TVDG Staff Page

Science.gov Websites

Development, Maintenance & Operation - Computer Hardware & Software No Picture Jim Alessi - Group , Maintenance & Operation No Picture Bob Eich - Accelerator Operator No Picture Irv Feigenbaum (Retired

The Julia sets of basic uniCremer polynomials of arbitrary degree

NASA Astrophysics Data System (ADS)

Blokh, Alexander; Oversteegen, Lex

Let P be a polynomial of degree d with a Cremer point p and no repelling or parabolic periodic bi-accessible points. We show that there are two types of such Julia sets J_P . The red dwarf J_P are nowhere connected im kleinen and such that the intersection of all impressions of external angles is a continuum containing p and the orbits of all critical images. The solar J_P are such that every angle with dense orbit has a degenerate impression disjoint from other impressions and J_P is connected im kleinen at its landing point. We study bi-accessible points and locally connected models of J_P and show that such sets J_P appear through polynomial-like maps for generic polynomials with Cremer points. Since known tools break down for d>2 (if d>2 , it is not known if there are small cycles near p , while if d=2 , this result is due to Yoccoz), we introduce wandering ray continua in J_P and provide a new application of Thurston laminations.

ACHP | Q&A | The ACHP Interview: Dr. Julia King, associate professor of

Science.gov Websites

specific nav links Home arrow The ACHP Interview: Dr. Julia King, associate professor of archaeology and anthropology at St. Mary’s College of Maryland, expert member ACHP The ACHP Interview: Dr. Julia King With the recent Society for Historical Archaeology conference concluded, and former chairman John Nau

Prostate Cancer Research Training Program

DTIC Science & Technology

2009-02-01

Bukola Fatunmbi Katherine Foster Theon Francis Michelle Gray Julia Greenfield Gladys Murage Britanny Stokes Stacy-Ann Wright Lubaroff...Julia Greenfield 2008 Henry Lincoln junior Gladys Murage 2008 Domann Lincoln senior Brittany Stokes 2008 Griffith Lincoln senior Stacy-Ann Wright...report; page 10 Bukola Fatunmbi Katherine Foster Theon Francis Michelle Gray Julia Greenfield Gladys Murage Iowa/Lincoln Summer Research Training

Prostate Cancer Research Training Program

DTIC Science & Technology

2009-06-01

Katherine Foster Theon Francis Michelle Gray Julia Greenfield Gladys Murage Brittany Stokes Stacy-Ann Wright Students Accepted for the 2009...graduate school Michelle Gray 2008 Lubaroff U. Mass Graduate Julia Greenfield 2008 Henry Lincoln Senior Gladys Murage 2008 Domann U. Mass Graduate...Bukola Fatumnbi Michelle Gray 2009 Lincoln Students at the University of Iowa Julia Greenfield Katherine Foster Gladys Murage Stacy-Ann Wright

Protaeolidiella atra Baba, 1955 versus Pleurolidia juliae Burn, 1966: One or two species?

NASA Astrophysics Data System (ADS)

Carmona, Leila; Pola, Marta; Gosliner, Terrence M.; Cervera, Juan Lucas

2015-06-01

Protaeolidiella atra Baba, 1955 and Pleurolidia juliae Burn, 1966 are two species traditionally regarded as the members of Aeolidiidae but recently attributed to Facelinidae. Because of their apparent similarities, Rudman (J Molluscan Stud 56:505-514, 1990) rendered P. juliae as a junior synonym of P. atra. In this paper, we conducted a review of both species and completed their descriptions with new data regarding the anatomy of the reproductive system . P. atra and P. juliae have differences in their colouration, number of cerata and characteristics of their reproductive system. Based on these differences, we conclude that these species are not conspecific and should be regarded as distinct taxa.

Crisis of the Educated Subject: Insight from Kristeva for American Education

ERIC Educational Resources Information Center

Stone, Lynda

2004-01-01

The contemporary crisis in American Education that has resulted in Bush sponsored federal legislation for accountability and standardized testing is the setting for an essay introducing the work of French philosopher, Julia Kristeva. The comparison is between an "educated subject" that might well come to be constituted in schooling at…

NIH Abroad: Pictures Are Crowd Pullers

MedlinePlus

... culture, and the Internet combine to intervene against malaria in Uganda NLM's Julia Royall and Makerere University ... the international team that developed a tutorial on malaria for Africa. Photo courtesy of Julia Royall "Pictures ...

The Multi-Racial School: A Professional Perspective. Penguin Education Specials Series

ERIC Educational Resources Information Center

McNeal, Julia, Ed.; Rogers, Margaret, Ed.

Contents of this anthology of essays by teachers in British multi-racial schools, each of whom deals with a different measure or set of measures which were under- taken to solve the school's problems, as these were defined over time by the head and staff, include: "Foreword," Dipak Nandy; "Introduction," Julia McNeal and…

Evidence of chaotic pattern in solar flux through a reproducible sequence of period-doubling-type bifurcations

NASA Technical Reports Server (NTRS)

Ashrafi, S.; Roszman, L.

1991-01-01

A preliminary study of the limits to solar flux intensity prediction, and of whether the general lack of predictability in the solar flux arises from the nonlinear chaotic nature of the Sun's physical activity is presented. Statistical analysis of a chaotic signal can extract only its most gross features, and detailed physical models fail, since even the simplest equations of motion for a nonlinear system can exhibit chaotic behavior. A recent theory by Feigenbaum suggests that nonlinear systems that can be led into chaotic behavior through a sequence of period-doubling bifurcations will exhibit a universal behavior. As the control parameter is increased, the bifurcation points occur in such a way that a proper ratio of these will approach the universal Feigenbaum number. Experimental evidence supporting the applicability of the Feigenbaum scenario to solar flux data is sparse. However, given the hypothesis that the Sun's convection zones are similar to a Rayleigh-Bernard mechanism, we can learn a great deal from the remarkable agreement observed between the prediction by theory (period doubling - a universal route to chaos) and the amplitude decrease of the signal's regular subharmonics. It is shown that period-doubling-type bifurcation is a possible route to a chaotic pattern of solar flux that is distinguishable from the logarithm of its power spectral density. This conclusion is the first positive step toward a reformulation of solar flux by a nonlinear chaotic approach. The ultimate goal of this research is to be able to predict an estimate of the upper and lower bounds for solar flux within its predictable zones. Naturally, it is an important task to identify the time horizons beyond which predictability becomes incompatible with computability.

Evidence of chaotic pattern in solar flux through a reproducible sequence of period-doubling-type bifurcations

NASA Technical Reports Server (NTRS)

Ashrafi, S.; Roszman, L.

1991-01-01

Presented here is a preliminary study of the limits to solar flux intensity prediction, and of whether the general lack of predictability in the solar flux arises from the nonlinear chaotic nature of the Sun's physical activity. Statistical analysis of a chaotic signal can extract only its most gross features, and detailed physical models fail, since even the simplest equations of motion for a nonlinear system can exhibit chaotic behavior. A recent theory by Feigenbaum suggests that nonlinear systems that can be led into chaotic behavior through a sequence of period-doubling bifurcations will exhibit a universal behavior. As the control parameter is increased, the bifurcation points occur in such a way that a proper ratio of these will approach the universal Feigenbaum number. Experimental evidence supporting the applicability of the Feigenbaum scenario to solar flux data is sparse. However, given the hypothesis that the Sun's convection zones are similar to a Rayleigh-Bernard mechanism, we can learn a great deal from the remarkable agreement observed between the prediction by theory (period doubling - a universal route to chaos) and the amplitude decrease of the signal's regular subharmonics. The authors show that period-doubling-type bifurcation is a possible route to a chaotic pattern of solar flux that is distinguishable from the logarithm of its power spectral density. This conclusion is the first positive step toward a reformulation of solar flux by a nonlinear chaotic approach. The ultimate goal of this research is to be able to predict an estimate of the upper and lower bounds for solar flux within its predictable zones. Naturally, it is an important task to identify the time horizons beyond which predictability becomes incompatible with computability.

QuantumOptics.jl: A Julia framework for simulating open quantum systems

NASA Astrophysics Data System (ADS)

Krämer, Sebastian; Plankensteiner, David; Ostermann, Laurin; Ritsch, Helmut

2018-06-01

We present an open source computational framework geared towards the efficient numerical investigation of open quantum systems written in the Julia programming language. Built exclusively in Julia and based on standard quantum optics notation, the toolbox offers speed comparable to low-level statically typed languages, without compromising on the accessibility and code readability found in dynamic languages. After introducing the framework, we highlight its features and showcase implementations of generic quantum models. Finally, we compare its usability and performance to two well-established and widely used numerical quantum libraries.

First person - Julia Abitbol.

PubMed

2018-05-04

First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Julia Abitbol is the first author on 'Mice harbouring an oculodentodigital dysplasia-linked Cx43 G60S mutation have severe hearing loss', published in Journal of Cell Science. Julia is a PhD student in the lab of Dale Laird at the University of Western Ontario, Canada, investigating the mechanisms of connexin-induced hearing loss. © 2018. Published by The Company of Biologists Ltd.

76 FR 12307 - Texas: Final Authorization of State-initiated Changes and Incorporation by Reference of State...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-07

...: Send written comments to Alima Patterson, Region 6, Regional Authorization Coordinator, or Julia Banks... Federal Register. FOR FURTHER INFORMATION CONTACT: Alima Patterson, (214) 665-8533 and Julia Banks (214...

75 FR 49516 - Lewis and Clark National Wildlife Refuge and the Julia Butler Hansen Refuge for the Columbian...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-13

... that dredge-spoil islands provide benefits for wildlife. Julia Butler Hansen Refuge Alternative 1 Under... safety purposes, studying potential wilderness lands, developing a bicycling and hiking trail, installing...

Bifurcation and Fractal of the Coupled Logistic Map

NASA Astrophysics Data System (ADS)

Wang, Xingyuan; Luo, Chao

The nature of the fixed points of the coupled Logistic map is researched, and the boundary equation of the first bifurcation of the coupled Logistic map in the parameter space is given out. Using the quantitative criterion and rule of system chaos, i.e., phase graph, bifurcation graph, power spectra, the computation of the fractal dimension, and the Lyapunov exponent, the paper reveals the general characteristics of the coupled Logistic map transforming from regularity to chaos, the following conclusions are shown: (1) chaotic patterns of the coupled Logistic map may emerge out of double-periodic bifurcation and Hopf bifurcation, respectively; (2) during the process of double-period bifurcation, the system exhibits self-similarity and scale transform invariability in both the parameter space and the phase space. From the research of the attraction basin and Mandelbrot-Julia set of the coupled Logistic map, the following conclusions are indicated: (1) the boundary between periodic and quasiperiodic regions is fractal, and that indicates the impossibility to predict the moving result of the points in the phase plane; (2) the structures of the Mandelbrot-Julia sets are determined by the control parameters, and their boundaries have the fractal characteristic.

Marketable transport fuels made from Julia Creek shale oil

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1987-03-01

CSR Limited and the CSIRO Division of Energy Chemistry have been working on the problem of producing refined products from the Julia Creek deposit in Queensland, Australia. Two samples of shale oil, retorted at different temperatures from Julia Creek oil shale, were found to differ markedly in aromaticity. Using conventional hydrotreating technology, high quality jet and diesel fuels could be made from the less aromatic oil. Naphtha suitable for isomerization and reforming to gasoline could be produced from both oils. This paper discusses oil properties, stabilization of topped crudes, second stage hydrotreatment, and naphtha hydrotreating. 1 figure, 4 tables.

The National Shipbuilding Research Program. Design for Production Manual 2nd Edition

DTIC Science & Technology

1999-07-01

New York, 1979 Montgomery, Douglas C., Introduction to Statistical Quality Control, 3rd Edition, John Wiley & Sons, New York, 1997 Ishikawa , Kaoru ...references: Feigenbaum, A.V., Total Quality Control: Engineering and Management, 3rd edition, New York McGraw Hill, 1983. Ishikawa , Kaouro., Guide to

A Novel Type of Chaotic Attractor for Quadratic Systems Without Equilibriums

NASA Astrophysics Data System (ADS)

Dantsev, Danylo

In this paper, a new chaotic dynamic system without equilibriums is presented. A conducted research of the qualitative properties of the discovered system reveals a noncompliance between the bifurcation behavior of the system and the Feigenbaum-Sharkovskii-Magnitsky theory. Additional research of known systems confirms the discrepancy.

Becoming Julia

ERIC Educational Resources Information Center

Rosario, Azalea

2013-01-01

This article describes the profound changes experienced by the author during the two years she spent as part of the 52nd Street Project Teen Ensemble, playing the part of "Julia" in Shakespeare's musical play "The Two Gentlemen of Verona." The author reports the difficulty of playing the role, since the character was so…

JuPOETs: a constrained multiobjective optimization approach to estimate biochemical model ensembles in the Julia programming language.

PubMed

Bassen, David M; Vilkhovoy, Michael; Minot, Mason; Butcher, Jonathan T; Varner, Jeffrey D

2017-01-25

Ensemble modeling is a promising approach for obtaining robust predictions and coarse grained population behavior in deterministic mathematical models. Ensemble approaches address model uncertainty by using parameter or model families instead of single best-fit parameters or fixed model structures. Parameter ensembles can be selected based upon simulation error, along with other criteria such as diversity or steady-state performance. Simulations using parameter ensembles can estimate confidence intervals on model variables, and robustly constrain model predictions, despite having many poorly constrained parameters. In this software note, we present a multiobjective based technique to estimate parameter or models ensembles, the Pareto Optimal Ensemble Technique in the Julia programming language (JuPOETs). JuPOETs integrates simulated annealing with Pareto optimality to estimate ensembles on or near the optimal tradeoff surface between competing training objectives. We demonstrate JuPOETs on a suite of multiobjective problems, including test functions with parameter bounds and system constraints as well as for the identification of a proof-of-concept biochemical model with four conflicting training objectives. JuPOETs identified optimal or near optimal solutions approximately six-fold faster than a corresponding implementation in Octave for the suite of test functions. For the proof-of-concept biochemical model, JuPOETs produced an ensemble of parameters that gave both the mean of the training data for conflicting data sets, while simultaneously estimating parameter sets that performed well on each of the individual objective functions. JuPOETs is a promising approach for the estimation of parameter and model ensembles using multiobjective optimization. JuPOETs can be adapted to solve many problem types, including mixed binary and continuous variable types, bilevel optimization problems and constrained problems without altering the base algorithm. JuPOETs is open source, available under an MIT license, and can be installed using the Julia package manager from the JuPOETs GitHub repository.

On the Invariant Cantor Sets of Period Doubling Type of Infinitely Renormalizable Area-Preserving Maps

NASA Astrophysics Data System (ADS)

Lilja, Dan

2018-03-01

Since its inception in the 1970s at the hands of Feigenbaum and, independently, Coullet and Tresser the study of renormalization operators in dynamics has been very successful at explaining universality phenomena observed in certain families of dynamical systems. The first proof of existence of a hyperbolic fixed point for renormalization of area-preserving maps was given by Eckmann et al. (Mem Am Math Soc 47(289):vi+122, 1984). However, there are still many things that are unknown in this setting, in particular regarding the invariant Cantor sets of infinitely renormalizable maps. In this paper we show that the invariant Cantor set of period doubling type of any infinitely renormalizable area-preserving map in the universality class of the Eckmann-Koch-Wittwer renormalization fixed point is always contained in a Lipschitz curve but never contained in a smooth curve. This extends previous results by de Carvalho, Lyubich and Martens about strongly dissipative maps of the plane close to unimodal maps to the area-preserving setting. The method used for constructing the Lipschitz curve is very similar to the method used in the dissipative case but proving the nonexistence of smooth curves requires new techniques.

"Revolution in Religious Language": The Relevance of Julia Kristeva's Theory of "Signifiance" for Theology

ERIC Educational Resources Information Center

Inman, Timothy O.

2017-01-01

This dissertation applies Julia Kristeva's theory of revolution in the practice of "signifiance" to religious discourse. In particular, it argues that the salient features of "signifiance" are present and active in religious speech as well as poetic language, the subject of Kristeva's doctoral thesis "Revolution in Poetic…

Why CCR: A conversation with Physician Assistant Julia Friend | Center for Cancer Research

Cancer.gov

"Where else can you make such a profound difference not only for the individual now, but for those who come in the future? It is hard work, good work and worth doing well.” Physician Assistant Julia Friend answers our questions about why she loves working for CCR. Read more...

Rewriting American Democracy: Language and Cultural (Dis)locations in Esmeralda Santiago and Julia Alvarez

ERIC Educational Resources Information Center

Schultermandl, Silvia

2007-01-01

This article talks about how two American authors of Latin-Caribbean descent, Esmeralda Santiago and Julia Alvarez, inscribe their native language into the discourse of American literature, contributing to a more diverse picture of what American culture is. Thus Alvarez's and Santiago's texts not only renegotiate ethnic immigrant experiences of…

Lorentz violating Julia-Toulouse mechanism

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gaete, Patricio; Wotzasek, Clovis; Instituto de Fisica, Universidade Federal do Rio de Janeiro

2007-03-01

We study a Lorentz invariance violating extension for the pure photonic sector of the standard model. A phenomenological proposal is made for the condensation of topological defects in the presence of a constant rank-m tensor in the context of the Julia-Toulouse mechanism. Possible physical consequences leading to direct measurable effects over the confining properties of the elementary particles are explored.

Dr. Anna Julia Cooper, 1858-1964: Teacher, Scholar, and Timeless Womanist

ERIC Educational Resources Information Center

Giles, Mark S.

2006-01-01

The study examines the various accomplishments and achievements of Dr. Anna Julia Cooper, a social activist-educator, scholar and an early model for African-American feminist theory. Cooper was a great public intellectual and teacher, as she highly attacked the prevalence of racism, sexism and poverty through her writings and by working with…

Randomized, Controlled Trial of CBT Training for PTSD Providers

DTIC Science & Technology

2015-10-01

Wilkinson (Project Manager ), Gayatri Ranganathan , MS (Statistician), Bernet Kato (Statistician), Julia Coleman (Research Associate), Julia Dwyer...I., Friedman, M. J., & Murray, S. (2005). Toward a knowledge management system for posttraumatic stress disorder treatment in veterans healthcare...Secondary Aim #1: To compare improvements in knowledge and attitudes following internet- based training with or without web-centered supervision and

Serving the Needs of Gifted Learners around the Globe: An Interview with Julia Link Roberts

ERIC Educational Resources Information Center

Henshon, Suzanna E.

2018-01-01

Julia Link Roberts is the Mahurin Professor of Gifted Studies at Western Kentucky University (WKU) and the executive director of The Center for Gifted Studies and The Gatton Academy of Mathematics and Science in Kentucky. Dr. Roberts is the president of the World Council for Gifted and Talented Children; current past-president of The Association…

Fermion emission from a Julia-Zee dyon

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blaer, A.S.; Christ, N.H.; Tang, J.

1982-04-15

A relationship is obtained between the S matrix for the charge-exchange scattering of a fermion by a Julia-Zee dyon and the flux of fermions emitted by the dyon when the mass of the fermions is sufficiently small. In the limit of a pointlike dyon, the required S-matrix elements are obtained in closed form and the corresponding fermion flux is computed explicitly.

How Brazil joined the quest for a yellow fever vaccine. Interview by Claudia Jurberg and Julia D'Aloisio..

PubMed

Benchimol, Jaime

2013-03-01

Brazil recently announced an agreement between its Bio-Manguinhos vaccine unit and two US companies to research and develop a new yellow fever vaccine. Claudia Jurberg and Julia D'Aloisio talk to Jaime Benchimol about the controversial history of the development of the vaccine that benefits millions of people today.

African American Women Scholars and International Research: Dr. Anna Julia Cooper's Legacy of Study Abroad

ERIC Educational Resources Information Center

Evans, Stephanie Y.

2009-01-01

EIn this article, the author presents a little-known but detailed history of Black women's tradition of study abroad. Specifically, she situates Dr. Anna Julia Cooper within the landscape of historic African American students who studied in Japan, Germany, Jamaica, England, Italy, Haiti, India, West Africa, and Thailand, in addition to France. The…

In the Service of Neglected People: Anna Julia Cooper, Ontology, and Education

ERIC Educational Resources Information Center

Bonnick, Lemah

2007-01-01

The most influential accounts of Anna Julia Cooper's work have tended to focus on the question of women's equality. In this respect Mary Helen Washington credits Cooper with providing an "embryonic feminist analysis" in the 1890s. The focus of the author is on her understanding of educational matters, which should be seen as a powerful…

End-of-life-vignettes. A Chaplain's story.

PubMed

Bodemann, Christina

2014-03-01

Julia, a 31-year-old woman, is brain dead after having suffered a cardiac arrest. This article describes a hospital chaplain's journey with her family through the tragedy of letting her die. It addresses the power of pastoral presence and prayer in a situation of loss and grief and the importance of storytelling for everyone involved in Julia's end-of-life care.

Contextuality of Young People's Attitudes and Its Implications for Research on Religion: A Response to Julia Ipgrave

ERIC Educational Resources Information Center

Schihalejev, Olga

2012-01-01

This is a response to Julia Ipgrave's contribution on the contextuality of young people's views on religion and religious diversity in this collection of essays on "Religion in Education". First I will highlight and reflect on methodological issues raised by Ipgrave's observations in the light of my own research. The first problem highlighted is…

Pros and Cons of International Weapons Procurement Collaboration.

DTIC Science & Technology

1995-01-01

ad- vanced U.S. industry. Greater risk of cost growth and schedule slippage. Pro: U.S. and partners share common equip- ment. Con : U.S. require...Mark A., 1947- Pros and cons of international weapons procurement collaboration / Mark Lorell, Julia Lowell, p. cm "Prepared for the Office...one/ Cons of International Weapons Procurement Collaboration Mark Lorell Julia Lowell National Defense Research Institute Prepared for the

Research continues on Julia Creek shale oil project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1986-09-01

CSR Limited and the CSIRO Division of Mineral Engineering in Australia are working jointly on the development of a new retorting process for Julia Creek oil shale. This paper describes the retorting process which integrates a fluid bed combustor with a retort in which heat is transferred from hot shale ash to cold raw shale. The upgrading of shale oil into transport fuels is also described.

Education and Access to Christian Thought in the Writing of Harriet Beecher Stowe and Anna Julia Cooper

ERIC Educational Resources Information Center

Magno, JoJo

2009-01-01

In attempting to climb past the racist and sexist barriers which existed in nineteenth-century America, women could look to writers such as Harriet Beecher Stowe and Anna Julia Cooper. Their works not only reflect the conditions of women and African-American women in particular, but also call for access to educational opportunities for these women…

On the dynamics of composition of entire functions

NASA Astrophysics Data System (ADS)

Singh, Anand Prakash

2003-01-01

Let f be an entire function. For n in {bb N}, let f(n) denote the nth iterate of f. The set [ F(f)=\\{z:(f^n) is normal in some neighbourhood of z\\} ] is the Fatou set or the set of normality and its complement J(f) is the Julia set. If U is a component of F(f), then f(U) lies in some component V of F(f). If U_ncap U_m=phi for n ≠ m where U_n denotes the component of F(f) which contains f(n(U)) , then U is called a wandering domain, else U is called a pre-periodic domain, and if U_n = U for some n in {bb N} then U is called periodic domain.

DistributedFBA.jl: High-level, high-performance flux balance analysis in Julia

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heirendt, Laurent; Thiele, Ines; Fleming, Ronan M. T.

Flux balance analysis and its variants are widely used methods for predicting steady-state reaction rates in biochemical reaction networks. The exploration of high dimensional networks with such methods is currently hampered by software performance limitations. DistributedFBA.jl is a high-level, high-performance, open-source implementation of flux balance analysis in Julia. It is tailored to solve multiple flux balance analyses on a subset or all the reactions of large and huge-scale networks, on any number of threads or nodes. DistributedFBA.jl is a high-level, high-performance, open-source implementation of flux balance analysis in Julia. It is tailored to solve multiple flux balance analyses on amore » subset or all the reactions of large and huge-scale networks, on any number of threads or nodes.« less

DistributedFBA.jl: High-level, high-performance flux balance analysis in Julia

DOE PAGES

Heirendt, Laurent; Thiele, Ines; Fleming, Ronan M. T.

2017-01-16

Flux balance analysis and its variants are widely used methods for predicting steady-state reaction rates in biochemical reaction networks. The exploration of high dimensional networks with such methods is currently hampered by software performance limitations. DistributedFBA.jl is a high-level, high-performance, open-source implementation of flux balance analysis in Julia. It is tailored to solve multiple flux balance analyses on a subset or all the reactions of large and huge-scale networks, on any number of threads or nodes. DistributedFBA.jl is a high-level, high-performance, open-source implementation of flux balance analysis in Julia. It is tailored to solve multiple flux balance analyses on amore » subset or all the reactions of large and huge-scale networks, on any number of threads or nodes.« less

Current Sociopolitical, Sociocultural, and Sociolinguistic Issues of Latino Immigrants in Julia Álvarez's Novel "How the García Girls Lost Their Accents"

ERIC Educational Resources Information Center

Molina-Naar, José

2016-01-01

The sociopolitical, sociocultural, and sociolinguistic issues many Latino immigrants face as they embark on the process of adjusting to American society have been depicted by many Hispanic American writers in the United States. Julia Álvarez's "How the García Girls Lost Their Accents" attempts to raise awareness of these issues through…

Of Victorianism, Civilizationism, and Progressivism: The Educational Ideas of Anna Julia Cooper and W.E.B. Du Bois, 1892-1940

ERIC Educational Resources Information Center

Alridge, Derrick P.

2007-01-01

Anna Julia Cooper and W.E.B. Du Bois were two of the most prominent African-American educators of the late 19th and early 20th centuries. During this period, they both envisioned a broad education tailored specifically to the critical intellectual and vocational needs of the entire black community. In this essay, the author examines common themes…

The Battle of Prairie Grove: Civilian Recollections of the Civil War. Teaching with Historic Places.

ERIC Educational Resources Information Center

Montgomery, Don; Baker, Lea Flowers

Julia West was 14 years old when she viewed the carnage and destruction of the battle field at Prairie Grove, Arkansas. She was not the only young spectator at the battle, but she had one of the best views of the conflict. From her home on West Hill (AK), Julia beheld the horror and splendor of battle when the men of the Union Army of the Frontier…

celerite: Scalable 1D Gaussian Processes in C++, Python, and Julia

NASA Astrophysics Data System (ADS)

Foreman-Mackey, Daniel; Agol, Eric; Ambikasaran, Sivaram; Angus, Ruth

2017-09-01

celerite provides fast and scalable Gaussian Process (GP) Regression in one dimension and is implemented in C++, Python, and Julia. The celerite API is designed to be familiar to users of george and, like george, celerite is designed to efficiently evaluate the marginalized likelihood of a dataset under a GP model. This is then be used alongside a non-linear optimization or posterior inference library for the best results.

Accurate 3D Modeling of Breast Deformation for Temporal Mammogram Registration

DTIC Science & Technology

2008-09-01

Julia A. Schnabel, Christine Tanner, Andy D. Castellano Smith, Martin O. Leach, Carmel Hayes, Andreas Degenhard, Rodney Hose, Derek L. G. Hill, and...David J. Hawkes, “Validation of Non- Rigid Registration using Finite Element Methods” [41]. Julia A. Schnabel, Christine Tanner, Andy D. Castellano...IMAGING FOR BREAST CANCER DETECTION Mohammad Alrubaiee, Swapan Kumar Gayen, and Robert R. Alfano City University of New York, City College of New York

Chaotic attractors with separated scrolls

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bouallegue, Kais, E-mail: kais-bouallegue@yahoo.fr

2015-07-15

This paper proposes a new behavior of chaotic attractors with separated scrolls while combining Julia's process with Chua's attractor and Lorenz's attractor. The main motivation of this work is the ability to generate a set of separated scrolls with different behaviors, which in turn allows us to choose one or many scrolls combined with modulation (amplitude and frequency) for secure communication or synchronization. This set seems a new class of hyperchaos because each element of this set looks like a simple chaotic attractor with one positive Lyapunov exponent, so the cardinal of this set is greater than one. This newmore » approach could be used to generate more general higher-dimensional hyperchaotic attractor for more potential application. Numerical simulations are given to show the effectiveness of the proposed theoretical results.« less

Total Quality Management Guide. Volume 2. A Guide to Implementation

DTIC Science & Technology

1990-02-15

Kaoru . Guide to Quality Control. Asian Productivity Organization. 1984. Ishikawa , Kaoru . What is Total Quality Control? The Japanese Way. Englewood...of the new Systems Age. The theories of Deming, Juran, Ishikawa , and other management methods that still predominate are pioneers of Systems Age...Feigenbaum, Armand V. Total Quality Control. New York: McGraw-Hill Book Company. 1983. bnai, Masaaki. Kaizen. New York: Random House. 1986. Ishikawa

TQM - Total Quality Management (Bibliography)

DTIC Science & Technology

1990-05-01

ISBN: 0-941893-00-6 Price: $27.00 NAVSWC Library Call No: TS156 S358 GUIDE TO OUALITY CONTROL Author: Ishikawa , Kaoru Publisher: Asian Productivity...teachings of Juran, Deming, Feigenbaum, Crosby, Taguchi, Shewhart, Ishikawa , and others. 19 OUT OF BEDLAM: MANAGEMENT BY QUALITY LEADERSHIP Author...Price: $60.00 WHAT IS TOTAL QUALITY CONTROL? THE JAPANESE WAY Author. Ishikawa , K oru Publisher: Prentice Hall Date: 1985 Pagination: 215pp ISBN: 0-13

An Integrated Research Program for the Modeling, Analysis and Control of Aerospace Systems

DTIC Science & Technology

1992-03-03

Fabiano, Jr. - Brown University Mitchell Feigenbaum - Rockefeller University Elena Fernandez - Institudo de Desarrollo Techologico, para la Industria...system. The system runs under DEC Ultrix; we have installed the GKS graphics system and language compilers (FORTRAN and C). The DELIGHT.MIMO software ...which links a sophisticated non-smooth optimization package to some linear system software , is on the system. The package was kindly furnished by

An Integrated Research Program for the Modeling, Analysis and Control of Aerospace Systems

DTIC Science & Technology

1992-03-03

Mitchell Feigenbaum - Rockefeller University Elena Fernandez - Institudo de Desarrollo Techologico, para la Industria Quimica Wilfred M. Greenlee...Ultrix; we have installed the GKS graphics system and language compilers (FORTRAN and C). The DELIGHT.MIMO software , which links a sophisticated non...smooth optimization package to some linear system software , is on the system. The package was kindly furnished by Professor E. Polak, Electrical and

On swinging spring chaotic oscillations

NASA Astrophysics Data System (ADS)

Aldoshin, Gennady T.; Yakovlev, Sergey P.

2018-05-01

In this work, chaotic modes of Swinging spring oscillations, their appearing conditions and probable scenario of evolution are studied. Swinging spring two-dimensional potential has (under certain conditions) local maximum. It can lead to stochastic attractor appearing. The system instability reason is inner (auto-parametric) resonance with frequencies ratio 2:1, which allows us to conclude that attractor could evolve according to the period doubling scenario, which was predicted by Feigenbaum in 1978.

Process concept of retorting of Julia Creek oil shale

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sitnai, O.

1984-06-01

A process is proposed for the above ground retorting of the Julia Creek oil shale in Queensland. The oil shale characteristics, process description, chemical reactions of the oil shale components, and the effects of variable and operating conditions on process performance are discussed. The process contains a fluidized bed combustor which performs both as a combustor of the spent shales and as a heat carrier generator for the pyrolysis step. 12 references, 5 figures, 5 tables.

Symposium Registration | The Metastatic Niche: Models, Mechanisms and Targeting Targets into Therapeutics

Cancer.gov

Symposium Registration Register for the meeting and abstract submission. Registration for the meeting is required and registration is free. ONLINE REGISTRATION IS CLOSED. Please contact Julia E. Lam (Julia.Lam@nih.gov) if you want to register to attend this event. Abstracts should be submitted at the time of registration and a limited number will be selected for oral presentation and the remainder for poster presentation.   Abstract Submission Deadline is February 21st 2017.

Total Quality Management: Implications for Nursing Information Systems

DTIC Science & Technology

1992-01-01

the Defense Department’s TQM model (see Appendix M) and TQM master plan (see Appendix N) (Hunt, 1992). Ishikawa . Kaoru Ishikawa was the best known of...the subject -- Deming, Juran, Crosby, Feigenbaum, Ishikawa , etc. (see Chapter 2). One of the most concise definitions on TQM was given in a speech by...with the contributions of key quality authors, including Deming, Juran, Crosby, Costello, and Ishikawa . The use of TQM in business and in healthcare

Statistics of Mass Production

DTIC Science & Technology

1993-05-01

smaller ones, and the second after Kaoru Ishikawa who developed it in 1943. 22 UCL LCL Sample number Sample numbe CYCLES ON A CONTROL CHART A SHIFT IN...include Phillip Crosby, W. Edwards Deming, Armand Feigenbaum, Kaoru Ishikawa , and Joseph Juran. As an example of the ideas, the well-known 14 points of...tool for analyzing process dispersion. It is also referred to as the Ishikawa diagram, because Kaoru Ishikawa developed it, and the fishbone diagram

Fuzzy fractals, chaos, and noise

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zardecki, A.

1997-05-01

To distinguish between chaotic and noisy processes, the authors analyze one- and two-dimensional chaotic mappings, supplemented by the additive noise terms. The predictive power of a fuzzy rule-based system allows one to distinguish ergodic and chaotic time series: in an ergodic series the likelihood of finding large numbers is small compared to the likelihood of finding them in a chaotic series. In the case of two dimensions, they consider the fractal fuzzy sets whose {alpha}-cuts are fractals, arising in the context of a quadratic mapping in the extended complex plane. In an example provided by the Julia set, the conceptmore » of Hausdorff dimension enables one to decide in favor of chaotic or noisy evolution.« less

E- or Z-Selective synthesis of 4-fluorovinyl-1,2,3-triazoles with fluorinated second-generation Julia-Kocienski reagents.

PubMed

Kumar, Rakesh; Singh, Govindra; Todaro, Louis J; Yang, Lijia; Zajc, Barbara

2015-02-07

A highly modular approach to N-substituted 4-(1-fluorovinyl)triazoles is described. In situ desilylation and Cu-catalyzed ligation reaction of TMS-protected α-fluoropropargyl benzothiazole sulfone with aryl, alkyl, and metallocenyl azides furnished second-generation Julia-Kocienski reagents in good to excellent yields. Condensation reactions of these reagents with aldehydes can be tuned to yield E or Z-alkenes selectively. Under mild conditions with DBU as the base, reactions of aldehydes furnished E-alkenes as the major isomer. On the other hand, in condensation reactions with LHMDS as the base and in appropriate solvents, both aldehydes and ketones reacted to yield fluoroalkenes with Z-selectivity. Stereochemical assignment of E/Z olefins obtained in the reaction of a ketone with two Julia reagents was performed via X-ray crystallographic analysis and comparisons of NMR data. The method allows efficient and ready diversification of the N1-substituent and substituents at the double bond.

E- or Z-selective synthesis of 4-fluorovinyl-1,2,3-triazoles with fluorinated second-generation Julia-Kocienski reagents

PubMed Central

Kumar, Rakesh; Singh, Govindra; Todaro, Louis J.; Yang, Lijia; Zajc, Barbara

2016-01-01

A highly modular approach to N-substituted 4-(1-fluorovinyl)triazoles is described. In situ desilylation and Cu-catalyzed ligation reaction of TMS-protected α-fluoropropargyl benzothiazole sulfone with aryl, alkyl, and metallocenyl azides furnished second-generation Julia-Kocienski reagents in good to excellent yields. Condensation reactions of these reagents with aldehydes can be tuned to yield E or Z-alkenes selectively. Under mild conditions with DBU as base, reactions of aldehydes furnished E-alkenes as the major isomer. On the other hand, in condensations with LHMDS as base and in appropriate solvents, both aldehydes and ketones reacted to yield fluoroalkenes with Z-selectivity. Stereochemical assignment to E/Z olefins obtained in the reaction of a ketone with two Julia reagents was performed via X-ray crystallographic analysis and comparisons of NMR data. The method allows efficient and ready diversification of N1-substituent and substituents at the double bond. PMID:25491086

gem-Difluoroolefination of diaryl ketones and enolizable aldehydes with difluoromethyl 2-pyridyl sulfone: new insights into the Julia-Kocienski reaction.

PubMed

Gao, Bing; Zhao, Yanchuan; Hu, Mingyou; Ni, Chuanfa; Hu, Jinbo

2014-06-16

The direct conversion of diaryl ketones and enolizable aliphatic aldehydes into gem-difluoroalkenes has been a long-standing challenge in organofluorine chemistry. Herein, we report efficient strategies to tackle this problem by using difluoromethyl 2-pyridyl sulfone as a general gem-difluoroolefination reagent. The gem-difluoroolefination of diaryl ketones proceeds by acid-promoted Smiles rearrangement of the carbinol intermediate; the gem-difluoroolefination is otherwise difficult to achieve through a conventional Julia-Kocienski olefination protocol under basic conditions due to the retro-aldol type decomposition of the key intermediate. Efficient gem-difluoroolefination of aliphatic aldehydes was achieved by the use of an amide base generated in situ (from CsF and tris(trimethylsilyl)amine), which diminishes the undesired enolization of aliphatic aldehydes and provides a powerful synthetic method for chemoselective gem-difluoroolefination of multi-carbonyl compounds. Our results provide new insights into the mechanistic understanding of the classical Julia-Kocienski reaction. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

A multifractal analysis of equilibrium measures for conformal expanding maps and Moran-like geometric constructions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pesin, Y.; Weiss, H.

1997-01-01

In this paper we establish the complete multifractal formalism for equilibrium measures for Holder continuous conformal expanding maps and expanding Markov Moran-like geometric constructions. Examples include Markov maps of an interval, beta transformations of an interval, rational maps with hyperbolic Julia sets, and conformal total endomorphisms. We also construct a Holder continuous homeomorphism of a compact metric space with an ergodic invariant measure of positive entropy for which the dimension spectrum is not convex, and hence the multifractal formalism fails.

Boris Novozhilov: Life and contribution to the physics of combustion

NASA Astrophysics Data System (ADS)

Novozhilov, Vasily

2018-04-01

Professor Boris Novozhilov (1930-2017) passed away on February 19th, 2017 in Moscow. The present paper provides brief account of his life and contributions to the physics of combustion. From extensive scientific legacy left by Boris, several major achievements are discussed here: Zeldovich-Novozhilov (ZN) theory of unsteady solid propellant combustion, contributions to thermal explosion theory, the theory of spin combustion, discovery of propellant combustion transition to chaotic regimes through Feigenbaum period bifurcation scenario.

Analysis of pigments from Roman wall paintings found in the "agro centuriato" of Julia Concordia (Italy).

PubMed

Mazzocchin, Gian-Antonio; Del Favero, Michela; Tasca, Giovanni

2007-09-01

The analysis of wall painting fragments recovered in the "agro centuriato" of Julia Concordia has been carried out by using Scanning Electron Microscopy equipped with an EDS microanalysis detector (SEM-EDS), Infrared Spectroscopy (FTIR) and X-Ray powder Diffraction (XRD). The pigments used have been identified and the data obtained suggest the presence of three rustic villas richly decorated also with Egyptian blue. The presence of white of aragonite suggest that these villas were decorated during the Imperial Age, in agreement with the recovery of high quality materials and a bronze statue.

Multidisciplinary approach for fault detection: Integration of PS-InSAR, geomorphological, stratigraphic and structural data in the Venafro intermontane basin (Central-Southern Apennines, Italy)

NASA Astrophysics Data System (ADS)

Amato, Vincenzo; Aucelli, Pietro P. C.; Bellucci Sessa, Eliana; Cesarano, Massimo; Incontri, Pietro; Pappone, Gerardo; Valente, Ettore; Vilardo, Giuseppe

2017-04-01

A multidisciplinary methodology, integrating stratigraphic, geomorphological and structural data, combined with GIS-aided analysis and PS-InSAR interferometric data, was applied to characterize the relationships between ground deformations and the stratigraphic and the morphostructural setting of the Venafro intermontane basin. This basin is a morphostructural depression related to NW-SE and NE-SW oriented high angle normal faults bordering and crossing it. In particular, a well-known active fault crossing the plain is the Aquae Juliae Fault, whose recent activity is evidenced by archeoseismological data. The approach applied here reveals new evidence of possible faulting, acting during the Lower to Upper Pleistocene, which has driven the morphotectonic and the environmental evolution of the basin. In particular, the tectonic setting emerging from this study highlights the influence of the NW-SE oriented extensional phase during the late Lower Pleistocene - early Middle Pleistocene, in the generation of NE-SW trending, SE dipping, high-angle faults and NW-SE trending, high-angle transtensive faults. This phase has been followed by a NE-SW extensional one, responsible for the formation of NW-SE trending, both NW and SE dipping, high-angle normal faults, and the reactivation of the oldest NE-SW oriented structures. These NW-SE trending normal faults include the Aquae Juliae Fault and a new one, unknown until now, crossing the plain between the Venafro village and the Colle Cupone Mt. (hereinafter named the Venafro-Colle Cupone Fault, VCCF). This fault has controlled deposition of the youngest sedimentary units (late Middle Pleistocene to late Upper Pleistocene) suggesting its recent activity and it is well constrained by PS-InSAR data, as testified by the increase of the subsidence rate in the hanging wall block.

Web-based workflows to produce ocean climatologies using DIVA (Data-Interpolating Variational Analysis) and Jupyter notebooks

NASA Astrophysics Data System (ADS)

Barth, Alexander; Troupin, Charles; Watelet, Sylvain; Alvera-Azcarate, Aida; Beckers, Jean-Marie

2017-04-01

The analysis tool DIVA (Data-Interpolating Variational Analysis) is designed to generate gridded fields or climatologies from in situ observations. The tool DIVA minimizes a cost function to ensure that the analysed field is relatively close to the observations and conforms at the same time to a set of dynamical constraints. In particular, DIVA naturally decouples water bodies which are not directly connected and it uses a (potentially spatial varying) correlation length to describe over which length-scale the analysed variable is correlated. In addition, DIVA can also take ocean currents into account to introduce a preferential direction for the correlation. The SeaDataCloud project aims to facilitate the access and use of ocean in situ data from 45 national oceanographic data centres and marine data centres from 35 countries riparian to all European seas. A central aspect is to provide web-based virtual research environment, where scientists can easily access and explore the data sets through the SeaDataCloud infrastructure. For users familiar with programming languages like Julia and Python, Jupyter (acronym for Julia, Python and R) notebooks provide an exciting way to analyse and to interact with ocean data. Jupyter notebooks are made up of cells that can be run individually and can contain text, formulas or code fragment. A complete notebook explains how to go from input data and parameters to a result, in this case a gridded field obtained executing DIVA. This presentation discusses this new web-based workflow for generating climatologies using DIVA. It explores its new possibilities in particular, in terms of improved ease of use and reproducibility of the results. The integration in the infrastructure of EUDAT is also addressed.

Simulations of Stagewise Development with a Symbolic Architecture

NASA Astrophysics Data System (ADS)

Gobet, Fernand

This chapter compares Piaget's theory of development with Feigenbaum & Simon's (1962; 1984) EPAM theory. An attempt is made to map the concepts of assimilation and accommodation in Piaget's theory onto the concepts of familiarisation and accommodation in EPAM. An EPAM-like model of the balance scale task is then presented, with a discussion of preliminary results showing how it accounts for children's discontinuous, stage-like development. The analysis focuses on the transition between rules, using catastrophe flags (Gilmore, 1981) as criteria. It is argued that some symbolic models may be described as dynamical systems, in the same way as some non-symbolic models.

A nonlinear dynamical system for combustion instability in a pulse model combustor

NASA Astrophysics Data System (ADS)

Takagi, Kazushi; Gotoda, Hiroshi

2016-11-01

We theoretically and numerically study the bifurcation phenomena of nonlinear dynamical system describing combustion instability in a pulse model combustor on the basis of dynamical system theory and complex network theory. The dynamical behavior of pressure fluctuations undergoes a significant transition from steady-state to deterministic chaos via the period-doubling cascade process known as Feigenbaum scenario with decreasing the characteristic flow time. Recurrence plots and recurrence networks analysis we adopted in this study can quantify the significant changes in dynamic behavior of combustion instability that cannot be captured in the bifurcation diagram.

Using Peano Curves to Construct Laplacians on Fractals

NASA Astrophysics Data System (ADS)

Molitor, Denali; Ott, Nadia; Strichartz, Robert

2015-12-01

We describe a new method to construct Laplacians on fractals using a Peano curve from the circle onto the fractal, extending an idea that has been used in the case of certain Julia sets. The Peano curve allows us to visualize eigenfunctions of the Laplacian by graphing the pullback to the circle. We study in detail three fractals: the pentagasket, the octagasket and the magic carpet. We also use the method for two nonfractal self-similar sets, the torus and the equilateral triangle, obtaining appealing new visualizations of eigenfunctions on the triangle. In contrast to the many familiar pictures of approximations to standard Peano curves, that do no show self-intersections, our descriptions of approximations to the Peano curves have self-intersections that play a vital role in constructing graph approximations to the fractal with explicit graph Laplacians that give the fractal Laplacian in the limit.

Drusus sharrensis sp. n. (Trichoptera, Limnephilidae), a new species from Sharr National Park in Kosovo, with molecular and ecological notes

PubMed Central

Ibrahimi, Halil; Vitecek, Simon; Previšić, Ana; Kučinić, Mladen; Johann Waringer; Graf, Wolfram; Balint, Miklós; Keresztes, Lujza; Pauls, Steffen U.

2016-01-01

Abstract In this paper we describe Drusus sharrensis sp. n., from the Sharr Mountains in Kosovo. Males of the new species are morphologically most similar to Drusus krusniki Malicky, 1981, Drusus kerek Oláh, 2011 and Drusus juliae Oláh, 2011 but differ mainly in exhibiting (1) a differently shaped spinose area on tergite VIII; (2) intermediate appendages anteriorly curved in lateral view with broad tips in dorsal view; (3) inferior appendages with a distinct dorsal protrusion in the proximal half. Females of the new species are morphologically most similar to Drusus krusniki, Drusus kerek, Drusus juliae, and Drusus plicatus Radovanovic, 1942 but mainly differ in (1) segment X that is longer than the supragenital plate with distinctly pointed tips; (2) supragenital plate quadrangular with a distinct round dorsal protrusion; (3) a vulvar scale with a small median lobe. Results of phylogenetic species delimitation support monophyly of Drusus sharrensis sp. n. and recover it as sister to a clade comprising (Drusus pelasgus Oláh, 2010 + Drusus juliae + Drusus arbanios Oláh, 2010 + Drusus plicatus + (Drusus dacothracus Oláh, 2010 + Drusus illyricus Oláh, 2010)). The new species is a micro-endemic of the Sharr Mountains, a main biodiversity hotspot in the Balkan Peninsula. Main threats to the aquatic ecosystems of this part of the Balkan Peninsula are discussed. PMID:27006607

A Computationally Efficient Parallel Levenberg-Marquardt Algorithm for Large-Scale Big-Data Inversion

NASA Astrophysics Data System (ADS)

Lin, Y.; O'Malley, D.; Vesselinov, V. V.

2015-12-01

Inverse modeling seeks model parameters given a set of observed state variables. However, for many practical problems due to the facts that the observed data sets are often large and model parameters are often numerous, conventional methods for solving the inverse modeling can be computationally expensive. We have developed a new, computationally-efficient Levenberg-Marquardt method for solving large-scale inverse modeling. Levenberg-Marquardt methods require the solution of a dense linear system of equations which can be prohibitively expensive to compute for large-scale inverse problems. Our novel method projects the original large-scale linear problem down to a Krylov subspace, such that the dimensionality of the measurements can be significantly reduced. Furthermore, instead of solving the linear system for every Levenberg-Marquardt damping parameter, we store the Krylov subspace computed when solving the first damping parameter and recycle it for all the following damping parameters. The efficiency of our new inverse modeling algorithm is significantly improved by using these computational techniques. We apply this new inverse modeling method to invert for a random transitivity field. Our algorithm is fast enough to solve for the distributed model parameters (transitivity) at each computational node in the model domain. The inversion is also aided by the use regularization techniques. The algorithm is coded in Julia and implemented in the MADS computational framework (http://mads.lanl.gov). Julia is an advanced high-level scientific programing language that allows for efficient memory management and utilization of high-performance computational resources. By comparing with a Levenberg-Marquardt method using standard linear inversion techniques, our Levenberg-Marquardt method yields speed-up ratio of 15 in a multi-core computational environment and a speed-up ratio of 45 in a single-core computational environment. Therefore, our new inverse modeling method is a powerful tool for large-scale applications.

Metal speciation in Julia Creek oil shale

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hirner, A.V.

1989-03-01

The concentrations of 19 elements were determined in organic and inorganic phases of the Julia Creek Oil Shale (Queensland/Australia). The phases were obtained by solvent and alkaline extractions as well as by stepwise demineralization with strong acids. Together with the results of other groups, a consistent model concerning the partition of trace elements in the various sedimentary components could be achieved. Whereas V, Ni and Ag show distributions comparable to the abundances of the correspondent phases in the sample, Ca, Mn and Co are concentrated in the mineral components, and B, As and Pb are enriched in kerogen. Al, Cr,more » Fe, Cu, Zn, Mo, Cd and Sb range between these extremes, while Au and Hg are contained in the humic substances only.« less

ARC-2013-ACD13-0044-002

NASA Image and Video Library

2013-03-12

Women Fly it forward event at Hiller Aviation. Aisha Bowe (right) with Ames Navigation, Guidance & Control Systems Branch reaches out to Julia Smith (left) and Taylor Grafstrom (center) about women in aviation.

100 History-Making Ethnic Women

ERIC Educational Resources Information Center

York, Sherry

2004-01-01

A list of hundred history-making ethnic women who have created history in their respective fields and become successful writers is presented. The list includes Alma Flor Ada, Julia Alvarez and Oprah Winfrey.

Curing Children's Cancer

MedlinePlus

... Madelen, after chemotherapy. Her parents, father José and mother Julia, say, "Nobody wants to be in this ... friends easily, even with the shyest kids. They love to play together at The Children's Inn at ...

More Lessons From Complexity

NASA Astrophysics Data System (ADS)

Puente, C. E.

2002-12-01

The last few decades have witnessed the development of a host of ideas aimed at understanding and predicting nature's ever present complexity. It is shown that such a work provides, through its detailed study of order and disorder, a suitable framework for visualizing the dynamics and consequences of mankind's ever present divisive traits. Specifically, this article explains how recent universal results pertaining to the transition from order to chaos via a cascade of bifurcations point us to a serene state, symbolized by the convergence to the origin in the root of a Feigenbaum's tree, in which we all may achieve our inherently desired condition of justice and peace.

Teaching Writing on the Shoulders of Giants.

ERIC Educational Resources Information Center

Jensen, Julie M.

2002-01-01

Presents descriptions of influential individuals who have shaped language arts education as it is know today. Elaborates on contributions of: Sylvia Ashton-Warner; Natalie Robinson Cole; Julia Weber Gordon; and Alvina Treut Burrows. (SG)

Mads.jl

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vesselinov, Velimir; O'Malley, Daniel; Lin, Youzuo

2016-07-01

Mads.jl (Model analysis and decision support in Julia) is a code that streamlines the process of using data and models for analysis and decision support. It is based on another open-source code developed at LANL and written in C/C++ (MADS; http://mads.lanl.gov; LA-CC-11- 035). Mads.jl can work with external models of arbitrary complexity as well as built-in models of flow and transport in porous media. It enables a number of data- and model-based analyses including model calibration, sensitivity analysis, uncertainty quantification, and decision analysis. The code also can use a series of alternative adaptive computational techniques for Bayesian sampling, Monte Carlo,more » and Bayesian Information-Gap Decision Theory. The code is implemented in the Julia programming language, and has high-performance (parallel) and memory management capabilities. The code uses a series of third party modules developed by others. The code development will also include contributions to the existing third party modules written in Julia; this contributions will be important for the efficient implementation of the algorithm used by Mads.jl. The code also uses a series of LANL developed modules that are developed by Dan O'Malley; these modules will be also a part of the Mads.jl release. Mads.jl will be released under GPL V3 license. The code will be distributed as a Git repo at gitlab.com and github.com. Mads.jl manual and documentation will be posted at madsjulia.lanl.gov.« less

Julia Carson Responsible Fatherhood and Healthy Families Act of 2009

THOMAS, 111th Congress

Rep. Davis, Danny K. [D-IL-7

2009-06-19

House - 06/18/2010 Referred to the Subcommittee on Department Operations, Oversight, Nutrition and Forestry. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

76 FR 77247 - Lewis and Clark National Wildlife Refuge and Julia Butler Hansen Refuge for the Columbian White...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-12

... wilderness designation proposal, and work with partners to ensure that dredge-spoil islands provide benefits..., studying potential wilderness lands, developing a bicycling and hiking trail, installing interpretive...

75 FR 47256 - Louisiana: Final Authorization of State-Initiated Changes and Incorporation by Reference of State...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-05

..., 2010. ADDRESSES: Send written comments to Alima Patterson, Region 6, Regional Authorization Coordinator... Federal Register. FOR FURTHER INFORMATION CONTACT: Alima Patterson or Julia Banks at (214) 665-8533 or...

77 FR 71395 - Texas: Final Authorization of State-initiated Changes and Incorporation by Reference of State...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-30

.... ADDRESSES: Send written comments to Alima Patterson, Region 6, Regional Authorization Coordinator, or Julia... located in the Rules section of this Federal Register. FOR FURTHER INFORMATION CONTACT: Alima Patterson...

Victorian spectacle: Julia Pastrana, the bearded and hairy female.

PubMed

Browne, Janet; Messenger, Sharon

2003-12-01

Julia Pastrana toured Europe in the late 1850s advertising herself as the 'Bearded and hairy Lady' or 'Nonedescript'. She suffered from a rare inherited disorder, not understood until the late 20th century, which manifested itself in facial distortion and considerable facial hair in the male pattern. Doctors, as well as sensation seekers, were very keen to examine her. Her story is unusual, not least because she was mummified after death by her husband-manager and continued to tour as a mounted exhibit for a number of decades. Indirectly, she participated in the evolutionary debate in Britain. In 1857, when she arrived in Britain from America, she was popularly known as the baboon-woman. When Darwin's Origin of Species was published, and evolutionary controversy about ape-ancestry was hot in the air, she was more often likened to the gorilla or orang-utan - as a possible specimen of a missing link.

Universal renormalization-group dynamics at the onset of chaos in logistic maps and nonextensive statistical mechanics

NASA Astrophysics Data System (ADS)

Baldovin, F.; Robledo, A.

2002-10-01

We uncover the dynamics at the chaos threshold μ∞ of the logistic map and find that it consists of trajectories made of intertwined power laws that reproduce the entire period-doubling cascade that occurs for μ<μ∞. We corroborate this structure analytically via the Feigenbaum renormalization-group (RG) transformation and find that the sensitivity to initial conditions has precisely the form of a q exponential, of which we determine the q index and the q-generalized Lyapunov coefficient λq. Our results are an unequivocal validation of the applicability of the nonextensive generalization of Boltzmann-Gibbs statistical mechanics to critical points of nonlinear maps.

Reforming the American Military Officer Personnel System

DTIC Science & Technology

2015-12-02

Lamping Lewis, Henry Leonard, Julia Pollak, Christopher Guo and Bernard Rostker, Tour Lengths, Permanent Changes of Station, and Alternatives for...Raymond E. Conley, Stephanie Young, William A. Williams, Jeffrey Engstrom, Barbara Bicksler, Sara Beth Elson, Joseph Jenkins , Lianne Kennedy

76 FR 41755 - Eastern Arizona Counties Resource Advisory; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-15

... DEPARTMENT OF AGRICULTURE Forest Service Eastern Arizona Counties Resource Advisory; Meeting AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Eastern Arizona Counties Resource... FURTHER INFORMATION CONTACT: Julia Faith Rivera, RAC Program Manager, Eastern Arizona Counties Resource...

Creative Dramatics. Beginnings Workshop.

ERIC Educational Resources Information Center

Gabriel, Julia; Sidlovskaya, Olga; Stotter, Ruth; Haugen, Kirsten; Leithold, Naomi

2000-01-01

Presents five articles on using creative dramatics in early childhood education: (1) "Drama: A Rehearsal for Life" (Julia Gabriel); (2) "Fairy Tales Enhance Imagination and Creative Thinking" (Olga Sidlovskaya); (3) "Starting with a Story" (Ruth Stotter); (4) "Using Creative Dramatics to Include All…

77 FR 41348 - Louisiana: Final Authorization of State-Initiated Changes and Incorporation by Reference of State...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-13

... by August 13, 2012. ADDRESSES: Send written comments to Alima Patterson, Region 6, Regional... Federal Register. FOR FURTHER INFORMATION CONTACT: Alima Patterson or Julia Banks at (214) 665-8533 or...

Using the Generic Mapping Tools From Within the MATLAB, Octave and Julia Computing Environments

NASA Astrophysics Data System (ADS)

Luis, J. M. F.; Wessel, P.

2016-12-01

The Generic Mapping Tools (GMT) is a widely used software infrastructure tool set for analyzing and displaying geoscience data. Its power to analyze and process data and produce publication-quality graphics has made it one of several standard processing toolsets used by a large segment of the Earth and Ocean Sciences. GMT's strengths lie in superior publication-quality vector graphics, geodetic-quality map projections, robust data processing algorithms scalable to enormous data sets, and ability to run under all common operating systems. The GMT tool chest offers over 120 modules sharing a common set of command options, file structures, and documentation. GMT modules are command line tools that accept input and write output, and this design allows users to write scripts in which one module's output becomes another module's input, creating highly customized GMT workflows. With the release of GMT 5, these modules are high-level functions with a C API, potentially allowing users access to high-level GMT capabilities from any programmable environment. Many scientists who use GMT also use other computational tools, such as MATLAB® and its clone Octave. We have built a MATLAB/Octave interface on top of the GMT 5 C API. Thus, MATLAB or Octave now has full access to all GMT modules as well as fundamental input/output of GMT data objects via a MEX function. Internally, the GMT/MATLAB C API defines six high-level composite data objects that handle input and output of data via individual GMT modules. These are data tables, grids, text tables (text/data mixed records), color palette tables, raster images (1-4 color bands), and PostScript. The API is responsible for translating between the six GMT objects and the corresponding native MATLAB objects. References to data arrays are passed if transposing of matrices is not required. The GMT and MATLAB/Octave combination is extremely flexible, letting the user harvest the general numerical and graphical capabilities of both systems, and represents a giant step forward in interoperability between GMT and other software package. We will present examples of the symbiotic benefits of combining these platforms. Two other extensions are also in the works: a nearly finished Julia wrapper and an embryonic Python module. Publication supported by FCT- project UID/GEO/50019/2013 - Instituto D. Luiz

A Julia set model of field-directed morphogenesis: developmental biology and artificial life.

PubMed

Levin, M

1994-04-01

One paradigm used in understanding the control of morphogenetic events is the concept of positional information, where sub-organismic components (such as cells) act in response to positional cues. It is important to determine what kinds of spatiotemporal patterns may be obtained by such a method, and what the characteristics of such a morphogenetic process might be. This paper presents a computer model of morphogenesis based on gene activity driven by interpreting a positional information field. In this model, the interactions of mutually regulating developmental genes are viewed as a map from R2 to R2, and are modeled by the complex number algebra. Functions in complex variables are used to simulate genetic interactions resulting in position-dependent differentiation. This is shown to be equivalent to computing modified Julia sets, and is seen to be sufficient to produce a very rich set of morphologies which are similar in appearance and several important characteristics to those of real organisms. The properties of this model can be used to study the potential role of fields and positional information as guiding factors in morphogenesis, as the model facilitates the study of static images, time-series (movies) and experimental alterations of the developmental process. It is thus shown that gene interactions can be modeled as a multi-dimensional algebra, and that only two interacting genes are sufficient for (i) complex pattern formation, (ii) chaotic differentiation behavior, and (iii) production of sharp edges from a continuous positional information field. This model is meant to elucidate the properties of the process of positional information-guided biomorphogenesis, not to serve as a simulation of any particular organism's development. Good quantitative data are not currently available on the interplay of gene products in morphogenesis. Thus, no attempt is made to link the images produced with actual pictures of any particular real organism. A brief introduction to top-down models and positional information is followed by the formal definition of the model. Then, the implications of the resulting morphologies to biological development are discussed, in terms of static shapes, parametrization studies, time series (movies made from individual frames), and behavior of the model in light of experimental perturbations. All figures (in grayscale), formulas and parameter values needed to re-create the figures and movies are included.

76 FR 28210 - Eastern Arizona Counties Resource Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-16

... DEPARTMENT OF AGRICULTURE Forest Service Eastern Arizona Counties Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Eastern Arizona Counties will meet...: Julia Faith Rivera, RAC Program Manager, Eastern Arizona Counties Resource Advisory Committee, Apache...

Prostate Cancer Research Training Program

DTIC Science & Technology

2011-06-01

Michelle Gray Julia Greenfield Lubaroff, p. 4 Gladys Murage Brittany Stokes Stacy-Ann Wright Students Accepted for the 2009 Program Kaylene...Greenfield 2008 Henry U. Maryland graduate school Gladys Murage 2008 Domann U. Mass graduate school Brittany Stokes 2008 Griffith none at this time

Cybersecurity Update

DTIC Science & Technology

2014-01-23

was broken, the willow bent when it must and survived." Robert Jordan, The Fires of Heaven CERT I Software Engineering Institute I...transfer-of-wealth-in-history-7000000598/ 8.  Caralli, Richard A.; Allen, Julia H.; White , David W. CERT® Resilience Management Model: A Maturity

The John Milner Nutrition and Cancer Prevention Research Practicum | Division of Cancer Prevention

Cancer.gov

Attendee Testimonial Plenty of Food for Thought Served Up at the John Milner Nutrition and Cancer Prevention Research Practicum by Julia Tobacyk Media Folder: research_groupView the Testimonial (PDF, 790 KB) Date: March 12-16, 2018 |

Advanced materials for the 21st century: The 1999 Julia R. Weertman symposium

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chung, Y.W.; Dunand, D.C.; Liaw, P.K.

1999-07-01

This book is divided into the following sections: (1) Dislocations and Cavitation; (2) High-Temperature Deformation; (3) Physical Metallurgy; (4) Mechanical Metallurgy; and (5) Nanocrystalline Materials. Separate abstracts were prepared for most of the papers in this book.

Ecological consequences of hydropower development in Central America: Impacts of small dams and water diversion on neotropical stream fish assemblages

USGS Publications Warehouse

Anderson, Elizabeth P.; Freeman, Mary C.; Pringle, C.M.

2006-01-01

Small dams for hydropower have caused widespread alteration of Central American rivers, yet much of recent development has gone undocumented by scientists and conservationists. We examined the ecological effects of a small hydropower plant (Dona Julia Hydroelectric Center) on two low-order streams (the Puerto Viejo River and Quebradon stream) draining a mountainous area of Costa Rica. Operation of the Dona Julia plant has dewatered these streams, reducing discharge to ~ 10% of average annual flow. This study compared fish assemblage composition and aquatic habitat upstream and downstream of diversion dams on two streams and along a ~ 4 km dewatered reach of the Puerto Viejo River in an attempt to evaluate current instream flow recommendations for regulated Costa Rican streams. Our results indicated that fish assemblages directly upstream and downstream of the dam on the third order Puerto Viejo River were dissimilar, suggesting that the small dam (< 15 in high) hindered movement of fishes. Along the ~ 4 km dewatered reach of the Puerto Viejo River, species count increased with downstream distance from the dam. However, estimated species richness and overall fish abundance were not significantly correlated with downstream distance from the dam. Our results suggested that effects of stream dewatering may be most pronounced for a subset of species with more complex reproductive requirements, classified as equilibrium-type species based on their life-history. In the absence of changes to current operations, we expect that fish assemblages in the Puerto Viejo River will be increasingly dominated by opportunistic-type, colonizing fish species. Operations of many other small hydropower plants in Costa Rica and other parts of Central America mirror those of Doha Julia; the methods and results of this study may be applicable to some of those projects.

Predicting chaos for infinite dimensional dynamical systems: The Kuramoto-Sivashinsky equation, a case study

NASA Technical Reports Server (NTRS)

Smyrlis, Yiorgos S.; Papageorgiou, Demetrios T.

1991-01-01

The results of extensive computations are presented in order to accurately characterize transitions to chaos for the Kuramoto-Sivashinsky equation. In particular, the oscillatory dynamics in a window that supports a complete sequence of period doubling bifurcations preceding chaos is followed. As many as thirteen period doublings are followed and used to compute the Feigenbaum number for the cascade and so enable, for the first time, an accurate numerical evaluation of the theory of universal behavior of nonlinear systems, for an infinite dimensional dynamical system. Furthermore, the dynamics at the threshold of chaos exhibit a fractal behavior which is demonstrated and used to compute a universal scaling factor that enables the self-similar continuation of the solution into a chaotic regime.

Trace element partitioning during the retorting of Julia Creek oil shale

DOE Office of Scientific and Technical Information (OSTI.GOV)

Patterson, J.H.; Dale, L.S.; Chapman, J.f.

1987-05-01

A bulk sample of oil shale from the Julia Creek deposit in Queensland was retorted under Fischer assay conditions at temperatures ranging from 250 to 550 /sup 0/C. The distributions of the trace elements detected in the shale oil and retort water were determined at each temperature. Oil distillation commenced at 300 /sup 0/C and was essentially complete at 500 /sup 0/C. A number of trace elements were progressively mobilized with increasing retort temperature up to 450 /sup 0/C. The following trace elements partitioned mainly to the oil: vanadium, arsenic, selenium, iron, nickel, titanium, copper, cobalt, and aluminum. Elements thatmore » also partitioned to the retort waters included arsenic, selenium, chlorine, and bromine. Element mobilization is considered to be caused by the volatilization of organometallic compounds, sulfide minerals, and sodium halides present in the oil shale. The results have important implications for shale oil refining and for the disposal of retort waters. 22 references, 5 tables.« less

Julia Roberts, Precognition, America’s Stonehenge, (A.S.), Detecting Information From the Past, Mistaking It For “Spirit,” and Defusing Martyrdom Practices Among Religious Zealots.

NASA Astrophysics Data System (ADS)

Pawa Matagamon, Sagamo

2001-11-01

Julia Roberts claimed to have had a precognitive dream about an orangutan giving her a full-body embrace, in the special about orangutans by the PBS's NY channel 13. When such events do occur for anyone, my research suggests the equivalent of spatial diffraction pattern information about an event can propagate in a backward sense through time. A sufficiently energized transponder is needed, and an appropriately sensitive receiver. Equivalent information from the past is detectable at A.S. Individuals ``experiencing" reincarnation may actually have been impacted by naturally occurring EMF, upon which information-conveying signals from the past have been superimposed. Individuals ``possessed" by spirits could actually be detecting unsettling signals. Native American world-view holds blameless deranged individuals, stating that Tseka'bec or the Great Spirit, perhaps EMF, is at fault. Zealots' expectations of a glorious reincarnation could be defused if rage is an artifact of EMF experiences. Society should attempt such a persuasion.

Fabricated Childhoods: Uncanny Encounters with the More-than-Human

ERIC Educational Resources Information Center

Blaise, Mindy

2016-01-01

This article is based on uncanny encounters with Julia deVille's exhibit, "Phantasmagoria". Inspired by Deleuzian-informed research practices, the author experiments with provoking practices to defy dominant developmental notions of childhood. This article reworks a humanist ontology by bringing together the discursive, the material, the…

Sabor Latino: Bodegas of Aesthetic Ideas

ERIC Educational Resources Information Center

Fattal, Laura Felleman

2006-01-01

Artifacts, notes Julia Marshall (2002) represent direct entryways into cultural inquiry and criticism for they are often ordinary, familiar, multiple, and integrated into everyday life. Associations of food with family conversations, interactions and gatherings in homes and/or cafes are often activities and routines that build continuity and close…

Unteachable Moments and Pedagogical Relationships

ERIC Educational Resources Information Center

Wang, Hongyu

2016-01-01

This paper discusses how Julia Kristeva's theory can inform our understanding of unteachable moments. It proposes a pedagogical relationship that can contain breakdowns of meanings and work toward breakthroughs to new awareness, particularly related to social justice pedagogy in teacher education. First, one example from the author's own teaching…

16 Extraordinary American Women.

ERIC Educational Resources Information Center

Hahn, Emma

This student book presents short biographies of notable women from diverse economic, ethnic, racial, social, and geographic backgrounds. Women highlighted include: (1) Helen Keller; (2) Eleanor Roosevelt; (3) Georgia O'Keeffe; (4) Julia Morgan; (5) Wilma P. Mankiller; (6) Rachel Carson; (7) Dorothea Lange; (8) Rosalyn Sussman Yalow; (9) Ella…

Education and Immigrant Girls: Building Bridges between Cultures. WEEA Digest.

ERIC Educational Resources Information Center

Potter, Julia L., Ed.

This digest features three articles on equal education for immigrant girls. The first, "Building Bridges between Cultures" (Julia L. Potter), highlights discussions with experts in the field of immigrant education, examining culture, family, and school; expectations for education; overcoming cultural barriers in education; parent involvement; and…

Revisiting Intellectual Traditions: Derrick P. Alridge

ERIC Educational Resources Information Center

Smiles, Robin V.

2005-01-01

This article describes the accomplishments of Derrick P. Alridge, Professor, Social Foundations of Education, University of Georgia-Athens. His research centers on the history and the study of the social and educational ideas of African American intellectuals, educators and social activists such as Du Bois, Woodson, Anna Julia Cooper and Nannie…

Toward a More Comprehensive Model of Teacher Pay. Research Brief

ERIC Educational Resources Information Center

National Center on Performance Incentives, 2008

2008-01-01

In "Toward a More Comprehensive Model of Teacher Pay"--a paper presented at the February 2008 National Center on Performance Incentives research to policy conference--Julia Koppich examines recent policy initiatives implementing new approaches to teacher pay. Her discussion focuses on four current initiatives: ProComp in Denver, Toledo…

Grants: View from the Campus.

ERIC Educational Resources Information Center

Mohrman, Kathryn, Ed.

Each of 13 authors, all experienced in obtaining grants, examines a separate element of the grantsgetting process. The essays include: The Characteristics of an Effective Grants Officer (Julia B. Leverenz); The Grants Office (Morton Cooper); Working with the Academic Dean (Robert C. Nordvall); Working with the Development Office (Barbara A.…

[Atomic absorption in mercury determination by "Julia-2" analyzer and urine mercury level in children of Moscow suburbs].

PubMed

Pavlovskaia, N A; Vagina, E N; Stepanova, E V

2000-01-01

The authors report on atomic absorption method determining mercury in urine. Being sensitive, with lower determination threshold of 10 nmole/l and correctness of 95.5%, the method was tested on children living in two districts of Moscow suburb.

Bringing Color into the Living Room: Analyzing "TV Guide" Covers, 1953 to 1997

ERIC Educational Resources Information Center

Upright, Craig

2015-01-01

Many contemporary students are unfamiliar with the cultural history of television programming in the United States. References to iconic series that represented significant milestones in minority representations and discussions of racial issues--such as "I Spy," "Julia," "All in the Family," or even "The Cosby…

Pedagogies of Difference: Unknowing Immigrant Teachers as Subjects Forever in Process

ERIC Educational Resources Information Center

Arndt, Sonja

2015-01-01

Immersed in the bicultural, increasingly globalized, yet uniquely local, Aotearoa New Zealand early childhood landscape, immigrant teacher subjects are shaped in complicated, entangled ways. This paper attempts to open fresh spaces for re-thinking knowable teacher identities by drawing on Julia Kristeva's work on the foreigner and the…

Deposition and Accumulation of Emerging Contaminants in the Sediments of the Palos Verde Shelf, California

EPA Science Inventory

Deposition and Accumulation of Emerging Contaminants in the Sediments of the Palos Verde Shelf, California Mark G. Cantwell, David R. Katz, Julia Sullivan, Robert P. Eganhouse, Monique M. Perron, Robert M. Burgess The Palos Verdes shelf is located off the Southern California coa...

Intellectual Activism: The Praxis of Dr. Anna Julia Cooper as a Blueprint for Equity-Based Pedagogy

ERIC Educational Resources Information Center

Sulé, V. Thandi

2013-01-01

African Americans have historically championed education as a vehicle for community enrichment (Anderson "Education"; Cooper "Voice"; Giddings). Among African Americans, education has long served as a mechanism to facilitate societal transformation--the form of transformation that addresses social inequities. For many African…

77 FR 63417 - Senior Executive Service; Departmental Performance Review Board Members

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-16

..., Deputy Assistant Secretary for Human Resources and Chief Human Capital Officer Christopher J. Meade.... FOR FURTHER INFORMATION CONTACT: Julia J. Markham, Human Resources Specialist (Executive Resources... least three members. In the case of an appraisal of a career appointee, more than half the members shall...

75 FR 71443 - Renewal of Charter for the Secretary's Advisory Committee on Human Research Protections

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-23

... on Human Research Protections AGENCY: Department of Health and Human Services, Office of the... Research Protections (SACHRP). FOR FURTHER INFORMATION CONTACT: Jerry Menikoff, M.D., J.D., Director, Office for Human Research Protections or Julia Gorey, J.D., Executive Director, SACHRP; U.S. Department...

What's Happening in February?

ERIC Educational Resources Information Center

Weissman, Ron; And Others

Brief information is given on 12 February events celebrated by Puerto Ricans: Groundhog Day; Candlemas; St. Valentine's Day; Mardi Gras; Ash Wednesday; Black History; and the birthdays of Thomas Alva Edison, Abraham Lincoln, Susan B. Anthony, Julia de Burgos, Luis Munoz Marin, and George Washington. Designed as a teacher resource, the booklet…

Eventos de Febrero (February Events).

ERIC Educational Resources Information Center

Toro, Leonor; Pla, Myrna

Designed as a resource for teachers, the booklet contains brief information on eight events celebrated by Puerto Ricans in the month of February: La Candelaria; Abraham Lincoln; Black History; Valentine's Day; Julia de Burgos; Luis Munoz Marin; George Washington; and the Carnaval. Written in Spanish, the booklet discusses the orgin and ways of…

Lost in Translation? "Bildung" between Ideological Debate and Pragmatism: A Response to Julia Campos

ERIC Educational Resources Information Center

Roche, Jorg

2015-01-01

The term "Bildung" is notoriously difficult to translate. Though it is often translated as "education," this does not entirely convey its meaning nor entirely explain its use in a myriad compounds such as "Bildungssprache" (language of/for education), "Bildungsweg" (path to education),…

jInv: A Modular and Scalable Framework for Electromagnetic Inverse Problems

NASA Astrophysics Data System (ADS)

Belliveau, P. T.; Haber, E.

2016-12-01

Inversion is a key tool in the interpretation of geophysical electromagnetic (EM) data. Three-dimensional (3D) EM inversion is very computationally expensive and practical software for inverting large 3D EM surveys must be able to take advantage of high performance computing (HPC) resources. It has traditionally been difficult to achieve those goals in a high level dynamic programming environment that allows rapid development and testing of new algorithms, which is important in a research setting. With those goals in mind, we have developed jInv, a framework for PDE constrained parameter estimation problems. jInv provides optimization and regularization routines, a framework for user defined forward problems, and interfaces to several direct and iterative solvers for sparse linear systems. The forward modeling framework provides finite volume discretizations of differential operators on rectangular tensor product meshes and tetrahedral unstructured meshes that can be used to easily construct forward modeling and sensitivity routines for forward problems described by partial differential equations. jInv is written in the emerging programming language Julia. Julia is a dynamic language targeted at the computational science community with a focus on high performance and native support for parallel programming. We have developed frequency and time-domain EM forward modeling and sensitivity routines for jInv. We will illustrate its capabilities and performance with two synthetic time-domain EM inversion examples. First, in airborne surveys, which use many sources, we achieve distributed memory parallelism by decoupling the forward and inverse meshes and performing forward modeling for each source on small, locally refined meshes. Secondly, we invert grounded source time-domain data from a gradient array style induced polarization survey using a novel time-stepping technique that allows us to compute data from different time-steps in parallel. These examples both show that it is possible to invert large scale 3D time-domain EM datasets within a modular, extensible framework written in a high-level, easy to use programming language.

HOT Program: A Success Story of Community Support for Education.

ERIC Educational Resources Information Center

Chan, Tak Cheung; Martin, Karen

This paper describes the Helping Our Teachers (HOT) Program, a community volunteer program started in the fall of 2000 at Julia P. Bryant Elementary School in Statesboro, Georgia. The purpose of the program is to formally organize all parent volunteers to help teachers and staff with school-related activities previously shouldered by…

A Historical View of Women in Music Education Careers

ERIC Educational Resources Information Center

Howe, Sondra Wieland

2009-01-01

Women music educators in the USA have been active in public and private schools, churches, and community organizations. In the nineteenth century, Julia E. Crane founded the Crane Institute of Music, the first institution to train music supervisors; and women developed kindergarten programs throughout the US. In the "private sphere," women taught…

Our Visions of Possibility for Literacy

ERIC Educational Resources Information Center

O'Keefe, Tim; Reinier, Rise; Gallagher, Kevin; Morgan, Bruce; Lopez-Robertson, Julia; Santman, Donna; Wong-Kam, JoAnn; Hill, Sharon; Christensen, Linda

2006-01-01

Tim O'Keefe, Rise Reinier and Kevin Gallagher, Bruce Morgan, Julia Lopez-Robertson, Donna Santman, JoAnn Wong-Kam, Sharon Hill, and Linda Christensen provide short essays describing their personal visions of possibility about literacy and how they maintain that passion and vision. Across a range of contexts, they reflect on the ways in which their…

A Semblance of Sense: Kristeva's and Gertrude Stein's Analysis of Language.

ERIC Educational Resources Information Center

Tate, Alison

1995-01-01

Examines the limits of Julia Kristeva's approach to modernist language. The article argues that Kristeva draws on a structuralist model of language and the unconscious, utilizing a code and deviation framework, thereby restricting her ability to elucidate explicit effects of modernist dislocation of language. The article also probes the problems…

Idea Bank: Measurement by the Numbers

ERIC Educational Resources Information Center

Metz, Julia

2016-01-01

Most laboratory activities conducted by students involve measurement, and measurement can only be as precise as the instrument with which it is made. When Julia Metz began her teaching career, she assumed most of the 10th grade chemistry students would have previously used common measuring devices such as metric rulers, graduated cylinders,…

Children's Literature about Refugees: A Catalyst in the Classroom

ERIC Educational Resources Information Center

Hope, Julia

2017-01-01

"It could happen to anybody", observed one nine-year-old child when her teacher read a book in class about refugees. Fiction provides the perfect conduit for the experiences of refugees so that young refugee students feel their experiences are validated, and their peers come to understand their situation. In this book, Julia Hope…

"Celebrating the Other": Power and Resistance as Prelude to Benhabib's Deliberative Democracy

ERIC Educational Resources Information Center

Brooks, Julia G.

2007-01-01

Each semester, Julia G. Brooks writes "silence=agreement" on the board during a discussion of socialization in her Introductory Sociology classes, and invites students to discuss their initial responses to this statement. Inevitably, there are students who agree with the statement outright, claiming "If people have something to say…

A Haphazard Reading of McHugh and Barlow (2010)

ERIC Educational Resources Information Center

McHugh, R. Kathryn; Barlow, David H.

2010-01-01

Replies to comments on Do haphazard reviews provide sound directions for dissemination efforts? by Eileen Gambrill and Julia H. Littell on the current authors' article The dissemination and implementation of evidence-based psychological treatments: A review of current efforts by Kathryn R. McHugh and David H. Barlow. In their commentary, Gambrill…

3 CFR 8376 - Proclamation 8376 of May 8, 2009. Mother's Day, 2009

Code of Federal Regulations, 2010 CFR

2010-01-01

... tradition of recognizing mothers grew out of the imagination of a few bold women. Julia Ward Howe, composer... this tradition in honor of mothers, the special women whose love and lessons profoundly impact our... this job alone as a single parent. They may be biological mothers, adoptive mothers, or foster mothers...

Fast Geostatistical Inversion using Randomized Matrix Decompositions and Sketchings for Heterogeneous Aquifer Characterization

NASA Astrophysics Data System (ADS)

O'Malley, D.; Le, E. B.; Vesselinov, V. V.

2015-12-01

We present a fast, scalable, and highly-implementable stochastic inverse method for characterization of aquifer heterogeneity. The method utilizes recent advances in randomized matrix algebra and exploits the structure of the Quasi-Linear Geostatistical Approach (QLGA), without requiring a structured grid like Fast-Fourier Transform (FFT) methods. The QLGA framework is a more stable version of Gauss-Newton iterates for a large number of unknown model parameters, but provides unbiased estimates. The methods are matrix-free and do not require derivatives or adjoints, and are thus ideal for complex models and black-box implementation. We also incorporate randomized least-square solvers and data-reduction methods, which speed up computation and simulate missing data points. The new inverse methodology is coded in Julia and implemented in the MADS computational framework (http://mads.lanl.gov). Julia is an advanced high-level scientific programing language that allows for efficient memory management and utilization of high-performance computational resources. Inversion results based on series of synthetic problems with steady-state and transient calibration data are presented.

The relationship between total cholinesterase activity and mortality in four butterfly species

USGS Publications Warehouse

Bargar, Timothy A.

2012-01-01

The relationship between total cholinesterase activity (TChE) and mortality in four butterfly species (great southern white [Ascia monuste], common buckeye [Junonia coenia], painted lady [Vanessa cardui], and julia butterflies [Dryas julia]) was investigated. Acute contact toxicity studies were conducted to evaluate the response (median lethal dose [LD50] and TChE) of the four species following exposure to the organophosphate insecticide naled. The LD50 for these butterflies ranged from 2.3 to 7.6 μg/g. The average level of TChE inhibition associated with significant mortality ranged from 26 to 67%, depending on the species. The lower bounds of normal TChE activity (2 standard deviations less than the average TChE for reference butterflies) ranged from 8.4 to 12.3 μM/min/g. As a percentage of the average reference TChE activity for the respective species, the lower bounds were similar to the inhibition levels associated with significant mortality, indicating there was little difference between the dose resulting in significant TChE inhibition and that resulting in mortality.

The United Kingdom Children's Laureate: The Story so Far

ERIC Educational Resources Information Center

Tucker, Nicholas

2014-01-01

Britain's Children's Laureate Scheme has now been running for 14 years. This article asks Quentin Blake, Anne Fine, Michael Morpurgo, Jacqueline Wilson, Anthony Browne, Michael Rosen and Julia Donaldson for their views on their own experience of taking up this post. It concludes with a discussion of the recurring issues raised by these Laureates…

What Is Protest? Feminism, Psychoanalysis and Methods of Social Change

ERIC Educational Resources Information Center

Hansen, Marie

2016-01-01

Despite the fact that feminism has recognised psychoanalysis to be a theory with direct application to the understanding of sexism for over 50 years, the application of psychoanalytic thinking to feminist activism has yet to be significantly realised. Using the work of Julia Kristeva, sexism is described as a symptom of an intolerable situation…

78 FR 26867 - Quarterly Publication of Individuals, Who Have Chosen To Expatriate

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-08

... residents, as defined in section 877(e)(2), are treated as if they were citizens of the United States who... GERRING BANG HEESEUNG BARRAZA SANTIAGO E BARTEL-MOUFANG DIANA BATTIG RAINER KARL BAUMANN MARTIN PETER... SUSANNE BARBARA HATHAWAY JANET K HAUPTLI DIANE MARIE HAY KATHERINE MARIE HEBRON VERA HEIM JULIA HEIM MARC...

Walking towards the Past: Loss and Place in Jane Urquhart's "A Map of Glass"

ERIC Educational Resources Information Center

Moore, Susan K.

2008-01-01

In this article, the author examines the notions of "loss" and "place" in relation to the mourning of one's personal and historical pasts. In doing so, the author draws upon the psychoanalytical writings of Julia Kristeva in an analysis of Jane Urquhart's 2005 novel "A Map of Glass"--a story about emplacement,…

Natural Law, Santa Clara, and the Supreme Court.

ERIC Educational Resources Information Center

Rodgers, Raymond S.; Lujan, Phillip

The court case, "Santa Clara Pueblo, et al. v. Julia Martinez, et al.," is the subject of this paper. It gives the background of the case of a woman whose children were refused admittance to tribal rolls because of an ordinance prohibiting the enrollment of children whose father is not a tribal member. The paper gives the arguments of…

Developing Talent in Mathematics, Science and Technology: A Conference on Academic Talent (Durham, North Carolina, March 28-30, 1988).

ERIC Educational Resources Information Center

Dreyden, Julia I., Ed.; And Others

An introductory chapter, "Contemporary Issues in Gifted Education" by Julia Dreyden and Shelagh Gallagher, summarizes National Science Foundation policy concerning development of new science and mathematics curricula and the work of the Talent Identification Program. Major conference papers and responses are then presented: "Developing Academic…

Recolonising an Ethics of Life: Repositioning Indigeneity in Australian "Gap Talk"

ERIC Educational Resources Information Center

Harrison, Neil

2012-01-01

Soon after it came to power in 2008, the Australian Government adopted six key targets relating to life expectancy, infant mortality, education and employment in its policy "Closing the Gap on Indigenous disadvantage". As it became apparent in 2011 that these targets were not being met, the Prime Minister, Julia Gillard, in her annual…

Stan: A Probabilistic Programming Language for Bayesian Inference and Optimization

ERIC Educational Resources Information Center

Gelman, Andrew; Lee, Daniel; Guo, Jiqiang

2015-01-01

Stan is a free and open-source C++ program that performs Bayesian inference or optimization for arbitrary user-specified models and can be called from the command line, R, Python, Matlab, or Julia and has great promise for fitting large and complex statistical models in many areas of application. We discuss Stan from users' and developers'…

75 FR 37856 - Lazard Global Total Return and Income Fund, Inc., et al.; Notice of Application

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-30

... investment companies to make periodic distributions of long-term capital gains with respect to their... INFORMATION CONTACT: Emerson S. Davis, Senior Counsel, at (202) 551-6868, or Julia K. Gilmer, Branch Chief, at... unlawful for any registered investment company to make long-term capital gains distributions more than once...

Issues in Associate Degree Nursing. Bridge to Success. Education and Service: A Partnership for Associate Degree Nursing.

ERIC Educational Resources Information Center

Southern Regional Education Board, Atlanta, GA.

This publication is a compilation of highlights from papers presented at the Associate Degree Nursing (ADN) project's regional conferences during 1983-84. Papers address pertinent issues in ADN education and practice. "AD Education: Are the Parameters Real?" (Julia Perkins) examines the parameters of associate degree nursing education from a…

Perspectives in Foreign Language Teaching. Conference on the Teaching of Foreign Lanugages and Literatures (12th, Youngstown, Ohio, October 21-22, 1988).

ERIC Educational Resources Information Center

Youngstown State Univ., OH. Dept. of Foreign Languages and Literatures.

Selected conference papers address the following topics in the field of foreign language instruction: "The Use of Video as a Reading Tool in Spanish Intermediate Courses" (Julia Coll); "Oral Patterns and Written Composition" (Alan Farrell); "Using Reading to Promote Proficiency" (K. Eckhard Kuhn-Osius, Annette Kym);…

Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (84th, Washington, DC, August 5-8, 2001). Miscellaneous.

ERIC Educational Resources Information Center

Association for Education in Journalism and Mass Communication.

The Miscellaneous section of the proceedings contains the following papers: "Hype versus Substance in the Final Weeks of the Broadcast Television Networks' 2000 Presidential Election Campaign Coverage" (Julia R. Fox and James Angelini); "Commercial Quality Influence on Perceptions of Television News" (Stephen Perry, Dana…

Origins of etioporphyrins in sediments - Evidence from stable carbon isotopes

NASA Technical Reports Server (NTRS)

Boreham, Christopher J.; Fookes, Christopher J. R.; Popp, Brian N.; Hayes, J. M.

1989-01-01

In samples of the Julia Creek and Condor oil shales (Australia, Albian, and early Tertiary, respectively) etioporphyrin III is significantly depleted in C-13 (4 per mil) relative to porphyrins derived from chlorophylls. This isotopic difference suggests a large contribution from some independent source. The haem group found in cytochromes derived from microbial sources is the most likely candidate.

Agent Reasoning Transparency: The Influence of Information Level on Automation Induced Complacency

DTIC Science & Technology

2017-06-01

ARL-TR-8044 ● JUNE 2017 US Army Research Laboratory Agent Reasoning Transparency: The Influence of Information Level on...US Army Research Laboratory Agent Reasoning Transparency: The Influence of Information Level on Automation-Induced Complacency by Julia...collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources

75 FR 6694 - Lewis and Clark National Wildlife Refuge and Julia Butler Hansen Refuge for the Columbian White...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-10

... white-tailed deer also benefits a large variety of wintering birds; a small herd of Roosevelt elk; river... recommendation. Refuge staff would also work with partners to ensure dredge-spoil islands provide benefits for... a bicycle and hiking trail, opening Crims and Price Islands to waterfowl hunting, closing a small...

My Body Had a Mind of Its Own: On Teaching, the Illusion of Control, and the Terrifying Limits of Governmentality (Part 2)

ERIC Educational Resources Information Center

Koza, Julia Eklund

2010-01-01

In the final installment of her two-part essay, Julia Eklund Koza analyzes prevalent control and management discourse in education, specifically, music education. Arguing that dominant understandings are hierarchical, gendered, illusory, and integrally related to projects and practices largely unrelated to schooling, she invites teachers and…

Effects of Affective Education Through Developmental Guidance Services: A One-Year Study.

ERIC Educational Resources Information Center

Stilwell, William E.; Barclay, James R.

This is an evaluation of developmental guidance services' affective education program. Data was collected on children enrolled in Buerkle School and in a control school (Julia Shannon) in Stuttgart School District No. 22 (AR). Third- and fourth-grade level boys and girls who had been in the program for the full 1975-1976 year provided data for…

Microsoft PowerPoint - ANDA-Webinar-Nov-2016-v4-CN yic. ...

Center for Drug Evaluation (CDER)

... Julia Lee 药学博士 美国食品药品管理局（ FDA） ... 点击可看到相关信息 : ... 点击此链接进行评估和获得证书 了解 CDER 小型企业和行业协助处的其他资源 : ...

Health evaluation of Columbian white-tailed deer on Julia Butler Hansen Refuge for the Columbian white-tailed deer

USGS Publications Warehouse

Creekmore, Terry E.; Glaser, Linda C.

1999-01-01

The objectives of this study were to: (1) gather baseline physiologic data on a subset of the population, (2) evaluate the data to determine the health of the animals sampled, (3) if possible, identify causes of poor health and, ( 4) provide refuge personnel with information that will aid them in managing the population.

Choreographing Theory: An Analysis of Edouard Lock's "Amelia" (2002) Questioning the Limits of Feminist and Poststructuralist Perspectives

ERIC Educational Resources Information Center

Ireland, Ruby

2009-01-01

Edouard Lock's dance film "Amelia" (2002) is the focus of this essay. Second-wave feminist and poststructuralist perspectives inform the analysis of this piece of contemporary dance. Laura Mulvey's male gaze theory and Julia Kristeva's theory of the semiotic and symbolic realms of representation are explored and critiqued, whilst Jacques Derrida's…

How Photography as Field Notes Helps in Understanding the Building the Education Revolution

ERIC Educational Resources Information Center

Loughlin, Jill

2013-01-01

This paper is the outcome of research conducted between June 2010 and January 2011 as part of understanding the building the education revolution (BER) a major policy initiative of the Australian Federal Government which commenced when Julia Gillard, now PM, was the Federal Minister of Education. The BER policy initiative was part of an economic…

Combining people, processes, and technology.

PubMed

Fishman, Julia

2017-06-01

Julia Fishman, managing director and vice-President, Clinical Strategy, at TeleTracking Technologies, discusses the in-use benefits of patient, staff, and asset tracking and flow technologies, arguing that their effective deployment across an NHS under considerable pressure on many fronts can free up more time to care, bring considerable cost and wider efficiencies, and help to address the perennial issue of 'bed blocking'.

Randomized, Controlled Trial of CBT Training for PTSD Providers

DTIC Science & Technology

2013-10-01

Statistician and Co- Investigator), Michelle Pucillo, MPH (Project Manager ), Gayatri Ranganathan , MS (Statistician), Julia Coleman (Research Associate...Journal of Consulting and Clinical Psychology, 74, 898-907. Ruzek, J. I., Friedman, M. J., & Murray, S. (2005). Toward a knowledge management system...result in superior CBT skills than wait-list control. Secondary Aim #1: To compare improvements in knowledge and attitudes following internet- based

Experiences of exclusion when living on a ventilator: reflections based on the application of Julia Kristeva's philosophy to caring science.

PubMed

Lindahl, Berit

2011-01-01

The research presented in this work represents reflections in the light of Julia Kristeva's philosophy concerning empirical data drawn from research describing the everyday life of people dependent on ventilators. It also presents a qualitative and narrative methodological approach from a person-centred perspective. Most research on home ventilator treatment is biomedical. There are a few published studies describing the situation of people living at home on a ventilator but no previous publications have used the thoughts in Kristeva's philosophy applied to this topic from a caring science perspective. The paper also addresses what a life at home on a ventilator may be like and will hopefully add some new aspects to the discussion of philosophical issues in nursing and the very essence of care. Kristeva's philosophy embraces phenomena such as language, abjection, body, and love, allowing her writings to make a fruitful contribution to nursing philosophy in that they strengthen, expand, and deepen a caring perspective. Moreover, her writings about revolt having the power to create hope add an interesting aspect to the work of earlier philosophers and nursing theorists. © 2010 Blackwell Publishing Ltd.

U.S. backs "well-being" programs for women. An interview with Julia Taft, Assistant Secretary of State for Population, Refugees and Migration.

PubMed

Scherr, E F

1998-09-01

This interview with Julia Taft, Assistant Secretary of State for Population, Refugees and Migration concerns a wide range of well-being programs for women in the US. The ICPD Program of Action considers family planning and reproductive health in the broader contexts of women's empowerment, girls¿ and boys' education, child health, and social elements (among them economic and environmental elements), that affect the lives of girls and women. US programs and policies encompass the promotion of the whole range of well-being of women and girls, of which family planning and reproductive health are key elements. Congress has passed a law ensuring complete access to reproductive health care services by making it a crime to use force or to interfere with reproductive health providers or their patients. There was also a recent decision to require federal employees' health insurance plans to cover contraceptives. The US supports several international organizations working on population issues such as UNFPA, UNICEF, UNAIDS, WHO, and UNDP. The UN will continually have to evaluate its progress so that in 15 years human rights, civil rights, and proper health care will have been extended to the entire world.

Beam-Riding Analysis of a Parabolic Laser-thermal Thruster

DOE Office of Scientific and Technical Information (OSTI.GOV)

Scharring, Stefan; Eckel, Hans-Albert; Roeser, Hans-Peter

2011-11-10

Flight experiments with laser-propelled vehicles (lightcrafts) are often performed by wire-guidance or with spin-stabilization. Nevertheless, the specific geometry of the lightcraft's optics and nozzle may provide for inherent beam-riding properties. These features are experimentally investigated in a hovering experiment at a small free flight test range with an electron-beam sustained pulsed CO{sub 2} high energy laser. Laser bursts are adapted with a real-time control to lightcraft mass and impulse coupling for ascent and hovering in a quasi equilibrium of forces. The flight dynamics is analyzed with respect to the impulse coupling field vs. attitude, given by the lightcraft's offset andmore » its inclination angle against the beam propagation axis, which are derived from the 3D-reconstruction of the flight trajectory from highspeed recordings. The limitations of the experimental parameters' reproducibility and its impact on flight stability are explored in terms of Julia sets. Solution statements for dynamic stabilization loops are presented and discussed.« less

Fast and Scalable Gaussian Process Modeling with Applications to Astronomical Time Series

NASA Astrophysics Data System (ADS)

Foreman-Mackey, Daniel; Agol, Eric; Ambikasaran, Sivaram; Angus, Ruth

2017-12-01

The growing field of large-scale time domain astronomy requires methods for probabilistic data analysis that are computationally tractable, even with large data sets. Gaussian processes (GPs) are a popular class of models used for this purpose, but since the computational cost scales, in general, as the cube of the number of data points, their application has been limited to small data sets. In this paper, we present a novel method for GPs modeling in one dimension where the computational requirements scale linearly with the size of the data set. We demonstrate the method by applying it to simulated and real astronomical time series data sets. These demonstrations are examples of probabilistic inference of stellar rotation periods, asteroseismic oscillation spectra, and transiting planet parameters. The method exploits structure in the problem when the covariance function is expressed as a mixture of complex exponentials, without requiring evenly spaced observations or uniform noise. This form of covariance arises naturally when the process is a mixture of stochastically driven damped harmonic oscillators—providing a physical motivation for and interpretation of this choice—but we also demonstrate that it can be a useful effective model in some other cases. We present a mathematical description of the method and compare it to existing scalable GP methods. The method is fast and interpretable, with a range of potential applications within astronomical data analysis and beyond. We provide well-tested and documented open-source implementations of this method in C++, Python, and Julia.

Quantitative Universality for a Class of Weakly Chaotic Systems

NASA Astrophysics Data System (ADS)

Venegeroles, Roberto

2014-02-01

We consider a general class of intermittent maps designed to be weakly chaotic, i.e., for which the separation of trajectories of nearby initial conditions is weaker than exponential. We show that all its spatio and temporal properties, hitherto regarded independently in the literature, can be represented by a single characteristic function ϕ. A universal criterion for the choice of ϕ is obtained within the Feigenbaum's renormalization-group approach. We find a general expression for the dispersion rate ζ( t) of initially nearby trajectories and we show that the instability scenario for weakly chaotic systems is more general than that originally proposed by Gaspard and Wang (Proc. Natl. Acad. Sci. USA 85:4591, 1988). We also consider a spatially extended version of such class of maps, which leads to anomalous diffusion, and we show that the mean squared displacement satisfies σ 2( t)˜ ζ( t). To illustrate our results, some examples are discussed in detail.

Various Attractors, Coexisting Attractors and Antimonotonicity in a Simple Fourth-Order Memristive Twin-T Oscillator

NASA Astrophysics Data System (ADS)

Zhou, Ling; Wang, Chunhua; Zhang, Xin; Yao, Wei

By replacing the resistor in a Twin-T network with a generalized flux-controlled memristor, this paper proposes a simple fourth-order memristive Twin-T oscillator. Rich dynamical behaviors can be observed in the dynamical system. The most striking feature is that this system has various periodic orbits and various chaotic attractors generated by adjusting parameter b. At the same time, coexisting attractors and antimonotonicity are also detected (especially, two full Feigenbaum remerging trees in series are observed in such autonomous chaotic systems). Their dynamical features are analyzed by phase portraits, Lyapunov exponents, bifurcation diagrams and basin of attraction. Moreover, hardware experiments on a breadboard are carried out. Experimental measurements are in accordance with the simulation results. Finally, a multi-channel random bit generator is designed for encryption applications. Numerical results illustrate the usefulness of the random bit generator.

Gender, British Administration and Mission Management of Education in Zambia 1900-1939

ERIC Educational Resources Information Center

Allen, Julia

2010-01-01

This article discusses the impact of including gender in the analytical framework in a study of the management and provision of education in Zambia from 1900 to 1939. It shows that a focus on gender allows females to enter the historical narrative and the leadership of women such as Mabel Shaw, Hannah Frances Davidson and Julia Smith can be given…

Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (78th, Washington, DC, August 9-12, 1995). Mass Communication and Society Division.

ERIC Educational Resources Information Center

Association for Education in Journalism and Mass Communication.

The mass communication and society section of the Proceedings contains the following 20 papers: "Media, Bureaucracy and the Success of Social Protest: Media Coverage of Environmental Movement Groups" (Julia B. Corbett); "How People Use Newspaper-Sponsored Community Bulletin Boards: A Field Test of 'The Evansville Courier's' Courier…

Countering the Master Narrative: The Development of the Alternative Black Curriculum in Social Studies, 1890-1940

ERIC Educational Resources Information Center

Murray, Alana D

2012-01-01

The purpose of this dissertation is to explore the development of the alternative black curriculum in social studies from 1890-1940. W.E.B. Du Bois and Carter G. Woodson worked in collaboration with women educators Nannie H. Burroughs and Anna Julia Cooper to create an alternative black curriculum that would support the intellectual growth of…

Geographic Differentiation of Francisella Tularensis using Molecular Methods

DTIC Science & Technology

2006-05-01

most often through direct exposure to infected animals or by bites from infected arthropod vectors. Recently, terrestrial and aquatic life cycles have...virulent in humans. F. tularensis species have been isolated throughout the Northern Hemisphere, but subsp. tularensis isolates appear restricted to North...John Wise for administering Pathogene-server access. From Northern Airzona University, I am grateful to Dr. Paul Keim, Miles Stanley, Julia Rhodes, Dr

Venezuela’s Corruption On the Rise: Fourteen Years of Chavismo

DTIC Science & Technology

2016-09-01

the Pérez administration, including increases in food and oil prices and decline in social programs.19 According to Julia Buxton, the austerity...level, and systematic corruption at the “interaction of the state and private actors in a contaminated social system.”45...corruption penetrating several aspects of Venezuelan society from food programs, healthcare, and the bureaucracies that control those basic goods

Corporeal and Sonic Diagrams for Cinematic Ethics in Rolf De Heer's "Dance Me to My Song"

ERIC Educational Resources Information Center

Hickey-Moody, Anna

2010-01-01

Rolf De Heer's 1997 Australian feature film "Dance Me to My Song" was devised with the late Heather Rose, a person with Cerebral Palsy. The film also features a central performance by Heather (as the character of Julia) and is clearly about "her world". The ethic of engagement exemplified by this film resonates with what Gerard Goggin has termed…

TTVFaster: First order eccentricity transit timing variations (TTVs)

NASA Astrophysics Data System (ADS)

Agol, Eric; Deck, Katherine

2016-04-01

TTVFaster implements analytic formulae for transit time variations (TTVs) that are accurate to first order in the planet-star mass ratios and in the orbital eccentricities; the implementations are available in several languages, including IDL, Julia, Python and C. These formulae compare well with more computationally expensive N-body integrations in the low-eccentricity, low mass-ratio regime when applied to simulated and to actual multi-transiting Kepler planet systems.

Maximizing Anthropometric Accommodation and Protection

DTIC Science & Technology

2007-08-01

here. This includes: 1) Greg Zehner, Scott Fleming, Cate Harrison, Julia Parakkat, Joseph Pellettiere, John Plaga , and Huaining Cheng from the...masks, etc. have complained that they have to create a separate size just to fit the manikins because the manikin heads are not human enough. Plaga et...Annual Meeting of the Aerospace Medical Association, May 2006, Orlando FL. Aviation, Space, and Environmental Medicine, Mar 2006; 77(3):215-353. Plaga

Fabric Structures Team Technology Update

DTIC Science & Technology

2011-11-01

Command Posts – • Julia McAdams – Chemical Engineer • Liz Swisher – Electrical Engineer • Chris Aall – Mechanical Engineer • Clinton McAdams...TEMPER design originally built for AMED through Force Provider (640 sq ft with a 20 ft long airlock) • The entire airlock is made of textiles and...Activity (USAMMDA) UNCLASSIFIED Large Command Post Airbeam Shelter NSRDEC Deployment – Sept 2011 UNCLASSIFIED Airbeam & Frame Backpackable Tents • Primary

Asteroid Lightcurve Analysis at the Oakley Observatory - October-November 2006

NASA Astrophysics Data System (ADS)

Ditteon, Richard; Hawkins, Scot

2007-09-01

Lightcurves for 23 asteroids were obtained at the Oakley Observatory over six nights in November of 2006: 24 Themis, 26 Proserpina, 57 Mnemosyne, 66 Maja, 67 Asia, 89 Julia, 143 Adria, 159 Aemilia, 179 Klytaemnestra, 227 Philosophia, 242 Kriemhild, 298 Baptistina, 340 Eduarda, 381 Myrrha, 536 Merapi, 563 Suleika, 665 Sabine, 799 Gudula, 1046 Edwin, 1087 Arabis, 1321 Majuba, 1621 Druzhba, 2152 Hannibal, and 5142 Okutama.

Syntheses of the hexahydroindene cores of indanomycin and stawamycin by combinations of iridium-catalyzed asymmetric allylic alkylations and intramolecular Diels-Alder reactions.

PubMed

Gärtner, Martin; Satyanarayana, Gedu; Förster, Sebastian; Helmchen, Günter

2013-01-02

Short and concise syntheses of the hexahydroindene cores of the antibiotics indanomycin (X-14547 A) and stawamycin are presented. Key methods used are an asymmetric iridium-catalyzed allylic alkylation, a modified Julia olefination, a Suzuki-Miyaura coupling, and an intramolecular Diels-Alder reaction. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

The Great Self-Advocacy Wave! Mom Teaches Most Important Lesson: "Explain!"

ERIC Educational Resources Information Center

Resciniti, Joey Lynn

2013-01-01

Joey Lynn Resciniti's first lesson on childhood hearing loss was a speech banana printed on glossy paper with bright red X's and O's. Her daughter, Julia, was almost 3 years old. The speech banana showed that she had not been hearing most of the conversation in the house. She had not heard the birds singing outside or the whoosh of…

Measuring What Matters Workshop Report

DTIC Science & Technology

2015-01-14

Measuring What Matters Workshop Report Katie Stewart Julia Allen Michelle Valdez Lisa Young January 2015 TECHNICAL NOTE CMU/SEI-2015-TN...the approach using a simple objective: teaching a child to properly brush his/her teeth. Next, we demonstrate the approach using a cybersecurity...Ensure you child’s teeth are healthy. G1: Ensure your child has everything needed to brush his/her teeth. G2: Ensure your child is brushing his

Measuring What Matters Workshop Report

DTIC Science & Technology

2015-01-01

Measuring What Matters Workshop Report Katie Stewart Julia Allen Michelle Valdez Lisa Young January 2015 TECHNICAL NOTE CMU/SEI-2015-TN...the approach using a simple objective: teaching a child to properly brush his/her teeth. Next, we demonstrate the approach using a cybersecurity...Ensure you child’s teeth are healthy. G1: Ensure your child has everything needed to brush his/her teeth. G2: Ensure your child is brushing his

JTF CapMed Warrior Transition Division

DTIC Science & Technology

2011-01-25

The Quadruple Aim: Working Together, Achieving Success 2011 Military Health System Conference JTF CapMed Warrior Transition Division 25 January 2011...Colonel Julia Adams 1 Military Health System Conference Joint Task Force National Capital Region Medical (JTF CapMed ) Report Documentation Page Form...DATES COVERED 00-00-2011 to 00-00-2011 4. TITLE AND SUBTITLE JTF CapMed Warrior Transition Division 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c

Proceedings of the Defense Nuclear Agency Conference on Arms Control and Verification Technology ACT Held in Williamsburg, Virginia on 1-4 June 1992

DTIC Science & Technology

1992-12-01

99352 Newington, VA 22122-9998 Steve Kigu Rick King Julia L. Klam NRL USAF IDA 45 Overlook Ave SW MS-4616 21A Eagan Ave. 1801 N. Beauregard St...ATTN: GARY RIPPLE ATTN: B STUPSKI JR ATTN: YANCEY PHILLIPS ATTN: C DIMAGGIO ATTN: C RUSSELL 21ST CENTURY INDUSTRIES ATTN: D BRANDWEIN ATTN: LEONARD M

Archaeological Investigations at Site 45-DO-326, Chief Joseph Dam Project, Washington.

DTIC Science & Technology

1984-01-01

Neal Crozier, Sarah K. Campbell and Julia E. Hammett wrote Chapter 2. Stephanie Livingston analyzed .- the faunal assemblage and wrote Chapter 4. Dorothy...mathematical equations derived from analysis of cases with known memberships. First, we assembled representative specimens for each -~~ ~ ,%, -. 79 Table 3-25...we used derived equations called discriminant functions to assign specimens In our collection lo the statistically defined projectile point types

Case Method Instruction: 25 Minutes of Discussion Can Make a Difference

DTIC Science & Technology

2007-07-01

discussion was facilitated by computer rather than an instructor. In a comparison of pretest and posttest scores, students performed better on a...that the research design utilized a within-subjects design without a control group. Thus, the pretest might have primed students to focus on the... Research Institute Jason M. Brunner and Christopher L. Vowels Kansas State University Consortium Research Fellows Program Julia M. Kim

Towards a Fiscally Constrained Pacific Posture

DTIC Science & Technology

2012-03-21

joint press conference with Australian Prime Minister Julia Gillard , President Obama emphasized U.S. intent in the Asia Pacific region when he... gillard -australia-joint-press (accessed February 5, 2012). 5 Laura MacInnis and Caren Bohan, “Obama seeks to hitch U.S. economy to Asian growth,” Reuters...November 16, 2011. http://www.whitehouse.gov/the-press-office/2011/11/16/remarks-president-obama-and-prime- minister- gillard -australia-joint-press

Cosmic history and a candidate parent asteroid for the quasicrystal-bearing meteorite Khatyrka

NASA Astrophysics Data System (ADS)

Meier, Matthias M. M.; Bindi, Luca; Heck, Philipp R.; Neander, April I.; Spring, Nicole H.; Riebe, My E. I.; Maden, Colin; Baur, Heinrich; Steinhardt, Paul J.; Wieler, Rainer; Busemann, Henner

2018-05-01

The unique CV-type meteorite Khatyrka is the only natural sample in which "quasicrystals" and associated crystalline Cu, Al-alloys, including khatyrkite and cupalite, have been found. They are suspected to have formed in the early Solar System. To better understand the origin of these exotic phases, and the relationship of Khatyrka to other CV chondrites, we have measured He and Ne in six individual, ∼40-μm-sized olivine grains from Khatyrka. We find a cosmic-ray exposure age of about 2-4 Ma (if the meteoroid was <3 m in diameter, more if it was larger). The U, Th-He ages of the olivine grains suggest that Khatyrka experienced a relatively recent (<600 Ma) shock event, which created pressure and temperature conditions sufficient to form both the quasicrystals and the high-pressure phases found in the meteorite. We propose that the parent body of Khatyrka is the large K-type asteroid 89 Julia, based on its peculiar, but matching reflectance spectrum, evidence for an impact/shock event within the last few 100 Ma (which formed the Julia family), and its location close to strong orbital resonances, so that the Khatyrka meteoroid could plausibly have reached Earth within its rather short cosmic-ray exposure age.

Todo Alumno: Un Manual de Recursos de PEER sobre Educacion Basada en Normas y Alumnos con Discapacidades (Every Single Student: A PEER Resource Manual on Standards-Based Education and Students with Disabilities).

ERIC Educational Resources Information Center

Landau, Julia K., Ed.; Romano, Carolyn A., Ed.; Vohs, Janet R., Ed.

This manual in Spanish covers thirteen different topics relevant to the education of students with disabilities in the era of educational reform and standards-based education. Sections include: (1) "Raising Standards of Learning: Standards-Based Education and Students with Disabilities" (Janet R. Vohs, Julia K. Landau, and Carolyn…

Enhancement of the United States Naval Academy (USNA) Polar Science Program (PSP)

DTIC Science & Technology

2013-09-30

buoy hull design was designed, modeled , and tested. And initial analysis was performed on the NAICEX snow and ice data by midshipmen. RESULTS...to help better understand how the IABP buoys are performing (Fig. 4). The near real time webcam information has proved extremely beneficial for... IABP ). Mishipman Julia Zook works with University of Washington Engineer Jim Johnson on the IK3T during her summer internship to Barrow, AK

Rapid Genome Analyses of Emergent Human Adenovirus 14a Causing 2006-7 Febrile Respiratory Illness (FRI) Outbreaks in the US via High Throughput Next-Generation Pyrosequencing Technique

DTIC Science & Technology

2008-12-01

David Metzgar2), Kevin L. Russell2), Adriana Kajon3), Kuei-Hsiang Lin4) and Julia A. Lynch1). Division of Viral Diseases, Walter Reed Army...Puc BP, Ronan MT, Roth GT, Sarkis GJ, Simons JF, Simpson JW, Srinivasan M, Tartaro KR, Tomasz A, Vogt KA , Volkmer GA, Wang SH, Weiner MP, Yu P

Final Technical Report - DOE Grant No. DE-FG02-07ER46424

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stroud, David

We present a final report on the activities undertaken under DOE Grant No. DE-FG02-07ER46424, titled "Interaction effects in quasi one-dimensional electronic systems," originally under the direction of Prof. Julia Meyer. The report includes an overview of the grant and the personnel involved, a list of publications acknowledging the grant, and a summary of the results and conclusions drawn from research supported by the grant.

Earlybird in South Staffordshire: Reflections on an Innovative Model of Interagency Working to Deliver an Intervention for Families of Preschool Children with Autistic Spectrum Disorder

ERIC Educational Resources Information Center

Halpin, Julia; Pitt, Sally; Dodd, Emma

2011-01-01

In this article three education and health services professionals, Julia Halpin, Sally Pitt and Emma Dodd, describe and reflect upon the way in which a small group of professionals from health and education services worked in collaboration to meet the need to inform and empower parents of preschool children with a diagnosis of autistic spectrum…

Army Aviation Operations in the Pacific Theater

DTIC Science & Technology

2014-12-04

unveiled the day before in Darwin . Alongside the Australian Prime Minister, Julia Gillard, President Barack Obama disclosed the details of a new defense...deployments) to Darwin starting in mid-2012.8 On 4 April 2012, the first contingent of approximately 200 Marines arrived in Darwin to signal the start of...and the start of rotational Marine deployments to Darwin , the American rebalancing to Asia-Pacific appeared to begin in earnest. Looking at a map

Review of Another Look of Valirie Lee, Julia Smith and Robert Croninger at High School Restructuring: More Evidence That It Improves Student Achievement and More Insight into Why

ERIC Educational Resources Information Center

Chen, Hsiao-ching; Chou, Chih-cheng

2007-01-01

High schools have over the past few decades been discredited with institutionalization, standardization, and academic-orientation (Manno, 1995; NASSP, 1996). As a result, it has failed to prepare students for the society which has been undergoing exponential change. A majority of students have been either neglected or left uncared for because of…

Pacific Century Institutions: Conceiving Options for United States Policy

DTIC Science & Technology

2012-03-21

November 2011 visit to Australia, just before the APEC Forum and Asia-Pacific summit. Citations: Barrack Obama and Julia Gillard , “Press Conference...www.whitehouse.gov/the-press-office/2011/11/16/remarks-president- obama-and-prime-minister- gillard -australia-joint-press, (accessed January 24, 2012). Barrack Obama...Base for Australia Irritates China,” New York Times, November 16, 2011, http://www.nytimes.com/2011/11/17/world/asia/obama-and- gillard -expand-us

The route to chaos for the Kuramoto-Sivashinsky equation

NASA Technical Reports Server (NTRS)

Papageorgiou, Demetrios T.; Smyrlis, Yiorgos

1990-01-01

The results of extensive numerical experiments of the spatially periodic initial value problem for the Kuramoto-Sivashinsky equation. This paper is concerned with the asymptotic nonlinear dynamics at the dissipation parameter decreases and spatio-temporal chaos sets in. To this end the initial condition is taken to be the same for all numerical experiments (a single sine wave is used) and the large time evolution of the system is followed numerically. Numerous computations were performed to establish the existence of windows, in parameter space, in which the solution has the following characteristics as the viscosity is decreased: a steady fully modal attractor to a steady bimodal attractor to another steady fully modal attractor to a steady trimodal attractor to a periodic attractor, to another steady fully modal attractor, to another periodic attractor, to a steady tetramodal attractor, to another periodic attractor having a full sequence of period-doublings (in parameter space) to chaos. Numerous solutions are presented which provide conclusive evidence of the period-doubling cascades which precede chaos for this infinite-dimensional dynamical system. These results permit a computation of the length of subwindows which in turn provide an estimate for their successive ratios as the cascade develops. A calculation based on the numerical results is also presented to show that the period doubling sequences found here for the Kuramoto-Sivashinsky equation, are in complete agreement with Feigenbaum's universal constant of 4,669201609... . Some preliminary work shows several other windows following the first chaotic one including periodic, chaotic, and a steady octamodal window; however, the windows shrink significantly in size to enable concrete quantitative conclusions to be made.

Oscillatory Critical Amplitudes in Hierarchical Models and the Harris Function of Branching Processes

NASA Astrophysics Data System (ADS)

Costin, Ovidiu; Giacomin, Giambattista

2013-02-01

Oscillatory critical amplitudes have been repeatedly observed in hierarchical models and, in the cases that have been taken into consideration, these oscillations are so small to be hardly detectable. Hierarchical models are tightly related to iteration of maps and, in fact, very similar phenomena have been repeatedly reported in many fields of mathematics, like combinatorial evaluations and discrete branching processes. It is precisely in the context of branching processes with bounded off-spring that T. Harris, in 1948, first set forth the possibility that the logarithm of the moment generating function of the rescaled population size, in the super-critical regime, does not grow near infinity as a power, but it has an oscillatory prefactor (the Harris function). These oscillations have been observed numerically only much later and, while the origin is clearly tied to the discrete character of the iteration, the amplitude size is not so well understood. The purpose of this note is to reconsider the issue for hierarchical models and in what is arguably the most elementary setting—the pinning model—that actually just boils down to iteration of polynomial maps (and, notably, quadratic maps). In this note we show that the oscillatory critical amplitude for pinning models and the Harris function coincide. Moreover we make explicit the link between these oscillatory functions and the geometry of the Julia set of the map, making thus rigorous and quantitative some ideas set forth in Derrida et al. (Commun. Math. Phys. 94:115-132, 1984).

α-Fluorovinyl Weinreb Amides and α- Fluoroenones from a Common Fluorinated Building Block

PubMed Central

Ghosh, Arun K.; Banerjee, Shaibal; Sinha, Saikat; Kang, Soon Bang; Zajc, Barbara

2009-01-01

Synthesis and reactivity of N-methoxy-N-methyl-(1,3-benzothiazol-2-ylsulfonyl)fluoroacetamide, a building block for Julia olefination, is reported. This reagent undergoes condensation reactions with aldehydes and cyclic ketones, to give α-fluorovinyl Weinreb amides. Olefination reactions proceed under mild, DBU-mediated conditions, or in the presence of NaH. DBU-mediated condensations proceed with either E or Z-selectivity, depending upon reaction conditions, whereas NaH-mediated reactions are ≥98% Z-stereoselective. Conversion of the Weinreb amide moiety in N-methoxy-N-methyl-(1,3-benzothiazol-2-ylsulfanyl)fluoroacetamide to ketones, followed by oxidation, resulted in another set of olefination reagents, namely (1,3-benzothiazol-2-ylsulfonyl)fluoromethyl phenyl and propyl ketones. In the presence of DBU, these compounds react with aldehydes tested to give α-fluoroenones with high Z-selectivity. The use of N-methoxy-N-methyl-(1,3-benzothiazol-2-ylsulfanyl)fluoroacetamide as a common fluorinated intermediate in the synthesis of α-fluorovinyl Weinreb amides and α-fluoroenones has been demonstrated. Application of the Weinreb amide to α-fluoro allyl amine synthesis is also shown. PMID:19361189

Dynamics of a new family of iterative processes for quadratic polynomials

NASA Astrophysics Data System (ADS)

Gutiérrez, J. M.; Hernández, M. A.; Romero, N.

2010-03-01

In this work we show the presence of the well-known Catalan numbers in the study of the convergence and the dynamical behavior of a family of iterative methods for solving nonlinear equations. In fact, we introduce a family of methods, depending on a parameter . These methods reach the order of convergence m+2 when they are applied to quadratic polynomials with different roots. Newton's and Chebyshev's methods appear as particular choices of the family appear for m=0 and m=1, respectively. We make both analytical and graphical studies of these methods, which give rise to rational functions defined in the extended complex plane. Firstly, we prove that the coefficients of the aforementioned family of iterative processes can be written in terms of the Catalan numbers. Secondly, we make an incursion into its dynamical behavior. In fact, we show that the rational maps related to these methods can be written in terms of the entries of the Catalan triangle. Next we analyze its general convergence, by including some computer plots showing the intricate structure of the Universal Julia sets associated with the methods.

Evaluation of Carbon Nanotube Thin Films for Optically Transparent Microwave Applications Using On-Wafer Probing of Corbino Disc Test Structures

DTIC Science & Technology

2013-03-01

the Material Under Test (MUT) against an open end of a coaxial cable . The novelty of our measurement scheme is the aspect of on-wafer probing. This...Directorate, ARL Julia B. Doggett George Washington University Henning Richter and Ramesh Sivarajan Nano -C, Inc...and Engineering Apprenticeship Program, George Washington University/Department of Defense, Washington, D.C., 20052 † Nano -C, Inc., 33 Southwest Park

Reading: Interaction With Memory

DTIC Science & Technology

1993-12-15

Ken Baime to Gregory Ward in conversation, August 8. 1990) 37. 1 used a gautter person before. but just to clean them. (Julia Hirschberg in...second of two items in a Ken Church was extremely generous with his ideas and his time in providing us with a large list of possible stimuli and their...target. For these pairs, we expected to replicate materials included words of the 48 triples from Balota and Loach McNamara and Altarriba’s finding of a

Comparison of Four Skin Decontamination Procedures Using Reactive Skin Decontamination Lotion (RSDL) Following Cutaneous VX Exposure in Guinea Pigs

DTIC Science & Technology

2016-01-01

DC) product following cutaneous exposure to VX was affected by the DC procedure. Fur-clipped, male, unanesthetized guinea pigs were used as subjects...RSDL) Following Cutaneous VX Exposure in Guinea Pigs Irwin Koplovitz Susan Schulz Julia Morgan Robert Reed Edward Clarkson C. Gary Hurst...Decontamination Procedures Using Reactive Skin 5a. CONTRACT NUMBER Decontamination Lotion (RSDL) Following Cutaneous VX Exposure in Guinea Pigs 5b

The footprints of Saharan Air Layer and lightning on the formation of tropical depressions over the eastern Atlantic Ocean

NASA Astrophysics Data System (ADS)

Centeno Delgado, Diana C.

In this study, the results of an observational analysis and a numerical analysis on the role of the Saharan Air Layer during tropical cyclogenesis (TC-genesis) are described. The observational analysis investigates the interaction of dust particles and lightning during the genesis stage of two developed cases (Hurricanes Helene 2006 and Julia 2010). The Weather Research and Forecasting (WRF) and WRF-Chemistry models were used to include and monitor the aerosols and chemical processes that affect TC-genesis. The numerical modeling involved two developed cases (Hurricanes Helene 2006 and Julia 2010) and two non-developed cases (Non-Developed 2011 and Non-Developed 2012). The Aerosol Optical Depth (AOD) and lightning analysis for Hurricane Helene 2006 demonstrated the time-lag connection through their positive contribution to TC-genesis. The observational analyses supported the fact that both systems developed under either strong or weak dust conditions. From the two cases, the location of strong versus weak dust outbreaks in association with lightning was essential interactions that impacted TC-genesis. Furthermore, including dust particles, chemical processes, and aerosol feedback in the simulations with WRF-CHEM provides results closer to observations than regular WRF. The model advantageously shows the location of the dust particles inside of the tropical system. Overall, the results from this study suggest that the SAL is not a determining factor that affects the formation of tropical cyclones.

Structure and Dynamics of Replication-Mutation Systems

NASA Astrophysics Data System (ADS)

Schuster, Peter

1987-03-01

The kinetic equations of polynucleotide replication can be brought into fairly simple form provided certain environmental conditions are fulfilled. Two flow reactors, the continuously stirred tank reactor (CSTR) and a special dialysis reactor are particularly suitable for the analysis of replication kinetics. An experimental setup to study the chemical reaction network of RNA synthesis was derived from the bacteriophage Qβ. It consists of a virus specific RNA polymerase, Qβ replicase, the activated ribonucleosides GTP, ATP, CTP and UTP as well as a template suitable for replication. The ordinary differential equations for replication and mutation under the conditions of the flow reactors were analysed by the qualitative methods of bifurcation theory as well as by numerical integration. The various kinetic equations are classified according to their dynamical properties: we distinguish "quasilinear systems" which have uniquely stable point attractors and "nonlinear systems" with inherent nonlinearities which lead to multiple steady states, Hopf bifuractions, Feigenbaum-like sequences and chaotic dynamics for certain parameter ranges. Some examples which are relevant in molecular evolution and population genetics are discussed in detail.

Computation of the anharmonic orbits in two piecewise monotonic maps with a single discontinuity

NASA Astrophysics Data System (ADS)

Li, Yurong; Du, Zhengdong

2017-02-01

In this paper, the bifurcation values for two typical piecewise monotonic maps with a single discontinuity are computed. The variation of the parameter of those maps leads to a sequence of border-collision and period-doubling bifurcations, generating a sequence of anharmonic orbits on the boundary of chaos. The border-collision and period-doubling bifurcation values are computed by the word-lifting technique and the Maple fsolve function or the Newton-Raphson method, respectively. The scaling factors which measure the convergent rates of the bifurcation values and the width of the stable periodic windows, respectively, are investigated. We found that these scaling factors depend on the parameters of the maps, implying that they are not universal. Moreover, if one side of the maps is linear, our numerical results suggest that those quantities converge increasingly. In particular, for the linear-quadratic case, they converge to one of the Feigenbaum constants δ _F= 4.66920160\\cdots.

Groundwater Remediation using Bayesian Information-Gap Decision Theory

NASA Astrophysics Data System (ADS)

O'Malley, D.; Vesselinov, V. V.

2016-12-01

Probabilistic analyses of groundwater remediation scenarios frequently fail because the probability of an adverse, unanticipated event occurring is often high. In general, models of flow and transport in contaminated aquifers are always simpler than reality. Further, when a probabilistic analysis is performed, probability distributions are usually chosen more for convenience than correctness. The Bayesian Information-Gap Decision Theory (BIGDT) was designed to mitigate the shortcomings of the models and probabilistic decision analyses by leveraging a non-probabilistic decision theory - information-gap decision theory. BIGDT considers possible models that have not been explicitly enumerated and does not require us to commit to a particular probability distribution for model and remediation-design parameters. Both the set of possible models and the set of possible probability distributions grow as the degree of uncertainty increases. The fundamental question that BIGDT asks is "How large can these sets be before a particular decision results in an undesirable outcome?". The decision that allows these sets to be the largest is considered to be the best option. In this way, BIGDT enables robust decision-support for groundwater remediation problems. Here we apply BIGDT to in a representative groundwater remediation scenario where different options for hydraulic containment and pump & treat are being considered. BIGDT requires many model runs and for complex models high-performance computing resources are needed. These analyses are carried out on synthetic problems, but are applicable to real-world problems such as LANL site contaminations. BIGDT is implemented in Julia (a high-level, high-performance dynamic programming language for technical computing) and is part of the MADS framework (http://mads.lanl.gov/ and https://github.com/madsjulia/Mads.jl).

Effects of a Commercial Drink on Acceleration Tolerance and Cognitive Performance

DTIC Science & Technology

2009-11-01

funded by a $120,000 grant from Coca - Cola Company, Atlanta GA. The authors wish to thank Mr. Mac Baker, Capt Julia McGregor, Mr. Tom Beltran, and Mr...recommendation or endorsement of the Coca Cola Company or the product tested. v Approved for public release; distribution unlimited; Approved by 311 th...drink (Full Throttle®, made by the Coca - Cola Company, at volumes equating to a caffeine dose of 5 mg caffeine per kg of body weight), an uncaffeinated

The Impact of an Intelligent Computer-Based Tutor on Classroom Social Processes: An Ethnographic Study.

DTIC Science & Technology

1993-02-11

of computer games such as Where in the World is Carmen Santiago ?, provided a milieu in which these boys could fantasize about their prowess and...Organization for Economic Pacific Bell Cooperation and Development 2600 Camino Ramon 2, rue Andru-Pascal Room 3S-450 75016 PARIS San Ramon, CA 94583 FRANCE...Psychology University of Delaware Dr. Arthur Melmed Newark, DE 19711 Computer Arts and Education Laboratory Ms. Julia S. Hough New York University 110 W

Language and Community in Orwell’s Anglo-India and in 1984.

DTIC Science & Technology

1986-05-01

which party women do not wear, the same scent the disgusts Winston when he smells it during intercourse with a proletarian whore (1984 56). But on Julia...cover. Give the name(s) of the author(s) in conventional order (for example, John R. Doe or, if author prefers , 1. Robert Doe). In addition, list the...classes smelled (The Road to Wigan Pier 128). Although he is the first to condemn his belief as simply a class prejudice taught him in his youth, the

2nd Annual Postdoc Research Day: US Army Research Laboratory PosterSymposia and Activities

DTIC Science & Technology

2018-04-12

ARL-SR-0394•APR 2018 US Army Research Laboratory 2nd Annual Postdoc Research Day: US Army Research Laboratory Poster Symposia and Activities by...Do not return it to the originator. ARL-SR-0394•APR 2018 US Army Research Laboratory 2nd Annual Postdoc Research Day: US Army Research Laboratory...Poster Symposia and Activities by Efraín Hernández–Rivera Weapons and Materials Research Directorate, ARL Julia Cline Oak Ridge Institute for Science and

A Global Transnational Sunni Caliphate: Realistic or Utopian Vision?

DTIC Science & Technology

2009-04-01

sovereignty and power, and are the completion of the Bible and Torah. The Quran is God’s divine word to man on how to conduct himself in this life in...conferences/WP886/ pdfs /WP886. pdf , (accessed on 3 April 2009). 16 Notes 49 Julia Voelker McQuaid reporting on Jakarata Caliphate conference observed...http://www.wiltonpark.org.uk/documents/conferences/WP886/ pdfs /WP886. pdf (accessed on 3 April 2009), p. 5. 50 Ibid, p. 20. 51 Ibid, p. 20. 17

Machine Learning Techniques in Optimal Design

NASA Technical Reports Server (NTRS)

Cerbone, Giuseppe

1992-01-01

Many important applications can be formalized as constrained optimization tasks. For example, we are studying the engineering domain of two-dimensional (2-D) structural design. In this task, the goal is to design a structure of minimum weight that bears a set of loads. A solution to a design problem in which there is a single load (L) and two stationary support points (S1 and S2) consists of four members, E1, E2, E3, and E4 that connect the load to the support points is discussed. In principle, optimal solutions to problems of this kind can be found by numerical optimization techniques. However, in practice [Vanderplaats, 1984] these methods are slow and they can produce different local solutions whose quality (ratio to the global optimum) varies with the choice of starting points. Hence, their applicability to real-world problems is severely restricted. To overcome these limitations, we propose to augment numerical optimization by first performing a symbolic compilation stage to produce: (a) objective functions that are faster to evaluate and that depend less on the choice of the starting point and (b) selection rules that associate problem instances to a set of recommended solutions. These goals are accomplished by successive specializations of the problem class and of the associated objective functions. In the end, this process reduces the problem to a collection of independent functions that are fast to evaluate, that can be differentiated symbolically, and that represent smaller regions of the overall search space. However, the specialization process can produce a large number of sub-problems. This is overcome by deriving inductively selection rules which associate problems to small sets of specialized independent sub-problems. Each set of candidate solutions is chosen to minimize a cost function which expresses the tradeoff between the quality of the solution that can be obtained from the sub-problem and the time it takes to produce it. The overall solution to the problem, is then obtained by solving in parallel each of the sub-problems in the set and computing the one with the minimum cost. In addition to speeding up the optimization process, our use of learning methods also relieves the expert from the burden of identifying rules that exactly pinpoint optimal candidate sub-problems. In real engineering tasks it is usually too costly to the engineers to derive such rules. Therefore, this paper also contributes to a further step towards the solution of the knowledge acquisition bottleneck [Feigenbaum, 1977] which has somewhat impaired the construction of rulebased expert systems.

A review of Education and Social Media using conflict and functionalist theories

NASA Astrophysics Data System (ADS)

Cian, Heidi; Amann, Holly

2017-09-01

Education and Social Media: Toward a Digital Future (2016), edited by Christine Greenhow, Julia Sonnevend, and Colin Agur, is a compilation of essays by leading contributors to the digital and social media movement in education. The chapters within this volume provide a granular look at the current landscape of how digital media is utilized across educational levels, fields of study, and geographic areas. The book is divided into three sections discussing the emerging use of social media in education, challenges in its implementation, and potential directions as tech-based education continues to evolve. In this review, we situate the ideas presented in Education and Social Media in the functionalist and conflict theories of educational perspective to further illuminate the potential of digital learning in supporting increased access to education for marginalized student populations. We discuss how these competing views are both given voice in Education and Social Media, prompting the reader to critically reflect on advantages and dangers presented by increased use of technological platforms in educational settings. Topics discussed include online universities, peer-developed curriculum, and differential use of technology based on school socioeconomic demographics. We also suggest areas that have emerged in need of further discussion since the book's publication.

Proceedings of a Symposium on the Physics and Technology of Amorphous SiO2 Held in Les Arcs, France on 29 June-3 July 1987

DTIC Science & Technology

1987-07-03

Chibaudo and Jean - Jacques Niez whilst the on-site smooth running was assured by Julia, Bob and Neil Devine and Bernadette Bonnefond - sincere thanks...SOL-GEL COATINGS FOR Nd : GLASS HIGH-POWER PULSED LASER USES Hervb Floch, Jean - Jacques Priotton, and Ian Malvil Thomas* Commissariat A ’Energie Atomique...PROPERTIES OF PLASMA ENHANCED CVD SILICON OXYNITRIDE FILMS Yves Cros, Jean Christophe Rostaing LEPES*, C.N.R.S. BP 166 38042 Grenoble Cedex, France

A revision of the tribe Planitorini van Achterberg (Hymenoptera, Braconidae, Euphorinae), with description of a new genus from Australia.

PubMed

van Achterberg, Cornelis; Quicke, Donald L J; Boring, C Andrew

2017-01-01

The tribe Planitorini van Achterberg (Hymenoptera: Braconidae: Euphorinae) is revised. One new genus Paramannokeraia gen. n. (type species: P. gibsoni sp. n. ) and five new species from Australia are described and illustrated: Mannokeraia albipalpis van Achterberg, sp. n. , M. nigrita van Achterberg, sp. n. , M. punctata van Achterberg, sp. n. , Paramannokeraia gibsoni van Achterberg & Quicke, sp. n. and P. juliae van Achterberg, sp. n. The tribe Mannokeraiini van Achterberg, 1995, is synonymized with the tribe Planitorini ( syn. n. ).

A revision of the tribe Planitorini van Achterberg (Hymenoptera, Braconidae, Euphorinae), with description of a new genus from Australia

PubMed Central

van Achterberg, Cornelis; Quicke, Donald L.J.; Boring, C. Andrew

2017-01-01

Abstract The tribe Planitorini van Achterberg (Hymenoptera: Braconidae: Euphorinae) is revised. One new genus Paramannokeraia gen. n. (type species: P. gibsoni sp. n.) and five new species from Australia are described and illustrated: Mannokeraia albipalpis van Achterberg, sp. n., M. nigrita van Achterberg, sp. n., M. punctata van Achterberg, sp. n., Paramannokeraia gibsoni van Achterberg & Quicke, sp. n. and P. juliae van Achterberg, sp. n. The tribe Mannokeraiini van Achterberg, 1995, is synonymized with the tribe Planitorini (syn. n.). PMID:29290713

Structured chaos in a devil's staircase of the Josephson junction.

PubMed

Shukrinov, Yu M; Botha, A E; Medvedeva, S Yu; Kolahchi, M R; Irie, A

2014-09-01

The phase dynamics of Josephson junctions (JJs) under external electromagnetic radiation is studied through numerical simulations. Current-voltage characteristics, Lyapunov exponents, and Poincaré sections are analyzed in detail. It is found that the subharmonic Shapiro steps at certain parameters are separated by structured chaotic windows. By performing a linear regression on the linear part of the data, a fractal dimension of D = 0.868 is obtained, with an uncertainty of ±0.012. The chaotic regions exhibit scaling similarity, and it is shown that the devil's staircase of the system can form a backbone that unifies and explains the highly correlated and structured chaotic behavior. These features suggest a system possessing multiple complete devil's staircases. The onset of chaos for subharmonic steps occurs through the Feigenbaum period doubling scenario. Universality in the sequence of periodic windows is also demonstrated. Finally, the influence of the radiation and JJ parameters on the structured chaos is investigated, and it is concluded that the structured chaos is a stable formation over a wide range of parameter values.

Structured chaos in a devil's staircase of the Josephson junction

NASA Astrophysics Data System (ADS)

Shukrinov, Yu. M.; Botha, A. E.; Medvedeva, S. Yu.; Kolahchi, M. R.; Irie, A.

2014-09-01

The phase dynamics of Josephson junctions (JJs) under external electromagnetic radiation is studied through numerical simulations. Current-voltage characteristics, Lyapunov exponents, and Poincaré sections are analyzed in detail. It is found that the subharmonic Shapiro steps at certain parameters are separated by structured chaotic windows. By performing a linear regression on the linear part of the data, a fractal dimension of D = 0.868 is obtained, with an uncertainty of ±0.012. The chaotic regions exhibit scaling similarity, and it is shown that the devil's staircase of the system can form a backbone that unifies and explains the highly correlated and structured chaotic behavior. These features suggest a system possessing multiple complete devil's staircases. The onset of chaos for subharmonic steps occurs through the Feigenbaum period doubling scenario. Universality in the sequence of periodic windows is also demonstrated. Finally, the influence of the radiation and JJ parameters on the structured chaos is investigated, and it is concluded that the structured chaos is a stable formation over a wide range of parameter values.

Structured chaos in a devil's staircase of the Josephson junction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shukrinov, Yu. M.; Botha, A. E., E-mail: bothaae@unisa.ac.za; Medvedeva, S. Yu.

2014-09-01

The phase dynamics of Josephson junctions (JJs) under external electromagnetic radiation is studied through numerical simulations. Current-voltage characteristics, Lyapunov exponents, and Poincaré sections are analyzed in detail. It is found that the subharmonic Shapiro steps at certain parameters are separated by structured chaotic windows. By performing a linear regression on the linear part of the data, a fractal dimension of D = 0.868 is obtained, with an uncertainty of ±0.012. The chaotic regions exhibit scaling similarity, and it is shown that the devil's staircase of the system can form a backbone that unifies and explains the highly correlated and structured chaotic behavior.more » These features suggest a system possessing multiple complete devil's staircases. The onset of chaos for subharmonic steps occurs through the Feigenbaum period doubling scenario. Universality in the sequence of periodic windows is also demonstrated. Finally, the influence of the radiation and JJ parameters on the structured chaos is investigated, and it is concluded that the structured chaos is a stable formation over a wide range of parameter values.« less

Advanced Computational Framework for Environmental Management ZEM, Version 1.x

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vesselinov, Velimir V.; O'Malley, Daniel; Pandey, Sachin

2016-11-04

Typically environmental management problems require analysis of large and complex data sets originating from concurrent data streams with different data collection frequencies and pedigree. These big data sets require on-the-fly integration into a series of models with different complexity for various types of model analyses where the data are applied as soft and hard model constraints. This is needed to provide fast iterative model analyses based on the latest available data to guide decision-making. Furthermore, the data and model are associated with uncertainties. The uncertainties are probabilistic (e.g. measurement errors) and non-probabilistic (unknowns, e.g. alternative conceptual models characterizing site conditions).more » To address all of these issues, we have developed an integrated framework for real-time data and model analyses for environmental decision-making called ZEM. The framework allows for seamless and on-the-fly integration of data and modeling results for robust and scientifically-defensible decision-making applying advanced decision analyses tools such as Bayesian- Information-Gap Decision Theory (BIG-DT). The framework also includes advanced methods for optimization that are capable of dealing with a large number of unknown model parameters, and surrogate (reduced order) modeling capabilities based on support vector regression techniques. The framework is coded in Julia, a state-of-the-art high-performance programing language (http://julialang.org). The ZEM framework is open-source and can be applied to any environmental management site. The framework will be open-source and released under GPL V3 license.« less

A resolution commemorating the lives and work of Jesuit Fathers Ignacio Ellacuria, Ignacio Martin-Baro, Segundo Montes, Amando Lopez, Juan Ramon Moreno, Joaquin Lopez y Lopez, and housekeeper Julia Elba Ramos and her daughter Celina Mariset Ramos on the occasion of the 20th anniversary of their deaths on November 16, 1989, at the Universidad Centroamericana Jose Simeon Canas located in San Salvador, El Salvador.

THOMAS, 111th Congress

Sen. Feingold, Russell D. [D-WI

2009-10-26

Senate - 10/26/2009 Submitted in the Senate, considered, and agreed to without amendment and with a preamble by Unanimous Consent. (All Actions) Tracker: This bill has the status Agreed to in SenateHere are the steps for Status of Legislation:

NASA Ames Hosts 2017 Breakthrough Prize

NASA Image and Video Library

2016-12-08

NASA's Ames Research Center in Silicon Valley was the location of the 5th annual Breakthrough Prize ceremony, honoring scientific achievement. Researchers and engineers rubbed shoulders with Hollywood actors, Top-40 musicians, astronauts, sports heroes and Silicon Valley luminaries on the red carpet. Winners were honored with $3 million dollar prizes in the categories of physics, life sciences and mathematics with more than $25 million dollars awarded during the ceremony. The prizes were created by Sergey Brin, co-founder of Google and Anne Wojcicki, founder of 23 and Me; Mark Zuckerberg and Priscilla Chan of Facebook, and Yuri and Julia Milner.

Neotropical species of Meteorus Haliday (Hymenoptera: Braconidae: Meteorinae) parasitizing Arctiinae (Lepidoptera: Noctuoidea: Erebidae).

PubMed

Aguirre, Helmuth; Shaw, Scott R

2014-03-17

Three new species of Meteorus parasitoids of Arctiinae are described: Meteorus anuae n. sp., M. juliae n. sp. and M. mirandae n. sp. The first biological record for M. cecavorum Aguirre & Shaw as well as its cocoon description is reported. A comprehensive key for the Neotropical Meteorus attacking Arctiinae is provided. A total of nine Meteorus species have been reared from Arctiinae in the Neotropical Region. Six of them are gregarious and three solitary. The biological information about host and food plants concurs with the hypothesis of specialist parasitoids preferring "nasty" caterpillars.

Ruptures of vulnerability: Linda Stein's Knight Series.

PubMed

Bible, Ann Vollmann

2010-01-01

Drawing on the work of Monique Wittig, this article understands Linda Stein's Knight Series as a lacunary writing communicating both her challenges to come to representation and her creative registration of subjectivity. The argument is grounded in an exploration of the rich interplay of power and vulnerability across the series as against the discourse of escapist fashion. Specifically, Stein's critical contradictions of inside and outside, conflated temporality, disjunctions between decoration and abstraction, and fluidity of sex and gender are examined. The discussion is elaborated through consideration of the work of Julia Kristeva, Elizabeth Grosz, and Hayao Miyazaki.

Field Trial of Attentuated Salmonella Typhi Live Oral Vaccine Ty21a in Liquid and Enteric-Coated Formulations and Epidemiological Survey for Incidence of Diarrhea due to Shigella Species

DTIC Science & Technology

1988-05-18

trial was initiated in Area Sur Oriente and Area Norte, Santiago, Chile,. to compare the relative and absolute’ efficacy of three doses of Ty2la vaccine ...neighboirhood of Area Oriente, Santiago with the broad objective of pr3paring a field area uhere the efficacy of vaccines against Shigella...The high incidence rates of Shisella, ETEC, and EPEC infection make Santa Julia a suitable place for testing the efficacy of vaccines against these

A review of Education and Social Media using functionalist and conflict theories of educational purposes

NASA Astrophysics Data System (ADS)

Cian, Heidi; Amann, Holly

2017-11-01

Education and Social Media: Toward a Digital Future (2016), edited by Christine Greenhow, Julia Sonnevend, and Colin Agur, is a compilation of essays by leading contributors to the digital and social media movement in education. The chapters within this volume provide a granular look at the current landscape of how digital media is utilized across educational levels, fields of study, and geographic areas. The book is divided into three sections discussing the emerging use of social media in education, challenges in its implementation, and potential directions as tech-based education continues to evolve. In this review, we situate the ideas presented in Education and Social Media in the functionalist and conflict theories of educational perspective to further illuminate the potential of digital learning in supporting increased access to education for marginalized student populations. We discuss how these competing views are both given voice in Education and Social Media, prompting the reader to critically reflect on advantages and dangers presented by increased use of technological platforms in educational settings. Topics discussed include online universities, peer-developed curriculum, and differential use of technology based on school socioeconomic demographics. We also suggest areas that have emerged in need of further discussion since the book's publication.

Closer look at time averages of the logistic map at the edge of chaos

NASA Astrophysics Data System (ADS)

Tirnakli, Ugur; Tsallis, Constantino; Beck, Christian

2009-05-01

The probability distribution of sums of iterates of the logistic map at the edge of chaos has been recently shown [U. Tirnakli , Phys. Rev. E 75, 040106(R) (2007)] to be numerically consistent with a q -Gaussian, the distribution which—under appropriate constraints—maximizes the nonadditive entropy Sq , which is the basis of nonextensive statistical mechanics. This analysis was based on a study of the tails of the distribution. We now check the entire distribution, in particular, its central part. This is important in view of a recent q generalization of the central limit theorem, which states that for certain classes of strongly correlated random variables the rescaled sum approaches a q -Gaussian limit distribution. We numerically investigate for the logistic map with a parameter in a small vicinity of the critical point under which conditions there is convergence to a q -Gaussian both in the central region and in the tail region and find a scaling law involving the Feigenbaum constant δ . Our results are consistent with a large number of already available analytical and numerical evidences that the edge of chaos is well described in terms of the entropy Sq and its associated concepts.

Studies in using a universal exchange and inference language for evidence based medicine. Semi-automated learning and reasoning for PICO methodology, systematic review, and environmental epidemiology.

PubMed

Robson, Barry

2016-12-01

The Q-UEL language of XML-like tags and the associated software applications are providing a valuable toolkit for Evidence Based Medicine (EBM). In this paper the already existing applications, data bases, and tags are brought together with new ones. The particular Q-UEL embodiment used here is the BioIngine. The main challenge is one of bringing together the methods of symbolic reasoning and calculative probabilistic inference that underlie EBM and medical decision making. Some space is taken to review this background. The unification is greatly facilitated by Q-UEL's roots in the notation and algebra of Dirac, and by extending Q-UEL into the Wolfram programming environment. Further, the overall problem of integration is also a relatively simple one because of the nature of Q-UEL as a language for interoperability in healthcare and biomedicine, while the notion of workflow is facilitated because of the EBM best practice known as PICO. What remains difficult is achieving a high degree of overall automation because of a well-known difficulty in capturing human expertise in computers: the Feigenbaum bottleneck. Copyright © 2016 Elsevier Ltd. All rights reserved.

Local and global approaches to the problem of Poincaré recurrences. Applications in nonlinear dynamics

NASA Astrophysics Data System (ADS)

Anishchenko, V. S.; Boev, Ya. I.; Semenova, N. I.; Strelkova, G. I.

2015-07-01

We review rigorous and numerical results on the statistics of Poincaré recurrences which are related to the modern development of the Poincaré recurrence problem. We analyze and describe the rigorous results which are achieved both in the classical (local) approach and in the recently developed global approach. These results are illustrated by numerical simulation data for simple chaotic and ergodic systems. It is shown that the basic theoretical laws can be applied to noisy systems if the probability measure is ergodic and stationary. Poincaré recurrences are studied numerically in nonautonomous systems. Statistical characteristics of recurrences are analyzed in the framework of the global approach for the cases of positive and zero topological entropy. We show that for the positive entropy, there is a relationship between the Afraimovich-Pesin dimension, Lyapunov exponents and the Kolmogorov-Sinai entropy either without and in the presence of external noise. The case of zero topological entropy is exemplified by numerical results for the Poincare recurrence statistics in the circle map. We show and prove that the dependence of minimal recurrence times on the return region size demonstrates universal properties for the golden and the silver ratio. The behavior of Poincaré recurrences is analyzed at the critical point of Feigenbaum attractor birth. We explore Poincaré recurrences for an ergodic set which is generated in the stroboscopic section of a nonautonomous oscillator and is similar to a circle shift. Based on the obtained results we show how the Poincaré recurrence statistics can be applied for solving a number of nonlinear dynamics issues. We propose and illustrate alternative methods for diagnosing effects of external and mutual synchronization of chaotic systems in the context of the local and global approaches. The properties of the recurrence time probability density can be used to detect the stochastic resonance phenomenon. We also discuss how the fractal dimension of chaotic attractors can be estimated using the Poincaré recurrence statistics.

Isolation and Characterization of a Toxic Moiety of Low Molecular Weight from Clostridium botulinum Type A

PubMed Central

Gerwing, Julia; Dolman, Claude E.; Bains, Hardial S.

1965-01-01

Gerwing, Julia (The University of British Columbia, Vancouver, B.C., Canada), Claude E. Dolman, and Hardial S. Bains. Isolation and characterization of a toxic moiety of low molecular weight from Clostridium botulinum type A. J. Bacteriol. 89:1383–1386. 1965.—A toxic moiety of low molecular weight has been isolated from a type A strain of Clostridium botulinum, by a method involving ammonium sulfate precipitation and elution through diethylaminoethyl cellulose at pH 5.6. By means of electrophoresis and ultracentrifugation, the toxic substance was shown to be homogeneous; a molecular weight of 12,200 was calculated. Images PMID:14293025

Synthesis of prostaglandin and phytoprostane B1 via regioselective intermolecular Pauson-Khand reactions.

PubMed

Vázquez-Romero, Ana; Cárdenas, Lydia; Blasi, Emma; Verdaguer, Xavier; Riera, Antoni

2009-07-16

A new approach to the synthesis of prostaglandin and phytoprostanes B(1) is described. The key step is an intermolecular Pauson-Khand reaction between a silyl-protected propargyl acetylene and ethylene. This reaction, promoted by NMO in the presence of 4 A molecular sieves, afforded the 3-tert-butyldimethylsilyloxymethyl-2-substituted-cyclopent-2-en-1-ones (III) in good yield and with complete regioselectivity. Deprotection of the silyl ether, followed by Swern oxidation, gave 3-formyl-2-substituted-cyclopent-2-en-1-ones (II). Julia olefination of the aldehydes II with the suitable chiral sulfone enabled preparation of PPB(1) type I and PGB(1).

On the formulation of D=11 supergravity and the composite nature of its three-form gauge field

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bandos, Igor A.; Institute for Theoretical Physics, NSC 'Kharkov Institute of Physics and Technology', UA61108, Kharkov; Azcarraga, Jose A. de

2005-05-01

The underlying gauge group structure of the D=11 Cremmer-Julia-Scherk supergravity becomes manifest when its three-form field A{sub 3} is expressed through a set of one-form gauge fields, B1a1a2, B1a1...a5, {eta}{sub 1{alpha}}, and E{sup a}, {psi}{sup {alpha}}. These are associated with the generators of the elements of a family of enlarged supersymmetry algebras E-bar (528 vertical bar 32+32)(s) parametrized by a real number s. We study in detail the composite structure of A{sub 3} extending previous results by D'Auria and Fre, stress the equivalence of the above problem to the trivialization of a standard supersymmetry algebra E(11 vertical bar 32) cohomologymore » four-cocycle on the enlarged E-bar (528 vertical bar 32+32)(s) superalgebras, and discuss its possible dynamical consequences. To this aim we consider the properties of the first order supergravity action with a composite A{sub 3} field and find the set of extra gauge symmetries that guarantee that the field theoretical degrees of freedom of the theory remain the same as with a fundamental A{sub 3}. The extra gauge symmetries are also present in the so-called rheonomic treatment of the first order D=11 supergravity action when A{sub 3} is composite. Our considerations on the composite structure of A{sub 3} provide one more application of the idea that there exists an extended superspace coordinates/fields correspondence. They also suggest that there is a possible embedding of D=11 supergravity into a theory defined on the enlarged superspace {sigma}-bar (528 vertical bar 32+32)(s)« less

Quantum state matching of qubits via measurement-induced nonlinear transformations

NASA Astrophysics Data System (ADS)

Kálmán, Orsolya; Kiss, Tamás

2018-03-01

We consider the task of deciding whether an unknown qubit state falls in a prescribed neighborhood of a reference state. We assume that several copies of the unknown state are given and apply a unitary operation pairwise on them combined with a postselection scheme conditioned on the measurement result obtained on one of the qubits of the pair. The resulting transformation is a deterministic, nonlinear, chaotic map in the Hilbert space. We derive a class of these transformations capable of orthogonalizing nonorthogonal qubit states after a few iterations. These nonlinear maps orthogonalize states which correspond to the two different convergence regions of the nonlinear map. Based on the analysis of the border (the so-called Julia set) between the two regions of convergence, we show that it is always possible to find a map capable of deciding whether an unknown state is within a neighborhood of fixed radius around a desired quantum state. We analyze which one- and two-qubit operations would physically realize the scheme. It is possible to find a single two-qubit unitary gate for each map or, alternatively, a universal special two-qubit gate together with single-qubit gates in order to carry out the task. We note that it is enough to have a single physical realization of the required gates due to the iterative nature of the scheme.

Polynomiography and Chaos

NASA Astrophysics Data System (ADS)

Kalantari, Bahman

Polynomiography is the algorithmic visualization of iterative systems for computing roots of a complex polynomial. It is well known that iterations of a rational function in the complex plane result in chaotic behavior near its Julia set. In one scheme of computing polynomiography for a given polynomial p(z), we select an individual member from the Basic Family, an infinite fundamental family of rational iteration functions that in particular include Newton's. Polynomiography is an excellent means for observing, understanding, and comparing chaotic behavior for variety of iterative systems. Other iterative schemes in polynomiography are possible and result in chaotic behavior of different kinds. In another scheme, the Basic Family is collectively applied to p(z) and the iterates for any seed in the Voronoi cell of a root converge to that root. Polynomiography reveals chaotic behavior of another kind near the boundary of the Voronoi diagram of the roots. We also describe a novel Newton-Ellipsoid iterative system with its own chaos and exhibit images demonstrating polynomiographies of chaotic behavior of different kinds. Finally, we consider chaos for the more general case of polynomiography of complex analytic functions. On the one hand polynomiography is a powerful medium capable of demonstrating chaos in different forms, it is educationally instructive to students and researchers, also it gives rise to numerous research problems. On the other hand, it is a medium resulting in images with enormous aesthetic appeal to general audiences.

PNNL researcher explores behavior of complex molecules

DOE Office of Scientific and Technical Information (OSTI.GOV)

Manke, Kristin L.

2007-11-19

From cold winters in St. Petersburg, Russia, to sweltering summers in southeastern Washington State, Dr. Julia Laskin’s career in science has been an interesting journey. Her latest trip landed her on the steps of the White House for a photo-op with the President. Laskin received the Presidential Early Career Award for Scientists and Engineers for her research on the fundamental aspects of the reaction kinetics and dynamics of activating and dissociating complex molecular ions. Her work at Pacific Northwest National Laboratory provides a basis for the development of analytical techniques for improved characterization of synthetic and natural polymers, petroleum, biofuelsmore » and other complex samples using mass spectrometry.« less

Anisotropy in the Arrival Directions of Ultrahigh-Energy Cosmic Rays

NASA Astrophysics Data System (ADS)

Villaseñor, Luis

2017-06-01

In this article we illustrate, in an interactive way, the analysis and visualization of anisotropy properties in the arrival directions of ultrahigh-energy cosmic rays detected by the Telescope Array and the Pierre Auger experiments by using data released by both collaborations. We describe the use of several programs that we have written in Python and Julia languages for this purpose. We also discuss the potential sources and analyse the effect of correcting the arrival directions to take into account the deflections of the cosmic rays by the magnetic field of our galaxy for one specific model of the galactic magnetic field under several assumptions about the composition of the primary cosmic rays.

London equation for monodromy inflation

NASA Astrophysics Data System (ADS)

Kaloper, Nemanja; Lawrence, Albion

2017-03-01

We focus on the massive gauge theory formulation of axion monodromy inflation. We argue that a gauge symmetry hidden in these models is the key mechanism protecting inflation from dangerous field theory and quantum gravity corrections. The effective theory of large-field inflation is dual to a massive U (1 ) 4-form gauge theory, which is similar to a massive gauge theory description of superconductivity. The gauge theory explicitly realizes the old Julia-Toulouse proposal for a low-energy description of a gauge theory in a defect condensate. While we work mostly with the example of quadratic axion potential induced by flux monodromy, we discuss how other types of potentials can arise from the inclusion of gauge-invariant corrections to the theory.

E11, brane dynamics and duality symmetries

NASA Astrophysics Data System (ADS)

West, Peter

2018-05-01

Following arXiv:hep-th/0412336 we use the nonlinear realisation of the semi-direct product of E11 and its vector representation to construct brane dynamics. The brane moves through a space-time which arises in the nonlinear realisation from the vector representation and it contains the usual embedding coordinates as well as the worldvolume fields. The resulting equations of motion are first order in derivatives and can be thought of as duality relations. Each brane carries the full E11 symmetry and so the Cremmer-Julia duality symmetries. We apply this theory to find the dynamics of the IIA and IIB strings, the M2 and M5 branes, the IIB D3 brane as well as the one and two branes in seven dimensions.

Searching for neurological diseases in the Julio-Claudian dynasty of the Roman Empire.

PubMed

Camargo, Carlos Henrique Ferreira; Teive, Hélio Afonso Ghizoni

2018-01-01

The gens Julia was one of the oldest families in ancient Rome, whose members reached the highest positions of power. They made history because Julius Caesar, perpetual dictator, great-uncle of the first emperor, Augustus, passed his name on to the Julio-Claudian dynasty with the emperors Tiberius, Caligula, Claudius and Nero. Descriptions of the diseases of these emperors and some of his family members may indicate diagnoses such as epilepsy, dystonia, dementia, encephalitis, neurosyphilis, peripheral neuropathies, dyslexia, migraine and sleep disorders. In the historical context of ancient Rome, the possibility of infectious diseases related to the libertine way of life is quite large. However, there is a possibility that some of these diseases occurred from genetic transmission.

Gossip.

PubMed

1994-09-07

• It's easy to mock, I know, and we all have our own little peculiarities, but there's a new magazine out aimed specifically at collectors of phone cards. Yes, Publishing reports that Telecard Collector International is about to hit the streets, complete with the obligatory glamorous woman on the front to boost sales. In this case, the woman is Julia Swalha - Saffi, in Absolutely Fabulous - who is obviously a phonecard fan. (Whatever would Patsy say?) But titter ye not. 'Overall, this is an infuriatingly compulsive read,' says Publishing. And with some cards apparently reaching asking prices of £950, the anorak brigade obviously knows a thing or two. But before you start hanging on to all those cards you feed into the nursing home phone, be warned. They apparently increase in value if they are unused. Fabulous.

[Violence against women because of their being women. Myths and stereotypes perpetuated in "El Vocero"].

PubMed

Maldonado, M A

1990-04-01

A model is presented for examining the myths, sterotypes, and prejudices about women that are presented daily to our society through the popular press, specifically The Vocero. The journalistic vocabulary and style, the interpretation of the information offered and the significance of the information omitted in the Vocero articles are examined. The myths and stereotypes of women that are repeated consistently in these articles are correlated with the clinical experience of the Puerto Rico Rape Crisis Center and Casa Julia Battered Woman's Shelter. Finally, this process of popular education is presented as an important determinant for violence against women in Puerto Rico and for the prevalence of a high degree of social apathy and indifference to the problem in our community.

The Sun-Earth connect 2: Modelling patterns of a fractal Sun in time and space using the fine structure constant

NASA Astrophysics Data System (ADS)

Baker, Robert G. V.

2017-02-01

Self-similar matrices of the fine structure constant of solar electromagnetic force and its inverse, multiplied by the Carrington synodic rotation, have been previously shown to account for at least 98% of the top one hundred significant frequencies and periodicities observed in the ACRIM composite irradiance satellite measurement and the terrestrial 10.7cm Penticton Adjusted Daily Flux data sets. This self-similarity allows for the development of a time-space differential equation (DE) where the solutions define a solar model for transmissions through the core, radiative, tachocline, convective and coronal zones with some encouraging empirical and theoretical results. The DE assumes a fundamental complex oscillation in the solar core and that time at the tachocline is smeared with real and imaginary constructs. The resulting solutions simulate for tachocline transmission, the solar cycle where time-line trajectories either 'loop' as Hermite polynomials for an active Sun or 'tail' as complementary error functions for a passive Sun. Further, a mechanism that allows for the stable energy transmission through the tachocline is explored and the model predicts the initial exponential coronal heating from nanoflare supercharging. The twisting of the field at the tachocline is then described as a quaternion within which neutrinos can oscillate. The resulting fractal bubbles are simulated as a Julia Set which can then aggregate from nanoflares into solar flares and prominences. Empirical examples demonstrate that time and space fractals are important constructs in understanding the behaviour of the Sun, from the impact on climate and biological histories on Earth, to the fractal influence on the spatial distributions of the solar system. The research suggests that there is a fractal clock underpinning solar frequencies in packages defined by the fine structure constant, where magnetic flipping and irradiance fluctuations at phase changes, have periodically impacted on the Earth and the rest of the solar system since time immemorial.

CauseMap: fast inference of causality from complex time series.

PubMed

Maher, M Cyrus; Hernandez, Ryan D

2015-01-01

Background. Establishing health-related causal relationships is a central pursuit in biomedical research. Yet, the interdependent non-linearity of biological systems renders causal dynamics laborious and at times impractical to disentangle. This pursuit is further impeded by the dearth of time series that are sufficiently long to observe and understand recurrent patterns of flux. However, as data generation costs plummet and technologies like wearable devices democratize data collection, we anticipate a coming surge in the availability of biomedically-relevant time series data. Given the life-saving potential of these burgeoning resources, it is critical to invest in the development of open source software tools that are capable of drawing meaningful insight from vast amounts of time series data. Results. Here we present CauseMap, the first open source implementation of convergent cross mapping (CCM), a method for establishing causality from long time series data (≳25 observations). Compared to existing time series methods, CCM has the advantage of being model-free and robust to unmeasured confounding that could otherwise induce spurious associations. CCM builds on Takens' Theorem, a well-established result from dynamical systems theory that requires only mild assumptions. This theorem allows us to reconstruct high dimensional system dynamics using a time series of only a single variable. These reconstructions can be thought of as shadows of the true causal system. If reconstructed shadows can predict points from opposing time series, we can infer that the corresponding variables are providing views of the same causal system, and so are causally related. Unlike traditional metrics, this test can establish the directionality of causation, even in the presence of feedback loops. Furthermore, since CCM can extract causal relationships from times series of, e.g., a single individual, it may be a valuable tool to personalized medicine. We implement CCM in Julia, a high-performance programming language designed for facile technical computing. Our software package, CauseMap, is platform-independent and freely available as an official Julia package. Conclusions. CauseMap is an efficient implementation of a state-of-the-art algorithm for detecting causality from time series data. We believe this tool will be a valuable resource for biomedical research and personalized medicine.

On the dual equivalence of the self-dual and topologically massive /p-form models

NASA Astrophysics Data System (ADS)

Menezes, R.; Nascimento, J. R. S.; Ribeiro, R. F.; Wotzasek, C.

2003-07-01

We study the duality symmetry in p-form models containing a generalized Bq∧Fp+1 term in spacetime manifolds of arbitrary dimensions. The equivalence between the Bq∧Fp+1 self-dual (SDB∧F) and the Bq∧Fp+1 topologically massive (TMB∧F) models is established using a gauge embedding procedure, including the minimal coupling to conserved charged matter current. The minimal coupling adopted for both tensor fields in the self-dual representation is transformed into a non-minimal magnetic like coupling in the topologically massive representation but with the currents swapped. It is known that to establish this equivalence a current-current interaction term is needed to render the matter sector unchanged. We show that both terms arise naturally from the embedding adopted. Comparison with Higgs/Julia-Toulouse duality is established.

Addressing the psychosocial wellbeing of teenage children of cancer patients and survivors.

PubMed

Annunziata, Maria Antonietta; Muzzatti, Barbara; Surbone, Antonella

2016-02-01

Thomas is 13 years old. His parents report a sharp decline in his school grades caused, according to his teachers' opinions, by listlessness and lack of concentration. The parents of Julia, 16 years old, describe her as restless, evasive, isolated, and withdrawn from others and from her usual activities. Linda, 18 years old, is described by her parents as indecisive, uncertain, and almost lethargic. Normally resolute and a high academic achiever, she appears locked in herself, unable to make choices. We first learned about them through the accounts of their concerned parents. Claire, 19 years old, lost weight and exercised hard enough to induce amenorrhea after her young mother underwent treatment for breast cancer, including antihormonal treatment. These four teenagers have in common a parent diagnosed with cancer, undergoing or having just completed treatment.

Complexity and approximability of quantified and stochastic constraint satisfaction problems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hunt, H. B.; Stearns, R. L.; Marathe, M. V.

2001-01-01

Let D be an arbitrary (not necessarily finite) nonempty set, let C be a finite set of constant symbols denoting arbitrary elements of D, and let S be an arbitrary finite set of finite-arity relations on D. We denote the problem of determining the satisfiability of finite conjunctions of relations in S applied to variables (to variables and symbols in C) by SAT(S) (by SAT{sub c}(S)). Here, we study simultaneously the complexity of and the existence of efficient approximation algorithms for a number of variants of the problems SAT(S) and SAT{sub c}(S), and for many different D, C, and S.more » These problem variants include decision and optimization problems, for formulas, quantified formulas stochastically-quantified formulas. We denote these problems by Q-SAT(S), MAX-Q-SAT(S), S-SAT(S), MAX-S-SAT(S) MAX-NSF-Q-SAT(S) and MAX-NSF-S-SAT(S). The main contribution is the development of a unified predictive theory for characterizing the the complexity of these problems. Our unified approach is based on the following basic two basic concepts: (i) strongly-local replacements/reductions and (ii) relational/algebraic representability. Let k {ge} 2. Let S be a finite set of finite-arity relations on {Sigma}{sub k} with the following condition on S: All finite arity relations on {Sigma}{sub k} can be represented as finite existentially-quantified conjunctions of relations in S applied to variables (to variables and constant symbols in C), Then we prove the following new results: (1) The problems SAT(S) and SAT{sub c}(S) are both NQL-complete and {le}{sub logn}{sup bw}-complete for NP. (2) The problems Q-SAT(S), Q-SAT{sub c}(S), are PSPACE-complete. Letting k = 2, the problem S-SAT(S) and S-SAT{sub c}(S) are PSPACE-complete. (3) {exists} {epsilon} > 0 for which approximating the problems MAX-Q-SAT(S) within {epsilon} times optimum is PSPACE-hard. Letting k =: 2, {exists} {epsilon} > 0 for which approximating the problems MAX-S-SAT(S) within {epsilon} times optimum is PSPACE-hard. (4) {forall} {epsilon} > 0 the problems MAX-NSF-Q-SAT(S) and MAX-NSF-S-SAT(S), are PSPACE-hard to approximate within a factor of n{sup {epsilon}} times optimum. These results significantly extend the earlier results by (i) Papadimitriou [Pa851] on complexity of stochastic satisfiability, (ii) Condon, Feigenbaum, Lund and Shor [CF+93, CF+94] by identifying natural classes of PSPACE-hard optimization problems with provably PSPACE-hard {epsilon}-approximation problems. Moreover, most of our results hold not just for Boolean relations: most previous results were done only in the context of Boolean domains. The results also constitute as a significant step towards obtaining a dichotomy theorems for the problems MAX-S-SAT(S) and MAX-Q-SAT(S): a research area of recent interest [CF+93, CF+94, Cr95, KSW97, LMP99].« less

A computationally efficient parallel Levenberg-Marquardt algorithm for highly parameterized inverse model analyses

NASA Astrophysics Data System (ADS)

Lin, Youzuo; O'Malley, Daniel; Vesselinov, Velimir V.

2016-09-01

Inverse modeling seeks model parameters given a set of observations. However, for practical problems because the number of measurements is often large and the model parameters are also numerous, conventional methods for inverse modeling can be computationally expensive. We have developed a new, computationally efficient parallel Levenberg-Marquardt method for solving inverse modeling problems with a highly parameterized model space. Levenberg-Marquardt methods require the solution of a linear system of equations which can be prohibitively expensive to compute for moderate to large-scale problems. Our novel method projects the original linear problem down to a Krylov subspace such that the dimensionality of the problem can be significantly reduced. Furthermore, we store the Krylov subspace computed when using the first damping parameter and recycle the subspace for the subsequent damping parameters. The efficiency of our new inverse modeling algorithm is significantly improved using these computational techniques. We apply this new inverse modeling method to invert for random transmissivity fields in 2-D and a random hydraulic conductivity field in 3-D. Our algorithm is fast enough to solve for the distributed model parameters (transmissivity) in the model domain. The algorithm is coded in Julia and implemented in the MADS computational framework (http://mads.lanl.gov). By comparing with Levenberg-Marquardt methods using standard linear inversion techniques such as QR or SVD methods, our Levenberg-Marquardt method yields a speed-up ratio on the order of ˜101 to ˜102 in a multicore computational environment. Therefore, our new inverse modeling method is a powerful tool for characterizing subsurface heterogeneity for moderate to large-scale problems.

Origin of petroporphyrins. 2. Evidence from stable carbon isotopes

NASA Technical Reports Server (NTRS)

Boreham, C. J.; Fookes, C. J.; Popp, B. N.; Hayes, J. M.

1990-01-01

Compared with the carbon-13 isotopic composition of the ubiquitous C32DPEP (DPEP, deoxophylloerythroetioporphyrin) the heavy but equivalent carbon-13 isotopic composition for the porphyrin structures 15(2)-methyl-15,17-ethano-17-nor-H-C30DPEP and 15,17-butano-, 13,15-ethano-13(2),17-propano-, and 13(1)-methyl-13,15-ethano-13(2),17-propanoporphyrin suggests a common precursor, presumably chlorophyll c, for these petroporphyrins isolated from the marine Julia Creek oil shale and the lacustrine Condor oil shale. Similarly, the heavy but variable carbon-13 isotopic composition of 7-nor-H-C31DPEP compared with C32DPEP is consistent with an origin from both chlorophyll b and chlorophyll c3. The equivalent carbon-13 isotopic composition for 13(2)-methyl-C33DPEP compared with C32DPEP suggests a common origin resulting from a weighted average of chlorophyll inputs.

Adolescent Daughters and Ritual Abjection: Narrative Analysis of Self-injury in Four US Films.

PubMed

Bareiss, Warren

2017-09-01

Media representations of illnesses, particularly those associated with stigma such as non-suicidal self-injury (NSSI), not only define health conditions for mass audiences, but generally do so in ways that are consistent with dominant ideologies. This article examines the construction of non-suicidal self-injury as practiced by female adolescents and young adults in four US films: Girl, Interrupted, Painful Secrets, Prozac Nation, and Thirteen. The methodology used to examine the films' narrative structure is Kenneth Burke's dramatism, while Julia Kristeva's concept of abjection informs the analysis. On one hand, a paradigmatic reading suggests that the films frame self-injury as resistance to repressive maternal domination of female adolescents. On the other hand, syntagmatic analysis reveals a privileged response to NSSI in the form of pacification administered by psychotherapists functioning as the return of the phallic-mother fantasy.

The One or the Many: Quantified Subjectivity and Aggregated Uniqueness in Qualitative Rehabilitation Research.

PubMed

Juritzen, Truls I; Soberg, Helene L; Røe, Cecilie; Saebu, Martin; Engen, Grace; Bliksvaer, Trond; Engebretsen, Eivind

2017-01-01

This article aims to identify and critically assess qualitative intervention studies of rehabilitation processes that target young adults. By applying a meta-epistemological approach inspired by the works of Michel Foucault and Julia Kristeva, we examine how the included studies present qualitative knowledge and whether they adhere to their own stated principles of qualitative knowledge. Through their stated aims and theoretical framing, the articles draw attention to individual processes of meaning making. Nonetheless, we find that the articles to a great extent emphasize frequencies of the qualitative data they present. Individual processes and experiences are subject to subdivisions and categorization and transformed into manageable objects of knowledge. In conclusion, these studies, with one important exception, contribute to self-marginalization of the knowledge they themselves promote: They undermine the uniqueness of the qualitative knowledge they proclaim by focusing on frequency and the general patterns and categories encompassing the unique. © The Author(s) 2016.

Outage management and health physics issue, 2009

DOE Office of Scientific and Technical Information (OSTI.GOV)

Agnihotri, Newal

2009-05-15

The focus of the May-June issue is on outage management and health physics. Major articles include the following: Planning and scheduling to minimize refueling outage, by Pat McKenna, AmerenUE; Prioritizing safety, quality and schedule, by Tom Sharkey, Dominion; Benchmarking to high standards, by Margie Jepson, Energy Nuclear; Benchmarking against U.S. standards, by Magnox North, United Kingdom; Enabling suppliers for new build activity, by Marcus Harrington, GE Hitachi Nuclear Energy; Identifying, cultivating and qualifying suppliers, by Thomas E. Silva, AREVA NP; Creating new U.S. jobs, by Francois Martineau, Areva NP. Industry innovation articles include: MSL Acoustic source load reduction, by Amirmore » Shahkarami, Exelon Nuclear; Dual Methodology NDE of CRDM nozzles, by Michael Stark, Dominion Nuclear; and Electronic circuit board testing, by James Amundsen, FirstEnergy Nuclear Operating Company. The plant profile article is titled The future is now, by Julia Milstead, Progress Energy Service Company, LLC.« less

Sexing Berlin?

PubMed

Dahlke, Birgit

2011-01-01

Berlin has always been a literary space of extremely diverse political and cultural projections. This essay investigates why after the unification of East and West Berlin the city has been imagined as a play zone of sexual self-fulfilment by authors such as Inka Parei, Tanja Dückers, Kathrin Röggla, Judith Hermann and Julia Franck. Have such erotic adventures replaced political vision in our post-utopian decade? What is the purpose of the laboured allegorisation of the fall of the wall in Durs Grünbein's essays or in the novels of Katja Lange-Müller and Thomas Hettche? The sexification of historical and political processes recalls similar stereotypes in the East German literature of the 1980s: the metropolis as a whore in works by Heiner Müller or Wolf Biermann, but also by younger authors of the independent literary scene in Berlin like Uwe Kolbe or Frank-Wolf Matthies.

A boy with oral hair: case report.

PubMed

Agha-Hosseini, Farzaneh; Etesam, Farideh; Rohani, Bita

2007-09-01

In personal communication we have never seen or heard of hair being detected in the oral cavity. Even Julia Pastrana, the famous "Bearded Lady" of the 1800's, had no record of oral hair, although her entire body was covered with hair. Extensive records of her oral condition, including plaster models of her teeth have been preserved in the Odontological Museum of the Royal College of Surgeons in London city. She suffered from excessive gingival hyperplasia, but apparently no hair existed within the mouth. Some rodents have oral hair as a normal occurrence, but the condition is apparently limited in the animal kingdom. A case of hair occurring naturally in the mouth has been reported only twice previously. A third case of this rare anomaly is reported here. In this case, multiple hairs were found at the gingival sulcus in the labial, buccal, lingual and palatal tooth surfaces in an 11-year-old boy.

Chemoenzymatic synthesis of statine side chain building blocks and application in the total synthesis of the cholesterol-lowering compound solistatin.

PubMed

Rieder, Oliver; Wolberg, Michael; Foegen, Silke E; Müller, Michael

2017-09-20

The synthesis and enzymatic reduction of several 6-substituted dioxohexanoates are presented. Two-step syntheses of tert-butyl 6-bromo-3,5-dioxohexanoate and the corresponding 6-hydroxy compound have been achieved in 89% and 59% yield, respectively. Regio- and enantioselective reduction of these diketones and of the 6-chloro derivative with alcohol dehydrogenase from Lactobacillus brevis (LBADH) gave the (5S)-5-hydroxy-3-oxo products with enantiomeric excesses of 91%, 98.4%, and >99.5%, respectively. Chain elongation of the reduction products by one carbon via cyanide addition, and by more than one carbon by Julia-Kocienski olefination, gave access to well-established statine side-chain building blocks. Application in the synthesis of the cholesterol-lowering natural compound solistatin is given. Copyright © 2017 Elsevier B.V. All rights reserved.

Theorizing waste in abortion and fetal ovarian tissue use.

PubMed

Arris, Rachel

2003-01-01

This article explores the theoretical implications of the concept of waste as it specifically relates to arguments in favour of fetal ovarian tissue use as a source of donor eggs. The author begins by discussing medico-scientific constructions of women's reproductive bodies as wasteful. The article explores the works of Drucilla Cornell on bodily borders, Julia Kristeva on abjection, and Mary Douglas on pollution to develop a nuanced understanding of the relations between waste, women's reproductivity, and abortion in North American mainstream and medico-scientific cultures. This layered reading of waste and abortion deconstructs a significant assumption of arguments in favour of fetal ovarian tissue use as ethical--that such tissue is just "waste." The author suggests that theorizing waste this way may contribute to ethical analyses of uses of other reproductive materials (that is, embryos) that are supported, in part, by an assumption that those materials would otherwise be "wasted."

A computationally efficient parallel Levenberg-Marquardt algorithm for highly parameterized inverse model analyses

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lin, Youzuo; O'Malley, Daniel; Vesselinov, Velimir V.

Inverse modeling seeks model parameters given a set of observations. However, for practical problems because the number of measurements is often large and the model parameters are also numerous, conventional methods for inverse modeling can be computationally expensive. We have developed a new, computationally-efficient parallel Levenberg-Marquardt method for solving inverse modeling problems with a highly parameterized model space. Levenberg-Marquardt methods require the solution of a linear system of equations which can be prohibitively expensive to compute for moderate to large-scale problems. Our novel method projects the original linear problem down to a Krylov subspace, such that the dimensionality of themore » problem can be significantly reduced. Furthermore, we store the Krylov subspace computed when using the first damping parameter and recycle the subspace for the subsequent damping parameters. The efficiency of our new inverse modeling algorithm is significantly improved using these computational techniques. We apply this new inverse modeling method to invert for random transmissivity fields in 2D and a random hydraulic conductivity field in 3D. Our algorithm is fast enough to solve for the distributed model parameters (transmissivity) in the model domain. The algorithm is coded in Julia and implemented in the MADS computational framework (http://mads.lanl.gov). By comparing with Levenberg-Marquardt methods using standard linear inversion techniques such as QR or SVD methods, our Levenberg-Marquardt method yields a speed-up ratio on the order of ~10 1 to ~10 2 in a multi-core computational environment. Furthermore, our new inverse modeling method is a powerful tool for characterizing subsurface heterogeneity for moderate- to large-scale problems.« less

ARK: Aggregation of Reads by K-Means for Estimation of Bacterial Community Composition.

PubMed

Koslicki, David; Chatterjee, Saikat; Shahrivar, Damon; Walker, Alan W; Francis, Suzanna C; Fraser, Louise J; Vehkaperä, Mikko; Lan, Yueheng; Corander, Jukka

2015-01-01

Estimation of bacterial community composition from high-throughput sequenced 16S rRNA gene amplicons is a key task in microbial ecology. Since the sequence data from each sample typically consist of a large number of reads and are adversely impacted by different levels of biological and technical noise, accurate analysis of such large datasets is challenging. There has been a recent surge of interest in using compressed sensing inspired and convex-optimization based methods to solve the estimation problem for bacterial community composition. These methods typically rely on summarizing the sequence data by frequencies of low-order k-mers and matching this information statistically with a taxonomically structured database. Here we show that the accuracy of the resulting community composition estimates can be substantially improved by aggregating the reads from a sample with an unsupervised machine learning approach prior to the estimation phase. The aggregation of reads is a pre-processing approach where we use a standard K-means clustering algorithm that partitions a large set of reads into subsets with reasonable computational cost to provide several vectors of first order statistics instead of only single statistical summarization in terms of k-mer frequencies. The output of the clustering is then processed further to obtain the final estimate for each sample. The resulting method is called Aggregation of Reads by K-means (ARK), and it is based on a statistical argument via mixture density formulation. ARK is found to improve the fidelity and robustness of several recently introduced methods, with only a modest increase in computational complexity. An open source, platform-independent implementation of the method in the Julia programming language is freely available at https://github.com/dkoslicki/ARK. A Matlab implementation is available at http://www.ee.kth.se/ctsoftware.

A computationally efficient parallel Levenberg-Marquardt algorithm for highly parameterized inverse model analyses

DOE PAGES

Lin, Youzuo; O'Malley, Daniel; Vesselinov, Velimir V.

2016-09-01

Inverse modeling seeks model parameters given a set of observations. However, for practical problems because the number of measurements is often large and the model parameters are also numerous, conventional methods for inverse modeling can be computationally expensive. We have developed a new, computationally-efficient parallel Levenberg-Marquardt method for solving inverse modeling problems with a highly parameterized model space. Levenberg-Marquardt methods require the solution of a linear system of equations which can be prohibitively expensive to compute for moderate to large-scale problems. Our novel method projects the original linear problem down to a Krylov subspace, such that the dimensionality of themore » problem can be significantly reduced. Furthermore, we store the Krylov subspace computed when using the first damping parameter and recycle the subspace for the subsequent damping parameters. The efficiency of our new inverse modeling algorithm is significantly improved using these computational techniques. We apply this new inverse modeling method to invert for random transmissivity fields in 2D and a random hydraulic conductivity field in 3D. Our algorithm is fast enough to solve for the distributed model parameters (transmissivity) in the model domain. The algorithm is coded in Julia and implemented in the MADS computational framework (http://mads.lanl.gov). By comparing with Levenberg-Marquardt methods using standard linear inversion techniques such as QR or SVD methods, our Levenberg-Marquardt method yields a speed-up ratio on the order of ~10 1 to ~10 2 in a multi-core computational environment. Furthermore, our new inverse modeling method is a powerful tool for characterizing subsurface heterogeneity for moderate- to large-scale problems.« less

Quark Matter 2011 (QM11) Quark Matter 2011 (QM11)

NASA Astrophysics Data System (ADS)

2011-12-01

International Advisory Committee Antinori, FedericoPaic, Guy Braun-Munzinger, PeterPajares, Carlos Cifarelli, LuisaPeitzmann, Thomas Erazmus, BarbaraRedlich, Krzysztof Eskola, KariRiccati, Lodovico Gaardhøje, Jens JørgenRoland, Gunther Gale, CharlesRoy, Christelle Gelis, FrancoisSchukraft, Jürgen Giubellino, PaoloSinha, Bikash Greiner, CarstenSrivastava, Dinesh Gyulassy, MiklosStachel, Johanna Harris, JohnSteinberg, Peter Hatsuda, TetsuoStroth, Joachim Heinz, UlrichSugitate, Toru Jacak, BarbaraTserruya, Itzhak Karsch, FrithjofVelkovska, Julia Kharzeev, DimaWang, Enke Kodama, TakeshiWang, Xin, Nian Lévai, PéterWessels, Johannes Manko, VladislavXu, Nu Müller, BerndtZajc, William Ollitrault, Jean-Yves Organizing Committee Arleo, FrancoisDupieux, Pascal Bastid, NicoleFurget, Christophe Bourgeois, Marie-LaureGranier de Cassagnac, Raphael Bregant, MarcoGuernane, Rachid Carminati, FedericoHervet, Carnita Castillo, JavierKuhn, Christian Cheynis, BrigitteOlivier, Nathalie Conesa, DelValle, Zaida Connor, MichelleRenshall, Lucy Crochet, PhilippeSuire, Christophe Delagrange, HuguesTihinen, Ulla Program Committee Schutz, Yves (Chair)Baldisseri, Alberto Wiedemann, Urs (co-Chair)Safarik, Karel Aurenche, Patrick

Fractal Geometry in the Arts: AN Overview across the Different Cultures

NASA Astrophysics Data System (ADS)

Sala, Nicoletta

Fractal, in mathematics, is a geometric shape that is complex and detailed in structure at any level of magnification. The word "fractal" was coined less than thirty years ago by one of history's most creative and mathematicians, Benoit Mandelbrot, whose work, The Fractal Geometry of Nature, first introduced and explained concepts underlying this new vision of the geometry. Although other mathematical thinkers like Georg Cantor (1845-1918), Felix Hausdorff (1868-1942), Gaston Julia (1893-1978), Helge von Koch (1870-1924), Giuseppe Peano (1858-1932), Lewis Richardson (1891-1953), Waclaw Sierpinski (1882-1969) and others had attained isolated insights of fractal understanding, such ideas were largely ignored until Mandelbrot's genius forged them at a single blow into a gorgeously coherent and fascinating discipline. Fractal geometry is applied in different field now: engineering, physics, chemistry, biology, and architecture. The aim of this paper is to introduce an approach where the arts are analysed using a fractal point of view.

The effects of parameter variation on MSET models of the Crystal River-3 feedwater flow system.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Miron, A.

1998-04-01

In this paper we develop further the results reported in Reference 1 to include a systematic study of the effects of varying MSET models and model parameters for the Crystal River-3 (CR) feedwater flow system The study used archived CR process computer files from November 1-December 15, 1993 that were provided by Florida Power Corporation engineers Fairman Bockhorst and Brook Julias. The results support the conclusion that an optimal MSET model, properly trained and deriving its inputs in real-time from no more than 25 of the sensor signals normally provided to a PWR plant process computer, should be able tomore » reliably detect anomalous variations in the feedwater flow venturis of less than 0.1% and in the absence of a venturi sensor signal should be able to generate a virtual signal that will be within 0.1% of the correct value of the missing signal.« less

Hydrogeology and history of Washington, D.C.

NASA Astrophysics Data System (ADS)

For Washington, D.C., inhabitants or anyone planning a trip to the area, interesting information on the hydrology, geology, and natural and cultural history is available.To provide geographic and historical background for field trips in the area, a book was published for the 28th International Geological Congress, held in Washington in July 1989. Geology, Hydrology, and History of the Washington, D.C. Area, edited by John E. Moore of the U.S. Geological Survey, Reston, Va., and Julia A. Jackson of the American Geological Institute, Alexandria, Va., describes such interesting items as the Washington Canal, which ran from the Potomac River to the Capitol and is now Constitution Avenue, and the Cabin John Aqueduct, where a 297-foot granite arch was the longest masonry arch in the world for 40 years. The aqueduct has carried water to Washington since 1863. The 114-page book contains many historic photographs and maps and can be purchased from the American Geological Institute, 4220 King Street, Alexandria, VA 22302-1507, tel. 703-379-2480.

Impact of Health Disclosure Laws on Health Information Exchanges

PubMed Central

Adjerid, Idris; Padman, Rema

2011-01-01

Health information exchanges (HIEs) are expected to facilitate data sharing between healthcare entities, thereby improving the efficiency and quality of care. Privacy concerns have been consistently cited as one of the primary challenges to HIE formation and success. Currently, it is unclear how privacy laws – in particular, legislation restricting the disclosure of health records – have shaped the development of HIEs. This preliminary study explores the landscape of state-level health privacy legislation and examines the impact of variations in such privacy and confidentiality laws on the progress of HIEs. We found that states with stronger privacy laws, limiting the disclosure of health information, had significantly more HIEs exchanging data and had fewer failed HIEs. We suggest that this counterintuitive finding may be explained by the more subtle benefits of such laws, such as increased confidence and trust of participants in an exchange. Other key contributors to this work are Alessandro Acquisti, Rahul Telang, and Julia Adler-Milstein PMID:22195054

'Nice girls don't carry knives': constructions of ambition in media coverage of Australia's first female prime minister.

PubMed

Hall, Lauren J; Donaghue, Ngaire

2013-12-01

Julia Gillard became the first female prime minister of Australia in 2010. This paper examines the various ways in which her success was constructed in the Australian print media in the days immediately following her elevation. In particular, we focus on how an issue that has long beset women aspiring to power and leadership - the so-called 'double bind' in which aspiring women leaders must display high competence and ambition in traditionally masculine domains while maintaining sufficient femininity so as not to be disliked - was constructed in this high-profile instance. We discuss the coverage in terms of its implications for the need to create an androgynized presentation of ambition, the continuing relevance of gender stereotypes, and the mixture of threat and opportunity provided to women taking positions on 'the glass cliff'. These issues remain crucially important for women aspiring to power and leadership in contemporary western societies. © 2012 The British Psychological Society.

HiC-spector: a matrix library for spectral and reproducibility analysis of Hi-C contact maps.

PubMed

Yan, Koon-Kiu; Yardimci, Galip Gürkan; Yan, Chengfei; Noble, William S; Gerstein, Mark

2017-07-15

Genome-wide proximity ligation based assays like Hi-C have opened a window to the 3D organization of the genome. In so doing, they present data structures that are different from conventional 1D signal tracks. To exploit the 2D nature of Hi-C contact maps, matrix techniques like spectral analysis are particularly useful. Here, we present HiC-spector, a collection of matrix-related functions for analyzing Hi-C contact maps. In particular, we introduce a novel reproducibility metric for quantifying the similarity between contact maps based on spectral decomposition. The metric successfully separates contact maps mapped from Hi-C data coming from biological replicates, pseudo-replicates and different cell types. Source code in Julia and Python, and detailed documentation is available at https://github.com/gersteinlab/HiC-spector . koonkiu.yan@gmail.com or mark@gersteinlab.org. Supplementary data are available at Bioinformatics online. © The Author(s) 2017. Published by Oxford University Press.

"And teach agony to sing": an afternoon with Eleanor Clarke Slagle.

PubMed

Bing, R K

1997-03-01

Using published works, archival correspondence, interviews with contemporaries, and historical commentary, an imagined conversation is presented between Eleanor Clarke Slagle (1871-1942) and three of her actual contemporaries. As a founder of the National Society for the Promotion of Occupational Therapy (later to become the American Occupational Therapy Association [AOTA] and a past-president and executive secretary of AOTA for 21 years, Slagle came in contact with a host of therapists as well as men and women who influenced her and the occupational therapy profession, most particularly Julia Lathrop, Adolf Meyer, William Rush Dunton, Jr., and Ida Sands. Emphasis is placed on some of her early life experiences; Hull House; and the evolution of the occupational therapy belief system, including occupations, curative work, and spiritual rehabilitation (i.e., self-respect, interests, ambition, happiness, economic usefulness, success). Special attention was taken to reflect Slagle's typical use of language and the vernacular of the mid-1930s. Extensive study was undertaken, through reading Slagle's published works, to remain true to her use of language.

High Resolution Velocity Structure in Eastern Turkey

NASA Astrophysics Data System (ADS)

Pasyanos, M. E.; Gok, R.; Zor, E.; Walter, W. R.

2004-12-01

We investigate the crust and upper mantle structure of eastern Turkey where the Anatolian, Arabian and Eurasian Plates meet, forming a complex tectonic regime. The Bitlis suture is a continental collision zone between the Anatolian plateau and the Arabian plate. Broadband data available through the Eastern Turkey Seismic Experiment (ETSE) provide a unique opportunity for studying the high resolution velocity structure of the region. Zor et al. (2003) found an average 46 km thick crust in the Anatolian plateau using a six-layered grid search inversion of the ETSE receiver functions. Receiver functions are sensitive to the velocity contrast of interfaces and the relative travel time of converted and reverberated waves between those interfaces. The interpretation of receiver functions alone, however, may result in an apparent depth-velocity trade-off [Ammon et al., 1990]. In order to improve upon this velocity model, we have combined the receiver functions with surface wave data using the joint inversion method of Julia et al. (2000). In this technique, the two sets of observations are combined into a single algebraic equation and each data set is weighted by an estimate of the uncertainty in the observations. The receiver functions are calculated using an iterative time-domain deconvolution technique. We also consider azimuthal changes in the receiver functions and have stacked them into different groups accordingly. We are improving our surface wave model by making Love and Rayleigh dispersion measurements at the ETSE stations and incorporating them into a regional group velocity model for periods between 10 and 100 seconds. Preliminary results indicate a strong trend in the long period group velocities toward the northeast, indicating slow upper mantle velocities in the area consistent with Pn, Sn and receiver function results. Starting models used for the joint inversions include both a 1-D model from a 12-ton dam shot recorded by ETSE [Gurbuz et al., 2004] and the models from the original receiver function inversions. We observe that the joint inversion results are independent of the starting model and converge to the same final model, with some differences compared to the original profiles. While we don't observe significant changes in the first order discontinuities of the model, such as Moho depth, we are better able to resolve features in the crust.

Beyond Phallic Domain: Female Otherness as a Resource for Liberation: Some Notes From Lacanian Psychoanalysis and Poststructuralist Feminism.

PubMed

Gonzalez-Barrientos, Marcela; Napolitano, Stefania

2015-06-01

The article explores the political derivations of psychoanalytical discourse on femininity, starting from the impact of Lacanian positions on feminist thought. The consideration of a dimension of absolute otherness of female sexuality, irreducible to masculinity and to a phallic domain--not-all phallic--theorized by Lacan in the 1970s, opens up many complex issues for the politics of women's liberation. It is a matter of living the absolute difference without either radically excluding it from the speakable or letting it be part of a romantic imagery of the otherness that perpetuates sexual hierarchy and, consequently, female subordination. Taking up the proposal of such authors as Julia Kristeva or Silvia Tubert, we suggest that the Lacanian theory offers the conceptual tools to shift from exclusion to re-volt, from the place of the Other as a pedestal for the Same to a political function of female otherness and of the "not-all" that it represents: a part of the Kultur and its difficulties, but not entangled in it to the point that it cannot bring any innovation.

Transforming Introductory Physics for Life Scientists: Researching the consequences for students

NASA Astrophysics Data System (ADS)

Turpen, Chandra

2011-10-01

In response to policy documents calling for dramatic changes in pre-medical and biology education [1-3], the physics and biology education research groups at the University of Maryland are rethinking how to teach physics to life science majors. As an interdisciplinary team, we are drastically reconsidering the physics topics relevant for these courses. We are designing new in-class tasks to engage students in using physical principles to explain aspects of biological phenomena where the physical principles are of consequence to the biological systems. We will present examples of such tasks as well as preliminary data on how students engage in these tasks. Lastly, we will share some barriers encountered in pursuing meaningful interdisciplinary education.[4pt] Co-authors: Edward F. Redish and Julia Svaboda [4pt] [1] National Research Council, Bio2010: Transforming Undergraduate Education for Future Research Biologists (NAP, 2003).[0pt] [2] AAMC-HHMI committee, Scientific Foundations for Future Physicians (AAMC, 2009).[0pt] [3] American Association for the Advancement of Science, Vision and Change in Undergraduate Biology Education: A Call to Action (AAAS, 2009).

Designing the Lunar Regolith Excavation Competition

NASA Technical Reports Server (NTRS)

Le, Christopher

2009-01-01

The project assigned this summer involves designing a lunar regolith mining robotics competition. This process involves consulting several assets available at the Kennedy Space Center. The process involves several steps. The first step is to determine the requirements for the competition. Once these requirements are determined, the dimensions of the playing field are drawn up, first by hand, and then using computer models. After these drawings are tentatively decided upon, the cost of materials must be determined, so as to fit within the allotted budget for the project. The materials are to then be ordered, assembled, broken down, and stored throughout the duration of the competition. We must also design the advertisements and logos for the competition. This is to market and publicize the competition to college level teams. We must also determine the rules for the competition so as to have uniform requirements for all teams. Once these processes are completed, the competition can be finalized and publicized for the public. The contributing parties are Greg Galloway, Robert Mueller, Susan Sawyer, Gloria Murphy, Julia Nething, and Cassandra Liles.

Miasmatic calories and saturating fats: fear of contamination in anorexia.

PubMed

Warin, Megan

2003-03-01

This paper draws on ethnographic material to challenge the taken-for-granted relationship between anorexia and fear of fat. While popular understandings assume anorexia to be an extension of everyday dietary guidelines and a fear of weight gain from foods high in fats and calories, I argue that it is fear of contamination rather than fear of fat per se that is at issue. Through a critique and extension of Mary Douglas' structuralist typology and Julia Kristeva's embodied theory of abjection, I demonstrate that it is the qualities of certain foods, and in particular their amorphous natures, that render them contaminating. Saturating fats and invisible calories are considered dangerous by people with anorexia because they have the ability to move, seep, and infiltrate the body through the interplay of senses. Foods that transgress conceptual and bodily boundaries are thus to be avoided at all costs, for they have the potential to defile and pollute. In light of the low recovery rates for those with anorexia within Australia (and internationally), the findings of this paper have significant implications for the understanding and treatment of this disorder.

A fast and well-conditioned spectral method for singular integral equations

NASA Astrophysics Data System (ADS)

Slevinsky, Richard Mikael; Olver, Sheehan

2017-03-01

We develop a spectral method for solving univariate singular integral equations over unions of intervals by utilizing Chebyshev and ultraspherical polynomials to reformulate the equations as almost-banded infinite-dimensional systems. This is accomplished by utilizing low rank approximations for sparse representations of the bivariate kernels. The resulting system can be solved in O (m2 n) operations using an adaptive QR factorization, where m is the bandwidth and n is the optimal number of unknowns needed to resolve the true solution. The complexity is reduced to O (mn) operations by pre-caching the QR factorization when the same operator is used for multiple right-hand sides. Stability is proved by showing that the resulting linear operator can be diagonally preconditioned to be a compact perturbation of the identity. Applications considered include the Faraday cage, and acoustic scattering for the Helmholtz and gravity Helmholtz equations, including spectrally accurate numerical evaluation of the far- and near-field solution. The JULIA software package SingularIntegralEquations.jl implements our method with a convenient, user-friendly interface.

Noise and soundscape in Rome

NASA Astrophysics Data System (ADS)

Brambilla, Giovanni

2004-05-01

Noise pollution is an old problem in Rome. In 45 B.C. the Lex Julia Municipalis limited carriage traffic in the city center to specific times. Road traffic constitutes the most important and widespread noise source, and several investigations have been conducted since 1972, some aimed at developing a numerical model for predicting the hourly LAeq level. In order to reduce the large impact of this type of noise some measures have been carried out, including surfacing with porous asphalt, erection of noise barriers, limitation in time and spacing of private traffic, etc. However, most of the public complaints deal with noise from equipment operation and recreational activities rather than transportation systems. Moreover, the most famous tourist areas opened to pedestrians only are not as quiet as expected but their sound environment is usually rated more acceptable than noise from other sources at the same level. In compliance with the Italian legislation on noise, the Municipality of Rome issued a noise zoning code for its own territory, and a noise mapping is in progress, pursuant to the requirements of the 2002/49/EC European directive. A Geographical Information System has been also developed to manage all the aspects of noise pollution.

'I don't view myself as a woman politician, I view myself as a politician who's a woman': The discursive management of gender identity in political leadership.

PubMed

Sorrentino, Jasmin; Augoustinos, Martha

2016-09-01

Former Prime Minister Julia Gillard's speech in the Australian parliament on sexism and misogyny received considerable public attention and controversy. However, less attention has been paid to how Gillard attended and oriented to issues related to her status as a woman during the period between her elevation to the position of Prime Minister in June 2010 and the delivery of the misogyny speech in October 2012. Using a discursive psychological approach, this article examines a corpus of interview transcripts in which gender was occasioned both explicitly and implicitly by speakers, thus requiring Gillard to attend to her gender identity. The analysis demonstrates that far from making gender a salient and relevant membership category, Gillard worked strategically to mitigate her gender as merely inconsequential to her role as Prime Minister. These findings are discussed in relation to existing research examining how gender is oriented to, negotiated, and resisted in talk to accomplish social actions, and more specifically what may be at stake for women in leadership positions who explicitly orient to gender as an identity category. © 2016 The British Psychological Society.

The ASA Regional Chapters program

NASA Astrophysics Data System (ADS)

McLaughlin, Elizabeth; Arvelo, Juan

2005-04-01

Are you involved in a Regional Chapter? The Regional Chapters Program certainly embraces the intent of our Society. ``The ASA was founded... to increase and diffuse the knowledge of acoustics and promote its practical applications. Any person... interested in acoustics is eligible for membership.'' The history and the activities of each Chapter are unique. There are currently twenty active chapters uniquely positioned to promote acoustics through outreach and involvement with the public. There have been several new developments in the Regional Chapters Program, the most exciting being the incorporation of Student Chapters! Our first, the Nebraska Student Chapter, was approved at the 75th Meeting of the ASA in NYC. Several more are on their way! Existing Chapters are revitalizing! The Washington DC Chapter has recently found new enthusiasm, re-establishing a robust program. A new student scholarship has been organized thanks to the generosity of Larry and Julia Royster. Another recent enhancement is the expansion of the Regional Chapters Website. There one can find useful materials including an updated Chapter Start-up Kit. Involvement in a chapter is a great way to give back to the ASA, to learn, promote acoustics, to socialize, and to involve new persons in our exciting field!

Reversing Kristeva's first instance of abjection: the formation of self reconsidered.

PubMed

McCabe, Janet L; Holmes, Dave

2011-03-01

Psychoanalyst Julia Kristeva defines the theoretical concept of abjection as an unconscious defence mechanism used to protect the self against threats to one's subjectivity. Kristeva suggests that the first instance of abjection in an individual's life occurs when the child abjects the mother. However, the instance of abjection addressed within this paper is the reverse of this: the abjection of the child, with a disability, by the parent, and more broadly society. Using the contemporary example of prenatal testing, the authors explore how parents of children with disabilities may be influenced in abjecting the child. The implications of abjection of the child are then used to explore normalization, routinization of care and the development of standardized care practices within health-care. Prenatal screening practices and standardized care permeate medical obstetric care and social discourses regarding pregnancy and childbirth, thereby affecting not only healthcare professionals but also parents in their position as consumers of health-care. In a time when the focus of health-care is increasingly placed on disease prevention and broader medical and social discourses glorify normalcy and consistency, the unconscious abjection of those that do not fit within these standards must be identified and addressed. © 2011 Blackwell Publishing Ltd.

Music as Illness; Music as Healing.

PubMed

Pritchard, Maureen

2015-09-01

Throughout the Soviet Union, the arts became tied to ethnicity through the project of Socialist Realism. When, in 1991, the Kyrgyz Republic became independent from the Soviet Union, its national narrative continued to be built upon tropes of Kyrgyz ethnicity. Through their engagement with images of the ethno-national self, the arts provide a great source of beauty. Defining beauty as a representation of the self that is pure whole, and stable, Julia Kristeva asserts that beauty and suffering are part of the same phenomena. Arthur Kleinman argues that suffering is best understood as existing within the triangulated relationship of cultural representation, collective experience, and subjectivity. Music too is part of this triangulated relationship, and therefore, a part of suffering. Drawing upon ten months of ethnographic fieldwork in Kyrgyzstan, this article explores the illness experience of a single Kyrgyz musician. In doing so, it illustrates music's role in self-formation and the development of social, economic, and political ties and the shifts that occur in these during illness. In drawing forth the role of music in the construction of racialized ethnicities, this article demonstrates how the experience of transformative beauty can coexist with turmoil, marginalization, and violence.

Fear, fascination and the sperm donor as 'abjection' in interviews with heterosexual recipients of donor insemination.

PubMed

Burr, Jennifer

2009-07-01

The background to this article is the medical regulation of sperm donation in the UK and the recent policy change so that children born from sperm, eggs or embryos donated after April 2005 have the right to know their donor's identity. I draw upon data from interviews with ten women and seven joint interviews with couples who received donor insemination from an anonymous sperm donor and were the parents of donor insemination children. I explore the symbolic presence of the donor and his potential to disrupt social and physical boundaries using the theoretical conceptions of boundaries and pollution as articulated by Mary Douglas and Julia Kristeva. I present data to argue that the anonymous donor manifests in various figures; the shadowy and ambiguous figure of 'another man'; the intelligent medical student; the donor as a family man, with children of his own who wants to help infertile men father children. In addition participants perceive the donor's physical characteristics, but also see their husband's physical characteristics, in their children. In conclusion I argue that anonymisation preserves features of conventional family life, maintains the idea of exclusivity within the heterosexual relationship and affirms the legal father's insecurity about his infertility.

Statistical Physics on the Eve of the 21st Century: in Honour of J B McGuire on the Occasion of His 65th Birthday

NASA Astrophysics Data System (ADS)

Batchelor, Murray T.; Wille, Luc T.

The Table of Contents for the book is as follows: * Preface * Modelling the Immune System - An Example of the Simulation of Complex Biological Systems * Brief Overview of Quantum Computation * Quantal Information in Statistical Physics * Modeling Economic Randomness: Statistical Mechanics of Market Phenomena * Essentially Singular Solutions of Feigenbaum- Type Functional Equations * Spatiotemporal Chaotic Dynamics in Coupled Map Lattices * Approach to Equilibrium of Chaotic Systems * From Level to Level in Brain and Behavior * Linear and Entropic Transformations of the Hydrophobic Free Energy Sequence Help Characterize a Novel Brain Polyprotein: CART's Protein * Dynamical Systems Response to Pulsed High-Frequency Fields * Bose-Einstein Condensates in the Light of Nonlinear Physics * Markov Superposition Expansion for the Entropy and Correlation Functions in Two and Three Dimensions * Calculation of Wave Center Deflection and Multifractal Analysis of Directed Waves Through the Study of su(1,1)Ferromagnets * Spectral Properties and Phases in Hierarchical Master Equations * Universality of the Distribution Functions of Random Matrix Theory * The Universal Chiral Partition Function for Exclusion Statistics * Continuous Space-Time Symmetries in a Lattice Field Theory * Quelques Cas Limites du Problème à N Corps Unidimensionnel * Integrable Models of Correlated Electrons * On the Riemann Surface of the Three-State Chiral Potts Model * Two Exactly Soluble Lattice Models in Three Dimensions * Competition of Ferromagnetic and Antiferromagnetic Order in the Spin-l/2 XXZ Chain at Finite Temperature * Extended Vertex Operator Algebras and Monomial Bases * Parity and Charge Conjugation Symmetries and S Matrix of the XXZ Chain * An Exactly Solvable Constrained XXZ Chain * Integrable Mixed Vertex Models Ftom the Braid-Monoid Algebra * From Yang-Baxter Equations to Dynamical Zeta Functions for Birational Tlansformations * Hexagonal Lattice Directed Site Animals * Direction in the Star-Triangle Relations * A Self-Avoiding Walk Through Exactly Solved Lattice Models in Statistical Mechanics

Nonlinear Dynamics, Chaotic and Complex Systems

NASA Astrophysics Data System (ADS)

Infeld, E.; Zelazny, R.; Galkowski, A.

2011-04-01

Part I. Dynamic Systems Bifurcation Theory and Chaos: 1. Chaos in random dynamical systems V. M. Gunldach; 2. Controlling chaos using embedded unstable periodic orbits: the problem of optimal periodic orbits B. R. Hunt and E. Ott; 3. Chaotic tracer dynamics in open hydrodynamical flows G. Karolyi, A. Pentek, T. Tel and Z. Toroczkai; 4. Homoclinic chaos L. P. Shilnikov; Part II. Spatially Extended Systems: 5. Hydrodynamics of relativistic probability flows I. Bialynicki-Birula; 6. Waves in ionic reaction-diffusion-migration systems P. Hasal, V. Nevoral, I. Schreiber, H. Sevcikova, D. Snita, and M. Marek; 7. Anomalous scaling in turbulence: a field theoretical approach V. Lvov and I. Procaccia; 8. Abelian sandpile cellular automata M. Markosova; 9. Transport in an incompletely chaotic magnetic field F. Spineanu; Part III. Dynamical Chaos Quantum Physics and Foundations Of Statistical Mechanics: 10. Non-equilibrium statistical mechanics and ergodic theory L. A. Bunimovich; 11. Pseudochaos in statistical physics B. Chirikov; 12. Foundations of non-equilibrium statistical mechanics J. P. Dougherty; 13. Thermomechanical particle simulations W. G. Hoover, H. A. Posch, C. H. Dellago, O. Kum, C. G. Hoover, A. J. De Groot and B. L. Holian; 14. Quantum dynamics on a Markov background and irreversibility B. Pavlov; 15. Time chaos and the laws of nature I. Prigogine and D. J. Driebe; 16. Evolutionary Q and cognitive systems: dynamic entropies and predictability of evolutionary processes W. Ebeling; 17. Spatiotemporal chaos information processing in neural networks H. Szu; 18. Phase transitions and learning in neural networks C. Van den Broeck; 19. Synthesis of chaos A. Vanecek and S. Celikovsky; 20. Computational complexity of continuous problems H. Wozniakowski; Part IV. Complex Systems As An Interface Between Natural Sciences and Environmental Social and Economic Sciences: 21. Stochastic differential geometry in finance studies V. G. Makhankov; Part V. Conference Banquet Speech: Where will the future go? M. J. Feigenbaum.

AI's Philosophical Underpinnings: A Thinking Person's Walk through the Twists and Turns of Artificial Intelligence's Meandering Path

NASA Technical Reports Server (NTRS)

Colombano, Silvano; Norvig, Peter (Technical Monitor)

2000-01-01

Few human endeavors can be viewed both as extremely successful and unsuccessful at the same time. This is typically the case when goals have not been well defined or have been shifting in time. This has certainly been true of Artificial Intelligence (AI). The nature of intelligence has been the object of much thought and speculation throughout the history of philosophy. It is in the nature of philosophy that real headway is sometimes made only when appropriate tools become available. Similarly the computer, coupled with the ability to program (at least in principle) any function, appeared to be the tool that could tackle the notion of intelligence. To suit the tool, the problem of the nature of intelligence was soon sidestepped in favor of this notion: If a probing conversation with a computer could not be distinguished from a conversation with a human, then AI had been achieved. This notion became known as the Turing test, after the mathematician Alan Turing who proposed it in 1950. Conceptually rich and interesting, these early efforts gave rise to a large portion of the field's framework. Key to AI, rather than the 'number crunching' typical of computers until then, was viewed as the ability to manipulate symbols and make logical inferences. To facilitate these tasks, AI languages such as LISP and Prolog were invented and used widely in the field. One idea that emerged and enabled some success with real world problems was the notion that 'most intelligence' really resided in knowledge. A phrase attributed to Feigenbaum, one of the pioneers, was 'knowledge is the power.' With this premise, the problem is shifted from 'how do we solve problems' to 'how do we represent knowledge.' A good knowledge representation scheme could allow one to draw conclusions from given premises. Such schemes took forms such as rules,frames and scripts. It allowed the building of what became known as expert systems or knowledge based systems (KBS).

Comparison of vertical E × B drift velocities and ground-based magnetometer observations of DELTA H in the low latitude under geomagnetically disturbed conditions

NASA Astrophysics Data System (ADS)

Prabhu, M.; Unnikrishnan, K.

2018-04-01

In the present work, we analyzed the daytime vertical E × B drift velocities obtained from Jicamarca Unattended Long-term Ionosphere Atmosphere (JULIA) radar and ΔH component of geomagnetic field measured as the difference between the magnitudes of the horizontal (H) components between two magnetometers deployed at two different locations Jicamarca, and Piura in Peru for 22 geomagnetically disturbed events in which either SC has occurred or Dstmax < -50 nT during the period 2006-2011. The ΔH component of geomagnetic field is measured as the differences in the magnitudes of horizontal H component between magnetometer placed directly on the magnetic equator and one displaced 6-9° away. It will provide a direct measure of the daytime electrojet current, due to the eastward electric field. This will in turn gives the magnitude of vertical E × B drift velocity in the F region. A positive correlation exists between peak values of daytime vertical E × B drift velocity and peak value of ΔH for the three consecutive days of the events. It was observed that 45% of the events have daytime vertical E × B drift velocity peak in the magnitude range 10-20 m/s and 20-30 m/s and 20% have peak ΔH in the magnitude range 50-60 nT and 80-90 nT. It was observed that the time of occurrence of the peak value of both the vertical E × B drift velocity and the ΔH have a maximum (40%) probability in the same time range 11:00-13:00 LT. We also investigated the correlation between E × B drift velocity and Dst index and the correlation between delta H and Dst index. A strong positive correlation is found between E × B drift and Dst index as well as between delta H and Dst Index. Three different techniques of data analysis - linear, polynomial (order 2), and polynomial (order 3) regression analysis were considered. The regression parameters in all the three cases were calculated using the Least Square Method (LSM), using the daytime vertical E × B drift velocity and ΔH. A formula was developed which indicates the relationship between daytime vertical E × B drift velocity and ΔH, for the disturbed periods. The E × B drift velocity was then evaluated using the formulae thus found for the three regression analysis and validated for the 'disturbed periods' of 3 selected events. The E × B drift velocities estimated by the three regression analysis have a fairly good agreement with JULIA radar observed values under different seasons and solar activity conditions. Root Mean Square (RMS) errors calculated for each case suggest that polynomial (order 3) regression analysis provides a better agreement with the observations from among the three.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pasyanos, M; Gok, R; Zor, E

We investigate the crustal and upper mantle structure of eastern Turkey where the Anatolian, Arabian and Eurasian Plates meet and form a complex tectonic structure. The Bitlis suture is a continental collision zone between the Anatolian plateau and the Arabian plate. Broadband data available through the Eastern Turkey Seismic Experiment (ETSE) provided a unique opportunity for studying the high resolution velocity structure. Zor et al. found an average 46 km thick crust in Anatolian plateau using six-layered grid search inversion of the ETSE receiver functions. Receiver functions are sensitive to the velocity contrast of interfaces and the relative travel timemore » of converted and reverberated waves between those interfaces. The interpretation of receiver function alone with many-layered parameterization may result in an apparent depth-velocity tradeoff. In order to improve previous velocity model, we employed the joint inversion method with many layered parameterization of Julia et al. (2000) to the ETSE receiver functions. In this technique, the receiver function and surface-wave observations are combined into a single algebraic equation and each data set is weighted by an estimate of the uncertainty in the observations. We consider azimuthal changes of receiver functions and have stacked them into different groups. We calculated the receiver functions using iterative time-domain deconvolution technique and surface wave group velocity dispersion curves between 10-100 sec. We are making surface wave dispersion measurements at the ETSE stations and have incorporated them into a regional group velocity model. Preliminary results indicate a strong trend in the long period group velocity in the northeast. This indicates slow upper mantle velocities in the region consistent with Pn, Sn and receiver function results. We started with both the 1-D model that is obtained with the 12 tones dam explosion shot data recorded by ETSE network and the existing receiver function inversion results. In fact, we observe that the inversion results are independent at the starting model and converges well to the same final model. We don't observe a significant change at the first order discontinuities of model (e.g. Moho depth), but we obtain better defined depths to low velocity layers.« less

Major hydrological regime change along the semiarid western coast of South America during the early Holocene

NASA Astrophysics Data System (ADS)

Ortega, Cristina; Vargas, Gabriel; Rutllant, José A.; Jackson, Donald; Méndez, César

2012-11-01

Water availability in the semiarid western coast of Chile (30-32°S) is conditioned by high interannual precipitation variability, reflecting the transition between arid subtropical and moist mid-latitude climates in the Southeastern Pacific Ocean. A paleoclimate reconstruction based on the latest Pleistocene-Holocene geological record from the Quebrada Santa Julia archeological site in Chile (31°50'S) and on modern meteorological mechanisms producing alluvial episodes in this region indicates a major change in the rainfall regime shortly after 8600 cal yr BP. This, together with other paleoclimate proxies along the west coast of South America (34°-14°S), suggests La Niña-like conditions 13,000-8600 cal yr BP. Based on sedimentological and geomorphologic evidence, we hypothesized that the absence of heavy rainfall events in northern Chile and the new hydrological regime that prevailed ca. 8600-5700 cal yr BP in north-central Chile resulted from an increase in the large-scale westerly flow over central Chile, as expected in near-neutral ENSO conditions. This atmospheric circulation anomaly is compatible with an equatorward shift of the influence of the Southeast Pacific Subtropical Anticyclone relative to the early Holocene, prior to the onset of modern ENSO variability.

A Tale That Morphology Fails to Tell: A Molecular Phylogeny of Aeolidiidae (Aeolidida, Nudibranchia, Gastropoda)

PubMed Central

Carmona, Leila; Pola, Marta; Gosliner, Terrence M.; Cervera, Juan Lucas

2013-01-01

Aeolidida is one of the largest clades of nudibranchs with at least 560 known species. However, its systematics has not been studied in a comprehensive manner. Phylogenetic analyses of larger clades such as Nudibranchia or Cladobranchia have usually included a poor sample of aeolids. Furthermore, phylogenetic studies at the family or generic level in Aeolidida are a few and far between. The first molecular phylogeny of the aeolid family Aeolidiidae is presented here. This study, the most comprehensive for Aeolidida to date, uses new sequences of two mitochondrial (COI and 16S) genes and one nuclear gene (H3). 251 specimens from members of seven families of Aeolidida, including 39 species of Aeolidiidae were studied. Excluding Pleurolidia juliae, Aeolidiidae is monophyletic. Our results resolve the systematic relationships within the Aeolidiidae at a generic level, requiring changes in the systematics of this family. Spurilla, Anteaeolidiella, Limenandra and Aeolidia are well-supported and monophyletic clades. Aeolidiella stephanieae is transferred to Berghia and Aeolidiopsis ransoni and Spurilla salaamica to Baeolidia, to maintain the monophyletic lineages reflected in this study. The systematics of Cerberilla remains unclear. Some species earlier attributed to Aeolidiella are now grouped in a previously unnamed clade that we designate as Bulbaeolidia gen. nov. PMID:23658794

The Jupyter/IPython architecture: a unified view of computational research, from interactive exploration to communication and publication.

NASA Astrophysics Data System (ADS)

Ragan-Kelley, M.; Perez, F.; Granger, B.; Kluyver, T.; Ivanov, P.; Frederic, J.; Bussonnier, M.

2014-12-01

IPython has provided terminal-based tools for interactive computing in Python since 2001. The notebook document format and multi-process architecture introduced in 2011 have expanded the applicable scope of IPython into teaching, presenting, and sharing computational work, in addition to interactive exploration. The new architecture also allows users to work in any language, with implementations in Python, R, Julia, Haskell, and several other languages. The language agnostic parts of IPython have been renamed to Jupyter, to better capture the notion that a cross-language design can encapsulate commonalities present in computational research regardless of the programming language being used. This architecture offers components like the web-based Notebook interface, that supports rich documents that combine code and computational results with text narratives, mathematics, images, video and any media that a modern browser can display. This interface can be used not only in research, but also for publication and education, as notebooks can be converted to a variety of output formats, including HTML and PDF. Recent developments in the Jupyter project include a multi-user environment for hosting notebooks for a class or research group, a live collaboration notebook via Google Docs, and better support for languages other than Python.

A comparative study of programming languages for next-generation astrodynamics systems

NASA Astrophysics Data System (ADS)

Eichhorn, Helge; Cano, Juan Luis; McLean, Frazer; Anderl, Reiner

2018-03-01

Due to the computationally intensive nature of astrodynamics tasks, astrodynamicists have relied on compiled programming languages such as Fortran for the development of astrodynamics software. Interpreted languages such as Python, on the other hand, offer higher flexibility and development speed thereby increasing the productivity of the programmer. While interpreted languages are generally slower than compiled languages, recent developments such as just-in-time (JIT) compilers or transpilers have been able to close this speed gap significantly. Another important factor for the usefulness of a programming language is its wider ecosystem which consists of the available open-source packages and development tools such as integrated development environments or debuggers. This study compares three compiled languages and three interpreted languages, which were selected based on their popularity within the scientific programming community and technical merit. The three compiled candidate languages are Fortran, C++, and Java. Python, Matlab, and Julia were selected as the interpreted candidate languages. All six languages are assessed and compared to each other based on their features, performance, and ease-of-use through the implementation of idiomatic solutions to classical astrodynamics problems. We show that compiled languages still provide the best performance for astrodynamics applications, but JIT-compiled dynamic languages have reached a competitive level of speed and offer an attractive compromise between numerical performance and programmer productivity.

"How to stop choking to death": Rethinking lesbian separatism as a vibrant political theory and feminist practice.

PubMed

Enszer, Julie R

2016-01-01

In contemporary feminist discourses, lesbian separatism is often mocked. Whether blamed as a central reason for feminism's alleged failure or seen as an unrealistic, utopian vision, lesbian separatism is a maligned social and cultural formation. This article traces the intellectual roots of lesbian feminism from the early 1970s in The Furies and Radicalesbians through the work of Julia Penelope and Sarah Lucia Hoagland in the 1980s and 1990s, then considers four feminist and lesbian organizations that offer innovative engagements with lesbian separatism. Olivia Records operated as a separatist enterprise, producing and distributing womyn's music during the 1970s and 1980s. Two book distributors, Women in Distribution, which operated in the 1970s, and Diaspora Distribution, which operated in the 1980s, offer another approach to lesbian separatism as a form of economic and entrepreneurial engagement. Finally, Sinister Wisdom, a lesbian-feminist literary and arts journal, enacts a number of different forms of lesbian separatism during its forty-year history. These four examples demonstrate economic and cultural investments of lesbian separatism and situate its investments in larger visionary feminist projects. More than a rigid ideology, lesbian separatism operates as a feminist process, a method for living in the world.

Key Components in eHealth Interventions Combining Self-Tracking and Persuasive eCoaching to Promote a Healthier Lifestyle: A Scoping Review.

PubMed

Lentferink, Aniek J; Oldenhuis, Hilbrand Ke; de Groot, Martijn; Polstra, Louis; Velthuijsen, Hugo; van Gemert-Pijnen, Julia Ewc

2017-08-01

The combination of self-tracking and persuasive eCoaching in automated interventions is a new and promising approach for healthy lifestyle management. The aim of this study was to identify key components of self-tracking and persuasive eCoaching in automated healthy lifestyle interventions that contribute to their effectiveness on health outcomes, usability, and adherence. A secondary aim was to identify the way in which these key components should be designed to contribute to improved health outcomes, usability, and adherence. The scoping review methodology proposed by Arskey and O'Malley was applied. Scopus, EMBASE, PsycINFO, and PubMed were searched for publications dated from January 1, 2013 to January 31, 2016 that included (1) self-tracking, (2) persuasive eCoaching, and (3) healthy lifestyle intervention. The search resulted in 32 publications, 17 of which provided results regarding the effect on health outcomes, 27 of which provided results regarding usability, and 13 of which provided results regarding adherence. Among the 32 publications, 27 described an intervention. The most commonly applied persuasive eCoaching components in the described interventions were personalization (n=24), suggestion (n=19), goal-setting (n=17), simulation (n=17), and reminders (n=15). As for self-tracking components, most interventions utilized an accelerometer to measure steps (n=11). Furthermore, the medium through which the user could access the intervention was usually a mobile phone (n=10). The following key components and their specific design seem to influence both health outcomes and usability in a positive way: reduction by setting short-term goals to eventually reach long-term goals, personalization of goals, praise messages, reminders to input self-tracking data into the technology, use of validity-tested devices, integration of self-tracking and persuasive eCoaching, and provision of face-to-face instructions during implementation. In addition, health outcomes or usability were not negatively affected when more effort was requested from participants to input data into the technology. The data extracted from the included publications provided limited ability to identify key components for adherence. However, one key component was identified for both usability and adherence, namely the provision of personalized content. This scoping review provides a first overview of the key components in automated healthy lifestyle interventions combining self-tracking and persuasive eCoaching that can be utilized during the development of such interventions. Future studies should focus on the identification of key components for effects on adherence, as adherence is a prerequisite for an intervention to be effective. ©Aniek J Lentferink, Hilbrand KE Oldenhuis, Martijn de Groot, Louis Polstra, Hugo Velthuijsen, Julia EWC van Gemert-Pijnen. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 01.08.2017.

The Generic Mapping Tools 6: Classic versus Modern Mode

NASA Astrophysics Data System (ADS)

Wessel, P.; Uieda, L.; Luis, J. M. F.; Scharroo, R.; Smith, W. H. F.; Wobbe, F.

2017-12-01

The Generic Mapping Tools (GMT; gmt.soest.hawaii.edu) is a 25-year old, mature open-source software package for the analysis and display of geoscience data (e.g., interpolate, filter, manipulate, project and plot temporal and spatial data). The GMT "toolbox" includes about 80 core and 40 supplemental modules sharing a common set of command options, file structures, and documentation. GMT5, when released in 2013, introduced an application programming interface (API) to allow programmatic access to GMT from other computing environments. Since then, we have released a GMT/MATLAB toolbox, an experimental GMT/Julia package, and will soon introduce a GMT/Python module. In developing these extensions, we wanted to simplify the GMT learning curve but quickly realized the main stumbling blocks to GMT command-line mastery would be ported to the external environments unless we introduced major changes. With thousands of GMT scripts already in use by scientists around the world, we were acutely aware of the need for backwards compatibility. Our solution, to be released as GMT 6, was to add a modern run mode that complements the classic mode offered so far. Modern mode completely eliminates the top three obstacles for new (and not so new) GMT users: (1) The responsibility to properly stack PostScript layers manually (i.e., the -O -K dance), (2) the responsibility of handling output redirection of PostScript (create versus append), and (3) the need to provide commands with repeated information about regions (-R) and projections (-J). Thus, modern mode results in shorter, simpler scripts with fewer pitfalls, without interfering with classic scripts. Our implementation adds five new commands that begin and end a modern session, simplify figure management, automate the conversion of PostScript to more suitable formats, automate region detection, and offer a new automated subplot environment for multi-panel illustrations. Here, we highlight the GMT modern mode and the simplifications it offers, both for command-line use and in external environments. GMT 6 is in beta mode but accessible from our repository. Numerous improvements have been added in addition to modern mode; we expect a formal release in early 2018. Publication partially supported by FCT project UID/GEO/50019/2013 - Instituto D. Luiz.

"Unreliability as a threat to understanding psychopathology: The cautionary tale of attentional bias": Correction to Rodebaugh et al. (2016).

PubMed

2016-10-01

Reports an error in "Unreliability as a threat to understanding psychopathology: The cautionary tale of attentional bias" by Thomas L. Rodebaugh, Rachel B. Scullin, Julia K. Langer, David J. Dixon, Jonathan D. Huppert, Amit Bernstein, Ariel Zvielli and Eric J. Lenze ( Journal of Abnormal Psychology , 2016[Aug], Vol 125[6], 840-851). There was an error in the Author Note concerning the support of the MacBrain Face Stimulus Set. The correct statement is provided. (The following abstract of the original article appeared in record 2016-30117-001.) The use of unreliable measures constitutes a threat to our understanding of psychopathology, because advancement of science using both behavioral and biologically oriented measures can only be certain if such measurements are reliable. Two pillars of the National Institute of Mental Health's portfolio-the Research Domain Criteria (RDoC) initiative for psychopathology and the target engagement initiative in clinical trials-cannot succeed without measures that possess the high reliability necessary for tests involving mediation and selection based on individual differences. We focus on the historical lack of reliability of attentional bias measures as an illustration of how reliability can pose a threat to our understanding. Our own data replicate previous findings of poor reliability for traditionally used scores, which suggests a serious problem with the ability to test theories regarding attentional bias. This lack of reliability may also suggest problems with the assumption (in both theory and the formula for the scores) that attentional bias is consistent and stable across time. In contrast, measures accounting for attention as a dynamic process in time show good reliability in our data. The field is sorely in need of research reporting findings and reliability for attentional bias scores using multiple methods, including those focusing on dynamic processes over time. We urge researchers to test and report reliability of all measures, considering findings of low reliability not just as a nuisance but as an opportunity to modify and improve upon the underlying theory. Full assessment of reliability of measures will maximize the possibility that RDoC (and psychological science more generally) will succeed. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

The Density-wave Theory and Spiral Structures by Looking at Spiral Arms through a Multi-wavelength StudyHamed Pour-Imani1,2, Daniel Kennefick1,2, Julia Kennefick1,2, Mohamed Shameer Abdeen1,2, Eric Monson1,2, Douglas W. Shields1,2, B. L. Davis31Department of Physics, University of Arkansas, Fayetteville, AR 72701, USA2Arkansas Center for Space & Planetary Sciences, Univ. of Arkans

NASA Astrophysics Data System (ADS)

Pour-Imani, Hamed; Kennefick, Daniel; Kennefick, Julia; Shameer Abdeen, Mohammad; Monson, Erick; Shields, Douglas William; Davis, Benjamin L.

2018-01-01

The density-wave theory of spiral structure, though first proposed as long ago as the mid-1960s by C.C. Lin and F. Shu, continues to be challenged by rival theories, such as the manifold theory. One test between these theories which has been proposed is that the pitch angle of spiral arms for galaxies should vary with the wavelength of the image in the density-wave theory, but not in the manifold theory. The reason is that stars are born in the density wave but move out of it as they age. In this study, we combined large sample size with a wide range of wavelengths to investigate this issue. For each galaxy, we used wavelength FUV151nm, U-band, H-alpha, optical wavelength B-band and infrared 3.6 and 8.0μm. We measured the pitch angle with the 2DFFT and Spirality codes (Davis et al. 2012; Shields et al. 2015). We find that the B-band and 3.6μm images have smaller pitch angles than the infrared 8.0μm image in all cases, in agreement with the prediction of the density-wave theory. We also find that the pitch angle at FUV and H-alpha are close to the measurements made at 8.0μm. The Far-ultraviolet wavelength at 151nm shows very young, very bright UV stars still in the star-forming region (they are so bright as to be visible there and so short-lived that they never move out of it). We find that for both sets of measurements (2dFFT and Spirality) the 8.0μm, H-alpha and ultraviolet images agree in their pitch angle measurements, suggesting that they are, in fact, sensitive to the same region. By contrast, the 3.6μm and B-band images are uniformly tighter in pitch angle measurements than these wavelengths, suggesting that the density-wave picture is correct.

App-Supported Promotion of Child Growth and Development by Community Health Workers in Kenya: Feasibility and Acceptability Study.

PubMed

van Heerden, Alastair; Sen, Debjeet; Desmond, Chris; Louw, Julia; Richter, Linda

2017-12-05

Early childhood is a critical phase of development. In low resource settings, monitoring this stage of development and providing appropriate and timely feedback is a challenge. Community-based service providers play a key role in promoting early childhood development in areas where government services are weak. These community-based service providers are also tasked with the collection of monitoring and evaluation data for donors and local government. Usually, collection of these data aims to provide accountability, learning, and correction leading to improvement. However, such data is rarely used beyond the accountability stage. The purpose of this study was to test the feasibility and acceptability of the Information for Action (IFA) mobile phone app. The IFA app was designed for use by community health volunteers (CHVs), and repackages routinely collected data about children into useful, offline decision support for caregivers and program managers. The IFA app was tested with a convenience sample of 10 CHVs in West Katweng'a, a sublocation of Rarieda subcounty in western Kenya. CHVs used the IFA app for 5 months as part of their regular home visits to households containing children aged 0 to 5 years, after which a qualitative assessment of the app was conducted. A total of 16 caregivers who received services from the CHVs were randomly selected to participate in 1 of 2 focus group discussions about their experience. The app was reported to help facilitate interactive dialog between CHVs and caregivers, leading to improved quality of home visits. Caregivers described the app as shifting the relationship from feeling harassed by CHVs to experiencing genuine interest from CHVs. CHVs reported feasibility challenges primarily related to infrastructure. The limited battery life of mobile phones combined with the lack of readily available electricity made it difficult to keep the phones charged. CHVs reported initial anxiety as first-time mobile phones users, including concerns about using the IFA app. With time, increased levels of confidence were seen. Acceptability was high with both CHVs and caregivers, who reported an improvement in their client-provider relationship. A number of feasibility challenges were experienced. ©Alastair van Heerden, Debjeet Sen, Chris Desmond, Julia Louw, Linda Richter. Originally published in JMIR Mhealth and Uhealth (http://mhealth.jmir.org), 05.12.2017.

Bi-Level Decision Making for Supporting Energy and Water Nexus

NASA Astrophysics Data System (ADS)

Zhang, X.; Vesselinov, V. V.

2016-12-01

The inseparable relationship between energy production and water resources has led to the emerging energy-water nexus concept, which provides a means for integrated management and decision making of these two critical resources. However, the energy-water nexus frequently involves decision makers with different and competing management objectives. Furthermore, there is a challenge that decision makers and stakeholders might be making decisions sequentially from a higher level to a lower level, instead of at the same decision level, whereby the objective of a decision maker at a higher level should be satisfied first. In this study, a bi-level decision model is advanced to handle such decision-making situations for managing the energy-water nexus. The work represents a unique contribution to developing an integrated decision-support framework/tool to quantify and analyze the tradeoffs between the two-level energy-water nexus decision makers. Here, plans for electricity generation, fuel supply, water supply, capacity expansion of the power plants and environmental impacts are optimized to provide effective decision support. The developed decision-support framework is implemented in Julia (a high-level, high-performance dynamic programming language for technical computing) and is a part of the MADS (Model Analyses & Decision Support) framework (http://mads.lanl.gov). To demonstrate the capabilities of the developed methodology, a series of analyses are performed for synthetic problems consistent with actual real-world energy-water nexus management problems.

IPython: components for interactive and parallel computing across disciplines. (Invited)

NASA Astrophysics Data System (ADS)

Perez, F.; Bussonnier, M.; Frederic, J. D.; Froehle, B. M.; Granger, B. E.; Ivanov, P.; Kluyver, T.; Patterson, E.; Ragan-Kelley, B.; Sailer, Z.

2013-12-01

Scientific computing is an inherently exploratory activity that requires constantly cycling between code, data and results, each time adjusting the computations as new insights and questions arise. To support such a workflow, good interactive environments are critical. The IPython project (http://ipython.org) provides a rich architecture for interactive computing with: 1. Terminal-based and graphical interactive consoles. 2. A web-based Notebook system with support for code, text, mathematical expressions, inline plots and other rich media. 3. Easy to use, high performance tools for parallel computing. Despite its roots in Python, the IPython architecture is designed in a language-agnostic way to facilitate interactive computing in any language. This allows users to mix Python with Julia, R, Octave, Ruby, Perl, Bash and more, as well as to develop native clients in other languages that reuse the IPython clients. In this talk, I will show how IPython supports all stages in the lifecycle of a scientific idea: 1. Individual exploration. 2. Collaborative development. 3. Production runs with parallel resources. 4. Publication. 5. Education. In particular, the IPython Notebook provides an environment for "literate computing" with a tight integration of narrative and computation (including parallel computing). These Notebooks are stored in a JSON-based document format that provides an "executable paper": notebooks can be version controlled, exported to HTML or PDF for publication, and used for teaching.

Variance Component Selection With Applications to Microbiome Taxonomic Data.

PubMed

Zhai, Jing; Kim, Juhyun; Knox, Kenneth S; Twigg, Homer L; Zhou, Hua; Zhou, Jin J

2018-01-01

High-throughput sequencing technology has enabled population-based studies of the role of the human microbiome in disease etiology and exposure response. Microbiome data are summarized as counts or composition of the bacterial taxa at different taxonomic levels. An important problem is to identify the bacterial taxa that are associated with a response. One method is to test the association of specific taxon with phenotypes in a linear mixed effect model, which incorporates phylogenetic information among bacterial communities. Another type of approaches consider all taxa in a joint model and achieves selection via penalization method, which ignores phylogenetic information. In this paper, we consider regression analysis by treating bacterial taxa at different level as multiple random effects. For each taxon, a kernel matrix is calculated based on distance measures in the phylogenetic tree and acts as one variance component in the joint model. Then taxonomic selection is achieved by the lasso (least absolute shrinkage and selection operator) penalty on variance components. Our method integrates biological information into the variable selection problem and greatly improves selection accuracies. Simulation studies demonstrate the superiority of our methods versus existing methods, for example, group-lasso. Finally, we apply our method to a longitudinal microbiome study of Human Immunodeficiency Virus (HIV) infected patients. We implement our method using the high performance computing language Julia. Software and detailed documentation are freely available at https://github.com/JingZhai63/VCselection.

Breaking generalized covariance, classical renormalization, and boundary conditions from superpotentials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Livshits, Gideon I., E-mail: livshits.gideon@mail.huji.ac.il

2014-02-15

Superpotentials offer a direct means of calculating conserved charges associated with the asymptotic symmetries of space-time. Yet superpotentials have been plagued with inconsistencies, resulting in nonphysical or incongruent values for the mass, angular momentum, and energy loss due to radiation. The approach of Regge and Teitelboim, aimed at a clear Hamiltonian formulation with a boundary, and its extension to the Lagrangian formulation by Julia and Silva have resolved these issues, and have resulted in a consistent, well-defined and unique variational equation for the superpotential, thereby placing it on a firm footing. A hallmark solution of this equation is the KBLmore » superpotential obtained from the first-order Lovelock Lagrangian. Nevertheless, here we show that these formulations are still insufficient for Lovelock Lagrangians of higher orders. We present a paradox, whereby the choice of fields affects the superpotential for equivalent on-shell dynamics. We offer two solutions to this paradox: either the original Lagrangian must be effectively renormalized, or that boundary conditions must be imposed, so that space-time be asymptotically maximally symmetric. Non-metricity is central to this paradox, and we show how quadratic non-metricity in the bulk of space-time contributes to the conserved charges on the boundary, where it vanishes identically. This is a realization of the gravitational Higgs mechanism, proposed by Percacci, where the non-metricity is the analogue of the Goldstone boson.« less

Synthesis and Magnetic, Thermal, and Electrical Measurements on Complex non-Cuprate Superconductors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Henry, Laurence L

2006-02-27

The project investigated superconductivity in non-cuprate materials with critical temperatures, T{sub c}, in excess of 20 K in order to understand the thermodynamics of several of these materials. The project is a cooperative effort between investigators at Southern University (SU), Louisiana State University (LSU), and Los Alamos National Laboratory (LANL). It involved synthesis of high quality samples, and subsequent detailed magnetic, thermal and electrical measurements on them. The project provided a PhD Thesis research experience and training for a graduate student, Ms. Robin Macaluso. High quality, single crystal samples were synthesized by Ms. Macaluso under the direction of one ofmore » the CO-PIS, John Sarao, during the summer while she was a visitor at LANL being supported by this grant. On these samples magnetic measurements were performed at SU, thermal and electrical measurements were made in the LSU Physics and Astronomy Department. The crystallographic properties were determined in the LSU Chemistry Department by Ms. Macaluso under the direction of her dissertation advisor, Dr. Julia Chan. Additional high field magnetic measurements on other samples were performed at the National High Magnetic Field Laboratory (NHMFL) both in Tallahassee and at LANL. These measurements involved another graduate student, Umit Alver, who used some of the measurements as part of his PhD dissertation in Physics at LSU.« less

Nursing empire: travel letters from Africa and the Caribbean

PubMed Central

Howell, Jessica

2012-01-01

This essay analyses colonial nurses’ travel letters, written from West Africa and the Caribbean between the turn of the century and 1920, in order to better understand the role of nurses in forming satellite versions of home. Though their primary function was to ‘nurse empire’ by helping to repair and maintain the bodies needed for imperial labour, nurses also contributed to written discourses supporting Britain's economic interests and political goals. Through careful consideration of primary archival material, this essay analyses the rhetorical modes that may have helped nurses gain professional and personal authority abroad. It considers nurses as moving within several kinds of imperial networks – geographical, institutional and discursive – and traces the shifts in their written self-representation according to these different contexts. In order to reform nursing, in the mid-nineteenth century Florence Nightingale defined the ‘New Nurse's’ ideal personality as well as her duties. Ever since, the nurse's ‘character’ has often been essentialised in literature and culture. As Julia Hallam observes in Nursing the Image (2000), the nurse is commonly portrayed as ministering angel, potential seductress, battleaxe or doctor's helpmate. The goal of this essay is to resist simplifying nurses’ cultural significance, motivations or experiences by studying the multiple influences to which colonial nurses were subject and the shifting registers in their writing. PMID:24764748

Grain-size-yield stress relationship: Analysis and computation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meyers, M.A.; Benson, D.J.; Fu, H.H.

1999-07-01

The seminal contributions of Julia Weertman to the understanding of the mechanical properties of nanocrystalline materials will be briefly outlined. A constitutive equation predicting the effect of grain size on the yield stress of metals, based on the model proposed by M.A. Meyers and E. Ashworth, is discussed and extended to the nanocrystalline regime. At large grain sizes, it has the Hall-Petch form, and in the nanocrystalline domain the slope gradually decreases until it asymptotically approaches the flow stress of the grain boundaries. The material is envisaged as a composite, comprised of the grain interior, with flow stress {sigma}{sub fB},more » and grain boundary work-hardened layer, with flow stress {sigma}{sub fGB}. Three principal factors contribute to the grain-boundary hardening: (1) the grain boundaries act as barriers to plastic flow; (2) the grain boundaries act as dislocation sources; and (3) elastic anisotropy causes additional stresses in grain-boundary surroundings. The predictions of this model are compared with experimental measurements over the mono, micro, and nanocrystalline domains. Computational predictions are made of plastic flow as a function of grain size incorporating elastic and plastic anisotropy as well as differences of dislocation accumulation rate in grain boundary regions and grain interiors. This is the first plasticity calculation that accounts for grain size effects in a physically-based manner. 58 refs., 7 figs., 1 tab.« less

A haphazard reading of McHugh and Barlow (2010).

PubMed

McHugh, R Kathryn; Barlow, David H

2010-12-01

Replies to comments on Do haphazard reviews provide sound directions for dissemination efforts? (see record 2010-24768-012) by Eileen Gambrill and Julia H. Littell on the current authors' article The dissemination and implementation of evidence-based psychological treatments: A review of current efforts (see record 2010-02208-010) by Kathryn R. McHugh and David H. Barlow. In their commentary, Gambrill and Littell (2010, this issue) suggested that we provided misleading guidance on the selection of treatments for dissemination in our recent article (McHugh & Barlow, February- March 2010) on the dissemination and implementation of evidence-based treatments. These authors misread our article as an affirmation of the evidence base of the treatments involved in the dissemination and implementation efforts we described. In fact, we explicitly disclaimed in the third paragraph that "we do not revisit controversies surrounding the identification or appropriateness of [evidence-based psychological treatments] . . . rather, we focus on the status and adequacy of [dissemination and implementation] efforts currently under way (McHugh & Barlow, 2010, p. 73). Thus, our review was not intended as a guideline for which treatments to disseminate, nor was it a thorough review of the evidence base for the treatments included in the efforts we reviewed. We chose several programs for illustrative purposes as representative efforts from three general domains: national, state, and investigator initiated. PsycINFO Database Record (c) 2010 APA, all rights reserved.

Detection of kinetic change points in piece-wise linear single molecule motion

NASA Astrophysics Data System (ADS)

Hill, Flynn R.; van Oijen, Antoine M.; Duderstadt, Karl E.

2018-03-01

Single-molecule approaches present a powerful way to obtain detailed kinetic information at the molecular level. However, the identification of small rate changes is often hindered by the considerable noise present in such single-molecule kinetic data. We present a general method to detect such kinetic change points in trajectories of motion of processive single molecules having Gaussian noise, with a minimum number of parameters and without the need of an assumed kinetic model beyond piece-wise linearity of motion. Kinetic change points are detected using a likelihood ratio test in which the probability of no change is compared to the probability of a change occurring, given the experimental noise. A predetermined confidence interval minimizes the occurrence of false detections. Applying the method recursively to all sub-regions of a single molecule trajectory ensures that all kinetic change points are located. The algorithm presented allows rigorous and quantitative determination of kinetic change points in noisy single molecule observations without the need for filtering or binning, which reduce temporal resolution and obscure dynamics. The statistical framework for the approach and implementation details are discussed. The detection power of the algorithm is assessed using simulations with both single kinetic changes and multiple kinetic changes that typically arise in observations of single-molecule DNA-replication reactions. Implementations of the algorithm are provided in ImageJ plugin format written in Java and in the Julia language for numeric computing, with accompanying Jupyter Notebooks to allow reproduction of the analysis presented here.

Superbranes, D = 11 CJS Supergravity and Enlarged Superspace Coordinates/Fields Correspondence

DOE Office of Scientific and Technical Information (OSTI.GOV)

Azcarraga, J.A. de; IFIC - CSIC-UVEG, Facultad de Fisica, 46100-Burjassot, Valencia

2005-04-25

We discuss the role of enlarged superspaces in two seemingly different contexts, the structure of the p-brane actions and that of the Cremmer-Julia-Scherk eleven-dimensional supergravity. Both provide examples of a common principle: the existence of an enlarged superspaces coordinates/fields correspondence by which all the (worldvolume or spacetime) fields of the theory are associated to coordinates of enlarged superspaces. In the context of p-branes, enlarged superspaces may be used to construct manifestly supersymmetry-invariant Wess-Zumino terms and as a way of expressing the Born-Infeld worldvolume fields of D-branes and the worldvolume M5-brane two-form in terms of fields associated to the coordinates ofmore » these enlarged superspaces. This is tantamount to saying that the Born-Infeld fields have a superspace origin, as do the other worldvolume fields, and that they have a composite structure. In D=11 supergravity theory enlarged superspaces arise when its underlying gauge structure is investigated and, as a result, the composite nature of the A3 field is revealed: there is a full one-parametric family of enlarged superspace groups that solve the problem of expressing A3 in terms of spacetime fields associated to their coordinates. The corresponding enlarged supersymmetry algebras turn out to be deformations of an expansion of the osp(1 vertical bar 32) algebra. The unifying mathematical structure underlying all these facts is the cohomology of the supersymmetry algebras involved.« less

Large-scale inverse model analyses employing fast randomized data reduction

NASA Astrophysics Data System (ADS)

Lin, Youzuo; Le, Ellen B.; O'Malley, Daniel; Vesselinov, Velimir V.; Bui-Thanh, Tan

2017-08-01

When the number of observations is large, it is computationally challenging to apply classical inverse modeling techniques. We have developed a new computationally efficient technique for solving inverse problems with a large number of observations (e.g., on the order of 107 or greater). Our method, which we call the randomized geostatistical approach (RGA), is built upon the principal component geostatistical approach (PCGA). We employ a data reduction technique combined with the PCGA to improve the computational efficiency and reduce the memory usage. Specifically, we employ a randomized numerical linear algebra technique based on a so-called "sketching" matrix to effectively reduce the dimension of the observations without losing the information content needed for the inverse analysis. In this way, the computational and memory costs for RGA scale with the information content rather than the size of the calibration data. Our algorithm is coded in Julia and implemented in the MADS open-source high-performance computational framework (http://mads.lanl.gov). We apply our new inverse modeling method to invert for a synthetic transmissivity field. Compared to a standard geostatistical approach (GA), our method is more efficient when the number of observations is large. Most importantly, our method is capable of solving larger inverse problems than the standard GA and PCGA approaches. Therefore, our new model inversion method is a powerful tool for solving large-scale inverse problems. The method can be applied in any field and is not limited to hydrogeological applications such as the characterization of aquifer heterogeneity.

Scoping Review of Dance for Adults With Fibromyalgia: What Do We Know About It?

PubMed

Bidonde, Julia; Boden, Catherine; Kim, Soo; Busch, Angela J; Goes, Suelen M; Knight, Emily

2018-05-10

Fibromyalgia is a chronic disorder characterized by widespread muscular tenderness, pain, fatigue, and cognitive difficulties. Nonpharmacological treatment options, such as physical activity, are important for people with fibromyalgia. There are strong recommendations to support engagement in physical activity for symptom management among adults with fibromyalgia. Dance is a mode of physical activity that may allow individuals with fibromyalgia to improve their physical function, health, and well-being. Dance has the potential to promote improved pain processing while simultaneously providing the health and social benefits of engaging in physical activity that contributes to symptom management and overall function rehabilitation. However, we are unaware of current evidence on dance as a nonpharmacological/physical activity intervention for adults with fibromyalgia. The aims of this study were to understand how dance is used therapeutically by individuals with fibromyalgia; to examine the extent, range and nature of research activity in the area; and to determine the value of undertaking a systematic review of interventions. We used and adapted the Arksey and O'Malley scoping framework. The search strategy involved a comprehensive search of main health and electronic social databases, trial registries and grey literature without language limits. Pairs of reviewers independently screened and extracted data and evaluated the methodological quality of randomized control trials. Twenty-one unique records for 13 studies met inclusion criteria; the studies included mostly middle-aged women. Types of dance included were aerobic dance, belly dance, dance movement therapy, biodanza and Zumba. Intervention parameters were different among studies. Frequency varied between one to three times a week; all were done in small group settings. Studies evaluated a variety of outcomes in the symptoms, wellness, psychosocial, physical functioning, balance and fitness categories; no studies evaluated the safety or adverse events systematically which is a major weakness of the literature. There are few studies in the field of dance and fibromyalgia, suggesting research is in its infancy but slowly growing. They are of European and South American origin, focusing on female participants and a limited number of dance modes. Because the body of literature is small, of low quality and highly heterogeneous, we concluded that a systematic review of interventions on dance is not warranted at this time. ©Julia Bidonde, Catherine Boden, Soo Kim, Angela J Busch, Suelen M Goes, Emily Knight. Originally published in JMIR Rehabilitation and Assistive Technology (http://rehab.jmir.org), 10.05.2018.

List of Organizing Committees and Conference Programme

NASA Astrophysics Data System (ADS)

2012-03-01

Organizers Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research Horia Hulubei National Institute of Physics and Nuclear Engineering - IFIN HH Romanian Neutron Scattering Society Sponsors Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research Horia Hulubei National Institute of Physics and Nuclear Engineering - IFIN HH Comenius University in Bratislava, Slovakia Institute of Macromolecular Chemistry AS CR, Czech Republic Programme Committee Valentin Gordely (chairman)Joint Institute for Nuclear Research, Russia Heinrich StuhrmannGermany Jose TeixeiraLaboratoire Leon Brillouin, France Pavel ApelJoint Institute for Nuclear Research, Russia Pavol BalgavyComenius University in Bratislava, Slovakia Alexander BelushkinJoint Institute for Nuclear Research, Russia Georg BueldtInstitute of Structural Biology and Biophysics (ISB), Germany Leonid BulavinTaras Shevchenko National University of Kyiv, Ukraine Emil BurzoBabes-Bolyai University, Romania Vadim CherezovThe Scripps Research Institute, Department of Molecular Biology, USA Ion IonitaRomanian Society of Neutron Scattering, Romania Alexei KhokhlovMoscow State University, Russia Aziz MuzafarovInstitute of Synthetic Polymeric Materials, Russian Academy of Sciences, Russia Alexander OzerinInstitute of Synthetic Polymeric Materials, Russian Academy of Sciences, Russia Gerard PepyResearch Institute for Solid State Physics and Optics, Hungary Josef PlestilInstitute of Macromolecular Chemistry CAS, Czech Republic Aurel RadulescuJuelich Centre for Neutron Science JCNS, Germany Maria BalasoiuJoint Institute for Nuclear Research, Russia Alexander KuklinJoint Institute for Nuclear Research, Russia Local Organizing Committee Alexander Kuklin - Chairman Maria Balasoiu - Co-chairman Tatiana Murugova - Secretary Natalia Malysheva Natalia Dokalenko Julia Gorshkova Andrey Rogachev Oleksandr Ivankov Dmitry Soloviev Lilia Anghel Erhan Raul The PDF also contains the Conference Programme.

A rapid local singularity analysis algorithm with applications

NASA Astrophysics Data System (ADS)

Chen, Zhijun; Cheng, Qiuming; Agterberg, Frits

2015-04-01

The local singularity model developed by Cheng is fast gaining popularity in characterizing mineralization and detecting anomalies of geochemical, geophysical and remote sensing data. However in one of the conventional algorithms involving the moving average values with different scales is time-consuming especially while analyzing a large dataset. Summed area table (SAT), also called as integral image, is a fast algorithm used within the Viola-Jones object detection framework in computer vision area. Historically, the principle of SAT is well-known in the study of multi-dimensional probability distribution functions, namely in computing 2D (or ND) probabilities (area under the probability distribution) from the respective cumulative distribution functions. We introduce SAT and it's variation Rotated Summed Area Table in the isotropic, anisotropic or directional local singularity mapping in this study. Once computed using SAT, any one of the rectangular sum can be computed at any scale or location in constant time. The area for any rectangular region in the image can be computed by using only 4 array accesses in constant time independently of the size of the region; effectively reducing the time complexity from O(n) to O(1). New programs using Python, Julia, matlab and C++ are implemented respectively to satisfy different applications, especially to the big data analysis. Several large geochemical and remote sensing datasets are tested. A wide variety of scale changes (linear spacing or log spacing) for non-iterative or iterative approach are adopted to calculate the singularity index values and compare the results. The results indicate that the local singularity analysis with SAT is more robust and superior to traditional approach in identifying anomalies.

Toward a theory of high performance.

PubMed

Kirby, Julia

2005-01-01

What does it mean to be a high-performance company? The process of measuring relative performance across industries and eras, declaring top performers, and finding the common drivers of their success is such a difficult one that it might seem a fool's errand to attempt. In fact, no one did for the first thousand or so years of business history. The question didn't even occur to many scholars until Tom Peters and Bob Waterman released In Search of Excellence in 1982. Twenty-three years later, we've witnessed several more attempts--and, just maybe, we're getting closer to answers. In this reported piece, HBR senior editor Julia Kirby explores why it's so difficult to study high performance and how various research efforts--including those from John Kotter and Jim Heskett; Jim Collins and Jerry Porras; Bill Joyce, Nitin Nohria, and Bruce Roberson; and several others outlined in a summary chart-have attacked the problem. The challenge starts with deciding which companies to study closely. Are the stars the ones with the highest market caps, the ones with the greatest sales growth, or simply the ones that remain standing at the end of the game? (And when's the end of the game?) Each major study differs in how it defines success, which companies it therefore declares to be worthy of emulation, and the patterns of activity and attitude it finds in common among them. Yet, Kirby concludes, as each study's method incrementally solves problems others have faced, we are progressing toward a consensus theory of high performance.

Mobile Phone Interventions for Sleep Disorders and Sleep Quality: Systematic Review.

PubMed

Shin, Jong Cheol; Kim, Julia; Grigsby-Toussaint, Diana

2017-09-07

Although mobile health technologies have been developed for interventions to improve sleep disorders and sleep quality, evidence of their effectiveness remains limited. A systematic literature review was performed to determine the effectiveness of mobile technology interventions for improving sleep disorders and sleep quality. Four electronic databases (EBSCOhost, PubMed/Medline, Scopus, and Web of Science) were searched for articles on mobile technology and sleep interventions published between January 1983 and December 2016. Studies were eligible for inclusion if they met the following criteria: (1) written in English, (2) adequate details on study design, (3) focus on sleep intervention research, (4) sleep index measurement outcome provided, and (5) publication in peer-reviewed journals. An initial sample of 2679 English-language papers were retrieved from five electronic databases. After screening and review, 16 eligible studies were evaluated to examine the impact of mobile phone interventions on sleep disorders and sleep quality. These included one case study, three pre-post studies, and 12 randomized controlled trials. The studies were categorized as (1) conventional mobile phone support and (2) utilizing mobile phone apps. Based on the results of sleep outcome measurements, 88% (14/16) studies showed that mobile phone interventions have the capability to attenuate sleep disorders and to enhance sleep quality, regardless of intervention type. In addition, mobile phone intervention methods (either alternatively or as an auxiliary) provide better sleep solutions in comparison with other recognized treatments (eg, cognitive behavioral therapy for insomnia). We found evidence to support the use of mobile phone interventions to address sleep disorders and to improve sleep quality. Our findings suggest that mobile phone technologies can be effective for future sleep intervention research. ©Jong Cheol Shin, Julia Kim, Diana Grigsby-Toussaint. Originally published in JMIR Mhealth and Uhealth (http://mhealth.jmir.org), 07.09.2017.

A Peer-Led Electronic Mental Health Recovery App in an Adult Mental Health Service: Study Protocol for a Pilot Trial.

PubMed

Gulliver, Amelia; Banfield, Michelle; Reynolds, Julia; Miller, Sarah; Galati, Connie; Morse, Alyssa R

2017-12-07

There is growing demand for peer workers (people who use their own lived experience to support others in their recovery) to work alongside consumers to improve outcomes and recovery. Augmenting the workforce with peer workers has strong capacity to enhance mental health and recovery outcomes and make a positive contribution to the workforce within mental health systems and to the peer workers themselves. Technology-based applications are highly engaging and desirable methods of service delivery. This project is an exploratory proof-of-concept study, which aims to determine if a peer worker-led electronic mental (e-mental) health recovery program is a feasible, acceptable, and effective adjunct to usual treatment for people with moderate to severe mental illness. The study design comprises a recovery app intervention delivered by a peer worker to individual consumers at an adult mental health service. Evaluation measures will be conducted at post-intervention. To further inform the acceptability and feasibility of the model, consumers will be invited to participate in a focus group to discuss the program. The peer worker, peer supervisor, and key staff at the mental health service will also be individually interviewed to further evaluate the feasibility of the program within the health service and further inform its future development. The program will be delivered over a period of approximately 4 months, commencing June 2017. If the peer worker-led recovery app is found to be feasible, acceptable, and effective, it could be used to improve recovery in mental health service consumers. ©Amelia Gulliver, Michelle Banfield, Julia Reynolds, Sarah Miller, Connie Galati, Alyssa R Morse. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 07.12.2017.

Dental Blogs, Podcasts, and Associated Social Media: Descriptive Mapping and Analysis.

PubMed

Melkers, Julia; Hicks, Diana; Rosenblum, Simone; Isett, Kimberley R; Elliott, Jacqueline

2017-07-26

Studies of social media in both medicine and dentistry have largely focused on the value of social media for marketing to and communicating with patients and for clinical education. There is limited evidence of how dental clinicians contribute to and use social media to disseminate and access information relevant to clinical care. The purpose of this study was to inventory and assess the entry, growth, sources, and content of clinically relevant social media in dentistry. We developed an inventory of blogs, podcasts, videos, and associated social media disseminating clinical information to dentists. We assessed hosts' media activity in terms of their combinations of modalities, entry and exit dates, frequency of posting, types of content posted, and size of audience. Our study showed that clinically relevant information is posted by dentists and hygienists on social media. Clinically relevant information was provided in 89 blogs and podcasts, and topic analysis showed motives for blogging by host type: 55% (49 hosts) were practicing dentists or hygienists, followed by consultants (27 hosts, 30%), media including publishers and discussion board hosts (8 hosts, 9%), and professional organizations and corporations. We demonstrated the participation of and potential for practicing dentists and hygienists to use social media to share clinical and other information with practicing colleagues. There is a clear audience for these social media sites, suggesting a changing mode of information diffusion in dentistry. This study was a first effort to fill the gap in understanding the nature and potential role of social media in clinical dentistry. ©Julia Melkers, Diana Hicks, Simone Rosenblum, Kimberley R Isett, Jacqueline Elliott. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 26.07.2017.

Semi-supervised Machine Learning for Analysis of Hydrogeochemical Data and Models

NASA Astrophysics Data System (ADS)

Vesselinov, Velimir; O'Malley, Daniel; Alexandrov, Boian; Moore, Bryan

2017-04-01

Data- and model-based analyses such as uncertainty quantification, sensitivity analysis, and decision support using complex physics models with numerous model parameters and typically require a huge number of model evaluations (on order of 10^6). Furthermore, model simulations of complex physics may require substantial computational time. For example, accounting for simultaneously occurring physical processes such as fluid flow and biogeochemical reactions in heterogeneous porous medium may require several hours of wall-clock computational time. To address these issues, we have developed a novel methodology for semi-supervised machine learning based on Non-negative Matrix Factorization (NMF) coupled with customized k-means clustering. The algorithm allows for automated, robust Blind Source Separation (BSS) of groundwater types (contamination sources) based on model-free analyses of observed hydrogeochemical data. We have also developed reduced order modeling tools, which coupling support vector regression (SVR), genetic algorithms (GA) and artificial and convolutional neural network (ANN/CNN). SVR is applied to predict the model behavior within prior uncertainty ranges associated with the model parameters. ANN and CNN procedures are applied to upscale heterogeneity of the porous medium. In the upscaling process, fine-scale high-resolution models of heterogeneity are applied to inform coarse-resolution models which have improved computational efficiency while capturing the impact of fine-scale effects at the course scale of interest. These techniques are tested independently on a series of synthetic problems. We also present a decision analysis related to contaminant remediation where the developed reduced order models are applied to reproduce groundwater flow and contaminant transport in a synthetic heterogeneous aquifer. The tools are coded in Julia and are a part of the MADS high-performance computational framework (https://github.com/madsjulia/Mads.jl).

Cultural crossings of care: An appeal to the medical humanities

PubMed Central

Kristeva, Julia; Moro, Marie Rose; Ødemark, John; Engebretsen, Eivind

2018-01-01

Modern medicine is confronted with cultural crossings in various forms. In facing these challenges, it is not enough to simply increase our insight into the cultural dimensions of health and well-being. We must, more radically, question the conventional distinction between the ‘objectivity of science’ and the ‘subjectivity of culture’. This obligation creates an urgent call for the medical humanities but also for a fundamental rethinking of their grounding assumptions. Julia Kristeva (JK) has problematised the biomedical concept of health through her reading of the anthropogony of Cura (Care), who according to the Roman myth created man out of a piece of clay. JK uses this fable as an allegory for the cultural distinction between health construed as a ‘definitive state’, which belongs to biological life (bios), and healing as a durative ‘process with twists and turns in time’ that characterises human living (zoe). A consequence of this demarcation is that biomedicine is in constant need of ‘repairing’ and bridging the gap between bios and zoe, nature and culture. Even in radical versions, the medical humanities are mostly reduced to such an instrument of repairment, seeing them as what we refer to as a soft, ‘subjective’ and cultural supplement to a stable body of ‘objective’, biomedical and scientific knowledge. In this article, we present a prolegomenon to a more radical programme for the medical humanities, which calls the conventional distinctions between the humanities and the natural sciences into question, acknowledges the pathological and healing powers of culture, and sees the body as a complex biocultural fact. A key element in such a project is the rethinking of the concept of ‘evidence’ in healthcare. PMID:28935631

Interpretation of microstructures in high temperature deformation

DOE Office of Scientific and Technical Information (OSTI.GOV)

McQueen, H.J.

1999-07-01

In each historical period the microstructures produced by high temperature straining were probed by the current technology, this giving rise to new models and theories of rate controlling mechanisms. The progress in understanding has not been monotonic since occasionally theories were developed to high levels of sophistication while overlooking aspects of the substructure which were to become significant. New technologies such as TEM, or SEM-EBSP-OIM have made possible great leaps forward but often leave unresolved problems on a different scale. Experimental observations are presented of substructures in Al with solute, dynamic precipitates, dispersoids and reinforcing particles and in both austeniticmore » and ferritic stainless steels, thus providing a range of crystal structures and stacking fault energies (SFE). After the historical analysis, the current view of the hot-worked state will be presented with comparison of the conflicting theories. The analysis is centered on dislocation strain and there is only mention of pertinent interactions with grain boundary related deformation. The first seventy references point to research being done during the period that Prof. Julia Weertman (also the author) was pursuing research for the Ph.D. or starting a teaching career. it was an exciting time in which the applications of dislocation theory to cold working, recovery and creep were being confirmed by intragranular structural observations. Both the new modes of microscopic examination and the enhanced theories made possible the surge in fundamental understanding of hot working mechanisms that were summarized in the following twenty classic reviews. Finally, the remaining fifty references survey the current research which attempts to clarify the more complex details of the mechanisms: dynamic recovery (DRV) and dynamic recrystallization (DRX).« less

A New Fractal Model of Chromosome and DNA Processes

NASA Astrophysics Data System (ADS)

Bouallegue, K.

Dynamic chromosome structure remains unknown. Can fractals and chaos be used as new tools to model, identify and generate a structure of chromosomes?Fractals and chaos offer a rich environment for exploring and modeling the complexity of nature. In a sense, fractal geometry is used to describe, model, and analyze the complex forms found in nature. Fractals have also been widely not only in biology but also in medicine. To this effect, a fractal is considered an object that displays self-similarity under magnification and can be constructed using a simple motif (an image repeated on ever-reduced scales).It is worth noting that the problem of identifying a chromosome has become a challenge to find out which one of the models it belongs to. Nevertheless, the several different models (a hierarchical coiling, a folded fiber, and radial loop) have been proposed for mitotic chromosome but have not reached a dynamic model yet.This paper is an attempt to solve topological problems involved in the model of chromosome and DNA processes. By combining the fractal Julia process and the numerical dynamical system, we have finally found out four main points. First, we have developed not only a model of chromosome but also a model of mitosis and one of meiosis. Equally important, we have identified the centromere position through the numerical model captured below. More importantly, in this paper, we have discovered the processes of the cell divisions of both mitosis and meiosis. All in all, the results show that this work could have a strong impact on the welfare of humanity and can lead to a cure of genetic diseases.

Partitioned learning of deep Boltzmann machines for SNP data.

PubMed

Hess, Moritz; Lenz, Stefan; Blätte, Tamara J; Bullinger, Lars; Binder, Harald

2017-10-15

Learning the joint distributions of measurements, and in particular identification of an appropriate low-dimensional manifold, has been found to be a powerful ingredient of deep leaning approaches. Yet, such approaches have hardly been applied to single nucleotide polymorphism (SNP) data, probably due to the high number of features typically exceeding the number of studied individuals. After a brief overview of how deep Boltzmann machines (DBMs), a deep learning approach, can be adapted to SNP data in principle, we specifically present a way to alleviate the dimensionality problem by partitioned learning. We propose a sparse regression approach to coarsely screen the joint distribution of SNPs, followed by training several DBMs on SNP partitions that were identified by the screening. Aggregate features representing SNP patterns and the corresponding SNPs are extracted from the DBMs by a combination of statistical tests and sparse regression. In simulated case-control data, we show how this can uncover complex SNP patterns and augment results from univariate approaches, while maintaining type 1 error control. Time-to-event endpoints are considered in an application with acute myeloid leukemia patients, where SNP patterns are modeled after a pre-screening based on gene expression data. The proposed approach identified three SNPs that seem to jointly influence survival in a validation dataset. This indicates the added value of jointly investigating SNPs compared to standard univariate analyses and makes partitioned learning of DBMs an interesting complementary approach when analyzing SNP data. A Julia package is provided at 'http://github.com/binderh/BoltzmannMachines.jl'. binderh@imbi.uni-freiburg.de. Supplementary data are available at Bioinformatics online. © The Author (2017). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com

MPI as high temporal resolution imaging technique for in vivo bolus tracking of Ferucarbotran in mouse model

NASA Astrophysics Data System (ADS)

Jung, C.; Salamon, J.; Hofmann, M.; Kaul, M. G.; Adam, G.; Ittrich, H.; Knopp, T.

2016-03-01

Purpose: The goal of this study was to achieve a real time 3D visualisation of the murine cardiovascular system by intravenously injected superparamagnetic nanoparticles using Magnetic particle imaging (MPI). Material and Methods: MPI scans of FVB mice were performed using a 3D imaging sequence (1T/m gradient strength, 10mT drive-field strength). A dynamic scan with a temporal resolution of 21.5ms per 3D volume acquisition was performed. 50μl ferucarbotran (Resovist®, Bayer Healthcare AG) were injected into the tail vein after baseline MPI measurements. As MPI delivers no anatomic information, MRI scans at a 7T ClinScan (Bruker) were performed using a T2-weighted 2D TSE sequence. The reconstruction of the MPI data was performed on the MPI console (ParaVision 6.0/MPI, Bruker). Image fusion was done using additional image processing software (Imalytics, Philips). The dynamic information was extracted using custom software developed in the Julia programming environment. Results: The combined MRI-MPI measurements were carried out successfully. MPI data clearly demonstrated the passage of the SPIO tracer through the inferior vena cava, the heart and finally the liver. By co-registration with MRI the anatomical regions were identified. Due to the volume frame rate of about 46 volumes per second a signal modulation with the frequency of the heart beat was detectable and a heart beat of 520 beats per minute (bpm) has been assumed. Moreover, the blood flow velocity of approximately 5cm/s in the vena cava has been estimated. Conclusions: The high temporal resolution of MPI allows real-time imaging and bolus tracking of intravenous injected nanoparticles and offers a real time tool to assess blood flow velocity.

Sustainable Seas Student Monitoring Project at the Branson School in Ross, CA

NASA Astrophysics Data System (ADS)

Rainsford, A.; Soave, K.; Costolo, R.; Kudler, J.; Emunah, M.; Hatfield, J.; Kiyasu, J.

2015-12-01

Alina Rainsford, Kathy Soave, Julia Kudler, Jane Hatfield, Melea Emunah, Rose Costelo, Jenna Kiyasu, Amy Dean and Sustainable Seas Monitoring Project, Branson School, Ross, CA, United States, Farallones Marine Sanctuary Association, San Francisco, CA, United StatesAbstract:The Sustainable Seas Student Monitoring Project at the Branson School in Ross, CA has monitored Duxbury Reef in Bolinas, CA since 1999, in cooperation with the Farallones Marine Sanctuary Association and the Gulf of Farallones National Marine Sanctuary. Goals of this student-run project include: 1) To monitor the rocky intertidal habitat and develop a baseline database of invertebrates and algal density and abundance; 2) To contribute to the conservation of the rocky intertidal habitat through education of students and visitors about intertidal species; 3) To increase stewardship in the Gulf of the Farallones National Marine Sanctuary; and 4) To contribute abundance and population data on key algae and invertebrate species to the national database, LiMPETS (Long Term Monitoring Program & Experiential Training for Students). Each fall student volunteers complete an intensive training course on the natural history of intertidal invertebrates and algae, identification of key species, rocky intertidal monitoring techniques, and history of the sanctuary. Students identify and count key invertebrate and algae species along two permanent transects and, using randomly determined points, within two permanent 200 m2 areas, in fall, winter, and late spring. Using data from the previous years, we will compare population densities, seasonal abundance and long-term population trends of key algal and invertebrate species, including Tegula funebralis, Anthopluera elegantissima, Cladophora sp. and Fucus sp.. Future analyses and investigations will include intertidal abiotic factors (including water temperature, pH and human foot-traffic) to enhance insights into the Duxbury Reef ecosystem, in particular, the high and mid-intertidal zones experiencing the greatest amount of human impacts.

The Spanish Version of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Adolescents (UP-A) Adapted as a School-Based Anxiety and Depression Prevention Program: Study Protocol for a Cluster Randomized Controlled Trial.

PubMed

García-Escalera, Julia; Valiente, Rosa M; Chorot, Paloma; Ehrenreich-May, Jill; Kennedy, Sarah M; Sandín, Bonifacio

2017-08-21

Anxiety and depression are common, impairing conditions that evidence high comorbidity rates in adolescence. The Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Adolescents (UP-A) is one of the few existing resources aimed at applying transdiagnostic treatment principles to target core dysfunctions associated with both anxiety and depression within a single protocol. To our knowledge, this is the first study examining the efficacy of the UP-A adapted as a universal preventive intervention program. The primary aim of this study is to examine whether the Spanish version of the UP-A is more effective than a waitlist (WL) control group in reducing and preventing symptoms of anxiety and depression when employed as a universal, classroom-based preventive intervention. The secondary aim is to investigate changes in a broad range of secondary outcome measures, including negative and positive affect, anxiety sensitivity, emotional avoidance, top problems ratings, school grades, depression and anxiety-related interference, self-esteem, life satisfaction, quality of life, conduct problems, hyperactivity/inattention symptoms, peer problems, prosocial behavior, school adjustment, and discipline problems. Other aims are to assess a range of possible predictors of intervention effects and to examine the feasibility and the acceptability of implementing UP-A in a prevention group format and in a school setting. A cluster, randomized, WL, controlled trial design with classroom as the unit of randomization was used in this study. Five classes including a total of 152 adolescents were randomized to the experimental or WL control groups. Participants in the experimental group received 9 55-minute sessions delivered by advanced doctoral and masters students in clinical psychology. The WL control group will receive the intervention once the 3-month follow-up assessment is completed. We have recruited participants to the cluster randomized controlled trial (RCT) and have conducted the intervention with the experimental group. We expect the WL control group to complete the intervention in July 2017. Data analysis will take place during the second semester of 2017. We expect the experimental group to outperform the WL control group at post-intervention and 3-month follow-up. We also expect the WL control group to show improvements in primary and secondary outcome measures after receiving the intervention. Results will have implications for researchers, families, and education providers. Clinicaltrials.gov NCT03123991; https://clinicaltrials.gov/ct2/show/NCT03123991 (Archived by WebCite at http://www.webcitation.org/6qp7GIzcR). ©Julia García-Escalera, Rosa M Valiente, Paloma Chorot, Jill Ehrenreich-May, Sarah M Kennedy, Bonifacio Sandín. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 21.08.2017.

Domestic abuse as a transgressive practice: understanding nurses' responses through the lens of abjection.

PubMed

Bradbury-Jones, Caroline; Taylor, Julie

2013-10-01

Domestic abuse is a worldwide public health issue with long-term health and social consequences. Nurses play a key role in recognizing and responding to domestic abuse. Yet there is considerable evidence that their responses are often inappropriate and unhelpful, such as trivializing or ignoring the abuse. Empirical studies have identified several reasons why nurses' responses are sometimes wanting. These include organizational constraints, e.g. lack of time and privacy; and interpersonal factors such as fear of offending women and lack of confidence. We propose, however, that these factors present only a partial explanation. Drawing on the work of Julia Kristeva, we suggest that alternative understandings may be derived through applying the concept of abjection. Abjection is a psychological defence against any threat (the abject) to the clean and proper self that results in rejection of the abject. Using examples from our own domestic abuse research, we contend that exposure of nurses to the horror of domestic abuse evokes a state of abjection. Domestic abuse (the abject) transgresses established social boundaries of clean and proper. Thus when exposed to patients' and clients' experiences of it, some nurses subconsciously reject domestic abuse as a possibility (abjection). They do this to protect themselves from the horror of the act, but in so doing, render themselves unable to formulate appropriate responses. Rather than understanding the practice of some nurses as wilfully neglectful or ignorant, we argue that through a state of abjection, they are powerless to act. This does not refute existing evidence about nurses' responses to domestic abuse. Rather, as a relatively unknown concept in nursing, abjection provides an additional explanatory layer that accounts for why some nurses respond the way they do. Crucially, it elucidates the need for nurses to be supported emotionally when faced with the transgressive practice of abuse. © 2013 John Wiley & Sons Ltd.

Quantum Criticality and Superconductivity in β-YbAlB4

NASA Astrophysics Data System (ADS)

Nakatsuji, Satoru

2009-03-01

Heavy fermion systems have provided a number of prototypical compounds to study unconventional superconductivity and non-Fermi-liquid (NFL) states. A long standing issue in the research of heavy fermion superconductivity in 4f intermetallics is the dramatically different behavior between the electron like Ce (4f^1) and hole like Yb (4f^13) compounds. While superconductivity has been found in a number of Ce based heavy fermion compounds, no superconductivity has been reported for the corresponding Yb systems. In this talk, I present our recent finding of the superconductivity in the new heavy fermion system β-YbAlB4 [1-3]. The superconducting transition temperature is 80 mK, and above it, the system exhibits pronounced NFL behavior in the transport and thermodynamic properties [2,3]. Furthermore, the magnetic field dependence of the NFL behavior indicates that the system is a rare example of a pure metal that displays quantum criticality at ambient pressure and under zero magnetic field. Using our latest results, we discuss the detailed properties of superconductivity and quantum criticality. This is the work performed in collaboration with K. Kuga, Y. Matsumoto, T. Tomita, Y. Machida, T. Tayama, T. Sakakibara, Y. Karaki, H. Ishimoto, S. Yonezawa, Y. Maeno, E. Pearson, G. G. Lonzarich, L.Balicas, H. Lee, and Z. Fisk. [4pt] [1] Robin T. Macaluso, Satoru Nakatsuji, Kentaro Kuga, Evan Lyle Thomas, Yo Machida, Yoshiteru Maeno, Zachary Fisk, and Julia Y. Chan, Chem. Mater. 19 1918 (2007). [0pt] [2] S. Nakatsuji, K.Kuga, Y. Machida, T. Tayama, T. Sakakibara, Y. Karaki, H. Ishimoto, S. Yonezawa, Y. Maeno, E. Pearson, G. G. Lonzarich, L.Balicas, H. Lee, and Z. Fisk, Nature Phys 4, 603-607 (2008). [0pt] [3] K. Kuga, Y. Karaki, Y. Matsumoto, Y. Machida, and S. Nakatsuji, Phys. Rev. Lett. 101, 137004 (2008).

Understanding the limits of animal models as predictors of human biology: lessons learned from the sbv IMPROVER Species Translation Challenge

PubMed Central

Mathis, Carole; Dulize, Rémi H. J.; Ivanov, Nikolai V.; Alexopoulos, Leonidas; Jeremy Rice, J.; Peitsch, Manuel C.; Stolovitzky, Gustavo; Meyer, Pablo; Hoeng, Julia

2015-01-01

Motivation: Inferring how humans respond to external cues such as drugs, chemicals, viruses or hormones is an essential question in biomedicine. Very often, however, this question cannot be addressed because it is not possible to perform experiments in humans. A reasonable alternative consists of generating responses in animal models and ‘translating’ those results to humans. The limitations of such translation, however, are far from clear, and systematic assessments of its actual potential are urgently needed. sbv IMPROVER (systems biology verification for Industrial Methodology for PROcess VErification in Research) was designed as a series of challenges to address translatability between humans and rodents. This collaborative crowd-sourcing initiative invited scientists from around the world to apply their own computational methodologies on a multilayer systems biology dataset composed of phosphoproteomics, transcriptomics and cytokine data derived from normal human and rat bronchial epithelial cells exposed in parallel to 52 different stimuli under identical conditions. Our aim was to understand the limits of species-to-species translatability at different levels of biological organization: signaling, transcriptional and release of secreted factors (such as cytokines). Participating teams submitted 49 different solutions across the sub-challenges, two-thirds of which were statistically significantly better than random. Additionally, similar computational methods were found to range widely in their performance within the same challenge, and no single method emerged as a clear winner across all sub-challenges. Finally, computational methods were able to effectively translate some specific stimuli and biological processes in the lung epithelial system, such as DNA synthesis, cytoskeleton and extracellular matrix, translation, immune/inflammation and growth factor/proliferation pathways, better than the expected response similarity between species. Contact: pmeyerr@us.ibm.com or Julia.Hoeng@pmi.com Supplementary information: Supplementary data are available at Bioinformatics online. PMID:25236459

Phylogenetic comparative methods on phylogenetic networks with reticulations.

PubMed

Bastide, Paul; Solís-Lemus, Claudia; Kriebel, Ricardo; Sparks, K William; Ané, Cécile

2018-04-25

The goal of Phylogenetic Comparative Methods (PCMs) is to study the distribution of quantitative traits among related species. The observed traits are often seen as the result of a Brownian Motion (BM) along the branches of a phylogenetic tree. Reticulation events such as hybridization, gene flow or horizontal gene transfer, can substantially affect a species' traits, but are not modeled by a tree. Phylogenetic networks have been designed to represent reticulate evolution. As they become available for downstream analyses, new models of trait evolution are needed, applicable to networks. One natural extension of the BM is to use a weighted average model for the trait of a hybrid, at a reticulation point. We develop here an efficient recursive algorithm to compute the phylogenetic variance matrix of a trait on a network, in only one preorder traversal of the network. We then extend the standard PCM tools to this new framework, including phylogenetic regression with covariates (or phylogenetic ANOVA), ancestral trait reconstruction, and Pagel's λ test of phylogenetic signal. The trait of a hybrid is sometimes outside of the range of its two parents, for instance because of hybrid vigor or hybrid depression. These two phenomena are rather commonly observed in present-day hybrids. Transgressive evolution can be modeled as a shift in the trait value following a reticulation point. We develop a general framework to handle such shifts, and take advantage of the phylogenetic regression view of the problem to design statistical tests for ancestral transgressive evolution in the evolutionary history of a group of species. We study the power of these tests in several scenarios, and show that recent events have indeed the strongest impact on the trait distribution of present-day taxa. We apply those methods to a dataset of Xiphophorus fishes, to confirm and complete previous analysis in this group. All the methods developed here are available in the Julia package PhyloNetworks.

Cultural crossings of care: An appeal to the medical humanities.

PubMed

Kristeva, Julia; Moro, Marie Rose; Ødemark, John; Engebretsen, Eivind

2018-03-01

Modern medicine is confronted with cultural crossings in various forms. In facing these challenges, it is not enough to simply increase our insight into the cultural dimensions of health and well-being. We must, more radically, question the conventional distinction between the 'objectivity of science' and the 'subjectivity of culture'. This obligation creates an urgent call for the medical humanities but also for a fundamental rethinking of their grounding assumptions.Julia Kristeva (JK) has problematised the biomedical concept of health through her reading of the anthropogony of Cura (Care), who according to the Roman myth created man out of a piece of clay. JK uses this fable as an allegory for the cultural distinction between health construed as a 'definitive state', which belongs to biological life ( bios ), and healing as a durative 'process with twists and turns in time' that characterises human living ( zoe ). A consequence of this demarcation is that biomedicine is in constant need of 'repairing' and bridging the gap between bios and zoe, nature and culture. Even in radical versions, the medical humanities are mostly reduced to such an instrument of repairment, seeing them as what we refer to as a soft, 'subjective' and cultural supplement to a stable body of 'objective', biomedical and scientific knowledge. In this article, we present a prolegomenon to a more radical programme for the medical humanities, which calls the conventional distinctions between the humanities and the natural sciences into question, acknowledges the pathological and healing powers of culture, and sees the body as a complex biocultural fact. A key element in such a project is the rethinking of the concept of 'evidence' in healthcare. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Web Use for Symptom Appraisal of Physical Health Conditions: A Systematic Review.

PubMed

Mueller, Julia; Jay, Caroline; Harper, Simon; Davies, Alan; Vega, Julio; Todd, Chris

2017-06-13

The Web has become an important information source for appraising symptoms. We need to understand the role it currently plays in help seeking and symptom evaluation to leverage its potential to support health care delivery. The aim was to systematically review the literature currently available on Web use for symptom appraisal. We searched PubMed, EMBASE, PsycINFO, ACM Digital Library, SCOPUS, and Web of Science for any empirical studies that addressed the use of the Web by lay people to evaluate symptoms for physical conditions. Articles were excluded if they did not meet minimum quality criteria. Study findings were synthesized using a thematic approach. A total of 32 studies were included. Study designs included cross-sectional surveys, qualitative studies, experimental studies, and studies involving website/search engine usage data. Approximately 35% of adults engage in Web use for symptom appraisal, but this proportion varies between 23% and 75% depending on sociodemographic and disease-related factors. Most searches were symptom-based rather than condition-based. Users viewed only the top search results and interacted more with results that mentioned serious conditions. Web use for symptom appraisal appears to impact on the decision to present to health services, communication with health professionals, and anxiety. Web use for symptom appraisal has the potential to influence the timing of help seeking for symptoms and the communication between patients and health care professionals during consultations. However, studies lack suitable comparison groups as well as follow-up of participants over time to determine whether Web use results in health care utilization and diagnosis. Future research should involve longitudinal follow-up so that we can weigh the benefits of Web use for symptom appraisal (eg, reductions in delays to diagnosis) against the disadvantages (eg, unnecessary anxiety and health care use) and relate these to health care costs. ©Julia Mueller, Caroline Jay, Simon Harper, Alan Davies, Julio Vega, Chris Todd. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 13.06.2017.

Tectonic evolution of the South Fiji Basin: UNCLOS helps tackle regional tectonics

NASA Astrophysics Data System (ADS)

Herzer, R.; Roest, W.; Barker, D.; Mortimer, N.; Mauffret, A.; Lafoy, Y.

2005-12-01

Marine surveys to study the evolution of remnant arcs and backarc basins north of New Zealand have been complemented by UNCLOS surveys by three countries - France, New Zealand and Australia - with potential extended continental shelf claims in the region. The UNCLOS factor allowed 9 cruises to focus on the region in the past 9 years, collecting approximately 30,000 km of seismic reflection (5,000 deep crustal), 263,700 sq km of swath bathymetry, and 70 dredge samples. Feedback through sharing or publishing data and joint participation allowed efficient planning and deployment of academic and UNCLOS cruises. Two models for South Fiji (SFB) and Norfolk (NB) basin evolution arise from current studies: at the level of the Three Kings Ridge - NB - southern SFB both involve Pacific trench roll-back and southward propagating spreading, but one also uses two subduction systems and arc-continent collision. Linked spreading of the NB and SFB is invoked in both models, but the veracity and geodynamics of the link are not investigated. A growing body of petrological and radiometric evidence and the tectonics of the New Zealand continental margin point to tandem Early Miocene spreading of the SFB and NB despite published magnetic interpretations that would confine SFB spreading to the Oligocene. The Franco-NZ NOUCAPLAC-1 cruise, the last cruise relevant to UNCLOS in this region, included a scientific objective to investigate the SFB-NB link in the critical area bounded by the Loyalty Ridge (LR), the Cook Fracture Zone (CFZ), the Bounty spreading centre (BSC) and the Julia Lineament (JL) with swath mapping, magnetics and seismic reflection. Initial results show a complex bathymetry where a possible link between the BSC and the CFZ involves ridge propagation, overlapping spreading centres, rift blocks and overprinting volcanoes. The link to the JL was not adequately tested due to sparse coverage. Closer to the LR, a thick, faulted sedimentary basin was found.

Testing the application of Teflon/quartz soil solution samplers for DOM sampling in the Critical Zone: Field and laboratory approaches

NASA Astrophysics Data System (ADS)

Dolan, E. M.; Perdrial, J. N.; Vazquez, A.; Hernández, S.; Chorover, J.

2010-12-01

Elizabeth Dolan1,2, Julia Perdrial3, Angélica Vázquez-Ortega3, Selene Hernández-Ruiz3, Jon Chorover3 1Deptartment of Soil, Environmental, and Atmospheric Science, University of Missouri. 2Biosphere 2, University of Arizona. 3Deptartment of Soil, Water, and Environmental Science, University of Arizona. Abstract: The behavior of dissolved organic matter (DOM) in soil is important to many biogeochemical processes. Extraction methods to obtain DOM from the unsaturated zone remain a current focus of research as different methods can influence the type and concentration of DOM obtained. Thus, the present comparison study involves three methods for soil solution sampling to assess their impact on DOM quantity and quality: 1) aqueous soil extracts, 2) solution yielded from laboratory installed suction cup samplers and 3) solutions from field installed suction cup samplers. All samples were analyzed for dissolved organic carbon and total nitrogen concentrations. Moreover, DOM quality was analyzed using fluorescence, UV-Vis and FTIR spectroscopies. Results indicate higher DOC values for laboratory extracted DOM: 20 mg/L for aqueous soil extracts and 31 mg/L for lab installed samplers compared to 12 mg/L for field installed samplers. Large variations in C/N ratios were also observed ranging from 1.5 in laboratory extracted DOM to 11 in field samples. Fluorescence excitation-emission matrices of DOM solutions obtained for the laboratory extraction methods showed higher intensities in regions typical for fulvic and humic acid-like materials relative to those extracted in the field. Similarly, the molar absorptivity calculated from DOC concentration normalization of UV-Vis absorbance of the laboratory-derived solutions was significantly higher as well, indicating greater aromaticity. The observed differences can be attributed to soil disturbance associated with obtaining laboratory derived solution samples. Our results indicate that laboratory extraction methods are not comparable to in-situ field soil solution extraction in terms of DOM.

Comparison of Online Survey Recruitment Platforms for Hard-to-Reach Pregnant Smoking Populations: Feasibility Study.

PubMed

Ibarra, Jose Luis; Agas, Jessica Marie; Lee, Melissa; Pan, Julia Lily; Buttenheim, Alison Meredith

2018-04-16

Recruiting hard-to-reach populations for health research is challenging. Web-based platforms offer one way to recruit specific samples for research purposes, but little is known about the feasibility of online recruitment and the representativeness and comparability of samples recruited through different Web-based platforms. The objectives of this study were to determine the feasibility of recruiting a hard-to-reach population (pregnant smokers) using 4 different Web-based platforms and to compare participants recruited through each platform. A screener and survey were distributed online through Qualtrics Panel, Soapbox Sample, Reddit, and Amazon Mechanical Turk (mTurk). Descriptive statistics were used to summarize results of each recruitment platform, including eligibility yield, quality yield, income, race, age, and gestational age. Of the 3847 participants screened for eligibility across all 4 Web-based platforms, 535 were eligible and 308 completed the survey. Amazon mTurk yielded the fewest completed responses (n=9), 100% (9/9) of which passed several quality metrics verifying pregnancy and smoking status. Qualtrics Panel yielded 14 completed responses, 86% (12/14) of which passed the quality screening. Soapbox Sample produced 107 completed surveys, 67% (72/107) of which were found to be quality responses. Advertising through Reddit produced the highest completion rate (n=178), but only 29.2% (52/178) of those surveys passed the quality metrics. We found significant differences in eligibility yield, quality yield, age, number of previous pregnancies, age of smoking initiation, current smokers, race, education, and income (P<.001). Although each platform successfully recruited pregnant smokers, results varied in quality, cost, and percentage of complete responses. Moving forward, investigators should pay careful attention to the percentage yield and cost of online recruitment platforms to maximize internal and external validity. ©Jose Luis Ibarra, Jessica Marie Agas, Melissa Lee, Julia Lily Pan, Alison Meredith Buttenheim. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 16.04.2018.

Forest Resources, Chiefdoms and Mortuary Practices in the Neotropics: Preliminary Archaeobotanical Analysis from El Caño Funerary Complex (Coclé Province, Panamá)

NASA Astrophysics Data System (ADS)

Martín Seijo, M.; Torné, J. Mayo; Torné, C. Mayo; Huerta, R. Piqué i.

2012-04-01

El Caño site is situated on the Pacific side of Panamá, near the Río Grande. It's a funerary complex comprising different types of structures (stone structures -basalt columns, groups of sculptures and a causeway-; earthen mounds and canals; burials). The excavations supervised by Julia Mayo between 2008 and 2011 allowed to discover several lavish burials estimated to date between 700 and 1000 AD (Mayo & Mayo 2012). The data recovered has served as source of information for the pre-Columbian chiefdoms and their mortuary practices. There was carried out a detailed taphonomic study to register the complex formation processes of these burial deposits, and the significant post-depositional transformations (anthropogenic and natural processes) (Mayo & Mayo in press). Also during the excavations were recovered archaeobotanical samples; most of them charcoals. The laboratory work process consisted in the exhaustive description of the anatomical features of the different taxa identified during the charcoal analyses (the identification level varied from species to family, although in several case we couldn't propose any taxa). These samples were concentrated in structures, and in few cases dispersed in the sediment. Some of the samples analyzed were large pieces of charcoal of the wooden beams from ancient wood structures, and other pieces of charcoal and vegetable fibers were related directly with the burial practices. The charcoal analysis results aim to contribute to the knowledge of the exploitation of forest resources, of the territories where these resources were collected, and of the production process (chaîne opératoire). These results were complemented with the exhaustive review of written sources (spanish chronicles), ethnobotanical studies and archaeological data of other sites in this area. Acknowledgements: This research was developed under El Caño Archaeological Project and was funded by SENACYT (Secretaría Nacional de Ciencia y Tecnología de Panamá).

Understanding the limits of animal models as predictors of human biology: lessons learned from the sbv IMPROVER Species Translation Challenge.

PubMed

Rhrissorrakrai, Kahn; Belcastro, Vincenzo; Bilal, Erhan; Norel, Raquel; Poussin, Carine; Mathis, Carole; Dulize, Rémi H J; Ivanov, Nikolai V; Alexopoulos, Leonidas; Rice, J Jeremy; Peitsch, Manuel C; Stolovitzky, Gustavo; Meyer, Pablo; Hoeng, Julia

2015-02-15

Inferring how humans respond to external cues such as drugs, chemicals, viruses or hormones is an essential question in biomedicine. Very often, however, this question cannot be addressed because it is not possible to perform experiments in humans. A reasonable alternative consists of generating responses in animal models and 'translating' those results to humans. The limitations of such translation, however, are far from clear, and systematic assessments of its actual potential are urgently needed. sbv IMPROVER (systems biology verification for Industrial Methodology for PROcess VErification in Research) was designed as a series of challenges to address translatability between humans and rodents. This collaborative crowd-sourcing initiative invited scientists from around the world to apply their own computational methodologies on a multilayer systems biology dataset composed of phosphoproteomics, transcriptomics and cytokine data derived from normal human and rat bronchial epithelial cells exposed in parallel to 52 different stimuli under identical conditions. Our aim was to understand the limits of species-to-species translatability at different levels of biological organization: signaling, transcriptional and release of secreted factors (such as cytokines). Participating teams submitted 49 different solutions across the sub-challenges, two-thirds of which were statistically significantly better than random. Additionally, similar computational methods were found to range widely in their performance within the same challenge, and no single method emerged as a clear winner across all sub-challenges. Finally, computational methods were able to effectively translate some specific stimuli and biological processes in the lung epithelial system, such as DNA synthesis, cytoskeleton and extracellular matrix, translation, immune/inflammation and growth factor/proliferation pathways, better than the expected response similarity between species. pmeyerr@us.ibm.com or Julia.Hoeng@pmi.com Supplementary data are available at Bioinformatics online. © The Author 2014. Published by Oxford University Press.

Acute Effect of Alcohol Intake on Cardiovascular Autonomic Regulation During the First Hours of Sleep in a Large Real-World Sample of Finnish Employees: Observational Study.

PubMed

Pietilä, Julia; Helander, Elina; Korhonen, Ilkka; Myllymäki, Tero; Kujala, Urho M; Lindholm, Harri

2018-03-16

Sleep is fundamental for good health, and poor sleep has been associated with negative health outcomes. Alcohol consumption is a universal health behavior associated with poor sleep. In controlled laboratory studies, alcohol intake has been shown to alter physiology and disturb sleep homeostasis and architecture. The association between acute alcohol intake and physiological changes has not yet been studied in noncontrolled real-world settings. The aim of this study was to assess the effects of alcohol intake on the autonomic nervous system (ANS) during sleep in a large noncontrolled sample of Finnish employees. From a larger cohort, this study included 4098 subjects (55.81%, 2287/4098 females; mean age 45.1 years) who had continuous beat-to-beat R-R interval recordings of good quality for at least 1 day with and for at least 1 day without alcohol intake. The participants underwent continuous beat-to-beat R-R interval recording during their normal everyday life and self-reported their alcohol intake as doses for each day. Heart rate (HR), HR variability (HRV), and HRV-derived indices of physiological state from the first 3 hours of sleep were used as outcomes. Within-subject analyses were conducted in a repeated measures manner by studying the differences in the outcomes between each participant's days with and without alcohol intake. For repeated measures two-way analysis of variance, the participants were divided into three groups: low (≤0.25 g/kg), moderate (>0.25-0.75 g/kg), and high (>0.75 g/kg) intake of pure alcohol. Moreover, linear models studied the differences in outcomes with respect to the amount of alcohol intake and the participant's background parameters (age; gender; body mass index, BMI; physical activity, PA; and baseline sleep HR). Alcohol intake was dose-dependently associated with increased sympathetic regulation, decreased parasympathetic regulation, and insufficient recovery. In addition to moderate and high alcohol doses, the intraindividual effects of alcohol intake on the ANS regulation were observed also with low alcohol intake (all P<.001). For example, HRV-derived physiological recovery state decreased on average by 9.3, 24.0, and 39.2 percentage units with low, moderate, and high alcohol intake, respectively. The effects of alcohol in suppressing recovery were similar for both genders and for physically active and sedentary subjects but stronger among young than older subjects and for participants with lower baseline sleep HR than with higher baseline sleep HR. Alcohol intake disturbs cardiovascular relaxation during sleep in a dose-dependent manner in both genders. Regular PA or young age do not protect from these effects of alcohol. In health promotion, wearable HR monitoring and HRV-based analysis of recovery might be used to demonstrate the effects of alcohol on sleep on an individual level. ©Julia Pietilä, Elina Helander, Ilkka Korhonen, Tero Myllymäki, Urho M Kujala, Harri Lindholm. Originally published in JMIR Mental Health (http://mental.jmir.org), 16.03.2018.

Testing the Feasibility of Remote Patient Monitoring in Prenatal Care Using a Mobile App and Connected Devices: A Prospective Observational Trial.

PubMed

Marko, Kathryn I; Krapf, Jill M; Meltzer, Andrew C; Oh, Julia; Ganju, Nihar; Martinez, Anjali G; Sheth, Sheetal G; Gaba, Nancy D

2016-11-18

Excessive weight gain and elevated blood pressure are significant risk factors for adverse pregnancy outcomes such as gestational diabetes, premature birth, and preeclampsia. More effective strategies to facilitate adherence to gestational weight gain goals and monitor blood pressure may have a positive health benefit for pregnant women and their babies. The impact of utilizing a remote patient monitoring system to monitor blood pressure and weight gain as a component of prenatal care has not been previously assessed. The objective of this study is to determine the feasibility of monitoring patients remotely in prenatal care using a mobile phone app and connected digital devices. In this prospective observational study, 8 women with low risk pregnancy in the first trimester were recruited at an urban academic medical center. Participants received a mobile phone app with a connected digital weight scale and blood pressure cuff for at-home data collection for the duration of pregnancy. At-home data was assessed for abnormal values of blood pressure or weight to generate clinical alerts to the patient and provider. As measures of the feasibility of the system, participants were studied for engagement with the app, accuracy of remote data, efficacy of alert system, and patient satisfaction. Patient engagement with the mobile app averaged 5.5 times per week over the 6-month study period. Weight data collection and blood pressure data collection averaged 1.5 times and 1.1 times per week, respectively. At-home measurements of weight and blood pressure were highly accurate compared to in-office measurements. Automatic clinical alerts identified two episodes of abnormal weight gain with no false triggers. Patients demonstrated high satisfaction with the system. In this pilot study, we demonstrated that a system using a mobile phone app coupled to remote monitoring devices is feasible for prenatal care. ©Kathryn I Marko, Jill M Krapf, Andrew C Meltzer, Julia Oh, Nihar Ganju, Anjali G Martinez, Sheetal G Sheth, Nancy D Gaba. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 18.11.2016.

Longitudinal Differences of Ionospheric Vertical Density Distribution and Equatorial Electrodynamics

NASA Technical Reports Server (NTRS)

Yizengaw, E.; Zesta, E.; Moldwin, M. B.; Damtie, B.; Mebrahtu, A.; Valledares, C.E.; Pfaff, R. F.

2012-01-01

Accurate estimation of global vertical distribution of ionospheric and plasmaspheric density as a function of local time, season, and magnetic activity is required to improve the operation of space-based navigation and communication systems. The vertical density distribution, especially at low and equatorial latitudes, is governed by the equatorial electrodynamics that produces a vertical driving force. The vertical structure of the equatorial density distribution can be observed by using tomographic reconstruction techniques on ground-based global positioning system (GPS) total electron content (TEC). Similarly, the vertical drift, which is one of the driving mechanisms that govern equatorial electrodynamics and strongly affect the structure and dynamics of the ionosphere in the low/midlatitude region, can be estimated using ground magnetometer observations. We present tomographically reconstructed density distribution and the corresponding vertical drifts at two different longitudes: the East African and west South American sectors. Chains of GPS stations in the east African and west South American longitudinal sectors, covering the equatorial anomaly region of meridian approx. 37 deg and 290 deg E, respectively, are used to reconstruct the vertical density distribution. Similarly, magnetometer sites of African Meridian B-field Education and Research (AMBER) and INTERMAGNET for the east African sector and South American Meridional B-field Array (SAMBA) and Low Latitude Ionospheric Sensor Network (LISN) are used to estimate the vertical drift velocity at two distinct longitudes. The comparison between the reconstructed and Jicamarca Incoherent Scatter Radar (ISR) measured density profiles shows excellent agreement, demonstrating the usefulness of tomographic reconstruction technique in providing the vertical density distribution at different longitudes. Similarly, the comparison between magnetometer estimated vertical drift and other independent drift observation, such as from VEFI onboard Communication/Navigation Outage Forecasting System (C/NOFS) satellite and JULIA radar, is equally promising. The observations at different longitudes suggest that the vertical drift velocities and the vertical density distribution have significant longitudinal differences; especially the equatorial anomaly peaks expand to higher latitudes more in American sector than the African sector, indicating that the vertical drift in the American sector is stronger than the African sector.

PREFACE: 2nd International Conference and Young Scientist School ''Magnetic resonance imaging in biomedical research''

NASA Astrophysics Data System (ADS)

Naumova, A. V.; Khodanovich, M. Y.; Yarnykh, V. L.

2016-02-01

The Second International Conference and Young Scientist School ''Magnetic resonance imaging in biomedical research'' was held on the campus of the National Research Tomsk State University (Tomsk, Russia) on September 7-9, 2015. The conference was focused on magnetic resonance imaging (MRI) applications for biomedical research. The main goal was to bring together basic scientists, clinical researchers and developers of new MRI techniques to bridge the gap between clinical/research needs and advanced technological solutions. The conference fostered research and development in basic and clinical MR science and its application to health care. It also had an educational purpose to promote understanding of cutting-edge MR developments. The conference provided an opportunity for researchers and clinicians to present their recent theoretical developments, practical applications, and to discuss unsolved problems. The program of the conference was divided into three main topics. First day of the conference was devoted to educational lectures on the fundamentals of MRI physics and image acquisition/reconstruction techniques, including recent developments in quantitative MRI. The second day was focused on developments and applications of new contrast agents. Multinuclear and spectroscopic acquisitions as well as functional MRI were presented during the third day of the conference. We would like to highlight the main developments presented at the conference and introduce the prominent speakers. The keynote speaker of the conference Dr. Vasily Yarnykh (University of Washington, Seattle, USA) presented a recently developed MRI method, macromolecular proton fraction (MPF) mapping, as a unique tool for modifying image contrast and a unique tool for quantification of the myelin content in neural tissues. Professor Yury Pirogov (Lomonosov Moscow State University) described development of new fluorocarbon compounds and applications for biomedicine. Drs. Julia Velikina and Alexey Samsonov (University of Wisconsin-Madison, USA) demonstrated new image reconstruction methods for accelerated quantitative parameter mapping and magnetic resonance angiography. Finally, we would like to thank the scientific committee, the local organizing committee and the National Research Tomsk State University for giving an opportunity to share scientific ideas and new developments at the conference and the Russian Science Foundation (project № 14-45-00040) for financial support.

Timing of surgical antimicrobial prophylaxis: a phase 3 randomised controlled trial.

PubMed

Weber, Walter P; Mujagic, Edin; Zwahlen, Marcel; Bundi, Marcel; Hoffmann, Henry; Soysal, Savas D; Kraljević, Marko; Delko, Tarik; von Strauss, Marco; Iselin, Lukas; Da Silva, Richard X Sousa; Zeindler, Jasmin; Rosenthal, Rachel; Misteli, Heidi; Kindler, Christoph; Müller, Peter; Saccilotto, Ramon; Lugli, Andrea Kopp; Kaufmann, Mark; Gürke, Lorenz; von Holzen, Urs; Oertli, Daniel; Bucheli-Laffer, Evelin; Landin, Julia; Widmer, Andreas F; Fux, Christoph A; Marti, Walter R

2017-06-01

Based on observational studies, administration of surgical antimicrobial prophylaxis (SAP) for the prevention of surgical site infection (SSI) is recommended within 60 min before incision. However, the precise optimum timing is unknown. This trial compared early versus late administration of SAP before surgery. In this phase 3 randomised controlled superiority trial, we included general surgery adult inpatients (age ≥18 years) at two Swiss hospitals in Basel and Aarau. Patients were randomised centrally and stratified by hospital according to a pre-existing computer-generated list in a 1:1 ratio to receive SAP early in the anaesthesia room or late in the operating room. Patients and the outcome assessment team were blinded to group assignment. SAP consisted of single-shot, intravenous infusion of 1·5 g of cefuroxime, a commonly used cephalosporin with a short half-life, over 2-5 min (combined with 500 mg metronidazole in colorectal surgery). The primary endpoint was the occurrence of SSI within 30 days of surgery. The main analyses were by intention to treat. The trial is registered with ClinicalTrials.gov, number NCT01790529. Between Feb 21, 2013, and Aug 3, 2015, 5580 patients were randomly assigned to receive SAP early (2798 patients) or late (2782 patients). 5175 patients (2589 in the early group and 2586 in the late group) were analysed. Median administration time was 42 min before incision in the early group (IQR 30-55) and 16 min before incision in the late group (IQR 10-25). Inpatient follow-up rate was 100% (5175 of 5175 patients); outpatient 30-day follow-up rate was 88·8% (4596 of 5175), with an overall SSI rate of 5·1% (234 of 4596). Early administration of SAP did not significantly reduce the risk of SSI compared with late administration (odds ratio 0·93, 95% CI 0·72-1·21, p=0·601). Our findings do not support any narrowing of the 60-min window for the administration of a cephalosporin with a short half-life, thereby obviating the need for increasingly challenging SAP timing recommendations. Swiss National Science Foundation, Hospital of Aarau, University of Basel, Gottfried und Julia Bangerter-Rhyner Foundation, Hippocrate Foundation, and Nora van Meeuwen-Häfliger Foundation. Copyright © 2017 Elsevier Ltd. All rights reserved.

A 500-year overview and analysis of flood changes in Europe: preliminary results

NASA Astrophysics Data System (ADS)

Kiss, Andrea

2014-05-01

Long-term flood series can be gained by combining evidence and systematic hydrological observations. Following various already existing local and regional studies, an important aim of the present work is to create a broad European database of long flood chronologies and to use them for detecting changes in flood regimes with respect to common break points. Another aim of the investigations is to reveal the main causes (e.g. atmospheric, human) of these changes and study spatial and temporal variability of floods on a European scale. In the presentation we provide an overview on the current stage of these Europe-wide investigations, including the available source types (i.e. documentary and instrumental), geographical coverage, temporal and spatial distribution of long-term flood series applied in the study. The first research results concerns basic information on magnitude, frequency and seasonality of floods (with special consideration of detectable changes). Full list of authors in alphabetic order: Mariano Barriendos (1), Günter Blöschl (2), Rudolf Brázdil (3), Gerardo Benito (4), Chiara Bertolin (5), Dario Camuffo (5), Gaston Demarée (6), Líbor Elleder (7), Silvi Enzi (8), Rüdiger Glaser (9), Julia Hall (2), Andrea Kiss (2), Oldrich Kotyza (10), Carmen Maria del Llasat (1), Neil MacDonald (11), Rui Perdigao (2), Dag Retsö (12), Lars Roald (13), Josep Luis Ruiz Bellet (1), Johannes Schönbeim (9), Petra Schmocker-Fackel (14), Lothar Schulte (1), Hubert Valasek (15), Oliver Wetter (16) (1) Faculty of Geography and History, University of Barcelona, Spain (2) Institute of Hydrological Engineering and Water Resources Management, TU Wien (3) Institute of Geography, Masaryk University Brno, Czech Republic (4) Laboratory of Hydrology and Geomorphology, Center of Env. Sciences, Madrid, Spain (5) Institute of Atmospheric Sciences and Climate, National Research Council, Rome, Italy (6) Royal Meteorological Institute, Brussels, Belgium (7) Research Group of Hydrology, Charles University, Prague, Czech Republic (8) Kleio - Studio Associato di Ricerca, Padova, Italy (9) Department of Geography, University of Freiburg, Germany (10) Regional Museum, Litomerice, Czech Republic (11) Department of Geography and Planning, University of Liverpool, Great Britain (12) Department of Economic History, Stockholm University, Sweden (13) Norwegian Water Resources and Energy Administration, Norway (14) Swiss Federal Institute of Technology, Zurich, Switzerland (15) Moravian Land Archives, Brno, Czech Republic (16) Institute of History, University of Bern, Switzerland

Behavioral Interventions to Prevent or Delay Dementia: Protocol for a Randomized Comparative Effectiveness Study.

PubMed

Smith, Glenn; Chandler, Melanie; Locke, Dona Ec; Fields, Julie; Phatak, Vaishali; Crook, Julia; Hanna, Sherrie; Lunde, Angela; Morris, Miranda; Graff-Radford, Michelle; Hughes, Christine A; Lepore, Susan; Cuc, Andrea; Caselli, Maria; Hurst, Duane; Wethe, Jennifer; Francone, Andrea; Eilertsen, Jeanne; Lucas, Pauline; Hoffman Snyder, Charlene; Kuang, LeeAnn; Becker, Marigrace; Dean, Pamela; Diehl, Nancy; Lofquist, Marvin; Vanderhook, Shirley; Myles, Diana; Cochran, Denise

2017-11-27

Currently, people at risk for dementia and their caregivers are confronted with confusing choices about what behavioral interventions are most effective. The objective of this study is to determine which empirically supported behavioral interventions most impact the outcomes highly valued by patients with mild cognitive impairment and their partners. This protocol describes a comparative effectiveness trial targeting 300 participants with mild cognitive impairment and their study partners. The trial is being conducted at the Mayo Clinic campuses in Arizona, Florida, Minnesota, and the University of Washington in Seattle. The study examines the contribution of five behavioral interventions (yoga, memory compensation training, computerized cognitive training, support groups, and wellness education) on primary outcomes of participant and partner quality of life and self-efficacy. In this unique 10-day multicomponent intervention, groups of couples were randomized to have one of the five interventions withheld while receiving the other four. Although the longitudinal follow-up is still under way, enrollment results are available and reported. In total, 272 couples have been enrolled in the trial and follow-up visits continue. Outcomes will be assessed at the end-of-intervention and 6-, 12-, and 18-month follow-ups. We anticipate reporting on our primary and secondary outcomes across time points in the next 2 years. This paper describes the protocol for a randomized comparative effectiveness study of behavioral interventions to prevent or delay dementia. We describe of the rationale, design, power analysis, and analysis plan. Also because enrollment is complete and we are in follow-up phases of the study, we have included enrollment data from the trial.  ClinicalTrials.gov NCT02265757; http://clinicaltrials.gov/ctsshow/ NCT02265757 (Archived by WebCite at http://www.webcitation.org/6ueRfwSYv). ©Glenn Smith, Melanie Chandler, Dona EC Locke, Julie Fields, Vaishali Phatak, Julia Crook, Sherrie Hanna, Angela Lunde, Miranda Morris, Michelle Graff-Radford, Christine A Hughes, Susan Lepore, Andrea Cuc, Maria Caselli, Duane Hurst, Jennifer Wethe, Andrea Francone, Jeanne Eilertsen, Pauline Lucas, Charlene Hoffman Snyder, LeeAnn Kuang, Marigrace Becker, Pamela Dean, Nancy Diehl, Marvin Lofquist, Shirley Vanderhook, Diana Myles, Denise Cochran. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 27.11.2017.

Observations of land-atmosphere interactions using satellite data

NASA Astrophysics Data System (ADS)

Green, Julia; Gentine, Pierre; Konings, Alexandra; Alemohammad, Hamed; Kolassa, Jana

2016-04-01

Observations of land-atmosphere interactions using satellite data Julia Green (1), Pierre Gentine (1), Alexandra Konings (1,2), Seyed Hamed Alemohammad (3), Jana Kolassa (4) (1) Columbia University, Earth and Environmental Engineering, NY, NY, USA, (2) Stanford University, Environmental Earth System Science, Stanford, CA, USA, (3) Massachusetts Institute of Technology, Civil and Environmental Engineering, Cambridge, MA, USA, (4) National Aeronautics and Space Administration/Goddard Space Flight Center, Greenbelt, MD, USA. Previous studies of global land-atmosphere hotspots have often relied solely on data from global models with the consequence that they are sensitive to model error. On the other hand, by only analyzing observations, it can be difficult to distinguish causality from mere correlation. In this study, we present a general framework for investigating land-atmosphere interactions using Granger Causality analysis applied to remote sensing data. Based on the near linear relationship between chlorophyll sun induced fluorescence (SIF) and photosynthesis (and thus its relationship with transpiration), we use the GOME-2 fluorescence direct measurements to quantify the surface fluxes between the land and atmosphere. By using SIF data to represent the flux, we bypass the need to use soil moisture data from FLUXNET (limited spatially and temporally) or remote sensing (limited by spatial resolution, canopy interference, measurement depth, and radio frequency interference) thus eliminating additional uncertainty. The Granger Causality analysis allows for the determination of the strength of the two-way causal relationship between SIF and several climatic variables: precipitation, radiation and temperature. We determine that warm regions transitioning from water to energy limitation exhibit strong feedbacks between the land surface and atmosphere due to their high sensitivity to climate and weather variability. Tropical rainforest regions show low magnitudes of causal feedback likely due to other factors influencing the land surface such as phenological controls (e.g. leaf area index), nutrient limitations or soil texture. These results were then compared to CMIP5 GCM results using GPP in place of SIF. GCM results varied greatly between models as well as with the observational data analysis indicating deficiencies in the representation of certain modeled phenomena such as low level clouds and boundary layer development. This study highlights the need for GCM improvement to more accurately capture the feedbacks between the land and atmosphere. These results have the potential to improve our understanding of the underlying mechanisms between land and atmosphere coupling, which could ultimately be used to improve weather and climate predictions.

2012 Aspen Winter Conferences on High Energy and Astrophysics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Campbell, John; Olivier, Dore; Fox, Patrick

Aspen Center for Physics Project Summary DE-SC0007313 Budget Period: 1/1/2012 to 12/31/2012 The Hunt for New Particles, from the Alps to the Plains to the Rockies The 2012 Aspen Winter Conference on Particle Physics was held at the Aspen Center for Physics from February 11 to February 17, 2012. Sixty-seven participants from nine countries, and several universities and national labs attended the workshop titled, The Hunt for New Particles, from the Alps to the Plains to the Rockies. There were 53 formal talks, and a considerable number of informal discussions held during the week. The weeks events included a publicmore » lecture-Hunting the Dark Universe given by Neal Weiner from New York University) and attended by 237 members of the public, and a physics cafe geared for high schoolers that is a discussion with physicists conducted by Spencer Chang (University of Oregon), Matthew Reece (Harvard University) and Julia Shelton (Yale University) and attended by 67 locals and visitors. While there were no published proceedings, some of the talks are posted online and can be Googled. The workshop was organized by John Campbell (Fermilab), Patrick Fox (Fermilab), Ivan Furic (University of Florida), Eva Halkiadakis (Rutgers University) and Daniel Whiteson (University of California Irvine). Additional information is available at http://indico.cern.ch/conferenceDisplay.py?confId=143360. Inflationary Theory and its Confrontation with Data in the Planck Era The 2012 Aspen Winter Conference on Astroparticle physics held at the Aspen Center for Physics was Inflationary Theory and its Confrontation with Data in the Planck Era. It was held from January 30 to February 4, 2012. The 62 participants came from 7 countries and attended 43 talks over five days. Late mornings through the afternoon are reserved for informal discussions. In feedback received from participants, it is often these unplanned chats that produce the most excitement due to working through problems with fellow physicists from other institutions and countries or due to incipient collaborations. In addition, Shamit Kachru of Stanford University gave a public lecture titled The Small (and Large) Scale Structure of Space-Time.There were 237 members of the general public in attendance. Before the lecture, 65 people attended the physics cafe to discuss the current topic with Matthew Kleban (New York University) and Chao-Lin Kuo (Stanford University). This workshop was organized by Olivier Dore (Jet Propulsion Lab), Fabian Schmidt (Caltech), Leonardo Senatore (Stanford University), and Kendrick Smith (Princeton University).« less

PatientVOICE: Development of a Preparatory, Pre-Chemotherapy Online Communication Tool for Older Patients With Cancer.

PubMed

van Dulmen, Sandra; Driesenaar, Jeanine A; van Weert, Julia Cm; van Osch, Mara; Noordman, Janneke

2017-05-10

Good communication around cancer treatment is essential in helping patients cope with their disease and related care, especially when this information is tailored to one's needs. Despite its importance, communication is often complex, in particular in older patients (aged 65 years or older). In addition to the age-related deterioration in information and memory processing older patients experience, communication is also complicated by their required yet often unmet role of being an active, participatory patient. Older patients rarely express their informational needs and their contributions to consultations are often limited. Therefore, older patients with cancer need to be prepared to participate more actively in their care and treatment. The objective of this paper was to report the development of PatientVOICE, an online, preparatory tool with audio facility aimed to enhance the participation of older patients during educational nursing encounters preceding chemotherapy and to improve their information recall. PatientVOICE was developed by applying the following 6 steps of the intervention mapping framework that involved both patients and nurses: (1) needs assessment, (2) specifying determinants and change objectives, (3) reviewing and selecting theoretical methods and practical strategies, (4) developing intervention components, (5) designing adoption and implementation, and (6) making an evaluation plan. A careful execution of these consecutive steps resulted in the ready-to-use preparatory website. PatientVOICE provides pre-visit information about chemotherapy (ie, medical information, side effects, and recommendations of dealing with side effects), information about the educational nursing visit preceding chemotherapy (ie, aim, structure, and recommendations for preparation), techniques to improve patients' communication skills using a question prompt sheet (QPS) and video-modeling examples showing "best practices", and the opportunity to upload and listen back to an audio recording of a patient's own nursing visit. The development process resulted in PatientVOICE, a multi-component online intervention targeted to older patients with cancer. PatientVOICE contains information about the treatment as well as information about the role of the patient during treatment. Using different methods (QPS and audio facility), we hope to support these patients during their treatment. In the future, the utility and usability of this complex intervention will be evaluated in a group of older patients who receive or have received chemotherapy. ©Sandra van Dulmen, Jeanine A Driesenaar, Julia CM van Weert, Mara van Osch, Janneke Noordman. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 10.05.2017.

Knowledge Engineering Approach to the Geotectonic Discourse

NASA Astrophysics Data System (ADS)

Pshenichny, Cyril

2014-05-01

The intellectual challenge of geotectonics is, and always was, much harder than that of most of the sciences: geotectonics has to say much when there is objectively not too much to say. As the target of study (the genesis of regional and planetary geological structures) is vast and multidisciplinary and is more or less generic for many geological disciplines, its more or less complete description is practically inachievable. Hence, the normal pathway of natural-scientific research - first acquire data, then draw conclusion - unlikely can be the case here. Geotectonics does quite the opposite; its approach is purely abductive: first to suggest a conceptualization (hypothesis) based on some external grounds (either general planetary/cosmic/philosophic/religious considerations, or based on experience gained from research of other structures/regions/planets) and then to acquire data that either support or refute it. In fact, geotectonics defines the context for data acquisition, and hence, the paradigm for the entire body of geology. Being an obvious necessity for a descriptive science, this nevertheless creates a number of threats: • Like any people, scientists like simplicity and unity, and therefore a single geotectonic hypothesis may seem preferable once based on the data available at the moment and oppress other views which may acquire evidence in the future; • As impartial data acquisition is rather a myth than reality even in most of the natural sciences, in a study like geology this process becomes strongly biased by the reigning hypothesis and controlled to supply only supportive evidence; • It becomes collectively agreed that any, or great many, domains of geological knowledge are determined by a geotectonic concept, which is, in turn, offered by a reigning hypothesis (sometimes reclassified as theory) - e.g., exploration geologists must involve the global geotectonic terminology in their technical reports on assessment of mineral or hydrocarbon resources, sessions and conferences are entitled like "Geochemical signatures of postcollisional magmas" thus assuming that the concept of collision (i) has been proven to reflect the reality and (ii) surely has something to do with geochemistry of rocks; tectonic terminology becomes a ubiquitous language with no warranty of its correctness and appropriateness to the case. These issues fall into the scope of the field defined as reasoning research in the geosciences (Pshenichny, 2002; 2003). One of its main tools is knowledge engineering (Feigenbaum, 1984). As has been suggested by Anokhin and Longhinos (2013), knowledge engineering, especially its dynamic part being rapidly evolving now, may offer remedies to handle the abovementioned problems. The following solutions will be reported: • Development of an integrated geotectonic context and language shared by the community that follow contrasting geotectonic views; making concepts more or less inter-hypothesis; studying the "anatomy and physiology" of geotectonic hypotheses and fixing the points of concordance, compatibility and disagreement, computation of logical probabilities of the views given a number of hypotheses (Pshenichny, 2004); • Constructing the ontologies, conceptual graphs and event bushes for data acquisition to impartially define the semantics of data and data provenance in geology; • Building the ensembles of event bushes for related domains of geological knowledge (petrology, volcanology, sedimentology and others) to track the actual influence of geotectonic concepts and views on the geo-knowledge. Following these lines of research would create a better environment for flourishing of scientific thought in geology and makes it more efficient and operative in responding to its traditional tasks (impartial geological mapping, mineral and hydrocarbon exploration, geological education and knowledge transfer) and challenges of nowadays such as natural hazard assessment, sustainable regional development, and so forth. Moreover, this would make a significant contribution to creation of a knowledge-based society that is seen as one of the key priorities of Europe and the civilization in general.

Engaging Moms on Teen Indoor Tanning Through Social Media: Protocol of a Randomized Controlled Trial.

PubMed

Pagoto, Sherry L; Baker, Katie; Griffith, Julia; Oleski, Jessica L; Palumbo, Ashley; Walkosz, Barbara J; Hillhouse, Joel; Henry, Kimberly L; Buller, David B

2016-11-29

Indoor tanning elevates the risk for melanoma, which is now the most common cancer in US women aged 25-29. Public policies restricting access to indoor tanning by minors to reduce melanoma morbidity and mortality in teens are emerging. In the United States, the most common policy restricting indoor tanning in minors involves parents providing either written or in person consent for the minor to purchase a tanning visit. The effectiveness of this policy relies on parents being properly educated about the harms of indoor tanning to their children. This randomized controlled trial will test the efficacy of a Facebook-delivered health communication intervention targeting mothers of teenage girls. The intervention will use health communication and behavioral modification strategies to reduce mothers' permissiveness regarding their teenage daughters' use of indoor tanning relative to an attention-control condition with the ultimate goal of reducing indoor tanning in both daughters and mothers. The study is a 12-month randomized controlled trial comparing 2 conditions: an attention control Facebook private group where content will be relevant to teen health with 25% focused on prescription drug abuse, a topic unrelated to tanning; and the intervention condition will enter participants into a Facebook private group where 25% of the teen health content will be focused on indoor tanning. A cohort of 2000 mother-teen daughter dyads will be recruited to participate in this study. Only mothers will participate in the Facebook groups. Both mothers and daughters will complete measures at baseline, end of intervention (1-year) and 6 months post-intervention. Primary outcomes include mothers' permissiveness regarding their teenage daughters' use of indoor tanning, teenage daughters' perception of their mothers' permissiveness, and indoor tanning by both mothers and daughters. The first dyad was enrolled on March 31, 2016, and we anticipate completing this study by October 2019. This trial will deliver social media content grounded in theory and will test it in a randomized design with state-of-the-art measures. This will contribute much needed insights on how to employ social media for health behavior change and disease prevention both for indoor tanning and other health risk behaviors and inform future social media efforts by public health and health care organizations. Clinicaltrials.gov NCT02835807; https://clinicaltrials.gov/ct2/show/NCT02835807 (Archived by WebCite at http://www.webcitation.org/6mDMICcCE). ©Sherry L Pagoto, Katie Baker, Julia Griffith, Jessica L Oleski, Ashley Palumbo, Barbara J Walkosz, Joel Hillhouse, Kimberly L Henry, David B Buller. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 29.11.2016.

Expert Consensus Survey on Digital Health Tools for Patients With Serious Mental Illness: Optimizing for User Characteristics and User Support.

PubMed

Hatch, Ainslie; Hoffman, Julia E; Ross, Ruth; Docherty, John P

2018-06-12

Digital technology is increasingly being used to enhance health care in various areas of medicine. In the area of serious mental illness, it is important to understand the special characteristics of target users that may influence motivation and competence to use digital health tools, as well as the resources and training necessary for these patients to facilitate the use of this technology. The aim of this study was to conduct a quantitative expert consensus survey to identify key characteristics of target users (patients and health care professionals), barriers and facilitators for appropriate use, and resources needed to optimize the use of digital health tools in patients with serious mental illness. A panel of 40 experts in digital behavioral health who met the participation criteria completed a 19-question survey, rating predefined responses on a 9-point Likert scale. Consensus was determined using a chi-square test of score distributions across three ranges (1-3, 4-6, 7-9). Categorical ratings of first, second, or third line were designated based on the lowest category into which the CI of the mean ratings fell, with a boundary >6.5 for first line. Here, we report experts' responses to nine questions (265 options) that focused on (1) user characteristics that would promote or hinder the use of digital health tools, (2) potential benefits or motivators and barriers or unintended consequences of digital health tool use, and (3) support and training for patients and health care professionals. Among patient characteristics most likely to promote use of digital health tools, experts endorsed interest in using state-of-the-art technology, availability of necessary resources, good occupational functioning, and perception of the tool as beneficial. Certain disease-associated signs and symptoms (eg, more severe symptoms, substance abuse problems, and a chaotic living situation) were considered likely to make it difficult for patients to use digital health tools. Enthusiasm among health care professionals for digital health tools and availability of staff and equipment to support their use were identified as variables to enable health care professionals to successfully incorporate digital health tools into their practices. The experts identified a number of potential benefits of and barriers to use of digital health tools by patients and health care professionals. Experts agreed that both health care professionals and patients would need to be trained in the use of these new technologies. These results provide guidance to the mental health field on how to optimize the development and deployment of digital health tools for patients with serious mental illness. ©Ainslie Hatch, Julia E Hoffman, Ruth Ross, John P Docherty. Originally published in JMIR Mental Health (http://mental.jmir.org), 12.06.2018.

Preface: phys. stat. sol. (a) 203/12

NASA Astrophysics Data System (ADS)

Jackman, Richard B.; Nesládek, Milo; Haenen, Ken

2006-09-01

The 30 papers gathered in this issue of physica status solidi (a) give a thorough overview over different topics that were presented during the 11th edition of the International Workshop on Surface and Bulk Defects in CVD Diamond Films (SBDD), which took place from 22 to 24 February 2006, at the Hasselt University in Diepenbeek-Hasselt, Belgium. Since its start more than 10 years ago, the SBDD Workshop has grown into a well-established, yearly early bird meeting place, addressing new emerging science related to the progress in the CVD diamond field. The 10 invited lectures, 29 contributed oral presentations and 26 posters were presented in several sessions during an intense two and a half day long meeting.The number of participants reached 115 this year with participants coming from fifteen countries: Austria, Belgium, Czech Republic, France, Germany, Israel, Italy, Japan, Mexico, Poland, Russia, Singapore, Slovak Republic, Sweden, UK, and USA. The mixture of young and established scientists, including a great proportion of students, made this meeting a hot spot of lively discussions on a wide range of scientific subjects, not only during the meeting itself, but also at several occasions throughout many social events offered by the hospitality of the city of Hasselt.It stands for itself that the workshop would not have been possible without the support of many people and institutions. For financial aid we are especially indebted to the Scientific Research Community Surface Modification of Materials of the F.W.O.-Vlaanderen (Belgium), whose incessant support plays an important role in keeping this meeting going. We also thank the Hasselt University for offering the lecture hall and infrastructure facilities and Seki Technotron Corp. for sponsoring the poster reception and their presence with a table top exhibit. Finally we highly appreciate the active approach of the editorial staff of physica status solidi in this conference and would like to thank most notably Stefan Hildebrandt, Ron Schulz-Rheinländer, Christoph Lellig, and Julia Hübner, for their excellent and patient work, bringing the number of successfully published proceedings of SBDD in pss (a) up to 8 already!To finish, we would all like to invite you to the 12th edition of the SBDD series, newly renamed as Hasselt Diamond Workshop, to be held at its established location of Diepenbeek-Hasselt. We look forward meeting you again at SBDD XII in 2007:Hasselt Diamond Workshop - SBDD XII28 February-2 March 2007Hasselt University, Diepenbeek-Hasselt, Belgiumhttp://www.imo.uhasselt.be/SBDD2007London, Paris, Hasselt, August 2006

EDITORIAL: Nonlinear optical manipulation, patterning and control in nano- and micro-scale systems Nonlinear optical manipulation, patterning and control in nano- and micro-scale systems

NASA Astrophysics Data System (ADS)

Denz, Cornelia; Simoni, Francesco

2009-03-01

Nonlinearities are becoming more and more important for a variety of applications in nanosciences, bio-medical sciences, information processing and photonics. For applications at the crossings of these fields, especially microscopic and nanoscopic imaging and manipulation, nonlinearities play a key role. They may range from simple nonlinear parameter changes up to applications in manipulating, controlling and structuring material by light, or the manipulation of light by light itself. It is this area between basic nonlinear optics and photonic applications that includes `hot' topics such as ultra-resolution optical microscopy, micro- and nanomanipulation and -structuring, or nanophotonics. This special issue contains contributions in this field, many of them from the International Conference on Nonlinear Microscopy and Optical Control held in conjunction with a network meeting of the ESF COST action MP0604 `Optical Micromanipulation by Nonlinear Nanophotonics', 19-22 February 2008, Münster, Germany. Throughout this special issue, basic investigations of material structuring by nonlinear light--matter interaction, light-induced control of nanoparticles, and novel nonlinear material investigation techniques, are presented, covering the basic field of optical manipulation and control. These papers are followed by impressive developments of optical tweezers. Nowadays, optical phase contrast tweezers, twin and especially multiple beam traps, develop particle control in a new dimension: particles can be arranged, sorted and identified with high throughput. One of the most prominent forthcoming applications of optical tweezers is in the field of microfluidics. The action of light on fluids will open new horizons in microfluidic manipulation and control. The field of optical manipulation and control is a very broad field that has developed in an impressive way, in a short time, in Europe with the installation of the MP0604 network. Top researchers from 19 countries are collaborating in this network. The editors are grateful for the active participation of all colleagues in this network, in the network meeting, and in making this special issue a success. We also extend our thanks to a great Journal of Optics A staff that have supported the editing of this special issue, especially the Publishing Editor, Julia Dickinson. Among the active colleagues in our network was also Associate Professor Erik Fällman, Umea University, Sweden. It was with great sadness that we learnt of the death of our colleague and friend in June 2008. We dedicate this special issue to his memory, and the active and always engaged contribution he made both to our conference and to the field of optical micromanipulation and optical control. Erik will be particularly remembered for his applications of optical force measurements on bacterial pili adhesion, which has stimulated a worldwide experimental and theoretical interest in this field.

Effects of Video Game Training on Behavioral and Electrophysiological Measures of Attention and Memory: Protocol for a Randomized Controlled Trial.

PubMed

Ballesteros, Soledad; Mayas, Julia; Ruiz-Marquez, Eloisa; Prieto, Antonio; Toril, Pilar; Ponce de Leon, Laura; de Ceballos, Maria L; Reales Avilés, José Manuel

2017-01-24

Neuroplasticity-based approaches seem to offer promising ways of maintaining cognitive health in older adults and postponing the onset of cognitive decline symptoms. Although previous research suggests that training can produce transfer effects, this study was designed to overcome some limitations of previous studies by incorporating an active control group and the assessment of training expectations. The main objectives of this study are (1) to evaluate the effects of a randomized computer-based intervention consisting of training older adults with nonaction video games on brain and cognitive functions that decline with age, including attention and spatial working memory, using behavioral measures and electrophysiological recordings (event-related potentials [ERPs]) just after training and after a 6-month no-contact period; (2) to explore whether motivation, engagement, or expectations might account for possible training-related improvements; and (3) to examine whether inflammatory mechanisms assessed with noninvasive measurement of C-reactive protein in saliva impair cognitive training-induced effects. A better understanding of these mechanisms could elucidate pathways that could be targeted in the future by either behavioral or neuropsychological interventions. A single-blinded randomized controlled trial with an experimental group and an active control group, pretest, posttest, and 6-month follow-up repeated measures design is used in this study. A total of 75 cognitively healthy older adults were randomly distributed into experimental and active control groups. Participants in the experimental group received 16 1-hour training sessions with cognitive nonaction video games selected from Lumosity, a commercial brain training package. The active control group received the same number of training sessions with The Sims and SimCity, a simulation strategy game. We have recruited participants, have conducted the training protocol and pretest assessments, and are currently conducting posttest evaluations. The study will conclude in the first semester of 2017. Data analysis will take place during 2017. The primary outcome is transfer of benefit from training to attention and working memory functions and the neural mechanisms underlying possible cognitive improvements. We expect that mental stimulation with video games will improve attention and memory both at the behavioral level and in ERP components promoting brain and mental health and extending independence among elderly people by avoiding the negative personal and economic consequences of long-term care. Clinicaltrials.gov NCT02796508; https://clinicaltrials.gov/ct2/show/NCT02796508 (archived by WebCite at http://www.webcitation.org/6nFeKeFNB). ©Soledad Ballesteros, Julia Mayas, Eloisa Ruiz-Marquez, Antonio Prieto, Pilar Toril, Laura Ponce de Leon, Maria L de Ceballos, José Manuel Reales Avilés. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 24.01.2017.

A taxonomic monograph of the genus Dodomeira Bellò & Baviera,  a new genus of Peritelini from Sicily (Coleoptera: Curculionidae: Entiminae).

PubMed

Bello, Cesare; Osella, Giuseppe; Baviera, Cosimo

2017-10-13

The genus Dodomeira Bellò & Baviera gen. n. of the tribe Peritelini Lacordaire (1863) (Curculionidae: Entiminae) which includes 39 species is described. Seven species are transferred from Pseudomeira Stierlin, 1881: Dodomeira confusa (Pierotti, 2012) comb. n., Dodomeira exigua (Stierlin, 1861) comb. n., Dodomeira ficuzzensis (Bellò & Baviera, 2011) comb. n., Dodomeira himerensis (Bellò & Baviera, 2011) comb. n., Dodomeira petrensis (Bellò & Baviera, 2011) comb. n., Dodomeira pfisteri (Stierlin, 1864) comb. n., Dodomeira trinacriae (Bellò & Baviera, 2011) comb. n.. Thirty-two species are new for science and here described: Dodomeira adrianae Bellò & Baviera sp. n., Dodomeira alta Bellò & Baviera sp. n., Dodomeira angelae Bellò & Baviera sp. n., Dodomeira asinelliensis Bellò & Baviera sp. n., Dodomeira belicensis Bellò & Baviera sp. n., Dodomeira bertoni Bellò & Baviera sp. n., Dodomeira calatina Bellò & Baviera sp. n., Dodomeira caoduroi Bellò & Baviera sp. n. n., Dodomeira elima Bellò & Baviera sp. n., Dodomeira enzoi Bellò & Baviera sp. n., Dodomeira fossor Bellò & Baviera sp. n., Dodomeira forbicionii Bellò & Baviera sp. n., Dodomeira genistae Bellò & Baviera sp. n., Dodomeira giustoi Bellò & Baviera sp. n., Dodomeira hiemalis Bellò & Baviera sp. n., Dodomeira ibleiensis Bellò & Baviera sp. n., Dodomeira illuminatae Bellò & Baviera sp. n., Dodomeira juliae Bellò & Baviera sp. n., Dodomeira laliaensis Bellò & Baviera sp. n., Dodomeira magrinii Bellò & Baviera sp. n., Dodomeira montivaga Bellò & Baviera sp. n., Dodomeira margheritae Bellò & Baviera sp. n., Dodomeira maritimaensis Bellò & Baviera sp. n., Dodomeira nobilis Bellò & Baviera sp. n., Dodomeira paladinii Bellò & Baviera sp. n., Dodomeira sabellai Bellò & Baviera sp. n., Dodomeira saccoi Bellò & Baviera sp. n., Dodomeira sicana Bellò & Baviera sp. n., Dodomeira sicelidis Bellò & Baviera sp. n., Dodomeira siderea Bellò & Baviera sp. n., Dodomeira silvanae Bellò & Baviera sp. n., Dodomeira zingara Bellò & Baviera sp. n.. In addition, according to morphological characters, eight informal groups of species are established (the number of species ascribed to the group is in brackets): Dodomeira adrianae species group (13), Dodomeira caoduroi species group (2), Dodomeira exigua species group (5), Dodomeira ficuzzensis species group (2), Dodomeira maritimaensis species group (1), Dodomeira petrensis species group (2), Dodomeira pfisteri species group (13), Dodomeira saccoi species group (1). We present a key for the identification of the new genus among Palaearctic Peritelini, one for single species groups and an other for each species. A checklist of all the species currently known of Dodomeira gen. n. and Pseudomeira Stierlin (1881), with distribution maps and data on ecology and phenology of all the species of Dodomeira gen. n. are also provided.

Chemical Achievers: The Human Face of the Chemical Sciences (by Mary Ellen Bowden)

NASA Astrophysics Data System (ADS)

Kauffman, George B.

1999-02-01

Chemical Heritage Foundation: Philadelphia, PA, 1997. viii + 180 pp. 21.6 x 27.8 cm. ISBN 0-941901-15-1. Paper. 20.00 (10.00 for high school teachers who provide documentation). At a 1991 summer workshop sponsored by the Chemical Heritage Foundation and taught by Derek A. Davenport and William B. Jensen, high school and college teachers of introductory chemistry requested a source of pictorial material about famous chemical scientists suitable as a classroom aid. CHF responded by publishing this attractive, inexpensive paperback volume, which reflects the considerable research effort needed to locate appropriate images and to write the biographical essays. Printed on heavy, glossy paper and spiral bound to facilitate conversion to overhead transparencies, it contains 157 images from pictorial collections at CHF and many other institutions on two types of achievers: the historical "greats" most often referred to in introductory courses, and scientists who made contributions in areas of the chemical sciences that are of special relevance to modern life and the career choices students will make. The pictures are intended to provide the "human face" of the book's subtitle- "to point to the human beings who had the insights and made the major advances that [teachers] ask students to master." Thus, for example, Boyle's law becomes less cold and abstract if the student can connect it with the two portraits of the Irish scientist even if his face is topped with a wig. Marie Curie can be seen in the role of wife and mother as well as genius scientist in the photographs of her with her two daughters, one of whom also became a Nobel laureate. And students are reminded of the ubiquity of the contribution of the chemical scientists to all aspects of our everyday life by the stories and pictures of Wallace Hume Carothers' path to nylon, Percy Lavon Julian's work on hormones, and Charles F. Chandler and Rachel Carson's efforts to preserve the environment. In addition to portraits (formal and informal, familiar and unfamiliar), caricatures, apparatus, patent drawings, models, manuscripts, memoranda, laboratories, and plants and buildings are featured. The book presents many images of chemists in the work settings where they actually made their discoveries. The quaint pictures of Chandler with his wash bottle, William H. Walker with his slide rule, Carl Djerassi peering at a flask without goggle protection, and Edward Goodrich Acheson with his omnipresent cigar evoke a bygone era that will induce nostalgia in instructors and curiosity or disbelief in students. Many of the 80 featured chemists are minority scientists; 10 are women (Dorothy Crowfoot Hodgkin, Marie Curie, Iréne Joliot-Curie, Mme. Lavoisier, Rosalind Franklin, Stephanie L. Kwolek, Ellen Swallow Richards, Alice Hamilton, Rachel Carson, and Julia Brainerd Hall, whose role in her brother Charles Martin Hall's development of the electrolytic production of metal is underappreciated), and three are African-Americans (Percy Lavon Julian, Walter Lincoln Hawkins, and Henry Aaron Hill). The book's 11 sections, each prefaced with a short, helpful summary, and the number of scientists profiled in each are Forerunners, 4; Theory and Production of Gases, 4; Electrochemistry and Electrochemical Industries, 12; The Path to the Periodic Table, 9; Atomic and Nuclear Structure, 9; Chemical Synthesis, Structure, and Bonding, 9; Pharmaceuticals and the Path to Biomolecules, 10; Petroleum and Petrochemicals, 4; Plastics and Other Polymers, 6; Chemical Engineering (most of whose practitioners were unfamiliar to me), 6; and Human and Natural Environmental Concerns, 7. An extensive bibliography (five double-column pages), arranged according to these sections, includes books, articles, dissertations, collections, and oral histories. Items as recent as 1997 and even a 1998 book in press are cited. An index (three triple-column pages) facilitates location of material. Chemical Achievers is to some extent similar to Henry Monmouth Smith's long-out-of-print Torchbearers of Chemistry (Academic Press, 1949), but the quality of the illustrations and paper are much better and the text is much more detailed. The book is virtually error-free; the only one that I spotted was the misspelling of O. Bertrand Ramsay's name as Ramsey.

EDITORIAL: Wind energy

NASA Astrophysics Data System (ADS)

Mann, Jakob; Nørkær Sørensen, Jens; Morthorst, Poul-Erik

2008-01-01

Wind energy is rapidly growing. In 2006 the installed generating capacity in the world increased by 25%, a growth rate which has more or less been sustained during the last decade. And there is no reason to believe that this growth will slow significantly in the coming years. For example, the United Kingdom's goal for installed wind turbines by 2020 is 33 GW up from 2 GW in 2006, an average annual growth rate of 22% over that period. More than half of all turbines are installed in Europe, but United States, India and lately China are also rapidly growing markets. The cradle of modern wind energy was set by innovative blacksmiths in rural Denmark. Now the wind provides more than 20% of the electrical power in Denmark, the industry has professionalized and has close ties with public research at universities. This focus issue is concerned with research in wind energy. The main purposes of research in wind energy are to: decrease the cost of power generated by the wind; increase the reliability and predictability of the energy source; investigate and reduce the adverse environmental impact of massive deployment of wind turbines; build research based educations for wind energy engineers. This focus issue contains contributions from several fields of research. Decreased costs cover a very wide range of activities from aerodynamics of the wind turbine blades, optimal site selection for the turbines, optimization of the electrical grid and power market for a fluctuating source, more efficient electrical generators and gears, and new materials and production techniques for turbine manufacturing. The United Kingdom recently started the construction of the London Array, a 1 GW off-shore wind farm east of London consisting of several hundred turbines. To design such a farm optimally it is necessary to understand the chaotic and very turbulent flow downwind from a turbine, which decreases the power production and increases the mechanical loads on other nearby turbines. Also addressed within the issue is how much conventional power production can be replaced by the ceaseless wind, with the question of how Greece's target of 29% renewables by 2020 is to be met efficiently. Other topics include an innovative way to determine the power curve of a turbine experimentally more accurately, the use of fluid dynamics tools to investigate the implications of placing vortex generators on wind turbine blades (thereby possibly improving their efficiency) and a study of the perception of wind turbine noise. It turns out that a small but significant fraction of wind turbine neighbours feel that turbine generated noise impairs their ability to rest. The annoyance is correlated with a negative attitude towards the visual impact on the landscape, but what is cause and effect is too early to say. As mentioned there is a rush for wind turbines in many countries. However, this positive development for the global climate is currently limited by practical barriers. One bottleneck is the difficulties for the sub-suppliers of gears and other parts to meet the demand. Another is the difficulties to meet the demand for engineers specialized in wind. For that reason the Technical University of Denmark (DTU) recently launched the world's first Wind Energy Masters Program. Here and elsewhere in the world of wind education and research we should really speed up now, as our chances of contributing to emission free energy production and a healthier global climate have never been better. Focus on Wind Energy Contents The articles below represent the first accepted contributions and further additions will appear in the near future. Wind turbines—low level noise sources interfering with restoration? Eja Pedersen and Kerstin Persson Waye On the effect of spatial dispersion of wind power plants on the wind energy capacity credit in Greece George Caralis, Yiannis Perivolaris, Konstantinos Rados and Arthouros Zervos Large-eddy simulation of spectral coherence in a wind turbine wake A Jimenez, A Crespo, E Migoya and J Garcia How to improve the estimation of power curves for wind turbines Julia Gottschall and Joachim Peinke

Reliability and Validity of the Telephone-Based eHealth Literacy Scale Among Older Adults: Cross-Sectional Survey.

PubMed

Stellefson, Michael; Paige, Samantha R; Tennant, Bethany; Alber, Julia M; Chaney, Beth H; Chaney, Don; Grossman, Suzanne

2017-10-26

Only a handful of studies have examined reliability and validity evidence of scores produced by the 8-item eHealth literacy Scale (eHEALS) among older adults. Older adults are generally more comfortable responding to survey items when asked by a real person rather than by completing self-administered paper-and-pencil or online questionnaires. However, no studies have explored the psychometrics of this scale when administered to older adults over the telephone. The objective of our study was to examine the reliability and internal structure of eHEALS data collected from older adults aged 50 years or older responding to items over the telephone. Respondents (N=283) completed eHEALS as part of a cross-sectional landline telephone survey. Exploratory structural equation modeling (E-SEM) analyses examined model fit of eHEALS scores with 1-, 2-, and 3-factor structures. Subsequent analyses based on the partial credit model explored the internal structure of eHEALS data. Compared with 1- and 2-factor models, the 3-factor eHEALS structure showed the best global E-SEM model fit indices (root mean square error of approximation=.07; comparative fit index=1.0; Tucker-Lewis index=1.0). Nonetheless, the 3 factors were highly correlated (r range .36 to .65). Item analyses revealed that eHEALS items 2 through 5 were overfit to a minor degree (mean square infit/outfit values <1.0; t statistics less than -2.0), but the internal structure of Likert scale response options functioned as expected. Overfitting eHEALS items (2-5) displayed a similar degree of information for respondents at similar points on the latent continuum. Test information curves suggested that eHEALS may capture more information about older adults at the higher end of the latent continuum (ie, those with high eHealth literacy) than at the lower end of the continuum (ie, those with low eHealth literacy). Item reliability (value=.92) and item separation (value=11.31) estimates indicated that eHEALS responses were reliable and stable. Results support administering eHEALS over the telephone when surveying older adults regarding their use of the Internet for health information. eHEALS scores best captured 3 factors (or subscales) to measure eHealth literacy in older adults; however, statistically significant correlations between these 3 factors suggest an overarching unidimensional structure with 3 underlying dimensions. As older adults continue to use the Internet more frequently to find and evaluate health information, it will be important to consider modifying the original eHEALS to adequately measure societal shifts in online health information seeking among aging populations. ©Michael Stellefson, Samantha R Paige, Bethany Tennant, Julia M Alber, Beth H Chaney, Don Chaney, Suzanne Grossman. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 26.10.2017.

Views of Community Managers on Knowledge Co-creation in Online Communities for People With Disabilities: Qualitative Study.

PubMed

Amann, Julia; Rubinelli, Sara

2017-10-10

The use of online communities to promote end user involvement and co-creation in the product and service innovation process is well documented in the marketing and management literature. Whereas online communities are widely used for health care service provision and peer-to-peer support, only little is known about how they could be integrated into the health care innovation process. The overall objective of this qualitative study was to explore community managers' views on and experiences with knowledge co-creation in online communities for people with disabilities. A descriptive qualitative research design was used. Data were collected through semi-structured interviews with nine community managers. To complement the interview data, additional information was retrieved from the communities in the form of structural information (number of registered users, number and names of topic areas covered by the forum) and administrative information (terms and conditions and privacy statements, forum rules). Data were analyzed using thematic analysis. Our results highlight two main aspects: peer-to-peer knowledge co-creation and types of collaboration with external actors. Although community managers strongly encouraged peer-to-peer knowledge co-creation, our findings indicated that these activities were not common practice in the communities under investigation. In fact, much of what related to co-creation, prototyping, and product development was still perceived to be directed by professionals and experts. Community managers described the role of their respective communities as informing this process rather than a driving force. The role of community members as advisors to researchers, health care professionals, and businesses was discussed in the context of types of collaboration with external actors. According to the community managers, most of the external inquiries related to research projects of students or health care professionals in training, who often joined a community for the sole purpose of recruiting participants for their research. Despite this unilateral form of knowledge co-creation, community managers acknowledged the mere interest of these user groups as beneficial, as long as their interest was not purely financially motivated. Being able to contribute to advancing research, improving products, and informing the planning and design of health care services were described as some of the key motivations to engage with external stakeholders. This paper draws attention to the currently under-investigated role of online communities as platforms for collaboration and co-creation between patients, health care professionals, researchers, and businesses. It describes community managers' views on and experiences with knowledge co-creation and provides recommendations on how these activities can be leveraged to foster knowledge co-creation in health care. Engaging in knowledge co-creation with online health communities may ultimately help to inform the planning and design of products, services, and research activities that better meet the actual needs of those living with a disability. ©Julia Amann, Sara Rubinelli. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 10.10.2017.

Clarifying the Concept of Adherence to eHealth Technology: Systematic Review on When Usage Becomes Adherence.

PubMed

Sieverink, Floor; Kelders, Saskia M; van Gemert-Pijnen, Julia Ewc

2017-12-06

In electronic health (eHealth) evaluations, there is increasing attention for studying the actual usage of a technology in relation to the outcomes found, often by studying the adherence to the technology. On the basis of the definition of adherence, we suggest that the following three elements are necessary to determine adherence to eHealth technology: (1) the ability to measure the usage behavior of individuals; (2) an operationalization of intended use; and (3) an empirical, theoretical, or rational justification of the intended use. However, to date, little is known on how to operationalize the intended usage of and the adherence to different types of eHealth technology. The study aimed to improve eHealth evaluations by gaining insight into when, how, and by whom the concept of adherence has been used in previous eHealth evaluations and finding a concise way to operationalize adherence to and intended use of different eHealth technologies. A systematic review of eHealth evaluations was conducted to gain insight into how the use of the technology was measured, how adherence to different types of technologies was operationalized, and if and how the intended use of the technology was justified. Differences in variables between the use of the technology and the operationalization of adherence were calculated using a chi-square test of independence. In total, 62 studies were included in this review. In 34 studies, adherence was operationalized as "the more use, the better," whereas 28 studies described a threshold for intended use of the technology as well. Out of these 28, only 6 reported a justification for the intended use. The proportion of evaluations of mental health technologies reporting a justified operationalization of intended use is lagging behind compared with evaluations of lifestyle and chronic care technologies. The results indicated that a justification of intended use does not require extra measurements to determine adherence to the technology. The results of this review showed that to date, justifications for intended use are often missing in evaluations of adherence. Evidently, it is not always possible to estimate the intended use of a technology. However, such measures do not meet the definition of adherence and should therefore be referred to as the actual usage of the technology. Therefore, it can be concluded that adherence to eHealth technology is an underdeveloped and often improperly used concept in the existing body of literature. When defining the intended use of a technology and selecting valid measures for adherence, the goal or the assumed working mechanisms should be leading. Adherence can then be standardized, which will improve the comparison of adherence rates to different technologies with the same goal and will provide insight into how adherence to different elements contributed to the outcomes. ©Floor Sieverink, Saskia M Kelders, Julia EWC van Gemert-Pijnen. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 06.12.2017.

Quantum Field Theory in Curved Spacetime

NASA Astrophysics Data System (ADS)

Reynolds, Sally C.; Gallagher, Andrew

2012-03-01

List of contributors; Foreword J. T. Francis Thackeray; 1. African genesis: an evolving paradigm Sally C. Reynolds; 2. Academic genealogy Peter Ungar and Phillip V. Tobias; Part I. In Search of Origins: Evolutionary Theory, New Species, and Paths into the Past: 3. Speciation in hominin evolution Colin Groves; 4. Searching for a new paradigm for hominid origins in Chad (Central Africa) Michel Brunet; 5. From hominoid arboreality to hominid bipedalism Brigitte Senut; 6. Orrorin and the African ape/hominid dichotomy Martin Pickford; 7. A brief history and results of 40 years of Sterkfontein excavations Ronald J. Clarke; Part II. Hominin Morphology Through Time: Brains, Bodies and Teeth: 8. Hominin brain evolution, 1925-2011: an emerging overview Dean Falk; 9. The issue of brain reorganisation in Australopithecus and early hominids: Dart had it right Ralph L. Holloway; 10. The mass of the human brain: is it a spandrel? Paul R. Manger, Jason Hemingway, Muhammad Spocter and Andrew Gallagher; 11. Origin and diversity of early hominin bipedalism Henry M. McHenry; 12. Forelimb adaptations in Australopithecus afarensis Michelle S. M. Drapeau; 13. Hominin proximal femur morphology from the Tugen Hills to Flores Brian G. Richmond and William L. Jungers; 14. Daily rates of dentine formation and root extension rates in Paranthropus boisei, KNM-ER 1817, from Koobi Fora, Kenya M. Christopher Dean; 15. On the evolutionary development of early hominid molar teeth and the Gondolin Paranthropus molar Kevin L. Kuykendall; 16. Digital South African fossils: morphological studies using reference-based reconstruction and electronic preparation Gerhard W. Weber, Philipp Gunz, Simon Neubauer, Philipp Mitteroecker and Fred L. Bookstein; Part III. Modern Human Origins: Patterns, and Processes: 17. Body size in African Middle Pleistocene Homo Steven E. Churchill, Lee R. Berger, Adam Hartstone-Rose and Headman Zondo; 18. The African origin of recent humanity Milford H. Wolpoff and Sang-Hee Lee; 19. Assimilation and modern human origins in the African peripheries Fred H. Smith, Vance T. Hutchinson and Ivor Janković; 20. Patterns of Middle Pleistocene hominin evolution in Africa and the emergence of modern humans Emma Mbua and Günter Bräuer; 21. Integration of the genetic, anatomical, and archaeological data for the African origin of modern humans: problems and prospects Osbjorn M. Pearson; Part IV. In Search of Context: Hominin Environments, Behaviour and Lithic Cultures: 22. Animal palaeocommunity variability and habitat preference of robust australopiths in South Africa Darryl J. de Ruiter, Matt Sponheimer and Julia Lee-Thorp; 23. Impacts of environmental change and community ecology on the composition and diversity of the southern African monkey fauna from the Plio-Pleistocene to the present Sarah Elton; 24. African genesis revisited: reflections on Raymond Dart and the 'Predatory Transition from Ape(-Man) to Man' Travis R. Pickering; 25. Shared intention in early artefacts: an exploration of deep structure and implications for communication and language John A. J. Gowlett; 26. Sibudu Cave: recent archaeological work on the Middle Stone Age Lyn Wadley; 27. The oldest burials and their significance Avraham Ronen; Index.

Integrated Care in Prostate Cancer (ICARE-P): Nonrandomized Controlled Feasibility Study of Online Holistic Needs Assessment, Linking the Patient and the Health Care Team.

PubMed

Nanton, Veronica; Appleton, Rebecca; Dale, Jeremy; Roscoe, Julia; Hamborg, Thomas; Ahmedzai, Sam H; Arvanitis, Theodoros N; Badger, Douglas; James, Nicholas; Mendelsohn, Richard; Khan, Omar; Parashar, Deepak; Patel, Prashant

2017-07-28

The potential of technology to aid integration of care delivery systems is being explored in a range of contexts across a variety of conditions in the United Kingdom. Prostate cancer is the most common cancer in UK men. With a 10-year survival rate of 84%, there is a need to explore innovative methods of care that are integrated between primary health care providers and specialist teams in order to address long-term consequences of the disease and its treatment as well as to provide continued monitoring for recurrence. Our aim was to test the feasibility of a randomized controlled trial to compare a model of prostate cancer continuing and follow-up care integration, underpinned by digital technology, with usual care in terms of clinical and cost-effectiveness, patient-reported outcomes, and experience. A first phase of the study has included development of an online adaptive prostate specific Holistic Needs Assessment system (HNA), training for primary care-based nurses, training of an IT peer supporter, and interviews with health care professionals and men with prostate cancer to explore views of their care, experience of technology, and views of the proposed intervention. In Phase 2, men in the intervention arm will complete the HNA at home to help identify and articulate concerns and share them with their health care professionals, in both primary and specialist care. Participants in the control arm will receive usual care. Outcomes including quality of life and well-being, prostate-specific concerns, and patient enablement will be measured 3 times over a 9-month period. Findings from phase 1 indicated strong support for the intervention among men, including those who had had little experience of digital technology. Men expressed a range of views on ways that the online system might be used within a clinical pathway. Health care professionals gave valuable feedback on how the output of the assessment might be presented to encourage engagement and uptake by clinical teams. Recruitment to the second phase of the study, the feasibility trial, commenced March 2017. To our knowledge, this study is the first in the United Kingdom to trial an online holistic needs assessment for men with prostate cancer, with data shared between patients and primary and secondary care providers. This study addresses recommendations in recent policy documents promoting the importance of data sharing and enhanced communication between care providers as a basis for care integration. We anticipate that this model of care will ultimately provide important benefits for both patients and the National Health Service. International Standard Randomized Controlled Trial Number (ISRCTN): 31380482; http://www.isrctn.com/ISRCTN31380482 (Archived by WebCite at http://www.webcitation.org/6s8I42u5N). ©Veronica Nanton, Rebecca Appleton, Jeremy Dale, Julia Roscoe, Thomas Hamborg, Sam H Ahmedzai, Theodoros N Arvanitis, Douglas Badger, Nicholas James, Richard Mendelsohn, Omar Khan, Deepak Parashar, Prashant Patel. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 28.07.2017.

In situ soil moisture and matrix potential - what do we measure?

NASA Astrophysics Data System (ADS)

Jackisch, Conrad; Durner, Wolfgang

2017-04-01

Soil moisture and matric potential are often regarded as state variables that are simple to monitor at the Darcy-scale. At the same time unproven believes about the capabilities and reliabilities of specific sensing methods or sensor systems exist. A consortium of ten institutions conducted a comparison study of currently available sensors for soil moisture and matrix potential at a specially homogenised field site with sandy loam soil, which was kept free of vegetation. In total 57 probes of 15 different systems measuring soil moisture, and 50 probes of 14 different systems measuring matric potential have been installed in a 0.5 meter grid to monitor the moisture state in 0.2 meter depth. The results give rise to a series of substantial questions about the state of the art in hydrological monitoring, the heterogeneity problem and the meaning of soil water retention at the field scale: A) For soil moisture, most sensors recorded highly plausible data. However, they do not agree in absolute values and reaction timing. For matric potential, only tensiometers were able to capture the quick reactions during rainfall events. All indirect sensors reacted comparably slowly and thus introduced a bias with respect to the sensing of soil water state under highly dynamic conditions. B) Under natural field conditions, a better homogeneity than in our setup can hardly be realised. While the homogeneity assumption held for the first weeks, it collapsed after a heavy storm event. The event exceeded the infiltration capacity, initiated the generation of redistribution networks at the surface, which altered the local surface properties on a very small scale. If this is the reality at a 40 m2 plot, what representativity have single point observations referencing the state of whole basins? C) A comparison of in situ and lab-measured retention curves marks systematic differences. Given the general practice of soil water retention parameterisation in almost any hydrological model this poses quite some concern about deriving field parameters from lab measurements. We will present some insights from the comparison study and highlight the conceptual concerns arising from it. Through this we hope to stimulate a discussion towards more critical revision of measurement assumptions and towards the development of alternative techniques to monitor subsurface states. The sensor comparison study consortium is a cooperation of Wolfgang Durner2, Ines Andrä2, Kai Germer2, Katrin Schulz2, Marcus Schiedung2, Jaqueline Haller-Jans2, Jonas Schneider2, Julia Jaquemotte2, Philipp Helmer2, Leander Lotz2, Thomas Graeff3, Andreas Bauer3, Irene Hahn3, Conrad Jackisch1, Martin Sanda4, Monika Kumpan5, Johann Dorner5, Gerrit de Rooij6, Stephan Wessel-Bothe7, Lorenz Kottmann8, and Siegfried Schittenhelm8. The great support by the team and the Thünen Institute Braunschweig is gratefully acknowledged. 1 Karlsruhe Institute of Technology, 2 Technical University of Braunschweig, 3 University of Potsdam, 4 Technical University of Prague, 5 Federal Department for Water Management Petzenkirchen, 6 Helmholtz Centre for Environmental Research Halle, 7 ecoTech GmbH Bonn, 8 Julius Kühn Institute Braunschweig

The Role of Web-Based Health Information in Help-Seeking Behavior Prior to a Diagnosis of Lung Cancer: A Mixed-Methods Study.

PubMed

Mueller, Julia; Jay, Caroline; Harper, Simon; Todd, Chris

2017-06-08

Delays to diagnosis in lung cancer can lead to reduced chance of survival, and patients often wait for several months before presenting symptoms. The time between first symptom recognition until diagnosis has been theorized into three intervals: symptom appraisal, help-seeking, and diagnostic interval (here: "pathway to diagnosis"). Interventions are needed to reduce delays to diagnosis in lung cancer. The Web has become an important lay health information source and could potentially play a role in this pathway to diagnosis. Our overall aim was to gain a preliminary insight into whether Web-based information plays a role in the pathway to diagnosis in lung cancer in order to assess whether it may be possible to leverage this information source to reduce delays to diagnosis. Patients diagnosed with lung cancer in the 6 months before study entry completed a survey about whether (and how, if yes) they had used the Web to appraise their condition prior to diagnosis. Based on survey responses, we purposively sampled patients and their next-of-kin for semistructured interviews (24 interviews; 33 participants). Interview data were analyzed qualitatively using Framework Analysis in the context of the pathway to diagnosis model. A total of 113 patients completed the survey (age: mean 67.0, SD 8.8 years). In all, 20.4% (23/113) reported they or next-of-kin had researched their condition online before the diagnosis. The majority of searches (20/23, 87.0%) were conducted by or with the help of next-of-kin. Interview results suggest that patients and next-of-kin perceived an impact of the information found online on all three intervals in the time to diagnosis. In the appraisal interval, participants used online information to evaluate symptoms and possible causes. In the help-seeking interval, the Web was used to inform the decision of whether to present to health services. In the diagnostic interval, it was used to evaluate health care professionals' advice, to support requests for further investigation of symptoms, and to understand medical jargon. Within this interval, we identified two distinct subintervals (before/after relevant diagnostic tests were initiated), in which the Web reportedly played different roles. Because only 20.4% of the sample reported prediagnosis Web searches, it seems the role of the Web before diagnosis of lung cancer is at present still limited, but this proportion is likely to increase in the future, when barriers such as unfamiliarity with technology and unwillingness to be informed about one's own health are likely to decrease. Participants' perceptions suggest that the Web can have an impact on all three intervals in the pathway to diagnosis. Thus, the Web may hold the potential to reduce delays in the diagnostic process, and this should be explored in future research and interventions. Our results also suggest a division of the diagnostic interval into two subintervals may be useful. ©Julia Mueller, Caroline Jay, Simon Harper, Chris Todd. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 08.06.2017.

Approximation Set of the Interval Set in Pawlak's Space

PubMed Central

Wang, Jin; Wang, Guoyin

2014-01-01

The interval set is a special set, which describes uncertainty of an uncertain concept or set Z with its two crisp boundaries named upper-bound set and lower-bound set. In this paper, the concept of similarity degree between two interval sets is defined at first, and then the similarity degrees between an interval set and its two approximations (i.e., upper approximation set R¯(Z) and lower approximation set R_(Z)) are presented, respectively. The disadvantages of using upper-approximation set R¯(Z) or lower-approximation set R_(Z) as approximation sets of the uncertain set (uncertain concept) Z are analyzed, and a new method for looking for a better approximation set of the interval set Z is proposed. The conclusion that the approximation set R 0.5(Z) is an optimal approximation set of interval set Z is drawn and proved successfully. The change rules of R 0.5(Z) with different binary relations are analyzed in detail. Finally, a kind of crisp approximation set of the interval set Z is constructed. We hope this research work will promote the development of both the interval set model and granular computing theory. PMID:25177721

Method And Apparatus For Arbitrarily Large Capacity Removable Media

DOEpatents

Milligan, Charles A.; Hughes, James P.; Debiez; Jacques

2003-04-08

A method and apparatus to handle multiple sets of removable media within a storage system. A first set of removable media are mounted on a set of drives. Data is accepted until the first set of removable media is filled. A second set of removable media is mounted on the drives, while the first set of removable media is removed. When the change in removable media is complete, writing of data proceeds on the second set of removable media. Data may be buffered while the change in removable media occurs. Alternatively, two sets of removable media may be mounted at the same time. When the first set of removable media is filled to a selected amount, the second set of removable media may then be used to write the data. A third set of removable media is set up or mounted for use, while the first set of removable media is removed.

Nonlinear interferometric vibrational imaging

NASA Technical Reports Server (NTRS)

Boppart, Stephen A. (Inventor); Marks, Daniel L. (Inventor)

2009-01-01

A method of examining a sample, which includes: exposing a reference to a first set of electromagnetic radiation, to form a second set of electromagnetic radiation scattered from the reference; exposing a sample to a third set of electromagnetic radiation to form a fourth set of electromagnetic radiation scattered from the sample; and interfering the second set of electromagnetic radiation and the fourth set of electromagnetic radiation. The first set and the third set of electromagnetic radiation are generated from a source; at least a portion of the second set of electromagnetic radiation is of a frequency different from that of the first set of electromagnetic radiation; and at least a portion of the fourth set of electromagnetic radiation is of a frequency different from that of the third set of electromagnetic radiation.

Setting Goals for Achievement in Physical Education Settings

ERIC Educational Resources Information Center

Baghurst, Timothy; Tapps, Tyler; Kensinger, Weston

2015-01-01

Goal setting has been shown to improve student performance, motivation, and task completion in academic settings. Although goal setting is utilized by many education professionals to help students set realistic and proper goals, physical educators may not be using goal setting effectively. Without incorporating all three types of goals and…

Factors Associated With Access to HIV Testing and Primary Care Among Migrants Living in Europe: Cross-Sectional Survey.

PubMed

Fakoya, Ibidun; Álvarez-Del Arco, Débora; Copas, Andrew J; Teixeira, Bryan; Block, Koen; Gennotte, Anne-Francoise; Volny-Anne, Alain; Bil, Janneke P; Touloumi, Giota; Del Amo, Julia; Burns, Fiona M

2017-11-06

There is a heavy and disproportionate burden of human immunodeficiency virus (HIV) infection among migrant communities living in Europe. Despite this, the published evidence related to HIV testing, prevention, and treatment needs for migrants is sparse. The aim of this study was to identify the factors associated with access to primary care and HIV testing among migrant groups living in Europe. A Web-based survey (available in 14 languages) was open to all people aged 18 years and older, living outside their country of birth in the World Health Organization (WHO) European area. Community organizations in 9 countries promoted the survey to migrant groups, focusing on those at a higher risk of HIV (sub-Saharan Africans, Latin Americans, gay or bisexual men, and people who inject drugs). Multivariable analysis examined factors associated with access to primary care and previous history of an HIV test. In total, 559 women, 395 heterosexual men, and 674 gay or bisexual men were included in the analysis, and 68.1% (359/527) of women, 59.5% (220/371) of heterosexual men, and 89.6% (596/664) of gay or bisexual men had tested for HIV. Low perceived risk was the reason given for not testing by 62.3% (43/69) of gay or bisexual men and 83.3% (140/168) of women and heterosexual men who reported never having tested for HIV. Access to primary care was >60% in all groups. Access to primary care was strongly positively associated with living in Northern Europe compared with Southern Europe (women: adjusted odds ratio, aOR 34.56 [95% CI 11.58-101]; heterosexual men: aOR 6.93 [95% CI 2.49-19.35], and gay or bisexual men: aOR 2.53 [95% CI 1.23-5.19]), whereas those with temporary residency permits were less likely to have access to primary care (women: aOR 0.41 [95% CI 0.21-0.80] and heterosexual men: aOR 0.24 [95% CI 0.10-0.54] only). Women who had experience of forced sex (aOR 3.53 [95% CI 1.39-9.00]) or postmigration antenatal care (aOR 3.07 [95% CI 1.55-6.07]) were more likely to have tested for HIV as were heterosexual men who had access to primary care (aOR 3.13 [95% CI 1.58-6.13]) or reported "Good" health status (aOR 2.94 [95% CI 1.41-5.88]). Access to primary care is limited by structural determinants such as immigration and health care policy, which varies across Europe. For those migrants who can access primary care and other health services, missed opportunities for HIV testing remain a barrier to earlier testing and diagnosis for migrants in Europe. Clinicians should be aware of these potential structural barriers to HIV testing as well as low perception of HIV risk in migrant groups. ©Ibidun Fakoya, Débora Álvarez-del Arco, Andrew J Copas, Bryan Teixeira, Koen Block, Anne-Francoise Gennotte, Alain Volny-Anne, Janneke P Bil, Giota Touloumi, Julia del Amo, Fiona M Burns. Originally published in JMIR Public Health and Surveillance (http://publichealth.jmir.org), 06.11.2017.

The value of knowing better - Losses from natural hazards

NASA Astrophysics Data System (ADS)

Mysiak, J.; Galarraga, I.,; Garrido, A.; Interwies, E.; van Bers, C.; Vandenberghe, V.; Farinosi, F.; Foudi, S.; Görlitz, S.; Hernández-Mora, N.; Gil, M.; Grambow, C.

2012-04-01

In a highly emotional speech delivered last year after a series of strikes, Julia Gilbert, the Australian PM, noted that Australia has watched in horror as day after day a new chapter in natural disaster history has been written. And so did the whole world. 2011 went on to become the costliest year in terms of natural hazard losses in the recent history, with the total costs topping 380 billion US dollars. Almost a half of the insured losses were caused by a single event - the Fukushima Dai'ichi nuclear power plant accident triggered by a tsunami that followed an earthquake of MW 6.6 (Richer 9.0) magnitude. The Fukushima disaster has taught a costly lesson, once again: What you least expect, happens. The estimates of losses inflicted by natural hazards are, to put it mildly, incomplete and hardly representative of the ripple effects on regional and global economy, and the wider effects on social fabric, wellbeing and ecosystems that are notoriously difficult to monetise. The knowledge of the full magnitude of losses is not an end in itself. The economics of disasters is an emerging academic field, struggling to uncover the patterns of vulnerability to natural hazards, and provide insights useful for designing effective disaster risk reduction measures and policies. Yet the costly lessons learned are often neglected. In this paper we analyse selected significantly damaging events caused by hydrometeorological and climatologic events (floods and droughts) in four river basins/countries: Ebro/Spain, Po/Italy, Weser/Germany and Scheldt/Flanders-Belgium. Our analysis is focussed on identifying the gaps in reported damage estimates, and conducting additional original research and assessment that contribute to filling those gaps. In the case of drought, all the reference cases except the Ebro refer to the exceptionally hot and dry summer 2003. The drought event examined in the Ebro river basin is the prolonged period of deficient precipitation between 2004 and 2008. The flood reference cases are more uniformly distributed both intra- and interannually. They include Jan-Feb 2003 and Mar-Apr 2007 flood in the Ebro basin, the Oct 2000 flood in Po basin, Jul 2002 flood in Weser basin and Nov 2010 flood in the Scheldt. We have identified significant knowledge gaps in the current accounts of the impacts inflicted by the above disaster strikes. Almost no information is available about intangible, indirect and environmental costs. The structural damage is only partly examined. The existing assessment studies are based either on self-reported losses of the affected subjects and methodologies yielding divergent results about the extent (or even order of magnitude) of the losses suffered. The studies are rarely subjected to a critical analysis and quality check. Uncertainty surrounding the damage estimates is either omitted or reported only as a range of the likely magnitude of the disaster costs. Our analysis offers a systematic review of the damage across the affected sectors and communities. A number of assessment techniques were applied and their, pros and cons discussed. The paper highlights the value of an in-depth assessment of significantly damaging events for a better understanding of vulnerability, that is likely to be amplified as a result of anthropogenic climate change and economic development in the hazard-prone areas.

Waking-up to Science!

NASA Astrophysics Data System (ADS)

2007-03-01

The Science on Stage festival as an alarm clock for science teaching How is Europe to tackle its shortage of scientists? The EIROforum Science on Stage festival aims to give European teachers some of the answers they need to take up this urgent challenge. This unique event, showcasing the very best of today's science education, will feature science demonstrations, a science teaching fair with some 66 stands, and a Round Table discussion with the participation of the European Commissioner for Science and Research, Janez Potočnik. ESO PR Photo 14/07 ESO PR Photo 14/07 Science on Stage will have the city of Grenoble (France) buzzing from 2 to 6 April 2007. A rugby team and a hockey team will take on the power of the vacuum, a cook will demonstrate how science can inspire new culinary ideas, visitors will discover the real colour of the sun, an inflatable model of Borromini's gallery will help to explain the science of optical illusions, and Merlin himself will reveal all about how to make a cake float. These are just some of the exciting things that will be happening at the EIROforum Science on Stage festival. By showing how fascinating and entertaining science can be, the event aims to attract young people to science and ultimately help to reduce the shortage of scientists in Europe. With support from the European Commission, this international festival will bring together some 500 science educators from 27 European countries. The highlight of the festival will be a Round Table discussion on 'Science Education in the Age of the Knowledge Society - Strengthening Science Education in Europe', which will take place on 5 April 2007 with the participation of the European Commissioner for Science and Research, Janez Potočnik. The panellists - all high-ranking decision-makers - will include the Danish Minister for Education, Bertel Haarder, the MEP Vittorio Prodi, and the Chair of the UK's Engineering and Physical Sciences Research Council, Julia Higgins. "Curiosity is in our genes", says Potočnik. "Unfortunately it tends to die away when we grow up. This is because the ways we raise and educate our children and the ways we work and live do not always support innovative thinking and doing. We cannot change this overnight. But I think it is worth making the effort to awaken this dormant passion and initiatives like Science on Stage can be a very effective alarm clock", he adds. The festival will close with the presentation of the European Science Teaching Awards. The teaching materials and methods voted to be the best in Europe will then be presented in the 'Science in School' magazine, distributed free of charge to 30,000 teachers in Europe. The festival is the climax of a two-year programme of events organised in virtually every European country and from which delegates have been selected for their outstanding projects for promoting science. The winners of ESO's Catch a Star! 2007 contest will also be announced during the Science on Stage festival. The event follows on from the hugely successful 'Physics on Stage' and 'Science on Stage' festivals organised by EIROforum in 2000, 2002, 2003 and 2005. Journalists are cordially invited to take part in this unique European event. Practical information, including the detailed festival programme, is available on the Science on Stage web site at http://www.ill.fr/scienceonstage2007. A detailed press kit is available at http://www.ill.fr/scienceonstage2007/fichiers/SOSpresskit.pdf

Does rational selection of training and test sets improve the outcome of QSAR modeling?

PubMed

Martin, Todd M; Harten, Paul; Young, Douglas M; Muratov, Eugene N; Golbraikh, Alexander; Zhu, Hao; Tropsha, Alexander

2012-10-22

Prior to using a quantitative structure activity relationship (QSAR) model for external predictions, its predictive power should be established and validated. In the absence of a true external data set, the best way to validate the predictive ability of a model is to perform its statistical external validation. In statistical external validation, the overall data set is divided into training and test sets. Commonly, this splitting is performed using random division. Rational splitting methods can divide data sets into training and test sets in an intelligent fashion. The purpose of this study was to determine whether rational division methods lead to more predictive models compared to random division. A special data splitting procedure was used to facilitate the comparison between random and rational division methods. For each toxicity end point, the overall data set was divided into a modeling set (80% of the overall set) and an external evaluation set (20% of the overall set) using random division. The modeling set was then subdivided into a training set (80% of the modeling set) and a test set (20% of the modeling set) using rational division methods and by using random division. The Kennard-Stone, minimal test set dissimilarity, and sphere exclusion algorithms were used as the rational division methods. The hierarchical clustering, random forest, and k-nearest neighbor (kNN) methods were used to develop QSAR models based on the training sets. For kNN QSAR, multiple training and test sets were generated, and multiple QSAR models were built. The results of this study indicate that models based on rational division methods generate better statistical results for the test sets than models based on random division, but the predictive power of both types of models are comparable.

Home advantage in high-level volleyball varies according to set number.

PubMed

Marcelino, Rui; Mesquita, Isabel; Palao Andrés, José Manuel; Sampaio, Jaime

2009-01-01

The aim of the present study was to identify the probability of winning each Volleyball set according to game location (home, away). Archival data was obtained from 275 sets in the 2005 Men's Senior World League and 65,949 actions were analysed. Set result (win, loss), game location (home, away), set number (first, second, third, fourth and fifth) and performance indicators (serve, reception, set, attack, dig and block) were the variables considered in this study. In a first moment, performance indicators were used in a logistic model of set result, by binary logistic regression analysis. After finding the adjusted logistic model, the log-odds of winning the set were analysed according to game location and set number. The results showed that winning a set is significantly related to performance indicators (Chisquare(18)=660.97, p<0.01). Analyses of log-odds of winning a set demonstrate that home teams always have more probability of winning the game than away teams, regardless of the set number. Home teams have more advantage at the beginning of the game (first set) and in the two last sets of the game (fourth and fifth sets), probably due to facilities familiarity and crowd effects. Different game actions explain these advantages and showed that to win the first set is more important to take risk, through a better performance in the attack and block, and to win the final set is important to manage the risk through a better performance on the reception. These results may suggest intra-game variation in home advantage and can be most useful to better prepare and direct the competition. Key pointsHome teams always have more probability of winning the game than away teams.Home teams have higher performance in reception, set and attack in the total of the sets.The advantage of home teams is more pronounced at the beginning of the game (first set) and in two last sets of the game (fourth and fifth sets) suggesting intra-game variation in home advantage.Analysis by sets showed that home teams have a better performance in the attack and block in the first set and in the reception in the third and fifth sets.

Histone H3K4 methylation-dependent and -independent functions of Set1A/COMPASS in embryonic stem cell self-renewal and differentiation.

PubMed

Sze, Christie C; Cao, Kaixiang; Collings, Clayton K; Marshall, Stacy A; Rendleman, Emily J; Ozark, Patrick A; Chen, Fei Xavier; Morgan, Marc A; Wang, Lu; Shilatifard, Ali

2017-09-01

Of the six members of the COMPASS (complex of proteins associated with Set1) family of histone H3 Lys4 (H3K4) methyltransferases identified in mammals, Set1A has been shown to be essential for early embryonic development and the maintenance of embryonic stem cell (ESC) self-renewal. Like its familial relatives, Set1A possesses a catalytic SET domain responsible for histone H3K4 methylation. Whether H3K4 methylation by Set1A/COMPASS is required for ESC maintenance and during differentiation has not yet been addressed. Here, we generated ESCs harboring the deletion of the SET domain of Set1A (Set1A ΔSET ); surprisingly, the Set1A SET domain is dispensable for ESC proliferation and self-renewal. The removal of the Set1A SET domain does not diminish bulk H3K4 methylation in ESCs; instead, only a subset of genomic loci exhibited reduction in H3K4me3 in Set1A ΔSET cells, suggesting a role for Set1A independent of its catalytic domain in ESC self-renewal. However, Set1A ΔSET ESCs are unable to undergo normal differentiation, indicating the importance of Set1A-dependent H3K4 methylation during differentiation. Our data also indicate that during differentiation, Set1A but not Mll2 functions as the H3K4 methylase on bivalent genes and is required for their expression, supporting a model for transcriptional switch between Mll2 and Set1A during the self-renewing-to-differentiation transition. Together, our study implicates a critical role for Set1A catalytic methyltransferase activity in regulating ESC differentiation but not self-renewal and suggests the existence of context-specific H3K4 methylation that regulates transcriptional outputs during ESC pluripotency. © 2017 Sze et al.; Published by Cold Spring Harbor Laboratory Press.

Processing data base information having nonwhite noise

DOEpatents

Gross, Kenneth C.; Morreale, Patricia

1995-01-01

A method and system for processing a set of data from an industrial process and/or a sensor. The method and system can include processing data from either real or calculated data related to an industrial process variable. One of the data sets can be an artificial signal data set generated by an autoregressive moving average technique. After obtaining two data sets associated with one physical variable, a difference function data set is obtained by determining the arithmetic difference between the two pairs of data sets over time. A frequency domain transformation is made of the difference function data set to obtain Fourier modes describing a composite function data set. A residual function data set is obtained by subtracting the composite function data set from the difference function data set and the residual function data set (free of nonwhite noise) is analyzed by a statistical probability ratio test to provide a validated data base.

Rough set classification based on quantum logic

NASA Astrophysics Data System (ADS)

Hassan, Yasser F.

2017-11-01

By combining the advantages of quantum computing and soft computing, the paper shows that rough sets can be used with quantum logic for classification and recognition systems. We suggest the new definition of rough set theory as quantum logic theory. Rough approximations are essential elements in rough set theory, the quantum rough set model for set-valued data directly construct set approximation based on a kind of quantum similarity relation which is presented here. Theoretical analyses demonstrate that the new model for quantum rough sets has new type of decision rule with less redundancy which can be used to give accurate classification using principles of quantum superposition and non-linear quantum relations. To our knowledge, this is the first attempt aiming to define rough sets in representation of a quantum rather than logic or sets. The experiments on data-sets have demonstrated that the proposed model is more accuracy than the traditional rough sets in terms of finding optimal classifications.

Processing Device for High-Speed Execution of an Xrisc Computer Program

NASA Technical Reports Server (NTRS)

Ng, Tak-Kwong (Inventor); Mills, Carl S. (Inventor)

2016-01-01

A processing device for high-speed execution of a computer program is provided. A memory module may store one or more computer programs. A sequencer may select one of the computer programs and controls execution of the selected program. A register module may store intermediate values associated with a current calculation set, a set of output values associated with a previous calculation set, and a set of input values associated with a subsequent calculation set. An external interface may receive the set of input values from a computing device and provides the set of output values to the computing device. A computation interface may provide a set of operands for computation during processing of the current calculation set. The set of input values are loaded into the register and the set of output values are unloaded from the register in parallel with processing of the current calculation set.

A strategy to improve priority setting in developing countries.

PubMed

Kapiriri, Lydia; Martin, Douglas K

2007-09-01

Because the demand for health services outstrips the available resources, priority setting is one of the most difficult issues faced by health policy makers, particularly those in developing countries. Priority setting in developing countries is fraught with uncertainty due to lack of credible information, weak priority setting institutions, and unclear priority setting processes. Efforts to improve priority setting in these contexts have focused on providing information and tools. In this paper we argue that priority setting is a value laden and political process, and although important, the available information and tools are not sufficient to address the priority setting challenges in developing countries. Additional complementary efforts are required. Hence, a strategy to improve priority setting in developing countries should also include: (i) capturing current priority setting practices, (ii) improving the legitimacy and capacity of institutions that set priorities, and (iii) developing fair priority setting processes.

Magnetoresistance in single-electron transistors comprising a superconducting island with ferromagnetic leads

NASA Astrophysics Data System (ADS)

Mizugaki, Yoshinao; Takiguchi, Masashi; Tamura, Nobuyuki; Shimada, Hiroshi

2018-03-01

We report electric and magnetic field responses of single-electron transistors (SETs) comprising a superconducting island with ferromagnetic (FM) leads. We fabricated two SETs, one of which had relatively high resistance and the other had relatively low resistance. The SETs had two states for the gate charge: SET-ON or SET-OFF. They also had two states for the FM lead magnetization: parallel (P) or anti-parallel (AP) configuration. Current-voltage characteristics of four SET states (“P & SET-ON,” “P & SET-OFF,” “AP & SET-ON,” and “AP & SET-OFF”) were measured at approximately 0.1 K in a compact dilution refrigerator. Magnetoresistance ratio (MRR) values were obtained for the SET-ON and SET-OFF states, respectively. The higher-resistance SET1 exhibited positive MRR values for all measured bias voltages. The MRR enhancement was confirmed for the SET-OFF state, which agreed well with the co-tunneling model. The lower-resistance SET2, on the other hand, exhibited negative and positive MRR values for higher and lower bias voltage conditions, respectively. The bias voltage for the MRR polarity reversal was changed by the gate voltage. It was also confirmed that the co-tunneling model was partially valid for negative MRR values.

13 CFR 121.406 - How does a small business concern qualify to provide manufactured products or other supply items...

Code of Federal Regulations, 2013 CFR

2013-01-01

...-disabled veteran-owned small business set-aside, WOSB or EDWOSB set-aside, or 8(a) contract? 121.406... items under a small business set-aside, service-disabled veteran-owned small business set-aside, WOSB or... small business set-aside, service-disabled veteran-owned small business set-aside, WOSB or EDWOSB set...

13 CFR 121.406 - How does a small business concern qualify to provide manufactured products or other supply items...

Code of Federal Regulations, 2014 CFR

2014-01-01

...-disabled veteran-owned small business set-aside, WOSB or EDWOSB set-aside, or 8(a) contract? 121.406... items under a small business set-aside, service-disabled veteran-owned small business set-aside, WOSB or... small business set-aside, service-disabled veteran-owned small business set-aside, WOSB or EDWOSB set...

13 CFR 121.406 - How does a small business concern qualify to provide manufactured products or other supply items...

Code of Federal Regulations, 2012 CFR

2012-01-01

...-disabled veteran-owned small business set-aside, WOSB or EDWOSB set-aside, or 8(a) contract? 121.406... items under a small business set-aside, service-disabled veteran-owned small business set-aside, WOSB or... small business set-aside, service-disabled veteran-owned small business set-aside, WOSB or EDWOSB set...

78 FR 60003 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-30

... month, per display application per Data Set \\5\\ of Real-Time \\6\\ TRACE transaction data. The fee waiver... data available in three Data Sets--the Corporate Bond Data Set, the Agency Data Set and the ABS Data Set. A fourth Data Set, the Rule 144A Data Set, will become available in 2014. See Securities Exchange...

An Independent Filter for Gene Set Testing Based on Spectral Enrichment.

PubMed

Frost, H Robert; Li, Zhigang; Asselbergs, Folkert W; Moore, Jason H

2015-01-01

Gene set testing has become an indispensable tool for the analysis of high-dimensional genomic data. An important motivation for testing gene sets, rather than individual genomic variables, is to improve statistical power by reducing the number of tested hypotheses. Given the dramatic growth in common gene set collections, however, testing is often performed with nearly as many gene sets as underlying genomic variables. To address the challenge to statistical power posed by large gene set collections, we have developed spectral gene set filtering (SGSF), a novel technique for independent filtering of gene set collections prior to gene set testing. The SGSF method uses as a filter statistic the p-value measuring the statistical significance of the association between each gene set and the sample principal components (PCs), taking into account the significance of the associated eigenvalues. Because this filter statistic is independent of standard gene set test statistics under the null hypothesis but dependent under the alternative, the proportion of enriched gene sets is increased without impacting the type I error rate. As shown using simulated and real gene expression data, the SGSF algorithm accurately filters gene sets unrelated to the experimental outcome resulting in significantly increased gene set testing power.

The N-terminal Set-β Protein Isoform Induces Neuronal Death*

PubMed Central

Trakhtenberg, Ephraim F.; Morkin, Melina I.; Patel, Karan H.; Fernandez, Stephanie G.; Sang, Alan; Shaw, Peter; Liu, Xiongfei; Wang, Yan; Mlacker, Gregory M.; Gao, Han; Velmeshev, Dmitry; Dombrowski, Susan M.; Vitek, Michael P.; Goldberg, Jeffrey L.

2015-01-01

Set-β protein plays different roles in neurons, but the diversity of Set-β neuronal isoforms and their functions have not been characterized. The expression and subcellular localization of Set-β are altered in Alzheimer disease, cleavage of Set-β leads to neuronal death after stroke, and the full-length Set-β regulates retinal ganglion cell (RGC) and hippocampal neuron axon growth and regeneration in a subcellular localization-dependent manner. Here we used various biochemical approaches to investigate Set-β isoforms and their role in the CNS, using the same type of neurons, RGCs, across studies. We found multiple alternatively spliced isoforms expressed from the Set locus in purified RGCs. Set transcripts containing the Set-β-specific exon were the most highly expressed isoforms. We also identified a novel, alternatively spliced Set-β transcript lacking the nuclear localization signal and demonstrated that the full-length (∼39-kDa) Set-β is localized predominantly in the nucleus, whereas a shorter (∼25-kDa) Set-β isoform is localized predominantly in the cytoplasm. Finally, we show that an N-terminal Set-β cleavage product can induce neuronal death. PMID:25833944

Digital data sets for map products produced as part of the Black Hills Hydrology Study, western South Dakota

USGS Publications Warehouse

Williamson, Joyce E.; Jarrell, Gregory J.; Clawges, Rick M.; Galloway, Joel M.; Carter, Janet M.

2000-01-01

This compact disk contains digital data produced as part of the 1:100,000-scale map products for the Black Hills Hydrology Study conducted in western South Dakota. The digital data include 28 individual Geographic Information System (GIS) data sets: data sets for the hydrogeologic unit map including all mapped hydrogeologic units within the study area (1 data set) and major geologic structure including anticlines and synclines (1 data set); data sets for potentiometric maps including the potentiometric contours for the Inyan Kara, Minnekahta, Minnelusa, Madison, and Deadwood aquifers (5 data sets), wells used as control points for each aquifer (5 data sets), and springs used as control points for the potentiometric contours (1 data set); and data sets for the structure-contour maps including the structure contours for the top of each formation that contains major aquifers (5 data sets), wells and tests holes used as control points for each formation (5 data sets), and surficial deposits (alluvium and terrace deposits) that directly overlie each of the major aquifer outcrops (5 data sets). These data sets were used to produce the maps published by the U.S. Geological Survey.

Implementation of Steiner point of fuzzy set.

PubMed

Liang, Jiuzhen; Wang, Dejiang

2014-01-01

This paper deals with the implementation of Steiner point of fuzzy set. Some definitions and properties of Steiner point are investigated and extended to fuzzy set. This paper focuses on establishing efficient methods to compute Steiner point of fuzzy set. Two strategies of computing Steiner point of fuzzy set are proposed. One is called linear combination of Steiner points computed by a series of crisp α-cut sets of the fuzzy set. The other is an approximate method, which is trying to find the optimal α-cut set approaching the fuzzy set. Stability analysis of Steiner point of fuzzy set is also studied. Some experiments on image processing are given, in which the two methods are applied for implementing Steiner point of fuzzy image, and both strategies show their own advantages in computing Steiner point of fuzzy set.

Uncertainty representation of grey numbers and grey sets.

PubMed

Yang, Yingjie; Liu, Sifeng; John, Robert

2014-09-01

In the literature, there is a presumption that a grey set and an interval-valued fuzzy set are equivalent. This presumption ignores the existence of discrete components in a grey number. In this paper, new measurements of uncertainties of grey numbers and grey sets, consisting of both absolute and relative uncertainties, are defined to give a comprehensive representation of uncertainties in a grey number and a grey set. Some simple examples are provided to illustrate that the proposed uncertainty measurement can give an effective representation of both absolute and relative uncertainties in a grey number and a grey set. The relationships between grey sets and interval-valued fuzzy sets are also analyzed from the point of view of the proposed uncertainty representation. The analysis demonstrates that grey sets and interval-valued fuzzy sets provide different but overlapping models for uncertainty representation in sets.

MicroSIFT Courseware Evaluations. [Set 11 (223-259), Set 12 (260-293), and a Special Set of 99 LIBRA Reviews of Junior High School Science Software, Including Subject and Title Indexes Covering Sets 1-12 and Special Set L].

ERIC Educational Resources Information Center

Northwest Regional Educational Lab., Portland, OR.

This document consists of 170 microcomputer software package evaluations prepared by the MicroSIFT (Microcomputer Software and Information for Teachers) Clearinghouse at the Northwest Regional Education Laboratory. Set 11 consists of 37 packages. Set 12 consists of 34 packages. A special unnumbered set, entitled LIBRA Reviews, treats 99 packages…

Novel gene sets improve set-level classification of prokaryotic gene expression data.

PubMed

Holec, Matěj; Kuželka, Ondřej; Železný, Filip

2015-10-28

Set-level classification of gene expression data has received significant attention recently. In this setting, high-dimensional vectors of features corresponding to genes are converted into lower-dimensional vectors of features corresponding to biologically interpretable gene sets. The dimensionality reduction brings the promise of a decreased risk of overfitting, potentially resulting in improved accuracy of the learned classifiers. However, recent empirical research has not confirmed this expectation. Here we hypothesize that the reported unfavorable classification results in the set-level framework were due to the adoption of unsuitable gene sets defined typically on the basis of the Gene ontology and the KEGG database of metabolic networks. We explore an alternative approach to defining gene sets, based on regulatory interactions, which we expect to collect genes with more correlated expression. We hypothesize that such more correlated gene sets will enable to learn more accurate classifiers. We define two families of gene sets using information on regulatory interactions, and evaluate them on phenotype-classification tasks using public prokaryotic gene expression data sets. From each of the two gene-set families, we first select the best-performing subtype. The two selected subtypes are then evaluated on independent (testing) data sets against state-of-the-art gene sets and against the conventional gene-level approach. The novel gene sets are indeed more correlated than the conventional ones, and lead to significantly more accurate classifiers. The novel gene sets are indeed more correlated than the conventional ones, and lead to significantly more accurate classifiers. Novel gene sets defined on the basis of regulatory interactions improve set-level classification of gene expression data. The experimental scripts and other material needed to reproduce the experiments are available at http://ida.felk.cvut.cz/novelgenesets.tar.gz.

Next-generation text-mining mediated generation of chemical response-specific gene sets for interpretation of gene expression data.

PubMed

Hettne, Kristina M; Boorsma, André; van Dartel, Dorien A M; Goeman, Jelle J; de Jong, Esther; Piersma, Aldert H; Stierum, Rob H; Kleinjans, Jos C; Kors, Jan A

2013-01-29

Availability of chemical response-specific lists of genes (gene sets) for pharmacological and/or toxic effect prediction for compounds is limited. We hypothesize that more gene sets can be created by next-generation text mining (next-gen TM), and that these can be used with gene set analysis (GSA) methods for chemical treatment identification, for pharmacological mechanism elucidation, and for comparing compound toxicity profiles. We created 30,211 chemical response-specific gene sets for human and mouse by next-gen TM, and derived 1,189 (human) and 588 (mouse) gene sets from the Comparative Toxicogenomics Database (CTD). We tested for significant differential expression (SDE) (false discovery rate -corrected p-values < 0.05) of the next-gen TM-derived gene sets and the CTD-derived gene sets in gene expression (GE) data sets of five chemicals (from experimental models). We tested for SDE of gene sets for six fibrates in a peroxisome proliferator-activated receptor alpha (PPARA) knock-out GE dataset and compared to results from the Connectivity Map. We tested for SDE of 319 next-gen TM-derived gene sets for environmental toxicants in three GE data sets of triazoles, and tested for SDE of 442 gene sets associated with embryonic structures. We compared the gene sets to triazole effects seen in the Whole Embryo Culture (WEC), and used principal component analysis (PCA) to discriminate triazoles from other chemicals. Next-gen TM-derived gene sets matching the chemical treatment were significantly altered in three GE data sets, and the corresponding CTD-derived gene sets were significantly altered in five GE data sets. Six next-gen TM-derived and four CTD-derived fibrate gene sets were significantly altered in the PPARA knock-out GE dataset. None of the fibrate signatures in cMap scored significant against the PPARA GE signature. 33 environmental toxicant gene sets were significantly altered in the triazole GE data sets. 21 of these toxicants had a similar toxicity pattern as the triazoles. We confirmed embryotoxic effects, and discriminated triazoles from other chemicals. Gene set analysis with next-gen TM-derived chemical response-specific gene sets is a scalable method for identifying similarities in gene responses to other chemicals, from which one may infer potential mode of action and/or toxic effect.

Next-generation text-mining mediated generation of chemical response-specific gene sets for interpretation of gene expression data

PubMed Central

2013-01-01

Background Availability of chemical response-specific lists of genes (gene sets) for pharmacological and/or toxic effect prediction for compounds is limited. We hypothesize that more gene sets can be created by next-generation text mining (next-gen TM), and that these can be used with gene set analysis (GSA) methods for chemical treatment identification, for pharmacological mechanism elucidation, and for comparing compound toxicity profiles. Methods We created 30,211 chemical response-specific gene sets for human and mouse by next-gen TM, and derived 1,189 (human) and 588 (mouse) gene sets from the Comparative Toxicogenomics Database (CTD). We tested for significant differential expression (SDE) (false discovery rate -corrected p-values < 0.05) of the next-gen TM-derived gene sets and the CTD-derived gene sets in gene expression (GE) data sets of five chemicals (from experimental models). We tested for SDE of gene sets for six fibrates in a peroxisome proliferator-activated receptor alpha (PPARA) knock-out GE dataset and compared to results from the Connectivity Map. We tested for SDE of 319 next-gen TM-derived gene sets for environmental toxicants in three GE data sets of triazoles, and tested for SDE of 442 gene sets associated with embryonic structures. We compared the gene sets to triazole effects seen in the Whole Embryo Culture (WEC), and used principal component analysis (PCA) to discriminate triazoles from other chemicals. Results Next-gen TM-derived gene sets matching the chemical treatment were significantly altered in three GE data sets, and the corresponding CTD-derived gene sets were significantly altered in five GE data sets. Six next-gen TM-derived and four CTD-derived fibrate gene sets were significantly altered in the PPARA knock-out GE dataset. None of the fibrate signatures in cMap scored significant against the PPARA GE signature. 33 environmental toxicant gene sets were significantly altered in the triazole GE data sets. 21 of these toxicants had a similar toxicity pattern as the triazoles. We confirmed embryotoxic effects, and discriminated triazoles from other chemicals. Conclusions Gene set analysis with next-gen TM-derived chemical response-specific gene sets is a scalable method for identifying similarities in gene responses to other chemicals, from which one may infer potential mode of action and/or toxic effect. PMID:23356878

Army 86 Cost Sensitivity Analysis.

DTIC Science & Technology

1980-05-01

NI VI AN/PVS-4 W/IMG 5 Q15414 RADAR ST AN/MPQ-4A LP 25 Q16110 RADAR SET AN/PPS- SALP 773 Q34308 RADIO SET AN/GRC-160 191 Q45779 RADIO SET AN/VRC-12 654...VI AN/PVS-4 W/ING 5 Q15414 RADAR ST AN/MPQ-4A LP 25 Q16110 RADAR SET AN/PPS- SALP 592 Q34308 RADIO SET AN/GRC-160 555 Q38299 RADIO SET AN/PRC-25 474...PVS-4 W/IMG Q15414 RADAR ST AN/MPQ-4A LP Q16110 RADAR SET AN/PPS- SALP Q34308 RADIO SET AN/GRC-160 Q38299 RADIO SET AN/PRC-25 Q45779 RADIO SET AN/VRC-12

Training set selection for the prediction of essential genes.

PubMed

Cheng, Jian; Xu, Zhao; Wu, Wenwu; Zhao, Li; Li, Xiangchen; Liu, Yanlin; Tao, Shiheng

2014-01-01

Various computational models have been developed to transfer annotations of gene essentiality between organisms. However, despite the increasing number of microorganisms with well-characterized sets of essential genes, selection of appropriate training sets for predicting the essential genes of poorly-studied or newly sequenced organisms remains challenging. In this study, a machine learning approach was applied reciprocally to predict the essential genes in 21 microorganisms. Results showed that training set selection greatly influenced predictive accuracy. We determined four criteria for training set selection: (1) essential genes in the selected training set should be reliable; (2) the growth conditions in which essential genes are defined should be consistent in training and prediction sets; (3) species used as training set should be closely related to the target organism; and (4) organisms used as training and prediction sets should exhibit similar phenotypes or lifestyles. We then analyzed the performance of an incomplete training set and an integrated training set with multiple organisms. We found that the size of the training set should be at least 10% of the total genes to yield accurate predictions. Additionally, the integrated training sets exhibited remarkable increase in stability and accuracy compared with single sets. Finally, we compared the performance of the integrated training sets with the four criteria and with random selection. The results revealed that a rational selection of training sets based on our criteria yields better performance than random selection. Thus, our results provide empirical guidance on training set selection for the identification of essential genes on a genome-wide scale.

Set and setting, psychedelics and the placebo response: An extra-pharmacological perspective on psychopharmacology.

PubMed

Hartogsohn, Ido

2016-12-01

Placebo response theory and set and setting theory are two fields which examine how non-biological factors shape the response to therapy. Both consider factors such as expectancy, preparation and beliefs to be crucial for understanding the extra-pharmacological processes which shape the response to drugs. Yet there are also fundamental differences between the two theories. Set and setting concerns itself with response to psychoactive drugs only; placebo theory relates to all therapeutic interventions. Placebo theory is aimed at medical professionals; set and setting theory is aimed at professionals and drug users alike. Placebo theory is primarily descriptive, describing how placebo acts; set and setting theory is primarily prescriptive, educating therapists and users on how to control and optimize the effects of drugs. This paper examines how placebo theory and set and setting theory can complement and benefit each other, broadening our understanding of how non-biological factors shape response to drugs and other treatment interventions. © The Author(s) 2016.

Analysis of Setting Efficacy in Young Male and Female Volleyball Players.

PubMed

González-Silva, Jara; Domínguez, Alberto Moreno; Fernández-Echeverría, Carmen; Rabaz, Fernando Claver; Arroyo, M Perla Moreno

2016-12-01

The main objective of this study was to analyse the variables that predicted setting efficacy in complex I (KI) in volleyball, in formative categories and depending on gender. The study sample was comprised of 5842 game actions carried out by the 16 male category and the 18 female category teams that participated in the Under-16 Spanish Championship. The dependent variable was setting efficacy. The independent variables were grouped into: serve variables (a serve zone, the type of serve, striking technique, an in-game role of the server and serve direction), reception variables (a reception zone, a receiver player and reception efficacy) and setting variables (a setter's position, a setting zone, the type of a set, setting technique, a set's area and tempo of a set). Multinomial logistic regression showed that the best predictive variables of setting efficacy, both in female and male categories, were reception efficacy, setting technique and tempo of a set. In the male category, the jump serve was the greatest predictor of setting efficacy, while in the female category, it was the set's area. Therefore, in the male category, it was not only the preceding action that affected setting efficacy, but also the serve. On the contrary, in the female category, only variables of the action itself and of the previous action, reception, affected setting efficacy. The results obtained in the present study should be taken into account in the training process of both male and female volleyball players in formative stages.

LiPISC: A Lightweight and Flexible Method for Privacy-Aware Intersection Set Computation

PubMed Central

Huang, Shiyong; Ren, Yi; Choo, Kim-Kwang Raymond

2016-01-01

Privacy-aware intersection set computation (PISC) can be modeled as secure multi-party computation. The basic idea is to compute the intersection of input sets without leaking privacy. Furthermore, PISC should be sufficiently flexible to recommend approximate intersection items. In this paper, we reveal two previously unpublished attacks against PISC, which can be used to reveal and link one input set to another input set, resulting in privacy leakage. We coin these as Set Linkage Attack and Set Reveal Attack. We then present a lightweight and flexible PISC scheme (LiPISC) and prove its security (including against Set Linkage Attack and Set Reveal Attack). PMID:27326763

LiPISC: A Lightweight and Flexible Method for Privacy-Aware Intersection Set Computation.

PubMed

Ren, Wei; Huang, Shiyong; Ren, Yi; Choo, Kim-Kwang Raymond

2016-01-01

Privacy-aware intersection set computation (PISC) can be modeled as secure multi-party computation. The basic idea is to compute the intersection of input sets without leaking privacy. Furthermore, PISC should be sufficiently flexible to recommend approximate intersection items. In this paper, we reveal two previously unpublished attacks against PISC, which can be used to reveal and link one input set to another input set, resulting in privacy leakage. We coin these as Set Linkage Attack and Set Reveal Attack. We then present a lightweight and flexible PISC scheme (LiPISC) and prove its security (including against Set Linkage Attack and Set Reveal Attack).

The association of color memory and the enumeration of multiple spatially overlapping sets.

PubMed

Poltoratski, Sonia; Xu, Yaoda

2013-07-09

Using dot displays, Halberda, Sires, and Feigenson (2006) showed that observers could simultaneously encode the numerosity of two spatially overlapping sets and the superset of all items at a glance. With the brief display and the masking used in Halberda et al., the task required observers to encode the colors of each set in order to select and enumerate all the dots in that set. As such, the observed capacity limit for set enumeration could reflect a limit in visual short-term memory (VSTM) capacity for the set color rather than a limit in set enumeration per se. Here, we largely replicated Halberda et al. and found successful enumeration of approximately two sets (the superset was not probed). We also found that only about two and a half colors could be remembered from the colored dot displays whether or not the enumeration task was performed concurrently with the color VSTM task. Because observers must remember the color of a set prior to enumerating it, the under three-item VSTM capacity for color necessarily dictates that set enumeration capacity in this paradigm could not exceed two sets. Thus, the ability to enumerate multiple spatially overlapping sets is likely limited by VSTM capacity to retain the discriminating feature of these sets. This relationship suggests that the capacity for set enumeration cannot be considered independently from the capacity for the set's defining features.

Mining functionally relevant gene sets for analyzing physiologically novel clinical expression data.

PubMed

Turcan, Sevin; Vetter, Douglas E; Maron, Jill L; Wei, Xintao; Slonim, Donna K

2011-01-01

Gene set analyses have become a standard approach for increasing the sensitivity of transcriptomic studies. However, analytical methods incorporating gene sets require the availability of pre-defined gene sets relevant to the underlying physiology being studied. For novel physiological problems, relevant gene sets may be unavailable or existing gene set databases may bias the results towards only the best-studied of the relevant biological processes. We describe a successful attempt to mine novel functional gene sets for translational projects where the underlying physiology is not necessarily well characterized in existing annotation databases. We choose targeted training data from public expression data repositories and define new criteria for selecting biclusters to serve as candidate gene sets. Many of the discovered gene sets show little or no enrichment for informative Gene Ontology terms or other functional annotation. However, we observe that such gene sets show coherent differential expression in new clinical test data sets, even if derived from different species, tissues, and disease states. We demonstrate the efficacy of this method on a human metabolic data set, where we discover novel, uncharacterized gene sets that are diagnostic of diabetes, and on additional data sets related to neuronal processes and human development. Our results suggest that our approach may be an efficient way to generate a collection of gene sets relevant to the analysis of data for novel clinical applications where existing functional annotation is relatively incomplete.

The Context Dependency of the Self-Report Version of the Strength and Difficulties Questionnaire (SDQ): A Cross-Sectional Study between Two Administration Settings

PubMed Central

Hoofs, H.; Jansen, N. W. H.; Mohren, D. C. L.; Jansen, M. W. J.; Kant, I. J.

2015-01-01

Background The Strength and Difficulties Questionnaire (SDQ) is a screening instrument for psychosocial problems in children and adolescents, which is applied in “individual” and “collective” settings. Assessment in the individual setting is confidential for clinical applications, such as preventive child healthcare, while assessment in the collective setting is anonymous and applied in (epidemiological) research. Due to administration differences between the settings it remains unclear whether results and conclusions actually can be used interchangeably. This study therefore aims to investigate whether the SDQ is invariant across settings. Methods Two independent samples were retrieved (mean age = 14.07 years), one from an individual setting (N = 6,594) and one from a collective setting (N = 4,613). The SDQ was administered in the second year of secondary school in both settings. Samples come from the same socio-geographic population in the Netherlands. Results Confirmatory factor analysis showed that the SDQ was measurement invariant/equivalent across settings and gender. On average, children in the individual setting scored lower on total difficulties (mean difference = 2.05) and the psychosocial problems subscales compared to those in the collective setting. This was also reflected in the cut-off points for caseness, defined by the 90th percentiles, which were lower in the individual setting. Using cut-off points from the collective in the individual setting therefore resulted in a small number of cases, 2 to 3%, while ∼10% is expected. Conclusion The SDQ has the same connotation across the individual and collective setting. The observed structural differences regarding the mean scores, however, undermine the validity of the cross-use of absolute SDQ-scores between these settings. Applying cut-off scores from the collective setting in the individual setting could, therefore, result in invalid conclusions and potential misuse of the instrument. To correctly apply cut-off scores these should be retrieved from the applied setting. PMID:25886464

GPI Calibrations

NASA Astrophysics Data System (ADS)

Rantakyrö, Fredrik T.

2017-09-01

"The Gemini Planet Imager requires a large set of Calibrations. These can be split into two major sets, one set associated with each observation and one set related to biweekly calibrations. The observation set is to optimize the correction of miscroshifts in the IFU spectra and the latter set is for correction of detector and instrument cosmetics."

Electrical system using phase-shifted carrier signals and related operating methods

DOEpatents

Welchko, Brian A; Campbell, Jeremy B

2012-09-18

An automotive drive system and methods for making the same are provided. The system includes a three-phase motor and an inverter module. The three-phase motor includes a first set of windings each having a first magnetic polarity; and a second set of windings each having a second magnetic polarity that is opposite the first magnetic polarity. The first set of windings being electrically isolated from the second set of windings. The inverter module includes a first set of phase legs and a second set of phase legs. Each one of the first set of phase legs is coupled to a corresponding phase of the first set of windings, and each one of the second set of phase legs is coupled to a corresponding phase of the second set of windings.

Single vs. multiple sets of resistance exercise for muscle hypertrophy: a meta-analysis.

PubMed

Krieger, James W

2010-04-01

Previous meta-analyses have compared the effects of single to multiple sets on strength, but analyses on muscle hypertrophy are lacking. The purpose of this study was to use multilevel meta-regression to compare the effects of single and multiple sets per exercise on muscle hypertrophy. The analysis comprised 55 effect sizes (ESs), nested within 19 treatment groups and 8 studies. Multiple sets were associated with a larger ES than a single set (difference = 0.10 +/- 0.04; confidence interval [CI]: 0.02, 0.19; p = 0.016). In a dose-response model, there was a trend for 2-3 sets per exercise to be associated with a greater ES than 1 set (difference = 0.09 +/- 0.05; CI: -0.02, 0.20; p = 0.09), and a trend for 4-6 sets per exercise to be associated with a greater ES than 1 set (difference = 0.20 +/- 0.11; CI: -0.04, 0.43; p = 0.096). Both of these trends were significant when considering permutation test p values (p < 0.01). There was no significant difference between 2-3 sets per exercise and 4-6 sets per exercise (difference = 0.10 +/- 0.10; CI: -0.09, 0.30; p = 0.29). There was a tendency for increasing ESs for an increasing number of sets (0.24 for 1 set, 0.34 for 2-3 sets, and 0.44 for 4-6 sets). Sensitivity analysis revealed no highly influential studies that affected the magnitude of the observed differences, but one study did slightly influence the level of significance and CI width. No evidence of publication bias was observed. In conclusion, multiple sets are associated with 40% greater hypertrophy-related ESs than 1 set, in both trained and untrained subjects.

Decomposition of Fuzzy Soft Sets with Finite Value Spaces

PubMed Central

Jun, Young Bae

2014-01-01

The notion of fuzzy soft sets is a hybrid soft computing model that integrates both gradualness and parameterization methods in harmony to deal with uncertainty. The decomposition of fuzzy soft sets is of great importance in both theory and practical applications with regard to decision making under uncertainty. This study aims to explore decomposition of fuzzy soft sets with finite value spaces. Scalar uni-product and int-product operations of fuzzy soft sets are introduced and some related properties are investigated. Using t-level soft sets, we define level equivalent relations and show that the quotient structure of the unit interval induced by level equivalent relations is isomorphic to the lattice consisting of all t-level soft sets of a given fuzzy soft set. We also introduce the concepts of crucial threshold values and complete threshold sets. Finally, some decomposition theorems for fuzzy soft sets with finite value spaces are established, illustrated by an example concerning the classification and rating of multimedia cell phones. The obtained results extend some classical decomposition theorems of fuzzy sets, since every fuzzy set can be viewed as a fuzzy soft set with a single parameter. PMID:24558342

Decomposition of fuzzy soft sets with finite value spaces.

PubMed

Feng, Feng; Fujita, Hamido; Jun, Young Bae; Khan, Madad

2014-01-01

The notion of fuzzy soft sets is a hybrid soft computing model that integrates both gradualness and parameterization methods in harmony to deal with uncertainty. The decomposition of fuzzy soft sets is of great importance in both theory and practical applications with regard to decision making under uncertainty. This study aims to explore decomposition of fuzzy soft sets with finite value spaces. Scalar uni-product and int-product operations of fuzzy soft sets are introduced and some related properties are investigated. Using t-level soft sets, we define level equivalent relations and show that the quotient structure of the unit interval induced by level equivalent relations is isomorphic to the lattice consisting of all t-level soft sets of a given fuzzy soft set. We also introduce the concepts of crucial threshold values and complete threshold sets. Finally, some decomposition theorems for fuzzy soft sets with finite value spaces are established, illustrated by an example concerning the classification and rating of multimedia cell phones. The obtained results extend some classical decomposition theorems of fuzzy sets, since every fuzzy set can be viewed as a fuzzy soft set with a single parameter.

Random forests-based differential analysis of gene sets for gene expression data.

PubMed

Hsueh, Huey-Miin; Zhou, Da-Wei; Tsai, Chen-An

2013-04-10

In DNA microarray studies, gene-set analysis (GSA) has become the focus of gene expression data analysis. GSA utilizes the gene expression profiles of functionally related gene sets in Gene Ontology (GO) categories or priori-defined biological classes to assess the significance of gene sets associated with clinical outcomes or phenotypes. Many statistical approaches have been proposed to determine whether such functionally related gene sets express differentially (enrichment and/or deletion) in variations of phenotypes. However, little attention has been given to the discriminatory power of gene sets and classification of patients. In this study, we propose a method of gene set analysis, in which gene sets are used to develop classifications of patients based on the Random Forest (RF) algorithm. The corresponding empirical p-value of an observed out-of-bag (OOB) error rate of the classifier is introduced to identify differentially expressed gene sets using an adequate resampling method. In addition, we discuss the impacts and correlations of genes within each gene set based on the measures of variable importance in the RF algorithm. Significant classifications are reported and visualized together with the underlying gene sets and their contribution to the phenotypes of interest. Numerical studies using both synthesized data and a series of publicly available gene expression data sets are conducted to evaluate the performance of the proposed methods. Compared with other hypothesis testing approaches, our proposed methods are reliable and successful in identifying enriched gene sets and in discovering the contributions of genes within a gene set. The classification results of identified gene sets can provide an valuable alternative to gene set testing to reveal the unknown, biologically relevant classes of samples or patients. In summary, our proposed method allows one to simultaneously assess the discriminatory ability of gene sets and the importance of genes for interpretation of data in complex biological systems. The classifications of biologically defined gene sets can reveal the underlying interactions of gene sets associated with the phenotypes, and provide an insightful complement to conventional gene set analyses. Copyright © 2012 Elsevier B.V. All rights reserved.

Mode synthesizing atomic force microscopy and mode-synthesizing sensing

DOEpatents

Passian, Ali; Thundat, Thomas George; Tetard, Laurene

2013-05-17

A method of analyzing a sample that includes applying a first set of energies at a first set of frequencies to a sample and applying, simultaneously with the applying the first set of energies, a second set of energies at a second set of frequencies, wherein the first set of energies and the second set of energies form a multi-mode coupling. The method further includes detecting an effect of the multi-mode coupling.

Mode-synthesizing atomic force microscopy and mode-synthesizing sensing

DOEpatents

Passain, Ali; Thundat, Thomas George; Tetard, Laurene

2014-07-22

A method of analyzing a sample that includes applying a first set of energies at a first set of frequencies to a sample and applying, simultaneously with the applying the first set of energies, a second set of energies at a second set of frequencies, wherein the first set of energies and the second set of energies form a multi-mode coupling. The method further includes detecting an effect of the multi-mode coupling.

MicroSIFT Courseware Evaluations [Set 15 (362-388) and Set 16 (389-441), with an Index Listing the Contents of Each Set (Sets 1-16) and a Cumulative Subject Index (Sets 1-16)].

ERIC Educational Resources Information Center

Northwest Regional Educational Lab., Portland, OR.

This document consists of 80 microcomputer software package evaluations prepared by the MicroSIFT (Microcomputer Software and Information for Teachers) Clearinghouse at the Northwest Regional Education Laboratory. Set 15 consists of 27 packages; set 16 consists of 53 packages. Each software review lists producer, time and place of evaluation,…

Dissociating Stimulus-Set and Response-Set in the Context of Task-Set Switching

ERIC Educational Resources Information Center

Kieffaber, Paul D.; Kruschke, John K.; Cho, Raymond Y.; Walker, Philip M.; Hetrick, William P.

2013-01-01

The primary aim of the present research was to determine how "stimulus-set" and "response-set" components of task-set contribute to switch costs and conflict processing. Three experiments are described wherein participants completed an explicitly cued task-switching procedure. Experiment 1 established that task switches requiring a reconfiguration…

Eastern and Western Data Sets | Grid Modernization | NREL

Science.gov Websites

and Western Data Sets Eastern and Western Data Sets The Eastern Wind Integration Data Set and Western Wind Integration Data Set were designed to perform wind integration studies and estimate power production from hypothetical wind power plants in the United States. These data sets can help energy

40 CFR 141.172 - Disinfection profiling and benchmarking.

Code of Federal Regulations, 2013 CFR

2013-07-01

... more representative annual data set than the data set determined under paragraph (a)(1) or (2) of this... may require that a system use a more representative annual data set than the data set determined under... data set than the data set determined under paragraph (a)(2)(i) of this section, the system must submit...

40 CFR 141.172 - Disinfection profiling and benchmarking.

Code of Federal Regulations, 2012 CFR

2012-07-01

... more representative annual data set than the data set determined under paragraph (a)(1) or (2) of this... may require that a system use a more representative annual data set than the data set determined under... data set than the data set determined under paragraph (a)(2)(i) of this section, the system must submit...

40 CFR 141.172 - Disinfection profiling and benchmarking.

Code of Federal Regulations, 2014 CFR

2014-07-01

... more representative annual data set than the data set determined under paragraph (a)(1) or (2) of this... may require that a system use a more representative annual data set than the data set determined under... data set than the data set determined under paragraph (a)(2)(i) of this section, the system must submit...

Goal setting and action planning in the rehabilitation setting: development of a theoretically informed practice framework.

PubMed

Scobbie, Lesley; Dixon, Diane; Wyke, Sally

2011-05-01

Setting and achieving goals is fundamental to rehabilitation practice but has been criticized for being a-theoretical and the key components of replicable goal-setting interventions are not well established. To describe the development of a theory-based goal setting practice framework for use in rehabilitation settings and to detail its component parts. Causal modelling was used to map theories of behaviour change onto the process of setting and achieving rehabilitation goals, and to suggest the mechanisms through which patient outcomes are likely to be affected. A multidisciplinary task group developed the causal model into a practice framework for use in rehabilitation settings through iterative discussion and implementation with six patients. Four components of a goal-setting and action-planning practice framework were identified: (i) goal negotiation, (ii) goal identification, (iii) planning, and (iv) appraisal and feedback. The variables hypothesized to effect change in patient outcomes were self-efficacy and action plan attainment. A theory-based goal setting practice framework for use in rehabilitation settings is described. The framework requires further development and systematic evaluation in a range of rehabilitation settings.

Boosting standard order sets utilization through clinical decision support.

PubMed

Li, Haomin; Zhang, Yinsheng; Cheng, Haixia; Lu, Xudong; Duan, Huilong

2013-01-01

Well-designed standard order sets have the potential to integrate and coordinate care by communicating best practices through multiple disciplines, levels of care, and services. However, there are several challenges which certainly affected the benefits expected from standard order sets. To boost standard order sets utilization, a problem-oriented knowledge delivery solution was proposed in this study to facilitate access of standard order sets and evaluation of its treatment effect. In this solution, standard order sets were created along with diagnostic rule sets which can trigger a CDS-based reminder to help clinician quickly discovery hidden clinical problems and corresponding standard order sets during ordering. Those rule set also provide indicators for targeted evaluation of standard order sets during treatment. A prototype system was developed based on this solution and will be presented at Medinfo 2013.

The cognitive loci of the display and task-relevant set size effects on distractor interference: Evidence from a dual-task paradigm.

PubMed

Park, Bo Youn; Kim, Sujin; Cho, Yang Seok

2018-02-01

The congruency effect of a task-irrelevant distractor has been found to be modulated by task-relevant set size and display set size. The present study used a psychological refractory period (PRP) paradigm to examine the cognitive loci of the display set size effect (dilution effect) and the task-relevant set size effect (perceptual load effect) on distractor interference. A tone discrimination task (Task 1), in which a response was made to the pitch of the target tone, was followed by a letter discrimination task (Task 2) in which different types of visual target display were used. In Experiment 1, in which display set size was manipulated to examine the nature of the display set size effect on distractor interference in Task 2, the modulation of the congruency effect by display set size was observed at both short and long stimulus-onset asynchronies (SOAs), indicating that the display set size effect occurred after the target was selected for processing in the focused attention stage. In Experiment 2, in which task-relevant set size was manipulated to examine the nature of the task-relevant set size effect on distractor interference in Task 2, the effects of task-relevant set size increased with SOA, suggesting that the target selection efficiency in the preattentive stage was impaired with increasing task-relevant set size. These results suggest that display set size and task-relevant set size modulate distractor processing in different ways.

Estimating the CCSD basis-set limit energy from small basis sets: basis-set extrapolations vs additivity schemes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Spackman, Peter R.; Karton, Amir, E-mail: amir.karton@uwa.edu.au

Coupled cluster calculations with all single and double excitations (CCSD) converge exceedingly slowly with the size of the one-particle basis set. We assess the performance of a number of approaches for obtaining CCSD correlation energies close to the complete basis-set limit in conjunction with relatively small DZ and TZ basis sets. These include global and system-dependent extrapolations based on the A + B/L{sup α} two-point extrapolation formula, and the well-known additivity approach that uses an MP2-based basis-set-correction term. We show that the basis set convergence rate can change dramatically between different systems(e.g.it is slower for molecules with polar bonds and/ormore » second-row elements). The system-dependent basis-set extrapolation scheme, in which unique basis-set extrapolation exponents for each system are obtained from lower-cost MP2 calculations, significantly accelerates the basis-set convergence relative to the global extrapolations. Nevertheless, we find that the simple MP2-based basis-set additivity scheme outperforms the extrapolation approaches. For example, the following root-mean-squared deviations are obtained for the 140 basis-set limit CCSD atomization energies in the W4-11 database: 9.1 (global extrapolation), 3.7 (system-dependent extrapolation), and 2.4 (additivity scheme) kJ mol{sup –1}. The CCSD energy in these approximations is obtained from basis sets of up to TZ quality and the latter two approaches require additional MP2 calculations with basis sets of up to QZ quality. We also assess the performance of the basis-set extrapolations and additivity schemes for a set of 20 basis-set limit CCSD atomization energies of larger molecules including amino acids, DNA/RNA bases, aromatic compounds, and platonic hydrocarbon cages. We obtain the following RMSDs for the above methods: 10.2 (global extrapolation), 5.7 (system-dependent extrapolation), and 2.9 (additivity scheme) kJ mol{sup –1}.« less

Estimating the CCSD basis-set limit energy from small basis sets: basis-set extrapolations vs additivity schemes

NASA Astrophysics Data System (ADS)

Spackman, Peter R.; Karton, Amir

2015-05-01

Coupled cluster calculations with all single and double excitations (CCSD) converge exceedingly slowly with the size of the one-particle basis set. We assess the performance of a number of approaches for obtaining CCSD correlation energies close to the complete basis-set limit in conjunction with relatively small DZ and TZ basis sets. These include global and system-dependent extrapolations based on the A + B/Lα two-point extrapolation formula, and the well-known additivity approach that uses an MP2-based basis-set-correction term. We show that the basis set convergence rate can change dramatically between different systems(e.g.it is slower for molecules with polar bonds and/or second-row elements). The system-dependent basis-set extrapolation scheme, in which unique basis-set extrapolation exponents for each system are obtained from lower-cost MP2 calculations, significantly accelerates the basis-set convergence relative to the global extrapolations. Nevertheless, we find that the simple MP2-based basis-set additivity scheme outperforms the extrapolation approaches. For example, the following root-mean-squared deviations are obtained for the 140 basis-set limit CCSD atomization energies in the W4-11 database: 9.1 (global extrapolation), 3.7 (system-dependent extrapolation), and 2.4 (additivity scheme) kJ mol-1. The CCSD energy in these approximations is obtained from basis sets of up to TZ quality and the latter two approaches require additional MP2 calculations with basis sets of up to QZ quality. We also assess the performance of the basis-set extrapolations and additivity schemes for a set of 20 basis-set limit CCSD atomization energies of larger molecules including amino acids, DNA/RNA bases, aromatic compounds, and platonic hydrocarbon cages. We obtain the following RMSDs for the above methods: 10.2 (global extrapolation), 5.7 (system-dependent extrapolation), and 2.9 (additivity scheme) kJ mol-1.

An Efficient Distributed Compressed Sensing Algorithm for Decentralized Sensor Network.

PubMed

Liu, Jing; Huang, Kaiyu; Zhang, Guoxian

2017-04-20

We consider the joint sparsity Model 1 (JSM-1) in a decentralized scenario, where a number of sensors are connected through a network and there is no fusion center. A novel algorithm, named distributed compact sensing matrix pursuit (DCSMP), is proposed to exploit the computational and communication capabilities of the sensor nodes. In contrast to the conventional distributed compressed sensing algorithms adopting a random sensing matrix, the proposed algorithm focuses on the deterministic sensing matrices built directly on the real acquisition systems. The proposed DCSMP algorithm can be divided into two independent parts, the common and innovation support set estimation processes. The goal of the common support set estimation process is to obtain an estimated common support set by fusing the candidate support set information from an individual node and its neighboring nodes. In the following innovation support set estimation process, the measurement vector is projected into a subspace that is perpendicular to the subspace spanned by the columns indexed by the estimated common support set, to remove the impact of the estimated common support set. We can then search the innovation support set using an orthogonal matching pursuit (OMP) algorithm based on the projected measurement vector and projected sensing matrix. In the proposed DCSMP algorithm, the process of estimating the common component/support set is decoupled with that of estimating the innovation component/support set. Thus, the inaccurately estimated common support set will have no impact on estimating the innovation support set. It is proven that under the condition the estimated common support set contains the true common support set, the proposed algorithm can find the true innovation set correctly. Moreover, since the innovation support set estimation process is independent of the common support set estimation process, there is no requirement for the cardinality of both sets; thus, the proposed DCSMP algorithm is capable of tackling the unknown sparsity problem successfully.

Correlation consistent basis sets for the atoms In–Xe

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mahler, Andrew; Wilson, Angela K., E-mail: akwilson@unt.edu

In this work, the correlation consistent family of Gaussian basis sets has been expanded to include all-electron basis sets for In–Xe. The methodology for developing these basis sets is described, and several examples of the performance and utility of the new sets have been provided. Dissociation energies and bond lengths for both homonuclear and heteronuclear diatomics demonstrate the systematic convergence behavior with respect to increasing basis set quality expected by the family of correlation consistent basis sets in describing molecular properties. Comparison with recently developed correlation consistent sets designed for use with the Douglas-Kroll Hamiltonian is provided.

Initial data sets for the Schwarzschild spacetime

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gomez-Lobo, Alfonso Garcia-Parrado; Kroon, Juan A. Valiente; School of Mathematical Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS

2007-01-15

A characterization of initial data sets for the Schwarzschild spacetime is provided. This characterization is obtained by performing a 3+1 decomposition of a certain invariant characterization of the Schwarzschild spacetime given in terms of concomitants of the Weyl tensor. This procedure renders a set of necessary conditions--which can be written in terms of the electric and magnetic parts of the Weyl tensor and their concomitants--for an initial data set to be a Schwarzschild initial data set. Our approach also provides a formula for a static Killing initial data set candidate--a KID candidate. Sufficient conditions for an initial data set tomore » be a Schwarzschild initial data set are obtained by supplementing the necessary conditions with the requirement that the initial data set possesses a stationary Killing initial data set of the form given by our KID candidate. Thus, we obtain an algorithmic procedure of checking whether a given initial data set is Schwarzschildean or not.« less

ON A GENERALIZED SELF-SIMILARITY IN THE p-ADIC FIELD

NASA Astrophysics Data System (ADS)

Mukhamedov, Farrukh; Khakimov, Otabek

2016-08-01

In the present paper, we introduce a new set which defines a generalized self-similar set for contractive functions {fi}i=1N on the unit ball ℤp of p-adic numbers. This set is called unconventional limit set. We prove that the unconventional limit set is compact, perfect and uniformly disconnected. Moreover, we provide an example of two contractions for which the corresponding unconventional limiting set is quasi-symmetrically equivalent to the symbolic Cantor set.

Rate My Attitude: Research Agendas and RateMyProfessor Scores

ERIC Educational Resources Information Center

Carlozzi, Michael

2018-01-01

The literature on student evaluations of teaching (SETs) generally presents two opposing camps: those who believe in the validity and usefulness of SETs, and those who do not. Some researchers have suggested that 'SET deniers' resist SETs because of their own poor SET results. To test this hypothesis, I analysed essays by 230 SET researchers (170…

Cone beam CT-based set-up strategies with and without rotational correction for stereotactic body radiation therapy in the liver.

PubMed

Bertholet, Jenny; Worm, Esben; Høyer, Morten; Poulsen, Per

2017-06-01

Accurate patient positioning is crucial in stereotactic body radiation therapy (SBRT) due to a high dose regimen. Cone-beam computed tomography (CBCT) is often used for patient positioning based on radio-opaque markers. We compared six CBCT-based set-up strategies with or without rotational correction. Twenty-nine patients with three implanted markers received 3-6 fraction liver SBRT. The markers were delineated on the mid-ventilation phase of a 4D-planning-CT. One pretreatment CBCT was acquired per fraction. Set-up strategy 1 used only translational correction based on manual marker match between the CBCT and planning CT. Set-up strategy 2 used automatic 6 degrees-of-freedom registration of the vertebrae closest to the target. The 3D marker trajectories were also extracted from the projections and the mean position of each marker was calculated and used for set-up strategies 3-6. Translational correction only was used for strategy 3. Translational and rotational corrections were used for strategies 4-6 with the rotation being either vertebrae based (strategy 4), or marker based and constrained to ±3° (strategy 5) or unconstrained (strategy 6). The resulting set-up error was calculated as the 3D root-mean-square set-up error of the three markers. The set-up error of the spinal cord was calculated for all strategies. The bony anatomy set-up (2) had the largest set-up error (5.8 mm). The marker-based set-up with unconstrained rotations (6) had the smallest set-up error (0.8 mm) but the largest spinal cord set-up error (12.1 mm). The marker-based set-up with translational correction only (3) or with bony anatomy rotational correction (4) had equivalent set-up error (1.3 mm) but rotational correction reduced the spinal cord set-up error from 4.1 mm to 3.5 mm. Marker-based set-up was substantially better than bony-anatomy set-up. Rotational correction may improve the set-up, but further investigations are required to determine the optimal correction strategy.

Radial sets: interactive visual analysis of large overlapping sets.

PubMed

Alsallakh, Bilal; Aigner, Wolfgang; Miksch, Silvia; Hauser, Helwig

2013-12-01

In many applications, data tables contain multi-valued attributes that often store the memberships of the table entities to multiple sets such as which languages a person masters, which skills an applicant documents, or which features a product comes with. With a growing number of entities, the resulting element-set membership matrix becomes very rich of information about how these sets overlap. Many analysis tasks targeted at set-typed data are concerned with these overlaps as salient features of such data. This paper presents Radial Sets, a novel visual technique to analyze set memberships for a large number of elements. Our technique uses frequency-based representations to enable quickly finding and analyzing different kinds of overlaps between the sets, and relating these overlaps to other attributes of the table entities. Furthermore, it enables various interactions to select elements of interest, find out if they are over-represented in specific sets or overlaps, and if they exhibit a different distribution for a specific attribute compared to the rest of the elements. These interactions allow formulating highly-expressive visual queries on the elements in terms of their set memberships and attribute values. As we demonstrate via two usage scenarios, Radial Sets enable revealing and analyzing a multitude of overlapping patterns between large sets, beyond the limits of state-of-the-art techniques.

Comparison of taxon-specific versus general locus sets for targeted sequence capture in plant phylogenomics.

PubMed

Chau, John H; Rahfeldt, Wolfgang A; Olmstead, Richard G

2018-03-01

Targeted sequence capture can be used to efficiently gather sequence data for large numbers of loci, such as single-copy nuclear loci. Most published studies in plants have used taxon-specific locus sets developed individually for a clade using multiple genomic and transcriptomic resources. General locus sets can also be developed from loci that have been identified as single-copy and have orthologs in large clades of plants. We identify and compare a taxon-specific locus set and three general locus sets (conserved ortholog set [COSII], shared single-copy nuclear [APVO SSC] genes, and pentatricopeptide repeat [PPR] genes) for targeted sequence capture in Buddleja (Scrophulariaceae) and outgroups. We evaluate their performance in terms of assembly success, sequence variability, and resolution and support of inferred phylogenetic trees. The taxon-specific locus set had the most target loci. Assembly success was high for all locus sets in Buddleja samples. For outgroups, general locus sets had greater assembly success. Taxon-specific and PPR loci had the highest average variability. The taxon-specific data set produced the best-supported tree, but all data sets showed improved resolution over previous non-sequence capture data sets. General locus sets can be a useful source of sequence capture targets, especially if multiple genomic resources are not available for a taxon.

Orthogonal Invariant Sets of the Diffusion Tensor and the Development of a Curvilinear Set Suitable for Low-Anisotropy Tissues

PubMed Central

Damion, Robin A.; Radjenovic, Aleksandra; Ingham, Eileen; Jin, Zhongmin; Ries, Michael E.

2013-01-01

We develop a curvilinear invariant set of the diffusion tensor which may be applied to Diffusion Tensor Imaging measurements on tissues and porous media. This new set is an alternative to the more common invariants such as fractional anisotropy and the diffusion mode. The alternative invariant set possesses a different structure to the other known invariant sets; the second and third members of the curvilinear set measure the degree of orthotropy and oblateness/prolateness, respectively. The proposed advantage of these invariants is that they may work well in situations of low diffusion anisotropy and isotropy, as is often observed in tissues such as cartilage. We also explore the other orthogonal invariant sets in terms of their geometry in relation to eigenvalue space; a cylindrical set, a spherical set (including fractional anisotropy and the mode), and a log-Euclidean set. These three sets have a common structure. The first invariant measures the magnitude of the diffusion, the second and third invariants capture aspects of the anisotropy; the magnitude of the anisotropy and the shape of the diffusion ellipsoid (the manner in which the anisotropy is realised). We also show a simple method to prove the orthogonality of the invariants within a set. PMID:24244366

Setting research priorities by applying the combined approach matrix.

PubMed

Ghaffar, Abdul

2009-04-01

Priority setting in health research is a dynamic process. Different organizations and institutes have been working in the field of research priority setting for many years. In 1999 the Global Forum for Health Research presented a research priority setting tool called the Combined Approach Matrix or CAM. Since its development, the CAM has been successfully applied to set research priorities for diseases, conditions and programmes at global, regional and national levels. This paper briefly explains the CAM methodology and how it could be applied in different settings, giving examples and describing challenges encountered in the process of setting research priorities and providing recommendations for further work in this field. The construct and design of the CAM is explained along with different steps needed, including planning and organization of a priority-setting exercise and how it could be applied in different settings. The application of the CAM are described by using three examples. The first concerns setting research priorities for a global programme, the second describes application at the country level and the third setting research priorities for diseases. Effective application of the CAM in different and diverse environments proves its utility as a tool for setting research priorities. Potential challenges encountered in the process of research priority setting are discussed and some recommendations for further work in this field are provided.

Dissociating Stimulus-Set and Response-Set in the Context of Task-Set Switching

PubMed Central

Kieffaber, Paul D.; Kruschke, John K.; Cho, Raymond Y.; Walker, Philip M.; Hetrick, William P.

2014-01-01

The primary aim of the present research was to determine how stimulus-set and response-set components of task-set contribute to switch costs and conflict processing. Three experiments are described wherein participants completed an explicitly cued task-switching procedure. Experiment 1 established that task switches requiring a reconfiguration of both stimulus- and response-set incurred larger residual switch costs than task switches requiring the reconfiguration of stimulus-set alone. Between-task interference was also drastically reduced for response-set conflict compared with stimulus-set conflict. A second experiment replicated these findings and demonstrated that stimulus- and response-conflict have dissociable effects on the “decision time” and “motor time” components of total response time. Finally, a third experiment replicated Experiment 2 and demonstrated that the stimulus- and response- components of task switching and conflict processing elicit dissociable neural activity as evidence by event-related brain potentials. PMID:22984990

Goal setting: an integral component of effective diabetes care.

PubMed

Miller, Carla K; Bauman, Jennifer

2014-08-01

Goal setting is a widely used behavior change tool in diabetes education and training. Prior research found specific relatively difficult but attainable goals set within a specific timeframe improved performance in sports and at the workplace. However, the impact of goal setting in diabetes self-care has not received extensive attention. This review examined the mechanisms underlying behavioral change according to goal setting theory and evaluated the impact of goal setting in diabetes intervention studies. Eight studies were identified, which incorporated goal setting as the primary strategy to promote behavioral change in individual, group-based, and primary care settings among patients with type 2 diabetes. Improvements in diabetes-related self-efficacy, dietary intake, physical activity, and A1c were observed in some but not all studies. More systematic research is needed to determine the conditions and behaviors for which goal setting is most effective. Initial recommendations for using goal setting in diabetes patient encounters are offered.

Correcting Evaluation Bias of Relational Classifiers with Network Cross Validation

DTIC Science & Technology

2010-01-01

classi- fication algorithms: simple random resampling (RRS), equal-instance random resampling (ERS), and network cross-validation ( NCV ). The first two... NCV procedure that eliminates overlap between test sets altogether. The procedure samples for k disjoint test sets that will be used for evaluation...propLabeled ∗ S) nodes from train Pool in f erenceSet =network − trainSet F = F ∪ < trainSet, test Set, in f erenceSet > end for output: F NCV addresses

Single versus multiple sets of resistance exercise: a meta-regression.

PubMed

Krieger, James W

2009-09-01

There has been considerable debate over the optimal number of sets per exercise to improve musculoskeletal strength during a resistance exercise program. The purpose of this study was to use hierarchical, random-effects meta-regression to compare the effects of single and multiple sets per exercise on dynamic strength. English-language studies comparing single with multiple sets per exercise, while controlling for other variables, were considered eligible for inclusion. The analysis comprised 92 effect sizes (ESs) nested within 30 treatment groups and 14 studies. Multiple sets were associated with a larger ES than a single set (difference = 0.26 +/- 0.05; confidence interval [CI]: 0.15, 0.37; p < 0.0001). In a dose-response model, 2 to 3 sets per exercise were associated with a significantly greater ES than 1 set (difference = 0.25 +/- 0.06; CI: 0.14, 0.37; p = 0.0001). There was no significant difference between 1 set per exercise and 4 to 6 sets per exercise (difference = 0.35 +/- 0.25; CI: -0.05, 0.74; p = 0.17) or between 2 to 3 sets per exercise and 4 to 6 sets per exercise (difference = 0.09 +/- 0.20; CI: -0.31, 0.50; p = 0.64). There were no interactions between set volume and training program duration, subject training status, or whether the upper or lower body was trained. Sensitivity analysis revealed no highly influential studies, and no evidence of publication bias was observed. In conclusion, 2 to 3 sets per exercise are associated with 46% greater strength gains than 1 set, in both trained and untrained subjects.

Down-weighting overlapping genes improves gene set analysis

PubMed Central

2012-01-01

Background The identification of gene sets that are significantly impacted in a given condition based on microarray data is a crucial step in current life science research. Most gene set analysis methods treat genes equally, regardless how specific they are to a given gene set. Results In this work we propose a new gene set analysis method that computes a gene set score as the mean of absolute values of weighted moderated gene t-scores. The gene weights are designed to emphasize the genes appearing in few gene sets, versus genes that appear in many gene sets. We demonstrate the usefulness of the method when analyzing gene sets that correspond to the KEGG pathways, and hence we called our method Pathway Analysis with Down-weighting of Overlapping Genes (PADOG). Unlike most gene set analysis methods which are validated through the analysis of 2-3 data sets followed by a human interpretation of the results, the validation employed here uses 24 different data sets and a completely objective assessment scheme that makes minimal assumptions and eliminates the need for possibly biased human assessments of the analysis results. Conclusions PADOG significantly improves gene set ranking and boosts sensitivity of analysis using information already available in the gene expression profiles and the collection of gene sets to be analyzed. The advantages of PADOG over other existing approaches are shown to be stable to changes in the database of gene sets to be analyzed. PADOG was implemented as an R package available at: http://bioinformaticsprb.med.wayne.edu/PADOG/or http://www.bioconductor.org. PMID:22713124

78 FR 36496 - International Fisheries; Western and Central Pacific Fisheries for Highly Migratory Species...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-18

... number of vessels that engaged in both deep-setting and shallow-setting ranged from 17 to 35. The number... shallow-set and deep-set longlining. Based on an average of 127 active vessels during that period, the... analyses prepared for the 2009 rule are: (3) Shallow-set longline fishing for swordfish (for deep-setting...

Construction of Weak and Strong Similarity Measures for Ordered Sets of Documents Using Fuzzy Set Techniques.

ERIC Educational Resources Information Center

Egghe, L.; Michel, C.

2003-01-01

Ordered sets (OS) of documents are encountered more and more in information distribution systems, such as information retrieval systems. Classical similarity measures for ordinary sets of documents need to be extended to these ordered sets. This is done in this article using fuzzy set techniques. The practical usability of the OS-measures is…

The Effect of Distributed Practice in Undergraduate Statistics Homework Sets: A Randomized Trial

ERIC Educational Resources Information Center

Crissinger, Bryan R.

2015-01-01

Most homework sets in statistics courses are constructed so that students concentrate or "mass" their practice on a certain topic in one problem set. Distributed practice homework sets include review problems in each set so that practice on a topic is distributed across problem sets. There is a body of research that points to the…

Basis sets for the calculation of core-electron binding energies

NASA Astrophysics Data System (ADS)

Hanson-Heine, Magnus W. D.; George, Michael W.; Besley, Nicholas A.

2018-05-01

Core-electron binding energies (CEBEs) computed within a Δ self-consistent field approach require large basis sets to achieve convergence with respect to the basis set limit. It is shown that supplementing a basis set with basis functions from the corresponding basis set for the element with the next highest nuclear charge (Z + 1) provides basis sets that give CEBEs close to the basis set limit. This simple procedure provides relatively small basis sets that are well suited for calculations where the description of a core-ionised state is important, such as time-dependent density functional theory calculations of X-ray emission spectroscopy.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Papajak, Ewa; Truhlar, Donald G.

We present sets of convergent, partially augmented basis set levels corresponding to subsets of the augmented “aug-cc-pV(n+d)Z” basis sets of Dunning and co-workers. We show that for many molecular properties a basis set fully augmented with diffuse functions is computationally expensive and almost always unnecessary. On the other hand, unaugmented cc-pV(n+d)Z basis sets are insufficient for many properties that require diffuse functions. Therefore, we propose using intermediate basis sets. We developed an efficient strategy for partial augmentation, and in this article, we test it and validate it. Sequentially deleting diffuse basis functions from the “aug” basis sets yields the “jul”,more » “jun”, “may”, “apr”, etc. basis sets. Tests of these basis sets for Møller-Plesset second-order perturbation theory (MP2) show the advantages of using these partially augmented basis sets and allow us to recommend which basis sets offer the best accuracy for a given number of basis functions for calculations on large systems. Similar truncations in the diffuse space can be performed for the aug-cc-pVxZ, aug-cc-pCVxZ, etc. basis sets.« less

Toward the International Classification of Functioning, Disability and Health (ICF) Rehabilitation Set: A Minimal Generic Set of Domains for Rehabilitation as a Health Strategy.

PubMed

Prodinger, Birgit; Cieza, Alarcos; Oberhauser, Cornelia; Bickenbach, Jerome; Üstün, Tevfik Bedirhan; Chatterji, Somnath; Stucki, Gerold

2016-06-01

To develop a comprehensive set of the International Classification of Functioning, Disability and Health (ICF) categories as a minimal standard for reporting and assessing functioning and disability in clinical populations along the continuum of care. The specific aims were to specify the domains of functioning recommended for an ICF Rehabilitation Set and to identify a minimal set of environmental factors (EFs) to be used alongside the ICF Rehabilitation Set when describing disability across individuals and populations with various health conditions. Secondary analysis of existing data sets using regression methods (Random Forests and Group Lasso regression) and expert consultations. Along the continuum of care, including acute, early postacute, and long-term and community rehabilitation settings. Persons (N=9863) with various health conditions participated in primary studies. The number of respondents for whom the dependent variable data were available and used in this analysis was 9264. Not applicable. For regression analyses, self-reported general health was used as a dependent variable. The ICF categories from the functioning component and the EF component were used as independent variables for the development of the ICF Rehabilitation Set and the minimal set of EFs, respectively. Thirty ICF categories to be complemented with 12 EFs were identified as relevant to the identified ICF sets. The ICF Rehabilitation Set constitutes of 9 ICF categories from the component body functions and 21 from the component activities and participation. The minimal set of EFs contains 12 categories spanning all chapters of the EF component of the ICF. The identified sets proposed serve as minimal generic sets of aspects of functioning in clinical populations for reporting data within and across heath conditions, time, clinical settings including rehabilitation, and countries. These sets present a reference framework for harmonizing existing information on disability across general and clinical populations. Copyright © 2016 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

Optical add/drop filter for wavelength division multiplexed systems

DOEpatents

Deri, Robert J.; Strand, Oliver T.; Garrett, Henry E.

2002-01-01

An optical add/drop filter for wavelength division multiplexed systems and construction methods are disclosed. The add/drop filter includes a first ferrule having a first pre-formed opening for receiving a first optical fiber; an interference filter oriented to pass a first set of wavelengths along the first optical fiber and reflect a second set of wavelengths; and, a second ferrule having a second pre-formed opening for receiving the second optical fiber, and the reflected second set of wavelengths. A method for constructing the optical add/drop filter consists of the steps of forming a first set of openings in a first ferrule; inserting a first set of optical fibers into the first set of openings; forming a first set of guide pin openings in the first ferrule; dividing the first ferrule into a first ferrule portion and a second ferrule portion; forming an interference filter on the first ferrule portion; inserting guide pins through the first set of guide pin openings in the first ferrule portion and second ferrule portion to passively align the first set of optical fibers; removing material such that light reflected from the interference filter from the first set of optical fibers is accessible; forming a second set of openings in a second ferrule; inserting a second set of optical fibers into the second set of openings; and positioning the second ferrule with respect to the first ferrule such that the second set of optical fibers receive the light reflected from the interference filter.

42 CFR 415.150 - Scope.

Code of Federal Regulations, 2010 CFR

2010-10-01

... PROGRAM SERVICES FURNISHED BY PHYSICIANS IN PROVIDERS, SUPERVISING PHYSICIANS IN TEACHING SETTINGS, AND RESIDENTS IN CERTAIN SETTINGS Physician Services in Teaching Settings § 415.150 Scope. This subpart sets forth the rules governing payment for the services of physicians in teaching settings and the criteria...

On Fuzzy Sets and Rough Sets from the Perspective of Indiscernibility

NASA Astrophysics Data System (ADS)

Chakraborty, Mihir K.

The category theoretic approach of Obtułowicz to Pawlak's rough sets has been reintroduced in a somewhat modified form. A generalization is rendered to this approach that has been motivated by the notion of rough membership function. Thus, a link is established between rough sets and L-fuzzy sets for some special lattices. It is shown that a notion of indistinguishability lies at the root of vagueness. This observation in turn gives a common ground to the theories of rough sets and fuzzy sets.

Why Is 10 Past 10 the Default Setting for Clocks and Watches in Advertisements? A Psychological Experiment.

PubMed

Karim, Ahmed A; Lützenkirchen, Britta; Khedr, Eman; Khalil, Radwa

2017-01-01

Have you ever noticed that in watch advertisements the time is usually set at 10:10? The reasons and psychological effects of this default time setting are elusive. In Experiment 1, we hypothesized that watches showing a time setting resembling a smiling face (10:10) would enhance emotional valence and intention to buy compared to a neutral time setting (11:30), whereas a time setting resembling a sad face (8:20) would have the opposite effect. Moreover, we investigated a possible interaction effect with the gender of the participants. In Experiment 2, we directly tested the hypotheses that watches set at 10:10 resemble a smiling face, whereas watches set at 8:20 resemble a sad face. The data of the first experiment reveal that watches set at 10:10 showed a significant positive effect on the emotion of the observer and the intention to buy. However, watches set at 8:20 did not show any effect on the emotion or the intention to buy. Moreover, watches set at 10:10 induced in women significantly stronger ratings of pleasure than in men. The data of the second experiment show that participants consistently perceive high resemblance between watches set at 10:10 and a smiling face as well as high resemblance between watches set at 8:20 and a sad face. This study provides for the first time empirical evidence for the notion that using watches with a time setting resembling a smiling face (like 10:10) can positively affect the emotional response of the observers and their evaluation of a seen watch, even though they are not aware of the fact that the shown time setting is inducing this effect. Practical implications of the observed findings and alternative explanations are discussed.

The Effect of Rest Interval Length on Repetition Consistency and Perceived Exertion During Near Maximal Loaded Bench Press Sets.

PubMed

Scudese, Estevão; Willardson, Jeffrey M; Simão, Roberto; Senna, Gilmar; de Salles, Belmiro F; Miranda, Humberto

2015-11-01

The purpose of this study was to compare different rest intervals between sets on repetition consistency and ratings of perceived exertion (RPE) during consecutive bench press sets with an absolute 3RM (3 repetition maximum) load. Sixteen trained men (23.75 ± 4.21 years; 74.63 ± 5.36 kg; 175 ± 4.64 cm; bench press relative strength: 1.44 ± 0.19 kg/kg of body mass) attended 4 randomly ordered sessions during which 5 consecutive sets of the bench press were performed with an absolute 3RM load and 1, 2, 3, or 5 minutes of rest interval between sets. The results indicated that significantly greater bench press repetitions were completed with 2, 3, and 5 minutes vs. 1-minute rest between sets (p ≤ 0.05); no significant differences were noted between the 2, 3, and 5 minutes rest conditions. For the 1-minute rest condition, performance reductions (relative to the first set) were observed commencing with the second set; whereas for the other conditions (2, 3, and 5 minutes rest), performance reductions were not evident until the third and fourth sets. The RPE values before each of the successive sets were significantly greater, commencing with the second set for the 1-minute vs. the 3 and 5 minutes rest conditions. Significant increases were also evident in RPE immediately after each set between the 1 and 5 minutes rest conditions from the second through fifth sets. These findings indicate that when utilizing an absolute 3RM load for the bench press, practitioners may prescribe a time-efficient minimum of 2 minutes rest between sets without significant impairments in repetition performance. However, lower perceived exertion levels may necessitate prescription of a minimum of 3 minutes rest between sets.

Efficient Algorithms for Segmentation of Item-Set Time Series

NASA Astrophysics Data System (ADS)

Chundi, Parvathi; Rosenkrantz, Daniel J.

We propose a special type of time series, which we call an item-set time series, to facilitate the temporal analysis of software version histories, email logs, stock market data, etc. In an item-set time series, each observed data value is a set of discrete items. We formalize the concept of an item-set time series and present efficient algorithms for segmenting a given item-set time series. Segmentation of a time series partitions the time series into a sequence of segments where each segment is constructed by combining consecutive time points of the time series. Each segment is associated with an item set that is computed from the item sets of the time points in that segment, using a function which we call a measure function. We then define a concept called the segment difference, which measures the difference between the item set of a segment and the item sets of the time points in that segment. The segment difference values are required to construct an optimal segmentation of the time series. We describe novel and efficient algorithms to compute segment difference values for each of the measure functions described in the paper. We outline a dynamic programming based scheme to construct an optimal segmentation of the given item-set time series. We use the item-set time series segmentation techniques to analyze the temporal content of three different data sets—Enron email, stock market data, and a synthetic data set. The experimental results show that an optimal segmentation of item-set time series data captures much more temporal content than a segmentation constructed based on the number of time points in each segment, without examining the item set data at the time points, and can be used to analyze different types of temporal data.

A Comparison of EQ-5D-3L Index Scores Using Malaysian, Singaporean, Thai, and UK Value Sets in Indonesian Cervical Cancer Patients.

PubMed

Endarti, Dwi; Riewpaiboon, Arthorn; Thavorncharoensap, Montarat; Praditsitthikorn, Naiyana; Hutubessy, Raymond; Kristina, Susi Ari

2018-05-01

To gain insight into the most suitable foreign value set among Malaysian, Singaporean, Thai, and UK value sets for calculating the EuroQol five-dimensional questionnaire index score (utility) among patients with cervical cancer in Indonesia. Data from 87 patients with cervical cancer recruited from a referral hospital in Yogyakarta province, Indonesia, from an earlier study of health-related quality of life were used in this study. The differences among the utility scores derived from the four value sets were determined using the Friedman test. Performance of the psychometric properties of the four value sets versus visual analogue scale (VAS) was assessed. Intraclass correlation coefficients and Bland-Altman plots were used to test the agreement among the utility scores. Spearman ρ correlation coefficients were used to assess convergent validity between utility scores and patients' sociodemographic and clinical characteristics. With respect to known-group validity, the Kruskal-Wallis test was used to examine the differences in utility according to the stages of cancer. There was significant difference among utility scores derived from the four value sets, among which the Malaysian value set yielded higher utility than the other three value sets. Utility obtained from the Malaysian value set had more agreements with VAS than the other value sets versus VAS (intraclass correlation coefficients and Bland-Altman plot tests results). As for the validity, the four value sets showed equivalent psychometric properties as those that resulted from convergent and known-group validity tests. In the absence of an Indonesian value set, the Malaysian value set was more preferable to be used compared with the other value sets. Further studies on the development of an Indonesian value set need to be conducted. Copyright © 2018. Published by Elsevier Inc.

Why Is 10 Past 10 the Default Setting for Clocks and Watches in Advertisements? A Psychological Experiment

PubMed Central

Karim, Ahmed A.; Lützenkirchen, Britta; Khedr, Eman; Khalil, Radwa

2017-01-01

Have you ever noticed that in watch advertisements the time is usually set at 10:10? The reasons and psychological effects of this default time setting are elusive. In Experiment 1, we hypothesized that watches showing a time setting resembling a smiling face (10:10) would enhance emotional valence and intention to buy compared to a neutral time setting (11:30), whereas a time setting resembling a sad face (8:20) would have the opposite effect. Moreover, we investigated a possible interaction effect with the gender of the participants. In Experiment 2, we directly tested the hypotheses that watches set at 10:10 resemble a smiling face, whereas watches set at 8:20 resemble a sad face. The data of the first experiment reveal that watches set at 10:10 showed a significant positive effect on the emotion of the observer and the intention to buy. However, watches set at 8:20 did not show any effect on the emotion or the intention to buy. Moreover, watches set at 10:10 induced in women significantly stronger ratings of pleasure than in men. The data of the second experiment show that participants consistently perceive high resemblance between watches set at 10:10 and a smiling face as well as high resemblance between watches set at 8:20 and a sad face. This study provides for the first time empirical evidence for the notion that using watches with a time setting resembling a smiling face (like 10:10) can positively affect the emotional response of the observers and their evaluation of a seen watch, even though they are not aware of the fact that the shown time setting is inducing this effect. Practical implications of the observed findings and alternative explanations are discussed. PMID:28878709

Duration of Infusion Set Survival in Lipohypertrophy Versus Nonlipohypertrophied Tissue in Patients with Type 1 Diabetes

PubMed Central

Karlin, Andrew W.; Ly, Trang T.; Pyle, Laura; Forlenza, Gregory P.; Messer, Laurel; Wadwa, R. Paul; DeSalvo, Daniel J.; Payne, Sydney L.; Hanes, Sarah; Clinton, Paula; Buckingham, Bruce

2016-01-01

Abstract Background: Improved insulin infusion set survival and faster insulin action are important issues for pump users and for the development of an artificial pancreas. The current recommendation is to change infusion sets every 3 days. Our objectives were to determine the effect of lipohypertrophy (LH) on infusion set survival and continuous glucose monitoring glucose levels. Research Design and Methods: In this multicenter crossover trial, we recruited 20 subjects (age 28.1 ± 9.0 years) with type 1 diabetes (duration 17.5 ± 8.8 years) and an area of lipohypertrophied tissue >3 cm. Subjects alternated weekly wearing a Teflon infusion set in an area of either LH or non-LH for 4 weeks. Sets were changed after (a) failure or (b) surviving 7 days of use. Results: The least-squares mean duration of infusion set survival for sets that lasted <7 days in lipohypertrophied tissue was 4.31 days compared with 4.12 days in nonlipohypertrophied tissue (P = 0.71). The average duration of set survival for individual subjects ranged from 2.2 to 7.0 days. Infusion sets in lipohypertrophied tissue failed due to hyperglycemia in 35% of subjects compared with 23% in nonlipohypertrophied tissue (P = 0.22). Both lipohypertrophied and nonlipohypertrophied tissues displayed a general increase in mean daily glucose after the third day of infusion set wear, but daily mean glucose did not differ by tissue type (P > 0.38 on each day). Conclusion: LH did not significantly affect infusion set survival or mean glucose. Achieving optimal infusion set performance requires research into factors affecting set survival. Additionally, the recommendation for duration of set change may need to be individualized. PMID:27227290

Local, smooth, and consistent Jacobi set simplification

DOE PAGES

Bhatia, Harsh; Wang, Bei; Norgard, Gregory; ...

2014-10-31

The relation between two Morse functions defined on a smooth, compact, and orientable 2-manifold can be studied in terms of their Jacobi set. The Jacobi set contains points in the domain where the gradients of the two functions are aligned. Both the Jacobi set itself as well as the segmentation of the domain it induces, have shown to be useful in various applications. In practice, unfortunately, functions often contain noise and discretization artifacts, causing their Jacobi set to become unmanageably large and complex. Although there exist techniques to simplify Jacobi sets, they are unsuitable for most applications as they lackmore » fine-grained control over the process, and heavily restrict the type of simplifications possible. In this paper, we introduce a new framework that generalizes critical point cancellations in scalar functions to Jacobi set in two dimensions. We present a new interpretation of Jacobi set simplification based on the perspective of domain segmentation. Generalizing the cancellation of critical points from scalar functions to Jacobi sets, we focus on simplifications that can be realized by smooth approximations of the corresponding functions, and show how these cancellations imply simultaneous simplification of contiguous subsets of the Jacobi set. Using these extended cancellations as atomic operations, we introduce an algorithm to successively cancel subsets of the Jacobi set with minimal modifications to some user-defined metric. We show that for simply connected domains, our algorithm reduces a given Jacobi set to its minimal configuration, that is, one with no birth–death points (a birth–death point is a specific type of singularity within the Jacobi set where the level sets of the two functions and the Jacobi set have a common normal direction).« less

UpSetR: an R package for the visualization of intersecting sets and their properties.

PubMed

Conway, Jake R; Lex, Alexander; Gehlenborg, Nils

2017-09-15

Venn and Euler diagrams are a popular yet inadequate solution for quantitative visualization of set intersections. A scalable alternative to Venn and Euler diagrams for visualizing intersecting sets and their properties is needed. We developed UpSetR, an open source R package that employs a scalable matrix-based visualization to show intersections of sets, their size, and other properties. UpSetR is available at https://github.com/hms-dbmi/UpSetR/ and released under the MIT License. A Shiny app is available at https://gehlenborglab.shinyapps.io/upsetr/ . nils@hms.harvard.edu. Supplementary data are available at Bioinformatics online. © The Author(s) 2017. Published by Oxford University Press.

Part-set cueing impairment & facilitation in semantic memory.

PubMed

Kelley, Matthew R; Parihar, Sushmeena A

2018-01-19

The present study explored the influence of part-set cues in semantic memory using tests of "free" recall, reconstruction of order, and serial recall. Nine distinct categories of information were used (e.g., Zodiac signs, Harry Potter books, Star Wars films, planets). The results showed part-set cueing impairment for all three "free" recall sets, whereas part-set cueing facilitation was evident for five of the six ordered sets. Generally, the present results parallel those often observed across episodic tasks, which could indicate that similar mechanisms contribute to part-set cueing effects in both episodic and semantic memory. A novel anchoring explanation of part-set cueing facilitation in order and spatial tasks is provided.

Functional Multiple-Set Canonical Correlation Analysis

ERIC Educational Resources Information Center

Hwang, Heungsun; Jung, Kwanghee; Takane, Yoshio; Woodward, Todd S.

2012-01-01

We propose functional multiple-set canonical correlation analysis for exploring associations among multiple sets of functions. The proposed method includes functional canonical correlation analysis as a special case when only two sets of functions are considered. As in classical multiple-set canonical correlation analysis, computationally, the…

Setting priorities in health care organizations: criteria, processes, and parameters of success.

PubMed

Gibson, Jennifer L; Martin, Douglas K; Singer, Peter A

2004-09-08

Hospitals and regional health authorities must set priorities in the face of resource constraints. Decision-makers seek practical ways to set priorities fairly in strategic planning, but find limited guidance from the literature. Very little has been reported from the perspective of Board members and senior managers about what criteria, processes and parameters of success they would use to set priorities fairly. We facilitated workshops for board members and senior leadership at three health care organizations to assist them in developing a strategy for fair priority setting. Workshop participants identified 8 priority setting criteria, 10 key priority setting process elements, and 6 parameters of success that they would use to set priorities in their organizations. Decision-makers in other organizations can draw lessons from these findings to enhance the fairness of their priority setting decision-making. Lessons learned in three workshops fill an important gap in the literature about what criteria, processes, and parameters of success Board members and senior managers would use to set priorities fairly.

Can the identity of a behavior setting be perceived through patterns of joint action? An investigation of place perception.

PubMed

Heft, Harry; Hoch, Justine; Edmunds, Trent; Weeks, Jillian

2014-10-13

"Behavior settings" are generated by joint actions of individuals in conjunction with the milieu features (or affordances) that are available. The reported research explores the hypothesis that the identity or meaning of a behavior setting can be perceived by means of the patterns of action collectively generated by the setting's participants. A set of computer animations was created based on detailed observation of activities in everyday settings. Three experiments were conducted to assess whether perceivers could extract "structure from motion" (in this case, collective actions) that was specific to the particular behavior setting displayed by way of the animations. Two experiments assessed whether individuals could accurately perceive the identity of the behavior settings with such displays, and a third experiment indirectly examined this possibility by evaluating whether setting possibilities and constraints were recognized. The results offered some support for the hypothesis, and suggested several refinements in how to conceptualize a typology of behavior settings. An ecological approach to place perception is also discussed.

Central On-Line Data Directory

NASA Technical Reports Server (NTRS)

Thieman, J.

1986-01-01

The National Space Science Data Center (NSSDC) Central On-Line Data Directory (CODD), which allows the general scientist remote access to information about data sets available not only at NSSDC, but throughout the scientific community, is discussed. A user may search for data set information within CODD by specifying spacecraft name, experiment name, investigator name, and/or keywords. CODD will include information on atmospheric science data sets contained not only within the PCDS, but also within other data sets that are deemed important. Keywords to be used in locating these data sets are currently being formulated. The main type of keyword to be used for categorization of data sets will be discipline related. The primary discipline keyword for PCDS-type data sets would be ATMOSPHERIC SCIENCE. A good set of subdiscipline keywords is needed under this discipline to subdivide the data sets. A sheet containing a strawman set of subdiscipline keywords was distributed, and a request was made for the knowledgeable scientists to modify or replace the proposed keywords.

The Molecular Signatures Database (MSigDB) hallmark gene set collection.

PubMed

Liberzon, Arthur; Birger, Chet; Thorvaldsdóttir, Helga; Ghandi, Mahmoud; Mesirov, Jill P; Tamayo, Pablo

2015-12-23

The Molecular Signatures Database (MSigDB) is one of the most widely used and comprehensive databases of gene sets for performing gene set enrichment analysis. Since its creation, MSigDB has grown beyond its roots in metabolic disease and cancer to include >10,000 gene sets. These better represent a wider range of biological processes and diseases, but the utility of the database is reduced by increased redundancy across, and heterogeneity within, gene sets. To address this challenge, here we use a combination of automated approaches and expert curation to develop a collection of "hallmark" gene sets as part of MSigDB. Each hallmark in this collection consists of a "refined" gene set, derived from multiple "founder" sets, that conveys a specific biological state or process and displays coherent expression. The hallmarks effectively summarize most of the relevant information of the original founder sets and, by reducing both variation and redundancy, provide more refined and concise inputs for gene set enrichment analysis.

Set Shifting Among Adolescents with Anorexia Nervosa

PubMed Central

Fitzpatrick, Kathleen Kara; Darcy, Alison; Colborn, Danielle; Gudorf, Caroline; Lock, James

2012-01-01

Objective Set shifting difficulties are documented for adults with anorexia nervosa (AN). However, AN typically onsets in adolescents and it is unclear if set-shifting difficulties are a result of chronic AN or present earlier in its course. This study examined whether adolescents with short duration AN demonstrated set shifting difficulties compared to healthy controls (HC). Method Data on set shifting collected from the Delis-Kaplan Executive Functioning System (DKEFS) and Wisconsin Card Sort Task (WCST) as well as eating psychopathology were collected from 32 adolescent inpatients with AN and compared to those from 22 HCs. Results There were no differences in set-shifting in adolescents with AN compared to HCs on most measures. Conclusion The findings suggest that set-shifting difficulties in AN may be a consequence of AN. Future studies should explore set-shifting difficulties in a larger sample of adolescents with the AN to determine if there is sub-set of adolescents with these difficulties and determine any relationship of set-shifting to the development of a chronic from of AN. PMID:22692985

Pre-coding method and apparatus for multiple source or time-shifted single source data and corresponding inverse post-decoding method and apparatus

NASA Technical Reports Server (NTRS)

Yeh, Pen-Shu (Inventor)

1997-01-01

A pre-coding method and device for improving data compression performance by removing correlation between a first original data set and a second original data set, each having M members, respectively. The pre-coding method produces a compression-efficiency-enhancing double-difference data set. The method and device produce a double-difference data set, i.e., an adjacent-delta calculation performed on a cross-delta data set or a cross-delta calculation performed on two adjacent-delta data sets, from either one of (1) two adjacent spectral bands coming from two discrete sources, respectively, or (2) two time-shifted data sets coming from a single source. The resulting double-difference data set is then coded using either a distortionless data encoding scheme (entropy encoding) or a lossy data compression scheme. Also, a post-decoding method and device for recovering a second original data set having been represented by such a double-difference data set.

Pre-coding method and apparatus for multiple source or time-shifted single source data and corresponding inverse post-decoding method and apparatus

NASA Technical Reports Server (NTRS)

Yeh, Pen-Shu (Inventor)

1998-01-01

A pre-coding method and device for improving data compression performance by removing correlation between a first original data set and a second original data set, each having M members, respectively. The pre-coding method produces a compression-efficiency-enhancing double-difference data set. The method and device produce a double-difference data set, i.e., an adjacent-delta calculation performed on a cross-delta data set or a cross-delta calculation performed on two adjacent-delta data sets, from either one of (1) two adjacent spectral bands coming from two discrete sources, respectively, or (2) two time-shifted data sets coming from a single source. The resulting double-difference data set is then coded using either a distortionless data encoding scheme (entropy encoding) or a lossy data compression scheme. Also, a post-decoding method and device for recovering a second original data set having been represented by such a double-difference data set.

NASIS data base management system - IBM 360/370 OS MVT implementation. 3: Data set specifications

NASA Technical Reports Server (NTRS)

1973-01-01

The data set specifications for the NASA Aerospace Safety Information System (NASIS) are presented. The data set specifications describe the content, format, and medium of communication of every data set required by the system. All relevant information pertinent to a particular set is prepared in a standard form and centralized in a single document. The format for the data set is provided.

NASIS data base management system: IBM 360 TSS implementation. Volume 3: Data set specifications

NASA Technical Reports Server (NTRS)

1973-01-01

The data set specifications for the NASA Aerospace Safety Information System (NASIS) are presented. The data set specifications describe the content, format, and medium of communication of every data set required by the system. All relevant information pertinent to a particular data set is prepared in a standard form and centralized in a single document. The format for the data set is provided.

What Predicts Children's Fixed and Growth Intelligence Mind-Sets? Not Their Parents' Views of Intelligence but Their Parents' Views of Failure.

PubMed

Haimovitz, Kyla; Dweck, Carol S

2016-06-01

Children's intelligence mind-sets (i.e., their beliefs about whether intelligence is fixed or malleable) robustly influence their motivation and learning. Yet, surprisingly, research has not linked parents' intelligence mind-sets to their children's. We tested the hypothesis that a different belief of parents-their failure mind-sets-may be more visible to children and therefore more prominent in shaping their beliefs. In Study 1, we found that parents can view failure as debilitating or enhancing, and that these failure mind-sets predict parenting practices and, in turn, children's intelligence mind-sets. Study 2 probed more deeply into how parents display failure mind-sets. In Study 3a, we found that children can indeed accurately perceive their parents' failure mind-sets but not their parents' intelligence mind-sets. Study 3b showed that children's perceptions of their parents' failure mind-sets also predicted their own intelligence mind-sets. Finally, Study 4 showed a causal effect of parents' failure mind-sets on their responses to their children's hypothetical failure. Overall, parents who see failure as debilitating focus on their children's performance and ability rather than on their children's learning, and their children, in turn, tend to believe that intelligence is fixed rather than malleable. © The Author(s) 2016.

Stable SET knockdown in breast cell carcinoma inhibits cell migration and invasion

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Jie; Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Center for Disease Control and Prevention, Shenzhen; Yang, Xi-fei

2014-10-10

Highlights: • We employed RNA interference to knockdown SET expression in breast cancer cells. • Knockdown of SET expression inhibits cell proliferation, migration and invasion. • Knockdown of SET expression increases the activity and expression of PP2A. • Knockdown of SET expression decreases the expression of MMP-9. - Abstract: Breast cancer is the most malignant tumor for women, however, the mechanisms underlying this devastating disease remain unclear. SET is an endogenous inhibitor of protein phosphatase 2A (PP2A) and involved in many physiological and pathological processes. SET could promote the occurrence of tumor through inhibiting PP2A. In this study, we exploremore » the role of SET in the migration and invasion of breast cancer cells MDA-MB-231 and ZR-75-30. The stable suppression of SET expression through lentivirus-mediated RNA interference (RNAi) was shown to inhibit the growth, migration and invasion of breast cancer cells. Knockdown of SET increases the activity and expression of PP2Ac and decrease the expression of matrix metalloproteinase 9 (MMP-9). These data demonstrate that SET may be involved in the pathogenic processes of breast cancer, indicating that SET can serve as a potential therapeutic target for the treatment of breast cancer.« less

Detection of explosive cough events in audio recordings by internal sound analysis.

PubMed

Rocha, B M; Mendes, L; Couceiro, R; Henriques, J; Carvalho, P; Paiva, R P

2017-07-01

We present a new method for the discrimination of explosive cough events, which is based on a combination of spectral content descriptors and pitch-related features. After the removal of near-silent segments, a vector of event boundaries is obtained and a proposed set of 9 features is extracted for each event. Two data sets, recorded using electronic stethoscopes and comprising a total of 46 healthy subjects and 13 patients, were employed to evaluate the method. The proposed feature set is compared to three other sets of descriptors: a baseline, a combination of both sets, and an automatic selection of the best 10 features from both sets. The combined feature set yields good results on the cross-validated database, attaining a sensitivity of 92.3±2.3% and a specificity of 84.7±3.3%. Besides, this feature set seems to generalize well when it is trained on a small data set of patients, with a variety of respiratory and cardiovascular diseases, and tested on a bigger data set of mostly healthy subjects: a sensitivity of 93.4% and a specificity of 83.4% are achieved in those conditions. These results demonstrate that complementing the proposed feature set with a baseline set is a promising approach.

Expression of the histone chaperone SET/TAF-Iβ during the strobilation process of Mesocestoides corti (Platyhelminthes, Cestoda).

PubMed

Costa, Caroline B; Monteiro, Karina M; Teichmann, Aline; da Silva, Edileuza D; Lorenzatto, Karina R; Cancela, Martín; Paes, Jéssica A; Benitz, André de N D; Castillo, Estela; Margis, Rogério; Zaha, Arnaldo; Ferreira, Henrique B

2015-08-01

The histone chaperone SET/TAF-Iβ is implicated in processes of chromatin remodelling and gene expression regulation. It has been associated with the control of developmental processes, but little is known about its function in helminth parasites. In Mesocestoides corti, a partial cDNA sequence related to SET/TAF-Iβ was isolated in a screening for genes differentially expressed in larvae (tetrathyridia) and adult worms. Here, the full-length coding sequence of the M. corti SET/TAF-Iβ gene was analysed and the encoded protein (McSET/TAF) was compared with orthologous sequences, showing that McSET/TAF can be regarded as a SET/TAF-Iβ family member, with a typical nucleosome-assembly protein (NAP) domain and an acidic tail. The expression patterns of the McSET/TAF gene and protein were investigated during the strobilation process by RT-qPCR, using a set of five reference genes, and by immunoblot and immunofluorescence, using monospecific polyclonal antibodies. A gradual increase in McSET/TAF transcripts and McSET/TAF protein was observed upon development induction by trypsin, demonstrating McSET/TAF differential expression during strobilation. These results provided the first evidence for the involvement of a protein from the NAP family of epigenetic effectors in the regulation of cestode development.

Using lean methodology to improve efficiency of electronic order set maintenance in the hospital.

PubMed

Idemoto, Lori; Williams, Barbara; Blackmore, Craig

2016-01-01

Order sets, a series of orders focused around a diagnosis, condition, or treatment, can reinforce best practice, help eliminate outdated practice, and provide clinical guidance. However, order sets require regular updates as evidence and care processes change. We undertook a quality improvement intervention applying lean methodology to create a systematic process for order set review and maintenance. Root cause analysis revealed challenges with unclear prioritization of requests, lack of coordination between teams, and lack of communication between producers and requestors of order sets. In March of 2014, we implemented a systematic, cyclical order set review process, with a set schedule, defined responsibilities for various stakeholders, formal meetings and communication between stakeholders, and transparency of the process. We first identified and deactivated 89 order sets which were infrequently used. Between March and August 2014, 142 order sets went through the new review process. Processing time for the build duration of order sets decreased from a mean of 79.6 to 43.2 days (p<.001, CI=22.1, 50.7). Applying Lean production principles to the order set review process resulted in significant improvement in processing time and increased quality of orders. As use of order sets and other forms of clinical decision support increase, regular evidence and process updates become more critical.

Adaptive Set-Based Methods for Association Testing

PubMed Central

Su, Yu-Chen; Gauderman, W. James; Kiros, Berhane; Lewinger, Juan Pablo

2017-01-01

With a typical sample size of a few thousand subjects, a single genomewide association study (GWAS) using traditional one-SNP-at-a-time methods can only detect genetic variants conferring a sizable effect on disease risk. Set-based methods, which analyze sets of SNPs jointly, can detect variants with smaller effects acting within a gene, a pathway, or other biologically relevant sets. While self-contained set-based methods (those that test sets of variants without regard to variants not in the set) are generally more powerful than competitive set-based approaches (those that rely on comparison of variants in the set of interest with variants not in the set), there is no consensus as to which self-contained methods are best. In particular, several self-contained set tests have been proposed to directly or indirectly ‘adapt’ to the a priori unknown proportion and distribution of effects of the truly associated SNPs in the set, which is a major determinant of their power. A popular adaptive set-based test is the adaptive rank truncated product (ARTP), which seeks the set of SNPs that yields the best-combined evidence of association. We compared the standard ARTP, several ARTP variations we introduced, and other adaptive methods in a comprehensive simulation study to evaluate their performance. We used permutations to assess significance for all the methods and thus provide a level playing field for comparison. We found the standard ARTP test to have the highest power across our simulations followed closely by the global model of random effects (GMRE) and a LASSO based test. PMID:26707371

Trial type mixing substantially reduces the response set effect in the Stroop task.

PubMed

Hasshim, Nabil; Parris, Benjamin A

2017-03-20

The response set effect refers to the finding that an irrelevant incongruent colour-word produces greater interference when it is one of the response options (referred to as a response set trial), compared to when it is not (a non-response set trial). Despite being a key effect for models of selective attention, the magnitude of the effect varies considerably across studies. We report two within-subjects experiments that tested the hypothesis that presentation format modulates the magnitude of the response set effect. Trial types (e.g. response set, non-response set, neutral) were either presented in separate blocks (pure) or in blocks containing trials from all conditions presented randomly (mixed). In the first experiment we show that the response set effect is substantially reduced in the mixed block context as a result of a decrease in RTs to response set trials. By demonstrating the modulation of the response set effect under conditions of trial type mixing we present evidence that is difficult for models of the effect based on strategic, top-down biasing of attention to explain. In a second experiment we tested a stimulus-driven account of the response set effect by manipulating the number of colour-words that make up the non-response set of distractors. The results show that the greater the number of non-response set colour concepts, the smaller the response set effect. Alternative accounts of the data and its implications for research debating the automaticity of reading are discussed. Copyright © 2017 Elsevier B.V. All rights reserved.

Similar hypotensive effects of combined aerobic and resistance exercise with 1 set versus 3 sets in women with metabolic syndrome.

PubMed

Tibana, Ramires A; Nascimento, Dahan da C; de Sousa, Nuno M F; de Almeida, Jeeser A; Moraes, Milton R; Durigan, João Luiz Quagliotti; Collier, Scott R; Prestes, Jonato

2015-11-01

The aim of the present study was to compare the response of systolic blood pressure (SBP), mean blood pressure (MBP) and diastolic blood pressure (DBP) following combined training with 1 set or with 3 sets of resistance exercise (RE). Sixteen women with metabolic syndrome (MetS) were randomly assigned to perform two combined exercise protocols and a control session (CON): 1-set, 30 min of aerobic exercise (AE) at 65-70% of reserve heart rate and 1 set of 8-12 repetitions at 80% of 10-RM in six resistance exercises; 3-sets, same protocol but with 3 sets; and CON, 30 min of seated rest. The SBP, MBP and DBP were measured before and every 15 min during 90 min following the experimental sessions. The SBP displayed a decrease (P ≤ 0.05) during the 90 min following the RE session with 1-set and 3-set, while MBP was decreased (P ≤ 0.05) up to 75 min after 1-set and up to 30 min after the 3-set exercise session compared with pre-intervention values. There was a decrease in DBP only for the greatest individual decrease following 1-set (-6.1 mmHg) and 3-set (-4.9 mmHg) combined exercise sessions, without differences between them. The rate-pressure product and heart rate remained significantly higher (P ≤ 0.05) 75 min and 90 min after the combined exercise session with 1- and 3-sets compared with the CON, respectively. In conclusion, a low-volume RE combined with AE resulted in similar decrease of SBP when compared with RE with 3-sets in women with MetS, which could be beneficial in situations of limited time. © 2014 Scandinavian Society of Clinical Physiology and Nuclear Medicine. Published by John Wiley & Sons Ltd.

Proteomic analysis of trichloroethylene-induced alterations in expression, distribution, and interactions of SET/TAF-Iα and two SET/TAF-Iα-binding proteins, eEF1A1 and eEF1A2, in hepatic L-02 cells.

PubMed

Hong, Wen-Xu; Yang, Liang; Chen, Moutong; Yang, Xifei; Ren, Xiaohu; Fang, Shisong; Ye, Jinbo; Huang, Haiyan; Peng, Chaoqiong; Zhou, Li; Huang, Xinfeng; Yang, Fan; Wu, Desheng; Zhuang, Zhixiong; Liu, Jianjun

2012-09-01

Emerging evidence indicates that trichloroethylene (TCE) exposure causes severe hepatotoxicity. However, the mechanisms of TCE hepatotoxicity remain unclear. Recently, we reported that TCE exposure up-regulated the expression of the oncoprotein SET/TAF-Iα and SET knockdown attenuated TCE-induced cytotoxicity in hepatic L-02 cells. To decipher the function of SET/TAF-Iα and its contributions to TCE-induced hepatotoxicity, we employed a proteomic analysis of SET/TAF-Iα with tandem affinity purification to identify SET/TAF-Iα-binding proteins. We identified 42 novel Gene Ontology co-annotated SET/TAF-Iα-binding proteins. The identifications of two of these proteins (eEF1A1, elongation factor 1-alpha 1; eEF1A2, elongation factor 1-alpha 2) were confirmed by Western blot analysis and co-immunoprecipitation (Co-IP). Furthermore, we analyzed the effects of TCE on the expression, distribution and interactions of eEF1A1, eEF1A2 and SET in L-02 cells. Western blot analysis reveals a significant up-regulation of eEF1A1, eEF1A2 and two isoforms of SET, and immunocytochemical analysis reveals that eEF1A1 and SET is redistributed by TCE. SET is redistributed from the nucleus to the cytoplasm, while eFE1A1 is translocated from the cytoplasm to the nucleus. Moreover, we find by Co-IP that TCE exposure significantly increases the interaction of SET with eEF1A2. Our data not only provide insights into the physiological functions of SET/TAF-Iα and complement the SET interaction networks, but also demonstrate that TCE exposure induces alterations in the expression, distribution and interactions of SET and its binding partners. These alterations may constitute the mechanisms of TCE cytotoxicity. Copyright © 2012 Elsevier Inc. All rights reserved.

Discrete Ordinate Quadrature Selection for Reactor-based Eigenvalue Problems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jarrell, Joshua J; Evans, Thomas M; Davidson, Gregory G

2013-01-01

In this paper we analyze the effect of various quadrature sets on the eigenvalues of several reactor-based problems, including a two-dimensional (2D) fuel pin, a 2D lattice of fuel pins, and a three-dimensional (3D) reactor core problem. While many quadrature sets have been applied to neutral particle discrete ordinate transport calculations, the Level Symmetric (LS) and the Gauss-Chebyshev product (GC) sets are the most widely used in production-level reactor simulations. Other quadrature sets, such as Quadruple Range (QR) sets, have been shown to be more accurate in shielding applications. In this paper, we compare the LS, GC, QR, and themore » recently developed linear-discontinuous finite element (LDFE) sets, as well as give a brief overview of other proposed quadrature sets. We show that, for a given number of angles, the QR sets are more accurate than the LS and GC in all types of reactor problems analyzed (2D and 3D). We also show that the LDFE sets are more accurate than the LS and GC sets for these problems. We conclude that, for problems where tens to hundreds of quadrature points (directions) per octant are appropriate, QR sets should regularly be used because they have similar integration properties as the LS and GC sets, have no noticeable impact on the speed of convergence of the solution when compared with other quadrature sets, and yield more accurate results. We note that, for very high-order scattering problems, the QR sets exactly integrate fewer angular flux moments over the unit sphere than the GC sets. The effects of those inexact integrations have yet to be analyzed. We also note that the LDFE sets only exactly integrate the zeroth and first angular flux moments. Pin power comparisons and analyses are not included in this paper and are left for future work.« less

Discrete ordinate quadrature selection for reactor-based Eigenvalue problems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jarrell, J. J.; Evans, T. M.; Davidson, G. G.

2013-07-01

In this paper we analyze the effect of various quadrature sets on the eigenvalues of several reactor-based problems, including a two-dimensional (2D) fuel pin, a 2D lattice of fuel pins, and a three-dimensional (3D) reactor core problem. While many quadrature sets have been applied to neutral particle discrete ordinate transport calculations, the Level Symmetric (LS) and the Gauss-Chebyshev product (GC) sets are the most widely used in production-level reactor simulations. Other quadrature sets, such as Quadruple Range (QR) sets, have been shown to be more accurate in shielding applications. In this paper, we compare the LS, GC, QR, and themore » recently developed linear-discontinuous finite element (LDFE) sets, as well as give a brief overview of other proposed quadrature sets. We show that, for a given number of angles, the QR sets are more accurate than the LS and GC in all types of reactor problems analyzed (2D and 3D). We also show that the LDFE sets are more accurate than the LS and GC sets for these problems. We conclude that, for problems where tens to hundreds of quadrature points (directions) per octant are appropriate, QR sets should regularly be used because they have similar integration properties as the LS and GC sets, have no noticeable impact on the speed of convergence of the solution when compared with other quadrature sets, and yield more accurate results. We note that, for very high-order scattering problems, the QR sets exactly integrate fewer angular flux moments over the unit sphere than the GC sets. The effects of those inexact integrations have yet to be analyzed. We also note that the LDFE sets only exactly integrate the zeroth and first angular flux moments. Pin power comparisons and analyses are not included in this paper and are left for future work. (authors)« less

45 CFR 162.1011 - Valid code sets.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 1 2012-10-01 2012-10-01 false Valid code sets. 162.1011 Section 162.1011 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES ADMINISTRATIVE DATA STANDARDS AND RELATED REQUIREMENTS ADMINISTRATIVE REQUIREMENTS Code Sets § 162.1011 Valid code sets. Each code set is valid within the dates...

45 CFR 162.1011 - Valid code sets.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 1 2013-10-01 2013-10-01 false Valid code sets. 162.1011 Section 162.1011 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES ADMINISTRATIVE DATA STANDARDS AND RELATED REQUIREMENTS ADMINISTRATIVE REQUIREMENTS Code Sets § 162.1011 Valid code sets. Each code set is valid within the dates...

45 CFR 162.1011 - Valid code sets.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Valid code sets. 162.1011 Section 162.1011 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES ADMINISTRATIVE DATA STANDARDS AND RELATED REQUIREMENTS ADMINISTRATIVE REQUIREMENTS Code Sets § 162.1011 Valid code sets. Each code set is valid within the dates...

45 CFR 162.1011 - Valid code sets.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 1 2014-10-01 2014-10-01 false Valid code sets. 162.1011 Section 162.1011 Public Welfare Department of Health and Human Services ADMINISTRATIVE DATA STANDARDS AND RELATED REQUIREMENTS ADMINISTRATIVE REQUIREMENTS Code Sets § 162.1011 Valid code sets. Each code set is valid within the dates...

45 CFR 162.1011 - Valid code sets.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 1 2011-10-01 2011-10-01 false Valid code sets. 162.1011 Section 162.1011 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES ADMINISTRATIVE DATA STANDARDS AND RELATED REQUIREMENTS ADMINISTRATIVE REQUIREMENTS Code Sets § 162.1011 Valid code sets. Each code set is valid within the dates...

Improving a Lecture-Size Molecular Model Set by Repurposing Used Whiteboard Markers

ERIC Educational Resources Information Center

Dragojlovic, Veljko

2015-01-01

Preparation of an inexpensive model set from whiteboard markers and either HGS molecular model set or atoms made of wood is described. The model set is relatively easy to prepare and is sufficiently large to be suitable as an instructor set for use in lectures.

The Effects of Teacher-Set and Student-Set Accelerated Reader Goal Setting on Reading Comprehension and Student Attitudes towards Reading in Fourth- and Fifth-Grade Students

ERIC Educational Resources Information Center

Tucker, Tiffany G.

2016-01-01

The purpose of this research study was to compare the impact of Teacher-Set Accelerated Reader goals (TSAR) with Student-Set Accelerated Reader goals (SSAR) of fourth- and fifth-grade students. The goal of this research study was to determine which type of goal setting approach influences reading growth the most as measured by the easyCBM…

Task Identification and Evaluation System (TIES)

DTIC Science & Technology

1991-08-01

Caliorate A N/AVh-11A- iUD -test -sets 127. Calibrate AN/AWII1-55 ASCU test setsI - 128. Calibrate 5001L11 tally punched tape readersI- 129. Perform...11AKHbD test sets -- 132. ?erform fault isolation of U4/AWN-55 ASCU -test sets -- 133. Perform fault isolation of 500 R.M tally punched tape I...AIN/AVM1-11A HfLM test sets- 137. Perf-orm self-tests of AL%/AWL-S5 ASCU test sets G. !MAI.T.T!ING A-7D_ ANUAL TEST SETS 138. Adjust SM-661/AS-388air

Method Of Wire Insertion For Electric Machine Stators

DOEpatents

Brown, David L; Stabel, Gerald R; Lawrence, Robert Anthony

2005-02-08

A method of inserting coils in slots of a stator is provided. The method includes interleaving a first set of first phase windings and a first set of second phase windings on an insertion tool. The method also includes activating the insertion tool to radially insert the first set of first phase windings and the first set of second phase windings in the slots of the stator. In one embodiment, interleaving the first set of first phase windings and the first set of second phase windings on the insertion tool includes forming the first set of first phase windings in first phase openings defined in the insertion tool, and forming the first set of second phase windings in second phase openings defined in the insertion tool.

UpSetR: an R package for the visualization of intersecting sets and their properties

PubMed Central

Conway, Jake R.; Lex, Alexander; Gehlenborg, Nils

2017-01-01

Abstract Motivation: Venn and Euler diagrams are a popular yet inadequate solution for quantitative visualization of set intersections. A scalable alternative to Venn and Euler diagrams for visualizing intersecting sets and their properties is needed. Results: We developed UpSetR, an open source R package that employs a scalable matrix-based visualization to show intersections of sets, their size, and other properties. Availability and implementation: UpSetR is available at https://github.com/hms-dbmi/UpSetR/ and released under the MIT License. A Shiny app is available at https://gehlenborglab.shinyapps.io/upsetr/. Contact: nils@hms.harvard.edu Supplementary information: Supplementary data are available at Bioinformatics online. PMID:28645171

Physiological studies of fruit set in strawberry (Fragaria x ananassa Duch. )

DOE Office of Scientific and Technical Information (OSTI.GOV)

Darnell, R.L.

1986-01-01

The present study was initiated to test the hypothesis that hormones control fruit set by controlling the amount of assimilate transport and accumulation in fruit tissues. The objectives were to compare assimilate mobilization and accumulation in two treatments which induced fruit set; i.e. pollination and exogenous hormone application, versus a non-pollinated treatment which did not induce fruit set. Initial experiments revealed that several auxins which induce parthenocarpic set in June-bearing strawberries did not induce set in the day-neutral cultivar used in this study. The only auxin found which induced set with a single application was indoleacetic acid ethyl ester (Et-IAA).more » Subsequently, /sup 14/C-Et-IAA was synthesized and the translocation and metabolism of this auxin was examined and correlated with fruit set and initial growth. Et-IAA transport out of the receptacle was not required for induction of set and growth.« less

Some New Sets of Sequences of Fuzzy Numbers with Respect to the Partial Metric

PubMed Central

Ozluk, Muharrem

2015-01-01

In this paper, we essentially deal with Köthe-Toeplitz duals of fuzzy level sets defined using a partial metric. Since the utilization of Zadeh's extension principle is quite difficult in practice, we prefer the idea of level sets in order to construct some classical notions. In this paper, we present the sets of bounded, convergent, and null series and the set of sequences of bounded variation of fuzzy level sets, based on the partial metric. We examine the relationships between these sets and their classical forms and give some properties including definitions, propositions, and various kinds of partial metric spaces of fuzzy level sets. Furthermore, we study some of their properties like completeness and duality. Finally, we obtain the Köthe-Toeplitz duals of fuzzy level sets with respect to the partial metric based on a partial ordering. PMID:25695102

Pseudo-set framing.

PubMed

Barasz, Kate; John, Leslie K; Keenan, Elizabeth A; Norton, Michael I

2017-10-01

Pseudo-set framing-arbitrarily grouping items or tasks together as part of an apparent "set"-motivates people to reach perceived completion points. Pseudo-set framing changes gambling choices (Study 1), effort (Studies 2 and 3), giving behavior (Field Data and Study 4), and purchase decisions (Study 5). These effects persist in the absence of any reward, when a cost must be incurred, and after participants are explicitly informed of the arbitrariness of the set. Drawing on Gestalt psychology, we develop a conceptual account that predicts what will-and will not-act as a pseudo-set, and defines the psychological process through which these pseudo-sets affect behavior: over and above typical reference points, pseudo-set framing alters perceptions of (in)completeness, making intermediate progress seem less complete. In turn, these feelings of incompleteness motivate people to persist until the pseudo-set has been fulfilled. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Complex fuzzy soft expert sets

NASA Astrophysics Data System (ADS)

Selvachandran, Ganeshsree; Hafeed, Nisren A.; Salleh, Abdul Razak

2017-04-01

Complex fuzzy sets and its accompanying theory although at its infancy, has proven to be superior to classical type-1 fuzzy sets, due its ability in representing time-periodic problem parameters and capturing the seasonality of the fuzziness that exists in the elements of a set. These are important characteristics that are pervasive in most real world problems. However, there are two major problems that are inherent in complex fuzzy sets: it lacks a sufficient parameterization tool and it does not have a mechanism to validate the values assigned to the membership functions of the elements in a set. To overcome these problems, we propose the notion of complex fuzzy soft expert sets which is a hybrid model of complex fuzzy sets and soft expert sets. This model incorporates the advantages of complex fuzzy sets and soft sets, besides having the added advantage of allowing the users to know the opinion of all the experts in a single model without the need for any additional cumbersome operations. As such, this model effectively improves the accuracy of representation of problem parameters that are periodic in nature, besides having a higher level of computational efficiency compared to similar models in literature.

UpSet: Visualization of Intersecting Sets

PubMed Central

Lex, Alexander; Gehlenborg, Nils; Strobelt, Hendrik; Vuillemot, Romain; Pfister, Hanspeter

2016-01-01

Understanding relationships between sets is an important analysis task that has received widespread attention in the visualization community. The major challenge in this context is the combinatorial explosion of the number of set intersections if the number of sets exceeds a trivial threshold. In this paper we introduce UpSet, a novel visualization technique for the quantitative analysis of sets, their intersections, and aggregates of intersections. UpSet is focused on creating task-driven aggregates, communicating the size and properties of aggregates and intersections, and a duality between the visualization of the elements in a dataset and their set membership. UpSet visualizes set intersections in a matrix layout and introduces aggregates based on groupings and queries. The matrix layout enables the effective representation of associated data, such as the number of elements in the aggregates and intersections, as well as additional summary statistics derived from subset or element attributes. Sorting according to various measures enables a task-driven analysis of relevant intersections and aggregates. The elements represented in the sets and their associated attributes are visualized in a separate view. Queries based on containment in specific intersections, aggregates or driven by attribute filters are propagated between both views. We also introduce several advanced visual encodings and interaction methods to overcome the problems of varying scales and to address scalability. UpSet is web-based and open source. We demonstrate its general utility in multiple use cases from various domains. PMID:26356912

Assessing the validity of commercial and municipal food environment data sets in Vancouver, Canada.

PubMed

Daepp, Madeleine Ig; Black, Jennifer

2017-10-01

The present study assessed systematic bias and the effects of data set error on the validity of food environment measures in two municipal and two commercial secondary data sets. Sensitivity, positive predictive value (PPV) and concordance were calculated by comparing two municipal and two commercial secondary data sets with ground-truthed data collected within 800 m buffers surrounding twenty-six schools. Logistic regression examined associations of sensitivity and PPV with commercial density and neighbourhood socio-economic deprivation. Kendall's τ estimated correlations between density and proximity of food outlets near schools constructed with secondary data sets v. ground-truthed data. Vancouver, Canada. Food retailers located within 800 m of twenty-six schools RESULTS: All data sets scored relatively poorly across validity measures, although, overall, municipal data sets had higher levels of validity than did commercial data sets. Food outlets were more likely to be missing from municipal health inspections lists and commercial data sets in neighbourhoods with higher commercial density. Still, both proximity and density measures constructed from all secondary data sets were highly correlated (Kendall's τ>0·70) with measures constructed from ground-truthed data. Despite relatively low levels of validity in all secondary data sets examined, food environment measures constructed from secondary data sets remained highly correlated with ground-truthed data. Findings suggest that secondary data sets can be used to measure the food environment, although estimates should be treated with caution in areas with high commercial density.

SET protein accumulates in HNSCC and contributes to cell survival: antioxidant defense, Akt phosphorylation and AVOs acidification.

PubMed

Leopoldino, Andréia M; Squarize, Cristiane H; Garcia, Cristiana B; Almeida, Luciana O; Pestana, Cezar R; Sobral, Lays M; Uyemura, Sérgio A; Tajara, Eloiza H; Silvio Gutkind, J; Curti, Carlos

2012-11-01

Determination of the SET protein levels in head and neck squamous cell carcinoma (HNSCC) tissue samples and the SET role in cell survival and response to oxidative stress in HNSCC cell lineages. SET protein was analyzed in 372 HNSCC tissue samples by immunohistochemistry using tissue microarray and HNSCC cell lineages. Oxidative stress was induced with the pro-oxidant tert-butylhydroperoxide (50 and 250μM) in the HNSCC HN13 cell lineage either with (siSET) or without (siNC) SET knockdown. Cell viability was evaluated by trypan blue exclusion and annexin V/propidium iodide assays. It was assessed caspase-3 and -9, PARP-1, DNA fragmentation, NM23-H1, SET, Akt and phosphorylated Akt (p-Akt) status. Acidic vesicular organelles (AVOs) were assessed by the acridine orange assay. Glutathione levels and transcripts of antioxidant genes were assayed by fluorometry and real time PCR, respectively. SET levels were up-regulated in 97% tumor tissue samples and in HNSCC cell lineages. SiSET in HN13 cells (i) promoted cell death but did not induced caspases, PARP-1 cleavage or DNA fragmentation, and (ii) decreased resistance to death induced by oxidative stress, indicating SET involvement through caspase-independent mechanism. The red fluorescence induced by siSET in HN13 cells in the acridine orange assay suggests SET-dependent prevention of AVOs acidification. NM23-H1 protein was restricted to the cytoplasm of siSET/siNC HN13 cells under oxidative stress, in association with decrease of cleaved SET levels. In the presence of oxidative stress, siNC HN13 cells showed lower GSH antioxidant defense (GSH/GSSG ratio) but higher expression of the antioxidant genes PRDX6, SOD2 and TXN compared to siSET HN13 cells. Still under oxidative stress, p-Akt levels were increased in siNC HN13 cells but not in siSET HN13, indicating its involvement in HN13 cell survival. Similar results for the main SET effects were observed in HN12 and CAL 27 cell lineages, except that HN13 cells were more resistant to death. SET is potential (i) marker for HNSCC associated with cancer cell resistance and (ii) new target in cancer therapy. Copyright © 2012 Elsevier Ltd. All rights reserved.

Adaptive Set-Based Methods for Association Testing.

PubMed

Su, Yu-Chen; Gauderman, William James; Berhane, Kiros; Lewinger, Juan Pablo

2016-02-01

With a typical sample size of a few thousand subjects, a single genome-wide association study (GWAS) using traditional one single nucleotide polymorphism (SNP)-at-a-time methods can only detect genetic variants conferring a sizable effect on disease risk. Set-based methods, which analyze sets of SNPs jointly, can detect variants with smaller effects acting within a gene, a pathway, or other biologically relevant sets. Although self-contained set-based methods (those that test sets of variants without regard to variants not in the set) are generally more powerful than competitive set-based approaches (those that rely on comparison of variants in the set of interest with variants not in the set), there is no consensus as to which self-contained methods are best. In particular, several self-contained set tests have been proposed to directly or indirectly "adapt" to the a priori unknown proportion and distribution of effects of the truly associated SNPs in the set, which is a major determinant of their power. A popular adaptive set-based test is the adaptive rank truncated product (ARTP), which seeks the set of SNPs that yields the best-combined evidence of association. We compared the standard ARTP, several ARTP variations we introduced, and other adaptive methods in a comprehensive simulation study to evaluate their performance. We used permutations to assess significance for all the methods and thus provide a level playing field for comparison. We found the standard ARTP test to have the highest power across our simulations followed closely by the global model of random effects (GMRE) and a least absolute shrinkage and selection operator (LASSO)-based test. © 2015 WILEY PERIODICALS, INC.

Spectral gene set enrichment (SGSE).

PubMed

Frost, H Robert; Li, Zhigang; Moore, Jason H

2015-03-03

Gene set testing is typically performed in a supervised context to quantify the association between groups of genes and a clinical phenotype. In many cases, however, a gene set-based interpretation of genomic data is desired in the absence of a phenotype variable. Although methods exist for unsupervised gene set testing, they predominantly compute enrichment relative to clusters of the genomic variables with performance strongly dependent on the clustering algorithm and number of clusters. We propose a novel method, spectral gene set enrichment (SGSE), for unsupervised competitive testing of the association between gene sets and empirical data sources. SGSE first computes the statistical association between gene sets and principal components (PCs) using our principal component gene set enrichment (PCGSE) method. The overall statistical association between each gene set and the spectral structure of the data is then computed by combining the PC-level p-values using the weighted Z-method with weights set to the PC variance scaled by Tracy-Widom test p-values. Using simulated data, we show that the SGSE algorithm can accurately recover spectral features from noisy data. To illustrate the utility of our method on real data, we demonstrate the superior performance of the SGSE method relative to standard cluster-based techniques for testing the association between MSigDB gene sets and the variance structure of microarray gene expression data. Unsupervised gene set testing can provide important information about the biological signal held in high-dimensional genomic data sets. Because it uses the association between gene sets and samples PCs to generate a measure of unsupervised enrichment, the SGSE method is independent of cluster or network creation algorithms and, most importantly, is able to utilize the statistical significance of PC eigenvalues to ignore elements of the data most likely to represent noise.

U.S. Food Safety and Inspection Service testing for Salmonella in selected raw meat and poultry products in the United States, 1998 through 2003: analysis of set results.

PubMed

Naugle, Alecia Larew; Barlow, Kristina E; Eblen, Denise R; Teter, Vanessa; Umholtz, Robert

2006-11-01

The U.S. Food Safety and Inspection Service (FSIS) tests sets of samples of selected raw meat and poultry products for Salmonella to ensure that federally inspected establishments meet performance standards defined in the pathogen reduction-hazard analysis and critical control point system (PR-HACCP) final rule. In the present report, sample set results are described and associations between set failure and set and establishment characteristics are identified for 4,607 sample sets collected from 1998 through 2003. Sample sets were obtained from seven product classes: broiler chicken carcasses (n = 1,010), cow and bull carcasses (n = 240), market hog carcasses (n = 560), steer and heifer carcasses (n = 123), ground beef (n = 2,527), ground chicken (n = 31), and ground turkey (n = 116). Of these 4,607 sample sets, 92% (4,255) were collected as part of random testing efforts (A sets), and 93% (4,166) passed. However, the percentage of positive samples relative to the maximum number of positive results allowable in a set increased over time for broilers but decreased or stayed the same for the other product classes. Three factors associated with set failure were identified: establishment size, product class, and year. Set failures were more likely early in the testing program (relative to 2003). Small and very small establishments were more likely to fail than large ones. Set failure was less likely in ground beef than in other product classes. Despite an overall decline in set failures through 2003, these results highlight the need for continued vigilance to reduce Salmonella contamination in broiler chicken and continued implementation of programs designed to assist small and very small establishments with PR-HACCP compliance issues.

Maximizing the probability of satisfying the clinical goals in radiation therapy treatment planning under setup uncertainty

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fredriksson, Albin, E-mail: albin.fredriksson@raysearchlabs.com; Hårdemark, Björn; Forsgren, Anders

2015-07-15

Purpose: This paper introduces a method that maximizes the probability of satisfying the clinical goals in intensity-modulated radiation therapy treatments subject to setup uncertainty. Methods: The authors perform robust optimization in which the clinical goals are constrained to be satisfied whenever the setup error falls within an uncertainty set. The shape of the uncertainty set is included as a variable in the optimization. The goal of the optimization is to modify the shape of the uncertainty set in order to maximize the probability that the setup error will fall within the modified set. Because the constraints enforce the clinical goalsmore » to be satisfied under all setup errors within the uncertainty set, this is equivalent to maximizing the probability of satisfying the clinical goals. This type of robust optimization is studied with respect to photon and proton therapy applied to a prostate case and compared to robust optimization using an a priori defined uncertainty set. Results: Slight reductions of the uncertainty sets resulted in plans that satisfied a larger number of clinical goals than optimization with respect to a priori defined uncertainty sets, both within the reduced uncertainty sets and within the a priori, nonreduced, uncertainty sets. For the prostate case, the plans taking reduced uncertainty sets into account satisfied 1.4 (photons) and 1.5 (protons) times as many clinical goals over the scenarios as the method taking a priori uncertainty sets into account. Conclusions: Reducing the uncertainty sets enabled the optimization to find better solutions with respect to the errors within the reduced as well as the nonreduced uncertainty sets and thereby achieve higher probability of satisfying the clinical goals. This shows that asking for a little less in the optimization sometimes leads to better overall plan quality.« less

GSA-PCA: gene set generation by principal component analysis of the Laplacian matrix of a metabolic network

PubMed Central

2012-01-01

Background Gene Set Analysis (GSA) has proven to be a useful approach to microarray analysis. However, most of the method development for GSA has focused on the statistical tests to be used rather than on the generation of sets that will be tested. Existing methods of set generation are often overly simplistic. The creation of sets from individual pathways (in isolation) is a poor reflection of the complexity of the underlying metabolic network. We have developed a novel approach to set generation via the use of Principal Component Analysis of the Laplacian matrix of a metabolic network. We have analysed a relatively simple data set to show the difference in results between our method and the current state-of-the-art pathway-based sets. Results The sets generated with this method are semi-exhaustive and capture much of the topological complexity of the metabolic network. The semi-exhaustive nature of this method has also allowed us to design a hypergeometric enrichment test to determine which genes are likely responsible for set significance. We show that our method finds significant aspects of biology that would be missed (i.e. false negatives) and addresses the false positive rates found with the use of simple pathway-based sets. Conclusions The set generation step for GSA is often neglected but is a crucial part of the analysis as it defines the full context for the analysis. As such, set generation methods should be robust and yield as complete a representation of the extant biological knowledge as possible. The method reported here achieves this goal and is demonstrably superior to previous set analysis methods. PMID:22876834

Randomized Trial of Infusion Set Function: Steel Versus Teflon

PubMed Central

Patel, Parul J.; Benasi, Kari; Ferrari, Gina; Evans, Mark G.; Shanmugham, Satya; Wilson, Darrell M.

2014-01-01

Abstract Background: This study compared infusion set function for up to 1 week using either a Teflon® (Dupont™, Wilmington, DE) catheter or a steel catheter for insulin pump therapy in type 1 diabetes mellitus. Subjects and Methods: Twenty subjects participating in a randomized, open-labeled, crossover study were asked to wear two Quick-Set® and two Sure-T® infusion sets (both from Medtronic Minimed, Northridge, CA) until the infusion set failed or was worn for 1 week. All subjects wore a MiniMed continuous glucose monitoring system for the duration of the study. Results: One subject withdrew from the study. There were 38 weeks of Sure-T wear and 39 weeks of Quick-Set wear with no difference in the survival curves of the infusion sets. There was, however, a 15% initial failure rate with the Teflon infusion set. After 7 days, both types of infusion sets had a 64% failure rate. Overall, 30% failed because of hyperglycemia and a failed correction dose, 13% were removed for pain, 10% were pulled out by accident, 10% had erythema and/or induration of>10 mm, 5% fell out because of loss of adhesion, and 4% were removed for infection. The main predictor of length of wear was the individual subject. There was no increase in hyperglycemia or daily insulin requirements when an infusion set was successfully used for 7 days (n=25 of 77 weeks). Conclusions: We found no difference between steel and Teflon infusion sets in their function over 7 days, although 15% of Teflon sets failed because of kinking on insertion. The strongest predictor of prolonged 7-day infusion set function was the individual subject, not the type of infusion set. PMID:24090124

Quantum Sets and Clifford Algebras

NASA Astrophysics Data System (ADS)

Finkelstein, David

1982-06-01

The mathematical language presently used for quantum physics is a high-level language. As a lowest-level or basic language I construct a quantum set theory in three stages: (1) Classical set theory, formulated as a Clifford algebra of “ S numbers” generated by a single monadic operation, “bracing,” Br = {…}. (2) Indefinite set theory, a modification of set theory dealing with the modal logical concept of possibility. (3) Quantum set theory. The quantum set is constructed from the null set by the familiar quantum techniques of tensor product and antisymmetrization. There are both a Clifford and a Grassmann algebra with sets as basis elements. Rank and cardinality operators are analogous to Schroedinger coordinates of the theory, in that they are multiplication or “ Q-type” operators. “ P-type” operators analogous to Schroedinger momenta, in that they transform the Q-type quantities, are bracing (Br), Clifford multiplication by a set X, and the creator of X, represented by Grassmann multiplication c( X) by the set X. Br and its adjoint Br* form a Bose-Einstein canonical pair, and c( X) and its adjoint c( X)* form a Fermi-Dirac or anticanonical pair. Many coefficient number systems can be employed in this quantization. I use the integers for a discrete quantum theory, with the usual complex quantum theory as limit. Quantum set theory may be applied to a quantum time space and a quantum automaton.