rose, Laura J; Rice, Eugene W; Hodges, Lisa; Peterson, Alicia; Arduino, Matthew J

    2007-05-01

    Seven species of bacterial select agents were tested for susceptibility to monochloramine. Under test conditions, the monochloramine routinely maintained in potable water would reduce six of the species by 2 orders of magnitude within 4.2 h. Bacillus anthracis spores would require up to 3.5 days for the same inactivation with monochloramine.

  8. Application of Grazing-Inspired Guidance Laws to Autonomous Information Gathering

    DTIC Science & Technology

    2014-09-01

    paths by expressing it as the Selective Traveling Salesman Problem subject to dynamic constraints. Tisdale et al. [11] utilized a receding horizon ap...vehicle failures by halving the initial fuel level on selected agents. Note that simulations start with agents 50s travel time away from where they

  9. Effects of anesthetic agents on in vivo axonal HCN current in normal mice.

    PubMed

    Osaki, Yusuke; Nodera, Hiroyuki; Banzrai, Chimeglkham; Endo, Sachiko; Takayasu, Hirokazu; Mori, Atsuko; Shimatani, Yoshimitsu; Kaji, Ryuji

    2015-10-01

    The objective was to study the in vivo effects of anesthetic agents on peripheral nerve excitability. Normal male mice were anesthetized by either isoflurane inhalation or a combination of medetomidine, midazolam, and butorphanol intraperitoneal injection ("triple agents"). Immediately after induction, the tail sensory nerve action potential was recorded and its excitability was monitored. Under both anesthetic protocols, there was an interval excitability change by long hyperpolarizing currents. There was greater threshold reduction approximately 30min post induction, in comparison to immediately post induction. Other excitability parameters were stable over time. Modeling suggested interval suppression of internodal H conductance or leak current. Anesthetic agents affected responses to long hyperpolarizing currents. Axonal excitability during intraoperative monitoring may be affected by anesthetic agents. Interpretation of interval excitability changes under anesthesia requires caution, especially with long hyperpolarizing currents. Copyright © 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

  10. 41 CFR 301-10.162 - When may I use other than coach-class train accommodations?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES ALLOWABLE TRAVEL EXPENSES...-class accommodations would endanger your life or Government property; (2) You are an agent on protective...

  11. 75 FR 44231 - Defense Representative Guam, Commonwealth of the Northern Mariana Islands, Federated States of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-28

    ...: After carefully weighing the operational and environmental consequences of the Proposed Action, the... Executive Agent for management of the MIRC. The proposed action does not involve extensive changes to MIRC...

  12. 10 CFR 435.306 - Selecting a life cycle effective proposed building design.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Selecting a life cycle effective proposed building design. 435.306 Section 435.306 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY STANDARDS FOR NEW FEDERAL LOW-RISE RESIDENTIAL BUILDINGS Mandatory Energy Efficiency Standards for Federal...

  13. 10 CFR 436.33 - Procedures and methods for contractor selection.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...) May state that if the Federal agency requires a detailed energy survey which identifies life cycle... savings performance project, Federal agencies shall publish a Commerce Business Daily notice which... select a firm on a qualified list to conduct the project. (4) If a proposed energy cost savings project...

  14. JPRS Report, Science & Technology, Europe & Latin America, Brazil: Selections from the 1987 Federal S&T Budget.

    DTIC Science & Technology

    1988-02-24

    of Goias 67 . Federal University of the State of Rio de Janeiro 68 . Federal University of Juiz de Fora 68 . Federal University of Minas Gerais...Federal University of Rio Grande do Norte 72 . Federal University of Rio Grande do Sul • 72 . Federal University of Rio de Janeiro 73...University of Rio de Janeiro 75 . School of Agrarian Sciences of Para 76 . School of Medicine of the Minas Triangle 77 . Federal Technological Education

  15. Experimental Evaluation of Suitability of Selected Multi-Criteria Decision-Making Methods for Large-Scale Agent-Based Simulations

    PubMed Central

    2016-01-01

    Multi-criteria decision-making (MCDM) can be formally implemented by various methods. This study compares suitability of four selected MCDM methods, namely WPM, TOPSIS, VIKOR, and PROMETHEE, for future applications in agent-based computational economic (ACE) models of larger scale (i.e., over 10 000 agents in one geographical region). These four MCDM methods were selected according to their appropriateness for computational processing in ACE applications. Tests of the selected methods were conducted on four hardware configurations. For each method, 100 tests were performed, which represented one testing iteration. With four testing iterations conducted on each hardware setting and separated testing of all configurations with the–server parameter de/activated, altogether, 12800 data points were collected and consequently analyzed. An illustrational decision-making scenario was used which allows the mutual comparison of all of the selected decision making methods. Our test results suggest that although all methods are convenient and can be used in practice, the VIKOR method accomplished the tests with the best results and thus can be recommended as the most suitable for simulations of large-scale agent-based models. PMID:27806061

  16. Evolving effective behaviours to interact with tag-based populations

    NASA Astrophysics Data System (ADS)

    Yucel, Osman; Crawford, Chad; Sen, Sandip

    2015-07-01

    Tags and other characteristics, externally perceptible features that are consistent among groups of animals or humans, can be used by others to determine appropriate response strategies in societies. This usage of tags can be extended to artificial environments, where agents can significantly reduce cognitive effort spent on appropriate strategy choice and behaviour selection by reusing strategies for interacting with new partners based on their tags. Strategy selection mechanisms developed based on this idea have successfully evolved stable cooperation in games such as the Prisoner's Dilemma game but relies upon payoff sharing and matching methods that limit the applicability of the tag framework. Our goal is to develop a general classification and behaviour selection approach based on the tag framework. We propose and evaluate alternative tag matching and adaptation schemes for a new, incoming individual to select appropriate behaviour against any population member of an existing, stable society. Our proposed approach allows agents to evolve both the optimal tag for the environment as well as appropriate strategies for existing agent groups. We show that these mechanisms will allow for robust selection of optimal strategies by agents entering a stable society and analyse the various environments where this approach is effective.

  17. What Influences Agents to Pursue a Career in Extension?

    ERIC Educational Resources Information Center

    Arnold, Shannon; Place, Nick

    2010-01-01

    The qualitative study reported here explored why agricultural agents pursue an Extension career. A purposive sample was used to select twelve Florida agricultural agents. Interviews investigated positive and negative influences that affected agents' employment decisions. Grounded theory was used as the primary data analysis method (Strauss &…

  18. Double agents and secret agents: the emerging fields of exogenous chemical exchange saturation transfer and T2-exchange magnetic resonance imaging contrast agents for molecular imaging.

    PubMed

    Daryaei, Iman; Pagel, Mark D

    2015-01-01

    Two relatively new types of exogenous magnetic resonance imaging contrast agents may provide greater impact for molecular imaging by providing greater specificity for detecting molecular imaging biomarkers. Exogenous chemical exchange saturation transfer (CEST) agents rely on the selective saturation of the magnetization of a proton on an agent, followed by chemical exchange of a proton from the agent to water. The selective detection of a biomarker-responsive CEST signal and an unresponsive CEST signal, followed by the ratiometric comparison of these signals, can improve biomarker specificity. We refer to this improvement as a "double-agent" approach to molecular imaging. Exogenous T 2 -exchange agents also rely on chemical exchange of protons between the agent and water, especially with an intermediate rate that lies between the slow exchange rates of CEST agents and the fast exchange rates of traditional T 1 and T 2 agents. Because of this intermediate exchange rate, these agents have been relatively unknown and have acted as "secret agents" in the contrast agent research field. This review exposes these secret agents and describes the merits of double agents through examples of exogenous agents that detect enzyme activity, nucleic acids and gene expression, metabolites, ions, redox state, temperature, and pH. Future directions are also provided for improving both types of contrast agents for improved molecular imaging and clinical translation. Therefore, this review provides an overview of two new types of exogenous contrast agents that are becoming useful tools within the armamentarium of molecular imaging.

  19. Biological and chemical terrorism: strategic plan for preparedness and response. Recommendations of the CDC Strategic Planning Workgroup.

    PubMed

    2000-04-21

    The U.S. national civilian vulnerability to the deliberate use of biological and chemical agents has been highlighted by recognition of substantial biological weapons development programs and arsenals in foreign countries, attempts to acquire or possess biological agents by militants, and high-profile terrorist attacks. Evaluation of this vulnerability has focused on the role public health will have detecting and managing the probable covert biological terrorist incident with the realization that the U.S. local, state, and federal infrastructure is already strained as a result of other important public health problems. In partnership with representatives for local and state health departments, other federal agencies, and medical and public health professional associations, CDC has developed a strategic plan to address the deliberate dissemination of biological or chemical agents. The plan contains recommendations to reduce U.S. vulnerability to biological and chemical terrorism--preparedness planning, detection and surveillance, laboratory analysis, emergency response, and communication systems. Training and research are integral components for achieving these recommendations. Success of the plan hinges on strengthening the relationships between medical and public health professionals and on building new partnerships with emergency management, the military, and law enforcement professionals.

  20. Funding Solar Projects at Federal Agencies: Mechanisms and Selection Criteria (Brochure)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    Implementing solar energy projects at federal facilities is a process. The project planning phase of the process includes determining goals, building a team, determining site feasibility and selecting the appropriate project funding tool. This fact sheet gives practical guidance to assist decision-makers with understanding and selecting the funding tool that would best address their site goals. Because project funding tools are complex, federal agencies should seek project assistance before making final decisions. High capital requirements combined with limits on federal agency energy contracts create challenges for funding solar projects. Solar developers typically require long-term contracts (15-20) years to spread outmore » the initial investment and to enable payments similar to conventional utility bill payments. In the private sector, 20-year contracts have been developed, vetted, and accepted, but the General Services Administration (GSA) contract authority (federal acquisition regulation [FAR] part 41) typically limits contract terms to 10 years. Payments on shorter-term contracts make solar economically unattractive compared with conventional generation. However, in several instances, the federal sector has utilized innovative funding tools that allow long-term contracts or has created a project package that is economically attractive within a shorter contract term.« less

  1. Biodefense research: can secrecy and safety coexist?

    PubMed

    Kahn, Laura H

    2004-01-01

    Over the next 10 years, the United States will spend 6 billion US dollars to develop countermeasures against biological and chemical weapons. Much of this research on highly virulent pathogens will be done in academic settings around the country. This article explores the challenges in ensuring secrecy to protect national security while accommodating the right of local communities to have access to safety information regarding select agents and laboratory-acquired infections. Secrecy has been defended as being vital for protecting national security. Problems with secrecy can include the misinterpretation of intentions, particularly in laboratories located in nuclear weapons design facilities, and the restricted access to information relevant to public health and safety. While federal select agent legislation requires laboratories to have emergency plans in place with first responders, these plans do not necessarily include public health professionals, who will be responsible for any future public health action, such as quarantine, surveillance, or mass vaccinations, in the unlikely event that a laboratory-acquired infection spreads into a community. Laboratory-acquired infections do occur, even with the best safety mechanisms in place; however, the epidemiology of the incidence and severity of these infections are not known since there is no national surveillance reporting system. Evidence suggests that many of these infections occur in the absence of an actual laboratory accident. The best emergency plans and surveillance systems are only as good as the participation and vigilance of the laboratory workers themselves. Thus, laboratory workers have a responsibility to themselves and others to report all laboratory accidents and spills, regardless how minor. In addition, they should have a lower threshold than normal in seeking medical attention when feeling ill, and their physicians should be aware of what pathogens they work with to reduce the risk of a delay in diagnosis.

  2. Public health response to an imported case of canine melioidosis.

    PubMed

    Ryan, C W; Bishop, K; Blaney, D D; Britton, S J; Cantone, F; Egan, C; Elrod, M G; Frye, C W; Maxted, A M; Perkins, G

    2018-06-01

    Melioidosis in humans presents variably as fulminant sepsis, pneumonia, skin infection and solid organ abscesses. It is caused by Burkholderia pseudomallei, which in the United States is classified as a select agent, with "potential to pose a severe threat to both human and animal health, to plant health or to animal and plant products" (Federal Select Agent Program, http://www.selectagents.gov/, accessed 22 September 2016). Burkholderia pseudomallei is found in soil and surface water in the tropics, especially South-East Asia and northern Australia, where melioidosis is endemic. Human cases are rare in the United States and are usually associated with travel to endemic areas. Burkholderia pseudomallei can also infect animals. We describe a multijurisdictional public health response to a case of subclinical urinary B. pseudomallei infection in a dog that had been adopted into upstate New York from a shelter in Thailand. Investigation disclosed three human contacts with single, low-risk exposures to the dog's urine at his residence, and 16 human contacts with possible exposure to his urine or culture isolates at a veterinary hospital. Contacts were offered various combinations of symptom/fever monitoring, baseline and repeat B. pseudomallei serologic testing, and antibiotic post-exposure prophylaxis, depending on the nature of their exposure and their personal medical histories. The dog's owner accepted recommendations from public health authorities and veterinary clinicians for humane euthanasia. A number of animal rescue organizations actively facilitate adoptions into the United States of shelter dogs from South-East Asia. This may result in importation of B. pseudomallei into almost any community, with implications for human and animal health. © 2018 Blackwell Verlag GmbH.

  3. Effect of selection agents to Chrysanthemum (Chrysanthemum morifolium) callus growth after Agrobacterium-mediated genetic transformation

    NASA Astrophysics Data System (ADS)

    Sjahril, R.; Jamaluddin, I.; Nadir, M.; Asman; Dungga, N. E.

    2018-05-01

    Genetic transformation mediated by Agrobacterium tumefaciens requires an efficient selection method for successful progress of transformation. This study aims to determine the concentration and kind of antibiotics and selection agents used during transformation to formulate standard protocol of chrysanthemum in the process of propagating disease resistant Chrysanthemum mediated by Agrobacterium tumefaciens EHA105 (pEKB-WD). The experiments were performed by planting chrysanthemum explants leaf cutting (5 mm diameter on NAA medium 2 mg L-1 BAP 2 mg L-1) with addition of Kanamycin: 25, 50, 100, 150 and 200 (mg L-1); Hygromycin: 5, 10, 25, 50 and 75 (mg L-1); Paromomycin: 10, 25, 50, 75 and 100 (mg L-1). Experiment was arranged in a Completely Randomized Design (CRD). Each treatment was repeated five times thus 75 bottles of culture were used; each bottle consists of 5 pieces of leaf cuttings, resulted in total of 375 pieces. The results showed that selection agent had a critical value for Hygromycin 25 mg L-1 and Kanamycin 100 mg L-1 which can make explant experienced necrosis better than Paromomycin. Paromomycin at 100 mg L-1 was only able to kill explant’s periphery. Remained callus stayed fresh more than 50% so that when used as the selection agent could produce more escape cell. The optimum transformation with concentration of 10% Agrobacterium (vol/vol) with 30 minutes co-cultivation can produce more efficient transformed callus. Considering the high price of Hygromycin, it was best to use Kanamycin as selective agents.

  4. Social dilemma structure hidden behind traffic flow with route selection

    NASA Astrophysics Data System (ADS)

    Tanimoto, Jun; Nakamura, Kousuke

    2016-10-01

    Several traffic flows contain social dilemma structures. Herein, we explored a route-selection problem using a cellular automaton simulation dovetailed with evolutionary game theory. In our model, two classes of driver-agents coexist: D agents (defective strategy), which refer to traffic information for route selection to move fast, and C agents (cooperative strategy), which are insensitive to information and less inclined to move fast. Although no evidence suggests that the social dilemma structure in low density causes vehicles to move freely and that in high density causes traffic jams, we found a structure that corresponds to an n-person (multiplayer) Chicken (n-Chicken) game if the provided traffic information is inappropriate. If appropriate traffic information is given to the agents, the n-Chicken game can be solved. The information delivered to vehicles is crucial for easing the social dilemma due to urban traffic congestion when developing technologies to support the intelligent transportation system (ITS).

  5. Production of sintered porous metal fluoride pellets

    DOEpatents

    Anderson, L.W.; Stephenson, M.J.

    1973-12-25

    Porous pellets characterized by a moderately reactive crust and a softer core of higher reactivity are produced by forming agglomerates containing a metal fluoride powder and a selected amount ofwater. The metal fluoride is selected to be sinterable and essentially non-reactive with gaseous fluorinating agents. The agglomerates are contacted with a gaseous fluorinating agent under controlled conditions whereby the heat generated by localized reaction of the agent and water is limited to values effccting bonding by localized sintering. Porous pellets composed of cryolite (Na/sub 3/AlF/sub 6/) can be used to selectively remove trace quantities of niobium pentafluoride from a feed gas consisting predominantly of uranium hexafluoride. (Official Gazette)

  6. Further development of high temperature-resistant graphite fiber coupling agents

    NASA Technical Reports Server (NTRS)

    Griffin, R. N.

    1976-01-01

    Potential coupling agents for graphite fibers were screened by their effect on the weight losses of Thornel 300, HMS, and HTS fibers at 588K for 200 and 400 hours. Unidirectional laminates were made from HMS and HTS fibers, untreated, and treated with each of the seven coupling agents. The matrix of all laminates was PMR polyimide (PMR-PR). On the basis of the best overall retention of elevated temperature interlaminar shear strength after 200 hours at 588K, composite weight after 200 hours at 588K, and fiber weight after 400 hours at 588K, ventromer T-1 applied from aqueous solution and pyrolyzed PPQ were selected for further evaluation as coupling agents for HTS fiber while ventromer T-2 and pyrolyzed PPQ were selected as coupling agents for HMS fiber. It was shown that pyrolyzed PPQ as a coupling agent improves the oxidative stability of HTS/PMR-PI composites.

  7. Department of Defense Federal Hazard Communication Training Program, Trainer’s Guide

    DTIC Science & Technology

    1988-04-01

    Information Tell trainees: Marilyn works as a supervisor in a plant that uses ammonium nitrate to make gun powder and blasting agents. List choices and ask...Continued Marilyn works as a supervisor in a plant that uses ammonium nitrate to make gun powder and blasting agents. 3) What physical hazard is...friend worked twenty years ago for 6 months in a plant where benzidine was used to make dyes. This year, both have developed the same type of bladder

  8. Child Kidnaping. Oversight Hearing Inquiry into the Priorities and Practices of the FBI in Child Kidnaping Cases before the Subcommittee on Juvenile Justice of the Committee on the Judiciary, United States Senate, Ninety-Eighth Congress, First Session (February 2, l983).

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Committee on the Judiciary.

    In questioning priorities of the Subcommittee on Juvenile Justice of the Senate Judiciary Committee, hearings on child kidnaping have established that three elements of a case must exist before agents of the Federal Bureau of Investigation will begin investigations. Federal Kidnaping Statute, Title l8, United States Code, Section 1201 establishes…

  9. Active Labour Market Policy and Gender Mainstreaming in Germany: Gender-Specific Aspects of Participation and Destination in Selected Instruments of the Federal Employment Service. IAB Labour Market Research Topics.

    ERIC Educational Resources Information Center

    Muller, Petra; Kurtz, Beate

    The equality of the opportunities available to males and females in Germany's labor market was examined. The study compared employment patterns among women and men and the extent to which selected discretionary benefits of Germany's Federal Employment Service benefit women and men. Selected results were as follows: (1) women are under-represented…

  10. 40 CFR 272.2251 - Utah State-Administered program: Final authorization.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...: nerve, military, and chemical agents) as more stringent than the Federal rule. To the extent that unused... Wastewaters, Carbamate Wastes, and Spent Potliners (Revision Checklist 151) 61 FR 15566;61 FR 15660; 4/8/96;4...

  11. 40 CFR 272.2251 - Utah State-Administered program: Final authorization.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...: nerve, military, and chemical agents) as more stringent than the Federal rule. To the extent that unused... Wastewaters, Carbamate Wastes, and Spent Potliners (Revision Checklist 151) 61 FR 15566;61 FR 15660; 4/8/96;4...

  12. 40 CFR 272.2251 - Utah State-Administered program: Final authorization.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...: nerve, military, and chemical agents) as more stringent than the Federal rule. To the extent that unused... Wastewaters, Carbamate Wastes, and Spent Potliners (Revision Checklist 151) 61 FR 15566;61 FR 15660; 4/8/96;4...

  13. 40 CFR 272.2251 - Utah State-Administered program: Final authorization.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...: nerve, military, and chemical agents) as more stringent than the Federal rule. To the extent that unused... Wastewaters, Carbamate Wastes, and Spent Potliners (Revision Checklist 151) 61 FR 15566;61 FR 15660; 4/8/96;4...

  14. 78 FR 23204 - Privacy Act of 1974, System of Records

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-18

    ....S.C. 1205-06. (i) Disclosure to a grand jury agent pursuant to a Federal or State grand jury... grand jury. (j) Disclosure in response to a facially valid subpoena for the record. (k) Disclosure to...

  15. [Obesity: a review of currently used antiobesity drugs and new compounds in clinical development].

    PubMed

    Zieba, Remigiusz

    2007-10-19

    This review summarizes data on currently used antiobesity drugs and new compounds under clinical development. Three antiobesity drugs are currently accepted for long-term use. Sibutramine is a noradrenaline and serotonin reuptake inhibitor which reduces body weight by about 4-5 kg but increases heart rate and arterial blood pressure. Orlistat is a gastrointestinal lipase inhibitor which results in mean weight loss by about 3 kg and reduces the incidence of type 2 diabetes in patients with impaired glucose tolerance; however, adverse gastrointestinal effects have been observed. Rimonabant is an endocannabinoid CB1 receptor antagonist which induces a 4-5 kg mean weight loss and improves glycemic and lipid profiles, but it induces anxiety and depressive disorders. Unfortunately, there are no data on the chronic administration of these drugs. Other drugs can induce weight loss, e.g. some antidepressants, antiseizure agents, and antidiabetic drugs. The moderate efficacy of currently used antiobesity drugs has led to an intense effort to identify new, safe antiobesity drugs with better therapeutic profiles. The new antiobesity drugs under clinical development include: 1) agents that affect neurotransmitters in the central nervous system, including noradrenaline and dopamine reuptake inhibitors (bupropion, radafaxine), selective 5HT2C receptor agonists (lorcaserin), and selective 5HT6 receptor antagonists, 2) agents that modulate the activity of neuropeptides influencing food intake, including leptin analogues, human ciliary neurotrophic factor (Axokine), neuropeptide Y antagonists, and melanine-concentrating hormone antagonists, 3) agents that affect the peripheral satiety signals and brain-gut axis, e.g. selective cholecystokinin receptor A agonists, PYY3-36, agents decreasing ghrelin activity, 4) thermogenic agents, e.g. selective beta3 receptor agonists and selective thyroid hormone receptor beta agonists, and 5) others, e.g. human growth hormone fragment (AOD9604) and gastrointestinal lipase inhibitor (cetilistat).

  16. 42 CFR 73.5 - Exemptions for HHS select agents and toxins.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... the select agent or toxin is reported to CDC or APHIS and to other appropriate authorities when... minor (Alastrim), or Yersinia pestis. This report must be followed by submission of APHIS/CDC Form 4.../CDC Form 4 must be submitted within seven calendar days after identification. (iii) Less stringent...

  17. 42 CFR 73.5 - Exemptions for HHS select agents and toxins.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... the select agent or toxin is reported to CDC or APHIS and to other appropriate authorities when... minor (Alastrim), or Yersinia pestis. This report must be followed by submission of APHIS/CDC Form 4.../CDC Form 4 must be submitted within seven calendar days after identification. (iii) Less stringent...

  18. 42 CFR 73.5 - Exemptions for HHS select agents and toxins.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... the select agent or toxin is reported to CDC or APHIS and to other appropriate authorities when... minor (Alastrim), or Yersinia pestis. This report must be followed by submission of APHIS/CDC Form 4.../CDC Form 4 must be submitted within seven calendar days after identification. (iii) Less stringent...

  19. 9 CFR 121.5 - Exemptions for VS select agents and toxins.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Exemptions for VS select agents and toxins. 121.5 Section 121.5 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... toxin that is contained in a specimen presented for proficiency testing will be exempt from the...

  20. 9 CFR 121.5 - Exemptions for VS select agents and toxins.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Exemptions for VS select agents and toxins. 121.5 Section 121.5 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... toxin that is contained in a specimen presented for proficiency testing will be exempt from the...

  1. Double agents and secret agents: the emerging fields of exogenous chemical exchange saturation transfer and T2-exchange magnetic resonance imaging contrast agents for molecular imaging

    PubMed Central

    Daryaei, Iman; Pagel, Mark D

    2016-01-01

    Two relatively new types of exogenous magnetic resonance imaging contrast agents may provide greater impact for molecular imaging by providing greater specificity for detecting molecular imaging biomarkers. Exogenous chemical exchange saturation transfer (CEST) agents rely on the selective saturation of the magnetization of a proton on an agent, followed by chemical exchange of a proton from the agent to water. The selective detection of a biomarker-responsive CEST signal and an unresponsive CEST signal, followed by the ratiometric comparison of these signals, can improve biomarker specificity. We refer to this improvement as a “double-agent” approach to molecular imaging. Exogenous T2-exchange agents also rely on chemical exchange of protons between the agent and water, especially with an intermediate rate that lies between the slow exchange rates of CEST agents and the fast exchange rates of traditional T1 and T2 agents. Because of this intermediate exchange rate, these agents have been relatively unknown and have acted as “secret agents” in the contrast agent research field. This review exposes these secret agents and describes the merits of double agents through examples of exogenous agents that detect enzyme activity, nucleic acids and gene expression, metabolites, ions, redox state, temperature, and pH. Future directions are also provided for improving both types of contrast agents for improved molecular imaging and clinical translation. Therefore, this review provides an overview of two new types of exogenous contrast agents that are becoming useful tools within the armamentarium of molecular imaging. PMID:27747191

  2. Schizophrenia: multi-attribute utility theory approach to selection of atypical antipsychotics.

    PubMed

    Bettinger, Tawny L; Shuler, Garyn; Jones, Donnamaria R; Wilson, James P

    2007-02-01

    Current guidelines/algorithms recommend atypical antipsychotics as first-line agents for the treatment of schizophrenia. Because there are extensive healthcare costs associated with the treatment of schizophrenia, many institutions and health systems are faced with making restrictive formulary decisions regarding the use of atypical antipsychotics. Often, medication acquisition costs are the driving force behind formulary decisions, while other treatment factors are not considered. To apply a multi-attribute utility theory (MAUT) analysis to aid in the selection of a preferred agent among the atypical antipsychotics for the treatment of schizophrenia. Five atypical antipsychotics (risperidone, olanzapine, quetiapine, ziprasidone, aripiprazole) were selected as the alternative agents to be included in the MAUT analysis. The attributes identified for inclusion in the analysis were efficacy, adverse effects, cost, and adherence, with relative weights of 35%, 35%, 20%, and 10%, respectively. For each agent, attribute scores were calculated, weighted, and then summed to generate a total utility score. The agent with the highest total utility score was considered the preferred agent. Aripiprazole, with a total utility score of 75.8, was the alternative agent with the highest total utility score in this model. This was followed by ziprasidone, risperidone, and quetiapine, with total utility scores of 71.8, 69.0, and 65.9, respectively. Olanzapine received the lowest total utility score. A sensitivity analysis was performed and failed to displace aripiprazole as the agent with the highest total utility score. This model suggests that aripiprazole should be considered a preferred agent for the treatment of schizophrenia unless found to be otherwise inappropriate.

  3. Contrast enhanced spectroscopic optical coherence tomography

    NASA Technical Reports Server (NTRS)

    Xu, Chenyang (Inventor); Boppart, Stephen A. (Inventor)

    2010-01-01

    A method of forming an image of a sample includes performing SOCT on a sample. The sample may include a contrast agent, which may include an absorbing agent and/or a scattering agent. A method of forming an image of tissue may include selecting a contrast agent, delivering the contrast agent to the tissue, acquiring SOCT data from the tissue, and converting the SOCT data into an image. The contributions to the SOCT data of an absorbing agent and a scattering agent in a sample may be quantified separately.

  4. 77 FR 36583 - NRC Form 5, Occupational Dose Record for a Monitoring Period

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-19

    ... methods: Federal Rulemaking Web site: Go to http://www.regulations.gov and search for Docket ID NRC-2012... following methods: Federal Rulemaking Web Site: Go to http://www.regulations.gov and search for Docket ID... begin the search, select ``ADAMS Public Documents'' and then select ``Begin Web- based ADAMS Search...

  5. The Subset Sum game.

    PubMed

    Darmann, Andreas; Nicosia, Gaia; Pferschy, Ulrich; Schauer, Joachim

    2014-03-16

    In this work we address a game theoretic variant of the Subset Sum problem, in which two decision makers (agents/players) compete for the usage of a common resource represented by a knapsack capacity. Each agent owns a set of integer weighted items and wants to maximize the total weight of its own items included in the knapsack. The solution is built as follows: Each agent, in turn, selects one of its items (not previously selected) and includes it in the knapsack if there is enough capacity. The process ends when the remaining capacity is too small for including any item left. We look at the problem from a single agent point of view and show that finding an optimal sequence of items to select is an [Formula: see text]-hard problem. Therefore we propose two natural heuristic strategies and analyze their worst-case performance when (1) the opponent is able to play optimally and (2) the opponent adopts a greedy strategy. From a centralized perspective we observe that some known results on the approximation of the classical Subset Sum can be effectively adapted to the multi-agent version of the problem.

  6. The Subset Sum game☆

    PubMed Central

    Darmann, Andreas; Nicosia, Gaia; Pferschy, Ulrich; Schauer, Joachim

    2014-01-01

    In this work we address a game theoretic variant of the Subset Sum problem, in which two decision makers (agents/players) compete for the usage of a common resource represented by a knapsack capacity. Each agent owns a set of integer weighted items and wants to maximize the total weight of its own items included in the knapsack. The solution is built as follows: Each agent, in turn, selects one of its items (not previously selected) and includes it in the knapsack if there is enough capacity. The process ends when the remaining capacity is too small for including any item left. We look at the problem from a single agent point of view and show that finding an optimal sequence of items to select is an NP-hard problem. Therefore we propose two natural heuristic strategies and analyze their worst-case performance when (1) the opponent is able to play optimally and (2) the opponent adopts a greedy strategy. From a centralized perspective we observe that some known results on the approximation of the classical Subset Sum can be effectively adapted to the multi-agent version of the problem. PMID:25844012

  7. Evolutionary game theory using agent-based methods.

    PubMed

    Adami, Christoph; Schossau, Jory; Hintze, Arend

    2016-12-01

    Evolutionary game theory is a successful mathematical framework geared towards understanding the selective pressures that affect the evolution of the strategies of agents engaged in interactions with potential conflicts. While a mathematical treatment of the costs and benefits of decisions can predict the optimal strategy in simple settings, more realistic settings such as finite populations, non-vanishing mutations rates, stochastic decisions, communication between agents, and spatial interactions, require agent-based methods where each agent is modeled as an individual, carries its own genes that determine its decisions, and where the evolutionary outcome can only be ascertained by evolving the population of agents forward in time. While highlighting standard mathematical results, we compare those to agent-based methods that can go beyond the limitations of equations and simulate the complexity of heterogeneous populations and an ever-changing set of interactors. We conclude that agent-based methods can predict evolutionary outcomes where purely mathematical treatments cannot tread (for example in the weak selection-strong mutation limit), but that mathematics is crucial to validate the computational simulations. Copyright © 2016 Elsevier B.V. All rights reserved.

  8. Site Remediation Technology InfoBase: A Guide to Federal Programs, Information Resources, and Publications on Contaminated Site Cleanup Technologies. First Edition

    NASA Technical Reports Server (NTRS)

    1998-01-01

    Table of Contents: Federal Cleanup Programs; Federal Site Remediation Technology Development Assistance Programs; Federal Site Remediation Technology Development Electronic Data Bases; Federal Electronic Resources for Site Remediation Technology Information; Other Electronic Resources for Site Remediation Technology Information; Other Electronic Resources for Site Remediation Technology Information; Selected Bibliography: Federal Publication on Alternative and Innovative Site Remediation; and Appendix: Technology Program Contacts.

  9. INTEROCC case–control study: lack of association between glioma tumors and occupational exposure to selected combustion products, dusts and other chemical agents

    PubMed Central

    2013-01-01

    Background The aim was to investigate possible associations between glioma (an aggressive type of brain cancer) and occupational exposure to selected agents: combustion products (diesel and gasoline exhaust emissions, benzo(a)pyrene), dusts (animal dust, asbestos, crystalline silica, wood dust) and some other chemical agents (formaldehyde, oil mist, sulphur dioxide). Methods The INTEROCC study included cases diagnosed with glioma during 2000–2004 in sub-regions of seven countries. Population controls, selected from various sampling frames in different centers, were frequency or individually matched to cases by sex, age and center. Face-to-face interviews with the subject or a proxy respondent were conducted by trained interviewers. Detailed information was collected on socio-economic and lifestyle characteristics, medical history and work history. Occupational exposure to the 10 selected agents was assessed by a job exposure matrix (JEM) which provides estimates of the probability and level of exposure for different occupations. Using a 25% probability of exposure in a given occupation in the JEM as the threshold for considering a worker exposed, the lifetime prevalence of exposure varied from about 1% to about 15% for the different agents. Associations between glioma and each of the 10 agents were estimated by conditional logistic regression, and using three separate exposure indices: i) ever vs. never; ii) lifetime cumulative exposure; iii) total duration of exposure. Results The study sample consisted of 1,800 glioma cases and 5,160 controls. Most odds ratio estimates were close to the null value. None of the ten agents displayed a significantly increased odds ratio nor any indication of dose–response relationships with cumulative exposure or with duration of exposure. Conclusion Thus, there was no evidence that these exposures influence risk of glioma. PMID:23587105

  10. INTEROCC case-control study: lack of association between glioma tumors and occupational exposure to selected combustion products, dusts and other chemical agents.

    PubMed

    Lacourt, Aude; Cardis, Elisabeth; Pintos, Javier; Richardson, Lesley; Kincl, Laurel; Benke, Geza; Fleming, Sarah; Hours, Martine; Krewski, Daniel; McLean, Dave; Parent, Marie-Elise; Sadetzki, Siegal; Schlaefer, Klaus; Schlehofer, Brigitte; Lavoue, Jerome; van Tongeren, Martie; Siemiatycki, Jack

    2013-04-12

    The aim was to investigate possible associations between glioma (an aggressive type of brain cancer) and occupational exposure to selected agents: combustion products (diesel and gasoline exhaust emissions, benzo(a)pyrene), dusts (animal dust, asbestos, crystalline silica, wood dust) and some other chemical agents (formaldehyde, oil mist, sulphur dioxide). The INTEROCC study included cases diagnosed with glioma during 2000-2004 in sub-regions of seven countries. Population controls, selected from various sampling frames in different centers, were frequency or individually matched to cases by sex, age and center. Face-to-face interviews with the subject or a proxy respondent were conducted by trained interviewers. Detailed information was collected on socio-economic and lifestyle characteristics, medical history and work history. Occupational exposure to the 10 selected agents was assessed by a job exposure matrix (JEM) which provides estimates of the probability and level of exposure for different occupations. Using a 25% probability of exposure in a given occupation in the JEM as the threshold for considering a worker exposed, the lifetime prevalence of exposure varied from about 1% to about 15% for the different agents. Associations between glioma and each of the 10 agents were estimated by conditional logistic regression, and using three separate exposure indices: i) ever vs. never; ii) lifetime cumulative exposure; iii) total duration of exposure. The study sample consisted of 1,800 glioma cases and 5,160 controls. Most odds ratio estimates were close to the null value. None of the ten agents displayed a significantly increased odds ratio nor any indication of dose-response relationships with cumulative exposure or with duration of exposure. Thus, there was no evidence that these exposures influence risk of glioma.

  11. 9 CFR 121.10 - Restricting access to select agents and toxins; security risk assessments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... education, training, and/or experience to handle or use such agents or toxins. (d) To apply for access... other organization that engages in intentional crimes of violence; or being an agent of a foreign power...

  12. 78 FR 17185 - Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-20

    ... Agent Platform, Customer Relationship Management (CRM) and supporting Knowledge Base (KB) solution that... . Follow the instructions for submitting comments. Mail: Federal Docket Management System Office, 2nd Floor.... Title, Associated Form, and OMB Control Number: Customer Care Center Enterprise Solution (CCCES); OMB...

  13. 31 CFR 224.7 - Where can I find a list of United States district court offices?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.7 Where can I find a list of United States district...

  14. 76 FR 8742 - Proposed Information Collection Activity; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-15

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Administration for Children and Families Proposed... the Social Security Act (the Act) to authorize the Secretary, through the Federal Parent Locator... with information maintained by insurers (or their agents) concerning insurance claims, settlements...

  15. 31 CFR 224.7 - Where can I find a list of United States district court offices?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.7 Where can I find a list of United States district...

  16. 31 CFR 224.7 - Where can I find a list of United States district court offices?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.7 Where can I find a list of United States district...

  17. 31 CFR 224.7 - Where can I find a list of United States district court offices?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL PROCESS AGENTS OF SURETY CORPORATIONS § 224.7 Where can I find a list of United States district...

  18. 76 FR 41987 - Interagency Working Group on Coordination of Domestic Energy Development and Permitting in Alaska

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-15

    ... Federal engagement with States, localities, and tribal governments, as it relates to energy development..., employees, or agents, or any other person. (Presidential Sig.) THE WHITE HOUSE, July 12, 2011. [FR Doc. 2011...

  19. Communication Policies in Knowledge Networks

    NASA Astrophysics Data System (ADS)

    Ioannidis, Evangelos; Varsakelis, Nikos; Antoniou, Ioannis

    2018-02-01

    Faster knowledge attainment within organizations leads to improved innovation, and therefore competitive advantage. Interventions on the organizational network may be risky or costly or time-demanding. We investigate several communication policies in knowledge networks, which reduce the knowledge attainment time without interventions. We examine the resulting knowledge dynamics for real organizational networks, as well as for artificial networks. More specifically, we investigate the dependence of knowledge dynamics on: (1) the Selection Rule of agents for knowledge acquisition, and (2) the Order of implementation of "Selection" and "Filtering". Significant decrease of the knowledge attainment time (up to -74%) can be achieved by: (1) selecting agents of both high knowledge level and high knowledge transfer efficiency, and (2) implementing "Selection" after "Filtering" in contrast to the converse, implicitly assumed, conventional prioritization. The Non-Commutativity of "Selection" and "Filtering", reveals a Non-Boolean Logic of the Network Operations. The results demonstrate that significant improvement of knowledge dynamics can be achieved by implementing "fruitful" communication policies, by raising the awareness of agents, without any intervention on the network structure.

  20. Effects of Knowledge, Attitudes, and Practices of Primary Care Providers on Antibiotic Selection, United States

    PubMed Central

    Roberts, Rebecca M.; Albert, Alison P.; Johnson, Darcia D.; Hicks, Lauri A.

    2014-01-01

    Appropriate selection of antibiotic drugs is critical to optimize treatment of infections and limit the spread of antibiotic resistance. To better inform public health efforts to improve prescribing of antibiotic drugs, we conducted in-depth interviews with 36 primary care providers in the United States (physicians, nurse practitioners, and physician assistants) to explore knowledge, attitudes, and self-reported practices regarding antibiotic drug resistance and antibiotic drug selection for common infections. Participants were generally familiar with guideline recommendations for antibiotic drug selection for common infections, but did not always comply with them. Reasons for nonadherence included the belief that nonrecommended agents are more likely to cure an infection, concern for patient or parent satisfaction, and fear of infectious complications. Providers inconsistently defined broad- and narrow-spectrum antibiotic agents. There was widespread concern for antibiotic resistance; however, it was not commonly considered when selecting therapy. Strategies to encourage use of first-line agents are needed in addition to limiting unnecessary prescribing of antibiotic drugs. PMID:25418868

  1. 48 CFR 15.102 - Oral presentations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Oral presentations. 15.102 Section 15.102 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Source Selection Processes and Techniques 15.102 Oral...

  2. 48 CFR 1615.170 - Applicability.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Applicability. 1615.170 Section 1615.170 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES... Source Selection Processes and Techniques. 1615.170 Applicability. FAR subpart 15.1 has no practical...

  3. 48 CFR 2115.170 - Applicability.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Applicability. 2115.170 Section 2115.170 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT, FEDERAL EMPLOYEES... BY NEGOTIATION Source Selection Processes and Techniques 2115.170 Applicability. FAR subpart 15.1 has...

  4. 48 CFR 1615.170 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Applicability. 1615.170 Section 1615.170 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES... Source Selection Processes and Techniques. 1615.170 Applicability. FAR subpart 15.1 has no practical...

  5. 48 CFR 1615.170 - Applicability.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Applicability. 1615.170 Section 1615.170 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES... Source Selection Processes and Techniques 1615.170 Applicability. FAR subpart 15.1 has no practical...

  6. 48 CFR 1615.170 - Applicability.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Applicability. 1615.170 Section 1615.170 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT FEDERAL EMPLOYEES... Source Selection Processes and Techniques 1615.170 Applicability. FAR subpart 15.1 has no practical...

  7. 48 CFR 2115.170 - Applicability.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Applicability. 2115.170 Section 2115.170 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT, FEDERAL EMPLOYEES... BY NEGOTIATION Source Selection Processes and Techniques 2115.170 Applicability. FAR subpart 15.1 has...

  8. 48 CFR 2115.170 - Applicability.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Applicability. 2115.170 Section 2115.170 Federal Acquisition Regulations System OFFICE OF PERSONNEL MANAGEMENT, FEDERAL EMPLOYEES... BY NEGOTIATION Source Selection Processes and Techniques 2115.170 Applicability. FAR subpart 15.1 has...

  9. 48 CFR 16.102 - Policies.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Policies. 16.102 Section 16.102 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Selecting Contract Types 16.102 Policies. (a) Contracts resulting from...

  10. 48 CFR 36.303 - Procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Procedures. 36.303 Section 36.303 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Two-Phase Design-Build Selection Procedures 36.303...

  11. Cavitation-enhanced extravasation for drug delivery.

    PubMed

    Arvanitis, Costas D; Bazan-Peregrino, Miriam; Rifai, Bassel; Seymour, Leonard W; Coussios, Constantin C

    2011-11-01

    A flow-through tissue-mimicking phantom composed of a biocompatible hydro-gel with embedded tumour cells was used to assess and optimize the role of ultrasound-induced cavitation on the extravasation of a macromolecular compound from a channel mimicking vessel in the gel, namely a non-replicating luciferase-expressing adenovirus (Ad-Luc). Using a 500 KHz therapeutic ultrasound transducer confocally aligned with a focussed passive cavitation detector, different exposure conditions and burst mode timings were selected by performing time and frequency domain analysis of passively recorded acoustic emissions, in the absence and in the presence of ultrasound contrast agents acting as cavitation nuclei. In the presence of Sonovue, maximum ultraharmonic emissions were detected for peak rarefactional pressures of 360 kPa, and maximum broadband emissions occurred at 1250 kPa. The energy of the recorded acoustic emissions was used to optimise the pulse repetition frequency and duty cycle in order to maximize either ultraharmonic or broadband emissions while keeping the acoustic energy delivered to the focus constant. Cell viability measurements indicated that none of the insonation conditions investigated induces cell death in the absence of a therapeutic agent (i.e. virus). Phase contrast images of the tissue-mimicking phantom showed that short range vessel disruption can occur when ultra-harmonic emissions (nf0/2) are maximised whereas formation of a micro-channel perpendicular to the flow can be obtained in the presence of broadband acoustic emissions. Following Ad-Luc delivery, luciferase expression measurements showed that a 60-fold increase in its bioavailability can be achieved when broadband noise emissions are present during insonation, even for modest contrast agent concentrations. The findings of the present study suggest that drug delivery systems based on acoustic cavitation may help enhance the extravasation of anticancer agents, thus increasing their penetration distance to hypoxic regions and poorly vascularised tumour regions. Copyright © 2011 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.

  12. 7 CFR 331.3 - PPQ select agents and toxins.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... listed in paragraph (b) of this section if the nucleic acids: (i) Can be expressed in vivo or in vitro; or (ii) Are in a vector or recombinant host genome and can be expressed in vivo or in vitro. (3... select agents and toxins. (a) Except as provided in paragraphs (d) and (e) of this section, the...

  13. A multiplex PCR assay to detect and differentiate select agent strains of Ralstonia solanacearum

    USDA-ARS?s Scientific Manuscript database

    Ralstonia solanacearum causes bacterial wilt in a variety of cash crops. R. solanacearum race 3 biovar 2 strains are considered select agents by the U.S. Government because they are not endemic to the U.S. and have the potential to cause brown rot disease in our potato production fields. Simple and...

  14. The good, the bad, and the timely: how temporal order and moral judgment influence causal selection

    PubMed Central

    Reuter, Kevin; Kirfel, Lara; van Riel, Raphael; Barlassina, Luca

    2014-01-01

    Causal selection is the cognitive process through which one or more elements in a complex causal structure are singled out as actual causes of a certain effect. In this paper, we report on an experiment in which we investigated the role of moral and temporal factors in causal selection. Our results are as follows. First, when presented with a temporal chain in which two human agents perform the same action one after the other, subjects tend to judge the later agent to be the actual cause. Second, the impact of temporal location on causal selection is almost canceled out if the later agent did not violate a norm while the former did. We argue that this is due to the impact that judgments of norm violation have on causal selection—even if the violated norm has nothing to do with the obtaining effect. Third, moral judgments about the effect influence causal selection even in the case in which agents could not have foreseen the effect and did not intend to bring it about. We discuss our findings in connection to recent theories of the role of moral judgment in causal reasoning, on the one hand, and to probabilistic models of temporal location, on the other. PMID:25477851

  15. A Method to Administer Agents to the Larynx in an Awake Large Animal

    ERIC Educational Resources Information Center

    Durkes, Abigail; Sivasankar, M. Preeti

    2017-01-01

    Purpose: This research note describes an adapted experimental methodology to administer an exogenous agent to the larynx and upper airway of awake animals. The exogenous agent could be a perturbation. In the current study, the agent was isotonic saline. Isotonic saline was selected because it is safe, of similar composition to extracellular fluid,…

  16. Hydroxypyridonate chelating agents and synthesis thereof

    DOEpatents

    Raymond, K.N.; Scarrow, R.C.; White, D.L.

    1985-11-12

    Chelating agents having 1-hydroxy-2-pyridinone (HOPO) and related moieties incorporated within their structures, including polydentate HOPO-substituted polyamines such as spermidine and spermine, and HOPO-substituted desferrioxamine. The chelating agents are useful in selectively removing certain cations from solution, and are particularly useful as ferric ion and actinide chelators. Novel syntheses of the chelating agents are provided. 4 tabs.

  17. Effects of Spousal Satisfaction and Selected Career Factors on Job Satisfaction of Extension Agents.

    ERIC Educational Resources Information Center

    Hebert, Michael; Kotrlik, Joe W.

    1990-01-01

    A survey of extension agents and their spouses (n=127, 83 percent) found that the strongest predictor of job satisfaction was spousal satisfaction. Four-H agents had lower job satisfaction, related to long, irregular working hours. Agents had low extrinsic satisfaction related to recognition, salary, policies, and decision-making power. Spouses…

  18. Selected Speeches on Obscenity by Federal Communications Commission Chairman Dean Burch, 1969-74.

    ERIC Educational Resources Information Center

    Hartenberger, Karen Schmidt

    This study is a descriptive/historical account focusing on the obscenity issue and the selected manuscript speeches of Dean Burch while he served as chairman of the Federal Communications Commission (FCC) from October 1969 to March 1974. Research centers on the speaker and the specific manuscript speeches, considering the timeliness and…

  19. Service Delivery to the Handicapped: The Role of the Federal Procurement Process. Part II. Selecting Contractors by Competitive Award.

    ERIC Educational Resources Information Center

    Donaldosn, William S.; Stephens, Thomas M.

    1979-01-01

    Sections address the RFP/IFB (Request for Proposals/Invitation for Bids) process and procedures for selecting the "best" contract. In reviewing the federal procurement code, and the recent decision of the Government Accounting Office, particularly regarding the NIMIS (National Instructional Materials Information System contract), inconsistencies…

  20. Selected Federal Education Programs That Can Help Middle and High School Students Get an Excellent Education

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2006

    2006-01-01

    This document presents a chart titled "Selected Federal Education Programs That Can Help Middle and High School Students Get an Excellent Education." It divides into five columns: (1) "No Child Left Behind" Programs (and Other Reauthorizations); (2) FY 2006 Final Appropriation; (3) FY 2007 Bush Budget; (4) FY 2007 House…

  1. 48 CFR 1336.602-5 - Short selection process for contracts not to exceed the simplified acquisition threshold.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Short selection process for contracts not to exceed the simplified acquisition threshold. 1336.602-5 Section 1336.602-5 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS...

  2. 48 CFR 836.602-5 - Short selection process for contracts not to exceed the simplified acquisition threshold.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Short selection process for contracts not to exceed the simplified acquisition threshold. 836.602-5 Section 836.602-5 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS...

  3. 48 CFR 636.602-5 - Short selection processes for contracts not to exceed the simplified acquisition threshold.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Short selection processes for contracts not to exceed the simplified acquisition threshold. 636.602-5 Section 636.602-5 Federal Acquisition Regulations System DEPARTMENT OF STATE SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS...

  4. 48 CFR 436.602-5 - Short selection process for contracts not to exceed the simplified acquisition threshold.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Short selection process for contracts not to exceed the simplified acquisition threshold. 436.602-5 Section 436.602-5 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS...

  5. 48 CFR 1436.602-5 - Short selection processes for contracts not to exceed the simplified acquisition threshold.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Short selection processes for contracts not to exceed the simplified acquisition threshold. 1436.602-5 Section 1436.602-5 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS...

  6. 48 CFR 736.602-5 - Short selection process for procurements not to exceed the simplified acquisition threshold.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Short selection process for procurements not to exceed the simplified acquisition threshold. 736.602-5 Section 736.602-5 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACT...

  7. 48 CFR 1336.602-5 - Short selection process for contracts not to exceed the simplified acquisition threshold.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Short selection process for contracts not to exceed the simplified acquisition threshold. 1336.602-5 Section 1336.602-5 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS...

  8. 48 CFR 636.602-5 - Short selection processes for contracts not to exceed the simplified acquisition threshold.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Short selection processes for contracts not to exceed the simplified acquisition threshold. 636.602-5 Section 636.602-5 Federal Acquisition Regulations System DEPARTMENT OF STATE SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS...

  9. 48 CFR 1036.602-5 - Short selection process for contracts not to exceed the simplified acquisition threshold.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Short selection process for contracts not to exceed the simplified acquisition threshold. 1036.602-5 Section 1036.602-5 Federal Acquisition Regulations System DEPARTMENT OF THE TREASURY SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS...

  10. 48 CFR 436.602-5 - Short selection process for contracts not to exceed the simplified acquisition threshold.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Short selection process for contracts not to exceed the simplified acquisition threshold. 436.602-5 Section 436.602-5 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS...

  11. 48 CFR 436.602-5 - Short selection process for contracts not to exceed the simplified acquisition threshold.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Short selection process for contracts not to exceed the simplified acquisition threshold. 436.602-5 Section 436.602-5 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS...

  12. 48 CFR 1436.602-5 - Short selection processes for contracts not to exceed the simplified acquisition threshold.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Short selection processes for contracts not to exceed the simplified acquisition threshold. 1436.602-5 Section 1436.602-5 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS...

  13. 48 CFR 736.602-5 - Short selection process for procurements not to exceed the simplified acquisition threshold.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Short selection process for procurements not to exceed the simplified acquisition threshold. 736.602-5 Section 736.602-5 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACT...

  14. 48 CFR 436.602-5 - Short selection process for contracts not to exceed the simplified acquisition threshold.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Short selection process for contracts not to exceed the simplified acquisition threshold. 436.602-5 Section 436.602-5 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS...

  15. 48 CFR 836.602-5 - Short selection process for contracts not to exceed the simplified acquisition threshold.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Short selection process for contracts not to exceed the simplified acquisition threshold. 836.602-5 Section 836.602-5 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS...

  16. 48 CFR 1336.602-5 - Short selection process for contracts not to exceed the simplified acquisition threshold.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Short selection process for contracts not to exceed the simplified acquisition threshold. 1336.602-5 Section 1336.602-5 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS...

  17. 48 CFR 836.602-5 - Short selection process for contracts not to exceed the simplified acquisition threshold.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Short selection process for contracts not to exceed the simplified acquisition threshold. 836.602-5 Section 836.602-5 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS...

  18. 48 CFR 1336.602-5 - Short selection process for contracts not to exceed the simplified acquisition threshold.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Short selection process for contracts not to exceed the simplified acquisition threshold. 1336.602-5 Section 1336.602-5 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS...

  19. 48 CFR 1436.602-5 - Short selection processes for contracts not to exceed the simplified acquisition threshold.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Short selection processes for contracts not to exceed the simplified acquisition threshold. 1436.602-5 Section 1436.602-5 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS...

  20. 48 CFR 636.602-5 - Short selection processes for contracts not to exceed the simplified acquisition threshold.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Short selection processes for contracts not to exceed the simplified acquisition threshold. 636.602-5 Section 636.602-5 Federal Acquisition Regulations System DEPARTMENT OF STATE SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS...

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