The Liouville Theorem and the L 2 Decay for the FENE Dumbbell Model of Polymeric Flows
NASA Astrophysics Data System (ADS)
Luo, Wei; Yin, Zhaoyang
2016-12-01
In this paper we mainly study the finite extensible nonlinear elastic (FENE) dumbbell model with dimension {d ≥q 2} in the whole space. We first prove that there is only the trivial solution for the steady-state FENE model under some integrable condition. The obtained results generalize and cover the classical results for the stationary Navier-Stokes equations. We then obtain that the L 2 decay rate of the velocity of the co-rotation FENE model is {(1+t)^{-d/4}} when {d ≥q 3} , and {ln^{-k}{(e+t)}, kin N+} when d = 2. This result improves considerably the recent result of Schonbek (SIAM J Math Anal 41:564-587, 2009). Moreover, we investigate the L 2 decay of solutions to the general FENE model.
The Liouville Theorem and the L 2 Decay for the FENE Dumbbell Model of Polymeric Flows
NASA Astrophysics Data System (ADS)
Luo, Wei; Yin, Zhaoyang
2017-04-01
In this paper we mainly study the finite extensible nonlinear elastic (FENE) dumbbell model with dimension {d ≥q 2} in the whole space. We first prove that there is only the trivial solution for the steady-state FENE model under some integrable condition. The obtained results generalize and cover the classical results for the stationary Navier-Stokes equations. We then obtain that the L 2 decay rate of the velocity of the co-rotation FENE model is {(1+t)^{-d/4}} when {d ≥q 3}, and {ln^{-k}{(e+t)}, kin N+} when d = 2. This result improves considerably the recent result of Schonbek (SIAM J Math Anal 41:564-587, 2009). Moreover, we investigate the L 2 decay of solutions to the general FENE model.
A numerical study of the FENE-CR model applied to a jet flow problem
NASA Astrophysics Data System (ADS)
Paulo, G. S.; Oishi, C. M.; Tomé, M. F.
2013-10-01
The FENE-CR model is investigated through a numerical algorithm to simulate the time-dependent moving free surface flow produced by a jet impinging on a flat surface. The objective is to demonstrate that by increasing the extensibility parameter L, the numerical solutions converge to the solutions obtained with the Oldroyd-B model. The governing equations are solved by an established free surface flow solver based on the finite difference and marker-and-cell methods. Numerical predictions of the extensional viscosity obtained with several values of the parameter L are presented. The results show that if the extensibility parameter L is sufficiently large then the extensional viscosities obtained with the FENE-CR model approximate the corresponding Oldroyd-B viscosity. Moreover, the flow from a jet impinging on a flat surface is simulated with various values of the extensibility parameter L and the fluid flow visualizations display convergence to the Oldroyd-B jet flow results.
Griebel, M. E-mail: ruettgers@ins.uni-bonn.de; Rüttgers, A. E-mail: ruettgers@ins.uni-bonn.de
2014-05-15
The multiscale FENE model is applied to a 3D square-square contraction flow problem. For this purpose, the stochastic Brownian configuration field method (BCF) has been coupled with our fully parallelized three-dimensional Navier-Stokes solver NaSt3DGPF. The robustness of the BCF method enables the numerical simulation of high Deborah number flows for which most macroscopic methods suffer from stability issues. The results of our simulations are compared with that of experimental measurements from literature and show a very good agreement. In particular, flow phenomena such as a strong vortex enhancement, streamline divergence and a flow inversion for highly elastic flows are reproduced. Due to their computational complexity, our simulations require massively parallel computations. Using a domain decomposition approach with MPI, the implementation achieves excellent scale-up results for up to 128 processors.
Dumbbell dipole model and its application in UXO discrimination
NASA Astrophysics Data System (ADS)
Sun, K.; O'Neill, K.; Barrowes, B. E.; Fernández, J. P.; Shubitidze, F.; Shamatava, I.; Paulsen, K. D.
2006-05-01
Electromagnetic Induction (EMI) is one of the most promising techniques for UXO discrimination. Target discrimination is usually formulated as an inverse problem typically requiring fast forward models for efficiency. The most successful and widely applied EMI forward model is the simple dipole model, which works well for simple objects when the observation points are not close to the target. For complicated cases, a single dipole is not sufficient and a number of dipoles (displaced dipoles) has been suggested. However, once more than one dipole is needed, it is difficult to infer a unique set of model parameters from measurement data, which is usually limited. Inspired by the displaced dipole model, we developed the dumbbell dipole model, which consists of a special combination of dipoles. We placed a center dipole and two anti-symmetric side dipoles on the target axis. The center dipole functions like the traditional single dipole model and the two side dipoles provide the non-symmetric response of the target. When the distance between dipoles is small, this model is essentially a dipole plus a quadrupole. The advantage of the dumbbell model is that the model parameters can be inferred more easily from measurement data. The center dipole represents the main response of the target, the side dipoles act as additional backup in case a simple dipole is not sufficient. Regularization terms are applied so that the dumbbell dipole model automatically reduces to the simple dipole model in degenerate cases. Preliminary test shows that the dumbbell model can fit the measurement data better than the simple dipole model, and the inferred model parameters are unique for a given UXO. This suggests that the model parameters can be used as a discriminator for UXO. In this paper the dumbbell dipole model is introduced and its performance is compared with that of both the simple dipole model and the displaced dipole model.
NASA Astrophysics Data System (ADS)
Alexander, G. P.; Yeomans, J. M.
2008-08-01
We investigate the way in which oscillating dumb-bells, a simple microscopic model of apolar swimmers, move at low Reynold's number. In accordance with Purcell's Scallop Theorem a single dumb-bell cannot swim because its stroke is reciprocal in time. However the motion of two or more dumb-bells, with mutual phase differences, is not time reversal invariant, and hence swimming is possible. We use analytical and numerical solutions of the Stokes equations to calculate the hydrodynamic interaction between two dumb-bell swimmers and to discuss their relative motion. The cooperative effect of interactions between swimmers is explored by considering first regular, and then random arrays of dumb-bells. We find that a square array acts as a micropump. The long-time behaviour of suspensions of dumb-bells is investigated and compared to that of model polar swimmers.
NASA Astrophysics Data System (ADS)
Ferreira, Pedro O.; Pinho, Fernando T.; da Silva, Carlos B.
2016-12-01
A new subgrid-scale (SGS) model developed for large-eddy simulations (LES) of dilute polymer solutions, described by the finitely extensible nonlinear elastic constitutive equation closed with the Peterlin approximation, is presented. In this distortion similarity model (DSIM) the filtered conformation tensor evolution equation is based on the self-similarity of the polymer stretching terms, and on a global equilibrium of the trace of the conformation tensor, which is proportional to the elastic energy stored in the polymer molecules, while the SGS stresses are modelled with the classical Smagorinsky model. The DSIM closure is assessed in direct numerical simulations (DNS) of forced isotropic turbulence using classical a priori tests, and in a posteriori (LES) showing very good agreement with all the exact (filtered DNS) results. The DSIM model is simple to implement and computationally inexpensive and represents a major step forward in the numerical simulation of turbulent flows of Newtonian fluids with polymer additives.
NASA Astrophysics Data System (ADS)
Fischer, Lukas P.; Peter, Toni; Holm, Christian; de Graaf, Joost
2015-08-01
The so-called "raspberry" model refers to the hybrid lattice-Boltzmann and Langevin molecular dynamics scheme for simulating the dynamics of suspensions of colloidal particles, originally developed by Lobaskin and Dünweg [New J. Phys. 6, 54 (2004)], wherein discrete surface points are used to achieve fluid-particle coupling. This technique has been used in many simulation studies on the behavior of colloids. However, there are fundamental questions with regards to the use of this model. In this paper, we examine the accuracy with which the raspberry method is able to reproduce Stokes-level hydrodynamic interactions when compared to analytic expressions for solid spheres in simple-cubic crystals. To this end, we consider the quality of numerical experiments that are traditionally used to establish these properties and we discuss their shortcomings. We show that there is a discrepancy between the translational and rotational mobility reproduced by the simple raspberry model and present a way to numerically remedy this problem by adding internal coupling points. Finally, we examine a non-convex shape, namely, a colloidal dumbbell, and show that the filled raspberry model replicates the desired hydrodynamic behavior in bulk for this more complicated shape. Our investigation is continued in de Graaf et al. [J. Chem. Phys. 143, 084108 (2015)], wherein we consider the raspberry model in the confining geometry of two parallel plates.
Munaò, Gianmarco Costa, Dino; Caccamo, Carlo; Gámez, Francisco; Giacometti, Achille
2015-06-14
We investigate thermodynamic properties of anisotropic colloidal dumbbells in the frameworks provided by the Reference Interaction Site Model (RISM) theory and an Optimized Perturbation Theory (OPT), this latter based on a fourth-order high-temperature perturbative expansion of the free energy, recently generalized to molecular fluids. Our model is constituted by two identical tangent hard spheres surrounded by square-well attractions with same widths and progressively different depths. Gas-liquid coexistence curves are obtained by predicting pressures, free energies, and chemical potentials. In comparison with previous simulation results, RISM and OPT agree in reproducing the progressive reduction of the gas-liquid phase separation as the anisotropy of the interaction potential becomes more pronounced; in particular, the RISM theory provides reasonable predictions for all coexistence curves, bar the strong anisotropy regime, whereas OPT performs generally less well. Both theories predict a linear dependence of the critical temperature on the interaction strength, reproducing in this way the mean-field behavior observed in simulations; the critical density—that drastically drops as the anisotropy increases—turns to be less accurate. Our results appear as a robust benchmark for further theoretical studies, in support to the simulation approach, of self-assembly in model colloidal systems.
Large-eddy simulations of viscoelastic isotropic turbulence with the FENE-P fluid
NASA Astrophysics Data System (ADS)
Pinho, Fernando T.; Ferreira, Pedro O.; B. da Silva, Carlos; Idmec/Feup Collaboration
2016-11-01
A new subgrid-scale (SGS) model developed for large-eddy simulations (LES) of dilute polymer solutions described by the Finitely Extensible Nonlinear Elastic constitutive equation closed with the Peterlin approximation (FENE-P), is presented. The filtered conformation tensor evolution equation uses the self-similarity of the polymer stretching terms, and the global equilibrium of the trace of the conformation tensor, while the SGS stresses are modelled with the classical Smagorinsky model. The new closure is assessed in direct numerical simulations (DNS) of forced isotropic turbulence using classical a-priori tests, and in a-posteriori (LES) showing excellent agreement with all the exact (filtered DNS) results.
Magnetophoresis of flexible DNA-based dumbbell structures
NASA Astrophysics Data System (ADS)
Babić, B.; Ghai, R.; Dimitrov, K.
2008-02-01
Controlled movement and manipulation of magnetic micro- and nanostructures using magnetic forces can give rise to important applications in biomedecine, diagnostics, and immunology. We report controlled magnetophoresis and stretching, in aqueous solution, of a DNA-based dumbbell structure containing magnetic and diamagnetic microspheres. The velocity and stretching of the dumbbell were experimentally measured and correlated with a theoretical model based on the forces acting on individual magnetic beads or the entire dumbbell structures. The results show that precise and predictable manipulation of dumbbell structures is achievable and can potentially be applied to immunomagnetic cell separators.
NASA Astrophysics Data System (ADS)
Lima, N. W.; Gutierres, L. I.; Gonzalez, R. I.; Müller, S.; Thomaz, R. S.; Bringa, E. M.; Papaléo, R. M.
2016-11-01
In this paper, the surface effects of individual heavy ions impacting thin polymerlike films were investigated, using molecular dynamics simulations with the finite extensible nonlinear elastic (FENE) potential to describe the molecular chains. The perturbation introduced by the ions in the lattice was modeled assuming that the initial excitation energy in the ion track is converted into an effective temperature, as in a thermal spike. The track was heated only within the film thickness h , leaving a nonexcited substrate below. The effect of decreasing thickness on cratering and sputtering was evaluated. The results were compared to experimental data of thin polymer films bombarded by MeV-GeV ions and to simulations performed with the Lennard-Jones potential. While several qualitative results observed in the experiments were also seen in the simulations, irrespective of the potential used, there are important differences observed on FENE films. Crater dimensions, rim volume, and sputtering yields are substantially reduced, and a threshold thickness for molecular ejection appears in FENE simulations. This is attributed to the additional restrictions on mass transport out of the excited track region imposed by interchain interactions (entanglements) and by the low mobility of the molten phase induced by the spike.
Diffuse X-ray emission from the Dumbbell Nebula?
NASA Technical Reports Server (NTRS)
Chu, You-Hua; Kwitter, Karen B.; Kaler, James B.
1993-01-01
We have analyzed ROSAT Position Sensitive Proportional Counter pointed observations of the Dumbbell Nebula and find that the previously reported 'extended' X-ray emission is an instrumental electronic ghost image at the softest energy band. At slightly higher energy bands, the image of the Dumbbell is not very different from that of the white dwarf HZ43. We conclude that the X-ray emission of the Dumbbell Nebula comes from its central star. A blackbody model is fitted to the spectrum and the best-fit temperature of not greater than 136,000 +/- 10,000 K is in excellent agreement with the Zanstra temperatures.
Smoothed particle hydrodynamic model for viscoelastic fluids with thermal fluctuations.
Vázquez-Quesada, Adolfo; Ellero, Marco; Español, Pep
2009-05-01
We present a fluid-particle model for a polymer solution in nonisothermal situations. The state of the fluid particles is characterized by the thermodynamic variables and a configuration tensor that describes the underlying molecular orientation of the polymer molecules. The specification of very simple physical mechanisms inspired by the dynamics of single polymer molecules allows one, with the help of the general equation for nonequilibrium reversible-irreversible coupling (GENERIC) formalism, to derive the equations of motion for a set of fluid particles carrying polymer molecules in suspension. In the simplest case of Hookean dumbbells we recover a fluid-particle version of the Oldroyd-B model in which thermal fluctuations are included consistently. Generalization to more complex viscoelastic models, such as finitely extensible nonlinear elastic Peterlin (FENE-P) model, with the proper introduction of thermal fluctuations is straightforward.
Hall Effect on Falkner—Skan Boundary Layer Flow of FENE-P Fluid over a Stretching Sheet
NASA Astrophysics Data System (ADS)
Maqbool, Khadija; Sohail, Ayesha; Manzoor, Naeema; Ellahi, Rahmat
2016-11-01
The Falkner—Skan boundary layer steady flow over a flat stretching sheet is investigated in this paper. The mathematical model consists of continuity and the momentum equations, while a new model is proposed for MHD Finitely Extensible Nonlinear Elastic Peterlin (FENE-P) fluid. The effects of Hall current with the variation of intensity of non-zero pressure gradient are taken into account. The governing partial differential equations are first transformed to ordinary differential equations using appropriate similarity transformation and then solved by Adomian decomposition method (ADM). The obtained results are validated by generalized collocation method (GCM) and found to be in good agreement. Effects of pertinent parameters are discussed through graphs and tables. Comparison with the existing studies is made as a limiting case of the considered problem at the end.
Clusel, C; Ugarte, E; Enjolras, N; Vasseur, M; Blumenfeld, M
1993-01-01
Inhibition of specific transcriptional regulatory proteins is a new approach to control gene expression. Transcriptional activity of DNA-binding proteins can be inhibited by the use of double-stranded (ds) oligodeoxynucleotides that compete for the binding to their specific target sequences in promoters and enhancers. As a model, we used phosphodiester dumbbell oligonucleotides containing a binding site for the liver-enriched transcription factor HNF-1 (Hepatocyte Nuclear Factor 1). Binding affinity of HNF-1 to dumbbell oligonucleotides was the same as that to ds oligonucleotides, as determined by gel retardation assays. HNF-1 dumbbells specifically inhibited in vitro transcription driven by the albumin promoter by more than 90%. HNF-1-dependent activation of a CAT reporter plasmid was specifically inhibited when the HNF-1 dumbbell oligonucleotide was added at nM concentration to transiently transfected C33 cells. On the contrary, HNF-1 ds oligonucleotides, which displayed the same activity as the dumbbell oligonucleotides in the in vitro assays, were no more effective in the ex vivo experiments. These results might reflect the increased stability of the circular dumbbell oligonucleotides towards cellular nuclease degradation, as shown in vitro with nucleolytic enzymes. Dumbbell oligonucleotides containing unmodified phosphodiester bonds may efficiently compete for binding of specific transcription factors within cells, then providing a potential therapeutic tool to control disease-causing genes. Images PMID:7688452
NASA Astrophysics Data System (ADS)
Arditti, D.
2008-12-01
The Dumb-bell Nebula (M27) and the Little Dumb-bell (M76) imaged on October 24?25 by David Arditti. David writes: 'These images were recorded on the same night with the same equipment, so they show the true relationship of sizes.'
Smith, D A
1998-01-01
Force and displacement events from a single myosin molecule interacting with an actin filament suspended between optically trapped beads (Finer, J. T., R. M. Simmons, and J. A. Spudich. 1994. Nature. 368:113-119) can be interpreted in terms of a generalized cross-bridge model that includes the effects of Brownian forces on the beads. Steady-state distributions of force and displacement can be obtained directly from a generalized Smoluchowski equation for Brownian motion of the actin-bead "dumbbell," and time series from Monte Carlo simulations of the corresponding Langevin equation. When the frequency spectrum of Brownian motion extends beyond cross-bridge transition rates, the inverse mean lifetimes of force/displacement pulses are given by cross-bridge rate constants averaged over a Boltzmann distribution of Brownian noise. These averaged rate constants reflect the strain-dependence of the rate constants for the stationary filament, most faithfully at high trap stiffness. Hence, measurements of the lifetimes and displacements of single events as a function of the resting position of the dumbbell can provide a direct test of different cross-bridge theories of muscle contraction. Quantitative demonstrations are given for Huxley models with 1) faster binding or 2) slower dissociation at positive cross-bridge strain. Predictions for other models can be inferred from the averaging procedure. PMID:9826619
A systemic "dumb-bell" haemangiopericytoma.
Tancioni, F; Gaetani, P; Tartara, F; Villani, L; Martelli, A; Rodriguez y Baena, R
1996-01-01
Systemic haemangiopericytoma is a rare soft tissue tumour originating from pericytes which are contractile pericapillary cells, and represents less than one percent of all vascular neoplasms. The most common site of involvement is the thigh followed by the retroperitoneum, while the paraspinal location is very rare. We report the first case of systemic "dumb-bell" haemangiopericytoma illustrated radiologically, which mimick, a dorsal "dumb-bell" neurinoma.
NASA Astrophysics Data System (ADS)
Li, Xiangyu; Gao, Ai; Qiao, Dong
2017-04-01
This paper studies local and global motion in the vicinity of a rotating homogeneous dumbbell-shaped body through the polyhedron model. First, a geometric model of dumbbell-shaped bodies is established. The equilibria points and stabilities thereof are analyzed under different parameters. Then, local motion around equilibrium points is investigated. Based on the continuation method and bifurcation theory, several families of periodic orbits are found around these equilibria. Finally, to better understand the global orbital dynamics of particles around a dumbbell-shaped body, the invariant manifolds associated with periodic orbits are discussed. Four heteroclinic connections are found between equilibria. Using Poincaré sections, trajectories are designed for transfers between different periodic orbits. Those trajectories allow for low-energy global transfer around a dumbbell-shaped body and can be references for designing reconnaissance orbits in future asteroid-exploration missions.
Crystal nucleation of colloidal hard dumbbells.
Ni, Ran; Dijkstra, Marjolein
2011-01-21
Using computer simulations, we investigate the homogeneous crystal nucleation in suspensions of colloidal hard dumbbells. The free energy barriers are determined by Monte Carlo simulations using the umbrella sampling technique. We calculate the nucleation rates for the plastic crystal and the aperiodic crystal phase using the kinetic prefactor as determined from event driven molecular dynamics simulations. We find good agreement with the nucleation rates determined from spontaneous nucleation events observed in event driven molecular dynamics simulations within error bars of one order of magnitude. We study the effect of aspect ratio of the dumbbells on the nucleation of plastic and aperiodic crystal phases, and we also determine the structure of the critical nuclei. Moreover, we find that the nucleation of the aligned close-packed crystal structure is strongly suppressed by a high free energy barrier at low supersaturations and slow dynamics at high supersaturations.
Double dumb-bell calculus in childhood.
Joshi, Prashant; Sarda, Dinesh; Ahmad, Ashraf; Kothari, Paras
2009-01-01
An eight-year old male was admitted with complaints of right scrotal swelling, dysuria and intermittent retention of urine for 10 days. On per-rectal examination, a hard mass was palpable in the posterior urethra. An X-ray (KUB) of the abdomen revealed a double dumb-bell calculus at the base of bladder, extending into the posterior urethra. A cystolithotomy via the suprapubic approach was successfully curative.
Thermodynamically Stable Pickering Emulsions Stabilized by Janus Dumbbells
NASA Astrophysics Data System (ADS)
Tu, Fuquan; Park, Bum Jun; Lee, Daeyeon
2013-03-01
Janus particles have two sides with different, often opposite, surface properties. Janus dumbbell is one type of Janus particles that consists of two partially fused spherical lobes. It is possible to independently control the geometry and surface wettability of Janus dumbbells. Janus dumbbells can also be produced in a large quantity, making them useful for practical applications such as emulsion stabilization. In this work, we calculate the free energy of emulsion formation using amphiphilic Janus dumbbells as solid surfactants. In contrast to kinetically stable emulsions stabilized by homogeneous particles, emulsion stabilized by Janus dumbbells can be thermodynamically stable. There also exists an optimal radius of droplets that can be stabilized by infinite or limited number of amphiphilic dumbbells in the continuous phase. We demonstrate that the optimal radius of dumbbell-stabilized droplets can be predicted based on the volume of the dispersed phase and the volume fraction of dumbbells in the continuous phase. We believe our calculation will provide guidelines for using Janus dumbbells as colloid surfactants to generate stable emulsions.
Tensile test of dumbbell-shaped specimen in thickness direction
NASA Astrophysics Data System (ADS)
Iizuka, Takashi
2016-10-01
Sheet metal forming is widely used in manufacturing shops, and evaluation of forming limit for sheet metal is important. However, specimen shape influences on the fracture of the sheet metal. As one of methods to decrease these effects, an uniaxial tensile test using specimen dumbbell-shaped in thickness direction had been examined using FEM analysis. In this study, actually specimen dumbbell-shaped in thickness direction was fabricated using a new incremental sheet forging method, and uniaxial tensile test was conducted. Load-stroke diagram, fracture morphologies, stress-strain curves and shape after fracture were investigated, and effects of specimen shape were considered. Elongation was larger as using specimen dumbbell-shaped in the width direction. Stress-strain curves until necking occurred were less influenced by specimen shape. However, yield stress decreased and local elongation increased as using specimen dumbbell-shaped in the width direction. The reasons why these tendencies showed were considered in the view of specimen shapes.
Thoracic Extradural Cavernous Hemangioma Mimicking a Dumbbell-Shaped Tumor
Jeong, Won Joo; Choi, Il; Seong, Han Yu
2015-01-01
Dumbbell-shaped spinal extradural cavernous hemangioma is rare. The differential diagnosis of dumbbell-shaped spinal tumors based on magnetic resonance imaging includes schwannoma and lymphoma. Here, we report a dumbbell-shaped spinal extradural cavernous hemangioma with intrathoracic growth on T2-3 in a 64-year-old man complaining of right side infrascapular area back pain with no neurologic deficit. The cavernous hemangioma was resected through combined video-assisted thoracoscopy and laminectomy without a fusion procedure. The patient had tolerable operative wound pain with no neurologic deficit after surgery. Based on magnetic resonance imaging findings and a review of the literature, we discuss cavernous hemangioma among the differential diagnosis of paravertebral dumbbell-shaped spinal tumors and the importance of complete resection. PMID:26279817
DEM simulation of flow of dumbbells on a rough inclined plane
NASA Astrophysics Data System (ADS)
Mandal, Sandip; Khakhar, Devang
2015-11-01
The rheology of non-spherical granular materials such as food grains, sugar cubes, sand, pharmaceutical pills, among others, is not understood well. We study the flow of non-spherical dumbbells of different aspect ratios on a rough inclined plane by using soft sphere DEM simulations. The dumbbells are generated by fusing two spheres together and a linear spring dashpot model along with Coulombic friction is employed to calculate inter-particle forces. At steady state, a uni-directional shear flow is obtained which allows for a detailed study of the rheology. The effect of aspect ratio and inclination angle on mean velocity, volume fraction, shear rate, shear stress, pressure and viscosity profiles is examined. The effect of aspect ratio on probability distribution of angles, made by the major axes of the dumbbells with the flow direction, average angle and order parameter is analyzed. The dense flow rheology is well explained by Bagnold's law and the constitutive laws of JFP model. The dependencies of first and second normal stress differences on aspect ratio are studied. The probability distributions of translational and rotational velocity are analyzed.
Stability of orientationally disordered crystal structures of colloidal hard dumbbells.
Marechal, Matthieu; Dijkstra, Marjolein
2008-06-01
We study the stability of orientationally disordered crystal phases in a suspension of colloidal hard dumbbells using Monte Carlo simulations. For dumbbell bond length L/sigma<0.4 with L the separation of the two spheres of the dumbbell and sigma the diameter of the spheres, we determine the difference in Helmholtz free energy of a plastic crystal with a hexagonal-close-packed (hcp) and a face-centered-cubic (fcc) structure using thermodynamic integration and the lattice-switch Monte Carlo method. We find that the plastic crystal with the hcp structure is more stable than the one with the fcc structure for a large part of the stable plastic crystal regime. In addition, we study the stability of an orientationally disordered aperiodic crystal structure in which the spheres of the dumbbells are on a random-hexagonal-close-packed lattice, and the dumbbells are formed by taking random pairs of neighboring spheres. Using free-energy calculations, we determine the fluid-aperiodic crystal and periodic-aperiodic crystal coexistence regions for L/sigma>0.88 .
NASA Astrophysics Data System (ADS)
Mandal, Sandip; Khakhar, D. V.
2016-10-01
Granular materials handled in industries are typically non-spherical in shape and understanding the flow of such materials is important. The steady flow of mono-disperse, frictional, inelastic dumbbells in two-dimensions is studied by soft sphere, discrete element method simulations for chute flow and shear cell flow. The chute flow data are in the dense flow regime, while the shear cell data span a wide range of solid fractions. Results of a detailed parametric study for both systems are presented. In chute flow, increase in the aspect ratio of the dumbbells results in significant slowing of the flow at a fixed inclination and in the shear cell it results in increase in the shear stress and pressure for a fixed shear rate. The flow is well-described by the μ-I scaling for inertial numbers as high as I = 1, corresponding to solid fractions as low as ϕ = 0.3, where μ is the effective friction (the ratio of shear stress to pressure) and I is the inertial number (a dimensionless shear rate scaled with the time scale obtained from the local pressure). For a fixed inertial number, the effective friction increases by 60%-70% when aspect ratio is increased from 1.0 (sphere) to 1.9. At low values of the inertial number, there is little change in the solid fraction with aspect ratio of the dumbbells, whereas at high values of the inertial number, there is a significant increase in solid fraction with increase in aspect ratio. The dense flow data are well-described by the Jop-Forterre-Pouliquen model [P. Jop et al., Nature 441, 727-730 (2006)] with the model parameters dependent on the dumbbell aspect ratio. The variation of μ with I over the extended range shows a maximum in the range I ∈ (0.4, 0.5), while the solid fraction shows a faster than linear decrease with inertial number. A modified version of the JFP model for μ(I) and a power law model for ϕ(I) is shown to describe the combined data over the extended range of I.
2017-01-01
In this paper, we demonstrate the stabilization of polystyrene microspheres by encapsulating them with dumbbell-shaped colloids with a sticky and a nonsticky lobe. Upon adding a depletant, an effective short ranged attraction is induced between the microspheres and the smaller, smooth lobes of the dumbbells, making those specifically sticky, whereas the interaction with the larger lobes of the dumbbells is considerably less attractive due to their rough surface, which reduces the overlap volume and leaves them nonsticky. The encapsulation of the microspheres by these rough-smooth patchy dumbbells is investigated using a combination of experiments and computer simulations, both resulting in partial coverage of the template particles. For larger microspheres, the depletion attraction is stronger, resulting in a larger fraction of dumbbells that are attached with both lobes to the surface of microspheres. We thus find a template curvature dependent orientation of the dumbbells. In the Monte Carlo simulations, the introduction of such a small, curvature dependent attraction between the rough lobes of the dumbbells resulted in an increased coverage. However, kinetic constraints imposed by the dumbbell geometry seem to prevent optimal packing of the dumbbells on the template particles under all investigated conditions in experiments and simulations. Despite the incomplete coverage, the encapsulation by dumbbell particles does prevent aggregation of the microspheres, thus acting as a colloid-sized steric stabilizer.
Wolters, Joost Robert; Verweij, Joanne E; Avvisati, Guido; Dijkstra, Marjolein; Kegel, Willem K
2017-03-08
In this paper, we demonstrate the stabilization of polystyrene microspheres by encapsulating them with dumbbell-shaped colloids with a sticky and a non-sticky lobe. Upon adding a depletant, an effective short ranged attraction is induced between the microspheres and the smaller, smooth lobes of the dumbbells, making those specifically sticky, whereas the interaction with the larger lobes of the dumbbells is considerably less attractive due to their rough surface, which reduces the overlap volume and leaves them non-sticky. The encapsulation of the microspheres by these rough-smooth patchy dumbbells is investigated using a combination of experiments and computer simulations, both resulting in partial coverage of the template particles. For larger microspheres, the depletion attraction is stronger, resulting in a larger fraction of dumbbells that are attached with both lobes to the surface of microspheres. We thus find a template curvature dependent orientation of the dumbbells. In the Monte Carlo simulations, the introduction of such a small, curvature dependent attraction between the rough lobes of the dumbbells resulted in an increased coverage. However, kinetic constraints imposed by the dumbbell geometry seem to prevent optimal packing of the dumbbells on the template particles under all investigated conditions in experiments and simulations. Despite the incomplete coverage, the encapsulation by dumbbell particles does prevent aggregation of the microspheres, thus acting as a colloid-sized steric stabilizer.
Facile synthesis of dumbbell-shaped multi-compartment nanoparticles.
Doermbach, Karla; Pich, Andrij
2015-05-28
In this article we report on the controlled synthesis of asymmetric lemon-shaped and dumbbell-shaped multi-compartment nanoparticles (MCPs) with a reactive surface and interesting morphology. In our approach we utilize partial coating of hematite ellipsoids with a hydrophobic polymer layer followed by selective silica deposition on the non-coated surface. Ellipsoidal hematite particles provide a non-centric asymmetry, which is strongly enhanced during the seeded emulsion polymerization. The asymmetric growth of polymers on the hematite particle surface is driven by phase separation phenomena, which lead to a reduction of the interfacial tension. We found the tips of the hematite ellipsoids to be uncovered after polymerization. A selective deposition of silica onto the free tips leads to dumbbell-shaped particles with hydrophilic and hydrophobic parts.
Tuning particle geometry of chemically anisotropic dumbbell-shaped colloids.
van Ravensteijn, Bas G P; Kegel, Willem K
2017-03-15
Chemically anisotropic dumbbell-shaped colloids are prepared starting from cross-linked polymer seed particles coated with a chlorinated outer layer. These chlorinated seeds are swollen with monomer. Subsequently, a liquid protrusion is formed on the surface of the seed particle by phase separation between the monomer and the swollen polymer network. Solidification of these liquid lobes by polymerization leads to the desired dumbbell-shaped colloids. The chlorine groups remain confined on the seed lobe of the particles, ensuring chemical anisotropy of the resulting particles. Exploiting the asymmetric distribution of the chemically reactive surface chlorine groups allows for site-specific surface modifications. Here we show that the geometry of the resulting chemically anisotropic dumbbells can be systematically tuned by a number of experimental parameters including the volume of styrene by which the seeds are swollen, the cross-link density of the chlorinated seeds and chemical composition/thickness of the chlorinated coating deposited on the seed particles. Being able to control the particle geometry, and therefore the Janus balance of these chemically anisotropic particles, provides a promising starting point for the synthesis of sophisticated building blocks for future (self-assembly) studies.
Yang, Li-Yun; Dong, Shu-Ying; Sun, Jian-Hui; Feng, Jing-Lan; Wu, Qiu-Hua; Sun, Sheng-Peng
2010-07-15
A novel dumbbell-shaped ZnO photocatalyst was successfully synthesized by microwave heating in the present study. The prepared ZnO photocatalysts were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and UV-Vis absorption spectrum (UV-Vis). The results indicated that the prepared ZnO photocatalyst shows a united dumbbell shape with 2 microm diameter and 5 microm length. The photocatalytic activity of the prepared dumbbell-shaped ZnO photocatalyst was evaluated by the degradation of Methylene Blue (MB) in aqueous solution. The effects of pH, catalyst dosage ([ZnO]) and initial concentration of MB ([MB]) on the photocatalytic degradation efficiency of MB were investigated. An optimum condition was determined as pH 7-8, [ZnO]=1.0 g-ZnO L(-1) and [MB]=15 mg-MB L(-1). Under the optimum condition, the decolorization and TOC removal efficiencies of MB at 75 min reaction time were achieved 99.6% and 74.3%, respectively, which were higher than that by the commercial ZnO powder. In addition, the photocatalytic degradation kinetics of MB was also investigated. The results showed that the photocatalytic degradation kinetics of MB fitted the pseudo-first-order kinetics and the Langmuir-Hinshelwood model.
Effect of the shoulder position on the biceps brachii emg in different dumbbell curls.
Oliveira, Liliam F; Matta, Thiago T; Alves, Daniel S; Garcia, Marco A C; Vieira, Taian M M
2009-01-01
Incline Dumbbell Curl (IDC) and Dumbbell Preacher Curl (DPC) are two variations of the standard Dumbbell Biceps Curl (DBC), generally applied to optimize biceps brachii contribution for elbow flexion by fixing shoulder at a specific angle. The aim of this study is to identify changes in the neuromuscular activity of biceps brachii long head for IDC, DPC and DBC exercises, by taking into account the changes in load moment arm and muscle length elicited by each dumbbell curl protocol. A single cycle (concentric-eccentric) of DBC, IDC and DPC, was applied to 22 subjects using a submaximal load of 40% estimated from an isometric MVC test. The neuromuscular activity of biceps brachii long head was compared by further partitioning each contraction into three phases, according to individual elbow joint range of motion. Although all protocols elicited a considerable level of activation of the biceps brachii muscle (at least 50% of maximum RMS), the contribution of this muscle for elbow flexion/extension varied among exercises. The submaximal elbow flexion (concentric) elicited neuro muscular activity up to 95% of the maximum RMS value during the final phase of IDC and DBC and 80% for DPC at the beginning of the movement. All exercises showed significant less muscle activity for the elbow extension (eccentric). The Incline Dumbbell Curl and the classical Dumbbell Biceps Curl resulted in similar patterns of biceps brachii activation for the whole range of motion, whereas Dumbbell Preacher Curl elicited high muscle activation only for a short range of elbow joint angle. Key pointsThe Incline Dumbbell Curl and the Dumbbell Biceps Curl resulted in a considerable neuromuscular effort throughout the whole elbow range of motion.The Incline Dumbbell Curl and the Dumbbell Biceps Curl may be preferable for the improvement of biceps brachii force in training programs.
Effect of the shoulder position on the biceps brachii emg in different dumbbell curls
Oliveira, Liliam F.; Matta, Thiago T.; Alves, Daniel S.; Garcia, Marco A.C.; Vieira, Taian M.M.
2009-01-01
Incline Dumbbell Curl (IDC) and Dumbbell Preacher Curl (DPC) are two variations of the standard Dumbbell Biceps Curl (DBC), generally applied to optimize biceps brachii contribution for elbow flexion by fixing shoulder at a specific angle. The aim of this study is to identify changes in the neuromuscular activity of biceps brachii long head for IDC, DPC and DBC exercises, by taking into account the changes in load moment arm and muscle length elicited by each dumbbell curl protocol. A single cycle (concentric-eccentric) of DBC, IDC and DPC, was applied to 22 subjects using a submaximal load of 40% estimated from an isometric MVC test. The neuromuscular activity of biceps brachii long head was compared by further partitioning each contraction into three phases, according to individual elbow joint range of motion. Although all protocols elicited a considerable level of activation of the biceps brachii muscle (at least 50% of maximum RMS), the contribution of this muscle for elbow flexion/extension varied among exercises. The submaximal elbow flexion (concentric) elicited neuro muscular activity up to 95% of the maximum RMS value during the final phase of IDC and DBC and 80% for DPC at the beginning of the movement. All exercises showed significant less muscle activity for the elbow extension (eccentric). The Incline Dumbbell Curl and the classical Dumbbell Biceps Curl resulted in similar patterns of biceps brachii activation for the whole range of motion, whereas Dumbbell Preacher Curl elicited high muscle activation only for a short range of elbow joint angle. Key pointsThe Incline Dumbbell Curl and the Dumbbell Biceps Curl resulted in a considerable neuromuscular effort throughout the whole elbow range of motion.The Incline Dumbbell Curl and the Dumbbell Biceps Curl may be preferable for the improvement of biceps brachii force in training programs. PMID:24150552
Lateral parascapular extrapleural approach for single-stage excision of dumb-bell neurofibroma.
O'Reilly, G; Jackowski, A; Weiner, G; Thomas, D
1994-01-01
An excision of a T1 dumb-bell neurofibroma via a single-stage lateral parascapular extrapleural approach is described. The different surgical approaches that can be used to approach dumb-bell tumours are reviewed, together with the relevant literature.
Quantum anomalous Hall effect in stable dumbbell stanene
NASA Astrophysics Data System (ADS)
Zhang, Huisheng; Zhang, Jiayong; Zhao, Bao; Zhou, Tong; Yang, Zhongqin
2016-02-01
Topological property of the dumbbell (DB) stanene, more stable than the stanene with a honeycomb lattice, is investigated by using ab initio methods. The magnetic DB stanene demonstrates an exotic quantum anomalous Hall (QAH) effect due to inversion of the Sn spin-up px,y and spin-down pz states. The QAH gap is found to be opened at Γ point rather than the usual K and K' points, beneficial to observe the effect in experiments. When a 3% tensile strain is applied, a large nontrivial gap (˜50 meV) is achieved. Our results provide another lighthouse for realizing QAH effects in two-dimensional systems.
Facile synthesis of dumbbell-shaped multi-compartment nanoparticles
NASA Astrophysics Data System (ADS)
Doermbach, Karla; Pich, Andrij
2015-05-01
In this article we report on the controlled synthesis of asymmetric lemon-shaped and dumbbell-shaped multi-compartment nanoparticles (MCPs) with a reactive surface and interesting morphology. In our approach we utilize partial coating of hematite ellipsoids with a hydrophobic polymer layer followed by selective silica deposition on the non-coated surface. Ellipsoidal hematite particles provide a non-centric asymmetry, which is strongly enhanced during the seeded emulsion polymerization. The asymmetric growth of polymers on the hematite particle surface is driven by phase separation phenomena, which lead to a reduction of the interfacial tension. We found the tips of the hematite ellipsoids to be uncovered after polymerization. A selective deposition of silica onto the free tips leads to dumbbell-shaped particles with hydrophilic and hydrophobic parts.In this article we report on the controlled synthesis of asymmetric lemon-shaped and dumbbell-shaped multi-compartment nanoparticles (MCPs) with a reactive surface and interesting morphology. In our approach we utilize partial coating of hematite ellipsoids with a hydrophobic polymer layer followed by selective silica deposition on the non-coated surface. Ellipsoidal hematite particles provide a non-centric asymmetry, which is strongly enhanced during the seeded emulsion polymerization. The asymmetric growth of polymers on the hematite particle surface is driven by phase separation phenomena, which lead to a reduction of the interfacial tension. We found the tips of the hematite ellipsoids to be uncovered after polymerization. A selective deposition of silica onto the free tips leads to dumbbell-shaped particles with hydrophilic and hydrophobic parts. Electronic supplementary information (ESI) available: TEM images of silica coating without a polymer layer, experiments for removal of the polymer by solvent extraction, TEM images of spherical α-Fe2O3 nanoparticles with an asymmetric PSGD coating, and additional FESEM
Dumbbell Gallbladder Cholecystitis on Tc-99m Diisopropyliminodiacetic acid Hepatobiliary Imaging
Fakhri, Asif Ali; Rodrigue, Paul David; Hussain, Aun; Taiyebi, Abbas
2017-01-01
We present a case of a 79-year-old immunocompromised female admitted for abdominal pain and sepsis, who had an abdominal computed tomography (CT) showing distal gallbladder fundus wall thickening, pericholecystic edema, and a right posteroinferior hepatic abscess. Subsequent hepatobiliary scintigraphy with Tc-99m diisopropyliminodiacetic acid showed gallbladder filling of the proximal gallbladder fundus, yet no radiotracer filling of the distal gallbladder fundus. Further correlation with the initial CT showed a partial gallbladder stricture and a resultant altered morphology resembling a dumbbell-shaped gallbladder. Percutaneous cholangiogram also confirmed this dumbbell morphology. Nonfilling of radiotracer into the distal end of the dumbbell gallbladder correlating with CT findings of focal gallbladder inflammation indicated that there was a focal inflammation suggesting a distal dumbbell gallbladder cholecystitis. This case demonstrates a unique finding of focal inflammatory pathology involving an anatomic variant - the dumbbell-shaped gallbladder, and the challenges this anatomic variant presents in hepatobiliary scintigraphy image interpretation. PMID:28242983
Yu, Han; Jiang, Xiaoou; Tan, Kar Tong; Hang, Liting; Patzel, Volker
2015-10-15
Genetic therapy holds great promise for the treatment of inherited or acquired genetic diseases; however, its breakthrough is hampered by the lack of suitable gene delivery systems. Dumbbell-shaped DNA minimal vectors represent an attractive, safe alternative to the commonly used viral vectors which are fraught with risk, but dumbbell generation appears to be costly and time-consuming. We developed a new PCR-based method for dumbbell production which comprises only two steps. First, PCR amplification of the therapeutic expression cassette using chemically modified primers to form a ready-to-ligate DNA structure; and second, a highly efficient intramolecular ligation reaction. Compared with conventional strategies, the new method produces dumbbell vectors more rapidly, with higher yields and purity, and at lower costs. In addition, such produced small hairpin RNA expressing dumbbells triggered superior target gene knockdown compared with conventionally produced dumbbells or plasmids. Our novel method is suitable for large-scale dumbbell production and can facilitate clinical applications of this vector system.
Takahashi, Hayato; Nagao, Daisuke; Watanabe, Kanako; Ishii, Haruyuki; Konno, Mikio
2015-05-26
Monodisperse, nonmagnetic, asymmetrical composite dumbbells in a suspension of magnetic nanoparticles (ferrofluid) were aligned by application of an external magnetic field to the ferrofluid. The asymmetrical composite dumbbells were prepared by two-step soap-free emulsion polymerization consisting of the first polymerization to coat spherical silica cores with cross-linked poly(methyl methacrylate) (PMMA) shell and the second polymerization to protrude a polystyrene (PSt) lobe from the core-shell particles. A chain structure of nonmagnetic dumbbells oriented to the applied magnetic field was observed at nanoparticle content of 2.0 vol % and field strengths higher than 1.0 mT. A similar chain structure of the dumbbells was observed under application of alternating electric field at strengths higher than 50 V/mm. Parallel and orthogonally combined applications of the electric and magnetic fields were also conducted to examine independence of the electric and magnetic applications as operational factors in the dumbbell assembling. Dumbbell chains stiffer than those in a single application of external field were formed in the parallel combined application of electric and magnetic fields. The orthogonal combination of the different applied fields could form a magnetically aligned chain structure of the nonmagnetic dumbbells oriented to the electric field. The present work experimentally indicated that the employment of inverse magnetorheological effect for nonmagnetic, anisotropic particles can be a useful method for the simultaneous controls over the orientation and the positon of anisotropic particles in their assembling.
The dumb-bell's restricted, photogravitational, circular three-body problem
NASA Astrophysics Data System (ADS)
Roman, Rodica; Oproiu, Tiberiu
2008-09-01
We study the dumb-bell's planar motion in the frame of the photogravitational restricted three body problem. The main topic of this paper is the connection between the translation and the spin motion of the dumb-bell, under the action of a photogravitational field generated by a binary system. The dumb-bell's equations of motion in the orbital plane are established, first using an inertial reference system, and then a rotating one. A prime integral of Jacobi type is found. Then are analyzed the equipotential surfaces and the equilibrium points. A geometrical feature of equilibrium points is established.
Preparation and Optical Properties ZnO Dumb-Bell Like Microcrystals
NASA Astrophysics Data System (ADS)
Shetty, Amitha; Nanda, Karuna Kar
2011-07-01
We report here the growth of dumb-bell like ZnO microcrystals via a simple chemical route. The X-ray diffraction (XRD) results show that the ZnO dumb-bell is crystalline in nature. The transmission electron microscopy (TEM) and scanning electron microscopy (SEM) studies reveal that the size of the dumb-bell is of ˜1 m in length 500 nm in diameter. The photoluminescence spectra show a luminescence both in the uv and visible region covering green to red region of the electromagnetic spectrum. So this can be a promising material for light-emitting diode (LED) applications.
Double dumbbell shaped AgNi alloy by pulsed electrodeposition
Dhanapal, K.; Vasumathi, M.; Santhi, Kalavathy; Narayanan, V. Stephen, A.
2014-01-28
Silver-Nickel is the well-known thermally immiscible system that makes them quite complex for the formation of alloy. This kind of alloy can be attained from electrodeposition method. In the present work, AgNi alloy was synthesized by pulsed electrodeposition in a single bath two electrode system with the use of anodic alumina membrane. The prepared AgNi alloy and pure Ag were characterized with X-ray Diffraction (XRD) for structural confirmation, Scanning Electron Microscopy (SEM) for morphological, and magnetic properties by Vibrating Sample Magnetometer, respectively. The X-ray Diffraction study shows the formation of cubic structure for pure Ag. SEM analysis reveals the double dumbbell morphology for AgNi alloy and spherically agglomeration for pure silver. Hysteresis behaviour from VSM measurement indicates that the AgNi alloy have good ferro-magnetic properties.
Preparation and photocatalytic property of a novel dumbbell-shaped ZnO microcrystal photocatalyst.
Sun, Jian-Hui; Dong, Shu-Ying; Wang, Yong-Kui; Sun, Sheng-Peng
2009-12-30
A novel dumbbell-shaped ZnO microcrystal photocatalyst was successfully synthesized by hydrothermal method in the present study. The prepared ZnO photocatalyst was systematically characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), thermogravimetric analysis (TG-DTA), photoluminescence spectrum (PL) and UV-vis absorption spectrum (UV-vis). The characterizations of dumbbell-shaped ZnO were also compared with the commercial ZnO. The results show that the prepared ZnO photocatalyst has a unique dumbbell shape and it belongs to the hexagonal wurtzite family. In addition, the photocatalytic activity of the prepared dumbbell-shaped ZnO microcrystal photocatalyst was evaluated by the degradation of three different kinds of dyes wastewater (Crystal Violet, Methyl Violet and Methylene Blue). After 75 min reaction, the decolourization efficiencies of the three kinds of dyes wastewater achieved 68.0%, 99.0% and 98.5%, the TOC removal efficiencies achieved 43.2%, 59.4% and 70.6%, respectively. Compared to commercial ZnO, 16-22% higher TOC removal efficiency was obtained by the dumbbell-shaped ZnO. The results indicated that the prepared dumbbell-shaped ZnO microcrystal photocatalyst showed good photocatalytic activity and it could be considered as a promising photocatalyst for dyes wastewater treatment.
Dumbbell-like Au-Fe3O4 nanoparticles: a new nanostructure for supercapacitors.
Liu, Sheng; Guo, Shaojun; Sun, Shouheng; You, Xiao-Zeng
2015-03-21
Monodispersed dumbbell-like Au-Fe3O4 nanoparticles (NPs) were synthesized and studied for use in supercapacitors. These dumbbell NPs show Au/Fe3O4-size dependent capacitive behaviors and the 7-14 nm Au-Fe3O4 NPs have the best specific capacitance of 464 F g(-1) at 1 A g(-1) and capacity retention of 86.4% after 1000 cycles, much larger than pure Fe3O4 NPs (160 F g(-1) and 72.8% retention). This capacitive enhancement is believed to arise from the Au-induced increase in electron transfer across the dumbbell-like NPs. Thise report demonstrates a new strategy to enhance oxide NP capacitance for applications in high performance supercapacitors.
NASA Astrophysics Data System (ADS)
Partheepan, G.; Sehgal, D. K.; Pandey, R. K.
2006-12-01
An inverse finite element algorithm is established to extract the tensile constitutive properties such as Young's modulus, yield strength and true stress-true strain diagram of a material in a virtually non-destructive manner. Standard test methods for predicting mechanical properties require the removal of large size material samples from the in-service component, which is impractical. To circumvent this situation, a new dumb-bell shaped miniature specimen has been designed and fabricated which can be used for evaluation of properties for a material or component. Also test fixtures were developed to perform a tension test on this proposed miniature specimen in a testing machine. The studies have been conducted in low carbon steel, die steel and medium carbon steel. The output from the miniature test, namely, load-elongation diagram, is obtained and used for the proposed inverse finite element algorithm to find the material properties. Inverse finite element modelling is carried out using a 2D plane stress analysis. The predicted results are found to be in good agreement with the experimental results.
Development of novel decoy oligonucleotides: advantages of circular dumb-bell decoy.
Tomita, Naruya; Tomita, Tetsuya; Yuyama, Kazuhiko; Tougan, Takahiro; Tajima, Tsuyoshi; Ogihara, Toshio; Morishita, Ryuichi
2003-04-01
The inhibition of specific transcription regulatory proteins is a novel approach to regulate gene expression. The transcriptional activities of DNA binding proteins can be inhibited by the use of double-stranded oligonucleotides (ODNs) that compete for binding to their specific target sequences in promoters and enhancers. Transfection of this cis-element double-stranded ODN, referred to as decoy ODN, has been reported to be a powerful tool that provides a new class of anti-gene strategies to gene therapy and permits examination of specific gene regulation. We have demonstrated the usefulness of this decoy ODN strategy in animal models of restenosis, myocardial infarction, glomerulonephritis and rheumatoid arthritis. However, one of the major limitations of decoy ODN technology is the rapid degradation of phosphodiester ODNs by intracellular nucleases. To date, several different types of double-stranded decoy ODNs have been developed to overcome this issue. Circular dumb-bell (CD) double-stranded decoy ODNs that were developed to resolve this issue have attracted a high level of interest. In this review, the applications of decoy ODN strategy and the advantages of modified CD double-stranded decoy ODNs will be discussed.
Two-way coupling of finitely extensible nonlinear elastic dumbbells with a turbulent shear flow
NASA Astrophysics Data System (ADS)
Peters, Thomas; Schumacher, Jörg
2007-06-01
We present numerical studies for finitely extensible nonlinear elastic dumbbells which are dispersed in a turbulent plane shear flow at moderate Reynolds number. The polymer ensemble is described on the mesoscopic level by a set of stochastic ordinary differential equations with Brownian noise. The dynamics of the Newtonian solvent is determined by the Navier-Stokes equations. Momentum transfer of the dumbbells with the solvent is implemented by an additional volume forcing term in the Navier-Stokes equations, such that both components of the resulting viscoelastic fluid are connected by a two-way coupling. The dynamics of the dumbbells is given then by Newton's second law of motion including small inertia effects. We investigate the dynamics of the flow for different degrees of dumbbell elasticity and inertia, as given by Weissenberg and Stokes numbers, respectively. For the parameters accessible in our study, the magnitude of the feedback of the polymers on the macroscopic properties of turbulence remains small as quantified by the global energy budget and the Reynolds stresses. A reduction of the turbulent drag by up to 20% is observed for the larger particle inertia. The angular statistics of the dumbbells shows an increasing alignment with the mean flow direction for both, increasing elasticity and inertia. This goes in line with a growing asymmetry of the probability density function of the transverse derivative of the streamwise turbulent velocity component. We find that dumbbells get stretched preferentially in regions where vortex stretching or biaxial strain dominate the local dynamics and topology of the velocity gradient tensor.
Hydrophobic self-assembly of a perylenediimide-linked DNA dumbbell into supramolecular polymers.
Neelakandan, Prakash P; Pan, Zhengzheng; Hariharan, Mahesh; Zheng, Yan; Weissman, Haim; Rybtchinski, Boris; Lewis, Frederick D
2010-11-10
The self-assembly of DNA dumbbell conjugates possessing hydrophobic perylenediimide (PDI) linkers separated by an eight-base pair A-tract has been investigated. Cryo-TEM images obtained from dilute solutions of the dumbbell in aqueous buffer containing 100 mM NaCl show the presence of structures corresponding to linear end-to-end assemblies of 10-30 dumbbell monomers. The formation of assemblies of this size is consistent with analysis of the UV-vis and fluorescence spectra of these solutions for the content of PDI monomer and dimer chromophores. Assembly size is dependent upon the concentration of dumbbell and salt as well as the temperature. Kinetic analysis of the assembly process by means of salt-jump stopped-flow measurements shows that it occurs by a salt-triggered isodesmic mechanism in which the rate constants for association and dissociation in 100 mM NaCl are 3.2 × 10(7) M(-1)s(-1) and 1.0 s(-1), respectively, faster than the typical rate constants for DNA hybridization. TEM and AFM images of samples deposited from solutions having higher concentrations of dumbbell and NaCl display branched assemblies with linear regions >1 μm in length and diameters indicative of the formation of small bundles of dumbbell end-to-end assemblies. These observations provide the first example of the use of hydrophobic association for the assembly of small DNA duplex conjugates into supramolecular polymers and larger branched aggregates.
Result of MHI 2-Cell Seamless Dumb-Bell Cavity Vertical Test
Okihira, K.; Hara, H.; Ikeda, N.; Inoue, F.; Sennyu, K.; Geng, Rongli; Rimmer, Robert A.; Kako, E.
2014-12-01
MHI have supplied several 9-cell cavities for STF (R&D of ILC project at KEK) and have been considering production method for stable quality and cost reduction, seamless dumb-bell cavity was one of them. We had fabricated a 2 cell seamless dumb-bell cavity for cost reduction and measured RF performance in collaboration with JLab, KEK and MHI. Surface treatment recipe for ILC was applied for MHI 2-cell cavity and vertical test was performed at JLab. The cavity reached Eacc=32.4MV/m after BCP and EP. Details of the result are reported.
Au@Ag core/shell cuboids and dumbbells: Optical properties and SERS response
NASA Astrophysics Data System (ADS)
Khlebtsov, Boris N.; Liu, Zhonghui; Ye, Jian; Khlebtsov, Nikolai G.
2015-12-01
Recent studies have conclusively shown that the plasmonic properties of Au nanorods can be finely controlled by Ag coating. Here, we investigate the effect of asymmetric silver overgrowth of Au nanorods on their extinction and surface-enhanced Raman scattering (SERS) properties for colloids and self-assembled monolayers. Au@Ag core/shell cuboids and dumbbells were fabricated through a seed-mediated anisotropic growth process, in which AgCl was reduced by use of Au nanorods with narrow size and shape distribution as seeds. Upon tailoring the reaction rate, monodisperse cuboids and dumbbells were synthesized and further transformed into water-soluble powders of PEGylated nanoparticles. The extinction spectra of AuNRs were in excellent agreement with T-matrix simulations based on size and shape distributions of randomly oriented particles. The multimodal plasmonic properties of the Au@Ag cuboids and dumbbells were investigated by comparing the experimental extinction spectra with finite-difference time-domain (FDTD) simulations. The SERS efficiencies of the Au@Ag cuboids and dumbbells were compared in two options: (1) individual SERS enhancers in colloids and (2) self-assembled monolayers formed on a silicon wafer by drop casting of nanopowder solutions mixed with a drop of Raman reporters. By using 1,4-aminothiophenol Raman reporter molecules, the analytical SERS enhancement factor (AEF) of the colloidal dumbbells was determined to be 5.1×106, which is an order of magnitude higher than the AEF=4.0×105 for the cuboids. This difference can be explained by better fitting of the dumbbell plasmon resonance to the excitation laser wavelength. In contrast to the colloidal measurements, the AEF=5×107 of self-assembled cuboid monolayers was almost twofold higher than that for dumbbell monolayers, as determined with rhodamine 6G Raman reporters. According to TEM data and electromagnetic simulations, the better SERS response of the self-assembled cuboids is due to uniform
Synthesis of dumbbell-like ZnO microcrystals via a simple solution route
2012-01-01
Uniform dumbbell-like ZnO microcrystals had been successfully fabricated on a large scale via a facile solution technique under mild conditions. Obtained ZnO, with length of 1.2 to 1.6 μm and diameters of 350 to 600 nm, exhibited well-defined dumbbell-like morphology and hexagonal wurtzite structure and grew along the [001] direction. Effects of the reactant concentration on the sizes and morphologies of the ZnO products had been investigated, indicating that the reactant concentration played a crucial role in determining final sizes and shapes of the samples. In addition, the growth process of the dumbbell-like ZnO microcrystals was studied, and a possible formation mechanism was proposed. Furthermore, the optical properties of ZnO samples obtained at various reaction times were also investigated by photoluminescence (PL) spectroscopy. The PL spectra of the as-prepared dumbbell-like ZnO microcrystals showed a strong UV emission peak. PMID:22963609
A giant dumbbell shaped vesico-prostatic urethral calculus: a case report and review of literature.
Prabhuswamy, Vinod Kumar; Tiwari, Rahul; Krishnamoorthy, Ramakrishnan
2013-01-01
Calculi in the urethra are an uncommon entity. Giant calculi in prostatic urethra are extremely rare. The decision about treatment strategy of calculi depends upon the size, shape, and position of the calculus and the status of the urethra. If the stone is large and immovable, it may be extracted via the perineal or the suprapubic approach. In most of the previous reported cases, giant calculi were extracted via the transvesical approach and external urethrotomy. A 38-year-old male patient presented with complaints of lower urinary tract symptoms. Further investigations showed a giant urethral calculus secondary to stricture of bulbo-membranous part of the urethra. Surgical removal of calculus was done via transvesical approach. Two calculi were found and extracted. One was a huge dumbbell calculus and the other was a smaller round calculus. This case was reported because of the rare size and the dumbbell nature of the stone. Giant urethral calculi are better managed by open surgery.
A rare case of dumb-bell lipoma of the sole.
Satish, Chetan
2011-12-01
A rare case of dumb-bell shaped lipoma of sole of foot in a middle aged lady which had crippled her life for almost a decade in-spite of multiple surgeries. She was initially misdiagnosed to have a corn on her sole and had undergone 3 surgeries spanning about 5 years. Due to the big size of the soft tissue swelling an MRI was done which showed a dumb-bell shaped swelling of foot. A major portion of swelling was lying deep to the plantar fascia after breaching the fascia. She underwent an excision of the swelling and is free of any recurrence after 2 years. She is now able to walk with a normal gait.
Primary retroperitoneal transitional cell carcinoma presenting as a dumb-bell tumour.
Basu, S; Ansari, M; Gupta, S; Kumar, A
2009-11-01
We report a retroperitoneal transitional cell carcinoma arising from the primitive urogenital remnants of a 56-year-old married Indian woman. She presented with a huge cystic mass in the hypogastrium and right iliac fossa, which extended into the right thigh as a massive dumb-bell tumour. On exploration, it was found not to be arising from any known retroperitoneal structure. The mass was excised, and the histopathology confirmed transitional cell carcinoma with positive margins. Though she received postoperative chemotherapy with cyclophosphamide, adriamycin and cisplatin, she developed extensive local recurrence and hepatic secondaries, and succumbed to the disease after ten months of follow-up. We highlight the rarity of the disease, its atypical presentation as a cystic dumb-bell lump, its diagnostic challenges and aggressive behaviour, and review the literature on primary retroperitoneal transitional cell carcinomas.
Dumb-bell galaxies in southern clusters: Catalog and preliminary statistical results
NASA Technical Reports Server (NTRS)
Vettolani, G.; Gregorini, L.; Parma, P.; Deruiter, H. R.
1990-01-01
The dominant galaxy of a rich cluster is often an object whose formation and evolution is closely connected to the dynamics of the cluster itself. Hoessel (1980) and Schneider et al. (1983) estimate that 50 percent of the dominant galaxies are either of the dumb-bell type or have companions at projected distances less than 20 kpc, which is far in excess of the number expected from chance projection (see also Rood and Leir 1979). Presently there is no complete sample of these objects, with the exception of the listing of dumb-bell galaxies in BM type I and I-II clusters in the Abell statistical sample of Rood and Leir (1979). Recent dynamical studies of dumb-bell galaxies in clusters (Valentijn and Casertano, 1988) still suffer from inhomogeneity of the sample. The fact that it is a mixture of optically and radio selected objects may have introduced an unknown biases, for instance if the probability of radio emission is enhanced by the presence of close companions (Stocke, 1978, Heckman et al. 1985, Vettolani and Gregorini 1988) a bias could be present in their velocity distribution. However, this situation is bound to improve: a new sample of Abell clusters in the Southern Hemisphere has been constructed (Abell et al., 1988 hereafter ACO), which has several advantages over the original northern catalog. The plate material (IIIaJ plates) is of better quality and reaches fainter magnitudes. This makes it possible to classify the cluster types with a higher degree of accuracy, as well as to fainter magnitudes. The authors therefore decided to reconsider the whole problem constructing a new sample of dumb-bell galaxies homogeneously selected from the ACO survey. Details of the classification criteria are given.
Heterojunction double dumb-bell Ag2Te-Te-Ag2Te nanowires
NASA Astrophysics Data System (ADS)
Som, Anirban; Pradeep, T.
2012-07-01
Growth of isolated axial heterojunction nanowires by a solution phase growth process is reported. The dumb-bell shaped nanowires contain two silver telluride sections at the extremes joined by a tellurium section. Reaction of silver nitrate with tellurium NWs in aqueous solution at a molar ratio of 1 : 1 leads to the formation of amorphous partially silver reacted Te NWs. Low temperature (75 °C) solution phase annealing of these silver deficient NWs results in phase segregation producing crystalline Ag2Te and Te phases with clear phase boundaries along the wire axis. Structural characterization of these dumb-bell shaped NWs was performed with different microscopic and spectroscopic tools. Solution phase silver concentration over the course of annealing indicated leaching of silver into the solution during the formation of biphasic NWs. Similar Ag : Te ratios were observed in both partially silver reacted Te NWs and phase segregated Ag2Te-Te-Ag2Te NWs and this was attributed to redeposition of leached silver on the amorphous NW tips which eventually resulted in complete phase segregation. Successful integration of different chemical components in single NWs is expected to open up new application possibilities as physical and chemical properties of the heterostructure can be exploited.Growth of isolated axial heterojunction nanowires by a solution phase growth process is reported. The dumb-bell shaped nanowires contain two silver telluride sections at the extremes joined by a tellurium section. Reaction of silver nitrate with tellurium NWs in aqueous solution at a molar ratio of 1 : 1 leads to the formation of amorphous partially silver reacted Te NWs. Low temperature (75 °C) solution phase annealing of these silver deficient NWs results in phase segregation producing crystalline Ag2Te and Te phases with clear phase boundaries along the wire axis. Structural characterization of these dumb-bell shaped NWs was performed with different microscopic and spectroscopic
Cervical extradural and extraspinal ependymoma mimicking dumb-bell schwannoma: an unusual tumor.
Ramesh, V G; Karthikeyan, K V; Rao, K Ramesh; Balasubramanian, C
2013-01-01
Ependymomas are common in intramedullary location and extradural location of the spinal cord is very rare. A few cases in the lumbosacral region have been reported. This report presents a cervical dumb-bell ependymoma with a small intraspinal extradural component and a large extraspinal component in the posterior triangle of the neck. The tumor was excised in two stages. This is probably the first such case report in the cervical region in the world literature. Possible histogenesis of ependymoma in this location is also discussed.
Baba, H; Okumura, Y; Furusawa, N; Omori, H; Kawahara, H; Fujita, T; Katayama, K; Noriki, S
1998-08-01
We report an instructive case of a 65-year-old man who presented with a dumb-bell shaped tuberculous abscess across the greater sciatic notch bilaterally compressing both sciatic nerves. Clinical symptoms progressed slowly and mimicked lumbar radiculopathy, thus delaying an accurate diagnosis. Anterolateral retroperitoneal and posterolateral gluteal approaches of the greater sciatic notch as well as the acetabulum on both sides were followed in order to provide safe viewing and resection of the abscess. The abscess wall was adherent to the sciatic nerve and surrounding blood vessels. The symptoms completely disappeared after resection of the abscess.
NASA Astrophysics Data System (ADS)
Hirabayashi, Masatoshi; Kawaguchi, Junichiro
Since a few decades ago, varieties of asteroids have been discovered and observed in detail, stimulating scientists' interests. As for the closed-orbit dynamics about these objects, the dynamics around a simple model and an estimated shape obtained by light curve and radar observations have been actively studied. For the simple model, since the dynamics can easily be understood, several model were sug-gested. Chauvineau et al. (1993) numerically studied orbits on the equilateral plane of a highly elongated body, by using a triaxial ellipsoid model, the two-connected-mass model, and the mass-distribution model. Scheeres (1994) considered the closed-orbit dynamics about a uni-formly rotating triaxial ellipsoid. As for the two-mass-rotating system, Prieto-Llanos et al. (1994) investigated the dynamics around an elongated body in the case of the ratio of the gravitational to centripetal force more than 1 and applied to the Mars-Phobos system. On the other hand, using the same model, Hirabayashi et al. (2010) derived the stability condition about collinear equilibrium points for the ratio less than 1, the fast rotating case, applying it to Asteroid 2000EB14. Analyses with the spherical harmonic function (Kaula, 1966) have also been presented. Scheeres et al. (1996) studied closed orbits to Asteroid Castalia, taking into account coefficients up to order 16 obtained by Hudson and Ostro (1994). They pointed out that for the Castalia case C20 and C22 are important factors. Closed orbits about Toutatis, a non-uniformly rotating asteroid, was also analyzed by Scheeres et al. (1998). Also, Scheeres et al.(2000) studied the dynamics in orbit about Asteroid Eros, a target of NEAR mission. Yoshikawa et al. (1997), on the other hand, suggested the orbital stability around an irregularly shaped body in terms of the inclination angle, considering C20 and C22. The paper studies orbital disturbances around an irregular body such as a contact binary body or a dumbbell shaped body and
Park, Jin Soo; Shirachi, Isao; Sato, Kimiaki; Ando, Noriyuki; Nagata, Kensei
2005-01-01
The authors present the case of a 60-year-old woman with a neck lipoma that developed dumb-bell extradural extension, causing radiculopathy. To the best of the authors' knowledge, this is the first report of a lipoma originating in the neck with dumb-bell extradural extension through the intervertebral foramen and into the spinal canal. The lipoma was first excised from the foramen via a posterior approach to allow decompression of the nerve roots. The remaining lipomatous tissue was then resected via an anterior approach to avoid the region around the vertebral artery.
Heterojunction double dumb-bell Ag₂Te-Te-Ag₂Te nanowires.
Som, Anirban; Pradeep, T
2012-08-07
Growth of isolated axial heterojunction nanowires by a solution phase growth process is reported. The dumb-bell shaped nanowires contain two silver telluride sections at the extremes joined by a tellurium section. Reaction of silver nitrate with tellurium NWs in aqueous solution at a molar ratio of 1 : 1 leads to the formation of amorphous partially silver reacted Te NWs. Low temperature (75 °C) solution phase annealing of these silver deficient NWs results in phase segregation producing crystalline Ag(2)Te and Te phases with clear phase boundaries along the wire axis. Structural characterization of these dumb-bell shaped NWs was performed with different microscopic and spectroscopic tools. Solution phase silver concentration over the course of annealing indicated leaching of silver into the solution during the formation of biphasic NWs. Similar Ag : Te ratios were observed in both partially silver reacted Te NWs and phase segregated Ag(2)Te-Te-Ag(2)Te NWs and this was attributed to redeposition of leached silver on the amorphous NW tips which eventually resulted in complete phase segregation. Successful integration of different chemical components in single NWs is expected to open up new application possibilities as physical and chemical properties of the heterostructure can be exploited.
Luczak, Joshua; Bosak, Andy; Riemann, Bryan L
2013-01-01
Previous research has compared the effects of trunk inclination angle on muscle activation using barbells and Smith machines in men. Whether similar effects occur with the use of dumbbells or in women remains unknown. The purpose was to compare upper extremity surface electromyographical (EMG) activity between dumbbell bench, incline, and shoulder presses. Dominate arm EMG data were recorded for collegiate-aged female resistance trained individuals (n = 12) and novice female resistance trained exercisers (n = 12) from which average EMG amplitude for each repetition phase (concentric, eccentric) was computed. No significant differences were found between experienced and novice resistance trained individuals. For the upper trapezius and anterior deltoid muscles, shoulder press activation was significantly greater than incline press which in turn was significantly greater than bench press across both phases. The bench and incline presses promoted significantly greater pectoralis major sternal activation compared to the shoulder press (both phases). While pectoralis major clavicular activation during the incline press eccentric phase was significantly greater than both the bench and shoulder presses, activation during the bench press concentric phase promoted significantly greater activation than the incline press which in turn was significantly greater than the shoulder press. These results provide evidence for selecting exercises in resistance and rehabilitation programs.
Formation of the dumbbell-like nucleus of a comet by sublimation
NASA Astrophysics Data System (ADS)
Vavilov, Dmitrii; Medvedev, Yurii; Zatitskiy, Pavel
2016-10-01
The nucleus of the comet 67P/Churyumov-Gerasimenko is an elongated body with a deep groove around the middle. There are also other comets that look like dumbbells (e.g. 103P/Hartley 2, 19P/Borrelly, 1P/Halley). Two most probable interpretations are discussed in the scientific society. The first hypothesis explains the creation of such an object as sticking of two cometesimals during the process of formation. The second one suggests that the sublimation process can change the nucleus shape and make a groove in the middle.In this work we consider the second hypothesis. It was assumed that the spin axis of the nucleus is perpendicular to the plane of the cometary orbit and that initially the nucleus shape is a sphere. Thus, the problem is represented as a differential equation, which describes the change of the cometary nucleus. We solved this equation analytically. It was shown that initially a convex cometary nucleus (e.g. a sphere), consisting of homogeneous material, can not be transformed into a dumbbell-like body by the influence of sublimation. However, assuming that the density in the centre of the nucleus is less than on the surface, a groove can arise on the equator of the cometary nucleus as a result of sublimation.
Validation of a dumbbell body sway test in olympic air pistol shooting.
Mon, Daniel; Zakynthinaki, Maria S; Cordente, Carlos A; Monroy Antón, Antonio; López Jiménez, David
2014-01-01
We present and validate a test able to provide reliable body sway measurements in air pistol shooting, without the use of a gun. 46 senior male pistol shooters who participated in Spanish air pistol championships participated in the study. Body sway data of two static bipodal balance tests have been compared: during the first test, shooting was simulated by use of a dumbbell, while during the second test the shooters own pistol was used. Both tests were performed the day previous to the competition, during the official training time and at the training stands to simulate competition conditions. The participantś performance was determined as the total score of 60 shots at competition. Apart from the commonly used variables that refer to movements of the shooters centre of pressure (COP), such as COP displacements on the X and Y axes, maximum and average COP velocities and total COP area, the present analysis also included variables that provide information regarding the axes of the COP ellipse (length and angle in respect to X). A strong statistically significant correlation between the two tests was found (with an interclass correlation varying between 0.59 and 0.92). A statistically significant inverse linear correlation was also found between performance and COP movements. The study concludes that dumbbell tests are perfectly valid for measuring body sway by simulating pistol shooting.
Dumbbell Defects in FeSe Films: A Scanning Tunneling Microscopy and First-Principles Investigation.
Huang, Dennis; Webb, Tatiana A; Song, Can-Li; Chang, Cui-Zu; Moodera, Jagadeesh S; Kaxiras, Efthimios; Hoffman, Jennifer E
2016-07-13
The properties of iron-based superconductors (Fe-SCs) can be varied dramatically with the introduction of dopants and atomic defects. As a pressing example, FeSe, parent phase of the highest-Tc Fe-SC, exhibits prevalent defects with atomic-scale "dumbbell" signatures as imaged by scanning tunneling microscopy (STM). These defects spoil superconductivity when their concentration exceeds 2.5%. Resolving their chemical identity is a prerequisite to applications such as nanoscale patterning of superconducting/nonsuperconducting regions in FeSe as well as fundamental questions such as the mechanism of superconductivity and the path by which the defects destroy it. We use STM and density functional theory to characterize and identify the dumbbell defects. In contrast to previous speculations about Se adsorbates or substitutions, we find that an Fe-site vacancy is the most energetically favorable defect in Se-rich conditions and reproduces our observed STM signature. Our calculations shed light more generally on the nature of Se capping, the removal of Fe vacancies via annealing, and their ordering into a √5 × √5 superstructure in FeSe and related alkali-doped compounds.
Nam, Kyoung Hyup; Ahn, Hyo Yeoung; Cho, Jeong Su; Kim, Yeoung Dae; Choi, Byung Kwan; Han, In Ho
2017-01-01
Objective This study was conducted to assess the surgical results of one-stage posterior minimal laminectomy and video-assisted thoracoscopic surgery (VATS) for the treatment of thoracic dumbbell tumor and to describe its precise technique. In addition, we investigated the technique’s usefulness and limitations. Methods Seven cases of thoracic dumbbell tumor (two men and five women, mean age, 43 years) were analyzed retrospectively. Pathological findings included schwannoma in four patients, neurofibroma in two patients, and hemangioma in one patient. The location of tumors varied from T2/3 to T12/L1. Dumbbell tumors were resected by one-stage operation using posterior laminectomy followed by VATS without instrumentation. Clinical data were reviewed. Results The mean follow-up period was 25 months (range, 3–58 months), and the operative time ranged from 255 to 385 min (mean, 331 min), with estimated blood loss ranging from 110 to 930 mL (mean, 348 mL). The tumor was completely resected without instrumentation and postoperative instability in all cases. Postoperative complications included atelectasis and facial anhydrosis in one case each. Conclusion One-stage posterior minimal laminectomy and VATS may be a safe and less invasive technique for removal of thoracic dumbbell tumor without instability. This method has the advantage of early ambulation and rapid recovery because it reduces blood loss and postoperative pain. PMID:28264248
Gel-limited synthesis of dumbbell-like Fe3O4-Ag composite microspheres and their SERS applications
NASA Astrophysics Data System (ADS)
Zhang, Xiaoli; Niu, Chunyu; Wang, Yongqiang; Zhou, Shaomin; Liu, Jin
2014-10-01
A novel gel-limited strategy was developed to synthesize dumbbell-like Fe3O4-Ag composite microspheres through a simple one-pot solvothermal method. In such a reaction system, a special precursor solution containing oleic, water, ethanol and silver ions was used and transformed into a bulk gel under heating at the very beginning of the reaction, thus all the subsequent reactions proceeded in the interior of the gel. The gel-limited reactions had two advantages, on the one hand, the magnetic Fe3O4 microspheres were fixed in the gel which avoided them aggregating together, whereas on the other hand, the silver ions stored in the gel could be gradually released and tended to diffuse towards the nearest Fe3O4 microsphere, which favored the generation of a dumbbell-like Fe3O4-Ag structure. From the time-dependent experiments under optimal conditions, the typical growth process of dumbbell-like structures clearly demonstrated that a silver seed first appeared on the surface of a single Fe3O4 microsphere, which then grew bigger slowly and finally formed a dumbbell-like Fe3O4-Ag structure. Moreover, the formation of the gel was found to be strongly affected by the ratio of water and ethanol in the precursor solution, which further influenced the morphologies of the Fe3O4-Ag microspheres. Furthermore, the effect of lattice match between Fe3O4 and Ag on the final products was also proven from the control experiments by using a template with a different surface crystalline structure. When used as SERS substrates, the final dumbbell-like Fe3O4-Ag microspheres show fast magnetic separation and the selective detection of thiram for the surface capped oleic chain during the growth process.A novel gel-limited strategy was developed to synthesize dumbbell-like Fe3O4-Ag composite microspheres through a simple one-pot solvothermal method. In such a reaction system, a special precursor solution containing oleic, water, ethanol and silver ions was used and transformed into a bulk gel
Uchida, K; Baba, H; Maezawa, Y; Chen, Q; Imura, S
1996-01-01
The case history of a patient with a dumb-bell neurilemmoma arising from the L5 nerve root is described. The tumour extended into the outlet of the neural foramen at L5-S1 on the left and was also compressing the dural sac and the S1 nerve root. A limited laminotomy at L4-5 and L5-S1, with preservation of the neural arch, was followed by microsurgical medial foraminotomy at L5-S1 which allowed visualisation of the nerve root and enucleation of the tumour. The technique maintains stability of the posterior elements and spinal movement, and is recommended for the removal of this type of tumour.
Zang, XiaoFei; Shi, Cheng; Chen, Lin; Cai, Bin; Zhu, YiMing; Zhuang, SongLin
2015-03-10
Metamaterials, artificial electromagnetic media consisting of periodical subwavelength metal-based micro-structures, were widely suggested for the absorption of terahertz (THz) waves. However, they have been suffered from the absorption of THz waves just in the single-frequency owing to its resonance features. Here, in this paper, we propose a simple periodical structure, composed of two 90 degree crossed dumbbell-shaped doped-silicon grating arrays, to demonstrate broadband THz wave absorption. Our theoretical and experimental results illustrate that THz waves can be efficiently absorbed more than 95% ranging from 0.92 THz to 2.4 THz. Such an ultra-wideband polarization-independent THz absorber is realized mainly based on the mechanisms of the anti-reflection effect together with the [±1, 0]-order and [0, ±1]-order grating diffractions. The application of our investigation can be extend to THz couplers, filters, imaging, and so on.
System noise analysis of the dumbbell tethered satellite for gravity-gradient measurements
NASA Technical Reports Server (NTRS)
Colombo, G.
1979-01-01
An analysis of the dumbbell gravity gradiometer concept for measuring short wavelength variations in the earth's gravity gradient is presented. Variations in the gradient are recorded by measuring tension variations in a vertically stabilized satellite consisting of heavy masses connected by a long wire or rod. Tension noise arises from the excitation of various mechanical oscillations of the system. The principal noise sources that were identified are fluctuations in atmospheric drag heating and drag force resulting from density variations and winds. Approximate analytical expressions are presented for the tension noise as a function of the system design parameters for various possible configurations. Computer simulations using numerical integration were performed to study the tension noise for several sample cases. Three designs consistent with Shuttle launch capabilities are discussed.
Stability solutions of a dumbbell-like system in an elliptical orbit
NASA Astrophysics Data System (ADS)
Souza dos Santos, Denilson Paulo; Brito de Aguiã Morant, Simão António da Rocha e.; Guerman, Anna D.; Burov, Alexander A.
2015-10-01
A dumbbell-like system is analyzed, considering two mass points connected with a massless and rigid tether with length variations, and the center of mass described by Keplerian orbits. This kind of system, in a certain type of configuration, is a simple conceptualization of the space elevator. The system motion is obtained with the Lagrangian Formulation in a Central Gravitational Field, and the perturbations of motion are neglected. Laws of control are considered for the angle of systems rotation around the center of mass. Those include uniform rotations or no rotation at all. Stability conditions were obtained for the first case, analyzing its neighborhood and using Floquet Theory. The results shown there are regions of eccentricities were stability is found. Lastly, a dynamic numerical simulator was created, where the implementation of the results could be tested. The dynamic behavior of the system showed regular and chaotic properties.
Enhancing Fullerene-Based Solar Cell Lifetimes by Addition of a Fullerene Dumbbell**
Schroeder, Bob C; Li, Zhe; Brady, Michael A; Faria, Gregório Couto; Ashraf, Raja Shahid; Takacs, Christopher J; Cowart, John S; Duong, Duc T; Chiu, Kar Ho; Tan, Ching-Hong; Cabral, João T; Salleo, Alberto; Chabinyc, Michael L; Durrant, James R; McCulloch, Iain
2014-01-01
Cost-effective, solution-processable organic photovoltaics (OPV) present an interesting alternative to inorganic silicon-based solar cells. However, one of the major remaining challenges of OPV devices is their lack of long-term operational stability, especially at elevated temperatures. The synthesis of a fullerene dumbbell and its use as an additive in the active layer of a PCDTBT:PCBM-based OPV device is reported. The addition of only 20 % of this novel fullerene not only leads to improved device efficiencies, but more importantly also to a dramatic increase in morphological stability under simulated operating conditions. Dynamic secondary ion mass spectrometry (DSIMS) and TEM are used, amongst other techniques, to elucidate the origins of the improved morphological stability. PMID:25264304
Patterson, Jeffrey M; Vigotsky, Andrew D; Oppenheimer, Nicole E; Feser, Erin H
2015-01-01
Training the bench press exercise on a traditional flat bench does not induce a level of instability as seen in sport movements and activities of daily living. Twenty participants were recruited to test two forms of instability: using one dumbbell rather than two and lifting on the COR bench compared to a flat bench. Electromyography (EMG) amplitudes of the pectoralis major, middle trapezius, external oblique, and internal oblique were recorded and compared. Differences in range of motion (ROM) were evaluated by measuring an angular representation of the shoulder complex. Four separate conditions of unilateral bench press were tested while lifting on a: flat bench with one dumbbell, flat bench with two dumbbells, COR Bench with one dumbbell, and COR Bench with two dumbbells. The results imply that there are no differences in EMG amplitude or ROM between the COR bench and traditional bench. However, greater ROM was found to be utilized in the single dumbbell condition, both in the COR bench and the flat bench.
Patterson, Jeffrey M.; Oppenheimer, Nicole E.; Feser, Erin H.
2015-01-01
Training the bench press exercise on a traditional flat bench does not induce a level of instability as seen in sport movements and activities of daily living. Twenty participants were recruited to test two forms of instability: using one dumbbell rather than two and lifting on the COR bench compared to a flat bench. Electromyography (EMG) amplitudes of the pectoralis major, middle trapezius, external oblique, and internal oblique were recorded and compared. Differences in range of motion (ROM) were evaluated by measuring an angular representation of the shoulder complex. Four separate conditions of unilateral bench press were tested while lifting on a: flat bench with one dumbbell, flat bench with two dumbbells, COR Bench with one dumbbell, and COR Bench with two dumbbells. The results imply that there are no differences in EMG amplitude or ROM between the COR bench and traditional bench. However, greater ROM was found to be utilized in the single dumbbell condition, both in the COR bench and the flat bench. PMID:26528421
Srivastava, Dharmendra Kumar; Singh, Deepak; Tiwari, Bhuwan Chandra; Awasthi, Namarata; Hussain, Nuzhat
2014-02-01
We report a rare case of benign thoracic dumb-bell tumor in the upper posterior mediastinum, which was successfully removed by posterolateral thoracotomy and foraminotomy, using intraoperative monitoring of spinal motor-evoked potentials. This technique has many advantages including minimal morbidity and mortality, a single incision, one-step complete resection with adequate exposure, spinal stabilization, avoidance of laminectomy, nerve root identification, and good predicted postoperative function.
Mode-locked all-fiber dumbbell-shaped laser based on a nonlinear amplifying optical loop mirror.
Yang, Bing-Ke; Chen, Sheng-Ping; Chen, He; Qi, Xue; Hou, Jing
2016-10-01
We report a hybrid passively mode-locked dumbbell-shaped fiber laser based on a nonlinear optical loop mirror and a nonlinear amplifying optical fiber-loop mirror. The laser produced noise-like pulses with repetition rate of 8.85 MHz and pulse energy of 16.2 and 26.4 nJ from the two output ports, respectively. Several interesting phenomena are observed and briefly discussed in the paper.
Oryza sativa H+-ATPase (OSA) is Involved in the Regulation of Dumbbell-Shaped Guard Cells of Rice.
Toda, Yosuke; Wang, Yin; Takahashi, Akira; Kawai, Yuya; Tada, Yasuomi; Yamaji, Naoki; Feng Ma, Jian; Ashikari, Motoyuki; Kinoshita, Toshinori
2016-06-01
The stomatal apparatus consists of a pair of guard cells and regulates gas exchange between the leaf and atmosphere. In guard cells, blue light (BL) activates H(+)-ATPase in the plasma membrane through the phosphorylation of its penultimate threonine, mediating stomatal opening. Although this regulation is thought to be widely adopted among kidney-shaped guard cells in dicots, the molecular basis underlying that of dumbbell-shaped guard cells in monocots remains unclear. Here, we show that H(+)-ATPases are involved in the regulation of dumbbell-shaped guard cells. Stomatal opening of rice was promoted by the H(+)-ATPase activator fusicoccin and by BL, and the latter was suppressed by the H(+)-ATPase inhibitor vanadate. Using H(+)-ATPase antibodies, we showed the presence of phosphoregulation of the penultimate threonine in Oryza sativa H(+)-ATPases (OSAs) and localization of OSAs in the plasma membrane of guard cells. Interestingly, we identified one H(+)-ATPase isoform, OSA7, that is preferentially expressed among the OSA genes in guard cells, and found that loss of function of OSA7 resulted in partial insensitivity to BL. We conclude that H(+)-ATPase is involved in BL-induced stomatal opening of dumbbell-shaped guard cells in monocotyledon species.
Borade, P; Joshi, K U; Gokarna, A; Lerondel, G; Jejurikar, S M
2016-01-15
In this paper, we report the synthesis of dumbbell-shaped ZnO structures and their subsequent transformation into perfect hexagonal tubes by the extended chemical bath deposition (CBD) method, retaining all advantages such as reproducibility, simplicity, quickness and economical aspect. Well-dispersed sub-micron-sized dumbbell-shaped ZnO structures were synthesized on a SiO2/Si substrate by the CBD method. As an extension of the CBD process the synthesized ZnO dumbbells were exposed to the evaporate coming out of the chemical bath for a few minutes (simply by adjusting the height of the deposit so that it remained just above the solution) to convert them into hexagonal tubes via the dissolution process. The possible dissolution mechanism responsible for the observed conversion is discussed. The optical properties (photo-luminescence) recorded at low temperature on both the structures showed an intense, sharp excitonic peak located at ∼370 nm. The improved intensity and low FWHM of the UV peak observed in the hexagonal tubular structures assures high optical quality, and hence can be used for optoelectronic applications.
NASA Astrophysics Data System (ADS)
Borade, P.; Joshi, K. U.; Gokarna, A.; Lerondel, G.; Jejurikar, S. M.
2016-01-01
In this paper, we report the synthesis of dumbbell-shaped ZnO structures and their subsequent transformation into perfect hexagonal tubes by the extended chemical bath deposition (CBD) method, retaining all advantages such as reproducibility, simplicity, quickness and economical aspect. Well-dispersed sub-micron-sized dumbbell-shaped ZnO structures were synthesized on a SiO2/Si substrate by the CBD method. As an extension of the CBD process the synthesized ZnO dumbbells were exposed to the evaporate coming out of the chemical bath for a few minutes (simply by adjusting the height of the deposit so that it remained just above the solution) to convert them into hexagonal tubes via the dissolution process. The possible dissolution mechanism responsible for the observed conversion is discussed. The optical properties (photo-luminescence) recorded at low temperature on both the structures showed an intense, sharp excitonic peak located at ∼370 nm. The improved intensity and low FWHM of the UV peak observed in the hexagonal tubular structures assures high optical quality, and hence can be used for optoelectronic applications.
Oryza sativa H+-ATPase (OSA) is Involved in the Regulation of Dumbbell-Shaped Guard Cells of Rice
Toda, Yosuke; Wang, Yin; Takahashi, Akira; Kawai, Yuya; Tada, Yasuomi; Yamaji, Naoki; Feng Ma, Jian; Ashikari, Motoyuki; Kinoshita, Toshinori
2016-01-01
The stomatal apparatus consists of a pair of guard cells and regulates gas exchange between the leaf and atmosphere. In guard cells, blue light (BL) activates H+-ATPase in the plasma membrane through the phosphorylation of its penultimate threonine, mediating stomatal opening. Although this regulation is thought to be widely adopted among kidney-shaped guard cells in dicots, the molecular basis underlying that of dumbbell-shaped guard cells in monocots remains unclear. Here, we show that H+-ATPases are involved in the regulation of dumbbell-shaped guard cells. Stomatal opening of rice was promoted by the H+-ATPase activator fusicoccin and by BL, and the latter was suppressed by the H+-ATPase inhibitor vanadate. Using H+-ATPase antibodies, we showed the presence of phosphoregulation of the penultimate threonine in Oryza sativa H+-ATPases (OSAs) and localization of OSAs in the plasma membrane of guard cells. Interestingly, we identified one H+-ATPase isoform, OSA7, that is preferentially expressed among the OSA genes in guard cells, and found that loss of function of OSA7 resulted in partial insensitivity to BL. We conclude that H+-ATPase is involved in BL-induced stomatal opening of dumbbell-shaped guard cells in monocotyledon species. PMID:27048369
Peng, Bo; Zhang, Hao; Shao, Hezhu; Xu, Yuanfeng; Zhang, Rongjun; Lu, Hongliang; Zhang, David Wei; Zhu, Heyuan
2016-08-17
The dumbbell structure of two-dimensional group IV material offers alternatives to grow thin films for diverse applications. Thermal properties are important for these applications. We obtain the lattice thermal conductivity of low-buckled (LB) and dumbbell (DB) silicene by using first-principles calculations and the Boltzmann transport equation for phonons. For LB silicene, the calculated lattice thermal conductivity with naturally occurring isotope concentrations is 27.72 W/mK. For DB silicene, the calculated value is 2.86 W/mK. The thermal conductivity for DB silicene is much lower than LB silicene due to stronger phonon scattering. Our results will induce further theoretical and experimental investigations on the thermoelectric (TE) properties of DB silicene. The size-dependent thermal conductivity in both LB and DB silicene is investigated as well for designing TE devices. This work sheds light on the manipulation of phonon transport in two-dimensional group IV materials by dumbbell structure formed from the addition of adatoms.
Yin, Mengchen; Huang, Quan; Sun, Zhengwang; Gao, Xin; Chen, Guanghui; He, Shaohui; Xia, Ye; Ma, Junming; Mo, Wen; Xiao, Jianru
2017-03-01
Dumbbell tumors can not only cause the compression of cervical cord and nerve root, but also invade the important structures and the surrounding organs, causing great harm to the patient. Toyama classification that is commonly used has not been evaluated and still requires independent validation.The objectives of this study were to evaluate and analyze the interobserver reliability and intraobserver reproducibility of Toyama classification system, explore the differences, discover the shortages, and evaluate the clinical value for diagnosis.One hundred sixty-five consecutive patients of a cervical dumbbell tumor with complete clinical and radiologic data were enrolled. Six surgeons determined the classification according to Toyama system. The classification was repeated 12 weeks later. Correlation coefficient (ICC) and kappa coefficient (κ) test were used to determine interobserver reliability and intraobserver reproducibility.The interobserver reliability for Toyama classification was moderate with a value of 0.432. The interobserver reproducibility for Toyama classification was moderate with a value of 0.608.The Toyama classification has landmark value in clinical practice, but it is a relatively cumbersome system. This study shows that it has low reliability and reproducibility. Accordingly, surgical management of the resection of dumbbell cervical tumors raises several problems, including preservation of the cervical nerve root, control of the vertebral artery, and maintenance of spine. There is a need to optimize the classification in the future.
Yin, Mengchen; Huang, Quan; Sun, Zhengwang; Gao, Xin; Chen, Guanghui; He, Shaohui; Xia, Ye; Ma, Junming; Mo, Wen; Xiao, Jianru
2017-01-01
Abstract Dumbbell tumors can not only cause the compression of cervical cord and nerve root, but also invade the important structures and the surrounding organs, causing great harm to the patient. Toyama classification that is commonly used has not been evaluated and still requires independent validation. The objectives of this study were to evaluate and analyze the interobserver reliability and intraobserver reproducibility of Toyama classification system, explore the differences, discover the shortages, and evaluate the clinical value for diagnosis. One hundred sixty-five consecutive patients of a cervical dumbbell tumor with complete clinical and radiologic data were enrolled. Six surgeons determined the classification according to Toyama system. The classification was repeated 12 weeks later. Correlation coefficient (ICC) and kappa coefficient (κ) test were used to determine interobserver reliability and intraobserver reproducibility. The interobserver reliability for Toyama classification was moderate with a value of 0.432. The interobserver reproducibility for Toyama classification was moderate with a value of 0.608. The Toyama classification has landmark value in clinical practice, but it is a relatively cumbersome system. This study shows that it has low reliability and reproducibility. Accordingly, surgical management of the resection of dumbbell cervical tumors raises several problems, including preservation of the cervical nerve root, control of the vertebral artery, and maintenance of spine. There is a need to optimize the classification in the future. PMID:28272207
Matsuo, T; Suzuki, M
1999-06-01
The effects of dumb-bell exercise (aerobic-resistance exercise) with and without low calorie diet (LCD) therapy on resting metabolic rate (RMR), diet-induced thermogenesis (DIT) and body composition were studied in 12 mildly obese women aged 19-20 years. The subjects were randomly assigned to one of the following two groups: dumb-bell exercise with LCD (DEx + LCD group), and dumb-bell exercise only (DEx group). The subjects performed dumb-bell exercises with pairs of 2 kg dumb-bells every day after dinner for approximately 20 min. In the DEx + LCD group, subjects also received a liquid-formula diet based on a commercially available diet supplement, Micro Diet, for two of their three daily meals. Thus, they were restricted to approximately 4.18 MJ of energy intake per day for 12 weeks. Subjects underwent several measurements (body composition, RMR and DIT tests) before commencing the experiment and again after 12 weeks while still dieting. During the 12 week experimental period, body weight and body fat decreased significantly in both the DEx + LCD and the DEx groups without reducing fat free mass (FFM). The decreases in body weight and body fat were significantly larger in the LCD + DEx group than in the DEx group. These results suggest that dumb-bell exercise decreases body weight and body fat without reducing FFM in relation to increasing RMR and DIT. Micro Diet LCD may strengthen the effect of dumb-bell exercise on body weight and body fat, but weaken the effects on RMR and DIT.
Chen, Jinyang; Liu, Yucheng; Ji, Xinghu; He, Zhike
2016-09-15
In this work, a versatile dumbbell molecular (DM) probe was designed and employed in the sensitively homogeneous bioassay. In the presence of target molecule, the DM probe was protected from the digestion of exonucleases. Subsequently, the protected DM probe specifically bound to the intercalation dye and resulted in obvious fluorescence signal which was used to determine the target molecule in return. This design allows specific and versatile detection of diverse targets with easy operation and no sophisticated fluorescence labeling. Integrating the idea of target-protecting DM probe with adenosine triphosphate (ATP) involved ligation reaction, the DM probe with 5'-end phosphorylation was successfully constructed for ATP detection, and the limitation of detection was found to be 4.8 pM. Thanks to its excellent selectivity and sensitivity, this sensing strategy was used to detect ATP spiked in human serum as well as cellular ATP. Moreover, the proposed strategy was also applied in the visual detection of ATP in droplet-based microfluidic platform with satisfactory results. Similarly, combining the principle of target-protecting DM probe with streptavidin (SA)-biotin interaction, the DM probe with 3'-end biotinylation was developed for selective and sensitive SA determination, which demonstrated the robustness and versatility of this design.
Molecular hydrogen maps of extended planetary nebulae - the Dumbbell, the Ring, and NGC 2346
Zuckerman, B.; Gatley, I.
1988-01-01
The 3.8-m United Kingdom Infrared Telecsope at Mauna Kea was used to obtain complete H2 maps of three extended planetary nebulae (PNs) that are representative of two of the most common PN morphologies, bow tie and bipolar ring: the Dumbbell (NGC 6853), the Ring (NGC 6720), and the NG 2346, are discussed. The results of map analysis indicates that the S(1) emission from H2 closely follows the optical morphology of the three nebulae. The H2 emission is more extended than the main emitting mass of ionized gas and, in NGCC 2346, there is evidence for a dense torus of hot H2 surrounding the central star. The H2 emissionl appears to be shock-excited. Examinations of existing H2 measurements indicate that strong H2 emission is preferentially present in PNs that lie at small galactic latitude, implying that massive main-sequence stars produce ionization-bounded PNs, whereas low-mass stars produce density-bounded PNs. Thus, maps of H2 emission may not only be used to determine whether a given PN is ionization-bounded or density-bounded, but also to estimate the mass of the progenitor star. 83 references.
Sawant, Ajit; Pawar, Prakash; Kasat, Gaurav Vinod; Kapadnis, Lomesh
2016-01-01
Complicated Vesicovaginal Fistulae (VVF) is prevalent in developing countries following obstetric injury. We report a rare case of a large dumbbell shaped vesicovaginal calculus measuring 7x 4.6cm in a patient with recurrent, complicated VVF managed successfully in two stages 6 weeks apart. Holmium laser (30 Watt) cystolithotripsy was used to break the vesical portion of the stone at the waist of the dumbbell, followed by delivery of vaginal part of the stone. Trans-abdominal VVF repair (O’Connor method) with omental interposition flap with right side ureteric reimplant was done after six weeks. Our case was unique because of occurrence of a larger sized fistula after a gynaecological surgery. She had developed larger stone (weight more than190gm- vaginal component) into the fistula tract. Also she had undergone multiple failed VVF repair attempts before. Use of holmium laser energy to break the stone was unique which minimized the morbidity of the first procedure leading to early recovery followed by staged repair of fistula after six weeks. PMID:27790520
Ruíz, Alberto; Morera-Boado, Cercis; Almagro, Luis; Coro, Julieta; Maroto, Enrique E; Herranz, María Ángeles; Filippone, Salvatore; Molero, Dolores; Martínez-Álvarez, Roberto; Garcia de la Vega, José M; Suárez, Margarita; Martín, Nazario
2014-04-18
New [60]fullerene-steroid conjugates (4-6) have been synthesized by 1,3-dipolar cycloaddition and Bingel-Hirsch cyclopropanation reactions from suitably functionalized epiandrosterone and [60]fullerene. Since a new stereocenter is created in the formation of the Prato monoaduct, two different diastereomers were isolated by HPLC (4, 5) whose absolute configurations were assigned according to the highly reliable "sector rule" on fullerenes. A further reaction of the malonate-containing diastereomer 5 with a second C60 molecule has afforded dumbbell fullerene 6 in which the two fullerene units are covalently connected through an epiandrosterone moiety. The new compounds have been spectroscopically characterized and their redox potentials, determined by cyclic voltametry, reveal three reversible reduction waves for hybrids 4 and 5, whereas these signals are split in dumbbell 6. Theoretical calculations at semiempirical (AM1) and single point B3LYP/6-31G(d) levels have predicted the most stable conformations for the hybrid compounds (4-6), showing the importance of the chlorine atom on the D ring of the steroid. Furthermore, TDDFT calculations have allowed assignments of the experimentally determined circular dichroism (CD) of the [60]fullerene-steroid hybrids based on the sign and position of the Cotton effects, despite the exceptionally large systems under study.
NASA Astrophysics Data System (ADS)
Shi, Wei; Liu, Xinyu; Wei, Chao; Xu, Zhichuan J.; Sim, Stanley Siong Wei; Liu, Linbo; Xu, Chenjie
2015-10-01
Heterogeneous Au-Fe3O4 dumbbell nanoparticles (NPs) are composed of Au NPs and Fe3O4 NPs that bring in optical and magnetic properties respectively. This article reports the engineering of Au-Fe3O4 NPs as gene carriers for magnetic gene transfection as well as contrast agents for micro-optical coherence tomography (μOCT). As a proof-of-concept, Au-Fe3O4 NPs are used to deliver the green fluorescent protein to HEK 293T cells and their entrance into the cells is monitored through μOCT.Heterogeneous Au-Fe3O4 dumbbell nanoparticles (NPs) are composed of Au NPs and Fe3O4 NPs that bring in optical and magnetic properties respectively. This article reports the engineering of Au-Fe3O4 NPs as gene carriers for magnetic gene transfection as well as contrast agents for micro-optical coherence tomography (μOCT). As a proof-of-concept, Au-Fe3O4 NPs are used to deliver the green fluorescent protein to HEK 293T cells and their entrance into the cells is monitored through μOCT. Electronic supplementary information (ESI) available. See DOI: 10.1039/c5nr05459a
Le Garff, Erwan; Delannoy, Yann; Mesli, Vadim; Berthezene, Jean Marie; Morbidelli, Philippe; Hédouin, Valéry
2015-12-01
Firearm suicides are frequent and well described in the forensic literature, particularly in Europe and the United States. However, the use of homemade and improvised firearms is less well described. The present case reports a suicide with an original improvised gun created using an air-compressed pellet gun and a dumbbell pipe. The aims of this study were to describe the scene, the external examination of the corpse, the body scan, and the autopsy; to understand the mechanism of death; and to compare the results with a review of the forensic literature to highlight the epidemiology of homemade firearm use, the tools used for homemade and improvised firearms in suicides versus homicides, and the manners in which homemade firearms are used (homicide or suicide, particularly in complex suicide cases).
Wei, Hua; Tang, Suming; Hu, Tianyu; Zhao, Guojie; Guan, Yifu
2016-01-01
Dumbbell probe (DP) attracts increasing interests in rolling circle amplification (RCA). A universal DP production method through cleavage-ligation of hairpin was proposed and optimized. The production is characterized by restriction endonuclease (RE)-induced cleavage ends ligation. It has the advantage of phosphorylation-free, splint-free and purification-free. To optimize designing, we found that the position of RE cleavage sequence in the stem and the primer position in the loop affected the formation and amplification of DP obviously. Both sticky and blunt ends cleaved by RE produce DP efficiently. Moreover, we introduced this DP into circle to circle (C2C) RCA based on the same cleavage-ligation principle, and acquired high sensitivity. By combining a two-ligation design and the C2C strategy, specificity for detecting let-7 family members was increased extremely. Furthermore, coreaction of different steps facilitated convenient formation and amplification process of DP. PMID:27385060
Ojika, T; Imaizumi, M; Watanabe, H; Nishimura, M; Sakakibara, M; Mizuno, S; Watanabe, T; Hiroura, M; Abe, T; Kato, F
1993-10-01
A successfully treated case of a seven-year-old girl with a left intrathoracic Dumb-bell ganglioneuroma is reported. The tumor was 10 cm in diameter. Preoperative angiography revealed that the location of tumor was very close to the Adamkiewicz artery. In order to prevent the artery from damaging, spinal evoked potentials (SEP) was used during the surgery and was very useful for monitoring the spinal cord. Although SEP has often been employed in spine surgery, the literature on the use of it for posterior mediastinal tumor is scarce. It is considered that SEP is very useful for not damaging the feeding artery to the spinal cord, and for preventing the postoperative neurologic complications.
Matsumoto, Yoshihiro; Matsunobu, Tomoya; Harimaya, Katsumi; Kawaguchi, Kenichi; Hayashida, Mitsumasa; Okada, Seiji; Doi, Toshio; Iwamoto, Yukihide
2016-01-01
AIM To study the clinical findings and characteristic features in sciatic notch dumbbell tumors (SNDTs). METHODS We retrospectively reviewed the clinical outcomes and characteristic features of consecutive cases of SNDTs (n = 8). RESULTS Buttock masses occurred in three patients with SNDT (37.5%). Severe buttock tenderness and pain at rest were observed in seven patients with SNDTs (87.5%). Remarkably, none of the patients with SNDTs experienced back pain. Mean tumor size was 8.4 ± 2.0 cm (range, 3.9 to 10.6 cm) and part of the tumor mass was detected in 2 patients in the sagittal view of lumbar magnetic resonance imaging (MRI). CONCLUSION The clinical information regarding to SNDTs is scarce. The authors consider that above mentioned characteristic findings may facilitate the suspicion of pelvic pathology and a search for SNDT by MRI or computed tomography should be considered in patients presenting with sciatica without evidence of spinal diseases. PMID:27777884
Krishnan, Prasad; Kartikueyan, Rajaraman; Kumar, Soumen K
2016-01-01
A 27-year-old male patient with neurofibromatosis type 1 who was operated on for a dumbbell neurofibroma of the cervical spine developed transient respiratory difficulty due to postoperative unilateral diaphragmatic palsy. This report emphasizes the need for preoperative assessment of residual function in involved non-limb roots, the role of intraoperative monitoring to take a decision on root sacrifice, and the need for optimizing respiratory function preoperatively, and describes a complication rarely reported in literature.
Lu Yang; Luo Yongsong; Kong Dezhi; Zhang Deyang; Jia Yonglei; Zhang Xinwei
2012-02-15
The controllable synthesis of novel dumbbell-like BiVO{sub 4} hierarchical nanostructures has been successfully obtained via a simple hydrothermal route. The as-synthesized products were studied by X-ray powder diffraction, scanning electron microscopy, transmission electron microscopy and UV-vis absorption spectroscopy. The results showed that the nucleation and growth of the nanodumbbells were governed by an oriented aggregation growth mechanism. It is noteworthy that the concentration of poly(vinyl pyrrolidone) and the volume ratio of H{sub 2}O to CH{sub 3}COOH were crucial to the growth of the final nanoarchitectures. Control experiments were also carried out to investigate the factors which impact on the morphology of the products. Furthermore, the as-prepared BiVO{sub 4} hierarchical nanostructures demonstrated the superior visible-light-driven photocatalytic efficiency, which is helpful for the separation and recycle considering their promising applications in harmful pollutants disposal. - Graphical Abstract: The controllable synthesis of novel dumbbell-like BiVO{sub 4} hierarchical nanostructures has been successfully obtained via a simple hydrothermal route; the as-prepared BiVO{sub 4} hierarchical nanostructures demonstrated the superior visible-light-driven photocatalytic efficiency. Highlights: Black-Right-Pointing-Pointer Dumbbell-like BiVO{sub 4} structures were synthesized and characterized for the first time. Black-Right-Pointing-Pointer The volume ratios of H{sub 2}O to CH{sub 3}COOH were crucial to the final morphologies. Black-Right-Pointing-Pointer Their photocatalytic activity was up to 90% under visible-light irradiation. Black-Right-Pointing-Pointer Dumbbell-like BiVO{sub 4} structures may utilize the pollutant disposal.
Forget, Anthony L.; Dombrowski, Christopher C.; Amitani, Ichiro; Kowalczykowski, Stephen C.
2015-01-01
In this Protocol, we describe a procedure to generate ‘DNA-dumbbells’ — single molecules of DNA with a microscopic bead attached at each end — and techniques for manipulating individual DNA-dumbbells. We also detail the design and fabrication of a microfluidic device (flow cell) used in conjunction with dual optical trapping to manipulate DNA-dumbbells and to visualize individual protein–DNA complexes by single-molecule epifluorescence microscopy. Our design of the flow cell enables the rapid movement of trapped molecules between laminar flow channels and a flow-free ‘reservoir’. The reservoir provides the means to examine formation of DNA–protein complexes in solution in the absence of external flow forces, while still maintaining a predetermined end-to-end extension of the DNA. These features facilitate examination of the role of three-dimensional DNA conformation and dynamics in protein–DNA interactions. Preparation of flow cells and reagents requires two days each; in situ DNA-dumbbell assembly and imaging of single protein–DNA complexes requires another day. PMID:23411634
NASA Astrophysics Data System (ADS)
Zhao, Shiqiang; Wei, Shanshan; Liu, Rui; Wang, Yuxi; Yu, Yue; Shen, Qiang
2015-06-01
Synthesis of materials with desirable nanostructures is a hot research topic owing to their enhanced performances in contrast to the bulk counterparts. Herein, dumbbell-shaped cobalt carbonate (CoCO3) nano architectures and the bulk counterpart of CoCO3 rhombohedra are prepared via a facile hydrothermal route in the presence and absence of ascorbic acid (AA), respectively. By comparison, it has been found that: the addition of AA in the hydrothermal crystallization system changes the shape of the building blocks from Co2CO3(OH)2 nanosheets to CoCO3 nanoparticles, and then further influences the final configuration of the products. When applied as anodes of lithium ion batteries, CoCO3 dumbbells deliver a 100th capacity of 1042 mAh g-1 at 200 mA g-1 and even exhibit a long-term value of 824 mAh g-1 over 500 cycles at 1000 mA g-1, which are much higher than the rhombohedral counterparts with corresponding 540 and 481 mAh g-1 respectively. The much higher capacity, better cycling stability and enhanced rate performance of CoCO3 dumbbells can be attributed to the higher specific surface area, smaller charge transport resistance and better structure stability resulting from the slight doping (∼4.6 wt%) of AA, and also relate with a novel lithium storage mechanism in CoCO3.
Takayuki, Hashimoto; Yamane, Hisanori; Becker, Nils; Dronskowski, Richard
2015-10-15
Black, metallic luster, platelet single crystals of Ba{sub 26}B{sub 12}Si{sub 5}N{sub 27} were grown on a BN crucible wall by slowly cooling from 900 °C to 27 °C. X-ray diffraction analysis revealed that Ba{sub 26}B{sub 12}Si{sub 5}N{sub 27} crystallizes in an orthorhombic cell (a=17.6942(4) Å, b=34.1437(6) Å, c=10.0410(2) Å; space group Fdd2). Isolated nitridoborate anionic groups [BN{sub 2}]{sup 3–}, dumbbell-type Zintl polyanions [Si{sub 2}]{sup 2.8–}, and nitride anions N{sup 3–} are included in the structure. The structural formula is represented as (Ba{sup 2+}){sub 26}([BN{sub 2}]{sup 3–}){sub 12}[([Si{sub 2}]{sup 2.8–}){sub 1.25}(N{sup 3–}){sub 2×0.75}]{sub 2}. The [Si{sub 2}]{sup 2.8–} dumbbell with a Si–Si length of 2.177(5) Å has a bond order of 2.6, which is close to the triple bond of Si. - Graphical abstract: Single crystals of Ba{sub 26}B{sub 12}Si{sub 5}N{sub 27} grown by slow cooling from 900 °C have an orthorhombic crystal structure with space group Fdd2, containing nitridoborate anionic groups [BN{sub 2}]{sup 3–}, dumbbell-type Zintl polyanions [Si{sub 2}]{sup 2.8–}, and nitride anions N{sup 3–}. - Highlights: • A novel compound, Ba{sub 26}B{sub 12}Si{sub 5}N{sub 27}, was synthesized by slow cooling from 900 °C. • Single crystal X-ray diffraction clarified a new crystal structure. • Anionic groups [BN{sub 2}]{sup 3–} and dumbbell-type Zintl polyanions [Si{sub 2}]{sup 2.8–} are contained. • The [Si{sub 2}]{sup 2.8–} dumbbell has a bond order of 2.6, which is close to the triple bond.
Exchange bias effect in Au-Fe3O4 dumbbell nanoparticles induced by the charge transfer from gold
Feygenson, Mikhail; Bauer, John C.; Gai, Zheng; Marques, Carlos; Aronson, Meigan C.; Teng, Xiaowei; Su, Dong; Stanic, Vesna; Urban, Volker S.; Beyer, Kevin A.; Dai, Sheng
2015-08-10
We have studied the origin of the exchange bias effect in the Au-Fe3O4 dumbbell nanoparticles in two samples with different sizes of the Au seed nanoparticles (4.1 and 2.7 nm) and same size of Fe3O4 nanoparticles (9.8 nm). The magnetization, small-angle neutron-scattering, synchrotron x-ray diffraction, and scanning transmission electron microscope measurements determined the antiferromagnetic FeO wustite phase within Fe3O4 nanoparticles, originating at the interface with the Au nanoparticles. The interface between antiferromagnetic FeO and ferrimagnetic Fe3O4 is giving rise to the exchange bias effect. The strength of the exchange bias fields depends on the interfacial area and lattice mismatch between both phases. We propose that the charge transfer from the Au nanoparticles is responsible for a partial reduction of the Fe3O4 into the FeO phase at the interface with Au nanoparticles. The Au-O bonds are formed, presumably across the interface to accommodate an excess of oxygen released during the reduction of magnetite
Exchange bias effect in Au-Fe3O4 dumbbell nanoparticles induced by the charge transfer from gold
Feygenson, Mikhail; Bauer, John C; Gai, Zheng; ...
2015-08-10
We have studied the origin of the exchange bias effect in the Au-Fe3O4 dumbbell nanoparticles in two samples with different sizes of the Au seed nanoparticles (4.1 and 2.7 nm) and same size of Fe3O4 nanoparticles (9.8 nm). The magnetization, small-angle neutron scattering, synchrotron x-ray diffraction and scanning transmission electron microscope measurements determined the antiferromagnetic FeO wüstite phase within Fe3O4 nanoparticles, originating at the interface with the Au nanoparticles. The interface between antiferromagnetic FeO and ferrimagnetic Fe3O4 is giving rise to the exchange bias effect. The strength of the exchange bias fields depends on the interfacial area and lattice mismatchmore » between both phases. We propose that the charge transfer from the Au nanoparticles is responsible for a partial reduction of the Fe3O4 into FeO phase at the interface with Au nanoparticles. The Au-O bonds are formed across the interface to accommodate an excess of oxygen released during the reduction of magnetite.« less
NASA Astrophysics Data System (ADS)
Bourhill, J.; Ivanov, E.; Tobar, M. E.
2015-08-01
We present first results from a number of experiments conducted on a 0.53-kg cylindrical dumbbell-shaped sapphire crystal. Here we report on an optomechanical experiment utilizing a modification to the typical cylindrical architecture. Mechanical motion of the crystal structure alters the dimensions of the crystal, and the induced strain changes the permittivity. These two effects result in parametric frequency modulation of resonant microwave whispering gallery modes that are simultaneously excited within the crystal. A microwave readout system is implemented, allowing extremely low noise measurements of this frequency modulation near our modes of interest, having a phase noise floor of -165 dBc/Hz at 100 kHz. Fine tuning of the crystal's suspension has allowed for the optimization of mechanical quality factors in preparation for cryogenic experiments, with a value of Q =8 ×107 achieved at 127 kHz. This results in a Q ×f product of 1013, equivalent to the best measured values in a macroscopic sapphire mechanical system. Results are presented that demonstrate the excitation of mechanical modes via radiation pressure force, allowing an experimental method of determining the transducer's displacement sensitivity d f /d x and calibrating the system. Finally, we demonstrate parametric backaction phenomenon within the system. These are all important steps towards the goal of achieving quantum limited measurements of a kilogram-scale macroscopic device for the purpose of detecting deviations from standard quantum theory resulting from quantum gravitational effects.
Synthesis of gold nano-wire and nano-dumbbell shaped colloids and AuC60 nano-clusters
NASA Astrophysics Data System (ADS)
Landon, Preston B.; Jarvis, Brandon C.; Gilleland, Cody L.; Renfro, Tim; Gutierrez, Jose; Synowczynski, Jennifer; Hirsch, Samuel G.; Glosser, Robert
2005-08-01
A technique for the fabrication of colloidal gold nano-wire and nano-dumbbell shaped particles using carbon nanotubes and rod shaped viruses as templates is described. The gold (Au) encapsulation process was accomplished by the precipitation of gold chloride from aqueous solutions. When this process was conducted in the presence of hydroxylated C60, small pieces of phase-separated composites of AuC60 appeared to have formed. These nano-clusters may turn out to be large noble metal analogs of the alkali metal fullerides with the smallest geometrically possible Au aggregate consisting of 55 gold atoms. The existence of noble metal fullerene composites has been previously theorized. The alkali metal fullerides are examples of phase separated solids and have exhibited superconductivity with temperatures as high 33K. The mechanism required for the binding energy between C60 and gold has been observed to exist between C60 and many of the mirror metals (Al, Ag, Au, Cu, Ni). This binding energy is a charge transfer from the metal Fermi level into the C60 LUMO. If this bonding energy, is greater than the metals coagulation energy an Au/C60 size terminated mechanism during the formation of the gold aggregates by the adhesion of C60 to the surface is energetically favorable.
Chen, Xuexu; Lin, Chunshui; Chen, Yiying; Wang, Yiru; Chen, Xi
2016-03-15
In this work we developed a novel label-free fluorescence sensing approach for the detection of nicotinamide adenine dinucleotide (NAD(+)) based on a dumbbell-like DNA probe designed for both ligation reaction and digestion reaction with low background noise. SYBR Green I (SG I), a double-helix dye, was chosen as the readout fluorescence signal. In the absence of NAD(+), the ligation reaction did not occur, but the probe was digested to mononucleotides after the addition of exonuclease I (Exo I) and exonuclease I (Exo III), resulting in a weak fluorescence intensity due to the weak interaction between SG I and mononucleotides. In the presence of NAD(+), the DNA probe was ligated by Escherichia coli DNA ligase, blocking the digestion by Exo I and Exo III. As a result, SG I was intercalated into the stem part of the DNA dumbbell probe and fluorescence enhancement was achieved. This method was simple in design, fast to operate, with good sensitivity and selectivity which could discriminate NAD(+) from its analogs.
De Cerchio, Leonardo; Contratti, Filiberto; Fraioli, Mario F
2006-10-01
The schwannomas are benign tumors originating from Schwann cells which constitute the nerve sheath. The dorsal pigmented type of schwannomas is relatively rare (Goldstein in Am J Med Genet 86:62-65, 2004; Kurtkaya-Yapicier in Histol Histopathol 18(3):925-934, 2003). There are two distinct types of melanotic schwannoma: the sporadic melanotic schwannomas and the psammomatous melanotic schwannomas of Carney complex. We report a case of a patient harboring a right dorsal dumb-bell melanotic schwannoma and left adrenal mass. The patient underwent a surgical procedure for en bloc total removal of the mass by a posterior and anterior approach. Histopathological examination revealed the diagnosis of melanotic schwannoma. At present, we have no reliable marker of histopathological malignancy of melanotic schwannoma so the follow-up period ought to continue for a period of more than 5 years. As the total removal of the melanotic neurinomas is mandatory to prevent possible malignant transformation of the tumor recurrence or regrowth, we believe that the posterior and trans-thoracic approach are the most suitable one for the dorsal dumb-bell schwannoma.
NASA Astrophysics Data System (ADS)
Heng, Ri-Liang; Pilon, Laurent
2016-05-01
This study presents experimental measurements of the radiation characteristics of unicellular freshwater cyanobacterium Synechocystis sp. during their exponential growth in F medium. Their scattering phase function at 633 nm average spectral absorption and scattering cross-sections between 400 and 750 nm were measured. In addition, an inverse method was used for retrieving the spectral effective complex index of refraction of overlapping or touching bispheres and quadspheres from their absorption and scattering cross-sections. The inverse method combines a genetic algorithm and a forward model based on Lorenz-Mie theory, treating bispheres and quadspheres as projected area and volume-equivalent coated spheres. The inverse method was successfully validated with numerically predicted average absorption and scattering cross-sections of suspensions consisting of bispheres and quadspheres, with realistic size distributions, using the T-matrix method. It was able to retrieve the monomers' complex index of refraction with size parameter up to 11, relative refraction index less than 1.3, and absorption index less than 0.1. Then, the inverse method was applied to retrieve the effective spectral complex index of refraction of Synechocystis sp. approximated as randomly oriented aggregates consisting of two overlapping homogeneous spheres. Both the measured absorption cross-section and the retrieved absorption index featured peaks at 435 and 676 nm corresponding to chlorophyll a, a peak at 625 nm corresponding to phycocyanin, and a shoulder around 485 nm corresponding to carotenoids. These results can be used to optimize and control light transfer in photobioreactors. The inverse method and the equivalent coated sphere model could be applied to other optically soft particles of similar morphologies.
NASA Astrophysics Data System (ADS)
Lu, Yang; Luo, Yong-Song; Kong, De-Zhi; Zhang, De-Yang; Jia, Yong-Lei; Zhang, Xin-Wei
2012-02-01
The controllable synthesis of novel dumbbell-like BiVO4 hierarchical nanostructures has been successfully obtained via a simple hydrothermal route. The as-synthesized products were studied by X-ray powder diffraction, scanning electron microscopy, transmission electron microscopy and UV-vis absorption spectroscopy. The results showed that the nucleation and growth of the nanodumbbells were governed by an oriented aggregation growth mechanism. It is noteworthy that the concentration of poly(vinyl pyrrolidone) and the volume ratio of H2O to CH3COOH were crucial to the growth of the final nanoarchitectures. Control experiments were also carried out to investigate the factors which impact on the morphology of the products. Furthermore, the as-prepared BiVO4 hierarchical nanostructures demonstrated the superior visible-light-driven photocatalytic efficiency, which is helpful for the separation and recycle considering their promising applications in harmful pollutants disposal.
3D modelling of squeeze flow of unidirectional and fabric composite inserts
NASA Astrophysics Data System (ADS)
Ghnatios, Chady; Abisset-Chavanne, Emmanuelle; Chinesta, Francisco; Keunings, Roland
2016-10-01
The enhanced design flexibility provided to the thermo-forming of thermoplastic materials arises from the use of both continuous and discontinuous thermoplastic prepregs. Discontinuous prepregs are patches used to locally strengthen the part. In this paper, we propose a new modelling approach for suspensions involving composite patches that uses theoretical concepts related to discontinuous fibres suspensions, transversally isotropic fluids and extended dumbbell models.
Wu, Dan; Guo, Zhankui; Liu, Yixin; Guo, Aiping; Lou, Wanruo; Fan, Dawei; Wei, Qin
2015-03-01
A novel and sensitive nonenzymatic sandwich-type electrochemical immunosensor for the detection of gastric cancer biomarker CA72-4 was fabricated using dumbbell-like PtPd-Fe3O4 nanoparticles (NPs) as a novel kind of label. The signal amplification strategy, using the synergetic effect present in PtPd-Fe3O4 to increase the reduction ability of the NPs toward H2O2, improved the sensitivity of the immunosensor. The immunosensor was constructed by modifying glassy carbon electrode with reduced graphene oxide-tetraethylene pentamine (rGO-TEPA) for effective immobilization of primary anti-CA72-4 antibody (Ab1). Secondary anti-CA72-4 antibody (Ab2) was adsorbed onto the PtPd-Fe3O4 NPs. The proposed immunosensor displayed a wide linear range (0.001-10 U/mL) with the low detection limit (0.0003 U/mL). The immunosensor was evaluated for serum samples, receiving satisfactory results. Therefore, the immunosensor possesses excellent clinical value in cancer screening as well as convenient point-of-care diagnostics.
Chen, Jinyang; Ji, Xinghu; Tinnefeld, Philip; He, Zhike
2016-01-27
In this work, a multifunctional template for selective formation of fluorescent silver nanoclusters (AgNCs) or copper nanoparticles (CuNPs) is put forward. This dumbbell-shaped (DS) DNA template is made up of two cytosine hairpin loops and an adenine-thymine-rich double-helical stem which is closed by the loops. The cytosine loops act as specific regions for the growth of AgNCs, and the double-helical stem serves as template for the CuNPs formation. By carefully investigating the sequence and length of DS DNA, we present the optimal design of the template. Benefiting from the smart design and facile synthesis, a simple, label-free, and ultrasensitive fluorescence strategy for adenosine triphosphate (ATP) detection is proposed. Through the systematic comparison, it is found that the strategy based on CuNPs formation is more sensitive for ATP assay than that based on AgNCs synthesis, and the detection limitation was found to be 81 pM. What's more, the CuNPs formation-based method is successfully applied in the detection of ATP in human serum as well as the determination of cellular ATP. In addition to small target molecule, the sensing strategy was also extended to the detection of biomacromolecule (DNA), which illustrates the generality of this biosensor.
Feygenson, Mikhail; Bauer, John C; Gai, Zheng; Marques, Carlos; Aronson, Meigan C.; Teng, Xiaowei; Su, Dong; Stanic, Vesna; Urban, Volker S; Kevin, Beyer; Dai, Sheng
2015-08-10
We have studied the origin of the exchange bias effect in the Au-Fe_{3}O_{4} dumbbell nanoparticles in two samples with different sizes of the Au seed nanoparticles (4.1 and 2.7 nm) and same size of Fe_{3}O_{4} nanoparticles (9.8 nm). The magnetization, small-angle neutron scattering, synchrotron x-ray diffraction and scanning transmission electron microscope measurements determined the antiferromagnetic FeO wüstite phase within Fe_{3}O_{4} nanoparticles, originating at the interface with the Au nanoparticles. The interface between antiferromagnetic FeO and ferrimagnetic Fe_{3}O_{4} is giving rise to the exchange bias effect. The strength of the exchange bias fields depends on the interfacial area and lattice mismatch between both phases. We propose that the charge transfer from the Au nanoparticles is responsible for a partial reduction of the Fe_{3}O_{4} into FeO phase at the interface with Au nanoparticles. The Au-O bonds are formed across the interface to accommodate an excess of oxygen released during the reduction of magnetite.
Kawai, Nobuyuki Sato, Morio Minamiguchi, Hiroyuki Nakai, Tomoki Ikoma, Akira Sawa, Munehisa Sahara, Shinya Nakata, Kouhei Tanaka, Takami Takasaka, Isao Sonomura, Tetsuo
2011-12-15
A 60-year-old woman presented with a conglomerate pulmonary arteriovenous malformation (PAVM) size 8.2 Multiplication-Sign 7.2 cm on chest X-ray. Feeding arteries were A{sub a}{sup 7} and A{sub b}{sup 7}, A{sup 8}, and A{sup 10}. The diameter and length of the A{sub b}{sup 7} neck were 15.5 and 16 mm, respectively. After percutaneous transcatheter embolization of A{sup 8} and A{sup 10}, PTE of A{sub a}{sup 7} and A{sub b}{sup 7} was conducted under balloon occlusion with interlocking detachable coils using a technique of dumbbell-shaped framing and filling, making a bridge from A{sub b}{sup 7} to the trunk of A{sup 9} and A{sup 10}across A{sup 7}. Follow-up computed tomography 10 months after treatment showed marked shrinkage of the PAVM.
NASA Astrophysics Data System (ADS)
Mbarki, Mohammed; Touzani, Rachid St.; Rehorn, Christian W. G.; Gladisch, Fabian C.; Fokwa, Boniface P. T.
2016-10-01
The new ternary transition metal-rich borides Ta2OsB2 and TaRuB have been successfully synthesized by arc-melting the elements in a water-cooled crucible under an argon atmosphere. The crystal structures of both compounds were solved by single-crystal X-ray diffraction and their metal compositions were confirmed by EDX analysis. It was found that Ta2OsB2 and TaRuB crystallize in the tetragonal Nb2OsB2 (space group P4/mnc, no. 128) and the orthorhombic NbRuB (space group Pmma, no. 51) structure types with lattice parameters a=5.878(2) Å, c=6.857(2) Å and a=10.806(2) Å, b=3.196(1) Å, c=6.312(2) Å, respectively. Furthermore, crystallographic, electronic and bonding characteristics have been studied by density functional theory (DFT). Electronic structure relaxation has confirmed the crystallographic parameters while COHP bonding analysis indicates that B2-dummbells are the strongest bonds in both compounds. Moreover, the formation of osmium dumbbells in Ta2OsB2 through a Peierls distortion along the c-axis, is found to be the origin of superstructure formation. Magnetic susceptibility measurements reveal that the two phases are Pauli paramagnets, thus confirming the theoretical DOS prediction of metallic character. Also hints of superconductivity are found in the two phases, however lack of single phase samples has prevented confirmation. Furthermore, the thermodynamic stability of the two modifications of AMB (A=Nb, Ta; M =Ru, Os) are studied using DFT, as new possible phases containing either B4- or B2-units are predicted, the former being the most thermodynamically stable modification.
A model of hydrodynamic interaction between swimming bacteria.
Gyrya, V.; Aranson, I. G.; Berlyand, L. V.; Karpeev, D.; Penn State Univ.
2010-01-01
We study the dynamics and interaction of two swimming bacteria, modeled by self-propelled dumbbell-type structures. We focus on alignment dynamics of a coplanar pair of elongated swimmers, which propel themselves either by 'pushing' or 'pulling' both in three- and quasi-two-dimensional geometries of space. We derive asymptotic expressions for the dynamics of the pair, which complemented by numerical experiments, indicate that the tendency of bacteria to swim in or swim off depends strongly on the position of the propulsion force. In particular, we observe that positioning of the effective propulsion force inside the dumbbell results in qualitative agreement with the dynamics observed in experiments, such as mutual alignment of converging bacteria.
NASA Astrophysics Data System (ADS)
Chantawansri, T. L.; Sliozberg, Y. R.; Hsieh, A.; Andzelm, J. W.
2012-02-01
Microphase-separated PUU, which consists of 4,4'-dicyclohexylmethane diisocyanate, diethyltoluenediamine and poly[tetramethylene oxide](PTMO), exhibits versatile mechanical properties making them an excellent choice for potential applications in the form of films, adhesives, coatings and matrix materials for composites. To elucidate the effects of composition, including the hard segment content & molecular weight of PTMO, on rate-dependent mechanical deformation in the high strain-rate regime (>> 10^5/s) the stress-strain behavior for PUU at various rates are calculated for four model systems using a coarse-grain model. Pair interactions between topologically non-connected particles are described by the standard truncated Lennard-Jones (LJ) pair potential, where bonded particles interact according to the standard FENE/LJ potential. An angle harmonic potential is also used to enforce the rigidity of the hard segments, and the system is evolved using molecular dynamics. Stress-strain curves are calculated at various strain-rates and qualitatively agree with experimental results when extrapolated to higher rate. Further analysis of the morphology is also performed to characterize the morphology and discern its connection to the calculated mechanical properties.
Capillary thinning and breakup of saliva threads and rheological aging of mucin solutions
NASA Astrophysics Data System (ADS)
Wagner, Caroline; Bourouiba, Lydia; McKinley, Gareth
2014-11-01
The elasticity of saliva, which is essential for many of its primary functions such as lubrication, arises largely as a result of the presence of MUC5B mucins. These are large glycoproteins composed of numerous repeated polymeric subunits forming a weakly crosslinked network. It has been noted for nearly a century that once removed from the mouth, saliva quickly loses its elasticity, which can be quantified by a decrease in its capillary breakup time. We model saliva as a dilute finitely extensible nonlinear elastic (FENE-P) fluid with polymer chains composed of dispersed Hookean dumbbells of maximum extensibility b related to the number of MUC5B subunits. We show that under conditions of simple elongational flow, an analytic prediction of the time evolution of the radius and the filament breakup time can be derived. Furthermore, our model shows that decreasing the maximum extensibility b leads to a decrease in the breakup time, which suggests that the aging process of saliva outside the mouth involves a shortening of the MUC5B mucin chains into smaller groupings. Finally, we compare the analytic breakup times from the model with experimental results obtained using a capillary breakup extensional rheometer and human whole saliva.
NASA Astrophysics Data System (ADS)
Ogungbemi, Kayode; Han, Xianming; Blosser, Micheal; Misra, Prabhakar; LASER Spectroscopy Group Collaboration
2014-03-01
Optogalvanic transitions have been recorded and fitted for 1s5 - 2p7\\ (621.7 nm), 1s5 - 2p8 (633.4 nm) and 1s5 - 2p9 (640.2 nm) transitions of neon in a Fe-Ne hollow cathode plasma discharge as a function of current (2-19 mA) and time evolution (0-50 microsec). The optogalvanic waveforms have been fitted to a Monte carlo mathematical model. The variation in the excited population of neon is governed by the rate of collision of the atoms involving the common metastable state (1s5) for the three transitions investigated. The concomitant changes in amplitudes and intensities of the optogalvanic signal waveforms associated with these transitions have been studied rigorously and the fitted parameters obtained using the Monte Carlo algorithm to help better understand the physics of the hollow cathode discharge. Thanks to Laser Spectroscopy group in Physics and Astronomy Dept. Howard University Washington DC.
NASA Astrophysics Data System (ADS)
Jiang, Jianwen; Blum, Lesser; Bernard, Oliver; Prausnitz, John M.; Sandler, Stanley I.
2002-05-01
Ion association is incorporated into the restricted-primitive model electrolyte to account for the strong attraction between unlike ions. Two methods are investigated within the McMillan-Mayer framework: first is the binding mean-spherical approximation (BIMSA) based on the Wertheim Ornstein-Zernike integral equation formalism; and the second is the combination of the BIMSA with a simple interpolation scheme based on the Wertheim thermodynamic perturbation theory. The latter gives a better description. Four different association constants are used to calculate the degree of dissociation, the critical point, and the vapor-liquid coexistence curve. An increase in the association constant leads to a lower critical temperature and a higher critical density, and better agreement with computer simulations. When unlike ions are fully paired, corresponding to a charged hard dumbbell system, we obtain the best agreement with the most recent computer simulations of the RPM electrolyte.
Jiang, Jianwen; Blum, Lesser; Bernard, Oliver; Prausnitz, John M.
2001-11-01
Ion association is incorporated into the restricted-primitive model (RPM) electrolyte to account for the strong attraction between unlike ions. Two methods are investigated within the McMillan-Mayer framework: first is the binding mean-spherical approximation (BIMSA) based on the Wertheim Ornstein-Zernike integral equation formalism; and the second is the combination of the BIMSA with a simple interpolation scheme (SIS) based on the Wertheim thermodynamic perturbation theory. The latter gives a better description. Four different association constants are used to calculate the degree of dissociation, the critical point and the vapor-liquid coexistence curve. An increase in the association constant leads to a lower critical temperature and a higher critical density, and better agreement with computer simulations. When unlike ions are fully paired, corresponding to a charged hard dumbbell (CHDB) system, we obtain the best agreement with the most recent computer simulations of the RPM electrolyte.
First-principles study of point defects in an fcc Fe-10Ni-20Cr model alloy
NASA Astrophysics Data System (ADS)
Piochaud, J. B.; Klaver, T. P. C.; Adjanor, G.; Olsson, P.; Domain, C.; Becquart, C. S.
2014-01-01
The influence of the local environment on vacancy and self-interstitial formation energies has been investigated in a face-centered-cubic (fcc) Fe-10Ni-20Cr model alloy by analyzing an extensive set of first-principle calculations based on density functional theory. Chemical disorder has been considered by designing special quasirandom structures and four different collinear magnetic structures have been investigated in order to determine a relevant reference state to perform point defect calculations at 0 K. Two different convergence methods have also been used to characterize the importance of the method on the results. Although our fcc Fe-10Ni-20Cr would be better represented in terms of applications by the paramagnetic state, we found that the antiferromagnetic single-layer magnetic structure was the most stable at 0 K and we chose it as a reference state to determine the point defect properties. Point defects have been introduced in this reference state, i.e., vacancies and Fe-Fe, Fe-Ni, Fe-Cr, Cr-Cr, Ni-Ni, and Ni-Cr dumbbell interstitials oriented either parallel or perpendicular to the single layer antiferromagnetic planes. Each point defect studied was introduced at different lattice sites to consider a sufficient variety of local environments and analyze its influence on the formation energy values. We have estimated the point defect formation energies with linear regressions using variables which describe the local environment surrounding the point defects. The number and the position of Ni and Cr first nearest neighbors to the point defects were found to drive the evolution of the formation energies. In particular, Ni is found to decrease and Cr to increase the vacancy formation energy of the model alloy, while the opposite trends are found for the dumbbell interstitials. This study suggested that, to a first approximation, the first nearest atoms to point defects can provide reliable estimates of point defect formation energies.
NASA Astrophysics Data System (ADS)
Ribeiro, V. A. R. M.; Bode, M. F.; Darnley, M. J.; Harman, D. J.; Newsam, A. M.; O'Brien, T. J.; Bohigas, J.; Echevarría, J. M.; Bond, H. E.; Chavushyan, V. H.; Costero, R.; Coziol, R.; Evans, A.; Eyres, S. P. S.; León-Tavares, J.; Richer, M. G.; Tovmassian, G.; Starrfield, S.; Zharikov, S. V.
2009-10-01
We report Hubble Space Telescope (HST) imaging, obtained 155 and 449 days after the 2006 outburst of the recurrent nova RS Ophiuchi, together with ground-based spectroscopic observations, obtained from the Observatorio Astronómico Nacional en San Pedro Mártir, Baja California, México and at the Observatorio Astrofísico Guillermo Haro, at Cananea, Sonora, México. The observations at the first epoch were used as inputs to model the geometry and kinematic structure of the evolving RS Oph nebular remnant. We find that the modeled remnant comprises two distinct co-aligned bipolar components; a low-velocity, high-density innermost (hour glass) region and a more extended, high-velocity (dumbbell) structure. This overall structure is in agreement with that deduced from radio observations and optical interferometry at earlier epochs. We find that the asymmetry observed in the west lobe is an instrumental effect caused by the profile of the HST filter and hence demonstrate that this lobe is approaching the observer. We then conclude that the system has an inclination to the line of sight of 39+1°-10. This is in agreement with the inclination of the binary orbit and lends support to the proposal that this morphology is due to the interaction of the outburst ejecta with either an accretion disk around the central white dwarf and/or a pre-existing red giant wind that is significantly denser in the equatorial regions of the binary than at the poles. The second epoch HST observation was also modeled. However, as no spectra were taken at this epoch, it is more difficult to constrain any model. Nevertheless, we demonstrate that between the two HST epochs the outer dumbbell structure seems to have expanded linearly. For the central (hour glass) region, there may be evidence of deceleration, but it is harder to draw firm conclusions in this case.
Modeling the Relaxation Time of DNA Confined in a Nanochannel
NASA Astrophysics Data System (ADS)
Wang, Yanwei; Tree, Douglas R.; Dorfman, Kevin D.
2014-03-01
Using a mapping between a dumbbell model and fine-grained Monte Carlo simulations, we have computed the relaxation time of λ-DNA in a high ionic strength buffer confined in a nanochannel (Tree et al., Biomicrofluidics 2013, 7, 054118). The relaxation time thus obtained agrees quantitatively with experimental data (Reisner et al., PRL 2005, 94, 196101) using only a single O(1) fitting parameter to account for the uncertainty in model parameters. In addition to validating our mapping, this agreement supports our previous estimates of the friction coefficient of DNA confined in a nanochannel (Tree et al., PRL 2012, 108, 228105), which have been difficult to validate due to the lack of direct experimental data. Furthermore, our calculation shows that as the channel size passes below ~100 nm (or roughly the Kuhn length of DNA) there is a dramatic drop in the relaxation time. Inasmuch as the chain friction rises with decreasing channel size, the reduction in the relaxation time can be solely attributed to the sharp decline in the fluctuations of the chain extension. Practically, the low variance in the observed DNA extension in such small channels has important implications for genome mapping. This work was supported by the NIH (R01-HG005216 and R01-HG006851) and the NSFC (21204061) and was carried out in part using computing resources at the University of Minnesota Supercomputing Institute.
Transport coefficient computation based on input/output reduced order models
NASA Astrophysics Data System (ADS)
Hurst, Joshua L.
equation. Its a recursive method that solves nonlinear ODE's by solving a LTV systems at each iteration to obtain a new closer solution. LTV models are derived for both Gosling and Lees-Edwards type models. Particular attention is given to SLLOD Lees-Edwards models because they are in a form most amenable to performing Taylor series expansion, and the most commonly used model to examine viscosity. With linear models developed a method is presented to calculate viscosity based on LTI Gosling models but is shown to have some limitations. To address these issues LTV SLLOD models are analyzed with both Balanced Truncation and POD and both show that significant order reduction is possible. By examining the singular values of both techniques it is shown that Balanced Truncation has a potential to offer greater reduction, which should be expected as it is based on the input/output mapping instead of just the state information as in POD. Obtaining reduced order systems that capture the property of interest is challenging. For Balanced Truncation reduced order models for 1-D LJ and FENE systems are obtained and are shown to capture the output of interest fairly well. However numerical challenges currently limit this analysis to small order systems. Suggestions are presented to extend this method to larger systems. In addition reduced 2nd order systems are obtained from POD. Here the challenge is extending the solution beyond the original period used for the projection, in particular identifying the manifold the solution travels along. The remaining challenges are presented and discussed.
NASA Astrophysics Data System (ADS)
Barrett, John W.; Süli, Endre
2016-07-01
We prove the existence of global-in-time weak solutions to a general class of models that arise from the kinetic theory of dilute solutions of nonhomogeneous polymeric liquids, where the polymer molecules are idealized as bead-spring chains with finitely extensible nonlinear elastic (FENE) type spring potentials. The class of models under consideration involves the unsteady, compressible, isentropic, isothermal Navier-Stokes system in a bounded domain Ω in Rd, d = 2, for the density ρ, the velocity u ˜ and the pressure p of the fluid, with an equation of state of the form p (ρ) =cpργ, where cp is a positive constant and γ > 1. The right-hand side of the Navier-Stokes momentum equation includes an elastic extra-stress tensor, which is the classical Kramers expression. The elastic extra-stress tensor stems from the random movement of the polymer chains and is defined through the associated probability density function that satisfies a Fokker-Planck-type parabolic equation, a crucial feature of which is the presence of a centre-of-mass diffusion term. This extends the result in our paper J.W. Barrett and E. Süli (2016) [9], which established the existence of global-in-time weak solutions to the system for d ∈ { 2 , 3 } and γ >3/2, but the elastic extra-stress tensor required there the addition of a quadratic interaction term to the classical Kramers expression to complete the compactness argument on which the proof was based. We show here that in the case of d = 2 and γ > 1 the existence of global-in-time weak solutions can be proved in the absence of the quadratic interaction term. Our results require no structural assumptions on the drag term in the Fokker-Planck equation; in particular, the drag term need not be corotational. With a nonnegative initial density ρ0 ∈L∞ (Ω) for the continuity equation; a square-integrable initial velocity datum u˜0 for the Navier-Stokes momentum equation; and a nonnegative initial probability density function ψ0
Structural model of the cytosolic domain of the plant ethylene receptor 1 (ETR1).
Mayerhofer, Hubert; Panneerselvam, Saravanan; Kaljunen, Heidi; Tuukkanen, Anne; Mertens, Haydyn D T; Mueller-Dieckmann, Jochen
2015-01-30
Ethylene initiates important aspects of plant growth and development through disulfide-linked receptor dimers located in the endoplasmic reticulum. The receptors feature a small transmembrane, ethylene binding domain followed by a large cytosolic domain, which serves as a scaffold for the assembly of large molecular weight complexes of different ethylene receptors and other cellular participants of the ethylene signaling pathway. Here we report the crystallographic structures of the ethylene receptor 1 (ETR1) catalytic ATP-binding and the ethylene response sensor 1 dimerization histidine phosphotransfer (DHp) domains and the solution structure of the entire cytosolic domain of ETR1, all from Arabidopsis thaliana. The isolated dimeric ethylene response sensor 1 DHp domain is asymmetric, the result of different helical bending angles close to the conserved His residue. The structures of the catalytic ATP-binding, DHp, and receiver domains of ethylene receptors and of a homologous, but dissimilar, GAF domain were refined against experimental small angle x-ray scattering data, leading to a structural model of the entire cytosolic domain of the ethylene receptor 1. The model illustrates that the cytosolic domain is shaped like a dumbbell and that the receiver domain is flexible and assumes a position different from those observed in prokaryotic histidine kinases. Furthermore the cytosolic domain of ETR1 plays a key role, interacting with all other receptors and several participants of the ethylene signaling pathway. Our model, therefore, provides the first step toward a detailed understanding of the molecular mechanics of this important signal transduction process in plants.
NASA Astrophysics Data System (ADS)
Fang, Lin
The goal of our research is to optically visualize shear-induced polymer migration near a surface on the single molecular level, and to enhance current understanding of interactions between flowing polymer solutions with surfaces. By using epi-fluorescence microscopy, we measured the mean fractional stretch and concentrations of lambda-phage DNA molecules above a glass surface in shear flows in a microchannel and a torsional shear cell. We find that DNA molecules are driven away to create a depletion layer near the surface. The shear-induced migration is enhanced with a larger depletion layer at high Weissenberg number (Wi), in qualitative agreement with theories. We proposed a simple mechanism for this shear-induced migration based on hydrodynamic interaction (HI) between the surface and polymer chains. We find that the thickness of depletion layer of lambda-phage DNA molecules is about 10mum at Wi = 10.3, which is thinner than in the predictions for the FENE-P dumbbell model [Ma and Graham (2005)] and in Brownian dynamics simulations. The discrepancies suggest that current theoretical models of the polymer migration phenomenon are incomplete. We find that the time scale of DNA migration is on the order of the diffusion time over the distance of depletion layer, and that the mean fractional stretch of DNA molecules decreases near the surface over this same time scale. Experiments with deliberately fragmented DNA indicate that the decrease in mean fractional stretch near the surface might be caused by the selective retention of fragments in the DNA solution owing to weaker HI effects between the surface and shorter polymer chains. The shear-induced migration of DNA molecules exists in diminished form up to 3.0 c* (c* is the overlap concentration), implying that: in the traditionally defined dilute regime (c < c*), screening of wall hydrodynamics occurs over DNA concentration from 0.1 c* to 1.0 c*; and in the semidilute regime (c > c*); while the chains are
Dane Morgan
2010-06-10
The project began March 13, 2006, allocated for three years, and received a one year extension from March 13, 2009 to March 12, 2010. It has now completed 48 of 48 total months. The project was focused on using ab initio methods to gain insights into radiation induced segregation (RIS) in Ni-Fe-Cr alloys. The project had the following key accomplishments • Development of a large database of ab initio energetics that can be used by many researchers in the future for increased understanding of this system. For example, we have the first calculations showing a dramatic stabilization effect of Cr-Cr interstitial dumbbells in Ni. • Prediction of both vacancy and interstitial diffusion constants for Ni-Cr and Ni-Fe for dilute Cr and Fe. This work included generalization of widely used multifrequency models to make use of ab initio derived energetics and thermodynamics. • Prediction of qualitative trends of RIS from vacancy and interstitial mechanisms, suggesting the two types of defect fluxes drive Cr RIS in opposite directions. • Detailed kinetic Monte Carlo modeling of diffusion by vacancy mechanism in Ni-Cr as a function of Cr concentration. The results demonstrate that Cr content can have a significant effect on RIS. • Development of a quantitative RIS transport model, including models for thermodynamic factors and boundary conditions.
A new generic model potential for mesogenic systems: square well line potential of variable range.
Varga, Szabolcs; Vesely, Franz J
2009-11-21
A single-site pair potential is derived to approximate the linear n-site square well interaction. The resulting square well line (SWL) potential is analytical, fairly smooth, and reproduces the distance and orientation dependence of the multisite pair energy. It contains only three control parameters n, L, and s(2), in addition to the units of length s(1) and energy epsilon. The advantages of the new model over the traditional potentials such as Gay-Berne and Kihara are that n, L, and s(2) are physically meaningful quantities and that no additional adjustable parameters are introduced. With the SWL potential even very long square well chain molecules may be treated in Monte Carlo (MC) simulations; moreover the model is well suited for perturbation theory. Using Onsager-like theories we test the effect of molecular elongation, temperature, and the range of the square well potential on the vapor-liquid and nematic-smectic A (NS) phase transitions. We find that the vapor-liquid binodal of the SWL fluid is in good agreement with MC results for square well dumbbells. For repulsive SWL particles, varying the interaction range s(2) results in a similar effect on the NS transition as the change in the ionic strength in a real suspension of fd viruses.
The impact of bonded interactions on the ground-state geometries of a small flexible polymer
NASA Astrophysics Data System (ADS)
Koci, Tomas; Qi, Kai; Bachmann, Michael
2016-10-01
Bonded interactions in coarse-grained models of elastic polymers are commonly represented by the finitely extensible nonlinear elastic (FENE) potential. In this study, we perform parallel multicanonical Monte Carlo simulations to examine the impact of an additional Lennard-Jones term in the bonded potential on the geometry of ground-state structures of a short polymer. Employing microcanonical inflection point analysis and conformational analysis, we construct a hyper-phase diagram and identify ground-state structures with two distinct geometries.
Wright, Harrison; van Doorn, Wouter G; Gunawardena, Arunika H L A N
2009-05-01
Programmed cell death (PCD) is required for many morphological changes, but in plants it has been studied in much less detail than in animals. The unique structure and physiology of the lace plant (Aponogeton madagascariensis) is well suited for the in vivo study of developmental PCD. Live streaming video and quantitative analysis, coupled with transmission electron microscopy, were used to better understand the PCD sequence, with an emphasis on the chloroplasts. Dividing, dumbbell-shaped chloroplasts persisted until the late stages of PCD. However, the average size and number of chloroplasts, and the starch granules associated with them, declined steadily in a manner reminiscent of leaf senescence, but distinct from PCD described in the Zinnia tracheary element system. Remaining chloroplasts often formed a ring around the nucleus. Transvacuolar strands, which appeared to be associated with chloroplast transport, first increased and then decreased. Mitochondrial streaming ceased abruptly during the late stages of PCD, apparently due to tonoplast rupture. This rupture occurred shortly before the rapid degradation of the nucleus and plasma membrane collapse, in a manner also reminiscent of the Zinnia model. The presence of numerous objects in the vacuoles suggests increased macro-autophagy before cell death. These objects were rarely observed in cells not undergoing PCD.
RECENT ADVANCES IN MACROMOLECULAR HYDRODYNAMIC MODELING
Aragon, Sergio R.
2010-01-01
The modern implementation of the boundary element method (S.R. Aragon, J. Comput. Chem. 25(2004)1191–12055) has ushered unprecedented accuracy and precision for the solution of the Stokes equations of hydrodynamics with stick boundary conditions. This article begins by reviewing computations with the program BEST of smooth surface objects such as ellipsoids, the dumbbell, and cylinders that demonstrate that the numerical solution of the integral equation formulation of hydrodynamics yields very high precision and accuracy. When BEST is used for macromolecular computations, the limiting factor becomes the definition of the molecular hydrodynamic surface and the implied effective solvation of the molecular surface. Studies on 49 different proteins, ranging in molecular weight from 9 to over 400 kDa, have shown that a model using a 1.1 A thick hydration layer describes all protein transport properties very well for the overwhelming majority of them. In addition, this data implies that the crystal structure is an excellent representation of the average solution structure for most of them. In order to investigate the origin of a handful of significant discrepancies in some multimeric proteins (over −20% observed in the intrinsic viscosity), the technique of Molecular Dynamics simulation (MD) has been incorporated into the research program. A preliminary study of dimeric α-chymotrypsin using approximate implicit water MD is presented. In addition I describe the successful validation of modern protein force fields, ff03 and ff99SB, for the accurate computation of solution structure in explicit water simulation by comparison of trajectory ensemble average computed transport properties with experimental measurements. This work includes small proteins such as lysozyme, ribonuclease and ubiquitin using trajectories around 10 ns duration. We have also studied a 150 kDa flexible monoclonal IgG antibody, trastuzumab, with multiple independent trajectories encompassing over
Analytic model for low energy excitation states and phase transitions in spin-ice systems
NASA Astrophysics Data System (ADS)
López-Bara, F. I.; López-Aguilar, F.
2017-04-01
Low energy excitation states in magnetic structures of the so-called spin-ices are produced via spin flips among contiguous tetrahedra of their crystal structure. These spin flips generate entities which mimic magnetic dipoles in every two tetrahedra according to the dumbbell model. When the temperature increases, the spin-flip processes are transmitted in the lattice, generating so-called Dirac strings, which constitute structural entities that can present mimetic behavior similar to that of magnetic monopoles. In recent studies of both specific heat and ac magnetic susceptibility, two (even possibly three) phases have been shown to vary the temperature. The first of these phases presents a sharp peak in the specific heat and another phase transition occurs for increasing temperature whose peak is broader than that of the former phase. The sharp peak occurs when there are no free individual magnetic charges and temperature of the second phase transition coincides with the maximum proliferation of free deconfined magnetic charges. In the present paper, we propose a model for analyzing the low energy excitation many-body states of these spin-ice systems. We give analytical formulas for the internal energy, specific heat, entropy and their temperature evolution. We study the description of the possible global states via the nature and structure of their one-body components by means of the thermodynamic functions. Below 0.37 K, the Coulomb-like magnetic charge interaction can generate a phase transition to a condensation of pole–antipole pairs, possibly having Bose–Einstein structure which is responsible for the sharp peak of the first phase transition. When there are sufficient free positive and negative charges, the system tends to behave as a magnetic plasma, which implies the broader peak in the specific heat appearing at higher temperature than the sharper experimental peak.
Structural characterization suggests models for monomeric and dimeric forms of full-length ezrin.
Phang, Juanita M; Harrop, Stephen J; Duff, Anthony P; Sokolova, Anna V; Crossett, Ben; Walsh, James C; Beckham, Simone A; Nguyen, Cuong D; Davies, Roberta B; Glöckner, Carina; Bromley, Elizabeth H C; Wilk, Krystyna E; Curmi, Paul M G
2016-09-15
Ezrin is a member of the ERM (ezrin-radixin-moesin) family of proteins that have been conserved through metazoan evolution. These proteins have dormant and active forms, where the latter links the actin cytoskeleton to membranes. ERM proteins have three domains: an N-terminal FERM [band Four-point-one (4.1) ERM] domain comprising three subdomains (F1, F2, and F3); a helical domain; and a C-terminal actin-binding domain. In the dormant form, FERM and C-terminal domains form a stable complex. We have determined crystal structures of the active FERM domain and the dormant FERM:C-terminal domain complex of human ezrin. We observe a bistable array of phenylalanine residues in the core of subdomain F3 that is mobile in the active form and locked in the dormant form. As subdomain F3 is pivotal in binding membrane proteins and phospholipids, these transitions may facilitate activation and signaling. Full-length ezrin forms stable monomers and dimers. We used small-angle X-ray scattering to determine the solution structures of these species. As expected, the monomer shows a globular domain with a protruding helical coiled coil. The dimer shows an elongated dumbbell structure that is twice as long as the monomer. By aligning ERM sequences spanning metazoan evolution, we show that the central helical region is conserved, preserving the heptad repeat. Using this, we have built a dimer model where each monomer forms half of an elongated antiparallel coiled coil with domain-swapped FERM:C-terminal domain complexes at each end. The model suggests that ERM dimers may bind to actin in a parallel fashion.
On the eigenvalues of a "dumb-bell with a thin handle"
NASA Astrophysics Data System (ADS)
Gadyl'shin, R. R.
2005-04-01
We consider the Neumann boundary-value problem of finding the small-parameter asymptotics of the eigenvalues and eigenfunctions for the Laplace operator in a singularly perturbed domain consisting of two bounded domains joined by a thin "handle". The small parameter is the diameter of the cross-section of the handle. We show that as the small parameter tends to zero these eigenvalues converge either to the eigenvalues corresponding to the domains joined or to the eigenvalues of the Dirichlet problem for the Sturm-Liouville operator on the segment to which the thin handle contracts. The main results of this paper are the complete power small-parameter asymptotics of the eigenvalues and the corresponding eigenfunctions and explicit formulae for the first terms of the asymptotics. We consider critical cases generated by the choice of the place where the thin "handle" is joined to the domains, as well as by the multiplicity of the eigenvalues corresponding to the domains joined.
Giant dumb-bell calculus complicating vesico-vaginal fistula - a case report.
Nnabugwu, Ii; Osakue, E
2011-07-01
A 34 year old, para 1(+0) woman was seen in February 2009. Her only confinement was 4 years earlier and was complicated by vesicovaginal fistula (VVF) due to prolonged obstructed labour. She had had 2 failed repairs of the VVF before presentation. About a month before the presentation, she started experiencing increasing perineal and suprapubic pain and the sensation of bearing down. A calculus was readily felt per vaginam and further evaluation revealed its extension into the urinary bladder incorporating nylon suture and vaginal tissues. The calculus was successfully excised by a combination of suprapubic and vaginal approaches. Public enlightenment should emphasize that the first attempt at VVF repair by an experienced surgeon in a proper surgical setting is the best chance for a successful outcome.
Dumb-bell in the heart: rare case of biatrial myxoma with mitral regurgitation.
Ananthanarayanan, Chandrasekaran; Bishnoi, Arvind Kumar; Ramani, Jayadip; Gandhi, Hemang
2016-10-01
Cardiac myxomas are rare intracardiac tumors, and the majority are benign myxomas involving the left atrium. We report a case of the very rare occurrence of biatrial myxoma associated with mitral regurgitation, which was successfully treated.
Smart Nanofibers Self-Assembled from Dumbbell-Shaped Rod Amphiphiles
2011-09-01
end-capped hexa -p-phenylene as a aromatic rod and oligo(ethylene oxide) dendrons according to previously reported similar methods and characterized...feature of 9-arylcarbazole derivatives revealing that there is a non-zero dihedral angle between the carbazole and hexa -p-phenylene unit. On the
Dumbbell-shaped intradiploic epidermoid cyst involving the dura mater and cerebellum.
Ichimura, Shinya; Hayashi, Toshiyuki; Yazaki, Takahito; Yoshida, Kazunari; Kawase, Takeshi
2008-02-01
A 55-year-old woman presented with an epidermoid cyst extending to the cerebellum manifesting as headaches and pain in the left eye. Magnetic resonance imaging showed an intradiploic part with ring enhancement and an intracerebellar part. Intraoperative inspection revealed erosion of the occipital bone and defective dura mater. The tumor was located both epidurally and subdurally and the cyst consisted of pearly white keratin. The tumor was totally removed and the patient was discharged with no neurological deficit. The intradiploic part of the tumor formed the body and the intracerebellar part was caused by inflammatory reaction, which resulted in the atypical enhancement of the intradiploic part.
Study of an orbiting tethered dumbbell system having positive orbital energy
NASA Technical Reports Server (NTRS)
Arnold, David A.
1988-01-01
For very long tethered systems the sum of the kinetic and potential energy can be positive. The system remains in a circular orbit as long as the masses remain vertically aligned. The system is unstable without constant control of the alignment. If the upper mass rotates forward in the direction of the orbital motion, the system escapes out of orbit. If the upper mass rotates backward, the system falls out of orbit and the lower mass impacts the body around which the system is orbiting.
Cystogram with dumbbell shaped urinary bladder in a sliding inguinal hernia.
Mahadevappa, Basant; Suresh, Sumanth Channapatna; Natarajan, K; Thomas, Joseph
2009-01-01
Sliding inguinal hernias present with various symptoms and these are usually direct inguinal hernias containing various abdominal viscera. Case reports and series have been published with various organs and rare organs being part of the hernia. Urinary bladder is a known content of sliding hernias. This case report emphasizes this aspect in a picturesque manner and the importance of radiological investigations for pre-surgical evaluation.
Waterlike features, liquid-crystal phase and self-assembly in Janus dumbbells
NASA Astrophysics Data System (ADS)
Bordin, José Rafael
2016-10-01
We explore the phase diagram of Janus nanoparticles using Molecular Dynamics simulations. Each monomer in the dimer has distinct characteristics. One type of monomer interacts by a Lennard Jones potential, while the other type interacts through a two length scale potential. Previous studies for the monomeric system using this specific two length scale potential do not indicate the presence of waterlike anomalies. However, our results show that the combination of two length scales potential and LJ potential in the Janus nanoparticle will lead to thermodynamic and dynamic anomalies. The self-assembly properties were also explored. We observe distinct kinds of self-assembled structures and a liquid-crystal phase. This result indicates that it is possible to create Janus nanoparticles with waterlike features using monomers without anomalous behavior. The anomalies and structures are explained with the two length scale potential characteristics.
Coupled flow-polymer dynamics via statistical field theory: Modeling and computation
Ceniceros, Hector D. Fredrickson, Glenn H. Mohler, George O.
2009-03-20
Field-theoretic models, which replace interactions between polymers with interactions between polymers and one or more conjugate fields, offer a systematic framework for coarse-graining of complex fluids systems. While this approach has been used successfully to investigate a wide range of polymer formulations at equilibrium, field-theoretic models often fail to accurately capture the non-equilibrium behavior of polymers, especially in the early stages of phase separation. Here the 'two-fluid' approach serves as a useful alternative, treating the motions of fluid components separately in order to incorporate asymmetries between polymer molecules. In this work we focus on the connection of these two theories, drawing upon the strengths of each of the approaches in order to couple polymer microstructure with the dynamics of the flow in a systematic way. For illustrative purposes we work with an inhomogeneous melt of elastic dumbbell polymers, though our methodology will apply more generally to a wide variety of inhomogeneous systems. First we derive the model, incorporating thermodynamic forces into a two-fluid model for the flow through the introduction of conjugate chemical potential and elastic strain fields for the polymer density and stress. The resulting equations are composed of a system of fourth order PDEs coupled with a non-linear, non-local optimization problem to determine the conjugate fields. The coupled system is severely stiff and with a high degree of computational complexity. Next, we overcome the formidable numerical challenges posed by the model by designing a robust semi-implicit method based on linear asymptotic behavior of the leading order terms at small scales, by exploiting the exponential structure of global (integral) operators, and by parallelizing the non-linear optimization problem. The semi-implicit method effectively removes the fourth order stability constraint associated with explicit methods and we observe only a first order time
The biomechanical modelling of non-ballistic skin wounding: blunt-force injury.
Whittle, Kelly; Kieser, Jules; Ichim, Ionut; Swain, Michael; Waddell, Neil; Livingstone, Vicki; Taylor, Michael
2008-01-01
Knowledge of the biomechanical dynamics of blunt force trauma is indispensable for forensic reconstruction of a wounding event. In this study, we describe and interpret wound features on a synthetic skin model under defined laboratory conditions. To simulate skin and the sub-dermal tissues we used open-celled polyurethane sponge (foam), covered by a silicone layer. A drop tube device with three tube lengths (300, 400, and 500 mm), each secured to a weighted steel scaffold and into which a round, 5-kg Federal dumbbell of length 180 mm and diameter 8 cm was placed delivered blows of known impact. To calculate energy and velocity at impact the experimental set-up was replicated using rigid-body dynamics and motion simulation software. We soaked each foam square in 500 mL water, until fully saturated, immediately before placing it beneath the drop tube. We then recorded and classified both external and internal lacerations. The association between external wounding rates and the explanatory variables sponge type, sponge thickness, and height were investigated using Poisson regression. Tears (lacerations) of the silicone skin layer resembled linear lacerations seen in the clinical literature and resulted from only 48.6% of impacts. Poisson regression showed there was no significant difference between the rate of external wounding for different sponge types (P = 0.294) or different drop heights (P = 0.276). Most impacts produced "internal wounds" or subsurface cavitation (96%). There were four internal "wound" types; Y-shape (53%), linear (25%), stellate (16%), and double crescent (6%). The two-way interaction height by sponge type was statistically significant in the analysis of variance model (P = 0.035). The other two-way interactions; height by thickness and sponge type by thickness, were also bordering on statistical significance (P = 0.061 and P = 0.071, respectively). The observation that external wounds were present for less than half of impacts only, but that
NASA Astrophysics Data System (ADS)
Ali, Nasir; Asghar, Zaheer
2014-09-01
We have investigated the peristaltic motion of a non-Newtonian fluid characterized by the finitely extendable nonlinear elastic-Peterlin (FENE-P) fluid model. A background for the development of the differential constitutive equation of this model has been provided. The flow analysis is carried out both for two-dimensional planar channel and axisymmetric tube. The governing equations have been simplified under the widely used assumptions of long wavelength and low Reynolds number in a frame of reference that moves with constant wave speed. An exact solution is obtained for the stream function and longitudinal pressure gradient with no slip condition. We have portrayed the effects of Deborah number and extensibility parameter on velocity profile, trapping phenomenon, and normal stress. It is observed that normal stress is an increasing function of Deborah number and extensibility parameter. As far as the velocity at the channel (tube) center is concerned, it decreases (increases) by increasing Deborah number (extensibility parameter). The non-Newtonian rheology also affect the size of trapped bolus in a sense that it decreases (increases) by increasing Deborah number (extensibility parameter). Further, it is observed through numerical integration that both Deborah number and extensibility parameter have opposite effects on pressure rise per wavelength and frictional forces at the wall. Moreover, it is shown that the results for the Newtonian model can be deduced as a special case of the FENE-P model
ten Cate, Jacob M
2015-01-01
Developing experimental models to understand dental caries has been the theme in our research group. Our first, the pH-cycling model, was developed to investigate the chemical reactions in enamel or dentine, which lead to dental caries. It aimed to leverage our understanding of the fluoride mode of action and was also utilized for the formulation of oral care products. In addition, we made use of intra-oral (in situ) models to study other features of the oral environment that drive the de/remineralization balance in individual patients. This model addressed basic questions, such as how enamel and dentine are affected by challenges in the oral cavity, as well as practical issues related to fluoride toothpaste efficacy. The observation that perhaps fluoride is not sufficiently potent to reduce dental caries in the present-day society triggered us to expand our knowledge in the bacterial aetiology of dental caries. For this we developed the Amsterdam Active Attachment biofilm model. Different from studies on planktonic ('single') bacteria, this biofilm model captures bacteria in a habitat similar to dental plaque. With data from the combination of these models, it should be possible to study separate processes which together may lead to dental caries. Also products and novel agents could be evaluated that interfere with either of the processes. Having these separate models in place, a suggestion is made to design computer models to encompass the available information. Models but also role models are of the utmost importance in bringing and guiding research and researchers.
Hasan, Roumina; Kumar, Sandeep; Rao, Lakshmi
2013-01-01
Pelvic localization of synovial sarcoma is a rare phenomenon and to the best of our knowledge its presentation as a large "dumb-bell"-shaped abdomino-pelvic mass showing extension to the thigh has never been reported in the literature. We report a case of a young adult presenting with retention of urine and was found to have a large abdomino-pelvic mass causing bony destruction and compression of pelvic viscera. A biopsy revealed a cellular tumor composed of spindle to oval cells arranged in a hemangiopericytomatous pattern. Histopathology was suggestive of poorly differentiated synovial sarcoma. Immunohistochemistry (IHC) was positive for vimentin, CD 99, Bcl2, Mic2 and focally for EMA and negative for CD 34, CK, desmin, synaptophysin, and WT1. Due to equivocal IHC findings molecular analysis was done which confirmed the diagnosis as synovial sarcoma.
Nonlinear dynamic vibration absorbers with a saturation
NASA Astrophysics Data System (ADS)
Febbo, M.; Machado, S. P.
2013-03-01
The behavior of a new type of nonlinear dynamic vibration absorber is studied. A distinctive characteristic of the proposed absorber is the impossibility to extend the system to infinity. The mathematical formulation is based on a finite extensibility nonlinear elastic potential to model the saturable nonlinearity. The absorber is attached to a single degree-of-freedom linear/nonlinear oscillator subjected to a periodic external excitation. In order to solve the equations of motion and to analyze the frequency-response curves, the method of averaging is used. The performance of the FENE absorber is evaluated considering a variation of the nonlinearity of the primary system, the damping and the linearized frequency of the absorber and the mass ratio. The numerical results show that the proposed absorber has a very good efficiency when the nonlinearity of the primary system increases. When compared with a cubic nonlinear absorber, for a large nonlinearity of the primary system, the FENE absorber shows a better effectiveness for the whole studied frequency range. A complete absence of quasi-periodic oscillations is also found for an appropriate selection of the parameters of the absorber. Finally, direct integrations of the equations of motion are performed to verify the accuracy of the proposed method.
Models, Fiction, and Fictional Models
NASA Astrophysics Data System (ADS)
Liu, Chuang
2014-03-01
The following sections are included: * Introduction * Why Most Models in Science Are Not Fictional * Typically Fictional Models in Science * Modeling the Unobservable * Fictional Models for the Unobservable? * References
Mental Models, Conceptual Models, and Modelling.
ERIC Educational Resources Information Center
Greca, Ileana Maria; Moreira, Marco Antonio
2000-01-01
Reviews science education research into representations constructed by students in their interactions with the world, its phenomena, and artefacts. Features discussions of mental models, conceptual models, and the activity of modeling. (Contains 30 references.) (Author/WRM)
NASA Astrophysics Data System (ADS)
Dubief, Yves; White, Christopher
2010-11-01
Polymer addition is known to reduce drag in wall-bounded flows up to an asymptotic state called maximum drag reduction (MDR). The definition of MDR is still largely empirical and its uniqueness is a matter of debate. Using direct numerical simulations, a correspondence is first established between MDR and a specific state of transition in boundary layer flow. A model is derived as a function of the flow topology of the transitional Newtonian flow and the FENE-P model. The model is then extended to natural convection where heat transfer reduction (HTR) and augmentation (HTA) are observed as a function of polymer length. Yet, HTR and HTA are topologically equivalent and again correspond to a transitional state of Rayleigh Benard convection flow. This suggests that polymer-modified turbulence may be predictable as a function of the polymer solution's properties and transitional states of the corresponding Newtonian flow.
Yost, S.A.
1991-05-01
Radom matrix models based on an integral over supermatrices are proposed as a natural extension of bosonic matrix models. The subtle nature of superspace integration allows these models to have very different properties from the analogous bosonic models. Two choices of integration slice are investigated. One leads to a perturbative structure which is reminiscent of, and perhaps identical to, the usual Hermitian matrix models. Another leads to an eigenvalue reduction which can be described by a two component plasma in one dimension. A stationary point of the model is described.
This presentation presented information on entrainment models. Entrainment models use entrainment hypotheses to express the continuity equation. The advantage is that plume boundaries are known. A major disadvantage is that the problems that can be solved are rather simple. The ...
ERIC Educational Resources Information Center
James, W. G. G.
1970-01-01
Discusses the historical development of both the wave and the corpuscular photon model of light. Suggests that students should be informed that the two models are complementary and that each model successfully describes a wide range of radiation phenomena. Cites 19 references which might be of interest to physics teachers and students. (LC)
Hydrological models are mediating models
NASA Astrophysics Data System (ADS)
Babel, L. V.; Karssenberg, D.
2013-08-01
Despite the increasing role of models in hydrological research and decision-making processes, only few accounts of the nature and function of models exist in hydrology. Earlier considerations have traditionally been conducted while making a clear distinction between physically-based and conceptual models. A new philosophical account, primarily based on the fields of physics and economics, transcends classes of models and scientific disciplines by considering models as "mediators" between theory and observations. The core of this approach lies in identifying models as (1) being only partially dependent on theory and observations, (2) integrating non-deductive elements in their construction, and (3) carrying the role of instruments of scientific enquiry about both theory and the world. The applicability of this approach to hydrology is evaluated in the present article. Three widely used hydrological models, each showing a different degree of apparent physicality, are confronted to the main characteristics of the "mediating models" concept. We argue that irrespective of their kind, hydrological models depend on both theory and observations, rather than merely on one of these two domains. Their construction is additionally involving a large number of miscellaneous, external ingredients, such as past experiences, model objectives, knowledge and preferences of the modeller, as well as hardware and software resources. We show that hydrological models convey the role of instruments in scientific practice by mediating between theory and the world. It results from these considerations that the traditional distinction between physically-based and conceptual models is necessarily too simplistic and refers at best to the stage at which theory and observations are steering model construction. The large variety of ingredients involved in model construction would deserve closer attention, for being rarely explicitly presented in peer-reviewed literature. We believe that devoting
Model Experiments and Model Descriptions
NASA Technical Reports Server (NTRS)
Jackman, Charles H.; Ko, Malcolm K. W.; Weisenstein, Debra; Scott, Courtney J.; Shia, Run-Lie; Rodriguez, Jose; Sze, N. D.; Vohralik, Peter; Randeniya, Lakshman; Plumb, Ian
1999-01-01
The Second Workshop on Stratospheric Models and Measurements Workshop (M&M II) is the continuation of the effort previously started in the first Workshop (M&M I, Prather and Remsberg [1993]) held in 1992. As originally stated, the aim of M&M is to provide a foundation for establishing the credibility of stratospheric models used in environmental assessments of the ozone response to chlorofluorocarbons, aircraft emissions, and other climate-chemistry interactions. To accomplish this, a set of measurements of the present day atmosphere was selected. The intent was that successful simulations of the set of measurements should become the prerequisite for the acceptance of these models as having a reliable prediction for future ozone behavior. This section is divided into two: model experiment and model descriptions. In the model experiment, participant were given the charge to design a number of experiments that would use observations to test whether models are using the correct mechanisms to simulate the distributions of ozone and other trace gases in the atmosphere. The purpose is closely tied to the needs to reduce the uncertainties in the model predicted responses of stratospheric ozone to perturbations. The specifications for the experiments were sent out to the modeling community in June 1997. Twenty eight modeling groups responded to the requests for input. The first part of this section discusses the different modeling group, along with the experiments performed. Part two of this section, gives brief descriptions of each model as provided by the individual modeling groups.
NASA Technical Reports Server (NTRS)
Druyan, Leonard M.
2012-01-01
Climate models is a very broad topic, so a single volume can only offer a small sampling of relevant research activities. This volume of 14 chapters includes descriptions of a variety of modeling studies for a variety of geographic regions by an international roster of authors. The climate research community generally uses the rubric climate models to refer to organized sets of computer instructions that produce simulations of climate evolution. The code is based on physical relationships that describe the shared variability of meteorological parameters such as temperature, humidity, precipitation rate, circulation, radiation fluxes, etc. Three-dimensional climate models are integrated over time in order to compute the temporal and spatial variations of these parameters. Model domains can be global or regional and the horizontal and vertical resolutions of the computational grid vary from model to model. Considering the entire climate system requires accounting for interactions between solar insolation, atmospheric, oceanic and continental processes, the latter including land hydrology and vegetation. Model simulations may concentrate on one or more of these components, but the most sophisticated models will estimate the mutual interactions of all of these environments. Advances in computer technology have prompted investments in more complex model configurations that consider more phenomena interactions than were possible with yesterday s computers. However, not every attempt to add to the computational layers is rewarded by better model performance. Extensive research is required to test and document any advantages gained by greater sophistication in model formulation. One purpose for publishing climate model research results is to present purported advances for evaluation by the scientific community.
Braby, L.A.
1990-09-01
The biological effects of ionizing radiation exposure are the result of a complex sequence of physical, chemical, biochemical, and physiological interactions. One way to begin a search for an understanding of health effects of radiation is through the development of phenomenological models of the response. Many models have been presented and tested in the slowly evolving process of characterizing cellular response. A range of models covering different endpoints and phenomena has developed in parallel. Many of these models employ similar assumptions about some underlying processes while differing about the nature of others. An attempt is made to organize many of the models into groups with similar features and to compare the consequences of those features with the actual experimental observations. It is assumed that by showing that some assumptions are inconsistent with experimental observations, the job of devising and testing mechanistic models can be simplified. 43 refs., 13 figs.
NASA Technical Reports Server (NTRS)
Tao, Wei-Kuo; Moncrieff, Mitchell; Einaud, Franco (Technical Monitor)
2001-01-01
Numerical cloud models have been developed and applied extensively to study cloud-scale and mesoscale processes during the past four decades. The distinctive aspect of these cloud models is their ability to treat explicitly (or resolve) cloud-scale dynamics. This requires the cloud models to be formulated from the non-hydrostatic equations of motion that explicitly include the vertical acceleration terms since the vertical and horizontal scales of convection are similar. Such models are also necessary in order to allow gravity waves, such as those triggered by clouds, to be resolved explicitly. In contrast, the hydrostatic approximation, usually applied in global or regional models, does allow the presence of gravity waves. In addition, the availability of exponentially increasing computer capabilities has resulted in time integrations increasing from hours to days, domain grids boxes (points) increasing from less than 2000 to more than 2,500,000 grid points with 500 to 1000 m resolution, and 3-D models becoming increasingly prevalent. The cloud resolving model is now at a stage where it can provide reasonably accurate statistical information of the sub-grid, cloud-resolving processes poorly parameterized in climate models and numerical prediction models.
V. Chipman
2002-10-05
The purpose of the Ventilation Model is to simulate the heat transfer processes in and around waste emplacement drifts during periods of forced ventilation. The model evaluates the effects of emplacement drift ventilation on the thermal conditions in the emplacement drifts and surrounding rock mass, and calculates the heat removal by ventilation as a measure of the viability of ventilation to delay the onset of peak repository temperature and reduce its magnitude. The heat removal by ventilation is temporally and spatially dependent, and is expressed as the fraction of heat carried away by the ventilation air compared to the fraction of heat produced by radionuclide decay. One minus the heat removal is called the wall heat fraction, or the remaining amount of heat that is transferred via conduction to the surrounding rock mass. Downstream models, such as the ''Multiscale Thermohydrologic Model'' (BSC 2001), use the wall heat fractions as outputted from the Ventilation Model to initialize their post-closure analyses. The Ventilation Model report was initially developed to analyze the effects of preclosure continuous ventilation in the Engineered Barrier System (EBS) emplacement drifts, and to provide heat removal data to support EBS design. Revision 00 of the Ventilation Model included documentation of the modeling results from the ANSYS-based heat transfer model. The purposes of Revision 01 of the Ventilation Model are: (1) To validate the conceptual model for preclosure ventilation of emplacement drifts and verify its numerical application in accordance with new procedural requirements as outlined in AP-SIII-10Q, Models (Section 7.0). (2) To satisfy technical issues posed in KTI agreement RDTME 3.14 (Reamer and Williams 2001a). Specifically to demonstrate, with respect to the ANSYS ventilation model, the adequacy of the discretization (Section 6.2.3.1), and the downstream applicability of the model results (i.e. wall heat fractions) to initialize post
Energy spectra in elasto-inertial turbulence
NASA Astrophysics Data System (ADS)
Valente, P. C.; da Silva, C. B.; Pinho, F. T.
2016-07-01
Direct numerical simulations of statistically steady homogeneous isotropic turbulence in viscoelastic fluids described by the FENE-P model are presented. Emphasis is given to large polymer relaxation times compared to the eddy turnover time, which is a regime recently termed elasto-inertial turbulence. In this regime the polymers are ineffective in dissipating kinetic energy but they play a lead role in transferring kinetic energy to the small solvent scales which turns out to be concomitant with the depletion of the usual non-linear energy cascade. However, we show that the non-linear interactions are still highly active, but they lead to no net downscale energy transfer because the forward and reversed energy cascades are nearly balanced. Finally, we show that the tendency for a steeper elasto-inertial power-law spectra is reversed for large polymer relaxation times and the spectra tend towards the usual k-5/3 functional form.
Streak instability in viscoelastic Couette flow
NASA Astrophysics Data System (ADS)
Biancofiore, Luca; Brandt, Luca; Zaki, Tamer
2015-11-01
The secondary instability of streaks and transition to turbulence in viscoelastic Couette flow are studied using direct numerical simulations (DNS). Viscoelasticity is modeled using the FENE-P constitutive equations, and both the polymer concentration and Weissenberg number are varied in order to assess their effect on transition at moderate Reynolds number, Re = 400 .The base streaks are obtained from nonlinear simulations of the Couette flow response to a streamwise vortex, and can be classified as quasi-Newtonian streaks according to the terminology introduced by Page & Zaki (2014). At every streak amplitude of interest, harmonic forcing is introduced to trigger the secondary instability and breakdown to turbulence. The critical amplitude of this forcing decreases at higher Weissenberg number and also with increasing polymer concentration. The results demonstrate the destabilizing effect of elasticity at moderate Reynolds numbers.
Model Selection for Geostatistical Models
Hoeting, Jennifer A.; Davis, Richard A.; Merton, Andrew A.; Thompson, Sandra E.
2006-02-01
We consider the problem of model selection for geospatial data. Spatial correlation is typically ignored in the selection of explanatory variables and this can influence model selection results. For example, the inclusion or exclusion of particular explanatory variables may not be apparent when spatial correlation is ignored. To address this problem, we consider the Akaike Information Criterion (AIC) as applied to a geostatistical model. We offer a heuristic derivation of the AIC in this context and provide simulation results that show that using AIC for a geostatistical model is superior to the often used approach of ignoring spatial correlation in the selection of explanatory variables. These ideas are further demonstrated via a model for lizard abundance. We also employ the principle of minimum description length (MDL) to variable selection for the geostatistical model. The effect of sampling design on the selection of explanatory covariates is also explored.
ERIC Educational Resources Information Center
Oh, Phil Seok; Oh, Sung Jin
2013-01-01
Modeling in science has been studied by education researchers for decades and is now being applied broadly in school. It is among the scientific practices featured in the "Next Generation Science Standards" ("NGSS") (Achieve Inc. 2013). This article describes modeling activities in an extracurricular science club in a high…
ERIC Educational Resources Information Center
Budiansky, Stephen
1980-01-01
This article discusses the need for more accurate and complete input data and field verification of the various models of air pollutant dispension. Consideration should be given to changing the form of air quality standards based on enhanced dispersion modeling techniques. (Author/RE)
Forbus, Kenneth D
2011-07-01
Qualitative modeling concerns the representations and reasoning that people use to understand continuous aspects of the world. Qualitative models formalize everyday notions of causality and provide accounts of how to ground symbolic, relational representations in perceptual processes. This article surveys the basic ideas of qualitative modeling and their applications from a cognitive science perspective. It describes the basic principles of qualitative modeling, and a variety of qualitative representations that have been developed for quantities and for relationships between them, providing a kind of qualitative mathematics. Three ontological frameworks for organizing modeling knowledge (processes, components, and field) are summarized, along with research on automatically assembling models for particular tasks from such knowledge. Qualitative simulation and how it carves up time into meaningful units is discussed. We discuss several accounts of causal reasoning about dynamical systems, based on different choices of qualitative mathematics and ontology. Qualitative spatial reasoning is explored, both in terms of relational systems and visual reasoning. Applications of qualitative models of particular interest to cognitive scientists are described, including how they have been used to capture the expertise of scientists and engineers and how they have been used in education. Open questions and frontiers are also discussed, focusing on relationships between ideas developed in the qualitative modeling community and other areas of cognitive science. WIREs Cogni Sci 2011 2 374-391 DOI: 10.1002/wcs.115 For further resources related to this article, please visit the WIREs website.
NASA Technical Reports Server (NTRS)
Bardina, Jorge E.
1995-01-01
The objective of this work is to develop, verify, and incorporate the baseline two-equation turbulence models which account for the effects of compressibility into the three-dimensional Reynolds averaged Navier-Stokes (RANS) code and to provide documented descriptions of the models and their numerical procedures so that they can be implemented into 3-D CFD codes for engineering applications.
Climate models and model evaluation
Gates, W.L.
1994-12-31
This brief overview addresses aspects of the nature, uses, evaluation and limitations of climate models. A comprehensive global modeling capability has been achieved only for the physical climate system, which is characterized by processes that serve to transport and exchange momentum, heat and moisture within and between the atmosphere, ocean and land surface. The fundamental aim of climate modeling, and the justification for the use of climate models, is the need to achieve a quantitative understanding of the operation of the climate system and to exploit any potential predictability that may exist.
Veronica J. Rutledge
2013-01-01
The absence of industrial scale nuclear fuel reprocessing in the U.S. has precluded the necessary driver for developing the advanced simulation capability now prevalent in so many other countries. Thus, it is essential to model complex series of unit operations to simulate, understand, and predict inherent transient behavior and feedback loops. A capability of accurately simulating the dynamic behavior of advanced fuel cycle separation processes will provide substantial cost savings and many technical benefits. The specific fuel cycle separation process discussed in this report is the off-gas treatment system. The off-gas separation consists of a series of scrubbers and adsorption beds to capture constituents of interest. Dynamic models are being developed to simulate each unit operation involved so each unit operation can be used as a stand-alone model and in series with multiple others. Currently, an adsorption model has been developed within Multi-physics Object Oriented Simulation Environment (MOOSE) developed at the Idaho National Laboratory (INL). Off-gas Separation and REcoverY (OSPREY) models the adsorption of off-gas constituents for dispersed plug flow in a packed bed under non-isothermal and non-isobaric conditions. Inputs to the model include gas, sorbent, and column properties, equilibrium and kinetic data, and inlet conditions. The simulation outputs component concentrations along the column length as a function of time from which breakthrough data is obtained. The breakthrough data can be used to determine bed capacity, which in turn can be used to size columns. It also outputs temperature along the column length as a function of time and pressure drop along the column length. Experimental data and parameters were input into the adsorption model to develop models specific for krypton adsorption. The same can be done for iodine, xenon, and tritium. The model will be validated with experimental breakthrough curves. Customers will be given access to
Numerical simulations of non-homogeneous viscoelastic turbulent channel flow
NASA Astrophysics Data System (ADS)
Housiadas, Kostas; Beris, Antony
2004-11-01
The effect of the polymer mixing in turbulent channel flow is studied through numerical simulations, using a spectral technique. In particular, we simulate injection of polymeric material through a slit very close to the wall and parallel to it in pre-established Newtonian turbulent flow. The governing equations consist of the mass conservation, the modified Navier-Stokes equation (in order to take into account the polymer extra-stress), the evolution equation for the conformation tensor and an advection-diffusion equation for the polymer concentration. The injection process is simulated by dividing the computational domain in three different regions: (a) the entrance region where the polymer is introduced (b) the developing region where the polymer is allowed to convect freely interacting/modifying the turbulent flow and (c) the recovering region where we use a reacting sink to force the removal of the polymer from the solvent in order to re-establish the inlet conditions. A fully spectral method is used in order to solve the set of governing equations similar to that developed for homogenous viscoelastic turbulent DNS (Housiadas & Beris, Phys. Fluids, 15, (2003)). Although a significantly improved numerical algorithm has been successfully used before (Housiadas & Beris, to appear in J. Non-Newt. Fluid Mech. (2004)) a further improved version of that algorithm is presented in this work. The new algorithm has enabled us to extend the simulations for much wider range of viscoelasticity parameter values as well as for many viscoelastic models like the FENE-P, Giesekus, Oldroyd-B and the modified Giesekus/FENE-P model. Results for illustrative sets of parameter values are going to be presented.
Kim, Kyoungyoun; Sureshkumar, Radhakrishna
2013-06-01
To study the influence of dynamic interactions between turbulent vortical structures and polymer stress on turbulent friction drag reduction, a series of simulations of channel flow is performed. We obtain self-consistent evolution of an initial eddy in the presence of polymer stresses by utilizing the finitely extensible nonlinear elastic-Peterlin (FENE-P) model. The initial eddy is extracted by the conditional averages for the second quadrant event from fully turbulent Newtonian flow, and the initial polymer conformation fields are given by the solutions of the FENE-P model equations corresponding to the mean shear flow in the Newtonian case. At a relatively low Weissenberg number We(τ) (=50), defined as the ratio of the polymer relaxation time to the wall time scale, the generation of new vortices is inhibited by polymer-induced countertorques. Thus fewer vortices are generated in the buffer layer. However, the head of the primary hairpin is unaffected by the polymer stress. At larger We(τ) values (≥100), the hairpin head becomes weaker and vortex autogeneration and Reynolds stress growth are almost entirely suppressed. The temporal evolution of the vortex strength and polymer torque magnitude reveals that polymer extension by the vortical motion results in a polymer torque that increases in magnitude with time until a maximum value is reached over a time scale comparable to the polymer relaxation time. The polymer torque retards the vortical motion and Reynolds stress production, which in turn weakens flow-induced chain extension and torque itself. An analysis of the vortex time scales reveals that with increasing We(τ), vortical motions associated with a broader range of time scales are affected by the polymer stress. This is qualitatively consistent with Lumley's time criterion for the onset of drag reduction.
Mitchell, W.D.
1972-01-01
Model hydrographs are composed of pairs of dimensionless ratios, arrayed in tabular form, which, when modified by the appropriate values of rainfall exceed and by the time and areal characteristics of the drainage basin, satisfactorily represent the flood hydrograph for the basin. Model bydrographs are developed from a dimensionless translation hydrograph, having a time base of T hours and appropriately modified for storm duration by routing through reservoir storage, S=kOx. Models fall into two distinct classes: (1) those for which the value of x is unity and which have all the characteristics of true unit hydrographs and (2) those for which the value of x is other than unity and to which the unit-hydrograph principles of proportionality and superposition do not apply. Twenty-six families of linear models and eight families of nonlinear models in tabular form from the principal subject of this report. Supplemental discussions describe the development of the models and illustrate their application. Other sections of the report, supplemental to the tables, describe methods of determining the hydrograph characteristics, T, k, and x, both from observed hydrograph and from the physical characteristics of the drainage basin. Five illustrative examples of use show that the models, when properly converted to incorporate actual rainfall excess and the time and areal characteristics of the drainage basins, do indeed satisfactorily represent the observed flood hydrographs for the basins.
NASA Astrophysics Data System (ADS)
Grimaldi, P.
2012-07-01
These mandatory guidelines are provided for preparation of papers accepted for publication in the series of Volumes of The The stereometric modelling means modelling achieved with : - the use of a pair of virtual cameras, with parallel axes and positioned at a mutual distance average of 1/10 of the distance camera-object (in practice the realization and use of a stereometric camera in the modeling program); - the shot visualization in two distinct windows - the stereoscopic viewing of the shot while modelling. Since the definition of "3D vision" is inaccurately referred to as the simple perspective of an object, it is required to add the word stereo so that "3D stereo vision " shall stand for "three-dimensional view" and ,therefore, measure the width, height and depth of the surveyed image. Thanks to the development of a stereo metric model , either real or virtual, through the "materialization", either real or virtual, of the optical-stereo metric model made visible with a stereoscope. It is feasible a continuous on line updating of the cultural heritage with the help of photogrammetry and stereometric modelling. The catalogue of the Architectonic Photogrammetry Laboratory of Politecnico di Bari is available on line at: http://rappresentazione.stereofot.it:591/StereoFot/FMPro?-db=StereoFot.fp5&-lay=Scheda&-format=cerca.htm&-view
ERIC Educational Resources Information Center
Lin, Tony; Erfan, Sasan
2016-01-01
Mathematical modeling is an open-ended research subject where no definite answers exist for any problem. Math modeling enables thinking outside the box to connect different fields of studies together including statistics, algebra, calculus, matrices, programming and scientific writing. As an integral part of society, it is the foundation for many…
NASA Astrophysics Data System (ADS)
Regardt, Olle; Rönnbäck, Lars; Bergholtz, Maria; Johannesson, Paul; Wohed, Petia
Maintaining and evolving data warehouses is a complex, error prone, and time consuming activity. The main reason for this state of affairs is that the environment of a data warehouse is in constant change, while the warehouse itself needs to provide a stable and consistent interface to information spanning extended periods of time. In this paper, we propose a modeling technique for data warehousing, called anchor modeling, that offers non-destructive extensibility mechanisms, thereby enabling robust and flexible management of changes in source systems. A key benefit of anchor modeling is that changes in a data warehouse environment only require extensions, not modifications, to the data warehouse. This ensures that existing data warehouse applications will remain unaffected by the evolution of the data warehouse, i.e. existing views and functions will not have to be modified as a result of changes in the warehouse model.
Daniel, David J; Mc Pherson, Allen; Thorp, John R; Barrett, Richard; Clay, Robert; De Supinski, Bronis; Dube, Evi; Heroux, Mike; Janssen, Curtis; Langer, Steve; Laros, Jim
2011-01-14
A programming model is a set of software technologies that support the expression of algorithms and provide applications with an abstract representation of the capabilities of the underlying hardware architecture. The primary goals are productivity, portability and performance.
ERIC Educational Resources Information Center
Taylor, Emma
1991-01-01
A cheap and simple model that can be made and used by pupils to study the human breathing mechanism is presented. A list of needed materials, procedures for construction, possible refinements, and method of use are included. (KR)
NASA Technical Reports Server (NTRS)
Guillet, J. E.
1984-01-01
A reaction kinetics based model of the photodegradation process, which measures all important rate constants, and a computerized model capable of predicting the photodegradation rate and failure modes of a 30 year period, were developed. It is shown that the computerized photodegradation model for polyethylene correctly predicts failure of ELVAX 15 and cross linked ELVAX 150 on outdoor exposure. It is indicated that cross linking ethylene vinyl acetate (EVA) does not significantly change its degradation rate. It is shown that the effect of the stabilizer package is approximately equivalent on both polymers. The computerized model indicates that peroxide decomposers and UV absorbers are the most effective stabilizers. It is found that a combination of UV absorbers and a hindered amine light stabilizer (HALS) is the most effective stabilizer system.
EPA's modeling community is working to gain insights into certain parts of a physical, biological, economic, or social system by conducting environmental assessments for Agency decision making to complex environmental issues.
Energy models characterize the energy system, its evolution, and its interactions with the broader economy. The energy system consists of primary resources, including both fossil fuels and renewables; power plants, refineries, and other technologies to process and convert these r...
Ray, R.M. )
1986-12-01
PREDICTIVE MODELS is a collection of five models - CFPM, CO2PM, ICPM, PFPM, and SFPM - used in the 1982-1984 National Petroleum Council study of enhanced oil recovery (EOR) potential. Each pertains to a specific EOR process designed to squeeze additional oil from aging or spent oil fields. The processes are: 1) chemical flooding, where soap-like surfactants are injected into the reservoir to wash out the oil; 2) carbon dioxide miscible flooding, where carbon dioxide mixes with the lighter hydrocarbons making the oil easier to displace; 3) in-situ combustion, which uses the heat from burning some of the underground oil to thin the product; 4) polymer flooding, where thick, cohesive material is pumped into a reservoir to push the oil through the underground rock; and 5) steamflood, where pressurized steam is injected underground to thin the oil. CFPM, the Chemical Flood Predictive Model, models micellar (surfactant)-polymer floods in reservoirs, which have been previously waterflooded to residual oil saturation. Thus, only true tertiary floods are considered. An option allows a rough estimate of oil recovery by caustic or caustic-polymer processes. CO2PM, the Carbon Dioxide miscible flooding Predictive Model, is applicable to both secondary (mobile oil) and tertiary (residual oil) floods, and to either continuous CO2 injection or water-alternating gas processes. ICPM, the In-situ Combustion Predictive Model, computes the recovery and profitability of an in-situ combustion project from generalized performance predictive algorithms. PFPM, the Polymer Flood Predictive Model, is switch-selectable for either polymer or waterflooding, and an option allows the calculation of the incremental oil recovery and economics of polymer relative to waterflooding. SFPM, the Steamflood Predictive Model, is applicable to the steam drive process, but not to cyclic steam injection (steam soak) processes.
Model selection for geostatistical models.
Hoeting, Jennifer A; Davis, Richard A; Merton, Andrew A; Thompson, Sandra E
2006-02-01
We consider the problem of model selection for geospatial data. Spatial correlation is often ignored in the selection of explanatory variables, and this can influence model selection results. For example, the importance of particular explanatory variables may not be apparent when spatial correlation is ignored. To address this problem, we consider the Akaike Information Criterion (AIC) as applied to a geostatistical model. We offer a heuristic derivation of the AIC in this context and provide simulation results that show that using AIC for a geostatistical model is superior to the often-used traditional approach of ignoring spatial correlation in the selection of explanatory variables. These ideas are further demonstrated via a model for lizard abundance. We also apply the principle of minimum description length (MDL) to variable selection for the geostatistical model. The effect of sampling design on the selection of explanatory covariates is also explored. R software to implement the geostatistical model selection methods described in this paper is available in the Supplement.
The Extensional Rheology of Non-Newtonian Materials
NASA Technical Reports Server (NTRS)
Spiegelberg, Stephen H.; McKinley, Gareth H.
1996-01-01
The evolution of the transient extensional stresses in dilute and semi-dilute viscoelastic polymer solutions are measured with a filament stretching rheometer of a design similar to that first introduced by Sridhar, et al. The solutions are polystyrene-based (PS) Boger fluids that are stretched at constant strain rates ranging from 0.6 less than or equal to epsilon(0) less than or equal to 4s(exp -1) and to Hencky strains of epsilon greater than 4. The test fluids all strain harden and Trouton ratios exceeding 1000 are obtained at high strains. The experimental data strain hardens at lower strain levels than predicted by bead-spring FENE models. In addition to measuring the transient tensile stress growth, we also monitor the decay of the tensile viscoelastic stress difference in the fluid column following cessation of uniaxial elongation as a function of the total imposed Hencky strain and the strain rate. The extensional stresses initially decay very rapidly upon cessation of uniaxial elongation followed by a slower viscoelastic relaxation, and deviate significantly from FENE relaxation predictions. The relaxation at long times t is greater than or equal to 5 s, is compromised by gravitational draining leading to non-uniform filament profiles. For the most elastic fluids, partial decohension of the fluid filament from the endplates of the rheometer is observed in tests conducted at high strain rates. This elastic instability is initiated near the rigid endplate fixtures of the device and it results in the progressive breakup of the fluid column into individual threads or 'fibrils' with a regular azimuthal spacing. These fibrils elongate and bifurcate as the fluid sample is elongated further. Flow visualization experiments using a modified stretching device show that the instability develops as a consequence of an axisymmetry-breaking meniscus instability in the nonhomogeneous region of highly deformed fluid near the rigid endplate.
Scalable Models Using Model Transformation
2008-07-13
huge number of web documents. We have created a simplified demo using 5 worker machines in the Ptolemy II modeling and simulation environment [3], as...the pattern of the transformation rule matches any subgraph of the input model. When the TransformationRule actor is opened in the Ptolemy II GUI...tool developed in the Ptolemy II frame- work, existing tools include AGG [14], PROGRES [15], AToM3 [16], FUJABA [17], VIATRA2 [18], and GReAT [19
NASA Technical Reports Server (NTRS)
Denning, Peter J.
1990-01-01
Although powerful computers have allowed complex physical and manmade hardware systems to be modeled successfully, we have encountered persistent problems with the reliability of computer models for systems involving human learning, human action, and human organizations. This is not a misfortune; unlike physical and manmade systems, human systems do not operate under a fixed set of laws. The rules governing the actions allowable in the system can be changed without warning at any moment, and can evolve over time. That the governing laws are inherently unpredictable raises serious questions about the reliability of models when applied to human situations. In these domains, computers are better used, not for prediction and planning, but for aiding humans. Examples are systems that help humans speculate about possible futures, offer advice about possible actions in a domain, systems that gather information from the networks, and systems that track and support work flows in organizations.
NASA Technical Reports Server (NTRS)
Smith, J. A. (Principal Investigator)
1985-01-01
The overall goal of this work has been to develop a set of computational tools and media abstractions for the terrain bidirectional reflectance problem. The modeling of soil and vegetation surfaces has been emphasized with a gradual increase in the complexity of the media geometries treated. Pragmatic problems involved in the combined modeling of soil, vegetation, and atmospheric effects have been of interest and one of the objectives has been to describe the canopy reflectance problem in a classical radiative transfer sense permitting easier inclusion of our work by other workers in the radiative transfer field.
Woosley, S.E.; Weaver, T.A.
1980-01-01
Recent progress in understanding the observed properties of Type I supernovae as a consequence of the thermonuclear detonation of white dwarf stars and the ensuing decay of the /sup 56/Ni produced therein is reviewed. Within the context of this model for Type I explosions and the 1978 model for Type II explosions, the expected nucleosynthesis and gamma-line spectra from both kinds of supernovae are presented. Finally, a qualitatively new approach to the problem of massive star death and Type II supernovae based upon a combination of rotation and thermonuclear burning is discussed.
Pradeep, Chullikkattil P; Li, Feng-Yan; Lydon, Claire; Miras, Haralampos N; Long, De-Liang; Xu, Lin; Cronin, Leroy
2011-06-27
A series of tris(hydroxymethyl)aminomethane (TRIS)-based linear (bis(TRIS)) and triangular (tris(TRIS)) ligands has been synthesised and were covalently attached to the Wells-Dawson type cluster [P(2)V(3)W(15)O(62)](9-) to generate a series of nanometer-sized inorganic-organic hybrid polyoxometalate clusters. These huge hybrids, with a molecular mass similar to that of small proteins in the range of ≈10-16 kDa, were unambiguously characterised by using high-resolution ESI-MS. The ESI-MS spectra of these compounds revealed, in negative ion mode, a characteristic pattern showing distinct groups of peaks corresponding to different anionic charge states ranging from 3(-) to 8(-) for the hybrids. Each peak in these individual groups could be unambiguously assigned to the corresponding hybrid cluster anion with varying combinations of tetrabutylammonium (TBA) and other cations. This study therefore highlights the prowess of the high-resolution ESI-MS for the unambiguous characterisation of large, nanoscale, inorganic-organic hybrid clusters that have huge mass, of the order of 10-16 kDa. Also, the designed synthesis of these compounds points to the fact that we were able to achieve a great deal of structural pre-design in the synthesis of these inorganic-organic hybrid polyoxometalates (POMs) by means of a ligand design route, which is often not possible in traditional "one-pot" POM synthesis.
Chen, He; Chen, Shengping; Jiang, Zongfu; Hou, Jing
2015-12-01
We report the direct generation of 0.4 μJ, 7 kW ultrabroadband picosecond noise-like pulses from an Yb-doped all-fiber oscillator based on dual nonlinear optical loop mirrors (NOLMs). Under the highest pump power, the average power of the main output port reached 1.4 W, and the 3 dB spectral bandwidths reached 76 nm and 165 nm from the two output ports, respectively. The design of dual-NOLMs shows both exceptional compactness in construction and distinct flexibility on the engineering of the mode-locking behaviors. To the best of our knowledge, this is the first demonstration of a watt-level dual-NOLM-based fiber laser. Based on this laser, the pulse energy and peak power of picosecond noise-like pulse from an all-fiber oscillator have been elevated by an order of magnitude.
NASA Astrophysics Data System (ADS)
Fragiadakis, D.; Roland, C. M.
2014-05-01
Molecular dynamics simulations were carried out on a series of Lennard-Jones binary mixtures of rigid, asymmetric, dumbbell-shaped molecules. Below an onset temperature, the rotational and translational dynamics split into the slow structural α relaxation and a higher-frequency Johari-Goldstein β relaxation. Both processes are dynamically heterogeneous, having broad distributions of relaxation times. However, only the α relaxation shows strong dynamic correlations; correlations at the β time scale are weak, in particular for molecules having shorter bonds. Despite the close connection between the two processes, we find no correlation between the α and β relaxation times of individual molecules; that is, a molecule exhibiting slow β motion does not necessarily undergo slow α dynamics and likewise for fast molecules. However, the single-molecule α relaxation times do correlate with both the α and β relaxation strengths.
Ensemble forecasting has been used for operational numerical weather prediction in the United States and Europe since the early 1990s. An ensemble of weather or climate forecasts is used to characterize the two main sources of uncertainty in computer models of physical systems: ...
ERIC Educational Resources Information Center
Ebert, James R.; Elliott, Nancy A.; Hurteau, Laura; Schulz, Amanda
2004-01-01
Students must understand the fundamental process of convection before they can grasp a wide variety of Earth processes, many of which may seem abstract because of the scales on which they operate. Presentation of a very visual, concrete model prior to instruction on these topics may facilitate students' understanding of processes that are largely…
NASA Astrophysics Data System (ADS)
Baart, F.; Donchyts, G.; van Dam, A.; Plieger, M.
2015-12-01
The emergence of interactive art has blurred the line between electronic, computer graphics and art. Here we apply this art form to numerical models. Here we show how the transformation of a numerical model into an interactive painting can both provide insights and solve real world problems. The cases that are used as an example include forensic reconstructions, dredging optimization, barrier design. The system can be fed using any source of time varying vector fields, such as hydrodynamic models. The cases used here, the Indian Ocean (HYCOM), the Wadden Sea (Delft3D Curvilinear), San Francisco Bay (3Di subgrid and Delft3D Flexible Mesh), show that the method used is suitable for different time and spatial scales. High resolution numerical models become interactive paintings by exchanging their velocity fields with a high resolution (>=1M cells) image based flow visualization that runs in a html5 compatible web browser. The image based flow visualization combines three images into a new image: the current image, a drawing, and a uv + mask field. The advection scheme that computes the resultant image is executed in the graphics card using WebGL, allowing for 1M grid cells at 60Hz performance on mediocre graphic cards. The software is provided as open source software. By using different sources for a drawing one can gain insight into several aspects of the velocity fields. These aspects include not only the commonly represented magnitude and direction, but also divergence, topology and turbulence .
ERIC Educational Resources Information Center
Finger Lakes Regional Education Center for Economic Development, Mount Morris, NY.
This guide describes seven model programs that were developed by the Finger Lakes Regional Center for Economic Development (New York) to meet the training needs of female and minority entrepreneurs to help their businesses survive and grow and to assist disabled and dislocated workers and youth in beginning small businesses. The first three models…
Wolkenhauer, Olaf
2014-01-01
Next generation sequencing technologies are bringing about a renaissance of mining approaches. A comprehensive picture of the genetic landscape of an individual patient will be useful, for example, to identify groups of patients that do or do not respond to certain therapies. The high expectations may however not be satisfied if the number of patient groups with similar characteristics is going to be very large. I therefore doubt that mining sequence data will give us an understanding of why and when therapies work. For understanding the mechanisms underlying diseases, an alternative approach is to model small networks in quantitative mechanistic detail, to elucidate the role of gene and proteins in dynamically changing the functioning of cells. Here an obvious critique is that these models consider too few components, compared to what might be relevant for any particular cell function. I show here that mining approaches and dynamical systems theory are two ends of a spectrum of methodologies to choose from. Drawing upon personal experience in numerous interdisciplinary collaborations, I provide guidance on how to model by discussing the question "Why model?"
ERIC Educational Resources Information Center
Goodwyn, Lauren; Salm, Sarah
2007-01-01
Teaching the anatomy of the muscle system to high school students can be challenging. Students often learn about muscle anatomy by memorizing information from textbooks or by observing plastic, inflexible models. Although these mediums help students learn about muscle placement, the mediums do not facilitate understanding regarding integration of…
Although air quality models have been applied historically to address issues specific to ambient air quality standards (i.e., one criteria pollutant at a time) or welfare (e.g.. acid deposition or visibility impairment). they are inherently multipollutant based. Therefore. in pri...
A. Alsaed
2004-09-14
The ''Disposal Criticality Analysis Methodology Topical Report'' (YMP 2003) presents the methodology for evaluating potential criticality situations in the monitored geologic repository. As stated in the referenced Topical Report, the detailed methodology for performing the disposal criticality analyses will be documented in model reports. Many of the models developed in support of the Topical Report differ from the definition of models as given in the Office of Civilian Radioactive Waste Management procedure AP-SIII.10Q, ''Models'', in that they are procedural, rather than mathematical. These model reports document the detailed methodology necessary to implement the approach presented in the Disposal Criticality Analysis Methodology Topical Report and provide calculations utilizing the methodology. Thus, the governing procedure for this type of report is AP-3.12Q, ''Design Calculations and Analyses''. The ''Criticality Model'' is of this latter type, providing a process evaluating the criticality potential of in-package and external configurations. The purpose of this analysis is to layout the process for calculating the criticality potential for various in-package and external configurations and to calculate lower-bound tolerance limit (LBTL) values and determine range of applicability (ROA) parameters. The LBTL calculations and the ROA determinations are performed using selected benchmark experiments that are applicable to various waste forms and various in-package and external configurations. The waste forms considered in this calculation are pressurized water reactor (PWR), boiling water reactor (BWR), Fast Flux Test Facility (FFTF), Training Research Isotope General Atomic (TRIGA), Enrico Fermi, Shippingport pressurized water reactor, Shippingport light water breeder reactor (LWBR), N-Reactor, Melt and Dilute, and Fort Saint Vrain Reactor spent nuclear fuel (SNF). The scope of this analysis is to document the criticality computational method. The criticality
Electrophoresis of end-labeled DNA: Theory and experiment
NASA Astrophysics Data System (ADS)
Lau, Henry W.; Archer, Lynden A.
2010-03-01
The dynamic behavior of end-labeled DNA during free-solution electrophoresis is investigated using a simple dumbbell model for the labeled DNA. We study the effect of the applied field, label size, and chain stiffness on DNA conformation and electrophoretic mobility. High applied fields are predicted to magnify the size-dependence of mobility and to yield a nonmonotonic dependence of electrophoretic mobility on applied field. The effectiveness of leveraging label size and DNA chain stiffness for improving resolution is also discussed in the context of DNA deformation. To evaluate the most salient model predictions, we use capillary electrophoresis experiments to characterize the size- and field-dependent mobility of dsDNA fragments (300 bp-2 kbp) end-functionalized with streptavidin. Our experimental results are found to be in generally good accord with expectations based on the dumb-bell model. We discuss implications of these findings for fast, size-based separation of DNA in free solution.
NASA Technical Reports Server (NTRS)
2000-01-01
The molecule modeling method known as Multibody Order (N) Dynamics, or MBO(N)D, was developed by Moldyn, Inc. at Goddard Space Flight Center through funding provided by the SBIR program. The software can model the dynamics of molecules through technology which stimulates low-frequency molecular motions and properties, such as movements among a molecule's constituent parts. With MBO(N)D, a molecule is substructured into a set of interconnected rigid and flexible bodies. These bodies replace the computation burden of mapping individual atoms. Moldyn's technology cuts computation time while increasing accuracy. The MBO(N)D technology is available as Insight II 97.0 from Molecular Simulations, Inc. Currently the technology is used to account for forces on spacecraft parts and to perform molecular analyses for pharmaceutical purposes. It permits the solution of molecular dynamics problems on a moderate workstation, as opposed to on a supercomputer.
1980-02-01
three-dimensional gas turbine combustion chamber flows. ASME 23rd Int. Gas Turbine Conference. London (1978) 10). R.S. Reynolds, T.E. Kuhn & H.C. Mongia ... combustion data. 2 4 The concept of this global model approach is to trantform the TJI region in a physically compatible way that can be computationally...is also addressed.- ee a ot s um FUEL EFFECTS ON GAS TURBINE COMBUSTION : Fuel characteristics which are most likely to, affect the design- of future
NASA Astrophysics Data System (ADS)
Fossión, Rubén
2010-09-01
The atomic nucleus is a typical example of a many-body problem. On the one hand, the number of nucleons (protons and neutrons) that constitute the nucleus is too large to allow for exact calculations. On the other hand, the number of constituent particles is too small for the individual nuclear excitation states to be explained by statistical methods. Another problem, particular for the atomic nucleus, is that the nucleon-nucleon (n-n) interaction is not one of the fundamental forces of Nature, and is hard to put in a single closed equation. The nucleon-nucleon interaction also behaves differently between two free nucleons (bare interaction) and between two nucleons in the nuclear medium (dressed interaction). Because of the above reasons, specific nuclear many-body models have been devised of which each one sheds light on some selected aspects of nuclear structure. Only combining the viewpoints of different models, a global insight of the atomic nucleus can be gained. In this chapter, we revise the the Nuclear Shell Model as an example of the microscopic approach, and the Collective Model as an example of the geometric approach. Finally, we study the statistical properties of nuclear spectra, basing on symmetry principles, to find out whether there is quantum chaos in the atomic nucleus. All three major approaches have been rewarded with the Nobel Prize of Physics. In the text, we will stress how each approach introduces its own series of approximations to reduce the prohibitingly large number of degrees of freedom of the full many-body problem to a smaller manageable number of effective degrees of freedom.
NASA Technical Reports Server (NTRS)
Dill, David L.
1995-01-01
Automatic formal verification methods for finite-state systems, also known as model-checking, successfully reduce labor costs since they are mostly automatic. Model checkers explicitly or implicitly enumerate the reachable state space of a system, whose behavior is described implicitly, perhaps by a program or a collection of finite automata. Simple properties, such as mutual exclusion or absence of deadlock, can be checked by inspecting individual states. More complex properties, such as lack of starvation, require search for cycles in the state graph with particular properties. Specifications to be checked may consist of built-in properties, such as deadlock or 'unspecified receptions' of messages, another program or implicit description, to be compared with a simulation, bisimulation, or language inclusion relation, or an assertion in one of several temporal logics. Finite-state verification tools are beginning to have a significant impact in commercial designs. There are many success stories of verification tools finding bugs in protocols or hardware controllers. In some cases, these tools have been incorporated into design methodology. Research in finite-state verification has been advancing rapidly, and is showing no signs of slowing down. Recent results include probabilistic algorithms for verification, exploitation of symmetry and independent events, and the use symbolic representations for Boolean functions and systems of linear inequalities. One of the most exciting areas for further research is the combination of model-checking with theorem-proving methods.
Plimpton, Steven James; Heffernan, Julieanne; Sasaki, Darryl Yoshio; Frischknecht, Amalie Lucile; Stevens, Mark Jackson; Frink, Laura J. Douglas
2005-11-01
Understanding the properties and behavior of biomembranes is fundamental to many biological processes and technologies. Microdomains in biomembranes or ''lipid rafts'' are now known to be an integral part of cell signaling, vesicle formation, fusion processes, protein trafficking, and viral and toxin infection processes. Understanding how microdomains form, how they depend on membrane constituents, and how they act not only has biological implications, but also will impact Sandia's effort in development of membranes that structurally adapt to their environment in a controlled manner. To provide such understanding, we created physically-based models of biomembranes. Molecular dynamics (MD) simulations and classical density functional theory (DFT) calculations using these models were applied to phenomena such as microdomain formation, membrane fusion, pattern formation, and protein insertion. Because lipid dynamics and self-organization in membranes occur on length and time scales beyond atomistic MD, we used coarse-grained models of double tail lipid molecules that spontaneously self-assemble into bilayers. DFT provided equilibrium information on membrane structure. Experimental work was performed to further help elucidate the fundamental membrane organization principles.
NASA Astrophysics Data System (ADS)
Holmes, Jon L.
1999-06-01
Molecular modeling has trickled down from the realm of pharmaceutical and research laboratories into the realm of undergraduate chemistry instruction. It has opened avenues for the visualization of chemical concepts that previously were difficult or impossible to convey. I am sure that many of you have developed exercises using the various molecular modeling tools. It is the desire of this Journal to become an avenue for you to share these exercises among your colleagues. It is to this end that Ron Starkey has agreed to edit such a column and to publish not only the description of such exercises, but also the software documents they use. The WWW is the obvious medium to distribute this combination and so accepted submissions will appear online as a feature of JCE Internet. Typical molecular modeling exercise: finding conformation energies. Molecular Modeling Exercises and Experiments is the latest feature column of JCE Internet, joining Conceptual Questions and Challenge Problems, Hal's Picks, and Mathcad in the Chemistry Curriculum. JCE Internet continues to seek submissions in these areas of interest and submissions of general interest. If you have developed materials and would like to submit them, please see our Guide to Submissions for more information. The Chemical Education Resource Shelf, Equipment Buyers Guide, and WWW Site Review would also like to hear about chemistry textbooks and software, equipment, and WWW sites, respectively. Please consult JCE Internet Features to learn more about these resources at JCE Online. Email Announcements Would you like to be informed by email when the latest issue of the Journal is available online? when a new JCE Software title is shipping? when a new JCE Internet article has been published or is available for Open Review? when your subscription is about to expire? A new feature of JCE Online makes this possible. Visit our Guestbook to learn how. When
10. MOVABLE BED SEDIMENTATION MODELS. DOGTOOTH BEND MODEL (MODEL SCALE: ...
10. MOVABLE BED SEDIMENTATION MODELS. DOGTOOTH BEND MODEL (MODEL SCALE: 1' = 400' HORIZONTAL, 1' = 100' VERTICAL), AND GREENVILLE BRIDGE MODEL (MODEL SCALE: 1' = 360' HORIZONTAL, 1' = 100' VERTICAL). - Waterways Experiment Station, Hydraulics Laboratory, Halls Ferry Road, 2 miles south of I-20, Vicksburg, Warren County, MS
Students' Models of Curve Fitting: A Models and Modeling Perspective
ERIC Educational Resources Information Center
Gupta, Shweta
2010-01-01
The Models and Modeling Perspectives (MMP) has evolved out of research that began 26 years ago. MMP researchers use Model Eliciting Activities (MEAs) to elicit students' mental models. In this study MMP was used as the conceptual framework to investigate the nature of students' models of curve fitting in a problem-solving environment consisting of…
Vincent, Julian F V
2003-01-01
Biomimetics is seen as a path from biology to engineering. The only path from engineering to biology in current use is the application of engineering concepts and models to biological systems. However, there is another pathway: the verification of biological mechanisms by manufacture, leading to an iterative process between biology and engineering in which the new understanding that the engineering implementation of a biological system can bring is fed back into biology, allowing a more complete and certain understanding and the possibility of further revelations for application in engineering. This is a pathway as yet unformalized, and one that offers the possibility that engineers can also be scientists. PMID:14561351
Hydrodynamical Simulations of Colliding Jets: Modeling 3C 75
NASA Astrophysics Data System (ADS)
Molnar, S. M.; Schive, H.-Y.; Birkinshaw, M.; Chiueh, T.; Musoke, G.; Young, A. J.
2017-01-01
Radio observations suggest that 3C 75, located in the dumbbell shaped galaxy NGC 1128 at the center of Abell 400, hosts two colliding jets. Motivated by this source, we perform three-dimensional hydrodynamical simulations using a modified version of the GPU-accelerated Adaptive-MEsh-Refinement hydrodynamical parallel code (GAMER) to study colliding extragalactic jets. We find that colliding jets can be cast into two categories: (1) bouncing jets, in which case the jets bounce off each other keeping their identities, and (2) merging jets, when only one jet emerges from the collision. Under some conditions the interaction causes the jets to break up into oscillating filaments of opposite helicity, with consequences for their downstream stability. When one jet is significantly faster than the other and the impact parameter is small, the jets merge; the faster jet takes over the slower one. In the case of merging jets, the oscillations of the filaments, in projection, may show a feature that resembles a double helix, similar to the radio image of 3C 75. Thus we interpret the morphology of 3C 75 as a consequence of the collision of two jets with distinctly different speeds at a small impact parameter, with the faster jet breaking up into two oscillating filaments.
NASA Astrophysics Data System (ADS)
Gilbert, P. H.; Giacomin, A. J.
2016-10-01
Recent work has focused on deepening our understanding of the molecular origins of the higher harmonics that arise in the shear stress response of polymeric liquids in large-amplitude oscillatory shear flow. For instance, these higher harmonics have been explained by just considering the orientation distribution of rigid dumbbells suspended in a Newtonian solvent. These dumbbells, when in dilute suspension, form the simplest relevant molecular model of polymer viscoelasticity, and this model specifically neglects interactions between the polymer molecules [R. B. Bird et al., "Dilute rigid dumbbell suspensions in large-amplitude oscillatory shear flow: Shear stress response," J. Chem. Phys. 140, 074904 (2014)]. In this paper, we explore these interactions by examining the Curtiss-Bird model, a kinetic molecular theory designed specifically to account for the restricted motions that arise when polymer chains are concentrated, thus interacting and specifically, entangled. We begin our comparison using a heretofore ignored explicit analytical solution [X.-J. Fan and R. B. Bird, "A kinetic theory for polymer melts. VI. Calculation of additional material functions," J. Non-Newtonian Fluid Mech. 15, 341 (1984)]. For concentrated systems, the chain motion transverse to the chain axis is more restricted than along the axis. This anisotropy is described by the link tension coefficient, ɛ, for which several special cases arise: ɛ = 0 corresponds to reptation, ɛ > 1/8 to rod-climbing, 1/5 ≤ ɛ ≤ 3/4 to reasonable predictions for shear-thinning in steady simple shear flow, and ɛ = 1 to the dilute solution without hydrodynamic interaction. In this paper, we examine the shapes of the shear stress versus shear rate loops for the special cases ɛ = (" separators=" 0 , 1 / 8 , 3 / 8 , 1 ) , and we compare these with those of rigid dumbbell and reptation model predictions.
Pre-Modeling Ensures Accurate Solid Models
ERIC Educational Resources Information Center
Gow, George
2010-01-01
Successful solid modeling requires a well-organized design tree. The design tree is a list of all the object's features and the sequential order in which they are modeled. The solid-modeling process is faster and less prone to modeling errors when the design tree is a simple and geometrically logical definition of the modeled object. Few high…
Modeling metrology for calibration of OPC models
NASA Astrophysics Data System (ADS)
Mack, Chris A.; Raghunathan, Ananthan; Sturtevant, John; Deng, Yunfei; Zuniga, Christian; Adam, Kostas
2016-03-01
Optical Proximity Correction (OPC) has continually improved in accuracy over the years by adding more physically based models. Here, we further extend OPC modeling by adding the Analytical Linescan Model (ALM) to account for systematic biases in CD-SEM metrology. The ALM was added to a conventional OPC model calibration flow and the accuracy of the calibrated model with the ALM was compared to the standard model without the ALM using validation data. Without using any adjustable parameters in the ALM, OPC validation accuracy was improved by 5%. While very preliminary, these results give hope that modeling metrology could be an important next step in OPC model improvement.
Heterogeneous nucleation and shape transformation of multicomponent metallic nanostructures.
Kwon, Soon Gu; Krylova, Galyna; Phillips, Patrick J; Klie, Robert F; Chattopadhyay, Soma; Shibata, Tomohiro; Bunel, Emilio E; Liu, Yuzi; Prakapenka, Vitali B; Lee, Byeongdu; Shevchenko, Elena V
2015-02-01
To be able to control the functions of engineered multicomponent nanomaterials, a detailed understanding of heterogeneous nucleation at the nanoscale is essential. Here, by using in situ synchrotron X-ray scattering, we show that in the heterogeneous nucleation and growth of Au on Pt or Pt-alloy seeds the heteroepitaxial growth of the Au shell exerts high stress (∼2 GPa) on the seed by forming a core/shell structure in the early stage of the reaction. The development of lattice strain and subsequent strain relaxation, which we show using atomic-resolution transmission electron microscopy to occur through the slip of {111} layers, induces morphological changes from a core/shell to a dumbbell structure, and governs the nucleation and growth kinetics. We also propose a thermodynamic model for the nucleation and growth of dumbbell metallic heteronanostructures.
The Intermediate Energy Elastic Scattering of Protons by α-CLUSTER 20Ne and 24Mg Nuclei
NASA Astrophysics Data System (ADS)
Berezhnoy, Yu. A.; Mikhailyuk, V. P.; Pilipenko, V. V.
The multiple diffraction scattering theory and the α-cluster model with dispersion have been applied for calculations of the observables for the elastic scattering of intermediate energy protons by 20Ne and 24Mg nuclei. The target nuclei are considered as composed of the core (16O nucleus) and additional α-clusters (one α-cluster for 20Ne nucleus and a dumb-bell α-cluster configuration for 24Mg nucleus). Taking into account the α-cluster configuration of the core, it was supposed that the additional α-cluster or center of mass of the dumb-bell are arranged with the most probability inside or outside of the core. The calculated observables for the elastic p-20Ne and p-24Mg scattering are in agreement with the existing experimental data. The influence of the deformed core contribution on the behavior of the calculated observables also is tested.
NASA Astrophysics Data System (ADS)
Leoni, Stefano; Nesper, Reinhard
2003-01-01
A short topological pathway relating two fundamental three-dimensional, three-connected networks as they are found in α-ThSi 2 and SrSi 2 is proposed. The approach exploits a Fourier function approach based on periodic nodal (PNS) and periodic equi-surface (PES) descriptors. Continuous functions are chosen to represent the networks in question, and a linear transition approach provides a transition model. On this basis, each network is fragmented into a collection of dumb-bells, and the transition is described in terms of a concerted reorientation of the latter. The centers of mass of the dumb-bells are shown to conserve the diamond topology at each stage of the transition, as an underlying motif of the whole process.
Stochastic simulation of transport phenomena
Wedgewood, L.E.; Geurts, K.R.
1995-10-01
In this paper, four examples are given to demonstrate how stochastic simulations can be used as a method to obtain numerical solutions to transport problems. The problems considered are two-dimensional heat conduction, mass diffusion with reaction, the start-up of Poiseuille flow, and Couette flow of a suspension of Hookean dumbbells. The first three examples are standard problems with well-known analytic solutions which can be used to verify the results of the stochastic simulation. The fourth example combines a Brownian dynamics simulation for Hookean dumbbells, a crude model of a dilute polymer suspension, and a stochastic simulation for the suspending, Newtonian fluid. These examples illustrate appropriate methods for handling source/sink terms and initial and boundary conditions. The stochastic simulation results compare well with the analytic solutions and other numerical solutions. The goal of this paper is to demonstrate the wide applicability of stochastic simulation as a numerical method for transport problems.
Building Mental Models by Dissecting Physical Models
ERIC Educational Resources Information Center
Srivastava, Anveshna
2016-01-01
When students build physical models from prefabricated components to learn about model systems, there is an implicit trade-off between the physical degrees of freedom in building the model and the intensity of instructor supervision needed. Models that are too flexible, permitting multiple possible constructions require greater supervision to…
John A. Schroeder
2012-06-01
The Standardized Plant Analysis Risk (SPAR) models for the U.S. commercial nuclear power plants currently have very limited instrumentation and control (I&C) modeling [1]. Most of the I&C components in the operating plant SPAR models are related to the reactor protection system. This was identified as a finding during the industry peer review of SPAR models. While the Emergency Safeguard Features (ESF) actuation and control system was incorporated into the Peach Bottom Unit 2 SPAR model in a recent effort [2], various approaches to expend resources for detailed I&C modeling in other SPAR models are investigated.
Engineering Structurally Configurable Models with Model Transformation
2008-12-15
model in the case of Simulink, and a dataflow model in the case of LabVIEW). Research modeling tools such as Ptolemy II [14], ForSyDe [21], SPEX [30...functionality of our model transformation tool built in the Ptolemy II framework, and its application to large models of distributed and parallel embedded...in Ptolemy II, the same idea can be applied to other modeling tools such as Simulink, LabVIEW, ForSyDe, SPEX and ModHel’X. Moreover, the recent OMG
Longini, Ira M.; Morris, J. Glenn
2014-01-01
Mathematical modeling can be a valuable tool for studying infectious disease outbreak dynamics and simulating the effects of possible interventions. Here, we describe approaches to modeling cholera outbreaks and how models have been applied to explore intervention strategies, particularly in Haiti. Mathematical models can play an important role in formulating and evaluating complex cholera outbreak response options. Major challenges to cholera modeling are insufficient data for calibrating models and the need to tailor models for different outbreak scenarios. PMID:23412687
Air Quality Dispersion Modeling - Alternative Models
Models, not listed in Appendix W, that can be used in regulatory applications with case-by-case justification to the Reviewing Authority as noted in Section 3.2, Use of Alternative Models, in Appendix W.
Uncertainty Modeling Via Frequency Domain Model Validation
NASA Technical Reports Server (NTRS)
Waszak, Martin R.; Andrisani, Dominick, II
1999-01-01
Abstract The majority of literature on robust control assumes that a design model is available and that the uncertainty model bounds the actual variations about the nominal model. However, methods for generating accurate design models have not received as much attention in the literature. The influence of the level of accuracy of the uncertainty model on closed loop performance has received even less attention. The research reported herein is an initial step in applying and extending the concept of model validation to the problem of obtaining practical uncertainty models for robust control analysis and design applications. An extension of model validation called 'sequential validation' is presented and applied to a simple spring-mass-damper system to establish the feasibility of the approach and demonstrate the benefits of the new developments.
Li, Chunxiang; Qiu, Xiyang; Hou, Zhaohui; Deng, Keqin
2015-02-15
Highly sensitive detection of transcription factors (TF) is essential to proteome and genomics research as well as clinical diagnosis. We describe herein a novel fluorescent-amplified strategy for ultrasensitive, quantitative, and inexpensive detection of TF. The strategy consists of a hairpin DNA probe containing a TF binding sequence for target TF, a dumbbell-shaped probe, a primer DNA probe designed partly complementary to hairpin DNA probe, and a dumbbell probe. In the presence of target TF, the binding of the TF with hairpin DNA probe will prohibit the hybridization of the primer DNA probe with the "stem" and "loop" region of the hairpin DNA probe, then the unhybridized region of the primer DNA will hybridize with dumbbell probe, subsequently promote the ligation reaction and the rolling circle amplification (RCA), finally, the RCA products are quantified via the fluorescent intensity of SYBR Green I (SG). Using TATA-binding protein (TBP) as a model transcription factor, the proposed assay system can specifically detect TBP with a detection limit as low as 40.7 fM, and with a linear range from 100 fM to 1 nM. Moreover, this assay related DNA probe does not involve any modification and the whole assay proceeds in one tube, which makes the assay simple and low cost. It is expected to become a powerful tool for bioanalysis and clinic diagnostic application.
Habit modification of calcium carbonate in the presence of malic acid
Mao Zhaofeng; Huang Jianhua
2007-02-15
The ability of malic acid to control calcium carbonate morphology has been investigated by aging calcium chloride solution in the presence of urea in a 90 deg. C bath. Malic acid favors the formation of calcite. A transition from single block to aggregate with special morphology occurs upon increasing malic acid concentration. The morphological development of CaCO{sub 3} crystal obviously depends on the starting pH. CaCO{sub 3} crystal grows from spindle seed to dumbbell in the pH regime from 7 to 11; while it evolves from spindle seed, through peanut, to sphere at pH=11.5. Both dumbbell and sphere consist of rods that are elongated along c-axis and capped with three smooth, well-defined rhombic {l_brace}1 0 4{r_brace} faces. A tentative growth mechanism is proposed based on the fractal model suggested by R. Kniep and S. Busch [Angew. Chem. Int. Ed. Engl. 35 (1996) 2624]. - Graphical abstract: Dumbbell-like CaCO{sub 3} particles obtained in the presence of malic acid.
Model selection for logistic regression models
NASA Astrophysics Data System (ADS)
Duller, Christine
2012-09-01
Model selection for logistic regression models decides which of some given potential regressors have an effect and hence should be included in the final model. The second interesting question is whether a certain factor is heterogeneous among some subsets, i.e. whether the model should include a random intercept or not. In this paper these questions will be answered with classical as well as with Bayesian methods. The application show some results of recent research projects in medicine and business administration.
ERIC Educational Resources Information Center
Willden, Jeff
2001-01-01
"Bohr's Atomic Model" is a small interactive multimedia program that introduces the viewer to a simplified model of the atom. This interactive simulation lets students build an atom using an atomic construction set. The underlying design methodology for "Bohr's Atomic Model" is model-centered instruction, which means the central model of the…
Bohr model as an algebraic collective model
Rowe, D. J.; Welsh, T. A.; Caprio, M. A.
2009-05-15
Developments and applications are presented of an algebraic version of Bohr's collective model. Illustrative examples show that fully converged calculations can be performed quickly and easily for a large range of Hamiltonians. As a result, the Bohr model becomes an effective tool in the analysis of experimental data. The examples are chosen both to confirm the reliability of the algebraic collective model and to show the diversity of results that can be obtained by its use. The focus of the paper is to facilitate identification of the limitations of the Bohr model with a view to developing more realistic, computationally tractable models.
Building mental models by dissecting physical models.
Srivastava, Anveshna
2016-01-01
When students build physical models from prefabricated components to learn about model systems, there is an implicit trade-off between the physical degrees of freedom in building the model and the intensity of instructor supervision needed. Models that are too flexible, permitting multiple possible constructions require greater supervision to ensure focused learning; models that are too constrained require less supervision, but can be constructed mechanically, with little to no conceptual engagement. We propose "model-dissection" as an alternative to "model-building," whereby instructors could make efficient use of supervisory resources, while simultaneously promoting focused learning. We report empirical results from a study conducted with biology undergraduate students, where we demonstrate that asking them to "dissect" out specific conceptual structures from an already built 3D physical model leads to a significant improvement in performance than asking them to build the 3D model from simpler components. Using questionnaires to measure understanding both before and after model-based interventions for two cohorts of students, we find that both the "builders" and the "dissectors" improve in the post-test, but it is the latter group who show statistically significant improvement. These results, in addition to the intrinsic time-efficiency of "model dissection," suggest that it could be a valuable pedagogical tool.
Hyperbolic contraction measuring systems for extensional flow
NASA Astrophysics Data System (ADS)
Nyström, M.; Tamaddon Jahromi, H. R.; Stading, M.; Webster, M. F.
2017-02-01
In this paper an experimental method for extensional measurements on medium viscosity fluids in contraction flow is evaluated through numerical simulations and experimental measurements. This measuring technique measures the pressure drop over a hyperbolic contraction, caused by fluid extension and fluid shear, where the extensional component is assumed to dominate. The present evaluative work advances our previous studies on this experimental method by introducing several contraction ratios and addressing different constitutive models of varying shear and extensional response. The constitutive models included are those of the constant viscosity Oldroyd-B and FENE-CR models, and the shear-thinning LPTT model. Examining the results, the impact of shear and first normal stress difference on the measured pressure drop are studied through numerical pressure drop predictions. In addition, stream function patterns are investigated to detect vortex development and influence of contraction ratio. The numerical predictions are further related to experimental measurements for the flow through a 15:1 contraction ratio with three different test fluids. The measured pressure drops are observed to exhibit the same trends as predicted in the numerical simulations, offering close correlation and tight predictive windows for experimental data capture. This result has demonstrated that the hyperbolic contraction flow is well able to detect such elastic fluid properties and that this is matched by numerical predictions in evaluation of their flow response. The hyperbolical contraction flow technique is commended for its distinct benefits: it is straightforward and simple to perform, the Hencky strain can be set by changing contraction ratio, non-homogeneous fluids can be tested, and one can directly determine the degree of elastic fluid behaviour. Based on matching of viscometric extensional viscosity response for FENE-CR and LPTT models, a decline is predicted in pressure drop for
Geologic Framework Model Analysis Model Report
R. Clayton
2000-12-19
The purpose of this report is to document the Geologic Framework Model (GFM), Version 3.1 (GFM3.1) with regard to data input, modeling methods, assumptions, uncertainties, limitations, and validation of the model results, qualification status of the model, and the differences between Version 3.1 and previous versions. The GFM represents a three-dimensional interpretation of the stratigraphy and structural features of the location of the potential Yucca Mountain radioactive waste repository. The GFM encompasses an area of 65 square miles (170 square kilometers) and a volume of 185 cubic miles (771 cubic kilometers). The boundaries of the GFM were chosen to encompass the most widely distributed set of exploratory boreholes (the Water Table or WT series) and to provide a geologic framework over the area of interest for hydrologic flow and radionuclide transport modeling through the unsaturated zone (UZ). The depth of the model is constrained by the inferred depth of the Tertiary-Paleozoic unconformity. The GFM was constructed from geologic map and borehole data. Additional information from measured stratigraphy sections, gravity profiles, and seismic profiles was also considered. This interim change notice (ICN) was prepared in accordance with the Technical Work Plan for the Integrated Site Model Process Model Report Revision 01 (CRWMS M&O 2000). The constraints, caveats, and limitations associated with this model are discussed in the appropriate text sections that follow. The GFM is one component of the Integrated Site Model (ISM) (Figure l), which has been developed to provide a consistent volumetric portrayal of the rock layers, rock properties, and mineralogy of the Yucca Mountain site. The ISM consists of three components: (1) Geologic Framework Model (GFM); (2) Rock Properties Model (RPM); and (3) Mineralogic Model (MM). The ISM merges the detailed project stratigraphy into model stratigraphic units that are most useful for the primary downstream models and the
Photochemical Modeling Applications
Provides access to modeling applications involving photochemical models, including modeling of ozone, particulate matter (PM), and mercury for national and regional EPA regulations such as the Clean Air Interstate Rule (CAIR) and the Clean Air Mercury Rule
Educating with Aircraft Models
ERIC Educational Resources Information Center
Steele, Hobie
1976-01-01
Described is utilization of aircraft models, model aircraft clubs, and model aircraft magazines to promote student interest in aerospace education. The addresses for clubs and magazines are included. (SL)
NASA Technical Reports Server (NTRS)
Liou, J. C.
2012-01-01
Presentation outlne: (1) The NASA Orbital Debris (OD) Engineering Model -- A mathematical model capable of predicting OD impact risks for the ISS and other critical space assets (2) The NASA OD Evolutionary Model -- A physical model capable of predicting future debris environment based on user-specified scenarios (3) The NASA Standard Satellite Breakup Model -- A model describing the outcome of a satellite breakup (explosion or collision)
NASA Technical Reports Server (NTRS)
Cellier, Francois E.
1991-01-01
A comprehensive and systematic introduction is presented for the concepts associated with 'modeling', involving the transition from a physical system down to an abstract description of that system in the form of a set of differential and/or difference equations, and basing its treatment of modeling on the mathematics of dynamical systems. Attention is given to the principles of passive electrical circuit modeling, planar mechanical systems modeling, hierarchical modular modeling of continuous systems, and bond-graph modeling. Also discussed are modeling in equilibrium thermodynamics, population dynamics, and system dynamics, inductive reasoning, artificial neural networks, and automated model synthesis.
Regularized Structural Equation Modeling.
Jacobucci, Ross; Grimm, Kevin J; McArdle, John J
A new method is proposed that extends the use of regularization in both lasso and ridge regression to structural equation models. The method is termed regularized structural equation modeling (RegSEM). RegSEM penalizes specific parameters in structural equation models, with the goal of creating easier to understand and simpler models. Although regularization has gained wide adoption in regression, very little has transferred to models with latent variables. By adding penalties to specific parameters in a structural equation model, researchers have a high level of flexibility in reducing model complexity, overcoming poor fitting models, and the creation of models that are more likely to generalize to new samples. The proposed method was evaluated through a simulation study, two illustrative examples involving a measurement model, and one empirical example involving the structural part of the model to demonstrate RegSEM's utility.
ROCK PROPERTIES MODEL ANALYSIS MODEL REPORT
Clinton Lum
2002-02-04
The purpose of this Analysis and Model Report (AMR) is to document Rock Properties Model (RPM) 3.1 with regard to input data, model methods, assumptions, uncertainties and limitations of model results, and qualification status of the model. The report also documents the differences between the current and previous versions and validation of the model. The rock properties models are intended principally for use as input to numerical physical-process modeling, such as of ground-water flow and/or radionuclide transport. The constraints, caveats, and limitations associated with this model are discussed in the appropriate text sections that follow. This work was conducted in accordance with the following planning documents: WA-0344, ''3-D Rock Properties Modeling for FY 1998'' (SNL 1997, WA-0358), ''3-D Rock Properties Modeling for FY 1999'' (SNL 1999), and the technical development plan, Rock Properties Model Version 3.1, (CRWMS M&O 1999c). The Interim Change Notice (ICNs), ICN 02 and ICN 03, of this AMR were prepared as part of activities being conducted under the Technical Work Plan, TWP-NBS-GS-000003, ''Technical Work Plan for the Integrated Site Model, Process Model Report, Revision 01'' (CRWMS M&O 2000b). The purpose of ICN 03 is to record changes in data input status due to data qualification and verification activities. These work plans describe the scope, objectives, tasks, methodology, and implementing procedures for model construction. The constraints, caveats, and limitations associated with this model are discussed in the appropriate text sections that follow. The work scope for this activity consists of the following: (1) Conversion of the input data (laboratory measured porosity data, x-ray diffraction mineralogy, petrophysical calculations of bound water, and petrophysical calculations of porosity) for each borehole into stratigraphic coordinates; (2) Re-sampling and merging of data sets; (3) Development of geostatistical simulations of porosity; (4
Model Reduction of Viscoelastic Finite Element Models
NASA Astrophysics Data System (ADS)
Park, C. H.; Inman, D. J.; Lam, M. J.
1999-01-01
This paper examines a method of adding viscoelastic properties to finite element models by using additional co-ordinates to account for the frequency dependence usually associated with such damping materials. Several such methods exist and all suffer from an increase in order of the final finite model which is undesirable in many applications. Here we propose to combine one of these methods, the GHM (Golla-Hughes-McTavish) method, with model reduction techniques to remove the objection of increased model order. The result of combining several methods is an ability to add the effects of visoelastic components to finite element or other analytical models without increasing the order of the system. The procedure is illustrated by a numerical example. The method proposed here results in a viscoelastic finite element of a structure without increasing the order of the original model.
Neurometric Modeling: Computational Modeling of Individual Brains
2011-05-16
Army Research Office P.O. Box 12211 Research Triangle Park, NC 27709-2211 15. SUBJECT TERMS Neural networks, computational neuroscience, fMRI ...obtained using functional MRI. Algorithmic processing of these measurements can exploit a variety of statistical machine learning methods to... statistical machine learning methods to synthesize a new kind of neuro-cognitive model, which we call neurometric models. These executable models could be
Better models are more effectively connected models
NASA Astrophysics Data System (ADS)
Nunes, João Pedro; Bielders, Charles; Darboux, Frederic; Fiener, Peter; Finger, David; Turnbull-Lloyd, Laura; Wainwright, John
2016-04-01
The concept of hydrologic and geomorphologic connectivity describes the processes and pathways which link sources (e.g. rainfall, snow and ice melt, springs, eroded areas and barren lands) to accumulation areas (e.g. foot slopes, streams, aquifers, reservoirs), and the spatial variations thereof. There are many examples of hydrological and sediment connectivity on a watershed scale; in consequence, a process-based understanding of connectivity is crucial to help managers understand their systems and adopt adequate measures for flood prevention, pollution mitigation and soil protection, among others. Modelling is often used as a tool to understand and predict fluxes within a catchment by complementing observations with model results. Catchment models should therefore be able to reproduce the linkages, and thus the connectivity of water and sediment fluxes within the systems under simulation. In modelling, a high level of spatial and temporal detail is desirable to ensure taking into account a maximum number of components, which then enables connectivity to emerge from the simulated structures and functions. However, computational constraints and, in many cases, lack of data prevent the representation of all relevant processes and spatial/temporal variability in most models. In most cases, therefore, the level of detail selected for modelling is too coarse to represent the system in a way in which connectivity can emerge; a problem which can be circumvented by representing fine-scale structures and processes within coarser scale models using a variety of approaches. This poster focuses on the results of ongoing discussions on modelling connectivity held during several workshops within COST Action Connecteur. It assesses the current state of the art of incorporating the concept of connectivity in hydrological and sediment models, as well as the attitudes of modellers towards this issue. The discussion will focus on the different approaches through which connectivity
M. A. Wasiolek
2003-10-27
The purpose of this report is to document the biosphere model, the Environmental Radiation Model for Yucca Mountain, Nevada (ERMYN), which describes radionuclide transport processes in the biosphere and associated human exposure that may arise as the result of radionuclide release from the geologic repository at Yucca Mountain. The biosphere model is one of the process models that support the Yucca Mountain Project (YMP) Total System Performance Assessment (TSPA) for the license application (LA), the TSPA-LA. The ERMYN model provides the capability of performing human radiation dose assessments. This report documents the biosphere model, which includes: (1) Describing the reference biosphere, human receptor, exposure scenarios, and primary radionuclides for each exposure scenario (Section 6.1); (2) Developing a biosphere conceptual model using site-specific features, events, and processes (FEPs), the reference biosphere, the human receptor, and assumptions (Section 6.2 and Section 6.3); (3) Building a mathematical model using the biosphere conceptual model and published biosphere models (Sections 6.4 and 6.5); (4) Summarizing input parameters for the mathematical model, including the uncertainty associated with input values (Section 6.6); (5) Identifying improvements in the ERMYN model compared with the model used in previous biosphere modeling (Section 6.7); (6) Constructing an ERMYN implementation tool (model) based on the biosphere mathematical model using GoldSim stochastic simulation software (Sections 6.8 and 6.9); (7) Verifying the ERMYN model by comparing output from the software with hand calculations to ensure that the GoldSim implementation is correct (Section 6.10); and (8) Validating the ERMYN model by corroborating it with published biosphere models; comparing conceptual models, mathematical models, and numerical results (Section 7).
D. W. Wu
2003-07-16
The purpose of this report is to document the biosphere model, the Environmental Radiation Model for Yucca Mountain, Nevada (ERMYN), which describes radionuclide transport processes in the biosphere and associated human exposure that may arise as the result of radionuclide release from the geologic repository at Yucca Mountain. The biosphere model is one of the process models that support the Yucca Mountain Project (YMP) Total System Performance Assessment (TSPA) for the license application (LA), the TSPA-LA. The ERMYN model provides the capability of performing human radiation dose assessments. This report documents the biosphere model, which includes: (1) Describing the reference biosphere, human receptor, exposure scenarios, and primary radionuclides for each exposure scenario (Section 6.1); (2) Developing a biosphere conceptual model using site-specific features, events, and processes (FEPs), the reference biosphere, the human receptor, and assumptions (Section 6.2 and Section 6.3); (3) Building a mathematical model using the biosphere conceptual model and published biosphere models (Sections 6.4 and 6.5); (4) Summarizing input parameters for the mathematical model, including the uncertainty associated with input values (Section 6.6); (5) Identifying improvements in the ERMYN model compared with the model used in previous biosphere modeling (Section 6.7); (6) Constructing an ERMYN implementation tool (model) based on the biosphere mathematical model using GoldSim stochastic simulation software (Sections 6.8 and 6.9); (7) Verifying the ERMYN model by comparing output from the software with hand calculations to ensure that the GoldSim implementation is correct (Section 6.10); and (8) Validating the ERMYN model by corroborating it with published biosphere models; comparing conceptual models, mathematical models, and numerical results (Section 7).
ERIC Educational Resources Information Center
Clancey, William J.
The concept of a qualitative model is used as the focus of this review of qualitative student models in order to compare alternative computational models and to contrast domain requirements. The report is divided into eight sections: (1) Origins and Goals (adaptive instruction, qualitative models of processes, components of an artificial…
Models for Ammunition Management
1977-08-01
Analysis Operations Research Management Models Mobilization Planning Computer Programming Ammunition Management Economic Analysis Production Planning...ammunition managers on a unique set of nine modern computer models specifically developed to support the conventional ammunition management decision...DECISION MODELS DIRECTORATE ROCK ISLAND, ILLINOIS 61201 r ABSTRACT This special management report presents a unique set of nine computer models
Generative Models of Disfluency
ERIC Educational Resources Information Center
Miller, Timothy A.
2010-01-01
This thesis describes a generative model for representing disfluent phenomena in human speech. This model makes use of observed syntactic structure present in disfluent speech, and uses a right-corner transform on syntax trees to model this structure in a very natural way. Specifically, the phenomenon of speech repair is modeled by explicitly…
Multimodeling and Model Abstraction
Technology Transfer Automated Retrieval System (TEKTRAN)
The multiplicity of models of the same process or phenomenon is the commonplace in environmental modeling. Last 10 years brought marked interest to making use of the variety of conceptual approaches instead of attempting to find the best model or using a single preferred model. Two systematic approa...
2015-09-01
The Biomass Scenario Model (BSM) is a unique, carefully validated, state-of-the-art dynamic model of the domestic biofuels supply chain which explicitly focuses on policy issues, their feasibility, and potential side effects. It integrates resource availability, physical/technological/economic constraints, behavior, and policy. The model uses a system dynamics simulation (not optimization) to model dynamic interactions across the supply chain.
ERIC Educational Resources Information Center
Yeates, Devin Rodney
2011-01-01
The goal of this dissertation is to enable better predictive models by engaging raw experimental data through the Instrumental Model. The Instrumental Model captures the protocols and procedures of experimental data analysis. The approach is formalized by encoding the Instrumental Model in an XML record. Decoupling the raw experimental data from…
NASA Astrophysics Data System (ADS)
Rahmani, Fouad Lazhar
2010-11-01
The aim of this paper is to present mathematical modelling of the spread of infection in the context of the transmission of the human immunodeficiency virus (HIV) and the acquired immune deficiency syndrome (AIDS). These models are based in part on the models suggested in the field of th AIDS mathematical modelling as reported by ISHAM [6].
Solid-fluid equilibrium of fused-hard-sphere systems: Free-volume theories and simulation
NASA Astrophysics Data System (ADS)
Gay, Shawn Christian
Historically, the theoretical investigation of solid-fluid phase equilibrium has largely focused on the freezing of hard spheres. Only relatively recently have theories begun to address the phase equilibria of systems of nonspherical molecules. This thesis details the application of various theoretical methods to predict the solid-fluid phase equilibria of systems of nonspherical molecules. The general approach is to first calculate the properties of systems of fused-hard-sphere molecules, and then model real systems by extending the fused-hard-sphere results using generalized van der Waals theory and perturbation theory to describe the effects of longer range interactions. Results of original research are presented that demonstrate the effectiveness of the theories, often by direct comparison with Monte Carlo simulation results and, where applicable, by comparison with experiment. We use a simple cell theory to calculate the free energy of the heteronuclear hard-dumbbell solid and an analytic equation of state to calculate the free energy of the fluid. Decreasing the ratio of the diameters of the spheres composing the dumbbell is found to increase the pressure at freezing. We have also calculated the distribution of free volumes in the solid phase of two-dimensional hard dumbbells. This information allows us to characterize a fluctuating cell theory as well as new statistical geometry relations for fused-hard-sphere systems presented in this thesis. Finally, we use simple cell theory results for hard dumbbells in a generalized van der Waals theory to calculate the solid-liquid phase transition for a system of dipolar hard dumbbells. Our model is chosen to approximate a methyl chloride molecule. Thermodynamic perturbation theory is used to include dipolar effects in the fluid equation of state, and static-lattice sums are used to approximate dipolar effects in the solid phase. We find that the presence of a dipole moment stabilizes a non-closepacking crystal
NASA Astrophysics Data System (ADS)
Luczak, Joshua
2017-02-01
Scientific models are frequently discussed in philosophy of science. A great deal of the discussion is centred on approximation, idealisation, and on how these models achieve their representational function. Despite the importance, distinct nature, and high presence of toy models, they have received little attention from philosophers. This paper hopes to remedy this situation. It aims to elevate the status of toy models: by distinguishing them from approximations and idealisations, by highlighting and elaborating on several ways the Kac ring, a simple statistical mechanical model, is used as a toy model, and by explaining why toy models can be used to successfully carry out important work without performing a representational function.
Molenaar, Peter C M
2017-02-16
Equivalences of two classes of dynamic models for weakly stationary multivariate time series are discussed: dynamic factor models and autoregressive models. It is shown that exploratory dynamic factor models can be rotated, yielding an infinite set of equivalent solutions for any observed series. It also is shown that dynamic factor models with lagged factor loadings are not equivalent to the currently popular state-space models, and that restriction of attention to the latter type of models may yield invalid results. The known equivalent vector autoregressive model types, standard and structural, are given a new interpretation in which they are conceived of as the extremes of an innovating type of hybrid vector autoregressive models. It is shown that consideration of hybrid models solves many problems, in particular with Granger causality testing.
Knowledge and information modeling.
Madsen, Maria
2010-01-01
This chapter gives an educational overview of: * commonly used modelling methods what they represent * the importance of selecting the tools and methods suited to the health information system being designed * how the quality of the information or knowledge model is determined by the quality of the system requirements specification * differentiating between the purpose of information models and knowledge models * the benefits of the openEHR approach for health care data modeling.
Introduction to Adjoint Models
NASA Technical Reports Server (NTRS)
Errico, Ronald M.
2015-01-01
In this lecture, some fundamentals of adjoint models will be described. This includes a basic derivation of tangent linear and corresponding adjoint models from a parent nonlinear model, the interpretation of adjoint-derived sensitivity fields, a description of methods of automatic differentiation, and the use of adjoint models to solve various optimization problems, including singular vectors. Concluding remarks will attempt to correct common misconceptions about adjoint models and their utilization.
Stable models of superacceleration
Kaplinghat, Manoj; Rajaraman, Arvind
2007-05-15
We discuss an instability in a large class of models where dark energy is coupled to matter. In these models the mass of the scalar field is much larger than the expansion rate of the Universe. We find models in which this instability is absent, and show that these models generically predict an apparent equation of state for dark energy smaller than -1, i.e., superacceleration. These models have no acausal behavior or ghosts.
WASP TRANSPORT MODELING AND WASP ECOLOGICAL MODELING
A combination of lectures, demonstrations, and hands-on excercises will be used to introduce pollutant transport modeling with the U.S. EPA's general water quality model, WASP (Water Quality Analysis Simulation Program). WASP features include a user-friendly Windows-based interfa...
Model Shrinkage for Discriminative Language Models
NASA Astrophysics Data System (ADS)
Oba, Takanobu; Hori, Takaaki; Nakamura, Atsushi; Ito, Akinori
This paper describes a technique for overcoming the model shrinkage problem in automatic speech recognition (ASR), which allows application developers and users to control the model size with less degradation of accuracy. Recently, models for ASR systems tend to be large and this can constitute a bottleneck for developers and users without special knowledge of ASR with respect to introducing the ASR function. Specifically, discriminative language models (DLMs) are usually designed in a high-dimensional parameter space, although DLMs have gained increasing attention as an approach for improving recognition accuracy. Our proposed method can be applied to linear models including DLMs, in which the score of an input sample is given by the inner product of its features and the model parameters, but our proposed method can shrink models in an easy computation by obtaining simple statistics, which are square sums of feature values appearing in a data set. Our experimental results show that our proposed method can shrink a DLM with little degradation in accuracy and perform properly whether or not the data for obtaining the statistics are the same as the data for training the model.
Geochemistry Model Validation Report: External Accumulation Model
K. Zarrabi
2001-09-27
The purpose of this Analysis and Modeling Report (AMR) is to validate the External Accumulation Model that predicts accumulation of fissile materials in fractures and lithophysae in the rock beneath a degrading waste package (WP) in the potential monitored geologic repository at Yucca Mountain. (Lithophysae are voids in the rock having concentric shells of finely crystalline alkali feldspar, quartz, and other materials that were formed due to entrapped gas that later escaped, DOE 1998, p. A-25.) The intended use of this model is to estimate the quantities of external accumulation of fissile material for use in external criticality risk assessments for different types of degrading WPs: U.S. Department of Energy (DOE) Spent Nuclear Fuel (SNF) codisposed with High Level Waste (HLW) glass, commercial SNF, and Immobilized Plutonium Ceramic (Pu-ceramic) codisposed with HLW glass. The scope of the model validation is to (1) describe the model and the parameters used to develop the model, (2) provide rationale for selection of the parameters by comparisons with measured values, and (3) demonstrate that the parameters chosen are the most conservative selection for external criticality risk calculations. To demonstrate the applicability of the model, a Pu-ceramic WP is used as an example. The model begins with a source term from separately documented EQ6 calculations; where the source term is defined as the composition versus time of the water flowing out of a breached waste package (WP). Next, PHREEQC, is used to simulate the transport and interaction of the source term with the resident water and fractured tuff below the repository. In these simulations the primary mechanism for accumulation is mixing of the high pH, actinide-laden source term with resident water; thus lowering the pH values sufficiently for fissile minerals to become insoluble and precipitate. In the final section of the model, the outputs from PHREEQC, are processed to produce mass of accumulation
Model Validation Status Review
E.L. Hardin
2001-11-28
The primary objective for the Model Validation Status Review was to perform a one-time evaluation of model validation associated with the analysis/model reports (AMRs) containing model input to total-system performance assessment (TSPA) for the Yucca Mountain site recommendation (SR). This review was performed in response to Corrective Action Request BSC-01-C-01 (Clark 2001, Krisha 2001) pursuant to Quality Assurance review findings of an adverse trend in model validation deficiency. The review findings in this report provide the following information which defines the extent of model validation deficiency and the corrective action needed: (1) AMRs that contain or support models are identified, and conversely, for each model the supporting documentation is identified. (2) The use for each model is determined based on whether the output is used directly for TSPA-SR, or for screening (exclusion) of features, events, and processes (FEPs), and the nature of the model output. (3) Two approaches are used to evaluate the extent to which the validation for each model is compliant with AP-3.10Q (Analyses and Models). The approaches differ in regard to whether model validation is achieved within individual AMRs as originally intended, or whether model validation could be readily achieved by incorporating information from other sources. (4) Recommendations are presented for changes to the AMRs, and additional model development activities or data collection, that will remedy model validation review findings, in support of licensing activities. The Model Validation Status Review emphasized those AMRs that support TSPA-SR (CRWMS M&O 2000bl and 2000bm). A series of workshops and teleconferences was held to discuss and integrate the review findings. The review encompassed 125 AMRs (Table 1) plus certain other supporting documents and data needed to assess model validity. The AMRs were grouped in 21 model areas representing the modeling of processes affecting the natural and
Trapped Radiation Model Uncertainties: Model-Data and Model-Model Comparisons
NASA Technical Reports Server (NTRS)
Armstrong, T. W.; Colborn, B. L.
2000-01-01
The standard AP8 and AE8 models for predicting trapped proton and electron environments have been compared with several sets of flight data to evaluate model uncertainties. Model comparisons are made with flux and dose measurements made on various U.S. low-Earth orbit satellites (APEX, CRRES, DMSP, LDEF, NOAA) and Space Shuttle flights, on Russian satellites (Photon-8, Cosmos-1887, Cosmos-2044), and on the Russian Mir Space Station. This report gives the details of the model-data comparisons-summary results in terms of empirical model uncertainty factors that can be applied for spacecraft design applications are given in a combination report. The results of model-model comparisons are also presented from standard AP8 and AE8 model predictions compared with the European Space Agency versions of AP8 and AE8 and with Russian-trapped radiation models.
Trapped Radiation Model Uncertainties: Model-Data and Model-Model Comparisons
NASA Technical Reports Server (NTRS)
Armstrong, T. W.; Colborn, B. L.
2000-01-01
The standard AP8 and AE8 models for predicting trapped proton and electron environments have been compared with several sets of flight data to evaluate model uncertainties. Model comparisons are made with flux and dose measurements made on various U.S. low-Earth orbit satellites (APEX, CRRES, DMSP. LDEF, NOAA) and Space Shuttle flights, on Russian satellites (Photon-8, Cosmos-1887, Cosmos-2044), and on the Russian Mir space station. This report gives the details of the model-data comparisons -- summary results in terms of empirical model uncertainty factors that can be applied for spacecraft design applications are given in a companion report. The results of model-model comparisons are also presented from standard AP8 and AE8 model predictions compared with the European Space Agency versions of AP8 and AE8 and with Russian trapped radiation models.
Swiler, Laura Painton; Urbina, Angel
2010-07-01
This paper compares three approaches for model selection: classical least squares methods, information theoretic criteria, and Bayesian approaches. Least squares methods are not model selection methods although one can select the model that yields the smallest sum-of-squared error function. Information theoretic approaches balance overfitting with model accuracy by incorporating terms that penalize more parameters with a log-likelihood term to reflect goodness of fit. Bayesian model selection involves calculating the posterior probability that each model is correct, given experimental data and prior probabilities that each model is correct. As part of this calculation, one often calibrates the parameters of each model and this is included in the Bayesian calculations. Our approach is demonstrated on a structural dynamics example with models for energy dissipation and peak force across a bolted joint. The three approaches are compared and the influence of the log-likelihood term in all approaches is discussed.
Modeling nonstationary longitudinal data.
Núñez-Antón, V; Zimmerman, D L
2000-09-01
An important theme of longitudinal data analysis in the past two decades has been the development and use of explicit parametric models for the data's variance-covariance structure. A variety of these models have been proposed, of which most are second-order stationary. A few are flexible enough to accommodate nonstationarity, i.e., nonconstant variances and/or correlations that are not a function solely of elapsed time between measurements. We review five nonstationary models that we regard as most useful: (1) the unstructured covariance model, (2) unstructured antedependence models, (3) structured antedependence models, (4) autoregressive integrated moving average and similar models, and (5) random coefficients models. We evaluate the relative strengths and limitations of each model, emphasizing when it is inappropriate or unlikely to be useful. We present three examples to illustrate the fitting and comparison of the models and to demonstrate that nonstationary longitudinal data can be modeled effectively and, in some cases, quite parsimoniously. In these examples, the antedependence models generally prove to be superior and the random coefficients models prove to be inferior. We conclude that antedependence models should be given much greater consideration than they have historically received.
Modeling volatility using state space models.
Timmer, J; Weigend, A S
1997-08-01
In time series problems, noise can be divided into two categories: dynamic noise which drives the process, and observational noise which is added in the measurement process, but does not influence future values of the system. In this framework, we show that empirical volatilities (the squared relative returns of prices) exhibit a significant amount of observational noise. To model and predict their time evolution adequately, we estimate state space models that explicitly include observational noise. We obtain relaxation times for shocks in the logarithm of volatility ranging from three weeks (for foreign exchange) to three to five months (for stock indices). In most cases, a two-dimensional hidden state is required to yield residuals that are consistent with white noise. We compare these results with ordinary autoregressive models (without a hidden state) and find that autoregressive models underestimate the relaxation times by about two orders of magnitude since they do not distinguish between observational and dynamic noise. This new interpretation of the dynamics of volatility in terms of relaxators in a state space model carries over to stochastic volatility models and to GARCH models, and is useful for several problems in finance, including risk management and the pricing of derivative securities. Data sets used: Olsen & Associates high frequency DEM/USD foreign exchange rates (8 years). Nikkei 225 index (40 years). Dow Jones Industrial Average (25 years).
Posselt, Matthias; Gao, Fei; Bracht, Hartmut
2008-07-01
The migration of point defects in silicon and the corresponding atomic mobility are investigated by classical molecular dynamics simulations using the Stillinger-Weber potential and the Tersoff potential. In contrast to most of the previous studies both the point defect diffusivity and the self-diffusion coefficient per defect are calculated separately so that the diffusion-correlation factor can be determined. Simulations with both the Stillinger-Weber and the Tersoff potential show that vacancy migration is characterized by the transformation of the tetrahedral vacancy to the split vacancy and vice versa and the diffusion-correlation factor is about 0.5. This value was also derived by the statistical diffusion theory under the assumption of the same migration mechanism. The mechanisms of self-interstitial migration are more complex. The detailed study, including a visual analysis and investigations with the nudged elastic band method, reveals a variety of transformations between different self-interstitial configurations. Molecular dynamics simulations using the Stillinger-Weber potential show, that the self-interstitial migration is dominated by a dumbbell mechanism, whereas the interstitialcy mechanism prevails with the Tersoff potental. The corresponding values of the correlation factor are different, namely 0.59 and 0.69 for the dumbbell and the interstitialcy mechanism, respectively. The latter value is nearly equal to that obtained by the statistical theory which assumes the interstitialcy mechanism. Recent analysis of experimental results demonstrated, that in the framework of state-of-the-art diffusion and reaction models the best interpretation of point defect data can be given by assuming . The comparison with the present atomistic study leads to the conclusion that a dumbbell mechanism governs the self-interstitial migration in Si. Simulations using the Stillinger-Weber potential reveal two dominating migration paths which are characterized by
NASA Technical Reports Server (NTRS)
McMann, Catherine M. (Inventor); Cohen, Gerald C. (Inventor)
1991-01-01
An improved method and system for automatically generating reliability models for use with a reliability evaluation tool is described. The reliability model generator of the present invention includes means for storing a plurality of low level reliability models which represent the reliability characteristics for low level system components. In addition, the present invention includes means for defining the interconnection of the low level reliability models via a system architecture description. In accordance with the principles of the present invention, a reliability model for the entire system is automatically generated by aggregating the low level reliability models based on the system architecture description.
Reiter, E.R.
1980-01-01
A highly sophisticated and accurate approach is described to compute on an hourly or daily basis the energy consumption for space heating by individual buildings, urban sectors, and whole cities. The need for models and specifically weather-sensitive models, composite models, and space-heating models are discussed. Development of the Colorado State University Model, based on heat-transfer equations and on a heuristic, adaptive, self-organizing computation learning approach, is described. Results of modeling energy consumption by the city of Minneapolis and Cheyenne are given. Some data on energy consumption in individual buildings are included.
Modeling Guru: Knowledge Base for NASA Modelers
NASA Astrophysics Data System (ADS)
Seablom, M. S.; Wojcik, G. S.; van Aartsen, B. H.
2009-05-01
Modeling Guru is an on-line knowledge-sharing resource for anyone involved with or interested in NASA's scientific models or High End Computing (HEC) systems. Developed and maintained by the NASA's Software Integration and Visualization Office (SIVO) and the NASA Center for Computational Sciences (NCCS), Modeling Guru's combined forums and knowledge base for research and collaboration is becoming a repository for the accumulated expertise of NASA's scientific modeling and HEC communities. All NASA modelers and associates are encouraged to participate and provide knowledge about the models and systems so that other users may benefit from their experience. Modeling Guru is divided into a hierarchy of communities, each with its own set forums and knowledge base documents. Current modeling communities include those for space science, land and atmospheric dynamics, atmospheric chemistry, and oceanography. In addition, there are communities focused on NCCS systems, HEC tools and libraries, and programming and scripting languages. Anyone may view most of the content on Modeling Guru (available at http://modelingguru.nasa.gov/), but you must log in to post messages and subscribe to community postings. The site offers a full range of "Web 2.0" features, including discussion forums, "wiki" document generation, document uploading, RSS feeds, search tools, blogs, email notification, and "breadcrumb" links. A discussion (a.k.a. forum "thread") is used to post comments, solicit feedback, or ask questions. If marked as a question, SIVO will monitor the thread, and normally respond within a day. Discussions can include embedded images, tables, and formatting through the use of the Rich Text Editor. Also, the user can add "Tags" to their thread to facilitate later searches. The "knowledge base" is comprised of documents that are used to capture and share expertise with others. The default "wiki" document lets users edit within the browser so others can easily collaborate on the
A future of the model organism model
Rine, Jasper
2014-01-01
Changes in technology are fundamentally reframing our concept of what constitutes a model organism. Nevertheless, research advances in the more traditional model organisms have enabled fresh and exciting opportunities for young scientists to establish new careers and offer the hope of comprehensive understanding of fundamental processes in life. New advances in translational research can be expected to heighten the importance of basic research in model organisms and expand opportunities. However, researchers must take special care and implement new resources to enable the newest members of the community to engage fully with the remarkable legacy of information in these fields. PMID:24577733
D.W. Wu; A.J. Smith
2004-11-08
The purpose of this report is to document the biosphere model, the Environmental Radiation Model for Yucca Mountain, Nevada (ERMYN), which describes radionuclide transport processes in the biosphere and associated human exposure that may arise as the result of radionuclide release from the geologic repository at Yucca Mountain. The biosphere model is one of the process models that support the Yucca Mountain Project (YMP) Total System Performance Assessment (TSPA) for the license application (LA), TSPA-LA. The ERMYN provides the capability of performing human radiation dose assessments. This report documents the biosphere model, which includes: (1) Describing the reference biosphere, human receptor, exposure scenarios, and primary radionuclides for each exposure scenario (Section 6.1); (2) Developing a biosphere conceptual model using site-specific features, events, and processes (FEPs) (Section 6.2), the reference biosphere (Section 6.1.1), the human receptor (Section 6.1.2), and approximations (Sections 6.3.1.4 and 6.3.2.4); (3) Building a mathematical model using the biosphere conceptual model (Section 6.3) and published biosphere models (Sections 6.4 and 6.5); (4) Summarizing input parameters for the mathematical model, including the uncertainty associated with input values (Section 6.6); (5) Identifying improvements in the ERMYN compared with the model used in previous biosphere modeling (Section 6.7); (6) Constructing an ERMYN implementation tool (model) based on the biosphere mathematical model using GoldSim stochastic simulation software (Sections 6.8 and 6.9); (7) Verifying the ERMYN by comparing output from the software with hand calculations to ensure that the GoldSim implementation is correct (Section 6.10); (8) Validating the ERMYN by corroborating it with published biosphere models; comparing conceptual models, mathematical models, and numerical results (Section 7).
NASA Technical Reports Server (NTRS)
Ensey, Tyler S.
2013-01-01
During my internship at NASA, I was a model developer for Ground Support Equipment (GSE). The purpose of a model developer is to develop and unit test model component libraries (fluid, electrical, gas, etc.). The models are designed to simulate software for GSE (Ground Special Power, Crew Access Arm, Cryo, Fire and Leak Detection System, Environmental Control System (ECS), etc. .) before they are implemented into hardware. These models support verifying local control and remote software for End-Item Software Under Test (SUT). The model simulates the physical behavior (function, state, limits and 110) of each end-item and it's dependencies as defined in the Subsystem Interface Table, Software Requirements & Design Specification (SRDS), Ground Integrated Schematic (GIS), and System Mechanical Schematic.(SMS). The software of each specific model component is simulated through MATLAB's Simulink program. The intensiv model development life cycle is a.s follows: Identify source documents; identify model scope; update schedule; preliminary design review; develop model requirements; update model.. scope; update schedule; detailed design review; create/modify library component; implement library components reference; implement subsystem components; develop a test script; run the test script; develop users guide; send model out for peer review; the model is sent out for verifictionlvalidation; if there is empirical data, a validation data package is generated; if there is not empirical data, a verification package is generated; the test results are then reviewed; and finally, the user. requests accreditation, and a statement of accreditation is prepared. Once each component model is reviewed and approved, they are intertwined together into one integrated model. This integrated model is then tested itself, through a test script and autotest, so that it can be concluded that all models work conjointly, for a single purpose. The component I was assigned, specifically, was a
NASA Astrophysics Data System (ADS)
Horiuti, Kiyosi; Suzuki, Shu
2014-11-01
We study the elongation process of polymers released in the Newtonian homogeneous isotropic turbulence by connecting a mesoscopic description of ensemble of elastic dumbbells using Brownian dynamics (BDS) to the macroscopic description for the fluid using DNS. The dumbbells are allowed to be advected non-affinely with the macroscopically-imposed deformation. More drastic drag reduction is achieved when non-affinity is maximum than in the complete affine case. In the former case, the dumbbell is convected as a covariant vector, and in the latter as a contravariant vector. We derive the exact solution for the governing equation of the motion of dumbbells. The maximum stretching of dumbbell is achieved when the dumbbell aligns in the direction of vorticity in the contravariant case, and when the dumbbell directs outward perpendicularly on the vortex sheet in the covariant case. Alignment in the BDS-DNS data agrees with the theoretical results. In the mixture of contravariant and covariant dumbbells, the covariant dumbbells are transversely aligned with the contravariant dumbbells. Compared with the cases without mixture, stretching of covariant dumbbell is enhanced, while that of contravariant dumbbell is reduced. Application of this phenomenon is discussed.
Aerosol Modeling for the Global Model Initiative
NASA Technical Reports Server (NTRS)
Weisenstein, Debra K.; Ko, Malcolm K. W.
2001-01-01
The goal of this project is to develop an aerosol module to be used within the framework of the Global Modeling Initiative (GMI). The model development work will be preformed jointly by the University of Michigan and AER, using existing aerosol models at the two institutions as starting points. The GMI aerosol model will be tested, evaluated against observations, and then applied to assessment of the effects of aircraft sulfur emissions as needed by the NASA Subsonic Assessment in 2001. The work includes the following tasks: 1. Implementation of the sulfur cycle within GMI, including sources, sinks, and aqueous conversion of sulfur. Aerosol modules will be added as they are developed and the GMI schedule permits. 2. Addition of aerosol types other than sulfate particles, including dust, soot, organic carbon, and black carbon. 3. Development of new and more efficient parameterizations for treating sulfate aerosol nucleation, condensation, and coagulation among different particle sizes and types.
Nonlinear Modeling by Assembling Piecewise Linear Models
NASA Technical Reports Server (NTRS)
Yao, Weigang; Liou, Meng-Sing
2013-01-01
To preserve nonlinearity of a full order system over a parameters range of interest, we propose a simple modeling approach by assembling a set of piecewise local solutions, including the first-order Taylor series terms expanded about some sampling states. The work by Rewienski and White inspired our use of piecewise linear local solutions. The assembly of these local approximations is accomplished by assigning nonlinear weights, through radial basis functions in this study. The efficacy of the proposed procedure is validated for a two-dimensional airfoil moving at different Mach numbers and pitching motions, under which the flow exhibits prominent nonlinear behaviors. All results confirm that our nonlinear model is accurate and stable for predicting not only aerodynamic forces but also detailed flowfields. Moreover, the model is robustness-accurate for inputs considerably different from the base trajectory in form and magnitude. This modeling preserves nonlinearity of the problems considered in a rather simple and accurate manner.
Aggregation in ecosystem models and model stability
NASA Astrophysics Data System (ADS)
Giricheva, Evgeniya
2015-05-01
Using a multimodal approach to research ecosystems improves usage of available information on an object. This study presents several models of the Bering Sea ecosystem. The ecosystem is considered as a closed object, that is, the influence of the environment is not provided. We then add the links with the external medium in the models. The models differ in terms of the degree and method of grouping components. Our method is based on the differences in habitat and food source of groups, which allows us to determine the grouping of species with a greater effect on system dynamics. In particular, we determine whether benthic fish aggregation or pelagic fish aggregation can change the consumption structure of some groups of species, and consequently, the behavior of the entire model system.
PREDICTIVE MODELS. Enhanced Oil Recovery Model
Ray, R.M.
1992-02-26
PREDICTIVE MODELS is a collection of five models - CFPM, CO2PM, ICPM, PFPM, and SFPM - used in the 1982-1984 National Petroleum Council study of enhanced oil recovery (EOR) potential. Each pertains to a specific EOR process designed to squeeze additional oil from aging or spent oil fields. The processes are: 1 chemical flooding, where soap-like surfactants are injected into the reservoir to wash out the oil; 2 carbon dioxide miscible flooding, where carbon dioxide mixes with the lighter hydrocarbons making the oil easier to displace; 3 in-situ combustion, which uses the heat from burning some of the underground oil to thin the product; 4 polymer flooding, where thick, cohesive material is pumped into a reservoir to push the oil through the underground rock; and 5 steamflood, where pressurized steam is injected underground to thin the oil. CFPM, the Chemical Flood Predictive Model, models micellar (surfactant)-polymer floods in reservoirs, which have been previously waterflooded to residual oil saturation. Thus, only true tertiary floods are considered. An option allows a rough estimate of oil recovery by caustic or caustic-polymer processes. CO2PM, the Carbon Dioxide miscible flooding Predictive Model, is applicable to both secondary (mobile oil) and tertiary (residual oil) floods, and to either continuous CO2 injection or water-alternating gas processes. ICPM, the In-situ Combustion Predictive Model, computes the recovery and profitability of an in-situ combustion project from generalized performance predictive algorithms. PFPM, the Polymer Flood Predictive Model, is switch-selectable for either polymer or waterflooding, and an option allows the calculation of the incremental oil recovery and economics of polymer relative to waterflooding. SFPM, the Steamflood Predictive Model, is applicable to the steam drive process, but not to cyclic steam injection (steam soak) processes.
ERIC Educational Resources Information Center
Brinner, Bonnie
1992-01-01
Presents an activity in which models help students visualize both the DNA process and transcription. After constructing DNA, RNA messenger, and RNA transfer molecules; students model cells, protein synthesis, codons, and RNA movement. (MDH)
Bounding Species Distribution Models
NASA Technical Reports Server (NTRS)
Stohlgren, Thomas J.; Jarnevich, Cahterine S.; Morisette, Jeffrey T.; Esaias, Wayne E.
2011-01-01
Species distribution models are increasing in popularity for mapping suitable habitat for species of management concern. Many investigators now recognize that extrapolations of these models with geographic information systems (GIS) might be sensitive to the environmental bounds of the data used in their development, yet there is no recommended best practice for "clamping" model extrapolations. We relied on two commonly used modeling approaches: classification and regression tree (CART) and maximum entropy (Maxent) models, and we tested a simple alteration of the model extrapolations, bounding extrapolations to the maximum and minimum values of primary environmental predictors, to provide a more realistic map of suitable habitat of hybridized Africanized honey bees in the southwestern United States. Findings suggest that multiple models of bounding, and the most conservative bounding of species distribution models, like those presented here, should probably replace the unbounded or loosely bounded techniques currently used [Current Zoology 57 (5): 642-647, 2011].
NASA Technical Reports Server (NTRS)
Butler, Thomas G.
1987-01-01
Methods of modeling mass for bars are surveyed. A method for extending John Archer's concept of consistent mass beyond just translational inertia effects is included. Recommendations are given for various types of modeling situations.
Green Infrastructure Modeling Toolkit
EPA's Green Infrastructure Modeling Toolkit is a toolkit of 5 EPA green infrastructure models and tools, along with communication materials, that can be used as a teaching tool and a quick reference resource when making GI implementation decisions.
NASA Technical Reports Server (NTRS)
1998-01-01
Model support system and instumentation cabling of the 1% scale X-33 reaction control system model. Installed in the Unitary Plan Wind Tunnel for supersonic testing. In building 1251, test section #2.
Until recently, sediment geochemical models (diagenetic models) have been only able to explain sedimentary flux and concentration profiles for a few simplified geochemical cycles (e.g., nitrogen, carbon and sulfur). However with advances in numerical methods, increased accuracy ...
Modeling EERE deployment programs
Cort, K. A.; Hostick, D. J.; Belzer, D. B.; Livingston, O. V.
2007-11-01
The purpose of the project was to identify and characterize the modeling of deployment programs within the EERE Technology Development (TD) programs, address possible improvements to the modeling process, and note gaps in knowledge for future research.
NASA Technical Reports Server (NTRS)
1991-01-01
This video explores the world of modeling at the NASA Johnson Space Center. Artisans create models, large and small, to help scientists and engineers make final design modifications before building more costly prototypes.
Rouder, Jeffrey N; Engelhardt, Christopher R; McCabe, Simon; Morey, Richard D
2016-12-01
Analysis of variance (ANOVA), the workhorse analysis of experimental designs, consists of F-tests of main effects and interactions. Yet, testing, including traditional ANOVA, has been recently critiqued on a number of theoretical and practical grounds. In light of these critiques, model comparison and model selection serve as an attractive alternative. Model comparison differs from testing in that one can support a null or nested model vis-a-vis a more general alternative by penalizing more flexible models. We argue this ability to support more simple models allows for more nuanced theoretical conclusions than provided by traditional ANOVA F-tests. We provide a model comparison strategy and show how ANOVA models may be reparameterized to better address substantive questions in data analysis.
NASA Technical Reports Server (NTRS)
Agena, S. M.; Pusey, M. L.; Bogle, I. D.
1999-01-01
A thermodynamic framework (UNIQUAC model with temperature dependent parameters) is applied to model the salt-induced protein crystallization equilibrium, i.e., protein solubility. The framework introduces a term for the solubility product describing protein transfer between the liquid and solid phase and a term for the solution behavior describing deviation from ideal solution. Protein solubility is modeled as a function of salt concentration and temperature for a four-component system consisting of a protein, pseudo solvent (water and buffer), cation, and anion (salt). Two different systems, lysozyme with sodium chloride and concanavalin A with ammonium sulfate, are investigated. Comparison of the modeled and experimental protein solubility data results in an average root mean square deviation of 5.8%, demonstrating that the model closely follows the experimental behavior. Model calculations and model parameters are reviewed to examine the model and protein crystallization process. Copyright 1999 John Wiley & Sons, Inc.
Consistent model driven architecture
NASA Astrophysics Data System (ADS)
Niepostyn, Stanisław J.
2015-09-01
The goal of the MDA is to produce software systems from abstract models in a way where human interaction is restricted to a minimum. These abstract models are based on the UML language. However, the semantics of UML models is defined in a natural language. Subsequently the verification of consistency of these diagrams is needed in order to identify errors in requirements at the early stage of the development process. The verification of consistency is difficult due to a semi-formal nature of UML diagrams. We propose automatic verification of consistency of the series of UML diagrams originating from abstract models implemented with our consistency rules. This Consistent Model Driven Architecture approach enables us to generate automatically complete workflow applications from consistent and complete models developed from abstract models (e.g. Business Context Diagram). Therefore, our method can be used to check practicability (feasibility) of software architecture models.
NASA Astrophysics Data System (ADS)
Okai, Tadashi; Otsuka, Takaharu; Arima, Akito
1992-02-01
We study the sp(8) subgroup of the isospin-invariant Ginnocchio model. The allowed quantum numbers are determined in terms of Young's diagrams. Using this result, we discuss the excitation energy of a model hamiltonian.
ERIC Educational Resources Information Center
Bennett, Joan
1998-01-01
Recommends the use of a model of DNA made out of Velcro to help students visualize the steps of DNA replication. Includes a materials list, construction directions, and details of the demonstration using the model parts. (DDR)
Bounding species distribution models
Stohlgren, T.J.; Jarnevich, C.S.; Esaias, W.E.; Morisette, J.T.
2011-01-01
Species distribution models are increasing in popularity for mapping suitable habitat for species of management concern. Many investigators now recognize that extrapolations of these models with geographic information systems (GIS) might be sensitive to the environmental bounds of the data used in their development, yet there is no recommended best practice for "clamping" model extrapolations. We relied on two commonly used modeling approaches: classification and regression tree (CART) and maximum entropy (Maxent) models, and we tested a simple alteration of the model extrapolations, bounding extrapolations to the maximum and minimum values of primary environmental predictors, to provide a more realistic map of suitable habitat of hybridized Africanized honey bees in the southwestern United States. Findings suggest that multiple models of bounding, and the most conservative bounding of species distribution models, like those presented here, should probably replace the unbounded or loosely bounded techniques currently used. ?? 2011 Current Zoology.
Modelling pelagic biogeography
NASA Astrophysics Data System (ADS)
Olson, Donald B.; Hood, Raleigh R.
Various combinations of physical and biological models are used to explore factors that determine the distribution of organisms in the world's oceans. The physical models examined include simple box models with parameterized inter-box exchanges that take into account variable box geometries, and specified continuous flows either in the Eulerian frame as stream-functions or as Lagrangian trajectories. A 1-dimensional mixed-layer model and a primitive equation channel model are introduced as examples of dynamical models depicting ocean physics. Biological models are discussed starting with a simple nitrogen (N), phytoplankton (P), zooplankton (Z) and detritus (D), NPZD formulation. The equilibria of this model is explored analytically as an example of computing steady state solutions, and then considering where in parameter space extinction occurs. Nonlinearities and expansion of NPZD to multi-species models are also treated. This is followed by the introduction of a nonlinear three-component food chain model, multi-species Lotka-Voltera competition models, and finally a discussion of structured population models including a derivation of a genetics model written in terms of genotypes. The physical models are then coupled with the biological ones in a series of examples. Both the box model with Lotka-Voltera multi-species population dynamics, and the 1-dimensional mixed-layer model with NPZD are used to demonstrate how the existence of spatial and temporal niches can allow a large number of species to coexist within biogeographic domains even though conditions at most sites and times are not conducive to supporting such diversity. These models recreate the basic diversity patterns observed in the pelagic ecosystem at various latitudes. The box model simulations also demonstrate the tendency for diffusive models to overestimate the dispersion of a species. In order to explore the dynamics of the edges of biogeographic domains a three species food chain model is
NASA Astrophysics Data System (ADS)
Tashiro, Tohru
2014-03-01
We propose a new model about diffusion of a product which includes a memory of how many adopters or advertisements a non-adopter met, where (non-)adopters mean people (not) possessing the product. This effect is lacking in the Bass model. As an application, we utilize the model to fit the iPod sales data, and so the better agreement is obtained than the Bass model.
Methodology for Stochastic Modeling.
1985-01-01
AD-AISS 851 METHODOLOGY FOR STOCHASTIC MODELING(U) ARMY MATERIEL 11 SYSTEMS ANALYSIS ACTIYITY ABERDEEN PROVING GROUND MD H E COHEN JAN 95 RNSAA-TR-41...FORM T REPORT NUMBER 2. GOVT ACCESSION NO. 3. RECIPIENT’$ CATALOG NUMBER 4. TITLE (and Subtitle) S. TYPE OF REPORT & PERIOD COVERED Methodology for...autoregression models, moving average models, ARMA, adaptive modeling, covariance methods , singular value decom- position, order determination rational
1982-07-01
AFWL-TR-82-9 AFWL-TR-82-9 REINFORCED CONCRETE MODELING H. L. Schreyer J. W. Jeter, Jr. New Mexico Engineering Reseprch Institute University of New...Subtitle) S. TYPE OF REPORT & PERIOD COVERED REINFORCED CONCRETE MODELING Final Report 6. PERFORMING OtG. REPORT NUMBER NMERI TA8-9 7. AUTHORg) S...loading were identified and used to evaluate current concrete models . Since the endochronic and viscoplastic models provide satisfactory descriptions
NASA Technical Reports Server (NTRS)
Mueller, A. C.
1977-01-01
An atmospheric model developed by Jacchia, quite accurate but requiring a large amount of computer storage and execution time, was found to be ill-suited for the space shuttle onboard program. The development of a simple atmospheric density model to simulate the Jacchia model was studied. Required characteristics including variation with solar activity, diurnal variation, variation with geomagnetic activity, semiannual variation, and variation with height were met by the new atmospheric density model.
NASA Technical Reports Server (NTRS)
Hildreth, W. W.
1978-01-01
A determination of the state of the art in soil moisture transport modeling based on physical or physiological principles was made. It was found that soil moisture models based on physical principles have been under development for more than 10 years. However, these models were shown to represent infiltration and redistribution of soil moisture quite well. Evapotranspiration has not been as adequately incorporated into the models.
Model Engineering using Multimodeling
2008-04-16
given as a Statecharts model, and interprets it as a hierarchical multimodel. We then show an equivalent model constructed with Ptolemy II [13] that...That work followed on Ptolemy Classic [9], which provided a software architecture supporting a general form of hierarchical multimodeling. In [9...Colif [10]. This approach does not segregate distinct models of computation hierarchically. Ptolemy Classic [9] also illustrated multi-view modeling
Mathematical circulatory system model
NASA Technical Reports Server (NTRS)
Lakin, William D. (Inventor); Stevens, Scott A. (Inventor)
2010-01-01
A system and method of modeling a circulatory system including a regulatory mechanism parameter. In one embodiment, a regulatory mechanism parameter in a lumped parameter model is represented as a logistic function. In another embodiment, the circulatory system model includes a compliant vessel, the model having a parameter representing a change in pressure due to contraction of smooth muscles of a wall of the vessel.
Future of groundwater modeling
Langevin, Christian D.; Panday, Sorab
2012-01-01
With an increasing need to better manage water resources, the future of groundwater modeling is bright and exciting. However, while the past can be described and the present is known, the future of groundwater modeling, just like a groundwater model result, is highly uncertain and any prediction is probably not going to be entirely representative. Thus we acknowledge this as we present our vision of where groundwater modeling may be headed.
Technology Transfer Automated Retrieval System (TEKTRAN)
Adsorption-desorption reactions are important processes that affect the transport of contaminants in the environment. Surface complexation models are chemical models that can account for the effects of variable chemical conditions, such as pH, on adsorption reactions. These models define specific ...
C. Lum
2004-09-16
The purpose of this model report is to document the Rock Properties Model version 3.1 with regard to input data, model methods, assumptions, uncertainties and limitations of model results, and qualification status of the model. The report also documents the differences between the current and previous versions and validation of the model. The rock properties model provides mean matrix and lithophysae porosity, and the cross-correlated mean bulk density as direct input to the ''Saturated Zone Flow and Transport Model Abstraction'', MDL-NBS-HS-000021, REV 02 (BSC 2004 [DIRS 170042]). The constraints, caveats, and limitations associated with this model are discussed in Section 6.6 and 8.2. Model validation accomplished by corroboration with data not cited as direct input is discussed in Section 7. The revision of this model report was performed as part of activities being conducted under the ''Technical Work Plan for: The Integrated Site Model, Revision 05'' (BSC 2004 [DIRS 169635]). The purpose of this revision is to bring the report up to current procedural requirements and address the Regulatory Integration Team evaluation comments. The work plan describes the scope, objectives, tasks, methodology, and procedures for this process.
General Graded Response Model.
ERIC Educational Resources Information Center
Samejima, Fumiko
This paper describes the graded response model. The graded response model represents a family of mathematical models that deal with ordered polytomous categories, such as: (1) letter grading; (2) an attitude survey with "strongly disagree, disagree, agree, and strongly agree" choices; (3) partial credit given in accord with an…
ERIC Educational Resources Information Center
Harris, Mary B.
To investigate the effect of modeling on altruism, 156 third and fifth grade children were exposed to a model who either shared with them, gave to a charity, or refused to share. The test apparatus, identified as a game, consisted of a box with signal lights and a chute through which marbles were dispensed. Subjects and the model played the game…
Designing cyclic universe models.
Khoury, Justin; Steinhardt, Paul J; Turok, Neil
2004-01-23
The phenomenological constraints on the scalar field potential in cyclic models of the Universe are presented. We show that cyclic models require a comparable degree of tuning to that needed for inflationary models. The constraints are reduced to a set of simple design rules including "fast-roll" parameters analogous to the "slow-roll" parameters in inflation.
ERIC Educational Resources Information Center
Meara, Paul
2004-01-01
This paper describes some simple simulation models of vocabulary attrition. The attrition process is modelled using a random autonomous Boolean network model, and some parallels with real attrition data are drawn. The paper argues that applying a complex systems approach to attrition can provide some important insights, which suggest that real…
Open Source Molecular Modeling
Pirhadi, Somayeh; Sunseri, Jocelyn; Koes, David Ryan
2016-01-01
The success of molecular modeling and computational chemistry efforts are, by definition, dependent on quality software applications. Open source software development provides many advantages to users of modeling applications, not the least of which is that the software is free and completely extendable. In this review we categorize, enumerate, and describe available open source software packages for molecular modeling and computational chemistry. PMID:27631126
ERIC Educational Resources Information Center
Thornton, Bradley D.; Smalley, Robert A.
2008-01-01
Building information modeling (BIM) uses three-dimensional modeling concepts, information technology and interoperable software to design, construct and operate a facility. However, BIM can be more than a tool for virtual modeling--it can provide schools with a 3-D walkthrough of a project while it still is on the electronic drawing board. BIM can…
Modeling EERE Deployment Programs
Cort, K. A.; Hostick, D. J.; Belzer, D. B.; Livingston, O. V.
2007-11-01
This report compiles information and conclusions gathered as part of the “Modeling EERE Deployment Programs” project. The purpose of the project was to identify and characterize the modeling of deployment programs within the EERE Technology Development (TD) programs, address possible improvements to the modeling process, and note gaps in knowledge in which future research is needed.
Modeling Applications and Tools
The U.S. EPA's Air Quality Modeling Group (AQMG) conducts modeling analyses to support policy and regulatory decisions in OAR and provides leadership and direction on the full range of air quality models and other mathematical simulation techniques used in
ERIC Educational Resources Information Center
Fitzsimmons, Charles P.
1986-01-01
Points out the instructional applications and program possibilities of a unit on model rocketry. Describes the ways that microcomputers can assist in model rocket design and in problem calculations. Provides a descriptive listing of model rocket software for the Apple II microcomputer. (ML)
Sharlemann, E.T.
1994-07-01
We are developing a DIAL performance model for CALIOPE at LLNL. The intent of the model is to provide quick and interactive parameter sensitivity calculations with immediate graphical output. A brief overview of the features of the performance model is given, along with an example of performance calculations for a non-CALIOPE application.
Modeling and Remodeling Writing
ERIC Educational Resources Information Center
Hayes, John R.
2012-01-01
In Section 1 of this article, the author discusses the succession of models of adult writing that he and his colleagues have proposed from 1980 to the present. He notes the most important changes that differentiate earlier and later models and discusses reasons for the changes. In Section 2, he describes his recent efforts to model young…
Campus Energy Modeling Platform
Sides, Scott; Kemper, Travis; Larsen, Ross; Graf, Peter
2014-09-19
NREL's Campus Energy Modeling project provides a suite of simulation tools for integrated, data driven energy modeling of commercial buildings and campuses using Simulink. The tools enable development of fully interconnected models for commercial campus energy infrastructure, including electrical distribution systems, district heating and cooling, onsite generation (both conventional and renewable), building loads, energy storage, and control systems.
ERIC Educational Resources Information Center
Bogiages, Christopher A.; Lotter, Christine
2011-01-01
In their research, scientists generate, test, and modify scientific models. These models can be shared with others and demonstrate a scientist's understanding of how the natural world works. Similarly, students can generate and modify models to gain a better understanding of the content, process, and nature of science (Kenyon, Schwarz, and Hug…
NASA Astrophysics Data System (ADS)
Peterson, Matthew C.
1991-08-01
The United States Air Force Environmental Technical Applications Center (USAFETAC) was tasked to review the scientific literature for studies of the Groves Neutral Density Climatology Model and compare the Groves Model with others in the 30-60 km range. The tasking included a request to investigate the merits of comparing accuracy of the Groves Model to rocketsonde data. USAFETAC analysts found the Groves Model to be state of the art for middle-atmospheric climatological models. In reviewing previous comparisons with other models and with space shuttle-derived atmospheric densities, good density vs altitude agreement was found in almost all cases. A simple technique involving comparison of the model with range reference atmospheres was found to be the most economical way to compare the Groves Model with rocketsonde data; an example of this type is provided. The Groves 85 Model is used routinely in USAFETAC's Improved Point Analysis Model (IPAM). To create this model, Dr. Gerald Vann Groves produced tabulations of atmospheric density based on data derived from satellite observations and modified by rocketsonde observations. Neutral Density as presented here refers to the monthly mean density in 10-degree latitude bands as a function of altitude. The Groves 85 Model zonal mean density tabulations are given in their entirety.
ERIC Educational Resources Information Center
Ayers, Jerry B.; And Others
1988-01-01
The Accreditation Plus model developed by the Center for Teacher Education Evaluation of Tennessee Technological University (Cookeville) for evaluation of teacher education programs is described. An amalgamation of the accreditation model and use-tailored evaluation plans, the model calls for informed eclecticism in the assembly of evaluation…
Improved analytic nutation model
NASA Technical Reports Server (NTRS)
Yoder, C. F.; Ivins, E. R.
1988-01-01
Models describing the earth's nutations are discussed. It is found that the simple model of Sasao et al., (1981) differs from Wahr's (1981) theory term by term by less than 0.3 marcsec if a modern earth structure model is used to evaluate the nutation structure constants. In addition, the effect of oceans is estimated.
ERIC Educational Resources Information Center
Walsh, Jim; McGehee, Richard
2013-01-01
A dynamical systems approach to energy balance models of climate is presented, focusing on low order, or conceptual, models. Included are global average and latitude-dependent, surface temperature models. The development and analysis of the differential equations and corresponding bifurcation diagrams provides a host of appropriate material for…
Model Breaking Points Conceptualized
ERIC Educational Resources Information Center
Vig, Rozy; Murray, Eileen; Star, Jon R.
2014-01-01
Current curriculum initiatives (e.g., National Governors Association Center for Best Practices and Council of Chief State School Officers 2010) advocate that models be used in the mathematics classroom. However, despite their apparent promise, there comes a point when models break, a point in the mathematical problem space where the model cannot,…
ERIC Educational Resources Information Center
Fedorov, Alexander
2011-01-01
The author supposed that media education models can be divided into the following groups: (1) educational-information models (the study of the theory, history, language of media culture, etc.), based on the cultural, aesthetic, semiotic, socio-cultural theories of media education; (2) educational-ethical models (the study of moral, religions,…
ERIC Educational Resources Information Center
Land, Kenneth C.
2001-01-01
Examines the definition, construction, and interpretation of social indicators. Shows how standard classes of formalisms used to construct models in contemporary sociology are derived from the general theory of models. Reviews recent model building and evaluation related to active life expectancy among the elderly, fertility rates, and indicators…
Generalized Latent Trait Models.
ERIC Educational Resources Information Center
Moustaki, Irini; Knott, Martin
2000-01-01
Discusses a general model framework within which manifest variables with different distributions in the exponential family can be analyzed with a latent trait model. Presents a unified maximum likelihood method for estimating the parameters of the generalized latent trait model and discusses the scoring of individuals on the latent dimensions.…
ERIC Educational Resources Information Center
Goodman, Richard E.
1970-01-01
Describes types of molecular models (ball-and-stick, framework, and space-filling) and evaluates commercially available kits. Gives instructions for constructive models from polystyrene balls and pipe-cleaners. Models are useful for class demonstrations although not sufficiently accurate for research use. Illustrations show biologically important…
ERIC Educational Resources Information Center
Summerlin, Lee; Borgford, Christie
1989-01-01
Described is an activity which uses a 96-well reaction plate and soda straws to construct a model of the periodic table of the elements. The model illustrates the ionization energies of the various elements. Construction of the model and related concepts are discussed. (CW)
ERIC Educational Resources Information Center
Speiser, Bob; Walter, Chuck
2011-01-01
This paper explores how models can support productive thinking. For us a model is a "thing", a tool to help make sense of something. We restrict attention to specific models for whole-number multiplication, hence the wording of the title. They support evolving thinking in large measure through the ways their users redesign them. They assume new…
Simulating the Rayleigh-Taylor instability in polymer fluids with dissipative particle dynamics
NASA Astrophysics Data System (ADS)
Li, Yanggui; Geng, Xingguo; Zhuang, Xin; Wang, Lihua; Ouyang, Jie
2016-04-01
The Rayleigh-Taylor (RT) instability that occurs in the flow of polymer fluids is numerically investigated with dissipative particle dynamics (DPD) method at the mesoscale particle level. For modeling two-phase flow, the Flory-Huggins parameter is introduced to model binary fluids. And the polymer chains in fluids are described by the modified FENE model that depicts both the elastic tension and the elastic repulsion between the adjacent beads with bond length as the equilibrium length of one segment. Besides, a bead repulsive potential is employed to capture entanglements between polymer chains. Through our model and numerical simulation, we research the dynamics behaviors of the RT instability in polymer fluid medium. Furthermore, we also explore the effects of polymer volume concentration, chain length, and extensibility on the evolution of RT instability. These simulation results show that increasing any of the parameters, concentration, chain length, and extensibility, the saturation length of spikes becomes longer, and the two polymer fluids have less mixture. On the contrary, for the case of low concentration, or short chain, or small extensibility, the spikes easily split and break up, and the RT instability pattern evolves into chaotic structure. These observations indicate that the polymer and its properties drastically modify the RT instability pattern.
Advances in Watershed Models and Modeling
NASA Astrophysics Data System (ADS)
Yeh, G. T.; Zhang, F.
2015-12-01
The development of watershed models and their applications to real-world problems has evolved significantly since 1960's. Watershed models can be classified based on what media are included, what processes are dealt with, and what approaches are taken. In term of media, a watershed may include segregated overland regime, river-canal-open channel networks, ponds-reservoirs-small lakes, and subsurface media. It may also include integrated media of all these or a partial set of these as well as man-made control structures. In term of processes, a watershed model may deal with coupled or decoupled hydrological and biogeochemical cycles. These processes include fluid flow, thermal transport, salinity transport, sediment transport, reactive transport, and biota and microbe kinetics. In terms of approaches, either parametric or physics-based approach can be taken. This talk discusses the evolution of watershed models in the past sixty years. The advances of watershed models center around their increasing design capability to foster these segregated or integrated media and coupled or decoupled processes. Widely used models developed by academia, research institutes, government agencies, and private industries will be reviewed in terms of the media and processes included as well as approaches taken. Many types of potential benchmark problems in general can be proposed and will be discussed. This presentation will focus on three benchmark problems of biogeochemical cycles. These three problems, dealing with water quality transport, will be formulated in terms of reactive transport. Simulation results will be illustrated using WASH123D, a watershed model developed and continuously updated by the author and his PhD graduates. Keywords: Hydrological Cycles, Biogeochemical Cycles, Biota Kinetics, Parametric Approach, Physics-based Approach, Reactive Transport.
Yum, Soo-Young; Yoon, Ki-Young; Lee, Choong-Il; Lee, Byeong-Chun
2016-01-01
Animal models, particularly pigs, have come to play an important role in translational biomedical research. There have been many pig models with genetically modifications via somatic cell nuclear transfer (SCNT). However, because most transgenic pigs have been produced by random integration to date, the necessity for more exact gene-mutated models using recombinase based conditional gene expression like mice has been raised. Currently, advanced genome-editing technologies enable us to generate specific gene-deleted and -inserted pig models. In the future, the development of pig models with gene editing technologies could be a valuable resource for biomedical research. PMID:27030199
M. McGraw
2000-04-13
The UZ Colloid Transport model development plan states that the objective of this Analysis/Model Report (AMR) is to document the development of a model for simulating unsaturated colloid transport. This objective includes the following: (1) use of a process level model to evaluate the potential mechanisms for colloid transport at Yucca Mountain; (2) Provide ranges of parameters for significant colloid transport processes to Performance Assessment (PA) for the unsaturated zone (UZ); (3) Provide a basis for development of an abstracted model for use in PA calculations.
Mathematical modeling in neuroendocrinology.
Bertram, Richard
2015-04-01
Mathematical models are commonly used in neuroscience, both as tools for integrating data and as devices for designing new experiments that test model predictions. The wide range of relevant spatial and temporal scales in the neuroendocrine system makes neuroendocrinology a branch of neuroscience with great potential for modeling. This article provides an overview of concepts that are useful for understanding mathematical models of the neuroendocrine system, as well as design principles that have been illuminated through the use of mathematical models. These principles are found over and over again in cellular dynamics, and serve as building blocks for understanding some of the complex temporal dynamics that are exhibited throughout the neuroendocrine system.
NASA Astrophysics Data System (ADS)
Alves, Daniele S. M.; Galloway, Jamison; McCullough, Matthew; Weiner, Neal
2016-04-01
Models with Dirac gauginos are appealing scenarios for physics beyond the Standard Model. They have smaller radiative corrections to scalar soft masses, a suppression of certain supersymmetry (SUSY) production processes at the LHC, and ameliorated flavor constraints. Unfortunately, they are generically plagued by tachyons charged under the Standard Model, and attempts to eliminate such states typically spoil the positive features. The recently proposed "Goldstone gaugino" mechanism provides a simple realization of Dirac gauginos that is automatically free of dangerous tachyonic states. We provide details on this mechanism and explore models for its origin. In particular, we find SUSY QCD models that realize this idea simply and discuss scenarios for unification.
NASA Technical Reports Server (NTRS)
Meister, Jeffrey P.
1987-01-01
The Mechanics of Materials Model (MOMM) is a three-dimensional inelastic structural analysis code for use as an early design stage tool for hot section components. MOMM is a stiffness method finite element code that uses a network of beams to characterize component behavior. The MOMM contains three material models to account for inelastic material behavior. These include the simplified material model, which assumes a bilinear stress-strain response; the state-of-the-art model, which utilizes the classical elastic-plastic-creep strain decomposition; and Walker's viscoplastic model, which accounts for the interaction between creep and plasticity that occurs under cyclic loading conditions.
Storjohann, K.
1990-01-01
This paper describes an imaging model that was derived for use with a laser range camera (LRC) developed by the Advanced Intelligent Machines Division of Odetics. However, this model could be applied to any comparable imaging system. Both the derivation of the model and the determination of the LRC's intrinsic parameters are explained. For the purpose of evaluating the LRC's extrinsic parameters, i.e., its external orientation, a transformation of the LRC's imaging model into a standard camera's (SC) pinhole model is derived. By virtue of this transformation, the evaluation of the LRC's external orientation can be found by applying any SC calibration technique.
NASA Astrophysics Data System (ADS)
Marion, Giles M.; Kargel, Jeffrey S.
Implementation of the Pitzer approach is through the FREZCHEM (FREEZING CHEMISTRY) model, which is at the core of this work. This model was originally designed to simulate salt chemistries and freezing processes at low temperatures (-54 to 25°C) and 1 atm pressure. Over the years, this model has been broadened to include more chemistries (from 16 to 58 solid phases), a broader temperature range for some chemistries (to 113°C), and incorporation of a pressure dependence (1 to 1000 bars) into the model. Implementation, parameterization, validation, and limitations of the FREZCHEM model are extensively discussed in Chapter 3.
NASA Astrophysics Data System (ADS)
Fischer, Arthur E.
1996-01-01
In this paper a theory of models of the universe is proposed. We refer to such models ascosmological models, where a cosmological model is defined as an Einstein-inextendible Einstein spacetime. A cosmological model isabsolute if it is a Lorentz-inextendible Einstein spacetime,predictive if it is globally hyperbolic, andnon-predictive if it is nonglobally-hyperbolic. We discuss several features of these models in the study of cosmology. As an example, any compact Einstein spacetime is always a non-predictive absolute cosmological model, whereas a noncompact complete Einstein spacetime is an absolute cosmological model which may be either predictive or non-predictive. We discuss the important role played by maximal Einstein spacetimes. In particular, we examine the possible proper Lorentz-extensions of such spacetimes, and show that a spatially compact maximal Einstein spacetime is exclusively either a predictive cosmological model or a proper sub-spacetime of a non-predictive cosmological model. Provided that the Strong Cosmic Censorship conjecture is true, a generic spatially compact maximal Einstein spacetime must be a predictive cosmological model. It isconjectured that the Strong Cosmic Censorship conjecture isnot true, and converting a vice to a virtue it is argued that the failure of the Strong Cosmic Censorship conjecture would point to what may be general relativity's greatest prediction of all, namely,that general relativity predicts that general relativity cannot predict the entire history of the universe.
Collins, Lisa M.; Part, Chérie E.
2013-01-01
Simple Summary In this review paper we discuss the different modeling techniques that have been used in animal welfare research to date. We look at what questions they have been used to answer, the advantages and pitfalls of the methods, and how future research can best use these approaches to answer some of the most important upcoming questions in farm animal welfare. Abstract The use of models in the life sciences has greatly expanded in scope and advanced in technique in recent decades. However, the range, type and complexity of models used in farm animal welfare is comparatively poor, despite the great scope for use of modeling in this field of research. In this paper, we review the different modeling approaches used in farm animal welfare science to date, discussing the types of questions they have been used to answer, the merits and problems associated with the method, and possible future applications of each technique. We find that the most frequently published types of model used in farm animal welfare are conceptual and assessment models; two types of model that are frequently (though not exclusively) based on expert opinion. Simulation, optimization, scenario, and systems modeling approaches are rarer in animal welfare, despite being commonly used in other related fields. Finally, common issues such as a lack of quantitative data to parameterize models, and model selection and validation are discussed throughout the review, with possible solutions and alternative approaches suggested. PMID:26487411
Distributed fuzzy system modeling
Pedrycz, W.; Chi Fung Lam, P.; Rocha, A.F.
1995-05-01
The paper introduces and studies an idea of distributed modeling treating it as a new paradigm of fuzzy system modeling and analysis. This form of modeling is oriented towards developing individual (local) fuzzy models for specific modeling landmarks (expressed as fuzzy sets) and determining the essential logical relationships between these local models. The models themselves are implemented in the form of logic processors being regarded as specialized fuzzy neural networks. The interaction between the processors is developed either in an inhibitory or excitatory way. In more descriptive way, the distributed model can be sought as a collection of fuzzy finite state machines with their individual local first or higher order memories. It is also clarified how the concept of distributed modeling narrows down a gap between purely numerical (quantitative) models and the qualitative ones originated within the realm of Artificial Intelligence. The overall architecture of distributed modeling is discussed along with the detailed learning schemes. The results of extensive simulation experiments are provided as well. 17 refs.
Horizontal model fusion paradigm
NASA Astrophysics Data System (ADS)
Julier, Simon J.; Durrant-Whyte, Hugh F.
1996-05-01
In navigation and tracking problems, the identification of an appropriate model of vehicular or target motion is vital to most practical data fusion algorithms. The true system dynamics are rarely known, and approximations are usually employed. Since systems can exhibit strikingly different behaviors, multiple models may be needed to describe each of these behaviors. Current methods either use model switching (a single process model is chosen from the set using a decision rule) or consider the models as a set of competing hypothesis, only one of which is 'correct'. However, these methods fail to exploit the fact that all models are of the same system and that all of them are, to some degree, 'correct'. In this paper we present a new paradigm for fusing information from a set of multiple process models. The predictions from each process model are regarded as observations which are corrupted by correlated noise. By employing the standard Kalman filter equations we combine data from multiple sensors and multiple process models optimally. There are a number of significant practical advantages to this technique. First, the performance of the system always equals or betters that of the best estimator in the set of models being used. Second, the same decision theoretic machinery can be used to select the process models as well as the sensor suites.
T. Ghezzehej
2004-10-04
The purpose of this model report is to document the calibrated properties model that provides calibrated property sets for unsaturated zone (UZ) flow and transport process models (UZ models). The calibration of the property sets is performed through inverse modeling. This work followed, and was planned in, ''Technical Work Plan (TWP) for: Unsaturated Zone Flow Analysis and Model Report Integration'' (BSC 2004 [DIRS 169654], Sections 1.2.6 and 2.1.1.6). Direct inputs to this model report were derived from the following upstream analysis and model reports: ''Analysis of Hydrologic Properties Data'' (BSC 2004 [DIRS 170038]); ''Development of Numerical Grids for UZ Flow and Transport Modeling'' (BSC 2004 [DIRS 169855]); ''Simulation of Net Infiltration for Present-Day and Potential Future Climates'' (BSC 2004 [DIRS 170007]); ''Geologic Framework Model'' (GFM2000) (BSC 2004 [DIRS 170029]). Additionally, this model report incorporates errata of the previous version and closure of the Key Technical Issue agreement TSPAI 3.26 (Section 6.2.2 and Appendix B), and it is revised for improved transparency.
Johnson, Douglas H.; Cook, R.D.
2013-01-01
In her AAAS News & Notes piece "Can the Southwest manage its thirst?" (26 July, p. 362), K. Wren quotes Ajay Kalra, who advocates a particular method for predicting Colorado River streamflow "because it eschews complex physical climate models for a statistical data-driven modeling approach." A preference for data-driven models may be appropriate in this individual situation, but it is not so generally, Data-driven models often come with a warning against extrapolating beyond the range of the data used to develop the models. When the future is like the past, data-driven models can work well for prediction, but it is easy to over-model local or transient phenomena, often leading to predictive inaccuracy (1). Mechanistic models are built on established knowledge of the process that connects the response variables with the predictors, using information obtained outside of an extant data set. One may shy away from a mechanistic approach when the underlying process is judged to be too complicated, but good predictive models can be constructed with statistical components that account for ingredients missing in the mechanistic analysis. Models with sound mechanistic components are more generally applicable and robust than data-driven models.
NASA Technical Reports Server (NTRS)
Tijidjian, Raffi P.
2010-01-01
The TEAMS model analyzer is a supporting tool developed to work with models created with TEAMS (Testability, Engineering, and Maintenance System), which was developed by QSI. In an effort to reduce the time spent in the manual process that each TEAMS modeler must perform in the preparation of reporting for model reviews, a new tool has been developed as an aid to models developed in TEAMS. The software allows for the viewing, reporting, and checking of TEAMS models that are checked into the TEAMS model database. The software allows the user to selectively model in a hierarchical tree outline view that displays the components, failure modes, and ports. The reporting features allow the user to quickly gather statistics about the model, and generate an input/output report pertaining to all of the components. Rules can be automatically validated against the model, with a report generated containing resulting inconsistencies. In addition to reducing manual effort, this software also provides an automated process framework for the Verification and Validation (V&V) effort that will follow development of these models. The aid of such an automated tool would have a significant impact on the V&V process.
Physical modelling in biomechanics.
Koehl, M A R
2003-01-01
Physical models, like mathematical models, are useful tools in biomechanical research. Physical models enable investigators to explore parameter space in a way that is not possible using a comparative approach with living organisms: parameters can be varied one at a time to measure the performance consequences of each, while values and combinations not found in nature can be tested. Experiments using physical models in the laboratory or field can circumvent problems posed by uncooperative or endangered organisms. Physical models also permit some aspects of the biomechanical performance of extinct organisms to be measured. Use of properly scaled physical models allows detailed physical measurements to be made for organisms that are too small or fast to be easily studied directly. The process of physical modelling and the advantages and limitations of this approach are illustrated using examples from our research on hydrodynamic forces on sessile organisms, mechanics of hydraulic skeletons, food capture by zooplankton and odour interception by olfactory antennules. PMID:14561350
Shipman, Galen M.
2016-06-13
These are the slides for a presentation on programming models in HPC, at the Los Alamos National Laboratory's Parallel Computing Summer School. The following topics are covered: Flynn's Taxonomy of computer architectures; single instruction single data; single instruction multiple data; multiple instruction multiple data; address space organization; definition of Trinity (Intel Xeon-Phi is a MIMD architecture); single program multiple data; multiple program multiple data; ExMatEx workflow overview; definition of a programming model, programming languages, runtime systems; programming model and environments; MPI (Message Passing Interface); OpenMP; Kokkos (Performance Portable Thread-Parallel Programming Model); Kokkos abstractions, patterns, policies, and spaces; RAJA, a systematic approach to node-level portability and tuning; overview of the Legion Programming Model; mapping tasks and data to hardware resources; interoperability: supporting task-level models; Legion S3D execution and performance details; workflow, integration of external resources into the programming model.
Moffat, Harry K.; Noble, David R.; Baer, Thomas A.; Adolf, Douglas Brian; Rao, Rekha Ranjana; Mondy, Lisa Ann
2008-09-01
In this report, we summarize our work on developing a production level foam processing computational model suitable for predicting the self-expansion of foam in complex geometries. The model is based on a finite element representation of the equations of motion, with the movement of the free surface represented using the level set method, and has been implemented in SIERRA/ARIA. An empirically based time- and temperature-dependent density model is used to encapsulate the complex physics of foam nucleation and growth in a numerically tractable model. The change in density with time is at the heart of the foam self-expansion as it creates the motion of the foam. This continuum-level model uses an homogenized description of foam, which does not include the gas explicitly. Results from the model are compared to temperature-instrumented flow visualization experiments giving the location of the foam front as a function of time for our EFAR model system.
Toward Scientific Numerical Modeling
NASA Technical Reports Server (NTRS)
Kleb, Bil
2007-01-01
Ultimately, scientific numerical models need quantified output uncertainties so that modeling can evolve to better match reality. Documenting model input uncertainties and verifying that numerical models are translated into code correctly, however, are necessary first steps toward that goal. Without known input parameter uncertainties, model sensitivities are all one can determine, and without code verification, output uncertainties are simply not reliable. To address these two shortcomings, two proposals are offered: (1) an unobtrusive mechanism to document input parameter uncertainties in situ and (2) an adaptation of the Scientific Method to numerical model development and deployment. Because these two steps require changes in the computational simulation community to bear fruit, they are presented in terms of the Beckhard-Harris-Gleicher change model.
Modelling structured data with Probabilistic Graphical Models
NASA Astrophysics Data System (ADS)
Forbes, F.
2016-05-01
Most clustering and classification methods are based on the assumption that the objects to be clustered are independent. However, in more and more modern applications, data are structured in a way that makes this assumption not realistic and potentially misleading. A typical example that can be viewed as a clustering task is image segmentation where the objects are the pixels on a regular grid and depend on neighbouring pixels on this grid. Also, when data are geographically located, it is of interest to cluster data with an underlying dependence structure accounting for some spatial localisation. These spatial interactions can be naturally encoded via a graph not necessarily regular as a grid. Data sets can then be modelled via Markov random fields and mixture models (e.g. the so-called MRF and Hidden MRF). More generally, probabilistic graphical models are tools that can be used to represent and manipulate data in a structured way while modeling uncertainty. This chapter introduces the basic concepts. The two main classes of probabilistic graphical models are considered: Bayesian networks and Markov networks. The key concept of conditional independence and its link to Markov properties is presented. The main problems that can be solved with such tools are described. Some illustrations are given associated with some practical work.
V. Chipman; J. Case
2002-12-20
The purpose of the Ventilation Model is to simulate the heat transfer processes in and around waste emplacement drifts during periods of forced ventilation. The model evaluates the effects of emplacement drift ventilation on the thermal conditions in the emplacement drifts and surrounding rock mass, and calculates the heat removal by ventilation as a measure of the viability of ventilation to delay the onset of peak repository temperature and reduce its magnitude. The heat removal by ventilation is temporally and spatially dependent, and is expressed as the fraction of heat carried away by the ventilation air compared to the fraction of heat produced by radionuclide decay. One minus the heat removal is called the wall heat fraction, or the remaining amount of heat that is transferred via conduction to the surrounding rock mass. Downstream models, such as the ''Multiscale Thermohydrologic Model'' (BSC 2001), use the wall heat fractions as outputted from the Ventilation Model to initialize their post-closure analyses. The Ventilation Model report was initially developed to analyze the effects of preclosure continuous ventilation in the Engineered Barrier System (EBS) emplacement drifts, and to provide heat removal data to support EBS design. Revision 00 of the Ventilation Model included documentation of the modeling results from the ANSYS-based heat transfer model. Revision 01 ICN 01 included the results of the unqualified software code MULTIFLUX to assess the influence of moisture on the ventilation efficiency. The purposes of Revision 02 of the Ventilation Model are: (1) To validate the conceptual model for preclosure ventilation of emplacement drifts and verify its numerical application in accordance with new procedural requirements as outlined in AP-SIII-10Q, Models (Section 7.0). (2) To satisfy technical issues posed in KTI agreement RDTME 3.14 (Reamer and Williams 2001a). Specifically to demonstrate, with respect to the ANSYS ventilation model, the adequacy of
Phyloclimatic modeling: combining phylogenetics and bioclimatic modeling.
Yesson, C; Culham, A
2006-10-01
We investigate the impact of past climates on plant diversification by tracking the "footprint" of climate change on a phylogenetic tree. Diversity within the cosmopolitan carnivorous plant genus Drosera (Droseraceae) is focused within Mediterranean climate regions. We explore whether this diversity is temporally linked to Mediterranean-type climatic shifts of the mid-Miocene and whether climate preferences are conservative over phylogenetic timescales. Phyloclimatic modeling combines environmental niche (bioclimatic) modeling with phylogenetics in order to study evolutionary patterns in relation to climate change. We present the largest and most complete such example to date using Drosera. The bioclimatic models of extant species demonstrate clear phylogenetic patterns; this is particularly evident for the tuberous sundews from southwestern Australia (subgenus Ergaleium). We employ a method for establishing confidence intervals of node ages on a phylogeny using replicates from a Bayesian phylogenetic analysis. This chronogram shows that many clades, including subgenus Ergaleium and section Bryastrum, diversified during the establishment of the Mediterranean-type climate. Ancestral reconstructions of bioclimatic models demonstrate a pattern of preference for this climate type within these groups. Ancestral bioclimatic models are projected into palaeo-climate reconstructions for the time periods indicated by the chronogram. We present two such examples that each generate plausible estimates of ancestral lineage distribution, which are similar to their current distributions. This is the first study to attempt bioclimatic projections on evolutionary time scales. The sundews appear to have diversified in response to local climate development. Some groups are specialized for Mediterranean climates, others show wide-ranging generalism. This demonstrates that Phyloclimatic modeling could be repeated for other plant groups and is fundamental to the understanding of
Hammerand, Daniel Carl; Scherzinger, William Mark
2007-09-01
The Library of Advanced Materials for Engineering (LAME) provides a common repository for constitutive models that can be used in computational solid mechanics codes. A number of models including both hypoelastic (rate) and hyperelastic (total strain) constitutive forms have been implemented in LAME. The structure and testing of LAME is described in Scherzinger and Hammerand ([3] and [4]). The purpose of the present report is to describe the material models which have already been implemented into LAME. The descriptions are designed to give useful information to both analysts and code developers. Thus far, 33 non-ITAR/non-CRADA protected material models have been incorporated. These include everything from the simple isotropic linear elastic models to a number of elastic-plastic models for metals to models for honeycomb, foams, potting epoxies and rubber. A complete description of each model is outside the scope of the current report. Rather, the aim here is to delineate the properties, state variables, functions, and methods for each model. However, a brief description of some of the constitutive details is provided for a number of the material models. Where appropriate, the SAND reports available for each model have been cited. Many models have state variable aliases for some or all of their state variables. These alias names can be used for outputting desired quantities. The state variable aliases available for results output have been listed in this report. However, not all models use these aliases. For those models, no state variable names are listed. Nevertheless, the number of state variables employed by each model is always given. Currently, there are four possible functions for a material model. This report lists which of these four methods are employed in each material model. As far as analysts are concerned, this information is included only for the awareness purposes. The analyst can take confidence in the fact that model has been properly implemented
Modeling and Prediction Overview
Ermak, D L
2002-10-18
Effective preparation for and response to the release of toxic materials into the atmosphere hinges on accurate predictions of the dispersion pathway, concentration, and ultimate fate of the chemical or biological agent. Of particular interest is the threat to civilian populations within major urban areas, which are likely targets for potential attacks. The goals of the CBNP Modeling and Prediction area are: (1) Development of a suite of validated, multi-scale, atmospheric transport and fate modeling capabilities for chemical and biological agent releases within the complex urban environment; (2) Integration of these models and related user tools into operational emergency response systems. Existing transport and fate models are being adapted to treat the complex atmospheric flows within and around structures (e.g., buildings, subway systems, urban areas) and over terrain. Relevant source terms and the chemical and physical behavior of gas- and particle-phase species (e.g., losses due to deposition, bio-agent viability, degradation) are also being developed and incorporated into the models. Model validation is performed using both laboratory and field data. CBNP is producing and testing a suite of models with differing levels of complexity and fidelity to address the full range of user needs and applications. Lumped-parameter transport models are being developed for subway systems and building interiors, supplemented by the use of computational fluid dynamics (CFD) models to describe the circulation within large, open spaces such as auditoriums. Both sophisticated CFD transport models and simpler fast-response models are under development to treat the complex flow around individual structures and arrays of buildings. Urban parameterizations are being incorporated into regional-scale weather forecast, meteorological data assimilation, and dispersion models for problems involving larger-scale urban and suburban areas. Source term and dose response models are being
NASA Astrophysics Data System (ADS)
Mishra, Ashok K.; Singh, Vijay P.
2011-06-01
SummaryIn recent years droughts have been occurring frequently, and their impacts are being aggravated by the rise in water demand and the variability in hydro-meteorological variables due to climate change. As a result, drought hydrology has been receiving much attention. A variety of concepts have been applied to modeling droughts, ranging from simplistic approaches to more complex models. It is important to understand different modeling approaches as well as their advantages and limitations. This paper, supplementing the previous paper ( Mishra and Singh, 2010) where different concepts of droughts were highlighted, reviews different methodologies used for drought modeling, which include drought forecasting, probability based modeling, spatio-temporal analysis, use of Global Climate Models (GCMs) for drought scenarios, land data assimilation systems for drought modeling, and drought planning. It is found that there have been significant improvements in modeling droughts over the past three decades. Hybrid models, incorporating large scale climate indices, seem to be promising for long lead-time drought forecasting. Further research is needed to understand the spatio-temporal complexity of droughts under climate change due to changes in spatio-temporal variability of precipitation. Applications of copula based models for multivariate drought characterization seem to be promising for better drought characterization. Research on decision support systems should be advanced for issuing warnings, assessing risk, and taking precautionary measures, and the effective ways for the flow of information from decision makers to users need to be developed. Finally, some remarks are made regarding the future outlook for drought research.
Quantitative Rheological Model Selection
NASA Astrophysics Data System (ADS)
Freund, Jonathan; Ewoldt, Randy
2014-11-01
The more parameters in a rheological the better it will reproduce available data, though this does not mean that it is necessarily a better justified model. Good fits are only part of model selection. We employ a Bayesian inference approach that quantifies model suitability by balancing closeness to data against both the number of model parameters and their a priori uncertainty. The penalty depends upon prior-to-calibration expectation of the viable range of values that model parameters might take, which we discuss as an essential aspect of the selection criterion. Models that are physically grounded are usually accompanied by tighter physical constraints on their respective parameters. The analysis reflects a basic principle: models grounded in physics can be expected to enjoy greater generality and perform better away from where they are calibrated. In contrast, purely empirical models can provide comparable fits, but the model selection framework penalizes their a priori uncertainty. We demonstrate the approach by selecting the best-justified number of modes in a Multi-mode Maxwell description of PVA-Borax. We also quantify relative merits of the Maxwell model relative to powerlaw fits and purely empirical fits for PVA-Borax, a viscoelastic liquid, and gluten.
NASA Technical Reports Server (NTRS)
Schoeberl, Mark; Rood, Richard B.; Hildebrand, Peter; Raymond, Carol
2003-01-01
The Earth System Model is the natural evolution of current climate models and will be the ultimate embodiment of our geophysical understanding of the planet. These models are constructed from components - atmosphere, ocean, ice, land, chemistry, solid earth, etc. models and merged together through a coupling program which is responsible for the exchange of data from the components. Climate models and future earth system models will have standardized modules, and these standards are now being developed by the ESMF project funded by NASA. The Earth System Model will have a variety of uses beyond climate prediction. The model can be used to build climate data records making it the core of an assimilation system, and it can be used in OSSE experiments to evaluate. The computing and storage requirements for the ESM appear to be daunting. However, the Japanese ES theoretical computing capability is already within 20% of the minimum requirements needed for some 2010 climate model applications. Thus it seems very possible that a focused effort to build an Earth System Model will achieve succcss.
Geochemical modeling: a review
Jenne, E.A.
1981-06-01
Two general families of geochemical models presently exist. The ion speciation-solubility group of geochemical models contain submodels to first calculate a distribution of aqueous species and to secondly test the hypothesis that the water is near equilibrium with particular solid phases. These models may or may not calculate the adsorption of dissolved constituents and simulate the dissolution and precipitation (mass transfer) of solid phases. Another family of geochemical models, the reaction path models, simulates the stepwise precipitation of solid phases as a result of reacting specified amounts of water and rock. Reaction path models first perform an aqueous speciation of the dissolved constituents of the water, test solubility hypotheses, then perform the reaction path modeling. Certain improvements in the present versions of these models would enhance their value and usefulness to applications in nuclear-waste isolation, etc. Mass-transfer calculations of limited extent are certainly within the capabilities of state-of-the-art models. However, the reaction path models require an expansion of their thermodynamic data bases and systematic validation before they are generally accepted.
Improved Screened Hydrogenic Model
Nishikawa, T.
1996-05-01
Screened Hydrogenic Model is widely used for energy level calculation in hydrodynamic code of inertial confinement fusion because Screened Hydrogenic Model is simple algebraic calculation. More{close_quote}s Screened Hydrogenic Model and his screening constants are usually used to calculate opacity and equation of state. By the use of his model, energy level can be consistently calculated with ion{close_quote}s total energy. But his model take into account the principal quantum number dependence only and cannot reproduce hydrogenic energy levels. As the precise experiment about opacity measurement is performed, it becomes clear that his model is not enough to use for opacity calculation. In this paper, his model is improved in the framework of Screened Hydrogenic Model. The improved model can reproduce the hydrogenic energy levels and include azimuthal quantum number dependence and the effect from another quantum state (a kind of inner quantum number). Screening constants are fitted by spectroscopic data and sophisticate calculations. By the use of improved model, energy levels are calculated more accurately for low-{ital z} ions. {copyright} {ital 1996 American Institute of Physics.}
[Mathematical models of hysteresis
Mayergoyz, I.D.
1991-01-01
The research described in this proposal is currently being supported by the US Department of Energy under the contract Mathematical Models of Hysteresis''. Thus, before discussing the proposed research in detail, it is worthwhile to describe and summarize the main results achieved in the course of our work under the above contract. Our ongoing research has largely been focused on the development of mathematical models of hysteretic nonlinearities with nonlocal memories''. The distinct feature of these nonlinearities is that their current states depend on past histories of input variations. It turns out that memories of hysteretic nonlinearities are quite selective. Indeed, experiments show that only some past input extrema leave their marks upon future states of hysteretic nonlinearities. Thus special mathematical tools are needed in order to describe nonlocal selective memories of hysteretic nonlinearities. Our research has been primarily concerned with Preisach-type models of hysteresis. All these models have a common generic feature; they are constructed as superpositions of simplest hysteretic nonlinearities-rectangular loops. Our study has by and large been centered around the following topics: various generalizations and extensions of the classical Preisach model, finding of necessary and sufficient conditions for the representation of actual hysteretic nonlinearities by various Preisach type models, solution of identification problems for these models, numerical implementation and experimental testing of Preisach type models. Although the study of Preisach type models has constituted the main direction of the research, some effort has also been made to establish some interesting connections between these models and such topics as: the critical state model for superconducting hysteresis, the classical Stoner-Wohlfarth model of vector magnetic hysteresis, thermal activation type models for viscosity, magnetostrictive hysteresis and neural networks.
Turbulence modeling and experiments
NASA Technical Reports Server (NTRS)
Shabbir, Aamir
1992-01-01
The best way of verifying turbulence is to do a direct comparison between the various terms and their models. The success of this approach depends upon the availability of the data for the exact correlations (both experimental and DNS). The other approach involves numerically solving the differential equations and then comparing the results with the data. The results of such a computation will depend upon the accuracy of all the modeled terms and constants. Because of this it is sometimes difficult to find the cause of a poor performance by a model. However, such a calculation is still meaningful in other ways as it shows how a complete Reynolds stress model performs. Thirteen homogeneous flows are numerically computed using the second order closure models. We concentrate only on those models which use a linear (or quasi-linear) model for the rapid term. This, therefore, includes the Launder, Reece and Rodi (LRR) model; the isotropization of production (IP) model; and the Speziale, Sarkar, and Gatski (SSG) model. Which of the three models performs better is examined along with what are their weaknesses, if any. The other work reported deal with the experimental balances of the second moment equations for a buoyant plume. Despite the tremendous amount of activity toward the second order closure modeling of turbulence, very little experimental information is available about the budgets of the second moment equations. Part of the problem stems from our inability to measure the pressure correlations. However, if everything else appearing in these equations is known from the experiment, pressure correlations can be obtained as the closing terms. This is the closest we can come to in obtaining these terms from experiment, and despite the measurement errors which might be present in such balances, the resulting information will be extremely useful for the turbulence modelers. The purpose of this part of the work was to provide such balances of the Reynolds stress and heat
Ray, T.R.
1993-01-01
Mathematical models are used to elucidate properties of the monomer-monomer and monomer-dimer type chemical reactions on a two-dimensional surface. The authors use mean-field and lattice gas models, detailing similarities and differences due to correlations in the lattice gas model. The monomer-monomer, or AB surface reaction model, with no diffusion, is investigated for various reaction rates k. Study of the exact rate equations reveals that poisoning always occurs if the adsorption rates of the reactants are unequal. If the adsorption rates of the reactants are equal, simulations show slow poisoning, associated with clustering of reactants. This behavior is also shown for the two-dimensional voter model. The authors analyze precisely the slow poisoning kinetics by an analytic treatment for the AB reaction with infinitesimal reaction rate, and by direct comparison with the voter model. They extend the results to incorporate the effects of place-exchange diffusion, and they compare the AB reaction with infinitesimal reaction rate and no diffusion to the voter model with diffusion at rate 1/2. They also consider the relationship of the voter model to the monomer-dimer model, and investigate the latter model for small reaction rates. The monomer-dimer, or AB[sub 2] surface reaction model is also investigated. Specifically, they consider the ZGB-model for CO-oxidation, and in generalizations of this model which include adspecies diffusion. A theory of nucleation to describe properties of non-equilibrium first-order transitions, specifically the evolution between [open quote]reactive[close quote] steady states and trivial adsorbing states, is derived. The behavior of the [open quote]epidemic[close quote] survival probability, P[sub s], for a non-poisoned patch surrounded by a poisoned background is determined below the poisoning transition.
Entanglement effect in polymer melts by Dissipative Particle Dynamics (DPD)
NASA Astrophysics Data System (ADS)
Khani, Shaghayegh; Maia, Joao
2015-03-01
Dissipative Particle Dynamics (DPD) is a mesoscale simulation method that has shown a very good potential in modeling different soft matter systems from colloidal suspensions to highly entangled polymers. Like any other simulation technique DPD is associated with some deficiencies, for instance in the case of entangled polymers soft repulsions used in DPD allow particle overlap which may result in topology violations that prevent the correct capturing of the entanglement effect. Therefore, in the present work in order to properly reproduce the dynamics and viscoelastic properties of polymers the soft repulsions between the particles are substituted with a repulsive potential between non-adjacent bonds of different FENE chains. Also, DPD is a coarse-grained simulation method that can be used to model time and length scales longer than atomistic models; however, due to the existence of an upper level limit for the level of coarse graining this method is not applicable for the whole mesoscopic range. Thus, this work represents a new approach for tuning the level of coarse-graining by adjusting the simulation parameters. The ability of the method in capturing the entanglement effects is validated by simulating dynamic and viscoelastic properties of polymers.
NASA Technical Reports Server (NTRS)
Hou, T. H.
1985-01-01
High quality long fiber reinforced composites, such as those used in aerospace and industrial applications, are commonly processed in autoclaves. An adequate resin flow model for the entire system (laminate/bleeder/breather), which provides a description of the time-dependent laminate consolidation process, is useful in predicting the loss of resin, heat transfer characteristics, fiber volume fraction and part dimension, etc., under a specified set of processing conditions. This could be accomplished by properly analyzing the flow patterns and pressure profiles inside the laminate during processing. A newly formulated resin flow model for composite prepreg lamination process is reported. This model considers viscous resin flows in both directions perpendicular and parallel to the composite plane. In the horizontal direction, a squeezing flow between two nonporous parallel plates is analyzed, while in the vertical direction, a poiseuille type pressure flow through porous media is assumed. Proper force and mass balances have been made and solved for the whole system. The effects of fiber-fiber interactions during lamination are included as well. The unique features of this analysis are: (1) the pressure gradient inside the laminate is assumed to be generated from squeezing action between two adjacent approaching fiber layers, and (2) the behavior of fiber bundles is simulated by a Finitely Extendable Nonlinear Elastic (FENE) spring.
NASA Astrophysics Data System (ADS)
Cruz, Filipe; Haward, Simon; Alves, Manuel; McKinley, Gareth
2014-11-01
We compare numerical and experimental results for viscoelastic flows in the optimized cross-slot extensional rheometer - OSCER (Haward et al., Phys. Rev. Lett. 109, 128301, 2012) up to the onset of elastically-driven flow instabilities. Model polymer solutions with almost constant shear viscosity are used in the experiments, and the FENE-CR constitutive model is used in the 2D numerical simulations together with an in-house finite-volume viscoelastic flow solver. We match the model parameters to the rheology of the fluids used in the experiments, and the simulations are conducted for a wide range of flow rates, ranging from Newtonian-like flow at low Weissenberg numbers (Wi) up to the onset of time-dependent elastic instabilities at high Wi. We test the applicability of a dimensionless stability criterion (McKinley et al., J Non-Newt Fluid Mech. 67, 19, 1996) for predicting the onset of flow instability for both the experimental and computational data sets, using a spatially-resolved procedure to locally compute the stability criterion in the vicinity of the stagnation point. By evaluating this dimensionless criterion on a pointwise basis we are able to clearly distinguish the OSCER flow geometry from the archetypal cross-slot geometry.
Generalized Multilevel Structural Equation Modeling
ERIC Educational Resources Information Center
Rabe-Hesketh, Sophia; Skrondal, Anders; Pickles, Andrew
2004-01-01
A unifying framework for generalized multilevel structural equation modeling is introduced. The models in the framework, called generalized linear latent and mixed models (GLLAMM), combine features of generalized linear mixed models (GLMM) and structural equation models (SEM) and consist of a response model and a structural model for the latent…
Modeling Imports in a Keynesian Expenditure Model
ERIC Educational Resources Information Center
Findlay, David W.
2010-01-01
The author discusses several issues that instructors of introductory macroeconomics courses should consider when introducing imports in the Keynesian expenditure model. The analysis suggests that the specification of the import function should partially, if not completely, be the result of a simple discussion about the spending and import…
Bobyn, Justin D; Little, David G; Gray, Randolph; Schindeler, Aaron
2015-04-01
Multiple techniques designed to induce scoliotic deformity have been applied across many animal species. We have undertaken a review of the literature regarding experimental models of scoliosis in animals to discuss their utility in comprehending disease aetiology and treatment. Models of scoliosis in animals can be broadly divided into quadrupedal and bipedal experiments. Quadrupedal models, in the absence of axial gravitation force, depend upon development of a mechanical asymmetry along the spine to initiate a scoliotic deformity. Bipedal models more accurately mimic human posture and consequently are subject to similar forces due to gravity, which have been long appreciated to be a contributing factor to the development of scoliosis. Many effective models of scoliosis in smaller animals have not been successfully translated to primates and humans. Though these models may not clarify the aetiology of human scoliosis, by providing a reliable and reproducible deformity in the spine they are a useful means with which to test interventions designed to correct and prevent deformity.
NASA Technical Reports Server (NTRS)
North, G. R.; Cahalan, R. F.; Coakley, J. A., Jr.
1981-01-01
An introductory survey of the global energy balance climate models is presented with an emphasis on analytical results. A sequence of increasingly complicated models involving ice cap and radiative feedback processes are solved, and the solutions and parameter sensitivities are studied. The model parameterizations are examined critically in light of many current uncertainties. A simple seasonal model is used to study the effects of changes in orbital elements on the temperature field. A linear stability theorem and a complete nonlinear stability analysis for the models are developed. Analytical solutions are also obtained for the linearized models driven by stochastic forcing elements. In this context the relation between natural fluctuation statistics and climate sensitivity is stressed.
David Chassin, Pavel Etingov
2013-04-30
The LMDT software automates the process of the load composite model data preparation in the format supported by the major power system software vendors (GE and Siemens). Proper representation of the load composite model in power system dynamic analysis is very important. Software tools for power system simulation like GE PSLF and Siemens PSSE already include algorithms for the load composite modeling. However, these tools require that the input information on composite load to be provided in custom formats. Preparation of this data is time consuming and requires multiple manual operations. The LMDT software enables to automate this process. Software is designed to generate composite load model data. It uses the default load composition data, motor information, and bus information as an input. Software processes the input information and produces load composition model. Generated model can be stored in .dyd format supported by GE PSLF package or .dyr format supported by Siemens PSSE package.
NASA Technical Reports Server (NTRS)
1985-01-01
The outside users payload model which is a continuation of documents and replaces and supersedes the July 1984 edition is presented. The time period covered by this model is 1985 through 2000. The following sections are included: (1) definition of the scope of the model; (2) discussion of the methodology used; (3) overview of total demand; (4) summary of the estimated market segmentation by launch vehicle; (5) summary of the estimated market segmentation by user type; (6) details of the STS market forecast; (7) summary of transponder trends; (8) model overview by mission category; and (9) detailed mission models. All known non-NASA, non-DOD reimbursable payloads forecast to be flown by non-Soviet-block countries are included in this model with the exception of Spacelab payloads and small self contained payloads. Certain DOD-sponsored or cosponsored payloads are included if they are reimbursable launches.
Extended frequency turbofan model
NASA Technical Reports Server (NTRS)
Mason, J. R.; Park, J. W.; Jaekel, R. F.
1980-01-01
The fan model was developed using two dimensional modeling techniques to add dynamic radial coupling between the core stream and the bypass stream of the fan. When incorporated into a complete TF-30 engine simulation, the fan model greatly improved compression system frequency response to planar inlet pressure disturbances up to 100 Hz. The improved simulation also matched engine stability limits at 15 Hz, whereas the one dimensional fan model required twice the inlet pressure amplitude to stall the simulation. With verification of the two dimensional fan model, this program formulated a high frequency F-100(3) engine simulation using row by row compression system characteristics. In addition to the F-100(3) remote splitter fan, the program modified the model fan characteristics to simulate a proximate splitter version of the F-100(3) engine.
Probabilistic Mesomechanical Fatigue Model
NASA Technical Reports Server (NTRS)
Tryon, Robert G.
1997-01-01
A probabilistic mesomechanical fatigue life model is proposed to link the microstructural material heterogeneities to the statistical scatter in the macrostructural response. The macrostructure is modeled as an ensemble of microelements. Cracks nucleation within the microelements and grow from the microelements to final fracture. Variations of the microelement properties are defined using statistical parameters. A micromechanical slip band decohesion model is used to determine the crack nucleation life and size. A crack tip opening displacement model is used to determine the small crack growth life and size. Paris law is used to determine the long crack growth life. The models are combined in a Monte Carlo simulation to determine the statistical distribution of total fatigue life for the macrostructure. The modeled response is compared to trends in experimental observations from the literature.
Introduction to Biological Models
2011-05-11
three steady states if NT > (dZ/αg) + (dP /µ), with a P,Z non-zero point being a stable attractor. NPZD The NPZ model assumes all dead organisms or...excreted material is immediately rem- ineralized to usable nutrient. In contrast, the NPZD model assumes that dead organisms and unassimilated...phytoplankton would contribute to a detrital pool that eventually be- 17 Figure 3: Schematic representation of NPZD model showing the fluxes of biomass and the
2014-09-04
Coastal Inlets Research Program Coastal Modeling System The work unit develops the Coastal Modeling System ( CMS ) and conducts basic research to...further understanding of sediment transport under mixed forcing from waves and currents. The CMS is a suite of coupled two- dimensional numerical...models for simulating waves, hydrodynamics, salinity and sediment transport, and morphology change. The CMS was identified by the USACE Hydraulics and
NASA Technical Reports Server (NTRS)
Hsu, H. M.
1980-01-01
A mesoscale numerical model of the Florida peninsula was formulated and applied to a dry, neutral atmosphere. The prospective use of the STAR-100 computer for the submesoscale model is discussed. The numerical model presented is tested under synoptically undisturbed conditions. Two cases, differing only in the direction of the prevailing geostrophic wind, are examined: a prevailing southwest wind and a prevailing southeast wind, both 6 m/sec at all levels initially.
HOMER® Micropower Optimization Model
Lilienthal, P.
2005-01-01
NREL has developed the HOMER micropower optimization model. The model can analyze all of the available small power technologies individually and in hybrid configurations to identify least-cost solutions to energy requirements. This capability is valuable to a diverse set of energy professionals and applications. NREL has actively supported its growing user base and developed training programs around the model. These activities are helping to grow the global market for solar technologies.
Bergen, Benjamin Karl
2016-07-07
This is the PDF of a powerpoint presentation from a teleconference on Los Alamos programming models. It starts by listing their assumptions for the programming models and then details a hierarchical programming model at the System Level and Node Level. Then it details how to map this to their internal nomenclature. Finally, a list is given of what they are currently doing in this regard.
Engel, D.W.; McGrail, B.P.
1993-11-01
The Office of Civilian Radioactive Waste Management and the Power Reactor and Nuclear Fuel Development Corporation of Japan (PNC) have supported the development of the Analytical Repository Source-Term (AREST) at Pacific Northwest Laboratory. AREST is a computer model developed to evaluate radionuclide release from an underground geologic repository. The AREST code can be used to calculate/estimate the amount and rate of each radionuclide that is released from the engineered barrier system (EBS) of the repository. The EBS is the man-made or disrupted area of the repository. AREST was designed as a system-level models to simulate the behavior of the total repository by combining process-level models for the release from an individual waste package or container. AREST contains primarily analytical models for calculating the release/transport of radionuclides to the lost rock that surrounds each waste package. Analytical models were used because of the small computational overhead that allows all the input parameters to be derived from a statistical distribution. Recently, a one-dimensional numerical model was also incorporated into AREST, to allow for more detailed modeling of the transport process with arbitrary length decay chains. The next step in modeling the EBS, is to develop a model that couples the probabilistic capabilities of AREST with a more detailed process model. This model will need to look at the reactive coupling of the processes that are involved with the release process. Such coupling would include: (1) the dissolution of the waste form, (2) the geochemical modeling of the groundwater, (3) the corrosion of the container overpacking, and (4) the backfill material, just to name a few. Several of these coupled processes are already incorporated in the current version of AREST.
NASA Technical Reports Server (NTRS)
2000-01-01
Dr. Marc Pusey (seated) and Dr. Craig Kundrot use computers to analyze x-ray maps and generate three-dimensional models of protein structures. With this information, scientists at Marshall Space Flight Center can learn how proteins are made and how they work. The computer screen depicts a proten structure as a ball-and-stick model. Other models depict the actual volume occupied by the atoms, or the ribbon-like structures that are crucial to a protein's function.
Atmospheric prediction model survey
NASA Technical Reports Server (NTRS)
Wellck, R. E.
1976-01-01
As part of the SEASAT Satellite program of NASA, a survey of representative primitive equation atmospheric prediction models that exist in the world today was written for the Jet Propulsion Laboratory. Seventeen models developed by eleven different operational and research centers throughout the world are included in the survey. The surveys are tutorial in nature describing the features of the various models in a systematic manner.
Young, Michael F.
2015-07-01
Aerosol particles that deposit on surfaces may be subsequently resuspended by air flowing over the surface. A review of models for this liftoff process is presented and compared to available data. Based on this review, a model that agrees with existing data and is readily computed is presented for incorporation into a system level code such as MELCOR. Liftoff Model for MELCOR July 2015 4 This page is intentionally blank
Open source molecular modeling.
Pirhadi, Somayeh; Sunseri, Jocelyn; Koes, David Ryan
2016-09-01
The success of molecular modeling and computational chemistry efforts are, by definition, dependent on quality software applications. Open source software development provides many advantages to users of modeling applications, not the least of which is that the software is free and completely extendable. In this review we categorize, enumerate, and describe available open source software packages for molecular modeling and computational chemistry. An updated online version of this catalog can be found at https://opensourcemolecularmodeling.github.io.
NASA Technical Reports Server (NTRS)
Kerstman, Eric; Minard, Charles; Saile, Lynn; Freiere deCarvalho, Mary; Myers, Jerry; Walton, Marlei; Butler, Douglas; Iyengar, Sriram; Johnson-Throop, Kathy; Baumann, David
2010-01-01
The goals of the Integrated Medical Model (IMM) are to develop an integrated, quantified, evidence-based decision support tool useful to crew health and mission planners and to help align science, technology, and operational activities intended to optimize crew health, safety, and mission success. Presentation slides address scope and approach, beneficiaries of IMM capabilities, history, risk components, conceptual models, development steps, and the evidence base. Space adaptation syndrome is used to demonstrate the model's capabilities.
NASA Astrophysics Data System (ADS)
Arnaoudova, Kristina; Stanchev, Peter
2015-11-01
The business processes are the key asset for every organization. The design of the business process models is the foremost concern and target among an organization's functions. Business processes and their proper management are intensely dependent on the performance of software applications and technology solutions. The paper is attempt for definition of new Conceptual model of IT service provider, it could be examined as IT focused Enterprise model, part of Enterprise Architecture (EA) school.
Compositional Modeling with DPNs
2007-11-02
Technical Report Compositional Modeling with DPNs 6. AUTHOR(S) Geoffrey Zweig and Stuart Russell 7. PERFORMING ORGANIZATION NAMES(S) AND ADDRESS(ES...Standard Form 298 (Rev. 2-89) Prescribed by ANSI Std. 239-18 298-102 Compositional Modeling With DPNs Geoffrey Zweig Stuart Russell Report No. UCB...Modeling With DPNs Geoffrey Zweig * Stuart Russell * Sept. 8, 1997 Abstract Dynamic probabilistic networks (DPNs) are a powerful and efficient method for
Numerical Modeling Experiments
1974-09-01
presence of clouds is associated with the occurvence of condensation in the atmospheric models. Cloudiness 3t a particulat grid point is introduced -4...when saturation is predicted as a result of either large-scale moisture flux convergence or vertical convective adjustment. In most models such clouds ... cloud top, cloud thickness, and liquid-water content. In some general circulation models the local fractional convective cloud amountv tre taken
Kim, Hyung Do
2006-11-28
We consider gauge messenger models in which X and Y gauge bosons and gauginos are messengers of supersymmetry breaking. In simple gauge messenger models, all the soft parameters except {mu} and B{mu} are calculated in terms of a single scale parameter MSUSY which is proportional to F / MGUT. Unique prediction on dark matter in gauge messenger models is discussed. (Based on hep-ph/0601036 and hep-ph/0607169)
Guidelines for Model Evaluation.
1979-01-01
by a decisionmaker. The full-scale evaluation of a complex model can be an expensive, time- consuming effort requiring diverse talents and skills...relative to PIES, were documented in a report to the Congress. 2/ An important side- effect of that document was that a foundation was laid for model...while for model evaluation there are no generally accepted standards or methods. Hence, GAO perceives the need to expand upon the lessons learned in
Global Atmospheric Aerosol Modeling
NASA Technical Reports Server (NTRS)
Hendricks, Johannes; Aquila, Valentina; Righi, Mattia
2012-01-01
Global aerosol models are used to study the distribution and properties of atmospheric aerosol particles as well as their effects on clouds, atmospheric chemistry, radiation, and climate. The present article provides an overview of the basic concepts of global atmospheric aerosol modeling and shows some examples from a global aerosol simulation. Particular emphasis is placed on the simulation of aerosol particles and their effects within global climate models.
Rat Endovascular Perforation Model
Sehba, Fatima A.
2014-01-01
Experimental animal models of aneurysmal subarachnoid hemorrhage (SAH) have provided a wealth of information on the mechanisms of brain injury. The Rat endovascular perforation model (EVP) replicates the early pathophysiology of SAH and hence is frequently used to study early brain injury following SAH. This paper presents a brief review of historical development of the EVP model, details the technique used to create SAH and considerations necessary to overcome technical challenges. PMID:25213427
NASA Technical Reports Server (NTRS)
Wallerstein, D. V.; Lahey, R. S.; Haggenmacher, G. W.
1977-01-01
Many of the practical aspects and problems of ensuring the integrity of a structural model are discussed, as well as the steps which have been taken in the NASTRAN system to assure that these checks can be routinely performed. Model integrity as used applies not only to the structural model but also to the loads applied to the model. Emphasis is also placed on the fact that when dealing with substructure analysis, all of the checking procedures discussed should be applied at the lowest level of substructure prior to any coupling.
NASA Technical Reports Server (NTRS)
Briggs, Hugh C.
2008-01-01
An error budget is a commonly used tool in design of complex aerospace systems. It represents system performance requirements in terms of allowable errors and flows these down through a hierarchical structure to lower assemblies and components. The requirements may simply be 'allocated' based upon heuristics or experience, or they may be designed through use of physics-based models. This paper presents a basis for developing an error budget for models of the system, as opposed to the system itself. The need for model error budgets arises when system models are a principle design agent as is increasingly more common for poorly testable high performance space systems.
Photovoltaic array performance model.
Kratochvil, Jay A.; Boyson, William Earl; King, David L.
2004-08-01
This document summarizes the equations and applications associated with the photovoltaic array performance model developed at Sandia National Laboratories over the last twelve years. Electrical, thermal, and optical characteristics for photovoltaic modules are included in the model, and the model is designed to use hourly solar resource and meteorological data. The versatility and accuracy of the model has been validated for flat-plate modules (all technologies) and for concentrator modules, as well as for large arrays of modules. Applications include system design and sizing, 'translation' of field performance measurements to standard reporting conditions, system performance optimization, and real-time comparison of measured versus expected system performance.
Railway switch transport model.
Horvat, Martin; Prosen, Tomaž; Benenti, Giuliano; Casati, Giulio
2012-11-01
We propose a simple model of coupled heat and particle transport based on zero-dimensional classical deterministic dynamics, which is reminiscent of a railway switch whose action is a function only of the particle's energy. It is shown that already in the minimal three-terminal model, where the second terminal is considered as a probe with zero net particle and heat currents, one can find extremely asymmetric Onsager matrices as a consequence of time-reversal symmetry breaking of the model. This minimalistic transport model provides a better understanding of thermoelectric heat engines in the presence of time-reversal symmetry breaking.
Brown-VanHoozer, S. A.
1999-06-02
Conscious awareness of our environment is based on a feedback loop comprised of sensory input transmitted to the central nervous system leading to construction of our ''model of the world,'' (Lewis et al, 1982). We then assimilate the neurological model at the unconscious level into information we can later consciously consider useful in identifying belief systems and behaviors for designing diverse systems. Thus, we can avoid potential problems based on our open-to-error perceived reality of the world. By understanding how our model of reality is organized, we allow ourselves to transcend content and develop insight into how effective choices and belief systems are generated through sensory derived processes. These are the processes which provide the designer the ability to meta model (build a model of a model) the user; consequently, matching the mental model of the user with that of the designer's and, coincidentally, forming rapport between the two participants. The information shared between the participants is neither assumed nor generalized, it is closer to equivocal; thus minimizing error through a sharing of each other's model of reality. How to identify individual mental mechanisms or processes, how to organize the individual strategies of these mechanisms into useful patterns, and to formulate these into models for success and knowledge based outcomes is the subject of the discussion that follows.
Lightning return stroke models
NASA Technical Reports Server (NTRS)
Lin, Y. T.; Uman, M. A.; Standler, R. B.
1980-01-01
We test the two most commonly used lightning return stroke models, Bruce-Golde and transmission line, against subsequent stroke electric and magnetic field wave forms measured simultaneously at near and distant stations and show that these models are inadequate to describe the experimental data. We then propose a new return stroke model that is physically plausible and that yields good approximations to the measured two-station fields. Using the new model, we derive return stroke charge and current statistics for about 100 subsequent strokes.
NASA Technical Reports Server (NTRS)
Sapyta, Joe; Reid, Hank; Walton, Lew
1993-01-01
The topics are presented in viewgraph form and include the following: particle bed reactor (PBR) core cross section; PBR bleed cycle; fuel and moderator flow paths; PBR modeling requirements; characteristics of PBR and nuclear thermal propulsion (NTP) modeling; challenges for PBR and NTP modeling; thermal hydraulic computer codes; capabilities for PBR/reactor application; thermal/hydralic codes; limitations; physical correlations; comparison of predicted friction factor and experimental data; frit pressure drop testing; cold frit mask factor; decay heat flow rate; startup transient simulation; and philosophy of systems modeling.
NASA Technical Reports Server (NTRS)
Levy, R.; Mcginness, H.
1976-01-01
Investigations were performed to predict the power available from the wind at the Goldstone, California, antenna site complex. The background for power prediction was derived from a statistical evaluation of available wind speed data records at this location and at nearby locations similarly situated within the Mojave desert. In addition to a model for power prediction over relatively long periods of time, an interim simulation model that produces sample wind speeds is described. The interim model furnishes uncorrelated sample speeds at hourly intervals that reproduce the statistical wind distribution at Goldstone. A stochastic simulation model to provide speed samples representative of both the statistical speed distributions and correlations is also discussed.
Multifamily Envelope Leakage Model
Faakye, O.; Griffiths, D.
2015-05-01
The objective of the 2013 research project was to develop the model for predicting fully guarded test results (FGT), using unguarded test data and specific building features of apartment units. The model developed has a coefficient of determination R2 value of 0.53 with a root mean square error (RMSE) of 0.13. Both statistical metrics indicate that the model is relatively strong. When tested against data that was not included in the development of the model, prediction accuracy was within 19%, which is reasonable given that seasonal differences in blower door measurements can vary by as much as 25%.
Modelling urban snowmelt runoff
NASA Astrophysics Data System (ADS)
Valeo, C.; Ho, C. L. I.
2004-12-01
Few investigations have been made into modelling snowmelt in urban areas; hence, current urban snowmelt routines have adopted parameters and approaches intended for rural areas that are not appropriate in an urban environment. This paper examines problems with current urban snowmelt models and proposes a model that uses parameters developed from field studies focusing exclusively on urban snow. The Urban Snow Model (USM) uses an energy balance scheme at an hourly time step, changes in urban snow albedo, and incorporates eight different types of redistributed snow cover. USM is tested against observed flow data from a small residential community located in Calgary, Alberta. The degree-day method for snowmelt, the SWMM model, and a modified version of USM that incorporates a partial energy budget scheme relying only on net radiation, are also tested against the observed flow data. The full energy budget version of USM outperformed all other models in terms of time to peak, peak flowrate and model efficiency; however, the modified version of USM fared quite well and is recommended when a lack of data exists. The degree-day method and the SWMM models fared poorly and were unable to simulate peak flowrates in most cases. The tests also demonstrated the need to distribute snow into appropriate snow covers in order to simulate peak flowrates accurately and provide good model efficiency.
Computer Modeling and Simulation
Pronskikh, V. S.
2014-05-09
Verification and validation of computer codes and models used in simulation are two aspects of the scientific practice of high importance and have recently been discussed by philosophers of science. While verification is predominantly associated with the correctness of the way a model is represented by a computer code or algorithm, validation more often refers to model’s relation to the real world and its intended use. It has been argued that because complex simulations are generally not transparent to a practitioner, the Duhem problem can arise for verification and validation due to their entanglement; such an entanglement makes it impossible to distinguish whether a coding error or model’s general inadequacy to its target should be blamed in the case of the model failure. I argue that in order to disentangle verification and validation, a clear distinction between computer modeling (construction of mathematical computer models of elementary processes) and simulation (construction of models of composite objects and processes by means of numerical experimenting with them) needs to be made. Holding on to that distinction, I propose to relate verification (based on theoretical strategies such as inferences) to modeling and validation, which shares the common epistemology with experimentation, to simulation. To explain reasons of their intermittent entanglement I propose a weberian ideal-typical model of modeling and simulation as roles in practice. I suggest an approach to alleviate the Duhem problem for verification and validation generally applicable in practice and based on differences in epistemic strategies and scopes
Evolutionary financial market models
NASA Astrophysics Data System (ADS)
Ponzi, A.; Aizawa, Y.
2000-12-01
We study computer simulations of two financial market models, the second a simplified model of the first. The first is a model of the self-organized formation and breakup of crowds of traders, motivated by the dynamics of competitive evolving systems which shows interesting self-organized critical (SOC)-type behaviour without any fine tuning of control parameters. This SOC-type avalanching and stasis appear as realistic volatility clustering in the price returns time series. The market becomes highly ordered at ‘crashes’ but gradually loses this order through randomization during the intervening stasis periods. The second model is a model of stocks interacting through a competitive evolutionary dynamic in a common stock exchange. This model shows a self-organized ‘market-confidence’. When this is high the market is stable but when it gets low the market may become highly volatile. Volatile bursts rapidly increase the market confidence again. This model shows a phase transition as temperature parameter is varied. The price returns time series in the transition region is very realistic power-law truncated Levy distribution with clustered volatility and volatility superdiffusion. This model also shows generally positive stock cross-correlations as is observed in real markets. This model may shed some light on why such phenomena are observed.
Radiation Environment Modeling for Spacecraft Design: New Model Developments
NASA Technical Reports Server (NTRS)
Barth, Janet; Xapsos, Mike; Lauenstein, Jean-Marie; Ladbury, Ray
2006-01-01
A viewgraph presentation on various new space radiation environment models for spacecraft design is described. The topics include: 1) The Space Radiatio Environment; 2) Effects of Space Environments on Systems; 3) Space Radiatio Environment Model Use During Space Mission Development and Operations; 4) Space Radiation Hazards for Humans; 5) "Standard" Space Radiation Environment Models; 6) Concerns about Standard Models; 7) Inadequacies of Current Models; 8) Development of New Models; 9) New Model Developments: Proton Belt Models; 10) Coverage of New Proton Models; 11) Comparison of TPM-1, PSB97, AP-8; 12) New Model Developments: Electron Belt Models; 13) Coverage of New Electron Models; 14) Comparison of "Worst Case" POLE, CRESELE, and FLUMIC Models with the AE-8 Model; 15) New Model Developments: Galactic Cosmic Ray Model; 16) Comparison of NASA, MSU, CIT Models with ACE Instrument Data; 17) New Model Developmemts: Solar Proton Model; 18) Comparison of ESP, JPL91, KIng/Stassinopoulos, and PSYCHIC Models; 19) New Model Developments: Solar Heavy Ion Model; 20) Comparison of CREME96 to CREDO Measurements During 2000 and 2002; 21) PSYCHIC Heavy ion Model; 22) Model Standardization; 23) Working Group Meeting on New Standard Radiation Belt and Space Plasma Models; and 24) Summary.
Convergence of a Moran model to Eigen's quasispecies model.
Dalmau, Joseba
2017-03-02
We prove that a Moran model converges in probability to Eigen's quasispecies model in the infinite population limit. We show further that the invariant probability measure of the Moran model converges to the unique stationary solution of Eigen's quasispecies model.
Anisotropic exchange-interaction model: From the Potts model to the exchange-interaction model
NASA Astrophysics Data System (ADS)
King, T. C.; Chen, H. H.
1995-04-01
A spin model called the anisotropic exchange-interaction model is proposed. The Potts model, the exchange-interaction model, and the spin-1/2 anisotropic Heisenberg model are special cases of the proposed model. Thermodynamic properties of the model on the bcc and the fcc lattices are determined by the constant-coupling approximation.
NASA Astrophysics Data System (ADS)
Bahr, Benjamin; Hellmann, Frank; Kamiński, Wojciech; Kisielowski, Marcin; Lewandowski, Jerzy
2011-05-01
The goal of this paper is to introduce a systematic approach to spin foams. We define operator spin foams, that is foams labelled by group representations and operators, as our main tool. A set of moves we define in the set of the operator spin foams (among other operations) allows us to split the faces and the edges of the foams. We assign to each operator spin foam a contracted operator, by using the contractions at the vertices and suitably adjusted face amplitudes. The emergence of the face amplitudes is the consequence of assuming the invariance of the contracted operator with respect to the moves. Next, we define spin foam models and consider the class of models assumed to be symmetric with respect to the moves we have introduced, and assuming their partition functions (state sums) are defined by the contracted operators. Briefly speaking, those operator spin foam models are invariant with respect to the cellular decomposition, and are sensitive only to the topology and colouring of the foam. Imposing an extra symmetry leads to a family we call natural operator spin foam models. This symmetry, combined with assumed invariance with respect to the edge splitting move, determines a complete characterization of a general natural model. It can be obtained by applying arbitrary (quantum) constraints on an arbitrary BF spin foam model. In particular, imposing suitable constraints on a spin(4) BF spin foam model is exactly the way we tend to view 4D quantum gravity, starting with the BC model and continuing with the Engle-Pereira-Rovelli-Livine (EPRL) or Freidel-Krasnov (FK) models. That makes our framework directly applicable to those models. Specifically, our operator spin foam framework can be translated into the language of spin foams and partition functions. Among our natural spin foam models there are the BF spin foam model, the BC model, and a model corresponding to the EPRL intertwiners. Our operator spin foam framework can also be used for more general spin
Magretta, Joan
2002-05-01
"Business model" was one of the great buzz-words of the Internet boom. A company didn't need a strategy, a special competence, or even any customers--all it needed was a Web-based business model that promised wild profits in some distant, ill-defined future. Many people--investors, entrepreneurs, and executives alike--fell for the fantasy and got burned. And as the inevitable counterreaction played out, the concept of the business model fell out of fashion nearly as quickly as the .com appendage itself. That's a shame. As Joan Magretta explains, a good business model remains essential to every successful organization, whether it's a new venture or an established player. To help managers apply the concept successfully, she defines what a business model is and how it complements a smart competitive strategy. Business models are, at heart, stories that explain how enterprises work. Like a good story, a robust business model contains precisely delineated characters, plausible motivations, and a plot that turns on an insight about value. It answers certain questions: Who is the customer? How do we make money? What underlying economic logic explains how we can deliver value to customers at an appropriate cost? Every viable organization is built on a sound business model, but a business model isn't a strategy, even though many people use the terms interchangeably. Business models describe, as a system, how the pieces of a business fit together. But they don't factor in one critical dimension of performance: competition. That's the job of strategy. Illustrated with examples from companies like American Express, EuroDisney, WalMart, and Dell Computer, this article clarifies the concepts of business models and strategy, which are fundamental to every company's performance.
Biosphere Process Model Report
J. Schmitt
2000-05-25
To evaluate the postclosure performance of a potential monitored geologic repository at Yucca Mountain, a Total System Performance Assessment (TSPA) will be conducted. Nine Process Model Reports (PMRs), including this document, are being developed to summarize the technical basis for each of the process models supporting the TSPA model. These reports cover the following areas: (1) Integrated Site Model; (2) Unsaturated Zone Flow and Transport; (3) Near Field Environment; (4) Engineered Barrier System Degradation, Flow, and Transport; (5) Waste Package Degradation; (6) Waste Form Degradation; (7) Saturated Zone Flow and Transport; (8) Biosphere; and (9) Disruptive Events. Analysis/Model Reports (AMRs) contain the more detailed technical information used to support TSPA and the PMRs. The AMRs consists of data, analyses, models, software, and supporting documentation that will be used to defend the applicability of each process model for evaluating the postclosure performance of the potential Yucca Mountain repository system. This documentation will ensure the traceability of information from its source through its ultimate use in the TSPA-Site Recommendation (SR) and in the National Environmental Policy Act (NEPA) analysis processes. The objective of the Biosphere PMR is to summarize (1) the development of the biosphere model, and (2) the Biosphere Dose Conversion Factors (BDCFs) developed for use in TSPA. The Biosphere PMR does not present or summarize estimates of potential radiation doses to human receptors. Dose calculations are performed as part of TSPA and will be presented in the TSPA documentation. The biosphere model is a component of the process to evaluate postclosure repository performance and regulatory compliance for a potential monitored geologic repository at Yucca Mountain, Nevada. The biosphere model describes those exposure pathways in the biosphere by which radionuclides released from a potential repository could reach a human receptor
Steady States and Dynamics of 2-D Nematic Polymers Driven by an Imposed Weak Shear
2007-01-01
f (0)(θ,T0,T1) is a quasi-steady state if it is independent of T0. In particu- lar , the phase angle α in (4.3) is independent of T0. However, as we...posedness for the dumbbell model of polymeric fluids, Comm. Math. Phys., 248, 409-427, 2004. [11] I. Fatkullin and V. Slastikov, A note on the Onsager ...model of nematic phase transitions, Commun. Math. Sci., 3, 21-26, 2005. [12] I. Fatkullin and V. Slastikov, Critical points of the Onsager functional
NASA Astrophysics Data System (ADS)
Datar, V. M.; Chakrabarty, D. R.; Kumar, Suresh; Nanal, V.; Pastore, S.; Wiringa, R. B.; Behera, S. P.; Chatterjee, A.; Jenkins, D.; Lister, C. J.; Mirgule, E. T.; Mitra, A.; Pillay, R. G.; Ramachandran, K.; Roberts, O. J.; Rout, P. C.; Shrivastava, A.; Sugathan, P.
2013-08-01
An earlier measurement on the 4+ to 2+ radiative transition in Be8 provided the first electromagnetic signature of its dumbbell-like shape. However, the large uncertainty in the measured cross section does not allow a stringent test of nuclear structure models. This Letter reports a more elaborate and precise measurement for this transition, via the radiative capture in the He4+He4 reaction, improving the accuracy by about a factor of 3. Ab initio calculations of the radiative transition strength with improved three-nucleon forces are also presented. The experimental results are compared with the predictions of the alpha cluster model and ab initio calculations.
Bayesian Data-Model Fit Assessment for Structural Equation Modeling
ERIC Educational Resources Information Center
Levy, Roy
2011-01-01
Bayesian approaches to modeling are receiving an increasing amount of attention in the areas of model construction and estimation in factor analysis, structural equation modeling (SEM), and related latent variable models. However, model diagnostics and model criticism remain relatively understudied aspects of Bayesian SEM. This article describes…
Spiral model pilot project information model
NASA Technical Reports Server (NTRS)
1991-01-01
The objective was an evaluation of the Spiral Model (SM) development approach to allow NASA Marshall to develop an experience base of that software management methodology. A discussion is presented of the Information Model (IM) that was used as part of the SM methodology. A key concept of the SM is the establishment of an IM to be used by management to track the progress of a project. The IM is the set of metrics that is to be measured and reported throughout the life of the project. These metrics measure both the product and the process to ensure the quality of the final delivery item and to ensure the project met programmatic guidelines. The beauty of the SM, along with the IM, is the ability to measure not only the correctness of the specification and implementation of the requirements but to also obtain a measure of customer satisfaction.
SWMM is a model for urban hydrology. It has a long history and is relied upon by professional engineers in the US and around the world. SWMM provides both gray and green Infrastructure modeling capabilities. As such, it is a convenient tool for understanding the tradeoff between ...
Thom, Ronald M.; Judd, Chaeli
2007-07-27
Successful restoration of wetland habitats depends on both our understanding of our system and our ability to characterize it. By developing a conceptual model, looking at different spatial scales and integrating diverse data streams: GIS datasets and NASA products, we were able to develop a dynamic model for site prioritization based on both qualitative and quantitative relationships found in the coastal environment.
NASA Astrophysics Data System (ADS)
Morrison, Margaret
2014-02-01
When James Clerk Maxwell set out his famous equations 150 years ago, his model of electromagnetism included a piece of pure fiction: an invisible, all-pervasive "aether" made up of elastic vortices separated by electric charges. Margaret Morrison explores how this and other "fictional" models shape science.
Automated Student Model Improvement
ERIC Educational Resources Information Center
Koedinger, Kenneth R.; McLaughlin, Elizabeth A.; Stamper, John C.
2012-01-01
Student modeling plays a critical role in developing and improving instruction and instructional technologies. We present a technique for automated improvement of student models that leverages the DataShop repository, crowd sourcing, and a version of the Learning Factors Analysis algorithm. We demonstrate this method on eleven educational…
ERIC Educational Resources Information Center
Mahalik, James R.
1990-01-01
Presents and evaluates four systematic eclectic models of psychotherapy: Beutler's eclectic psychotherapy; Howard, Nance, and Myers' adaptive counseling and therapy; Lazarus' multimodal therapy; and Prochaska and DiClemente's transtheoretical approach. Examines support for these models and makes conceptual and empirical recommendations.…
ERIC Educational Resources Information Center
Miles, David T.; Robinson, Roger E.
The General Teaching Model is a procedural guide for the design, implementation, evaluation, and improvement of instruction. The Model is considered applicable to all levels of education, all subject matters, and any length of instructional unit. It consists of four components: 1) instructional objectives, 2) pre-assessment, 3) instructional…
The Teacher Improvement Model.
ERIC Educational Resources Information Center
Pokalo, Mariann
The Teacher Improvement Model was begun as an Organizational Development Project using the parallel systems approach in a school for emotionally disturbed junior high school students. Teachers volunteered for committee work and requested observations and evaluations in an effort to define and establish a discipline model best suited to them. Such…
Modeling Biomimetic Mineralization
2010-03-02
combination of computational methods including Molecular Dynamics, Langevin Dynamics, and Monte Carlo, and theories including statistical mechanics and...treated by a combination of computational methods including Molecular Dynamics, Langevin Dynamics, and Monte Carlo, and theories including...at the interfaces are neglected in our computer modeling so far. Force-field Molecular model Molecular dynamics Langevin dynamics Brownian
ERIC Educational Resources Information Center
Baker, William P.; Moore, Cathy Ronstadt
1998-01-01
Understanding antibody structure and function is difficult for many students. The rearrangement of constant and variable regions during antibody differentiation can be effectively simulated using a paper model. Describes a hands-on laboratory exercise which allows students to model antibody diversity using readily available resources. (PVD)
ERIC Educational Resources Information Center
Gabel, Dorothy; And Others
1992-01-01
Chemistry can be described on three levels: sensory, molecular, and symbolic. Proposes a particle approach to teaching chemistry that uses magnets to aid students construct molecular models and solve particle problems. Includes examples of Johnstone's model of chemistry phenomena, a problem worksheet, and a student concept mastery sheet. (MDH)
Validation of mesoscale models
NASA Technical Reports Server (NTRS)
Kuo, Bill; Warner, Tom; Benjamin, Stan; Koch, Steve; Staniforth, Andrew
1993-01-01
The topics discussed include the following: verification of cloud prediction from the PSU/NCAR mesoscale model; results form MAPS/NGM verification comparisons and MAPS observation sensitivity tests to ACARS and profiler data; systematic errors and mesoscale verification for a mesoscale model; and the COMPARE Project and the CME.
Acid rain: Microphysical model
NASA Technical Reports Server (NTRS)
Dingle, A. N.
1980-01-01
A microphysical model was used to simulate the case of a ground cloud without dilution by entrainment and without precipitation. The numerical integration techniques of the model are presented. The droplet size spectra versus time and the droplet molalities for each value of time are discussed.
ERIC Educational Resources Information Center
Parks, Melissa
2014-01-01
Model-eliciting activities (MEAs) are not new to those in engineering or mathematics, but they were new to Melissa Parks. Model-eliciting activities are simulated real-world problems that integrate engineering, mathematical, and scientific thinking as students find solutions for specific scenarios. During this process, students generate solutions…
ERIC Educational Resources Information Center
Flannery, Maura C.
1997-01-01
Addresses the most popular models currently being chosen for biological research and the reasons behind those choices. Among the current favorites are zebra fish, fruit flies, mice, monkeys, and yeast. Concludes with a brief examination of the ethical issues involved, and why some animals may need to be replaced in research with model systems.…
Writing Models, Versatile Writers.
ERIC Educational Resources Information Center
VanDeWeghe, Richard
1983-01-01
Presents five research-based writing models to help student writers analyze their composition processes: (1) discovery, (2) direct writing process, (3) five-stage process, (4) write-talk-write, and (5) four key questions. Discusses advantages and disadvantages of each model. (PD)
ERIC Educational Resources Information Center
Morgan, Gwen
Models of state involvement in training child care providers are briefly discussed and the employers' role in training is explored. Six criteria for states that are taken as models are identified, and four are described. Various state activities are described for each criterion. It is noted that little is known about employer and other private…
Rotorwash Operational Footprint Modeling
2014-07-01
lower drag coefficient . The developed analytical model for predicting unbalance is shown to correlate relatively well with the test data. This model... coefficients and exponents within the equations. Correlation of RoWFoot to flight test data is fundamental to quantitatively trying to determine the...using empirically derived coefficients and exponents through feedback from an iterative flight test correlation process. Rotorwash Operational
pylightcurve: Exoplanet lightcurve model
NASA Astrophysics Data System (ADS)
Tsiaras, A.; Waldmann, I. P.; Rocchetto, M.; Varley, R.; Morello, G.; Damiano, M.; Tinetti, G.
2016-12-01
pylightcurve is a model for light-curves of transiting planets. It uses the four coefficients law for the stellar limb darkening and returns the relative flux, F(t), as a function of the limb darkening coefficients, an, the Rp/R* ratio and all the orbital parameters based on the nonlinear limb darkening model (Claret 2000).
Legal Policy Optimizing Models
ERIC Educational Resources Information Center
Nagel, Stuart; Neef, Marian
1977-01-01
The use of mathematical models originally developed by economists and operations researchers is described for legal process research. Situations involving plea bargaining, arraignment, and civil liberties illustrate the applicability of decision theory, inventory modeling, and linear programming in operations research. (LBH)
NASA Technical Reports Server (NTRS)
Zhu, Zhifan
2016-01-01
Under the NASA-KAIA-KARI ATM research collaboration agreement, SOSS ICN Model has been developed for Incheon International Airport. This presentation describes the model validation work in the project. The presentation will show the results and analysis of the validation.
Reliability model generator specification
NASA Technical Reports Server (NTRS)
Cohen, Gerald C.; Mccann, Catherine
1990-01-01
The Reliability Model Generator (RMG), a program which produces reliability models from block diagrams for ASSIST, the interface for the reliability evaluation tool SURE is described. An account is given of motivation for RMG and the implemented algorithms are discussed. The appendices contain the algorithms and two detailed traces of examples.
Computer Model Documentation Guide.
ERIC Educational Resources Information Center
National Bureau of Standards (DOC), Washington, DC. Inst. for Computer Sciences and Technology.
These guidelines for communicating effectively the details of computer model design and operation to persons with varying interests in a model recommend the development of four different types of manuals to meet the needs of managers, users, analysts and programmers. The guidelines for preparing a management summary manual suggest a broad spectrum…
Modeling the Teaching Consultant.
ERIC Educational Resources Information Center
Johnson, Brian L.; And Others
1990-01-01
Discusses the teaching consultant process in computer programing courses, describes a teaching consultant model from both the teachers' and students' perspectives, and shows how this model can be used to develop an intelligent teaching consultant (ITC). Differences between this collection of expert systems and conventional intelligent tutoring…
ERIC Educational Resources Information Center
Linacre, John M.
Determination of the intentions of the test developer is fundamental to the choice of the analytical model for a rating scale. For confirmatory analysis, the developer's intentions inform the choice of the general form of the model, representing the manner in which the respondent interacts with the scale; these intentions also inform the choice of…
ERIC Educational Resources Information Center
Ivie, Stanley D.
2007-01-01
Humanity delights in spinning conceptual models of the world. These models, in turn, mirror their respective root metaphors. Three root metaphors--spiritual, organic, and mechanical--have dominated western thought. The spiritual metaphor runs from Plato, through Hegel, and connects with Montessori. The organic metaphor extends from Aristotle,…
NASA Astrophysics Data System (ADS)
Perelson, Alan; Conway, Jessica; Cao, Youfang
A large effort is being made to find a means to cure HIV infection. I will present a dynamical model of post-treatment control (PTC) or ``functional cure'' of HIV-infection. Some patients treated with suppressive antiviral therapy have been taken off of therapy and then spontaneously control HIV infection such that the amount of virus in the circulation is maintained undetectable by clinical assays for years. The model explains PTC occurring in some patients by having a parameter regime in which the model exhibits bistability, with both a low and high steady state viral load being stable. The model makes a number of predictions about how to attain the low PTC steady state. Bistability in this model depends upon the immune response becoming exhausted when over stimulated. I will also present a generalization of the model in which immunotherapy can be used to reverse immune exhaustion and compare model predictions with experiments in SIV infected macaques given immunotherapy and then taken off of antiretroviral therapy. Lastly, if time permits, I will discuss one of the hurdles to true HIV eradication, latently infected cells, and present clinical trial data and a new model addressing pharmacological means of flushing out the latent reservoir. Supported by NIH Grants AI028433 and OD011095.
NASA Astrophysics Data System (ADS)
Erpylev, N. P.; Smirnov, M. A.; Bagrov, A. V.
A night sky model is proposed. It includes different components of light polution, such as solar twilight, moon scattered light, zodiacal light, Milky Way, air glow and artificial light pollution. The model is designed for calculating the efficiency of astronomical installations.
PROSTATE REGULATION: MODELING ENDOGENOUS ...
Prostate function is an important indicator of androgen status in toxicological studies making predictive modeling of the relevant pharmacokinetics and pharmacodynamics desirable. Prostate function is an important indicator of androgen status in toxicological studies making predictive modeling of the relevant pharmacokinetics and pharmacodynamics desirable.
ERIC Educational Resources Information Center
Journal of Science and Mathematics Education in Southeast Asia, 1981
1981-01-01
Instructions (with diagrams and parts list) are provided for constructing an eye model with a pliable lens made from a plastic bottle which can vary its convexity to accommodate changing positions of an object being viewed. Also discusses concepts which the model can assist in developing. (Author/SK)
Barchet, W.R. ); Dennis, R.L. ); Seilkop, S.K. ); Banic, C.M.; Davies, D.; Hoff, R.M.; Macdonald, A.M.; Mickle, R.E.; Padro, J.; Puckett, K. ); Byun, D.; McHenry, J.N.
1991-12-01
The binational Eulerian Model Evaluation Field Study (EMEFS) consisted of several coordinated data gathering and model evaluation activities. In the EMEFS, data were collected by five air and precipitation monitoring networks between June 1988 and June 1990. Model evaluation is continuing. This interim report summarizes the progress made in the evaluation of the Regional Acid Deposition Model (RADM) and the Acid Deposition and Oxidant Model (ADOM) through the December 1990 completion of a State of Science and Technology report on model evaluation for the National Acid Precipitation Assessment Program (NAPAP). Because various assessment applications of RADM had to be evaluated for NAPAP, the report emphasizes the RADM component of the evaluation. A protocol for the evaluation was developed by the model evaluation team and defined the observed and predicted values to be used and the methods by which the observed and predicted values were to be compared. Scatter plots and time series of predicted and observed values were used to present the comparisons graphically. Difference statistics and correlations were used to quantify model performance. 64 refs., 34 figs., 6 tabs.
ERIC Educational Resources Information Center
Watt, James H., Jr.
Pointing out that linear causal models can organize the interrelationships of a large number of variables, this paper contends that such models are particularly useful to mass communication research, which must by necessity deal with complex systems of variables. The paper first outlines briefly the philosophical requirements for establishing a…
ERIC Educational Resources Information Center
Dworkin, Nancy; Dworkin, Yehoash
The 1978 Summer Reading Institute, which served 58 Washington, D.C., elementary school children, is described in this paper. Major characteristics of the program model are first identified, along with elements that were added to the model in the preplanning stage. Numerous aspects of the program are then described, including the make-up of the…
Jacob J. Jacobson; Gretchen Matthern
2007-04-01
System Dynamics is a computer-aided approach to evaluating the interrelationships of different components and activities within complex systems. Recently, System Dynamics models have been developed in areas such as policy design, biological and medical modeling, energy and the environmental analysis, and in various other areas in the natural and social sciences. The real power of System Dynamic modeling is gaining insights into total system behavior as time, and system parameters are adjusted and the effects are visualized in real time. System Dynamic models allow decision makers and stakeholders to explore long-term behavior and performance of complex systems, especially in the context of dynamic processes and changing scenarios without having to wait decades to obtain field data or risk failure if a poor management or design approach is used. The Idaho National Laboratory recently has been developing a System Dynamic model of the US Nuclear Fuel Cycle. The model is intended to be used to identify and understand interactions throughout the entire nuclear fuel cycle and suggest sustainable development strategies. This paper describes the basic framework of the current model and presents examples of useful insights gained from the model thus far with respect to sustainable development of nuclear power.
Teaching Mathematical Modelling.
ERIC Educational Resources Information Center
Jones, Mark S.
1997-01-01
Outlines a course at the University of Glamorgan in the United Kingdom in which a computer algebra system (CAS) teaches mathematical modeling. The format is based on continual assessment of group and individual work stating the problem, a feature list, and formulation of the models. No additional mathematical word processing package is necessary.…
Computational Modeling of Tires
NASA Technical Reports Server (NTRS)
Noor, Ahmed K. (Compiler); Tanner, John A. (Compiler)
1995-01-01
This document contains presentations and discussions from the joint UVA/NASA Workshop on Computational Modeling of Tires. The workshop attendees represented NASA, the Army and Air force, tire companies, commercial software developers, and academia. The workshop objectives were to assess the state of technology in the computational modeling of tires and to provide guidelines for future research.
Connectionist Modelling and Education.
ERIC Educational Resources Information Center
Evers, Colin W.
2000-01-01
Provides a detailed, technical introduction to the state of cognitive science research, in particular the rise of the "new cognitive science," especially artificial neural net (ANN) models. Explains one influential ANN model and describes diverse applications and their implications for education. (EV)
Model for Contingency Contracting.
ERIC Educational Resources Information Center
Prince George's Community Coll., Largo, MD. Dept. of Human Development.
The Department of Human Development at Prince George's Community College has developed a contingency contracting model for the department's counseling and student services which presents planning and evaluation as interrelated parts of the same process of self-imposed accountability. The implementation of the model consisted of: (1) planning…
Structural Equation Model Trees
ERIC Educational Resources Information Center
Brandmaier, Andreas M.; von Oertzen, Timo; McArdle, John J.; Lindenberger, Ulman
2013-01-01
In the behavioral and social sciences, structural equation models (SEMs) have become widely accepted as a modeling tool for the relation between latent and observed variables. SEMs can be seen as a unification of several multivariate analysis techniques. SEM Trees combine the strengths of SEMs and the decision tree paradigm by building tree…
Anticipatory model of cavitation
NASA Astrophysics Data System (ADS)
Kercel, Stephen W.; Allgood, Glenn O.; Dress, William B.; Hylton, James O.
1999-03-01
The Anticipatory System (AS) formalism developed by Robert Rosen provides some insight into the problem of embedding intelligent behavior in machines. AS emulates the anticipatory behavior of biological systems. AS bases its behavior on its expectations about the near future and those expectations are modified as the system gains experience. The expectation is based on an internal model that is drawn from an appeal to physical reality. To be adaptive, the model must be able to update itself. To be practical, the model must run faster than real-time. The need for a physical model and the requirement that the model execute at extreme speeds, has held back the application of AS to practical problems. Two recent advances make it possible to consider the use of AS for practical intelligent sensors. First, advances in transducer technology make it possible to obtain previously unavailable data from which a model can be derived. For example, acoustic emissions (AE) can be fed into a Bayesian system identifier that enables the separation of a weak characterizing signal, such as the signature of pump cavitation precursors, from a strong masking signal, such as a pump vibration feature. The second advance is the development of extremely fast, but inexpensive, digital signal processing hardware on which it is possible to run an adaptive Bayesian-derived model faster than real-time. This paper reports the investigation of an AS using a model of cavitation based on hydrodynamic principles and Bayesian analysis of data from high-performance AE sensors.
ERIC Educational Resources Information Center
New Mexico Univ., Albuquerque. American Indian Law Center.
The Model Children's Code was developed to provide a legally correct model code that American Indian tribes can use to enact children's codes that fulfill their legal, cultural and economic needs. Code sections cover the court system, jurisdiction, juvenile offender procedures, minor-in-need-of-care, and termination. Almost every Code section is…
NASA Technical Reports Server (NTRS)
Sellers, Piers
2012-01-01
Model results will be reviewed to assess different methods for bounding the terrestrial role in the global carbon cycle. It is proposed that a series of climate model runs could be scoped that would tighten the limits on the "missing sink" of terrestrial carbon and could also direct future satellite image analyses to search for its geographical location and understand its seasonal dynamics.
ERIC Educational Resources Information Center
Buggey, Tom; Ogle, Lindsey
2012-01-01
Video self-modeling (VSM) first appeared on the psychology and education stage in the early 1970s. The practical applications of VSM were limited by lack of access to tools for editing video, which is necessary for almost all self-modeling videos. Thus, VSM remained in the research domain until the advent of camcorders and VCR/DVD players and,…
ERIC Educational Resources Information Center
Zwaan, Rolf A.; Madden, Carol J.
2004-01-01
The authors examined how situation models are updated during text comprehension. If comprehenders keep track of the evolving situation, they should update their models such that the most current information, the here and now, is more available than outdated information. Contrary to this updating hypothesis, E. J. O'Brien, M. L. Rizzella, J. E.…
NASA Astrophysics Data System (ADS)
Rutten, R. J.
2002-12-01
This contribution honoring Kees de Jager's 80th birthday is a review of "one-dimensional" solar atmosphere modeling that followed on the initial "Utrecht Reference Photosphere" of Heintze, Hubenet & de Jager (1964). My starting point is the Bilderberg conference, convened by de Jager in 1967 at the time when NLTE radiative transfer theory became mature. The resulting Bilderberg model was quickly superseded by the HSRA and later by the VAL-FAL sequence of increasingly sophisticated NLTE continuum-fitting models from Harvard. They became the "standard models" of solar atmosphere physics, but Holweger's relatively simple LTE line-fitting model still persists as a favorite of solar abundance determiners. After a brief model inventory I discuss subsequent work on the major modeling issues (coherency, NLTE, dynamics) listed as to-do items by de Jager in 1968. The present conclusion is that one-dimensional modeling recovers Schwarzschild's (1906) finding that the lower solar atmosphere is grosso modo in radiative equilibrium. This is a boon for applications regarding the solar atmosphere as one-dimensional stellar example - but the real sun, including all the intricate phenomena that now constitute the mainstay of solar physics, is vastly more interesting.
Animal models for osteoporosis
NASA Technical Reports Server (NTRS)
Turner, R. T.; Maran, A.; Lotinun, S.; Hefferan, T.; Evans, G. L.; Zhang, M.; Sibonga, J. D.
2001-01-01
Animal models will continue to be important tools in the quest to understand the contribution of specific genes to establishment of peak bone mass and optimal bone architecture, as well as the genetic basis for a predisposition toward accelerated bone loss in the presence of co-morbidity factors such as estrogen deficiency. Existing animal models will continue to be useful for modeling changes in bone metabolism and architecture induced by well-defined local and systemic factors. However, there is a critical unfulfilled need to develop and validate better animal models to allow fruitful investigation of the interaction of the multitude of factors which precipitate senile osteoporosis. Well characterized and validated animal models that can be recommended for investigation of the etiology, prevention and treatment of several forms of osteoporosis have been listed in Table 1. Also listed are models which are provisionally recommended. These latter models have potential but are inadequately characterized, deviate significantly from the human response, require careful choice of strain or age, or are not practical for most investigators to adopt. It cannot be stressed strongly enough that the enormous potential of laboratory animals as models for osteoporosis can only be realized if great care is taken in the choice of an appropriate species, age, experimental design, and measurements. Poor choices will results in misinterpretation of results which ultimately can bring harm to patients who suffer from osteoporosis by delaying advancement of knowledge.
This lecture will present AQUATOX, an aquatic ecosystem simulation model developed by Dr. Dick Park and supported by the U.S. EPA. The AQUATOX model predicts the fate of various pollutants, such as nutrients and organic chemicals, and their effects on the ecosystem, including fi...
Modelling University Governance
ERIC Educational Resources Information Center
Trakman, Leon
2008-01-01
Twentieth century governance models used in public universities are subject to increasing doubt across the English-speaking world. Governments question if public universities are being efficiently governed; if their boards of trustees are adequately fulfilling their trust obligations towards multiple stakeholders; and if collegial models of…
ERIC Educational Resources Information Center
Ifenthaler, Dirk; Seel, Norbert M.
2013-01-01
In this paper, there will be a particular focus on mental models and their application to inductive reasoning within the realm of instruction. A basic assumption of this study is the observation that the construction of mental models and related reasoning is a slowly developing capability of cognitive systems that emerges effectively with proper…
NASA Technical Reports Server (NTRS)
Knezovich, F. M.
1976-01-01
A modular structured system of computer programs is presented utilizing earth and ocean dynamical data keyed to finitely defined parameters. The model is an assemblage of mathematical algorithms with an inherent capability of maturation with progressive improvements in observational data frequencies, accuracies and scopes. The Eom in its present state is a first-order approach to a geophysical model of the earth's dynamics.
Unitary Response Regression Models
ERIC Educational Resources Information Center
Lipovetsky, S.
2007-01-01
The dependent variable in a regular linear regression is a numerical variable, and in a logistic regression it is a binary or categorical variable. In these models the dependent variable has varying values. However, there are problems yielding an identity output of a constant value which can also be modelled in a linear or logistic regression with…
On Some Electroconvection Models
NASA Astrophysics Data System (ADS)
Constantin, Peter; Elgindi, Tarek; Ignatova, Mihaela; Vicol, Vlad
2017-02-01
We consider a model of electroconvection motivated by studies of the motion of a two-dimensional annular suspended smectic film under the influence of an electric potential maintained at the boundary by two electrodes. We prove that this electroconvection model has global in time unique smooth solutions.
ERIC Educational Resources Information Center
Fischbein, Efraim
2001-01-01
Analyses several examples of tacit influences exerted by mental models on the interpretation of various mathematical concepts in the domain of actual infinity. Specifically addresses the unconscious effect of the figural-pictorial models of statements related to the infinite sets of geometrical points related to the concepts of function and…
NASA Astrophysics Data System (ADS)
Taniguchi, Tadahiro; Sawaragi, Tetsuo
In this paper, a new machine-learning method, called Dual-Schemata model, is presented. Dual-Schemata model is a kind of self-organizational machine learning methods for an autonomous robot interacting with an unknown dynamical environment. This is based on Piaget's Schema model, that is a classical psychological model to explain memory and cognitive development of human beings. Our Dual-Schemata model is developed as a computational model of Piaget's Schema model, especially focusing on sensori-motor developing period. This developmental process is characterized by a couple of two mutually-interacting dynamics; one is a dynamics formed by assimilation and accommodation, and the other dynamics is formed by equilibration and differentiation. By these dynamics schema system enables an agent to act well in a real world. This schema's differentiation process corresponds to a symbol formation process occurring within an autonomous agent when it interacts with an unknown, dynamically changing environment. Experiment results obtained from an autonomous facial robot in which our model is embedded are presented; an autonomous facial robot becomes able to chase a ball moving in various ways without any rewards nor teaching signals from outside. Moreover, emergence of concepts on the target movements within a robot is shown and discussed in terms of fuzzy logics on set-subset inclusive relationships.
ERIC Educational Resources Information Center
Eichinger, John
2005-01-01
Models are crucial to science teaching and learning, yet they can create unforeseen and overlooked challenges for students and teachers. For example, consider the time-tested clay volcano that relies on a vinegar and-baking-soda mixture for its "eruption." Based on a classroom demonstration of that geologic model, elementary students may interpret…
Australia's Next Top Fraction Model
ERIC Educational Resources Information Center
Gould, Peter
2013-01-01
Peter Gould suggests Australia's next top fraction model should be a linear model rather than an area model. He provides a convincing argument and gives examples of ways to introduce a linear model in primary classrooms.
General background on modeling and specifics of modeling vapor intrusion are given. Three classical model applications are described and related to the problem of petroleum vapor intrusion. These indicate the need for model calibration and uncertainty analysis. Evaluation of Bi...
Brozoski, Thomas J; Bauer, Carol A
2016-08-01
Presented is a thematic review of animal tinnitus models from a functional perspective. Chronic tinnitus is a persistent subjective sound sensation, emergent typically after hearing loss. Although the sensation is experientially simple, it appears to have central a nervous system substrate of unexpected complexity that includes areas outside of those classically defined as auditory. Over the past 27 years animal models have significantly contributed to understanding tinnitus' complex neurophysiology. In that time, a diversity of models have been developed, each with its own strengths and limitations. None has clearly become a standard. Animal models trace their origin to the 1988 experiments of Jastreboff and colleagues. All subsequent models derive some of their features from those experiments. Common features include behavior-dependent psychophysical determination, acoustic conditions that contrast objective sound and silence, and inclusion of at least one normal-hearing control group. In the present review, animal models have been categorized as either interrogative or reflexive. Interrogative models use emitted behavior under voluntary control to indicate hearing. An example would be pressing a lever to obtain food in the presence of a particular sound. In this type of model animals are interrogated about their auditory sensations, analogous to asking a patient, "What do you hear?" These models require at least some training and motivation management, and reflect the perception of tinnitus. Reflexive models, in contrast, employ acoustic modulation of an auditory reflex, such as the acoustic startle response. An unexpected loud sound will elicit a reflexive motor response from many species, including humans. Although involuntary, acoustic startle can be modified by a lower-level preceding event, including a silent sound gap. Sound-gap modulation of acoustic startle appears to discriminate tinnitus in animals as well as humans, and requires no training or
Droplet formation in a flow focusing configuration: Effects of viscoelasticity
NASA Astrophysics Data System (ADS)
Nooranidoost, Mohammad; Izbassarov, Daulet; Muradoglu, Metin
2016-12-01
We numerically investigate the effects of bulk fluid viscoelasticity on droplet formation and dynamics in an axisymmetric flow focusing configuration. Viscoelasticity is modeled using the finitely extensible nonlinear elastic-Chilcott-Rallison (FENE-CR) model. Extensive simulations are performed to examine droplet formation and breakup dynamics for a wide range of parameters including flow rate ratio, Weissenberg number, polymeric viscosity ratio, and extensibility parameter. It is found that these parameters have a significant influence on the droplet size and size distribution (dispersity). Three different regimes are observed in the sequence of squeezing, dripping, and jetting modes as the flow rate ratio is increased. It is also found that the viscoelasticity has a similar effect as decreasing flow rate ratio and acts to delay transition from squeezing to dripping and from dripping to jetting regimes. The strain-rate hardening occurs at a critical Weissenberg number resulting in an abrupt increase in droplet size and this effect is more pronounced as the polymeric viscosity ratio is increased.
Dissipative particle dynamics simulation for the density currents of polymer fluids
NASA Astrophysics Data System (ADS)
Li, Yanggui; Geng, Xingguo; Liu, Zhijun; Liu, Qingsheng; Ouyang, Jie
2016-11-01
In this work, the two-dimensional lock-exchange density currents of polymer fluids are numerically investigated using dissipative particle dynamics (DPD) at the mesoscale particle level. A modified finitely extensible nonlinear elastic (FENE) chain model is chosen to describe the polymer system, which perfectly depicts not only the elastic tension but also the elastic repulsion between the adjacent beads with bond length as the equilibrium length of one segment. Through the model and numerical simulation, we analyze the dynamics behavior of the density currents of polymer fluids. A comparison with its Newtonian counterpart suggests that the interface between two polymer fluids is more smoothed, and the front structure is different from the Newtonian case because the Kelvin-Helmholtz instability and cleft instability are suppressed by the polymer. Besides, we also probe the influences of polymer volume concentration, chain length and extensibility on the density currents. These simulation results show that increasing any of the parameters, concentration, chain length, and extensibility, the inhibiting effect of polymer on the density currents becomes more significant.
NASA Technical Reports Server (NTRS)
Brown, R. G.
1984-01-01
The formulation of appropriate state-space models for Kalman filtering applications is studied. The so-called model is completely specified by four matrix parameters and the initial conditions of the recursive equations. Once these are determined, the die is cast, and the way in which the measurements are weighted is determined foreverafter. Thus, finding a model that fits the physical situation at hand is all important. Also, it is often the most difficult aspect of designing a Kalman filter. Formulation of discrete state models from the spectral density and ARMA random process descriptions is discussed. Finally, it is pointed out that many common processes encountered in applied work (such as band-limited white noise) simply do not lend themselves very well to Kalman filter modeling.
Linear models: permutation methods
Cade, B.S.; Everitt, B.S.; Howell, D.C.
2005-01-01
Permutation tests (see Permutation Based Inference) for the linear model have applications in behavioral studies when traditional parametric assumptions about the error term in a linear model are not tenable. Improved validity of Type I error rates can be achieved with properly constructed permutation tests. Perhaps more importantly, increased statistical power, improved robustness to effects of outliers, and detection of alternative distributional differences can be achieved by coupling permutation inference with alternative linear model estimators. For example, it is well-known that estimates of the mean in linear model are extremely sensitive to even a single outlying value of the dependent variable compared to estimates of the median [7, 19]. Traditionally, linear modeling focused on estimating changes in the center of distributions (means or medians). However, quantile regression allows distributional changes to be estimated in all or any selected part of a distribution or responses, providing a more complete statistical picture that has relevance to many biological questions [6]...
V. Chipman
2002-10-31
The purpose of the Ventilation Model is to simulate the heat transfer processes in and around waste emplacement drifts during periods of forced ventilation. The model evaluates the effects of emplacement drift ventilation on the thermal conditions in the emplacement drifts and surrounding rock mass, and calculates the heat removal by ventilation as a measure of the viability of ventilation to delay the onset of peak repository temperature and reduce its magnitude. The heat removal by ventilation is temporally and spatially dependent, and is expressed as the fraction of heat carried away by the ventilation air compared to the fraction of heat produced by radionuclide decay. One minus the heat removal is called the wall heat fraction, or the remaining amount of heat that is transferred via conduction to the surrounding rock mass. Downstream models, such as the ''Multiscale Thermohydrologic Model'' (BSC 2001), use the wall heat fractions as outputted from the Ventilation Model to initialize their postclosure analyses.
NASA Technical Reports Server (NTRS)
Parke, M. E.
1978-01-01
Two trends evident in global tidal modelling since the first GEOP conference in 1972 are described. The first centers on the incorporation of terms for ocean loading and gravitational self attraction into Laplace's tidal equations. The second centers on a better understanding of the problem of near resonant modelling and the need for realistic maps of tidal elevation for use by geodesists and geophysicists. Although new models still show significant differences, especially in the South Atlantic, there are significant similarities in many of the world's oceans. This allows suggestions to be made for future locations for bottom pressure gauge measurements. Where available, estimates of M2 tidal dissipation from the new models are significantly lower than estimates from previous models.
Stratiform chromite deposit model
Schulte, Ruth F.; Taylor, Ryan D.; Piatak, Nadine M.; Seal, Robert R., II
2010-01-01
Stratiform chromite deposits are of great economic importance, yet their origin and evolution remain highly debated. Layered igneous intrusions such as the Bushveld, Great Dyke, Kemi, and Stillwater Complexes, provide opportunities for studying magmatic differentiation processes and assimilation within the crust, as well as related ore-deposit formation. Chromite-rich seams within layered intrusions host the majority of the world's chromium reserves and may contain significant platinum-group-element (PGE) mineralization. This model of stratiform chromite deposits is part of an effort by the U.S. Geological Survey's Mineral Resources Program to update existing models and develop new descriptive mineral deposit models to supplement previously published models for use in mineral-resource and mineral-environmental assessments. The model focuses on features that may be common to all stratiform chromite deposits as a way to gain insight into the processes that gave rise to their emplacement and to the significant economic resources contained in them.
Molecular modeling of peptides.
Kuczera, Krzysztof
2015-01-01
This article presents a review of the field of molecular modeling of peptides. The main focus is on atomistic modeling with molecular mechanics potentials. The description of peptide conformations and solvation through potentials is discussed. Several important computer simulation methods are briefly introduced, including molecular dynamics, accelerated sampling approaches such as replica-exchange and metadynamics, free energy simulations and kinetic network models like Milestoning. Examples of recent applications for predictions of structure, kinetics, and interactions of peptides with complex environments are described. The reliability of current simulation methods is analyzed by comparison of computational predictions obtained using different models with each other and with experimental data. A brief discussion of coarse-grained modeling and future directions is also presented.
Fidelis, K; Adzhubej, A; Kryshtafovych, A; Daniluk, P
2005-02-23
The phenomenal success of the genome sequencing projects reveals the power of completeness in revolutionizing biological science. Currently it is possible to sequence entire organisms at a time, allowing for a systemic rather than fractional view of their organization and the various genome-encoded functions. There is an international plan to move towards a similar goal in the area of protein structure. This will not be achieved by experiment alone, but rather by a combination of efforts in crystallography, NMR spectroscopy, and computational modeling. Only a small fraction of structures are expected to be identified experimentally, the remainder to be modeled. Presently there is no organized infrastructure to critically evaluate and present these data to the biological community. The goal of the Protein Model Database project is to create such infrastructure, including (1) public database of theoretically derived protein structures; (2) reliable annotation of protein model quality, (3) novel structure analysis tools, and (4) access to the highest quality modeling techniques available.
NASA Technical Reports Server (NTRS)
Badler, N. I.; Lee, P.; Wong, S.
1985-01-01
Strength modeling is a complex and multi-dimensional issue. There are numerous parameters to the problem of characterizing human strength, most notably: (1) position and orientation of body joints; (2) isometric versus dynamic strength; (3) effector force versus joint torque; (4) instantaneous versus steady force; (5) active force versus reactive force; (6) presence or absence of gravity; (7) body somatotype and composition; (8) body (segment) masses; (9) muscle group envolvement; (10) muscle size; (11) fatigue; and (12) practice (training) or familiarity. In surveying the available literature on strength measurement and modeling an attempt was made to examine as many of these parameters as possible. The conclusions reached at this point toward the feasibility of implementing computationally reasonable human strength models. The assessment of accuracy of any model against a specific individual, however, will probably not be possible on any realistic scale. Taken statistically, strength modeling may be an effective tool for general questions of task feasibility and strength requirements.
Cardiovascular modeling and diagnostics
Kangas, L.J.; Keller, P.E.; Hashem, S.; Kouzes, R.T.
1995-12-31
In this paper, a novel approach to modeling and diagnosing the cardiovascular system is introduced. A model exhibits a subset of the dynamics of the cardiovascular behavior of an individual by using a recurrent artificial neural network. Potentially, a model will be incorporated into a cardiovascular diagnostic system. This approach is unique in that each cardiovascular model is developed from physiological measurements of an individual. Any differences between the modeled variables and the variables of an individual at a given time are used for diagnosis. This approach also exploits sensor fusion to optimize the utilization of biomedical sensors. The advantage of sensor fusion has been demonstrated in applications including control and diagnostics of mechanical and chemical processes.
Integrated Workforce Modeling System
NASA Technical Reports Server (NTRS)
Moynihan, Gary P.
2000-01-01
There are several computer-based systems, currently in various phases of development at KSC, which encompass some component, aspect, or function of workforce modeling. These systems may offer redundant capabilities and/or incompatible interfaces. A systems approach to workforce modeling is necessary in order to identify and better address user requirements. This research has consisted of two primary tasks. Task 1 provided an assessment of existing and proposed KSC workforce modeling systems for their functionality and applicability to the workforce planning function. Task 2 resulted in the development of a proof-of-concept design for a systems approach to workforce modeling. The model incorporates critical aspects of workforce planning, including hires, attrition, and employee development.
J.M. Scaglione
2003-03-12
The purpose of the ''Criticality Model Report'' is to validate the MCNP (CRWMS M&O 1998h) code's ability to accurately predict the effective neutron multiplication factor (k{sub eff}) for a range of conditions spanned by various critical configurations representative of the potential configurations commercial reactor assemblies stored in a waste package may take. Results of this work are an indication of the accuracy of MCNP for calculating eigenvalues, which will be used as input for criticality analyses for spent nuclear fuel (SNF) storage at the proposed Monitored Geologic Repository. The scope of this report is to document the development and validation of the criticality model. The scope of the criticality model is only applicable to commercial pressurized water reactor fuel. Valid ranges are established as part of the validation of the criticality model. This model activity follows the description in BSC (2002a).
Hubbard, W. B.; Militzer, B.
2016-03-20
In anticipation of new observational results for Jupiter's axial moment of inertia and gravitational zonal harmonic coefficients from the forthcoming Juno orbiter, we present a number of preliminary Jupiter interior models. We combine results from ab initio computer simulations of hydrogen–helium mixtures, including immiscibility calculations, with a new nonperturbative calculation of Jupiter's zonal harmonic coefficients, to derive a self-consistent model for the planet's external gravity and moment of inertia. We assume helium rain modified the interior temperature and composition profiles. Our calculation predicts zonal harmonic values to which measurements can be compared. Although some models fit the observed (pre-Juno) second- and fourth-order zonal harmonics to within their error bars, our preferred reference model predicts a fourth-order zonal harmonic whose absolute value lies above the pre-Juno error bars. This model has a dense core of about 12 Earth masses and a hydrogen–helium-rich envelope with approximately three times solar metallicity.
NASA Astrophysics Data System (ADS)
Watanabe, Shigeto; Kumamoto, Atsushi; Kakinami, Yoshihiro
2016-07-01
begin{center} {bf Modeling of Plasmasphere} end{center} Electron density at altitudes below 10,000km is estimated from upper-hybrid resonance (UHR) emission observed by the plasma wave and sounder experiments (PWS) on Akebono satellite from February 22, 1989 to April 23, 2015. The electron density of plasmasphere is investigated statistically and compared with International Reference Ionosphere model. We have made an empirical model of electron density of plasmasphere at altitudes between 1000 km and 10000 km. The electron density distribution is also compared with a physical model (Plasmasphere Thermosphere model: PTM) developed in Japan. The electron densities by the Akebono satellite and the PTM show clearly density gradient change at altitude of 1500 km and plasmapause. The density gradient change at 1500 km altitude is corresponding to transition height from O+ to H+. The electron density distribution of plasmasphere shows clearly local time, latitude, season, solar activity and magnetic activity dependences.
Jones, Katherine A.; Finley, Patrick D.; Moore, Thomas W.; Nozick, Linda Karen; Martin, Nathaniel; Bandlow, Alisa; Detry, Richard Joseph; Evans, Leland B.; Berger, Taylor Eugen
2013-09-01
Infectious diseases can spread rapidly through healthcare facilities, resulting in widespread illness among vulnerable patients. Computational models of disease spread are useful for evaluating mitigation strategies under different scenarios. This report describes two infectious disease models built for the US Department of Veteran Affairs (VA) motivated by a Varicella outbreak in a VA facility. The first model simulates disease spread within a notional contact network representing staff and patients. Several interventions, along with initial infection counts and intervention delay, were evaluated for effectiveness at preventing disease spread. The second model adds staff categories, location, scheduling, and variable contact rates to improve resolution. This model achieved more accurate infection counts and enabled a more rigorous evaluation of comparative effectiveness of interventions.
NASA Technical Reports Server (NTRS)
North, G. R.; Crowley, T. J.
1984-01-01
Mathematical climate modelling has matured as a discipline to the point that it is useful in paleoclimatology. As an example a new two dimensional energy balance model is described and applied to several problems of current interest. The model includes the seasonal cycle and the detailed land-sea geographical distribution. By examining the changes in the seasonal cycle when external perturbations are forced upon the climate system it is possible to construct hypotheses about the origin of midlatitude ice sheets and polar ice caps. In particular the model predicts a rather sudden potential for glaciation over large areas when the Earth's orbital elements are only slightly altered. Similarly, the drift of continents or the change of atmospheric carbon dioxide over geological time induces radical changes in continental ice cover. With the advance of computer technology and improved understanding of the individual components of the climate system, these ideas will be tested in far more realistic models in the near future.
Conditional statistical model building
NASA Astrophysics Data System (ADS)
Hansen, Mads Fogtmann; Hansen, Michael Sass; Larsen, Rasmus
2008-03-01
We present a new statistical deformation model suited for parameterized grids with different resolutions. Our method models the covariances between multiple grid levels explicitly, and allows for very efficient fitting of the model to data on multiple scales. The model is validated on a data set consisting of 62 annotated MR images of Corpus Callosum. One fifth of the data set was used as a training set, which was non-rigidly registered to each other without a shape prior. From the non-rigidly registered training set a shape prior was constructed by performing principal component analysis on each grid level and using the results to construct a conditional shape model, conditioning the finer parameters with the coarser grid levels. The remaining shapes were registered with the constructed shape prior. The dice measures for the registration without prior and the registration with a prior were 0.875 +/- 0.042 and 0.8615 +/- 0.051, respectively.
Newville, Matthew
The XAFS Model Compound Library contains XAFS data on model compounds. The term "model" compounds refers to compounds of homogeneous and well-known crystallographic or molecular structure. Each data file in this library has an associated atoms.inp file that can be converted to a feff.inp file using the program ATOMS. (See the related Searchable Atoms.inp Archive at http://cars9.uchicago.edu/~newville/adb/) This Library exists because XAFS data on model compounds is useful for several reasons, including comparing to unknown data for "fingerprinting" and testing calculations and analysis methods. The collection here is currently limited, but is growing. The focus to date has been on inorganic compounds and minerals of interest to the geochemical community. [Copied, with editing, from http://cars9.uchicago.edu/~newville/ModelLib/
Hughes, T.J.; Fastook, J.L.
1994-05-01
The University of Maine conducted this study for Pacific Northwest Laboratory (PNL) as part of a global climate modeling task for site characterization of the potential nuclear waste respository site at Yucca Mountain, NV. The purpose of the study was to develop a global ice sheet dynamics model that will forecast the three-dimensional configuration of global ice sheets for specific climate change scenarios. The objective of the third (final) year of the work was to produce ice sheet data for glaciation scenarios covering the next 100,000 years. This was accomplished using both the map-plane and flowband solutions of our time-dependent, finite-element gridpoint model. The theory and equations used to develop the ice sheet models are presented. Three future scenarios were simulated by the model and results are discussed.
Peskin, M.E.
1997-05-01
These lectures constitute a short course in ``Beyond the Standard Model`` for students of experimental particle physics. The author discusses the general ideas which guide the construction of models of physics beyond the Standard model. The central principle, the one which most directly motivates the search for new physics, is the search for the mechanism of the spontaneous symmetry breaking observed in the theory of weak interactions. To illustrate models of weak-interaction symmetry breaking, the author gives a detailed discussion of the idea of supersymmetry and that of new strong interactions at the TeV energy scale. He discusses experiments that will probe the details of these models at future pp and e{sup +}e{sup {minus}} colliders.
Pupo, Amaury; Baez-Nieto, David; Martínez, Agustín; Latorre, Ramón; González, Carlos
2014-01-01
Voltage-gated proton channels are integral membrane proteins with the capacity to permeate elementary particles in a voltage and pH dependent manner. These proteins have been found in several species and are involved in various physiological processes. Although their primary topology is known, lack of details regarding their structures in the open conformation has limited analyses toward a deeper understanding of the molecular determinants of their function and regulation. Consequently, the function-structure relationships have been inferred based on homology models. In the present work, we review the existing proton channel models, their assumptions, predictions and the experimental facts that support them. Modeling proton channels is not a trivial task due to the lack of a close homolog template. Hence, there are important differences between published models. This work attempts to critically review existing proton channel models toward the aim of contributing to a better understanding of the structural features of these proteins. PMID:24755912
Maximally Expressive Task Modeling
NASA Technical Reports Server (NTRS)
Japp, John; Davis, Elizabeth; Maxwell, Theresa G. (Technical Monitor)
2002-01-01
Planning and scheduling systems organize "tasks" into a timeline or schedule. The tasks are defined within the scheduling system in logical containers called models. The dictionary might define a model of this type as "a system of things and relations satisfying a set of rules that, when applied to the things and relations, produce certainty about the tasks that are being modeled." One challenging domain for a planning and scheduling system is the operation of on-board experiment activities for the Space Station. The equipment used in these experiments is some of the most complex hardware ever developed by mankind, the information sought by these experiments is at the cutting edge of scientific endeavor, and the procedures for executing the experiments are intricate and exacting. Scheduling is made more difficult by a scarcity of space station resources. The models to be fed into the scheduler must describe both the complexity of the experiments and procedures (to ensure a valid schedule) and the flexibilities of the procedures and the equipment (to effectively utilize available resources). Clearly, scheduling space station experiment operations calls for a "maximally expressive" modeling schema. Modeling even the simplest of activities cannot be automated; no sensor can be attached to a piece of equipment that can discern how to use that piece of equipment; no camera can quantify how to operate a piece of equipment. Modeling is a human enterprise-both an art and a science. The modeling schema should allow the models to flow from the keyboard of the user as easily as works of literature flowed from the pen of Shakespeare. The Ground Systems Department at the Marshall Space Flight Center has embarked on an effort to develop a new scheduling engine that is highlighted by a maximally expressive modeling schema. This schema, presented in this paper, is a synergy of technological advances and domain-specific innovations.
Slim Battery Modelling Features
NASA Astrophysics Data System (ADS)
Borthomieu, Y.; Prevot, D.
2011-10-01
Saft has developed a life prediction model for VES and MPS cells and batteries. The Saft Li-ion Model (SLIM) is a macroscopic electrochemical model based on energy (global at cell level). The main purpose is to predict the battery performances during the life for GEO, MEO and LEO missions. This model is based on electrochemical characteristics such as Energy, Capacity, EMF, Internal resistance, end of charge voltage. It uses fading and calendar law effects on energy and internal impedance vs. time, temperature, End of Charge voltage. Based on the mission profile, satellite power system characteristics, the model proposes the various battery configurations. For each configuration, the model gives the battery performances using mission figures and profiles: power, duration, DOD, end of charge voltages, temperatures during eclipses and solstices, thermal dissipations and cell failures. For the GEO/MEO missions, eclipse and solstice periods can include specific profile such as plasmic propulsion fires and specific balancing operations. For LEO missions, the model is able to simulate high power peaks to predict radar pulses. Saft's main customers have been using the SLIM model available in house for two years. The purpose is to have the satellite builder power engineers able to perform by themselves in the battery pre-dimensioning activities their own battery simulations. The simulations can be shared with Saft engineers to refine the power system designs. This model has been correlated with existing life and calendar tests performed on all the VES and MPS cells. In comparing with more than 10 year lasting life tests, the accuracy of the model from a voltage point of view is less than 10 mV at end Of Life. In addition, thethe comparison with in-orbit data has been also done. b This paper will present the main features of the SLIM software and outputs comparison with real life tests. b0
Saturn Radiation (SATRAD) Model
NASA Technical Reports Server (NTRS)
Garrett, H. B.; Ratliff, J. M.; Evans, R. W.
2005-01-01
The Saturnian radiation belts have not received as much attention as the Jovian radiation belts because they are not nearly as intense-the famous Saturnian particle rings tend to deplete the belts near where their peak would occur. As a result, there has not been a systematic development of engineering models of the Saturnian radiation environment for mission design. A primary exception is that of Divine (1990). That study used published data from several charged particle experiments aboard the Pioneer 1 1, Voyager 1, and Voyager 2 spacecraft during their flybys at Saturn to generate numerical models for the electron and proton radiation belts between 2.3 and 13 Saturn radii. The Divine Saturn radiation model described the electron distributions at energies between 0.04 and 10 MeV and the proton distributions at energies between 0.14 and 80 MeV. The model was intended to predict particle intensity, flux, and fluence for the Cassini orbiter. Divine carried out hand calculations using the model but never formally developed a computer program that could be used for general mission analyses. This report seeks to fill that void by formally developing a FORTRAN version of the model that can be used as a computer design tool for missions to Saturn that require estimates of the radiation environment around the planet. The results of that effort and the program listings are presented here along with comparisons with the original estimates carried out by Divine. In addition, Pioneer and Voyager data were scanned in from the original references and compared with the FORTRAN model s predictions. The results were statistically analyzed in a manner consistent with Divine s approach to provide estimates of the ability of the model to reproduce the original data. Results of a formal review of the model by a panel of experts are also presented. Their recommendations for further tests, analyses, and extensions to the model are discussed.
Symbolic modeling of epistasis.
Moore, Jason H; Barney, Nate; Tsai, Chia-Ti; Chiang, Fu-Tien; Gui, Jiang; White, Bill C
2007-01-01
The workhorse of modern genetic analysis is the parametric linear model. The advantages of the linear modeling framework are many and include a mathematical understanding of the model fitting process and ease of interpretation. However, an important limitation is that linear models make assumptions about the nature of the data being modeled. This assumption may not be realistic for complex biological systems such as disease susceptibility where nonlinearities in the genotype to phenotype mapping relationship that result from epistasis, plastic reaction norms, locus heterogeneity, and phenocopy, for example, are the norm rather than the exception. We have previously developed a flexible modeling approach called symbolic discriminant analysis (SDA) that makes no assumptions about the patterns in the data. Rather, SDA lets the data dictate the size, shape, and complexity of a symbolic discriminant function that could include any set of mathematical functions from a list of candidates supplied by the user. Here, we outline a new five step process for symbolic model discovery that uses genetic programming (GP) for coarse-grained stochastic searching, experimental design for parameter optimization, graphical modeling for generating expert knowledge, and estimation of distribution algorithms for fine-grained stochastic searching. Finally, we introduce function mapping as a new method for interpreting symbolic discriminant functions. We show that function mapping when combined with measures of interaction information facilitates statistical interpretation by providing a graphical approach to decomposing complex models to highlight synergistic, redundant, and independent effects of polymorphisms and their composite functions. We illustrate this five step SDA modeling process with a real case-control dataset.
Selected Logistics Models and Techniques.
1984-09-01
Programmable Calculator LCC...Program 27 TI-59 Programmable Calculator LCC Model 30 Unmanned Spacecraft Cost Model 31 iv I: TABLE OF CONTENTS (CONT’D) (Subject Index) LOGISTICS...34"" - % - "° > - " ° .° - " .’ > -% > ]*° - LOGISTICS ANALYSIS MODEL/TECHNIQUE DATA MODEL/TECHNIQUE NAME: TI-59 Programmable Calculator LCC Model TYPE MODEL: Cost Estimating DEVELOPED BY:
Aydoğdu, A; Frasca, P; D'Apice, C; Manzo, R; Thornton, J M; Gachomo, B; Wilson, T; Cheung, B; Tariq, U; Saidel, W; Piccoli, B
2017-02-21
In this paper we introduce a mathematical model to study the group dynamics of birds resting on wires. The model is agent-based and postulates attraction-repulsion forces between the interacting birds: the interactions are "topological", in the sense that they involve a given number of neighbors irrespective of their distance. The model is first mathematically analyzed and then simulated to study its main properties: we observe that the model predicts birds to be more widely spaced near the borders of each group. We compare the results from the model with experimental data, derived from the analysis of pictures of pigeons and starlings taken in New Jersey: two different image elaboration protocols allow us to establish a good agreement with the model and to quantify its main parameters. We also discuss the potential handedness of the birds, by analyzing the group organization features and the group dynamics at the arrival of new birds. Finally, we propose a more refined mathematical model that describes landing and departing birds by suitable stochastic processes.
NASA Astrophysics Data System (ADS)
Jensen, Kristoffer
2002-11-01
A timbre model is proposed for use in multiple applications. This model, which encompasses all voiced isolated musical instruments, has an intuitive parameter set, fixed size, and separates the sounds in dimensions akin to the timbre dimensions as proposed in timbre research. The analysis of the model parameters is fully documented, and it proposes, in particular, a method for the estimation of the difficult decay/release split-point. The main parameters of the model are the spectral envelope, the attack/release durations and relative amplitudes, and the inharmonicity and the shimmer and jitter (which provide both for the slow random variations of the frequencies and amplitudes, and also for additive noises). Some of the applications include synthesis, where a real-time application is being developed with an intuitive gui, classification, and search of sounds based on the content of the sounds, and a further understanding of acoustic musical instrument behavior. In order to present the background of the model, this presentation will start with sinusoidal A/S, some timbre perception research, then present the timbre model, show the validity for individual music instrument sounds, and finally introduce some expression additions to the model.
Modelling urban growth patterns
NASA Astrophysics Data System (ADS)
Makse, Hernán A.; Havlin, Shlomo; Stanley, H. Eugene
1995-10-01
CITIES grow in a way that might be expected to resemble the growth of two-dimensional aggregates of particles, and this has led to recent attempts1á¤-3 to model urban growth using ideas from the statistical physics of clusters. In particular, the model of diffusion-limited aggregation4,5 (DLA) has been invoked to rationalize the apparently fractal nature of urban morphologies1. The DLA model predicts that there should exist only one large fractal cluster, which is almost perfectly screened from incoming á¤~development unitsá¤™ (representing, for example, people, capital or resources), so that almost all of the cluster growth takes place at the tips of the clusterá¤™s branches. Here we show that an alternative model, in which development units are correlated rather than being added to the cluster at random, is better able to reproduce the observed morphology of cities and the area distribution of sub-clusters (á¤~towns') in an urban system, and can also describe urban growth dynamics. Our physical model, which corresponds to the correlated percolation model6á¤-8 in the presence of a density gradient9, is motivated by the fact that in urban areas development attracts further development. The model offers the possibility of predicting the global properties (such as scaling behaviour) of urban morphologies.
Multiscale Cloud System Modeling
NASA Technical Reports Server (NTRS)
Tao, Wei-Kuo; Moncrieff, Mitchell W.
2009-01-01
The central theme of this paper is to describe how cloud system resolving models (CRMs) of grid spacing approximately 1 km have been applied to various important problems in atmospheric science across a wide range of spatial and temporal scales and how these applications relate to other modeling approaches. A long-standing problem concerns the representation of organized precipitating convective cloud systems in weather and climate models. Since CRMs resolve the mesoscale to large scales of motion (i.e., 10 km to global) they explicitly address the cloud system problem. By explicitly representing organized convection, CRMs bypass restrictive assumptions associated with convective parameterization such as the scale gap between cumulus and large-scale motion. Dynamical models provide insight into the physical mechanisms involved with scale interaction and convective organization. Multiscale CRMs simulate convective cloud systems in computational domains up to global and have been applied in place of contemporary convective parameterizations in global models. Multiscale CRMs pose a new challenge for model validation, which is met in an integrated approach involving CRMs, operational prediction systems, observational measurements, and dynamical models in a new international project: the Year of Tropical Convection, which has an emphasis on organized tropical convection and its global effects.
Invertebrate models of alcoholism.
Scholz, Henrike; Mustard, Julie A
2013-01-01
For invertebrates to become useful models for understanding the genetic and physiological mechanisms of alcoholism related behaviors and the predisposition towards alcoholism, several general requirements must be fulfilled. The animal should encounter ethanol in its natural habitat, so that the central nervous system of the organism will have evolved mechanisms for responding to ethanol exposure. How the brain adapts to ethanol exposure depends on its access to ethanol, which can be regulated metabolically and/or by physical barriers. Therefore, a model organism should have metabolic enzymes for ethanol degradation similar to those found in humans. The neurons and supporting glial cells of the model organism that regulate behaviors affected by ethanol should share the molecular and physiological pathways found in humans, so that results can be compared. Finally, the use of invertebrate models should offer advantages over traditional model systems and should offer new insights into alcoholism-related behaviors. In this review we will summarize behavioral similarities and identified genes and mechanisms underlying ethanol-induced behaviors in invertebrates. This review mainly focuses on the use of the nematode Caenorhabditis elegans, the honey bee Apis mellifera and the fruit fly Drosophila melanogaster as model systems. We will discuss insights gained from those studies in conjunction with their vertebrate model counterparts and the implications for future research into alcoholism and alcohol-induced behaviors.
Johnson, Jason K.; Oyen, Diane Adele; Chertkov, Michael; Netrapalli, Praneeth
2016-12-01
Inference and learning of graphical models are both well-studied problems in statistics and machine learning that have found many applications in science and engineering. However, exact inference is intractable in general graphical models, which suggests the problem of seeking the best approximation to a collection of random variables within some tractable family of graphical models. In this paper, we focus on the class of planar Ising models, for which exact inference is tractable using techniques of statistical physics. Based on these techniques and recent methods for planarity testing and planar embedding, we propose a greedy algorithm for learning the best planar Ising model to approximate an arbitrary collection of binary random variables (possibly from sample data). Given the set of all pairwise correlations among variables, we select a planar graph and optimal planar Ising model defined on this graph to best approximate that set of correlations. Finally, we demonstrate our method in simulations and for two applications: modeling senate voting records and identifying geo-chemical depth trends from Mars rover data.
Johnson, Jason K.; Oyen, Diane Adele; Chertkov, Michael; ...
2016-12-01
Inference and learning of graphical models are both well-studied problems in statistics and machine learning that have found many applications in science and engineering. However, exact inference is intractable in general graphical models, which suggests the problem of seeking the best approximation to a collection of random variables within some tractable family of graphical models. In this paper, we focus on the class of planar Ising models, for which exact inference is tractable using techniques of statistical physics. Based on these techniques and recent methods for planarity testing and planar embedding, we propose a greedy algorithm for learning the bestmore » planar Ising model to approximate an arbitrary collection of binary random variables (possibly from sample data). Given the set of all pairwise correlations among variables, we select a planar graph and optimal planar Ising model defined on this graph to best approximate that set of correlations. Finally, we demonstrate our method in simulations and for two applications: modeling senate voting records and identifying geo-chemical depth trends from Mars rover data.« less
Model molecules mimicking asphaltenes.
Sjöblom, Johan; Simon, Sébastien; Xu, Zhenghe
2015-04-01
Asphalthenes are typically defined as the fraction of petroleum insoluble in n-alkanes (typically heptane, but also hexane or pentane) but soluble in toluene. This fraction causes problems of emulsion formation and deposition/precipitation during crude oil production, processing and transport. From the definition it follows that asphaltenes are not a homogeneous fraction but is composed of molecules polydisperse in molecular weight, structure and functionalities. Their complexity makes the understanding of their properties difficult. Proper model molecules with well-defined structures which can resemble the properties of real asphaltenes can help to improve this understanding. Over the last ten years different research groups have proposed different asphaltene model molecules and studied them to determine how well they can mimic the properties of asphaltenes and determine the mechanisms behind the properties of asphaltenes. This article reviews the properties of the different classes of model compounds proposed and present their properties by comparison with fractionated asphaltenes. After presenting the interest of developing model asphaltenes, the composition and properties of asphaltenes are presented, followed by the presentation of approaches and accomplishments of different schools working on asphaltene model compounds. The presentation of bulk and interfacial properties of perylene-based model asphaltene compounds developed by Sjöblom et al. is the subject of the next part. Finally the emulsion-stabilization properties of fractionated asphaltenes and model asphaltene compounds is presented and discussed.