78 FR 67385 - 30-Day Notice of Proposed Information Collection: FHA PowerSaver Pilot Program (Title I Property...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-12

... Information Collection: FHA PowerSaver Pilot Program (Title I Property Improvement and Title II--203(k... days was published on August 9, 2013. A. Overview of Information Collection Title of Information Collection: FHA PowerSaver Pilot Program (Title I Property Improvement and Title II--203(k) Rehabilitation...

78 FR 48709 - 60-Day Notice of Proposed Information Collection: FHA PowerSaver Pilot Program-Title I Property...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-09

... Information Collection: FHA PowerSaver Pilot Program--Title I Property Improvement and Title II--203(k... collection described in Section A. A. Overview of Information Collection Title of Information Collection: FHA PowerSaver Pilot Program Title I Property Improvement and Title II--203(k) Rehabilitation Mortgage...

24 CFR 9.152 - Program accessibility: alterations of Property Disposition Program multifamily housing facilities.

Code of Federal Regulations, 2012 CFR

2012-04-01

... of Property Disposition Program multifamily housing facilities. 9.152 Section 9.152 Housing and Urban... URBAN DEVELOPMENT § 9.152 Program accessibility: alterations of Property Disposition Program multifamily housing facilities. (a) Substantial alteration. If the agency undertakes alterations to a PDP multifamily...

24 CFR 9.152 - Program accessibility: alterations of Property Disposition Program multifamily housing facilities.

Code of Federal Regulations, 2014 CFR

2014-04-01

... of Property Disposition Program multifamily housing facilities. 9.152 Section 9.152 Housing and Urban... URBAN DEVELOPMENT § 9.152 Program accessibility: alterations of Property Disposition Program multifamily housing facilities. (a) Substantial alteration. If the agency undertakes alterations to a PDP multifamily...

76 FR 9043 - Notice of Proposed Information Collection: Comment Request; Application for HUD/FHA Insured...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-16

... Information Collection: Comment Request; Application for HUD/FHA Insured Mortgage ``HOPE for Homeowners... information: Title of Proposal: HUD/FHA Insured Mortgage ``HOPE'' for Homeowners. OMB Control Number, if... homes to foreclosure through the HOPE for Homeowners Program, and to those who owe more than the value...

North Carolina FHA/HERO Proficiency Event Handbook 1988-1990. "Students Taking Action for Recognition."

ERIC Educational Resources Information Center

North Carolina State Dept. of Public Instruction, Raleigh. Div. of Vocational Education.

This handbook is designed to provide opportunities for members of the North Carolina Association of Future Homemakers of America (FHA) to demonstrate their proficiency with the competencies they have developed through participation in FHA and the home economics education program. The 25 events are designed to help develop lifetime skills in…

24 CFR 200.610 - Policy.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Policy. 200.610 Section 200.610... GENERAL INTRODUCTION TO FHA PROGRAMS Affirmative Fair Housing Marketing Regulations § 200.610 Policy. It is the policy of the Department to administer its FHA housing programs affirmatively, as to achieve a...

24 CFR 9.152 - Program accessibility: alterations of Property Disposition Program multifamily housing facilities.

Code of Federal Regulations, 2010 CFR

2010-04-01

... of Property Disposition Program multifamily housing facilities. 9.152 Section 9.152 Housing and Urban... URBAN DEVELOPMENT § 9.152 Program accessibility: alterations of Property Disposition Program multifamily...) in such a project shall be accessible for persons with hearing or vision impairments. If state or...

24 CFR 9.152 - Program accessibility: alterations of Property Disposition Program multifamily housing facilities.

Code of Federal Regulations, 2011 CFR

2011-04-01

... of Property Disposition Program multifamily housing facilities. 9.152 Section 9.152 Housing and Urban... URBAN DEVELOPMENT § 9.152 Program accessibility: alterations of Property Disposition Program multifamily...) in such a project shall be accessible for persons with hearing or vision impairments. If state or...

California Multifamily Affordable Solar Housing Program: benefitting both owners and tenants

EPA Pesticide Factsheets

California’s Multifamily Affordable Solar Housing (MASH) program has brought solar energy to thousands of multifamily building owners and tenants across the state. Discover lessons learned through this case study.

76 FR 52677 - Notice of Proposed Information Collection: Comment Request; Application for Energy Innovation...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-23

... Information Collection: Comment Request; Application for Energy Innovation Fund--Multifamily Pilot Program... Deputy Assistant Secretary for Affordable Housing Preservation, Multifamily Housing Division, Department... Fund-- Multifamily Pilot Program. OMB Control Number, if applicable: 2502-0599. Description of the need...

76 FR 67470 - Notice of Submission of Proposed Information Collection to OMB; Energy Innovation Fund...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-01

... Proposed Information Collection to OMB; Energy Innovation Fund--Multifamily Energy Pilot Program AGENCY... proposals for increasing the energy efficiency of Multifamily Housing. DATES: Comments Due Date: December 1... following information: Title of Proposal: Energy Innovation Fund--Multifamily Energy Pilot Program. OMB...

76 FR 66317 - Notice of Submission of Proposed Information Collection to OMB; Management Reviews of Multifamily...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-26

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5480-N-107] Notice of Submission of Proposed Information Collection to OMB; Management Reviews of Multifamily Housing Programs AGENCY: Office... Lists the Following Information Title Of Proposal: Management Reviews of Multifamily Housing Programs...

78 FR 25755 - Announcement of Funding Awards; Energy Innovation Fund-Multifamily Pilot Program Fiscal Year 2010

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-02

... Awards; Energy Innovation Fund-- Multifamily Pilot Program Fiscal Year 2010 AGENCY: Office of the... funding under the Notice of Funding Availability (NOFA) for the Energy Innovation Fund--Multifamily Pilot.... FOR FURTHER INFORMATION CONTACT: Linda W. Field, Director of Portfolio Management, Office of...

77 FR 65011 - Notice of Proposed Information Collection: Comment Request; FHA-Insured Mortgage Loan Servicing...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-24

... Information Collection: Comment Request; FHA- Insured Mortgage Loan Servicing Involving the Loss Mitigation... other forms of information technology, e.g., permitting electronic submission of responses. This Notice... the Loss Mitigation Programs. OMB Control Number, if applicable: 2502-0589. Description of the need...

Montana Proficiency Events Handbook. FHA HERO: Future Homemakers of America toward New Horizons.

ERIC Educational Resources Information Center

McGregor, Linda, Ed.; Quickenden, Sandy, Ed.

This handbook contains directions for FHA/HERO (Future Homemakers of America/Home Economics Related Occupations) participation activities in Montana. Participation activities are local, state, and national level competitions involving students in vocational home economics programs. The handbook provides a general overview of participation…

Multifamily Therapy in Substance Abuse Treatment with Women.

ERIC Educational Resources Information Center

Boylin, William M.; Doucette, Joseph; Jean, Mary F.

1997-01-01

Describes the establishment of a multifamily therapy program within an adult substance abuse treatment facility. Reports on a study in which the effectiveness of multifamily therapy was assessed with regard to women in treatment. Findings indicate that multifamily therapy is an extremely positive intervention for female substance abuse clients.…

78 FR 40312 - 30-Day Notice of Proposed Information Collection: FHA TOTAL (Technology Open to Approved Lenders...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-03

... the FHA Transformation Program, Single Family Housing is moving the TOTAL Scorecard to the Mortgage... used throughout the industry and are therefore listed as industry standard business practice. The...-0059 will be affected in the two initial transformation phases and Informed Consumer Choice Notice and...

78 FR 57058 - Federal Housing Administration (FHA) Approval of Lending Institutions and Mortgagees: Streamlined...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-17

... federal banking agencies and reduce the cost of participating in FHA programs by releasing small... retained earnings, a statement of cash flows, an analysis of the lender's or mortgagee's net worth adjusted...: Streamlined Reporting Requirements for Small Supervised Lenders and Mortgagees AGENCY: Office of the Assistant...

75 FR 78730 - Federal Housing Administration (FHA): Notice of FHA PowerSaver Home Energy Retrofit Loan Pilot...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-16

... Efficient Mortgage Innovation pilot program targeted to the single family housing market, and the Retrofit... effort. The November 10, 2010, notice solicited public comment and invited lenders interested in... public comments and expressions of interest from lenders is December 27, 2010. This notice extends the...

77 FR 23272 - Proposed Information Collection; Comment Request: FHA Insured Title I Property Improvement and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-18

... Collection; Comment Request: FHA Insured Title I Property Improvement and Manufactured Home Loan Programs.... This Notice also lists the following information: Title of Proposal: Title I Property Improvement and... information and proposed use: Title I loans are made by private-sector lenders and insured by HUD against loss...

76 FR 74804 - Federal Housing Administration (FHA) First Look Sales Method Under the Neighborhood Stabilization...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-01

... participate in the First Look Sales Method. This notice announces the availability of a universal NAID to aid... universal NAID to aid eligible NSP purchasers in the purchase of properties under First Look Sales Method... Administration (FHA) First Look Sales Method Under the Neighborhood Stabilization Programs (NSP) Technical...

Financing Home Energy and Renewable Energy Improvements with FHA PowerSaver Loans (Fact Sheet)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

2014-07-01

This fact sheet is a revision to the PowerSaver Loan Benefits fact sheet from April 2014. It describes how the U.S. Department of Housing and Urban Development (HUD) PowerSaver Loan Program offers borrowers low-cost FHA-insured loans to make energy-saving improvements to their homes.

National Energy Audit Tool for Multifamily Buildings Development Plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

Malhotra, Mini; MacDonald, Michael; Accawi, Gina K

The U.S. Department of Energy's (DOE's) Weatherization Assistance Program (WAP) enables low-income families to reduce their energy costs by providing funds to make their homes more energy efficient. In addition, the program funds Weatherization Training and Technical Assistance (T and TA) activities to support a range of program operations. These activities include measuring and documenting performance, monitoring programs, promoting advanced techniques and collaborations to further improve program effectiveness, and training, including developing tools and information resources. The T and TA plan outlines the tasks, activities, and milestones to support the weatherization network with the program implementation ramp up efforts. Weatherizationmore » of multifamily buildings has been recognized as an effective way to ramp up weatherization efforts. To support this effort, the 2009 National Weatherization T and TA plan includes the task of expanding the functionality of the Weatherization Assistant, a DOE-sponsored family of energy audit computer programs, to perform audits for large and small multifamily buildings This report describes the planning effort for a new multifamily energy audit tool for DOE's WAP. The functionality of the Weatherization Assistant is being expanded to also perform energy audits of small multifamily and large multifamily buildings. The process covers an assessment of needs that includes input from national experts during two national Web conferences. The assessment of needs is then translated into capability and performance descriptions for the proposed new multifamily energy audit, with some description of what might or should be provided in the new tool. The assessment of needs is combined with our best judgment to lay out a strategy for development of the multifamily tool that proceeds in stages, with features of an initial tool (version 1) and a more capable version 2 handled with currently available resources. Additional development in the future is expected to be needed if more capabilities are to be added. A rough schedule for development of the version 1 tool is presented. The components and capabilities described in this plan will serve as the starting point for development of the proposed new multifamily energy audit tool for WAP.« less

National Weatherization Assistance Program Impact Evaluation: Energy Impacts for Large Multifamily Buildings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blasnik, Michael; Dalhoff, Greg; Carroll, David

This report estimates energy savings, energy cost savings, and cost effectiveness attributable to weatherizing large multifamily buildings under the auspices of the Department of Energy's Weatherization Assistance Program during Program Year 2008.

National Weatherization Assistance Program Impact Evaluation: Energy Impacts for Small Multifamily Buildings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blasnik, Michael; Dalhoff, Greg; Carroll, David

2014-09-01

This report estimates energy savings, energy cost savings, and cost effectiveness attributable to weatherizing small multifamily buildings under the auspices of the Department of Energy's Weatherization Assistance Program during Program Year 2008.

Field Testing of Compartmentalization Methods for Multifamily Construction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ueno, K.; Lstiburek, J. W.

2015-03-01

The 2012 International Energy Conservation Code (IECC) has an airtightness requirement of 3 air changes per hour at 50 Pascals test pressure (3 ACH50) for single-family and multifamily construction (in climate zones 3–8). The Leadership in Energy & Environmental Design certification program and ASHRAE Standard 189 have comparable compartmentalization requirements. ASHRAE Standard 62.2 will soon be responsible for all multifamily ventilation requirements (low rise and high rise); it has an exceptionally stringent compartmentalization requirement. These code and program requirements are driving the need for easier and more effective methods of compartmentalization in multifamily buildings.

Training Undergraduates as Co-Leaders of Multifamily Counseling Groups

ERIC Educational Resources Information Center

Kuppersmith, Judith; And Others

1977-01-01

A field-training pilot program at Richmond College in 1973 is described. It used undergraduates as leaders for multifamily counseling groups. Discussed are program planning, student selection, training procedures, supervision methods, and project benefits. (ND)

75 FR 6684 - Notice of Proposed Information Collection: Comment Request; Multifamily Housing Service...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-10

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5380-N-02] Notice of Proposed Information Collection: Comment Request; Multifamily Housing Service Coordinator Grant AGENCY: Office of the... Information: Title of Proposal: Multifamily Housing Service Coordinator Program. OMB Control Number, if...

Fire hazard analysis for Plutonium Finishing Plant complex

DOE Office of Scientific and Technical Information (OSTI.GOV)

MCKINNIS, D.L.

1999-02-23

A fire hazards analysis (FHA) was performed for the Plutonium Finishing Plant (PFP) Complex at the Department of Energy (DOE) Hanford site. The scope of the FHA focuses on the nuclear facilities/structures in the Complex. The analysis was conducted in accordance with RLID 5480.7, [DOE Directive RLID 5480.7, 1/17/94] and DOE Order 5480.7A, ''Fire Protection'' [DOE Order 5480.7A, 2/17/93] and addresses each of the sixteen principle elements outlined in paragraph 9.a(3) of the Order. The elements are addressed in terms of the fire protection objectives stated in paragraph 4 of DOE 5480.7A. In addition, the FHA also complies with WHC-CM-4-41,more » Fire Protection Program Manual, Section 3.4 [1994] and WHC-SD-GN-FHA-30001, Rev. 0 [WHC, 1994]. Objectives of the FHA are to determine: (1) the fire hazards that expose the PFP facilities, or that are inherent in the building operations, (2) the adequacy of the fire safety features currently located in the PFP Complex, and (3) the degree of compliance of the facility with specific fire safety provisions in DOE orders, related engineering codes, and standards.« less

75 FR 45147 - Notice of Submission of Proposed Information Collection to OMB; Multifamily Project Construction...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-02

... Proposed Information Collection to OMB; Multifamily Project Construction Contract, Building Loan Agreement, & Construction Change; HUD Programs AGENCY: Office of the Chief Information Officer, HUD. ACTION: Notice. SUMMARY.../borrowers, and mortgagees/lenders for construction of multifamily projects and to obtain approval of changes...

77 FR 3998 - U.S. Department of Agriculture Multi-Family Housing Program 2012 Industry Forums-Open...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-26

... DEPARTMENT OF AGRICULTURE Rural Housing Service U.S. Department of Agriculture Multi-Family Housing Program 2012 Industry Forums--Open Teleconference and/or Web Conference Meetings AGENCY: Rural Housing Service, USDA. [[Page 3999

24 CFR 401.453 - Reserves.

Code of Federal Regulations, 2014 CFR

2014-04-01

... HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM (MARK-TO-MARKET...

24 CFR 401.453 - Reserves.

Code of Federal Regulations, 2011 CFR

2011-04-01

... HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM (MARK-TO-MARKET...

24 CFR 401.453 - Reserves.

Code of Federal Regulations, 2012 CFR

2012-04-01

... HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM (MARK-TO-MARKET...

24 CFR 401.453 - Reserves.

Code of Federal Regulations, 2010 CFR

2010-04-01

... HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM (MARK-TO-MARKET...

24 CFR 401.301 - Partnership arrangements.

Code of Federal Regulations, 2014 CFR

2014-04-01

... (Continued) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM...

24 CFR 401.472 - Rehabilitation funding.

Code of Federal Regulations, 2012 CFR

2012-04-01

... (Continued) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM...

24 CFR 401.472 - Rehabilitation funding.

Code of Federal Regulations, 2014 CFR

2014-04-01

... (Continued) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM...

24 CFR 401.472 - Rehabilitation funding.

Code of Federal Regulations, 2011 CFR

2011-04-01

... (Continued) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM...

24 CFR 401.301 - Partnership arrangements.

Code of Federal Regulations, 2011 CFR

2011-04-01

... (Continued) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM...

24 CFR 401.301 - Partnership arrangements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... (Continued) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM...

24 CFR 401.301 - Partnership arrangements.

Code of Federal Regulations, 2012 CFR

2012-04-01

... (Continued) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM...

24 CFR 401.310 - Conflicts of interest.

Code of Federal Regulations, 2014 CFR

2014-04-01

... (Continued) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM...

24 CFR 401.503 - Access to information.

Code of Federal Regulations, 2014 CFR

2014-04-01

... (Continued) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM...

24 CFR 401.474 - Project accounts.

Code of Federal Regulations, 2010 CFR

2010-04-01

...) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM (MARK-TO...

24 CFR 401.310 - Conflicts of interest.

Code of Federal Regulations, 2012 CFR

2012-04-01

... (Continued) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM...

24 CFR 401.503 - Access to information.

Code of Federal Regulations, 2011 CFR

2011-04-01

... (Continued) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM...

24 CFR 401.310 - Conflicts of interest.

Code of Federal Regulations, 2011 CFR

2011-04-01

... (Continued) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM...

24 CFR 401.311 - Standards of conduct.

Code of Federal Regulations, 2010 CFR

2010-04-01

... (Continued) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM...

24 CFR 401.311 - Standards of conduct.

Code of Federal Regulations, 2011 CFR

2011-04-01

... (Continued) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM...

24 CFR 401.311 - Standards of conduct.

Code of Federal Regulations, 2012 CFR

2012-04-01

... (Continued) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM...

24 CFR 401.311 - Standards of conduct.

Code of Federal Regulations, 2014 CFR

2014-04-01

... (Continued) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM...

24 CFR 401.503 - Access to information.

Code of Federal Regulations, 2010 CFR

2010-04-01

... (Continued) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM...

Interim Final Report for the Strengthening Retrofit Markets for Comprehensive Savings in Multifamily Buildings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meinking, Rick; Adamson, Joy M

2013-12-20

Energy efficiency is vitally important in Maine. Nearly 70% of Maine households rely on fuel oil as their primary energy source for home heating, a higher share than in any other state. Coupled with the state's long, cold winters, Maine's dependence on oil renders homeowners particularly vulnerable to fluctuating fuel costs. With $4.5 million in seed funding from the Energy Department's Better Buildings Neighborhood Program, the Governor's Energy Office (GEO), through Efficiency Maine Trust (the Trust), is spurring Maine landlords to lower their monthly energy bills and improve comfort for their tenants during the state's cold winter months and increasinglymore » warmer summers. Maine's aging multifamily housing stock can be expensive to heat and costly to maintain. It is not unusual to find buildings with little or no insulation, drafty windows, and significant air leaks, making them ideal candidates for energy efficiency upgrades. Maine modeled its Multifamily Efficiency Program (MEP) after the state's highly successful Home Energy Savings Program (HESP) for single-family homes. HESP provided cash incentives and financing opportunities to owners of one-to four-unit structures, which resulted in thousands of energy assessments and whole-house energy upgrades in 225 communities. Maine's new MEP multifamily energy efficiency upgrade and weatherization initiative focuses on small to medium-sized (i.e., five to 20 units) apartment buildings. The program's energy efficiency upgrades will provide at least 20% energy savings for each upgraded multifamily unit. The Trust’s MEP relies on a network of approved program partners who help move projects through the pipeline from assessment to upgrade. MEP has two components: benchmarking and development of an Energy Reduction Plan (ERP). Using the ENERGY STAR® Portfolio Manager benchmarking tool, MEP provides an assessment of current energy usage in the building, establishes a baseline for future energy efficiency improvements, and enables tracking and monitoring of future energy usage at the building— all at no cost to the building owner. The ERP is developed by a program partner using either the Trust’s approved modeling or prescriptive tools; it provides detailed information about the current energyrelated conditions in the building and recommends energy efficiency, health, and safety improvements. The Trust's delivery contractor provides quality assurance and controls throughout the process. Through this effort, MEP's goal is to establish a self-sustaining, market-driven program, demonstrating the value of energy efficiency to other building owners. The increasing value of properties across the state will help incentivize these owners to continue upgrades after the grant period has ended. Targeting urban areas in Maine with dense clusters of multifamily units—such as Portland, Lewiston- Auburn, Bangor, and Augusta—MEP engaged a variety of stakeholder groups early on to design its multifamily program. Through direct emails and its website, program officials invited lending institutions, building professionals, engineering firms, equipment distributors, and local property owners associations to attend open meetings around the state to learn about the goals of the multifamily program and to help define its parameters. These meetings helped program administrators understand the diversity of the customer base: some owners are individuals with a single building, while other owners are groups of people or management companies with an entire portfolio of multifamily buildings. The diversity of the customer base notwithstanding, owners see MEP as an opportunity to make gains in their respective properties. Consistently high turnouts at stakeholder meetings fueled greater customer interest as awareness of the program spread through word of mouth. The program also gained traction by utilizing the program partner networks and building on the legacy of the Trust’s successful HESP for single-family residences. MEP offers significant incentives for building owners to participate in the upgrade program. Wholebuilding benchmarking services are available to most multifamily housing buildings free of charge. The service provides the building owner with an assessment of the building's current energy efficiency as compared to other multifamily buildings on a national scale, establishes a baseline to measure future improvements, and enables owners to track monthly energy consumption using the ENERGY STAR Portfolio Manager. Once the benchmarking process is complete, the program links building owners with approved program partners (e.g., energy professionals, home performance contractors) to identify and implement specific energy-saving opportunities in the building. Program partners can also provide project quotes with estimated financing incentives and payback period calculations that enable building owners to make informed decisions. What's more, the Trust provides two financial incentives for successful completion of program milestones. The first is a per-unit incentive for completion of an approved ERP (i.e., $100 per unit if a prescriptive path is followed, and $200 per unit for a modeled ERP). Upon final inspection of the installed project scope of work, an incentive of $1,400 per unit or 50% of installed cost—whichever is less—is paid. The Trust originally established a $1 million loan-loss reserve fund (LLRF) to further enhance financing opportunities for qualified multifamily building owners. This funding mechanism was designed to connect building owners with lenders that retain the mortgages for their properties and encourages the lenders to offer financing for energy efficiency improvements. However, there has been no interest in the LLRF and therefore the LLRF has been reduced. Ultimately, MEP plans to build an online tool for building owners to assess opportunities to make upgrades in their multifamily units. The tool will include a performance rating system to provide a way for building owners to more easily understand energy use in their building, and how it could be improved with energy efficiency upgrades. Prospective tenants will also be able to use the rating system to make informed decisions about where to rent. Furthermore, the rating can be incorporated into real estate listings as a way for prospective home buyers and the real estate financial community to evaluate a home's operating costs. The Trust’s MEP has identified the state's most experienced energy professionals, vendors, suppliers, and contractors that install energy efficiency equipment in the multifamily sector to be qualified program partners. To be eligible for partnership, energy assessment professionals and contractors are required to have demonstrated experience in the multifamily sector and hold associated professional certifications, such as Building Operator Certification (BOC), Certified Energy Manager (CEM), Professional Engineer (PE), or Building Performance Institute (BPI) Multifamily Building Analyst. Widespread program interest has enabled the Trust to redirect funds that might otherwise be needed for program promotion to building capacity through contractor training. In addition to boosting professional training and certification opportunities, MEP teaches its partners how to market the multifamily program to prospective multifamily homeowners.« less

24 CFR 401.407 - Closing conducted by PAE.

Code of Federal Regulations, 2014 CFR

2014-04-01

... (Continued) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM...

24 CFR 401.407 - Closing conducted by PAE.

Code of Federal Regulations, 2012 CFR

2012-04-01

... (Continued) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM...

24 CFR 401.407 - Closing conducted by PAE.

Code of Federal Regulations, 2011 CFR

2011-04-01

... (Continued) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM...

24 CFR 401.201 - How does HUD select PAEs?

Code of Federal Regulations, 2014 CFR

2014-04-01

... (Continued) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM...

24 CFR 401.300 - What is a PRA?

Code of Federal Regulations, 2011 CFR

2011-04-01

...) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM (MARK-TO...

24 CFR 401.201 - How does HUD select PAEs?

Code of Federal Regulations, 2012 CFR

2012-04-01

... (Continued) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM...

24 CFR 401.300 - What is a PRA?

Code of Federal Regulations, 2012 CFR

2012-04-01

...) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM (MARK-TO...

24 CFR 401.201 - How does HUD select PAEs?

Code of Federal Regulations, 2011 CFR

2011-04-01

... (Continued) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM...

24 CFR 401.201 - How does HUD select PAEs?

Code of Federal Regulations, 2010 CFR

2010-04-01

... (Continued) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM...

24 CFR 401.200 - Who may be a PAE?

Code of Federal Regulations, 2014 CFR

2014-04-01

...) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM (MARK-TO...

24 CFR 401.200 - Who may be a PAE?

Code of Federal Regulations, 2011 CFR

2011-04-01

...) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM (MARK-TO...

24 CFR 401.200 - Who may be a PAE?

Code of Federal Regulations, 2010 CFR

2010-04-01

...) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM (MARK-TO...

24 CFR 401.200 - Who may be a PAE?

Code of Federal Regulations, 2012 CFR

2012-04-01

...) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM (MARK-TO...

76 FR 79704 - Annual Indexing of Basic Statutory Mortgage Limits for Multifamily Housing Programs

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-22

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5592-N-01] Annual Indexing of Basic Statutory Mortgage Limits for Multifamily Housing Programs AGENCY: Office of the Assistant Secretary for Housing--Federal Housing Commissioner, HUD. ACTION: Notice. SUMMARY: In accordance with Section 206A of...

76 FR 10387 - Annual Indexing of Basic Statutory Mortgage Limits for Multifamily Housing Programs

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-24

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5388-N-02] Annual Indexing of Basic Statutory Mortgage Limits for Multifamily Housing Programs AGENCY: Office of the Assistant Secretary for Housing--Federal Housing Commissioner, HUD. ACTION: Notice. SUMMARY: In accordance with Section 206A of...

75 FR 5800 - Annual Indexing of Basic Statutory Mortgage Limits for Multifamily Housing Programs

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-04

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5388-N-01] Annual Indexing of Basic Statutory Mortgage Limits for Multifamily Housing Programs AGENCY: Office of the Assistant Secretary for Housing--Federal Housing Commissioner, HUD. ACTION: Notice. SUMMARY: In accordance with Section 206A of...

HUD PowerSaver Pilot Loan Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zimring, Mark; Hoffman, Ian

2010-12-10

The U.S. Department of Housing and Urban Development (HUD) recently announced the creation of a pilot loan program for home energy improvements. The PowerSaver loan program is a new, energy-focused variant of the Title I Property Improvement Loan Insurance Program (Title I Program) and is planned for introduction in early 2011. The PowerSaver pilot will provide lender insurance for secured and unsecured loans up to $25,000 to single family homeowners. These loans will specifically target residential energy efficiency and renewable energy improvements. HUD estimates the two-year pilot will fund approximately 24,000 loans worth up to $300 million; the program ismore » not capped. The Federal Housing Administration (FHA), HUD's mortgage insurance unit, will provide up to $25 million in grants as incentives to participating lenders. FHA is seeking lenders in communities with existing programs for promoting residential energy upgrades.« less

24 CFR 4001.01 - Purpose of program.

Code of Federal Regulations, 2010 CFR

2010-04-01

...) BOARD OF DIRECTORS OF THE HOPE FOR HOMEOWNERS PROGRAM HOPE FOR HOMEOWNERS PROGRAM HOPE for Homeowners Program-General Requirements § 4001.01 Purpose of program. The HOPE for Homeowners Program is a temporary... avoid foreclosure. The HOPE for Homeowners Program is administered by HUD through FHA. ...

Mini-Split Heat Pumps Multifamily Retrofit Feasibility Study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dentz, Jordan; Podorson, David; Varshney, Kapil

Mini-split heat pumps can provide space heating and cooling in many climates and are relatively affordable. These and other features make them potentially suitable for retrofitting into multifamily buildings in cold climates to replace electric resistance heating or other outmoded heating systems. This report investigates the suitability of mini-split heat pumps for multifamily retrofits. Various technical and regulatory barriers are discussed and modeling was performed to compare long-term costs of substituting mini-splits for a variety of other heating and cooling options. A number of utility programs have retrofit mini-splits in both single family and multifamily residences. Two such multifamily programsmore » are discussed in detail.« less

Mini-Split Heat Pumps Multifamily Retrofit Feasibility Study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dentz, J.; Podorson, D.; Varshney, K.

2014-05-01

Mini-split heat pumps can provide space heating and cooling in many climates and are relatively affordable. These and other features make them potentially suitable for retrofitting into multifamily buildings in cold climates to replace electric resistance heating or other outmoded heating systems. This report investigates the suitability of mini-split heat pumps for multifamily retrofits. Various technical and regulatory barriers are discussed and modeling was performed to compare long-term costs of substituting mini-splits for a variety of other heating and cooling options. A number of utility programs have retrofit mini-splits in both single family and multifamily residences. Two such multifamily programsmore » are discussed in detail.« less

Retrofits we`d rather forget

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hurrelbrinck, N.

1996-01-01

We all make mistakes, and the best of us make some of the biggest and best ones. An energy service company in New York installed light sensitive thermostats in a complex where the residents covered windows with heavy curtains to curtail air leakage. A crew in Chicago forgot to place a top plate in the top floor bathroom of a multifamily building; when they blew insulation into the roof, it filled the bathroom. A state official in the Midwest was inspecting the attic insulation in an FHA house when his foot slipped off the walk board and went through themore » ceiling drywall. And weatherization experts in Pittsburgh have discovered that a blower door can fill a house with decades` worth of accumulated soot. These mishaps could visit anyone. Much as those visited would rather bury them, we think they deserve an airing on the pages of Home Energy. In this issue, we present some cautionary tales from the elites of insulation.« less

75 FR 80790 - Multi-Family Housing Program 2011 Industry Forums-Open Teleconference and/or Web Conference Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-23

...--Open Teleconference and/or Web Conference Meetings AGENCY: Rural Housing Service, USDA. ACTION: Notice. SUMMARY: This Notice announces a series of teleconference and/or Web conference meetings regarding the USDA Multi-Family Housing Program. The teleconference and/or Web conference meetings will be scheduled...

78 FR 12032 - U.S. Department of Agriculture Multi-Family Housing Program 2013 Industry Forums-Open...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-21

... DEPARTMENT OF AGRICULTURE Rural Housing Service U.S. Department of Agriculture Multi-Family Housing Program 2013 Industry Forums--Open Teleconference and/or Web Conference Meetings AGENCY: Rural... at www.ascr.usda.gov , or write to: U.S Department of Agriculture, Office of the Assistance Secretary...

Evaluation of Passive Vents in New Construction Multifamily Buildings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sean Maxwell; Berger, David; Zuluaga, Marc

Exhaust ventilation and corresponding outdoor air strategies are being implemented in high performance, new construction, multifamily buildings to meet program or code requirements for improved indoor air quality, but a lack of clear design guidance is resulting in poor performance of these systems despite the best intentions of the programs or standards.

Building America Case Study: Field Testing of Compartmentalization Methods for Multifamily Construction (Fact Sheet)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

2015-01-01

The 2012 IECC has an airtightness requirement of 3 air changes per hour at 50 Pascals test pressure for both single family and multifamily construction in Climate Zones 3-8. Other programs (LEED, ASHRAE 189, ASHRAE 62.2) have similar or tighter compartmentalization requirements, thus driving the need for easier and more effective methods of compartmentalization in multifamily buildings.

Hyperandrogenism in female athletes with functional hypothalamic amenorrhea: a distinct phenotype.

PubMed

Javed, Asma; Kashyap, Rahul; Lteif, Aida N

2015-01-01

To compare the reproductive, metabolic, and skeletal profiles of young athletic women with functional hypothalamic amenorrhea (FHA) as well as clinical or biochemical hyperandrogenism (FHA-EX+HA) with body mass index matched women with FHA due to exercise (FHA-EX) or anorexia nervosa (FHA-AN) alone. Retrospective cohort study. Tertiary care teaching hospital. Adolescents and young women, 15-30 years of age, diagnosed with FHA along with concurrent signs of hyperandrogenism (n=22) and body mass index matched control groups consisting of 22 women in each group of FHA-EX and FHA-AN. 1) Reproductive hormone profile: luteinizing hormone (LH), follicle stimulating hormone (FSH), total testosterone, pelvic ultrasound features. 2) Metabolic function and skeletal health markers: fasting glucose, cholesterol, number of stress fractures and bone mineral density as assessed by spine dual-energy X-ray absorptiometry z scores. FHA-EX+HA group was older at diagnosis compared to the other groups with a median (interquartile range [IQR]) age of 22 (18.75-25.25) years versus (vs) 17.5 (15.75-19) for FHA-EX; (P<0.01) and 18 (16-22.25) years for FHA-AN (P=0.01). There were no differences among the groups based on number of hours of exercise per week, type of physical activity or duration of amenorrhea. Median (IQR) LH/FSH ratio was higher in FHA-EX+HA than both other groups, 1.44 (1.03-1.77) vs 0.50 (0.20-0.94) for FHA-EX and 0.67 (0.51-0.87) for FHA-AN (P<0.01 for both). Total testosterone concentrations were not different among the groups. Median (IQR) fasting serum glucose concentration was higher in FHA-EX+HA vs FHA-EX, 88.5 mg/dL (82.8-90 mg/dL) vs 83.5 mg/dL (78.8-86.3 mg/dL) (P=0.01) but not different from FHA-AN (P=0.31). Percentage of women with stress fractures was lower in FHA-EX+HA (4.5%) as compared to both FHA-EX (27.3%) and FHA-AN (50%); P=0.04 and 0.01 respectively. The LH/FSH ratio was weakly positively associated with serum glucose (adjusted r (2)=0.102; P=0.01) as well as with dual-energy X-ray absorptiometry spine score (adjusted r (2)=0.191; P=0.04) in the entire cohort. In a small cohort of female athletes with hyperandrogenism, a distinct reproductive hormone profile consisting of higher LH to FHS ratio may be associated with adverse metabolic health markers but improved skeletal health.

75 FR 20717 - Federal Housing Administration: Continuation of FHA Reform; Strengthening Risk Management Through...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-20

... Administration: Continuation of FHA Reform; Strengthening Risk Management Through Responsible FHA-Approved...) that are designed to strengthen FHA by improving its management of risk. This final rule increases the... designed to enhance FHA's risk management functions. The announcement preceded completion of an independent...

Evaluation of CNT Energy Savers Retrofit Packages Implemented in Multifamily Buildings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Farley, Jenne; Ruch, Russell

This evaluation explored the feasibility of designing prescriptive retrofit measure packages for typical Chicago region multifamily buildings in order to achieve 25%-30% source energy savings through the study of three case studies. There is an urgent need to scale up energy efficiency retrofitting of Chicago's multifamily buildings in order to address rising energy costs and a rapidly depleting rental stock. Aimed at retrofit program administrators and building science professionals, this research project investigates the possibility of using prescriptive retrofit packages as a time- and resource-effective approach to the process of retrofitting multifamily buildings.

Evaluation of CNT Energy Savers Retrofit Packages Implemented in Multifamily Buildings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Farley, Jenne; Ruch, Russell

This evaluation explored the feasibility of designing prescriptive retrofit measure packages for typical Chicago region multifamily buildings in order to achieve 25%-30% source energy savings through the study of three case studies. There is an urgent need to scale up energy efficiency retrofitting of Chicago's multifamily buildings in order to address rising energy costs and a rapidly depletingrental stock. Aimed at retrofit program administrators and building science professionals, this research project investigates the possibility of using prescriptive retrofit packages as a time- and resource-effective approach to the process of retrofitting multifamily buildings.

The Family Expedition Program: Adventure Family Therapy in the Home As Well As in the Outdoors.

ERIC Educational Resources Information Center

Gass, Michael; Dolcino, Carina

The Family Expedition is a federally funded program designed to foster healthy changes in families with troubled adolescents through multifamily adventure therapy experiences. Each Family Expedition cycle is 4 months long, consisting of six multifamily sessions and three home visits. Each 90-minute home visit gives families time to focus on…

Transitioning Together: A Multi-Family Group Psychoeducation Program for Adolescents with ASD and Their Parents

ERIC Educational Resources Information Center

DaWalt, Leann Smith; Greenberg, Jan S.; Mailick, Marsha R.

2018-01-01

Currently there are few evidence-based programs available for families of individuals with ASD during the transition to adulthood. The present study provided a preliminary evaluation of a multi-family group psychoeducation intervention using a randomized waitlist control design (n = 41). Families in the intervention condition participated in…

24 CFR Appendix to Subpart M of... - Equal Housing Opportunity Insignia

Code of Federal Regulations, 2010 CFR

2010-04-01

... advertising and marketing program in which there are no barriers to obtaining housing because of race, color... HOUSING AND URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Affirmative Fair Housing Marketing...

Multifamily Building Operator Job/Task Analysis and Report: September 2013

DOE Office of Scientific and Technical Information (OSTI.GOV)

Owens, C. M.

The development of job/task analyses (JTAs) is one of three components of the Guidelines for Home Energy Professionals project and will allow industry to develop training resources, quality assurance protocols, accredited training programs, and professional certifications. The Multifamily Building Operator JTA identifies and catalogs all of the tasks performed by multifamily building operators, as well as the knowledge, skills, and abilities (KSAs) needed to perform the identified tasks.

Multifamily Energy Auditor Job/Task Analysis and Report: September 2013

DOE Office of Scientific and Technical Information (OSTI.GOV)

Owens, C. M.

The development of job/task analyses (JTAs) is one of three components of the Guidelines for Home Energy Professionals project and will allow industry to develop training resources, quality assurance protocols, accredited training programs, and professional certifications. The Multifamily Energy Auditor JTA identifies and catalogs all of the tasks performed by multifamily energy auditors, as well as the knowledge, skills, and abilities (KSAs) needed to perform the identified tasks.

The FhaB/FhaC two-partner secretion system is involved in adhesion of Acinetobacter baumannii AbH12O-A2 strain

PubMed Central

Pérez, A.; Merino, M.; Rumbo-Feal, S.; Álvarez-Fraga, L.; Vallejo, J. A.; Beceiro, A.; Ohneck, E. J.; Mateos, J.; Fernández-Puente, P.; Actis, L. A.; Poza, M.; Bou, G.

2017-01-01

ABSTRACT Acinetobacter baumannii is a hospital-acquired pathogen that shows an extraordinary capacity to stay in the hospital environment. Adherence of the bacteria to eukaryotic cells or to abiotic surfaces is the first step for establishing an infection. The A. baumannii strain AbH12O-A2 showed an exceptional ability to adhere to A549 epithelial cells. The AbFhaB/FhaC 2-partner secretion (TPS) system involved in adhesion was discovered after the screening of the recently determined A. baumannii AbH12O-A2 strain genome (CP009534.1). The AbFhaB is a large exoprotein which transport to the bacterial surface is mediated by the AbFhaC protein. In the present study, the role of this TPS system in the AbH12O-A2 adherence phenotype was investigated. The functional inactivation of this 2-partner secretion system was addressed by analyzing the outer membrane vesicles (OMV) proteomic profile from the wild-type strain and its derivative mutant AbH12O-A2ΔfhaC demonstrating that AbFhaB is no longer detected in the absence of AbFhaC. Scanning electron microscopy (SEM) and adhesion experiments demonstrated that inactivation of the AbFhaB/FhaC system significantly decreases bacterial attachment to A549 alveolar epithelial cells. Moreover, it has been demonstrated that this 2-partner secretion system is involved in fibronectin-mediated adherence of the A. baumannii AbH12O-A2 isolate. Finally, we report that the AbFhaB/FhaC system is involved in virulence when tested using invertebrate and vertebrate hosts. These data suggest the potential role that this AbFhaB/FhaC secretion system could play in the pathobiology of A. baumannii. PMID:27858524

The FhaB/FhaC two-partner secretion system is involved in adhesion of Acinetobacter baumannii AbH12O-A2 strain.

PubMed

Pérez, A; Merino, M; Rumbo-Feal, S; Álvarez-Fraga, L; Vallejo, J A; Beceiro, A; Ohneck, E J; Mateos, J; Fernández-Puente, P; Actis, L A; Poza, M; Bou, G

2017-08-18

Acinetobacter baumannii is a hospital-acquired pathogen that shows an extraordinary capacity to stay in the hospital environment. Adherence of the bacteria to eukaryotic cells or to abiotic surfaces is the first step for establishing an infection. The A. baumannii strain AbH12O-A2 showed an exceptional ability to adhere to A549 epithelial cells. The AbFhaB/FhaC 2-partner secretion (TPS) system involved in adhesion was discovered after the screening of the recently determined A. baumannii AbH12O-A2 strain genome (CP009534.1). The AbFhaB is a large exoprotein which transport to the bacterial surface is mediated by the AbFhaC protein. In the present study, the role of this TPS system in the AbH12O-A2 adherence phenotype was investigated. The functional inactivation of this 2-partner secretion system was addressed by analyzing the outer membrane vesicles (OMV) proteomic profile from the wild-type strain and its derivative mutant AbH12O-A2ΔfhaC demonstrating that AbFhaB is no longer detected in the absence of AbFhaC. Scanning electron microscopy (SEM) and adhesion experiments demonstrated that inactivation of the AbFhaB/FhaC system significantly decreases bacterial attachment to A549 alveolar epithelial cells. Moreover, it has been demonstrated that this 2-partner secretion system is involved in fibronectin-mediated adherence of the A. baumannii AbH12O-A2 isolate. Finally, we report that the AbFhaB/FhaC system is involved in virulence when tested using invertebrate and vertebrate hosts. These data suggest the potential role that this AbFhaB/FhaC secretion system could play in the pathobiology of A. baumannii.

Identification of Ser/Thr kinase and Forkhead Associated Domains in Mycobacterium ulcerans: Characterization of Novel Association between Protein Kinase Q and MupFHA

PubMed Central

Singhal, Anshika; Joshi, Jayadev; Virmani, Richa; Gupta, Meetu; Verma, Nupur; Maji, Abhijit; Misra, Richa; Baronian, Grégory; Pandey, Amit K.; Molle, Virginie; Singh, Yogendra

2014-01-01

Background Mycobacterium ulcerans, the causative agent of Buruli ulcer in humans, is unique among the members of Mycobacterium genus due to the presence of the virulence determinant megaplasmid pMUM001. This plasmid encodes multiple virulence-associated genes, including mup011, which is an uncharacterized Ser/Thr protein kinase (STPK) PknQ. Methodology/Principal Findings In this study, we have characterized PknQ and explored its interaction with MupFHA (Mup018c), a FHA domain containing protein also encoded by pMUM001. MupFHA was found to interact with PknQ and suppress its autophosphorylation. Subsequent protein-protein docking and molecular dynamic simulation analyses showed that this interaction involves the FHA domain of MupFHA and PknQ activation loop residues Ser170 and Thr174. FHA domains are known to recognize phosphothreonine residues, and therefore, MupFHA may be acting as one of the few unusual FHA-domain having overlapping specificity. Additionally, we elucidated the PknQ-dependent regulation of MupDivIVA (Mup012c), which is a DivIVA domain containing protein encoded by pMUM001. MupDivIVA interacts with MupFHA and this interaction may also involve phospho-threonine/serine residues of MupDivIVA. Conclusions/Significance Together, these results describe novel signaling mechanisms in M. ulcerans and show a three-way regulation of PknQ, MupFHA, and MupDivIVA. FHA domains have been considered to be only pThr specific and our results indicate a novel mechanism of pSer as well as pThr interaction exhibited by MupFHA. These results signify the need of further re-evaluating the FHA domain –pThr/pSer interaction model. MupFHA may serve as the ideal candidate for structural studies on this unique class of modular enzymes. PMID:25412098

Hyperandrogenism in female athletes with functional hypothalamic amenorrhea: a distinct phenotype

PubMed Central

Javed, Asma; Kashyap, Rahul; Lteif, Aida N

2015-01-01

Objective To compare the reproductive, metabolic, and skeletal profiles of young athletic women with functional hypothalamic amenorrhea (FHA) as well as clinical or biochemical hyperandrogenism (FHA-EX+HA) with body mass index matched women with FHA due to exercise (FHA-EX) or anorexia nervosa (FHA-AN) alone. Design Retrospective cohort study. Setting Tertiary care teaching hospital. Population Adolescents and young women, 15–30 years of age, diagnosed with FHA along with concurrent signs of hyperandrogenism (n=22) and body mass index matched control groups consisting of 22 women in each group of FHA-EX and FHA-AN. Main outcomes 1) Reproductive hormone profile: luteinizing hormone (LH), follicle stimulating hormone (FSH), total testosterone, pelvic ultrasound features. 2) Metabolic function and skeletal health markers: fasting glucose, cholesterol, number of stress fractures and bone mineral density as assessed by spine dual-energy X-ray absorptiometry z scores. Results FHA-EX+HA group was older at diagnosis compared to the other groups with a median (interquartile range [IQR]) age of 22 (18.75–25.25) years versus (vs) 17.5 (15.75–19) for FHA-EX; (P<0.01) and 18 (16–22.25) years for FHA-AN (P=0.01). There were no differences among the groups based on number of hours of exercise per week, type of physical activity or duration of amenorrhea. Median (IQR) LH/FSH ratio was higher in FHA-EX+HA than both other groups, 1.44 (1.03–1.77) vs 0.50 (0.20–0.94) for FHA-EX and 0.67 (0.51–0.87) for FHA-AN (P<0.01 for both). Total testosterone concentrations were not different among the groups. Median (IQR) fasting serum glucose concentration was higher in FHA-EX+HA vs FHA-EX, 88.5 mg/dL (82.8–90 mg/dL) vs 83.5 mg/dL (78.8–86.3 mg/dL) (P=0.01) but not different from FHA-AN (P=0.31). Percentage of women with stress fractures was lower in FHA-EX+HA (4.5%) as compared to both FHA-EX (27.3%) and FHA-AN (50%); P=0.04 and 0.01 respectively. The LH/FSH ratio was weakly positively associated with serum glucose (adjusted r2=0.102; P=0.01) as well as with dual-energy X-ray absorptiometry spine score (adjusted r2=0.191; P=0.04) in the entire cohort. Conclusion In a small cohort of female athletes with hyperandrogenism, a distinct reproductive hormone profile consisting of higher LH to FHS ratio may be associated with adverse metabolic health markers but improved skeletal health. PMID:25610004

Multifamily Quality Control Inspector Job/Task Analysis and Report: September 2013

DOE Office of Scientific and Technical Information (OSTI.GOV)

Owens, C. M.

The development of job/task analyses (JTAs) is one of three components of the Guidelines for Home Energy Professionals project and will allow industry to develop training resources, quality assurance protocols, accredited training programs, and professional certifications. The Multifamily Quality Control Inspector JTA identifies and catalogs all of the tasks performed by multifamily quality control inspectors, as well as the knowledge, skills, and abilities (KSAs) needed to perform the identified tasks.

Multifamily Retrofit Project Manager Job/Task Analysis and Report: September 2013

DOE Office of Scientific and Technical Information (OSTI.GOV)

Owens, C. M.

The development of job/task analyses (JTAs) is one of three components of the Guidelines for Home Energy Professionals project and will allow industry to develop training resources, quality assurance protocols, accredited training programs, and professional certifications. The Multifamily Retrofit Project Manager JTA identifies and catalogs all of the tasks performed by multifamily retrofit project managers, as well as the knowledge, skills, and abilities (KSAs) needed to perform the identified tasks.

Families and Schools Together: An Experimental Study of Multi-Family Support Groups for Children At Risk

ERIC Educational Resources Information Center

Kratochwill, Thomas R.; McDonald, Lynn; Levin, Joel R.; Scalia, Phyllis A.; Coover, Gail

2009-01-01

We evaluated a multi-family support group intervention program in elementary schools. Kindergarten through third-grade children at eight urban schools in a Midwestern university community were universally invited to participate in the Families and Schools Together (FAST) program, and made up half of the study participants; the other half were K-3…

24 CFR 401.403 - Rejection of a request for a Restructuring Plan because of actions or omissions of owner or...

Code of Federal Regulations, 2012 CFR

2012-04-01

...) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM (MARK-TO...

24 CFR 401.403 - Rejection of a request for a Restructuring Plan because of actions or omissions of owner or...

Code of Federal Regulations, 2011 CFR

2011-04-01

...) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM (MARK-TO...

24 CFR 401.403 - Rejection of a request for a Restructuring Plan because of actions or omissions of owner or...

Code of Federal Regulations, 2014 CFR

2014-04-01

...) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM (MARK-TO...

Families and Schools Together: An Experimental Analysis of a Parent-Mediated Multi-Family Group Program for American Indian Children

ERIC Educational Resources Information Center

Kratochwill, T.R.; McDonald, L.; Levin, J.R.; Young Bear-Tibbetts, H.; Demaray, M.K.

2004-01-01

The goals of this randomized intervention study were to: (a) increase academic performance among American Indian children ages 4-9 years and (b) reduce classroom problem behaviors. To achieve these goals, the multi-family group program called Families and Schools Together (FAST) was adapted with three American Indian Nations in Wisconsin. Over 3…

Xanthomonas filamentous hemagglutinin-like protein Fha1 interacts with pepper hypersensitive-induced reaction protein CaHIR1 and functions as a virulence factor in host plants.

PubMed

Choi, Hyong Woo; Kim, Dae Sung; Kim, Nak Hyun; Jung, Ho Won; Ham, Jong Hyun; Hwang, Byung Kook

2013-12-01

Pathogens have evolved a variety of virulence factors to infect host plants successfully. We previously identified the pepper plasma-membrane-resident hypersensitive-induced reaction protein (CaHIR1) as a regulator of plant disease- and immunity-associated cell death. Here, we identified the small filamentous hemagglutinin-like protein (Fha1) of Xanthomonas campestris pv. vesicatoria as an interacting partner of CaHIR1 using yeast two-hybrid screening. Coimmunoprecipitation and bimolecular fluorescence complementation experiments revealed that Fha1 specifically interacts with CaHIR1 in planta. The endocytic tracker FM4-64 staining showed that the CaHIR1-Fha1 complex localizes in the endocytic vesicle-like structure. The X. campestris pv. vesicatoria Δfha1 mutant strain exhibited significantly increased surface adherence but reduced swarming motility. Mutation of fha1 inhibited the growth of X. campestris pv. vesicatoria and X. campestris pv. vesicatoria ΔavrBsT in tomato and pepper leaves, respectively, suggesting that Fha1 acts as a virulence factor in host plants. Transient expression of fha1 and also infiltration with purified Fha1 proteins induced disease-associated cell death response through the interaction with CaHIR1 and suppressed the expression of pathogenesis-related (PR) genes. Silencing of CaHIR1 in pepper significantly reduced ΔavrBsT growth and Fha1-triggered susceptibility cell death. Overexpression of fha1 in Arabidopsis retarded plant growth and triggered disease-associated cell death, resulting in altered disease susceptibility. Taken together, these results suggest that the X. campestris pv. vesicatoria virulence factor Fha1 interacts with CaHIR1, induces susceptibility cell death, and suppresses PR gene expression in host plants.

24 CFR 200.61 - Title.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Commissioner. (c) Endorsement of the credit instrument for insurance shall evidence the acceptability of title... GENERAL INTRODUCTION TO FHA PROGRAMS Requirements for Application, Commitment, and Endorsement Generally...

7 CFR 2003.18 - Functional organization of RHS.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Property Management Division, and Single Family Housing Centralized Servicing Center in St. Louis, Mo. (i... credit reports, and, site development. (ii) Multi-Family Housing Portfolio Management Division. Headed by... the management and servicing of the nationwide Multi-Family Housing programs. The Division implements...

76 FR 42688 - Updating State Residential Building Energy Efficiency Codes

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-19

... 19, 2013. ADDRESSES: Certification Statements must be addressed to the Buildings Technologies Program...-rise (greater than three stories) multifamily residential buildings and hotel, motel, and other..., townhouses, row houses, and low-rise multifamily buildings (not greater than three stories) such as...

Replacing Resistance Heating with Mini-Split Heat Pumps, Sharon, Connecticut (Fact Sheet)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

Mini-split heat pumps can provide space heating and cooling in many climates and are relatively affordable. These and other features make them potentially suitable for retrofitting into multifamily buildings in cold climates to replace electric resistance heating or other outmoded heating systems. This report investigates the suitability of mini-split heat pumps for multifamily retrofits. Various technical and regulatory barriers are discussed and modeling was performed to compare long-term costs of substituting mini-splits for a variety of other heating and cooling options. A number of utility programs have retrofit mini-splits in both single family and multifamily residences. Two such multifamily programsmore » are discussed in detail.« less

24 CFR 200.3 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... which has been insured by the endorsement of the credit instrument by the Commissioner, or the... GENERAL INTRODUCTION TO FHA PROGRAMS Requirements for Application, Commitment, and Endorsement Generally...

76 FR 52676 - Notice of Proposed Information Collection: Comment Request; Multifamily Financial Management...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-23

... housing program participants to submit financial data electronically, using generally accepted accounting principles, in a prescribed format. HUD collects the financial information from participants to evaluate the... Information Collection: Comment Request; Multifamily Financial Management Template AGENCY: Office of the...

24 CFR 401.480 - Sale or transfer of project.

Code of Federal Regulations, 2013 CFR

2013-04-01

... Development (Continued) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE RESTRUCTURING PROGRAM (MARK-TO-MARKET) Restructuring Plan § 401.480 Sale or transfer of project. (a) May the owner...

75 FR 23582 - Federal Housing Administration: Continuation of FHA Reform-Strengthening Risk Management Through...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-04

...-AI81 Federal Housing Administration: Continuation of FHA Reform-- Strengthening Risk Management Through... Federal Housing Administration (FHA) that are designed to strengthen FHA by improving its management of risk. Although the preamble to the final rule correctly provides that the revised net worth...

24 CFR 200.54 - Project completion funding.

Code of Federal Regulations, 2010 CFR

2010-04-01

... URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Requirements for Application, Commitment, and... project and to pay the initial service charge, carrying charges, and legal and organizational expenses...

24 CFR 572.105 - Financing the purchase of properties by eligible families.

Code of Federal Regulations, 2010 CFR

2010-04-01

... DEVELOPMENT, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT COMMUNITY FACILITIES HOPE FOR HOMEOWNERSHIP OF SINGLE FAMILY HOMES PROGRAM (HOPE 3) Homeownership Program Requirements-Implementation Grants § 572.105... insurance apply to mortgages insured by FHA on properties assisted under the HOPE 3 program. Exceptions in...

Mood disorders and sexual functioning in women with functional hypothalamic amenorrhea.

PubMed

Dundon, Carolyn M; Rellini, Alessandra H; Tonani, Silvia; Santamaria, Valentina; Nappi, Rosella

2010-11-01

To investigate the sexual function of women with functional hypothalamic amenorrhea (FHA) and to test the mediating effects of depression and anxiety on the sexual functioning of women with FHA. In this cross-sectional study, participants completed questionnaires on sexual function, depression, and anxiety. Tertiary care university hospital. Women with (n=41) and without (n=39) FHA recruited from a gynecologic endocrinology unit. None. The McCoy Female Sexuality Questionnaire assessed sexual function, and the Zung Scale measured depression and anxiety. Women with FHA experienced more sexual function problems and significantly higher depression and anxiety compared to women without menstrual dysfunction. In addition, depression offered a significant explanation for the sexual problems experienced by women with FHA. The psychologic symptoms that contribute to the onset of FHA partially mediate the relationship between FHA and sexual dysfunction. Copyright © 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

78 FR 41075 - Federal Housing Administration (FHA): Single Family Quality Assurance-Solicitation of Information...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-09

... the efficiency and effectiveness of FHA's quality assurance process (QAP). The objective of FHA's QAP... control plan (QCP).\\1\\ A copy of the plan must be submitted by the lender when applying for FHA lender... processes: post-endorsement technical reviews, Quality Assurance Division reviews and targeted lender...

78 FR 75238 - Federal Housing Administration (FHA) Risk Management Initiatives: New Manual Underwriting...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-11

...-AJ07 Federal Housing Administration (FHA) Risk Management Initiatives: New Manual Underwriting... the number of claims. FHA can control costs through risk management practices. The lower costs are a... insurance claim rates and risk of loss to FHA. \\1\\ U.S. Department of Housing and Urban Development, Annual...

Mechanistic insights into phosphoprotein-binding FHA domains.

PubMed

Liang, Xiangyang; Van Doren, Steven R

2008-08-01

[Structure: see text]. FHA domains are protein modules that switch signals in diverse biological pathways by monitoring the phosphorylation of threonine residues of target proteins. As part of the effort to gain insight into cellular avoidance of cancer, FHA domains involved in the cellular response to DNA damage have been especially well-characterized. The complete protein where the FHA domain resides and the interaction partners determine the nature of the signaling. Thus, a key biochemical question is how do FHA domains pick out their partners from among thousands of alternatives in the cell? This Account discusses the structure, affinity, and specificity of FHA domains and the formation of their functional structure. Although FHA domains share sequence identity at only five loop residues, they all fold into a beta-sandwich of two beta-sheets. The conserved arginine and serine of the recognition loops recognize the phosphorylation of the threonine targeted. Side chains emanating from loops that join beta-strand 4 with 5, 6 with 7, or 10 with 11 make specific contacts with amino acids of the ligand that tailor sequence preferences. Many FHA domains choose a partner in extended conformation, somewhat according to the residue three after the phosphothreonine in sequence (pT + 3 position). One group of FHA domains chooses a short carboxylate-containing side chain at pT + 3. Another group chooses a long, branched aliphatic side chain. A third group prefers other hydrophobic or uncharged polar side chains at pT + 3. However, another FHA domain instead chooses on the basis of pT - 2, pT - 3, and pT + 1 positions. An FHA domain from a marker of human cancer instead chooses a much longer protein fragment that adds a beta-strand to its beta-sheet and that presents hydrophobic residues from a novel helix to the usual recognition surface. This novel recognition site and more remote sites for the binding of other types of protein partners were predicted for the entire family of FHA domains by a bioinformatics approach. The phosphopeptide-dependent dynamics of an FHA domain, SH2 domain, and PTB domain suggest a common theme: rigid, preformed binding surfaces support van der Waals contacts that provide favorable binding enthalpy. Despite the lack of pronounced conformational changes in FHA domains linked to binding events, more subtle adjustments may be possible. In the one FHA domain tested, phosphothreonine peptide binding is accompanied by increased flexibility just outside the binding site and increased rigidity across the beta-sandwich. The folding of the same FHA domain progresses through near-native intermediates that stabilize the recognition loops in the center of the phosphoprotein-binding surface; this may promote rigidity in the interface and affinity for targets phosphorylated on threonine.

24 CFR 200.1101 - Cross-reference.

Code of Federal Regulations, 2010 CFR

2010-04-01

... URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Social Security Numbers and Employer Identification Numbers; Applicants in Unassisted Programs § 200.1101 Cross-reference. The provisions in subpart B of part 5 of this title apply to Social Security Numbers and Employer Identification Numbers for...

75 FR 37825 - Notice of Proposed Information Collection: Comment Request; Minimum Property Standards for...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-30

... Information Collection: Comment Request; Minimum Property Standards for Multifamily and Care-Type Facilities...: Minimum Property Standards for Multifamily and Care-type facilities. OMB Control Number, if applicable... Housing and Urban Development (HUD) developed the Minimum Property Standards (MPS) program in order to...

24 CFR 510.1 - Multi-family property loans.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 3 2011-04-01 2010-04-01 true Multi-family property loans. 510.1 Section 510.1 Housing and Urban Development Regulations Relating to Housing and Urban Development... URBAN DEVELOPMENT SLUM CLEARANCE AND URBAN RENEWAL SECTION 312 REHABILITATION LOAN PROGRAM § 510.1 Multi...

Strong Military Families Program: A Multifamily Group Approach to Strengthening Family Resilience

ERIC Educational Resources Information Center

Rosenblum, Kate; Muzik, Maria; Waddell, Rachel; Thompson, Stephanie; Rosenberg, Lauren; Masini, Gabriella; Smith, Karen

2015-01-01

Military families frequently display remarkable resilience in the face of significant challenges, and yet deployment and parental separation are significant stressors for parents, particularly those with infants and young children. The Strong Military Families preventive intervention is a multifamily parenting and self-care skills group that aims…

Increased cortisol in the cerebrospinal fluid of women with functional hypothalamic amenorrhea.

PubMed

Brundu, Benedetta; Loucks, Tammy L; Adler, Lauri J; Cameron, Judy L; Berga, Sarah L

2006-04-01

The proximate cause of functional hypothalamic amenorrhea (FHA) is reduced GnRH drive. The concomitant increase in circulating cortisol suggests that psychogenic stress plays an etiologic role, but others have argued for a strictly metabolic cause, such as undernutrition or excessive exercise. Indeed, our finding that the cerebrospinal fluid (CSF) concentration of CRH was not elevated in FHA cast doubt about the extent of hypothalamic-pituitary-adrenal activation in FHA and, therefore, we wondered whether central cortisol levels were elevated. We tested the null hypothesis that CSF cortisol levels would be comparable in FHA and eumenorrheic women (EW). The study is a cross-sectional comparison. The study was set in a general clinical research center at an academic medical center. Fifteen women with FHA who were of normal body weight and 14 EW participated. Blood samples were collected at 15-min intervals for 24 h, followed by procurement of 25 ml CSF. Cortisol, cortisol-binding globulin (CBG), and SHBG levels in blood and CSF were the main outcome measures. CSF cortisol concentrations were 30% greater when serum cortisol was 16% higher in FHA compared with EW. Circulating CBG, but not SHBG, was increased in FHA and, thus, the circulating free cortisol index was similar in FHA and EW. Because CBG and SHBG were nil in CSF, the increase in CSF cortisol in FHA was unbound. The hypothalamic-pituitary-adrenal axis is activated in FHA. The maintenance of CRH drive despite increased CSF cortisol indicates resistance to cortisol feedback inhibition. The mechanisms mediating feedback resistance likely involve altered hippocampal corticosteroid reception and serotonergic and GABAergic neuromodulation.

24 CFR 200.77 - Lead-based paint poisoning prevention.

Code of Federal Regulations, 2010 CFR

2010-04-01

... prevention. 200.77 Section 200.77 Housing and Urban Development Regulations Relating to Housing and Urban... HOUSING AND URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Requirements for Application...-based paint poisoning prevention. Requirements set forth in 24 CFR part 35 apply to these programs. ...

24 CFR 200.610 - Policy.

Code of Federal Regulations, 2010 CFR

2010-04-01

... GENERAL INTRODUCTION TO FHA PROGRAMS Affirmative Fair Housing Marketing Regulations § 200.610 Policy. It... condition in which individuals of similar income levels in the same housing market area have a like range of... programs shall pursue affirmative fair housing marketing policies in soliciting buyers and tenants, in...

24 CFR 200.934 - User fee system for the technical suitability of products program.

Code of Federal Regulations, 2010 CFR

2010-04-01

... COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Minimum Property... section establishes fee requirements for the issuance of Structural Engineering Bulletins (SEBs), Mechanical Engineering Bulletins (MEBs), Truss Connector Bulletins (TCBs), Area Letters of Acceptance (ALAs...

76 FR 17428 - Notice of Submission of Proposed Information Collection to OMB Rehabilitation Mortgage Insurance...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-29

... Proposed Information Collection to OMB Rehabilitation Mortgage Insurance Underwriting Program Section 203(K... processes for participants in HUD-FHA's 203(K) Rehabilitation Mortgage Insurance Program. DATES: Comments... Program Section 203(K). OMB Approval Number: 2502-0527. Form Numbers: HUD-92700, HUD-92700-A, HUD-9746-A...

Heart rate variability in adolescents with functional hypothalamic amenorrhea and anorexia nervosa.

PubMed

Bomba, Monica; Corbetta, Fabiola; Gambera, Alessandro; Nicosia, Franco; Bonini, Luisa; Neri, Francesca; Tremolizzo, Lucio; Nacinovich, Renata

2014-02-28

Aim of this study consisted in assessing the 24-h heart rate variability (HRV), a measure of autonomic nervous system (ANS) imbalance, in 21 adolescents with functional hypothalamic amenorrhea (FHA, 11 normogonadotropic, N-FHA, and 10 hypogonadotropic, Hy-FHA) compared to 21 patients with anorexia nervosa (AN) and 21 controls. As expected, subjects with AN showed a significant dysregulation in multiple HRV parameters, while Hy-FHA patients presented with a dysregulation in a few domains (SDNN, HFr), which was not present in girls with N-FHA, who showed values largely similar to controls. FHA might represent part of the AN biological spectrum, and a link between these two conditions might exist, possibly related to the degree of psychological and/or hormonal dysfunction. © 2013 Published by Elsevier Ireland Ltd.

24 CFR 200.233 - Effect and requirement of approval.

Code of Federal Regulations, 2010 CFR

2010-04-01

... HOUSING AND URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Participation and Compliance... this part for participation only for a specific project in a specific role. Approval of a principal...

76 FR 29258 - Availability (NOFA) for HUD's Fiscal Year (FY) 2011 Asthma Interventions in Public and Assisted...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-20

... Interventions in Public and Assisted Multifamily Housing Program AGENCY: Office of Healthy Homes and Lead Hazard... Funding Availability (NOFA) for HUD's Fiscal Year (FY) 2011 Asthma Interventions in Public and Assisted... Availability (NOFA) for the Fiscal Year (FY) 2011 Asthma Interventions in Public and Assisted Multifamily...

A refined technique to calculate finite helical axes from rigid body trackers.

PubMed

McLachlin, Stewart D; Ferreira, Louis M; Dunning, Cynthia E

2014-12-01

Finite helical axes (FHAs) are a potentially effective tool for joint kinematic analysis. Unfortunately, no straightforward guidelines exist for calculating accurate FHAs using prepackaged six degree-of-freedom (6 DOF) rigid body trackers. Thus, this study aimed to: (1) describe a protocol for calculating FHA parameters from 6 DOF rigid body trackers using the screw matrix and (2) to maximize the number of accurate FHAs generated from a given data set using a moving window analysis. Four Optotrak® Smart Markers were used as the rigid body trackers, two moving and two fixed, at different distances from the hinge joint of a custom-machined jig. 6D OF pose information was generated from 51 static positions of the jig rotated and fixed in 0.5 deg increments up to 25 deg. Output metrics included the FHA direction cosines, the rotation about the FHA, the translation along the axis, and the intercept of the FHA with the plane normal to the jig's hinge joint. FHA metrics were calculated using the relative tracker rotation from the starting position, and using a moving window analysis to define a minimum acceptable rotational displacement between the moving tracker data points. Data analysis found all FHA rotations calculated from the starting position were within 0.15 deg of the prescribed jig rotation. FHA intercepts were most stable when determined using trackers closest to the hinge axis. Increasing the moving window size improved the FHA direction cosines and center of rotation accuracy. Window sizes larger than 2 deg had an intercept deviation of less than 1 mm. Furthermore, compared to the 0 deg window size, the 2 deg window had a 90% improvement in FHA intercept precision while generating almost an equivalent number of FHA axes. This work identified a solution to improve FHA calculations for biomechanical researchers looking to describe changes in 3D joint motion.

Quantifying the Financial Benefits of Multifamily Retrofits

DOE Office of Scientific and Technical Information (OSTI.GOV)

Philbrick, D.; Scheu, R.; Brand, L.

Increasing the adoption of energy efficient building practices will require the energy sector to increase their understanding of the way that retrofits affect multifamily financial performance as well as how those indicators are interpreted by the lending and appraisal industries. This project analyzed building, energy, and financial program data as well as other public and private data to examine the relationship between energy efficiency retrofits and financial performance on three levels: building, city, and community. The project goals were to increase the data and analysis in the growing body of multifamily financial benefits work as well provide a framework formore » other geographies to produce similar characterization. The goals are accomplished through three tasks. Task one: A pre- and post-retrofit analysis of thirteen Chicago multifamily buildings. Task two: A comparison of Chicago income and expenses to two national datasets. Task three: An in-depth look at multifamily market sales data and the subsequent impact of buildings that undergo retrofits.« less

Building America Case Study: Quantifying the Financial Benefits of Multifamily Retrofits, Chicago, Illinois

DOE Office of Scientific and Technical Information (OSTI.GOV)

Increasing the adoption of energy efficient building practices will require the energy sector to increase their understanding of the way that retrofits affect multifamily financial performance as well as how those indicators are interpreted by the lending and appraisal industries. This project analyzed building, energy, and financial program data as well as other public and private data to examine the relationship between energy efficiency retrofits and financial performance on three levels: building, city, and community. The project goals were to increase the data and analysis in the growing body of multifamily financial benefits work as well provide a framework formore » other geographies to produce similar characterization. The goals are accomplished through three tasks: Task one: A pre- and post-retrofit analysis of thirteen Chicago multifamily buildings. Task two: A comparison of Chicago income and expenses to two national datasets. Task three: An in-depth look at multifamily market sales data and the subsequent impact of buildings that undergo retrofits.« less

Does polycystic ovarian morphology influence the response to treatment with pulsatile GnRH in functional hypothalamic amenorrhea?

PubMed

Dumont, Agathe; Dewailly, Didier; Plouvier, Pauline; Catteau-Jonard, Sophie; Robin, Geoffroy

2016-04-29

Pulsatile GnRH therapy is the gold standard treatment for ovulation induction in women having functional hypothalamic amenorrhea (FHA). The use of pulsatile GnRH therapy in FHA patients with polycystic ovarian morphology (PCOM), called "FHA-PCOM", has been little studied in the literature and results remain contradictory. The aim of this study was to compare the outcomes of pulsatile GnRH therapy for ovulation induction between FHA and "FHA-PCOM" patients in order to search for an eventual impact of PCOM. Retrospective study from August 2002 to June 2015, including 27 patients with FHA and 40 "FHA-PCOM" patients (85 and 104 initiated cycles, respectively) treated by pulsatile GnRH therapy for induction ovulation. The two groups were similar except for markers of PCOM (follicle number per ovary, serum Anti-Müllerian Hormone level and ovarian area), which were significantly higher in patients with "FHA-PCOM". There was no significant difference between the groups concerning the ovarian response: with equivalent doses of GnRH, both groups had similar ovulation (80.8 vs 77.7 %, NS) and excessive response rates (12.5 vs 10.6 %, NS). There was no significant difference in on-going pregnancy rates (26.9 vs 20 % per initiated cycle, NS), as well as in miscarriage, multiple pregnancy or biochemical pregnancy rates. Pulsatile GnRH seems to be a successful and safe method for ovulation induction in "FHA-PCOM" patients. If results were confirmed by prospective studies, GnRH therapy could therefore become a first-line treatment for this specific population, just as it is for women with FHA without PCOM.

Genetic analysis of a region of the Bordetella pertussis chromosome encoding filamentous hemagglutinin and the pleiotropic regulatory locus vir.

PubMed Central

Stibitz, S; Weiss, A A; Falkow, S

1988-01-01

The vir locus of Bordetella pertussis apparently encodes a trans-acting positive regulator that is required for the coordinate expression of genes associated with virulence: pertussis toxin, filamentous hemagglutinin (FHA), hemolysin, and adenylate cyclase toxin. DNA clones of vir and of genes required for the synthesis of some of the factors under vir control were obtained with DNA probes from the chromosomal DNA surrounding sites of Tn5 insertion mutations that inactivated those genes. Two vir clones were found which also contained genes required for the proper expression of FHA in B. pertussis. The plasmids which contained both the fha and vir genes expressed immunologically reactive FHA in Escherichia coli, as detected by colony blots, whereas plasmids which contained only fha or vir were negative in this assay. The regulation of FHA production in E. coli, as in B. pertussis, was temperature dependent and inhibited by high concentrations of either magnesium ions or nicotinic acid, indicating that the sequences cloned in E. coli contained the information required to preserve the physiological responses seen in B. pertussis. Further characterization of the vir-fha clones by Tn5 mutagenesis in E. coli and by the return of cloned sequences to B. pertussis in trans and to the B. pertussis chromosome led to the localization of the vir locus, the structural gene for FHA, and genes that are possibly required for the synthesis and export of FHA. Images PMID:2898470

Psychopathological traits of adolescents with functional hypothalamic amenorrhea: a comparison with anorexia nervosa.

PubMed

Bomba, Monica; Corbetta, Fabiola; Bonini, Luisa; Gambera, Alessandro; Tremolizzo, Lucio; Neri, Francesca; Nacinovich, Renata

2014-03-01

Functional hypothalamic amenorrhea (FHA) is a form of anovulation, due to the suppression of hypothalamic-pituitary-ovarian axis, not related to identifiable organic causes. Like adolescents with anorexia nervosa (AN), subjects with FHA show dysfunctional attitudes, low self-esteem, depressive mood, anxiety and inability to cope with daily stress. The aim of the study is to examine similarities and differences between FHA and AN in terms of clinical profiles and psychological variables. 21 adolescents with FHA, 21 adolescents with anorexia nervosa, and 21 healthy adolescents were included in the study. All the teenagers completed a battery of self-administered psychological tests for the detection of behaviors and symptoms attributable to the presence of an eating disorder (EDI-2), depression (CDI), and alexithymia (TAS-20). Different from healthy controls, subjects with FHA and with AN shared common psychopathological aspects, such as maturity issues, social insecurity and introversion, a tendency to depression, excessive concerns with dieting, and fear of gaining weight. Nevertheless, adolescents with AN presented a more profound psychopathological disorder as observed at test comparisons with subjects with FHA. Results show a clinical spectrum that includes AN and FHA and suggest the necessity to treat FHA with a multidisciplinary approach for both organic and psychological aspects.

Functional hypothalamic amenorrhea: current view on neuroendocrine aberrations.

PubMed

Meczekalski, Blazej; Podfigurna-Stopa, Agnieszka; Warenik-Szymankiewicz, Alina; Genazzani, Andrea Riccardo

2008-01-01

Functional hypothalamic amenorrhea (FHA) is defined as a non-organic and reversible disorder in which the impairment of gonadotropin-releasing hormone (GnRH) pulsatile secretion plays a key role. There are main three types of FHA: stress-related amenorrhea, weight loss-related amenorrhea and exercise-related amenorrhea. The spectrum of GnRH-luteinizing hormone (LH) disturbances in FHA is very broad and includes lower mean frequency of LH pulses, complete absence of LH pulsatility, normal-appearing secretion pattern and higher mean frequency of LH pulses. Precise mechanisms underlying the pathophysiology of FHA are very complex and unclear. Numerous neuropeptides, neurotransmitters and neurosteroids play important roles in the physiological regulation of GnRH pulsatile secretion and there is evidence that different neuropeptides may be involved in the pathophysiology of FHA. Particular attention is paid to such substances as allopregnanolone, neuropeptide Y, corticotropin-releasing hormone, leptin, ghrelin and beta-endorphin. Some studies reveal significant changes in these mentioned substances in patients with FHA. There are also speculations about use some of these substances or their antagonists in the treatment of FHA.

Multifamily group treatment for veterans with traumatic brain injury: what is the value to participants?

PubMed

Straits-Troster, Kristy; Gierisch, Jennifer M; Strauss, Jennifer L; Dyck, Dennis G; Dixon, Lisa B; Norell, Diane; Perlick, Deborah A

2013-06-01

This study evaluated the feasibility, acceptability, and helpfulness of implementation of multifamily group treatment for traumatic brain injury (TBI) among veterans who sustained a TBI during the wars in Iraq and Afghanistan and their families or caregivers. Veterans and their family members who participated in an open clinical trial (August 2010-March 2011) of multifamily psychoeducation for TBI at two Veterans Affairs medical centers were invited to one of three focus groups. Participants were asked about problems experienced before and during the intervention, aspects of treatment that were helpful, and improvements that would facilitate effective implementation of multifamily group treatment for TBI. Postintervention focus group transcripts were analyzed by utilizing qualitative content analysis. Participants included eight veterans with TBI and eight family members. Five themes emerged: exploring common struggles and reducing isolation, building skills to cope with TBI and related problems, restoring relationships through communication and understanding, increasing understanding of the interconnection between TBI and posttraumatic stress disorder, and improving the multifamily group experience and increasing treatment engagement of veterans and families. Veterans and family members found multifamily group treatment for TBI highly acceptable and offered recommendations to improve and increase access to the program. The results supported the feasibility and acceptability of multifamily group treatment for TBI. Specific recommendations to improve this psychoeducational intervention and its implementation are offered.

Synthesis, characterization and cell behavior of fluoridated hydroxyapatite

NASA Astrophysics Data System (ADS)

Qu, Haibo

Fluorine-containing hydroxyapatite (Ca5(PO4) 3(OH)1-xFx FHA), where F- partially replaces OH- in hydroxyapatite (HA), is recognized as a possible biomaterial for bone and tooth implants and gaining attention in the last several years as a possible alternative to HA. In this study, FHA powders were synthesized through a pH-cycling method. It was discovered that fluorine incorporation increased with the fluorine content in the initial solution and the number of pH cycles employed. A relatively low fluorine incorporation efficiency, ˜60%, was attained for most of the FHA samples. The short time of stay at each pH cycle and the limited number of cycles used are believed to be the main reasons of the low fluorine incorporation into the apatite structure. It was also revealed that the FHA particles produced by the pH-cycling method were inhomogeneous. They were a mixture of hydroxyapatite and F-rich apatite (or FA) particles. The mechanisms of incorporation of fluorine ions into hydroxyapatite by a pH cyclicing method were studied using TEM, XRD and fluorine measurement. Instead of forming laminated structures as reported by other research groups, a mixture of nano-sized F-rich apatite (FHA) and hydroxyapatite (HA) particles were obtained using the pH-cyclicing method. After calcination, these FHA particles were homogenized and became single phased FHA. The effect of fluorine content, preparing method, and sintering temperature on both the bulk density and biaxial flexural strength of sintered FHA was studied. Both uniaxially pressed un-milled (UPU) and cold isostatically pressed milled (IPM) FHA discs were sintered at temperatures between 1200˜400°C at an interval of 100°C. It was found that the fluorine content had a significant impact on the sintering behavior, densification, and mechanical properties of FHA discs. A close correlation between the sintered density and biaxial flexural strength of the specimens was revealed, where the biaxial flexural strength increased exponentially with the sintered density. FHA discs with various fluorine contents have been used to investigate the effect of fluorine content on osteoblastic cell behaviors. Rat osteosarcoma (ROS 17/28) cells were cultured on FHA discs for appropriate times. The osteoblastic cell behaviors were examined in terms of cell attachment, proliferation, morphology and differentiation. The fluorine content in FHA strongly affected the cell activities. More cell attachment and proliferation were observed on the fluorine-containing FHA than pure HA. Fluorine content also affected the differentiation behaviors of osteoblastic cells. Cells on fluorine-containing FHA had higher alkaline phosphatase (ALP) activity than pure HA in 2 weeks. The morphology of the cells showed that it took less time for cells to cover the surface of fluorine-containing samples than that of pure HA. These results suggested that fluorine ions had a significant impact on osteoblastic cell behaviors.

Energy-Efficiency Retrofits in Small-Scale Multifamily Rental Housing: A Business Model

NASA Astrophysics Data System (ADS)

DeChambeau, Brian

The goal of this thesis to develop a real estate investment model that creates a financial incentive for property owners to perform energy efficiency retrofits in small multifamily rental housing in southern New England. The medium for this argument is a business plan that is backed by a review of the literature and input from industry experts. In addition to industry expertise, the research covers four main areas: the context of green building, efficient building technologies, precedent programs, and the Providence, RI real estate market for the business plan. The thesis concludes that the model proposed can improve the profitability of real estate investment in small multifamily rental properties, though the extent to which this is possible depends partially on utility-run incentive programs and the capital available to invest in retrofit measures.

Using research and education to implement practical bed bug control programs in multifamily housing.

PubMed

Bennett, Gary W; Gondhalekar, Ameya D; Wang, Changlu; Buczkowski, Grzegorz; Gibb, Timothy J

2016-01-01

Multifamily housing facilities serving low-income populations have been at the forefront of bed bug outbreaks. Research conducted in the past 8 years has consistently proven that integrated pest management (IPM) is the best approach for successful suppression of bed bug infestations. Bed bug IPM in multifamily settings is especially dependent upon a collaborative community or building-wide effort involving residents, building staff and pest control technicians. Other components of a bed bug IPM program include regular monitoring to detect early-stage bed bug infestations and combined use of non-chemical and chemical interventions. Lastly, to reduce reinfestation rates and costs associated with bed bug control, it is critical to continue periodic monitoring and implement preventive control measures even after successful elimination of bed bugs has been achieved. © 2015 Society of Chemical Industry.

Application of fluoridated hydroxyapatite thin film coatings using KrF pulsed laser deposition.

PubMed

Hashimoto, Yoshiya; Ueda, Mamoru; Kohiga, Yu; Imura, Kazuki; Hontsu, Shigeki

2018-06-08

Fluoridated hydroxyapatite (FHA) was investigated for application as an implant coating for titanium bone substitute materials in dental implants. A KrF pulsed excimer deposition technique was used for film preparation on a titanium plate. The compacts were ablated by laser irradiation at an energy density of 1 J/cm 2 on an area 1×1 mm 2 with the substrate at room temparature. Energydispersive spectrometric analysis of the FHA film revealed peaks of fluorine in addition to calcium and phosphorus. X-ray diffraction revealed the presence of crystalline FHA on the FHA film after a 10 h post annealing treatment at 450°C. The FHA film coating exhibited significant dissolution resistance to sodium phosphate buffer for up to 21 days, and favorable cell attachment of human mesenchymal stem cells compared with HA film. The results of this study suggest that FHA coatings are suitable for real-world implantation applications.

[Functional hypothalamic amenorrhea].

PubMed

Stárka, Luboslav; Dušková, Michaela

2015-10-01

Functional hypothalamic amenorrhea (FHA) besides pregnancy and syndrome of polycystic ovary is one of the most common causes of secondary amenorrhea. FHA results from the aberrations in pulsatile gonadotropin-releasing hormone (GnRH) secretion, which in turn causes impairment of the gonadotropins (follicle-stimulating hormone and luteinizing hormone). FHA is a form of the defence of organism in situations where life functions are more important than reproductive function. FHA is reversible; it can be normalized after ceasing the stress situation. There are three types of FHA: weight loss related, stress-related, and exercise-related amenorrhea. The final consequences are complex hormonal changes manifested by profound hypoestrogenism. Additionally, these patients present mild hypercortisolemia, low serum insulin levels, low insulin-like growth factor 1 (IGF-1) and low total triiodothyronine. Women health in this disorder is disturbed in several aspects including the skeletal system, cardiovascular system, and mental problems. Patients manifest a decrease in bone mass density, which is related to an increase in fracture risk. Therefore, osteopenia and osteoporosis are the main long-term complications of FHA. Cardiovascular complications include endothelial dysfunction and abnormal changes in the lipid profile. FHA patients present significantly higher depression and anxiety and also sexual problems compared to healthy subjects.

Functional hypothalamic amenorrhea is associated with elevated ghrelin and disordered eating.

PubMed

Schneider, Lisa F; Warren, Michelle P

2006-12-01

To determine whether ghrelin, an orexigen released by the stomach, is elevated in women with hypothalamic amenorrhea who are of normal weight and whether this is associated with abnormal eating behaviors. Controlled clinical study. Healthy volunteers in an academic research environment. Twenty-seven women with functional hypothalamic amenorrhea (FHA) and 42 normally menstruating women. None. Ghrelin and eating behavior. Ghrelin was significantly elevated in FHA (648.4 +/- 92.0 pg/mL vs. controls 596.7 +/- 79.0 pg/mL), while leptin, although lower, was not significantly so (FHA 5.4 +/- 2.8 ng/mL vs. controls 6.4 +/- 3 ng/mL). Eating Attitudes Test (EAT) scores were also significantly elevated in FHA (15.3 +/- 10.6 vs. controls 10.3 +/- 8.4), particularly on the subscale that measured bulimic behaviors. However, FHA patients consumed significantly more kilocalories (1,930 kcal/day vs. 1,588 kcal/day). High ghrelin in women with FHA may be linked to abnormal dietary behaviors, as reflected in high EAT scores yet characterized by normal caloric intake. Ghrelin may act as a restraining metabolic signal preventing a return to cyclicity in women with both disordered eating and FHA, prolonging amenorrhea when leptin has returned to normal.

Sol-gel derived fluor-hydroxyapatite biocoatings on zirconia substrate.

PubMed

Kim, Hae-Won; Kong, Young-Min; Bae, Chang-Jun; Noh, Yoon-Jung; Kim, Hyoun-Ee

2004-07-01

Fluor-hydroxyapatite (FHA) film was coated on a zirconia (ZrO(2)) substrate by a sol-gel method. An appropriate amount of F ions was incorporated into the hydroxyapatite (HA) during the preparation of the sols. The apatite phase began to crystallize after heat treatment at 400 degrees C, and increased in intensity above 500 degrees C. No decomposition was detected by X-ray diffraction analyses up to 800 degrees C, which illustrates the high thermal stability of the FHA films. The films showed a uniform and dense morphology with a thickness of approximately 1 microm after a precisely controlled heat treatment process. These FHA films adhered firmly to the zirconia substrate, representing notable adhesion strengths of approximately 70 MPa after heat treatment above 500 degrees C. The dissolution rate of the FHA coating layer varied according to the heat treatment temperature, which was closely related to the film crystallinity. The dissolution rate of the FHA film was lower than that of the HA film, suggesting the possibility of a functional gradient coating of HA and FHA. The MG63 cells seeded onto the FHA films proliferated in a similar manner to those seeded onto pure HA ceramic and a plastic control.

A Novel Non-canonical Forkhead-associated (FHA) Domain-binding Interface Mediates the Interaction between Rad53 and Dbf4 Proteins*

PubMed Central

Matthews, Lindsay A.; Selvaratnam, Rajeevan; Jones, Darryl R.; Akimoto, Madoka; McConkey, Brendan J.; Melacini, Giuseppe; Duncker, Bernard P.; Guarné, Alba

2014-01-01

Forkhead-associated (FHA) and BRCA1 C-terminal (BRCT) domains are overrepresented in DNA damage and replication stress response proteins. They function primarily as phosphoepitope recognition modules but can also mediate non-canonical interactions. The latter are rare, and only a few have been studied at a molecular level. We have identified a crucial non-canonical interaction between the N-terminal FHA1 domain of the checkpoint effector kinase Rad53 and the BRCT domain of the regulatory subunit of the Dbf4-dependent kinase that is critical to suppress late origin firing and to stabilize stalled forks during replication stress. The Rad53-Dbf4 interaction is phosphorylation-independent and involves a novel non-canonical interface on the FHA1 domain. Mutations within this surface result in hypersensitivity to genotoxic stress. Importantly, this surface is not conserved in the FHA2 domain of Rad53, suggesting that the FHA domains of Rad53 gain specificity by engaging additional interaction interfaces beyond their phosphoepitope-binding site. In general, our results point to FHA domains functioning as complex logic gates rather than mere phosphoepitope-targeting modules. PMID:24285546

77 FR 26304 - Federal Housing Administration (FHA) Healthcare Facility Documents: Proposed Revisions and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-03

...Consistent with the Paperwork Reduction Act of 1995 (PRA), HUD is publishing for public comment a comprehensive set of closing and other documents used in connection with transactions involving healthcare facilities (excluding hospitals) that are insured pursuant to section 232 of the National Housing Act (Section 232). In addition to meeting PRA requirements, this notice seeks public comment for the purpose of enlisting input from the lending industry and other interested parties in the development, updating, and adoption of a set of instruments (collectively, healthcare facility documents) that offer the requisite protection to all parties in these FHA-insured mortgage transactions, consistent with modern real estate and mortgage lending laws and practices. The healthcare facility documents, which are the subject of this notice, can be viewed on HUD's Web site: www.hud.gov/232forms. HUD is also publishing today a proposed rule that will submit for public comment certain revisions to FHA's Section 232 regulations for the purpose of ensuring consistency between the program regulations and the revised healthcare facility documents.

FHA Refinance Program Termination Act

THOMAS, 112th Congress

Rep. Dold, Robert J. [R-IL-10

2011-02-28

Senate - 03/14/2011 Received in the Senate and Read twice and referred to the Committee on Banking, Housing, and Urban Affairs. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

24 CFR 200.949 - Building product standards and certification program for exterior insulated steel door systems.

Code of Federal Regulations, 2010 CFR

2010-04-01

... INTRODUCTION TO FHA PROGRAMS Minimum Property Standards § 200.949 Building product standards and certification... product, the administrator's certification of compliance with the applicable standards is required to be... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Building product standards and...

24 CFR 200.947 - Building product standards and certification program for polystyrene foam insulation board.

Code of Federal Regulations, 2010 CFR

2010-04-01

... INTRODUCTION TO FHA PROGRAMS Minimum Property Standards § 200.947 Building product standards and certification... product, the administrator's certification of compliance with the applicable standards and the type of... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Building product standards and...

24 CFR 200.949 - Building product standards and certification program for exterior insulated steel door systems.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Mass Applications; (ii) ISDSI-100-90—Door Size Dimensional Standard and Assembly Tolerances for... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Building product standards and... INTRODUCTION TO FHA PROGRAMS Minimum Property Standards § 200.949 Building product standards and certification...

Decreased plasma concentrations of brain-derived neurotrophic factor (BDNF) in patients with functional hypothalamic amenorrhea.

PubMed

Podfigurna-Stopa, Agnieszka; Casarosa, Elena; Luisi, Michele; Czyzyk, Adam; Meczekalski, Blazej; Genazzani, Andrea Riccardo

2013-09-01

Functional hypothalamic amenorrhea (FHA) is a non organic, secondary amenorrhea related to gonadotropin-releasing hormone pulsatile secretion impairment. Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family of survival-promoting molecules, plays an important role in the growth, development, maintenance and function of several neuronal systems. The aim of the study was the evaluation of plasma BDNF concentrations in patients with the diagnosis of FHA. We studied 85 subjects diagnosed with FHA who were compared with 10 healthy, eumenorrheic controls with normal body mass index. Plasma BDNF and serum luteinizing hormone, follicle-stimulating hormone and estradiol (E2) concentrations were measured by immunoenzymatic method (enzyme-linked immunosorbent assay). Significantly lower concentration of plasma BDNF was found in FHA patients (196.31 ± 35.26 pg/ml) in comparison to healthy controls (407.20 ± 25.71 pg/ml; p < 0.0001). In the control group, there was a strong positive correlation between plasma BDNF and serum E2 concentrations (r = 0.92, p = 0.0001) but in FHA group it was not found. Role of BDNF in FHA is not yet fully understood. There could be found studies concerning plasma BDNF concentrations in humans and animals in the literature. However, our study is one of the first projects which describes decreased plasma BDNF concentration in patients with diagnosed FHA. Therefore, further studies on BDNF in FHA should clarify the role of this peptide.

24 CFR 266.520 - Program monitoring and compliance.

Code of Federal Regulations, 2010 CFR

2010-04-01

... AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and Servicing § 266.520 Program monitoring and compliance. HUD will monitor the...

24 CFR 266.520 - Program monitoring and compliance.

Code of Federal Regulations, 2012 CFR

2012-04-01

... AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and Servicing § 266.520 Program monitoring and compliance. HUD will monitor the...

24 CFR 266.520 - Program monitoring and compliance.

Code of Federal Regulations, 2011 CFR

2011-04-01

... AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and Servicing § 266.520 Program monitoring and compliance. HUD will monitor the...

24 CFR 266.520 - Program monitoring and compliance.

Code of Federal Regulations, 2013 CFR

2013-04-01

... AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and Servicing § 266.520 Program monitoring and compliance. HUD will monitor the...

24 CFR 266.520 - Program monitoring and compliance.

Code of Federal Regulations, 2014 CFR

2014-04-01

... AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and Servicing § 266.520 Program monitoring and compliance. HUD will monitor the...

76 FR 46833 - Notice of Proposed Information Collection: Comment Request; Application for FHA Insured Mortgages

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-03

... Insurance Division, Office of Single Family Program Development Division, Department of Housing and Urban.... This Notice also lists the following information: Title of Proposal: Requirements for Single Family... not include [[Page 46834

76 FR 59715 - Notice of Submission of Proposed Information Collection to OMB Energy Innovation Fund-Multifamily...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-27

...The proposed information collection requirement described below has been submitted to the Office of Management and Budget (OMB) for review, as required by the Paperwork Reduction Act. The Department is soliciting public comments on the subject proposal. This information is collected from applicants for a new pilot program seeking innovative proposals for increasing the energy efficiency of Multifamily Housing.

78 FR 341 - Proposed Information Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-03

..., Parkersburg, WV 26106-1328, (304) 480-8150. SUPPLEMENTARY INFORMATION: Form Numbers and Title: PD F 5354--FHA Transaction Request; PD F 5366--FHA New Account Request; PD F 5367--FHA Debenture Transfer Request. OMB Number: 1535-0102. Abstract: The information is used to (1) Establish a book-entry account; (2) change...

75 FR 22418 - FHA TOTAL Mortgage Scorecard

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-28

... and requirements to provide reports and loan samples at FHA's request, and appeals in writing for loss... requirements to provide reports and loan samples at FHA's request, and appeals in writing for loss of privilege... INFORMATION CONTACT: Leroy McKinney, Jr., Reports Management Officer, QDAM, Department of Housing and Urban...

77 FR 11798 - Federal Housing Administration (FHA) Risk Management Initiatives: Revised Seller Concessions...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-28

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT 24 CFR Chapter II [Docket No. FR-5572-C-02] Federal Housing Administration (FHA) Risk Management Initiatives: Revised Seller Concessions; Addresses for the... Administration (FHA) Risk Management Initiatives: Revised Seller Concessions). 1. Submission of Comments by Mail...

Coatings of needle/stripe-like fluoridated hydroxyapatite on H2O2-treated carbon/carbon composites prepared by induction heating and hydrothermal methods

NASA Astrophysics Data System (ADS)

Xiong, Xin-Bo; Huang, Jian-Feng; Zeng, Xie-Rong; Liang, Ping; Zou, Ji-Zhao

2012-06-01

A hydroxyapatite (HA) coating was achieved on H2O2-treated carbon/carbon (C/C) composite through hydrothermally treating and induction heating deposited CaHPO4 coating in an ammonia solution under ultrasonic water bath. Then, this HA coating was placed in a NH4F solution and hydrothermally treated again to fabricate fluorinated hydroxyapatite (FHA) coatings for 24 h at 353, 373, 393 and 413 K, respectively. The structure, morphology and chemical composition of the HA and FHA coatings were characterized by SEM, XRD, EDS and FTIR, and the adhesiveness and chemical stability of these FHA coatings were examined by a scratch test and an immersion test, respectively. The results showed that the as-prepared FHA coatings contained needle-like or stripe-like crystals, different from those of the HA coating. As the fluoridation temperature rose, the adhesiveness of the FHA coating first increased from 34.8 to 40.9 N at a temperature between 353 and 393 K, and then decreased to 24.2 N at 413 K, while the dissolution rate of the FHA coating decreased steadily. The reasons for the property variation of the FHA coatings were proposed by analyzing the morphology, composition and structure of the coatings.

Functional hypothalamic amenorrhea and its psychological correlates: a controlled comparison.

PubMed

Pentz, Ivana; Nakić Radoš, Sandra

2017-04-01

The goal of the study was to examine differences between adolescents and young women with functional hypothalamic amenorrhea (FHA) and control groups in personality traits, eating attitudes and behaviours, and perception of parental behaviour. The FHA is stress-induced anovulation, both related to metabolic challenges, such as excessive exercise and malnutrition, and psychogenic challenges, such as perfectionism and poor coping strategies. Three groups of adolescents and young women participated in the study: the FHA group (N = 25), the organic anovulation group (N = 21) and the eumenorrheic group with regular menstrual cycle (N = 20). Questionnaires on multidimensional perfectionism, self-control methods, eating attitudes and behaviours and perception of parental behaviour were administered. A clinical interview (SCID) was conducted with each participant. The FHA group had higher levels of perfectionism traits, i.e. higher levels of concerns over mistakes and personal standards, compared to control groups. The FHA group did not engage in disordered eating behaviours more often in comparison with control groups, but reported more prevalent history of anorexia nervosa. The FHA group did not differ from controls in perception of parental rejection, emotional warmth or overprotection. The findings suggest that FHA can be characterised by the subtle psychological differences in personality traits, so the patients need to be diagnosed carefully.

Functional hypothalamic amenorrhea and its influence on women's health.

PubMed

Meczekalski, B; Katulski, K; Czyzyk, A; Podfigurna-Stopa, A; Maciejewska-Jeske, M

2014-11-01

Functional hypothalamic amenorrhea (FHA) is one of the most common causes of secondary amenorrhea. There are three types of FHA: weight loss-related, stress-related, and exercise-related amenorrhea. FHA results from the aberrations in pulsatile gonadotropin-releasing hormone (GnRH) secretion, which in turn causes impairment of the gonadotropins (follicle-stimulating hormone and luteinizing hormone). The final consequences are complex hormonal changes manifested by profound hypoestrogenism. Additionally, these patients present mild hypercortisolemia, low serum insulin levels, low insulin-like growth factor 1 (IGF-1) and low total triiodothyronine. The aim of this work is to review the available data concerning the effects of FHA on different aspects of women's health. Functional hypothalamic amenorrhea is related to profound impairment of reproductive functions including anovulation and infertility. Women's health in this disorder is disturbed in several aspects including the skeletal system, cardiovascular system, and mental problems. Patients manifest a decrease in bone mass density, which is related to an increase in fracture risk. Therefore, osteopenia and osteoporosis are the main long-term complications of FHA. Cardiovascular complications include endothelial dysfunction and abnormal changes in the lipid profile. FHA patients present significantly higher depression and anxiety and also sexual problems compared to healthy subjects. FHA patients should be carefully diagnosed and properly managed to prevent both short- and long-term medical consequences.

24 CFR 200.191 - Placement of 203(k) consultant.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Placement of 203(k) consultant. 200... Participation in FHA Programs Section 203(k) Rehabilitation Loan Consultants § 200.191 Placement of 203(k... certify that it has read and fully understands the requirements of the HUD handbook on the 203(k) Program...

24 CFR 200.191 - Placement of 203(k) consultant.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Placement of 203(k) consultant. 200... Participation in FHA Programs Section 203(k) Rehabilitation Loan Consultants § 200.191 Placement of 203(k... certify that it has read and fully understands the requirements of the HUD handbook on the 203(k) Program...

24 CFR 200.191 - Placement of 203(k) consultant.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Placement of 203(k) consultant. 200... Participation in FHA Programs Section 203(k) Rehabilitation Loan Consultants § 200.191 Placement of 203(k... certify that it has read and fully understands the requirements of the HUD handbook on the 203(k) Program...

24 CFR 200.191 - Placement of 203(k) consultant.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Placement of 203(k) consultant. 200... Participation in FHA Programs Section 203(k) Rehabilitation Loan Consultants § 200.191 Placement of 203(k... certify that it has read and fully understands the requirements of the HUD handbook on the 203(k) Program...

24 CFR 200.191 - Placement of 203(k) consultant.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Placement of 203(k) consultant. 200... Participation in FHA Programs Section 203(k) Rehabilitation Loan Consultants § 200.191 Placement of 203(k... certify that it has read and fully understands the requirements of the HUD handbook on the 203(k) Program...

78 FR 25184 - Federal Housing Administration (FHA): Section 232 Healthcare Facility Insurance Program...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-30

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT 24 CFR Parts 5, 200, 207, and 232 [Docket No. FR-5465... Residential Care Facilities, Office of Healthcare Programs, Office of Housing, Department of Housing and Urban Development, 451 7th Street SW., Room 6264, Washington, DC 20410-8000; telephone number 202-708- 0599 (this is...

Deposition of nanostructured fluorine-doped hydroxyapatite-polycaprolactone duplex coating to enhance the mechanical properties and corrosion resistance of Mg alloy for biomedical applications.

PubMed

Bakhsheshi-Rad, H R; Hamzah, E; Kasiri-Asgarani, M; Jabbarzare, S; Iqbal, N; Abdul Kadir, M R

2016-03-01

The present study addressed the synthesis of a bi-layered nanostructured fluorine-doped hydroxyapatite (nFHA)/polycaprolactone (PCL) coating on Mg-2Zn-3Ce alloy via a combination of electrodeposition (ED) and dip-coating methods. The nFHA/PCL composite coating is composed of a thick (70-80 μm) and porous layer of PCL that uniformly covered the thin nFHA film (8-10 μm) with nanoneedle-like microstructure and crystallite size of around 70-90 nm. Electrochemical measurements showed that the nFHA/PCL composite coating presented a high corrosion resistance (R(p)=2.9×10(3) kΩ cm(2)) and provided sufficient protection for a Mg substrate against galvanic corrosion. The mechanical integrity of the nFHA/PCL composite coatings immersed in SBF for 10 days showed higher compressive strength (34% higher) compared with the uncoated samples, indicating that composite coatings can delay the loss of compressive strength of the Mg alloy. The nFHA/PCL coating indicted better bonding strength (6.9 MPa) compared to PCL coating (2.2 MPa). Immersion tests showed that nFHA/PCL composite-coated alloy experienced much milder corrosion attack and more nucleation sites for apatite compared with the PCL coated and uncoated samples. The bi-layered nFHA/PCL coating can be a good alternative method for the control of corrosion degradation of biodegradable Mg alloy for implant applications. Copyright © 2015 Elsevier B.V. All rights reserved.

24 CFR 266.405 - Title.

Code of Federal Regulations, 2010 CFR

2010-04-01

... MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Mortgage and Closing...

24 CFR 200.73 - Property development.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Property development. 200.73 Section 200.73 Housing and Urban Development Regulations Relating to Housing and Urban Development... URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Requirements for Application, Commitment, and...

76 FR 23615 - Notice of Submission of Proposed Information Collection to OMB; Application for HUD/FHA Insured...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-27

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5480-N-38] Notice of Submission of Proposed Information Collection to OMB; Application for HUD/FHA Insured Mortgage ``Hope for Homeowners... Proposal: Application for HUD/FHA Insured Mortgage ``Hope for Homeowners''. OMB Approval Number: 2502-0579...

78 FR 8551 - Federal Housing Administration (FHA) Risk Management Initiatives: Changes to Maximum Loan-to...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-06

... Administration (FHA) Risk Management Initiatives: Changes to Maximum Loan-to-Value Financing Solicitation of... performance of the portfolio, and adjust its standards to effectively manage financial risk. As a result, FHA has been continually evaluating its portfolio to identify and respond to risks in ways that benefit...

Psychological correlates of functional hypothalamic amenorrhea.

PubMed

Marcus, M D; Loucks, T L; Berga, S L

2001-08-01

To determine whether mood, attitudes, or symptoms of disordered eating discriminated women with functional hypothalamic amenorrhea (FHA) from those with organic causes of amenorrhea and eumenorrhea. Cross-sectional comparison of women with FHA, women with organic amenorrhea, and eumenorrheic control women. Clinical research center in an academic medical institution. Seventy-seven women > or =18 years old with time since menarche > or =5 and < or =25 years were recruited by advertisement. Ovulation was confirmed in eumenorrheic control women. Causes of anovulation were carefully documented in amenorrheic participants and LH pulse profiles were obtained to document the diagnosis of FHA. All participants were interviewed and completed questionnaires. Self-report measures of dysfunctional attitudes, coping styles, and symptoms of depression and eating disorders. Women with FHA reported more depressive symptoms and dysfunctional attitudes than did eumenorrheic women, but not significantly more than women with organic amenorrhea. However, women with FHA reported significantly more symptoms of disordered eating than did either anovulatory or ovulatory women. The findings are consistent with the hypothesis that FHA is precipitated by a combination of psychosocial stressors and metabolic challenge.

Multifamily psychoeducation for first-episode psychosis: a cost-effectiveness analysis.

PubMed

Breitborde, Nicholas J K; Woods, Scott W; Srihari, Vinod H

2009-11-01

Family psychoeducation is considered part of optimal treatment for first-episode psychosis, but concerns about the cost of this intervention have limited its availability. Although evidence suggests that family psychoeducation is cost-effective, many cost-effectiveness analyses have suffered from limitations that reduce their utility in guiding decisions to incorporate this intervention within existing clinical services. These include not presenting results in present-day dollars and not examining whether the intervention would remain cost-effective in situations where the clinical benefits achieved were smaller than those reported in past studies. Thus the goal of this study was to investigate the cost of providing a specific psychoeducation program-multifamily group psychoeducation-to individuals with first-episode psychosis and their families. Statistical simulation was used to estimate the cost and burden of illness associated with usual treatment versus usual treatment plus multifamily group psychoeducation. In addition, the simulation model was rerun to test whether multifamily psychoeducation would remain cost-effective in situations where the clinical benefits achieved were smaller than those reported in past studies. When provided for two years, multifamily group psychoeducation ranged from a cost-effective to a cost-saving intervention, depending on the clinical benefits achieved by staff delivering the intervention. When provided for longer durations (five, ten, or 20 years), multifamily psychoeducation was a cost-saving intervention even in scenarios where the clinical benefits of the intervention were reduced by 90%. The results suggest that multifamily group psychoeducation may not only be a cost-effective intervention for first-episode psychosis but may often be a cost-saving intervention.

Neuroendocrine recovery initiated by cognitive behavioral therapy in women with functional hypothalamic amenorrhea: a randomized, controlled trial.

PubMed

Michopoulos, Vasiliki; Mancini, Fulvia; Loucks, Tammy L; Berga, Sarah L

2013-06-01

To determine whether cognitive behavior therapy (CBT), which we had shown in a previous study to restore ovarian function in women with functional hypothalamic amenorrhea (FHA), could also ameliorate hypercortisolemia and improve other neuroendocrine and metabolic concomitants of in FHA. Randomized controlled trial. Clinical research center at an academic medical university. Seventeen women with FHA were randomized either to CBT or observation. CBT versus observation. Circulatory concentrations of cortisol, leptin, thyroid-stimulating hormone (TSH), total and free thyronine (T(3)), and total and free thyroxine (T(4)) before and immediately after completion of CBT or observation. (Each woman served as her own control.) Cognitive behavior therapy but not observation reduced cortisol levels in women with FHA. There were no changes in cortisol, leptin, TSH, T(3), or T(4) levels in women randomized to observation. Women treated with CBT showed increased levels of leptin and TSH, but their levels of T(3) and T(4) remained unchanged. In women with FHA, CBT ameliorated hypercortisolism and improved the neuroendocrine and metabolic concomitants of FHA while observation did not. We conclude that a cognitive, nonpharmacologic approach aimed at alleviating problematic attitudes not only can restore ovarian activity but also improve neuroendocrine and metabolic function in women with FHA. NCT01674426. Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

Poly(ε-caprolactone)/nano fluoridated hydroxyapatite scaffolds for bone tissue engineering: in vitro degradation and biocompatibility study.

PubMed

Johari, N; Fathi, M H; Golozar, M A; Erfani, E; Samadikuchaksaraei, A

2012-03-01

In this study, biodegradation and biocompatibility of novel poly(ε-caparolactone)/nano fluoridated hydroxyapatite (PCL-FHA) scaffolds were investigated. The FHA nanopowders were prepared via mechanical alloying method and had a chemical composition of Ca(10)(PO(4))(6)OH(2-x )F(x) (where x values were selected equal to 0.5 and 2.0). In order to fabricate PCL-FHA scaffolds, 10, 20, 30 and 40 wt% of the FHA were added to the PCL. The PCL-FHA scaffolds were produced by the solvent casting/particulate leaching using sodium chloride particles (with diameters of 300-500 μm) as the porogen. The phase structure, microstructure and morphology of the scaffolds were evaluated using X-ray diffraction, Fourier transform infrared spectroscopy and scanning electron microscopy techniques. Porosity of the scaffolds was measured using the Archimedes' Principle. In vitro degradation of PCL-FHA scaffolds was studied by incubating the samples in phosphate buffered saline at 37°C and pH 7.4 for 30 days. Moreover, biocompatibility was evaluated by MTT assay after seeding and culture of osteoblast-like cells on the scaffolds. Results showed that the osteoblast-like cells attached to and proliferated on PCL-FHA and increasing the porosity of the scaffolds increased the cell viability. Also, degradation rate of scaffolds were increased with increasing the fluorine content in scaffolds composition.

7 CFR 1956.100 - OMB control number.

Code of Federal Regulations, 2014 CFR

2014-01-01

...) PROGRAM REGULATIONS (CONTINUED) DEBT SETTLEMENT Debt Settlement-Farm Loan Programs and Multi-Family..., with an average of 20 minutes per response including time for reviewing instructions, searching...

7 CFR 1956.100 - OMB control number.

Code of Federal Regulations, 2013 CFR

2013-01-01

...) PROGRAM REGULATIONS (CONTINUED) DEBT SETTLEMENT Debt Settlement-Farm Loan Programs and Multi-Family..., with an average of 20 minutes per response including time for reviewing instructions, searching...

7 CFR 1956.100 - OMB control number.

Code of Federal Regulations, 2011 CFR

2011-01-01

...) PROGRAM REGULATIONS (CONTINUED) DEBT SETTLEMENT Debt Settlement-Farm Loan Programs and Multi-Family..., with an average of 20 minutes per response including time for reviewing instructions, searching...

7 CFR 1956.100 - OMB control number.

Code of Federal Regulations, 2012 CFR

2012-01-01

...) PROGRAM REGULATIONS (CONTINUED) DEBT SETTLEMENT Debt Settlement-Farm Loan Programs and Multi-Family..., with an average of 20 minutes per response including time for reviewing instructions, searching...

24 CFR 200.101 - Mortgagor lien certificate.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Mortgagor lien certificate. 200.101 Section 200.101 Housing and Urban Development Regulations Relating to Housing and Urban Development... URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Requirements for Application, Commitment, and...

24 CFR 200.1001 - Cross-reference.

Code of Federal Regulations, 2010 CFR

2010-04-01

... URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Social Security Numbers and Employer Identification Numbers; Assistance Applicants and Participants § 200.1001 Cross-reference. The provisions in subpart B of part 5 of this title apply to Social Security Numbers and Employer Identification Numbers for...

Long-lived respiratory immune response to filamentous hemagglutinin following Bordetella pertussis infection.

PubMed Central

Amsbaugh, D F; Li, Z M; Shahin, R D

1993-01-01

Systemic and mucosal B-cell-mediated immune responses to purified filamentous hemagglutinin (FHA) in mice were analyzed at different times following a single respiratory infection with Bordetella pertussis. Serum immunoglobulin G (IgG) anti-FHA and respiratory IgG and IgA anti-FHA antibodies were first detected at 3 weeks postinfection, reached high levels by 8 weeks postinfection, and remained at high levels 12 to 32 weeks postinfection. FHA-specific B lymphocytes isolated from the spleens or lungs of uninfected control mice or mice convalescing from B. pertussis respiratory infection were analyzed in limiting-dilution cultures. Analysis of culture supernatants for the production of antibodies to FHA revealed an increased frequency of FHA-specific B cells of both the IgG- and the IgA-secreting classes in the lungs and tracheas of aerosol-challenged mice; these levels remained high as late as 25 weeks postinfection, compared with those in uninfected controls. No corresponding increase in the frequency of FHA-specific B cells in the spleens of aerosol-infected mice was observed. This long-lasting response observed in cultured cells was radiation resistant, a result suggesting that this response was due to B cells already activated in vivo. Polymerase chain reaction analysis revealed low but detectable levels of B. pertussis chromosomal DNA in 75% of mice tested at 8 weeks postinfection and 37.5% of mice tested at 26 weeks postinfection, at which times high levels of anti-FHA antibody were detected. One explanation for these data may be that, in this animal model, a major adhesin of B. pertussis can persist and interact with components of the immune system to stimulate the production of specific antibody in the respiratory tract many weeks after a single B. pertussis infection. PMID:8454349

Low-energy density and high fiber intake are dietary concerns in female endurance athletes.

PubMed

Melin, A; Tornberg, Å B; Skouby, S; Møller, S S; Faber, J; Sundgot-Borgen, J; Sjödin, A

2016-09-01

Low or reduced energy availability (LEA) is linked to functional hypothalamic oligomenorrhea/amenorrhea (FHA), which is frequently reported in weight-sensitive sports. This makes LEA a major nutritional concern for female athletes. The aim of this study was to describe dietary characteristics of athletes with LEA and/or FHA. Endurance athletes (n = 45) were recruited from national teams and competitive clubs. Protocols included gynecological examination, body composition, eating disorder evaluation, and 7-day dietary intake and EA assessment. Athletes with disordered eating behavior/eating disorders (n = 11), menstrual dysfunction other than FHA (n = 5), and low dietary record validity (n = 4) were excluded. Remaining subjects (n = 25) were characterized by EA [optimal: ≥ 45 kcal (188 kJ)/kg fat-free mass (FFM)/day (n = 11), LEA: < 45 kcal (188 kJ)/kg FFM/day (n = 14)] and reproductive function [eumenorrhea (EUM; n = 10), FHA (n = 15)]. There was no difference in EA between FHA and EUM subjects. However, FHA and LEA subjects shared the same dietary characteristics of lower energy density (ED) [(P = 0.012; P = 0.020), respectively], and fat content [(P = 0.047; P = 0.027), respectively]. Furthermore, FHA subjects had a lower intake of carbohydrate-rich foods (P = 0.019), higher fiber content (P < 0.001), and drive for thinness score (P = 0.003). Conclusively, low ED together with high fiber content may constitute targets for dietary intervention in order to prevent and treat LEA and FHA in female athletes. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

24 CFR 200.620 - Requirements.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Requirements. 200.620 Section 200... Requirements. With respect to all FHA subsidized or unsubsidized programs in which the applicant hereafter... of these regulations), the applicant shall meet the following requirements or, if he contracts...

24 CFR 200.620 - Requirements.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Requirements. 200.620 Section 200... Requirements. With respect to all FHA subsidized or unsubsidized programs in which the applicant hereafter... of these regulations), the applicant shall meet the following requirements or, if he contracts...

77 FR 40310 - Federal Housing Administration (FHA) Section 232 Healthcare Mortgage Insurance Program: Partial...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-09

... would occur 3 to 7 years after origination, following 10 to 30 months of delinquency. The savings to HUD... requirements, unless the agency certifies that the rule will not have a significant economic impact on a... [[Page 40314

Characterization of the APLF FHA-XRCC1 phosphopeptide interaction and its structural and functional implications.

PubMed

Kim, Kyungmin; Pedersen, Lars C; Kirby, Thomas W; DeRose, Eugene F; London, Robert E

2017-12-01

Aprataxin and PNKP-like factor (APLF) is a DNA repair factor containing a forkhead-associated (FHA) domain that supports binding to the phosphorylated FHA domain binding motifs (FBMs) in XRCC1 and XRCC4. We have characterized the interaction of the APLF FHA domain with phosphorylated XRCC1 peptides using crystallographic, NMR, and fluorescence polarization studies. The FHA-FBM interactions exhibit significant pH dependence in the physiological range as a consequence of the atypically high pK values of the phosphoserine and phosphothreonine residues and the preference for a dianionic charge state of FHA-bound pThr. These high pK values are characteristic of the polyanionic peptides typically produced by CK2 phosphorylation. Binding affinity is greatly enhanced by residues flanking the crystallographically-defined recognition motif, apparently as a consequence of non-specific electrostatic interactions, supporting the role of XRCC1 in nuclear cotransport of APLF. The FHA domain-dependent interaction of XRCC1 with APLF joins repair scaffolds that support single-strand break repair and non-homologous end joining (NHEJ). It is suggested that for double-strand DNA breaks that have initially formed a complex with PARP1 and its binding partner XRCC1, this interaction acts as a backup attempt to intercept the more error-prone alternative NHEJ repair pathway by recruiting Ku and associated NHEJ factors. Published by Oxford University Press on behalf of Nucleic Acids Research 2017.

75 FR 23796 - Multifamily Housing Service Coordinator Program

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-04

... applicants and to determine how well grant funds meet stated program goals and how well the public was served... well grant funds meet stated program goals and how well the public was served. Frequency of Submission...

24 CFR 200.925c - Model codes.

Code of Federal Regulations, 2011 CFR

2011-04-01

... DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Minimum Property Standards § 200.925c Model codes. (a... Plumbing Code, 1993 Edition, and the BOCA National Mechanical Code, 1993 Edition, excluding Chapter I, Administration, for the Building, Plumbing and Mechanical Codes and the references to fire retardant treated wood...

24 CFR 200.925c - Model codes.

Code of Federal Regulations, 2010 CFR

2010-04-01

... DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Minimum Property Standards § 200.925c Model codes. (a... Plumbing Code, 1993 Edition, and the BOCA National Mechanical Code, 1993 Edition, excluding Chapter I, Administration, for the Building, Plumbing and Mechanical Codes and the references to fire retardant treated wood...

24 CFR 203.255 - Insurance of mortgage.

Code of Federal Regulations, 2011 CFR

2011-04-01

... prescribed by the Secretary, stating that the underwriter has personally reviewed the appraisal report and..., reports and loan samples that enable FHA to evaluate program operation; (3) Not use TOTAL to direct... algorithm in TOTAL; (5) Not provide feedback messages that conflict with the Equal Credit Opportunity Act...

Short-term estriol administration modulates hypothalamo-pituitary function in patients with functional hypothalamic amenorrhea (FHA).

PubMed

Genazzani, Alessandro D; Podfigurna-Stopa, Agnieszka; Czyzyk, Adam; Katulski, Krzysztof; Prati, Alessia; Despini, Giulia; Angioni, Stefano; Simoncini, Tommaso; Meczekalski, Blazej

2016-01-01

To evaluate the influence of short-term estriol administration (10 d) on the hypothalamus-pituitary function and gonadotropins secretion in patients affected by functional hypothalamic amenorrhea (FHA). Controlled clinical study on patients with FHA (n = 12) in a clinical research environment. Hormonal determinations and gonadotropin (luteinizing hormone [LH] and FSH) response to a gonadotropin-releasing hormone (GnRH) bolus (10 μg) at baseline condition and after 10 d of therapy with 2 mg/d of estriol per os. Measurements of plasma LH, FSH, prolactin, estradiol, androstenedione, 17α-hydroxyprogesterone, insulin, cortisol, thyroid-stimulating hormone, free triiodothyronine, and free thyroxine. After treatment, the FHA patients showed a statistically significant increase of both LH and FSH plasma levels and the significant increase of their responses to the GnRH bolus. Estriol short-term therapy modulates within 10 d of administration the neuroendocrine control of the hypothalamus-pituitary unit and induces the recovery of both gonadotropins synthesis and secretion in hypogonadotropic patients with FHA.

Neuroendocrine recovery initiated by cognitive behavioral therapy in women with functional hypothalamic amenorrhea: a randomized controlled trial

PubMed Central

Michopoulos, Vasiliki; Mancini, Fulvia; Loucks, Tammy L.; Berga, Sarah L.

2013-01-01

Objective To determine whether cognitive behavior therapy (CBT), which we previously showed restored ovarian function in women with functional hypothalamic amenorrhea (FHA), also ameliorated hypercortisolemia and improved other neuroendocrine and metabolic concomitants of in FHA. Design Randomized controlled trial. Intervention CBT vs. observation. Setting Clinical research center at an academic medical university. Patient(s) Seventeen women with FHA were randomized either to CBT or observation. Main Outcome Measure(s) Circulatory concentrations of cortisol, leptin, TSH, total and free thyronine (T3), and total and free thyroxine (T4) before and immediately after completion of CBT or observation. Each woman served as her own control. Results CBT but not observation reduced cortisol levels in women with FHA. There were no changes in cortisol, leptin, TSH, T3, or T4 levels in women randomized to observation. Women treated with CBT showed increased levels of leptin and TSH, while levels of T3 and T4 remained unchanged. Conclusions CBT ameliorated hypercortisolism and improved neuroendocrine and metabolic concomitants of FHA while observation did not. We conclude that a cognitive, nonpharmacological approach aimed at alleviating problematic attitudes not only restored ovarian activity but also improved neuroendocrine and metabolic function in women with FHA. PMID:23507474

Features of polycystic ovary syndrome (PCOS) in women with functional hypothalamic amenorrhea (FHA) may be reversible with recovery of menstrual function.

PubMed

Carmina, Enrico; Fruzzetti, Franca; Lobo, Roger A

2018-04-01

Since features of polycystic ovary syndrome (PCOS) have been found to be prevalent in women with functional hypothalamic amenorrhea (FHA), we wished to determine what happens to these features after recovery of menstrual function in FHA Design: Prospective cohort study. Twenty-eight women with FHA and 30 age-matched ovulatory controls were studied. Twenty-eight women with FHA and 30 age-matched ovulatory controls were studied. We measured serum estradiol, LH, FSH, testosterone, DHEAS, anti-Mullerian hormone (AMH), body mass index, and ovarian morphology on transvaginal ultrasound. At baseline, 12 of the 28 women (43%) had increased AMH (>4.7 ng/mL), and higher testosterone and larger ovaries compared to the other 16 women with normal AMH. One year after recovery of menstrual function, in the 12 women with increased AMH, serum AMH, testosterone and ovarian size decreased, while LH and estradiol increased. At one year, only one of the 12 women in the high AMH group developed clinical features of PCOS. In the majority of women with FHA who have PCOS-like features, these features may be due to the hypothalamic state and appear to be reversible. Few women may develop clinical PCOS after recovery.

New Whole-House Solutions Case Study: Zero Energy Ready Home Multifamily Project: Mutual Housing at Spring Lake

DOE Office of Scientific and Technical Information (OSTI.GOV)

D. Springer and A. German

2015-09-01

Building cost effective, high performance homes that provide superior comfort, health, and durability is the goal of the Department of Energy's (DOE's) Zero Energy Ready Homes (ZERH) program. This case study describes the development of a 62-unit multifamily community constructed by nonprofit developer Mutual Housing at the Spring Lake subdivision in Woodland, California. The Spring Lake project is expected to be the first ZERH-certified multifamily project nationwide. Building America team Alliance for Residential Building Innovation worked with Mutual Housing throughout the project. An objective of this project was to gain a highly visible foothold for residential buildings built to themore » DOE ZERH specification that can be used to encourage participation by other California builders.« less

76 FR 14420 - Notice of Submission of Proposed Information Collection to OMB; Emergency Comment Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-16

... Proposed Information Collection to OMB; Emergency Comment Request; Federal Housing Administration (FHA): Home Energy Retrofit Loan Pilot Program; Notice of Proposed Information Collection for Public Comment... Reduction Act. The Department is soliciting public comments on the subject proposal. DATES: Comments Due...

75 FR 70941 - Notice of Submission of Proposed Information Collection to OMB; Emergency Comment Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-19

... Proposed Information Collection to OMB; Emergency Comment Request; Federal Housing Administration (FHA): Home Energy Retrofit Loan Pilot Program; Notice of Proposed Information Collection for Public Comment... Reduction Act. The Department is soliciting public comments on the subject proposal. DATES: Comments Due...

75 FR 69697 - Notice of Submission of Proposed Information Collection to OMB; Emergency Comment Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-15

... Proposed Information Collection to OMB; Emergency Comment Request; Federal Housing Administration (FHA): Home Energy Retrofit Loan Pilot Program; Notice of Proposed Information Collection for Public Comment... Reduction Act. The Department is soliciting public comments on the subject proposal. DATES: Comments Due...

24 CFR 200.640 - Effect on other requirements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Effect on other requirements. 200... HOUSING AND URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Affirmative Fair Housing Marketing Regulations § 200.640 Effect on other requirements. The requirement for compliance with this part is in...

24 CFR 200.926b - Model codes.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Model codes. 200.926b Section 200... DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Minimum Property Standards § 200.926b Model codes. (a) Incorporation by reference. The following model code publications are incorporated by reference in accordance...

24 CFR 4001.401 - Notice of false information from mortgagor-procedure.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Notice of false information from... HOMEOWNERS PROGRAM Enforcement Mortgagor False Information § 4001.401 Notice of false information from... information via any means, including but not limited to false documentation, FHA shall inform the mortgagor...

24 CFR 200.192 - Removal of 203(k) consultant.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Removal of 203(k) consultant. 200.192 Section 200.192 Housing and Urban Development Regulations Relating to Housing and Urban... Participation in FHA Programs Section 203(k) Rehabilitation Loan Consultants § 200.192 Removal of 203(k...

24 CFR 200.192 - Removal of 203(k) consultant.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Removal of 203(k) consultant. 200.192 Section 200.192 Housing and Urban Development Regulations Relating to Housing and Urban... Participation in FHA Programs Section 203(k) Rehabilitation Loan Consultants § 200.192 Removal of 203(k...

24 CFR 200.192 - Removal of 203(k) consultant.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Removal of 203(k) consultant. 200.192 Section 200.192 Housing and Urban Development Regulations Relating to Housing and Urban... Participation in FHA Programs Section 203(k) Rehabilitation Loan Consultants § 200.192 Removal of 203(k...

24 CFR 200.192 - Removal of 203(k) consultant.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Removal of 203(k) consultant. 200.192 Section 200.192 Housing and Urban Development Regulations Relating to Housing and Urban... Participation in FHA Programs Section 203(k) Rehabilitation Loan Consultants § 200.192 Removal of 203(k...

24 CFR 200.192 - Removal of 203(k) consultant.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Removal of 203(k) consultant. 200.192 Section 200.192 Housing and Urban Development Regulations Relating to Housing and Urban... Participation in FHA Programs Section 203(k) Rehabilitation Loan Consultants § 200.192 Removal of 203(k...

24 CFR 200.600 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Purpose. 200.600 Section 200.600 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS...

24 CFR 200.605 - Authority.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Authority. 200.605 Section 200.605 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS...

24 CFR 200.635 - Compliance.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Compliance. 200.635 Section 200.635... GENERAL INTRODUCTION TO FHA PROGRAMS Affirmative Fair Housing Marketing Regulations § 200.635 Compliance... Department will enforce compliance through the procedures outlined in 24 CFR part 108. [37 FR 75, Jan. 5...

24 CFR 200.635 - Compliance.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Compliance. 200.635 Section 200.635... GENERAL INTRODUCTION TO FHA PROGRAMS Affirmative Fair Housing Marketing Regulations § 200.635 Compliance... Department will enforce compliance through the procedures outlined in 24 CFR part 108. [37 FR 75, Jan. 5...

7 CFR 1956.54 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... SERVICE, RURAL UTILITIES SERVICE, AND FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE (CONTINUED) PROGRAM REGULATIONS (CONTINUED) DEBT SETTLEMENT Debt Settlement-Farm Loan Programs and Multi-Family Housing § 1956.54... the purposes of servicing Farm Loan Programs loans, debt forgiveness is defined as a reduction or...

7 CFR 1956.54 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... SERVICE, RURAL UTILITIES SERVICE, AND FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE (CONTINUED) PROGRAM REGULATIONS (CONTINUED) DEBT SETTLEMENT Debt Settlement-Farm Loan Programs and Multi-Family Housing § 1956.54... the purposes of servicing Farm Loan Programs loans, debt forgiveness is defined as a reduction or...

Contribution of Bordetella Filamentous Hemagglutinin and Adenylate Cyclase Toxin to Suppression and Evasion of Interleukin-17-Mediated Inflammation

PubMed Central

Henderson, Michael W.; Inatsuka, Carol S.; Sheets, Amanda J.; Williams, Corinne L.; Benaron, David J.; Donato, Gina M.; Gray, Mary C.; Hewlett, Erik L.

2012-01-01

Bordetella pertussis and Bordetella bronchiseptica establish respiratory infections with notorious efficiency. Our previous studies showed that the fhaB genes of B. pertussis and B. bronchiseptica, which encode filamentous hemagglutinin (FHA), are functionally interchangeable and provided evidence that FHA-deficient B. bronchiseptica induces more inflammation in the lungs of mice than wild-type B. bronchiseptica. We show here that the robust inflammatory response to FHA-deficient B. bronchiseptica is characterized by the early and sustained influx of interleukin-17 (IL-17)-positive neutrophils and macrophages and, at 72 h postinoculation, IL-17-positive CD4+ T cells, suggesting that FHA allows the bacteria to suppress the development of an IL-17-mediated inflammatory response. We also show that the cyaA genes of B. pertussis and B. bronchiseptica, which encode adenylate cyclase toxin (ACT), are functionally interchangeable and that ACT, specifically its catalytic activity, is required for B. bronchiseptica to resist phagocytic clearance but is neither required for nor inhibitory of the induction of inflammation if bacteria are present in numbers sufficient to persist during the first 3 days postinoculation. Incubation of bone marrow-derived macrophages with a ΔcyaA strain caused decreased production of IL-1β and increased production of tumor necrosis factor alpha (TNF-α) and IL-12, while incubation with a ΔcyaA ΔfhaB strain caused increased production of IL-23. These data suggest that FHA and ACT both contribute to suppress the recruitment of neutrophils and the development of an IL-17-mediated immune response. To our knowledge, this is the first demonstration of a microbial pathogen suppressing IL-17-mediated inflammation in vivo as a strategy to evade innate immunity. PMID:22473603

Uncovering the dual role of RHAMM as an HA receptor and a regulator of CD44 expression in RHAMM-expressing mesenchymal progenitor cells.

PubMed

Veiseh, Mandana; Leith, Sean J; Tolg, Cornelia; Elhayek, Sallie S; Bahrami, S Bahram; Collis, Lisa; Hamilton, Sara; McCarthy, James B; Bissell, Mina J; Turley, Eva

2015-01-01

The interaction of hyaluronan (HA) with mesenchymal progenitor cells impacts trafficking and fate after tissue colonization during wound repair and these events contribute to diseases such as cancer. How this interaction occurs is poorly understood. Using 10T½ cells as a mesenchymal progenitor model and fluorescent (F-HA) or gold-labeled HA (G-HA) polymers, we studied the role of two HA receptors, RHAMM and CD44, in HA binding and uptake in non-adherent and adherent mesenchymal progenitor (10T½) cells to mimic aspects of cell trafficking and tissue colonization. We show that fluorescent labeled HA (F-HA) binding/uptake was high in non-adherent cells but dropped over time as cells became increasingly adherent. Non-adherent cells displayed both CD44 and RHAMM but only function-blocking anti-RHAMM and not anti-CD44 antibodies significantly reduced F-HA binding/uptake. Adherent cells, which also expressed CD44 and RHAMM, primarily utilized CD44 to bind to F-HA since anti-CD44 but not anti-RHAMM antibodies blocked F-HA uptake. RHAMM overexpression in adherent 10T½ cells led to increased F-HA uptake but this increased binding remained CD44 dependent. Further studies showed that RHAMM-transfection increased CD44 mRNA and protein expression while blocking RHAMM function reduced expression. Collectively, these results suggest that cellular microenvironments in which these receptors function as HA binding proteins differ significantly, and that RHAMM plays at least two roles in F-HA binding by acting as an HA receptor in non-attached cells and by regulating CD44 expression and display in attached cells. Our findings demonstrate adhesion-dependent mechanisms governing HA binding/ uptake that may impact development of new mesenchymal cell-based therapies.

Predicting potential distribution of poorly known species with small database: the case of four-horned antelope Tetracerus quadricornis on the Indian subcontinent.

PubMed

Pokharel, Krishna Prasad; Ludwig, Tobias; Storch, Ilse

2016-04-01

Information gaps on the distribution of data deficient and rare species such as four-horned antelope (FHA) in Nepal may impair their conservation. We aimed to empirically predict the distribution of FHA in Nepal with the help of data from the Indian subcontinent. Additionally, we wanted to identify core areas and gaps within the reported range limits and to assess the degree of isolation of known Nepalese populations from the main distribution areas in India. The tropical part of the Indian subcontinent (65°-90° eastern longitude, 5°-30° northern latitude), that is, the areas south of the Himalayan Mountains. Using MaxEnt and accounting for sampling bias, we developed predictive distribution models from environmental and topographical variables, and known presence locations of the study species in India and Nepal. We address and discuss the use of target group vs. random background. The prediction map reveals a disjunct distribution of FHA with core areas in the tropical parts of central to southern-western India. At the scale of the Indian subcontinent, suitable FHA habitat area in Nepal was small. The Indo-Gangetic Plain isolates Nepalese from the Indian FHA populations, but the distribution area extends further south than proposed by the current IUCN map. A low to intermediate temperature seasonality as well as low precipitation during the dry and warm season contributed most to the prediction of FHA distribution. The predicted distribution maps confirm other FHA range maps but also indicate that suitable areas exist south of the known range. Results further highlight that small populations in the Nepalese Terai Arc are isolated from the Indian core distribution and therefore might be under high extinction risk.

Uncovering the dual role of RHAMM as an HA receptor and a regulator of CD44 expression in RHAMM-expressing mesenchymal progenitor cells

PubMed Central

Veiseh, Mandana; Leith, Sean J.; Tolg, Cornelia; Elhayek, Sallie S.; Bahrami, S. Bahram; Collis, Lisa; Hamilton, Sara; McCarthy, James B.; Bissell, Mina J.; Turley, Eva

2015-01-01

The interaction of hyaluronan (HA) with mesenchymal progenitor cells impacts trafficking and fate after tissue colonization during wound repair and these events contribute to diseases such as cancer. How this interaction occurs is poorly understood. Using 10T½ cells as a mesenchymal progenitor model and fluorescent (F-HA) or gold-labeled HA (G-HA) polymers, we studied the role of two HA receptors, RHAMM and CD44, in HA binding and uptake in non-adherent and adherent mesenchymal progenitor (10T½) cells to mimic aspects of cell trafficking and tissue colonization. We show that fluorescent labeled HA (F-HA) binding/uptake was high in non-adherent cells but dropped over time as cells became increasingly adherent. Non-adherent cells displayed both CD44 and RHAMM but only function-blocking anti-RHAMM and not anti-CD44 antibodies significantly reduced F-HA binding/uptake. Adherent cells, which also expressed CD44 and RHAMM, primarily utilized CD44 to bind to F-HA since anti-CD44 but not anti-RHAMM antibodies blocked F-HA uptake. RHAMM overexpression in adherent 10T½ cells led to increased F-HA uptake but this increased binding remained CD44 dependent. Further studies showed that RHAMM-transfection increased CD44 mRNA and protein expression while blocking RHAMM function reduced expression. Collectively, these results suggest that cellular microenvironments in which these receptors function as HA binding proteins differ significantly, and that RHAMM plays at least two roles in F-HA binding by acting as an HA receptor in non-attached cells and by regulating CD44 expression and display in attached cells. Our findings demonstrate adhesion-dependent mechanisms governing HA binding/ uptake that may impact development of new mesenchymal cell-based therapies. PMID:26528478

Contribution of Bordetella bronchiseptica Filamentous Hemagglutinin and Pertactin to Respiratory Disease in Swine▿ †

PubMed Central

Nicholson, Tracy L.; Brockmeier, Susan L.; Loving, Crystal L.

2009-01-01

Bordetella bronchiseptica is pervasive in swine populations and plays multiple roles in respiratory disease. Most studies addressing virulence factors of B. bronchiseptica are based on isolates derived from hosts other than pigs. Two well-studied virulence factors implicated in the adhesion process are filamentous hemagglutinin (FHA) and pertactin (PRN). We hypothesized that both FHA and PRN would serve critical roles in the adhesion process and be necessary for colonization of the swine respiratory tract. To investigate the role of FHA and PRN in Bordetella pathogenesis in swine, we constructed mutants containing an in-frame deletion of the FHA or the PRN structural gene in a virulent B. bronchiseptica swine isolate. Both mutants were compared to the wild-type swine isolate for their ability to colonize and cause disease in swine. Colonization of the FHA mutant was lower than that of the wild type at all respiratory tract sites and time points examined and caused limited to no disease. In contrast, the PRN mutant caused similar disease severity relative to the wild type; however, colonization of the PRN mutant was reduced relative to the wild type during early and late infection and induced higher anti-Bordetella antibody titers. Together, our results indicate that despite inducing different pathologies and antibody responses, both FHA and PRN are necessary for optimal colonization of the swine respiratory tract. PMID:19237531

78 FR 4156 - Notice of Proposed Information Collection: Comment Request; Assisted Living Conversion Program...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-18

... Information Collection: Comment Request; Assisted Living Conversion Program (ALCP) for Eligible Multifamily.... This Notice also lists the following information: Title of Proposal: Assisted Living Conversion Program.... Description of the need for the information and proposed use: The Assisted Living Conversion Program and the...

Endocrine profiles and neuropsychologic correlates of functional hypothalamic amenorrhea in adolescents.

PubMed

Bomba, Monica; Gambera, Alessandro; Bonini, Luisa; Peroni, Maria; Neri, Francesca; Scagliola, Pasquale; Nacinovich, Renata

2007-04-01

To determine trigger factors and neuropsychologic correlates of functional hypothalamic amenorrhea (FHA) in adolescence and to evaluate the correlations with the endocrine-metabolic profile. Cross-sectional comparison of adolescents with FHA and eumenorrheic controls Academic medical institution Twenty adolescent girls with FHA (aged <18 years) and 20 normal cycling girls All subjects underwent endocrine-gynecologic (hormone) and neuropsychiatric (tests and interview) investigations. A separate semistructured interview was also used to investigate parents. Gonadotropins, leptin, prolactin, androgens, estrogens, cortisol, carrier proteins (SHBG, insulin-like growth factor-binding protein 1), and metabolic parameters (insulin, insulin-like growth factor 1, thyroid hormones) were assayed in FHA and control subjects. All girls were evaluated using a test for depression, a test for disordered eating, and a psychodynamic semistructured interview. Adolescents with FHA showed a particular susceptibility to common life events, restrictive disordered eating, depressive traits, and psychosomatic disorders. The endocrine-metabolic profile was strictly correlated to the severity of the psychopathology. Functional hypothalamic amenorrhea in adolescence is due to a particular neuropsychologic vulnerability to stress, probably related to familial relationship styles, expressed by a proportional endocrine impairment.

Polyurethane/fluor-hydroxyapatite nanocomposite scaffolds for bone tissue engineering. Part I: morphological, physical, and mechanical characterization

PubMed Central

Asefnejad, Azadeh; Behnamghader, Aliasghar; Khorasani, Mohammad Taghi; Farsadzadeh, Babak

2011-01-01

In this study, new nano-fluor-hydroxyapatite (nFHA)/polyurethane composite scaffolds were fabricated for potential use in bone tissue engineering. Polyester urethane samples were synthesized from polycaprolactone, hexamethylene diisocyanate, and 1,4-butanediol as chain extender. Nano fluor-hydroxyapatite (nFHA) was successfully synthesized by sol-gel method. The solid–liquid phase separation and solvent sublimation methods were used for preparation of the porous composites. Mechanical properties, chemical structure, and morphological characteristics of the samples were investigated by compressive test, Fourier transform infrared, and scanning electron microscopy (SEM) techniques, respectively. The effect of nFHA powder content on porosity and pore morphology was investigated. SEM images demonstrated that the scaffolds were constituted of interconnected and homogeneously distributed pores. The pore size of the scaffolds was in the range 50–250 μm. The result obtained in this research revealed that the porosity and pore average size decreased and compressive modulus increased with nFHA percentage. Considering morphological, physical, and mechanical properties, the scaffold with a higher ratio of nFHA has suitable potential use in tissue regeneration. PMID:21289986

A Multi-Family Group Intervention for Adolescent Depression: The BEST MOOD Program.

PubMed

Poole, Lucinda A; Lewis, Andrew J; Toumbourou, John W; Knight, Tess; Bertino, Melanie D; Pryor, Reima

2017-06-01

Depression is the most common mental disorder for young people, and it is associated with educational underachievement, self-harm, and suicidality. Current psychological therapies for adolescent depression are usually focused only on individual-level change and often neglect family or contextual influences. The efficacy of interventions may be enhanced with a broader therapeutic focus on family factors such as communication, conflict, support, and cohesion. This article describes a structured multi-family group approach to the treatment of adolescent depression: Behaviour Exchange Systems Therapy for adolescent depression (BEST MOOD). BEST MOOD is a manualized intervention that is designed to address both individual and family factors in the treatment of adolescent depression. BEST MOOD adopts a family systems approach that also incorporates psychoeducation and elements of attachment theories. The program consists of eight multifamily group therapy sessions delivered over 2 hours per week, where parents attend the first four sessions and young people and siblings join from week 5. The program design is specifically aimed to engage youth who are initially resistant to treatment and to optimize youth and family mental health outcomes. This article presents an overview of the theoretical model, session content, and evaluations to date, and provides a case study to illustrate the approach. © 2016 Family Process Institute.

77 FR 26218 - Federal Housing Administration (FHA): Section 232 Healthcare Facility Insurance Program...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-03

... homes must be licensed or regulated by the appropriate state agency, municipality, or other political... debt service payments during a period of instability. Thus, the reserve can delay the point at which a..., but stability could not be achieved prior to the lenders' expenses becoming too burdensome to sustain...

24 CFR 257.401 - Notice of false information from mortgagor-procedure.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Notice of false information from... HOUSING ACT AND OTHER AUTHORITIES HOPE FOR HOMEOWNERS PROGRAM Enforcement Mortgagor False Information § 257.401 Notice of false information from mortgagor-procedure. (a) If FHA finds that the mortgagor has...

24 CFR 200.193 - Responsibilities of 203(k) consultants on the list.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Responsibilities of 203(k... Removal Procedures for Participation in FHA Programs Section 203(k) Rehabilitation Loan Consultants § 200.193 Responsibilities of 203(k) consultants on the list. All consultants included on the list are...

24 CFR 200.190 - HUD list of qualified 203(k) consultants.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false HUD list of qualified 203(k... Participation in FHA Programs Section 203(k) Rehabilitation Loan Consultants § 200.190 HUD list of qualified 203(k) consultants. (a) Qualified consultant list. HUD maintains a list of qualified consultants for use...

24 CFR 200.190 - HUD list of qualified 203(k) consultants.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false HUD list of qualified 203(k... Participation in FHA Programs Section 203(k) Rehabilitation Loan Consultants § 200.190 HUD list of qualified 203(k) consultants. (a) Qualified consultant list. HUD maintains a list of qualified consultants for use...

24 CFR 200.193 - Responsibilities of 203(k) consultants on the list.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Responsibilities of 203(k... Removal Procedures for Participation in FHA Programs Section 203(k) Rehabilitation Loan Consultants § 200.193 Responsibilities of 203(k) consultants on the list. All consultants included on the list are...

24 CFR 200.193 - Responsibilities of 203(k) consultants on the list.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Responsibilities of 203(k... Removal Procedures for Participation in FHA Programs Section 203(k) Rehabilitation Loan Consultants § 200.193 Responsibilities of 203(k) consultants on the list. All consultants included on the list are...

24 CFR 200.190 - HUD list of qualified 203(k) consultants.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false HUD list of qualified 203(k... Participation in FHA Programs Section 203(k) Rehabilitation Loan Consultants § 200.190 HUD list of qualified 203(k) consultants. (a) Qualified consultant list. HUD maintains a list of qualified consultants for use...

24 CFR 200.193 - Responsibilities of 203(k) consultants on the list.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Responsibilities of 203(k... Removal Procedures for Participation in FHA Programs Section 203(k) Rehabilitation Loan Consultants § 200.193 Responsibilities of 203(k) consultants on the list. All consultants included on the list are...

24 CFR 200.190 - HUD list of qualified 203(k) consultants.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false HUD list of qualified 203(k... Participation in FHA Programs Section 203(k) Rehabilitation Loan Consultants § 200.190 HUD list of qualified 203(k) consultants. (a) Qualified consultant list. HUD maintains a list of qualified consultants for use...

24 CFR 200.190 - HUD list of qualified 203(k) consultants.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false HUD list of qualified 203(k... Participation in FHA Programs Section 203(k) Rehabilitation Loan Consultants § 200.190 HUD list of qualified 203(k) consultants. (a) Qualified consultant list. HUD maintains a list of qualified consultants for use...

24 CFR 200.193 - Responsibilities of 203(k) consultants on the list.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Responsibilities of 203(k... Removal Procedures for Participation in FHA Programs Section 203(k) Rehabilitation Loan Consultants § 200.193 Responsibilities of 203(k) consultants on the list. All consultants included on the list are...

75 FR 71723 - Policies and Procedures Pertaining to Changes in Listing Brokers Participating in the Federal...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-24

... estate brokers may participate as Listing or Selling brokers under FHA's Management and Marketing III (M... disposition of its REO inventory to private sector contractors under the Management and Marketing (M&M..., program support, management and marketing services throughout the United States, the Caribbean, Guam and...

24 CFR 200.800 - Lead-based paint.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Lead-based paint. 200.800 Section... DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Lead-Based Paint Poisoning Prevention § 200.800 Lead-based paint. The Lead-Based Paint Poisoning Prevention Act (42 U.S.C. 4821-4846), the Residential Lead-Based...

24 CFR 200.800 - Lead-based paint.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Lead-based paint. 200.800 Section... DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Lead-Based Paint Poisoning Prevention § 200.800 Lead-based paint. The Lead-Based Paint Poisoning Prevention Act (42 U.S.C. 4821-4846), the Residential Lead-Based...

24 CFR 200.800 - Lead-based paint.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Lead-based paint. 200.800 Section... DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Lead-Based Paint Poisoning Prevention § 200.800 Lead-based paint. The Lead-Based Paint Poisoning Prevention Act (42 U.S.C. 4821-4846), the Residential Lead-Based...

24 CFR 200.800 - Lead-based paint.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Lead-based paint. 200.800 Section... DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Lead-Based Paint Poisoning Prevention § 200.800 Lead-based paint. The Lead-Based Paint Poisoning Prevention Act (42 U.S.C. 4821-4846), the Residential Lead-Based...

78 FR 8329 - Federal Housing Administration (FHA): Hospital Mortgage Insurance Program-Refinancing Hospital Loans

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-05

... rehabilitation, and equipment purchases. However, when the credit markets became more restrictive in 2008... than 20 percent eligible to be used for construction and/or equipment. The rule establishes threshold..., renovations, and/or equipment to be financed with mortgage proceeds and how those repairs, renovations, and/or...

24 CFR 200.800 - Lead-based paint.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Lead-based paint. 200.800 Section... DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Lead-Based Paint Poisoning Prevention § 200.800 Lead-based paint. The Lead-Based Paint Poisoning Prevention Act (42 U.S.C. 4821-4846), the Residential Lead-Based...

Polycystic Ovary-Like Abnormalities (PCO-L) in women with functional hypothalamic amenorrhea.

PubMed

Robin, G; Gallo, C; Catteau-Jonard, S; Lefebvre-Maunoury, C; Pigny, P; Duhamel, A; Dewailly, D

2012-11-01

In the general population, about 30% of asymptomatic women have polycystic ovary-like abnormalities (PCO-L), i.e. polycystic ovarian morphology (PCOM) at ultrasound and/or increased anti-Müllerian hormone (AMH) serum level. PCOM has also been reported in 30-50% of women with functional hypothalamic amenorrhea (FHA). The aim of this study was to verify whether both PCOM and excessive AMH level indicate PCO-L in FHA and to elucidate its significance. We conducted a retrospective analysis using a database and comparison with a control population. Subjects received ambulatory care in an academic hospital. Fifty-eight patients with FHA were compared to 217 control women with nonendocrine infertility and body mass index of less than 25 kg/m(2). There were no interventions. We measured serum testosterone, androstenedione, FSH, LH, AMH, and ovarian area values. The antral follicle count (AFC) was used as a binary variable (i.e. negative or positive) because of the evolution of its sensitivity over the time of this study. The ability of these variables (except AFC) to detect PCO-L in both populations was tested by cluster analysis. One cluster (cluster 2) suggesting PCO-L was detected in the control population (n = 52; 24%), whereas two such clusters were observed in the FHA population (n = 22 and n = 6; 38 and 10%; clusters 2 and 3, respectively). Cluster 2 in FHA had similar features of PCO-L as cluster 2 in controls, with higher prevalence of positive AFC (70%) and PCOM (70%), higher values of ovarian area and higher serum AMH (P < 0.0001 for all), and testosterone levels (P < 0.01) than in cluster 1. Cluster 3 in FHA was peculiar, with frankly elevated AMH levels. In the whole population (controls + FHA), PCO-L was significantly associated with lower FSH values (P < 0.0001). PCO-L in FHA is a frequent and usually incidental finding of unclear significance, as in controls. The association of PCO-L with hypothalamic amenorrhea should not lead to a mistaken diagnosis of PCOS.

Impaired vascular function in physically active premenopausal women with functional hypothalamic amenorrhea is associated with low shear stress and increased vascular tone.

PubMed

O'Donnell, Emma; Goodman, Jack M; Mak, Susanna; Harvey, Paula J

2014-05-01

Exercise-trained hypoestrogenic premenopausal women with functional hypothalamic amenorrhea (ExFHA) exhibit impaired endothelial function. The vascular effects of an acute bout of exercise, a potent nitric oxide stimulus, in these women are unknown. Three groups were studied: recreationally active ExFHA women (n = 12; 24.2 ± 1.2 years of age; mean ± SEM), and recreationally active (ExOv; n = 14; 23.5 ± 1.2 years of age) and sedentary (SedOv; n = 15; 23.1 ± 0.5 years of age) ovulatory eumenorrheic women. Calf blood flow (CBF) and brachial artery flow-mediated dilation (FMD) were evaluated using plethysmographic and ultrasound techniques, respectively, both before and 1 hour after 45 minutes of moderate-intensity exercise. Endothelium-independent dilation was assessed at baseline using glyceryl trinitrate. Calf vascular resistance (CVR) and brachial peak shear rate, as determined by the area under the curve (SRAUCpk), were also calculated. FMD and glyceryl trinitrate responses were lower (P < .05) in ExFHA (2.8% ± 0.4% and 11.6% ± 0.7%, respectively) than ExOv (8.8% ± 0.7% and 16.7% ± 1.3%) and SedOv (8.0% ± 0.5% and 17.1% ± 1.8%). SRAUCpk was also lower (P < .05) in ExFHA. Normalization of FMD for SRAUCpk (FMD/SRAUCpk) did not alter (P > .05) the findings. CBF was lower (P < .05) and CVR higher (P < .05) in ExFHA. After exercise, FMD and SRAUCpk were augmented (P < .05), but remained lower (P < .05), in ExFHA. FMD/SRAUCpk no longer differed (P > .05) between the groups. CBF in ExFHA was increased (P < .05) and CVR decreased (P < .05) to levels observed in ovulatory women. Acute dynamic exercise improves vascular function in ExFHA women. Although the role of estrogen deficiency per se is unclear, our findings suggest that low shear rate and increased vasoconstrictor tone may play a role in impaired basal vascular function in these women.

24 CFR 266.1 - Purpose and scope.

Code of Federal Regulations, 2010 CFR

2010-04-01

... FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS General Provisions... specifically directs the Secretary to carry out a pilot program of risk-sharing with qualified State and local... under this program. Through risk-sharing agreements with HUD, HFAs contract to reimburse HUD for a...

Estriol administration modulates luteinizing hormone secretion in women with functional hypothalamic amenorrhea.

PubMed

Genazzani, Alessandro D; Meczekalski, Blazej; Podfigurna-Stopa, Agnieszka; Santagni, Susanna; Rattighieri, Erica; Ricchieri, Federica; Chierchia, Elisa; Simoncini, Tommaso

2012-02-01

To evaluate the influence of estriol administration on the hypothalamus-pituitary function and gonadotropins secretion in patients affected by functional hypothalamic amenorrhea (FHA). Controlled clinical study. Patients with FHA in a clinical research environment. Twelve hypogonadotropic patients affected by FHA. Pulsatility study of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), and a gonadotropin-releasing hormone (GnRH) test (10 μg in bolus) at baseline condition and after 8 weeks of therapy with 2 mg/day of estriol. Measurements of plasma LH, FSH, estradiol (E(2)), androstenedione (A), 17α-hydroxyprogesterone (17-OHP), cortisol, androstenedione (A), testosterone (T), thyroid-stimulating hormone (TSH), free triiodothyronine (fT(3)), free thyroxine (fT(4)), and insulin, and pulse detection. After treatment, the FHA patients showed a statistically significant increase of LH plasma levels (from 0.7 ± 0.1 mIU/mL to 3.5 ± 0.3 mIU/mL) and a statistically significant increase of LH pulse amplitude with no changes in LH pulse frequency. In addition, the LH response to the GnRH bolus was a statistically significant increase. Estriol administration induced the increase of LH plasma levels in FHA and improved GnRH-induced LH secretion. These findings suggest that estriol administration modulates the neuroendocrine control of the hypothalamus-pituitary unit and induces the recovery of LH synthesis and secretion in hypogonadotropic patients with FHA. Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

Diurnal Variation of Plasma Brain-Derived Neurotrophic Factor Levels in Women with Functional Hypothalamic Amenorrhea.

PubMed

Drakopoulos, Panagiotis; Casarosa, Elena; Bucci, Fiorella; Piccinino, Manuela; Wenger, Jean-Marie; Nappi, Rossella Elena; Polyzos, Nicholas; Genazzani, Andrea Riccardo; Pluchino, Nicola

2015-01-01

Brain-derived neurotrophic factor (BDNF) is strongly related to hormonal networks and is modulated by hypothalamic activity. To evaluate plasma BDNF concentration in patients with functional hypothalamic amenorrhea (FHA), with reference to the BDNF circadian rhythm and its relation with the cortisol (F) rhythm, and to assess whether the duration of amenorrhea might influence the BDNF:F ratio in FHA. This was an observational study evaluating 36 amenorrheic and 30 eumenorrheic women. Basal values of BDNF and hormones were examined in blood samples collected from 7:00 to 9:00 h in all the women. Basal BDNF and F levels were determined in blood samples collected in 12 subjects from each group at 8:00, 12:00, 16:00, 20:00, and 24:00 h. BDNF plasma levels are significantly lower in amenorrheic women (p < 0.001) than in the follicular phase of eumenorrheic women. There are no correlations between BDNF values (p > 0.05), sex steroids, and F in FHA. Low plasma BDNF levels in FHA are not significantly correlated with duration of amenorrhea. The 24-hour variation of BDNF in amenorrheic women is significantly lower when compared to the control group, and normal daily variations of BDNF disappeared in FHA patients. F preserved its circadian rhythm in both groups. Interactions between BDNF, the hypothalamus-pituitary-adrenal axis, and sex steroids might be critical in clinical conditions of modified homeostasis/adaptation, such as FHA. © 2015 S. Karger AG, Basel.

7 CFR 3560.52 - Program objectives.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 15 2011-01-01 2011-01-01 false Program objectives. 3560.52 Section 3560.52... AGRICULTURE DIRECT MULTI-FAMILY HOUSING LOANS AND GRANTS Direct Loan and Grant Origination § 3560.52 Program... areas. The Agency encourages the use of such financing in conjunction with funding or financing from...

7 CFR 3560.52 - Program objectives.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 15 2014-01-01 2014-01-01 false Program objectives. 3560.52 Section 3560.52... AGRICULTURE DIRECT MULTI-FAMILY HOUSING LOANS AND GRANTS Direct Loan and Grant Origination § 3560.52 Program... areas. The Agency encourages the use of such financing in conjunction with funding or financing from...

7 CFR 3560.602 - Program objectives.

Code of Federal Regulations, 2010 CFR

2010-01-01

... AGRICULTURE DIRECT MULTI-FAMILY HOUSING LOANS AND GRANTS On-Farm Labor Housing § 3560.602 Program objectives. In addition to the objectives stated in § 3560.52, on-farm labor housing funds will be used to... 7 Agriculture 15 2010-01-01 2010-01-01 false Program objectives. 3560.602 Section 3560.602...

7 CFR 3560.552 - Program objectives.

Code of Federal Regulations, 2010 CFR

2010-01-01

... AGRICULTURE DIRECT MULTI-FAMILY HOUSING LOANS AND GRANTS Off-Farm Labor Housing § 3560.552 Program objectives. (a) In addition to the objectives stated in § 3560.52, off-farm labor housing loan and grant funds... 7 Agriculture 15 2010-01-01 2010-01-01 false Program objectives. 3560.552 Section 3560.552...

24 CFR 290.7 - Occupancy requirements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.7 Occupancy requirements. (a) Multifamily housing project that is HUD-owned or for which HUD is mortgagee-in-possession. Occupancy in a multifamily...

24 CFR 290.7 - Occupancy requirements.

Code of Federal Regulations, 2012 CFR

2012-04-01

... URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.7 Occupancy requirements. (a) Multifamily housing project that is HUD-owned or for which HUD is mortgagee-in-possession. Occupancy in a multifamily...

24 CFR 290.7 - Occupancy requirements.

Code of Federal Regulations, 2014 CFR

2014-04-01

... URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.7 Occupancy requirements. (a) Multifamily housing project that is HUD-owned or for which HUD is mortgagee-in-possession. Occupancy in a multifamily...

24 CFR 290.7 - Occupancy requirements.

Code of Federal Regulations, 2011 CFR

2011-04-01

... URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.7 Occupancy requirements. (a) Multifamily housing project that is HUD-owned or for which HUD is mortgagee-in-possession. Occupancy in a multifamily...

75 FR 28632 - Federal Housing Administration (FHA)-Temporary Exemption From Compliance With FHA's Regulation on...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-21

... and balconies, walkways and driveways. iii The roofing, plumbing systems, electrical systems, heating and air conditioning systems; iv. All interiors; and v. All insulation and ventilation systems, as...

76 FR 39118 - Notice of Proposed Information Collection: Comment Request; Multifamily Insurance Benefits Claims...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-05

... Information Collection: Comment Request; Multifamily Insurance Benefits Claims Package AGENCY: Office of the..., Multifamily Insurance Operations Division, Multifamily Claims Branch, Department of Housing and Urban... also lists the following information: Title of Proposal: Multifamily Insurance Benefits Claims Package...

Rethinking multifamily resets and cutouts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jablonski, F.

In multifamily applications, where heating bills often run into thousands of dollars, reset-cutout combinations appear to be very attractive retrofits because, when properly operated, they meet owners' needs for very quick returns on energy saving investments. Unfortunately, the author's observation of resets and cutouts operating under conditions the author typically found in residential multifamily buildings indicates that adjustable controls, such as most resets and cutouts, will often be defeated through poor installation and maladjustment. This appears to be true even when programs incorporate mechanisms aimed at training building operators to manage the controls correctly, and reinforce that training with writtenmore » instructions and periodic reminders. Despite the massive and frequently reinforced education effort for control operators, his post-installation site visits revealed that resets and cutouts were still routinely defeated. Out of curiosity, he conducted a survey of cutout controls in spring 1990. The author has found that 19 of 19 cutout controls surveyed, all of which had been installed under the enhanced program, were rendered functionally inoperable because they were turned off or set far too high. Because this preliminary survey showed such poor results, additional research is now underway to assess the maintenance or disablement of these adjustable resets and cutouts.« less

[Psychoeducation and multifamily groups for patients with first-episode psychosis].

PubMed

Lyse, Hanne-Grethe; Haahr, Ulrik Helt; Fjell, Anne; Dichmann, Bente; Flensborg, Estrid; Simonsen, Erik

2007-10-22

In spite of existing good evidence of the efficacy of extended intervention in families with a member diagnosed as schizophrenic, this intervention is not in general use in Denmark. This paper describes experiences of psychoeducation and multifamily group from the TIPS project (Early Intervention in Psychosis). 55 patients were enrolled in the Danish part of the project. The 2-year manualized treatment program consisted of pharmacotherapy, psychotherapy and family intervention. The family intervention included joining sessions, information days and multifamily group. Of the 55 enrolled 31 patients and their families had joining sessions; 20 completed the full treatment program. They were younger patients, more often living with their families, and differed diagnostically to some extent from the other patients. Lack of acceptance from the patients or families and too far to the treatment site were the main reasons for not participating. The study indicates the necessity to offer a more phase-specific family intervention to include more patients and their families. Due to the low incidence of first-episode psychosis it is necessary that treatment centres coordinate their treatment in order to facilitate the establishment of homogenous groups and to develop coordinated education and supervision.

76 FR 53362 - Approval of Farm Credit System Lending Institutions in FHA Mortgage Insurance Programs

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-26

... rates, and provide financial services and advice to those persons and businesses. Federal oversight by... Agricultural Credit Associations that, in turn, provide short-, intermediate-, and long-term credit to farmers... financial strength of all of the Farm Credit banks stands behind the debt issued on behalf of the Farm...

77 FR 9177 - Federal Housing Administration (FHA): Suspension of Section 238(c) Single-Family Mortgage...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-16

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT 24 CFR Part 203 [Docket No. FR-5461-F-02] RIN 2502..., Director, Office of Single Family Program Development, Office of Housing, Department of Housing and Urban... the private sector. This rule does not impose any federal mandates on any state, local, or tribal...

75 FR 4963 - Federal Housing Administration (FHA): Hospital Mortgage Insurance Program-Refinancing Hospital Loans

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-29

... impact on hospitals across the Nation. At a time when the demand for health care services is on the rise... capital to help hospitals refinance debt was sufficiently available, and that the demand for this type of... nursing home, existing assisted living facility, existing intermediate care facility, existing board and...

24 CFR 35.620 - Multifamily insured property constructed before 1960.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Multifamily insured property... STRUCTURES Multifamily Mortgage Insurance § 35.620 Multifamily insured property constructed before 1960. Except as provided in § 35.630, the following requirements apply to multifamily insured property...

24 CFR 35.620 - Multifamily insured property constructed before 1960.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Multifamily insured property... STRUCTURES Multifamily Mortgage Insurance § 35.620 Multifamily insured property constructed before 1960. Except as provided in § 35.630, the following requirements apply to multifamily insured property...

24 CFR 35.620 - Multifamily insured property constructed before 1960.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Multifamily insured property... STRUCTURES Multifamily Mortgage Insurance § 35.620 Multifamily insured property constructed before 1960. Except as provided in § 35.630, the following requirements apply to multifamily insured property...

24 CFR 266.507 - Maintenance requirements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and Servicing § 266.507 Maintenance requirements. The mortgagor must maintain the project in...

24 CFR 266.105 - Application requirements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Housing Finance Agency Requirements § 266.105 Application requirements. (a) Applications for approval as a HUD...

24 CFR 266.507 - Maintenance requirements.

Code of Federal Regulations, 2011 CFR

2011-04-01

... HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and Servicing § 266.507 Maintenance requirements. The mortgagor must maintain the project in...

24 CFR 266.507 - Maintenance requirements.

Code of Federal Regulations, 2014 CFR

2014-04-01

... HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and Servicing § 266.507 Maintenance requirements. The mortgagor must maintain the project in...

24 CFR 266.507 - Maintenance requirements.

Code of Federal Regulations, 2012 CFR

2012-04-01

... HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and Servicing § 266.507 Maintenance requirements. The mortgagor must maintain the project in...

24 CFR 266.507 - Maintenance requirements.

Code of Federal Regulations, 2013 CFR

2013-04-01

... HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and Servicing § 266.507 Maintenance requirements. The mortgagor must maintain the project in...

75 FR 76482 - Federal Housing Administration (FHA): FHA Maximum Loan Limits for 2011

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-08

... http://www.hud.gov/offices/adm/hudclips/letters/mortgagee/ . FOR FURTHER INFORMATION CONTACT: Karin B... be found at http://www.hud.gov/offices/adm/hudclips/letters/mortgagee/ mortgagee/. Dated: November 29...

7 CFR 1956.100 - OMB control number.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS...) PROGRAM REGULATIONS (CONTINUED) DEBT SETTLEMENT Debt Settlement-Farm Loan Programs and Multi-Family... been approved by the Office of Management and Budget and assigned OMB control number 0575-0118. Public...

APPLICATION OF FORMOHYDROXAMIC ACID IN NUCLEAR PROCESSING: SYNTHESIS AND COMPLEXATION WITH TECHNETIUM-99

DOE Office of Scientific and Technical Information (OSTI.GOV)

Amber Wright; Edward Mausolf; Keri Campbell

2010-05-01

Acetohydroxamic acid (AHA) is an organic ligand planned for use in the Uranium Extraction (UREX) process. It reduces neptunium and plutonium, and the resultant hydrophilic complexes are separated from uranium by extraction with tributyl phosphate (TBP) in a hydrocarbon diluent. AHA undergoes hydrolysis to acetic acid which will impede the recycling of nitric acid. During recent discussions of the UREX process, it has been proposed to replace AHA by formohydroxamic acid (FHA). FHA will undergo hydrolysis to formic acid which is volatile, thus allowing the recycling of nitric acid. The reported reduction potentials of AHA and pertechnetate (TcO{sub 4}{sup -})more » indicated that it may be possible for AHA to reduce technetium, altering its fate in the fuel cycle. At UNLV, it has been demonstrated that TcO{sub 4}{sup -} undergoes reductive nitrosylation by AHA under a variety of conditions. The resulting divalent technetium is complexed by AHA to form the pseudo-octahedral trans-aquonitrosyl (diacetohydroxamic)-technetium(II) complex ([Tc{sup II}(NO)(AHA){sub 2}H{sub 2}O]{sup +}). In this paper, we are reporting the synthesis of FHA and its complex formation with technetium along with the characterization of FHA crystals achieved by NMR and IR spectroscopy. Two experiments were conducted to investigate the complexation of FHA with Tc and the results were compared with previous data on AHA. The first experiment involved the elution of Tc from a Reillex HP anion exchange resin, and the second one monitored the complexation of technetium with FHA by UV-visible spectrophotometry.« less

Resumption of menstruation and pituitary response to gonadotropin-releasing hormone in functional hypothalamic amenorrhea subjects undertaking estrogen replacement therapy.

PubMed

Shen, Z Q; Xu, J J; Lin, J F

2013-11-01

Functional hypothalamic amenorrhea (FHA) refers to a functional menstrual disorder with various causes and presentations. Recovery of menstrual cyclicity is common in long-term follow-up but the affecting factors remain unknown. To explore factors affecting the menstrual resumption and to evaluate the pituitary response to gonadotropin-releasing hormone (GnRH) in FHA. Thirty cases with FHA were recruited. All subjects were put on continuous 1 mg/day estradiol valerate orally and followed up monthly. Recovery was defined as the occurrence of at least three consecutive regular cycles. Responder referred to those who recovered within two years of therapy. Gonadotropin response to the 50 μg GnRH challenge was tested every three months. Nineteen (63.3%) subjects recovered with a mean time to recovery of 26.8 months. Time to recovery was negatively correlated with body mass index (BMI) before and by amenorrhea. Twentyone cases had undertaken therapy for more than two years and 10 of them recovered. BMI before and by amenorrhea were negatively correlated with the recovery. Significant increase of serum luteinizing hormone (LH) and LH response to GnRH were noted after recovery. Menstrual resumption was common in FHA undertaking estrogen replacement therapy (ERT). The likelihood of recovery was affected by their BMI before and by amenorrhea but not by the weight gain during therapy. Low serum LH and attenuated LH response to GnRH were the main features of pituitary deficiency in FHA. The menstrual resumption in FHA was accompanied by the recovery of serum LH and the LH response to GnRH.

Forkhead-Associated Domain of Yeast Xrs2, a Homolog of Human Nbs1, Promotes Nonhomologous End Joining Through Interaction With a Ligase IV Partner Protein, Lif1

PubMed Central

Matsuzaki, Kenichiro; Shinohara, Akira; Shinohara, Miki

2008-01-01

DNA double-strand breaks (DSB) are repaired through two different pathways, homologous recombination (HR) and nonhomologous end joining (NHEJ). Yeast Xrs2, a homolog of human Nbs1, is a component of the Mre11-Rad50-Xrs2 (MRX) complex required for both HR and NHEJ. Previous studies showed that the N-terminal forkhead-associated (FHA) domain of Xrs2/Nbs1 in yeast is not involved in HR, but is likely to be in NHEJ. In this study, we showed that the FHA domain of Xrs2 plays a critical role in efficient DSB repair by NHEJ. The FHA domain of Xrs2 specifically interacts with Lif1, a component of the ligase IV complex, Dnl4-Nej1-Lif1 (DNL). Lif1, which is phosphorylated in vivo, contains two Xrs2-binding regions. Serine 383 of Lif1 plays an important role in the interaction with Xrs2 as well as in NHEJ. Interestingly, the phospho-mimetic substitutions of serine 383 enhance the NHEJ activity of Lif1. Our results suggest that the phosphorylation of Lif1 at serine 383 is recognized by the Xrs2 FHA domain, which in turn may promote recruitment of the DNL complex to DSB for NHEJ. The interaction between Xrs2 and Lif1 through the FHA domain is conserved in humans; the FHA domain Nbs1 interacts with Xrcc4, a Lif1 homolog of human. PMID:18458108

24 CFR 266.110 - Reserve requirements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Housing Finance Agency Requirements § 266.110 Reserve requirements. (a) HFAs with top-tier designation or overall...

National impacts of the Weatherization Assistance Program in single-family and small multifamily dwellings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brown, M.A.; Berry, L.G.; Balzer, R.A.

1993-05-01

Since 1976, the US Department of Energy (DOE) has operated one of the largest energy conservation programs in the nation -- the low-income Weatherization Assistance Program. The program strives to increase the energy efficiency of dwellings occupied by low-income persons in order to reduce their energy consumption, lower their fuel bills, increase the comfort of their homes, and safeguard their health. It targets vulnerable groups including the elderly, people with disabilities, and families with children. The most recent national evaluation of the impacts of the Program was completed in 1984 based on energy consumption data for households weatherized in 1981.more » DOE Program regulations and operations have changed substantially since then: new funding sources, management principles, diagnostic procedures, and weatherization technologies have been incorporated. Many of these new features have been studied in isolation or at a local level; however, no recent evaluation has assessed their combined, nationwide impacts to date or their potential for the future. In 1990, DOE initiated such an evaluation. This evaluation is comprised of three ``impact`` studies (the Single-Family Study, High-Density Multifamily Study, and Fuel-Oil Study) and two ``policy`` studies. Altogether, these five studies will provide a comprehensive national assessment of the Weatherization Assistance Program as it existed in the 1989 Program Year (PY 1989). This report presents the results of the first phase of the Single-Family Study. It evaluates the energy savings and cost effectiveness of the Program as it has been applied to the largest portion of its client base -- low-income households that occupy single-family dwellings, mobile homes, and small (2- to 4-unit) multifamily dwellings. It is based upon a representative national sample that covers the full range of conditions under which the program was implemented in PY 1989.« less

24 CFR 8.25 - Public housing and multi-family Indian housing.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Public housing and multi-family... multi-family Indian housing. (a) Development and alteration of public housing and multi-family Indian...-family Indian housing. (2) The requirements of § 8.23 shall apply to public housing and multi-family...

24 CFR 8.25 - Public housing and multi-family Indian housing.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Public housing and multi-family... multi-family Indian housing. (a) Development and alteration of public housing and multi-family Indian...-family Indian housing. (2) The requirements of § 8.23 shall apply to public housing and multi-family...

24 CFR 8.25 - Public housing and multi-family Indian housing.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Public housing and multi-family... multi-family Indian housing. (a) Development and alteration of public housing and multi-family Indian...-family Indian housing. (2) The requirements of § 8.23 shall apply to public housing and multi-family...

24 CFR 8.25 - Public housing and multi-family Indian housing.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Public housing and multi-family... multi-family Indian housing. (a) Development and alteration of public housing and multi-family Indian...-family Indian housing. (2) The requirements of § 8.23 shall apply to public housing and multi-family...

24 CFR 8.25 - Public housing and multi-family Indian housing.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Public housing and multi-family... multi-family Indian housing. (a) Development and alteration of public housing and multi-family Indian...-family Indian housing. (2) The requirements of § 8.23 shall apply to public housing and multi-family...

A genetically inactivated two-component acellular pertussis vaccine, alone or combined with tetanus and reduced-dose diphtheria vaccines, in adolescents: a phase 2/3, randomised controlled non-inferiority trial.

PubMed

Sricharoenchai, Sirintip; Sirivichayakul, Chukiat; Chokephaibulkit, Kulkanya; Pitisuttithum, Punnee; Dhitavat, Jittima; Pitisuthitham, Arom; Phongsamart, Wanatpreeya; Boonnak, Kobporn; Lapphra, Keswadee; Sabmee, Yupa; Wittawatmongkol, Orasri; Chinwangso, Pailinrut; Poredi, Indrajeet Kumar; Petre, Jean; Thai, Pham Hong; Viviani, Simonetta

2018-01-01

Increasing evidence shows that protection induced by acellular pertussis vaccines is short-lived, requiring repeated booster vaccination to control pertussis disease. We aimed to assess the safety and immunogenicity of a recombinant acellular pertussis vaccine containing genetically inactivated pertussis toxin and filamentous haemagglutinin, as either a monovalent vaccine (aP [PTgen/FHA] ) or in combination with tetanus and reduced-dose diphtheria vaccines (TdaP [PTgen/FHA] ), versus a licensed tetanus and reduced-dose diphtheria and acellular pertussis combination vaccine (Tdap). We did this phase 2/3, randomised controlled non-inferiority trial at two sites in Bangkok, Thailand. Healthy adolescents (aged 12-17 years) were randomly assigned (1:1:1), via a computer-generated randomisation list with block sizes of three, to receive one dose (0·5 mL) of aP (PTgen/FHA) , TdaP (PTgen/FHA) , or Tdap (comparator). Clinical research staff responsible for participant randomisation, vaccine preparation and administration, and accountability were aware of group allocation. However, allocation was concealed from all other site study staff, data management personnel, statisticians, laboratory staff, and study participants. The primary outcome was non-inferior immunogenicity of TdaP (PTgen/FHA) to Tdap based on seroconversion rates (a four-fold increase or more) for pertussis toxin and filamentous haemagglutinin IgG antibodies 28 days after vaccination, with a predefined 10% margin of equivalence. We did analysis by per protocol. This study is registered with the Thai Clinical Trial Registry, number TCTR20150703002. Between July 6 and Aug 20, 2015, we allocated 450 participants to receive one dose of TdaP (PTgen/FHA) (n=150), aP (PTgen/FHA) (n=150), or comparator Tdap (n=150). 28 days after vaccination, seroconversion rates for anti-pertussis toxin IgG were 96·6% (95% CI 93·8-99·5; n=144) in the TdaP (PTgen/FHA) group and 55·0% (47·1-63·0; n=82) in the comparator Tdap group (difference 41·6%, 95% CI 33·1-50·1; p<0·0001). Seroconversion rates for anti-filamentous haemagglutinin were 82·6% (95% CI 76·5-88·6; n=123) in the TdaP (PTgen/FHA) group and 54·4% (46·4-62·4; n=81) in the comparator group (difference 28·2%, 95% CI 18·1-38·2 p<0·0001). 28 days after vaccination, seroconversion rates in the aP (PTgen/FHA) group were 96·0% (95% CI 92·8-99·1; n=142) for anti-pertussis toxin IgG and 93·2% (89·2-97·3; n=138) for anti-filamentous haemagglutinin IgG. These findings support the non-inferior immunogenicity of TdaP (PTgen/FHA) over comparator Tdap. Reactogenicity and incidence of adverse events were similar between groups. The new TdaP (PTgen/FHA) vaccine is safe and induces higher pertussis responses 28 days after vaccination than does the available licensed Tdap booster vaccine. Results of our trial led to the licensure of new acellular pertussis vaccines containing genetically inactivated pertussis toxin in Thailand. The availability of recombinant monovalent pertussis vaccines that induce high antibody responses provides the medical community and consumers with the opportunity to vaccinate against pertussis when immunisation against diphtheria and tetanus is not required or not desired. Studies are underway to pave the way for licensure studies of this acellular pertussis vaccine in other countries. BioNet-Asia. Copyright © 2018 Elsevier Ltd. All rights reserved.

24 CFR 266.115 - Program monitoring and evaluation.

Code of Federal Regulations, 2010 CFR

2010-04-01

... relative to project management and servicing (including disposition) will be required after endorsement. (2... AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS... principal balances on mortgages the HFA has underwritten, and the status of all projects insured under this...

24 CFR 266.115 - Program monitoring and evaluation.

Code of Federal Regulations, 2013 CFR

2013-04-01

... relative to project management and servicing (including disposition) will be required after endorsement. (2... AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS... principal balances on mortgages the HFA has underwritten, and the status of all projects insured under this...

24 CFR 266.115 - Program monitoring and evaluation.

Code of Federal Regulations, 2011 CFR

2011-04-01

... relative to project management and servicing (including disposition) will be required after endorsement. (2... AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS... principal balances on mortgages the HFA has underwritten, and the status of all projects insured under this...

24 CFR 266.115 - Program monitoring and evaluation.

Code of Federal Regulations, 2012 CFR

2012-04-01

... relative to project management and servicing (including disposition) will be required after endorsement. (2... AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS... principal balances on mortgages the HFA has underwritten, and the status of all projects insured under this...

76 FR 38199 - Notice of Submission of Proposed Information Collection to OMB Prepayment of Direct Loans on...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-29

... Inclusion of FHA Mortgage Guidelines AGENCY: Office of the Chief Information Officer, HUD. ACTION: Notice... Projects with Inclusion of FHA Mortgage Guidelines. OMB Approval Number: 2502-0554. Form Numbers: HUD-9808...

24 CFR 290.25 - Determination not to preserve a project or a part of a project.

Code of Federal Regulations, 2011 CFR

2011-04-01

... MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.25... dispose of, a HUD-owned multifamily housing project, or any portion of such a project, or to foreclose a HUD-held mortgage on a multifamily housing project, without ensuring its continued availability as...

24 CFR 290.25 - Determination not to preserve a project or a part of a project.

Code of Federal Regulations, 2014 CFR

2014-04-01

... MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.25... dispose of, a HUD-owned multifamily housing project, or any portion of such a project, or to foreclose a HUD-held mortgage on a multifamily housing project, without ensuring its continued availability as...

24 CFR 290.25 - Determination not to preserve a project or a part of a project.

Code of Federal Regulations, 2010 CFR

2010-04-01

... MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.25... dispose of, a HUD-owned multifamily housing project, or any portion of such a project, or to foreclose a HUD-held mortgage on a multifamily housing project, without ensuring its continued availability as...

24 CFR 290.25 - Determination not to preserve a project or a part of a project.

Code of Federal Regulations, 2012 CFR

2012-04-01

... MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.25... dispose of, a HUD-owned multifamily housing project, or any portion of such a project, or to foreclose a HUD-held mortgage on a multifamily housing project, without ensuring its continued availability as...

24 CFR 200.620 - Requirements.

Code of Federal Regulations, 2011 CFR

2011-04-01

... marketing program shall be in effect for each multifamily project throughout the life of the mortgage. Such... opportunities regardless of race, color, religion, sex, handicap or familial status or national origin, through...

Skeletal status and body composition in young women with functional hypothalamic amenorrhea.

PubMed

Podfigurna-Stopa, Agnieszka; Pludowski, Pawel; Jaworski, Maciej; Lorenc, Roman; Genazzani, Andrea R; Meczekalski, Blazej

2012-04-01

Functional hypothalamic amenorrhea (FHA) related to hypoestrogenism and hormonal status may influence skeletal homeostasis and body composition. The study aimed to evaluate hormones concentrations, body composition and bone strength in FHA cases. Total body scans using DXA method (DPX-L, GE Lunar) were performed in a group of 27 women aged 21.8 years ± 3.9 with FHA related to weight loss. References of healthy control subjects were used to calculate Z-scores (age and gender matched), SD-scores (height and gender matched), and SDs-scores (weight and gender matched). Whole skeleton bone mineral content (TBBMC, g) and density (TBBMD, g/cm(2)), lumbar spine (L2-L4) bone mineral density (SBMD; g/cm(2)), lean body mass (LBM, g) and fat mass (FM, g) were investigated. Relative bone strength index was calculated as the TBBMC/LBM ratio. Serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol, testosterone, and prolactin (PRL) concentrations were assayed to characterize hormonal profile of FHA cases. Hormonal evaluation in patients with FHA revealed significantly decreased serum concentrations of gonadotropins and estradiol. Serum LH concentrations were 1.47 ± 0.89 mIU/ml, FSH 4.44 ± 1.94 mIU/ml. Estradiol concentrations in serum were 27.08 ± 13.10 pg/ml. As evidenced by Z-scores, FHA cases had decreased SBMD, TBBMD and TBBMC Z-scores of -1.23 ± 0.90 (p < 0.0001), -0.72 ± 0.86 (p < 0.001), and -0.90 ± 1.40 (p < 0.01), respectively. Reduced FM, LBM and FM/LBM ratio Z-scores of -1.80 ± 2.28 (p < 0.001), -0.59 ± 1.49 (p < 0.05) and -0.74 ± 1.55 (p < 0.05), but not TBBMC/LBM Z-score of -0.54 ± 2.14 (ns) were noted in FHA cases compared with healthy control cases. TBBMC, TBBMD, TBBMC/LBM when BH- or BW-matched were normal as evidenced by SD-scores and SDs-scores. SBMD remained reduced when BH-matched (SD-score = -0.40 ± 0.86; p < 0.05) whereas FM and FM/LBM were lower than expected in healthy, both compared to BH- and BW-dependent references. The length of amenorrhea in months negatively correlated with SBMD Z-score (R = -0.39, p < 0.05), and SD-scores for SBMD (R = -0.48), TBBMD (R = -0.43), TBBMC (R = -0.46) (all p < 0.05) and positively with SDs-scores for FM (R = 0.44, p < 0.05). Patients with FHA were characterized by lower concentrations of serum FSH, LH and estradiol concentrations. Moreover, FHA cases had decreased FM and an imbalanced relationship between BW, FM, and LBM. Despite reduced BMD and BMC, bone strength was not significantly affected by FHA.

24 CFR 266.200 - Eligible projects.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Eligible projects. 266.200 Section... FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Program Requirements § 266.200 Eligible projects. (a) Minimum project size. Projects insured under this part must consist of...

24 CFR 266.200 - Eligible projects.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Eligible projects. 266.200 Section... FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Program Requirements § 266.200 Eligible projects. (a) Minimum project size. Projects insured under this part must consist of...

24 CFR 266.200 - Eligible projects.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Eligible projects. 266.200 Section... FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Program Requirements § 266.200 Eligible projects. (a) Minimum project size. Projects insured under this part must consist of...

24 CFR 266.200 - Eligible projects.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Eligible projects. 266.200 Section... FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Program Requirements § 266.200 Eligible projects. (a) Minimum project size. Projects insured under this part must consist of...

A Multisite Program Evaluation of Families and Schools Together (FAST): Continued Evidence of a Successful Multifamily Community-Based Prevention Program

ERIC Educational Resources Information Center

Crozier, Mary; Rokutani, Laurie; Russett, Jill L.; Godwin, Emilie; Banks, George E.

2010-01-01

Strong school and family ties have long shown success in influencing positive child development and lasting academic success. While a multitude of programs exist to help facilitate the school-family connection, one program in particular, Families and Schools Together, or FAST, stands out as an effective prevention program that is suitable for a…

24 CFR 266.417 - Authority to adjust mortgage insurance amount.

Code of Federal Regulations, 2010 CFR

2010-04-01

... AND OTHER AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Mortgage and Closing Requirements; HUD Endorsement § 266.417 Authority to adjust mortgage...

Polymorphism of the vitamin D3 receptor gene and bone mineral density in girls with functional hypothalamic amenorrhea subjected to oestroprogestagen treatment.

PubMed

Sowińska-Przepiera, Elżbieta; Andrysiak-Mamos, Elżbieta; Syrenicz, Justyna; Jarząbek-Bielecka, Grażyna; Friebe, Zbigniew; Syrenicz, Anhelli

2011-01-01

We investigated whether the vitamin D3 receptor gene (VDR) polymorphism can modulate therapeutic response of functional hypothalamic amenorrhea (FHA) patients to the oestroprogestagen (EP) treatment. The study included 84 FHA girls and 50 controls. FHA patients underwent a four-year sequential EP therapy with 17-β oestradiol (2 mg from the 2(nd) to 25(th) day of the menstrual cycle) and didrogesterone (10 mg from the 16(th) to the 25(th) day). Their hormonal parameters were monitored along with bone turnover marker levels and bone mineral density (BMD). Additionally, the VDR gene BsmI polymorphism was determined. Hormonal therapy was reflected by a substantial improvement of BMD. However, the values of BMD observed after four years of treatment in FHA patients were still significantly lower than baseline bone mineral density determined in the control group (1.007 ± 0.100 vs. 1.141 ± 0.093 g/cm(2), respectively; p < 0.001). No significant effects of the VDR genotype were observed on the dynamics of BMD during consecutive years of hormonal treatment and mean bone mineral density determined after completing the therapy (1.006 ± 0.101 vs. 1.013 ± 0.114 vs. 1.006 ± 0.094 g/cm(2) for BB, bb and Bb genotypes, respectively; p = 0.973). This study did not confirm that VDR polymorphism can modulate therapeutic outcome of FHA girls subjected to the hormonal treatment. Nonetheless, this study confirmed the effectiveness of EP therapy in the simultaneous treatment of menstrual disorders and the normalisation of bone mineral density in FHA patients.

Effect of open-label infusion of an apoA-I-containing particle (CER-001) on RCT and artery wall thickness in patients with FHA[S

PubMed Central

Kootte, Ruud S.; Smits, Loek P.; van der Valk, Fleur M.; Dasseux, Jean-Louis; Keyserling, Constance H.; Barbaras, Ronald; Paolini, John F.; Santos, Raul D.; van Dijk, Theo H.; Dallinga-van Thie, Geesje M.; Nederveen, Aart J.; Mulder, Willem J. M.; Hovingh, G. Kees; Kastelein, John J. P.; Groen, Albert K.; Stroes, Erik S.

2015-01-01

Reverse cholesterol transport (RCT) contributes to the anti-atherogenic effects of HDL. Patients with the orphan disease, familial hypoalphalipoproteinemia (FHA), are characterized by decreased tissue cholesterol removal and an increased atherogenic burden. We performed an open-label uncontrolled proof-of-concept study to evaluate the effect of infusions with a human apoA-I-containing HDL-mimetic particle (CER-001) on RCT and the arterial vessel wall in FHA. Subjects received 20 infusions of CER-001 (8 mg/kg) during 6 months. Efficacy was assessed by measuring (apo)lipoproteins, plasma-mediated cellular cholesterol efflux, fecal sterol excretion (FSE), and carotid artery wall dimension by MRI and artery wall inflammation by 18F-fluorodeoxyglucose-positron emission tomography/computed tomography scans. We included seven FHA patients: HDL-cholesterol (HDL-c), 13.8 [1.8–29.1] mg/dl; apoA-I, 28.7 [7.9–59.1] mg/dl. Following nine infusions in 1 month, apoA-I and HDL-c increased directly after infusion by 27.0 and 16.1 mg/dl (P = 0.018). CER-001 induced a 44% relative increase (P = 0.018) in in vitro cellular cholesterol efflux with a trend toward increased FSE (P = 0.068). After nine infusions of CER-001, carotid mean vessel wall area decreased compared with baseline from 25.0 to 22.8 mm2 (P = 0.043) and target-to-background ratio from 2.04 to 1.81 (P = 0.046). In FHA-subjects, CER-001 stimulates cholesterol mobilization and reduces artery wall dimension and inflammation, supporting further evaluation of CER-001 in FHA patients. PMID:25561459

Effect of open-label infusion of an apoA-I-containing particle (CER-001) on RCT and artery wall thickness in patients with FHA.

PubMed

Kootte, Ruud S; Smits, Loek P; van der Valk, Fleur M; Dasseux, Jean-Louis; Keyserling, Constance H; Barbaras, Ronald; Paolini, John F; Santos, Raul D; van Dijk, Theo H; Dallinga-van Thie, Geesje M; Nederveen, Aart J; Mulder, Willem J M; Hovingh, G Kees; Kastelein, John J P; Groen, Albert K; Stroes, Erik S

2015-03-01

Reverse cholesterol transport (RCT) contributes to the anti-atherogenic effects of HDL. Patients with the orphan disease, familial hypoalphalipoproteinemia (FHA), are characterized by decreased tissue cholesterol removal and an increased atherogenic burden. We performed an open-label uncontrolled proof-of-concept study to evaluate the effect of infusions with a human apoA-I-containing HDL-mimetic particle (CER-001) on RCT and the arterial vessel wall in FHA. Subjects received 20 infusions of CER-001 (8 mg/kg) during 6 months. Efficacy was assessed by measuring (apo)lipoproteins, plasma-mediated cellular cholesterol efflux, fecal sterol excretion (FSE), and carotid artery wall dimension by MRI and artery wall inflammation by (18)F-fluorodeoxyglucose-positron emission tomography/computed tomography scans. We included seven FHA patients: HDL-cholesterol (HDL-c), 13.8 [1.8-29.1] mg/dl; apoA-I, 28.7 [7.9-59.1] mg/dl. Following nine infusions in 1 month, apoA-I and HDL-c increased directly after infusion by 27.0 and 16.1 mg/dl (P = 0.018). CER-001 induced a 44% relative increase (P = 0.018) in in vitro cellular cholesterol efflux with a trend toward increased FSE (P = 0.068). After nine infusions of CER-001, carotid mean vessel wall area decreased compared with baseline from 25.0 to 22.8 mm(2) (P = 0.043) and target-to-background ratio from 2.04 to 1.81 (P = 0.046). In FHA-subjects, CER-001 stimulates cholesterol mobilization and reduces artery wall dimension and inflammation, supporting further evaluation of CER-001 in FHA patients. Copyright © 2015 by the American Society for Biochemistry and Molecular Biology, Inc.

STRONG MILITARY FAMILIES INTERVENTION ENHANCES PARENTING REFLECTIVITY AND REPRESENTATIONS IN FAMILIES WITH YOUNG CHILDREN.

PubMed

Julian, M M; Muzik, M; Kees, M; Valenstein, M; Rosenblum, K L

2018-01-01

Military families face many challenges due to deployment and parental separation, and this can be especially difficult for families with young children. The Strong Military Families (SMF) intervention is for military families with young children, and consists of two versions: the Multifamily Group, and a Home-based psychoeducational written materials program. The Multifamily Group was designed to enhance positive parenting through both educational components and in vivo feedback and support during separations and reunions between parents and children (n = 78 parents). In the present study, we examine parenting reflectivity and mental representations in mothers versus fathers in military families, service members versus civilian spouses/parenting partners, and before versus after participation in the SMF Multifamily Group and Home-based interventions. Parenting reflectivity and mental representations were coded from the Working Model of the Child Interview (WMCI; C.H. Zeanah & D. Benoit, 1995). Results suggest that neither parenting reflectivity nor WMCI typology differs between mothers and fathers in military families, or between service members and civilian parenting partners. Furthermore, there was substantial stability in parenting reflectivity and WMCI typology from baseline to posttest, but participation in the Multifamily Group, relative to Home-based, was associated with improvements in both parenting reflectivity and WMCI ratings from baseline to postintervention. © 2017 Michigan Association for Infant Mental Health.

Reversible Opening of the Blood-Brain Barrier by Anti-Bacterial Antibodies

NASA Astrophysics Data System (ADS)

Tuomanen, Elaine I.; Prasad, Sudha M.; George, Jonathan S.; Hoepelman, Andy I. M.; Ibsen, Per; Heron, Iver; Starzyk, Ruth M.

1993-08-01

The leukocyte adhesion molecule CR3 (CD11b/CD18, Mac-1) promotes leukocyte transmigration into tissues by engaging an unknown cognate ligand on the surface of vascular endothelial cells. Filamentous hemagglutinin (FHA), an adhesin of the bacterium Bordetella pertussis, binds to CR3. We hypothesized that FHA mimics the native ligand for the CR3 integrin on endothelial cells and predicted that anti-FHA antibodies should bind to endothelial cells, interfere with leukocyte recruitment, and induce endothelial permeability. Anti-FHA monoclonal antibodies bound to cerebral microvessels in sections from human brain and upon intravenous injection into rabbits. Antibody binding correlated with the ability to recognize two polypeptides in extracts of human cerebral vessels that were also bound by CD18. In vivo, antibody binding not only interfered with transmigration of leukocytes into cerebrospinal fluid but also induced a dose-dependent reversible increase in blood-brain barrier permeability sufficient to improve delivery of intravenously administered therapeutic agents to brain parenchyma.

Simulating indoor concentrations of NO(2) and PM(2.5) in multifamily housing for use in health-based intervention modeling.

PubMed

Fabian, P; Adamkiewicz, G; Levy, J I

2012-02-01

Residents of low-income multifamily housing can have elevated exposures to multiple environmental pollutants known to influence asthma. Simulation models can characterize the health implications of changing indoor concentrations, but quantifying the influence of interventions on concentrations is challenging given complex airflow and source characteristics. In this study, we simulated concentrations in a prototype multifamily building using CONTAM, a multizone airflow and contaminant transport program. Contaminants modeled included PM(2.5) and NO(2) , and parameters included stove use, presence and operability of exhaust fans, smoking, unit level, and building leakiness. We developed regression models to explain variability in CONTAM outputs for individual sources, in a manner that could be utilized in simulation modeling of health outcomes. To evaluate our models, we generated a database of 1000 simulated households with characteristics consistent with Boston public housing developments and residents and compared the predicted levels of NO(2) and PM(2.5) and their correlates with the literature. Our analyses demonstrated that CONTAM outputs could be readily explained by available parameters (R(2) between 0.89 and 0.98 across models), but that one-compartment box models would mischaracterize concentrations and source contributions. Our study quantifies the key drivers for indoor concentrations in multifamily housing and helps to identify opportunities for interventions. Many low-income urban asthmatics live in multifamily housing that may be amenable to ventilation-related interventions such as weatherization or air sealing, wall and ceiling hole repairs, and exhaust fan installation or repair, but such interventions must be designed carefully given their cost and their offsetting effects on energy savings as well as indoor and outdoor pollutants. We developed models to take into account the complex behavior of airflow patterns in multifamily buildings, which can be used to identify and evaluate environmental and non-environmental interventions targeting indoor air pollutants which can trigger asthma exacerbations. © 2011 John Wiley & Sons A/S.

75 FR 8391 - Assisted Living Conversion Program (ALCP) and Emergency Capital Repair Program (ECRP)

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-24

... submitted to the Office of Management and Budget (OMB) for review, as required by the Paperwork Reduction... Conversion Program (ALCP) provides funding for the physical costs of converting some or all the units of an...) provides funding for the physical costs of converting some or all the units of an eligible multifamily...

24 CFR 266.10 - Allocations of assistance and credit subsidy.

Code of Federal Regulations, 2010 CFR

2010-04-01

... AND OTHER AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS General Provisions § 266.10 Allocations of assistance and credit subsidy. (a) Notice of...

Housing Assistance Programs and Adult Health in the United States

PubMed Central

Fenelon, Andrew; Mayne, Patrick; Simon, Alan E.; Rossen, Lauren M.; Helms, Veronica; Lloyd, Patricia; Sperling, Jon; Steffen, Barry L.

2017-01-01

Objectives To examine whether access to housing assistance is associated with better health among low-income adults. Methods We used National Health Interview Survey data (1999–2012) linked to US Department of Housing and Urban Development (HUD) administrative records (1999–2014) to examine differences in reported fair or poor health and psychological distress. We used multivariable models to compare those currently receiving HUD housing assistance (public housing, housing choice vouchers, and multifamily housing) with those who will receive housing assistance within 2 years (the average duration of HUD waitlists) to account for selection into HUD assistance. Results We found reduced odds of fair or poor health for current public housing (odds ratio [OR] = 0.77; 95% confidence interval [CI] = 0.57, 0.97) and multifamily housing (OR = 0.75; 95% CI = 0.60, 0.95) residents compared with future residents. Public housing residents also had reduced odds of psychological distress (OR = 0.59; 95% CI = 0.40, 0.86). These differences were not mediated by neighborhood-level characteristics, and we did not find any health benefits for current housing choice voucher recipients. Conclusions Housing assistance is associated with improved health and psychological well-being for individuals entering public housing and multifamily housing programs. PMID:28207335

Housing Assistance Programs and Adult Health in the United States.

PubMed

Fenelon, Andrew; Mayne, Patrick; Simon, Alan E; Rossen, Lauren M; Helms, Veronica; Lloyd, Patricia; Sperling, Jon; Steffen, Barry L

2017-04-01

To examine whether access to housing assistance is associated with better health among low-income adults. We used National Health Interview Survey data (1999-2012) linked to US Department of Housing and Urban Development (HUD) administrative records (1999-2014) to examine differences in reported fair or poor health and psychological distress. We used multivariable models to compare those currently receiving HUD housing assistance (public housing, housing choice vouchers, and multifamily housing) with those who will receive housing assistance within 2 years (the average duration of HUD waitlists) to account for selection into HUD assistance. We found reduced odds of fair or poor health for current public housing (odds ratio [OR] = 0.77; 95% confidence interval [CI] = 0.57, 0.97) and multifamily housing (OR = 0.75; 95% CI = 0.60, 0.95) residents compared with future residents. Public housing residents also had reduced odds of psychological distress (OR = 0.59; 95% CI = 0.40, 0.86). These differences were not mediated by neighborhood-level characteristics, and we did not find any health benefits for current housing choice voucher recipients. Housing assistance is associated with improved health and psychological well-being for individuals entering public housing and multifamily housing programs.

75 FR 4271 - Refinement of Income and Rent Determination Requirements in Public and Assisted Housing Programs...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-27

... 2501-AD48 Refinement of Income and Rent Determination Requirements in Public and Assisted Housing Programs: Implementation of the Enterprise Income Verification System; Withdrawal of Rescinded Regulatory... use of the Enterprise Income Verification (EIV) system by public housing agencies and multifamily...

24 CFR 266.310 - Insurance of advances or insurance upon completion; applicability of requirements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Processing, Development, and Approval § 266.310 Insurance of... projects involving new construction or substantial rehabilitation. Existing projects without the need for...

Changing What You Know and Do: The Parent-Child Psychotherapy Program

ERIC Educational Resources Information Center

Kaplan, Betty Ann; Venza, James

2011-01-01

The Parent-Child Psychotherapy Program (PPP) is a multifamily group therapy intervention for parents and young children at high risk for intergenerational patterns of neglect, abuse, and disorganized attachment. A "developmental and experiential model" that incorporates principles of attachment theory, the PPP addresses parent and child needs…

24 CFR 27.3 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... NONJUDICIAL FORECLOSURE OF MULTIFAMILY AND SINGLE FAMILY MORTGAGES Nonjudicial Foreclosure of Multifamily...: General Counsel means the General Counsel of the Department of Housing and Urban Development; Multifamily... Housing Act. The definition of multifamily mortgage also includes a mortgage taken by the Secretary in...

24 CFR 290.23 - Rebuilding.

Code of Federal Regulations, 2011 CFR

2011-04-01

... HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.23 Rebuilding. HUD may provide project-based assistance to support the rebuilding of a HUD-owned multifamily housing project only. The required determination that...

24 CFR 290.23 - Rebuilding.

Code of Federal Regulations, 2012 CFR

2012-04-01

... HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.23 Rebuilding. HUD may provide project-based assistance to support the rebuilding of a HUD-owned multifamily housing project only. The required determination that...

77 FR 32129 - Notice of Proposed Information Collection; Comment Request: Multifamily Contractor's/Mortgagor's...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-31

... Information Collection; Comment Request: Multifamily Contractor's/Mortgagor's Cost Breakdowns and..., Technical Support, Office of Multifamily Housing Development, Department of Housing and Urban Development... also lists the following information: Title of Proposal: Multifamily Contractor's/Mortgagor's Cost...

24 CFR 27.3 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-04-01

... NONJUDICIAL FORECLOSURE OF MULTIFAMILY AND SINGLE FAMILY MORTGAGES Nonjudicial Foreclosure of Multifamily...: General Counsel means the General Counsel of the Department of Housing and Urban Development; Multifamily... Housing Act. The definition of multifamily mortgage also includes a mortgage taken by the Secretary in...

24 CFR 27.3 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-04-01

... NONJUDICIAL FORECLOSURE OF MULTIFAMILY AND SINGLE FAMILY MORTGAGES Nonjudicial Foreclosure of Multifamily...: General Counsel means the General Counsel of the Department of Housing and Urban Development; Multifamily... Housing Act. The definition of multifamily mortgage also includes a mortgage taken by the Secretary in...

24 CFR 290.23 - Rebuilding.

Code of Federal Regulations, 2014 CFR

2014-04-01

... HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.23 Rebuilding. HUD may provide project-based assistance to support the rebuilding of a HUD-owned multifamily housing project only. The required determination that...

24 CFR 27.3 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... NONJUDICIAL FORECLOSURE OF MULTIFAMILY AND SINGLE FAMILY MORTGAGES Nonjudicial Foreclosure of Multifamily...: General Counsel means the General Counsel of the Department of Housing and Urban Development; Multifamily... Housing Act. The definition of multifamily mortgage also includes a mortgage taken by the Secretary in...

24 CFR 290.23 - Rebuilding.

Code of Federal Regulations, 2010 CFR

2010-04-01

... HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.23 Rebuilding. HUD may provide project-based assistance to support the rebuilding of a HUD-owned multifamily housing project only. The required determination that...

77 FR 15116 - Notice of Proposed Information Collection: Comment Request; FHA-Insured Mortgage Loan Servicing...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-14

... Information Collection: Comment Request; FHA- Insured Mortgage Loan Servicing for Performing Loans; MIP Processing, Escrow Administration, Customer Service, Servicing Fees and 235 Loans AGENCY: Office of the Assistant Secretary for Housing, HUD. ACTION: Notice. SUMMARY: The proposed information collection...

76 FR 22120 - Credit Watch Termination Initiative; Termination of Origination Approval Agreements

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-20

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR- 5511-N-01] Credit Watch Termination Initiative; Termination of Origination Approval Agreements AGENCY: Office of the Assistant Secretary for... (FHA) against HUD-approved mortgagees through the FHA Credit Watch Termination Initiative. This notice...

75 FR 67387 - Credit Watch Termination Initiative Termination of Origination Approval Agreements

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-02

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-4211-N-05] Credit Watch Termination Initiative Termination of Origination Approval Agreements AGENCY: Office of the Assistant Secretary for... (FHA) against HUD-approved mortgagees through the FHA Credit Watch Termination Initiative. This notice...

77 FR 38818 - Credit Watch Termination Initiative; Termination of Origination Approval Agreements

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-29

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5644-N-01] Credit Watch Termination Initiative; Termination of Origination Approval Agreements AGENCY: Office of the Assistant Secretary for... (FHA) against HUD-approved mortgagees through the FHA Credit Watch Termination Initiative. This notice...

76 FR 38406 - Credit Watch Termination Initiative; Termination of Origination Approval Agreements

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-30

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5511-N-03] Credit Watch Termination Initiative; Termination of Origination Approval Agreements AGENCY: Office of the Assistant Secretary for... (FHA) against HUD-approved mortgagees through the FHA Credit Watch Termination Initiative. This notice...

76 FR 4126 - Credit Watch Termination Initiative Termination of Origination Approval Agreements

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-24

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR- 5411-N-07] Credit Watch Termination Initiative Termination of Origination Approval Agreements AGENCY: Office of the Assistant Secretary for... (FHA) against HUD-approved mortgagees through the FHA Credit Watch Termination Initiative. This notice...

77 FR 5263 - Credit Watch Termination Initiative Termination of Origination Approval Agreements

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-02

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5511-N-06] Credit Watch Termination Initiative Termination of Origination Approval Agreements AGENCY: Office of the Assistant Secretary for... (FHA) against HUD-approved mortgagees through the FHA Credit Watch Termination Initiative. This notice...

75 FR 61164 - Credit Watch Termination Initiative Termination of Origination Approval Agreements

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-04

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5411-N-03] Credit Watch Termination Initiative Termination of Origination Approval Agreements AGENCY: Office of the Assistant Secretary for... (FHA) against HUD-approved mortgagees through the FHA Credit Watch Termination Initiative. This notice...

75 FR 4835 - Notice of Proposed Information Collection: Comment Request; FHA-Insured Mortgage Loan Servicing...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-29

... Information Collection: Comment Request; FHA- Insured Mortgage Loan Servicing Property Physical Inspection.... This Notice also lists the following information: Title of Proposal: MF Uniform Physical Inspection... inspected regularly. Entities responsible for conducting physical inspections of the properties are HUD, the...

24 CFR 266.628 - Initial claim payments.

Code of Federal Regulations, 2010 CFR

2010-04-01

... HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Contract... as of the date of default, plus interest at the mortgage note rate from date of default to date of...

24 CFR 266.616 - Transfer of partial interest under participation agreement.

Code of Federal Regulations, 2010 CFR

2010-04-01

... HOUSING ACT AND OTHER AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Contract Rights and Obligations Assignments § 266.616 Transfer of partial interest...

Characterization of the APLF FHA–XRCC1 phosphopeptide interaction and its structural and functional implications

PubMed Central

Kim, Kyungmin; Pedersen, Lars C.; Kirby, Thomas W.; DeRose, Eugene F.

2017-01-01

Abstract Aprataxin and PNKP-like factor (APLF) is a DNA repair factor containing a forkhead-associated (FHA) domain that supports binding to the phosphorylated FHA domain binding motifs (FBMs) in XRCC1 and XRCC4. We have characterized the interaction of the APLF FHA domain with phosphorylated XRCC1 peptides using crystallographic, NMR, and fluorescence polarization studies. The FHA–FBM interactions exhibit significant pH dependence in the physiological range as a consequence of the atypically high pK values of the phosphoserine and phosphothreonine residues and the preference for a dianionic charge state of FHA-bound pThr. These high pK values are characteristic of the polyanionic peptides typically produced by CK2 phosphorylation. Binding affinity is greatly enhanced by residues flanking the crystallographically-defined recognition motif, apparently as a consequence of non-specific electrostatic interactions, supporting the role of XRCC1 in nuclear cotransport of APLF. The FHA domain-dependent interaction of XRCC1 with APLF joins repair scaffolds that support single-strand break repair and non-homologous end joining (NHEJ). It is suggested that for double-strand DNA breaks that have initially formed a complex with PARP1 and its binding partner XRCC1, this interaction acts as a backup attempt to intercept the more error-prone alternative NHEJ repair pathway by recruiting Ku and associated NHEJ factors. PMID:29059378

Comparison between pulsatile GnRH therapy and gonadotropins for ovulation induction in women with both functional hypothalamic amenorrhea and polycystic ovarian morphology.

PubMed

Dumont, Agathe; Dewailly, Didier; Plouvier, Pauline; Catteau-Jonard, Sophie; Robin, Geoffroy

2016-12-01

Ovulation induction in patients having both functional hypothalamic amenorrhea (FHA) and polycystic ovarian morphology (PCOM) has been less studied in the literature. As results remain contradictory, no recommendations have yet been established. To compare pulsatile GnRH therapy versus gonadotropins for ovulation induction in "FHA-PCOM" patients and to determine if one treatment strikes as superior to the other. A 12-year retrospective study, comparing 55 "FHA-PCOM" patients, treated either with GnRH therapy (38 patients, 93 cycles) or with gonadotropins (17 patients, 53 cycles). Both groups were similar, defined by low serum LH and E2 levels, low BMI, excessive follicle number per ovary and/or high serum AMH level. Ovulation rates were significantly lower with gonadotropins (56.6% versus 78.6%, p = 0.005), with more cancellation and ovarian hyper-responses (14% versus 34% per initiated cycle, p < 0.005). Pregnancy rates were significantly higher with GnRH therapy, whether per initiated cycle (26.9% versus 7.6%, p = 0.005) or per patient (65.8% versus 23.5%, p = 0.007). In our study, GnRH therapy was more successful and safer than gonadotropins, for ovulation induction in "FHA-PCOM" patients. If results were confirmed by prospective studies, it could become a first-line treatment for this population, just as it is for FHA women without PCOM.

DNA Replication Checkpoint Signaling Depends on a Rad53–Dbf4 N-Terminal Interaction in Saccharomyces cerevisiae

PubMed Central

Chen, Ying-Chou; Kenworthy, Jessica; Gabrielse, Carrie; Hänni, Christine; Zegerman, Philip; Weinreich, Michael

2013-01-01

Dbf4-dependent kinase (DDK) and cyclin-dependent kinase (CDK) are essential to initiate DNA replication at individual origins. During replication stress, the S-phase checkpoint inhibits the DDK- and CDK-dependent activation of late replication origins. Rad53 kinase is a central effector of the replication checkpoint and both binds to and phosphorylates Dbf4 to prevent late-origin firing. The molecular basis for the Rad53–Dbf4 physical interaction is not clear but occurs through the Dbf4 N terminus. Here we found that both Rad53 FHA1 and FHA2 domains, which specifically recognize phospho-threonine (pT), interacted with Dbf4 through an N-terminal sequence and an adjacent BRCT domain. Purified Rad53 FHA1 domain (but not FHA2) bound to a pT Dbf4 peptide in vitro, suggesting a possible phospho-threonine-dependent interaction between FHA1 and Dbf4. The Dbf4–Rad53 interaction is governed by multiple contacts that are separable from the Cdc5- and Msa1-binding sites in the Dbf4 N terminus. Importantly, abrogation of the Rad53–Dbf4 physical interaction blocked Dbf4 phosphorylation and allowed late-origin firing during replication checkpoint activation. This indicated that Rad53 must stably bind to Dbf4 to regulate its activity. PMID:23564203

DNA replication checkpoint signaling depends on a Rad53-Dbf4 N-terminal interaction in Saccharomyces cerevisiae.

PubMed

Chen, Ying-Chou; Kenworthy, Jessica; Gabrielse, Carrie; Hänni, Christine; Zegerman, Philip; Weinreich, Michael

2013-06-01

Dbf4-dependent kinase (DDK) and cyclin-dependent kinase (CDK) are essential to initiate DNA replication at individual origins. During replication stress, the S-phase checkpoint inhibits the DDK- and CDK-dependent activation of late replication origins. Rad53 kinase is a central effector of the replication checkpoint and both binds to and phosphorylates Dbf4 to prevent late-origin firing. The molecular basis for the Rad53-Dbf4 physical interaction is not clear but occurs through the Dbf4 N terminus. Here we found that both Rad53 FHA1 and FHA2 domains, which specifically recognize phospho-threonine (pT), interacted with Dbf4 through an N-terminal sequence and an adjacent BRCT domain. Purified Rad53 FHA1 domain (but not FHA2) bound to a pT Dbf4 peptide in vitro, suggesting a possible phospho-threonine-dependent interaction between FHA1 and Dbf4. The Dbf4-Rad53 interaction is governed by multiple contacts that are separable from the Cdc5- and Msa1-binding sites in the Dbf4 N terminus. Importantly, abrogation of the Rad53-Dbf4 physical interaction blocked Dbf4 phosphorylation and allowed late-origin firing during replication checkpoint activation. This indicated that Rad53 must stably bind to Dbf4 to regulate its activity.

78 FR 20351 - Notice of Proposed Information Collection; Comment Request: Application for Multifamily Project...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-04

... Information Collection; Comment Request: Application for Multifamily Project Mortgage Insurance AGENCY: Office...). FOR FURTHER INFORMATION CONTACT: Ted Toon, Director, Office of Multifamily Development, Department of... following information: Title of Proposal: Application for Multifamily Project Mortgage Insurance. OMB...

24 CFR 290.1 - Applicability.

Code of Federal Regulations, 2010 CFR

2010-04-01

... respect to the disposition of multifamily projects under subpart A, HUD may follow any other method of... HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.1 Applicability. The requirements of this part supplement the...

75 FR 62410 - Notice of Proposed Information Collection: Comment Request; The Multifamily Accelerated...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-08

... Information Collection: Comment Request; The Multifamily Accelerated Processing Guide AGENCY: Office of the... also lists the following information: Title of Proposal: Multifamily Accelerated Processing Guide (MAP...-0541. Description of the need for the information and proposed use: Multifamily Accelerated Processing...

24 CFR 200.227 - Multifamily Participation Review Committee.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Multifamily Participation Review... Requirements Previous Participation Review and Clearance Procedure § 200.227 Multifamily Participation Review... Insured Multifamily Housing Development; the Director of the Office of the Elderly and Assisted Housing...

24 CFR 290.15 - Disposition plan.

Code of Federal Regulations, 2014 CFR

2014-04-01

... DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.15 Disposition plan. (a) In general. Before disposing of a HUD-owned multifamily housing project, HUD will develop an initial and a final disposition plan...

24 CFR 200.227 - Multifamily Participation Review Committee.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Multifamily Participation Review... Requirements Previous Participation Review and Clearance Procedure § 200.227 Multifamily Participation Review... Insured Multifamily Housing Development; the Director of the Office of the Elderly and Assisted Housing...

24 CFR 290.15 - Disposition plan.

Code of Federal Regulations, 2012 CFR

2012-04-01

... DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.15 Disposition plan. (a) In general. Before disposing of a HUD-owned multifamily housing project, HUD will develop an initial and a final disposition plan...

24 CFR 200.227 - Multifamily Participation Review Committee.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Multifamily Participation Review... Requirements Previous Participation Review and Clearance Procedure § 200.227 Multifamily Participation Review... Insured Multifamily Housing Development; the Director of the Office of the Elderly and Assisted Housing...

24 CFR 290.15 - Disposition plan.

Code of Federal Regulations, 2011 CFR

2011-04-01

... DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.15 Disposition plan. (a) In general. Before disposing of a HUD-owned multifamily housing project, HUD will develop an initial and a final disposition plan...

77 FR 70179 - Notice of HUD-Held Multifamily and Healthcare Loan Sale

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-23

... Multifamily and Healthcare Loan Sale AGENCY: Office of the Assistant Secretary for Housing--Federal Housing...'s intention to sell certain unsubsidized multifamily and healthcare mortgage loans, without Federal... certain unsubsidized mortgage loans (Mortgage Loans) secured by multifamily and healthcare properties...

75 FR 12775 - Notice of HUD-Held Multifamily and Healthcare Loan Sale

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-17

...-Held Multifamily and Healthcare Loan Sale AGENCY: Office of the Assistant Secretary for Housing... announces HUD's intention to sell certain unsubsidized multifamily and healthcare mortgage loans, without...) secured by multifamily and healthcare properties located throughout the United States. The Mortgage Loans...

76 FR 68773 - Notice of Proposed Information Collection: Comment Request; FHA-Insured Mortgage Loan Servicing...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-07

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5484-N-34] Notice of Proposed Information Collection: Comment Request; FHA- Insured Mortgage Loan Servicing Involving the Claims and Conveyance Process, Property Inspection/Preservation AGENCY: Office of the Assistant Secretary for Housing...

24 CFR 202.5 - General approval standards.

Code of Federal Regulations, 2011 CFR

2011-04-01

... years from the date that the materials are circulated or used to advertise. (3) Non-FHA-approved entities. A lender or mortgagee that accepts a loan application from a non-FHA-approved entity must confirm..., including, but not limited to, mergers, terminations, name, location, control of ownership, and character of...

24 CFR 202.5 - General approval standards.

Code of Federal Regulations, 2013 CFR

2013-04-01

... years from the date that the materials are circulated or used to advertise. (3) Non-FHA-approved entities. A lender or mortgagee that accepts a loan application from a non-FHA-approved entity must confirm..., including, but not limited to, mergers, terminations, name, location, control of ownership, and character of...

24 CFR 202.5 - General approval standards.

Code of Federal Regulations, 2012 CFR

2012-04-01

... years from the date that the materials are circulated or used to advertise. (3) Non-FHA-approved entities. A lender or mortgagee that accepts a loan application from a non-FHA-approved entity must confirm..., including, but not limited to, mergers, terminations, name, location, control of ownership, and character of...

76 FR 22119 - Credit Watch Termination Initiative; Termination of Direct Endorsement (DE) Approval

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-20

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5511-N-02] Credit Watch Termination Initiative; Termination of Direct Endorsement (DE) Approval AGENCY: Office of the Assistant Secretary for... (FHA) against HUD-approved mortgagees through the FHA Credit Watch Termination Initiative. This notice...

76 FR 53148 - Credit Watch Termination Initiative; Termination of Direct Endorsement (DE) Approval

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-25

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5511-N-05] Credit Watch Termination Initiative; Termination of Direct Endorsement (DE) Approval AGENCY: Office of the Assistant Secretary for... (FHA) against HUD-approved mortgagees through the FHA Credit Watch Termination Initiative. This notice...

77 FR 5262 - Credit Watch Termination Initiative Termination of Direct Endorsement (DE) Approval

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-02

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5511-N-07] Credit Watch Termination Initiative Termination of Direct Endorsement (DE) Approval AGENCY: Office of the Assistant Secretary for... (FHA) against HUD-approved mortgagees through the FHA Credit Watch Termination Initiative. This notice...

77 FR 38817 - Credit Watch Termination Initiative; Termination of Direct Endorsement (DE) Approval

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-29

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5644-N-02] Credit Watch Termination Initiative; Termination of Direct Endorsement (DE) Approval AGENCY: Office of the Assistant Secretary for... (FHA) against HUD-approved mortgagees through the FHA Credit Watch Termination Initiative. This notice...

76 FR 38407 - Credit Watch Termination Initiative; Termination of Direct Endorsement (DE) Approval

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-30

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5511-N-04] Credit Watch Termination Initiative; Termination of Direct Endorsement (DE) Approval AGENCY: Office of the Assistant Secretary for... (FHA) against HUD-approved mortgagees through the FHA Credit Watch Termination Initiative. This notice...

75 FR 61165 - Credit Watch Termination Initiative Termination of Direct Endorsement (DE) Approval

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-04

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5411-N-04] Credit Watch Termination Initiative Termination of Direct Endorsement (DE) Approval AGENCY: Office of the Assistant Secretary for... (FHA) against HUD-approved mortgagees through the FHA Credit Watch Termination Initiative. This notice...

76 FR 4364 - Credit Watch Termination Initiative; Termination of Direct Endorsement (DE) Approval

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-25

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5411-N-08] Credit Watch Termination Initiative; Termination of Direct Endorsement (DE) Approval AGENCY: Office of the Assistant Secretary for... (FHA) against HUD-approved mortgagees through the FHA Credit Watch Termination Initiative. This notice...

75 FR 67388 - Credit Watch Termination Initiative; Termination of Direct Endorsement (DE) Approval

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-02

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5411-N-06] Credit Watch Termination Initiative; Termination of Direct Endorsement (DE) Approval AGENCY: Office of the Assistant Secretary for... (FHA) against HUD-approved mortgagees through the FHA Credit Watch Termination Initiative. This notice...

FHA/HERO and the Older Generation.

ERIC Educational Resources Information Center

Mower, Pauline G., Ed.

The booklet describes a sampling of projects and activities carried out by Future Homemakers of America (FHA) and Home Economics Related Occupations (HERO) chapters to indicate how they are concerned for, working with, and learning from older citizens in their respective communities. Projects range from a simple act of friendship to learning…

78 FR 16702 - Notice of Proposed Information Collection: Comment Request FHA-Insured Mortgage Loan Servicing...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-18

... Information Collection: Comment Request FHA- Insured Mortgage Loan Servicing Property Physical Inspection... also lists the following information: Title of Proposal: MF Uniform Physical Inspection Reporting.... Entities responsible for conducting physical inspections of the properties are HUD, the lender or the owner...

76 FR 41441 - Federal Housing Administration (FHA) Appraiser Roster: Appraiser Qualifications for Placement on...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-14

... the FHA Appraiser Roster by replacing the obsolete references to the Credit Alert Interactive Voice Response System with references to its successor, the online-based Credit Alert Verification Reporting...'s Limited Denial of Participation list, or in HUD's Credit Alert Interactive Voice Response System...

75 FR 7513 - Notice of Proposed Information Collection: Comment Request; FHA TOTAL (Technology Open to...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-19

... Information Collection: Comment Request; FHA TOTAL (Technology Open to Approved Lenders) Mortgage Scorecard... information collection requirement described below will be submitted to the Office of Management and Budget...-mail [email protected] or telephone (202) 402-8048 or the number for the Federal Information...

78 FR 24226 - Notice of Proposed Information Collection: Comment Request; FHA TOTAL (Technology Open to...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-24

... Information Collection: Comment Request; FHA TOTAL (Technology Open to Approved Lenders) Mortgage Scorecard... proposed information collection requirement described below will be submitted to the Office of Management... Information Service (1-800-877-8339). FOR FURTHER INFORMATION CONTACT: Karin B. Hill, Director, Office of...

77 FR 51465 - Federal Housing Administration: Strengthening Risk Management Through Responsible FHA-Approved...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-24

.... FR-5622-F-01] RIN 2502-AJ13 Federal Housing Administration: Strengthening Risk Management Through... strengthen the risk management practices of the Federal Housing Administration (FHA), HUD published a final... enforce its risk management regulations. DATES: Effective Date: September 24, 2012. FOR FURTHER...

24 CFR 290.30 - General.

Code of Federal Regulations, 2014 CFR

2014-04-01

... HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Sale of HUD-Held Multifamily Mortgages § 290.30 General. (a) Except as otherwise provided in § 290.31(a)(2), HUD will sell HUD-held multifamily mortgages on a competitive basis. HUD retains full discretion...

24 CFR 290.30 - General.

Code of Federal Regulations, 2010 CFR

2010-04-01

... HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Sale of HUD-Held Multifamily Mortgages § 290.30 General. (a) Except as otherwise provided in § 290.31(a)(2), HUD will sell HUD-held multifamily mortgages on a competitive basis. HUD retains full discretion...

24 CFR 290.1 - Applicability.

Code of Federal Regulations, 2011 CFR

2011-04-01

... HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.1 Applicability. The requirements of this part supplement the requirements of 12 U.S.C. 1701z-11 for the management and disposition of multifamily housing projects and the...

24 CFR 200.224 - Multifamily Participation Review Committee and Participation Control Officer.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Multifamily Participation Review... § 200.224 Multifamily Participation Review Committee and Participation Control Officer. The membership and authority of the Multifamily Participation Review Committee (hereinafter referred to as the Review...

24 CFR 290.30 - General.

Code of Federal Regulations, 2012 CFR

2012-04-01

... HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Sale of HUD-Held Multifamily Mortgages § 290.30 General. (a) Except as otherwise provided in § 290.31(a)(2), HUD will sell HUD-held multifamily mortgages on a competitive basis. HUD retains full discretion...

24 CFR 200.224 - Multifamily Participation Review Committee and Participation Control Officer.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Multifamily Participation Review... § 200.224 Multifamily Participation Review Committee and Participation Control Officer. The membership and authority of the Multifamily Participation Review Committee (hereinafter referred to as the Review...

24 CFR 200.224 - Multifamily Participation Review Committee and Participation Control Officer.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Multifamily Participation Review... § 200.224 Multifamily Participation Review Committee and Participation Control Officer. The membership and authority of the Multifamily Participation Review Committee (hereinafter referred to as the Review...

24 CFR 290.1 - Applicability.

Code of Federal Regulations, 2014 CFR

2014-04-01

... HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.1 Applicability. The requirements of this part supplement the requirements of 12 U.S.C. 1701z-11 for the management and disposition of multifamily housing projects and the...

24 CFR 200.224 - Multifamily Participation Review Committee and Participation Control Officer.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Multifamily Participation Review... § 200.224 Multifamily Participation Review Committee and Participation Control Officer. The membership and authority of the Multifamily Participation Review Committee (hereinafter referred to as the Review...

24 CFR 290.1 - Applicability.

Code of Federal Regulations, 2012 CFR

2012-04-01

... HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.1 Applicability. The requirements of this part supplement the requirements of 12 U.S.C. 1701z-11 for the management and disposition of multifamily housing projects and the...

77 FR 37917 - Notice of Proposed Information Collection: Comment Request; Multifamily Housing Mortgage and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-25

... Information Collection: Comment Request; Multifamily Housing Mortgage and Housing Assistance Restructuring.... This Notice also lists the following information: Title of Proposal: Multifamily Housing Mortgage and... the Multifamily Assisted Housing Reform and Affordability Act of 1997 as extended by the Market to...

24 CFR 290.30 - General.

Code of Federal Regulations, 2011 CFR

2011-04-01

... HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Sale of HUD-Held Multifamily Mortgages § 290.30 General. (a) Except as otherwise provided in § 290.31(a)(2), HUD will sell HUD-held multifamily mortgages on a competitive basis. HUD retains full discretion...

76 FR 5188 - Notice of Proposed Information Collection: Comment Request; Application for Multifamily Project...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-28

... Information Collection: Comment Request; Application for Multifamily Project Mortgage Insurance AGENCY: Office... Service (1-800-877-8339). FOR FURTHER INFORMATION CONTACT: Joyce Allen, Director, Office of Multifamily...: Application for Multifamily Project Mortgage Insurance. OMB Control Number, if applicable: 2502-0029...

24 CFR 266.622 - Notice and date of termination by the Commissioner.

Code of Federal Regulations, 2010 CFR

2010-04-01

... HOUSING ACT AND OTHER AUTHORITIES HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Contract Rights and Obligations Termination § 266.622 Notice and date of termination...

24 CFR 200.925a - Multifamily and care-type minimum property standards.

Code of Federal Regulations, 2013 CFR

2013-04-01

... Standards § 200.925a Multifamily and care-type minimum property standards. (a) Construction standards. Multifamily or care-type properties shall comply with the minimum property standards contained in the handbook.... If the developer or other interested party so chooses, then the multifamily or care-type property...

24 CFR 200.925a - Multifamily and care-type minimum property standards.

Code of Federal Regulations, 2012 CFR

2012-04-01

... Standards § 200.925a Multifamily and care-type minimum property standards. (a) Construction standards. Multifamily or care-type properties shall comply with the minimum property standards contained in the handbook.... If the developer or other interested party so chooses, then the multifamily or care-type property...

24 CFR 200.925a - Multifamily and care-type minimum property standards.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Standards § 200.925a Multifamily and care-type minimum property standards. (a) Construction standards. Multifamily or care-type properties shall comply with the minimum property standards contained in the handbook.... If the developer or other interested party so chooses, then the multifamily or care-type property...

24 CFR 200.925a - Multifamily and care-type minimum property standards.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Standards § 200.925a Multifamily and care-type minimum property standards. (a) Construction standards. Multifamily or care-type properties shall comply with the minimum property standards contained in the handbook.... If the developer or other interested party so chooses, then the multifamily or care-type property...

24 CFR 27.1 - Purpose.

Code of Federal Regulations, 2011 CFR

2011-04-01

... FORECLOSURE OF MULTIFAMILY AND SINGLE FAMILY MORTGAGES Nonjudicial Foreclosure of Multifamily Mortgages § 27.1... Multifamily Mortgage Foreclosure Act of 1981 (the Act) (12 U.S.C. 3701-3717), that clarify, or are in addition... multifamily mortgages. Under a delegation of authority published on February 5, 1982 (47 FR 5468), the...

24 CFR 290.19 - Restrictions concerning nondiscrimination against Section 8 certificate holders and voucher holders.

Code of Federal Regulations, 2011 CFR

2011-04-01

... PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.19 Restrictions concerning nondiscrimination against Section 8 certificate holders and voucher holders. The purchaser of any multifamily housing project shall not refuse unreasonably to...

24 CFR 290.19 - Restrictions concerning nondiscrimination against Section 8 certificate holders and voucher holders.

Code of Federal Regulations, 2014 CFR

2014-04-01

... PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.19 Restrictions concerning nondiscrimination against Section 8 certificate holders and voucher holders. The purchaser of any multifamily housing project shall not refuse unreasonably to...

12 CFR 1282.13 - Multifamily special affordable housing goal and subgoal.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 12 Banks and Banking 9 2012-01-01 2012-01-01 false Multifamily special affordable housing goal and... MISSION ENTERPRISE HOUSING GOALS AND MISSION Housing Goals § 1282.13 Multifamily special affordable housing goal and subgoal. (a) Multifamily housing goal and subgoal. An Enterprise shall be in compliance...

24 CFR 290.19 - Restrictions concerning nondiscrimination against Section 8 certificate holders and voucher holders.

Code of Federal Regulations, 2010 CFR

2010-04-01

... PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.19 Restrictions concerning nondiscrimination against Section 8 certificate holders and voucher holders. The purchaser of any multifamily housing project shall not refuse unreasonably to...

24 CFR 27.1 - Purpose.

Code of Federal Regulations, 2012 CFR

2012-04-01

... FORECLOSURE OF MULTIFAMILY AND SINGLE FAMILY MORTGAGES Nonjudicial Foreclosure of Multifamily Mortgages § 27.1... Multifamily Mortgage Foreclosure Act of 1981 (the Act) (12 U.S.C. 3701-3717), that clarify, or are in addition... multifamily mortgages. Under a delegation of authority published on February 5, 1982 (47 FR 5468), the...

24 CFR 290.27 - Up-front grants and loans.

Code of Federal Regulations, 2014 CFR

2014-04-01

... URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.27 Up-front grants and loans. (a) General. HUD... development costs as part of the disposition of a multifamily housing project that is HUD-owned, upon making a...

78 FR 16701 - Notice of Proposed Information Collection: Comment Request Multifamily Default Status Report

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-18

... Information Collection: Comment Request Multifamily Default Status Report AGENCY: Office of the Assistant... Multifamily Asset Management, Department of Housing and Urban Development, 451 7th Street SW., Washington, DC... Proposal: Multifamily Default Status Report. OMB Control Number, if applicable: 2502-0041. Description of...

24 CFR 290.19 - Restrictions concerning nondiscrimination against Section 8 certificate holders and voucher holders.

Code of Federal Regulations, 2012 CFR

2012-04-01

... PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.19 Restrictions concerning nondiscrimination against Section 8 certificate holders and voucher holders. The purchaser of any multifamily housing project shall not refuse unreasonably to...

24 CFR 27.1 - Purpose.

Code of Federal Regulations, 2014 CFR

2014-04-01

... FORECLOSURE OF MULTIFAMILY AND SINGLE FAMILY MORTGAGES Nonjudicial Foreclosure of Multifamily Mortgages § 27.1... Multifamily Mortgage Foreclosure Act of 1981 (the Act) (12 U.S.C. 3701-3717), that clarify, or are in addition... multifamily mortgages. Under a delegation of authority published on February 5, 1982 (47 FR 5468), the...

75 FR 60476 - Notice of Proposed Information Collection: Comment Request; HUD Multifamily Energy Assessment

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-30

... Information Collection: Comment Request; HUD Multifamily Energy Assessment AGENCY: Office of the Assistant... Multifamily Energy Assessment. OMB Control Number, if applicable: 2502-0568. Description of the need for the information and proposed use: The purpose of this information collection is to assist owners of multifamily...

12 CFR 1282.13 - Multifamily special affordable housing goal and subgoal.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 12 Banks and Banking 10 2014-01-01 2014-01-01 false Multifamily special affordable housing goal... AND MISSION ENTERPRISE HOUSING GOALS AND MISSION Housing Goals § 1282.13 Multifamily special affordable housing goal and subgoal. (a) Multifamily housing goal and subgoal. An Enterprise shall be in...

24 CFR 27.1 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-04-01

... FORECLOSURE OF MULTIFAMILY AND SINGLE FAMILY MORTGAGES Nonjudicial Foreclosure of Multifamily Mortgages § 27.1... Multifamily Mortgage Foreclosure Act of 1981 (the Act) (12 U.S.C. 3701-3717), that clarify, or are in addition... multifamily mortgages. Under a delegation of authority published on February 5, 1982 (47 FR 5468), the...

24 CFR 290.27 - Up-front grants and loans.

Code of Federal Regulations, 2012 CFR

2012-04-01

... URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.27 Up-front grants and loans. (a) General. HUD... development costs as part of the disposition of a multifamily housing project that is HUD-owned, upon making a...

12 CFR 1282.13 - Multifamily special affordable housing goal and subgoal.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Multifamily special affordable housing goal and... MISSION ENTERPRISE HOUSING GOALS AND MISSION Housing Goals § 1282.13 Multifamily special affordable housing goal and subgoal. (a) Multifamily housing goal and subgoal. An Enterprise shall be in compliance...

77 FR 30307 - Notice of HUD-Held Multifamily and Healthcare Loan Sale (MHLS 2012-2)

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-22

... Multifamily and Healthcare Loan Sale (MHLS 2012-2) AGENCY: Office of the Assistant Secretary for Housing... announces HUD's intention to sell certain unsubsidized multifamily and healthcare mortgage loans, without... loans (Mortgage Loans) secured by multifamily and healthcare properties located throughout the United...

76 FR 71593 - Notice of HUD-Held Multifamily and Healthcare Loan Sale (MHLS 2012-1)

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-18

... Multifamily and Healthcare Loan Sale (MHLS 2012-1) AGENCY: Office of the Assistant Secretary for Housing... notice announces HUD's intention to sell certain unsubsidized multifamily and healthcare mortgage loans... Loans) secured by multifamily and healthcare properties located throughout the United States. The...

75 FR 54900 - Notice of HUD-Held Multifamily and Healthcare Loan Sale (MHLS 2010-2)

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-09

... Multifamily and Healthcare Loan Sale (MHLS 2010-2) AGENCY: Office of the Assistant Secretary for Housing... announces HUD's intention to sell certain unsubsidized multifamily and healthcare mortgage loans, without... unsubsidized mortgage loans (Mortgage Loans) secured by multifamily and healthcare properties located...

School and Family Counselors Work Together to Reduce Fighting at School

ERIC Educational Resources Information Center

Canfield, Brian S.; Ballard, Mary B.; Osmon, Bonnie C.; McCune, Cecil

2004-01-01

To address the problem of fighting in four urban middle schools, school and family counselors collaborated to provide school-based multifamily counseling as an alternative to the mandatory 3-day external suspension program. Supported by district leaders and local school principals, the program was successful in reducing fighting recidivism rates.…

78 FR 14325 - Notice of Submission of Proposed Information Collection to OMB: FHA Insured Mortgage Loan...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-05

... (OMB) for review, as required by the Paperwork Reduction Act. The Department is soliciting public... resultant costs also serve to further stabilize the mortgage insurance premiums charged by FHA and the... Insurance Benefits, HUD-90035 Information/Disclosure, HUD-90041 Request for Variance, Pre-foreclosure sale...

76 FR 6149 - Federal Housing Administration (FHA): Temporary Exemption From Compliance With FHA's Regulation...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-03

... communities where foreclosure activity has been high. While the waiver is available for the purpose of... affect neighborhoods and communities. While HUD continues its efforts to help homeowners remain in their... and communities. As noted in its May 21, 2010, notice, HUD undertook similar waiver action in a...

75 FR 41225 - Federal Housing Administration (FHA) First Look Sales Method for Grantees, Nonprofit...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-15

... complete an approval process as required of other entities seeking to purchase REO properties under the FHA... process must meet the provisions of the NSP Guidance on Conditional Purchase Agreements found at http... Housing Commissioner, HUD. ACTION: Notice. SUMMARY: This notice outlines the process by which governmental...

Case Study of the Maplewood Park Multifamily Retrofit for Energy Efficiency

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, Euy-Jin; Stephenson, Robert; Roberts, Sydney

2012-12-01

Maplewood Park (Maplewood), a 110-unit multifamily apartment complex in Union City, Georgia, completed major renovations under the guidance of a third-party green building certification program in October 2012. Oak Ridge National Laboratory (ORNL) partnered with Southface Energy Institute (Southface) to use this project as a case study of energy retrofits in low-rise, garden-style, multifamily buildings in the southeastern United States. This report provides a comprehensive profile of this project including the project economics, findings of the building audit, and results of the analysis of energy retrofit measures specific to this project. With a main focus of energy retrofits, this reportmore » aims to discuss other aspects of multifamily building retrofit that would benefit future projects in terms of improved building audit process, streamlined tasks, and higher energy savings in low-rise, garden-style apartments. Maplewood received Low Income Housing Tax Credit (LIHTC) financing via the 2010 Georgia Qualified Allocation Plan (QAP). To be eligible for QAP funds in Georgia, all major renovations must incorporate energy-efficiency measures and adopt a third-party green building certification. Because of the unique demands of this financing, including requirements for long-term ownership, property owners were also especially motivated to invest in upgrades that will increase durability and comfort while reducing the energy cost for the tenants.« less

Field Testing of Compartmentalization Methods for Multifamily Construction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ueno, K.; Lstiburek, J.

The 2012 IECC has an airtightness requirement of 3 air changes per hour at 50 Pascals test pressure for both single-family and multifamily construction in Climate Zones 3-8. Other programs (LEED, ASHRAE 189, ASHRAE 62.2) have similar or tighter compartmentalization requirements, driving the need for easier and more effective methods of compartmentalization in multifamily buildings. Builders and practitioners have found that fire-resistance rated wall assemblies are a major source of difficulty in air sealing/compartmentalization, particularly in townhouse construction. This problem is exacerbated when garages are “tucked in” to the units and living space is located over the garages. In thismore » project, Building Science Corporation examined the taping of exterior sheathing details to improve air sealing results in townhouse and multifamily construction, when coupled with a better understanding of air leakage pathways. Current approaches are cumbersome, expensive, time consuming, and ineffective; these details were proposed as a more effective and efficient method. The effectiveness of these air sealing methods was tested with blower door testing, including “nulled” or “guarded” testing (adjacent units run at equal test pressure to null out inter-unit air leakage, or “pressure neutralization”). Pressure diagnostics were used to evaluate unit-to-unit connections and series leakage pathways (i.e., air leakage from exterior, into the fire-resistance rated wall assembly, and to the interior).« less

Long-term follow-up of functional hypothalamic amenorrhea and prognostic factors.

PubMed

Falsetti, Leopoldo; Gambera, Alessandro; Barbetti, Lorena; Specchia, Cristina

2002-02-01

This study evaluated the prognosis of functional hypothalamic amenorrhea (FHA) and the predictive factors of recovery, through a long-term follow-up. Ninety-three women affected by FHA underwent a follow-up for an average period of 8.1 yr (range 7-9 yr). At the end of the follow-up, 65 (70.7%) patients recovered. Statistical analysis showed that there was no association between recovery and anamnestic causes of FHA or with the echographic ovarian morphology but identified the predictive factors of recovery as the basal body mass index (BMI), the basal cortisol, and androstenedione plasma levels. A higher basal BMI and A, and lower cortisol values are positive prognostic factors for the recovery. Also the BMI, acquired during the follow-up, is important for FHA resolution: in fact, in recovered women the BMI increased or remained stable, whereas in nonrecovered women it decreased or remained stable. At the end of the follow-up, 52 (74.3%) patients treated with hormone replacement therapy and 8 (80%) with no therapy recovered, but only 5 (41.7%) with oral contraceptive pills recovered.

Enhancing the luminescence of Eu3+ /Eu2+ ion-doped hydroxyapatite by fluoridation and thermal annealing.

PubMed

Van, Hoang Nhu; Tam, Phuong Dinh; Kien, Nguyen Duc Trung; Huy, Pham Thanh; Pham, Vuong-Hung

2017-08-01

This paper reports a novel way for the synthesis of a europium (Eu)-doped fluor-hydroxyapatite (FHA) nanostructure to control the luminescence of hydroxyapatite nanophosphor, particularly, by applying optimum fluorine concentrations, annealed temperatures and pH value. The Eu-doped FHA was made using the co-precipitation method followed by thermal annealing in air and reducing in a H 2 atmosphere to control the visible light emission center of the nanophosphors. The intensities of the OH - group decreased with the increasing fluorine concentrations. For the specimens annealed in air, the light emission center of the nanophosphor was 615 nm, which was emission from the Eu 3 + ion. However, when they were annealed in reduced gas (Ar + 5% H 2 ), a 448 nm light emission center from the Eu 2 + ion of FHA was observed. The presence of fluorine in Eu-doped FHA resulted in a significant enhancement of nanophosphor luminescence, which has potential application in light emission and nanomedicine. Copyright © 2016 John Wiley & Sons, Ltd.

76 FR 66316 - Notice of Submission of Proposed Information Collection to OMB, Multifamily Insurance Benefits...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-26

... Proposed Information Collection to OMB, Multifamily Insurance Benefits Claims Package AGENCY: Office of the.... When the terms of a Multifamily contract are breached or when a mortgagee meets conditions stated within the Multifamily contract for an automatic assignment, the holder of the mortgage may file for...

24 CFR 290.21 - Computing annual number of units eligible for substitution of tenant-based assistance or...

Code of Federal Regulations, 2010 CFR

2010-04-01

... PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.21 Computing annual number of units eligible for substitution of tenant-based... the fiscal year, taking into consideration the total number of units in multifamily housing projects...

24 CFR 35.715 - Multifamily properties receiving more than $5,000 per unit.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Multifamily properties receiving... STRUCTURES Project-Based Assistance § 35.715 Multifamily properties receiving more than $5,000 per unit. The requirements of this section shall apply to a multifamily residential property that is receiving an average of...

24 CFR 290.21 - Computing annual number of units eligible for substitution of tenant-based assistance or...

Code of Federal Regulations, 2011 CFR

2011-04-01

... PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.21 Computing annual number of units eligible for substitution of tenant-based... the fiscal year, taking into consideration the total number of units in multifamily housing projects...

24 CFR 35.715 - Multifamily properties receiving more than $5,000 per unit.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Multifamily properties receiving... STRUCTURES Project-Based Assistance § 35.715 Multifamily properties receiving more than $5,000 per unit. The requirements of this section shall apply to a multifamily residential property that is receiving an average of...

24 CFR 35.625 - Multifamily insured property constructed after 1959 and before 1978.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Multifamily insured property constructed after 1959 and before 1978. 35.625 Section 35.625 Housing and Urban Development Office of the... RESIDENTIAL STRUCTURES Multifamily Mortgage Insurance § 35.625 Multifamily insured property constructed after...

24 CFR 35.715 - Multifamily properties receiving more than $5,000 per unit.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Multifamily properties receiving... STRUCTURES Project-Based Assistance § 35.715 Multifamily properties receiving more than $5,000 per unit. The requirements of this section shall apply to a multifamily residential property that is receiving an average of...

24 CFR 35.625 - Multifamily insured property constructed after 1959 and before 1978.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Multifamily insured property constructed after 1959 and before 1978. 35.625 Section 35.625 Housing and Urban Development Office of the... RESIDENTIAL STRUCTURES Multifamily Mortgage Insurance § 35.625 Multifamily insured property constructed after...

78 FR 40309 - 30-Day Notice of Proposed Information Collection: Application for Multifamily Project Mortgage...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-03

... No. FR-5683-N-55] 30-Day Notice of Proposed Information Collection: Application for Multifamily... Multifamily Project Mortgage Insurance. OMB Approval Number: 2502-0029. Type of Request: Revision of a... site. The forms are pdf fillable and will be sent by electronic mail with other required Multifamily...

24 CFR 55.22 - Conveyance restrictions for the disposition of multifamily real property.

Code of Federal Regulations, 2011 CFR

2011-04-01

... disposition of multifamily real property. 55.22 Section 55.22 Housing and Urban Development Office of the... Determinations on Floodplain Management § 55.22 Conveyance restrictions for the disposition of multifamily real property. (a) In the disposition (including leasing) of multifamily properties acquired by HUD that are...

24 CFR 55.22 - Conveyance restrictions for the disposition of multifamily real property.

Code of Federal Regulations, 2014 CFR

2014-04-01

... disposition of multifamily real property. 55.22 Section 55.22 Housing and Urban Development Office of the... restrictions for the disposition of multifamily real property. (a) In the disposition (including leasing) of multifamily properties acquired by HUD that are located in a floodplain (a 500-year floodplain for a Critical...

24 CFR 290.21 - Computing annual number of units eligible for substitution of tenant-based assistance or...

Code of Federal Regulations, 2012 CFR

2012-04-01

... PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.21 Computing annual number of units eligible for substitution of tenant-based... the fiscal year, taking into consideration the total number of units in multifamily housing projects...

24 CFR 290.21 - Computing annual number of units eligible for substitution of tenant-based assistance or...

Code of Federal Regulations, 2014 CFR

2014-04-01

... PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.21 Computing annual number of units eligible for substitution of tenant-based... the fiscal year, taking into consideration the total number of units in multifamily housing projects...

24 CFR 35.625 - Multifamily insured property constructed after 1959 and before 1978.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Multifamily insured property constructed after 1959 and before 1978. 35.625 Section 35.625 Housing and Urban Development Office of the... RESIDENTIAL STRUCTURES Multifamily Mortgage Insurance § 35.625 Multifamily insured property constructed after...

24 CFR 55.22 - Conveyance restrictions for the disposition of multifamily real property.

Code of Federal Regulations, 2012 CFR

2012-04-01

... disposition of multifamily real property. 55.22 Section 55.22 Housing and Urban Development Office of the... Determinations on Floodplain Management § 55.22 Conveyance restrictions for the disposition of multifamily real property. (a) In the disposition (including leasing) of multifamily properties acquired by HUD that are...

24 CFR 35.625 - Multifamily insured property constructed after 1959 and before 1978.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Multifamily insured property constructed after 1959 and before 1978. 35.625 Section 35.625 Housing and Urban Development Office of the... RESIDENTIAL STRUCTURES Multifamily Mortgage Insurance § 35.625 Multifamily insured property constructed after...

[Multifamily therapy in children with learning disabilities].

PubMed

Retzlaff, Rüdiger; Brazil, Susanne; Goll-Kopka, Andrea

2008-01-01

Multifamily therapy is an evidence-based method used in the treatment and prevention of severe psychiatric disorders, behavioral problems and physical illnesses in children, adolescents and adults. For preventive family-oriented work with children with learning disorders there is a lack of therapeutic models. This article presents results from an innovative pilot project--multiple family groups for families with a learning disabled child of primary school age (six to eleven years old). Based on a systemic approach, this resource-oriented program integrates creative, activity-based interventions and group therapy techniques and conveys a comprehensive understanding of the challenges associated with learning disorders. Because of the pilot character of the study and the small sample size, the results have to be interpreted with care. The results do however clearly support the wider implementation and evaluation of the program in child guidance clinics, social-pediatric centers, as well as child and adolescent clinics and schools.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Building cost effective, high performance homes that provide superior comfort, health, and durability is the goal of the Department of Energy's (DOE's) Zero Energy Ready Homes (ZERH) program. Through Building America research and other innovative programs throughout the country, many of the technical challenges to building to the ZERH standard have been addressed. This case study describes the development of a 62-unit multifamily community constructed by nonprofit developer Mutual Housing at the Spring Lake subdivision in Woodland, CA. The Spring Lake project is expected to be the first ZERH-certified multifamily project nationwide. Building America team Alliance for Residential Building Innovationmore » worked with Mutual Housing throughout the project. The case study discusses challenges encountered, lessons learned, and how obstacles were overcome. An objective of this project was to gain a highly visible foothold for residential buildings built to the DOE ZERH specification that can be used to encourage participation by other California builders.« less

Discordant orthostatic reflex renin-angiotensin and sympathoneural responses in premenopausal exercising-hypoestrogenic women.

PubMed

O'Donnell, Emma; Goodman, Jack M; Mak, Susanna; Murai, Hisayoshi; Morris, Beverley L; Floras, John S; Harvey, Paula J

2015-05-01

Our prior observations in normotensive postmenopausal women stimulated the hypotheses that compared with eumenorrheic women, active hypoestrogenic premenopausal women with functional hypothalamic amenorrhea would demonstrate attenuated reflex renin-angiotensin-aldosterone system responses to an orthostatic challenge, whereas to defend blood pressure reflex increases in muscle, sympathetic nerve activity would be augmented. To test these hypotheses, we assessed, in recreationally active women, 12 with amenorrhea (ExFHA; aged 25 ± 1 years; body mass index 20.7 ± 0.7 kg/m(2); mean ± SEM) and 17 with eumenorrhea (ExOv; 24 ± 1 years; 20.9 ± 0.5 kg/m(2)), blood pressure, heart rate, plasma renin, angiotensin II, aldosterone, and muscle sympathetic nerve activity at supine rest and during graded lower body negative pressure (-10, -20, and -40 mm Hg). At baseline, heart rate and systolic blood pressure were lower (P<0.05) in ExFHA (47 ± 2 beats/min and 94 ± 2 mm Hg) compared with ExOv (56 ± 2 beats/min and 105 ± 2 mm Hg), but muscle sympathetic nerve activity and renin-angiotensin-aldosterone system constituents were similar (P>0.05). In response to graded lower body negative pressure, heart rate increased (P<0.05) and systolic blood pressure decreased (P<0.05) in both groups, but these remained consistently lower in ExFHA (P<0.05). Lower body negative pressure elicited increases (P<0.05) in renin, angiotensin II, and aldosterone in ExOv, but not in ExFHA (P>0.05). Muscle sympathetic nerve activity burst incidence increased reflexively in both groups, but more so in ExFHA (P<0.05). Otherwise, healthy hypoestrogenic ExFHA women demonstrate low blood pressure and disruption of the normal circulatory response to an orthostatic challenge: plasma renin, angiotensin II, and aldosterone fail to increase and blood pressure is defended by an augmented sympathetic vasoconstrictor response. © 2015 American Heart Association, Inc.

The formation of FHA coating on biodegradable Mg-Zn-Zr alloy using a two-step chemical treatment method

NASA Astrophysics Data System (ADS)

Jiang, S. T.; Zhang, J.; Shun, S. Z.; Chen, M. F.

2016-12-01

To improve the corrosion resistance of the biomedical magnesium alloy, a two-step chemical treatment method has been employed to prepare an FHA coating on the alloy surface. Prior to forming an FHA layer, the samples of Mg-3 wt% Zn-0.5 wt% Zr alloy were soaked in HF with concentration of 20% (v/v) at 37 °C temperature for 2 h, and were then placed into an aqueous solution with 0.1 mol/L Ca(NO3).4H2O and 0.06 mol/L NH4H2PO4 at 90 °C to prepare the Ca-P coating. The concentrations of Mg2+, F- ions, and pH variation with immersing time in the solution were investigated to explore the growth mechanism of FHA. The surface morphologies and compositions of the coatings were characterized by X-ray diffraction, scanning electron microscopy, and energy dispersive spectroscopy. The results showed that the alloy surface treated with acid formed a layer of MgF2 nanoparticles with a thickness of 0.7 μm. The corrosion resistance of coatings in SBF solution was evaluated by electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization. The results showed that the substrate with FHA coating had good corrosion resistance. After immersing into the calcium phosphate solution, some small spherical particles were first formed on the surface; these then cover the surface completely after 20 min. Some clusters consisting of needle-like crystal were observed in the spherical particles covering the surface, and the Ca/P ratio of the needle-like crystal was 1.46, clearly growing along the c axis preferred orientation growth. After immersion for 60 min, the FHA coating with completely uniform growth was obtained on the Mg-Zn-Zr alloy surface with its thickness reaching about 120 μm.

Strategies to reverse bone loss in women with functional hypothalamic amenorrhea: a systematic review of the literature.

PubMed

Vescovi, J D; Jamal, S A; De Souza, M J

2008-04-01

Functional hypothalamic amenorrhea (FHA) impairs the attainment of peak bone mass and as such can increase the risk of fractures later in life. To document available treatment strategies, we conducted a systematic review of the literature. We report that hormonal therapies have limited effectiveness in increasing bone mass, whereas increased caloric intake resulting in weight gain and/or resumption of menses is an essential strategy for restoring bone mass in women with FHA. Women with functional hypothalamic amenorrhea (FHA) may not achieve peak bone mass (PBM), which increases the risk of stress fractures, and may increase the risk of osteoporotic fractures in later life. To identify effective treatment strategies for women with FHA, we conducted a systematic review of the literature. We included randomized controlled trials (RCTs), cross-sectional studies, and case studies that reported on the effects of pharmacological and non-pharmacological interventions on bone mineral density (BMD) or bone turnover in women with FHA. Most published studies (n=26) were designed to treat the hormonal abnormalities observed in women with FHA (such as low estrogen, leptin, insulin-like growth factor-1, and DHEA); however none of these treatments demonstrated consistent improvements in BMD. Therapies containing an estrogen given for 8-24 months resulted in variable improvements (1.0-19.0%) in BMD, but failed to restore bone mass to that of age-matched controls. Three studies reported on the use of bisphosphonates (3-12 months) in anorexic women, which appear to have limited effectiveness to improve BMD compared to nutritional treatments. Another three investigations showed no improvements in BMD after androgen therapy (DHEA and testosterone) in anorexic women. In contrast, reports (n=9) describing an increase in caloric intake that results in weight gain and/or the resumption of menses reported a 1.1-16.9% increase in BMD concomitant with an improvement in bone formation and reduction in bone resorption markers. Our literature review indicates that the most successful, and indeed essential strategy for improving BMD in women with FHA is to increase caloric intake such that body mass is increased and there is a resumption of menses. Further long-term studies to determine the persistence of this effect and to determine the effects of this and other strategies on fracture risk are needed.

24 CFR 35.720 - Multifamily properties receiving up to $5,000 per unit, and single family properties.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Multifamily properties receiving up... PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Project-Based Assistance § 35.720 Multifamily properties... requirements of this section shall apply to a multifamily residential property that is receiving an average of...

24 CFR 35.720 - Multifamily properties receiving up to $5,000 per unit, and single family properties.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Multifamily properties receiving up... PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Project-Based Assistance § 35.720 Multifamily properties... requirements of this section shall apply to a multifamily residential property that is receiving an average of...

24 CFR 35.720 - Multifamily properties receiving up to $5,000 per unit, and single family properties.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Multifamily properties receiving up... PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Project-Based Assistance § 35.720 Multifamily properties... requirements of this section shall apply to a multifamily residential property that is receiving an average of...

24 CFR 35.720 - Multifamily properties receiving up to $5,000 per unit, and single family properties.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Multifamily properties receiving up... PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Project-Based Assistance § 35.720 Multifamily properties... requirements of this section shall apply to a multifamily residential property that is receiving an average of...

Evaluation of Passive Vents in New Construction Multifamily Buildings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maxwell, Sean; Berger, David; Zuluaga, Marc

Exhaust ventilation and corresponding outdoor air strategies are being implemented in high-performance new construction multifamily buildings to meet program or code requirements for improved indoor air quality, but a lack of clear design guidance is resulting in poor performance of these systems despite the best intentions of the programs or standards. CARB's 2014 'Evaluation of Ventilation Strategies in New Construction Multifamily Buildings' consistently demonstrated that commonly used outdoor air strategies are not performing as expected. Of the four strategies evaluated in 2014, the exhaust ventilation system that relied on outdoor air from a pressurized corridor was ruled out as amore » potential best practice due to its conflict with meeting requirements within most fire codes. Outdoor air that is ducted directly to the apartments was a strategy determined to have the highest likelihood of success, but with higher first costs and operating costs. Outdoor air through space conditioning systems was also determined to have good performance potential, with proper design and execution. The fourth strategy, passive systems, was identified as the least expensive option for providing outdoor air directly to apartments, with respect to both first costs and operating costs. However, little is known about how they actually perform in real-world conditions or how to implement them effectively. Based on the lack of data available on the performance of these low-cost systems and their frequent use in the high-performance building programs that require a provision for outdoor air, this research project sought to further evaluate the performance of passive vents.« less

Building America Case Study: Evaluation of Passive Vents in New-Construction Multifamily Buildings, New York, New York

DOE Office of Scientific and Technical Information (OSTI.GOV)

Exhaust ventilation and corresponding outdoor air strategies are being implemented in high-performance new construction multifamily buildings to meet program or code requirements for improved indoor air quality, but a lack of clear design guidance is resulting in poor performance of these systems despite the best intentions of the programs or standards. CARB's 2014 'Evaluation of Ventilation Strategies in New Construction Multifamily Buildings' consistently demonstrated that commonly used outdoor air strategies are not performing as expected. Of the four strategies evaluated in 2014, the exhaust ventilation system that relied on outdoor air from a pressurized corridor was ruled out as amore » potential best practice due to its conflict with meeting requirements within most fire codes. Outdoor air that is ducted directly to the apartments was a strategy determined to have the highest likelihood of success, but with higher first costs and operating costs. Outdoor air through space conditioning systems was also determined to have good performance potential, with proper design and execution. The fourth strategy, passive systems, was identified as the least expensive option for providing outdoor air directly to apartments, with respect to both first costs and operating costs. However, little is known about how they actually perform in real-world conditions or how to implement them effectively. Based on the lack of data available on the performance of these low-cost systems and their frequent use in the high-performance building programs that require a provision for outdoor air, this research project sought to further evaluate the performance of passive vents.« less

76 FR 71067 - Privacy Act of 1974; Notification To Delete and Create a New System of Records, “HUD/FHA Lender...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-16

... Electronic Assessment Portal AGENCY: Office of the Chief Information Officer, HUD. ACTION: Notification to... or officers of financial institutions seeking approval or approved to originate, service, or hold FHA..., 2011. Jerry E. Williams, Chief Information Officer. HUD/SF01.2502 SYSTEM NAME: Lender Electronic...

76 FR 81363 - Federal Housing Administration (FHA): Temporary Exemption From Compliance With FHA's Regulation...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-28

... (202) 708-2121 (this is not a toll-free number). Persons with hearing or speech impairments may access this number through TTY by calling the toll-free Federal Information Relay Service at (800) 877-8339... is resold for a considerable profit with an artificially inflated value, often the result of a lender...

78 FR 70066 - 60-Day Notice of Proposed Information Collection: FHA Stakeholder Feedback for the New FHA Single...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-22

... interested parties on the proposed collection of information. The purpose of this notice is to allow for 60 days of public comment. DATES: Comments Due Date: January 21, 2014. ADDRESSES: Interested persons are... simple, more directive language Aligning the flow of the handbook to the lender/mortgage process. Without...

78 FR 64143 - 30-Day Notice of Proposed Information Collection: FHA-Application for Insurance of Advance of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-25

... Information Collection: FHA-Application for Insurance of Advance of Mortgage Proceeds AGENCY: Office of the... collection requirement described below to the Office of Management and Budget (OMB) for review, in accordance.../or OMB Control Number and should be sent to: HUD Desk Officer, Office of Management and Budget, New...

Cross protection against fowl cholera disease with the use of recombinant Pasteurella multocida FHAB2 peptides vaccine

USDA-ARS?s Scientific Manuscript database

It has been demonstrated that fhaB2 (filamentous hemagglutinin) is an important virulence factor for P. multocida in development of fowl cholera disease and that recombinant FHAB2 peptides derived from P. multocida, Pm-1059, protect turkeys against Pm-1059 challenge. To test the hypothesis that rFHA...

7 CFR Exhibit A to Subpart A of... - Memorandum of Understanding Between Commodity Credit Corporation and Farmers Home Administration...

Code of Federal Regulations, 2011 CFR

2011-01-01

... SERVICE, RURAL BUSINESS-COOPERATIVE SERVICE, RURAL UTILITIES SERVICE, AND FARM SERVICE AGENCY, DEPARTMENT... against the loan(s) secured by such lien: 1. When an FHA County Supervisor learns that an FHA borrower has... peanut producer cooperative marketing associations through which CCC makes price support available to...

24 CFR 290.11 - Notification requirements.

Code of Federal Regulations, 2011 CFR

2011-04-01

... URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.11 Notification requirements. (a) In general...

24 CFR 290.11 - Notification requirements.

Code of Federal Regulations, 2014 CFR

2014-04-01

... URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.11 Notification requirements. (a) In general...

24 CFR 290.11 - Notification requirements.

Code of Federal Regulations, 2012 CFR

2012-04-01

... URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.11 Notification requirements. (a) In general...

Treatment of functional hypothalamic amenorrhea with hypnotherapy.

PubMed

Tschugguel, Walter; Berga, Sarah L

2003-10-01

To determine the effects of hypnotherapy on resumption of menstruation in patients with functional hypothalamic amenorrhea (FHA). Uncontrolled clinical study. Academic clinical care center. Twelve consecutive women with FHA were selected. A single 45- to 70-minute session of hypnotherapy was administered, and patients were observed for 12 weeks. Patients were asked whether or not menstruation resumed and whether or not well-being and self-confidence changed. Within 12 weeks, 9 out of 12 patients (75%) resumed menstruation. All of the patients, including those who did not menstruate, reported several beneficial side effects such as increased general well-being and increased self-confidence. Hypnotherapy could be an efficacious and time-saving treatment option that also avoids the pitfalls of pharmacological modalities for women with FHA.

Multifamily group treatment in a program for patients with first-episode psychosis: experiences from the TIPS project.

PubMed

Fjell, Anne; Bloch Thorsen, Gerd Ragna; Friis, Svein; Johannessen, Jan Olav; Larsen, Tor K; Lie, Kari; Lyse, Hanne-Grethe; Melle, Ingrid; Simonsen, Erik; Smeby, Nina Aarhus; Øxnevad, Anne Lise; McFarlane, William R; Vaglum, Per; McGlashan, Thomas

2007-02-01

Psychoeducational multifamily group treatment based on the McFarlane model was implemented for adult patients experiencing a first episode of psychosis and for the families of 301 patients. Patients were participants in a research project in Norway and Denmark. Of 301 patients 246 were invited to participate and 147 agreed. Patients' reluctance to participate increased with age. Most had to wait between six and 12 months until a sufficient number was gathered to start a group. Treatment was well received by patients and families. Care should be taken to prevent a long delay before group commencement at this stressful period in the lives of patients and families.

76 FR 51998 - Announcement of Funding Awards for the Service Coordinators in Multifamily Housing Fiscal Year 2009

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-19

... Recipient: Catholic Charities of St. Paul and Minneapolis Property Name: Mary Hall SRO Occupancy Program...: $148,599 Recipient: Tri-Vision Housing Corporation Property Name: Wisteria Way Address: 204-8 Hospital...

77 FR 71445 - Regulatory and Administrative Waivers Granted for Multifamily Housing Programs To Assist With...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-30

... property, loss of life, and displacement of individuals and families from their homes and communities. The... is published quarterly. Since the damage to property and the displacement of families and individuals...

78 FR 36232 - Announcement of Funding Awards; Service Coordinators in Multifamily Housing Program, Fiscal Year...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-17

.... Preservation LP. MI....... Romulus Non- Whispering 11100 Wayne Rd. Romulus 65 159,643 Profit Housing Willows...'Keefe 2130 SW White San Antonio 50 246,302 Apartments. Apts. Rd. VA....... Holiday Village Holiday...

24 CFR 290.13 - Negotiated sales.

Code of Federal Regulations, 2012 CFR

2012-04-01

... DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.13 Negotiated sales. When HUD conducts a negotiated sale...

24 CFR 290.13 - Negotiated sales.

Code of Federal Regulations, 2014 CFR

2014-04-01

... DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.13 Negotiated sales. When HUD conducts a negotiated sale...

24 CFR 290.13 - Negotiated sales.

Code of Federal Regulations, 2011 CFR

2011-04-01

... DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.13 Negotiated sales. When HUD conducts a negotiated sale...

Guidelines for Home Energy Professionals Project: Multifamily Job Task Analyses Needs Assessment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dirr, N.; Hepinstall, D.; Douglas, M.

This report describes the efforts carried out to determine whether there is a need to develop separate, multifamily-specific JTAs for the four proposed job categories. The multifamily SWS market committee considered these job designations to be the best candidates for developing JTAs and certification blueprints, as well as having the greatest potential for promoting job growth in the multifamily home performance industry.

Effects of incorporation of nano-fluorapatite or nano-fluorohydroxyapatite on a resin-modified glass ionomer cement.

PubMed

Lin, Jun; Zhu, Jiajun; Gu, Xiaoxia; Wen, Wenjian; Li, Qingshan; Fischer-Brandies, Helge; Wang, Huiming; Mehl, Christian

2011-03-01

This study aimed to investigate the fluoride release properties and the effect on bond strength of two experimental adhesive cements. Synthesized particles of nano-fluorapatite (nano-FA) or nano-fluorohydroxyapatite (nano-FHA) were incorporated into a resin-modified glass ionomer cement (Fuji Ortho LC) and characterized using X-ray diffraction and scanning electron microscopy. Blocks with six different concentrations of nano-FA or nano-FHA were manufactured and their fluoride release properties evaluated by ultraviolet spectrophotometry. The unaltered glass ionomer cement Fuji Ortho LC (GC, control) and the two experimental cements with the highest fluoride release capacities (nano-FA+Fuji Ortho LC (GFA) and nano-FHA+Fuji Ortho LC (GFHA)) were used to bond composite blocks and orthodontic brackets to human enamel. After 24 h water storage all specimens were debonded, measuring the micro-tensile bond strength (μTBS) and the shear bond strength (SBS), respectively. The optimal concentration of added nano-FA and nano-FHA for maximum fluoride release was 25 wt.%, which nearly tripled fluoride release after 70 days compared with the control group. GC exhibited a significantly higher SBS than GFHA/GFA, with GFHA and GFA not differing significantly (P>0.05). The μTBS of GC and GFA were significantly higher than that of GFHA (P≤0.05). The results seem to indicate that the fluoride release properties of Fuji Ortho LC are improved by incorporating nano-FA or nano-FHA, simultaneously maintaining a clinically sufficient bond strength when nano-FA was added. Copyright © 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Forkhead-associated (FHA) Domain Containing ABC Transporter Rv1747 Is Positively Regulated by Ser/Thr Phosphorylation in Mycobacterium tuberculosis*

PubMed Central

Spivey, Vicky L.; Molle, Virginie; Whalan, Rachael H.; Rodgers, Angela; Leiba, Jade; Stach, Lasse; Walker, K. Barry; Smerdon, Stephen J.; Buxton, Roger S.

2011-01-01

One major signaling method employed by Mycobacterium tuberculosis, the causative agent of tuberculosis, is through reversible phosphorylation of proteins mediated by protein kinases and phosphatases. This study concerns one of these enzymes, the serine/threonine protein kinase PknF, that is encoded in an operon with Rv1747, an ABC transporter that is necessary for growth of M. tuberculosis in vivo and contains two forkhead-associated (FHA) domains. FHA domains are phosphopeptide recognition motifs that specifically recognize phosphothreonine-containing epitopes. Experiments to determine how PknF regulates the function of Rv1747 demonstrated that phosphorylation occurs on two specific threonine residues, Thr-150 and Thr-208. To determine the in vivo consequences of phosphorylation, infection experiments were performed in bone marrow-derived macrophages and in mice using threonine-to-alanine mutants of Rv1747 that prevent specific phosphorylation and revealed that phosphorylation positively modulates Rv1747 function in vivo. The role of the FHA domains in this regulation was further demonstrated by isothermal titration calorimetry, using peptides containing both phosphothreonine residues. FHA-1 domain mutation resulted in attenuation in macrophages highlighting the critical role of this domain in Rv1747 function. A mutant deleted for pknF did not, however, have a growth phenotype in an infection, suggesting that other kinases can fulfill its role when it is absent. This study provides the first information on the molecular mechanism(s) regulating Rv1747 through PknF-dependent phosphorylation but also indicates that phosphorylation activates Rv1747, which may have important consequences in regulating growth of M. tuberculosis. PMID:21622570

24 CFR 266.500 - General.

Code of Federal Regulations, 2010 CFR

2010-04-01

... AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and... of this subpart and for managing and servicing projects insured under this part. The HFA is responsible for monitoring and determining the compliance of the project owner in accordance with the...

24 CFR 200.53 - Initial operating funds.

Code of Federal Regulations, 2010 CFR

2010-04-01

... standards established by the Commissioner for: (a) Accruals for taxes, ground rates, mortgage insurance premiums, and property insurance premiums, during the course of construction; (b) Meeting the cost of... Endorsement Generally Applicable to Multifamily and Health Care Facility Mortgage Insurance Programs; and...

24 CFR 200.53 - Initial operating funds.

Code of Federal Regulations, 2011 CFR

2011-04-01

... standards established by the Commissioner for: (a) Accruals for taxes, ground rates, mortgage insurance premiums, and property insurance premiums, during the course of construction; (b) Meeting the cost of... Endorsement Generally Applicable to Multifamily and Health Care Facility Mortgage Insurance Programs; and...

7 CFR 1955.101 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Community and Business Programs (C&BP) and Multi-Family Housing (MFH) which will be handled in accordance... Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... REGULATIONS (CONTINUED) PROPERTY MANAGEMENT Disposal of Inventory Property § 1955.101 Purpose. This subpart...

24 CFR 266.500 - General.

Code of Federal Regulations, 2012 CFR

2012-04-01

... AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and... of this subpart and for managing and servicing projects insured under this part. The HFA is responsible for monitoring and determining the compliance of the project owner in accordance with the...

24 CFR 266.500 - General.

Code of Federal Regulations, 2013 CFR

2013-04-01

... AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and... of this subpart and for managing and servicing projects insured under this part. The HFA is responsible for monitoring and determining the compliance of the project owner in accordance with the...

24 CFR 266.500 - General.

Code of Federal Regulations, 2014 CFR

2014-04-01

... AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and... of this subpart and for managing and servicing projects insured under this part. The HFA is responsible for monitoring and determining the compliance of the project owner in accordance with the...

24 CFR 266.500 - General.

Code of Federal Regulations, 2011 CFR

2011-04-01

... AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Project Management and... of this subpart and for managing and servicing projects insured under this part. The HFA is responsible for monitoring and determining the compliance of the project owner in accordance with the...

24 CFR 200.35 - Appraisal standards-nondiscrimination requirements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Application, Commitment, and Endorsement Generally Applicable to Multifamily and Health Care Facility Mortgage Insurance Programs; and Continuing Eligibility Requirements for Existing Projects Miscellaneous Cross... the selection of appraiser. In the selection of an appraiser, there shall be no discrimination on the...

24 CFR 200.35 - Appraisal standards-nondiscrimination requirements.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Application, Commitment, and Endorsement Generally Applicable to Multifamily and Health Care Facility Mortgage Insurance Programs; and Continuing Eligibility Requirements for Existing Projects Miscellaneous Cross... the selection of appraiser. In the selection of an appraiser, there shall be no discrimination on the...

77 FR 71099 - Federal Housing Administration (FHA): Temporary Waiver of FHA's Regulation on Property Flipping...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-29

... hearing or speech impairments may access this number through TTY by calling the toll-free Federal Relay... considerable profit with an artificially inflated value, often as the result of a lender's collusion with an... waiver only if the mortgagee: a. Justifies the increase in value by retaining in the loan file a second...

24 CFR 290.37 - Requirements for continuing Federal rental subsidy contracts.

Code of Federal Regulations, 2014 CFR

2014-04-01

... COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Sale of HUD-Held Multifamily Mortgages § 290.37...

24 CFR 290.39 - Nondiscrimination in admitting certificate and voucher holders.

Code of Federal Regulations, 2014 CFR

2014-04-01

... COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Sale of HUD-Held Multifamily Mortgages § 290.39...

24 CFR 290.39 - Nondiscrimination in admitting certificate and voucher holders.

Code of Federal Regulations, 2012 CFR

2012-04-01

... COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Sale of HUD-Held Multifamily Mortgages § 290.39...

24 CFR 290.18 - Restrictions on sale to former mortgagors.

Code of Federal Regulations, 2011 CFR

2011-04-01

... HOUSING AND URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.18 Restrictions on sale to former...

24 CFR 290.18 - Restrictions on sale to former mortgagors.

Code of Federal Regulations, 2014 CFR

2014-04-01

... HOUSING AND URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.18 Restrictions on sale to former...

24 CFR 290.39 - Nondiscrimination in admitting certificate and voucher holders.

Code of Federal Regulations, 2011 CFR

2011-04-01

... COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Sale of HUD-Held Multifamily Mortgages § 290.39...

24 CFR 290.39 - Nondiscrimination in admitting certificate and voucher holders.

Code of Federal Regulations, 2010 CFR

2010-04-01

... COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Sale of HUD-Held Multifamily Mortgages § 290.39...

24 CFR 290.18 - Restrictions on sale to former mortgagors.

Code of Federal Regulations, 2010 CFR

2010-04-01

... HOUSING AND URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.18 Restrictions on sale to former...

24 CFR 290.18 - Restrictions on sale to former mortgagors.

Code of Federal Regulations, 2012 CFR

2012-04-01

... HOUSING AND URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.18 Restrictions on sale to former...

24 CFR 290.37 - Requirements for continuing Federal rental subsidy contracts.

Code of Federal Regulations, 2012 CFR

2012-04-01

... COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Sale of HUD-Held Multifamily Mortgages § 290.37...

24 CFR 290.37 - Requirements for continuing Federal rental subsidy contracts.

Code of Federal Regulations, 2011 CFR

2011-04-01

... COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Sale of HUD-Held Multifamily Mortgages § 290.37...