Final postflight hardware evaluation report RSRM-28 (STS-53)

NASA Technical Reports Server (NTRS)

Starrett, William David, Jr.

1993-01-01

The final report for the Clearfield disassembly evaluation and a continuation of the KSC postflight assessment for the RSRM-28 (STS-53) RSRM flight set is presented. All observed hardware conditions were documented on PFOR's and are included in Appendices A through C. Appendices D and E contain the measurements and safety factor data for the nozzle and insulation components. This report, along with the KSC Ten-Day Postflight Hardware Evaluation Report (TWR-64215), represents a summary of the RSRM-28 hardware evaluation. The as-flown hardware configuration is documented in TWR-63638. Disassembly evaluation photograph numbers are logged in TWA-1989. The RSRM-28 flight set disassembly evaluations described were performed at the RSRM Refurbishment Facility in Clearfield, Utah. The final factory joint demate occurred on July 15, 1993. Additional time was required to perform the evaluation of the stiffener rings per special issue 4.1.5.2 because of the washout schedule. The release of this report was after completion of all special issues per program management direction. Detailed evaluations were performed in accordance with the Clearfield PEEP, TWR-50051, Revision A. All observations were compared against limits that are also defined in the PEEP. These limits outline the criteria for categorizing the observations as acceptable, reportable, or critical. Hardware conditions that were unexpected and/or determined to be reportable or critical were evaluated by the applicable team and tracked through the PFAR system.

76 FR 70706 - Frontseating Service Valves From the People's Republic of China: Final Results of the 2008-2010...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-15

... more of the following components: A valve body, field connection tube, factory connection tube or valve charge port. The valve body is a rectangular block, or brass forging, machined to be hollow in the interior, with a generally square shaped seat (bottom of body). The field connection tube and factory...

14. INTERIOR VIEW OF THIRD FLOOR OF FACTORY ADDITION, NORTHWEST ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. INTERIOR VIEW OF THIRD FLOOR OF FACTORY ADDITION, NORTHWEST CORNER OF BUILDING. AT THE CENTER IS THE BUFFING MACHINE, MANUFACTURED BY THE ACME CO. OF DETROIT, MICHIGAN. IT WAS HERE THAT ALUMINUM WARES WERE BROUGHT FOR FINAL GRINDING AND BUFFING. THE HOSES REMOVED DUST AND DEBRIS. - Illinois Pure Aluminum Company, 109 Holmes Street, Lemont, Cook County, IL

Investigation Of The Effects Of Reflow Profile Parameters On Lead-free Solder Bump Volumes And Joint Integrity

NASA Astrophysics Data System (ADS)

Amalu, E. H.; Lui, Y. T.; Ekere, N. N.; Bhatti, R. S.; Takyi, G.

2011-01-01

The electronics manufacturing industry was quick to adopt and use the Surface Mount Technology (SMT) assembly technique on realization of its huge potentials in achieving smaller, lighter and low cost product implementations. Increasing global customer demand for miniaturized electronic products is a key driver in the design, development and wide application of high-density area array package format. Electronic components and their associated solder joints have reduced in size as the miniaturization trend in packaging continues to be challenged by printing through very small stencil apertures required for fine pitch flip-chip applications. At very narrow aperture sizes, solder paste rheology becomes crucial for consistent paste withdrawal. The deposition of consistent volume of solder from pad-to-pad is fundamental to minimizing surface mount assembly defects. This study investigates the relationship between volume of solder paste deposit (VSPD) and the volume of solder bump formed (VSBF) after reflow, and the effect of reflow profile parameters on lead-free solder bump formation and the associated solder joint integrity. The study uses a fractional factorial design (FFD) of 24-1 Ramp-Soak-Spike reflow profile, with all main effects and two-way interactions estimable to determine the optimal factorial combination. The results from the study show that the percentage change in the VSPD depends on the combination of the process parameters and reliability issues could become critical as the size of solder joints soldered on the same board assembly vary greatly. Mathematical models describe the relationships among VSPD, VSBF and theoretical volume of solder paste. Some factors have main effects across the volumes and a number of interactions exist among them. These results would be useful for R&D personnel in designing and implementing newer applications with finer-pitch interconnect.

Postflight hardware evaluation 360T026 (RSRM-26, STS-47)

NASA Technical Reports Server (NTRS)

Nielson, Greg

1993-01-01

The final report for the Clearfield disassembly evaluation and a continuation of the KSC postflight assessment for the 360T026 (STS-47) Redesigned Solid Rocket Motor (RSRM) flight set is provided. All observed hardware conditions were documented on PFOR's and are included in Appendices A, B, and C. Appendices D and E contain the measurements and safety factor data for the nozzle and insulation components. This report, along with the KSC Ten-Day Postflight Hardware Evaluation Report (TWR-64203), represents a summary of the 360T026 hardware evaluation. The as-flown hardware configuration is documented in TWR-60472. Disassembly evaluation photograph numbers are logged in TWA-1987. The 360T026 flight set disassembly evaluations described were performed at the RSRM Refurbishment Facility in Clearfield, Utah. The final factory joint demate occurred on 12 April 1993. Detailed evaluations were performed in accordance with the Clearfield Postflight Engineering Evaluation Plan (PEEP), TWR-50051, Revision A. All observations were compared against limits that are also defined in the PEEP. These limits outline the criteria for categorizing the observations as acceptable, reportable, or critical. Hardware conditions that were unexpected and/or determined to be reportable or critical were evaluated by the applicable CPT and tracked through the PFAR system.

Affective Beliefs Influence the Experience of Eating Meat

PubMed Central

Anderson, Eric C.; Barrett, Lisa Feldman

2016-01-01

People believe they experience the world objectively, but research continually demonstrates that beliefs influence perception. Emerging research indicates that beliefs influence the experience of eating. In three studies, we test whether beliefs about how animals are raised can influence the experience of eating meat. Samples of meat were paired with descriptions of animals raised on factory farms or raised on humane farms. Importantly, the meat samples in both conditions were identical. However, participants experienced the samples differently: meat paired with factory farm descriptions looked, smelled, and tasted less pleasant. Even basic properties of flavor were influenced: factory farmed samples tasted more salty and greasy. Finally, actual behavior was influenced: participants consumed less when samples were paired with factory farm descriptions. These findings demonstrate that the experience of eating is not determined solely by physical properties of stimuli—beliefs also shape experience. PMID:27556643

Smart factory in the context of 4th industrial revolution: challenges and opportunities for Romania

NASA Astrophysics Data System (ADS)

Pîrvu, B. C.; Zamfirescu, C. B.

2017-08-01

Manufacturing companies, independent of operation sector and size, must be able to produce lot size one products, just-in-time at a competitive cost. Coping with this high adaptability and short reaction times proves to be very challenging. New approaches must be taken into consideration for designing modular, intelligent and cooperative production systems which are easy to integrate with the entire factory. The coined term for this network of intelligent interacting artefacts system is cyber-physical systems (CPS). CPS is often used in the context of Industry 4.0 - or what many consider the forth industrial revolution. The paper presents an overview of key technological and social requirements to map the Smart Factory vision into reality. Finally, global and Romanian specific challenges hindering the vision of a true Smart Factory to become reality are presented.

JPRS Report, Environmental Issues.

DTIC Science & Technology

1990-12-06

Station To Close [ ADN International 14 NovJ 104 Groundwater Pollution Research Projects Announced , 104 Volkswagen Foundation Subsidizes Joint...some 275 million. The experts said: "Many U.S. factories and cities have historically sent their waste to Mexico , Central America, and Canada...help to farmers. Here are just two examples. The fruit fly has almost vanished in Mexico , and that means half a billion dollars of additional profits

Preliminary 2-D shell analysis of the space shuttle solid rocket boosters

NASA Technical Reports Server (NTRS)

Knight, Norman F., Jr.; Gillian, Ronnie E.; Nemeth, Michael P.

1987-01-01

A two-dimensional shell model of an entire solid rocket booster (SRB) has been developed using the STAGSC-1 computer code and executed on the Ames CRAY computer. The purpose of these analyses is to calculate the overall deflection and stress distributions for the SRB when subjected to mechanical loads corresponding to critical times during the launch sequence. The mechanical loading conditions for the full SRB arise from the external tank (ET) attachment points, the solid rocket motor (SRM) pressure load, and the SRB hold down posts. The ET strut loads vary with time after the Space Shuttle main engine (SSME) ignition. The SRM internal pressure varies axially by approximately 100 psi. Static analyses of the full SRB are performed using a snapshot picture of the loads. The field and factory joints are modeled by using equivalent stiffness joints instead of detailed models of the joint. As such, local joint behavior cannot be obtained from this global model.

Design of a Communication Scheme in a Modern Factory in Accordance with the Standard of Industry 4.0

NASA Astrophysics Data System (ADS)

Halenár, Igor; Juhásová, Bohuslava; Juhás, Martin

2016-12-01

This article first describes the current state of the problem in the area of communication in modern factories. Next in the article is given a summary of the requirements that must be implemented for the possibility of establishing a compatible and safe communication system. In the final part of the article is given a proposal of communication model suitable for the implementation.

Optimization and Prediction of Angular Distortion and Weldment Characteristics of TIG Square Butt Joints

NASA Astrophysics Data System (ADS)

Narang, H. K.; Mahapatra, M. M.; Jha, P. K.; Biswas, P.

2014-05-01

Autogenous arc welds with minimum upper weld bead depression and lower weld bead bulging are desired as such welds do not require a second welding pass for filling up the upper bead depressions (UBDs) and characterized with minimum angular distortion. The present paper describes optimization and prediction of angular distortion and weldment characteristics such as upper weld bead depression and lower weld bead bulging of TIG-welded structural steel square butt joints. Full factorial design of experiment was utilized for selecting the combinations of welding process parameter to produce the square butts. A mathematical model was developed to establish the relationship between TIG welding process parameters and responses such as upper bead width, lower bead width, UBD, lower bead height (bulging), weld cross-sectional area, and angular distortions. The optimal welding condition to minimize UBD and lower bead bulging of the TIG butt joints was identified.

JPRS Report, East Europe

DTIC Science & Technology

1988-10-24

designers and a well-equipped tool shop and hence is able to produce single-purpose machine tools, the plant must make everything on its own...In both plants special offices have been organized whose goal is jointly to develop new design , technological proposals and to define directions...same factory or plant . I have a couple of questions for the supporters of the thus interpreted pluralism. Does not this mean a schism in the trade

Adapting Scott and Bruce's General Decision-Making Style Inventory to Patient Decision Making in Provider Choice.

PubMed

Fischer, Sophia; Soyez, Katja; Gurtner, Sebastian

2015-05-01

Research testing the concept of decision-making styles in specific contexts such as health care-related choices is missing. Therefore, we examine the contextuality of Scott and Bruce's (1995) General Decision-Making Style Inventory with respect to patient choice situations. Scott and Bruce's scale was adapted for use as a patient decision-making style inventory. In total, 388 German patients who underwent elective joint surgery responded to a questionnaire about their provider choice. Confirmatory factor analyses within 2 independent samples assessed factorial structure, reliability, and validity of the scale. The final 4-dimensional, 13-item patient decision-making style inventory showed satisfactory psychometric properties. Data analyses supported reliability and construct validity. Besides the intuitive, dependent, and avoidant style, a new subdimension, called "comparative" decision-making style, emerged that originated from the rational dimension of the general model. This research provides evidence for the contextuality of decision-making style to specific choice situations. Using a limited set of indicators, this report proposes the patient decision-making style inventory as valid and feasible tool to assess patients' decision propensities. © The Author(s) 2015.

New generation electron-positron factories

NASA Astrophysics Data System (ADS)

Zobov, Mikhail

2011-09-01

In 2010 we celebrate 50 years since commissioning of the first particle storage ring ADA in Frascati (Italy) that also became the first electron-positron collider in 1964. After that date the particle colliders have increased their intensity, luminosity and energy by several orders of magnitude. Namely, because of the high stored beam currents and high rate of useful physics events (luminosity) the modern electron-positron colliders are called "factories". However, the fundamental physics has required luminosities by 1-2 orders of magnitudes higher with respect to those presently achieved. This task can be accomplished by designing a new generation of factories exploiting the potential of a new collision scheme based on the Crab Waist (CW) collision concept recently proposed and successfully tested at Frascati. In this paper we discuss the performance and limitations of the present generation electron-positron factories and give a brief overview of new ideas and collision schemes proposed for further collider luminosity increase. In more detail we describe the CW collision concept and the results of the crab waist collision tests in DAϕNE, the Italian ϕ-factory. Finally, we briefly describe most advanced projects of the next generation factories based on the CW concept: SuperB in Italy, SuperKEKB in Japan and SuperC-Tau in Russia.

Front End for a neutrino factory or muon collider

DOE PAGES

Neuffer, David; Snopok, Pavel; Alexahin, Yuri

2017-11-30

A neutrino factory or muon collider requires the capture and cooling of a large number of muons. Scenarios for capture, bunching, phase-energy rotation and initial cooling of μ’s produced from a proton source target have been developed, initially for neutrino factory scenarios. They require a drift section from the target, a bunching section and a Φ-δE rotation section leading into the cooling channel. Important concerns are rf limitations within the focusing magnetic fields and large losses in the transport. The currently preferred cooling channel design is an “HFOFO Snake” configuration that cools both μ + and μ - transversely andmore » longitudinally. Finally, the status of the design is presented and variations are discussed.« less

Development and psychometric evaluation of the Premarital Sexual Behavior Assessment Scale for Young Women (PSAS-YW): an exploratory mixed method study.

PubMed

Rahmani, Azam; Merghati-Khoei, Effat; Moghadam-Banaem, Lida; Hajizadeh, Ebrahim; Hamdieh, Mostafa; Montazeri, Ali

2014-06-13

Premarital sexual behaviors are important issue for women's health. The present study was designed to develop and examine the psychometric properties of a scale in order to identify young women who are at greater risk of premarital sexual behavior. This was an exploratory mixed method investigation. Indeed, the study was conducted in two phases. In the first phase, qualitative methods (focus group discussion and individual interview) were applied to generate items and develop the questionnaire. In the second phase, psychometric properties (validity and reliability) of the questionnaire were assessed. In the first phase an item pool containing 53 statements related to premarital sexual behavior was generated. In the second phase item reduction was applied and the final version of the questionnaire containing 26 items was developed. The psychometric properties of this final version were assessed and the results showed that the instrument has a good structure, and reliability. The results from exploratory factory analysis indicated a 5-factor solution for the instrument that jointly accounted for the 57.4% of variance observed. The Cronbach's alpha coefficient for the instrument was found to be 0.87. This study provided a valid and reliable scale to identify premarital sexual behavior in young women. Assessment of premarital sexual behavior might help to improve women's sexual abstinence.

Development and psychometric evaluation of the Premarital Sexual Behavior Assessment Scale for Young Women (PSAS-YW): an exploratory mixed method study

PubMed Central

2014-01-01

Background Premarital sexual behaviors are important issue for women’s health. The present study was designed to develop and examine the psychometric properties of a scale in order to identify young women who are at greater risk of premarital sexual behavior. Method This was an exploratory mixed method investigation. Indeed, the study was conducted in two phases. In the first phase, qualitative methods (focus group discussion and individual interview) were applied to generate items and develop the questionnaire. In the second phase, psychometric properties (validity and reliability) of the questionnaire were assessed. Results In the first phase an item pool containing 53 statements related to premarital sexual behavior was generated. In the second phase item reduction was applied and the final version of the questionnaire containing 26 items was developed. The psychometric properties of this final version were assessed and the results showed that the instrument has a good structure, and reliability. The results from exploratory factory analysis indicated a 5-factor solution for the instrument that jointly accounted for the 57.4% of variance observed. The Cronbach’s alpha coefficient for the instrument was found to be 0.87. Conclusion This study provided a valid and reliable scale to identify premarital sexual behavior in young women. Assessment of premarital sexual behavior might help to improve women’s sexual abstinence. PMID:24924696

Offsets in International Weapons Acquisitions: The Turkish Experience

DTIC Science & Technology

2002-03-01

future civilian needs, a contract was signed with CASA ( Construcciones Aeronauticas SA) of Spain in 1990 for the joint production of 52 CN-235...housed in a large, newly constructed factory, was to assemble and co-produce the F-16 in Turkiye, and to provide support for the program including...project in Turkiye with Bechtel, the giant U.S. engineering and construction firm based in San Francisco. General Dynamics invested about $20 million

An artificial reality environment for remote factory control and monitoring

NASA Technical Reports Server (NTRS)

Kosta, Charles Paul; Krolak, Patrick D.

1993-01-01

Work has begun on the merger of two well known systems, VEOS (HITLab) and CLIPS (NASA). In the recent past, the University of Massachusetts Lowell developed a parallel version of NASA CLIPS, called P-CLIPS. This modification allows users to create smaller expert systems which are able to communicate with each other to jointly solve problems. With the merger of a VEOS message system, PCLIPS-V can now act as a group of entities working within VEOS. To display the 3D virtual world we have been using a graphics package called HOOPS, from Ithaca Software. The artificial reality environment we have set up contains actors and objects as found in our Lincoln Logs Factory of the Future project. The environment allows us to view and control the objects within the virtual world. All communication between the separate CLIPS expert systems is done through VEOS. A graphical renderer generates camera views on X-Windows devices; Head Mounted Devices are not required. This allows more people to make use of this technology. We are experimenting with different types of virtual vehicles to give the user a sense that he or she is actually moving around inside the factory looking ahead through windows and virtual monitors.

Public health assessment for public health implications of radiation contamination at former clock factories located in Bristo (Hartford County), New Haven, (New Haven County), Thomaston (Litchfield County), and Waterbury (New Haven County), Connecticut, Region 1. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

This public health assessment was developed (1) to evaluate the radiation data collected by the Connecticut Department of Environmental Protection (CT DEP) at structures that once housed clock factories in four Connecticut municipalities, and (2) to determine whether a public health hazard exists at any of these sites from the contamination. Contamination was detected at levels that may pose a health risk to current occupants at the former Waterbury Clock Factory, the former Lux Clock Factory, and the former Benrus Clock Company buildings in Waterbury; the former Sessions Clock Company in Bristol; and the former Seth Thomas Clock Company inmore » Thomaston. However, none of the radiation levels detected pose an immediate health problem. The Connecticut Department of Public Health recommends that individuals be disassociated from areas with radiation at levels exceeding 15 mRem/year.« less

Final Environmental Assessment: Solar Panel Systems at Joint Base McGuire-Dix-Lakehurst New Jersey

DTIC Science & Technology

2012-03-01

FINAL ENVIRONMENTAL ASSESSMENT Solar Panel Systems at Joint Base McGuire-Dix-Lakehurst, New Jersey MARCH 2012...Final Environmental Assessment : Solar Panel Systems at Joint Base McGuire-Dix-Lakehurst New Jersey 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM...unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 Purpose Finding of No Significant Impact (FONSI) Environmental Assessment (EA

Research on the Decision Method of Maintenance Materials Direct Supply

NASA Astrophysics Data System (ADS)

Zhu, Qian; Shi, Xiaopei; Liu, Shenyang; Luo, Guangxu; Zhu, Chen

2018-05-01

With the further development of civil military integration, more and more maintenance materials will be supplied by the factory directly. Aiming at the mode condition of maintenance materials factory direct supply, maintenance materials needs equipment support in the process of facing a number of direct supply manufacturers how to decision problems, using AHP, considering many factors optimization of direct supply manufacturers involved, and gives the weights of the evaluation indexes of the direct supply manufacturers to evaluate optimal. Finally, with 4 straights for the manufacturer as an example, considering the various evaluation indexes to carry out evaluation and drawing the correct evaluation of direct supply manufacturers, the best manufacturers direct supply is selected. An example shows that, AHP can provide scientific and theoretical basis to materials factory direct supply security.

Case of Contamination by Listeria Monocytogenes in Mozzarella Cheese

PubMed Central

Tolli, Rita; Bossù, Teresa; Rodas, Eda Maria Flores; Di Giamberardino, Fabiola; Di Sirio, Alessandro; Vita, Silvia; De Angelis, Veronica; Bilei, Stefano; Sonnessa, Michele; Gattuso, Antonietta; Lanni, Luigi

2014-01-01

Following a Listeria monocytogenes detection in a mozzarella cheese sampled at a dairy plant in Lazio Region, further investigations have been conducted both by the competent Authority and the food business operatordairy factory (as a part of dairy factory HACCP control). In total, 90 dairy products, 7 brine and 64 environmental samples have been tested. The prevalence of Listeria monocytogenes was 24.4% in mozzarella cheese, and 9.4% in environmental samples, while brines were all negatives. Forty-seven strains of L. monocytogenes have been isolated, all belonging to 4b/4e serotype. In 12 of these, the macrorestriction profile has been determined by means of pulsed field gel electrophoresis. The profiles obtained with AscI enzyme showed a 100% similarity while those obtained with ApaI a 96.78% similarity. These characteristics of the isolated strains jointly with the production process of mozzarella cheese has allowed to hypothesise an environmental contamination. PMID:27800317

76 FR 65746 - Notice of Availability of Joint Final Environmental Impact Statement/Final Environmental Impact...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-24

... Boulevard. The project will consist of up to 128 wind turbines (1.5 to 3.0 MW each) with a generating... Statement/Final Environmental Impact Report for the Tule Wind Project, California, and Notice of Intent To... Final Environmental Impact Report (EIR) as a joint environmental analysis document for Tule Wind, LLC's...

Impact of a private sector living wage intervention on depressive symptoms among apparel workers in the Dominican Republic: a quasi-experimental study

PubMed Central

Burmaster, Katharine B; Landefeld, John C; Rehkopf, David H; Lahiff, Maureen; Sokal-Gutierrez, Karen; Adler-Milstein, Sarah; Fernald, Lia C H

2015-01-01

Objectives Poverty reduction interventions through cash transfers and microcredit have had mixed effects on mental health. In this quasi-experimental study, we evaluate the effect of a living wage intervention on depressive symptoms of apparel factory workers in the Dominican Republic. Setting Two apparel factories in the Dominican Republic. Participants The final sample consisted of 204 hourly wage workers from the intervention (99) and comparison (105) factories. Interventions In 2010, an apparel factory began a living wage intervention including a 350% wage increase and significant workplace improvements. The wage increase was plausibly exogenous because workers were not aware of the living wage when applying for jobs and expected to be paid the usual minimum wage. These individuals were compared with workers at a similar local factory paying minimum wage, 15–16 months postintervention. Primary outcome measures Workers’ depressive symptoms were assessed using the Center for Epidemiologic Studies-Depression Scale (CES-D). Ordinary least squares and Poisson regressions were used to evaluate treatment effect of the intervention, adjusted for covariates. Results Intervention factory workers had fewer depressive symptoms than comparison factory workers (unadjusted mean CES-D scores: 10.6±9.3 vs 14.7±11.6, p=0.007). These results were sustained when controlling for covariates (β=−5.4, 95% CI −8.5 to −2.3, p=0.001). In adjusted analyses using the standard CES-D clinical cut-off of 16, workers at the intervention factory had a 47% reduced risk of clinically significant levels of depressive symptoms compared with workers at the comparison factory (23% vs 40%). Conclusions Policymakers have long grappled with how best to improve mental health among populations in low-income and middle-income countries. We find that providing a living wage and workplace improvements to improve income and well-being in a disadvantaged population is associated with reduced depressive symptoms. PMID:26238394

Buckling of a Longitudinally Jointed Curved Composite Panel Arc Segment for Next Generation of Composite Heavy Lift Launch Vehicles: Verification Testing Analysis

NASA Technical Reports Server (NTRS)

Farrokh, Babak; Segal, Kenneth N.; Akkerman, Michael; Glenn, Ronald L.; Rodini, Benjamin T.; Fan, Wei-Ming; Kellas, Sortiris; Pineda, Evan J.

2014-01-01

In this work, an all-bonded out-of-autoclave (OoA) curved longitudinal composite joint concept, intended for use in the next generation of composite heavy lift launch vehicles, was evaluated and verified through finite element (FE) analysis, fabrication, testing, and post-test inspection. The joint was used to connect two curved, segmented, honeycomb sandwich panels representative of a Space Launch System (SLS) fairing design. The overall size of the resultant panel was 1.37 m by 0.74 m (54 in by 29 in), of which the joint comprised a 10.2 cm (4 in) wide longitudinal strip at the center. NASTRAN and ABAQUS were used to perform linear and non-linear analyses of the buckling and strength performance of the jointed panel. Geometric non-uniformities (i.e., surface contour imperfections) were measured and incorporated into the FE model and analysis. In addition, a sensitivity study of the specimens end condition showed that bonding face-sheet doublers to the panel's end, coupled with some stress relief features at corner-edges, can significantly reduce the stress concentrations near the load application points. Ultimately, the jointed panel was subjected to a compressive load. Load application was interrupted at the onset of buckling (at 356 kN 80 kips). A post-test non-destructive evaluation (NDE) showed that, as designed, buckling occurred without introducing any damage into the panel or the joint. The jointed panel was further capable of tolerating an impact damage to the same buckling load with no evidence of damage propagation. The OoA cured all-composite joint shows promise as a low mass factory joint for segmented barrels.

The space shuttle advanced solid rocket motor: Quality control and testing

NASA Technical Reports Server (NTRS)

1991-01-01

The Congressional committees that authorize the activities of NASA requested that the National Research Council (NRC) review the testing and quality assurance programs for the Advanced Solid Rocket Motor (ASRM) program. The proposed ASRM design incorporates numerous features that are significant departures from the Redesigned Solid Rocket Motor (RSRM). The NRC review concentrated mainly on these features. Primary among these are the steel case material, welding rather than pinning of case factory joints, a bolted field joint designed to close upon firing the rocket, continuous mixing and casting of the solid propellant in place of the current batch processes, use of asbestos-free insulation, and a lightweight nozzle. The committee's assessment of these and other features of the ASRM are presented in terms of their potential impact on flight safety.

78 FR 65274 - Certain Lined Paper Products From the People's Republic of China: Notice of Final Results and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-31

... current review covers three exporters: Leo's Quality Products Co., Ltd./Denmax Plastic Stationery Factory (Leo/Denmax), Shanghai Lian Li Paper Products Co., Ltd. (Lian Li), and Hwa Fuh Plastics Co., Ltd./Li Teng Plastics (Shenzhen) Co., Ltd. (Hwa Fuh/Li Teng). For these final results, we made no changes to...

Mobile Monitoring and Embedded Control System for Factory Environment

PubMed Central

Lian, Kuang-Yow; Hsiao, Sung-Jung; Sung, Wen-Tsai

2013-01-01

This paper proposes a real-time method to carry out the monitoring of factory zone temperatures, humidity and air quality using smart phones. At the same time, the system detects possible flames, and analyzes and monitors electrical load. The monitoring also includes detecting the vibrations of operating machinery in the factory area. The research proposes using ZigBee and Wi-Fi protocol intelligent monitoring system integration within the entire plant framework. The sensors on the factory site deliver messages and real-time sensing data to an integrated embedded systems via the ZigBee protocol. The integrated embedded system is built by the open-source 32-bit ARM (Advanced RISC Machine) core Arduino Due module, where the network control codes are built in for the ARM chipset integrated controller. The intelligent integrated controller is able to instantly provide numerical analysis results according to the received data from the ZigBee sensors. The Android APP and web-based platform are used to show measurement results. The built-up system will transfer these results to a specified cloud device using the TCP/IP protocol. Finally, the Fast Fourier Transform (FFT) approach is used to analyze the power loads in the factory zones. Moreover, Near Field Communication (NFC) technology is used to carry out the actual electricity load experiments using smart phones. PMID:24351642

Mobile monitoring and embedded control system for factory environment.

PubMed

Lian, Kuang-Yow; Hsiao, Sung-Jung; Sung, Wen-Tsai

2013-12-17

This paper proposes a real-time method to carry out the monitoring of factory zone temperatures, humidity and air quality using smart phones. At the same time, the system detects possible flames, and analyzes and monitors electrical load. The monitoring also includes detecting the vibrations of operating machinery in the factory area. The research proposes using ZigBee and Wi-Fi protocol intelligent monitoring system integration within the entire plant framework. The sensors on the factory site deliver messages and real-time sensing data to an integrated embedded systems via the ZigBee protocol. The integrated embedded system is built by the open-source 32-bit ARM (Advanced RISC Machine) core Arduino Due module, where the network control codes are built in for the ARM chipset integrated controller. The intelligent integrated controller is able to instantly provide numerical analysis results according to the received data from the ZigBee sensors. The Android APP and web-based platform are used to show measurement results. The built-up system will transfer these results to a specified cloud device using the TCP/IP protocol. Finally, the Fast Fourier Transform (FFT) approach is used to analyze the power loads in the factory zones. Moreover, Near Field Communication (NFC) technology is used to carry out the actual electricity load experiments using smart phones.

Prevalence of Listeria monocytogenes in Retail Lightly Pickled Vegetables and Its Successful Control at Processing Plants.

PubMed

Taguchi, Masumi; Kanki, Masashi; Yamaguchi, Yuko; Inamura, Hideichi; Koganei, Yosuke; Sano, Tetsuya; Nakamura, Hiromi; Asakura, Hiroshi

2017-03-01

Incidences of food poisoning traced to nonanimal food products have been increasingly reported. One of these was a recent large outbreak of Shiga toxin-producing Escherichia coli (STEC) O157 infection from the consumption of lightly pickled vegetables, indicating the necessity of imposing hygienic controls during manufacturing. However, little is known about the bacterial contamination levels in these minimally processed vegetables. Here we examined the prevalence of STEC, Salmonella spp., and Listeria monocytogenes in 100 lightly pickled vegetable products manufactured at 55 processing factories. Simultaneously, we also performed quantitative measurements of representative indicator bacteria (total viable counts, coliform counts, and β-glucuronidase-producing E. coli counts). STEC and Salmonella spp. were not detected in any of the samples; L. monocytogenes was detected in 12 samples manufactured at five of the factories. Microbiological surveillance at two factories (two surveys at factory A and three surveys at factory B) between June 2014 and January 2015 determined that the areas predominantly contaminated with L. monocytogenes included the refrigerators and packaging rooms. Genotyping provided further evidence that the contaminants found in these areas were linked to those found in the final products. Taken together, we demonstrated the prevalence of L. monocytogenes in lightly pickled vegetables sold at the retail level. Microbiological surveillance at the manufacturing factories further clarified the sources of the contamination in the retail products. These data indicate the necessity of implementing adequate monitoring programs to minimize health risks attributable to the consumption of these minimally processed vegetables.

Proceedings of the AIAA/FAA Joint Symposium on General Aviation Systems Held in Wichita, Kansas on 16-17 March 1992

DTIC Science & Technology

1992-06-01

the problems of that system should address the GA segment 11 General Aviation Shipments and Billings 35,000- 3.00 30,000 -2.50 25,000 -2.00 Factory...avoidance; . certification: time/cost for licensing, "* Airport noise: rate of closings; curfews 22 PROGRESS IN TECHNOLOGY NONAL CAL "* airbags * anti...demonstrated that the technical problems involved with transmitting significant amounts of weather data to an aircraft in-flight or on-the-ground via

High-Performance Liquid Chromatography (HPLC) Quantification of Liposome-Delivered Doxorubicin in Arthritic Joints of Collagen-Induced Arthritis Rats.

PubMed

Niu, Hongqing; Xu, Menghua; Li, Shuangtian; Chen, Junwei; Luo, Jing; Zhao, Xiangcong; Gao, Chong; Li, Xiaofeng

2017-04-14

BACKGROUND Neoangiogenesis occurring in inflamed articular synovium in early rheumatoid arthritis (RA) is characterized by enhanced vascular permeability that allows nanoparticle agents, including liposomes, to deliver encapsulated drugs to arthritic joints and subsequently improve therapeutic efficacy and reduce adverse effects. However, the targeting distribution of liposomes in arthritic joints during RA has not been quantitatively demonstrated. We performed this study to evaluate the targeting distribution of PEGylated doxorubicin liposomes in the arthritic joints of collagen-induced arthritis (CIA) rats by high-performance liquid chromatography (HPLC). MATERIAL AND METHODS Two doxorubicin formulations were administered to CIA rats via tail intravenous injection at a single dose (50 mg/m²). CIA rats were sacrificed and the tissues of the inflamed ankle joints were collected. The content of doxorubicin in the arthritic joints was analyzed by a validated and reproducible HPLC method. A two-way ANOVA for 2×5 factorial design was used for statistical analysis. RESULTS The developed HPLC method was sensitive, precise, and reproducible. The method was successfully applied to quantify doxorubicin content in arthritic tissues. At each time point (6, 12, 24, 48, and 72 h), doxorubicin content in the arthritic joints of the doxorubicin liposome group (DOX-LIP group) was higher than in the free doxorubicin group (DOX group) (P<0.05). In the DOX-LIP group, doxorubicin levels in the arthritic joints increased gradually and significantly in the interval of 6-72 h post-administration. CONCLUSIONS PEGylated doxorubicin liposomes were targeted to, accumulated, and retained in the arthritic joints of CIA rats. The present study indicates that liposome encapsulation increases the therapeutic efficacy of antirheumatic drugs, presenting a promising therapeutic strategy for RA.

The HERrespect intervention to address violence against female garment workers in Bangladesh: study protocol for a quasi-experimental trial.

PubMed

Al Mamun, Mahfuz; Parvin, Kausar; Yu, Marat; Wan, Jessica; Willan, Samantha; Gibbs, Andrew; Jewkes, Rachel; Naved, Ruchira Tabassum

2018-04-18

Women in Bangladesh experience high rates of Intimate Partner Violence (IPV). IPV is more prevalent against income earning women compared to their non-earning counterparts, and Workplace Violence (WPV) is also common. Such violence is a violation of women's rights, and also constrains them from contributing to their personal growth, household, community and the economy at large. There is limited evidence on what works to prevent IPV and WPV amongst garment workers. This paper describes an evaluation of HERrespect, an intervention which aims to reduce IPV and WPV against female garment workers in and around Dhaka, Bangladesh. The trial employs a quasi-experimental design, with four intervention and four control factories. In the intervention factories a randomly selected cohort of married female line workers, a cohort of male line workers, and all middle management staff received the intervention. The intervention strategies involved (1) gender transformative group-based training for workers and management staff; (2) joint session between workers (15 female and male) and middle-management staff; (3) factory-wide activities; (4) awareness raising among top management; (5) factory policy review and development and 6) a community based campaign. For the evaluation, a cohort of randomly selected female workers and a cohort of selected management staff have been established. All workers (n = 800) and management staff (n = 395) from these cohorts were interviewed at baseline using two different questionnaires, and will be interviewed in the endline, 24 months post-baseline. Intention to treat analysis will be used for assessing the impact of HERrespect, comparing the intervention and control factories. To our knowledge this is the first study that seeks to evaluate the impact on IPV and WPV, of group sessions with female workers, male workers, and management; factory-wide campaigns and a community intervention among female garment workers in Bangladesh. Apart from informing programmers and policy makers about intervention effectiveness in reducing IPV and WPV against female garment workers this study will also present evidence on an intervention tailored to the situation in the garment sector, which makes HERrespect scalable. ClinicalTrials.gov NCT03304015, retrospectively registered on October 06, 2017.

Sample size requirements for separating out the effects of combination treatments: randomised controlled trials of combination therapy vs. standard treatment compared to factorial designs for patients with tuberculous meningitis.

PubMed

Wolbers, Marcel; Heemskerk, Dorothee; Chau, Tran Thi Hong; Yen, Nguyen Thi Bich; Caws, Maxine; Farrar, Jeremy; Day, Jeremy

2011-02-02

In certain diseases clinical experts may judge that the intervention with the best prospects is the addition of two treatments to the standard of care. This can either be tested with a simple randomized trial of combination versus standard treatment or with a 2 x 2 factorial design. We compared the two approaches using the design of a new trial in tuberculous meningitis as an example. In that trial the combination of 2 drugs added to standard treatment is assumed to reduce the hazard of death by 30% and the sample size of the combination trial to achieve 80% power is 750 patients. We calculated the power of corresponding factorial designs with one- to sixteen-fold the sample size of the combination trial depending on the contribution of each individual drug to the combination treatment effect and the strength of an interaction between the two. In the absence of an interaction, an eight-fold increase in sample size for the factorial design as compared to the combination trial is required to get 80% power to jointly detect effects of both drugs if the contribution of the less potent treatment to the total effect is at least 35%. An eight-fold sample size increase also provides a power of 76% to detect a qualitative interaction at the one-sided 10% significance level if the individual effects of both drugs are equal. Factorial designs with a lower sample size have a high chance to be underpowered, to show significance of only one drug even if both are equally effective, and to miss important interactions. Pragmatic combination trials of multiple interventions versus standard therapy are valuable in diseases with a limited patient pool if all interventions test the same treatment concept, it is considered likely that either both or none of the individual interventions are effective, and only moderate drug interactions are suspected. An adequately powered 2 x 2 factorial design to detect effects of individual drugs would require at least 8-fold the sample size of the combination trial. Current Controlled Trials ISRCTN61649292.

Metabolic engineering of Saccharomyces cerevisiae: a key cell factory platform for future biorefineries.

PubMed

Hong, Kuk-Ki; Nielsen, Jens

2012-08-01

Metabolic engineering is the enabling science of development of efficient cell factories for the production of fuels, chemicals, pharmaceuticals, and food ingredients through microbial fermentations. The yeast Saccharomyces cerevisiae is a key cell factory already used for the production of a wide range of industrial products, and here we review ongoing work, particularly in industry, on using this organism for the production of butanol, which can be used as biofuel, and isoprenoids, which can find a wide range of applications including as pharmaceuticals and as biodiesel. We also look into how engineering of yeast can lead to improved uptake of sugars that are present in biomass hydrolyzates, and hereby allow for utilization of biomass as feedstock in the production of fuels and chemicals employing S. cerevisiae. Finally, we discuss the perspectives of how technologies from systems biology and synthetic biology can be used to advance metabolic engineering of yeast.

Asphaltic concrete overlays of rigid and flexible pavements : final report.

DOT National Transportation Integrated Search

1980-10-01

This study evaluated the effect of a given thickness of asphaltic concrete overlay in rehabilitating 53 test sections conforming to the experiment design. This factorial design specified various levels of traffic intensity and overlay thickness for b...

The Joint European Compound Library: boosting precompetitive research.

PubMed

Besnard, Jérémy; Jones, Philip S; Hopkins, Andrew L; Pannifer, Andrew D

2015-02-01

The Joint European Compound Library (JECL) is a new high-throughput screening collection aimed at driving precompetitive drug discovery and target validation. The JECL has been established with a core of over 321,000 compounds from the proprietary collections of seven pharmaceutical companies and will expand to around 500,000 compounds. Here, we analyse the physicochemical profile and chemical diversity of the core collection, showing that the collection is diverse and has a broad spectrum of predicted biological activity. We also describe a model for sharing compound information from multiple proprietary collections, enabling diversity and quality analysis without disclosing structures. The JECL is available for screening at no cost to European academic laboratories and SMEs through the IMI European Lead Factory (http://www.europeanleadfactory.eu/). Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

Impact of a private sector living wage intervention on depressive symptoms among apparel workers in the Dominican Republic: a quasi-experimental study.

PubMed

Burmaster, Katharine B; Landefeld, John C; Rehkopf, David H; Lahiff, Maureen; Sokal-Gutierrez, Karen; Adler-Milstein, Sarah; Fernald, Lia C H

2015-08-03

Poverty reduction interventions through cash transfers and microcredit have had mixed effects on mental health. In this quasi-experimental study, we evaluate the effect of a living wage intervention on depressive symptoms of apparel factory workers in the Dominican Republic. Two apparel factories in the Dominican Republic. The final sample consisted of 204 hourly wage workers from the intervention (99) and comparison (105) factories. In 2010, an apparel factory began a living wage intervention including a 350% wage increase and significant workplace improvements. The wage increase was plausibly exogenous because workers were not aware of the living wage when applying for jobs and expected to be paid the usual minimum wage. These individuals were compared with workers at a similar local factory paying minimum wage, 15-16 months postintervention. Workers' depressive symptoms were assessed using the Center for Epidemiologic Studies-Depression Scale (CES-D). Ordinary least squares and Poisson regressions were used to evaluate treatment effect of the intervention, adjusted for covariates. Intervention factory workers had fewer depressive symptoms than comparison factory workers (unadjusted mean CES-D scores: 10.6 ± 9.3 vs 14.7 ± 11.6, p = 0.007). These results were sustained when controlling for covariates (β = -5.4, 95% CI -8.5 to -2.3, p = 0.001). In adjusted analyses using the standard CES-D clinical cut-off of 16, workers at the intervention factory had a 47% reduced risk of clinically significant levels of depressive symptoms compared with workers at the comparison factory (23% vs 40%). Policymakers have long grappled with how best to improve mental health among populations in low-income and middle-income countries. We find that providing a living wage and workplace improvements to improve income and well-being in a disadvantaged population is associated with reduced depressive symptoms. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

77 FR 39560 - International Joint Commission

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-03

... DEPARTMENT OF STATE [Public Notice 7945] International Joint Commission International Joint Commission Invites Public Comment on Upper Great Lakes Report The International Joint Commission (IJC) announced today that it is inviting public comment on the final report of its International Upper Great...

Planning for the semiconductor manufacturer of the future

NASA Technical Reports Server (NTRS)

Fargher, Hugh E.; Smith, Richard A.

1992-01-01

Texas Instruments (TI) is currently contracted by the Air Force Wright Laboratory and the Defense Advanced Research Projects Agency (DARPA) to develop the next generation flexible semiconductor wafer fabrication system called Microelectronics Manufacturing Science & Technology (MMST). Several revolutionary concepts are being pioneered on MMST, including the following: new single-wafer rapid thermal processes, in-situ sensors, cluster equipment, and advanced Computer Integrated Manufacturing (CIM) software. The objective of the project is to develop a manufacturing system capable of achieving an order of magnitude improvement in almost all aspects of wafer fabrication. TI was awarded the contract in Oct., 1988, and will complete development with a fabrication facility demonstration in April, 1993. An important part of MMST is development of the CIM environment responsible for coordinating all parts of the system. The CIM architecture being developed is based on a distributed object oriented framework made of several cooperating subsystems. The software subsystems include the following: process control for dynamic control of factory processes; modular processing system for controlling the processing equipment; generic equipment model which provides an interface between processing equipment and the rest of the factory; specification system which maintains factory documents and product specifications; simulator for modelling the factory for analysis purposes; scheduler for scheduling work on the factory floor; and the planner for planning and monitoring of orders within the factory. This paper first outlines the division of responsibility between the planner, scheduler, and simulator subsystems. It then describes the approach to incremental planning and the way in which uncertainty is modelled within the plan representation. Finally, current status and initial results are described.

Recovery of yttrium from fluorescent powder of cathode ray tube, CRT: Zn removal by sulphide precipitation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Innocenzi, Valentina, E-mail: valentina.innocenzi1@univaq.it; De Michelis, Ida; Ferella, Francesco

2013-11-15

Highlights: • Treatment of fluorescent powder of CRT waste. • Factorial experimental designs to study acid leaching of fluorescent powder and the purification of leach liquors. • Recover of yttrium by precipitation using oxalic acid. • Suitable flowsheet to recover yttrium from fluorescent powder. - Abstract: This work is focused on the recovery of yttrium and zinc from fluorescent powder of cathode ray tube (CRT). Metals are extracted by sulphuric acid in the presence of hydrogen peroxide. Leaching tests are carried out according to a 2{sup 2} full factorial plan and the highest extraction yields for yttrium and zinc equalmore » to 100% are observed under the following conditions: 3 M of sulphuric acid, 10% v/v of H{sub 2}O{sub 2} concentrated solution at 30% v/v, 10% w/w pulp density, 70 °C and 3 h of reaction. Two series of precipitation tests for zinc are carried out: a 2{sup 2} full factorial design and a completely randomized factorial design. In these series the factors investigated are pH of solution during the precipitation and the amount of sodium sulphide added to precipitate zinc sulphide. The data of these tests are used to describe two empirical mathematical models for zinc and yttrium precipitation yields by regression analysis. The highest precipitation yields for zinc are obtained under the following conditions: pH equal to 2–2.5% and 10–12% v/v of Na{sub 2}S concentrated solution at 10% w/v. In these conditions the coprecipitation of yttrium is of 15–20%. Finally further yttrium precipitation experiments by oxalic acid on the residual solutions, after removing of zinc, show that yttrium could be recovered and calcined to obtain the final product as yttrium oxide. The achieved results allow to propose a CRT recycling process based on leaching of fluorescent powder from cathode ray tube and recovery of yttrium oxide after removing of zinc by precipitation. The final recovery of yttrium is 75–80%.« less

Joint Common Architecture Demonstration (JCA Demo) Final Report

DTIC Science & Technology

2016-07-28

approach for implementing open systems [16], formerly known as the Modular Open Systems Approach (MOSA). OSA is a business and technical strategy to... TECHNICAL REPORT RDMR-AD-16-01 JOINT COMMON ARCHITECTURE DEMONSTRATION (JCA DEMO) FINAL REPORT Scott A. Wigginton... Modular Avionics .......................................................................... 5 E. Model-Based Engineering

Molecular mechanisms underlying osteoarthritis development: Notch and NF-κB.

PubMed

Saito, Taku; Tanaka, Sakae

2017-05-15

Osteoarthritis (OA) is a multi-factorial and highly prevalent joint disorder worldwide. Since the establishment of murine surgical knee OA models in 2005, many of the key molecules and signalling pathways responsible for OA development have been identified. Here we review the roles of two multi-functional signalling pathways in OA development: Notch and nuclear factor kappa-light-chain-enhancer of activated B cells. Previous studies have identified various aspects of articular chondrocyte regulation by these pathways. However, comprehensive understanding of the molecular networks regulating articular cartilage homeostasis and OA pathogenesis is needed.

Design and evaluation of high strength concrete for girders : final report.

DOT National Transportation Integrated Search

1980-05-01

The scope of the study was to make concrete mixes in the laboratory using a partial factorial, with three cement contents, two coarse aggregates and three fine-to-coarse aggregate ratios. The mixes showing the best properties and highest compressive ...

Medicare Program; Comprehensive Care for Joint Replacement Payment Model for Acute Care Hospitals Furnishing Lower Extremity Joint Replacement Services. Final rule.

PubMed

2015-11-24

This final rule implements a new Medicare Part A and B payment model under section 1115A of the Social Security Act, called the Comprehensive Care for Joint Replacement (CJR) model, in which acute care hospitals in certain selected geographic areas will receive retrospective bundled payments for episodes of care for lower extremity joint replacement (LEJR) or reattachment of a lower extremity. All related care within 90 days of hospital discharge from the joint replacement procedure will be included in the episode of care. We believe this model will further our goals in improving the efficiency and quality of care for Medicare beneficiaries with these common medical procedures.

Summary of the 2006 use of a notched wedge joint in Connecticut pilot projects : final report.

DOT National Transportation Integrated Search

2008-05-14

Performance of hot mix asphalt longitudinal joints has been an item of increasing scrutiny in Connecticut. The traditional butt joint has typically been the method used in Connecticut. These joints have been reportedly opening up creating a longitudi...

Comprehensive Care for Joint Replacement Model (CJR); Delay of Effective Date. Final rule; delay of effective date.

PubMed

2017-05-19

This final rule finalizes May 20, 2017 as the effective date of the final rule titled "Advancing Care Coordination Through Episode Payment Models (EPMs); Cardiac Rehabilitation Incentive Payment Model; and Changes to the Comprehensive Care for Joint Replacement Model (CJR)" originally published in the January 3, 2017 Federal Register. This final rule also finalizes a delay of the applicability date of the regulations at 42 CFR part 512 from July 1, 2017 to January 1, 2018 and delays the effective date of the specific CJR regulations listed in the DATES section from July 1, 2017 to January 1, 2018.

20 CFR 901.51 - Decision of the Joint Board.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Decision of the Joint Board. 901.51 Section 901.51 Employees' Benefits JOINT BOARD FOR THE ENROLLMENT OF ACTUARIES REGULATIONS GOVERNING THE... final decision. In making its decision the Joint Board will review the record of such portions thereof...

Sample size requirements for separating out the effects of combination treatments: Randomised controlled trials of combination therapy vs. standard treatment compared to factorial designs for patients with tuberculous meningitis

PubMed Central

2011-01-01

Background In certain diseases clinical experts may judge that the intervention with the best prospects is the addition of two treatments to the standard of care. This can either be tested with a simple randomized trial of combination versus standard treatment or with a 2 × 2 factorial design. Methods We compared the two approaches using the design of a new trial in tuberculous meningitis as an example. In that trial the combination of 2 drugs added to standard treatment is assumed to reduce the hazard of death by 30% and the sample size of the combination trial to achieve 80% power is 750 patients. We calculated the power of corresponding factorial designs with one- to sixteen-fold the sample size of the combination trial depending on the contribution of each individual drug to the combination treatment effect and the strength of an interaction between the two. Results In the absence of an interaction, an eight-fold increase in sample size for the factorial design as compared to the combination trial is required to get 80% power to jointly detect effects of both drugs if the contribution of the less potent treatment to the total effect is at least 35%. An eight-fold sample size increase also provides a power of 76% to detect a qualitative interaction at the one-sided 10% significance level if the individual effects of both drugs are equal. Factorial designs with a lower sample size have a high chance to be underpowered, to show significance of only one drug even if both are equally effective, and to miss important interactions. Conclusions Pragmatic combination trials of multiple interventions versus standard therapy are valuable in diseases with a limited patient pool if all interventions test the same treatment concept, it is considered likely that either both or none of the individual interventions are effective, and only moderate drug interactions are suspected. An adequately powered 2 × 2 factorial design to detect effects of individual drugs would require at least 8-fold the sample size of the combination trial. Trial registration Current Controlled Trials ISRCTN61649292 PMID:21288326

Interactions between cadmium and decabrominated diphenyl ether on blood cells count in rats-Multiple factorial regression analysis.

PubMed

Curcic, Marijana; Buha, Aleksandra; Stankovic, Sanja; Milovanovic, Vesna; Bulat, Zorica; Đukić-Ćosić, Danijela; Antonijević, Evica; Vučinić, Slavica; Matović, Vesna; Antonijevic, Biljana

2017-02-01

The objective of this study was to assess toxicity of Cd and BDE-209 mixture on haematological parameters in subacutely exposed rats and to determine the presence and type of interactions between these two chemicals using multiple factorial regression analysis. Furthermore, for the assessment of interaction type, an isobologram based methodology was applied and compared with multiple factorial regression analysis. Chemicals were given by oral gavage to the male Wistar rats weighing 200-240g for 28days. Animals were divided in 16 groups (8/group): control vehiculum group, three groups of rats were treated with 2.5, 7.5 or 15mg Cd/kg/day. These doses were chosen on the bases of literature data and reflect relatively high Cd environmental exposure, three groups of rats were treated with 1000, 2000 or 4000mg BDE-209/kg/bw/day, doses proved to induce toxic effects in rats. Furthermore, nine groups of animals were treated with different mixtures of Cd and BDE-209 containing doses of Cd and BDE-209 stated above. Blood samples were taken at the end of experiment and red blood cells, white blood cells and platelets counts were determined. For interaction assessment multiple factorial regression analysis and fitted isobologram approach were used. In this study, we focused on multiple factorial regression analysis as a method for interaction assessment. We also investigated the interactions between Cd and BDE-209 by the derived model for the description of the obtained fitted isobologram curves. Current study indicated that co-exposure to Cd and BDE-209 can result in significant decrease in RBC count, increase in WBC count and decrease in PLT count, when compared with controls. Multiple factorial regression analysis used for the assessment of interactions type between Cd and BDE-209 indicated synergism for the effect on RBC count and no interactions i.e. additivity for the effects on WBC and PLT counts. On the other hand, isobologram based approach showed slight antagonism for the effects on RBC and WBC while no interactions were proved for the joint effect on PLT count. These results confirm that the assessment of interactions between chemicals in the mixture greatly depends on the concept or method used for this evaluation. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

[Association between joint of heat and noise and metabolic syndrome in steel workers].

PubMed

Li, Xue; Wang, Chaoyang; Fan, Hongmin; Wang, Xiaokai; Zhang, Meihang; Jia, Chongyan; Chai, Feng; Chen, Yinping; Hu, Bo; Yuan, Juxiang; Dong, Ya'nan; Wang, Jianbo

2015-01-01

To analyze the relationship between joint of heat and noise, and metabolic syndrome in a steel rolling factory workers. A total of 590 steel workers were selected as subjects by cluster sampling method from workers of a steel factory. They were investigated by face to face way with the unified questionnaire which contents included personal information, occupational history, personal history, habits and other factors. Furthermore, height, weight, waist circumference and blood pressure were measured. Referring to the 2005 International Diabetes Federation (IDF) issued by the metabolic syndrome (MS) worldwide uniform definition combines waist diagnosis MS. A database was built by Epidata 3.0 software, and data was analyzed by SPSS 17.0. 571 steel workers were from 22 to 60 years, mean age (41.2 -7.9) years old. The prevalence of metabolic syndrome in steel workers was 17.9%. The prevalence of metabolic syndrome of those who exposed to high temperature was 18.8%, higher than that of those who did not expose to high temperature (5.3%), there was a statistically significant difference (P < 0.05). The prevalence of metabolic syndrome of those who exposed to noise was 20.6%, higher than that of those who did not exposed to noise (14.0%) (P < 0.05). After adjusting for the effects of confounding factors, the prevalence of MS those who exposed to high temperatures and noise is 1.118 times as high as that of those who did not exposed to high temperatures and noise. The combined effects of heat and noise is related to the increasing prevalence of MS of steel workers.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Neuffer, David; Snopok, Pavel; Alexahin, Yuri

A neutrino factory or muon collider requires the capture and cooling of a large number of muons. Scenarios for capture, bunching, phase-energy rotation and initial cooling of μ’s produced from a proton source target have been developed, initially for neutrino factory scenarios. They require a drift section from the target, a bunching section and a Φ-δE rotation section leading into the cooling channel. Important concerns are rf limitations within the focusing magnetic fields and large losses in the transport. The currently preferred cooling channel design is an “HFOFO Snake” configuration that cools both μ + and μ - transversely andmore » longitudinally. Finally, the status of the design is presented and variations are discussed.« less

Cloud-based robot remote control system for smart factory

NASA Astrophysics Data System (ADS)

Wu, Zhiming; Li, Lianzhong; Xu, Yang; Zhai, Jingmei

2015-12-01

With the development of internet technologies and the wide application of robots, there is a prospect (trend/tendency) of integration between network and robots. A cloud-based robot remote control system over networks for smart factory is proposed, which enables remote users to control robots and then realize intelligent production. To achieve it, a three-layer system architecture is designed including user layer, service layer and physical layer. Remote control applications running on the cloud server is developed on Microsoft Azure. Moreover, DIV+ CSS technologies are used to design human-machine interface to lower maintenance cost and improve development efficiency. Finally, an experiment is implemented to verify the feasibility of the program.

Robotics: Past, Present, and Future.

ERIC Educational Resources Information Center

Dunne, Maurice J.

Robots are finally receiving wide-spread attention as a means to realize the goal of automating factories. In the 1960's robot use was limited by unfavorable acquisition and operating costs and the affordable control technology limiting applications to relatively simple jobs. During the 1970's productivity of manufacturing organizations declined…

Pollution control of industrial wastewater from soap and oil industries: a case study.

PubMed

Abdel-Gawad, S; Abdel-Shafy, M

2002-01-01

Industrial wastewater from soap and oil industries represents a heavy pollution source on their receiving water body. This paper studies a case of pollution control at Tanta Soap and Oil Company, Banha Factory, Egypt. The factory production includes soap, edible oil, and animal fodder. About 4,347 m3/day of industrial wastewater effluent was discharged via gravity sewers to the public sewerage system. Most of the effluent was cooling water because the cooling process in the factory was open circle. In spite of the huge quantity of cooling water being disposed of, disposal of wastewater was violating pertinent legislation. Three procedures were used for controlling the pollution at the Banha Factory. Firstly, all open circuit cooling systems were converted to closed circuit thus reducing the quantity of the discharged wastewater down to 767 m3/day. Secondly, the heavily polluted oil and grease (O&G) wastewater from the refinery unit is treated via two gravity oil separator (GOS) units, dissolved air floatation (DAF), and biological units in order to reduce the high levels of O&G, BOD, COD, and SS to the allowable limits. Thirdly, the heavily polluted waste effluent from the 'red water' saponification unit is treated separately by acidification to convert the emulsified fatty acid to free form in order to be separated through an oil separation unit. The effluent is then passed to liming stage to neutralize excess acidity and precipitate some of the dissolved matters. The mixture is finally clarified and the pH is adjusted to the allowable limits. The effluent wastewater from the three processes is collected and mixed in a final equalization tank for discharging effluent to the public sewerage system. The characteristics of the effluent water are very good with respect to the allowable Egyptian limits for discharging effluent to the public sewerage system.

Results and Analysis from Space Suit Joint Torque Testing

NASA Technical Reports Server (NTRS)

Matty, Jennifer E.; Aitchison, Lindsay

2009-01-01

A space suit s mobility is critical to an astronaut s ability to perform work efficiently. As mobility increases, the astronaut can perform tasks for longer durations with less fatigue. The term mobility, with respect to space suits, is defined in terms of two key components: joint range of motion and joint torque. Individually these measures describe the path which in which a joint travels and the force required to move it through that path. Previous space suits mobility requirements were defined as the collective result of these two measures and verified by the completion of discrete functional tasks. While a valid way to impose mobility requirements, such a method does necessitate a solid understanding of the operational scenarios in which the final suit will be performing. Because the Constellation space suit system requirements are being finalized with a relatively immature concept of operations, the Space Suit Element team elected to define mobility in terms of its constituent parts to increase the likelihood that the future pressure garment will be mobile enough to enable a broad scope of undefined exploration activities. The range of motion requirements were defined by measuring the ranges of motion test subjects achieved while performing a series of joint maximizing tasks in a variety of flight and prototype space suits. The definition of joint torque requirements has proved more elusive. NASA evaluated several different approaches to the problem before deciding to generate requirements based on unmanned joint torque evaluations of six different space suit configurations being articulated through 16 separate joint movements. This paper discusses the experiment design, data analysis and results, and the process used to determine the final values for the Constellation pressure garment joint torque requirements.

An Integrated Socio-Environmental Model of Health and Well-Being: a Conceptual Framework Exploring the Joint Contribution of Environmental and Social Exposures to Health and Disease Over the Life Span.

PubMed

Olvera Alvarez, Hector A; Appleton, Allison A; Fuller, Christina H; Belcourt, Annie; Kubzansky, Laura D

2018-06-01

Environmental and social determinants of health often co-occur, particularly among socially disadvantaged populations, yet because they are usually studied separately, their joint effects on health are likely underestimated. Building on converging bodies of literature, we delineate a conceptual framework to address these issues. Previous models provided a foundation for study in this area, and generated research pointing to additional important issues. These include a stronger focus on biobehavioral pathways, both positive and adverse health outcomes, and intergenerational effects. To accommodate the expanded set of issues, we put forward the Integrated Socio-Environmental Model of Health and Well-Being (ISEM), which examines how social and environmental factors combine and potentially interact, via multi-factorial pathways, to affect health and well-being over the life span. We then provide applied examples including the study of how food environments affect dietary behavior. The ISEM provides a comprehensive, theoretically informed framework to guide future research on the joint contribution of social and environmental factors to health and well-being across the life span.

Perceptions of issues relating to exercise and joint health in rheumatoid arthritis: a UK-based questionnaire study.

PubMed

Law, Rebecca-Jane; Markland, David A; Jones, Jeremy G; Maddison, Peter J; Thom, Jeanette M

2013-09-01

This questionnaire study investigated the perceptions of rheumatoid arthritis (RA) patients across the UK in relation to exercise and joint health. The validity of the measure was also assessed. Members of the National Rheumatoid Arthritis Society (NRAS) with self-reported RA completed the questionnaire online. Items related to five factors that emerged from previous qualitative research. Participants responded using a five-point Likert-style scale (strongly disagree to strongly agree). The International Physical Activity Questionnaire (IPAQ) assessed physical activity. The model was tested using confirmatory factor analysis (LISREL 8.8); statistical analyses were conducted using the Statistical Package for the Social Sciences (SPSS). A total of 247 responses were collected over 47 days (88% females; age: 18-77 years; disease duration: <1-51 years). Acceptable factorial validity was revealed (Satorra-Bentler χ(2)  = 774.47, df = 454, p < 0.001, root mean squared error of approximation (RMSEA) = 0.05, 90% confidence interval RMSEA = 0.05-0.06, comparative fit index = 0.94, standardized root mean square residual = 0.09), with the following factor endorsements: 'Health professionals show exercise knowledge' (19%); 'Knowing what exercise should be done' (43%); 'Having to exercise because it is helpful' (72%); 'Worry about causing harm to joints' (44%); and 'Not wanting to exercise as joints hurt' (52%). Patient concerns about joint pain, joint harm and how to exercise were significantly associated with lower physical activity (p < 0.05). These results confirm that patients perceive exercise as beneficial. However, concerns about how to exercise, joint pain, causing harm to joints and a perceived lack of exercise knowledge among health professionals remain. Addressing these concerns may have implications for increasing physical activity within the RA population. Copyright © 2012 John Wiley & Sons, Ltd.

Research on Joint Sealant Materials to Improve Installation and Performance : Final Report

DOT National Transportation Integrated Search

2017-12-01

The objectives of this project were to 1) identify failure modes and their mechanisms in joint seals in Texas, and to 2) identify what needs to be done to minimize the failures and improve joint seal performance. To achieve these objectives efficient...

Self management, joint protection and exercises in hand osteoarthritis: a randomised controlled trial with cost effectiveness analyses

PubMed Central

2011-01-01

Background There is limited evidence for the clinical and cost effectiveness of occupational therapy (OT) approaches in the management of hand osteoarthritis (OA). Joint protection and hand exercises have been proposed by European guidelines, however the clinical and cost effectiveness of each intervention is unknown. This multicentre two-by-two factorial randomised controlled trial aims to address the following questions: • Is joint protection delivered by an OT more effective in reducing hand pain and disability than no joint protection in people with hand OA in primary care? • Are hand exercises delivered by an OT more effective in reducing hand pain and disability than no hand exercises in people with hand OA in primary care? • Which of the four management approaches explored within the study (leaflet and advice, joint protection, hand exercise, or joint protection and hand exercise combined) provides the most cost-effective use of health care resources Methods/Design Participants aged 50 years and over registered at three general practices in North Staffordshire and Cheshire will be mailed a health survey questionnaire (estimated mailing sample n = 9,500). Those fulfilling the eligibility criteria on the health survey questionnaire will be invited to attend a clinical assessment to assess for the presence of hand or thumb base OA using the ACR criteria. Eligible participants will be randomised to one of four groups: leaflet and advice; joint protection (looking after your joints); hand exercises; or joint protection and hand exercises combined (estimated n = 252). The primary outcome measure will be the OARSI/OMERACT responder criteria combining hand pain and disability (measured using the AUSCAN) and global improvement, 6 months post-randomisation. Secondary outcomes will also be collected for example pain, functional limitation and quality of life. Outcomes will be collected at baseline and 3, 6 and 12 months post-randomisation. The main analysis will be on an intention to treat basis and will assess the clinical and cost effectiveness of joint protection and hand exercises for managing hand OA. Discussion The findings will improve the cost-effective evidence based management of hand OA. Trial registration identifier: ISRCTN33870549 PMID:21745357

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heaney, Mike

Statistically designed experiments can save researchers time and money by reducing the number of necessary experimental trials, while resulting in more conclusive experimental results. Surprisingly, many researchers are still not aware of this efficient and effective experimental methodology. As reported in a 2013 article from Chemical & Engineering News, there has been a resurgence of this methodology in recent years (http://cen.acs.org/articles/91/i13/Design-Experiments-Makes-Comeback.html?h=2027056365). This presentation will provide a brief introduction to statistically designed experiments. The main advantages will be reviewed along with the some basic concepts such as factorial and fractional factorial designs. The recommended sequential approach to experiments will be introducedmore » and finally a case study will be presented to demonstrate this methodology.« less

Measurement of the absolute branching ratio of the K+ →π+π-π+ (γ) decay with the KLOE detector

NASA Astrophysics Data System (ADS)

Babusci, D.; Balwierz-Pytko, I.; Bencivenni, G.; Bloise, C.; Bossi, F.; Branchini, P.; Budano, A.; Caldeira Balkeståhl, L.; Ceradini, F.; Ciambrone, P.; Curciarello, F.; Czerwiński, E.; Danè, E.; De Leo, V.; De Lucia, E.; De Robertis, G.; De Santis, A.; De Simone, P.; Di Cicco, A.; Di Domenico, A.; Di Salvo, R.; Domenici, D.; Erriquez, O.; Fanizzi, G.; Fantini, A.; Felici, G.; Fiore, S.; Franzini, P.; Gajos, A.; Gauzzi, P.; Giardina, G.; Giovannella, S.; Graziani, E.; Happacher, F.; Heijkenskjöld, L.; Höistad, B.; Johansson, T.; Kamińska, D.; Krzemien, W.; Kupsc, A.; Lee-Franzini, J.; Loddo, F.; Loffredo, S.; Mandaglio, G.; Martemianov, M.; Martini, M.; Mascolo, M.; Messi, R.; Miscetti, S.; Morello, G.; Moricciani, D.; Moskal, P.; Palladino, A.; Passeri, A.; Patera, V.; Prado Longhi, I.; Ranieri, A.; Santangelo, P.; Sarra, I.; Schioppa, M.; Sciascia, B.; Silarski, M.; Tortora, L.; Venanzoni, G.; Wiślicki, W.; Wolke, M.; KLOE/KLOE-2 Collaboration

2014-11-01

The absolute branching ratio of the K+ →π+π-π+ (γ) decay, inclusive of final-state radiation, has been measured using ∼17 million tagged K+ mesons collected with the KLOE detector at DAΦNE, the Frascati ϕ-factory. The result is:

Individual Differences in Learning and Memory. Final Report.

ERIC Educational Resources Information Center

Wimer, Richard E.

A battery of behavioral tests yielding 79 measures, many of which were presumably related to learning and memory, was administered to house mice of seven inbred strains. An analysis of the factorial structure indicated that the two principal and most pervasive factors underlying performance on the battery involved the initiation and maintenance of…

75 FR 1336 - First Administrative Review of Certain Polyester Staple Fiber From the People's Republic of China...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-11

... System. Jianxin Fuda Chemical Fibre Factory. Comment 6: Correction of Name in Federal Register Notice... of Certain Polyester Staple Fiber From the People's Republic of China: Final Results of Antidumping... duty order on certain polyester staple fiber (``PSF'') from the People's Republic of China (``PRC...

VISUAL AND AUDIO PRESENTATION IN MACHINE PROGRAMED INSTRUCTION. FINAL REPORT.

ERIC Educational Resources Information Center

ALLEN, WILLIAM H.

THIS STUDY WAS PART OF A LARGER RESEARCH PROGRAM AIMED TOWARD DEVELOPMENT OF PARADIGMS OF MESSAGE DESIGN. OBJECTIVES OF THREE PARALLEL EXPERIMENTS WERE TO EVALUATE INTERACTIONS OF PRESENTATION MODE, PROGRAM TYPE, AND CONTENT AS THEY AFFECT LEARNER CHARACTERISTICS. EACH EXPERIMENT USED 18 TREATMENTS IN A FACTORIAL DESIGN WITH RANDOMLY SELECTED…

Does Kinesiology tape counter exercise-related impairments of balance in the elderly?

PubMed

Hosp, Simona; Csapo, Robert; Heinrich, Dieter; Hasler, Michael; Nachbauer, Werner

2018-05-01

Maintaining balance is an essential requirement for the performance of daily tasks and sporting activities, particularly in older adults to prevent falls and associated injuries. Kinesiology tape has gained great popularity in sports and is frequently used as a tool for performance enhancement. However, there is little research investigating its influence on balance. The purpose of this study was to evaluate the effect of Kinesiology tape on dynamic balance, postural stability and knee proprioception after physical activity in healthy, older adults. Twelve physically active, healthy men aged 63-77 years performed the test on two separate days, with and without Kinesiology tape at the knee joint (prospective intervention with cross-over design). Dynamic balance during an obstacle-crossing task, postural stability in a single-leg stance test, and knee joint position sense as a measure of proprioception were examined before and after 30 min of downhill walking on a treadmill. The influences of taping condition and physical activity on all parameters were statistically tested using factorial ANOVAs. Factorial ANOVA revealed significant time × taping condition interaction effects on all performance parameters (p < 0.05), indicating that the exercise-related changes in dynamic balance, postural stability and knee proprioception differed between the two taping conditions. The deterioration of performance was always greater when no tape was used. This study demonstrated that physical exercise significantly deteriorated dynamic balance, postural stability and knee proprioception in older men. These effects can be attenuated through the usage of Kinesiology tape. By preventing exercise-related impairments of balance, Kinesiology tape might help reduce the risk of sports-associated falls and associated injuries. Copyright © 2018 Elsevier B.V. All rights reserved.

Summary and recommendations. [reduced gravitational effects on materials manufactured in space

NASA Technical Reports Server (NTRS)

1975-01-01

An economic analysis using econometric and cost benefit analysis techniques was performed to determine the feasibility of space processing of certain products. The overall objectives of the analysis were (1) to determine specific products or processes uniquely connected with space manufacturing, (2) to select a specific product or process from each of the areas of semiconductors, metals, and biochemicals, and (3) to determine the overall price/cost structure of each product or process considered. The economic elements of the analysis involved a generalized decision making format for analyzing space manufacturing, a comparative cost study of the selected processes in space vs. earth manufacturing, and a supply and demand study of the economic relationships of one of the manufacturing processes. Space processing concepts were explored. The first involved the use of the shuttle as the factory with all operations performed during individual flights. The second concept involved a permanent unmanned space factory which would be launched separately. The shuttle in this case would be used only for maintenance and refurbishment. Finally, some consideration was given to a permanent manned space factory.

Status of the nuSTORM Facility and a Possible Extension for Long-Baseline $$\

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bross, Alan D.; Liu, Ao; Lagrange, Jean-Baptiste

2015-11-03

Neutrino beams produced from the decay of muons in a racetrack-like decay ring (the so called Neutrino Factory) provide a powerful way to study neutrino oscillation physics and, in addition, provide unique beams for neutrino interaction studies. The Neutrinos from STORed Muons (nuSTORM) facility uses a neutrino factory-like design. Due to the particular nature of nuSTORM, it can also provide an intense, very pure, muon neutrino beam from pion decay. This so-called “Neo-conventional" muon neutrino beam from nuSTORM makes nuSTORM a hybrid neutrino factory. In this paper we describe the facility and give a detailed description of the neutrino beammore » fluxes that are available and the precision to which these fluxes can be determined. We then present sensitivity plots that indicated how well the facility can perform for short-baseline oscillation searches and show its potential for a neutrino interaction physics program. Finally, we comment on the performance potential of the "Neo-conventional" muon neutrino beam optimized for long- baseline neutrino-oscillation physics.« less

Joint Technical Architecture for Robotic Systems (JTARS)-Final Report

NASA Technical Reports Server (NTRS)

Bradley, Arthur T.; Holloway, Sidney E., III

2006-01-01

This document represents the final report for the Joint Technical Architecture for Robotic Systems (JTARS) project, funded by the Office of Exploration as part of the Intramural Call for Proposals of 2005. The project was prematurely terminated, without review, as part of an agency-wide realignment towards the development of a Crew Exploration Vehicle (CEV) and meeting the near-term goals of lunar exploration.

Medicare Program; Cancellation of Advancing Care Coordination Through Episode Payment and Cardiac Rehabilitation Incentive Payment Models; Changes to Comprehensive Care for Joint Replacement Payment Model: Extreme and Uncontrollable Circumstances Policy for the Comprehensive Care for Joint Replacement Payment Model. Final rule; interim final rule with comment period.

PubMed

2017-12-01

This final rule cancels the Episode Payment Models (EPMs) and Cardiac Rehabilitation (CR) Incentive Payment Model and rescinds the regulations governing these models. It also implements certain revisions to the Comprehensive Care for Joint Replacement (CJR) model, including: Giving certain hospitals selected for participation in the CJR model a one-time option to choose whether to continue their participation in the model; technical refinements and clarifications for certain payment, reconciliation and quality provisions; and a change to increase the pool of eligible clinicians that qualify as affiliated practitioners under the Advanced Alternative Payment Model (Advanced APM) track. An interim final rule with comment period is being issued in conjunction with this final rule in order to address the need for a policy to provide some flexibility in the determination of episode costs for providers located in areas impacted by extreme and uncontrollable circumstances.

Networking Sensors for Information Dominance - Joint Signal Processing and Communication Design

DTIC Science & Technology

2012-01-01

2012 4. TITLE AND SUBTITLE NETWORKING SENSORS FOR INFORMATION DOMINANCE - JOINT SIGNAL PROCESSING AND COMMUNICATION DESIGN, Final Report for FA9550...Rev. 2-89) Prescribed by ANSI Std. Z39-18 298-102 Public A AFRL-OSR-VA-TR-2012-0729 NETWORKING SENSORS FOR INFORMATION DOMINANCE - JOINT

RSRM Nozzle-to-Case Joint J-leg Development

NASA Technical Reports Server (NTRS)

Albrechtsen, Kevin U.; Eddy, Norman F.; Ewing, Mark E.; McGuire, John R.

2003-01-01

Since the beginning of the Space Shuttle Reusable Solid Rocket Motor (RSRM) program, nozzle-to-case joint polysulfide adhesive gas paths have occurred on several flight motors. These gas paths have allowed hot motor gases to reach the wiper O-ring. Even though these motors continue to fly safely with this condition, a desire was to reduce such occurrences. The RSRM currently uses a J-leg joint configuration on case field joints and igniter inner and outer joints. The J-leg joint configuration has been successfully demonstrated on numerous RSRM flight and static test motors, eliminating hot gas intrusion to the critical O-ring seals on these joints. Using the proven technology demonstrated on the case field joints and igniter joints, a nozzle-to-case joint J-leg design was developed for implementation on RSRM flight motors. This configuration provides an interference fit with nozzle fixed housing phenolics at assembly, with a series of pressurization gaps incorporated outboard of the joint mating surface to aid in joint pressurization and to eliminate any circumferential flow in this region. The joint insulation is bonded to the nozzle phenolics using the same pressure sensitive adhesive used in the case field joints and igniter joints. An enhancement to the nozzle-to-case joint J-leg configuration is the implementation of a carbon rope thermal barrier. The thermal barrier is located downstream of the joint bondline and is positioned within the joint in a manner where any hot gas intrusion into the joint passes through the thermal barrier, reducing gas temperatures to a level that would not affect O-rings downstream of the thermal barrier. This paper discusses the processes used in reaching a final nozzle-to-case joint J-leg design, provides structural and thermal results in support of the design, and identifies fabrication techniques and demonstrations used in arriving at the final configuration.

Overcoming Space and Time Disadvantages in Joint Theater Missile Defense

DTIC Science & Technology

2002-02-04

Disadvantages in Joint Theater Missile Defense (Unclassified) 9. Personal Authors: Major Robert Kelley 10.Type of Report: FINAL 11. Date of Report...Classification of This Page Unclassified NAVAL WAR COLLEGE Newport, RI Overcoming Space and Time Disadvantages in Joint Theater Missile Defense By Robert...Covered (from... to) - Title and Subtitle Overcoming Space and Time Disadvantages in Joint Theater Missile Defense Contract Number Grant Number

Minimally invasive reconstruction of acute type IV and Type V acromioclavicular separations.

PubMed

Katsenis, Dimitris L; Stamoulis, Dimitris; Begkas, Dimitris; Tsamados, Stamatis

2015-04-01

The goal of this study was to evaluate the midterm radiologic, clinical, and functional results of the early reconstruction of the severe acromioclavicular joint dislocation using the flipptack fixation button technique. Between December 2006 and December 2009, one hundred thirty-five consecutive patients with acromioclavicular joint separations were admitted to the authors' institution. Fifty patients were included in the study. According to Rockwood classification, 29 (58%) dislocations were type IV and 21 (42%) were type V. Surgery was performed at an average of 4.2 days (range, 0-12 days) after dislocation. All dislocations were treated with the flipptack fixation button technique. All patients were evaluated at a final postoperative follow-up of 42 months (range, 36-49 months). The clinical outcome was assessed using the Constant score. The functional limitation was assessed using the bother index of the short Musculoskeletal Function Assessment. Radiographs taken immediately postoperatively and at the final follow-up assessed acromioclavicular joint reduction, coracoclavicular distance, and joint arthrosis. At the final follow-up, mean Constant score was 93.04 (range, 84-100). The average (±SD) short Musculoskeletal Function Assessment bother index was 20.88±8.95 (range, 2.0-49). No statistically significant difference was found between the acromioclavicular joint dislocation type and the clinical result (P=.227; chi-square, 6.910, Kruskal Wallis test). The regression of the coracoclavicular distance at final follow-up was not statistically significant (P=.276; chi-square, 6.319, Kruskal Wallis test). The flipptack fixation button technique is an effective alternative for the treatment of severe acromioclavicular joint dislocation. Because all objectives of the treatment were obtained, the results do not deteriorate over time. Copyright 2015, SLACK Incorporated.

Augmented Reality-Guided Lumbar Facet Joint Injections.

PubMed

Agten, Christoph A; Dennler, Cyrill; Rosskopf, Andrea B; Jaberg, Laurenz; Pfirrmann, Christian W A; Farshad, Mazda

2018-05-08

The aim of this study was to assess feasibility and accuracy of augmented reality-guided lumbar facet joint injections. A spine phantom completely embedded in hardened opaque agar with 3 ring markers was built. A 3-dimensional model of the phantom was uploaded to an augmented reality headset (Microsoft HoloLens). Two radiologists independently performed 20 augmented reality-guided and 20 computed tomography (CT)-guided facet joint injections each: for each augmented reality-guided injection, the hologram was manually aligned with the phantom container using the ring markers. The radiologists targeted the virtual facet joint and tried to place the needle tip in the holographic joint space. Computed tomography was performed after each needle placement to document final needle tip position. Time needed from grabbing the needle to final needle placement was measured for each simulated injection. An independent radiologist rated images of all needle placements in a randomized order blinded to modality (augmented reality vs CT) and performer as perfect, acceptable, incorrect, or unsafe. Accuracy and time to place needles were compared between augmented reality-guided and CT-guided facet joint injections. In total, 39/40 (97.5%) of augmented reality-guided needle placements were either perfect or acceptable compared with 40/40 (100%) CT-guided needle placements (P = 0.5). One augmented reality-guided injection missed the facet joint space by 2 mm. No unsafe needle placements occurred. Time to final needle placement was substantially faster with augmented reality guidance (mean 14 ± 6 seconds vs 39 ± 15 seconds, P < 0.001 for both readers). Augmented reality-guided facet joint injections are feasible and accurate without potentially harmful needle placement in an experimental setting.

Unitization of oil and gas fields in Texas. A study of legislative, administrative, and judicial policies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weaver, J.L.

1986-01-01

In the 1970s, the long lines of cars at gasoline stations, the blackouts, and the school and factory closings announced to the public that the United States had an ''energy crisis.'' In response, an outpouring of state and federal legislation sought to lessen the effects of the oil and gas shortages and to prevent their recurrence. By 1985, every oil- and gas-producing state but Texas has passed a compulsory unitization statute. ''Unitization'' is the joint, coordinated operation of all, or at least a large part, of an oil or gas reservoir by the owners of the separate tracts overlying themore » reservoir; only by such joint endeavors can the many owners of interests in oil and gas fields operate efficiently to recover as much as possible at the lowest cost. In this book, Jacqueline Lang Weaver explains why Texas failed to enact such a statute--and how Texas has achieved a substantial degree of unitization nonetheless.« less

Unilateral pseudogynecomastia: an occupational hazard in manual metal-pressing factories?

PubMed

Spyropoulou, Georgia-Alexandra; Karamatsoukis, Stavros; Foroglou, Pericles

2011-04-01

Five cases of unilateral occupation-related pseudogynecomastia are presented. All the patients in these cases worked in the same metal-pressing factory. One patient with grade 4 unilateral gynecomastia in the right breast presented to the authors' outpatient department asking persistently for surgery. He also reported that all his male colleagues working in the same business (a total of 5) had different degrees of unilateral gynecomastia. Their line of work involved holding a long round rod under the axilla and then pressing the distal end of it firmly against a spinning metal plate. The patient underwent a superior pedicle breast reduction, with 1,800 ml of tissue removed from his right breast. Unfortunately, the patient experienced partial nipple loss. However, he was satisfied with the final result, and good symmetry was achieved. All five patients who worked in the same metal-pressing factory presented with unilateral gynecomastia and were examined in our department. Their average age was 51.4 years. All the patients had normal hormonal and biochemical status, and the results of screening for toxins and heavy metal exposure were negative. All the patients were heavy smokers. At examination, none of the patients had nipple discharge or retraction, skin changes, galactorrhea, or lymphadenopathy. Examination showed one patient with grade 4, three patients had grade 2, and one patient with grade 1 unilateral gynecomastia. The authors believe that gynecomastia may be considered an occupational risk in analogous metal-pressing factories because all the workers in this factory presented with some degree of unilateral gynecomastia. However, they emphasize that this may simply be an observational phenomenon without a true cause and effect relationship.

Space suit glove design with advanced metacarpal phalangeal joints and robotic hand evaluation.

PubMed

Southern, Theodore; Roberts, Dustyn P; Moiseev, Nikolay; Ross, Amy; Kim, Joo H

2013-06-01

One area of space suits that is ripe for innovation is the glove. Existing models allow for some fine motor control, but the power grip--the act of grasping a bar--is cumbersome due to high torque requirements at the knuckle or metacarpal phalangeal joint (MCP). This area in particular is also a major source of complaints of pain and injury as reported by astronauts. This paper explores a novel fabrication and patterning technique that allows for more freedom of movement and less pain at this crucial joint in the manned space suit glove. The improvements are evaluated through unmanned testing, manned testing while depressurized in a vacuum glove box, and pressurized testing with a robotic hand. MCP joint flex score improved from 6 to 6.75 (out of 10) in the final glove relative to the baseline glove, and torque required for flexion decreased an average of 17% across all fingers. Qualitative assessments during unpressurized and depressurized manned testing also indicated the final glove was more comfortable than the baseline glove. The quantitative results from both human subject questionnaires and robotic torque evaluation suggest that the final iteration of the glove design enables flexion at the MCP joint with less torque and more comfort than the baseline glove.

Effects of local treatment with and without sensorimotor and balance exercise in individuals with neck pain: protocol for a randomized controlled trial.

PubMed

Sremakaew, Munlika; Jull, Gwendolen; Treleaven, Julia; Barbero, Marco; Falla, Deborah; Uthaikhup, Sureeporn

2018-02-13

Impaired cervical joint position sense and balance are associated with neck pain. Specific therapeutic exercise and manual therapy are effective for improving neck pain and functional ability but their effects on joint position sense and balance impairments remain uncertain. Changes in the joint position sense and balance may need to be addressed specifically. The primary objective is to investigate the most effective interventions to improve impaired cervical joint position sense and balance in individuals with neck pain. The secondary objective is to assess the effectiveness of the interventions on pain intensity and disability, pain location, dizziness symptoms, cervical range of motion, gait speed, functional ability, treatment satisfaction and quality of life. A 2 × 2 factorial, single blind RCT with immediate, short- and long-term follow-ups. One hundred and sixty eight participants with neck pain with impaired joint position sense and balance will be recruited into the trial. Participants will be randomly allocated to one of four intervention groups: i) local neck treatment, ii) local treatment plus tailored sensorimotor exercises, iii) local treatment plus balance exercises, and iv) local treatment plus sensorimotor and balance exercises. Participants receive two treatments for 6 weeks. Primary outcomes are postural sway and cervical joint position error. Secondary outcomes include gait speed, dizziness intensity, neck pain intensity, neck disability, pain extent and location, cervical range of motion, functional ability, perceived benefit, and quality of life. Assessment will be measured at baseline, immediately after treatment and at 3, 6, 12 month-follow ups. Neck pain is one of the major causes of disability. Effective treatment must address not only the symptoms but the dysfunctions associated with neck pain. This trial will evaluate the effectiveness of interventions for individuals with neck pain with impaired cervical joint position sense and balance. This trial will impact on clinical practice by providing evidence towards optimal and efficient management. ClinicalTrials.gov ( NCT03149302 ). May 10, 2017.

Protective Clothing as a Factor in the Dust Hazard of Potters

PubMed Central

Bloor, W. A.; Dinsdale, A.

1962-01-01

Investigations into the factors affecting dust concentrations in the breathing zone of pottery operatives have shown that cotton overalls constitute a serious source of dust. Attempts to overcome this difficulty by treatment of the material were not successful, so other types of materials were investigated. Terylene was found to have outstandingly desirable properties; types of “terylene” material and designs of clothing were defined. Factory tests showed that with this new protective clothing reductions of up to 65% in breathing zone dust concentrations were achieved. This type of clothing is now being officially recommended by the Joint Standing Committee for the Pottery Industry. Images PMID:13971816

Evaluation of RSRM case hardware fretting concerns

NASA Technical Reports Server (NTRS)

Swauger, Thomas R.

1990-01-01

Fretting corrosion was first noted on Shuttle flight STS-26. This flight was the first usage of the Redesigned Solid Rocket Motor (RSRM). The occurrence of fretting has since been observed on both the field and factory joints of the RSRM. Fretting is a form of corrosion that occurs at the interface between contacting, highly loaded, metal surfaces when exposed to slight relative vibratory motions. The engineering effort performed to evaluate the effect of fretting on the RSRM case hardware is summarized. Based on the results of this evaluation, several conclusions were made concerning flight safety. Also, recommendations were made concerning trending the effects of multiple generations of fretting damage.

Technology, Division of Labor and Alienation From Work. Final Report.

ERIC Educational Resources Information Center

Shepard, Jon M.

This study investigated the theory that a worker's relationship to technology instills in him identifiable attitudes about work. Using samples of office workers from a bank and five insurance companies, and samples of factory workers from the oil refining and automobile industries, a total of 1,888 workers were divided into (1) office and factory…

78 FR 58273 - Hardwood and Decorative Plywood From the People's Republic of China: Final Determination of Sales...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-23

...\\ Jiangyang Group......... 62.55 Anhui Tiansen Trading Co., Ltd... Linyi City Fei County 59.46 Jianxin Boards... Co., Ltd. Bergey (Tianjin) International Suqian City Santai Wood 59.46 Co., Ltd. Industry Co., Ltd...., Ltd. Deqing Dajiang Import And Export Linyi City Lanshan 59.46 Co., Ltd. District Qifeng Wood Factory...

78 FR 52679 - Safety Standard for Cigarette Lighters; Adjusted Customs Value for Cigarette Lighters

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-26

... Customs Value for Cigarette Lighters AGENCY: Consumer Product Safety Commission. ACTION: Final rule... refillable lighters that use butane or similar fuels and have a Customs Value or ex-factory price below a threshold value (initially set at $2.00 in 1993). The standard provides that the initial $2.00 value adjusts...

The Influence of Accreditation on the Sustainability of Organizations with the Brazilian Accreditation Methodology

PubMed Central

de Paiva, Anderson Paulo

2018-01-01

This research evaluates the influence of the Brazilian accreditation methodology on the sustainability of the organizations. Critical factors for implementing accreditation were also examined, including measuring the relationships established between these factors in the organization sustainability. The present study was developed based on the survey methodology applied in the organizations accredited by ONA (National Accreditation Organization); 288 responses were received from the top level managers. The analysis of quantitative data of the measurement models was made with factorial analysis from principal components. The final model was evaluated from the confirmatory factorial analysis and structural equation modeling techniques. The results from the research are vital for the definition of factors that interfere in the accreditation processes, providing a better understanding for accredited organizations and for Brazilian accreditation. PMID:29599939

Advancing metabolic engineering through systems biology of industrial microorganisms.

PubMed

Dai, Zongjie; Nielsen, Jens

2015-12-01

Development of sustainable processes to produce bio-based compounds is necessary due to the severe environmental problems caused by the use of fossil resources. Metabolic engineering can facilitate the development of highly efficient cell factories to produce these compounds from renewable resources. The objective of systems biology is to gain a comprehensive and quantitative understanding of living cells and can hereby enhance our ability to characterize and predict cellular behavior. Systems biology of industrial microorganisms is therefore valuable for metabolic engineering. Here we review the application of systems biology tools for the identification of metabolic engineering targets which may lead to reduced development time for efficient cell factories. Finally, we present some perspectives of systems biology for advancing metabolic engineering further. Copyright © 2015 Elsevier Ltd. All rights reserved.

Joint Instability and Osteoarthritis

PubMed Central

Blalock, Darryl; Miller, Andrew; Tilley, Michael; Wang, Jinxi

2015-01-01

Joint instability creates a clinical and economic burden in the health care system. Injuries and disorders that directly damage the joint structure or lead to joint instability are highly associated with osteoarthritis (OA). Thus, understanding the physiology of joint stability and the mechanisms of joint instability-induced OA is of clinical significance. The first section of this review discusses the structure and function of major joint tissues, including periarticular muscles, which play a significant role in joint stability. Because the knee, ankle, and shoulder joints demonstrate a high incidence of ligament injury and joint instability, the second section summarizes the mechanisms of ligament injury-associated joint instability of these joints. The final section highlights the recent advances in the understanding of the mechanical and biological mechanisms of joint instability-induced OA. These advances may lead to new opportunities for clinical intervention in the prevention and early treatment of OA. PMID:25741184

Joint instability and osteoarthritis.

PubMed

Blalock, Darryl; Miller, Andrew; Tilley, Michael; Wang, Jinxi

2015-01-01

Joint instability creates a clinical and economic burden in the health care system. Injuries and disorders that directly damage the joint structure or lead to joint instability are highly associated with osteoarthritis (OA). Thus, understanding the physiology of joint stability and the mechanisms of joint instability-induced OA is of clinical significance. The first section of this review discusses the structure and function of major joint tissues, including periarticular muscles, which play a significant role in joint stability. Because the knee, ankle, and shoulder joints demonstrate a high incidence of ligament injury and joint instability, the second section summarizes the mechanisms of ligament injury-associated joint instability of these joints. The final section highlights the recent advances in the understanding of the mechanical and biological mechanisms of joint instability-induced OA. These advances may lead to new opportunities for clinical intervention in the prevention and early treatment of OA.

The Software Engineering Laboratory: An operational software experience factory

NASA Technical Reports Server (NTRS)

Basili, Victor R.; Caldiera, Gianluigi; Mcgarry, Frank; Pajerski, Rose; Page, Gerald; Waligora, Sharon

1992-01-01

For 15 years, the Software Engineering Laboratory (SEL) has been carrying out studies and experiments for the purpose of understanding, assessing, and improving software and software processes within a production software development environment at NASA/GSFC. The SEL comprises three major organizations: (1) NASA/GSFC, Flight Dynamics Division; (2) University of Maryland, Department of Computer Science; and (3) Computer Sciences Corporation, Flight Dynamics Technology Group. These organizations have jointly carried out several hundred software studies, producing hundreds of reports, papers, and documents, all of which describe some aspect of the software engineering technology that was analyzed in the flight dynamics environment at NASA. The studies range from small, controlled experiments (such as analyzing the effectiveness of code reading versus that of functional testing) to large, multiple project studies (such as assessing the impacts of Ada on a production environment). The organization's driving goal is to improve the software process continually, so that sustained improvement may be observed in the resulting products. This paper discusses the SEL as a functioning example of an operational software experience factory and summarizes the characteristics of and major lessons learned from 15 years of SEL operations.

[Risk assessment and countermeasure of BTEX in pesticide factory].

PubMed

Pang, Bo; Wang, Tie-Yu; Du, Li-Yu; Tan, Bing; Zhu, Zhao-Yun; Lu, Yong-Long

2013-07-01

BTEX are important environmental pollutants, harmful to human through respiratory inhalation, digestive tract and skin contact, and also have teratogenic, mutagenic and carcinogenic effects. BTEX were detected in multi-media to identify their distributions and assess their human health risk in a pesticide factory in Hebei province. Purge and trap GC-MS, adsorption/thermal desorption GC chromatography and the health risk assessment model were applied, and corresponding management measures were proposed. The results showed that BTEX existed in soil, dust, air, groundwater and wastewater. The concentration of BTEX in dust of the production area was 7.33 mg x kg(-1), in particular the concentration of toluene was 5.64 mg x kg(-1), exceeding the Canadian industrial land standard. Building three scenarios for working more than 10 years, 20 years and 30 years, the total non-carcinogens index was 4.19 x10(-3), 8.25 x 10(-3) and 1.22 x 10(-2), respectively, all lower than 1; the carcinogens index of benzene was 1.70 x 10(-7), 3.34 x 10(-7) and 4.92 x 10(-7), respectively, all lower than 10(-6). It indicated that there was no significant non-carcinogens and carcinogens hazard to workers inside the factory, but they might be exposed to more health risks if their work experience increase. Finally, recommendations for improving the environmental quality and personnel security in the factory were proposed based on the research results.

LTPP pavement maintenance materials : SHRP joint reseal experiment, final report.

DOT National Transportation Integrated Search

1999-09-01

The Strategic Highway Research Program (SHRP) H-106 maintenance experiment and the Federal Highway : Administration (FHWA) Long-Term Monitoring (LTM) of Pavement Maintenance Materials Test Sites project studied : the resealing of joints in concrete p...

Development and Confirmatory Factory Analysis of the Achievement Task Value Scale for University Students

ERIC Educational Resources Information Center

Lou, Yu-Chiung; Lin, Hsiao-Fang; Lin, Chin-Wen

2013-01-01

The aims of the study were (a) to develop a scale to measure university students' task value and (b) to use confirmatory factor analytic techniques to investigate the construct validity of the scale. The questionnaire items were developed based on theoretical considerations and the final version contained 38 items divided into 4 subscales.…

76 FR 80337 - Uncovered Innerspring Units From the People's Republic of China: Rescission of Antidumping Duty...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-23

... preliminarily found that Foshan Nanhai Jiujiang Quan Li Spring Hardware Factory's (``Quan Li'') sale was non-bona fide, and announced our preliminary intent to rescind Quan Li's NSR. For the final results of this review, we continue to find Quan Li's sale to be non-bona fide. Therefore, because there were no other...

Systematic Variations of Instructional Variables on Learner Performance: Aircraft Instrument Comprehension Task. Final Report, June 1973-July 1974.

ERIC Educational Resources Information Center

Tenpas, Barbara G.; And Others

Incentive, practice, instruction, and feedback were manipulated in a series of four 2 x 2 factorial studies, with Air Force Reserve Officer Training Corps cadets and graduate students in education, to determine the individual and combined effects of these variables on learner performance (both speed and accuracy) of an aircraft comprehension task.…

The ubiquitin-proteasome system is required for African swine fever replication.

PubMed

Barrado-Gil, Lucía; Galindo, Inmaculada; Martínez-Alonso, Diego; Viedma, Sergio; Alonso, Covadonga

2017-01-01

Several viruses manipulate the ubiquitin-proteasome system (UPS) to initiate a productive infection. Determined viral proteins are able to change the host's ubiquitin machinery and some viruses even encode their own ubiquitinating or deubiquitinating enzymes. African swine fever virus (ASFV) encodes a gene homologous to the E2 ubiquitin conjugating (UBC) enzyme. The viral ubiquitin-conjugating enzyme (UBCv1) is expressed throughout ASFV infection and accumulates at late times post infection. UBCv is also present in the viral particle suggesting that the ubiquitin-proteasome pathway could play an important role at early ASFV infection. We determined that inhibition of the final stage of the ubiquitin-proteasome pathway blocked a post-internalization step in ASFV replication in Vero cells. Under proteasome inhibition, ASF viral genome replication, late gene expression and viral production were severely reduced. Also, ASFV enhanced proteasome activity at late times and the accumulation of polyubiquitinated proteins surrounding viral factories. Core-associated and/or viral proteins involved in DNA replication may be targets for the ubiquitin-proteasome pathway that could possibly assist virus uncoating at final core breakdown and viral DNA release. At later steps, polyubiquitinated proteins at viral factories could exert regulatory roles in cell signaling.

Tamarind seed gum-hydrolyzed polymethacrylamide-g-gellan beads for extended release of diclofenac sodium using 32 full factorial design.

PubMed

Nandi, Gouranga; Nandi, Amit Kumar; Khan, Najim Sarif; Pal, Souvik; Dey, Sibasish

2018-07-15

Development of tamarind seed gum (TSG)-hydrolyzed polymethacrylamide-g-gellan (h-Pmaa-g-GG) composite beads for extended release of diclofenac sodium using 3 2 full factorial design is the main purpose of this study. The ratio of h-Pmaa-g-GG and TSG and concentration of cross-linker CaCl 2 were taken as independent factors with three different levels of each. Effects of polymer ratio and CaCl 2 on drug entrapment efficiency (DEE), drug release, bead size and swelling were investigated. Responses such as DEE and different drug release parameters were statistically analyzed by 3 2 full factorial design using Design-Expert software and finally the formulation factors were optimized to obtain USP-reference release profile. Drug release rate was found to decrease with decrease in the ratio of h-Pmaa-g-GG:TSG and increase in the concentration of Ca 2+ ions in cross-linking medium. The optimized formulation showed DEE of 93.25% and an extended drug release profile over a period of 10h with f 2 =80.13. Kinetic modeling unveiled case-I-Fickian diffusion based drug release mechanism. Copyright © 2018 Elsevier B.V. All rights reserved.

DKIST enclosure modeling and verification during factory assembly and testing

NASA Astrophysics Data System (ADS)

Larrakoetxea, Ibon; McBride, William; Marshall, Heather K.; Murga, Gaizka

2014-08-01

The Daniel K. Inouye Solar Telescope (DKIST, formerly the Advanced Technology Solar Telescope, ATST) is unique as, apart from protecting the telescope and its instrumentation from the weather, it holds the entrance aperture stop and is required to position it with millimeter-level accuracy. The compliance of the Enclosure design with the requirements, as of Final Design Review in January 2012, was supported by mathematical models and other analyses which included structural and mechanical analyses (FEA), control models, ventilation analysis (CFD), thermal models, reliability analysis, etc. During the Enclosure Factory Assembly and Testing the compliance with the requirements has been verified using the real hardware and the models created during the design phase have been revisited. The tests performed during shutter mechanism subsystem (crawler test stand) functional and endurance testing (completed summer 2013) and two comprehensive system-level factory acceptance testing campaigns (FAT#1 in December 2013 and FAT#2 in March 2014) included functional and performance tests on all mechanisms, off-normal mode tests, mechanism wobble tests, creation of the Enclosure pointing map, control system tests, and vibration tests. The comparison of the assumptions used during the design phase with the properties measured during the test campaign provides an interesting reference for future projects.

77 FR 31577 - Non-Malleable Cast Iron Pipe Fittings From the People's Republic of China: Final Results of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-29

... as ``flared joint.'' The flared joint, once made fast, permits brake fluid to flow through channels...), or push on ends (PO), or flanged ends and produced to the American Water Works Association (AWWA... flared joint, once made fast, permits brake fluid to flow through channels that never exceed 3.8...

75 FR 79394 - United States v. L.B. Foster Company and Portec Rail Products, Inc.; Proposed Final Judgment and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-20

... Foster and Portec will create a virtual monopoly in the U.S. market for bonded joints. (2) Poly Joints 29... Class 1 railroads, insist that new bonded joints undergo laboratory testing plus several years of in... would have a virtual monopoly in that market. Using a measure called the Herfindahl/Hirschman Index...

Evaluation of joint sealant materials : final report.

DOT National Transportation Integrated Search

1977-05-01

In May, 1968, the Department's Research and Development Section initiated a project to evaluate joint sealants being marketed for use on roads and bridges. In the study, representatives of 31 companies installed 40 products primarily on one road and ...

[Questionnaire to assess advertising campaigns impact about HIV/AIDS prevention].

PubMed

Bretón-López, Juana; Buela-Casal, Gualberto

2006-08-01

Present work is concerned with a questionnaire aimed to the impact evaluation of a selection of Spanish advertising campaigns about HIV/AIDS prevention. The work objective is to determine reliability and factorial structure of the instrument. It is described the designed questionnaire and its three scales (affective impact scale, cognitive impact scale and behavioural intention impact scale). The sample was composed by 405 high school teenagers to who were projected the advertising campaigns. So, teenagers filled the designed questionnaire. From a theoretical and psychometric point of view, data show the instrument is appropriate about internal consistency and factorial structure. The final goal of the questionnaire is to become useful tool to assess the persuasive effectiveness of the advertising campaigns within the HIV/AIDS network, as an intervention of primary prevention to reduce the expansion of epidemic.

Expansion of chemical space for collaborative lead generation and drug discovery: the European Lead Factory Perspective.

PubMed

Karawajczyk, Anna; Giordanetto, Fabrizio; Benningshof, Jorg; Hamza, Daniel; Kalliokoski, Tuomo; Pouwer, Kees; Morgentin, Remy; Nelson, Adam; Müller, Gerhard; Piechot, Alexander; Tzalis, Dimitrios

2015-11-01

High-throughput screening (HTS) represents a major cornerstone of drug discovery. The availability of an innovative, relevant and high-quality compound collection to be screened often dictates the final fate of a drug discovery campaign. Given that the chemical space to be sampled in research programs is practically infinite and sparsely populated, significant efforts and resources need to be invested in the generation and maintenance of a competitive compound collection. The European Lead Factory (ELF) project is addressing this challenge by leveraging the diverse experience and know-how of academic groups and small and medium enterprises (SMEs) engaged in synthetic and/or medicinal chemistry. Here, we describe the novelty, diversity, structural complexity, physicochemical characteristics and overall attractiveness of this first batch of ELF compounds for HTS purposes. Copyright © 2015 Elsevier Ltd. All rights reserved.

The Democritos Movement Screening Tool for Preschool Children (DEMOST-PRE©): development and factorial validity.

PubMed

Kambas, Antonis; Venetsanou, Fotini

2014-07-01

The aim of this study was (a) to develop an assessment tool (the Democritos Movement Screening Tool for Preschool Children - DEMOST-PRE), designed to provide preschool educators, clinicians and researchers with information about assessment and screening of the motor proficiency of children aged 4-6 years, as well as the development and control of movement programmes and (b) to assess its factorial validity. First, tool's content and face validity were established and its final structure was determined. Then, the DEMOST-PRE was administered to 435 children (197 girls) aged 48-71 months (M=60.48 months, SD=6.98). The factor analysis conducted revealed two distinct components. Present evidence combined with the DEMOST-PRE administrative traits make it promising for preschool aged children's assessment. Copyright © 2014 Elsevier Ltd. All rights reserved.

Rescue workers and trauma: Assessing interaction among risk factors after a firework factory explosion.

PubMed

Romano, Eugenia; Elklit, Ask

This study investigates which factors had the biggest impact on developing distress in rescue workers who were involved in a firework factory explosion. Four hundred sixty-five rescuers were assessed using items investigating demographic factors, organizational variables, social support, personality variables, and distress symptoms. Correlation and regression analyses were performed. Our final model provided 70 percent of the predictive model for post-traumatic stress disorder (PTSD) severity. Waiting time, lack of rest, problems at work, and perceived level of danger seemed to have the highest impact on protective factors. In addition to perceived life danger and personality, small organizational factors seem to play an important role in the prediction of PTSD. The importance of such factors needs further investigation in future research, contributing to a better organization in the field of disaster management.

NASA Research Announcement Phase 2 Final Report for the Development of a Power Assisted Space Suit Glove

NASA Technical Reports Server (NTRS)

Lingo, Robert; Cadogan, Dave; Sanner, Rob; Sorenson, Beth

1997-01-01

The main goal of this program was to develop an unobtrusive power-assisted EVA glove metacarpalphalangeal (MCP) joint that could provide the crew member with as close to nude body performance as possible, and to demonstrate the technology feasibility of power assisted space suit components in general. The MCP joint was selected due to its being representative of other space suit joints, such as the shoulder, hip and carpometacarpal joint, that would also greatly benefit from this technology. In order to meet this objective, a development team of highly skilled and experienced personnel was assembled. The team consisted of two main entities. The first was comprised of ILC's experienced EVA space suit glove designers, who had the responsibility of designing and fabricating a low torque MCP joint which would be compatible with power assisted technology. The second part of the team consisted of space robotics experts from the University of Maryland's Space Systems Laboratory. This team took on the responsibility of designing and building the robotics aspects of the power-assist system. Both parties addressed final system integration responsibilities.

Joint Operating Environment 2035: The Joint Force in a Contested and Disordered World

DTIC Science & Technology

2016-07-14

environment. Next, Section 2 explores how the intersection and interaction of these changes might impact the character of war in the future. Finally, Section...ideas about how changes to conflict and war might impact the capabilities and operational approaches required by the future Joint Force. These...1 Colin Gray, Another Bloody Century, (2005), p. 43. 2 challenges that will impact the

Spatio-thermal depth correction of RGB-D sensors based on Gaussian processes in real-time

NASA Astrophysics Data System (ADS)

Heindl, Christoph; Pönitz, Thomas; Stübl, Gernot; Pichler, Andreas; Scharinger, Josef

2018-04-01

Commodity RGB-D sensors capture color images along with dense pixel-wise depth information in real-time. Typical RGB-D sensors are provided with a factory calibration and exhibit erratic depth readings due to coarse calibration values, ageing and thermal influence effects. This limits their applicability in computer vision and robotics. We propose a novel method to accurately calibrate depth considering spatial and thermal influences jointly. Our work is based on Gaussian Process Regression in a four dimensional Cartesian and thermal domain. We propose to leverage modern GPUs for dense depth map correction in real-time. For reproducibility we make our dataset and source code publicly available.

Efficacy of Dorsoradial Capsulodesis for Trapeziometacarpal Joint Instability: A Cadaver Study.

PubMed

Chenoweth, Brian A; O'Mahony, Gavin D; Fitzgerald, Casey; Stoner, Julie A; O'Donoghue, Daniel L; Rayan, Ghazi M

2017-01-01

To test the biomechanical properties of the dorsoradial capsulodesis procedure. Six cadaveric hands were used. After exposing the trapeziometacarpal (TMC) joint, we placed Kirschner wires in the distal radius and thumb metacarpal. The rotation shear test was then performed to test the joint axial laxity, and angular measurements using Kirschner wires as reference points were documented. The dorsoradial (DR) ligament and capsule were released, followed by the intermetacarpal (IM) ligament; angular measurements were obtained. Finally, the DR capsulodesis procedure was performed, and final measurements were obtained. Comparisons were made among the various stages of ligament integrity to determine the amount of stability provided by DR capsulodesis. All cadavers demonstrated axial laxity with transection of the DR ligament; an increase in stability was obtained after DR capsulodesis. Transection of the capsule and IM ligament caused increased laxity relative to the native joint (median, 24° and 35°, respectively, on rotational testing). After we performed DR capsulodesis, rotational stability improved by a median of 41° compared with DR ligament transection, 49° compared with DR and IM ligament transection, and 18° relative to the native joint. Dorsoradial capsulodesis restores rotational stability for TMC joint after division of the DR and IM ligaments. The stability achieved was statistically significant compared with both an intact native TMC joint and induced laxity of the TMC joint. The DR capsulodesis procedure may improve rotational stability to the TMC joint. Copyright © 2017 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.

Allocating Sample Sizes to Reduce Budget for Fixed-Effect 2×2 Heterogeneous Analysis of Variance

ERIC Educational Resources Information Center

Luh, Wei-Ming; Guo, Jiin-Huarng

2016-01-01

This article discusses the sample size requirements for the interaction, row, and column effects, respectively, by forming a linear contrast for a 2×2 factorial design for fixed-effects heterogeneous analysis of variance. The proposed method uses the Welch t test and its corresponding degrees of freedom to calculate the final sample size in a…

Accounting for dropout in xenografted tumour efficacy studies: integrated endpoint analysis, reduced bias and better use of animals.

PubMed

Martin, Emma C; Aarons, Leon; Yates, James W T

2016-07-01

Xenograft studies are commonly used to assess the efficacy of new compounds and characterise their dose-response relationship. Analysis often involves comparing the final tumour sizes across dose groups. This can cause bias, as often in xenograft studies a tumour burden limit (TBL) is imposed for ethical reasons, leading to the animals with the largest tumours being excluded from the final analysis. This means the average tumour size, particularly in the control group, is underestimated, leading to an underestimate of the treatment effect. Four methods to account for dropout due to the TBL are proposed, which use all the available data instead of only final observations: modelling, pattern mixture models, treating dropouts as censored using the M3 method and joint modelling of tumour growth and dropout. The methods were applied to both a simulated data set and a real example. All four proposed methods led to an improvement in the estimate of treatment effect in the simulated data. The joint modelling method performed most strongly, with the censoring method also providing a good estimate of the treatment effect, but with higher uncertainty. In the real data example, the dose-response estimated using the censoring and joint modelling methods was higher than the very flat curve estimated from average final measurements. Accounting for dropout using the proposed censoring or joint modelling methods allows the treatment effect to be recovered in studies where it may have been obscured due to dropout caused by the TBL.

Enhanced treatment selection for reflective joint cracking in composite pavements : final report.

DOT National Transportation Integrated Search

2015-09-01

This research developed a decisionmaking process that can be used by INDOT to enhance identification of the condition of the : underlying concrete joints or cracks by looking at the surface distresses of the asphalt overlay in composite pavements....

Utilization of Facet Joint and Sacroiliac Joint Interventions in Medicare Population from 2000 to 2014: Explosive Growth Continues!

PubMed

Manchikanti, Laxmaiah; Hirsch, Joshua A; Pampati, Vidyasagar; Boswell, Mark V

2016-10-01

Increasing utilization of interventional techniques in managing chronic spinal pain, specifically facet joint interventions and sacroiliac joint injections, is a major concern of healthcare policy makers. We analyzed the patterns of utilization of facet and sacroiliac joint interventions in managing chronic spinal pain. The results showed significant increase of facet joint interventions and sacroiliac joint injections from 2000 to 2014 in Medicare FFS service beneficiaries. Overall, the Medicare population increased 35 %, whereas facet joint and sacroiliac joint interventions increased 313.3 % per 100,000 Medicare population with an annual increase of 10.7 %. While the increases were uniform from 2000 to 2014, there were some decreases noted for facet joint interventions in 2007, 2010, and 2013, whereas for sacroiliac joint injections, the decreases were noted in 2007 and 2013. The increases were for cervical and thoracic facet neurolysis at 911.5 % compared to lumbosacral facet neurolysis of 567.8 %, 362.9 % of cervical and thoracic facet joint blocks, 316.9 % of sacroiliac joints injections, and finally 227.3 % of lumbosacral facet joint blocks.

Particulate matters collected from ceramic factories in Lampang Province affecting rat lungs.

PubMed

Fongmoon, Duriya; Pongnikorn, Surathat; Chaisena, Aphiruk; Iamsaard, Sitthichai

2014-01-01

Lung cancer ranks as the fifth largest of all cancer cases in Thailand. However, it is the first leading cancer in the northern part of Thailand (data from 2003-2007). There are several predisposing causes that lead to lung cancer and one important inducement is particulate matters (PMs). Lampang Province in Thailand is famous for the ceramic industry, where there are over 200 ceramic industrial factories. PMs are produced during the ceramic manufacturing process and spread throughout all of the working areas. It is very possible that workers could directly inhale PM-contaminated air during working hours. This study focuses on the toxic effects of PMs collected from ceramic factories on genes and lungs of rats. PMs collected from six ceramic factories in Lampang Province were extracted using dimethyl sulfoxide (DMSO). The inductively coupled plasma mass spectrometry (ICP-MS) and inductively coupled plasma optical emission spectrometry (ICP-OES) were used to analyze the chemical elements at lower and higher concentrations, respectively. Then, the toxicity of PMs on the genes was examined by the Ames test, and subsequently, the effect of PMs on DNA was examined by quantifying the amount of 8-hydroxy-2'-deoxyguanosine (8-OHdG). Finally, the toxicity of the PMs on rat's lungs was examined by histology. As chemical elements of lower concentrations, cadmium, chromium, nickel, copper, and lead were detected by ICP-MS. As chemical elements of higher concentrations, manganese, magnesium, zinc, iron, potassium, calcium, and sodium were detected by ICP-OES. No mutagenicity in Salmonella typhimurium was found in the PM extracts from all six factories by utilizing the Ames test. In the histological study, the reduction in spaces of alveolar ducts and sacs, and terminal bronchioles, the thickening of interstitial connective tissues were noted by PM extracts in high amounts (100 and 350 µg). Female rats were more sensitive to PM extracts than males in terms of their pulmonary damages. PMs were not mutagenic to S. typhimurium but can damage the lung tissue of rats.

TEAM (Technologies Enabling Agile Manufacturing) shop floor control requirements guide: Version 1.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-03-28

TEAM will create a shop floor control system (SFC) to link the pre-production planning to shop floor execution. SFC must meet the requirements of a multi-facility corporation, where control must be maintained between co-located facilities down to individual workstations within each facility. SFC must also meet the requirements of a small corporation, where there may only be one small facility. A hierarchical architecture is required to meet these diverse needs. The hierarchy contains the following levels: Enterprise, Factory, Cell, Station, and Equipment. SFC is focused on the top three levels. Each level of the hierarchy is divided into three basicmore » functions: Scheduler, Dispatcher, and Monitor. The requirements of each function depend on the hierarchical level in which it is to be used. For example, the scheduler at the Enterprise level must allocate production to individual factories and assign due-dates; the scheduler at the Cell level must provide detailed start and stop times of individual operations. Finally the system shall have the following features: distributed and open-architecture. Open architecture software is required in order that the appropriate technology be used at each level of the SFC hierarchy, and even at different instances within the same hierarchical level (for example, Factory A uses discrete-event simulation scheduling software, and Factory B uses an optimization-based scheduler). A distributed implementation is required to reduce the computational burden of the overall system, and allow for localized control. A distributed, open-architecture implementation will also require standards for communication between hierarchical levels.« less

JOMAR: Joint Operations with Mobile Autonomous Robots

DTIC Science & Technology

2015-12-21

AFRL-AFOSR-JP-TR-2015-0009 JOMAR: Joint Operations with Mobile Autonomous Robots Edwin Olson UNIVERSITY OF MICHIGAN Final Report 12/21/2015...SUBTITLE JOMAR: Joint Operations with Mobile Autonomous Robots 5a. CONTRACT NUMBER FA23861114024 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6...14. ABSTRACT Under this grant, we formulated and implemented a variety of novel algorithms that address core problems in multi- robot systems. These

Analysis of light incident location and detector position in early diagnosis of knee osteoarthritis by Monte Carlo simulation

NASA Astrophysics Data System (ADS)

Chen, Yanping; Chen, Yisha; Yan, Huangping; Wang, Xiaoling

2017-01-01

Early detection of knee osteoarthritis (KOA) is meaningful to delay or prevent the onset of osteoarthritis. In consideration of structural complexity of knee joint, position of light incidence and detector appears to be extremely important in optical inspection. In this paper, the propagation of 780-nm near infrared photons in three-dimensional knee joint model is simulated by Monte Carlo (MC) method. Six light incident locations are chosen in total to analyze the influence of incident and detecting location on the number of detected signal photons and signal to noise ratio (SNR). Firstly, a three-dimensional photon propagation model of knee joint is reconstructed based on CT images. Then, MC simulation is performed to study the propagation of photons in three-dimensional knee joint model. Photons which finally migrate out of knee joint surface are numerically analyzed. By analyzing the number of signal photons and SNR from the six given incident locations, the optimal incident and detecting location is defined. Finally, a series of phantom experiments are conducted to verify the simulation results. According to the simulation and phantom experiments results, the best incident location is near the right side of meniscus at the rear end of left knee joint and the detector is supposed to be set near patella, correspondingly.

Light-duty vehicle greenhouse gas emission standards and corporate average fuel economy standards : final rule

DOT National Transportation Integrated Search

2010-05-07

Final Rule to establish a National Program consisting of new standards for light-duty vehicles that will reduce greenhouse gas emissions and improve fuel economy. This joint : Final Rule is consistent with the National Fuel Efficiency Policy announce...

Hydrothermal corrosion of silicon carbide joints without radiation

DOE PAGES

Koyanagi, Takaaki; Katoh, Yutai; Terrani, Kurt A.; ...

2016-09-28

In this paper, hydrothermal corrosion of four types of the silicon carbide (SiC) to SiC plate joints were investigated under pressurized water reactor and boiling water reactor relevant chemical conditions without irradiation. The joints were formed by metal diffusion bonding using molybdenum or titanium interlayer, reaction sintering using Ti—Si—C system, and SiC nanopowder sintering. Most of the joints withstood the corrosion tests for five weeks. The recession of the SiC substrates was limited. Based on the recession of the bonding layers, it was concluded that all the joints except for the molybdenum diffusion bond are promising under the reducing environmentsmore » without radiation. Finally, the SiC nanopowder sintered joint was the most corrosion tolerant under the oxidizing environment among the four joints.« less

Low cracking concretes for the closure pours and overlays of the Dunlap Creek Bridge : final report.

DOT National Transportation Integrated Search

2017-10-01

Joints, wide cracks, and poor-quality concretes facilitate the intrusion of chlorides, causing corrosion in bridge decks and substructures. In this study, joints were replaced with closure pours (link slabs) consisting of low permeability fiber-reinf...

Controlling under-actuated robot arms using a high speed dynamics process

NASA Technical Reports Server (NTRS)

Jain, Abhinandan (Inventor); Rodriguez, Guillermo (Inventor)

1994-01-01

The invention controls an under-actuated manipulator by first obtaining predetermined active joint accelerations of the active joints and the passive joint friction forces of the passive joints, then computing articulated body qualities for each of the joints from the current positions of the links, and finally computing from the articulated body qualities and from the active joint accelerations and the passive joint forces, active joint forces of the active joints. Ultimately, the invention transmits servo commands to the active joint forces thus computed to the respective ones of the joint servos. The computation of the active joint forces is accomplished using a recursive dynamics algorithm. In this computation, an inward recursion is first carried out for each link, beginning with the outermost link in order to compute the residual link force of each link from the active joint acceleration if the corresponding joint is active, or from the known passive joint force if the corresponding joint is passive. Then, an outward recursion is carried out for each link in which the active joint force is computed from the residual link force if the corresponding joint is active or the passive joint acceleration is computed from the residual link force if the corresponding joint is passive.

Microbial Routes to (2R,3R)-2,3-Butanediol: Recent Advances and Future Prospects.

PubMed

Xie, Neng-Zhong; Chen, Xian-Rui; Wang, Qing-Yan; Chen, Dong; Du, Qi-Shi; Zhou, Guo-Ping; Huang, Ri-Bo

2017-01-01

(2R,3R)-2,3-Butanediol has many industrial applications, such as it is used as an antifreeze agent and low freezing point fuel. In addition, it is particularly important to provide chiral groups in drugs. In recent years, this valuable bio-based chemical has attracted increasing attention, and significant progress has been made in the development of microbial cell factories for (2R,3R)-2,3-butanediol production. This article reviews recent advances and challenges in microbial routes to (2R,3R)-2,3- butanediol production, and highlights the metabolic engineering and synthetic biological approaches used to improve titers, yields, productivities, and optical purities. Finally, a systematic and integrative strategy for developing high-performance microbial cell factories is proposed. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

[Validation of a scale measuring coping with extreme risks].

PubMed

López-Vázquez, Esperanza; Marván, María Luisa

2004-01-01

The objective of this study was to validate, in Mexico, the French coping scale "Echelle Toulousaine de Coping". In the fall of 2001, the scale questionnaire was applied to 209 subjects living in different areas of Mexico, exposed to five different types of extreme natural or industrial risks. The discriminatory capacity of the items, as well as the factorial structure and internal consistency of the scale, were analyzed using Mann-Whitney's U test, principal components factorial analysis, and Cronbach's alpha. The final scale was composed of 26 items forming two groups: active coping and passive coping. Internal consistency of the instrument was high, both in the total sample and in the subsample of natural and industrial risks. The coping scale is reliable and valid for the Mexican population. The English version of this paper is available at: http://www.insp.mx/salud/index.html.

The ideal neutrino beams

NASA Astrophysics Data System (ADS)

Lindroos, Mats

2009-06-01

The advance in neutrino oscillation physics is driven by the availability of well characterized and high flux neutrino beams. The three present options for the next generation neutrino oscillation facility are super beams, neutrino factories and beta-beams. A super-beam is a very high intensity classical neutrino beam generated by protons impinging on a target where the neutrinos are generated by the secondary particles decaying in a tunnel down streams of the target. In a neutrino factory the neutrinos are generated from muons decaying in a storage ring with long straight sections pointing towards the detectors. In a beta-beam the neutrinos are also originating from decay in a storage ring but the decaying particles are radioactive ions rather than muons. I will in this presentation review the three options and discuss the pros and cons of each. The present joint design effort for a future high intensity neutrino oscillation in Europe within a common EU supported design study, EURONU, will also be presented. The design study will explore the physics reach, the detectors, the feasibility, the safety issues and the cost for each of the options so that the the community can take a decision on what to build when the facilities presently under exploitation and construction have to be replaced.

Accelerator Physics Working Group Summary

NASA Astrophysics Data System (ADS)

Li, D.; Uesugi, T.; Wildnerc, E.

2010-03-01

The Accelerator Physics Working Group addressed the worldwide R&D activities performed in support of future neutrino facilities. These studies cover R&D activities for Super Beam, Beta Beam and muon-based Neutrino Factory facilities. Beta Beam activities reported the important progress made, together with the research activity planned for the coming years. Discussion sessions were also organized jointly with other working groups in order to define common ground for the optimization of a future neutrino facility. Lessons learned from already operating neutrino facilities provide key information for the design of any future neutrino facility, and were also discussed in this meeting. Radiation damage, remote handling for equipment maintenance and exchange, and primary proton beam stability and monitoring were among the important subjects presented and discussed. Status reports for each of the facility subsystems were presented: proton drivers, targets, capture systems, and muon cooling and acceleration systems. The preferred scenario for each type of possible future facility was presented, together with the challenges and remaining issues. The baseline specification for the muon-based Neutrino Factory was reviewed and updated where required. This report will emphasize new results and ideas and discuss possible changes in the baseline scenarios of the facilities. A list of possible future steps is proposed that should be followed up at NuFact10.

Reliability analysis of different structure parameters of PCBA under drop impact

NASA Astrophysics Data System (ADS)

Liu, P. S.; Fan, G. M.; Liu, Y. H.

2018-03-01

The establishing process of PCBA is modelled by finite element analysis software ABAQUS. Firstly, introduce the Input-G method and the fatigue life under drop impact are introduced and the mechanism of the solder joint failure in the process of drop is analysed. The main reason of solder joint failure is that the PCB component is suffering repeated tension and compression stress during the drop impact. Finally, the equivalent stress and peel stress of different solder joint and plate-level components under different impact acceleration are also analysed. The results show that the reliability of tin-silver copper joint is better than that of tin- lead solder joint, and the fatigue life of solder joint expectancy decrease as the impact pulse amplitude increases.

77 FR 64102 - Frozen Warmwater Shrimp From the Socialist Republic of Vietnam: Amended Final Results and Partial...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-18

... of the request for review of BIM Seafood Joint Stock Company (``BIM Seafood''), the Department preliminarily rescinded this review with respect to BIM Seafood. Subsequent to the Final Results, the Department discovered that we had inadvertently failed to include the final rescission for BIM Seafood in the Final...

Development of Stable, Low Resistance Solder Joints for a Space-Flight HTS Lead Assemblies

NASA Technical Reports Server (NTRS)

Canavan, Edgar R.; Chiao, Meng; Panashchenko, Lyudmyla; Sampson, Michael

2017-01-01

The solder joints in spaceflight high temperature superconductor (HTS) lead assemblies for certain astrophysics missions have strict constraints on size and power dissipation. In addition, the joints must tolerate years of storage at room temperature, many thermal cycles, and several vibration tests between their manufacture and their final operation on orbit. As reported previously, solder joints between REBCO coated conductors and normal metal traces for the Astro-H mission showed low temperature joint resistance that grew approximately as log time over the course of months. Although the assemblies worked without issue in orbit, for the upcoming X-ray Astrophysics Recovery Mission we are attempting to improve our solder process to give lower, more stable, and more consistent joint resistance. We produce numerous sample joints and measure time- and thermal cycle-dependent resistance, and characterize the joints using x-ray and other analysis tools. For a subset of the joints, we use SEMEDS to try to understand the physical and chemical processes that effect joint behavior.

School Refusal Assessment Scale-Revised: Factorial Invariance and Latent Means Differences across Gender and Age in Spanish Children

PubMed Central

Gonzálvez, Carolina; Inglés, Cándido J.; Kearney, Christopher A.; Vicent, María; Sanmartín, Ricardo; García-Fernández, José M.

2016-01-01

The aim of this study was to analyze the factorial invariance and latent means differences of the Spanish version of the School Refusal Assessment Scale-Revised for Children (SRAS-R-C) in a sample of 1,078 students (50.8% boys) aged 8–11 years (M = 9.63, SD = 1.12). The results revealed that the proposed model in this study, with a structure of 18 items divided into four factors (Negative Affective, Social Aversion and/or Evaluation, To Pursue Attention and Tangible Reinforcements), was the best-fit model with a tetra-factorial structure, remaining invariant across gender and age. Analysis of latent means differences indicated that boys and 11-year-old students scored highest on the Tangible Reinforcements subscale compared with their 8- and 9-year-old peers. On the contrary, for the subscales of Social Aversion and/or Evaluation and to Pursue Attention, the differences were significant and higher in younger age groups compared to 11-year-olds. Appropriate indexes of reliability were obtained for SRAS-R-C subscales (0.70, 0.79, 0.87, and 0.72). Finally, the founded correlation coefficients of scores of the SRAS-R-C revealed a predictable pattern between school refusal and positive/negative affect and optimism/pessimism. PMID:28082938

TROPHI: development of a tool to measure complex, multi-factorial patient handling interventions.

PubMed

Fray, Mike; Hignett, Sue

2013-01-01

Patient handling interventions are complex and multi-factorial. It has been difficult to make comparisons across different strategies due to the lack of a comprehensive outcome measurement method. The Tool for Risk Outstanding in Patient Handling Interventions (TROPHI) was developed to address this gap by measuring outcomes and comparing performance across interventions. Focus groups were held with expert patient handling practitioners (n = 36) in four European countries (Finland, Italy, Portugal and the UK) to identify preferred outcomes to be measured for interventions. A systematic literature review identified 598 outcome measures; these were critically appraised and the most appropriate measurement tool was selected for each outcome. TROPHI was evaluated in the four EU countries (eight sites) and by an expert panel (n = 16) from the European Panel of Patient Handling Ergonomics for usability and practical application. This final stage added external validity to the research by exploring transferability potential and presenting the data and analysis to allow respondent (participant) validation. Patient handling interventions are complex and multi-factorial and it has been difficult to make comparisons due to the lack of a comprehensive outcome measurement method. The Tool for Risk Outstanding in Patient Handling Interventions (TROPHI) was developed to address this gap by measuring outcomes to compare performance across interventions.

Association of soil cadmium contamination with ceramic industry: a case study in a Chinese town.

PubMed

Liao, Q Lin; Liu, Cong; Wu, H Yun; Jin, Yang; Hua, Ming; Zhu, B Wan; Chen, Kai; Huang, Lei

2015-05-01

Soil cadmium (Cd) contamination is attributable to many sources, among which the ceramic industry is probably an important contributor whose relationship will be explored in this study. Upon studying a town in southeastern China that is quite famous for its ceramics, we observed that the soil Cd distribution agreed with the local ceramic industry's distribution in space and time from 2004 to 2014. Ceramic and pigment samples from a typical factory were selected in a case study, and a sediment core from a nearby river was collected. First, an application of the geo-accumulation index suggested that the sediment was very strongly polluted by Cd (mean 1874 mg/kg). Second, sediment dating indicated that the Cd concentration surge and the establishment of the factory were proximate in time (2002-2004). Third, principal component analysis showed high loading of Cd (0.947) solely, suggesting that the factory was most likely responsible for the Cd pollution found in the sediments of a nearby river. Finally, we infer that the soil cadmium pollution in the whole area may be related to the region's prosperous ceramic industry. Local government should reinforce controls of the ceramic industry and implement effective countermeasures. Copyright © 2015 Elsevier B.V. All rights reserved.

Evaluation of high-performance fiber-reinforced concrete for bridge deck connections, closure pours, and joints : final report.

DOT National Transportation Integrated Search

2017-01-01

Connections, closure pours, and joints in bridges are often sources of distress because of cracks and openings. Wide separation facilitates the penetration of harmful solutions that can lead to costly repairs. Cracks are caused by volumetric changes ...

76 FR 42573 - Radio Broadcasting Services; Oklahoma and Texas

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-19

...: Final rule; application for review. SUMMARY: This document denies the Application for Review filed by... Texas Licenses, L.P. (``Joint Petitioners'') of the dismissal of a second alternative proposal to their...). In response to the NPRM, the Joint Petitioners filed a mutually exclusive Counterproposal involving...

Experimental use of sawed and sealed joints to minimize thermal cracking : final report - August 2004.

DOT National Transportation Integrated Search

2004-08-01

Saw and Seal is the process of introducing uniformly spaced saw joints to a bituminous overlay in an : attempt to eliminate or retard the formation of thermal and /or reflective cracking. : Saw and Seal technology has been experimented with for...

The transport of wear particles in the prosthetic hip joint: a computational fluid dynamics investigation.

PubMed

Hölzer, Andreas; Schröder, Christian; Woiczinski, Matthias; Sadoghi, Patrick; Müller, Peter E; Jansson, Volkmar

2012-02-02

The joint fluid mechanics and transport of wear particles in the prosthetic hip joint were analyzed for subluxation and flexion motion using computational fluid dynamics (CFD). The entire joint space including a moving capsule boundary was considered. It was found that particles suspended in the joint space are drawn into the joint gap between prosthesis cup and head during subluxation, which was also documented by Lundberg et al. (2007; Journal of Biomechanics 40, 1676-1685), however, wear particles remain in the joint gap. Wear particles leave the joint gap during flexion and can finally migrate to the proximal boundaries including the acetabular bone, where the particle deposition can cause osteolysis according to the established literature. Thus, the present study supports the theory of polyethylene wear particle induced osteolysis of the acetabular bone as a major factor in the loosening of hip prosthesis cups. Copyright © 2011 Elsevier Ltd. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dwyer, Morgan Maeve

This report summarizes the results of doctoral research that explored the cost impact of acquiring complex government systems jointly. The report begins by reviewing recent evidence that suggests that joint programs experience greater cost growth than non-joint programs. It continues by proposing an alternative approach for studying cost growth on government acquisition programs and demonstrates the utility of this approach by applying it to study the cost of jointness on three past programs that developed environmental monitoring systems for low-Earth orbit. Ultimately, the report concludes that joint programs' costs grow when the collaborating government agencies take action to retain ormore » regain their autonomy. The report provides detailed qualitative and quantitative data in support of this conclusion and generalizes its findings to other joint programs that were not explicitly studied here. Finally, it concludes by presenting a quantitative model that assesses the cost impacts of jointness and by demonstrating how government agencies can more effectively architect joint programs in the future.« less

Final Environmental Assessment: For Joint Base Anacostia-Bolling Master Plan District of Columbia

DTIC Science & Technology

2010-09-30

the impacts of vehicle travel and facilitate alternative modes of transportation that would reduce air pollutants . Noise: There would be...ltlb•nKM nr~t~~G.,~ StEiiubetlls Fort McNair East Potomac Pari < Poplar Point "" Joint Base Anacostia-Bolling Master Plan Environmental...Industrial $uppon Eost Potomac Pari < Poplar Point Joint Base Anacostia-Bolling Master Plan Environmental Assessment pg. 16 Several general

Report on the Audit of the Joint Civilian Orientation Conference Fund

DTIC Science & Technology

1991-01-31

This is our final report on the audit of the Joint Civilian Orientation Conference (JCOC) Fund (the Fund). We performed the audit from June to July...1990. The Director, Budget and Finance, Washington Headquarters Services, requested the audit because a new Treasurer had been appointed. The overall...Instruction No. 48, Joint Civilian Orientation Conference Fund, May 31, 1983, and with DoD policy and guidelines. In addition, the audit evaluated

Increased delivery stride length places greater loads on the ankle joint in elite male cricket fast bowlers.

PubMed

Spratford, Wayne; Hicks, Amy

2014-01-01

The purpose of this study was to investigate the effect stride length has on ankle biomechanics of the leading leg with reference to the potential risk of injury in cricket fast bowlers. Ankle joint kinematic and kinetic data were collected from 51 male fast bowlers during the stance phase of the final delivery stride. The bowling cohort comprised national under-19, first class and international-level athletes. Bowlers were placed into either Short, Average or Long groups based on final stride length, allowing statistical differences to be measured. A multivariate analysis of variance with a Bonferroni post-hoc correction (α = 0.05) revealed significant differences between peak plantarflexion angles (Short-Long P = 0.005, Average and Long P = 0.04) and negative joint work (Average-Long P = 0.026). This study highlighted that during fast bowling the ankle joint of the leading leg experiences high forces under wide ranges of movement. As stride length increases, greater amounts of negative work and plantarflexion are experienced. These increases place greater loads on the ankle joint and move the foot into positions that make it more susceptible to injuries such as posterior impingement syndrome.

Final Report: Superconducting Joints Between (RE)Ba 2Cu 3O 7-x Coated Conductors via Electric Field Assisted Processing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schwartz, Justin

Here we report the results from a project aimed at developing a fully superconducting joint between two REBCO coated conductors using electric field processing (EFP). Due to a reduction in the budget and time period of this contract, we reduced the project scope and focused first on the key scientific issues for forming a strong bond between conductors, and subsequently focused on improving through-the-joint transport. A modified timeline and task list is shown in Table 1, summarizing accomplishments to date. In the first period, we accomplished initial surface characterization as well as rounds of EFP experiments to begin to understandmore » processing parameters which produce well-bonded tapes. In the second phase, we explored the effects of two fundamental EFP parameters, voltage and pressure, and the limitations they place on the process. In the third phase, we achieved superconducting joints and established base characteristics of both the bonding process and the types of tapes best suited to this process. Finally, we investigated some of the parameters related to kinetics which appeared inhibit joint quality and performance.« less

Research and Development of Zinc Air Fuel Cell To Achieve Commercialization Final Report CRADA No. TC-1544-98

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cooper, J. F.; Haley, H. D.

The specific goal of this project was to advance the development of the zinc air fuel cell (ZAFC) towards commercial readiness in different mobile applications, including motor bikes, passenger cars, vans, buses and off-road vehicles (golf carts, factory equipment), and different stationary applications including generator sets, uninterruptible power systems and electric utility loading leveling and distributive power.

Continuation of support for the Intercampus Institute for Research at Particle Accelerators. Final technical report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Caldwell, D.; Eisner, A.

1997-10-01

During the budget period beginning May 16, 1995, the UCSD group of the U.C. Intercampus Institute for Research at Particle Accelerators devoted approximately 75% of its effort to the PEP-II B Factory and the associated BABAR detector at SLAC, and 25% of its effort to the LSND collaboration at LAMPF. Michael Sullivan spent all of his time on PEP-II, while Alan Eisner split his time between BABAR and LSND. Sullivan remained a critical member of the group designing the PEP-II interaction region and the machine-detector interface; and, in fact, toward the end of the period he left IIRPA to becomemore » a SLAC employee, in order to ensure his continued participation in those efforts. That work has focused on developing an interaction region in which the accelerator can achieve the required high specific luminosity while, at the same time, maintaining low enough beam background to allow a detector to operate. Both requirements are essential to achieving the primary physics goal of not only detecting but doing detailed measurements of CP violation. Eisner`s work on the BABAR detector concentrated on the electromagnetic (CsI crystal) calorimeter. With the calorimeter geometry largely established, he turned his attention more fully to the areas of calorimeter data acquisition and calibration. The data acquisition focus, was on understaning the performance of the proposed system via calculations and simulations, a joint project with Yao-xin Wang of the UCSB IIRPA group.« less

75 FR 34049 - FM Table of Allotments (The Dalles, Tualatin, Eugene, Albany, Lebanon, Paisley, and Diamond Lake...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-16

... and Goldendale, WA) AGENCY: Federal Communications Commission ACTION: Final rule; dismissal of..., LLC, Bicoastal, and Extra Media, Inc. (the ``Joint Parties'') filed a Motion to Dismiss the Petition for Reconsideration. The Joint Parties' Motion to Dismiss the Petition for Reconsideration contained a...

Dynamic analysis of clamp band joint system subjected to axial vibration

NASA Astrophysics Data System (ADS)

Qin, Z. Y.; Yan, S. Z.; Chu, F. L.

2010-10-01

Clamp band joints are commonly used for connecting circular components together in industry. Some of the systems jointed by clamp band are subjected to dynamic load. However, very little research on the dynamic characteristics for this kind of joint can be found in the literature. In this paper, a dynamic model for clamp band joint system is developed. Contact and frictional slip between the components are accommodated in this model. Nonlinear finite element analysis is conducted to identify the model parameters. Then static experiments are carried out on a scaled model of the clamp band joint to validate the joint model. Finally, the model is adopted to study the dynamic characteristics of the clamp band joint system subjected to axial harmonic excitation and the effects of the wedge angle of the clamp band joint and the preload on the response. The model proposed in this paper can represent the nonlinearity of the clamp band joint and be used conveniently to investigate the effects of the structural and loading parameters on the dynamic characteristics of this type of joint system.

Factorials of real negative and imaginary numbers - A new perspective.

PubMed

Thukral, Ashwani K

2014-01-01

Presently, factorials of real negative numbers and imaginary numbers, except for zero and negative integers are interpolated using the Euler's gamma function. In the present paper, the concept of factorials has been generalised as applicable to real and imaginary numbers, and multifactorials. New functions based on Euler's factorial function have been proposed for the factorials of real negative and imaginary numbers. As per the present concept, the factorials of real negative numbers, are complex numbers. The factorials of real negative integers have their imaginary part equal to zero, thus are real numbers. Similarly, the factorials of imaginary numbers are complex numbers. The moduli of the complex factorials of real negative numbers, and imaginary numbers are equal to their respective real positive number factorials. Fractional factorials and multifactorials have been defined in a new perspective. The proposed concept has also been extended to Euler's gamma function for real negative numbers and imaginary numbers, and beta function.

Translations on North Korea No. 622

DTIC Science & Technology

1978-10-13

Pyongyang Power Station 5 July Electric Factory Hamhung Machine Tool Factory Kosan Plastic Pipe Factory Sog’wangea Plastic Pipe Factory 8...August Factory Double Chollima Hamhung Disabled Veterans’ Plastic Goods Factory Mangyongdae Machine Tool Factory Kangso Coal Mine Tongdaewon Garment...21 Jul 78 p 4) innovating in machine tool production (NC 21 Jul 78 p 2) in 40 days of the 蔴 days of combat" raised coal production 10 percent

Final Assembly and Factory Testing of the Jefferson Lab SHMS Spectrometer Quadrupole and Dipole Superconducting Magnets

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brindza, Paul; Lassiter, Steven; Sun, Eric

Jefferson Lab is constructing an 11 Gev/c electron spectrometer called the Super High Momentum Spectrometer (SHMS) as part of the 12 GeV JLAB upgrade for experimental Hall C. Three of the five superconducting(SC) SHMS magnets are under construction at SigmaPhi in Vannes France as a result of an international competition for design and fabrication. The three magnets Q2 and Q3 60 cm bore quadrupoles and the 60 cm warm bore dipole are complete or near complete and have many design features in common. All three magnets share a common superconductor, collaring system, cryostat design, cold to warm support, cryogenic interface,more » burnout resistant current leads, DC power supply, quench protection, instrumentation and controls. The three magnets are collared, installed in cryostats and welded up and in various stages of final testing. The Q2 quadrupole is due to ship from France to America in August arriving during this ASC conference and has passed all final hipot, leak and pressure tests. The dipole is in leak and pressure testing as of July 2016 while the Q3 quadrupole requires some outer vacuum vessel assembly. Delivery of the Q3 and Dipole magnets will follow the Q2 at about 1 month intervals. Lastly, factory testing have included hipot and electrical tests, magnetic tests at low field, mechanical alignments to center the coils, leak tests and ASME Code required pressure tests. Upon installation in Hall C at JLAB cold testing will commence.« less

Siting a municipal solid waste disposal facility, part II: the effects of external criteria on the final decision.

PubMed

Korucu, M Kemal; Karademir, Aykan

2014-02-01

The procedure of a multi-criteria decision analysis supported by the geographic information systems was applied to the site selection process of a planning municipal solid waste management practice based on twelve different scenarios. The scenarios included two different decision tree modes and two different weighting models for three different area requirements. The suitability rankings of the suitable sites obtained from the application of the decision procedure for the scenarios were assessed by a factorial experimental design concerning the effect of some external criteria on the final decision of the site selection process. The external criteria used in the factorial experimental design were defined as "Risk perception and approval of stakeholders" and "Visibility". The effects of the presence of these criteria in the decision trees were evaluated in detail. For a quantitative expression of the differentiations observed in the suitability rankings, the ranking data were subjected to ANOVA test after a normalization process. Then the results of these tests were evaluated by Tukey test to measure the effects of external criteria on the final decision. The results of Tukey tests indicated that the involvement of the external criteria into the decision trees produced statistically meaningful differentiations in the suitability rankings. Since the external criteria could cause considerable external costs during the operation of the disposal facilities, the presence of these criteria in the decision tree in addition to the other criteria related to environmental and legislative requisites could prevent subsequent external costs in the first place.

Final Assembly and Factory Testing of the Jefferson Lab SHMS Spectrometer Quadrupole and Dipole Superconducting Magnets

DOE PAGES

Brindza, Paul; Lassiter, Steven; Sun, Eric; ...

2017-06-01

Jefferson Lab is constructing an 11 Gev/c electron spectrometer called the Super High Momentum Spectrometer (SHMS) as part of the 12 GeV JLAB upgrade for experimental Hall C. Three of the five superconducting(SC) SHMS magnets are under construction at SigmaPhi in Vannes France as a result of an international competition for design and fabrication. The three magnets Q2 and Q3 60 cm bore quadrupoles and the 60 cm warm bore dipole are complete or near complete and have many design features in common. All three magnets share a common superconductor, collaring system, cryostat design, cold to warm support, cryogenic interface,more » burnout resistant current leads, DC power supply, quench protection, instrumentation and controls. The three magnets are collared, installed in cryostats and welded up and in various stages of final testing. The Q2 quadrupole is due to ship from France to America in August arriving during this ASC conference and has passed all final hipot, leak and pressure tests. The dipole is in leak and pressure testing as of July 2016 while the Q3 quadrupole requires some outer vacuum vessel assembly. Delivery of the Q3 and Dipole magnets will follow the Q2 at about 1 month intervals. Lastly, factory testing have included hipot and electrical tests, magnetic tests at low field, mechanical alignments to center the coils, leak tests and ASME Code required pressure tests. Upon installation in Hall C at JLAB cold testing will commence.« less

Analysis on Flexural Strength of A36 Mild Steel by Design of Experiment (DOE)

NASA Astrophysics Data System (ADS)

Nurulhuda, A.; Hafizzal, Y.; Izzuddin, MZM; Sulawati, MRN; Rafidah, A.; Suhaila, Y.; Fauziah, AR

2017-08-01

Nowadays demand for high quality and reliable components and materials are increasing so flexural tests have become vital test method in both the research and manufacturing process and development to explain in details about the material’s ability to withstand deformation under load. Recently, there are lack research studies on the effect of thickness, welding type and joint design on the flexural condition by DOE approach method. Therefore, this research will come out with the flexural strength of mild steel since it is not well documented. By using Design of Experiment (DOE), a full factorial design with two replications has been used to study the effects of important parameters which are welding type, thickness and joint design. The measurement of output response is identified as flexural strength value. Randomize experiments was conducted based on table generated via Minitab software. A normal probability test was carried out using Anderson Darling Test and show that the P-value is <0.005. Thus, the data is not normal since there is significance different between the actual data with the ideal data. Referring to the ANOVA, only factor joint design is significant since the P-value is less than 0.05. From the main plot and interaction plot, the recommended setting for each of parameters were suggested as high level for welding type, high level for thickness and low level for joint design. The prediction model was developed thru regression in order to measure effect of output response for any changes on parameters setting. In the future, the experiments can be enhanced using Taguchi methods in order to do verification of result.

Neural alpha oscillations index the balance between self-other integration and segregation in real-time joint action.

PubMed

Novembre, Giacomo; Sammler, Daniela; Keller, Peter E

2016-08-01

Shared knowledge and interpersonal coordination are prerequisites for most forms of social behavior. Influential approaches to joint action have conceptualized these capacities in relation to the separate constructs of co-representation (knowledge) and self-other entrainment (coordination). Here we investigated how brain mechanisms involved in co-representation and entrainment interact to support joint action. To do so, we used a musical joint action paradigm to show that the neural mechanisms underlying co-representation and self-other entrainment are linked via a process - indexed by EEG alpha oscillations - regulating the balance between self-other integration and segregation in real time. Pairs of pianists performed short musical items while action familiarity and interpersonal (behavioral) synchronization accuracy were manipulated in a factorial design. Action familiarity referred to whether or not pianists had rehearsed the musical material performed by the other beforehand. Interpersonal synchronization was manipulated via congruent or incongruent tempo change instructions that biased performance timing towards the impending, new tempo. It was observed that, when pianists were familiar with each other's parts, millisecond variations in interpersonal synchronized behavior were associated with a modulation of alpha power over right centro-parietal scalp regions. Specifically, high behavioral entrainment was associated with self-other integration, as indexed by alpha suppression. Conversely, low behavioral entrainment encouraged reliance on internal knowledge and thus led to self-other segregation, indexed by alpha enhancement. These findings suggest that alpha oscillations index the processing of information about self and other depending on the compatibility of internal knowledge and external (environmental) events at finely resolved timescales. Copyright © 2016 Elsevier Ltd. All rights reserved.

Design, fabrication and test of graphite/polyimide composite joints and attachments for advanced aerospace vehicles

NASA Technical Reports Server (NTRS)

1981-01-01

The development of several types of graphite/polyimide (GR/PI) bonded and bolted joints is reported. The program consists of two concurrent tasks: (1) design and test of specific built up attachments; and (2) evaluation of standard advanced bonded joint concepts. A data base for the design and analysis of advanced composite joints for use at elevated temperatures (561K (550 deg F)) to design concepts for specific joining applications, and the fundamental parameters controlling the static strength characteristics of such joints are evaluated. Data for design and build GR/PI of lightly loaded flight components for advanced space transportation systems and high speed aircraft are presented. Results for compression and interlaminar shear strengths of Celion 6000/PMR-15 laminates are given. Static discriminator test results for type 3 and type 4 bonded and bolted joints and final joint designs for TASK 1.4 scale up fabrication and testing are presented.

Corrosion behavior in high-temperature pressurized water of Zircaloy-4 joints brazed with Zr-Cu-based amorphous filler alloys

NASA Astrophysics Data System (ADS)

Lee, Jung Gu; Lee, Gyoung-Ja; Park, Jin-Ju; Lee, Min-Ku

2017-05-01

The compositional effects of ternary Zr-Cu-X (X: Al, Fe) amorphous filler alloys on galvanic corrosion susceptibility in high-temperature pressurized water were investigated for Zircaloy-4 brazed joints. Through an Al-induced microgalvanic reaction that deteriorated the overall nobility of the joint, application of the Zr-Cu-Al filler alloy caused galvanic coupling to develop readily between the Al-bearing joint and the Al-free base metal, finally leading to massive localized corrosion of the joint. Contrastingly, joints prepared with a Zr-Cu-Fe filler alloy showed excellent corrosion resistance comparable to that of the Zircaloy-4 base metal, since the Cu and Fe elements forming fine intermetallic particles with Zr did not influence the electrochemical stability of the resultant joints. The present results demonstrate that Fe is a more suitable alloying element than Al for brazing filler alloys subjected to high-temperature corrosive environments.

Modeling and optimization of joint quality for laser transmission joint of thermoplastic using an artificial neural network and a genetic algorithm

NASA Astrophysics Data System (ADS)

Wang, Xiao; Zhang, Cheng; Li, Pin; Wang, Kai; Hu, Yang; Zhang, Peng; Liu, Huixia

2012-11-01

A central composite rotatable experimental design(CCRD) is conducted to design experiments for laser transmission joining of thermoplastic-Polycarbonate (PC). The artificial neural network was used to establish the relationships between laser transmission joining process parameters (the laser power, velocity, clamp pressure, scanning number) and joint strength and joint seam width. The developed mathematical models are tested by analysis of variance (ANOVA) method to check their adequacy and the effects of process parameters on the responses and the interaction effects of key process parameters on the quality are analyzed and discussed. Finally, the desirability function coupled with genetic algorithm is used to carry out the optimization of the joint strength and joint width. The results show that the predicted results of the optimization are in good agreement with the experimental results, so this study provides an effective method to enhance the joint quality.

When Teaching Style Matches Students' Epistemic (In)Dependence: The Moderating Effect of Perceived Epistemic Gap

ERIC Educational Resources Information Center

Quiamzade, Alain; Mugny, Gabriel; Chatard, Armand

2009-01-01

In a 2x2x2 factorial design, 3rd year Romanian psychology students (N = 94) were assigned into 2 groups according to the extent to which they acknowledged an epistemic dependence (low vs. high) toward their professor. They then compared the competence of 3rd year students to that of 1st year or 5th year students. Finally, they were exposed to a…

The Fate of DDH Hips Showing Cartilaginous or Fibrous Tissue-filled Joint Spaces Following Primary Reduction.

PubMed

Kim, Hui Taek; Lee, Tae Hoon; Ahn, Tae Young; Jang, Jae Hoon

Because the use of magnetic resonance imaging is still not universal for the patients with developmental dysplasia of the hip patients, orthopaedists do not generally distinguish widened joint spaces which are "empty" after primary treatment (and therefore still reducible), from those which are filled and much more difficult to treat. To date no studies have focused on the latter hips. We treated and observed the outcomes for 19 hips which showed filled joint spaces after primary treatment. We retrospectively reviewed 19 cases of developmental dysplasia of the hip: (1) who showed a widened joint space on radiographs after primary treatment; and (2) whose magnetic resonance imaging showed that the widened joint space was accompanied by acetabular cartilage hypertrophy and/or was filled with fibrous tissues. All patients were over 1 year old at the time of primary reduction (reduction was closed in 4 patients, open in 6, and open with pelvic osteotomy in 9). Thirteen patients received at least 1 secondary treatment. Final results were classified using a modified Severin classification. Final outcomes were satisfactory in 10 (52.6%) and unsatisfactory in 9 (47.4%). The widened joint spaces gradually filled with bone, resulting in a shallow acetabulum in the patients with unsatisfactory results. Of 9 patients who underwent combined pelvic osteotomy at the time of primary reduction, results were satisfactory in 6 (66.7%), whereas all patients who had only closed or open primary reduction had unsatisfactory results. Combined pelvic osteotomy at the time of primary reduction is advisable in hips with widened joint spaces. However, hips with filled joint spaces after primary treatment often have unsatisfactory results even after additional pelvic and/or femoral osteotomy. Level IV-prognostic study.

47 CFR 53.213 - Audit analysis and evaluation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... auditor shall submit a draft of the audit report to the Federal/State joint audit team. (1) The Federal... auditor. Exceptions of the Federal/State joint audit team to the finding and conclusions of the independent auditor that remain unresolved shall be included in the final audit report. (2) Within 15 days...

47 CFR 53.213 - Audit analysis and evaluation.

Code of Federal Regulations, 2011 CFR

2011-10-01

... auditor shall submit a draft of the audit report to the Federal/State joint audit team. (1) The Federal... auditor. Exceptions of the Federal/State joint audit team to the finding and conclusions of the independent auditor that remain unresolved shall be included in the final audit report. (2) Within 15 days...

78 FR 22024 - Twenty First Meeting: RTCA Special Committee 216, Aeronautical Systems Security (Joint Meeting...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-12

... plenary Joint Plenary [cir] Subgroup status reports [cir] Review schedule and decide on readiness of documents for Final Review and Comment [cir] Identify next steps 3:00 p.m. (1500) Wrap-Up, Adjourn...: Monday, May 13, 2013 Introductions High-level document status Review level of maturity of contributions...

Minority Business Participation in Public/Private Partnerships: A Manual on Joint Development. Final Report.

ERIC Educational Resources Information Center

Beltran, Celestino M.; And Others

The Urban Mass Transportation Association promotes Commercial real estate development projects in and adjacent to transit facilities as a means of generating additional revenues to defray part of local transit agency operating cost. Transit-related real estate development, or joint development, provides unique financial benefits for investors and…

Pre-Launch Radiometric Performance Characterization of the Advanced Technology Microwave Sounder on the Joint Polar Satellite System-1 Satellite

NASA Technical Reports Server (NTRS)

Smith, Craig K.; Kim, Edward; Leslie, R. Vincent; Lyu, Joseph; McCormick, Lisa M.; Anderson, Kent

2017-01-01

The Advanced Technology Microwave Sounder (ATMS) is a space-based, cross-track radiometer for operational atmospheric temperature and humidity sounding, utilizing 22 channels over a frequency range from 23 to 183 gigahertz. The ATMS for the Joint Polar Satellite System-1 has undergone two rounds of re-work in 2014-2015 and 2016, following performance issues discovered during and following thermal vacuum chamber (TVAC) testing at the instrument and observatory level. Final shelf-level testing, including measurement of pass band characteristics and spectral response functions, was completed in December 2016. Final instrument-level TVAC testing and calibration occurred during February 2017. Here we will describe the instrument-level TVAC calibration process, and illustrate with results from the final TVAC calibration effort.

Assessment of Stress Corrosion Cracking Resistance of Activated Tungsten Inert Gas-Welded Duplex Stainless Steel Joints

NASA Astrophysics Data System (ADS)

Alwin, B.; Lakshminarayanan, A. K.; Vasudevan, M.; Vasantharaja, P.

2017-12-01

The stress corrosion cracking behavior of duplex stainless steel (DSS) weld joint largely depends on the ferrite-austenite phase microstructure balance. This phase balance is decided by the welding process used, heat input, welding conditions and the weld metal chemistry. In this investigation, the influence of activated tungsten inert gas (ATIG) and tungsten inert gas (TIG) welding processes on the stress corrosion cracking (SCC) resistance of DSS joints was evaluated and compared. Boiling magnesium chloride (45 wt.%) environment maintained at 155 °C was used. The microstructure and ferrite content of different weld zones are correlated with the outcome of sustained load, SCC test. Irrespective of the welding processes used, SCC resistance of weld joints was inferior to that of the base metal. However, ATIG weld joint exhibited superior resistance to SCC than the TIG weld joint. The crack initiation and final failure were in the weld metal for the ATIG weld joint; they were in the heat-affected zone for the TIG weld joint.

Final Report: Self-Consolidating Concrete Construction for Modular Units

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gentry, Russell; Kahn, Lawrence; Kurtis, Kimberly

This report focuses on work completed on DE-NE0000667, Self-Consolidating Concrete for Modular Units, in connection with the Department of Energy Nuclear Energy Enabling Technologies (DOE-NEET) program. This project was completed in the School of Civil and Environmental Engineering at the Georgia Institute of Technology, with Westinghouse Corporation as the industrial partner. The primary objective of this project was to develop self-consolidating concrete (also termed “self-compacting concrete” or SCC) mixtures so that concrete placement can be made into steel plate composite (SC) modular structures without the need for continuous concrete placement. As part of the research, SCC mixtures were developed andmore » validated to ensure sufficient shear capacity across cold-joints, while minimizing shrinkage and temperature increase during curing to enhance concrete bonding with the steel plate construction found in modular units. The SCC mixtures developed were able to carry shearing forces across the cold-joint boundaries. This “self-roughening” was achieved by adding a tailored fraction of lightweight aggregate (LWA) to the concrete mix, some of which raised to the surface during curing, forming a rough surface on which subsequent concrete placements were made. The self-roughening behavior was validated through three sets of structural tests. Shear friction on small-scale specimens with cold joints was assessed using varying fractions of LWA and with varying amounts of external steel plate reinforcement. The results show that the shear friction coefficient, to be used with the provisions of ACI 318-14, Section 22.9, can be taken as 1.35. Mid-scale beam tests were completed to assess the cold-joint capacity in both in-plane and out-of-plane bending. The results showed that the self-roughened joints performed as well as monolithic joints. The final assessment was a full-scale test using a steel composite module supplied by Westinghouse and similar in construction to the steel composite modules being assembled at the Vogtle and V.C. Summer plant expansions. The final test showed that the roughened cold-joint showed excellent shear and flexural capacity, and substantial ductility, when used in conjunction with steel composite construction.« less

76 FR 49786 - Notice of Availability of the Final Environmental Impact Statement/Environmental Impact Report...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-11

... of Fish and Game (CDFG), the lead State agency, have prepared a joint Final EIS/EIR for the proposed... decision. The CDFG will advance its recommendations to the California Fish and Game Commission (Commission...

Sugarcane bagasse lignin, and silica gel and magneto-silica as drug vehicles for development of innocuous methotrexate drug against rheumatoid arthritis disease in albino rats.

PubMed

Wahba, Sanaa M R; Darwish, Atef S; Shehata, Iman H; Abd Elhalem, Sahar S

2015-03-01

The present study clarifies co-therapy action of deliveries from their textural changes point of view. Methotrexate (MTX) was immobilized onto biodegradable lignin, silica gel and iron/silica nanocomposite. Loaded-MTX was i.p. injected into albino rats at doses of 0.25 and 0.5mg/kg/week for 2.5months, after which spleen, liver, testes and knee joint tissues were collected for tests. IFN-γ and IL-17A mRNA gene expressions in spleen in all biological samples were determined by RT-PCR. Physicochemical features of drug carriers were monitored by XRD, BET-PSD, SEM and TEM. Drug inflammatory-site targeting was found to be closely related to the physico-features of deliverers. The interlayered lignin of micro- and meso-pore channels directed MTX toward concealed infected cells in liver and testes tissues, while meso-structured silica flacks satisfied by gathering MTX around knee joints. The magneto-silica nanocomposite targeted MTX toward spleen tissue, which is considered as a lively factory for the production of electron rich compounds. Copyright © 2014 Elsevier B.V. All rights reserved.

Study for Updated Gout Classification Criteria (SUGAR): identification of features to classify gout

PubMed Central

Taylor, William J.; Fransen, Jaap; Jansen, Tim L.; Dalbeth, Nicola; Schumacher, H. Ralph; Brown, Melanie; Louthrenoo, Worawit; Vazquez-Mellado, Janitzia; Eliseev, Maxim; McCarthy, Geraldine; Stamp, Lisa K.; Perez-Ruiz, Fernando; Sivera, Francisca; Ea, Hang-Korng; Gerritsen, Martijn; Scire, Carlo; Cavagna, Lorenzo; Lin, Chingtsai; Chou, Yin-Yi; Tausche, Anne-Kathrin; Vargas-Santos, Ana Beatriz; Janssen, Matthijs; Chen, Jiunn-Horng; Slot, Ole; Cimmino, Marco A.; Uhlig, Till; Neogi, Tuhina

2015-01-01

Objective To determine which clinical, laboratory and imaging features most accurately distinguished gout from non-gout. Methods A cross-sectional study of consecutive rheumatology clinic patients with at least one swollen joint or subcutaneous tophus. Gout was defined by synovial fluid or tophus aspirate microscopy by certified examiners in all patients. The sample was randomly divided into a model development (2/3) and test sample (1/3). Univariate and multivariate association between clinical features and MSU-defined gout was determined using logistic regression modelling. Shrinkage of regression weights was performed to prevent over-fitting of the final model. Latent class analysis was conducted to identify patterns of joint involvement. Results In total, 983 patients were included. Gout was present in 509 (52%). In the development sample (n=653), these features were selected for the final model (multivariate OR) joint erythema (2.13), difficulty walking (7.34), time to maximal pain < 24 hours (1.32), resolution by 2 weeks (3.58), tophus (7.29), MTP1 ever involved (2.30), location of currently tender joints: Other foot/ankle (2.28), MTP1 (2.82), serum urate level > 6 mg/dl (0.36 mmol/l) (3.35), ultrasound double contour sign (7.23), Xray erosion or cyst (2.49). The final model performed adequately in the test set with no evidence of misfit, high discrimination and predictive ability. MTP1 involvement was the most common joint pattern (39.4%) in gout cases. Conclusion Ten key discriminating features have been identified for further evaluation for new gout classification criteria. Ultrasound findings and degree of uricemia add discriminating value, and will significantly contribute to more accurate classification criteria. PMID:25777045

Disease Characteristics and Rheumatoid Arthritis Development in Patients with Early Undifferentiated Arthritis: A 2-year Followup Study.

PubMed

Brinkmann, Gina H; Norli, Ellen S; Kvien, Tore K; Haugen, Anne J; Grøvle, Lars; Nygaard, Halvor; Bjørneboe, Olav; Thunem, Cathrine; Mjaavatten, Maria D; Lie, Elisabeth

2017-02-01

To examine the 2-year disease course in patients with undifferentiated arthritis (UA) focusing on fulfillment of the 2010 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) rheumatoid arthritis (RA) classification criteria. Data were provided by the Norwegian Very Early Arthritis Clinic study, which included patients presenting with ≥ 1 swollen joint of ≤ 16 weeks' duration. UA was defined as patients not fulfilling the 2010 ACR/EULAR RA criteria and who did not have a clinical diagnosis other than RA at baseline. The main outcome was fulfillment of the 2010 RA criteria. Secondary outcomes were disease-modifying antirheumatic drug (DMARD) use, resolution of synovitis without use of DMARD during followup, and final clinical diagnosis. We included 477 patients with UA of whom 47 fulfilled the 2010 ACR/EULAR RA criteria during followup (UA-RA) and 430 did not (UA-non-RA). Of the UA-RA patients, 70% fulfilled the criteria within the first 6 months. UA-RA patients were older, more often positive for rheumatoid factor and anticitrullinated protein antibodies, female, and ever smokers, and they more often presented with polyarticular arthritis, small joint involvement, and a swollen shoulder joint. During followup, 53% of UA-RA patients vs 13% of UA-non-RA patients used DMARD (p < 0.001). Overall, 71% of patients with UA achieved absence of clinical synovitis at final followup without use of DMARD. The most frequent final clinical diagnosis was UA (61%). Only 9.8% of patients with UA fulfilled the 2010 RA criteria during 2-year followup. Small joint involvement and swollen shoulder joint were among the factors associated with RA development. In two-thirds of patients with UA, the arthritis resolved without use of DMARD.

Flight motor set 360L007 (STS-33R)

NASA Technical Reports Server (NTRS)

Garecht, Diane

1990-01-01

Flight motor set 360L007 was launched as part of NASA space shuttle mission STS-33R. As with all previous redesigned solid rocket motor launches, overall motor performance was excellent. There were no debris concerns for either motor. Both motors exhibited unbonds on one factory joint weatherseal. All ballistics contract end item specification parameters were verified, with the exception of ignition interval and rise rates. Ignition interval and rise rates could not be verified due to the elimination of developmental flight instrumentation from fourth flight and subsequent, but the low sample rate data that were available showed nominal propulsion performance. All ballistic and mass property parameters closely matched the predicted values and were well within the required contract end item specification levels that could be assessed. All 108 Ground Environment Instrumentation (GEI) measurements performed properly throughout the prelaunch phase. Evaluation of the GEI measurements again verified thermal model analysis data and showed agreement with predicted environmental effects. No launch commit criteria thermal violations occurred. All joint heaters operated normally, but a high voltage reading was noted on the left hand aft heater, which was immediately determined to be a voltage sensor error and not a heater anomaly due to no current increase. Postflight inspection again verified superior performance of the insulation, phenolics, metal parts, and seals. Postflight evaluation indicated both nozzles performed as expected during flight. All combustion gas was contained by insulation in the field and case-to-nozzle joints.

76 FR 34212 - Notice of Availability of a Final General Conformity Determination and Record of Decision for the...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-13

... DEPARTMENT OF DEFENSE Department of the Army, Corps of Engineers Notice of Availability of a Final... Angeles, Los Angeles County, CA AGENCY: Department of the Army--U.S. Army Corps of Engineers, DoD. ACTION... Engineers (Corps) and the Los Angeles Harbor Department published a joint final Environmental Impact...

75 FR 9399 - Notice of Availability of a Final General Conformity Determination and Record of Decision for the...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-02

... DEPARTMENT OF DEFENSE Department of the Army Corps of Engineers Notice of Availability of a Final... of Long Beach, Los Angeles County, CA AGENCY: Department of the Army--U.S. Army Corps of Engineers... and published a joint Final Environmental Impact Statement/Environmental Impact Report (EIS/EIR) for...

A parametric shell analysis of the shuttle 51-L SRB AFT field joint

NASA Technical Reports Server (NTRS)

Davis, Randall C.; Bowman, Lynn M.; Hughes, Robert M., IV; Jackson, Brian J.

1990-01-01

Following the Shuttle 51-L accident, an investigation was conducted to determine the cause of the failure. Investigators at the Langley Research Center focused attention on the structural behavior of the field joints with O-ring seals in the steel solid rocket booster (SRB) cases. The shell-of-revolution computer program BOSOR4 was used to model the aft field joint of the solid rocket booster case. The shell model consisted of the SRB wall and joint geometry present during the Shuttle 51-L flight. A parametric study of the joint was performed on the geometry, including joint clearances, contact between the joint components, and on the loads, induced and applied. In addition combinations of geometry and loads were evaluated. The analytical results from the parametric study showed that contact between the joint components was a primary contributor to allowing hot gases to blow by the O-rings. Based upon understanding the original joint behavior, various proposed joint modifications are shown and analyzed in order to provide additional insight and information. Finally, experimental results from a hydro-static pressurization of a test rocket booster case to study joint motion are presented and verified analytically.

Performance Prediction of a MongoDB-Based Traceability System in Smart Factory Supply Chains

PubMed Central

Kang, Yong-Shin; Park, Il-Ha; Youm, Sekyoung

2016-01-01

In the future, with the advent of the smart factory era, manufacturing and logistics processes will become more complex, and the complexity and criticality of traceability will further increase. This research aims at developing a performance assessment method to verify scalability when implementing traceability systems based on key technologies for smart factories, such as Internet of Things (IoT) and BigData. To this end, based on existing research, we analyzed traceability requirements and an event schema for storing traceability data in MongoDB, a document-based Not Only SQL (NoSQL) database. Next, we analyzed the algorithm of the most representative traceability query and defined a query-level performance model, which is composed of response times for the components of the traceability query algorithm. Next, this performance model was solidified as a linear regression model because the response times increase linearly by a benchmark test. Finally, for a case analysis, we applied the performance model to a virtual automobile parts logistics. As a result of the case study, we verified the scalability of a MongoDB-based traceability system and predicted the point when data node servers should be expanded in this case. The traceability system performance assessment method proposed in this research can be used as a decision-making tool for hardware capacity planning during the initial stage of construction of traceability systems and during their operational phase. PMID:27983654

Performance Prediction of a MongoDB-Based Traceability System in Smart Factory Supply Chains.

PubMed

Kang, Yong-Shin; Park, Il-Ha; Youm, Sekyoung

2016-12-14

In the future, with the advent of the smart factory era, manufacturing and logistics processes will become more complex, and the complexity and criticality of traceability will further increase. This research aims at developing a performance assessment method to verify scalability when implementing traceability systems based on key technologies for smart factories, such as Internet of Things (IoT) and BigData. To this end, based on existing research, we analyzed traceability requirements and an event schema for storing traceability data in MongoDB, a document-based Not Only SQL (NoSQL) database. Next, we analyzed the algorithm of the most representative traceability query and defined a query-level performance model, which is composed of response times for the components of the traceability query algorithm. Next, this performance model was solidified as a linear regression model because the response times increase linearly by a benchmark test. Finally, for a case analysis, we applied the performance model to a virtual automobile parts logistics. As a result of the case study, we verified the scalability of a MongoDB-based traceability system and predicted the point when data node servers should be expanded in this case. The traceability system performance assessment method proposed in this research can be used as a decision-making tool for hardware capacity planning during the initial stage of construction of traceability systems and during their operational phase.

Particulate matters collected from ceramic factories in Lampang Province affecting rat lungs*

PubMed Central

Fongmoon, Duriya; Pongnikorn, Surathat; Chaisena, Aphiruk; Iamsaard, Sitthichai

2014-01-01

Background: Lung cancer ranks as the fifth largest of all cancer cases in Thailand. However, it is the first leading cancer in the northern part of Thailand (data from 2003–2007). There are several predisposing causes that lead to lung cancer and one important inducement is particulate matters (PMs). Lampang Province in Thailand is famous for the ceramic industry, where there are over 200 ceramic industrial factories. PMs are produced during the ceramic manufacturing process and spread throughout all of the working areas. It is very possible that workers could directly inhale PM-contaminated air during working hours. Objective: This study focuses on the toxic effects of PMs collected from ceramic factories on genes and lungs of rats. Methods: PMs collected from six ceramic factories in Lampang Province were extracted using dimethyl sulfoxide (DMSO). The inductively coupled plasma mass spectrometry (ICP-MS) and inductively coupled plasma optical emission spectrometry (ICP-OES) were used to analyze the chemical elements at lower and higher concentrations, respectively. Then, the toxicity of PMs on the genes was examined by the Ames test, and subsequently, the effect of PMs on DNA was examined by quantifying the amount of 8-hydroxy-2′-deoxyguanosine (8-OHdG). Finally, the toxicity of the PMs on rat’s lungs was examined by histology. Results: As chemical elements of lower concentrations, cadmium, chromium, nickel, copper, and lead were detected by ICP-MS. As chemical elements of higher concentrations, manganese, magnesium, zinc, iron, potassium, calcium, and sodium were detected by ICP-OES. No mutagenicity in Salmonella typhimurium was found in the PM extracts from all six factories by utilizing the Ames test. In the histological study, the reduction in spaces of alveolar ducts and sacs, and terminal bronchioles, the thickening of interstitial connective tissues were noted by PM extracts in high amounts (100 and 350 μg). Female rats were more sensitive to PM extracts than males in terms of their pulmonary damages. Conclusions: PMs were not mutagenic to S. typhimurium but can damage the lung tissue of rats. PMID:24390747

Determinants of Wood Dust Exposure in the Danish Furniture Industry—Results from Two Cross-Sectional Studies 6 Years Apart

PubMed Central

Schlünssen, Vivi; Jacobsen, Gitte; Erlandsen, Mogens; Mikkelsen, Anders B.; Schaumburg, Inger; Sigsgaard, Torben

2008-01-01

Objectives: This paper investigates determinants of wood dust exposure and trends in dust level in the furniture industry of Viborg County, Denmark, using data from two cross-sectional studies 6 years apart. Methods: During the winter 1997/1998, 54 factories were visited (hereafter study 1). In the winter 2003/2004, 27 factories were revisited, and personal dust measurements were repeated. In addition, 14 new factories were included (hereafter study 2). A total of 2303 woodworkers participated in study 1, and 2358 measurements from 1702 workers were available. From study 2, 1581 woodworkers participated and 1355 measurements from 1044 workers were available. Information on occupational variables describing potential determinants of exposures like work task, exhaust ventilation, enclosure and cleaning procedures were collected. A total of 2627 measurements and 1907 persons were included in the final mixed model in order to explore determinants of exposure and trends in dust level. Results: The overall inhalable wood dust concentration (geometric means (geometric standard deviation)) has decreased from 0.95 mg/m3 (2.05) in study 1 to 0.60 mg/m3 (1.63) in study 2, representing a 7% annual decrease in dust concentration, which was confirmed in the mixed model. From study 1 to study 2 there has been a change towards less manual work and more efficient cleaning methods, but on the contrary also more inadequate exhaust ventilation systems. The following determinants were found to ‘increase’ dust concentration: sanding; use of compressed air; use of full-automatic machines; manual work; cleaning of work pieces with compressed air; kitchen producing factories and small factories (<20 employees). The following determinants of exposure were found to ‘decrease’ dust concentration: manual assembling/packing; sanding with adequate exhaust ventilation; adequate exhaust ventilation; vacuum cleaning of machines and special cleaning staff. Conclusions: Despite a substantial drop in the dust concentration during the last 6 years in the furniture industry in Viborg County, further improvements are possible. There should be more focus on improved exhaust ventilation, professional cleaning methods and avoiding use of compressed air. PMID:18407937

Determinants of wood dust exposure in the Danish furniture industry--results from two cross-sectional studies 6 years apart.

PubMed

Schlünssen, Vivi; Jacobsen, Gitte; Erlandsen, Mogens; Mikkelsen, Anders B; Schaumburg, Inger; Sigsgaard, Torben

2008-06-01

This paper investigates determinants of wood dust exposure and trends in dust level in the furniture industry of Viborg County, Denmark, using data from two cross-sectional studies 6 years apart. During the winter 1997/1998, 54 factories were visited (hereafter study 1). In the winter 2003/2004, 27 factories were revisited, and personal dust measurements were repeated. In addition, 14 new factories were included (hereafter study 2). A total of 2303 woodworkers participated in study 1, and 2358 measurements from 1702 workers were available. From study 2, 1581 woodworkers participated and 1355 measurements from 1044 workers were available. Information on occupational variables describing potential determinants of exposures like work task, exhaust ventilation, enclosure and cleaning procedures were collected. A total of 2627 measurements and 1907 persons were included in the final mixed model in order to explore determinants of exposure and trends in dust level. The overall inhalable wood dust concentration (geometric means (geometric standard deviation)) has decreased from 0.95 mg/m(3) (2.05) in study 1 to 0.60 mg/m(3) (1.63) in study 2, representing a 7% annual decrease in dust concentration, which was confirmed in the mixed model. From study 1 to study 2 there has been a change towards less manual work and more efficient cleaning methods, but on the contrary also more inadequate exhaust ventilation systems. The following determinants were found to 'increase' dust concentration: sanding; use of compressed air; use of full-automatic machines; manual work; cleaning of work pieces with compressed air; kitchen producing factories and small factories (<20 employees). The following determinants of exposure were found to 'decrease' dust concentration: manual assembling/packing; sanding with adequate exhaust ventilation; adequate exhaust ventilation; vacuum cleaning of machines and special cleaning staff. Despite a substantial drop in the dust concentration during the last 6 years in the furniture industry in Viborg County, further improvements are possible. There should be more focus on improved exhaust ventilation, professional cleaning methods and avoiding use of compressed air.

Design of a Virtual Player for Joint Improvisation with Humans in the Mirror Game

PubMed Central

Zhai, Chao; Alderisio, Francesco; Tsaneva-Atanasova, Krasimira; di Bernardo, Mario

2016-01-01

Joint improvisation is often observed among humans performing joint action tasks. Exploring the underlying cognitive and neural mechanisms behind the emergence of joint improvisation is an open research challenge. This paper investigates jointly improvised movements between two participants in the mirror game, a paradigmatic joint task example. First, experiments involving movement coordination of different dyads of human players are performed in order to build a human benchmark. No designation of leader and follower is given beforehand. We find that joint improvisation is characterized by the lack of a leader and high levels of movement synchronization. Then, a theoretical model is proposed to capture some features of their interaction, and a set of experiments is carried out to test and validate the model ability to reproduce the experimental observations. Furthermore, the model is used to drive a computer avatar able to successfully improvise joint motion with a human participant in real time. Finally, a convergence analysis of the proposed model is carried out to confirm its ability to reproduce joint movements between the participants. PMID:27123927

Design of a Virtual Player for Joint Improvisation with Humans in the Mirror Game.

PubMed

Zhai, Chao; Alderisio, Francesco; Słowiński, Piotr; Tsaneva-Atanasova, Krasimira; di Bernardo, Mario

2016-01-01

Joint improvisation is often observed among humans performing joint action tasks. Exploring the underlying cognitive and neural mechanisms behind the emergence of joint improvisation is an open research challenge. This paper investigates jointly improvised movements between two participants in the mirror game, a paradigmatic joint task example. First, experiments involving movement coordination of different dyads of human players are performed in order to build a human benchmark. No designation of leader and follower is given beforehand. We find that joint improvisation is characterized by the lack of a leader and high levels of movement synchronization. Then, a theoretical model is proposed to capture some features of their interaction, and a set of experiments is carried out to test and validate the model ability to reproduce the experimental observations. Furthermore, the model is used to drive a computer avatar able to successfully improvise joint motion with a human participant in real time. Finally, a convergence analysis of the proposed model is carried out to confirm its ability to reproduce joint movements between the participants.

Total fume and metal concentrations during welding in selected factories in Jeddah, Saudi Arabia.

PubMed

Balkhyour, Mansour Ahmed; Goknil, Mohammad Khalid

2010-07-01

Welding is a major industrial process used for joining metals. Occupational exposure to welding fumes is a serious occupational health problem all over the world. The degree of risk to welder's health from fumes depends on composition, concentration, and the length of exposure. The aim of this study was to investigate workers' welding fume exposure levels in some industries in Jeddah, Saudi Arabia. In each factory, the air in the breathing zone within 0.5 m from welders was sampled during 8-hour shifts. Total particulates, manganese, copper, and molybdenum concentrations of welding fumes were determined. Mean values of eight-hour average particulate concentrations measured during welding at the welders breathing zone were 6.3 mg/m(3) (Factory 1), 5.3 mg/m(3) (Factory 2), 11.3 mg/m(3) (Factory 3), 6.8 mg/m(3) (Factory 4), 4.7 mg/m(3) (Factory 5), and 3.0 mg/m(3) (Factory 6). Mean values of airborne manganese, copper, and molybdenum levels measured during welding were in the range of 0.010 mg/m(3)-0.477 mg/m(3), 0.001 mg/m(3)-0.080 mg/m(3) and 0.001 mg/m(3)-0.058 mg/m(3) respectively. Mean values of calculated equivalent exposure values were: 1.50 (Factory 1), 1.56 (Factory 2), 5.14 (Factory 3), 2.21 (Factory 4), 2.89 (Factory 5), and 1.20 (Factory 6). The welders in factories 1, 2, 3, and 4 were exposed to welding fume concentration above the SASO limit value, which may increase the risk of respiratory health problems.

Open capsular and ligament reconstruction with semitendinosus hamstring autograft successfully controls superior and posterior translation for type V acromioclavicular joint dislocation.

PubMed

Garofalo, Raffaele; Ceccarelli, Enrico; Castagna, Alessandro; Calvisi, Vittorio; Flanagin, Brody; Conti, Marco; Krishnan, Sumant G

2017-07-01

Appropriate surgical management for type V complete acromioclavicular (AC) joint dislocation remains controversial. The purpose of this paper is to retrospectively report the clinical and radiographic outcomes of an open surgical technique consisting for AC joint ligamentous and capsular reconstruction using autologous hamstring tendon grafts and semi-permanent sutures. Between January 2005 and December 2011, 32 consecutive patients with symptomatic type V complete AC joint dislocation underwent surgical treatment using the same technique. The median time from injury to surgery was 45 days (range 24-90). The average median postoperative clinical and radiographic follow-up time was 30 months (range 24-33). Clinical outcomes measures included the ASES score, the visual analog score (VAS), and subjective patient satisfaction score. Minimum follow-up was 2 years. ASES score increased from a median of 38.2 ± 6.2 preoperative to 92.1 ± 4.7 postoperatively (p ≤ 0.05). The median VAS score improved from 62 mm (range 45-100 mm) preoperatively to 8 mm (range 0-20 mm) at final follow-up (p ≤ 0.05). No patient experienced pain or discomfort with either direct palpation of the AC joint or with cross-body adduction. Final radiographs demonstrated symmetric AC joint contour in 25/32 (78%) patients. Seven patients (22%) radiographically demonstrated superior translation of the distal clavicle relative to the superior margin of the acromion but less than 50% of the clavicular width. 30/32 patients (93%) were able to return to their pre-injury level of work and sports activities. This novel surgical technique using a free graft and braided suture for simultaneous coracoclavicular ligament and AC joint capsular reconstruction successfully controls superior and posterior translations after type V AC joint dislocation and minimizes the incidence of persistent postoperative AC joint subluxation. Retrospective case series, Level IV.

A simple model for factory distribution: Historical effect in an industry city

NASA Astrophysics Data System (ADS)

Uehara, Takashi; Sato, Kazunori; Morita, Satoru; Maeda, Yasunobu; Yoshimura, Jin; Tainaka, Kei-ichi

2016-02-01

The construction and discontinuance processes of factories are complicated problems in sociology. We focus on the spatial and temporal changes of factories at Hamamatsu city in Japan. Real data indicate that the clumping degree of factories decreases as the density of factory increases. To represent the spatial and temporal changes of factories, we apply "contact process" which is one of cellular automata. This model roughly explains the dynamics of factory distribution. We also find "historical effect" in spatial distribution. Namely, the recent factories have been dispersed due to the past distribution during the period of economic bubble. This effect may be related to heavy shock in Japanese stock market.

76 FR 23221 - Joint Public Roundtable on Issues Related to the Schedule for Implementing Final Rules for Swaps...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-26

... submissions will be reviewed jointly by the Agencies. All comments must be in English or be accompanied by an English translation. All submissions provided to either Agency in any electronic form or on paper will be... of CFTC Commissioner Scott D. O'Malia; Implementation Roundtable Seriatim; Certainty & Transparency I...

76 FR 81362 - Regulations Governing the Performance of Actuarial Services Under the Employee Retirement Income...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-28

... JOINT BOARD FOR THE ENROLLMENT OF ACTUARIES 20 CFR Part 901 [TD 9517] RIN 1545-BC82 Regulations...; Correction AGENCY: Joint Board for the Enrollment of Actuaries. ACTION: Correction to final regulations... Federal Register on Thursday, March 31, 2011 (76 FR 17762) relating to the enrollment of actuaries. DATES...

Depth and Motion Prediction for Earth Penetrators

DTIC Science & Technology

1978-06-01

multiple-layer targets. For targets with accurately knowni properties , the final-depth results are accurate ihný pret AM all13 EIIW FINVS S WLT n.- U lass S...Project hAl611o2AT2?, Task A2, Work Unit󈧊, " Effectiveness of Earth Penetrators in Various Geologic Environments." Mr. R. S. Bernard conducted the... effects in the selective destruction of localized targets (airfields, factories, utilities, etc.). The effectiveness of these weapons, however, is

Catalan's intriguing factorial problem

NASA Astrophysics Data System (ADS)

Koshy, Thomas

2012-01-01

This article investigates the numbers ? , originally studied by Catalan. We re-confirm that they are indeed integers. Using the close relationship between them and the Catalan numbers C n , we develop some divisibility properties for C n . In particular, we establish that ? , where f k denotes the kth Fermat number ? and M k the kth Mersenne number 2 k - 1. Finally, we develop an explicit formula for X m,n using Pascal's triangle and Catalan numbers, and extract several interesting byproducts from it.

EPA's Endangerment Finding: Paving the Way Toward the Next Generation of Cars and Trucks

EPA Pesticide Factsheets

View a fact sheet on how the Final Endangerment Finding will allow EPA to finalize the first greenhouse gas standards for new light-duty vehicles as part of the joint rulemaking with the Department of Transportation.

Tuning thermal mismatch between turbine rotor parts with a thermal medium

DOEpatents

Schmidt, Mark Christopher

2001-01-01

In a turbine rotor, an aft shaft wheel and the final-stage wheel of the rotor are coupled together, including by a rabbeted joint. During shutdown and startup of the turbine, a thermal mismatch between the aft shaft wheel and final-stage wheel is avoided by respectively heating and cooling the aft shaft wheel to maintain the thermal mismatch within acceptable limits, thereby avoiding opening of the rabbeted joint and the potential for unbalancing the rotor and rotor vibration. The thermal medium may be supplied by piping in the aft bearing cavity into the cavity between the forward closure plate and the aft shaft wheel.

Statistical moments in superposition models and strongly intensive measures

NASA Astrophysics Data System (ADS)

Broniowski, Wojciech; Olszewski, Adam

2017-06-01

First, we present a concise glossary of formulas for composition of standard, cumulant, factorial, and factorial cumulant moments in superposition (compound) models, where final particles are created via independent emission from a collection of sources. Explicit mathematical formulas for the composed moments are given to all orders. We discuss the composition laws for various types of moments via the generating-function methods and list the formulas for the unfolding of the unwanted fluctuations. Second, the technique is applied to the difference of the scaled multiplicities of two particle types. This allows for a systematic derivation and a simple algebraic interpretation of the so-called strongly intensive fluctuation measures. With the help of the formalism we obtain several new strongly intensive measures involving higher-rank moments. The reviewed as well as the new results may be useful in investigations of mechanisms of particle production and event-by-event fluctuations in high-energy nuclear and hadronic collisions, and in particular in the search for signatures of the QCD phase transition at a finite baryon density.

Occupational allergic rhinitis from guar gum.

PubMed

Kanerva, L; Tupasela, O; Jolanki, R; Vaheri, E; Estlander, T; Keskinen, H

1988-05-01

Three cases of allergic rhinitis from a vegetable gum, guar gum, have been detected. Two subjects were exposed to fine guar gum powder (Emco Gum 563, Meyhall Chemical AG, Switzerland), an insulator in rubber cables, when opening cables in a power cable laboratory. After 1-2 years' exposure the patients developed rhinitis. Scratch-chamber tests, nasal provocation tests, nasal eosinophilia and a RAST test proved their allergy. A third subject developed allergic rhinitis from another guar gum product (Meyproid 5306, Meyhall Chemical AG) after 2 years' exposure in a paper factory. A positive skin test and nasal provocation test confirmed the diagnosis. A fourth case of possible allergy to guar gum after exposure to Meyproid 5306 in a paper factory is also presented. No final diagnosis was reached in this case (in 1974). The present subjects, only one of whom was atopic, developed allergy within 2 years, although their exposure to guar gum was not especially heavy. Therefore, when handling guar, adequate ventilation facilities should be provided and protective clothing, including a respiratory mask, should be worn.

Final_report_pub1.pdf

DOE Office of Scientific and Technical Information (OSTI.GOV)

O'Brien, Nicholas

2014-08-15

The paper describes Soitecs project to plan,install,qualify and ramp a high volume CPV module manufactruing facility in Southern California. Soitec’s CPV module factory in San Diego was planned with an annual production capacity of 280MWDC. It was scheduled to be operational by the first quarter of 2013, and was expected to create several hundred direct and indirect jobs in the San Diego region. From ground breaking to facility readiness was completed in six months. This enabled the docking of equipment in the Q3’12 time frame. The first 140 MW of capacity was ready for operation in Q4’12. Production of themore » CX-M500 modules started in Q4 2012. The line yield and factory capacity were ramped in 2013. The annual production capacity demonstration was successfully completed in Q2 2014. The modules manufactured at the plant were used to supply utility scale demand in the US and also world markets.« less

The Strengths and Difficulties Questionnaire-Parents for Italian School-Aged Children: Psychometric Properties and Norms.

PubMed

Tobia, Valentina; Marzocchi, Gian Marco

2018-02-01

The Strengths and Difficulties Questionnaire [SDQ; (1)] is a multi-informant instrument for screening developmental psychopathology. This study contributes to the validation of the Italian SDQ-Parent version (SDQ-P), analyzing its factorial structure, providing norms and investigating cross-informant agreement (parents-teachers). The SDQ-P and the SDQ-Teacher version (SDQ-T) were completed for 1917 primary and middle school students. Confirmatory factor analyses were performed to compare two factorial structures: the original five-factor model and the structure obtained in a past Italian study (2). The original model showed the best fit. Significant differences by gender and school grade were found; norms were provided separately for males and females attending 1st-2nd, 3rd-5th and 6th-8th grades. Finally, the analysis of parent-teacher agreement showed correlations ranging from small (prosocial behavior) to large (hyperactivity-inattention). This study offers some reflections on the best way to use this instrument in a community sample.

Numerical built-in method for the nonlinear JRC/JCS model in rock joint.

PubMed

Liu, Qunyi; Xing, Wanli; Li, Ying

2014-01-01

The joint surface is widely distributed in the rock, thus leading to the nonlinear characteristics of rock mass strength and limiting the effectiveness of the linear model in reflecting characteristics. The JRC/JCS model is the nonlinear failure criterion and generally believed to describe the characteristics of joints better than other models. In order to develop the numerical program for JRC/JCS model, this paper established the relationship between the parameters of the JRC/JCS and Mohr-Coulomb models. Thereafter, the numerical implement method and implementation process of the JRC/JCS model were discussed and the reliability of the numerical method was verified by the shear tests of jointed rock mass. Finally, the effect of the JRC/JCS model parameters on the shear strength of the joint was analyzed.

Design, fabrication and test of graphite/polyimide composite joints and attachments for advanced aerospace vehicles

NASA Technical Reports Server (NTRS)

Skoumal, D. E.

1980-01-01

Bonded and bolted designs are presented for each of four major attachment types. Prepreg processing problems are discussed and quality control data are given for lots 2W4604, 2W4632 and 2W4643. Preliminary design allowables test results for tension tests and compression tests of laminates are included. The final small specimen test matrix is defined and the configuration of symmetric step-lap joint specimens are shown. Finite element modeling studies of a double lap joint were performed to evaluate the number of elements required through the adhesive thickness to assess effects of various joint parameters on stress distributions. Results of finite element analyses assessing the effect of an adhesive fillet on the stress distribution in a double lap joint are examined.

The structure and functioning of Dynastab DK - K fixator (knee joint) and its usefullness in clinical use.

PubMed

Deszczyński, J; Karpiński, J; Deszczyńska, H

1999-12-30

The autor describes following stages of research on external fixator Dynastab DK - K (knee joint) with in - built artificial joint enabling physiological range of movement of the knee and the use of the device in functional treatment of articular fractures of the knee. The final clinical prototype of the device was developed according to the results of the experiments with anatomical preparations of knee joints in which the trajectory of the physiological movement of the knee was stated. These observations were used to construct mechanical joint with the range of movement adequate to this of the healthy knee. The positive and negative aspects in DK - K fixator are also described. The fixator was appled in 6 difficult cases of articular fractures of knee with good results.

Review on failure prediction techniques of composite single lap joint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ab Ghani, A.F., E-mail: ahmadfuad@utem.edu.my; Rivai, Ahmad, E-mail: ahmadrivai@utem.edu.my

2016-03-29

Adhesive bonding is the most appropriate joining method in construction of composite structures. The use of reliable design and prediction technique will produce better performance of bonded joints. Several papers from recent papers and journals have been reviewed and synthesized to understand the current state of the art in this area. It is done by studying the most relevant analytical solutions for composite adherends with start of reviewing the most fundamental ones involving beam/plate theory. It is then extended to review single lap joint non linearity and failure prediction and finally on the failure prediction on composite single lap joint.more » The review also encompasses the finite element modelling part as tool to predict the elastic response of composite single lap joint and failure prediction numerically.« less

The National Shipbuilding Research Program, Computer Aided Process Planning for Shipyards

DTIC Science & Technology

1986-08-01

Factory Simulation with Conventional Factory Planning Techniques Financial Justification of State-of-the-Art Investment: A Study Using CAPP I–5 T I T L...and engineer to order.” “Factory Simulation: Approach to Integration of Computer- Based Factory Simulation with Conventional Factory Planning Techniques

Vascularised knee joint transplantation in man: the first two years experience.

PubMed

Kirschner, M H; Brauns, L; Gonschorek, O; Bühren, V; Hofmann, G O

2000-04-01

To describe our early experience with a new technique for restoring destroyed knee joints to give reasonable functional results. Observational clinical trial. Level-1-Trauma centre, Germany. 5 patients with large bone defects of the knee and loss of the extensor apparatus caused either by serious injury alone, or infection after serious injury. Transplantation of fresh and perfused knee joints with a vascular pedicle from multiorgan donors under immunosuppression. Ability to walk, need to remove one transplanted joint. Four patients are able to walk, the range of movement being from 50 degrees-120 degrees. The first patient additionally had to be provided with a total knee joint arthroplasty. In the third patient the graft became infected and had to be removed. She finally had an arthrodesis and bone lengthening by the Ilizarov technique. Transplantation of the knee joint may be an alternative to bone lengthening or amputation for patients with total loss of the extensor apparatus.

Prototype integration of the joint munitions assessment and planning model with the OSD threat methodology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lynn, R.Y.S.; Bolmarcich, J.J.

The purpose of this Memorandum is to propose a prototype procedure which the Office of Munitions might employ to exercise, in a supportive joint fashion, two of its High Level Conventional Munitions Models, namely, the OSD Threat Methodology and the Joint Munitions Assessment and Planning (JMAP) model. The joint application of JMAP and the OSD Threat Methodology provides a tool to optimize munitions stockpiles. The remainder of this Memorandum comprises five parts. The first is a description of the structure and use of the OSD Threat Methodology. The second is a description of JMAP and its use. The third discussesmore » the concept of the joint application of JMAP and OSD Threat Methodology. The fourth displays sample output of the joint application. The fifth is a summary and epilogue. Finally, three appendices contain details of the formulation, data, and computer code.« less

75 FR 25323 - Light-Duty Vehicle Greenhouse Gas Emission Standards and Corporate Average Fuel Economy Standards...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-07

...EPA and NHTSA are issuing this joint Final Rule to establish a National Program consisting of new standards for light-duty vehicles that will reduce greenhouse gas emissions and improve fuel economy. This joint Final Rule is consistent with the National Fuel Efficiency Policy announced by President Obama on May 19, 2009, responding to the country's critical need to address global climate change and to reduce oil consumption. EPA is finalizing greenhouse gas emissions standards under the Clean Air Act, and NHTSA is finalizing Corporate Average Fuel Economy standards under the Energy Policy and Conservation Act, as amended. These standards apply to passenger cars, light-duty trucks, and medium-duty passenger vehicles, covering model years 2012 through 2016, and represent a harmonized and consistent National Program. Under the National Program, automobile manufacturers will be able to build a single light-duty national fleet that satisfies all requirements under both programs while ensuring that consumers still have a full range of vehicle choices. NHTSA's final rule also constitutes the agency's Record of Decision for purposes of its National Environmental Policy Act (NEPA) analysis.

76 FR 76180 - Final Environmental Impact Statement/Environmental Impact Report (EIS/EIR) for the Suisun Marsh...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-06

...) Federal joint lead agencies, and the State of California Department of Fish and Game (DFG), acting as the..., Preservation, and Restoration Plan (SMP) Final EIS/EIR. The SMP is a comprehensive plan designed to address the...

[Divorce and joint physical custody].

PubMed

Golse, B

2014-04-01

This work first recalls the definition of joint physical custody, as well as the current legal procedure for obtaining it, its practical implementation, the financial implications for parents, and finally some statistics. Some psychological and psychopathological reflections on the impact of divorce on children are then presented before considering the question of joint physically custody with regard to attachment theory and depending on the age of the child (a great caution seems to be required before three years). The article concludes with a brief discussion of parental alienation syndrome. Copyright © 2014. Published by Elsevier SAS.

Generalized Cross Entropy Method for estimating joint distribution from incomplete information

NASA Astrophysics Data System (ADS)

Xu, Hai-Yan; Kuo, Shyh-Hao; Li, Guoqi; Legara, Erika Fille T.; Zhao, Daxuan; Monterola, Christopher P.

2016-07-01

Obtaining a full joint distribution from individual marginal distributions with incomplete information is a non-trivial task that continues to challenge researchers from various domains including economics, demography, and statistics. In this work, we develop a new methodology referred to as ;Generalized Cross Entropy Method; (GCEM) that is aimed at addressing the issue. The objective function is proposed to be a weighted sum of divergences between joint distributions and various references. We show that the solution of the GCEM is unique and global optimal. Furthermore, we illustrate the applicability and validity of the method by utilizing it to recover the joint distribution of a household profile of a given administrative region. In particular, we estimate the joint distribution of the household size, household dwelling type, and household home ownership in Singapore. Results show a high-accuracy estimation of the full joint distribution of the household profile under study. Finally, the impact of constraints and weight on the estimation of joint distribution is explored.

Ecology of Listeria spp. in a fish farm and molecular typing of Listeria monocytogenes from fish farming and processing companies.

PubMed

Miettinen, Hanna; Wirtanen, Gun

2006-11-01

This study focused on the ecology of Listeria monocytogenes in a fish farm by following the changes in its occurrence in different types of samples for a three year period. In addition, L. monocytogenes isolates from different seafood industry areas were compared with pulsed field gel electrophoresis (PFGE) typing to discover possible associations between primary production, further processing and final products. Weather conditions were found to have a strong influence on the probability of finding Listeria spp. in a fish farm environment. The number of samples contaminated with Listeria spp. was typically bigger after rainy periods. Brook and river waters as well as other runoff waters seemed to be the main contamination source at the farm studied. The farmed fish originally found to carry L. monocytogenes become gradually Listeria free. The time needed for the purification of the fish was several months. The sea bottom soil samples were the ones that preserved the L. monocytogenes contamination the longest time. It can be stated that the fish and fish farm equipment studied did not spread listeria contamination. On the contrary, they were found to suffer from listeria contamination coming from outside sources like the brook water. There was a wide range of different L. monocytogenes PFGE-pulsotypes (30) found at 15 Finnish fish farms and fish processing factories. L. monocytogenes isolates from the final products often belonged to the same pulsotypes as did the isolates from the processing environment as well as from the raw fish. This suggests that, in addition to the fish processing factory environment, the fish raw materials are important sources of L. monocytogenes contamination in final products.

Long-term auxological and pubertal outcome of patients with hereditary insulin-like growth factor-I deficiency (Laron and growth hormone-gene deletion syndrome) treated with recombinant human insulin-like growth factor-I.

PubMed

Messina, M F; Arrigo, T; Valenzise, M; Ghizzoni, L; Caruso-Nicoletti, M; Zucchini, S; Chiabotto, P; Crisafulli, G; Zirilli, G; De Luca, F

2011-04-01

GH-IGF-I axis is mainly involved in the complex process of somatic growth but emerging evidence suggests that it also influences hypothalamic-pituitary-gonadal (HPG) function. We report some data regarding long-term auxological and pubertal outcome of five female patients with hereditary forms of GH-IGF-I deficiency (Laron and GH-gene deletion syndrome) and a mean age of 23.4±5.3 yr (range 19-32). All the patients received recombinant human IGF-I (rhIGF-I, Pharmacia and Upjohn, Stockholm, Sweden, and rhIGF-I, Genentech, San Francisco, CA, USA) from a mean age of 8.6 yr (range 3.2-14.2) up to the final height. Final height was very disappointing (≤ -5.0 SD scores) and lower than target height in all the patients. Pubertal onset was delayed in most of them but menarche occurred spontaneously in all the patients. Median age at menarche was 15.1 yr. Menstrual cycles were regular for several years. Median duration of gynecological follow- up was 8.3 yr with the longest span of 17.2 yr. We can assert that GH-IGF-I axis has an essential role in promoting linear growth in humans and its physiological action cannot be replaced by pharmacological treatment in most patients with hereditary forms of IGF-I insufficiency as demonstrated by their subnormal final height. Our clinical observations can also support an essential role of IGF-I in genitalia growth but not in the function of HPG axis as demonstrated by the maintenance of regular menstrual cycles in the presence of subnormal levels of IGF-I after treatment discontinuation.

Multidisciplinary approach for in-deep assessment of joint prosthesis failure.

PubMed

Tessarolo, F; Caola, I; Piccoli, F; Dorigotti, P; Demattè, E; Molinari, M; Malavolta, M; Barbareschi, M; Caciagli, P; Nollo, G

2009-01-01

In spite of advancement in biomaterials and biomechanics, in development of new osteo-integrative materials and coatings, and in macro- micro- component design, a non negligible fraction of the implanted prosthesis fails before the expected lifetime. A prospective observational clinical study has been conducted to define and apply a set of experimental techniques to in-deep assess the failure of joint prosthesis. Microbiological, histological and micro-structural techniques were implemented to specifically address phenomena occurring at the tissue-implant interface. Results obtained from 27 cases of prosthetic joint failure are discussed in terms of sensitivity and specificity. A procedural flow-chart is finally proposed for the assessment of joint prosthesis failure.

Model-based estimation for dynamic cardiac studies using ECT.

PubMed

Chiao, P C; Rogers, W L; Clinthorne, N H; Fessler, J A; Hero, A O

1994-01-01

The authors develop a strategy for joint estimation of physiological parameters and myocardial boundaries using ECT (emission computed tomography). They construct an observation model to relate parameters of interest to the projection data and to account for limited ECT system resolution and measurement noise. The authors then use a maximum likelihood (ML) estimator to jointly estimate all the parameters directly from the projection data without reconstruction of intermediate images. They also simulate myocardial perfusion studies based on a simplified heart model to evaluate the performance of the model-based joint ML estimator and compare this performance to the Cramer-Rao lower bound. Finally, the authors discuss model assumptions and potential uses of the joint estimation strategy.

Toxicity interaction between chlorpyrifos, mancozeb and soil moisture to the terrestrial isopod Porcellionides pruinosus.

PubMed

Morgado, Rui G; Gomes, Pedro A D; Ferreira, Nuno G C; Cardoso, Diogo N; Santos, Miguel J G; Soares, Amadeu M V M; Loureiro, Susana

2016-02-01

A main source of uncertainty currently associated with environmental risk assessment of chemicals is the poor understanding of the influence of environmental factors on the toxicity of xenobiotics. Aiming to reduce this uncertainty, here we evaluate the joint-effects of two pesticides (chlorpyrifos and mancozeb) on the terrestrial isopod Porcellionides pruinosus under different soil moisture regimes. A full factorial design, including three treatments of each pesticide and an untreated control, were performed under different soil moisture regimes: 25%, 50%, and 75% WHC. Our results showed that soil moisture had no effects on isopods survival, at the levels assessed in this experiment, neither regarding single pesticides nor mixture treatments. Additivity was always the most parsimonious result when both pesticides were present. Oppositely, both feeding activity and biomass change showed a higher sensitivity to soil moisture, with isopods generally showing worse performance when exposed to pesticides and dry or moist conditions. Most of the significant differences between soil moisture regimes were found in single pesticide treatments, yet different responses to mixtures could still be distinguished depending on the soil moisture assessed. This study shows that while soil moisture has the potential to influence the effects of the pesticide mixture itself, such effects might become less important in a context of complex combinations of stressors, as the major contribution comes from its individual interaction with each pesticide. Finally, the implications of our results are discussed in light of the current state of environmental risk assessment procedures and some future perspectives are advanced. Copyright © 2015 Elsevier Ltd. All rights reserved.

Extensible Adaptable Simulation Systems: Supporting Multiple Fidelity Simulations in a Common Environment

NASA Technical Reports Server (NTRS)

McLaughlin, Brian J.; Barrett, Larry K.

2012-01-01

Common practice in the development of simulation systems is meeting all user requirements within a single instantiation. The Joint Polar Satellite System (JPSS) presents a unique challenge to establish a simulation environment that meets the needs of a diverse user community while also spanning a multi-mission environment over decades of operation. In response, the JPSS Flight Vehicle Test Suite (FVTS) is architected with an extensible infrastructure that supports the operation of multiple observatory simulations for a single mission and multiple mission within a common system perimeter. For the JPSS-1 satellite, multiple fidelity flight observatory simulations are necessary to support the distinct user communities consisting of the Common Ground System development team, the Common Ground System Integration & Test team, and the Mission Rehearsal Team/Mission Operations Team. These key requirements present several challenges to FVTS development. First, the FVTS must ensure all critical user requirements are satisfied by at least one fidelity instance of the observatory simulation. Second, the FVTS must allow for tailoring of the system instances to function in diverse operational environments from the High-security operations environment at NOAA Satellite Operations Facility (NSOF) to the ground system factory floor. Finally, the FVTS must provide the ability to execute sustaining engineering activities on a subset of the system without impacting system availability to parallel users. The FVTS approach of allowing for multiple fidelity copies of observatory simulations represents a unique concept in simulator capability development and corresponds to the JPSS Ground System goals of establishing a capability that is flexible, extensible, and adaptable.

NATO Allied Joint Medical Publication 7: Allied Joint Medical Doctrine for Support to Chemical, Biological, Radiological, and Nuclear (CBRN) Defensive Operations, Final Draft

DTIC Science & Technology

2014-07-31

A-1 ANNEX B REFERENCES .................................................................................... B-1 ANNEX C GLOSSARY ... Occupational and environmental health surveillance consists of the assessment and accounting of physical, chemical, biological, and radiological...assessment is based on environmental health hazard and threat assessment, as well on environmental, occupational and disease surveillance information

Development of the Joint Committee Standards for Evaluations of Educational Programs, Projects, and Materials.

ERIC Educational Resources Information Center

Diamond, Esther E.

The growing demand for program evaluation in the 1970s gave rise to a need for a comprehensive, carefully developed, objective set of guiding principles for the evaluation process, from initial planning to final report. The Joint Committee on Standards for Education Evaluation was established to meet this need. This broad-based group, representing…

The Case for a Joint Evaluation

DTIC Science & Technology

2017-01-01

intelligence, and engineering. Finally, the comparative time ex - pended by the combatant commanders (CCDRs) on fulfilling four different evaluation...template for the joint-centric construct would align with the four de facto sections noted earlier: an identifica- tion section, a performance metric...intangible or have not been properly researched. For example, under one evaluation system, a Servicemember’s separation or retire- ment into a post

The Joint Force in a Contested and Disordered World

DTIC Science & Technology

2016-07-14

environment. Next, Section 2 explores how the intersection and interaction of these changes might impact the character of war in the future. Finally, Section...ideas about how changes to conflict and war might impact the capabilities and operational approaches required by the future Joint Force. These...1 Colin Gray, Another Bloody Century, (2005), p. 43. 2 challenges that will impact the

75 FR 55313 - Final Environmental Impact Statement (FEIS) for Grow the Army Actions at Fort Lewis and the...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-10

... decisions in the 2007 Army Growth and Force Structure Realignment Programmatic EIS (also referred to as the... of Public Works, Attention: IMWE-LEW-PWE (Mr. Paul T. Steucke, Jr.), Building 2012, Liggett Avenue..., Yakima Training Center, and McChord Air Force Base were designated a joint base and renamed ``Joint Base...

77 FR 64483 - Circular Welded Carbon-Quality Steel Pipe from the Socialist Republic of Vietnam: Notice of Final...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-22

... Pipe from the Socialist Republic of Vietnam;'' ``Verification of the Sales Response of Midwest Air... Steel Joint Stock Company.... Sun Steel Joint Stock 4.57 Company. Huu Lien Asia Corporation........ Huu Lien Asia 4.57 Corporation. Hoa Phat Steel Pipe Co Hoa Phat Steel Pipe Co.. 4.57 Vietnam-Wide Rate \\13...

A parameters optimization method for planar joint clearance model and its application for dynamics simulation of reciprocating compressor

NASA Astrophysics Data System (ADS)

Hai-yang, Zhao; Min-qiang, Xu; Jin-dong, Wang; Yong-bo, Li

2015-05-01

In order to improve the accuracy of dynamics response simulation for mechanism with joint clearance, a parameter optimization method for planar joint clearance contact force model was presented in this paper, and the optimized parameters were applied to the dynamics response simulation for mechanism with oversized joint clearance fault. By studying the effect of increased clearance on the parameters of joint clearance contact force model, the relation of model parameters between different clearances was concluded. Then the dynamic equation of a two-stage reciprocating compressor with four joint clearances was developed using Lagrange method, and a multi-body dynamic model built in ADAMS software was used to solve this equation. To obtain a simulated dynamic response much closer to that of experimental tests, the parameters of joint clearance model, instead of using the designed values, were optimized by genetic algorithms approach. Finally, the optimized parameters were applied to simulate the dynamics response of model with oversized joint clearance fault according to the concluded parameter relation. The dynamics response of experimental test verified the effectiveness of this application.

1. VIEW TO SOUTHEAST (NORTHWEST CORNER OF EDIBLE FATS FACTORY) ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. VIEW TO SOUTHEAST (NORTHWEST CORNER OF EDIBLE FATS FACTORY) - Wilson's Oil House, Lard Refinery, & Edible Fats Factory, Edible Fats Factory, 2801 Southwest Fifteenth Street, Oklahoma City, Oklahoma County, OK

3. VIEW TO SOUTHWEST (NORTHEAST CORNER OF EDIBLE FATS FACTORY) ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. VIEW TO SOUTHWEST (NORTHEAST CORNER OF EDIBLE FATS FACTORY) - Wilson's Oil House, Lard Refinery, & Edible Fats Factory, Edible Fats Factory, 2801 Southwest Fifteenth Street, Oklahoma City, Oklahoma County, OK

Identifying seawater intrusion in coastal areas by means of 1D and quasi-2D joint inversion of TDEM and VES data

NASA Astrophysics Data System (ADS)

Martínez-Moreno, F. J.; Monteiro-Santos, F. A.; Bernardo, I.; Farzamian, M.; Nascimento, C.; Fernandes, J.; Casal, B.; Ribeiro, J. A.

2017-09-01

Seawater intrusion is an increasingly widespread problem in coastal aquifers caused by climate changes -sea-level rise, extreme phenomena like flooding and droughts- and groundwater depletion near to the coastline. To evaluate and mitigate the environmental risks of this phenomenon it is necessary to characterize the coastal aquifer and the salt intrusion. Geophysical methods are the most appropriate tool to address these researches. Among all geophysical techniques, electrical methods are able to detect seawater intrusions due to the high resistivity contrast between saltwater, freshwater and geological layers. The combination of two or more geophysical methods is recommended and they are more efficient when both data are inverted jointly because the final model encompasses the physical properties measured for each methods. In this investigation, joint inversion of vertical electric and time domain soundings has been performed to examine seawater intrusion in an area within the Ferragudo-Albufeira aquifer system (Algarve, South of Portugal). For this purpose two profiles combining electrical resistivity tomography (ERT) and time domain electromagnetic (TDEM) methods were measured and the results were compared with the information obtained from exploration drilling. Three different inversions have been carried out: single inversion of the ERT and TDEM data, 1D joint inversion and quasi-2D joint inversion. Single inversion results identify seawater intrusion, although the sedimentary layers detected in exploration drilling were not well differentiated. The models obtained with 1D joint inversion improve the previous inversion due to better detection of sedimentary layer and the seawater intrusion appear to be better defined. Finally, the quasi-2D joint inversion reveals a more realistic shape of the seawater intrusion and it is able to distinguish more sedimentary layers recognised in the exploration drilling. This study demonstrates that the quasi-2D joint inversion improves the previous inversions methods making it a powerful tool applicable to different research areas.

Pyomyositis of the iliacus muscle and pyogenic sacroiliitis after sacroiliac joint block -A case report-.

PubMed

Lee, Mi Hyeon; Byon, Hyo-Jin; Jung, Hyun Jun; Cha, Young-Deog; Lee, Doo Ik

2013-05-01

Sacroiliac joint block can be performed for the diagnosis and treatment of sacroiliac joint dysfunction. Although sacroiliac joint block is a common procedure, complications have not been reported in detail. We report a case of iliacus pyomyositis and sacroiliac joint infection following a sacroiliac joint block. A 70-year-old female patient received sacroiliac joint blocks to relieve pelvic pain. The patient was admitted to the emergency room two days after the final sacroiliac joint block (SIJB) with the chief complaints of left pelvic pain corresponding to a visual analogue scale (VAS) score of 9 and fever. A pelvic MRI indicated a diagnosis of myositis. After 1 month of continuous antibiotic therapy, the patient's erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) level remained elevated. A (67)Ga SPECT/CT was done. Abnormal uptake was seen at the left sacroiliac joint (SIJ), and septic sacroiliitis was suspected. The CRP normalized to 0.29 mg/dl and the ESR decreased to 60 mm/hr, and the patient had no fever after 57 days of antibiotic therapy. She was directed for follow up at an outpatient clinic.

Failure analysis of single-bolted joint for lightweight composite laminates and metal plate

NASA Astrophysics Data System (ADS)

Li, Linjie; Qu, Junli; Liu, Xiangdong

2018-01-01

A three-dimensional progressive damage model was developed in ANSYS to predict the damage accumulation of single bolted joint in composite laminates under in-plane tensile loading. First, we describe the formulation and algorithm of this model. Second, we calculate the failure loads of the joint in fibre reinforced epoxy laminated composite plates and compare it with the experiment results, which validates that our model can appropriately simulate the ultimate tensile strength of the joints and the whole process of failure of structure. Finally, this model is applied to study the failure process of the light-weight composite material (USN125). The study also has a great potential to provide a strong basis for bolted joints design in composite Laminates as well as a simple tool for comparing different laminate geometries and bolt arrangements.

4. SOUTHEAST CORNER OF EDIBLE FATS FACTORY (CONNECTING BUILDING ON ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. SOUTHEAST CORNER OF EDIBLE FATS FACTORY (CONNECTING BUILDING ON THE LEFT) - Wilson's Oil House, Lard Refinery, & Edible Fats Factory, Edible Fats Factory, 2801 Southwest Fifteenth Street, Oklahoma City, Oklahoma County, OK

"Type Ia Supernovae: Tools for Studying Dark Energy" Final Technical Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Woosley, Stan; Kasen, Dan

2017-05-10

Final technical report for project "Type Ia Supernovae: Tools for the Study of Dark Energy" awarded jointly to scientists at the University of California, Santa Cruz and Berkeley, for computer modeling, theory and data analysis relevant to the use of Type Ia supernovae as standard candles for cosmology.

50 CFR 424.19 - Final rules-impact analysis of critical habitat.

Code of Federal Regulations, 2012 CFR

2012-10-01

... habitat. 424.19 Section 424.19 Wildlife and Fisheries JOINT REGULATIONS (UNITED STATES FISH AND WILDLIFE... LISTING ENDANGERED AND THREATENED SPECIES AND DESIGNATING CRITICAL HABITAT Revision of the Lists § 424.19 Final rules—impact analysis of critical habitat. The Secretary shall identify any significant activities...

50 CFR 424.19 - Final rules-impact analysis of critical habitat.

Code of Federal Regulations, 2011 CFR

2011-10-01

... habitat. 424.19 Section 424.19 Wildlife and Fisheries JOINT REGULATIONS (UNITED STATES FISH AND WILDLIFE... LISTING ENDANGERED AND THREATENED SPECIES AND DESIGNATING CRITICAL HABITAT Revision of the Lists § 424.19 Final rules—impact analysis of critical habitat. The Secretary shall identify any significant activities...

Latex modified asphalt and experimental joint treatments on asphalt concrete overlays experimental project No. 3 : asphalt additives : final report.

DOT National Transportation Integrated Search

1991-06-01

This report documents the construction, initial evaluation and final evaluation of several experimental features which were incorporated as part of an overlay of an existing PCC pavement in order to determine the feasibility of extending the asphalti...

Final report and recommendations for research on human-automation interaction in the Next Generation Air Transportation System

DOT National Transportation Integrated Search

2006-11-01

This is the final report of an 18-month project to: (1) review Next Generation Air Transportation System (NGATS) Joint Planning and Development Office (JPDO) documents as they pertain to human-automation interaction; (2) review past system failures i...

77 FR 45652 - Final Program Environmental Impact Statement/Environmental Impact Report for the San Joaquin...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-01

... Department of Water Resources have prepared a joint Final Program Environmental Impact Statement... Department of Water Resources, South Central Region Office, 3374 East Shields Avenue, Fresno, California... of Water Resources (DWR), the U.S. Fish and Wildlife Service (FWS), the National Marine Fisheries...

Joint Hampton-Michigan Program for Training Minority and Women Researchers. Volume II of II Volumes. Final Report.

ERIC Educational Resources Information Center

Michigan Univ., Ann Arbor. School of Education.

The papers presented in this volume are the team research reports of the Joint Hampton-Michigan Program conducted in 1979-1980 for junior faculty members of the Hampton Institute (Virginia) and graduate students and faculty members of the University of Michigan. The titles of the papers are: (1) Social and Economic Implications of Teacher Training…

Web-Based Smoking-Cessation Program

PubMed Central

Strecher, Victor J.; McClure, Jennifer B.; Alexander, Gwen L.; Chakraborty, Bibhas; Nair, Vijay N.; Konkel, Janine M.; Greene, Sarah M.; Collins, Linda M.; Carlier, Carola C.; Wiese, Cheryl J.; Little, Roderick J.; Pomerleau, Cynthia S.; Pomerleau, Ovide F.

2009-01-01

Background Initial trials of web-based smoking-cessation programs have generally been promising. The active components of these programs, however, are not well understood. This study aimed to (1) identify active psychosocial and communication components of a web-based smoking-cessation intervention and (2) examine the impact of increasing the tailoring depth on smoking cessation. Design Randomized fractional factorial design. Setting Two HMOs: Group Health in Washington State and Henry Ford Health System in Michigan. Participants 1866 smokers. Intervention A web-based smoking-cessation program plus nicotine patch. Five components of the intervention were randomized using a fractional factorial design: high- versus low-depth tailored success story, outcome expectation, and efficacy expectation messages; high- versus low-personalized source; and multiple versus single exposure to the intervention components. Measurements Primary outcome was 7 day point-prevalence abstinence at the 6-month follow-up. Findings Abstinence was most influenced by high-depth tailored success stories and a high-personalized message source. The cumulative assignment of the three tailoring depth factors also resulted in increasing the rates of 6-month cessation, demonstrating an effect of tailoring depth. Conclusions The study identified relevant components of smoking-cessation interventions that should be generalizable to other cessation interventions. The study also demonstrated the importance of higher-depth tailoring in smoking-cessation programs. Finally, the use of a novel fractional factorial design allowed efficient examination of the study aims. The rapidly changing interfaces, software, and capabilities of eHealth are likely to require such dynamic experimental approaches to intervention discovery. PMID:18407003

Tensile and Fatigue Properties of Single and Multiple Dissimilar Welded Joints of DP980 and HSLA

NASA Astrophysics Data System (ADS)

Cui, Q. L.; Parkes, D.; Westerbaan, D.; Nayak, S. S.; Zhou, Y.; Saha, D. C.; Liu, D.; Goodwin, F.; Bhole, S.; Chen, D. L.

2017-02-01

The present study focused on single and multiple dissimilar joints between DP980 and high-strength low-alloy (HSLA) galvanized steels. The tensile properties of the dissimilar joint between the strong DP980 and the relatively soft HSLA reflected only the properties of HSLA with plastic deformation, and final fracture took place entirely in HSLA. The fatigue properties of the dissimilar joints were more intriguing, with the strong DP980 outperforming at high stress amplitude and the ductile HSLA outperforming at low stress amplitude. For different load amplitudes, fatigue failure occurred in different materials and at different locations. The fatigue strength of DP980 was more negatively impaired by weld defects than that of HSLA.

Model-based estimation for dynamic cardiac studies using ECT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chiao, P.C.; Rogers, W.L.; Clinthorne, N.H.

1994-06-01

In this paper, the authors develop a strategy for joint estimation of physiological parameters and myocardial boundaries using ECT (Emission Computed Tomography). The authors construct an observation model to relate parameters of interest to the projection data and to account for limited ECT system resolution and measurement noise. The authors then use a maximum likelihood (ML) estimator to jointly estimate all the parameters directly from the projection data without reconstruction of intermediate images. The authors also simulate myocardial perfusion studies based on a simplified heart model to evaluate the performance of the model-based joint ML estimator and compare this performancemore » to the Cramer-Rao lower bound. Finally, model assumptions and potential uses of the joint estimation strategy are discussed.« less

Exploring the joint measurability using an information-theoretic approach

NASA Astrophysics Data System (ADS)

Hsu, Li-Yi

2016-12-01

We explore the legal purity parameters for the joint measurements. Instead of direct unsharpening the measurements, we perform the quantum cloning before the sharp measurements. The necessary fuzziness in the unsharp measurements is equivalently introduced in the imperfect cloning process. Based on the information causality and the consequent noisy nonlocal computation, one can derive the information-theoretic quadratic inequalities that must be satisfied by any physical theory. On the other hand, to guarantee the classicality, the linear Bell-type inequalities deduced by these quadratic ones must be obeyed. As for the joint measurability, the purity parameters must be chosen to obey both types of inequalities. Finally, the quadratic inequalities for purity parameters in the joint measurability region are derived.

Review of sample preparation strategies for MS-based metabolomic studies in industrial biotechnology.

PubMed

Causon, Tim J; Hann, Stephan

2016-09-28

Fermentation and cell culture biotechnology in the form of so-called "cell factories" now play an increasingly significant role in production of both large (e.g. proteins, biopharmaceuticals) and small organic molecules for a wide variety of applications. However, associated metabolic engineering optimisation processes relying on genetic modification of organisms used in cell factories, or alteration of production conditions remain a challenging undertaking for improving the final yield and quality of cell factory products. In addition to genomic, transcriptomic and proteomic workflows, analytical metabolomics continues to play a critical role in studying detailed aspects of critical pathways (e.g. via targeted quantification of metabolites), identification of biosynthetic intermediates, and also for phenotype differentiation and the elucidation of previously unknown pathways (e.g. via non-targeted strategies). However, the diversity of primary and secondary metabolites and the broad concentration ranges encompassed during typical biotechnological processes means that simultaneous extraction and robust analytical determination of all parts of interest of the metabolome is effectively impossible. As the integration of metabolome data with transcriptome and proteome data is an essential goal of both targeted and non-targeted methods addressing production optimisation goals, additional sample preparation steps beyond necessary sampling, quenching and extraction protocols including clean-up, analyte enrichment, and derivatisation are important considerations for some classes of metabolites, especially those present in low concentrations or exhibiting poor stability. This contribution critically assesses the potential of current sample preparation strategies applied in metabolomic studies of industrially-relevant cell factory organisms using mass spectrometry-based platforms primarily coupled to liquid-phase sample introduction (i.e. flow injection, liquid chromatography, or capillary electrophoresis). Particular focus is placed on the selectivity and degree of enrichment attainable, as well as demands of speed, absolute quantification, robustness and, ultimately, consideration of fully-integrated bioanalytical solutions to optimise sample handling and throughput. Copyright © 2016 Elsevier B.V. All rights reserved.

Maximum aposteriori joint source/channel coding

NASA Technical Reports Server (NTRS)

Sayood, Khalid; Gibson, Jerry D.

1991-01-01

A maximum aposteriori probability (MAP) approach to joint source/channel coder design is presented in this paper. This method attempts to explore a technique for designing joint source/channel codes, rather than ways of distributing bits between source coders and channel coders. For a nonideal source coder, MAP arguments are used to design a decoder which takes advantage of redundancy in the source coder output to perform error correction. Once the decoder is obtained, it is analyzed with the purpose of obtaining 'desirable properties' of the channel input sequence for improving overall system performance. Finally, an encoder design which incorporates these properties is proposed.

Thermal conductance measurements of bolted copper joints for SuperCDMS

DOE PAGES

Schmitt, R. L.; Tatkowski, G.; Ruschman, M.; ...

2015-04-28

Joint thermal conductance testing has been undertaken for bolted copper to copper connections from 60 mK to 26 K. This testing was performed to validate an initial design basis for the SuperCDMS experiment, where a dilution refrigerator will be coupled to a cryostat via multiple bolted connections. Copper used during testing was either gold plated or passivated with citric acid to prevent surface oxidation. Finally, the results we obtained are well fit by a power law regression of joint thermal conductance to temperature and match well with data collected during a literature review.

Time-varying SMART design and data analysis methods for evaluating adaptive intervention effects.

PubMed

Dai, Tianjiao; Shete, Sanjay

2016-08-30

In a standard two-stage SMART design, the intermediate response to the first-stage intervention is measured at a fixed time point for all participants. Subsequently, responders and non-responders are re-randomized and the final outcome of interest is measured at the end of the study. To reduce the side effects and costs associated with first-stage interventions in a SMART design, we proposed a novel time-varying SMART design in which individuals are re-randomized to the second-stage interventions as soon as a pre-fixed intermediate response is observed. With this strategy, the duration of the first-stage intervention will vary. We developed a time-varying mixed effects model and a joint model that allows for modeling the outcomes of interest (intermediate and final) and the random durations of the first-stage interventions simultaneously. The joint model borrows strength from the survival sub-model in which the duration of the first-stage intervention (i.e., time to response to the first-stage intervention) is modeled. We performed a simulation study to evaluate the statistical properties of these models. Our simulation results showed that the two modeling approaches were both able to provide good estimations of the means of the final outcomes of all the embedded interventions in a SMART. However, the joint modeling approach was more accurate for estimating the coefficients of first-stage interventions and time of the intervention. We conclude that the joint modeling approach provides more accurate parameter estimates and a higher estimated coverage probability than the single time-varying mixed effects model, and we recommend the joint model for analyzing data generated from time-varying SMART designs. In addition, we showed that the proposed time-varying SMART design is cost-efficient and equally effective in selecting the optimal embedded adaptive intervention as the standard SMART design.

Recent Progress on Systems and Synthetic Biology Approaches to Engineer Fungi As Microbial Cell Factories.

PubMed

Amores, Gerardo Ruiz; Guazzaroni, María-Eugenia; Arruda, Letícia Magalhães; Silva-Rocha, Rafael

2016-04-01

Filamentous fungi are remarkable organisms naturally specialized in deconstructing plant biomass and this feature has a tremendous potential for biofuel production from renewable sources. The past decades have been marked by a remarkable progress in the genetic engineering of fungi to generate industry-compatible strains needed for some biotech applications. In this sense, progress in this field has been marked by the utilization of high-throughput techniques to gain deep understanding of the molecular machinery controlling the physiology of these organisms, starting thus the Systems Biology era of fungi. Additionally, genetic engineering has been extensively applied to modify wellcharacterized promoters in order to construct new expression systems with enhanced performance under the conditions of interest. In this review, we discuss some aspects related to significant progress in the understating and engineering of fungi for biotechnological applications, with special focus on the construction of synthetic promoters and circuits in organisms relevant for industry. Different engineering approaches are shown, and their potential and limitations for the construction of complex synthetic circuits in these organisms are examined. Finally, we discuss the impact of engineered promoter architecture in the single-cell behavior of the system, an often-neglected relationship with a tremendous impact in the final performance of the process of interest. We expect to provide here some new directions to drive future research directed to the construction of high-performance, engineered fungal strains working as microbial cell factories.

Multipacting in a grooved choke joint at SRF gun for BNL ERL prototype

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xu, W.; Ben-Zvi, I.; Belomestnykh, S.

2011-03-28

The 703 MHz superconducting gun for BNL ERL prototype was tested at JLab with and without choke-joint and cathode stalk. Without choke-joint and cathode stalk, the gradient reached was 25 MV/m with Q{sup 0} {approx} 6E9. The gun cathode insertion port is equipped with a grooved choke joint for multipacting suppression. We carried out tests with choke-joint and cathode stalk. The test results show that there are at least two barriers at about 3.5 MV/m and 5 MV/m. We considered several possibilities and finally found that fine details of the grooved shape are important for multipacting suppression. A triangular groovemore » with round crest may cause strong multipacting in the choke-joint at 3.5 MV/m, 5 MV/m and 10 MV/m. This paper presents the primary test results of the gun and discusses the multipacting analysis in the choke-joint. It also suggests possible solutions for the gun and multipacting suppressing for a similar structure.« less

Design/Analysis of the JWST ISIM Bonded Joints for Survivability at Cryogenic Temperatures

NASA Technical Reports Server (NTRS)

Bartoszyk, Andrew; Johnston, John; Kaprielian, Charles; Kuhn, Jonathan; Kunt, Cengiz; Rodini,Benjamin; Young, Daniel

1990-01-01

A major design and analysis challenge for the JWST ISIM structure is thermal survivability of metal/composite bonded joints below the cryogenic temperature of 30K (-405 F). Current bonded joint concepts include internal invar plug fittings, external saddle titanium/invar fittings and composite gusset/clip joints all bonded to M55J/954-6 and T300/954-6 hybrid composite tubes (75mm square). Analytical experience and design work done on metal/composite bonded joints at temperatures below that of liquid nitrogen are limited and important analysis tools, material properties, and failure criteria for composites at cryogenic temperatures are sparse in the literature. Increasing this challenge is the difficulty in testing for these required tools and properties at cryogenic temperatures. To gain confidence in analyzing and designing the ISIM joints, a comprehensive joint development test program has been planned and is currently running. The test program is designed to produce required analytical tools and develop a composite failure criterion for bonded joint strengths at cryogenic temperatures. Finite element analysis is used to design simple test coupons that simulate anticipated stress states in the flight joints; subsequently the test results are used to correlate the analysis technique for the final design of the bonded joints. In this work, we present an overview of the analysis and test methodology, current results, and working joint designs based on developed techniques and properties.

The SpeedCourt system in rehabilitation after reconstruction surgery of the anterior cruciate ligament (ACL).

PubMed

Bartels, Thomas; Proeger, Stefan; Brehme, Kay; Pyschik, Martin; Delank, Karl-Stefan; Schulze, Stephan; Schwesig, René; Fieseler, Georg

2016-07-01

This study aimed at evaluating and finding the advantages of a program with unexpected disturbances (reaction time beyond 200 ms) in the late rehabilitation (5 months) after ACL-surgery compared to current sensomotoric based concepts. 50 athletic patients (14 females, 36 males, age: 32.7 ± 10.0 years) were randomized and followed either a new training with the SpeedCourt (28 athletes) or underwent a regular stabilization program (22 athletes). Subjects were assessed at baseline and after 3 weeks, i.e. six sessions in total. The comparison of evaluations (pre- and post-training) was calculated with a two-factorial (time, group) univariate analysis with parameters for flexibility, reaction time, tapping, jump force (uni- and bi-lateral) and anthropometry. In between the two groups 5 out of 22 parameters (23 %) showed significant influences, i.e. highest in the lower leg dimensions 15 cm below joint-line of the operated knee joint (η (2) = 0.122), non-operated knee joint (η (2) = 0.200) and the lower leg dimensions 10 cm below joint-line of the non-operated knee joint (η (2) = 0.183). Jump height unilateral and reaction time on the surgically treated leg were also different and improved (η (2) = 0.148; η (2) = 0.138) significantly. Differences in the outcome parameters like tapping, jump height and ground reaction time between the operated and non-operated knee were remarkably reduced in the SpeedCourt intervention group. Interventional training programs with the SpeedCourt system seem to be advantageous in the late rehabilitation following ACL-knee surgery compared to current sensomotoric based concepts. We achieved improvements of anthropometric and functional parameters. Further studies with larger groups and longer periods of evaluation are necessary to support these data and to possibly establish a new innovative rehabilitation concept. Clinically, the demonstrated SpeedCourt system might help to determine the time "back/return to sports" for athletes more objectively and prospectively reduce the rate of ACL re-injuries.

Dataglove measurement of joint angles in sign language handshapes

PubMed Central

Eccarius, Petra; Bour, Rebecca; Scheidt, Robert A.

2012-01-01

In sign language research, we understand little about articulatory factors involved in shaping phonemic boundaries or the amount (and articulatory nature) of acceptable phonetic variation between handshapes. To date, there exists no comprehensive analysis of handshape based on the quantitative measurement of joint angles during sign production. The purpose of our work is to develop a methodology for collecting and visualizing quantitative handshape data in an attempt to better understand how handshapes are produced at a phonetic level. In this pursuit, we seek to quantify the flexion and abduction angles of the finger joints using a commercial data glove (CyberGlove; Immersion Inc.). We present calibration procedures used to convert raw glove signals into joint angles. We then implement those procedures and evaluate their ability to accurately predict joint angle. Finally, we provide examples of how our recording techniques might inform current research questions. PMID:23997644

Robust Control of a Cable-Driven Soft Exoskeleton Joint for Intrinsic Human-Robot Interaction.

PubMed

Jarrett, C; McDaid, A J

2017-07-01

A novel, cable-driven soft joint is presented for use in robotic rehabilitation exoskeletons to provide intrinsic, comfortable human-robot interaction. The torque-displacement characteristics of the soft elastomeric core contained within the joint are modeled. This knowledge is used in conjunction with a dynamic system model to derive a sliding mode controller (SMC) to implement low-level torque control of the joint. The SMC controller is experimentally compared with a baseline feedback-linearised proportional-derivative controller across a range of conditions and shown to be robust to un-modeled disturbances. The torque controller is then tested with six healthy subjects while they perform a selection of activities of daily living, which has validated its range of performance. Finally, a case study with a participant with spastic cerebral palsy is presented to illustrate the potential of both the joint and controller to be used in a physiotherapy setting to assist clinical populations.

Synchronization of Coupled Dynamical Systems: Tolerance to Weak Connectivity and Arbitrarily Bounded Time-Varying Delays

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meng, Ziyang; Yang, Tao; Li, Guoqi

Here, we study synchronization of coupled linear systems over networks with weak connectivity and nonuniform time-varying delays. We focus on the case where the internal dynamics are time-varying but non-expansive (stable dynamics with a quadratic Lyapunov function). Both uniformly jointly connected and infinitely jointly connected communication topologies are considered. A new concept of quadratic synchronization is introduced. We first show that global asymptotic quadratic synchronization can be achieved over directed networks with uniform joint connectivity and arbitrarily bounded delays. We then study the case of infinitely jointly connected communication topology. In particular, for the undirected communication topologies, it turns outmore » that the existence of a uniform time interval for the jointly connected communication topology is not necessary and quadratic synchronization can be achieved when the time-varying nonuniform delays are arbitrarily bounded. Finally, simulation results are provided to validate the theoretical results.« less

A Multi-Objective Advanced Design Methodology of Composite Beam-to-Column Joints Subjected to Seismic and Fire Loads

NASA Astrophysics Data System (ADS)

Pucinotti, Raffaele; Ferrario, Fabio; Bursi, Oreste S.

2008-07-01

A multi-objective advanced design methodology dealing with seismic actions followed by fire on steel-concrete composite full strength joints with concrete filled tubes is proposed in this paper. The specimens were designed in detail in order to exhibit a suitable fire behaviour after a severe earthquake. The major aspects of the cyclic behaviour of composite joints are presented and commented upon. The data obtained from monotonic and cyclic experimental tests have been used to calibrate a model of the joint in order to perform seismic simulations on several moment resisting frames. A hysteretic law was used to take into account the seismic degradation of the joints. Finally, fire tests were conducted with the objective to evaluate fire resistance of the connection already damaged by an earthquake. The experimental activity together with FE simulation demonstrated the adequacy of the advanced design methodology.

Synchronization of Coupled Dynamical Systems: Tolerance to Weak Connectivity and Arbitrarily Bounded Time-Varying Delays

DOE PAGES

Meng, Ziyang; Yang, Tao; Li, Guoqi; ...

2017-09-18

Here, we study synchronization of coupled linear systems over networks with weak connectivity and nonuniform time-varying delays. We focus on the case where the internal dynamics are time-varying but non-expansive (stable dynamics with a quadratic Lyapunov function). Both uniformly jointly connected and infinitely jointly connected communication topologies are considered. A new concept of quadratic synchronization is introduced. We first show that global asymptotic quadratic synchronization can be achieved over directed networks with uniform joint connectivity and arbitrarily bounded delays. We then study the case of infinitely jointly connected communication topology. In particular, for the undirected communication topologies, it turns outmore » that the existence of a uniform time interval for the jointly connected communication topology is not necessary and quadratic synchronization can be achieved when the time-varying nonuniform delays are arbitrarily bounded. Finally, simulation results are provided to validate the theoretical results.« less

Optimization of Laser Keyhole Welding Strategies of Dissimilar Metals by FEM Simulation

NASA Astrophysics Data System (ADS)

Garcia Navas, Virginia; Leunda, Josu; Lambarri, Jon; Sanz, Carmen

2015-07-01

Laser keyhole welding of dissimilar metals has been simulated to study the effect of welding strategies (laser beam displacements and tilts) and combination of metals to be welded on final quality of the joints. Molten pool geometry and welding penetration have been studied but special attention has been paid to final joint material properties, such as microstructure/phases and hardness, and especially to the residual stress state because it greatly conditions the service life of laser-welded components. For a fixed strategy (laser beam perpendicular to the joint) austenitic to carbon steel laser welding leads to residual stresses at the joint area very similar to those obtained in austenitic to martensitic steel welding, but welding of steel to Inconel 718 results in steeper residual stress gradients and higher area at the joint with detrimental tensile stresses. Therefore, when the difference in thermo-mechanical properties of the metals to be welded is higher, the stress state generated is more detrimental for the service life of the component, and consequently more relevant is the optimization of welding strategy. In laser keyhole welding of austenitic to martensitic stainless steel and austenitic to carbon steel, the optimum welding strategy is displacing the laser beam 1 mm toward the austenitic steel. In the case of austenitic steel to Inconel welding, the optimum welding strategy consists in setting the heat source tilted 45 deg and moved 2 mm toward the austenitic steel.

Myc Dynamically and Preferentially Relocates to a Transcription Factory Occupied by Igh

PubMed Central

Osborne, Cameron S; Chakalova, Lyubomira; Mitchell, Jennifer A; Horton, Alice; Wood, Andrew L; Bolland, Daniel J; Corcoran, Anne E; Fraser, Peter

2007-01-01

Transcription in mammalian nuclei is highly compartmentalized in RNA polymerase II-enriched nuclear foci known as transcription factories. Genes in cis and trans can share the same factory, suggesting that genes migrate to preassembled transcription sites. We used fluorescent in situ hybridization to investigate the dynamics of gene association with transcription factories during immediate early (IE) gene induction in mouse B lymphocytes. Here, we show that induction involves rapid gene relocation to transcription factories. Importantly, we find that the Myc proto-oncogene on Chromosome 15 is preferentially recruited to the same transcription factory as the highly transcribed Igh gene located on Chromosome 12. Myc and Igh are the most frequent translocation partners in plasmacytoma and Burkitt lymphoma. Our results show that transcriptional activation of IE genes involves rapid relocation to preassembled transcription factories. Furthermore, the data imply a direct link between the nonrandom interchromosomal organization of transcribed genes at transcription factories and the incidence of specific chromosomal translocations. PMID:17622196

New Materials for Electric Drive Vehicles - Final CRADA Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carter, J. David

This project was sponsored by the US DOE Global Initiatives for Proliferation Prevention. The object was for Ukrainian and US partners, including Argonne, AETC, and Dontech to develop special carbon materials and factory production equipment with the goal of making better car batteries to achieve DOE's goals for all-electric and plug-in hybrid electric vehicles. Carbon materials are used in designs for lithium-ion batteries and metal-air batteries, both leading contenders for future electric cars. Specifically, the collaborators planned to use the equipment derived from this project to develop a rechargeable battery system that will use the carbon materials produced by themore » innovative factory process equipment. The final outcome of the project was that the Ukrainian participants consisting of the Kharkov Institute of Physics and Technology (KIPT), the Institute of Gas of National Academy of Sciences of Ukraine and the Materials Research Center, Ltd. designed, built, tested and delivered 14 pieces of processing equipment for pilot scale carbon production lines at the AETC, Arlington Heights facilities. The pilot scale equipment will be used to process materials such as activated carbon, thermally expanded graphite and carbon coated nano-particles. The equipment was shipped from Ukraine to the United States and received by AETC on December 3, 2013. The equipment is on loan from Argonne, control # 6140. Plug-in hybrid electric vehicles (PHEV) and all-electric vehicles have already demostrated success in the U.S. as they begin to share the market with older hybrid electric designs. When the project was conceived, PHEV battery systems provided a ~40 mile driving range (2011 figures). DOE R&D targets increased this to >100 miles at reduced cost less than $250/kWh (2011 figures.) A 2016 Tesla model S has boasted 270 miles. The project object was to develop pilot-production line equipment for advanced hybrid battery system that achieves cycle life of 1000, an energy density of 280 Wh/kg and specific density of 600Wh/l. This project delivers factory equipment to produce these advanced battery materials.« less

Modeling Anisotropic Elastic Wave Propagation in Jointed Rock Masses

NASA Astrophysics Data System (ADS)

Hurley, R.; Vorobiev, O.; Ezzedine, S. M.; Antoun, T.

2016-12-01

We present a numerical approach for determining the anisotropic stiffness of materials with nonlinearly-compliant joints capable of sliding. The proposed method extends existing ones for upscaling the behavior of a medium with open cracks and inclusions to cases relevant to natural fractured and jointed rocks, where nonlinearly-compliant joints can undergo plastic slip. The method deviates from existing techniques by incorporating the friction and closure states of the joints, and recovers an anisotropic elastic form in the small-strain limit when joints are not sliding. We present the mathematical formulation of our method and use Representative Volume Element (RVE) simulations to evaluate its accuracy for joint sets with varying complexity. We then apply the formulation to determine anisotropic elastic constants of jointed granite found at the Nevada Nuclear Security Site (NNSS) where the Source Physics Experiments (SPE), a campaign of underground chemical explosions, are performed. Finally, we discuss the implementation of our numerical approach in a massively parallel Lagrangian code Geodyn-L and its use for studying wave propagation from underground explosions. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

[Dissolution behavior of Fuzi Lizhong pill based on simultaneous determination of two components in Glycyrrhizae Radix et Rhizoma].

PubMed

Jiang, Mao-Yuan; Zhang, Zhen; Shi, Jin-Feng; Zhang, Jin-Ming; Fu, Chao-Mei; Lin, Xia; Liu, Yu-Mei

2018-03-01

To preliminarily investigate the dissolution behavior of Fuzi Lizhong pill, provide the basis for its quality control and lay foundation for in vivo dissolution behavior by determining the dissolution rate of liquiritin and glycyrrhizic acid. High-performance liquid chromatography (HPLC) method for simultaneous content determination of the two active ingredients of liquiritin and glycyrrhizic acid in Fuzi Lizhong pill was established; The dissolution amount of these two active ingredients in fifteen batches of Fuzi Lizhong pill from five manufacturers was obtained at different time points, and then the cumulative dissolution rate was calculated and cumulative dissolution curve was drawn. The similarity of cumulative dissolution curve of different batches was evaluated based on the same factory, and the similarity of cumulative dissolution curve of different factories was evaluated based on the same active ingredients. The dissolution model of Fuzi Lizhong pill based on two kinds of active ingredients was established by fitting with the dissolution data. The best dissolution medium was 0.25% sodium lauryl sulfate. The dissolution behavior of liquiritin and glycyrrhizic acid in Fuzi Lizhong pill was basically the same and sustained release in 48 h. Three batches of the factories (factory 2, factory 3, factory 4 and factory 5) appeared to be similar in dissolution behavior, indicating similarity in dissolution behavior in most factories. Two of the three batches from factory 1 appeared to be not similar in dissolution behavior of liquiritin and glycyrrhizic acid. The dissolution data of the effective ingredients from different factories were same in fitting, and Weibull model was the best model in these batches. Fuzi Lizhong pill in 15 batches from 5 factories showed sustained release in 48 h, proving obviously slow releasing characteristics "pill is lenitive and keeps a long-time efficacy". The generally good dissolution behavior also suggested that quality of different batches from most factories was stable. The dissolution behavior of liquiritin and glycyrrhizic acid in different factories was different, suggesting that the source of medicinal materials and preparation technology parameters in five factories were different. Copyright© by the Chinese Pharmaceutical Association.

Entrepreneurship Education in the Arab States. Final Evaluation Report

ERIC Educational Resources Information Center

Lamloumi, Jilani

2013-01-01

The report involves the findings of the final evaluation of the regional entrepreneurship education project in Arab States component II (2011-2012) (see ED560497), which is a joint activity between UNESCO and StratREAL Foundation. It aims to help the development of educational policies enabling the integration of entrepreneurship education within…

Brandon Research, Inc. Orthopedic Implant Cooperative Research and Development Agreement (CRADA) Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Freeman, W.R.

1999-04-22

The project was a joint research effort between the U. S. Department of Energy's (DOE) Kansas City Plant (KCP) and Brandon Research, Inc. to develop ways to improve implants used for orthopedic surgery for joint replacement. The primary product produced by this study is design information, which may be used to develop implants that will improve long-term fixation and durability in the host bone environment.

The 1990-1991 project summaries

NASA Technical Reports Server (NTRS)

1991-01-01

Georgia Tech's School of Textile & Fiber Engineering and School of Mechanical Engineering participated in four cooperative design efforts this year. One group designed a thermal shield for a lunar telescope. The second group designed a selenotextile habitat shielding structure. The third group designed a pneumatically assisted elbow joint for the NASA zero-prebreathe suit (ZPS). The final group designed an electromechanical system to power an astronaut's finger joints. Summaries of these projects are presented.

The 1990-1991 project summaries

NASA Astrophysics Data System (ADS)

Georgia Tech's School of Textile & Fiber Engineering and School of Mechanical Engineering participated in four cooperative design efforts this year. One group designed a thermal shield for a lunar telescope. The second group designed a selenotextile habitat shielding structure. The third group designed a pneumatically assisted elbow joint for the NASA zero-prebreathe suit (ZPS). The final group designed an electromechanical system to power an astronaut's finger joints. Summaries of these projects are presented.

Summary of Prior Work on Joining of Oxide Dispersion-Strengthened Alloys

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wright, Ian G; Tatlock, Gordon J; Badairy, H.

2009-08-01

There is a range of joining techniques available for use with ODS alloys, but care should be exercised in matching the technique to the final duty requirements of the joint. The goal for joining ODS alloys is a joint with no local disruption of the distribution of the oxide dispersion, and no significant change in the size and orientation of the alloy microstructure. Not surprisingly, the fusion welding processes typically employed with wrought alloys produce the least satisfactory results with ODS alloys, but some versions, such as fusion spot welding, and the laser and electron-beam welding technologies, have demonstrated potentialmore » for producing sound joints. Welds made using solid-state spot welding reportedly have exhibited parent metal properties. Thus, it is possible to employ processes that result in significant disruption of the alloy microstructure, as long as the processing parameters are adjustment to minimize the extent of or influence of the changes in the alloy microstructure. Selection among these joining approaches largely depends on the particular application and component configuration, and an understanding of the relationships among processing, alloy microstructure, and final properties is key. Recent developments have resulted in friction welding evolving to be a prime method for joining ODS sheet products, and variants of brazing/diffusion bonding have shown excellent promise for use with tubes and pipes. The techniques that come closest to the goal defined above involve solid-state diffusion bonding and, in particular, it has been found that secondary recrystallization of joints made by pulsed plasma-assisted diffusion can produce the desired, continuous, large alloy grain structure through the joint. Such joints have exhibited creep rupture failure at >82% of the load needed to fail the monolithic parent alloy at 1000 C.« less

Sequence Factorial and Its Applications

ERIC Educational Resources Information Center

Asiru, Muniru A.

2012-01-01

In this note, we introduce sequence factorial and use this to study generalized M-bonomial coefficients. For the sequence of natural numbers, the twin concepts of sequence factorial and generalized M-bonomial coefficients, respectively, extend the corresponding concepts of factorial of an integer and binomial coefficients. Some latent properties…

Improving Kinematic Accuracy of Soft Wearable Data Gloves by Optimizing Sensor Locations

PubMed Central

Kim, Dong Hyun; Lee, Sang Wook; Park, Hyung-Soon

2016-01-01

Bending sensors enable compact, wearable designs when used for measuring hand configurations in data gloves. While existing data gloves can accurately measure angular displacement of the finger and distal thumb joints, accurate measurement of thumb carpometacarpal (CMC) joint movements remains challenging due to crosstalk between the multi-sensor outputs required to measure the degrees of freedom (DOF). To properly measure CMC-joint configurations, sensor locations that minimize sensor crosstalk must be identified. This paper presents a novel approach to identifying optimal sensor locations. Three-dimensional hand surface data from ten subjects was collected in multiple thumb postures with varied CMC-joint flexion and abduction angles. For each posture, scanned CMC-joint contours were used to estimate CMC-joint flexion and abduction angles by varying the positions and orientations of two bending sensors. Optimal sensor locations were estimated by the least squares method, which minimized the difference between the true CMC-joint angles and the joint angle estimates. Finally, the resultant optimal sensor locations were experimentally validated. Placing sensors at the optimal locations, CMC-joint angle measurement accuracies improved (flexion, 2.8° ± 1.9°; abduction, 1.9° ± 1.2°). The proposed method for improving the accuracy of the sensing system can be extended to other types of soft wearable measurement devices. PMID:27240364

Investigation of cadmium pollution in the spruce saplings near the metal production factory.

PubMed

Hashemi, Seyed Armin; Farajpour, Ghasem

2016-02-01

Toxic metals such as lead and cadmium are among the pollutants that are created by the metal production factories and disseminated in the nature. In order to study the quantity of cadmium pollution in the environment of the metal production factories, 50 saplings of the spruce species at the peripheries of the metal production factories were examined and the samples of the leaves, roots, and stems of saplings planted around the factory and the soil of the environment of the factory were studied to investigate pollution with cadmium. They were compared to the soil and saplings of the spruce trees planted outside the factory as observer region. The results showed that the quantity of pollution in the leaves, stems, and roots of the trees planted inside the factory environment were estimated at 1.1, 1.5, and 2.5 mg/kg, respectively, and this indicated a significant difference with the observer region (p < 0.05). The quantity of cadmium in the soil of the peripheries of the metal production factory was estimated at 6.8 mg/kg in the depth of 0-10 cm beneath the level of the soil. The length of roots in the saplings planted around the factory of metal production stood at 11 and 14.5 cm in the observer region which had a significant difference with the observer region (p < 0.05). The quantity of soil resources and spruce species' pollution with cadmium in the region has been influenced by the production processes in the factory. © The Author(s) 2013.

Joint research effort on vibrations of twisted plates, phase 1: Final results

NASA Technical Reports Server (NTRS)

Kielb, R. E.; Leissa, A. W.; Macbain, J. C.; Carney, K. S.

1985-01-01

The complete theoretical and experimental results of the first phase of a joint government/industry/university research study on the vibration characteristics of twisted cantilever plates are given. The study is conducted to generate an experimental data base and to compare many different theoretical methods with each other and with the experimental results. Plates with aspect ratios, thickness ratios, and twist angles representative of current gas turbine engine blading are investigated. The theoretical results are generated by numerous finite element, shell, and beam analysis methods. The experimental results are obtained by precision matching a set of twisted plates and testing them at two laboratories. The second and final phase of the study will concern the effects of rotation.

Testing Factorial Invariance in Multilevel Data: A Monte Carlo Study

ERIC Educational Resources Information Center

Kim, Eun Sook; Kwok, Oi-man; Yoon, Myeongsun

2012-01-01

Testing factorial invariance has recently gained more attention in different social science disciplines. Nevertheless, when examining factorial invariance, it is generally assumed that the observations are independent of each other, which might not be always true. In this study, we examined the impact of testing factorial invariance in multilevel…

Effects of selected bacterial cultures on safety and sensory traits of Nocellara Etnea olives produced at large factory scale.

PubMed

Randazzo, Cinzia L; Russo, Nunziatina; Pino, Alessandra; Mazzaglia, Agata; Ferrante, Margherita; Conti, Gea Oliveri; Caggia, Cinzia

2018-05-01

This work investigates the effects of different combinations of selected lactic acid bacteria strains on Lactobacillus species occurrence, on safety and on sensory traits of natural green table olives, produced at large factory scale. Olives belonging to Nocellara Etnea cv were processed in a 6% NaCl brine and inoculated with six different bacterial cultures, using selected strains belonging to Lactobacillus plantarum, Lactobacillus paracasei and Lactobacillus pentosus species. The fermentation process was strongly influenced by the added starters and the identification of lactic acid bacteria isolated throughout the process confirms that L. pentosus dominated all fermentations, followed by L. plantarum, whereas L. casei was never detected. Pathogens were never found, while histamine and tyrosine were detected in control and in two experimental samples. The samples with the lowest final pH values showed a safer profile and the most appreciated sensory traits. The present study highlights that selected starters promote prevalence of L. pentosus over the autochthonous microbiota throughout the whole process of Nocellara Etnea olives. Copyright © 2018. Published by Elsevier Ltd.

NR/EPDM elastomeric rubber blend miscibility evaluation by two-level fractional factorial design of experiment

NASA Astrophysics Data System (ADS)

Razak, Jeefferie Abd; Ahmad, Sahrim Haji; Ratnam, Chantara Thevy; Mahamood, Mazlin Aida; Yaakub, Juliana; Mohamad, Noraiham

2014-09-01

Fractional 25 two-level factorial design of experiment (DOE) was applied to systematically prepare the NR/EPDM blend using Haake internal mixer set-up. The process model of rubber blend preparation that correlates the relationships between the mixer process input parameters and the output response of blend compatibility was developed. Model analysis of variance (ANOVA) and model fitting through curve evaluation finalized the R2 of 99.60% with proposed parametric combination of A = 30/70 NR/EPDM blend ratio; B = 70°C mixing temperature; C = 70 rpm of rotor speed; D = 5 minutes of mixing period and E = 1.30 phr EPDM-g-MAH compatibilizer addition, with overall 0.966 desirability. Model validation with small deviation at +2.09% confirmed the repeatability of the mixing strategy with valid maximum tensile strength output representing the blend miscibility. Theoretical calculation of NR/EPDM blend compatibility is also included and compared. In short, this study provides a brief insight on the utilization of DOE for experimental simplification and parameter inter-correlation studies, especially when dealing with multiple variables during elastomeric rubber blend preparation.

The factorial invariance of the CES-D during adolescence: are symptom profiles for depression stable across gender and time?

PubMed

Verhoeven, Marjolein; Sawyer, Michael G; Spence, Susan H

2013-02-01

This study examined the factorial invariance of the Center for Epidemiologic Studies of Depression Scale (CES-D) across gender and time during adolescence. The factor structure of the CES-D was compared at four annual measurement waves in a community sample of 2650 Australian adolescents. Confirmatory factor analyses showed that the factor structure of the CES-D was generally invariant across gender and time. However, gender differences were found on three items: for all waves the item 'I had crying spells' was a stronger indicator for depressive affect in females than males. On the final three waves the item 'people were unfriendly' loaded significantly higher on the factor 'Interpersonal Relations' for males than females. On Wave 2 and 3 males interpreted the item 'everything I did was an effort' with a positive connotation, whereas females interpret it with a negative association. These gender-differences are discussed from both a theoretical and a methodological perspective. Copyright © 2012 The Foundation for Professionals in Services for Adolescents. Published by Elsevier Ltd. All rights reserved.

Utilization of red mud and bagasse for production of gas absorption materials

NASA Astrophysics Data System (ADS)

Thang, Nguyen Hoc; Quyen, Pham Vo Thi Ha; Nhung, Le Thuy; Phong, Dang Thanh; Tuyen, Nguyen Ngoc Kim

2018-04-01

Gas treatment or/and gas absorption is field which has more investigation from researchers. They are finding optimal solutions from catalyst or synthesized materials to obtain the best benefit for factories and community. This study would like to introduce a method to synthesis the gas absorption materials responding requirements for the process of gas treatment. More specially, raw materials used to produce the materials are industrial waste impacting negatively on the environment. In which, red mud is solid waste of Bayer process from bauxite mining which is being the hard problem to have solutions for its management and utilization, and bagasse is industrial waste of sugar factories. Both red mud and bagasse were dried, ground, and sieved and then mixed with bentonite and water for forming by wet pressing method. Continuously, the mixtures were passed processes of heat treatment at 400°C. The final samples were tested physic-chemical properties and characterized for microstructure. The productions were also tested for gas absorption capacity with data obtained very positive in comparison with others.

Application of synthetic biology for production of chemicals in yeast Saccharomyces cerevisiae.

PubMed

Li, Mingji; Borodina, Irina

2015-02-01

Synthetic biology and metabolic engineering enable generation of novel cell factories that efficiently convert renewable feedstocks into biofuels, bulk, and fine chemicals, thus creating the basis for biosustainable economy independent on fossil resources. While over a hundred proof-of-concept chemicals have been made in yeast, only a very small fraction of those has reached commercial-scale production so far. The limiting factor is the high research cost associated with the development of a robust cell factory that can produce the desired chemical at high titer, rate, and yield. Synthetic biology has the potential to bring down this cost by improving our ability to predictably engineer biological systems. This review highlights synthetic biology applications for design, assembly, and optimization of non-native biochemical pathways in baker's yeast Saccharomyces cerevisiae We describe computational tools for the prediction of biochemical pathways, molecular biology methods for assembly of DNA parts into pathways, and for introducing the pathways into the host, and finally approaches for optimizing performance of the introduced pathways. © FEMS 2015. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.

From gene to structure: The protein factory of the NBICS Centre of Kurchatov Institute

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boyko, K. M.; Lipkin, A. V.; Popov, V. O., E-mail: vpopov@inbi.ras.ru

2013-05-15

The Protein Factory was established at the Centre for Nano, Bio, Info, Cognitive, and Social Sciences and Technologies (NBICS Centre) of the National Research Centre 'Kurchatov Institute' in 2010. The Protein Factory, together with the Centre for Synchrotron Radiation and Nanotechnology, promote research on structural biology. This paper presents the technology platforms developed at the Protein Factory and the facilities available for researchers. The main projects currently being performed at the Protein Factory are briefly described.

[Application of pie-crusting the medial collateral ligament release in arthroscopic surgery for posterior horn of 
medial meniscus in knee joint].

PubMed

Zhu, Weihong; Tang, Qi; Liao, Lele; Li, Ding; Yang, Yang; Chen, You

2017-09-28

To explore the effectiveness and safety of pie-crusting the medial collateral ligament release (MCL) in treating posterior horn of medial meniscus (PHMM) tear in tight medial tibiofemoral compartment of knee joint.
 Methods: Thirty-two consecutive patients with PHMM tear in tight medial tibiofemoral compartment of knee joint were admitted to our department from January, 2013 to December, 2014. All patients were performed pie-crusting the MCL release at its tibial insertion with 18-gauge intravenous needle. All patients were evaluated by valgus stress test and bilateral valgus stress radiograph at postoperative 1st day, 4th week and 12th week. Visual Analogue Scales (VAS), Lysholm scores, Tegner scores and International Knee Documentation Committee (IKDC) scores were recorded at the 1st, 3th, 6th month follow-up, then follow-up every 6 months.
 Results: The mean follow-up was 28 (24-36) months. All cases were negative in valgus stress test. MCL rupture, femoral fracture, articular cartilage lesion and neurovascular injury were not found at the last follow-up. The median medial joint space width of affected side and unaffected side for valgus stress radiographs were 6.8 mm and 4.3 mm (P<0.05) at the 1st day, 5.5 mm and 4.2 mm 
(P<0.05) in the 4th week and 4.8 mm and 4.3 mm (P>0.05) at the 12th week, respectively. VAS scores was changed from 4.5±1.5 preoperatively to 1.7±1.0 at the final follow-up (t=16.561, P<0.05). Lysholm scores was changed from 52.3±5.8 preoperatively to 93.2±6.3 at the final follow-up (t=-41.353, P<0.05). Tegner scores was changed from 4.1±1.1 preoperatively to 5.5±0.6 at the final follow-up (t=-18.792, P<0.05). IKDC scores was changed from 54.5±6.2 preoperative to 93.8±4.5 at the final follow-up (t=-38.253, P<0.05).
 Conclusion: Pie-crusting the medial collateral ligament release is a safe, minimal invasive and effective surgical option for posterior horn of medial meniscus tear in tight medial tibiofemoral compartment of knee joint.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Henager, Jr., C. H.; Nguyen, Ba N.; Kurtz, Richard J.

The international fusion community has designed a miniature torsion specimen for neutron irradiation studies of joined SiC and SiC/SiC composite materials. For this research, miniature torsion joints based on this specimen design were fabricated using displacement reactions between Si and TiC to produce Ti 3SiC 2 + SiC joints with SiC and tested in torsion-shear prior to and after neutron irradiation. However, many miniature torsion specimens fail out-of-plane within the SiC specimen body, which makes it problematic to assign a shear strength value to the joints and makes it difficult to compare unirradiated and irradiated strengths to determine irradiation effects.more » Finite element elastic damage and elastic–plastic damage models of miniature torsion joints are developed that indicate shear fracture is more likely to occur within the body of the joined sample and cause out-of-plane failures for miniature torsion specimens when a certain modulus and strength ratio between the joint material and the joined material exists. The model results are compared and discussed with regard to unirradiated and irradiated test data for a variety of joint materials. The unirradiated data includes Ti 3SiC 2 + SiC/CVD-SiC joints with tailored joint moduli, and includes steel/epoxy and CVD-SiC/epoxy joints. Finally, the implications for joint data based on this sample design are discussed.« less

Approaching the socialist factory and its workforce: considerations from fieldwork in (former) Yugoslavia

PubMed Central

Archer, Rory; Musić, Goran

2017-01-01

Abstract The socialist factory, as the ‘incubator’ of the new socialist (wo)man, is a productive entry point for the study of socialist modernization and its contradictions. By outlining some theoretical and methodological insights gathered through field-research in factories in former Yugoslavia, we seek to connect the state of labour history in the Balkans to recent breakthroughs made by labour historians of other socialist countries. The first part of this article sketches some of the specificities of the Yugoslav self-managed factory and its heterogeneous workforce. It presents the ambiguous relationship between workers and the factory and demonstrates the variety of life trajectories for workers in Yugoslav state-socialism (from model communists to alienated workers). The second part engages with the available sources for conducting research inside and outside the factory advocating an approach which combines factory and local archives, print media and oral history. PMID:28190894

Approaching the socialist factory and its workforce: considerations from fieldwork in (former) Yugoslavia.

PubMed

Archer, Rory; Musić, Goran

2017-01-01

The socialist factory, as the 'incubator' of the new socialist (wo)man, is a productive entry point for the study of socialist modernization and its contradictions. By outlining some theoretical and methodological insights gathered through field-research in factories in former Yugoslavia, we seek to connect the state of labour history in the Balkans to recent breakthroughs made by labour historians of other socialist countries. The first part of this article sketches some of the specificities of the Yugoslav self-managed factory and its heterogeneous workforce. It presents the ambiguous relationship between workers and the factory and demonstrates the variety of life trajectories for workers in Yugoslav state-socialism (from model communists to alienated workers). The second part engages with the available sources for conducting research inside and outside the factory advocating an approach which combines factory and local archives, print media and oral history.

The Virtual Factory Teaching System (VFTS): Project Review and Results.

ERIC Educational Resources Information Center

Kazlauskas, E. J.; Boyd, E. F., III; Dessouky, M. M.

This paper presents a review of the Virtual Factory Teaching (VFTS) project, a Web-based, multimedia collaborative learning network. The system allows students, working alone or in teams, to build factories, forecast demand for products, plan production, establish release rules for new work into the factory, and set scheduling rules for…

Sequence Factorial of "g"-Gonal Numbers

ERIC Educational Resources Information Center

Asiru, Muniru A.

2013-01-01

The gamma function, which has the property to interpolate the factorial whenever the argument is an integer, is a special case (the case "g"?=?2) of the general term of the sequence factorial of "g"-gonal numbers. In relation to this special case, a formula for calculating the general term of the sequence factorial of any…

Commissioning Instrument for the GTC

NASA Astrophysics Data System (ADS)

Cuevas, S.; Sánchez, B.; Bringas, V.; Espejo, C.; Flores, R.; Chapa, O.; Lara, G.; Chavolla, A.; Anguiano, G.; Arciniega, S.; Dorantes, A.; González, J. L.; Montoya, J. M.; Toral, R.; Hernández, H.; Nava, R.; Devaney, N.; Castro, J.; Cavaller-Marqués, L.

2005-12-01

During the GTC integration phase, the Commissioning Instrument (CI) will be a diagnostic tool for performance verification. The CI features four operation modes: imaging, pupil imaging, Curvature WFS, and high resolution Shack-Hartmann WFS. This instrument was built by the Instituto de Astronomía UNAM and the Centro de Ingeniería y Desarrollo Industrial (CIDESI) under GRANTECAN contract after a public bid. In this paper we made a general instrument overview and we show some of the performance final results obtained when the Factory Acceptance tests previous to its transport to La Palma.

A survey of airborne and skin exposures to chemicals in footwear and equipment factories in Thailand.

PubMed

Todd, Lori A; Mottus, Kathleen; Mihlan, Gary J

2008-03-01

This research reports on a pilot industrial hygiene study that was performed at four footwear factories and two equipment factories in Thailand. Workers in these factories were exposed through inhalation and dermal contact to a large number of organic vapors from solvents and cements that were hand applied. In addition, these workers were exposed to highly toxic isocyanates primarily through the dermal route. A total of 286 personal air samples were obtained at the four footwear factories using organic vapor monitors; individual job tasks were monitored using a real-time MIRAN Spectrometer. A total of 64 surface, tool, or hand samples were monitored for isocyanates using surface contamination detectors. Real-time measurements were also obtained for organic vapors in two equipment factories. From 8% to 21% of the workers sampled in each footwear factory were overexposed to mixtures of chemicals from solvents and cements. Up to 100% of the workers performing specific job tasks were overexposed to mixtures of chemicals. From 39% to 69% of the surface samples were positive for unreacted isocyanates. Many of the real-time measurements obtained in the equipment factories exceeded occupational exposure limits. Personal protective equipment and engineering controls were inadequate in all of the factories.

Does open-air exposure to volatile organic compounds near a plastic recycling factory cause health effects?

PubMed

Yorifuji, Takashi; Noguchi, Miyuki; Tsuda, Toshihide; Suzuki, Etsuji; Takao, Soshi; Kashima, Saori; Yanagisawa, Yukio

2012-01-01

After a plastic reprocessing factory began to operate in August 2004, the residents around the factory in Neyagawa, Osaka, Japan, began to complain of symptoms. Therefore, we conducted an exposure assessment and a population-based epidemiological study in 2006. To assess exposure, volatile organic compounds (VOCs) and total VOCs were measured at two locations in the vicinity of the factory. In the population-based study, a total of 3,950 residents were targeted. A self-administered questionnaire was used to collect information about subjects' mucocutaneous or respiratory symptoms. Using logistic regression models, we compared the prevalence of symptoms in July 2006 by employing the farthest area from the factory as a reference, and prevalence odds ratios (PORs) and their 95% confidence intervals (CIs) were estimated. The concentration of total VOCs was higher in the vicinity of the factory. The prevalence of mucocutaneous and respiratory symptoms was the highest among the residents in the closest area to the factory. Some symptoms were significantly increased among the residents within 500 m of the factory compared with residents of an area 2800 m from the factory: e.g., sore throat (POR=3.2, 95% CI: 1.3-8.0), eye itch (POR=3.0, 95% CI: 1.5-6.0), eye discharge (POR=6.0, 95% CI: 2.3-15.9), eczema (POR=3.0, 95% CI: 1.1-7.9) and sputum (POR=2.4, 95% CI: 1.1-5.1). Despite of the limitations of this study, these results imply a possible association of open-air VOCs with mucocutaneous and respiratory symptoms. Because this kind of plasticre cycling factory only recently came into operation, more attention should be paid to the operation of plastic recycling factories in the environment.

Efficiency in Complexity: Composition and Dynamic Nature of Mimivirus Replication Factories

PubMed Central

Milrot, Elad; Mutsafi, Yael; Ben-Dor, Shifra; Levin, Yishai; Savidor, Alon; Kartvelishvily, Elena

2016-01-01

ABSTRACT The recent discovery of multiple giant double-stranded DNA (dsDNA) viruses blurred the consensual distinction between viruses and cells due to their size, as well as to their structural and genetic complexity. A dramatic feature revealed by these viruses as well as by many positive-strand RNA viruses is their ability to rapidly form elaborate intracellular organelles, termed “viral factories,” where viral progeny are continuously generated. Here we report the first isolation of viral factories at progressive postinfection time points. The isolated factories were subjected to mass spectrometry-based proteomics, bioinformatics, and imaging analyses. These analyses revealed that numerous viral proteins are present in the factories but not in mature virions, thus implying that multiple and diverse proteins are required to promote the efficiency of viral factories as “production lines” of viral progeny. Moreover, our results highlight the dynamic and highly complex nature of viral factories, provide new and general insights into viral infection, and substantiate the intriguing notion that viral factories may represent the living state of viruses. IMPORTANCE Large dsDNA viruses such as vaccinia virus and the giant mimivirus, as well as many positive-strand RNA viruses, generate elaborate cytoplasmic organelles in which the multiple and diverse transactions required for viral replication and assembly occur. These organelles, which were termed “viral factories,” are attracting much interest due to the increasing realization that the rapid and continuous production of viral progeny is a direct outcome of the elaborate structure and composition of the factories, which act as efficient production lines. To get new insights into the nature and function of viral factories, we devised a method that allows, for the first time, the isolation of these organelles. Analyses of the isolated factories generated at different times postinfection by mass spectrometry-based proteomics provide new perceptions of their role and reveal the highly dynamic nature of these organelles. PMID:27581975

Final Environmental Assessment: Demolition of Walson Hospital Complex at Joint Base McGuire-Dix-Lakehurst, New Jersey

DTIC Science & Technology

2012-06-01

westerly winds from the Ohio River Valley and nighttime reservoirs of pollutants from southern States along the Appalachian Mountain Range have...Joint Base McGuire-Dix-Lakehurst June 2012 iii List of Acronyms AFI Air Force Instruction APE Area of Potential Effect BMPs Best...Effect The Area of Potential Effect ( APE ) for architectural history and archaeology includes the area bounded by New Jersey Avenue, North Scott

Joint Typhoon Warning Center (JTWC92) Model.

DTIC Science & Technology

1992-05-01

Report Date. 13. Report Type and Dates Covered. I May 1992 IFinal - Contractor Report 4. Title and Subtitle. 5. FL iding Numbers. Final Report Joint...National Hurricane Center, Coral Gables, FL , 44 pp. I Neumann, C.J. and C.J. McAdie, 1991: A Revised National Hurricane Center NHC83 Model NHC90. NOAA...STATISTICAL-DYNAMICAL MODELS: HISTORICAL PERSPECTIVE The earliest known attempt at statistical-dynamical modeling is credi- ted to Veigas , (1966) for

Joint Ordnance Test Procedure (JOTP)-001 Allied Ammunition Safety and Suitability for Service Assessment Testing Publication - Guidance

DTIC Science & Technology

2013-01-08

hazard due to enemy attack or accident (e.g. Insensitive Munitions (IM) and Electromagnetic Environmental Effects (E3)) and the explosive materials...of mitigating potential explosive remnants of war hazards , particularly from unexploded ordnance , should be conducted. 6.5 Munition Software System...TYPE Final 3. DATES COVERED (From - To) 4. TITLE AND SUBTITLE Joint Ordnance Test Procedure (JOTP)-001 Allied Ammunition Safety and

DLI-IBM Joint Feasibility Study in Computer-Assisted Foreign Language Instruction. Final Report.

ERIC Educational Resources Information Center

Adams, Edward N.; Rosenbaum, Peter S.

This document is the final report on a study of the use of computer assisted instruction (CAI). The objective of the study was to evaluate the potential applicability and usefulness of CAI in the instructional environment of the Defense Language Institute (DLI). The operational phases of the study were implemented in the Russian Aural…

78 FR 32269 - Notice of Availability of the Final Environmental Impact Statement/Environmental Impact Report...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-29

..., state and local levels. While CDFW has participated in the development of this joint EIS/ EIR, the... alternatives on the human and physical environment, including, but not limited to, effects on biological... inspection at several libraries and government offices. A full list of locations where the final EIS/EIR is...

Design/analysis of the JWST ISIM bonded joints for survivability at cryogenic temperatures

NASA Astrophysics Data System (ADS)

Bartoszyk, Andrew; Johnston, John; Kaprielian, Charles; Kuhn, Jonathan; Kunt, Cengiz; Rodini, Benjamin; Young, Daniel

2005-08-01

A major design and analysis challenge for the JWST ISIM structure is thermal survivability of metal/composite adhesively bonded joints at the cryogenic temperature of 30K (-405°F). Current bonded joint concepts include internal invar plug fittings, external saddle titanium/invar fittings and composite gusset/clip joints all bonded to hybrid composite tubes (75mm square) made with M55J/954-6 and T300/954-6 prepregs. Analytical experience and design work done on metal/composite bonded joints at temperatures below that of liquid nitrogen are limited and important analysis tools, material properties, and failure criteria for composites at cryogenic temperatures are sparse in the literature. Increasing this challenge is the difficulty in testing for these required tools and properties at cryogenic temperatures. To gain confidence in analyzing and designing the ISIM joints, a comprehensive joint development test program has been planned and is currently running. The test program is designed to produce required analytical tools and develop a composite failure criterion for bonded joint strengths at cryogenic temperatures. Finite element analysis is used to design simple test coupons that simulate anticipated stress states in the flight joints; subsequently, the test results are used to correlate the analysis technique for the final design of the bonded joints. In this work, we present an overview of the analysis and test methodology, current results, and working joint designs based on developed techniques and properties.

Multi-channel feature dictionaries for RGB-D object recognition

NASA Astrophysics Data System (ADS)

Lan, Xiaodong; Li, Qiming; Chong, Mina; Song, Jian; Li, Jun

2018-04-01

Hierarchical matching pursuit (HMP) is a popular feature learning method for RGB-D object recognition. However, the feature representation with only one dictionary for RGB channels in HMP does not capture sufficient visual information. In this paper, we propose multi-channel feature dictionaries based feature learning method for RGB-D object recognition. The process of feature extraction in the proposed method consists of two layers. The K-SVD algorithm is used to learn dictionaries in sparse coding of these two layers. In the first-layer, we obtain features by performing max pooling on sparse codes of pixels in a cell. And the obtained features of cells in a patch are concatenated to generate patch jointly features. Then, patch jointly features in the first-layer are used to learn the dictionary and sparse codes in the second-layer. Finally, spatial pyramid pooling can be applied to the patch jointly features of any layer to generate the final object features in our method. Experimental results show that our method with first or second-layer features can obtain a comparable or better performance than some published state-of-the-art methods.

[The clinical evaluation of the lateral wedged insole fixed elastically on the subtalar joint of patients with osteoarthritis of the knee].

PubMed

Toda, Y

2001-06-01

We assessed the clinical efficacy of a lateral wedged insole with elastic fixation of the subtalar joint for conservative treatment of osteoarthritis of the knee. Novel insoles with elastic subtalar fixation (fixed insole) and a traditional shoe insert wedged insoles (inserted insole) were prepared. Seventy-one new female outpatients with osteoarthritis of the knee (knee OA) were treated with wedged insoles for 3 months. Randomization was performed according to birth date. The Severity Index of Lequesne, et al at the final assessment was compared with that at baseline in both the inserted and fixed insole groups. There were 37 participants in the inserted group and 34 participants in the fixed insole group. Regarding discomfort during nocturnal bed rest, 21 out of 34 (61%) participants were positive at the baseline assessment, however, only 8 out of 34 (27%) were positive at the final assessment in the fixed insole group (P = 0.033). In the fixed insole group, the number of participants complained immediate pain after walking was decreased from 28 (82%) at the baseline assessment to 17 (50%) at the final assessments (P = 0.0104). These significant differences were not found in the group with the inserted insole. Thus, clinical efficacy of lateral wedged insole may be emphasized with elastic fixation of the subtalar joint.

76 FR 77175 - New York Fun Factory Fireworks Display, Western Long Island Sound; Mamaroneck, NY

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-12

...-AA00 New York Fun Factory Fireworks Display, Western Long Island Sound; Mamaroneck, NY AGENCY: Coast... in support of the New York Fun Factory Fireworks display. This action is necessary to provide for the... the Coast Guard to define regulatory safety zones. On May 10, 2012 New York Fun Factory Events is...

Suitability of a three-dimensional model to measure empathy and its relationship with social and normative adjustment in Spanish adolescents: a cross-sectional study

PubMed Central

Gómez-Ortiz, Olga; Ortega-Ruiz, Rosario; Jolliffe, Darrick; Romera, Eva M.

2017-01-01

Objectives (1) To examine the psychometric properties of the Basic Empathy Scale (BES) with Spanish adolescents, comparing a two and a three-dimensional structure;(2) To analyse the relationship between the three-dimensional empathy and social and normative adjustment in school. Design Transversal and ex post facto retrospective study. Confirmatory factorial analysis, multifactorial invariance analysis and structural equations models were used. Participants 747 students (51.3% girls) from Cordoba, Spain, aged 12–17 years (M=13.8; SD=1.21). Results The original two-dimensional structure was confirmed (cognitive empathy, affective empathy), but a three-dimensional structure showed better psychometric properties, highlighting the good fit found in confirmatory factorial analysis and adequate internal consistent valued, measured with Cronbach’s alpha and McDonald’s omega. Composite reliability and average variance extracted showed better indices for a three-factor model. The research also showed evidence of measurement invariance across gender. All the factors of the final three-dimensional BES model were direct and significantly associated with social and normative adjustment, being most strongly related to cognitive empathy. Conclusions This research supports the advances in neuroscience, developmental psychology and psychopathology through a three-dimensional version of the BES, which represents an improvement in the original two-factorial model. The organisation of empathy in three factors benefits the understanding of social and normative adjustment in adolescents, in which emotional disengagement favours adjusted peer relationships. Psychoeducational interventions aimed at improving the quality of social life in schools should target these components of empathy. PMID:28951400

Energy: It is life

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arques, P.

1998-07-01

The relationships that seem to exist between energy and man are presented in this paper. Habitually, social coefficients are connected to the gross domestic product; some parameters with correlations are: birth rate, infant mortality rate, death rate, literacy, etc. Along with energy these define the optimal energy consumption per capita; the author presents the correlation between these parameters and energy consumed per capita. There exists a high correlation between energy consumption per capita and gross domestic product per capita. The set of parameters considered are correlated with similar values relative to these two parameters. Using data collected on a groupmore » of the different countries of the world, a table of 165 countries and 22 variables has been drawn up. From the [Country x variable] matrix, a correlation table is calculated and a factorial analysis is applied to this matrix. The first factorial plan comprises 57% of the information contained in this table. Results from this first factorial plan are presented. These parameters are analyzed: influence of a country's latitude on its inhabitants' consumption; relationship between consumed energy and gross domestic product; women's fertility rate; birth rate per 1000 population; sex ratio; life expectancy at birth; rate of literacy; death rate; population growth rate. Finally, it is difficult to define precise criteria for: an optimal distribution of population according to age, but with a power consumed of above 300 W per capita, the population becomes younger; the birth rate per 1000 population; the total fertility rate per woman; the population growth rate. The authors determine that optimal energy is approximately between 200 W and 677 W inclusive.« less

An approach to optimize sample preparation for MALDI imaging MS of FFPE sections using fractional factorial design of experiments.

PubMed

Oetjen, Janina; Lachmund, Delf; Palmer, Andrew; Alexandrov, Theodore; Becker, Michael; Boskamp, Tobias; Maass, Peter

2016-09-01

A standardized workflow for matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI imaging MS) is a prerequisite for the routine use of this promising technology in clinical applications. We present an approach to develop standard operating procedures for MALDI imaging MS sample preparation of formalin-fixed and paraffin-embedded (FFPE) tissue sections based on a novel quantitative measure of dataset quality. To cover many parts of the complex workflow and simultaneously test several parameters, experiments were planned according to a fractional factorial design of experiments (DoE). The effect of ten different experiment parameters was investigated in two distinct DoE sets, each consisting of eight experiments. FFPE rat brain sections were used as standard material because of low biological variance. The mean peak intensity and a recently proposed spatial complexity measure were calculated for a list of 26 predefined peptides obtained by in silico digestion of five different proteins and served as quality criteria. A five-way analysis of variance (ANOVA) was applied on the final scores to retrieve a ranking of experiment parameters with increasing impact on data variance. Graphical abstract MALDI imaging experiments were planned according to fractional factorial design of experiments for the parameters under study. Selected peptide images were evaluated by the chosen quality metric (structure and intensity for a given peak list), and the calculated values were used as an input for the ANOVA. The parameters with the highest impact on the quality were deduced and SOPs recommended.

[History of occupational health physician and industrial safety and health law].

PubMed

Horie, Seichi

2013-10-01

In Japan, an employer of a workplace with 50 or more employees is legally required to assign an occupational health physician. The assignment rate in 2010 was reported as 87.0%. This policy started with the provision of "factory physician"in the Factory Law in 1938, then the Labour Standard Law stipulated "physician hygienist" in 1947, and finally the Industrial Safety and Health Law defined "occupational health physician" in 1972. In 1996, a revision of the law then required those physicians to complete training courses in occupational medicine, as designated by an ordinance. Historically, an on-site physician was expected to cure injuries and to prevent communicable diseases of factory workers. The means of occupational hygienic management by working environment measurements, etc., and of health management by health examinations, etc., were developed. Localized exhaust ventilation and personal protection equipment became widely utilized. Qualification systems for non-medical experts in occupational hygiene were structured, and relationships between employers and occupational health physicians were stipulated in the legislative documents. Currently, the Japan Medical Association and the University of Occupational and Environmental Health, Japan educate and train occupational health physicians, and the Japan Society for Occupational Health maintains a specialized board certification system for these physicians. In the future, additional efforts should be made to strengthen the expertise of occupational health physicians, to define and recognize the roles of non-medical experts in occupational hygiene, to incorporate occupational health services in small enterprises, to promote occupational health risk assessment in the workplace, and to reorganize the current legislation, amended repeatedly over the decades.

Optimization of the Ion Source-Mass Spectrometry Parameters in Non-Steroidal Anti-Inflammatory and Analgesic Pharmaceuticals Analysis by a Design of Experiments Approach

NASA Astrophysics Data System (ADS)

Paíga, Paula; Silva, Luís M. S.; Delerue-Matos, Cristina

2016-10-01

The flow rates of drying and nebulizing gas, heat block and desolvation line temperatures and interface voltage are potential electrospray ionization parameters as they may enhance sensitivity of the mass spectrometer. The conditions that give higher sensitivity of 13 pharmaceuticals were explored. First, Plackett-Burman design was implemented to screen significant factors, and it was concluded that interface voltage and nebulizing gas flow were the only factors that influence the intensity signal for all pharmaceuticals. This fractionated factorial design was projected to set a full 22 factorial design with center points. The lack-of-fit test proved to be significant. Then, a central composite face-centered design was conducted. Finally, a stepwise multiple linear regression and subsequently an optimization problem solving were carried out. Two main drug clusters were found concerning the signal intensities of all runs of the augmented factorial design. p-Aminophenol, salicylic acid, and nimesulide constitute one cluster as a result of showing much higher sensitivity than the remaining drugs. The other cluster is more homogeneous with some sub-clusters comprising one pharmaceutical and its respective metabolite. It was observed that instrumental signal increased when both significant factors increased with maximum signal occurring when both codified factors are set at level +1. It was also found that, for most of the pharmaceuticals, interface voltage influences the intensity of the instrument more than the nebulizing gas flowrate. The only exceptions refer to nimesulide where the relative importance of the factors is reversed and still salicylic acid where both factors equally influence the instrumental signal.

The John Charnley Award Paper. The role of joint fluid in the tribology of total joint arthroplasty.

PubMed

Mazzucco, Daniel; Spector, Myron

2004-12-01

The effect of joint fluid on the tribology (ie, lubrication, friction, and wear) of total hip arthroplasty has not yet been investigated adequately. In the current study, a friction assay was used to assess four hypotheses relating to the effect of human joint fluid and its principal components on the articulation of metal-on-polyethylene. First, joint fluid was found to produce a widely varying amount of friction between cobalt-chromium and polyethylene; this range exceeded the range produced when the articulation was lubricated by water or bovine serum. Second, it was shown that hyaluronic acid, phospholipid, albumin, and gamma-globulin were not acting as boundary lubricants, but that one or more other proteins (as yet unidentified) were responsible for reducing friction in this couple. Third, lower friction was found when oxidized zirconium alloy replaced cobalt-chromium as a bearing surface on polyethylene. Finally, a pilot study suggested that lubricin, which contributes to cartilage-on-cartilage lubrication, is not a protein responsible for the tribological variabiation found among joint fluid samples. The current study showed that joint fluid is a patient factor that influences the tribology of metal-on-polyethylene arthroplasty.

Refinement of the β-Sn Grains in Ni-Doped Sn-3.0Ag-0.5Cu Solder Joints with Cu-Based and Ni-Based Substrates

NASA Astrophysics Data System (ADS)

Chou, Tzu-Ting; Chen, Wei-Yu; Fleshman, Collin Jordon; Duh, Jenq-Gong

2018-03-01

A fine-grain structure with random orientations of lead-free solder joints was successfully obtained in this study. The Sn-Ag-Cu solder alloys doped with minor Ni were reflowed with Ni-based or Cu-based substrates to fabricate the joints containing different Ni content. Adding 0.1 wt.% Ni into the solder effectively promoted the formation of fine Sn grains, and reflowing with Ni-based substrates further enhanced the effects of β-Sn grain refinement. The crystallographic characteristics and the microstructures were analyzed to identify the solidification mechanism of different types of microstructure in the joints. The phase precipitating order in the joint altered as the solder composition were modified by elemental doping and changing substrate, which significantly affected the efficiency of grain refinement and the final grain structure. The formation mechanism of fine β-Sn grains in the Ni-doped joint with a Ni-based substrate is attributable to the heterogeneous nucleation by Ni, whereas the Ni in the joint using ChouCu-based substrate is consumed to form an intermetallic compound and thus retard the effect of grain refining.

Mechanical testing and development of the helical field coil joint for the Advanced Toroidal Facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nelson, B.E.; Bryan, W.E.; Goranson, P.L.

1985-01-01

The helical field (HF) coil set for the Advanced Toroidal Facility (ATF) is an M = 12, l = 2, constant-ratio torsatron winding consisting of 2 coils, each with 14 turns of heavy copper conductor. The coils are divided into 24 identical segments to facilitate fabrication and minimize the assembly schedule. The segments are connected across through-bolted lap joints that must carry up to 124,000 A per turn for 5 s or 62,500 A steady-state. In addition, the joints must carry the high magnetic and thermal loads induced in the conductor and still fit within the basic 140- by 30-mmmore » copper envelope. Extensive testing and development were undertaken to verify and refine the basic joint design. Tests included assembly force and clamping force for various types of misalignment; joint resistance as a function of clamping force; clamp bolt relaxation due to thermal cycling; fatigue testing of full-size, multiturn joint prototypes; and low-cycle fatigue and tensile tests of annealed CDA102 copper. The required performance parameters and actual test results, as well as the final joint configuration, are presented. 2 refs., 9 figs., 4 tabs.« less

Human ossicular-joint flexibility transforms the peak amplitude and width of impulsive acoustic stimulia)

PubMed Central

Gottlieb, Peter K.; Vaisbuch, Yona

2018-01-01

The role of the ossicular joints in the mammalian middle ear is still debated. This work tests the hypothesis that the two synovial joints filter potentially damaging impulsive stimuli by transforming both the peak amplitude and width of these impulses before they reach the cochlea. The three-dimensional (3D) velocity along the ossicular chain in unaltered cadaveric human temporal bones (N = 9), stimulated with acoustic impulses, is measured in the time domain using a Polytec (Waldbronn, Germany) CLV-3D laser Doppler vibrometer. The measurements are repeated after fusing one or both of the ossicular joints with dental cement. Sound transmission is characterized by measuring the amplitude, width, and delay of the impulsive velocity profile as it travels from the eardrum to the cochlea. On average, fusing both ossicular joints causes the stapes velocity amplitude and width to change by a factor of 1.77 (p = 0.0057) and 0.78 (p = 0.011), respectively. Fusing just the incudomalleolar joint has a larger effect on amplitude (a factor of 2.37), while fusing just the incudostapedial joint decreases the stapes velocity on average. The 3D motion of the ossicles is altered by fusing the joints. Finally, the ability of current computational models to predict this behavior is also evaluated.

QM-8 final performance evaluation report: SEALS, volume 4

NASA Technical Reports Server (NTRS)

Nelsen, L. V.

1989-01-01

The Space Shuttle Redesigned Solid Rocket Motor (RSRM) static test of Qualification Motor-8 (QM-8) was conducted. The QM-8 test article was the fifth full-scale, full-duration test, and the third qualification motor to incorporate the redesigned case field joint and nozzle-to-case joint. This was the second static test conducted in the T-97 test facility, which is equipped with actuators for inducing external side loads to a 360 degree external tank (ET) attach ring during test motor operation, and permits heating/cooling of an entire motor. The QM-8 motor was cooled to a temperature which ensured that the maximum propellant mean bulk temperature (PMBT) of 40 F was achieved at firing. All test results are not included, but rather, the performance of the metal case, field joints, and nozzle-to-case joint is addressed. The involvement is studied of the Structural Applications and Structural Design Groups with the QM-8 test which includes: assembly procedures of the field and nozzle-to-case joints, joint leak check results, structural test results, and post-test inspection evaluations.

Recent Advances in Tissue Engineering Strategies for the Treatment of Joint Damage.

PubMed

Stephenson, Makeda K; Farris, Ashley L; Grayson, Warren L

2017-08-01

While the clinical potential of tissue engineering for treating joint damage has yet to be realized, research and commercialization efforts in the field are geared towards overcoming major obstacles to clinical translation, as well as towards achieving engineered grafts that recapitulate the unique structures, function, and physiology of the joint. In this review, we describe recent advances in technologies aimed at obtaining biomaterials, stem cells, and bioreactors that will enable the development of effective tissue-engineered treatments for repairing joint damage. 3D printing of scaffolds is aimed at improving the mechanical structure and microenvironment necessary for bone regeneration within a damaged joint. Advances in our understanding of stem cell biology and cell manufacturing processes are informing translational strategies for the therapeutic use of allogeneic and autologous cells. Finally, bioreactors used in combination with cells and biomaterials are promising strategies for generating large tissue grafts for repairing damaged tissues in pre-clinical models. Together, these advances along with ongoing research directions are making tissue engineering increasingly viable for the treatment of joint damage.

Structural characterization of a first-generation articulated-truss joint for space crane application

NASA Technical Reports Server (NTRS)

Sutter, Thomas R.; Wu, K. Chauncey; Riutort, Kevin T.; Laufer, Joseph B.; Phelps, James E.

1992-01-01

A first-generation space crane articulated-truss joint was statically and dynamically characterized in a configuration that approximated an operational environment. The articulated-truss joint was integrated into a test-bed for structural characterization. Static characterization was performed by applying known loads and measuring the corresponding deflections to obtain load-deflection curves. Dynamic characterization was performed using modal testing to experimentally determine the first six mode shapes, frequencies, and modal damping values. Static and dynamic characteristics were also determined for a reference truss that served as a characterization baseline. Load-deflection curves and experimental frequency response functions are presented for the reference truss and the articulated-truss joint mounted in the test-bed. The static and dynamic experimental results are compared with analytical predictions obtained from finite element analyses. Load-deflection response is also presented for one of the linear actuators used in the articulated-truss joint. Finally, an assessment is presented for the predictability of the truss hardware used in the reference truss and articulated-truss joint based upon hardware stiffness properties that were previously obtained during the Precision Segmented Reflector (PSR) Technology Development Program.

Limited distal clavicle excision of acromioclavicular joint osteoarthritis.

PubMed

Gokkus, K; Saylik, M; Atmaca, H; Sagtas, E; Aydin, A T

2016-05-01

Resection of the distal aspect of clavicle has a well-documented treatment modality in case of acromioclavicular joint osteoarthritis resistant to conservative treatment. Limited (mean ∼0.5cm distal end of clavicle resection) distal clavicle excision of A-C joint arthritis in cases resistant to conservative treatment may reduce the pain and improve the shoulder function. In this study, we retrospectively evaluated the results of limited distal clavicle excision of acromioclavicular joint osteoarthritis resistant to conservative treatment. All patients were evaluated by using the Visual Analogue Scale (VAS) and UCLA shoulder rating scale (University of California Los Angeles), either before surgery or final follow-up period for pain and functional results, respectively. A total of 110 patients (48 male, 62 female) with AC joint arthritis, treated between the years of 2008-2012, were retrospectively analyzed. A total of 30 patients (12 male, 18 female) who failed to show improvement with conservative treatment underwent limited surgical open excision of distal clavicle. The mean age of the study population was 52.5±1.2 years. The mean follow-up period was 27±1.3 months. The mean preoperative VAS score was 83.6±5.58 (range, 70-90) while mean VAS was 26.6±9.3 (range, 10-50) at the final follow-up. There was a statistically significant difference between pre- and postoperative VAS scores in patients who had treated by surgical approach (P<0.001). The mean UCLA score of the patients increased postoperatively from 11.5 (range, 9-14) to 29.2 (range, 27-32) at the final follow-up. There was a statistically significant difference between the two time periods with respect to UCLA scores (P<0.001). In patients with AC osteoarthritis resistant to conservative therapy, the hypothesized limited clavicle excision (mean ∼0.5cm distal end of clavicle resection with preserving coracoclavicular ligaments and inferior capsule) reduced the pain and improved the shoulder function. Our midterm follow-up (mean 27 months) results showed that limited distal clavicle excision of patients with AC joint osteoarthritis resistant to conservative treatment (0.5cm distal end of clavicle resection with preserving inferior capsule, and coracoclavicular ligaments) reduced the pain and improved the shoulder function. IV (Retrospective study). Copyright © 2016 Elsevier Masson SAS. All rights reserved.

Multimodal Speaker Diarization.

PubMed

Noulas, A; Englebienne, G; Krose, B J A

2012-01-01

We present a novel probabilistic framework that fuses information coming from the audio and video modality to perform speaker diarization. The proposed framework is a Dynamic Bayesian Network (DBN) that is an extension of a factorial Hidden Markov Model (fHMM) and models the people appearing in an audiovisual recording as multimodal entities that generate observations in the audio stream, the video stream, and the joint audiovisual space. The framework is very robust to different contexts, makes no assumptions about the location of the recording equipment, and does not require labeled training data as it acquires the model parameters using the Expectation Maximization (EM) algorithm. We apply the proposed model to two meeting videos and a news broadcast video, all of which come from publicly available data sets. The results acquired in speaker diarization are in favor of the proposed multimodal framework, which outperforms the single modality analysis results and improves over the state-of-the-art audio-based speaker diarization.

In situ industrial applications of optics; Proceedings of the Meeting, Brussels, Belgium, June 25-27, 1986

NASA Astrophysics Data System (ADS)

Ebbeni, Jean

Included in this volume are papers on real-time image enhancement by simple video systems, automatic identification and data collection via barcode laser scanning, the optimization of the cutting up of a strip of float glass, optical sensors for factory automation, and the use of a digital theodolite with infrared radiation. Attention is also given to ISIS (integrated shape imaging system), a new system for follow-up of scoliosis; optical diffraction extensometers; a cross-spectrum technique for high-sensitivity remote vibration analysis by optical interferometry; the compensation and measurement of any motion of three-dimensional objects in holographic interferometry; and stereoscreen. Additional papers are on holographic double pulse YAG lasers, miniature optic connectors, stress-field analysis in an adhesively bonded joint with laser photoelasticimetry, and the locking of the light pulse delay in externally triggered gas lasers.

Factorial Structure of the New Ecological Paradigm Scale in Two French Samples

ERIC Educational Resources Information Center

Fleury-Bahi, Ghozlane; Marcouyeux, Aurore; Renard, Elise; Roussiau, Nicolas

2015-01-01

The principal objective of this research is to test the factorial structure of the New Ecological Paradigm scale on a population of men and women residing in France. The tested model is a second-order factorial model. This factorial structure is evaluated on two separate samples to test the stability of the solution (a first sample of 253…

Do code of conduct audits improve chemical safety in garment factories? Lessons on corporate social responsibility in the supply chain from Fair Wear Foundation.

PubMed

Lindholm, Henrik; Egels-Zandén, Niklas; Rudén, Christina

2016-10-01

In managing chemical risks to the environment and human health in supply chains, voluntary corporate social responsibility (CSR) measures, such as auditing code of conduct compliance, play an important role. To examine how well suppliers' chemical health and safety performance complies with buyers' CSR policies and whether audited factories improve their performance. CSR audits (n = 288) of garment factories conducted by Fair Wear Foundation (FWF), an independent non-profit organization, were analyzed using descriptive statistics and statistical modeling. Forty-three per cent of factories did not comply with the FWF code of conduct, i.e. received remarks on chemical safety. Only among factories audited 10 or more times was there a significant increase in the number of factories receiving no remarks. Compliance with chemical safety requirements in garment supply chains is low and auditing is statistically correlated with improvements only at factories that have undergone numerous audits.

Do code of conduct audits improve chemical safety in garment factories? Lessons on corporate social responsibility in the supply chain from Fair Wear Foundation

PubMed Central

2016-01-01

Background In managing chemical risks to the environment and human health in supply chains, voluntary corporate social responsibility (CSR) measures, such as auditing code of conduct compliance, play an important role. Objectives To examine how well suppliers’ chemical health and safety performance complies with buyers’ CSR policies and whether audited factories improve their performance. Methods CSR audits (n = 288) of garment factories conducted by Fair Wear Foundation (FWF), an independent non-profit organization, were analyzed using descriptive statistics and statistical modeling. Results Forty-three per cent of factories did not comply with the FWF code of conduct, i.e. received remarks on chemical safety. Only among factories audited 10 or more times was there a significant increase in the number of factories receiving no remarks. Conclusions Compliance with chemical safety requirements in garment supply chains is low and auditing is statistically correlated with improvements only at factories that have undergone numerous audits. PMID:27611103

Lightweight structural design of a bolted case joint for the space shuttle solid rocket motor

NASA Technical Reports Server (NTRS)

Dorsey, John T.; Stein, Peter A.; Bush, Harold G.

1988-01-01

The structural design of a bolted joint with a static face seal which can be used to join Space Shuttle Solid Rocket Motor (SRM) case segments is given. Results from numerous finite element parametric studies indicate that the bolted joint meets the design requirement of preventing joint opening at the O-ring locations during SRM pressurization. A final design recommended for further development has the following parameters: 180 one-in.-diam. studs, stud centerline offset of 0.5 in radially inward from the shell wall center line, flange thickness of 0.75 in, bearing plate thickness of 0.25 in, studs prestressed to 70 percent of ultimate load, and the intermediate alcove. The design has a mass penalty of 1096 lbm, which is 164 lbm greater than the currently proposed capture tang redesign.

Mechanical performance and parameter sensitivity analysis of 3D braided composites joints.

PubMed

Wu, Yue; Nan, Bo; Chen, Liang

2014-01-01

3D braided composite joints are the important components in CFRP truss, which have significant influence on the reliability and lightweight of structures. To investigate the mechanical performance of 3D braided composite joints, a numerical method based on the microscopic mechanics is put forward, the modeling technologies, including the material constants selection, element type, grid size, and the boundary conditions, are discussed in detail. Secondly, a method for determination of ultimate bearing capacity is established, which can consider the strength failure. Finally, the effect of load parameters, geometric parameters, and process parameters on the ultimate bearing capacity of joints is analyzed by the global sensitivity analysis method. The results show that the main pipe diameter thickness ratio γ, the main pipe diameter D, and the braided angle α are sensitive to the ultimate bearing capacity N.

Effect of factory effluents on physiological and biochemical contents of Gossypium hirsutum l.

PubMed

Muthusamy, A; Jayabalan, N

2001-10-01

The effect of sago and sugar factory effluents was studied on Gossypium hirsutum L. var. MCU 5 and MCU 11. Plants were irrigated with 0, 25, 50, 75 and 100% of effluents of both factories. At lower concentration (25%) of sugar factory effluents had stimulatory effect on all biochemical contents observed. Moreover, all concentration of sago factory effluents were found to have inhibitory effect on all biochemical contents except proline content which increased with increasing concentration of both the effluents. Plants growing on adjacent to sago and sugar factories or they irrigated with such type of polluted water, may accumulate the heavy metals found in both the effluents, at higher levels in plant products and if consumed may have similar effect on living organisms.

Planning for Multiagent Using ASP-Prolog

NASA Astrophysics Data System (ADS)

Son, Tran Cao; Pontelli, Enrico; Nguyen, Ngoc-Hieu

This paper presents an Answer Set Programming based approach to multiagent planning. The proposed methodology extends the action language \\cal B in [12] to represent and reason about plans with cooperative actions of an individual agent operating in a multiagent environment. This language is used to formalize multiagent planning problems and the notion of a joint plan for multiagent in the presence of cooperative actions. Finally, the paper presents a system for computing joint plans based on the ASP-Prolog system.

Aircraft Fatigue - with Particular Emphasis on Australian Operations and Research.

DTIC Science & Technology

1983-04-01

its research on the fatigue behaviour of full-scale alluminium -alloy structures by undertaking a major investigation using surplus wings from North...on the corrosion fatigue of Taper-Lok bolted joints in D6AC steel. In March 1973 the RAAF finally took delivery of its first F-IliC, and among the...development of multiple defects, corrosion /stress corrosion , detvrirrat- ion of bonded joints, undetected cracks or damage, inadquate repairs 2r untested

Design, fabrication and test of graphite/polymide composite joints and attachments: Summary

NASA Technical Reports Server (NTRS)

Cushman, J. B.; Mccleskey, S. F.; Ward, S. H.

1983-01-01

The design, analysis and testing performed to develop four types of graphite/polyimide (Gr/PI) bonded and bolted composite joints for lightly loaded control surfaces on advanced space transportation systems that operate at temperatures up to 561K (550 F) are summarized. Material properties and 'small specimen' tests were conducted to establish design data and to evaluate specific design details. 'Static discriminator' tests were conducted on preliminary designs to verify structural adequacy. Scaled up specimens of the final joint designs, representative of production size requirements, were subjected to a series of static and fatigue tests to evaluate joint strength. Effects of environmental conditioning were determined by testing aged (125 hours 589K (600 F)) and thermal cycled (116K to 589K (-250 F to 600 F), 125 times) specimens. It is concluded Gr/PI joints can be designed and fabricated to carry the specified loads. Test results also indicate a possible resin loss or degradation of laminates after exposure to 589K (600 F) for 125 hours.

Design, fabrication and test of graphite/polyimide composite joints and attachments. [spacecraft control surfaces

NASA Technical Reports Server (NTRS)

Cushman, J. B.; Mccleskey, S. F.; Ward, S. H.

1982-01-01

The design, analysis, and testing performed to develop four types of graphite/polyimide (Gr/PI) bonded and bolted composite joints for lightly loaded control surfaces on advanced space transportation systems that operate at temperatures up to 561 K (550 F) are summarized. Material properties and small specimen tests were conducted to establish design data and to evaluate specific design details. Static discriminator tests were conducted on preliminary designs to verify structural adequacy. Scaled up specimens of the final joint designs, representative of production size requirements, were subjected to a series of static and fatigue tests to evaluate joint strength. Effects of environmental conditioning were determined by testing aged (125 hours at 589 K (600 F)) and thermal cycled (116 K to 589 K (-250 F to 600 F), 125 times) specimens. It is concluded Gr/PI joints can be designed and fabricated to carry the specified loads. Test results also indicate a possible resin loss or degradation of laminates after exposure to 589 K (600 F) for 125 hours.

Associations between joint attention and language in autism spectrum disorder and typical development: A systematic review and meta-regression analysis.

PubMed

Bottema-Beutel, Kristen

2016-10-01

Using a structured literature search and meta-regression procedures, this study sought to determine whether associations between joint attention and language are moderated by group (autism spectrum disorder [ASD] vs. typical development [TD]), joint attention type (responding to joint attention [RJA] vs. other), and other study design features and participant characteristics. Studies were located using database searches, hand searches, and electronic requests for data from experts in the field. This resulted in 71 reports or datasets and 605 effect sizes, representing 1,859 participants with ASD and 1,835 TD participants. Meta-regression was used to answer research questions regarding potential moderators of the effect sizes of interest, which were Pearson's r values quantifying the association between joint attention and language variables. In the final models, conducted separately for each language variable, effect sizes were significantly higher for the ASD group as compared to the TD group, and for RJA as compared to non-RJA joint attention types. Approximate mental age trended toward significance for the expressive language model. Joint attention may be more tightly tied to language in children with ASD as compared to TD children because TD children exhibit joint attention at sufficient thresholds so that language development becomes untethered to variations in joint attention. Conversely, children with ASD who exhibit deficits in joint attention develop language contingent upon their joint attention abilities. Because RJA was more strongly related to language than other types of joint attention, future research should involve careful consideration of the operationalization and measurement of joint attention constructs. Autism Res 2016, 9: 1021-1035. © 2016 International Society for Autism Research, Wiley Periodicals, Inc. © 2016 International Society for Autism Research, Wiley Periodicals, Inc.

The International Design Study for the Neutrino Factory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Long, K.

2008-02-21

The International Design Study for a future Neutrino Factory and super-beam facility (the ISS) established the physics case for a high-precision programme of long-baseline neutrino-oscillation measurements. The ISS also identified baseline specifications for the Neutrino Factory accelerator complex and the neutrino detector systems. This paper summarises the objectives of the International Design Study for the Neutrino Factory (the IDS-NF). The IDS-NF will build on the work of the ISS to deliver a Reference Design Report for the Neutrino Factory by 2012/13 and an Interim Design Report by 2010/11.

Segmentation of hand radiographs using fast marching methods

NASA Astrophysics Data System (ADS)

Chen, Hong; Novak, Carol L.

2006-03-01

Rheumatoid Arthritis is one of the most common chronic diseases. Joint space width in hand radiographs is evaluated to assess joint damage in order to monitor progression of disease and response to treatment. Manual measurement of joint space width is time-consuming and highly prone to inter- and intra-observer variation. We propose a method for automatic extraction of finger bone boundaries using fast marching methods for quantitative evaluation of joint space width. The proposed algorithm includes two stages: location of hand joints followed by extraction of bone boundaries. By setting the propagation speed of the wave front as a function of image intensity values, the fast marching algorithm extracts the skeleton of the hands, in which each branch corresponds to a finger. The finger joint locations are then determined by using the image gradients along the skeletal branches. In order to extract bone boundaries at joints, the gradient magnitudes are utilized for setting the propagation speed, and the gradient phases are used for discriminating the boundaries of adjacent bones. The bone boundaries are detected by searching for the fastest paths from one side of each joint to the other side. Finally, joint space width is computed based on the extracted upper and lower bone boundaries. The algorithm was evaluated on a test set of 8 two-hand radiographs, including images from healthy patients and from patients suffering from arthritis, gout and psoriasis. Using our method, 97% of 208 joints were accurately located and 89% of 416 bone boundaries were correctly extracted.

Modeling and testing miniature torsion specimens for SiC joining development studies for fusion

DOE PAGES

Henager, Jr., C. H.; Nguyen, Ba N.; Kurtz, Richard J.; ...

2015-08-05

The international fusion community has designed a miniature torsion specimen for neutron irradiation studies of joined SiC and SiC/SiC composite materials. For this research, miniature torsion joints based on this specimen design were fabricated using displacement reactions between Si and TiC to produce Ti 3SiC 2 + SiC joints with SiC and tested in torsion-shear prior to and after neutron irradiation. However, many miniature torsion specimens fail out-of-plane within the SiC specimen body, which makes it problematic to assign a shear strength value to the joints and makes it difficult to compare unirradiated and irradiated strengths to determine irradiation effects.more » Finite element elastic damage and elastic–plastic damage models of miniature torsion joints are developed that indicate shear fracture is more likely to occur within the body of the joined sample and cause out-of-plane failures for miniature torsion specimens when a certain modulus and strength ratio between the joint material and the joined material exists. The model results are compared and discussed with regard to unirradiated and irradiated test data for a variety of joint materials. The unirradiated data includes Ti 3SiC 2 + SiC/CVD-SiC joints with tailored joint moduli, and includes steel/epoxy and CVD-SiC/epoxy joints. Finally, the implications for joint data based on this sample design are discussed.« less

Iowa High School High Tech: Promoting Careers in Technology for Students with Disabilities. Final Report and Implementation Manual.

ERIC Educational Resources Information Center

McQuillen, Terry; Nietupski, John; Berg, Deana Duncan; Daugherty, Vicki; Bildstein, Stephanie

This final report and implementation manual describes the activities and outcomes of Iowa's High School High Tech (HSHT) program, a joint effort of Grant Wood Area Education Agency and Goodwill Industries of Southeast Iowa to inspire students with disabilities to pursue high tech careers. The program provides opportunities for students to learn…

Joint Operations 2030 - Final Report (Operations interarmees 2030 - Rapport final)

DTIC Science & Technology

2011-04-01

case of crisis : • Technologies to support emergency management operations, inter-organisational coordination and communication , distributed...are made up of national representatives as well as generally recognised ‘world class’ scientists. They also provide a communication link to military...Other Entities H.4 Capable of Establishing and Maintaining Communication Channels and Liaison Relationships H-7 with Potential Service Providers

19 CFR Appendix to Part 102 - Textile and Apparel Manufacturer Identification

Code of Federal Regulations, 2011 CFR

2011-04-01

... factories in Macau start with the same words, “Fabrica de Artigos de Vestuario,” which means “Factory of Clothing.” For a factory named “Fabrica de Artigos de Vestuario JUMP HIGH Ltd,” the portion of the factory...; VE20TCEN5880CAR Fabrica de Artigos de Vestuario TOP JOB, Grand River Building, FI 2-4, Macau; MOTOPJOB24MAC THE...

19 CFR Appendix to Part 102 - Textile and Apparel Manufacturer Identification

Code of Federal Regulations, 2010 CFR

2010-04-01

... factories in Macau start with the same words, “Fabrica de Artigos de Vestuario,” which means “Factory of Clothing.” For a factory named “Fabrica de Artigos de Vestuario JUMP HIGH Ltd,” the portion of the factory...; VE20TCEN5880CAR Fabrica de Artigos de Vestuario TOP JOB, Grand River Building, FI 2-4, Macau; MOTOPJOB24MAC THE...

Bulgar Factories (Trading Posts) in the Kama River Area as a Factor of Adjustment to Feudalism

ERIC Educational Resources Information Center

Krylasova, Natalia B.; Belavin, Andrei M.; Podosenova, Yulia A.

2016-01-01

At the start of the 2nd ML AD a number of trading posts, or factories, emerged in the Cis-Ural region with participation of Bulgar handicraftsmen and merchants. They were townships populated by various ethnic groups. Several centuries later similar factories were set up by natives of the Cis-Ural region in Western Siberia. These factories have…

Joining of porous silicon carbide bodies

DOEpatents

Bates, Carl H.; Couhig, John T.; Pelletier, Paul J.

1990-05-01

A method of joining two porous bodies of silicon carbide is disclosed. It entails utilizing an aqueous slip of a similar silicon carbide as was used to form the porous bodies, including the sintering aids, and a binder to initially join the porous bodies together. Then the composite structure is subjected to cold isostatic pressing to form a joint having good handling strength. Then the composite structure is subjected to pressureless sintering to form the final strong bond. Optionally, after the sintering the structure is subjected to hot isostatic pressing to further improve the joint and densify the structure. The result is a composite structure in which the joint is almost indistinguishable from the silicon carbide pieces which it joins.

Joint Services Evaluation Plan for Preferred and Alternate Explosive Fills for Principal Munitions. Joint Services Explosive Fill Program (Long Range) Final Report on the Use of Emergency Funds. Volume 4. Joint Service Safety and Performance Manual for Qualification of Explosives for Military Use

DTIC Science & Technology

1972-09-19

Dextrinated Lead Azide. ŕ.4.2 Reports. Applied Mathematic Panel of the National Defense Research Committee (AMP Report No. t01.1R, SRG-P No. 40). 1-2 0D 44811... dextrinated lead azide. (A normal ranae for these compounds shall have been obtained at the time of testing the explosive to be qualified.) 4.3...normal lead styphnate and dextrinated lead azide obtained using the same apparatus and procedure and run at the same time. 4.3.5 Special Requirements

[Review and prospect of analysis on UHMWPE wear debris in artificial hip joints].

PubMed

Wu, Jingping; Yuan, Chengqing; Yan, Xinping

2010-02-01

This paper briefly reviews the latest progress in the analyses of the technologies for artificial hip joints; and in the researches directed to the features of UHMWPE debris obtained from all kinds of experimental conditions, to the wear process and wear mechanism, and to the factors which influence the wear mechanism. Furthermore, the signification of debris atlas was illustrated. Finally, future directions to be furthered were considered and envisaged. It is suggested that emphases be laid on the relationship between the UHMWPE debris feature and the wear mechanism, and be laid synergistic effects of biochemical environment and loading environment so as to establish the predictive wear models of artificial hip joints.

Cross-view gait recognition using joint Bayesian

NASA Astrophysics Data System (ADS)

Li, Chao; Sun, Shouqian; Chen, Xiaoyu; Min, Xin

2017-07-01

Human gait, as a soft biometric, helps to recognize people by walking. To further improve the recognition performance under cross-view condition, we propose Joint Bayesian to model the view variance. We evaluated our prosed method with the largest population (OULP) dataset which makes our result reliable in a statically way. As a result, we confirmed our proposed method significantly outperformed state-of-the-art approaches for both identification and verification tasks. Finally, sensitivity analysis on the number of training subjects was conducted, we find Joint Bayesian could achieve competitive results even with a small subset of training subjects (100 subjects). For further comparison, experimental results, learning models, and test codes are available.

Analysis of replication factories in human cells by super-resolution light microscopy

PubMed Central

2009-01-01

Background DNA replication in human cells is performed in discrete sub-nuclear locations known as replication foci or factories. These factories form in the nucleus during S phase and are sites of DNA synthesis and high local concentrations of enzymes required for chromatin replication. Why these structures are required, and how they are organised internally has yet to be identified. It has been difficult to analyse the structure of these factories as they are small in size and thus below the resolution limit of the standard confocal microscope. We have used stimulated emission depletion (STED) microscopy, which improves on the resolving power of the confocal microscope, to probe the structure of these factories at sub-diffraction limit resolution. Results Using immunofluorescent imaging of PCNA (proliferating cell nuclear antigen) and RPA (replication protein A) we show that factories are smaller in size (approximately 150 nm diameter), and greater in number (up to 1400 in an early S- phase nucleus), than is determined by confocal imaging. The replication inhibitor hydroxyurea caused an approximately 40% reduction in number and a 30% increase in diameter of replication factories, changes that were not clearly identified by standard confocal imaging. Conclusions These measurements for replication factory size now approach the dimensions suggested by electron microscopy. This agreement between these two methods, that use very different sample preparation and imaging conditions, suggests that we have arrived at a true measurement for the size of these structures. The number of individual factories present in a single nucleus that we measure using this system is greater than has been previously reported. This analysis therefore suggests that each replication factory contains fewer active replication forks than previously envisaged. PMID:20015367

Rapid prototyping 3D virtual world interfaces within a virtual factory environment

NASA Technical Reports Server (NTRS)

Kosta, Charles Paul; Krolak, Patrick D.

1993-01-01

On-going work into user requirements analysis using CLIPS (NASA/JSC) expert systems as an intelligent event simulator has led to research into three-dimensional (3D) interfaces. Previous work involved CLIPS and two-dimensional (2D) models. Integral to this work was the development of the University of Massachusetts Lowell parallel version of CLIPS, called PCLIPS. This allowed us to create both a Software Bus and a group problem-solving environment for expert systems development. By shifting the PCLIPS paradigm to use the VEOS messaging protocol we have merged VEOS (HlTL/Seattle) and CLIPS into a distributed virtual worlds prototyping environment (VCLIPS). VCLIPS uses the VEOS protocol layer to allow multiple experts to cooperate on a single problem. We have begun to look at the control of a virtual factory. In the virtual factory there are actors and objects as found in our Lincoln Logs Factory of the Future project. In this artificial reality architecture there are three VCLIPS entities in action. One entity is responsible for display and user events in the 3D virtual world. Another is responsible for either simulating the virtual factory or communicating with the real factory. The third is a user interface expert. The interface expert maps user input levels, within the current prototype, to control information for the factory. The interface to the virtual factory is based on a camera paradigm. The graphics subsystem generates camera views of the factory on standard X-Window displays. The camera allows for view control and object control. Control or the factory is accomplished by the user reaching into the camera views to perform object interactions. All communication between the separate CLIPS expert systems is done through VEOS.

[Viscosity determination of synovial fluids from the canine hip and elbow joint as well as the human knee joint].

PubMed

Helms, Gabriele; Rittmann, Pia; Wefstaedt, Patrick; Windhagen, Henning; Pressel, Thomas; Behrens, Bernd-Arno; Nolte, Ingo

2008-01-01

The development of pathological changes in both human and canine hip joints is mainly caused by a lack of synovial fluid lubrication. This results in an increased joint abrasion. Even after implantation of joint prosthesis, inadequate lubrication can lead to abrasion in the tribological pair. This can finally result in aseptic loosening of the prosthesis. In spite of the enormous number of studies that have been performed on human, only little knowledge about the tribological properties of the joints in dogs is available in the literature. For this reason the viscosities of synovial fluid, derived from physiological and pathologically changed canine elbow joints were measured. The viscosities were determined by the use of a cone-plate viscometer at different temperatures and shear rates. The obtained values were compared with the viscosity values of pathologically changed synovial fluids from human knee joints as well as with pathological samples from the canine hip joint. The results show that the viscosity values vary within a series of measurements and are inversely proportional to the temperature of the sample and the shear rate. The differences between the average viscosities of canine and human synovial fluids taken from pathologically changed joints are below 4% (22.5 s(-1) at theta1 = 25 degrees C). The findings of this study are being implemented in a FE-Model for the computation of actual forces in the hip joint during different movements. This would represent a contribution to an improved prosthetic treatment of canine and human hips.

Methodological factors affecting joint moments estimation in clinical gait analysis: a systematic review.

PubMed

Camomilla, Valentina; Cereatti, Andrea; Cutti, Andrea Giovanni; Fantozzi, Silvia; Stagni, Rita; Vannozzi, Giuseppe

2017-08-18

Quantitative gait analysis can provide a description of joint kinematics and dynamics, and it is recognized as a clinically useful tool for functional assessment, diagnosis and intervention planning. Clinically interpretable parameters are estimated from quantitative measures (i.e. ground reaction forces, skin marker trajectories, etc.) through biomechanical modelling. In particular, the estimation of joint moments during motion is grounded on several modelling assumptions: (1) body segmental and joint kinematics is derived from the trajectories of markers and by modelling the human body as a kinematic chain; (2) joint resultant (net) loads are, usually, derived from force plate measurements through a model of segmental dynamics. Therefore, both measurement errors and modelling assumptions can affect the results, to an extent that also depends on the characteristics of the motor task analysed (i.e. gait speed). Errors affecting the trajectories of joint centres, the orientation of joint functional axes, the joint angular velocities, the accuracy of inertial parameters and force measurements (concurring to the definition of the dynamic model), can weigh differently in the estimation of clinically interpretable joint moments. Numerous studies addressed all these methodological aspects separately, but a critical analysis of how these aspects may affect the clinical interpretation of joint dynamics is still missing. This article aims at filling this gap through a systematic review of the literature, conducted on Web of Science, Scopus and PubMed. The final objective is hence to provide clear take-home messages to guide laboratories in the estimation of joint moments for the clinical practice.

Dental caries experience in high risk soft drinks factory workers of South India: a comparative study.

PubMed

Kumar, Sandeep; Acharya, Shashidhar; Vasthare, Ramprasad; Singh, Siddharth Kumar; Gupta, Anjali; Debnath, Nitai

2014-01-01

The consumption of soft-drinks has been associated with dental caries development. The aim was to evaluate dental caries experience amongst the workers working in soft-drink industries located in South India and compare it with other factory workers. To evaluate the validity of specific caries index (SCI), which is newer index for caries diagnosis. This was a cross-sectional study carried out among 420 workers (210 in soft-drinks factory and 210 in other factories), in the age group of 20-45 years of Udupi district, Karnataka, India. Index used for clinical examination was decayed, missing, filled surfaces (DMFS) index and SCI. The mean and standard deviation (SD) of decayed surface (5.8 ± 1.8), missing surface (4.3 ± 2) and filled surface (1.94 ± 1.95) and total DMFS score (12.11 ± 3.8) in soft-drinks factory workers were found to be significantly higher than the other factory workers. The total SCI score (mean and SD) was found to be significantly higher in soft-drinks factory workers (5.83 ± 1.80) compared with other factory workers (4.56 ± 1.45). There was a high correlation obtained between SCI score and DMFS score. The regression equation given by DMFS = 1.178 + 1.866 (SCI scores). The caries experience was higher in workers working in soft-drinks factory and this study also showed that specific caries index can be used as a valid index for assessing dental caries experience.

The Role of Spatial Analysis in Detecting the Consequence of the Factory Sites : Case Study of Assalaya Factory-Sudan

NASA Astrophysics Data System (ADS)

Khair, Amar Sharaf Eldin; Purwanto; RyaSunoko, Henna; Abdullah, Omer Adam

2018-02-01

Spatial analysis is considered as one of the most important science for identifying the most appropriate site for industrialization and also to alleviate the environmental ramifications caused by factories. This study aims at analyzing the Assalaya sugarcane factory site by the use of spatial analysis to determine whether it has ramification on the White Nile River. The methodology employed for this study is Global Position System (GPS) to identify the coordinate system of the study phenomena and other relative factors. The study will also make use Geographical Information System (GIS) to implement the spatial analysis. Satellite data (LandsatDem-Digital Elevation Model) will be considered for the study area and factory in identifying the consequences by analyzing the location of the factory through several features such as hydrological, contour line and geological analysis. Data analysis reveals that the factory site is inappropriate and according to observation on the ground it has consequences on the White Nile River. Based on the finding, the study recommended some suggestions to avoid the aftermath of any factory in general. We have to take advantage of this new technological method to aid in selecting most apt locations for industries that will create an ambient environment.

Factorial Experiments: Efficient Tools for Evaluation of Intervention Components

PubMed Central

Collins, Linda M.; Dziak, John J.; Kugler, Kari C.; Trail, Jessica B.

2014-01-01

Background An understanding of the individual and combined effects of a set of intervention components is important for moving the science of preventive medicine interventions forward. This understanding can often be achieved in an efficient and economical way via a factorial experiment, in which two or more independent variables are manipulated. The factorial experiment is a complement to the randomized controlled trial (RCT); the two designs address different research questions. Purpose This article offers an introduction to factorial experiments aimed at investigators trained primarily in the RCT. Method The factorial experiment is compared and contrasted with other experimental designs used commonly in intervention science to highlight where each is most efficient and appropriate. Results Several points are made: factorial experiments make very efficient use of experimental subjects when the data are properly analyzed; a factorial experiment can have excellent statistical power even if it has relatively few subjects per experimental condition; and when conducting research to select components for inclusion in a multicomponent intervention, interactions should be studied rather than avoided. Conclusions Investigators in preventive medicine and related areas should begin considering factorial experiments alongside other approaches. Experimental designs should be chosen from a resource management perspective, which states that the best experimental design is the one that provides the greatest scientific benefit without exceeding available resources. PMID:25092122

Power and color Doppler ultrasound settings for inflammatory flow: impact on scoring of disease activity in patients with rheumatoid arthritis.

PubMed

Torp-Pedersen, Søren; Christensen, Robin; Szkudlarek, Marcin; Ellegaard, Karen; D'Agostino, Maria Antonietta; Iagnocco, Annamaria; Naredo, Esperanza; Balint, Peter; Wakefield, Richard J; Torp-Pedersen, Arendse; Terslev, Lene

2015-02-01

To determine how settings for power and color Doppler ultrasound sensitivity vary on different high- and intermediate-range ultrasound machines and to evaluate the impact of these changes on Doppler scoring of inflamed joints. Six different types of ultrasound machines were used. On each machine, the factory setting for superficial musculoskeletal scanning was used unchanged for both color and power Doppler modalities. The settings were then adjusted for increased Doppler sensitivity, and these settings were designated study settings. Eleven patients with rheumatoid arthritis (RA) with wrist involvement were scanned on the 6 machines, each with 4 settings, generating 264 Doppler images for scoring and color quantification. Doppler sensitivity was measured with a quantitative assessment of Doppler activity: color fraction. Higher color fraction indicated higher sensitivity. Power Doppler was more sensitive on half of the machines, whereas color Doppler was more sensitive on the other half, using both factory settings and study settings. There was an average increase in Doppler sensitivity, despite modality, of 78% when study settings were applied. Over the 6 machines, 2 Doppler modalities, and 2 settings, the grades for each of 7 of the patients varied between 0 and 3, while the grades for each of the other 4 patients varied between 0 and 2. The effect of using different machines, Doppler modalities, and settings has a considerable influence on the quantification of inflammation by ultrasound in RA patients, and this must be taken into account in multicenter studies. Copyright © 2015 by the American College of Rheumatology.

Supernova Dust Factory in M74

NASA Image and Video Library

2006-06-09

Astronomers using NASA Spitzer Space Telescope have spotted a dust factory 30 million light-years away in the spiral galaxy M74. The factory is located at the scene of a massive star explosive death, or supernova.

Maximum in the middle: nonlinear response of microbial plankton to ultraviolet radiation and phosphorus.

PubMed

Medina-Sánchez, Juan Manuel; Delgado-Molina, José Antonio; Bratbak, Gunnar; Bullejos, Francisco José; Villar-Argaiz, Manuel; Carrillo, Presentación

2013-01-01

The responses of heterotrophic microbial food webs (HMFW) to the joint action of abiotic stressors related to global change have been studied in an oligotrophic high-mountain lake. A 2×5 factorial design field experiment performed with large mesocosms for >2 months was used to quantify the dynamics of the entire HMFW (bacteria, heterotrophic nanoflagellates, ciliates, and viruses) after an experimental P-enrichment gradient which approximated or surpassed current atmospheric P pulses in the presence vs. absence of ultraviolet radiation. HMFW underwent a mid-term (<20 days) acute development following a noticeable unimodal response to P enrichment, which peaked at intermediate P-enrichment levels and, unexpectedly, was more accentuated under ultraviolet radiation. However, after depletion of dissolved inorganic P, the HMFW collapsed and was outcompeted by a low-diversity autotrophic compartment, which constrained the development of HMFW and caused a significant loss of functional biodiversity. The dynamics and relationships among variables, and the response patterns found, suggest the importance of biotic interactions (predation/parasitism and competition) in restricting HMFW development, in contrast to the role of abiotic factors as main drivers of autotrophic compartment. The response of HMFW may contribute to ecosystem resilience by favoring the maintenance of the peculiar paths of energy and nutrient-mobilization in these pristine ecosystems, which are vulnerable to threats by the joint action of abiotic stressors related to global change.

An experimental evaluation of patient decision aid design to communicate the effects of medications on the rate of progression of structural joint damage in rheumatoid arthritis.

PubMed

Martin, Richard W; Brower, Matthew E; Geralds, Alexander; Gallagher, Patience J; Tellinghuisen, Donald J

2012-03-01

To explore how effectively information presentation formats used in a patient decision aid communicated the ability of a disease modifying anti-rheumatic drug to slow the rate of progression of rheumatoid arthritis related structural joint damage (SJD). 91 first year psychology students and 91 RA patients participated in a prospective randomized, single blind, factorial experimental design evaluating the effect of four information formats on: satisfaction with risk communication, verbatim and gist recall of a hypothetical anti-rheumatic drug's ability to slow the rate of progression of SJD. Both groups underestimated the hypothetical drug's ability to slow SJD. Formats that supported the narrative statement with a reinforcing graphic element resulted in recall closer to the true value. Comparison of the results from testing of RA patients and college students were remarkably similar across formats. Rate of progression as communicated by narrative statement plus a graphic element (i.e. speedometer metaphor or pictograph) aided recall better than a narrative statement alone. Our results suggest that testing decision aid components with non-patients may provide data generalizable to patient populations. Graphics must be used carefully in patient decision aids as they can enhance recall, but may also introduce unintended recall bias. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Maximum in the Middle: Nonlinear Response of Microbial Plankton to Ultraviolet Radiation and Phosphorus

PubMed Central

Medina-Sánchez, Juan Manuel; Delgado-Molina, José Antonio; Bratbak, Gunnar; Bullejos, Francisco José; Villar-Argaiz, Manuel; Carrillo, Presentación

2013-01-01

The responses of heterotrophic microbial food webs (HMFW) to the joint action of abiotic stressors related to global change have been studied in an oligotrophic high-mountain lake. A 2×5 factorial design field experiment performed with large mesocosms for >2 months was used to quantify the dynamics of the entire HMFW (bacteria, heterotrophic nanoflagellates, ciliates, and viruses) after an experimental P-enrichment gradient which approximated or surpassed current atmospheric P pulses in the presence vs. absence of ultraviolet radiation. HMFW underwent a mid-term (<20 days) acute development following a noticeable unimodal response to P enrichment, which peaked at intermediate P-enrichment levels and, unexpectedly, was more accentuated under ultraviolet radiation. However, after depletion of dissolved inorganic P, the HMFW collapsed and was outcompeted by a low-diversity autotrophic compartment, which constrained the development of HMFW and caused a significant loss of functional biodiversity. The dynamics and relationships among variables, and the response patterns found, suggest the importance of biotic interactions (predation/parasitism and competition) in restricting HMFW development, in contrast to the role of abiotic factors as main drivers of autotrophic compartment. The response of HMFW may contribute to ecosystem resilience by favoring the maintenance of the peculiar paths of energy and nutrient-mobilization in these pristine ecosystems, which are vulnerable to threats by the joint action of abiotic stressors related to global change. PMID:23593178

Baby Factories in Nigeria: Starting the Discussion Toward a National Prevention Policy.

PubMed

Makinde, Olusesan Ayodeji; Olaleye, Olalekan; Makinde, Olufunmbi Olukemi; Huntley, Svetlana S; Brown, Brandon

2017-01-01

Baby factories and baby harvesting are relatively new terms that involve breeding, trafficking, and abuse of infants and their biological mothers. Since it was first described in a United Nations Educational, Scientific and Cultural Organization report in Nigeria in 2006, several more baby factories have been discovered over the years. Infertile women are noted to be major patrons of these baby factories due to the stigmatization of childless couples in Southern Nigeria and issues around cultural acceptability of surrogacy and adoption. These practices have contributed to the growth in the industry which results in physical, psychological, and sexual violence to the victims. Tackling baby factories will involve a multifaceted approach that includes advocacy and enacting of legislation barring baby factories and infant trafficking and harsh consequences for their patrons. Also, programs to educate young girls on preventing unwanted pregnancies are needed. Methods of improving awareness and acceptability of adoption and surrogacy and reducing the administrative and legal bottlenecks associated with these options for infertile couples should be explored to diminish the importance of baby factories. © The Author(s) 2015.

A practical limit to trials needed in one-person randomized controlled experiments.

PubMed

Alemi, Roshan; Alemi, Farrokh

2007-01-01

Recently in this journal, J. Olsson and colleagues suggested the use of factorial experimental designs to guide a patient's efforts to choose among multiple interventions. These authors argue that factorial design, where every possible combination of the interventions is tried, is superior to sequential trial and errors. Factorial design is efficient in identifying the effectiveness of interventions (factor effect). Most patients care only about feeling better and not why their conditions are improving. If the goal of the patient is to get better and not to estimate the factor effect, then no control groups are needed. In this article, we show a modification in the factorial design of experiments proposed by Olsson and colleagues where a full-factorial design is planned, but experimentation is stopped when the patient's condition improves. With this modification, the number of trials is radically fewer than those needed by factorial design. For example, a patient trying out 4 different interventions with a median probability of success of .50 is expected to need 2 trials before stopping the experimentation in comparison with 32 in a full-factorial design.

[Risk assessment and countermeasures of BTEX contamination in soils of typical pesticide factory].

PubMed

Tan, Bing; Wang, Tie-Yu; Li, Qi-Feng; Zhang, Hai-Yan; Pang, Bo; Zhu, Zhao-Yun; Wang, Dao-Han; Lü, Yong-Long

2014-06-01

Soil samples around three representative pesticide factories were collected in Zhangjiakou City, Hebei Province, and analyzed to identify their pollution characteristics and health risk of BTEX by purge-and trap and gas chromatography/mass spectroscopy method. Total concentrations of BTEX in soils in Plant A, B and C ranged from 673.50 to 32 363.50 ng x g(-1), nd to 6 461.80 ng x g(-1) and 461.70 to 8 740.80 ng x g(-1), respectively. Concentrations of detected toluene (4 619.50-7 234.30 ng x g(-1)) and ethylbenzene (364.60-7 944.60 ng x g(-1)) had exceeded the Canadian guidelines for industrial land (370 ng x g(-1) and 82 ng x g(-1)), and concentration of xylene (19 799.40 ng x g(-1)) in dust in production area of Plant A was larger than the Dutch soil intervention value (17 000 ng x g(-1)). While concentrationsn of BTEX around Plant A (Region I ) and Plant B and C (Region II) ranged from nd to 645.81 ng x g(-1), and nd to 309.13 ng x g(-1), respectively, which were below the Canadian guidelines for agricultural land. The non-carcinogenic risk of BTEX in Plant A (2.90E-06 -1.32E-04), B (nd -4.30E-05) and C (1.29E-06 -5.64E-05) were all below 1, which suggested that no obvious health risk existed in each plant. The non-carcinogenic risks in Region I (nd -2.02E-06) and Region II (nd -1.10E-06) were below than 1, and also lower than those in factories. High risk areas were mainly concentrated in the downwind, moreover, soils around villages and towns were also with higher risk. In conclusion, soils and dusts in each factory had been polluted and the quality of agricultural land had been partly deteriorated. Finally, environmental management and occupational protection countermeasures were proposed based on the research results.

The EB Factory: Fundamental Stellar Astrophysics with Eclipsing Binary Stars Discovered by Kepler

NASA Astrophysics Data System (ADS)

Stassun, Keivan

Eclipsing binaries (EBs) are key laboratories for determining the fundamental properties of stars. EBs are therefore foundational objects for constraining stellar evolution models, which in turn are central to determinations of stellar mass functions, of exoplanet properties, and many other areas. The primary goal of this proposal is to mine the Kepler mission light curves for: (1) EBs that include a subgiant star, from which precise ages can be derived and which can thus serve as critically needed age benchmarks; and within these, (2) long-period EBs that include low-mass M stars or brown dwarfs, which are increa-singly becoming the focus of exoplanet searches, but for which there are the fewest available fundamental mass- radius-age benchmarks. A secondary goal of this proposal is to develop an end-to-end computational pipeline -- the Kepler EB Factory -- that allows automatic processing of Kepler light curves for EBs, from period finding, to object classification, to determination of EB physical properties for the most scientifically interesting EBs, and finally to accurate modeling of these EBs for detailed tests and benchmarking of theoretical stellar evolution models. We will integrate the most successful algorithms into a single, cohesive workflow environment, and apply this 'Kepler EB Factory' to the full public Kepler dataset to find and characterize new "benchmark grade" EBs, and will disseminate both the enhanced data products from this pipeline and the pipeline itself to the broader NASA science community. The proposed work responds directly to two of the defined Research Areas of the NASA Astrophysics Data Analysis Program (ADAP), specifically Research Area #2 (Stellar Astrophysics) and Research Area #9 (Astrophysical Databases). To be clear, our primary goal is the fundamental stellar astrophysics that will be enabled by the discovery and analysis of relatively rare, benchmark-grade EBs in the Kepler dataset. At the same time, to enable this goal will require bringing a suite of extant and new custom algorithms to bear on the Kepler data, and thus our development of the Kepler EB Factory represents a value-added product that will allow the widest scientific impact of the in-formation locked within the vast reservoir of the Kepler light curves.

Building America Industrialized Housing Partnership (BAIHP)

DOE Office of Scientific and Technical Information (OSTI.GOV)

McIlvaine, Janet; Chandra, Subrato; Barkaszi, Stephen

This final report summarizes the work conducted by the Building America Industrialized Housing Partnership (www.baihp.org) for the period 9/1/99-6/30/06. BAIHP is led by the Florida Solar Energy Center of the University of Central Florida and focuses on factory built housing. In partnership with over 50 factory and site builders, work was performed in two main areas--research and technical assistance. In the research area--through site visits in over 75 problem homes, we discovered the prime causes of moisture problems in some manufactured homes and our industry partners adopted our solutions to nearly eliminate this vexing problem. Through testing conducted in overmore » two dozen housing factories of six factory builders we documented the value of leak free duct design and construction which was embraced by our industry partners and implemented in all the thousands of homes they built. Through laboratory test facilities and measurements in real homes we documented the merits of 'cool roof' technologies and developed an innovative night sky radiative cooling concept currently being tested. We patented an energy efficient condenser fan design, documented energy efficient home retrofit strategies after hurricane damage, developed improved specifications for federal procurement for future temporary housing, compared the Building America benchmark to HERS Index and IECC 2006, developed a toolkit for improving the accuracy and speed of benchmark calculations, monitored the field performance of over a dozen prototype homes and initiated research on the effectiveness of occupancy feedback in reducing household energy use. In the technical assistance area we provided systems engineering analysis, conducted training, testing and commissioning that have resulted in over 128,000 factory built and over 5,000 site built homes which are saving their owners over $17,000,000 annually in energy bills. These include homes built by Palm Harbor Homes, Fleetwood, Southern Energy Homes, Cavalier and the manufacturers participating in the Northwest Energy Efficient Manufactured Home program. We worked with over two dozen Habitat for Humanity affiliates and helped them build over 700 Energy Star or near Energy Star homes. We have provided technical assistance to several show homes constructed for the International builders show in Orlando, FL and assisted with other prototype homes in cold climates that save 40% over the benchmark reference. In the Gainesville Fl area we have several builders that are consistently producing 15 to 30 homes per month in several subdivisions that meet the 30% benchmark savings goal. We have contributed to the 2006 DOE Joule goals by providing two community case studies meeting the 30% benchmark goal in marine climates.« less

Final Environmental Assessment: Central Issue Facility at Joint Base McGuire-Dix-Lakehurst, New Jersey

DTIC Science & Technology

2013-05-01

commercial and retail services to the military personnel on the Joint Base and the civilian population. The unemployment rate in New Hanover Township...Division of Banking and Insurance, the annual number of foreclosures in Burlington County increased steadily from 1,312 in 2005 to a high of 3,391 in...2009 (NJ Division of Banking , 2011). However, this annual figure represents only 1.9 percent of the total housing units in the County (US Census

Extended Task Space Control for Robotic Manipulators

NASA Technical Reports Server (NTRS)

Backes, Paul G. (Inventor); Long, Mark K. (Inventor)

1996-01-01

The invention is a method of operating a robot in successive sampling intervals to perform a task, the robot having joints and joint actuators with actuator control loops, by decomposing the task into behavior forces, accelerations, velocities and positions of plural behaviors to be exhibited by the robot simultaneously, computing actuator accelerations of the joint actuators for the current sampling interval from both behavior forces, accelerations velocities and positions of the current sampling interval and actuator velocities and positions of the previous sampling interval, computing actuator velocities and positions of the joint actuators for the current sampling interval from the actuator velocities and positions of the previous sampling interval, and, finally, controlling the actuators in accordance with the actuator accelerations, velocities and positions of the current sampling interval. The actuator accelerations, velocities and positions of the current sampling interval are stored for use during the next sampling interval.

Dynamic coupling of underactuated manipulators

NASA Astrophysics Data System (ADS)

Bergerman, Marcel; Lee, Christopher; Xu, Yangsheng

1994-08-01

In recent years, researchers have been turning their attention to so called underactuated systems, where the term underactuated refers to the fact that the system has more joints than control actuators. Some examples of underactuated systems are robot manipulators with failed actuators; free-floating space robots, where the base can be considered as a virtual passive linkage in inertia space; legged robots with passive joints; hyper-redundant (snake-like) robots with passive joints, etc. From the examples above, it is possible to justify the importance of the study of underactuated systems. For example, if some actuators of a conventional manipulator fail, the loss of one or more degrees of freedom may compromise an entire operation. In free-floating space systems, the base (satellite) can be considered as a 6-DOF device without positioning actuators. Finally, manipulators with passive joints and hyper-redundant robots with few actuators are important from the viewpoint of energy saving, lightweight design and compactness.

Selection of test paths for solder joint intermittent connection faults under DC stimulus

NASA Astrophysics Data System (ADS)

Huakang, Li; Kehong, Lv; Jing, Qiu; Guanjun, Liu; Bailiang, Chen

2018-06-01

The test path of solder joint intermittent connection faults under direct-current stimulus is examined in this paper. According to the physical structure of the circuit, a network model is established first. A network node is utilised to represent the test node. The path edge refers to the number of intermittent connection faults in the path. Then, the selection criteria of the test path based on the node degree index are proposed and the solder joint intermittent connection faults are covered using fewer test paths. Finally, three circuits are selected to verify the method. To test if the intermittent fault is covered by the test paths, the intermittent fault is simulated by a switch. The results show that the proposed method can detect the solder joint intermittent connection fault using fewer test paths. Additionally, the number of detection steps is greatly reduced without compromising fault coverage.

1. GENERAL VIEW OF COMPLEX, SHOWING FACTORY BUILDING IN LEFT ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. GENERAL VIEW OF COMPLEX, SHOWING FACTORY BUILDING IN LEFT FOREGROUND, GRINDING PLATFORM AT REAR OF FACTORY, AND STABLE AREA AND OVERSEER'S HOUSE TO RIGHT - Caneel Bay Plantation, General Views, Cruz Bay, St. John, VI

Survey of Nitrate Ion Concentrations in Vegetables Cultivated in Plant Factories: Comparison with Open-Culture Vegetables.

PubMed

Oka, Yuka; Hirayama, Izumi; Yoshikawa, Mitsuhide; Yokoyama, Tomoko; Iida, Kenji; Iwakoshi, Katsushi; Suzuki, Ayana; Yanagihara, Midori; Segawa, Yukino; Kukimoto, Sonomi; Hamada, Humika; Matsuzawa, Satomi; Tabata, Setsuko; Sasamoto, Takeo

2017-01-01

A survey of nitrate-ion concentrations in plant-factory-cultured leafy vegetables was conducted. 344 samples of twenty-one varieties of raw leafy vegetables were examined using HPLC. The nitrate-ion concentrations in plant-factory-cultured leafy vegetables were found to be LOD-6,800 mg/kg. Furthermore, the average concentration values varied among different leafy vegetables. The average values for plant-factory-cultured leafy vegetables were higher than those of open-cultured leafy vegetables reported in previous studies, such as the values listed in the Standard Tables of Food Composition in Japan- 2015 - (Seventh revised edition). For some plant-factory-cultured leafy vegetables, such as salad spinach, the average values were above the maximum permissible levels of nitrate concentration in EC No 1258/2011; however, even when these plant-factory-cultured vegetables were routinely eaten, the intake of nitrate ions in humans did not exceed the ADI.

30 CFR 18.61 - Final inspection of complete machine.

Code of Federal Regulations, 2011 CFR

2011-07-01

... substantially modified design of a previously approved one shall be inspected by a qualified representative(s... requirements of this part with respect to joints, lead entrances, and other pertinent features. (2) Wiring...

Watertight pipe joint survey : final report

DOT National Transportation Integrated Search

2000-04-01

Oregon Department of Transportation (ODOT) has been specifying watertight pipes for storm sewer and some culvert pipe installations. The ODOT designer is responsible for specifying the watertight requirement, but there is no currently accepted standa...

Joint Planning and Development Office Work Plan FY10

DTIC Science & Technology

2010-01-01

IPSA ) Division will make refinements to the NextGen Portfolio Analysis. In addition, IPSA will work with the Department of Defense (DoD) to define and...Submitted Interagency Portfolio and Systems Analysis ( IPSA ) DRAFT DoD Portfolio Analysis Criteria BASELINE DoD Portfolio Analysis Criteria DRAFT...WG Work Plan Review Prototype Capability Selected and Defined CHAs Complete Safety Metrics for IPSA Complete FINAL Prototype Report FINAL

Automatic control of positioning along the joint during EBW in conditions of action of magnetic fields

NASA Astrophysics Data System (ADS)

Druzhinina, A. A.; Laptenok, V. D.; Murygin, A. V.; Laptenok, P. V.

2016-11-01

Positioning along the joint during the electron beam welding is a difficult scientific and technical problem to achieve the high quality of welds. The final solution of this problem is not found. This is caused by weak interference protection of sensors of the joint position directly in the welding process. Frequently during the electron beam welding magnetic fields deflect the electron beam from the optical axis of the electron beam gun. The collimated X-ray sensor is used to monitor the beam deflection caused by the action of magnetic fields. Signal of X-ray sensor is processed by the method of synchronous detection. Analysis of spectral characteristics of the X-ray sensor showed that the displacement of the joint from the optical axis of the gun affects on the output signal of sensor. The authors propose dual-circuit system for automatic positioning of the electron beam on the joint during the electron beam welding in conditions of action of magnetic interference. This system includes a contour of joint tracking and contour of compensation of magnetic fields. The proposed system is stable. Calculation of dynamic error of system showed that error of positioning does not exceed permissible deviation of the electron beam from the joint plane.

Stress analysis of bolted joints under centrifugal force

NASA Astrophysics Data System (ADS)

Imura, Makoto; Iizuka, Motonobu; Nakae, Shigeki; Mori, Takeshi; Koyama, Takayuki

2014-06-01

Our objective is to develop a long-life rotary machine for synchronous generators and motors. To do this, it is necessary to design a high-strength bolted joint, which is responsible for fixing a salient pole on a rotor shaft. While the rotary machine is in operation, not only centrifugal force but also moment are loaded on a bolted joint, because a point of load is eccentric to a centre of a bolt. We tried to apply the theory proposed in VDI2230-Blatt1 to evaluate the bolted joint under eccentric force, estimate limited centrifugal force, which is the cause of partial separation between the pole and the rotor shaft, and then evaluate additional tension of a bolt after the partial separation has occurred. We analyzed the bolted joint by FEM, and defined load introduction factor in that case. Additionally, we investigated the effect of the variation of bolt preload on the partial separation. We did a full scale experiment with a prototype rotor to reveal the variation of bolt preload against tightening torque. After that, we verified limited centrifugal force and the strength of the bolted joint by the VDI2230-Blatt1 theory and FEM considering the variation of bolt preload. Finally, we could design a high-strength bolted joint verified by the theoretical study and FEM analysis.

Arthroscopic procedures and therapeutic results of anatomical reconstruction of the coracoclavicular ligaments for acromioclavicular Joint dislocation.

PubMed

Takase, K; Yamamoto, K

2016-09-01

Surgical treatment is recommended for type 5 acromioclavicular joint dislocation on Rockwood's classification. We believe that anatomic repair of the coracoclavicular ligaments best restores the function of the acromioclavicular joint. We attempted to correctly reconstruct the anatomy of the coracoclavicular ligaments under arthroscopy, and describe the minimally invasive arthroscopic procedure. There were 22 patients; mean age at surgery, 38.1 years. Mean time to surgery was 13.2 days. Mean follow-up was 3 years 2 months. The palmaris longus tendon was excised from the ipsilateral side to replace the conoid ligament, while artificial ligament was used for reconstructing the trapezoid ligament. Both ligament reconstructions were performed arthroscopically. No temporary fixation of the acromioclavicular joint was performed. On postoperative radiographic evaluation, 4 patients showed subluxation and 2 showed dislocation of the acromioclavicular joint; the other 16 patients had maintained reduction at the final consultation. MR images 1year after surgery clearly revealed the reconstructed ligaments in 19 patients. Only 1 patient showed osteoarthritis of the acromioclavicular joint. Although it requires resection of the ipsilateral palmaris longus for grafting, we believe that anatomic reconstruction of both coracoclavicular ligaments best restores the function of the acromioclavicular joint. 4. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

Staged lengthening arthroplasty for pediatric osteosarcoma around the knee.

PubMed

Kong, Chang-Bae; Lee, Soo-Yong; Jeon, Dae-Geun

2010-06-01

Orthopaedic oncologists often must address leg-length discrepancy after resection of tumors in growing patients with osteosarcoma. There are various alternatives to address this problem. We describe a three-stage procedure: (1) temporary arthrodesis, (2) lengthening by Ilizarov apparatus, and (3) tumor prosthesis. We asked (1) to what extent are affected limbs actually lengthened; (2) how many of the patients who undergo a lengthening procedure eventually achieve joint arthroplasty; and (3) can the three-stage procedure give patients a functioning joint with equalization of limb length? We reviewed 56 patients (younger than 14 years) with osteosarcoma who had staged lengthening arthroplasty between 1991 and 2004. Thirty-five of the 56 patients (63%) underwent soft tissue lengthening, and of these 35, 28 (50% of the original group of 56) had implantation of a mobile joint. Three of the 28 prostheses were later removed owing to infection after arthroplasty. The overall average length gained was 7.8 cm (range, 4-14 cm), and 25 (71%) of the 35 patients had a mobile joint at final followup. The average Musculoskeletal Tumor Society functional score was 23.2 (range, 15-28) and limb-length discrepancy at final followup was 2.6 cm (range, 0-6.5 cm). Although most mobile joints had an acceptable ROM (average, 74.2 degrees ; range, 35 degrees -110 degrees ), extension lag was frequent. Our approach is one option for skeletally immature patients, especially in situations where an expandable prosthesis is not available. However, this technique requires multiple stages and would be inappropriate for patients who cannot accept prolonged functional deficit owing to a limited lifespan or other reasons. Level IV, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.

Improving the Ability of Mathematic Representation Capabilities and Students Skills in Importing Square Forms to Square Using Variation Solutions

NASA Astrophysics Data System (ADS)

Nirawati, R.

2018-04-01

This research was conducted to see whether the variation of the solution is acceptable and easy to understand by students with different level of ability so that it can be seen the difference of students ability in facilitating the quadratic form in the upper, middle and lower groups. This research used experimental method with factorial design. Based on the result of final test analysis, there were differences of students ability in upper group, medium group, and lower group in putting squared form based on the use certain variation of solution.

Expression in Escherichia coli, refolding and crystallization of Aspergillus niger feruloyl esterase A using a serial factorial approach.

PubMed

Benoit, Isabelle; Coutard, Bruno; Oubelaid, Rachid; Asther, Marcel; Bignon, Christophe

2007-09-01

Hydrolysis of plant biomass is achieved by the combined action of enzymes secreted by microorganisms and directed against the backbone and the side chains of plant cell wall polysaccharides. Among side chains degrading enzymes, the feruloyl esterase A (FAEA) specifically removes feruloyl residues. Thus, FAEA has potential applications in a wide range of industrial processes such as paper bleaching or bio-ethanol production. To gain insight into FAEA hydrolysis activity, we solved its crystal structure. In this paper, we report how the use of four consecutive factorial approaches (two incomplete factorials, one sparse matrix, and one full factorial) allowed expressing in Escherichia coli, refolding and then crystallizing Aspergillus niger FAEA in 6 weeks. Culture conditions providing the highest expression level were determined using an incomplete factorial approach made of 12 combinations of four E. coli strains, three culture media and three temperatures (full factorial: 36 combinations). Aspergillus niger FAEA was expressed in the form of inclusion bodies. These were dissolved using a chaotropic agent, and the protein was purified by affinity chromatography on Ni column under denaturing conditions. A suitable buffer for refolding the protein eluted from the Ni column was found using a second incomplete factorial approach made of 96 buffers (full factorial: 3840 combinations). After refolding, the enzyme was further purified by gel filtration, and then crystallized following a standard protocol: initial crystallization conditions were found using commercial crystallization screens based on a sparse matrix. Crystals were then optimized using a full factorial screen.

Joint inversion of apparent resistivity and seismic surface and body wave data

NASA Astrophysics Data System (ADS)

Garofalo, Flora; Sauvin, Guillaume; Valentina Socco, Laura; Lecomte, Isabelle

2013-04-01

A novel inversion algorithm has been implemented to jointly invert apparent resistivity curves from vertical electric soundings, surface wave dispersion curves, and P-wave travel times. The algorithm works in the case of laterally varying layered sites. Surface wave dispersion curves and P-wave travel times can be extracted from the same seismic dataset and apparent resistivity curves can be obtained from continuous vertical electric sounding acquisition. The inversion scheme is based on a series of local 1D layered models whose unknown parameters are thickness h, S-wave velocity Vs, P-wave velocity Vp, and Resistivity R of each layer. 1D models are linked to surface-wave dispersion curves and apparent resistivity curves through classical 1D forward modelling, while a 2D model is created by interpolating the 1D models and is linked to refracted P-wave hodograms. A priori information can be included in the inversion and a spatial regularization is introduced as a set of constraints between model parameters of adjacent models and layers. Both a priori information and regularization are weighted by covariance matrixes. We show the comparison of individual inversions and joint inversion for a synthetic dataset that presents smooth lateral variations. Performing individual inversions, the poor sensitivity to some model parameters leads to estimation errors up to 62.5 %, whereas for joint inversion the cooperation of different techniques reduces most of the model estimation errors below 5% with few exceptions up to 39 %, with an overall improvement. Even though the final model retrieved by joint inversion is internally consistent and more reliable, the analysis of the results evidences unacceptable values of Vp/Vs ratio for some layers, thus providing negative Poisson's ratio values. To further improve the inversion performances, an additional constraint is added imposing Poisson's ratio in the range 0-0.5. The final results are globally improved by the introduction of this constraint further reducing the maximum error to 30 %. The same test was performed on field data acquired in a landslide-prone area close by the town of Hvittingfoss, Norway. Seismic data were recorded on two 160-m long profiles in roll-along mode using a 5-kg sledgehammer as source and 24 4.5-Hz vertical geophones with 4-m separation. First-arrival travel times were picked at every shot locations and surface wave dispersion curves extracted at 8 locations for each profile. 2D resistivity measurements were carried out on the same profiles using Gradient and Dipole-Dipole arrays with 2-m electrode spacing. The apparent resistivity curves were extracted at the same location as for the dispersion curves. The data were subsequently jointly inverted and the resulting model compared to individual inversions. Although models from both, individual and joint inversions are consistent, the estimation error is smaller for joint inversion, and more especially for first-arrival travel times. The joint inversion exploits different sensitivities of the methods to model parameters and therefore mitigates solution nonuniqueness and the effects of intrinsic limitations of the different techniques. Moreover, it produces an internally consistent multi-parametric final model that can be profitably interpreted to provide a better understanding of subsurface properties.

Muon Acceleration Concepts for NuMAX: "Dual-use" Linac and "Dogbone" RLA

DOE PAGES

Bogacz, S. A.

2018-02-01

In this paper, we summarize the current state of a concept for muon acceleration aimed at a future Neutrino Factory. The main thrust of these studies was to reduce the overall cost while maintaining performance by exploring the interplay between the complexity of the cooling systems and the acceptance of the accelerator complex. To ensure adequate survival for the short-lived muons, acceleration must occur at high average gradient. The need for large transverse and longitudinal acceptances drives the design of the acceleration system to an initially low RF frequency, e.g., 325 MHz, which is then increased to 650 MHz asmore » the transverse size shrinks with increasing energy. High-gradient normal conducting RF cavities at these frequencies require extremely high peak-power RF sources. Hence superconducting RF (SRF) cavities are chosen. Finally, we consider two cost effective schemes for accelerating muon beams for a stageable Neutrino Factory: exploration of the so-called "dual-use" linac concept, where the same linac structure is used for acceleration of both H - and muons and, alternatively, an SRF-efficient design based on a multi-pass (4.5) "dogbone" RLA, extendable to multi-pass FFAG-like arcs.« less

Formulation optimization of gentamicin loaded Eudragit RS100 microspheres using factorial design study.

PubMed

Singh, Deependra; Saraf, Swarnlata; Dixit, Vinod Kumar; Saraf, Shailendra

2008-04-01

Gentamicin-Eudragit RS100 microspheres were prepared by modified double emulsion method. A 3(2) full factorial experiment was designed to study the effects of the composition of outer aqueous phase in terms of amount of glycerol (viscosity effect) and sodium chloride (osmotic pressure gradient effect) on the entrapment efficiency and % yield and microsphere size. The results of analysis of variance test for responses measured indicated that the test is significant (p>0.05). The contribution of sodium chloride concentration was found to be higher on entrapment efficiency and % yield, whereas glycerol produced significant effect on the mean diameter of microspheres. Microspheres demonstrated spherical particles in the size range of 33.24-60.43 microm. In vitro release profile of optimized formulation demonstrated sustained release for 24 h following Higuchi kinetics. Finally, drug bioactivity was found to remain intact after microencapsulation. Response surface graphs are presented to examine the effects of independent variables on the responses studied. Thus, by formulation design important parameters affecting formulation characteristics of gentamicin loaded Eudragit RS100 microspheres can be identified for controlled delivery with desirable characters in terms of maximum entrapment and yield.

60-MW test using the 30-MW klystrons for the KEKB project

NASA Astrophysics Data System (ADS)

Fukuda, S.; Michizono, S.; Nakao, K.; Saito, Y.; Anami, S.

1995-07-01

The B-Factory is a future plan, requiring an energy upgrade of the KEK linac from 2.5 GeV to 8.0 GeV (KEKB Project). This paper describes the recent development of an S-band high-power pulse klystron to be used as the PF-linac rf-source of the B-Factory. This tube is a modified version of the existing 30-MW tube, which produces 51 MW at a 310 kV beam voltage by optimizing the focusing magnetic field. In order to increase the reliability, the cathode diameter, the gun housing, and the insulation ceramic-seal were enlarged. This tube was redesigned so as to have the same characteristics as the test results of 30-MW tubes at a higher applied voltage without changing the rf interaction region. Four prototype tubes have been manufactured; final test results showed that these new tubes produce an output power of more than 50 MW at 310 kV with an efficiency of 46%. Recently this tube has produced more than 60 MW at a 350 kV beam voltage for a demonstration test. A comparison between the FCI-code prediction and the test results is also given in this paper.

Advanced continuous cultivation methods for systems microbiology.

PubMed

Adamberg, Kaarel; Valgepea, Kaspar; Vilu, Raivo

2015-09-01

Increasing the throughput of systems biology-based experimental characterization of in silico-designed strains has great potential for accelerating the development of cell factories. For this, analysis of metabolism in the steady state is essential as only this enables the unequivocal definition of the physiological state of cells, which is needed for the complete description and in silico reconstruction of their phenotypes. In this review, we show that for a systems microbiology approach, high-resolution characterization of metabolism in the steady state--growth space analysis (GSA)--can be achieved by using advanced continuous cultivation methods termed changestats. In changestats, an environmental parameter is continuously changed at a constant rate within one experiment whilst maintaining cells in the physiological steady state similar to chemostats. This increases the resolution and throughput of GSA compared with chemostats, and, moreover, enables following of the dynamics of metabolism and detection of metabolic switch-points and optimal growth conditions. We also describe the concept, challenge and necessary criteria of the systematic analysis of steady-state metabolism. Finally, we propose that such systematic characterization of the steady-state growth space of cells using changestats has value not only for fundamental studies of metabolism, but also for systems biology-based metabolic engineering of cell factories.

Microencapsulation of Theobroma cacao L. waste extract: optimization using response surface methodology.

PubMed

Gabbay Alves, Taís Vanessa; Silva da Costa, Russany; Aliakbarian, Bahar; Casazza, Alessandro Alberto; Perego, Patrizia; Carréra Silva Júnior, José Otávio; Ribeiro Costa, Roseane Maria; Converti, Attilio

2017-03-01

The cocoa extract (Theobroma cacao L.) has a significant amount of polyphenols (TP) with potent antioxidant activity (AA). This study aims to optimise microencapsulation of the extract of cocoa waste using chitosan and maltodextrin. Microencapsulation tests were performed according to a Box-Behnken factorial design, and the results were evaluated by response surface methodology with temperature, maltodextrin concentration (MD) and extract flowrate (EF) as independent variables, and the fraction of encapsulated TP, TP encapsulation yield, AA, yield of drying and solubility index as responses. The optimum conditions were: inlet temperature of 170 °C, MD of 5% and EF of 2.5 mL/min. HPLC analysis identified epicatechin as the major component of both the extract and microparticles. TP release was faster at pH 3.5 than in water. These results as a whole suggest that microencapsulation was successful and the final product can be used as a nutrient source for aquatic animal feed. Highlights Microencapsulation is optimised according to a factorial design of the Box-Behnken type. Epicatechin is the major component of both the extract and microcapsules. The release of polyphenols from microcapsules is faster at pH 3.5 than in water.

Kazakhstan In situ BioTransformation of Mercury ...

EPA Pesticide Factsheets

Our final international work on the biological decontamination of the mercury contamination of soils in the Northern outskirts of Pavlodar as a result of activity at the former PO “Khimprom” chemical plant is reported here. The plant produced chlorine and alkali from the 1970s into the 1990s using the electrolytic amalgam method entailing the use of massive amounts of mercury. Ground water became contaminated with Hg resulting in a plume 470 m wide, 1.9 km long, estimated to contain 2 million cubic meters of water. This plume could reach the River Irtysh, a source of drinking water for large cities in Kazakhstan and Russia. Significant amounts of mercuric compounds are deposited in the sediments of Lake Balkyldak, 1.5 km north of the factory. This lake occasionally received wastewater from the factory. Phase I of the PO “Kimprom” clean-up that isolated the major sources of mercury at the site was completed in 2004. However, significant amounts of mercury remain underground including groundwater contaminated with Hg in the form of HgCl2 with little to no elemental or methyl mercury (MeHg). Develop biotechnology strategies to mitigate mercury contamination in groundwater

Psychometric examination and factorial validity of the Exercise Dependence Scale-Revised in Italian exercisers.

PubMed

Costa, Sebastiano; Cuzzocrea, Francesca; Hausenblas, Heather A; Larcan, Rosalba; Oliva, Patrizia

2012-12-01

Background and aims The purpose of this study was to verify the factorial structure, internal validity, reliability, and criterion validity of the 21-item Exercise Dependence Scale-Revised (EDS-R) in an Italian sample. Methods Italian voluntary (N = 519) users of gyms who had a history of regular exercise for over a year completed the EDS-R and measures of exercise frequency. Results and conclusions Confirmatory factor analyses demonstrated a good fit to the hypothesized 7-factor model, and adequate internal consistency for the scale was evidenced. Criterion validity was evidenced by significant correlations among all the subscale of the EDS and exercise frequency. Finally, individuals at risk for exercise dependence reported more exercise behavior compared to the nondependent-symptomatic and nondependent-asymptomatic groups. These results suggest that the seven subscales of the Italian version of the EDS are measuring the construct of exercise dependence as defined by the DSM-IV criteria for substance dependence and also confirm previous research using the EDS-R in other languages. More research is needed to examine the psychometric properties of the EDS-R in diverse populations with various research designs.

Investigation on the Cracking Character of Jointed Rock Mass Beneath TBM Disc Cutter

NASA Astrophysics Data System (ADS)

Yang, Haiqing; Liu, Junfeng; Liu, Bolong

2018-04-01

With the purpose to investigate the influence of joint dip angle and spacing on the TBM rock-breaking efficacy and cracking behaviour, experiments that include miniature cutter head tests are carried out on sandstone rock material. In the experiment, prefabricated joints of different forms are made in rock samples. Then theoretical analysis is conducted to improve the calculating models of the fractured work and crack length of rock in the TBM process. The experimental results indicate that lower rupture angles appear for specimens with joint dip angles between 45° and 60°. Meanwhile, rock-breaking efficacy for rock mass with joint dip angles in this interval is also higher. Besides, the fracture patterns are transformed from compressive shear mode to tensile shear mode as the joint spacing decreases. As a result, failure in a greater extent is resulted for specimens with smaller joint spacings. The results above suggest that joint dip angle between 45° and 60° and joint spacing of 1 cm are the optimal rock-breaking conditions for the tested specimens. Combining the present experimental data and taking the joint dip angle and spacing into consideration, the calculating model for rock fractured work that proposed by previous scholars is improved. Finally, theoretical solution of rock median and side crack length is also derived based on the analytical method of elastoplastic invasion fracture for indenter. The result of the analytical solution is also in good agreement with the actual measured experimental result. The present study may provide some primary knowledge about the rock cracking character and breaking efficacy under different engineering conditions.

Joint Smoothed l₀-Norm DOA Estimation Algorithm for Multiple Measurement Vectors in MIMO Radar.

PubMed

Liu, Jing; Zhou, Weidong; Juwono, Filbert H

2017-05-08

Direction-of-arrival (DOA) estimation is usually confronted with a multiple measurement vector (MMV) case. In this paper, a novel fast sparse DOA estimation algorithm, named the joint smoothed l 0 -norm algorithm, is proposed for multiple measurement vectors in multiple-input multiple-output (MIMO) radar. To eliminate the white or colored Gaussian noises, the new method first obtains a low-complexity high-order cumulants based data matrix. Then, the proposed algorithm designs a joint smoothed function tailored for the MMV case, based on which joint smoothed l 0 -norm sparse representation framework is constructed. Finally, for the MMV-based joint smoothed function, the corresponding gradient-based sparse signal reconstruction is designed, thus the DOA estimation can be achieved. The proposed method is a fast sparse representation algorithm, which can solve the MMV problem and perform well for both white and colored Gaussian noises. The proposed joint algorithm is about two orders of magnitude faster than the l 1 -norm minimization based methods, such as l 1 -SVD (singular value decomposition), RV (real-valued) l 1 -SVD and RV l 1 -SRACV (sparse representation array covariance vectors), and achieves better DOA estimation performance.

Rapidly growing non-tuberculous mycobacteria infection of prosthetic knee joints: A report of two cases.

PubMed

Kim, Manyoung; Ha, Chul-Won; Jang, Jae Won; Park, Yong-Beom

2017-08-01

Non-tuberculous mycobacteria (NTM) cause prosthetic knee joint infections in rare cases. Infections with rapidly growing non-tuberculous mycobacteria (RGNTM) are difficult to treat due to their aggressive clinical behavior and resistance to antibiotics. Infections of a prosthetic knee joint by RGNTM have rarely been reported. A standard of treatment has not yet been established because of the rarity of the condition. In previous reports, diagnoses of RGNTM infections in prosthetic knee joints took a long time to reach because the condition was not suspected, due to its rarity. In addition, it is difficult to identify RGNTM in the lab because special identification tests are needed. In previous reports, after treatment for RGNTM prosthetic infections, knee prostheses could not be re-implanted in all cases but one, resulting in arthrodesis or resection arthroplasty; this was most likely due to the aggressiveness of these organisms. In the present report, two cases of prosthetic knee joint infection caused by RGNTM (Mycobacterium abscessus) are described that were successfully treated, and in which prosthetic joints were finally reimplanted in two-stage revision surgery. Copyright © 2017 Elsevier B.V. All rights reserved.

Integrating PCLIPS into ULowell's Lincoln Logs: Factory of the future

NASA Technical Reports Server (NTRS)

Mcgee, Brenda J.; Miller, Mark D.; Krolak, Patrick; Barr, Stanley J.

1990-01-01

We are attempting to show how independent but cooperating expert systems, executing within a parallel production system (PCLIPS), can operate and control a completely automated, fault tolerant prototype of a factory of the future (The Lincoln Logs Factory of the Future). The factory consists of a CAD system for designing the Lincoln Log Houses, two workcells, and a materials handling system. A workcell consists of two robots, part feeders, and a frame mounted vision system.

Human platelet lysate in mesenchymal stromal cell expansion according to a GMP grade protocol: a cell factory experience.

PubMed

Becherucci, Valentina; Piccini, Luisa; Casamassima, Serena; Bisin, Silvia; Gori, Valentina; Gentile, Francesca; Ceccantini, Riccardo; De Rienzo, Elena; Bindi, Barbara; Pavan, Paola; Cunial, Vanessa; Allegro, Elisa; Ermini, Stefano; Brugnolo, Francesca; Astori, Giuseppe; Bambi, Franco

2018-05-02

The use of platelet lysate (PL) for the ex-vivo expansion of mesenchymal stromal/stem cells (MSCs) was initially proposed by Doucet et al. in 2005, as an alternative to animal serum. Moreover, regulatory authorities discourage the use of fetal bovine serum (FBS) or other animal derivatives, to avoid risk of zoonoses and xenogeneic immune reactions. Even if many studies investigated PL composition, there still are some open issues related to its use in ex-vivo MSC expansion, especially according to good manufacturing practice (GMP) grade protocols. As an authorized cell factory, we report our experience using standardized PL produced by Azienda Ospedaliero Universitaria Meyer Transfusion Service for MSC expansion according to a GMP grade clinical protocol. As suggested by other authors, we performed an in-vitro test on MSCs versus MSCs cultured with FBS that still represents the best way to test PL batches. We compared 12 MSC batches cultured with DMEM 5% PL with similar batches cultured with DMEM 10% FBS, focusing on the MSC proliferation rate, MSC surface marker expression, MSC immunomodulatory and differentiation potential, and finally MSC relative telomere length. Results confirmed the literature data as PL increases cell proliferation without affecting the MSC immunophenotype, immunomodulatory potential, differentiation potential and relative telomere length. PL can be considered a safe alternative to FBS for ex-vivo expansion of MSC according to a GMP grade protocol. Our experience confirms the literature data: a large number of MSCs for clinical applications can be obtained by expansion with PL, without affecting the MSC main features. Our experience underlines the benefits of a close collaboration between the PL producers (transfusion service) and the end users (cell factory) in a synergy of skills and experiences that can lead to standardized PL production.

Suitability of a three-dimensional model to measure empathy and its relationship with social and normative adjustment in Spanish adolescents: a cross-sectional study.

PubMed

Herrera-López, Mauricio; Gómez-Ortiz, Olga; Ortega-Ruiz, Rosario; Jolliffe, Darrick; Romera, Eva M

2017-09-25

(1) To examine the psychometric properties of the Basic Empathy Scale (BES) with Spanish adolescents, comparing a two and a three-dimensional structure;(2) To analyse the relationship between the three-dimensional empathy and social and normative adjustment in school. Transversal and ex post facto retrospective study. Confirmatory factorial analysis, multifactorial invariance analysis and structural equations models were used. 747 students (51.3% girls) from Cordoba, Spain, aged 12-17 years (M=13.8; SD=1.21). The original two-dimensional structure was confirmed (cognitive empathy, affective empathy), but a three-dimensional structure showed better psychometric properties, highlighting the good fit found in confirmatory factorial analysis and adequate internal consistent valued, measured with Cronbach's alpha and McDonald's omega. Composite reliability and average variance extracted showed better indices for a three-factor model. The research also showed evidence of measurement invariance across gender. All the factors of the final three-dimensional BES model were direct and significantly associated with social and normative adjustment, being most strongly related to cognitive empathy. This research supports the advances in neuroscience, developmental psychology and psychopathology through a three-dimensional version of the BES, which represents an improvement in the original two-factorial model. The organisation of empathy in three factors benefits the understanding of social and normative adjustment in adolescents, in which emotional disengagement favours adjusted peer relationships. Psychoeducational interventions aimed at improving the quality of social life in schools should target these components of empathy. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Factorial experimental design for the culture of human embryonic stem cells as aggregates in stirred suspension bioreactors reveals the potential for interaction effects between bioprocess parameters.

PubMed

Hunt, Megan M; Meng, Guoliang; Rancourt, Derrick E; Gates, Ian D; Kallos, Michael S

2014-01-01

Traditional optimization of culture parameters for the large-scale culture of human embryonic stem cells (ESCs) as aggregates is carried out in a stepwise manner whereby the effect of varying each culture parameter is investigated individually. However, as evidenced by the wide range of published protocols and culture performance indicators (growth rates, pluripotency marker expression, etc.), there is a lack of systematic investigation into the true effect of varying culture parameters especially with respect to potential interactions between culture variables. Here we describe the design and execution of a two-parameter, three-level (3(2)) factorial experiment resulting in nine conditions that were run in duplicate 125-mL stirred suspension bioreactors. The two parameters investigated here were inoculation density and agitation rate, which are easily controlled, but currently, poorly characterized. Cell readouts analyzed included fold expansion, maximum density, and exponential growth rate. Our results reveal that the choice of best case culture parameters was dependent on which cell property was chosen as the primary output variable. Subsequent statistical analyses via two-way analysis of variance indicated significant interaction effects between inoculation density and agitation rate specifically in the case of exponential growth rates. Results indicate that stepwise optimization has the potential to miss out on the true optimal case. In addition, choosing an optimum condition for a culture output of interest from the factorial design yielded similar results when repeated with the same cell line indicating reproducibility. We finally validated that human ESCs remain pluripotent in suspension culture as aggregates under our optimal conditions and maintain their differentiation capabilities as well as a stable karyotype and strong expression levels of specific human ESC markers over several passages in suspension bioreactors.

Optimization of the Ion Source-Mass Spectrometry Parameters in Non-Steroidal Anti-Inflammatory and Analgesic Pharmaceuticals Analysis by a Design of Experiments Approach.

PubMed

Paíga, Paula; Silva, Luís M S; Delerue-Matos, Cristina

2016-10-01

The flow rates of drying and nebulizing gas, heat block and desolvation line temperatures and interface voltage are potential electrospray ionization parameters as they may enhance sensitivity of the mass spectrometer. The conditions that give higher sensitivity of 13 pharmaceuticals were explored. First, Plackett-Burman design was implemented to screen significant factors, and it was concluded that interface voltage and nebulizing gas flow were the only factors that influence the intensity signal for all pharmaceuticals. This fractionated factorial design was projected to set a full 2(2) factorial design with center points. The lack-of-fit test proved to be significant. Then, a central composite face-centered design was conducted. Finally, a stepwise multiple linear regression and subsequently an optimization problem solving were carried out. Two main drug clusters were found concerning the signal intensities of all runs of the augmented factorial design. p-Aminophenol, salicylic acid, and nimesulide constitute one cluster as a result of showing much higher sensitivity than the remaining drugs. The other cluster is more homogeneous with some sub-clusters comprising one pharmaceutical and its respective metabolite. It was observed that instrumental signal increased when both significant factors increased with maximum signal occurring when both codified factors are set at level +1. It was also found that, for most of the pharmaceuticals, interface voltage influences the intensity of the instrument more than the nebulizing gas flowrate. The only exceptions refer to nimesulide where the relative importance of the factors is reversed and still salicylic acid where both factors equally influence the instrumental signal. Graphical Abstract ᅟ.

Avian reovirus microNS protein forms homo-oligomeric inclusions in a microtubule-independent fashion, which involves specific regions of its C-terminal domain.

PubMed

Brandariz-Nuñez, Alberto; Menaya-Vargas, Rebeca; Benavente, Javier; Martinez-Costas, Jose

2010-05-01

Members of the genus Orthoreovirus replicate in cytoplasmic inclusions termed viral factories. Compelling evidence suggests that the nonstructural protein microNS forms the matrix of the factories and recruits specific viral proteins to these structures. In the first part of this study, we analyzed the properties of avian reovirus factories and microNS-derived inclusions and found that they are nonaggresome cytoplasmic globular structures not associated with the cytoskeleton which do not require an intact microtubule network for formation and maturation. We next investigated the capacity of avian reovirus microNS to form inclusions in transfected and baculovirus-infected cells. Our results showed that microNS is the main component of the inclusions formed by recombinant baculovirus expression. This, and the fact that microNS is able to self-associate inside the cell, suggests that microNS monomers contain all the interacting domains required for inclusion formation. Examination of the inclusion-forming capacities of truncated microNS versions allowed us to identify the region spanning residues 448 to 635 of microNS as the smallest that was inclusion competent, although residues within the region 140 to 380 seem to be involved in inclusion maturation. Finally, we investigated the roles that four different motifs present in microNS(448-635) play in inclusion formation, and the results suggest that the C-terminal tail domain is a key determinant in dictating the initial orientation of monomer-to-monomer contacts to form basal oligomers that control inclusion shape and inclusion-forming efficiency. Our results contribute to an understanding of the generation of structured protein aggregates that escape the cellular mechanisms of protein recycling.

Developing the STS sound pollution unit for enhancing students' applying knowledge among science technology engineering and mathematics

NASA Astrophysics Data System (ADS)

Jumpatong, Sutthaya; Yuenyong, Chokchai

2018-01-01

STEM education suggested that students should be enhanced to learn science with integration between Science, Technology, Engineering and Mathematics. To help Thai students make sense of relationship between Science, Technology, Engineering and Mathematics, this paper presents learning activities of STS Sound Pollution. The developing of STS Sound Pollution is a part of research that aimed to enhance students' perception of the relationship between Science Technology Engineering and Mathematics. This paper will discuss how to develop Sound Pollution through STS approach in framework of Yuenyong (2006) where learning activities were provided based on 5 stages. These included (1) identification of social issues, (2) identification of potential solutions, (3) need for knowledge, (4) decisionmaking, and (5) socialization stage. The learning activities could be highlighted as following. First stage, we use video clip of `Problem of people about Sound Pollution'. Second stage, students will need to identification of potential solutions by design Home/Factory without noisy. The need of scientific and other knowledge will be proposed for various alternative solutions. Third stage, students will gain their scientific knowledge through laboratory and demonstration of sound wave. Fourth stage, students have to make decision for the best solution of designing safety Home/Factory based on their scientific knowledge and others (e.g. mathematics, economics, art, value, and so on). Finally, students will present and share their Design Safety Home/Factory in society (e.g. social media or exhibition) in order to validate their ideas and redesigning. The paper, then, will discuss how those activities would allow students' applying knowledge of science technology engineering, mathematics and others (art, culture and value) for their possible solution of the STS issues.

Field isotopic study of lead fate and compartmentalization in earthworm-soil-metal particle systems for highly polluted soil near Pb recycling factory.

PubMed

Goix, Sylvaine; Mombo, Stéphane; Schreck, Eva; Pierart, Antoine; Lévêque, Thibaut; Deola, Frédéric; Dumat, Camille

2015-11-01

Earthworms are important organisms in soil macrofauna and play a key role in soil functionality, and consequently in terrestrial ecotoxicological risk assessments. Because they are frequently observed in soils strongly polluted by metals, the influence of earthworm bioturbation on Pb fate could therefore be studied through the use of Pb isotopes. Total Pb concentrations and isotopic composition ((206)Pb, (207)Pb and (208)Pb) were then measured in earthworms, casts and bulk soils sampled at different distance from a lead recycling factory. Results showed decreasing Pb concentrations with the distance from the factory whatever the considered matrix (bulk soils, earthworm bodies or cast samples) with higher concentrations in bulk soils than in cast samples. The bivariate plot (208)Pb/(206)Pb ratios versus (206)Pb/(207)Pb ratios showed that all samples can be considered as a linear mixing between metallic process particulate matter (PM) and geochemical Pb background. Calculated anthropogenic fraction of Pb varied between approximately 84% and 100%. Based on Pb isotopic signatures, the comparison between casts, earthworms and bulk soils allowed to conclude that earthworms preferentially ingest the anthropogenic lead fraction associated with coarse soil organic matter. Actually, soil organic matter was better correlated with Pb isotopic ratios than with Pb content in soils. The proposed hypothesis is therefore a decrease of soil organic matter turnover due to Pb pollution with consequences on Pb distribution in soils and earthworm exposure. Finally, Pb isotopes analysis constitutes an efficient tool to study the influence of earthworm bioturbation on Pb cycle in polluted soils. Copyright © 2015 Elsevier Ltd. All rights reserved.

Environmental impact of cheese production: A case study of a small-scale factory in southern Europe and global overview of carbon footprint.

PubMed

Canellada, Fernando; Laca, Amanda; Laca, Adriana; Díaz, Mario

2018-09-01

The environmental performance of a small-scale cheese factory sited in a NW Spanish region has been analysed by Life Cycle Assessment (LCA) as representative of numerous cheese traditional factories that are scattered through the European Union, especially in the southern countries. Inventory data were directly obtained from this facility corresponding to one-year operation, and the main subsystems involved in cheese production were included, i.e. raw materials, water, electricity, energy, cleaning products, packaging materials, transports, solid and liquid wastes and gas emissions. Results indicated that the environmental impacts derived from cheese making were mainly originated from raw milk production and the natural land transformation was the most affected of the considered categories. On the contrary, the manufacturing of packaging material and other non-dairy ingredients barely influenced on the total impact. Additionally, an average carbon footprint of the cheeses produced in the analysed facility has also been calculated, resulting milk production and pellet boiler emissions the most contributing subsystems. Furthermore, it was notable the positive environmental effect that entailed the direct use of whey as animal feed, which was considered in this study as avoided fodder. Finally, a revision of published works regarding the environmental performance of cheese production worldwide was provided and compared to results found in the present work. According to the analysed data, it is clear that the content of fat and dry extract are determinant factors for the carbon footprint of cheeses, whereas the cheesemaking scale and the geographical area have a very low effect. Copyright © 2018. Published by Elsevier B.V.

Factorial experiments: efficient tools for evaluation of intervention components.

PubMed

Collins, Linda M; Dziak, John J; Kugler, Kari C; Trail, Jessica B

2014-10-01

An understanding of the individual and combined effects of a set of intervention components is important for moving the science of preventive medicine interventions forward. This understanding can often be achieved in an efficient and economical way via a factorial experiment, in which two or more independent variables are manipulated. The factorial experiment is a complement to the RCT; the two designs address different research questions. To offer an introduction to factorial experiments aimed at investigators trained primarily in the RCT. The factorial experiment is compared and contrasted with other experimental designs used commonly in intervention science to highlight where each is most efficient and appropriate. Several points are made: factorial experiments make very efficient use of experimental subjects when the data are properly analyzed; a factorial experiment can have excellent statistical power even if it has relatively few subjects per experimental condition; and when conducting research to select components for inclusion in a multicomponent intervention, interactions should be studied rather than avoided. Investigators in preventive medicine and related areas should begin considering factorial experiments alongside other approaches. Experimental designs should be chosen from a resource management perspective, which states that the best experimental design is the one that provides the greatest scientific benefit without exceeding available resources. Copyright © 2014 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.

Flaw Tolerance in Lap Shear Brazed Joints. Part 1

NASA Technical Reports Server (NTRS)

Flom, Yury; Wang, Li-Qin

2003-01-01

Furnace brazing is a joining process used in the aerospace and other industries to produce strong permanent and hermetic structural joints. As in any joining process, brazed joints have various imperfections and defects. At the present time, our understanding of the influence of the internal defects on the strength of the brazed joints is not adequate. The goal of this 3-part investigation is to better understand the properties and failure mechanisms of the brazed joints containing defects. This study focuses on the behavior of the brazed lap shear joints because of their importance in manufacturing aerospace structures. In Part 1, an average shear strength capability and failure modes of the single lap joints are explored. Stainless steel specimens brazed with pure silver are tested in accordance with the AWS C3.2 standard. Comparison of the failure loads and the ultimate shear strength with the Finite Element Analysis (FEA) of the same specimens as a function of the overlap widths shows excellent correlation between the experimental and calculated values for the defect-free lap joints. A damage zone criterion is shown to work quite well in understanding the failure of the braze joints. In Part 2, the findings of the Part 1 will be verified on the larger test specimens. Also, various flaws will be introduced in the test specimens to simulate lack of braze coverage in the lap joints. Mechanical testing and FEA will be performed on these joints to verify that behavior of the flawed ductile lap joints is similar to joints with a reduced braze area. Finally, in Part 3, the results obtained in Parts 1 and 2 will be applied to the actual brazed structure to evaluate the load-carrying capability of a structural lap joint containing discontinuities. In addition, a simplified engineering procedure will be offered for the laboratory testing of the lap shear specimens.

Influence of age on the outcome of single stage reconstructive surgery for congenital dislocation of the hip joint.

PubMed

Bhatti, Anisuddin; Jamali, A R; Mehboob, Ghulam

2009-01-01

This study was conducted to assess the effect of age on the ultimate outcome measures following single stage surgical procedure of soft tissue release, relocation, capsulorrhaphy, femoral shortening with varus/derotation osteotomy and pelvic osteotomy. A case series. The study with two groups of pretest-posttest design was conducted at Department of Orthopaedic Surgery, Jinnah Postgraduate Medical Centre (JPMC), Karachi, from 1993 to January 2008. Patients included were having neglected, congenital dislocation of the hip joint, aged over 3 years. Patients with failed previous surgery, paralytic, teratological, traumatic or septic dislocations and patients with less than 5 years follow-up were excluded from the study. The patients were divided into two groups, 3-7 years (37 hip joints) and over 7 years (13 hip joints). The single stage surgical procedure of open relocation, femoral shortening/derotation/ varus osteotomy and pelvic osteotomy was the dependent variable; whereas, the final clinico-radiological results based upon Tonnis grading, Severin's clinical/radiological grading, Klisic's overall rating and acetabular index were the independent variables of the study. Pre- and postoperative data was assessed for overall improvement and the difference in outcome measures between the two age groups. Significant overall improvement on all parameters was achieved after surgery. When results were compared between two age groups, there was no significant difference in the final outcome as per Tonnis grading and Severin's clinical typing as modified by Gibson (97.3% versus 84.4% normal hip joints or Tonnis grade 1 and 78.37% versus 53.85% Severin's type 1) but the results based upon Severin's radiological grading (62.16% versus 15.38%) and Klisic's overall rating (62.16% versus 15.38%) were significantly better in 3-7 years as compared to those over 7 years. There was no significant difference between the two age groups when compared for improvement in acetabular index. On further analysis, a progressive deterioration of results with increasing age was observed, yet the results in those aged over 7 years were reasonably justified surgical correction of congenital dislocation of the hip joint. Majority of the complications were seen in children operated at the age of 4-5 years. There were 7 cases (14%) of redislocation/subluxation and 6 were in 3-7 years age group. There were 4 cases (8%) of the avascular necrosis of the femoral head. Three patients had residual coxa vara and 2 had significant limb shortening. Limb lengthening was done in these 2 cases. The final results displayed progressive deterioration of clinical, radiological and functional outcome measures with aging after single stage reconstructive surgery for the congenital dislocation of hip joint. However, despite this, the results in children over 7 years were also good/excellent in most of the cases justifying surgery.

Technology and Participation in Japanese Factories: The Consequences for Morale and Productivity.

ERIC Educational Resources Information Center

Hull, Frank; Azumi, Koya

1988-01-01

By fully using their human resources, Japanese factories mass produce goods of low cost and high quality. Participation in Japanese factories occurs in a more hierarchical framework than advocated in the Western model of worker democracy. (JOW)

Do you really represent my task? Sequential adaptation effects to unexpected events support referential coding for the joint Simon effect.

PubMed

Klempova, Bibiana; Liepelt, Roman

2016-07-01

Recent findings suggest that a Simon effect (SE) can be induced in Individual go/nogo tasks when responding next to an event-producing object salient enough to provide a reference for the spatial coding of one's own action. However, there is skepticism against referential coding for the joint Simon effect (JSE) by proponents of task co-representation. In the present study, we tested assumptions of task co-representation and referential coding by introducing unexpected double response events in a joint go/nogo and a joint independent go/nogo task. In Experiment 1b, we tested if task representations are functionally similar in joint and standard Simon tasks. In Experiment 2, we tested sequential updating of task co-representation after unexpected single response events in the joint independent go/nogo task. Results showed increased JSEs following unexpected events in the joint go/nogo and joint independent go/nogo task (Experiment 1a). While the former finding is in line with the assumptions made by both accounts (task co-representation and referential coding), the latter finding supports referential coding. In contrast to Experiment 1a, we found a decreased SE after unexpected events in the standard Simon task (Experiment 1b), providing evidence against the functional equivalence assumption between joint and two-choice Simon tasks of the task co-representation account. Finally, we found an increased JSE also following unexpected single response events (Experiment 2), ruling out that the findings of the joint independent go/nogo task in Experiment 1a were due to a re-conceptualization of the task situation. In conclusion, our findings support referential coding also for the joint Simon effect.

The effect of postprocessing on tensile property and microstructure evolution of friction stir welding aluminum alloy joint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hu, Z.L., E-mail: zhilihuhit@163.com; State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Harbin 150001; State Key Laboratory of Materials Processing and Die & Mould Technology, Huazhong University of Science and Technology

Friction stir welding is an efficient manufacturing method for joining aluminum alloy and can dramatically reduce grain size conferring excellent plastic deformation properties. Consequently, friction stir welding is used to manufacture tailor welded blanks to optimize weight or performance in the final component. In the study, the microstructural evolution and mechanical properties of friction stir welding joint during plastic forming and subsequent heat treatment were investigated. The microstructural characteristics of the friction stir welding joints were studied by Electron Backscattered Diffraction and Transmission Electron Microscopy. The mechanical properties were evaluated by tensile and microhardness tests. It is found that themore » tensile and yield strengths of friction stir welding joints are significantly improved after severe plastic deformation due to the grain refinement. Following heat treatment, the strength of the friction stir welding joints significantly decrease due to the obvious abnormal grain growth. Careful attention must be given to the processing route of any friction stir welding joint intended for plastic forming, especially the annealing between forming passes. Severe plastic deforming of the friction stir welding joint leads to a high level of stored energy/dislocation density, which causes the abnormal grain growth during subsequent heat treatment, and consequently reduce the mechanical properties of the friction stir welding joint. - Highlights: • Great changes are observed in the microstructure of FSW joint after postprocessing. • Postprocessing shows great effect on the microstructure stability of FSW joint. • The weld shows more significant decrease in strength than the BM due to the AGG. • Attention must be given to the processing route of FSW joint for plastic forming.« less

Tracing the contamination origin of coliform bacteria in two small food-processing factories.

PubMed

Tominaga, Tatsuya; Sekine, Masahiro; Oyaizu, Hiroshi

2008-09-01

The objective of this study was to trace contamination sources of coliform bacteria by comparing the types of coliforms between food samples and the processing environments in two small food-processing factories (factories A and B). Fermentation tests of five sugars enabled the successful classification of 16 representative type strains into eight distinct groups. The grouping procedure was then applied to comparison of the coliform flora between food products and various locations in their processing environments. The consistency between each food and the tested locations was evaluated using the Jaccard index. The air conditioner and refrigeration room floor in factory A showed an index of 1.00, while the shaping machine in factory B showed an index of 0.98, indicating that these locations could be contamination sources. The validity of our results was confirmed by randomly amplified polymorphic DNA, which showed 100% matched profiles between the air conditioner and the food in factory A, and highly matched profiles between the machine and the food in factory B. This method for comparing the coliform flora between food and environments has the potential to be a reliable tracing tool for various food industries.

SWITCH: a dynamic CRISPR tool for genome engineering and metabolic pathway control for cell factory construction in Saccharomyces cerevisiae.

PubMed

Vanegas, Katherina García; Lehka, Beata Joanna; Mortensen, Uffe Hasbro

2017-02-08

The yeast Saccharomyces cerevisiae is increasingly used as a cell factory. However, cell factory construction time is a major obstacle towards using yeast for bio-production. Hence, tools to speed up cell factory construction are desirable. In this study, we have developed a new Cas9/dCas9 based system, SWITCH, which allows Saccharomyces cerevisiae strains to iteratively alternate between a genetic engineering state and a pathway control state. Since Cas9 induced recombination events are crucial for SWITCH efficiency, we first developed a technique TAPE, which we have successfully used to address protospacer efficiency. As proof of concept of the use of SWITCH in cell factory construction, we have exploited the genetic engineering state of a SWITCH strain to insert the five genes necessary for naringenin production. Next, the naringenin cell factory was switched to the pathway control state where production was optimized by downregulating an essential gene TSC13, hence, reducing formation of a byproduct. We have successfully integrated two CRISPR tools, one for genetic engineering and one for pathway control, into one system and successfully used it for cell factory construction.

1. FACTORY BUILDING VIEWED FROM THE EAST, CURING AND STORAGE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. FACTORY BUILDING VIEWED FROM THE EAST, CURING AND STORAGE WING TO THE LEFT, BOILING HOUSE IN THE CENTER, GRINDING PLATFORM TO THE FAR RIGHT, ST. THOMAS ISLAND VISIBLE IN BACKGROUND - Caneel Bay Plantation, Sugar Factory, Cruz Bay, St. John, VI

Autocrine and/or paracrine insulin-like growth factor-I activity in skeletal muscle

NASA Technical Reports Server (NTRS)

Adams, Gregory R.

2002-01-01

Similar to bone, skeletal muscle responds and adapts to changes in loading state via mechanisms that appear to be intrinsic to the muscle. One of the mechanisms modulating skeletal muscle adaptation it thought to involve the autocrine and/or paracrine production of insulinlike growth factor-I. This brief review outlines components of the insulinlike growth factor-I system as it relates to skeletal muscle and provides the rationale for the theory that insulinlike growth factor-I is involved with muscle adaptation.

Asymptotic Normality Through Factorial Cumulants and Partition Identities

PubMed Central

Bobecka, Konstancja; Hitczenko, Paweł; López-Blázquez, Fernando; Rempała, Grzegorz; Wesołowski, Jacek

2013-01-01

In the paper we develop an approach to asymptotic normality through factorial cumulants. Factorial cumulants arise in the same manner from factorial moments as do (ordinary) cumulants from (ordinary) moments. Another tool we exploit is a new identity for ‘moments’ of partitions of numbers. The general limiting result is then used to (re-)derive asymptotic normality for several models including classical discrete distributions, occupancy problems in some generalized allocation schemes and two models related to negative multinomial distribution. PMID:24591773

Fluid flow analysis of E-glass fiber reinforced pipe joints in oil and gas industry

NASA Astrophysics Data System (ADS)

Bobba, Sujith; Leman, Z.; Zainuddin, E. S.; Sapuan, S. M.

2018-04-01

Glass Fiber reinforced composites have become increasingly important over the past few years and now they are the first choice materials for fabricating pipes with low weight in combination with high strength and stiffness. In Oil And Gas Industry, The Pipelines transporting heavy crude oil are subjected to variable pressure waves causing fluctuating stress levels in the pipes. Computational Fluid Dynamics (CFD) analysis was performed using solid works flow stimulation software to study the effects of these pressure waves on some specified joints in the pipes. Depending on the type of heavy crude oil being used, the flow behavior indicated a considerable degree of stress levels in certain connecting joints, causing the joints to become weak over a prolonged period of use. This research proposes a new perspective that is still required to be developed regarding the change of the pipe material, fiber winding angle in those specified joints and finally implementing cad wind technology to check the output result of the stress levels so that the life of the pipes can be optimized.

Rehabilitation in children with juvenile chronic arthritis.

PubMed

Häfner, R; Truckenbrodt, H; Spamer, M

1998-05-01

Chronic childhood arthritis impairs joint function and may result in severe physical handicap. Joint pain and inflammation trigger a vicious cycle that often ends in joint damage and fixed deformities. A comprehensive rehabilitation programme must start early to restore loss of function and prevent permanent handicap. It is dominated by a physiotherapeutic regimen consisting of pain relief, movement expansion, training of muscular coordination and finally re-integration of a physiological movement pattern. The approaches of occupational therapy become integrated into the treatment programme, concentrating on joint protection and self-care training. Additional aids support the aim of joint restoration. They include individual splinting, adapted footwear and walking aids. Depending on the child's age and developmental status different aspects of rehabilitation dominate. Small children need adequate mobility to promote their psychosocial development. In later years integration into school life and the peer group becomes important. Adolescents require help for an adequate vocational training and self-care support. Last but not least, parental education and integration of the whole family into the rehabilitation programme markedly improve the patient's prognosis.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cai, Yunhai

Similar to a super B-factory, a circular Higgs factory will require strong focusing systems near the interaction points and a low-emittance lattice in arcs to achieve a factory luminosity. At electron beam energy of 120 GeV, beamstrahlung effects during the collision pose an additional challenge to the collider design. In particular, a large momentum acceptance at 2 percent level is necessary to retain an adequate beam lifetime. This turns out to be the most challenging aspect in the design of circular Higgs factory. In this paper, an example will be provided to illustrate the beam dynamics in circular Higgs factory,more » emphasizing on the chromatic optics. Basic optical modules and advanced analysis will be presented. Most important, we will show that 2% momentum aperture is achievable« less

Determination of oleamide and erucamide in polyethylene films by pressurised fluid extraction and gas chromatography.

PubMed

Garrido-López, Alvaro; Esquiu, Vanesa; Tena, María Teresa

2006-08-18

A pressurized fluid extraction (PFE) and gas chromatography-flame ionization detection (GC-FID) method is proposed to determine the slip agents in polyethylene (PE) films. The study of PFE variables was performed using a fractional factorial design (FFD) for screening and a central composite design (CCD) for optimizing the main variables obtained from the Pareto charts. The variables that were studied include temperature, static time, percentage of cyclohexane and the number of extraction cycles. The final condition selected was pure isopropanol (two times) at 105 degrees C for 16min. The recovery of spiked oleamide and erucamide was around 100%. The repeatability of the method was between 9.6% for oleamide and 8% for erucamide, expressed as relative standard deviation. Finally, the method was applied to determine oleamide and erucamide in several polyethylene films and the results were statistically equal to those obtained by pyrolysis and gas-phase chemiluminescence (CL).

Planing Meeting on Asian/Pacific Joint Production Programme of Materials for Neo-Literates in Rural Areas (Tokyo, Japan, June 7-9, 1993). Report.

ERIC Educational Resources Information Center

Asia/Pacific Cultural Centre for UNESCO, Tokyo (Japan).

This publication provides the final report of a planning meeting to discuss literacy programs of the Asia/Pacific Cultural Center for UNESCO (ACCU) to be carried out under regional cooperation and other materials from the meeting. The final report describes the purpose of the meeting and summarizes these presentations: opening addresses, reports,…

OPERATION CASTLE. Radiological Safety. Volume 1

DTIC Science & Technology

1985-09-01

OPERATION CASTLE Radiological Safety Final Report Volume I Headquarters Joint Task Force Seven Technical Branch, J-3 Division Washington, DC...Spring 1954 EXTRACTED VERSION DTIC -uECTE MAR031986 NOTICE: This is an extract of Operation CASTLE, Radiological Safety, Final Report, Volume I ...SYMBOL (If jpQiictbl») ■ i PROCUREMENT INSTRUMENT IDENTIFICATION NUMBER 8c AOORESS (G(y, SU(t tncl ZIRCod») 10 SOURCE OF FUNDING NUMBERS PROGRAM

Regional Meeting of Experts on Environmental Education in Latin America and the Caribbean, Bogota, Colombia, 24-30 November 1976. Final Report.

ERIC Educational Resources Information Center

United Nations Educational, Scientific, and Cultural Organization, Paris (France). Environmental Education Section.

This is the final report on the background and proceedings of the Regional Meeting on Environmental Education in Latin America and the Caribbean, convened jointly by UNESCO and the United Nations Environmental Program. The goal of this regional meeting was to examine the problems of the environment within the region, and to recommend lines for…

Congruences for central factorial numbers modulo powers of prime.

PubMed

Wang, Haiqing; Liu, Guodong

2016-01-01

Central factorial numbers are more closely related to the Stirling numbers than the other well-known special numbers, and they play a major role in a variety of branches of mathematics. In the present paper we prove some interesting congruences for central factorial numbers.

Midlands Teaching Factory, LTD.

ERIC Educational Resources Information Center

Midlands Technical Coll., Columbia, SC.

In 1987, Midlands Technical College (MTC), in Columbia, South Carolina, initiated a Computer Integrated Manufacturing (CIM) project, the Midlands Teaching Factory, LTD, which integrated various college departments with the goal of manufacturing a high quality, saleable product. The faculty developed a teaching factory model which was designed to…

Baby factories taint surrogacy in Nigeria.

PubMed

Makinde, Olusesan Ayodeji; Makinde, Olufunmbi Olukemi; Olaleye, Olalekan; Brown, Brandon; Odimegwu, Clifford O

2016-01-01

The practice of reproductive medicine in Nigeria is facing new challenges with the proliferation of 'baby factories'. Baby factories are buildings, hospitals or orphanages that have been converted into places for young girls and women to give birth to children for sale on the black market, often to infertile couples, or into trafficking rings. This practice illegally provides outcomes (children) similar to surrogacy. While surrogacy has not been well accepted in this environment, the proliferation of baby factories further threatens its acceptance. The involvement of medical and allied health workers in the operation of baby factories raises ethical concerns. The lack of a properly defined legal framework and code of practice for surrogacy makes it difficult to prosecute baby factory owners, especially when they are health workers claiming to be providing services to clients. In this environment, surrogacy and other assisted reproductive techniques urgently require regulation in order to define when ethico-legal lines have been crossed in providing surrogacy or surrogacy-like services. Copyright © 2015 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

Operating a production pilot factory serving several scientific domains

NASA Astrophysics Data System (ADS)

Sfiligoi, I.; Würthwein, F.; Andrews, W.; Dost, J. M.; MacNeill, I.; McCrea, A.; Sheripon, E.; Murphy, C. W.

2011-12-01

Pilot infrastructures are becoming prominent players in the Grid environment. One of the major advantages is represented by the reduced effort required by the user communities (also known as Virtual Organizations or VOs) due to the outsourcing of the Grid interfacing services, i.e. the pilot factory, to Grid experts. One such pilot factory, based on the glideinWMS pilot infrastructure, is being operated by the Open Science Grid at University of California San Diego (UCSD). This pilot factory is serving multiple VOs from several scientific domains. Currently the three major clients are the analysis operations of the HEP experiment CMS, the community VO HCC, which serves mostly math, biology and computer science users, and the structural biology VO NEBioGrid. The UCSD glidein factory allows the served VOs to use Grid resources distributed over 150 sites in North and South America, in Europe, and in Asia. This paper presents the steps taken to create a production quality pilot factory, together with the challenges encountered along the road.

Modeling the effect of preexisting joints on normal fault geometries using a brittle and cohesive material

NASA Astrophysics Data System (ADS)

Kettermann, M.; van Gent, H. W.; Urai, J. L.

2012-04-01

Brittle rocks, such as for example those hosting many carbonate or sandstone reservoirs, are often affected by different kinds of fractures that influence each other. Understanding the effects of these interactions on fault geometries and the formation of cavities and potential fluid pathways might be useful for reservoir quality prediction and production. Analogue modeling has proven to be a useful tool to study faulting processes, although usually the used materials do not provide cohesion and tensile strength, which are essential to create open fractures. Therefore, very fine-grained, cohesive, hemihydrate powder was used for our experiments. The mechanical properties of the material are scaling well for natural prototypes. Due to the fine grain size structures are preserved in in great detail. The used deformation box allows the formation of a half-graben and has initial dimensions of 30 cm width, 28 cm length and 20 cm height. The maximum dip-slip along the 60° dipping predefined basement fault is 4.5 cm and was fully used in all experiments. To setup open joints prior to faulting, sheets of paper placed vertically within the box to a depth of about 5 cm from top. The powder was then sieved into the box, embedding the paper almost entirely. Finally strings were used to remove the paper carefully, leaving open voids. Using this method allows the creation of cohesionless open joints while ensuring a minimum impact on the sensitive surrounding material. The presented series of experiments aims to investigate the effect of different angles between the strike of a rigid basement fault and a distinct joint set. All experiments were performed with a joint spacing of 2.5 cm and the fault-joint angles incrementally covered 0°, 4°, 8°, 12°, 16°, 20° and 25°. During the deformation time lapse photography from the top and side captured every structural change and provided data for post-processing analysis using particle imaging velocimetry (PIV). Additionally, stereo-photography at the final stage of deformation enabled the creation of 3D models to preserve basic geometric information. The models showed that at the surface the deformation localized always along preexisting joints, even when they strike at an angle to the basement-fault. In most cases faults intersect precisely at the maximum depth of the joints. With increasing fault-joint angle the deformation occurred distributed over several joints by forming stepovers with fractures oriented normal to the strike of the joints. No fractures were observed parallel to the basement fault. At low angles stepovers coincided with wedge-shaped structures between two joints that remain higher than the surrounding joint-fault intersection. The wide opening gap along the main fault allowed detailed observations of the fault planes at depth, which revealed (1) changing dips according to joint-fault angles, (2) slickenlines, (3) superimposed steepening fault-planes, causing sharp sawtooth-shaped structures. Comparison to a field analogue at Canyonlands National Park, Utah/USA showed similar structures and features such as vertical fault escarpments at the surface coinciding with joint-surfaces. In the field and in the models stepovers were observed as well as conjugate faulting and incremental fault-steepening.

The factorial structure of job-related affective well-being: Polish adaptation of the Warr's measure.

PubMed

Mielniczuk, Emilia; Łaguna, Mariola

2018-02-16

The first aim of the study reported in this article was to test the factorial structure of job-related affect in a Polish sample. The second aim was to develop the Polish adaptation of the Warr's job-related affective well-being measure published in 1990, which is designed to assess 4 types of affect at work: anxiety, comfort, depression, enthusiasm. A longitudinal study design with 2 measurement times was used for verifying the psychometric properties of the Polish version of the measure. The final sample consisted of 254 Polish employees from different professions. Participants were asked to fill in a set of questionnaires consisting of measures capturing job-related affective well-being, mood, and turnover intention. The first step of analysis was to test the theoretically-based structure of the job-related affective well-being measure in a Polish sample. The confirmatory factor analysis revealed that a 4-factor model best describes the structure of the measure in comparison to 5 alternative models. Next, reliability of this measure was assessed. All scales achieved good internal consistency and acceptable test-retest reliability after 2 weeks. Finally, the convergent and discriminant validity as well as the criterion and predictive validity of all job-related affective well-being scales was confirmed, based on correlations between job-related affect and mood as well as turnover intention. The results suggest that the Polish adaptation of Warr's job-related affective well-being measure can be used by scientists as well as by practitioners who aim at assessing 4 types of affective well-being at a work context. This work is available in Open Access model and licensed under a CC BY-NC 3.0 PL license.

Factory daughters, the family, and nuptiality in Java.

PubMed

Wolf, D L

1990-01-01

The commercialization of agriculture, increasing landlessness, and an expanding labor class in rural areas of Java are all the result of industrialization. This work discusses the effect of female employment on marriage patterns of women working in rural factories. The central point is that employment has not only increased the financial autonomy of these women, but also increased the level of control they have over the choice of marriage partners. The data set used for analysis consisted of the observations of all factory workers and all non-factory females age 15-24 located in an agricultural village. The observations were make over a 15 month period between 1981-83. A follow up visit was made in 1986 and the following conclusions were then made: 1) the village study gave detailed data, but the data set was not large enough, thus a follow up study that encompasses more people is called for; 2) young rural female factory workers are more likely to chose their marriage partners than those engaged in traditional village labor. Of those that married and worked in factories, their fertility rate was significantly lower, compared to non-factory workers. Factory workers also had different family structures, because they spent less time living in extended families because of a larger income for the couple. This study indicates that increased economic control results in increased life decision control. This changed the daughter's economic relationship with her family and gives her more control in marriage decisions.

78 FR 50054 - Environmental Impacts Statements; Notice of Availability

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-16

... Nottingham 301-496-7775. EIS No. 20130237, Final EIS, NMFS, NJ, FEIS Amendment 14 to the Atlantic Mackerel... and the U.S. Department of Agriculture's Forest Service are joint lead agencies for the above EIS. EIS...

Field study of an integral backwall bridge : final report.

DOT National Transportation Integrated Search

1996-01-01

Integral bridges offer reduced maintenance expenditures, primarily due to the elimination of deck expansion joints. The design of an integral bridge, however, is complicated by the soil-structure interaction associated with thermal movements. It has ...

Portland/Vancouver to Boise ITS corridor study : final report

DOT National Transportation Integrated Search

1997-07-01

This 18 month study, which began in September 1995, was initiated as a joint project between the Idaho Transportation Department, Oregon Department of Transportation, and Washington Department of Transportation, in cooperation with the Federal Highwa...

Medicare Program; Advancing Care Coordination Through Episode Payment Models (EPMs); Cardiac Rehabilitation Incentive Payment Model; and Changes to the Comprehensive Care for Joint Replacement Model (CJR). Final rule.

PubMed

2017-01-03

This final rule implements three new Medicare Parts A and B episode payment models, a Cardiac Rehabilitation (CR) Incentive Payment model and modifications to the existing Comprehensive Care for Joint Replacement model under section 1115A of the Social Security Act. Acute care hospitals in certain selected geographic areas will participate in retrospective episode payment models targeting care for Medicare fee-forservice beneficiaries receiving services during acute myocardial infarction, coronary artery bypass graft, and surgical hip/femur fracture treatment episodes. All related care within 90 days of hospital discharge will be included in the episode of care. We believe these models will further our goals of improving the efficiency and quality of care for Medicare beneficiaries receiving care for these common clinical conditions and procedures.

27 CFR 40.47 - Other businesses within factory.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2012-04-01 2011-04-01 true Other businesses within... AND TUBES, AND PROCESSED TOBACCO Administrative Provisions § 40.47 Other businesses within factory. (a) General. The appropriate TTB officer may authorize such other businesses within the factory of a...

27 CFR 40.47 - Other businesses within factory.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2014-04-01 2014-04-01 false Other businesses within... AND TUBES, AND PROCESSED TOBACCO Administrative Provisions § 40.47 Other businesses within factory. (a) General. The appropriate TTB officer may authorize such other businesses within the factory of a...

Using the American alligator and a repeated-measures design to place constraints on in vivo shoulder joint range of motion in dinosaurs and other fossil archosaurs.

PubMed

Hutson, Joel D; Hutson, Kelda N

2013-01-15

Using the extant phylogenetic bracket of dinosaurs (crocodylians and birds), recent work has reported that elbow joint range of motion (ROM) studies of fossil dinosaur forearms may be providing conservative underestimates of fully fleshed in vivo ROM. As humeral ROM occupies a more central role in forelimb movements, the placement of quantitative constraints on shoulder joint ROM could improve fossil reconstructions. Here, we investigated whether soft tissues affect the more mobile shoulder joint in the same manner in which they affect elbow joint ROM in an extant archosaur. This test involved separately and repeatedly measuring humeral ROM in Alligator mississippiensis as soft tissues were dissected away in stages to bare bone. Our data show that the ROMs of humeral flexion and extension, as well as abduction and adduction, both show a statistically significant increase as flesh is removed, but then decrease when the bones must be physically articulated and moved until they separate from one another and/or visible joint surfaces. A similar ROM pattern is inferred for humeral pronation and supination. All final skeletonized ROMs were less than initial fully fleshed ROMs. These results are consistent with previously reported elbow joint ROM patterns from the extant phylogenetic bracket of dinosaurs. Thus, studies that avoid separation of complementary articular surfaces may be providing fossil shoulder joint ROMs that underestimate in vivo ROM in dinosaurs, as well as other fossil archosaurs.

Microseismic monitoring of columnar jointed basalt fracture activity: a trial at the Baihetan Hydropower Station, China

NASA Astrophysics Data System (ADS)

Chen, Bing-Rui; Li, Qing-Peng; Feng, Xia-Ting; Xiao, Ya-Xun; Feng, Guang-Liang; Hu, Lian-Xing

2014-10-01

Severe stress release has occurred to the surrounding rocks of the typically columnar jointed basalt after excavation at the Baihetan Hydropower Station, Jinsha River, China, where cracking, collapse, and other types of failure may take place occasionally due to relaxation fracture. In order to understand the relaxation fracture characteristics of the columnar jointed basalt in the entire excavation process at the diversion tunnel of the Baihetan Hydropower Station, real-time microseismic monitoring tests were performed. First, the applicability of a geophone and accelerometer was analyzed in the columnar jointed basalt tunnel, and the results show that the accelerometer was more applicable to the cracking monitoring of the columnar jointed basalt. Next, the waveform characteristics of the microseismic signals were analyzed, and the microseismic signals were identified as follows: rock fracture signal, drilling signal, electrical signal, heavy vehicle passing signal, and blast signal. Then, the attenuation characteristics of the microseismic signals in the columnar jointed basalt tunnel were studied, as well as the types and characteristics of the columnar jointed basalt fracture. Finally, location analysis was conducted on the strong rock fracture events, in which four or more sensors were triggered, to obtain the temporal and spatial evolution characteristics and laws of the columnar jointed basalt relaxation fracture after excavation. The test results are not only of important reference value to the excavation and support of diversion tunnel at the Baihetan Hydropower Station, but also of great referential significance and value to the conduction of similar tests.

Chimpanzee ankle and foot joint kinematics: Arboreal versus terrestrial locomotion.

PubMed

Holowka, Nicholas B; O'Neill, Matthew C; Thompson, Nathan E; Demes, Brigitte

2017-09-01

Many aspects of chimpanzee ankle and midfoot joint morphology are believed to reflect adaptations for arboreal locomotion. However, terrestrial travel also constitutes a significant component of chimpanzee locomotion, complicating functional interpretations of chimpanzee and fossil hominin foot morphology. Here we tested hypotheses of foot motion and, in keeping with general assumptions, we predicted that chimpanzees would use greater ankle and midfoot joint ranges of motion during travel on arboreal supports than on the ground. We used a high-speed motion capture system to measure three-dimensional kinematics of the ankle and midfoot joints in two male chimpanzees during three locomotor modes: terrestrial quadrupedalism on a flat runway, arboreal quadrupedalism on a horizontally oriented tree trunk, and climbing on a vertically oriented tree trunk. Chimpanzees used relatively high ankle joint dorsiflexion angles during all three locomotor modes, although dorsiflexion was greatest in arboreal modes. They used higher subtalar joint coronal plane ranges of motion during terrestrial and arboreal quadrupedalism than during climbing, due in part to their use of high eversion angles in the former. Finally, they used high midfoot inversion angles during arboreal locomotor modes, but used similar midfoot sagittal plane kinematics across all locomotor modes. The results indicate that chimpanzees use large ranges of motion at their various ankle and midfoot joints during both terrestrial and arboreal locomotion. Therefore, we argue that chimpanzee foot anatomy enables a versatile locomotor repertoire, and urge caution when using foot joint morphology to reconstruct arboreal behavior in fossil hominins. © 2017 Wiley Periodicals, Inc.

Bioinspired Robotic Fingers Based on Pneumatic Actuator and 3D Printing of Smart Material.

PubMed

Yang, Yang; Chen, Yonghua; Li, Yingtian; Chen, Michael Z Q; Wei, Ying

2017-06-01

In this article, we have proposed a novel robotic finger design principle aimed to address two challenges in soft pneumatic grippers-the controllability of the stiffness and the controllability of the bending position. The proposed finger design is composed of a 3D printed multimaterial substrate and a soft pneumatic actuator. The substrate has four polylactic acid (PLA) segments interlocked with three shape memory polymer (SMP) joints, inspired by bones and joints in human fingers. By controlling the thermal energy of an SMP joint, the stiffness of the joints is modulated due to the dramatic change in SMP elastic modulus around its glass transition temperature (T g ). When SMP joints are heated above T g , they exhibit very small stiffness, allowing the finger to easily bend around the SMP joints if the attached soft actuator is actuated. When there is no force from the soft actuator, shape recovery stress in SMP contributes to the finger's shape restoration. Since each joint's rotation can be individually controlled, the position control of the finger is made possible. Experimental analysis has been conducted to show the finger's variable stiffness and the result is compared with the analytical values. It is found that the stiffness ratio can be 24.9 times for a joint at room temperature (20°C) and at an elevated temperature of 60°C when air pressure p of the soft actuator is turned off. Finally, a gripper composed of two fingers is fabricated for demonstration.

Post-operative bracing after ACL reconstruction has no effect on knee joint effusion. A prospective, randomized study.

PubMed

Lindström, Maria; Wredmark, Torsten; Wretling, Marie-Louise; Henriksson, Marketta; Felländer-Tsai, Li

2015-12-01

It is unclear what factors contribute to knee joint effusion after anterior cruciate ligament (ACL) injury and reconstruction. Knee homeostasis after injury and surgery is crucial for rehabilitation and knee well-being. We examined if effusion was affected by post-operative bracing, and if patients with effusion fit into a common profile. Patients were randomized to wearing or not wearing a post-operative brace for three weeks after ACL reconstruction with semitendinosus-gracilis tendons. Knee joint effusion was detected by computed tomography in 60 patients (22 women), before and three and 12 months after surgery. Joint effusion, clinical and subjective tests were analyzed. This is the first prospective, randomized study on post-operative bracing for patients with a semitendinosus-gracilis graft showed that bracing had no effect on three-months presence of joint effusion. Excessive joint effusion was present in 68% of the patients three months after surgery and was associated to prior meniscus injury (p=0.05) and higher prior Tegner activity level (p=0.006). We found a positive association between longer time from injury to surgery and joint effusion three months post-operatively (rho=0.29, p<0.05). Twelve months post-operatively, joint effusion had diminished to baseline levels. Subjective scores and activity levels were lower for women. Three-months joint effusion predicted lower final outcome scores in women. Prior meniscus injury and pre-injury Tegner activity levels are predictive significant variables for excessive knee joint effusion after ACL reconstruction. Post-operative bracing had no effect. A larger clinical cohort is needed to confirm findings of this logistic regression. Copyright © 2015 Elsevier B.V. All rights reserved.

Sacroiliac joint tuberculosis: surgical management by posterior open-window focal debridement and joint fusion.

PubMed

Zhu, Guo; Jiang, Li-Yuan; Yi, Zhang; Ping, Li; Duan, Chun-Yue; Yong, Cao; Liu, Jin-Yang; Hu, Jian-Zhong

2017-11-29

Sacroiliac joint tuberculosis(SJT) is relatively uncommon, but it may cause severe sacroiliac joint destruction and functional disorder. Few studies in the literature have been presented on SJT, reports of surgical treatment for SJT are even fewer. In this study, we retrospectively reviewed surgical management of patients with severe SJT of 3 different types and proposed to reveal the clinical manifestations and features and aim to determine the efficiency and security of such surgical treatment. We reviewed 17 patients with severe SJT of 3 different types who underwent posterior open-window focal debridement and bone graft for joint fusion. Among them,five patients with anterior sacral abscess had anterior abscess curettage before debridement. Two patients with lumbar vertebral tuberculosis received one-stage posterior tuberculous debridement, interbody fusion and instrumentation. Follow-up was performed 36 months (26 to 45 months) using the following parameters: erythrocyte sedimentation rate(ESR), status of joint bony fusion on CT scan, visual analogue scale (VAS) and the Oswestry Disability Index (ODI). Buttock pain and low back pain were progressively relieved with time. 6 months later, pain was not obvious, and ESR resumed to normal levels within 3 months. Solid fusion of the sacroiliac joint occurred within 12 months in all cases. No complications or recurrence occurred. At final follow-up, all patients had no pain or only minimal discomfort over the affected joint and almost complete functional recovery. Posterior open-window focal debridement and joint fusion is an efficient and secure surgical method to treat severe SJT. If there is an abscess in the front of the sacroiliac joint, anterior abscess curettage should be performed as a supplement.

The effects of local anaesthetic solution in the navicular bursa of horses with lameness caused by distal interphalangeal joint pain.

PubMed

Schumacher, John; Schumacher, Jim; Gillette, R; DeGraves, F; Schramme, M; Smith, R; Perkins, J; Coker, M

2003-07-01

Analgesia of the palmar digital (PD) nerves has been demonstrated to cause analgesia of the distal interphalangeal (DIP) joint as well as the sole. Because the PD nerves lie in close proximity to the navicular bursa, we suspected that that analgesia of the navicular bursa would anaesthetise the PD nerves, which would result in analgesia of the DIP joint. To determine the response of horses with pain in the DIP joint to instillation of local anaesthetic solution into the navicular bursa. Lameness was induced in 6 horses by creating painful synovitis in the DIP joint of one forefoot by administering endotoxin into the joint. Horses were videorecorded while trotting, before and after induction of lameness, at three 10 min intervals after instilling 3.5 ml local anaesthetic solution into the navicular bursa and, finally, after instilling 6 ml solution into the DIP joint. Lameness scores were assigned by grading the videorecorded gaits subjectively. At the 10 and -20 min observations, median lameness scores were not significantly different from those before administration of local anaesthetic solution into the navicular bursa (P > or = 0.05), although lameness scores of 3 of 6 horses improved during this period, and the 20 min observation scores tended toward significance (P = 0.07). At the 30 min observation, and after analgesia of the DIP joint, median lameness scores were significantly improved (P < or = 0.05). These results indicate that pain arising from the DIP joint can probably be excluded as a cause of lameness, when lameness is attenuated within 10 mins by analgesia of the navicular bursa. Pain arising from the DIP joint cannot be excluded as a cause of lameness when lameness is attenuated after 20 mins after analgesia of the navicular bursa.

A rapid biochemical test to assess postharvest deterioration of sugarcane and milled juice

USDA-ARS?s Scientific Manuscript database

The delivery of consignments of deteriorated sugarcane to factories can detrimentally affect multiple process units, and even lead to a factory shut-down. An enzymatic factory method was used to measure mannitol, a major degradation product of sugarcane Leuconostoc deterioration in the U.S., in pre...

Factorial versus Typological Models: A Comparison of Methods for Personality Data

ERIC Educational Resources Information Center

von Davier, Matthias; Naemi, Bobby; Roberts, Richard D.

2012-01-01

This article describes an exploration of the distinction between typological and factorial latent variables in the domain of personality theory. Traditionally, many personality variables have been considered to be factorial in nature, even though there are examples of typological constructs dating back to Hippocrates. Recently, some…

A community-initiated study of blood lead levels of Nicaraguan children living near a battery factory.

PubMed Central

Morales Bonilla, C; Mauss, E A

1998-01-01

OBJECTIVES: In response to requests by parents in Managua, Nicaragua, whose neighborhood borders a battery factory, 97 children were tested for blood lead, as were 30 children in a neighborhood without an obvious source of environmental lead. METHODS: Venous blood was examined by atomic absorption spectrophotometry. Educational workshops were conducted. RESULTS: Mean blood lead levels were 17.21 +/- 9.92 micrograms/dL in the index children and 7.40 +/- 5.37 micrograms/dL in the controls (P < .001). CONCLUSIONS: Children living near the battery factory are at increased risk of lead poisoning. The parents were able to petition the government to control the factory emissions and to improve appropriate health services. The factory is now closed. PMID:9842385

A reference architecture for the component factory

NASA Technical Reports Server (NTRS)

Basili, Victor R.; Caldiera, Gianluigi; Cantone, Giovanni

1992-01-01

Software reuse can be achieved through an organization that focuses on utilization of life cycle products from previous developments. The component factory is both an example of the more general concepts of experience and domain factory and an organizational unit worth being considered independently. The critical features of such an organization are flexibility and continuous improvement. In order to achieve these features we can represent the architecture of the factory at different levels of abstraction and define a reference architecture from which specific architectures can be derived by instantiation. A reference architecture is an implementation and organization independent representation of the component factory and its environment. The paper outlines this reference architecture, discusses the instantiation process, and presents some examples of specific architectures by comparing them in the framework of the reference model.

Acoustic scale modelling of factories, part II: 1-50 Cale model investigations of factory sound fields

NASA Astrophysics Data System (ADS)

Hodgson, M. R.; Orlowski, R. J.

1987-03-01

In this second part of a report on factory scale modelling use of a 1:50 scale variable model as a research tool is described. Details of the model are presented. The results of measurements of reverberation time and sound propagation, made in various model configurations, are used to investigate the main factors influencing factory sound fields, and the applicability of the Sabine theory to factories. The parameters investigated are the enclosure geometry (aspect ratio, volume and roof pitch), surface absorption and fittings (density, size, surface area, vertical distribution and specific types). Despite certain limitations and uncertainties resulting, for example, from surprising results associated with surface absorption, models are shown to be effective research tools. The inapplicability of the Sabine theory is confirmed and elucidated.

Implementing Clinical Research Using Factorial Designs: A Primer.

PubMed

Baker, Timothy B; Smith, Stevens S; Bolt, Daniel M; Loh, Wei-Yin; Mermelstein, Robin; Fiore, Michael C; Piper, Megan E; Collins, Linda M

2017-07-01

Factorial experiments have rarely been used in the development or evaluation of clinical interventions. However, factorial designs offer advantages over randomized controlled trial designs, the latter being much more frequently used in such research. Factorial designs are highly efficient (permitting evaluation of multiple intervention components with good statistical power) and present the opportunity to detect interactions amongst intervention components. Such advantages have led methodologists to advocate for the greater use of factorial designs in research on clinical interventions (Collins, Dziak, & Li, 2009). However, researchers considering the use of such designs in clinical research face a series of choices that have consequential implications for the interpretability and value of the experimental results. These choices include: whether to use a factorial design, selection of the number and type of factors to include, how to address the compatibility of the different factors included, whether and how to avoid confounds between the type and number of interventions a participant receives, and how to interpret interactions. The use of factorial designs in clinical intervention research poses choices that differ from those typically considered in randomized clinical trial designs. However, the great information yield of the former encourages clinical researchers' increased and careful execution of such designs. Copyright © 2017. Published by Elsevier Ltd.

"Mixing" as an ethnoetiology of HIV/AIDS in Malaysia's multinational factories.

PubMed

Root, Robin

2006-09-01

Minah Karan, the stigmatizing label appended to Malay factory women in the 1980s, signaled a dangerous female sexuality that risked spreading beyond the factory gates and infecting Malaysia's idea(l)s of its traditional kampung culture. This article narrates how Minah Karan, as the former antihero of development, was reconstituted in the 1990s, with the government's labeling of factories as "high-risk settings" for HIV/AIDS. This is an ethnoetiology based not on any evidential epidemiological data but on the racial and gendered "mixing" that transpires behind factory walls: a fear that the "mixing of the sexes" means ipso facto "sexual mixing" among the races. The article demonstrates how importation of the high-risk label articulates at the local level the new and contested linkages, economic, religious, and scientific, constitutive of globalization. The pragmatic nature and imperatives of this high-risk process are discerned in factory women's accounts of how they negotiate the interactional imperatives of factory work, because transnational structures of productivity violate the social boundaries that have long connoted political stability, moral integrity, ethnic community, and individual safety. The article concludes by questioning whether ethnoetiologies, especially when they concern sexual networks, become social etiologies, because this would locate ethnoetiologies as central to conventional public health praxis rather than as ethnographic exotica in the margins.

Improvement in latent variable indirect response joint modeling of a continuous and a categorical clinical endpoint in rheumatoid arthritis.

PubMed

Hu, Chuanpu; Zhou, Honghui

2016-02-01

Improving the quality of exposure-response modeling is important in clinical drug development. The general joint modeling of multiple endpoints is made possible in part by recent progress on the latent variable indirect response (IDR) modeling for ordered categorical endpoints. This manuscript aims to investigate, when modeling a continuous and a categorical clinical endpoint, the level of improvement achievable by joint modeling in the latent variable IDR modeling framework through the sharing of model parameters for the individual endpoints, guided by the appropriate representation of drug and placebo mechanism. This was illustrated with data from two phase III clinical trials of intravenously administered mAb X for the treatment of rheumatoid arthritis, with the 28-joint disease activity score (DAS28) and 20, 50, and 70% improvement in the American College of Rheumatology (ACR20, ACR50, and ACR70) disease severity criteria were used as efficacy endpoints. The joint modeling framework led to a parsimonious final model with reasonable performance, evaluated by visual predictive check. The results showed that, compared with the more common approach of separately modeling the endpoints, it is possible for the joint model to be more parsimonious and yet better describe the individual endpoints. In particular, the joint model may better describe one endpoint through subject-specific random effects that would not have been estimable from data of this endpoint alone.

Development of a procedure for forming assisted thermal joining of tubes

NASA Astrophysics Data System (ADS)

Chen, Hui; Löbbe, Christian; Staupendahl, Daniel; Tekkaya, A. Erman

2018-05-01

With the demand of lightweight design in the automotive industry, not only the wall-thicknesses of tubular components of the chassis or spaceframe are continuously decreased. Also the thicknesses of exhaust system parts are reduced to save material and mass. However, thinner tubular parts bring about additional challenges in joining. Welding or brazing methods, which are utilized in joining tubes with specific requirements concerning leak tightness, are sensitive to the gap between the joining partners. Furthermore, a large joining area is required to ensure the durability of the joint. The introduction of a forming step in the assembled state prior to thermal joining can define and control the gap for subsequent brazing or welding. The mechanical pre-joint resulting from the previously described calibration step also results in easier handling of the tubes prior to thermal joining. In the presented investigation, a spinning process is utilized to produce force-fit joints of varying lengths and diameter reduction and form-fit joints with varying geometrical attributes. The spinning process facilitates a high formability and geometrical flexibility, while at the achievable precision is high and the process forces are low. The strength of the joints is used to evaluate the joint quality. Finally, a comparison between joints produced by forming with subsequent brazing and original tube is conducted, which presents the high performance of the developed procedure for forming assisted thermal joining.

Hybrid FSWeld-bonded joint fatigue behaviour

NASA Astrophysics Data System (ADS)

Lertora, Enrico; Mandolfino, Chiara; Gambaro, Carla; Pizzorni, Marco

2018-05-01

Aluminium alloys, widely used in aeronautics, are increasingly involved in the automotive industry due to the good relationship between mechanical strength and specific weight. The lightening of the structures is the first objective, which allows the decreasing in the weight in motion. The use of aluminium alloys has also seen the introduction of the Friction Stir Welding (FSW) technique for the production of structural overlapping joints. FSW allows us to weld overlap joints free from defects, but with the presence of a structural notch further aggravated by the presence of a "hook" defect near the edge of the weld. Furthermore, FSW presents a weld penetration area connected to the tool geometry and penetration. The experimental activity will be focused on the combination of two different joining techniques, which can synergistically improve the final joint resistance. In particular, the welding and bonding process most commonly known as weld-bonding is defined as a hybrid process, as it combines two different junction processes. In this paper we analyse FSWelded AA6082 aluminium alloy overlapped joint with the aim of quantitatively evaluating the improvement provided by the presence of an epoxy adhesive between the plates. After optimising the weld-bonding process, the mechanical behaviour of welded joints will be analysed by static and dynamic tests. The presence of the adhesive should limit the negative effect of the structural notch inevitable in a FSW overlapped joint.

A new programming metaphor for image processing procedures

NASA Technical Reports Server (NTRS)

Smirnov, O. M.; Piskunov, N. E.

1992-01-01

Most image processing systems, besides an Application Program Interface (API) which lets users write their own image processing programs, also feature a higher level of programmability. Traditionally, this is a command or macro language, which can be used to build large procedures (scripts) out of simple programs or commands. This approach, a legacy of the teletypewriter has serious drawbacks. A command language is clumsy when (and if! it attempts to utilize the capabilities of a multitasking or multiprocessor environment, it is but adequate for real-time data acquisition and processing, it has a fairly steep learning curve, and the user interface is very inefficient,. especially when compared to a graphical user interface (GUI) that systems running under Xll or Windows should otherwise be able to provide. ll these difficulties stem from one basic problem: a command language is not a natural metaphor for an image processing procedure. A more natural metaphor - an image processing factory is described in detail. A factory is a set of programs (applications) that execute separate operations on images, connected by pipes that carry data (images and parameters) between them. The programs function concurrently, processing images as they arrive along pipes, and querying the user for whatever other input they need. From the user's point of view, programming (constructing) factories is a lot like playing with LEGO blocks - much more intuitive than writing scripts. Focus is on some of the difficulties of implementing factory support, most notably the design of an appropriate API. It also shows that factories retain all the functionality of a command language (including loops and conditional branches), while suffering from none of the drawbacks outlined above. Other benefits of factory programming include self-tuning factories and the process of encapsulation, which lets a factory take the shape of a standard application both from the system and the user's point of view, and thus be used as a component of other factories. A bare-bones prototype of factory programming was implemented under the PcIPS image processing system, and a complete version (on a multitasking platform) is under development.

TILT : the Treasure Island Liquefaction Test : final report

DOT National Transportation Integrated Search

2002-01-01

This report presents the results of the Treasure Island Liquefaction Test (TILT), a joint project carried out by University of California, San Diego, and Brigham Young University. To improve our understanding of the lateral load behavior of deep foun...

NSF final project report planning and implementation of the U.S. Joint Global Ocean Flux Study (U.S. JGOFS)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Livingston, Hugh D.

1996-07-01

Conducted planning and implementation of ocean carbon dioxide hydrographic surveys ocean process studies, time-series studies of Bermuda and Hawaii, and sponsored scientific workshops for those activities.

The manufacture of generic replicas of implants for arthroplasty of the hip and knee: is it regulated and will it save money?

PubMed

Atrey, A; Heylen, S; Gosling, O; Porteous, M J L; Haddad, F S

2016-07-01

Joint replacement of the hip and knee remain very satisfactory operations. They are, however, expensive. The actual manufacturing of the implant represents only 30% of the final cost, while sales and marketing represent 40%. Recently, the patents on many well established and successful implants have expired. Companies have started producing and distributing implants that purport to replicate existing implants with good long-term results. The aims of this paper are to assess the legality, the monitoring and cost saving implications of such generic implants. We also assess how this might affect the traditional orthopaedic implant companies. Cite this article: Bone Joint J 2016;98-B:892-900. ©2016 The British Editorial Society of Bone & Joint Surgery.

Intra-household work time synchronization: Togetherness or material benefits?

PubMed

van Klaveren, Chris; van den Brink, Henriette Maassen

2007-10-01

If partners derive utility from joint leisure time, it is expected that they will coordinate their work schedules in order to increase the amount of joint leisure. In order to control for differences in constraints and selection effects, this paper uses a new matching procedure, providing answers to the following questions: (1) Do partners coordinate their work schedules and does this result in work time synchronization?; (2) which partners synchronize more work hours?; and (3) is there a preference for togetherness? We find that coordination results in more synchronized work hours. The presence of children in the household is the main cause why some partners synchronize their work times less than other partners. Finally, partners coordinate their work schedules in order to have more joint leisure time, which is evidence for togetherness preferences.

Operational framework for quantum measurement simulability

NASA Astrophysics Data System (ADS)

Guerini, Leonardo; Bavaresco, Jessica; Terra Cunha, Marcelo; Acín, Antonio

2017-09-01

We introduce a framework for simulating quantum measurements based on classical processing of a set of accessible measurements. Well-known concepts such as joint measurability and projective simulability naturally emerge as particular cases of our framework, but our study also leads to novel results and questions. First, a generalisation of joint measurability is derived, which yields a hierarchy for the incompatibility of sets of measurements. A similar hierarchy is defined based on the number of outcomes necessary to perform a simulation of a given measurement. This general approach also allows us to identify connections between different kinds of simulability and, in particular, we characterise the qubit measurements that are projective-simulable in terms of joint measurability. Finally, we discuss how our framework can be interpreted in the context of resource theories.

A neural network for controlling the configuration of frame structure with elastic members

NASA Technical Reports Server (NTRS)

Tsutsumi, Kazuyoshi

1989-01-01

A neural network for controlling the configuration of frame structure with elastic members is proposed. In the present network, the structure is modeled not by using the relative angles of the members but by using the distances between the joint locations alone. The relationship between the environment and the joints is also defined by their mutual distances. The analog neural network attains the reaching motion of the manipulator as a minimization problem of the energy constructed by the distances between the joints, the target, and the obstacles. The network can generate not only the final but also the transient configurations and the trajectory. This framework with flexibility and parallelism is very suitable for controlling the Space Telerobotic systems with many degrees of freedom.

Final Environmental Assessment: Replacement Joint Force Headquarters Building, Hanscom Air Force Base Massachusetts

DTIC Science & Technology

2010-01-22

MANG and the Air Force. A public notice was published in the Boston Globe and the local papers for Lincoln, Concord, Bedford, and Lexington on December...industrial areas. The types of solid waste generated include food, various grades of office paper , newspaper, Final Environmental Assessment...gas ranges and dryers . Additionally, natural gas is consumed by various other facilities on base including the child care center, the Officer’s Club

Design, analysis and presentation of factorial randomised controlled trials

PubMed Central

Montgomery, Alan A; Peters, Tim J; Little, Paul

2003-01-01

Background The evaluation of more than one intervention in the same randomised controlled trial can be achieved using a parallel group design. However this requires increased sample size and can be inefficient, especially if there is also interest in considering combinations of the interventions. An alternative may be a factorial trial, where for two interventions participants are allocated to receive neither intervention, one or the other, or both. Factorial trials require special considerations, however, particularly at the design and analysis stages. Discussion Using a 2 × 2 factorial trial as an example, we present a number of issues that should be considered when planning a factorial trial. The main design issue is that of sample size. Factorial trials are most often powered to detect the main effects of interventions, since adequate power to detect plausible interactions requires greatly increased sample sizes. The main analytical issues relate to the investigation of main effects and the interaction between the interventions in appropriate regression models. Presentation of results should reflect the analytical strategy with an emphasis on the principal research questions. We also give an example of how baseline and follow-up data should be presented. Lastly, we discuss the implications of the design, analytical and presentational issues covered. Summary Difficulties in interpreting the results of factorial trials if an influential interaction is observed is the cost of the potential for efficient, simultaneous consideration of two or more interventions. Factorial trials can in principle be designed to have adequate power to detect realistic interactions, and in any case they are the only design that allows such effects to be investigated. PMID:14633287

A Survey of the Medical Needs of a Group of Small Factories*

PubMed Central

Lee, W. R.

1962-01-01

The present interest in medical services for small factories is matched by the limited objective information which is available on the demand for and needs of such services. As a teaching project, a survey was made of factories with between 30 and 200 employees on an estate in the North West where there was no organized medical service. Unfortunately, time allowed only 22 factories to be visited. The findings, therefore, are regarded as indicative rather than conclusive, but this does not detract from their interest. Factories were visited by two or three postgraduate students who completed a questionnaire designed to standardize their findings. The questionnaire is included as an appendix to this paper. Regarding the demand for medical services, four of the 22 factories were subsidiaries of larger organizations and had part-time medical advice, 14 expressed no interest even if this would have involved no financial commitment, and the remaining four were interested for differing reasons. The needs of the factories in this context were found to be, first, advice and perhaps better supervision of non-mechanical hazards and, secondly, supervision of the first aid arrangements. From the ambulance journey records of the local authority there appeared to be no great demand for local casualty facilities. To meet these needs it is suggested that the functions of the appointed factory doctor might be modified to include wider supervision of non-mechanical hazards and supervision of first aid arrangements. It is also suggested that the National Health Service should form the basis for dealing with those cases requiring more than first aid. PMID:14463582

Proposal for research and education: joint lectures and practicals on central nervous system anatomy and physiology.

PubMed

Kageyama, Ikuo; Yoshimura, Ken; Satoh, Yoshihide; Nanayakkara, Chinthani D; Pallegama, Ranjith W; Iwasaki, Shin-Ichi

2016-07-01

We coordinated anatomy and physiology lectures and practicals to facilitate an integrated understanding of morphology and function in a basic medical science program for dental students and to reduce the time spent on basic science education. This method is a means to provide the essential information and skills in less time. The overall impression was that the practice of joint central nervous system lectures and practicals was an efficient method for students, which suggests that joint lectures might also be useful for clinical subjects. About two-thirds of students felt that the joint anatomy and physiology lecture on the central nervous system was useful and necessary in understanding the relationship between morphology and function, at least for this subject. One-third of students were neutral on the effectiveness of this method. However, the survey results suggest that improvements are needed in the method and timing of joint lectures and practicals. The present teaching approach can be further improved by conducting combined lectures in which the form and function of anatomic structures are presented by the relevant departments during the same lecture. Finally, joint lecturers and practicals offer an opportunity to increase student understanding of the importance of new research findings by the present authors and other researchers.

Shoe midsole longitudinal bending stiffness and running economy, joint energy, and EMG.

PubMed

Roy, Jean-Pierre R; Stefanyshyn, Darren J

2006-03-01

It has been shown that mechanical energy is dissipated at the metatarsophalangeal (MTP) joint during running and jumping. Furthermore, increasing the longitudinal bending stiffness of the midsole significantly reduced the energy dissipated at the MTP joint and increased jump performance. It was hypothesized that increasing midsole longitudinal bending stiffness would also lead to improvements in running economy. This study investigated the influence of midsole longitudinal bending stiffness on running economy (performance variable) and evaluated the local effects on joint energetics and muscular activity. Carbon fiber plates were inserted into running shoe midsoles and running economy, joint energy, and electromyographic (EMG) data were collected on 13 subjects. Approximately a 1% metabolic energy savings was observed when subjects ran in a stiff midsole relative to the control midsole. Subjects with a greater body mass had a greater decrease in oxygen consumption rates in the stiff midsole relative to the control midsole condition. The stiffer midsoles showed no significant differences in energy absorption at the MTP joint compared with the control shoe. Finally, no significant changes were observed in muscular activation. Increasing midsole longitudinal bending stiffness led to improvements in running economy, yet the underlying mechanisms that can be attributed to this improvement are still not fully understood.

Atlantoaxial Joint Distraction with a New Expandable Device for the Treatment of Basilar Invagination with Preservation of the C2 Nerve Root: A Cadaveric Anatomical Study.

PubMed

Polli, Filippo Maria; Trungu, Sokol; Miscusi, Massimo; Forcato, Stefano; Visocchi, Massimiliano; Raco, Antonino

2017-01-01

Atlantoaxial joint distraction has been advocated for the decompression of the brain stem in patients affected by basilar invagination, avoiding direct transoral decompression. This technique requires C2 ganglion resection and it is often impossible to perform due to the peculiar bony anatomy. We describe a cadaveric anatomical study supporting the feasibility of C1-C2 distraction performed with an expandable device, allowing easier insertion of the tool and preservation of the C2 nerve root. In five adult cadaveric specimens, posterior atlantoaxial surgical exposure was performed and an expandable system was inserted within the C1-C2 joint. The expansion of the device, leading to active distraction of the joint space, together with all the surgical steps of the technique was recorded with anatomical pictures and the final results were checked with a computed tomography (CT) scan. Insertion of the device was easily performed in all cases without anatomical conflict with the C2 ganglion; CT scans confirmed the distraction of the C1-C2 joint. This cadaveric anatomical study confirms the feasibility of the introduction of an expandable and flexible device within the C1-C2 joint, allowing it's distraction and preservation of the C2 ganglion.

Coracoclavicular joint: osteologic study of 1020 human clavicles

PubMed Central

Gumina, S; Salvatore, M; De Santis, P; Orsina, L; Postacchini, F

2002-01-01

We examined 1020 dry clavicles from cadavers of Italian origin to determine the prevalence of the coracoclavicular joint (ccj), a diarthrotic synovial joint occasionally present between the conoid tubercle of the clavicle and the superior surface of the horizontal part of the coracoid process. Five hundred and nine clavicles from individuals of different ages were submitted to X-ray examination. Using radiography, we measured the entire length and the index of sinuosity of the anterior lateral curve, on which the distance between the conoid tubercle and the coracoid process depends. We also used radiography to record the differences in prevalence of arthritis in two neighbouring joints, the acromioclavicular and sternoclavicular joints. Of the 1020 clavicles, eight (0.8%) displayed the articular facet of the ccj. No statistical correlation was found between clavicular length and the index of sinuosity of the anterior lateral curve. The prevalence of arthritis in clavicles with ccj was higher than that revealed in clavicles without ccj. The prevalence of ccj in the studied clavicles is lower than that observed in Asian cohorts. Furthermore, ccj is not conditioned by either length or sinuosity of the anterior lateral curve of the clavicle. Finally, the assumption that ccj is a predisposing factor for degenerative changes of neighbouring joints is statistically justified. PMID:12489763

Moje first metatarsophalangeal replacement--a case series with functional outcomes using the AOFAS-HMI score.

PubMed

Brewster, Mark; McArthur, John; Mauffrey, Cyril; Lewis, Andrew Charles; Hull, Peter; Ramos, James

2010-01-01

We report the functional results of a case series of Moje first metatarsophalangeal total joint replacements carried out between February 2001 and November 2006. All patients who underwent Moje arthroplasty under the care of a single surgeon were included; outcome scores and complications were recorded annually. A total of 32 joints in 29 consecutive patients were followed for a mean duration of 34 (range 6 to 74) months, and the mean patient age at the time of operation was 56 (range 38 to 79) years. Hallux rigidus was the primary diagnosis in 28 (87.5%) of the cases. The mean American Orthopaedic Foot & Ankle Society Hallux-Metatarsophalangeal-Interphalangeal score at final follow-up was 74/100 (range 9 to 100), with 13 (40.63%) joints rated good to excellent. Two (6.25%) joints were revised to arthrodesis at a mean of 52 (range 41 to 63) months following the arthroplasty procedure, and the overall prevalence of postoperative complications was 6 (18.75%). Based on these results, we concluded that first MTPJ total joint replacement with the Moje device remains promising, but still has room for improvement before the results match those obtained with larger joint (knee, hip) arthroplasty. Copyright 2010 American College of Foot and Ankle Surgeons. Published by Elsevier Inc. All rights reserved.

Advanced process control framework initiative

NASA Astrophysics Data System (ADS)

Hill, Tom; Nettles, Steve

1997-01-01

The semiconductor industry, one the world's most fiercely competitive industries, is driven by increasingly complex process technologies and global competition to improve cycle time, quality, and process flexibility. Due to the complexity of these problems, current process control techniques are generally nonautomated, time-consuming, reactive, nonadaptive, and focused on individual fabrication tools and processes. As the semiconductor industry moves into higher density processes, radical new approaches are required. To address the need for advanced factory-level process control in this environment, Honeywell, Advanced Micro Devices (AMD), and SEMATECH formed the Advanced Process Control Framework Initiative (APCFI) joint research project. The project defines and demonstrates an Advanced Process Control (APC) approach based on SEMATECH's Computer Integrated Manufacturing (CIM) Framework. Its scope includes the coordination of Manufacturing Execution Systems, process control tools, and wafer fabrication equipment to provide necessary process control capabilities. Moreover, it takes advantage of the CIM Framework to integrate and coordinate applications from other suppliers that provide services necessary for the overall system to function. This presentation discusses the key concept of model-based process control that differentiates the APC Framework. This major improvement over current methods enables new systematic process control by linking the knowledge of key process settings to desired product characteristics that reside in models created with commercial model development tools The unique framework-based approach facilitates integration of commercial tools and reuse of their data by tying them together in an object-based structure. The presentation also explores the perspective of each organization's involvement in the APCFI project. Each has complementary goals and expertise to contribute; Honeywell represents the supplier viewpoint, AMD represents the user with 'real customer requirements', and SEMATECH provides a consensus-building organization that widely disseminates technology to suppliers and users in the semiconductor industry that face similar equipment and factory control systems challenges.

Factorial inferential grid grouping and representativeness analysis for a systematic selection of representative grids

NASA Astrophysics Data System (ADS)

Cheng, Guanhui; Huang, Guohe; Dong, Cong; Xu, Ye; Yao, Yao

2017-08-01

A factorial inferential grid grouping and representativeness analysis (FIGGRA) approach is developed to achieve a systematic selection of representative grids in large-scale climate change impact assessment and adaptation (LSCCIAA) studies and other fields of Earth and space sciences. FIGGRA is applied to representative-grid selection for temperature (Tas) and precipitation (Pr) over the Loess Plateau (LP) to verify methodological effectiveness. FIGGRA is effective at and outperforms existing grid-selection approaches (e.g., self-organizing maps) in multiple aspects such as clustering similar grids, differentiating dissimilar grids, and identifying representative grids for both Tas and Pr over LP. In comparison with Pr, the lower spatial heterogeneity and higher spatial discontinuity of Tas over LP lead to higher within-group similarity, lower between-group dissimilarity, lower grid grouping effectiveness, and higher grid representativeness; the lower interannual variability of the spatial distributions of Tas results in lower impacts of the interannual variability on the effectiveness of FIGGRA. For LP, the spatial climatic heterogeneity is the highest in January for Pr and in October for Tas; it decreases from spring, autumn, summer to winter for Tas and from summer, spring, autumn to winter for Pr. Two parameters, i.e., the statistical significance level (α) and the minimum number of grids in every climate zone (Nmin), and their joint effects are significant for the effectiveness of FIGGRA; normalization of a nonnormal climate-variable distribution is helpful for the effectiveness only for Pr. For FIGGRA-based LSCCIAA studies, a low value of Nmin is recommended for both Pr and Tas, and a high and medium value of α for Pr and Tas, respectively.

Lessons learnt from a factory fire with asbestos-containing fallout.

PubMed

Bridgman, S A

1999-06-01

Fallout containing asbestos from a factory fire at Tranmere, Wirral, England, landed on a highly populated urban area with an estimated 16000 people living in the area worst affected, which included a shipbuilding community. There was considerable public concern over the health impact of the acute environmental incident, and great media interest. A descriptive study was carried out of the acute environmental incident and its management, and the difficulties encountered. Practical lessons learnt include need for: increased fire-fighter awareness of potential adverse health effects from asbestos in the structure of buildings; early involvement of both Local Authority environmental health and National Health Service public health departments; creation of a systematic local database of potential environmental health hazards in the structure of buildings as well as their contents; 24 hour on-call arrangements with laboratories expert in analyses of fire fallout; rapid quantitative analyses of multiple environmental samples; district written policy on handling asbestos incidents; systematic assessment of fright and media factors in public impact of an incident; dedicated public help-lines open long hours; consistent evidence-based public messages from all those communicating with the public; measurement of asbestos levels in the street and homes for public reassurance; local and health authorities' subscription to an environmental incident support service; formation of an acute environmental incident team to jointly manage and publicly report on airborne acute environmental incidents; clear government definition of responsibilities of different agencies. This paper provides a description of important lessons learnt during an acute environmental incident with asbestos-containing fallout. It will be helpful to those involved in the practical planning for and management of future incidents.

Simultaneous Calibration: A Joint Optimization Approach for Multiple Kinect and External Cameras.

PubMed

Liao, Yajie; Sun, Ying; Li, Gongfa; Kong, Jianyi; Jiang, Guozhang; Jiang, Du; Cai, Haibin; Ju, Zhaojie; Yu, Hui; Liu, Honghai

2017-06-24

Camera calibration is a crucial problem in many applications, such as 3D reconstruction, structure from motion, object tracking and face alignment. Numerous methods have been proposed to solve the above problem with good performance in the last few decades. However, few methods are targeted at joint calibration of multi-sensors (more than four devices), which normally is a practical issue in the real-time systems. In this paper, we propose a novel method and a corresponding workflow framework to simultaneously calibrate relative poses of a Kinect and three external cameras. By optimizing the final cost function and adding corresponding weights to the external cameras in different locations, an effective joint calibration of multiple devices is constructed. Furthermore, the method is tested in a practical platform, and experiment results show that the proposed joint calibration method can achieve a satisfactory performance in a project real-time system and its accuracy is higher than the manufacturer's calibration.

Simultaneous Calibration: A Joint Optimization Approach for Multiple Kinect and External Cameras

PubMed Central

Liao, Yajie; Sun, Ying; Li, Gongfa; Kong, Jianyi; Jiang, Guozhang; Jiang, Du; Cai, Haibin; Ju, Zhaojie; Yu, Hui; Liu, Honghai

2017-01-01

Camera calibration is a crucial problem in many applications, such as 3D reconstruction, structure from motion, object tracking and face alignment. Numerous methods have been proposed to solve the above problem with good performance in the last few decades. However, few methods are targeted at joint calibration of multi-sensors (more than four devices), which normally is a practical issue in the real-time systems. In this paper, we propose a novel method and a corresponding workflow framework to simultaneously calibrate relative poses of a Kinect and three external cameras. By optimizing the final cost function and adding corresponding weights to the external cameras in different locations, an effective joint calibration of multiple devices is constructed. Furthermore, the method is tested in a practical platform, and experiment results show that the proposed joint calibration method can achieve a satisfactory performance in a project real-time system and its accuracy is higher than the manufacturer’s calibration. PMID:28672823

Microstructure and Mechanical Properties of Laser Welded Joints of DZ125L and IN718 Nickel Base Superalloys

NASA Astrophysics Data System (ADS)

Liang, Taosha; Wang, Lei; Liu, Yang; Song, Xiu

2018-05-01

The microstructure and mechanical properties of the laser welded joint of DZ125L and IN718 nickel base superalloys were investigated. The results show that the fusion zone (FZ) mainly consists of fine dendrite structure with fine γ', Laves phases and MC carbides inhomogeneously distributed. The high welding temperature induces the partial dissolution of γ' in the heat-affected zone (HAZ) of DZ125L and liquation of grain boundaries in both of the HAZs. After post-weld heat treatment (PWHT), fine γ″ and γ' phases precipitate in the FZ, IN718 HAZ and IN718 base metal (BM), and fine γ' precipitate in the γ channel of the HAZ and BM of DZ125L. With tensile testing, the joints after PWHT show higher strengths than that of the weaker DZ125L alloy. Plastic deformation mainly concentrates in the weaker DZ125L and the joint finally fails in the DZ125L BM.

2D joint inversion of CSAMT and magnetic data based on cross-gradient theory

NASA Astrophysics Data System (ADS)

Wang, Kun-Peng; Tan, Han-Dong; Wang, Tao

2017-06-01

A two-dimensional forward and backward algorithm for the controlled-source audio-frequency magnetotelluric (CSAMT) method is developed to invert data in the entire region (near, transition, and far) and deal with the effects of artificial sources. First, a regularization factor is introduced in the 2D magnetic inversion, and the magnetic susceptibility is updated in logarithmic form so that the inversion magnetic susceptibility is always positive. Second, the joint inversion of the CSAMT and magnetic methods is completed with the introduction of the cross gradient. By searching for the weight of the cross-gradient term in the objective function, the mutual influence between two different physical properties at different locations are avoided. Model tests show that the joint inversion based on cross-gradient theory offers better results than the single-method inversion. The 2D forward and inverse algorithm for CSAMT with source can effectively deal with artificial sources and ensures the reliability of the final joint inversion algorithm.

Income-related health transfers principles and orderings of joint distributions of income and health.

PubMed

Khaled, Mohamad A; Makdissi, Paul; Yazbeck, Myra

2018-01-01

The objective of this article is to provide the analyst with the necessary tools that allow for a robust ordering of joint distributions of health and income. We contribute to the literature on the measurement and inference of socioeconomic health inequality in three distinct but complementary ways. First, we provide a formalization of the socioeconomic health inequality-specific ethical principle introduced by Erreygers et al. (2012) . Second, we propose new graphical tools and dominance tests for the identification of robust orderings of joint distributions of income and health associated with this new ethical principle. Finally, based on both pro-poor and pro-extreme ranks ethical principles we address a very important aspect of dominance literature: the inference. To illustrate the empirical relevance of the proposed approach, we compare joint distributions of income and a health-related behavior in the United States in 1997 and 2014. Copyright © 2017 Elsevier B.V. All rights reserved.

Robust Joint Graph Sparse Coding for Unsupervised Spectral Feature Selection.

PubMed

Zhu, Xiaofeng; Li, Xuelong; Zhang, Shichao; Ju, Chunhua; Wu, Xindong

2017-06-01

In this paper, we propose a new unsupervised spectral feature selection model by embedding a graph regularizer into the framework of joint sparse regression for preserving the local structures of data. To do this, we first extract the bases of training data by previous dictionary learning methods and, then, map original data into the basis space to generate their new representations, by proposing a novel joint graph sparse coding (JGSC) model. In JGSC, we first formulate its objective function by simultaneously taking subspace learning and joint sparse regression into account, then, design a new optimization solution to solve the resulting objective function, and further prove the convergence of the proposed solution. Furthermore, we extend JGSC to a robust JGSC (RJGSC) via replacing the least square loss function with a robust loss function, for achieving the same goals and also avoiding the impact of outliers. Finally, experimental results on real data sets showed that both JGSC and RJGSC outperformed the state-of-the-art algorithms in terms of k -nearest neighbor classification performance.

Posttraumatic proximal migration of the first metatarsophalangeal joint sesamoids: a report of four cases.

PubMed

Graves, S C; Prieskorn, D; Mann, R A

1991-10-01

Four cases are presented with plantar plate injury to the first metatarsophalangeal (MTP) joint and proximal retraction of the sesamoids by the flexor hallucis brevis. No history of dislocation occurred in any patient, although two had associated fractures of a sesamoid bone. Clinical and radiographic aids to the diagnosis are discussed. Clinical findings included diffuse pain beneath the first MTP joint and pain with extremes of joint motion in all patients. The anterior-posterior (AP) radiographic technique was the most helpful in determining the proximal migration of the sesamoids. By taking the AP view with both feet on the cassette and by centering the beam perpendicular to it, the diagnosis of plantar plate disruption can easily be made. Initial treatment of this disorder was nonoperative using a stiff soled shoe. With conservative treatment, two of the patients returned to preinjury activities. One patient required sesamoidectomy for resistant pain, and the final patient is still unable to return to his preinjury job requiring standing and heavy lifting.

Ruminant methane reduction through livestock development in Tanzania. Final report for US Department of Energy and US Initiative on Joint Implementation--Activities Implemented Jointly

DOE Office of Scientific and Technical Information (OSTI.GOV)

Livingston, Roderick

1999-07-01

This project was designed to help develop the US Initiative on Joint Implementation activities in Eastern Africa. It has been communicated in meetings with representatives from the Ministry of Environment of Tanzania and the consultant group that developed Tanzania's National Climate Change Action Plan, the Centre for Energy, Environment, Science and Technology, that this project fits very well with the developmental and environmental goals of the Government of Tanzania. The goal of the Activities Implemented Jointly ruminant livestock project is to reduce ruminant methane emissions in Eastern Africa. The project plans a sustainable cattle multiplication unit (CMU) at Mabuki Ranchmore » in the Mwanza Region of Tanzania. This CMU will focus on raising genetically improved animals to be purchased by farmers, developmental organizations, and other CMUs in Tanzania. Through the purchase of these animals farmers will raise their income generation potential and reduce ruminant methane emissions.« less

Students Tackle Academics in Practical Context at Skateboard Factory

ERIC Educational Resources Information Center

Pearson, George

2012-01-01

High school student Nick Robertson came to Oasis Skateboard Factory (OSF) from a suburban Toronto district. He was surfing the web when he spotted a reference to Oasis Skateboard Factory, an alternative program in the Toronto District School Board. He says his first reaction was "Skateboards in school? It didn't seem possible." He…

Muon Accelerator Program (MAP) | Homepage

Science.gov Websites

collider and neutrino factory Scientists around the world are developing the technologies necessary for a factory or a muon collider. Read more: Neutrino factory Muon collider Developing a muon source One of the developing and testing RF cavities and magnets for a muon beamline. The facility allows scientists to test

37. NORTH TO BINS ALONG NORTH WALL OF FACTORY BUILDING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

37. NORTH TO BINS ALONG NORTH WALL OF FACTORY BUILDING WHICH REMAIN FILLED WITH NEW OLD STOCK AND USED PARTS FOR ELI WINDMILLS. THE ROPE AT THE LOWER FOREGROUND WAS USED IN ERECTING WINDMILLS AND TOWERS FOR CUSTOMERS. - Kregel Windmill Company Factory, 1416 Central Avenue, Nebraska City, Otoe County, NE

The first use of a HPLC system at a Louisiana Sugarcane Factory: What it can do for you

USDA-ARS?s Scientific Manuscript database

Alma Plantation sugarcane factory established and operated the first High Performance Liquid Chromatography (HPLC) system in Louisiana in 2015. Although many HPLC systems exist, the factory opted for a ThermoFisherTM ion chromatography (anion exchange) system with integrated pulsed amperometric det...

Factory-Calibrated Continuous Glucose Sensors: The Science Behind the Technology.

PubMed

Hoss, Udo; Budiman, Erwin Satrya

2017-05-01

The use of commercially available continuous glucose monitors for diabetes management requires sensor calibrations, which until recently are exclusively performed by the patient. A new development is the implementation of factory calibration for subcutaneous glucose sensors, which eliminates the need for user calibrations and the associated blood glucose tests. Factory calibration means that the calibration process is part of the sensor manufacturing process and performed under controlled laboratory conditions. The ability to move from a user calibration to factory calibration is based on several technical requirements related to sensor stability and the robustness of the sensor manufacturing process. The main advantages of factory calibration over the conventional user calibration are: (a) more convenience for the user, since no more fingersticks are required for calibration and (b) elimination of use errors related to the execution of the calibration process, which can lead to sensor inaccuracies. The FreeStyle Libre ™ and FreeStyle Libre Pro ™ flash continuous glucose monitoring systems are the first commercially available sensor systems using factory-calibrated sensors. For these sensor systems, no user calibrations are required throughout the sensor wear duration.

Incense and joss stick making in small household factories, Thailand.

PubMed

Siripanich, S; Siriwong, W; Keawrueang, P; Borjan, M; Robson, M

2014-07-01

Incense and joss stick are generally used in the world. Most products were made in small household factories. There are many environmental and occupational hazards in these factories. To evaluate the workplace environmental and occupational hazards in small household incense and joss stick factories in Roi-Et, Thailand. Nine small household factories in rural areas of Roi-Et, Thailand, were studied. Dust concentration and small aerosol particles were counted through real time exposure monitoring. The inductively coupled plasma optical emission spectrometry (ICP-OES) was used for quantitative measurement of heavy metal residue in incense products. Several heavy metals were found in dissolved dye and joss sticks. Those included barium, manganese, and lead. Rolling and shaking processes produced the highest concentration of dust and aerosols. Only 3.9% of female workers used personal protection equipment. Dust and chemicals were major threats in small household incense and joss stick factories in Thailand. Increasing awareness towards using personal protection equipment and emphasis on elimination of environmental workplace hazards should be considered to help the workers of this industry.

Entrepreneurship Education through Industrial Internship for Technical and Vocational Students

NASA Astrophysics Data System (ADS)

Sumual, H.; Soputan, G. J.

2018-02-01

The spirit of entrepreneurship must be formed in an integrated process in learning so that commitment, responsibility and work ethic on the candidate of vocational high school graduates are effectively promoted. Learning teaching factory teaches students how to find problems, build prototypes, learn to make business plan, and learn to present their own solutions. The research objective is to assess the effectiveness of Teaching Factory implementation in improving the competence and skills of students in the field of entrepreneurship. The method used in this research is case study. Key informants were determined purposively in charge of teaching factory, students, and teachers who teach in productive subject. The results achieved in this study are: 1) culinary and hospitality units are the most active groups in producing products for teaching factory, 2) the role of entrepreneurial groups in each unit of production in order to increase productivity 3) students earn revenues of teaching factory and production unit get percentage of product or service sales, 3) the role of each production unit determines the level of teaching factory effectiveness.

Design of Experiments with Multiple Independent Variables: A Resource Management Perspective on Complete and Reduced Factorial Designs

PubMed Central

Collins, Linda M.; Dziak, John J.; Li, Runze

2009-01-01

An investigator who plans to conduct experiments with multiple independent variables must decide whether to use a complete or reduced factorial design. This article advocates a resource management perspective on making this decision, in which the investigator seeks a strategic balance between service to scientific objectives and economy. Considerations in making design decisions include whether research questions are framed as main effects or simple effects; whether and which effects are aliased (confounded) in a particular design; the number of experimental conditions that must be implemented in a particular design and the number of experimental subjects the design requires to maintain the desired level of statistical power; and the costs associated with implementing experimental conditions and obtaining experimental subjects. In this article four design options are compared: complete factorial, individual experiments, single factor, and fractional factorial designs. Complete and fractional factorial designs and single factor designs are generally more economical than conducting individual experiments on each factor. Although relatively unfamiliar to behavioral scientists, fractional factorial designs merit serious consideration because of their economy and versatility. PMID:19719358

Quantum computation with realistic magic-state factories

NASA Astrophysics Data System (ADS)

O'Gorman, Joe; Campbell, Earl T.

2017-03-01

Leading approaches to fault-tolerant quantum computation dedicate a significant portion of the hardware to computational factories that churn out high-fidelity ancillas called magic states. Consequently, efficient and realistic factory design is of paramount importance. Here we present the most detailed resource assessment to date of magic-state factories within a surface code quantum computer, along the way introducing a number of techniques. We show that the block codes of Bravyi and Haah [Phys. Rev. A 86, 052329 (2012), 10.1103/PhysRevA.86.052329] have been systematically undervalued; we track correlated errors both numerically and analytically, providing fidelity estimates without appeal to the union bound. We also introduce a subsystem code realization of these protocols with constant time and low ancilla cost. Additionally, we confirm that magic-state factories have space-time costs that scale as a constant factor of surface code costs. We find that the magic-state factory required for postclassical factoring can be as small as 6.3 million data qubits, ignoring ancilla qubits, assuming 10-4 error gates and the availability of long-range interactions.

Factory-Calibrated Continuous Glucose Sensors: The Science Behind the Technology

PubMed Central

Budiman, Erwin Satrya

2017-01-01

Abstract The use of commercially available continuous glucose monitors for diabetes management requires sensor calibrations, which until recently are exclusively performed by the patient. A new development is the implementation of factory calibration for subcutaneous glucose sensors, which eliminates the need for user calibrations and the associated blood glucose tests. Factory calibration means that the calibration process is part of the sensor manufacturing process and performed under controlled laboratory conditions. The ability to move from a user calibration to factory calibration is based on several technical requirements related to sensor stability and the robustness of the sensor manufacturing process. The main advantages of factory calibration over the conventional user calibration are: (a) more convenience for the user, since no more fingersticks are required for calibration and (b) elimination of use errors related to the execution of the calibration process, which can lead to sensor inaccuracies. The FreeStyle Libre™ and FreeStyle Libre Pro™ flash continuous glucose monitoring systems are the first commercially available sensor systems using factory-calibrated sensors. For these sensor systems, no user calibrations are required throughout the sensor wear duration. PMID:28541139

Cognitive performance deficits in a simulated climb of Mount Everest - Operation Everest II

NASA Technical Reports Server (NTRS)

Kennedy, R. S.; Dunlap, W. P.; Banderet, L. E.; Smith, M. G.; Houston, C. S.

1989-01-01

Cognitive function at simulated altitude was investigated in a repeated-measures within-subject study of performance by seven volunteers in a hypobaric chamber, in which atmospheric pressure was systematically lowered over a period of 40 d to finally reach a pressure equivalent to 8845 m, the approximate height of Mount Everest. The automated performance test system employed compact computer design; automated test administrations, data storage, and retrieval; psychometric properties of stability and reliability; and factorial richness. Significant impairments of cognitive function were seen for three of the five tests in the battery; on two tests, grammatical reasoning and pattern comparison, every subject showed a substantial decrement.

Working fluid selection for space-based two-phase heat transport systems

NASA Technical Reports Server (NTRS)

Mclinden, Mark O.

1988-01-01

The working fluid for externally-mounted, space-based two-phase heat transport systems is considered. A sequence of screening criteria involving freezing and critical point temperatures and latent heat of vaporization and vapor density are applied to a data base of 860 fluids. The thermal performance of the 52 fluids which pass this preliminary screening are then ranked according to their impact on the weight of a reference system. Upon considering other nonthermal criteria (flammability, toxicity, and chemical stability) a final set of 10 preferred fluids is obtained. The effects of variations in system parameters is investigated for these 10 fluids by means of a factorial design.

The Deaf Acculturation Scale (DAS): Development and Validation of a 58-Item Measure

PubMed Central

Maxwell-McCaw, Deborah; Zea, Maria Cecilia

2011-01-01

This study involved the development and validation of the Deaf Acculturation Scale (DAS), a new measure of cultural identity for Deaf and hard-of-hearing (hh) populations. Data for this study were collected online and involved a nation-wide sample of 3,070 deaf/hh individuals. Results indicated strong internal reliabilities for all the subscales, and construct validity was established by demonstrating that the DAS could discriminate groups based on parental hearing status, school background, and use of self-labels. Construct validity was further demonstrated through factorial analyses, and findings resulted in a final 58-item measure. Directions for future research are discussed. PMID:21263041

Locality constrained joint dynamic sparse representation for local matching based face recognition.

PubMed

Wang, Jianzhong; Yi, Yugen; Zhou, Wei; Shi, Yanjiao; Qi, Miao; Zhang, Ming; Zhang, Baoxue; Kong, Jun

2014-01-01

Recently, Sparse Representation-based Classification (SRC) has attracted a lot of attention for its applications to various tasks, especially in biometric techniques such as face recognition. However, factors such as lighting, expression, pose and disguise variations in face images will decrease the performances of SRC and most other face recognition techniques. In order to overcome these limitations, we propose a robust face recognition method named Locality Constrained Joint Dynamic Sparse Representation-based Classification (LCJDSRC) in this paper. In our method, a face image is first partitioned into several smaller sub-images. Then, these sub-images are sparsely represented using the proposed locality constrained joint dynamic sparse representation algorithm. Finally, the representation results for all sub-images are aggregated to obtain the final recognition result. Compared with other algorithms which process each sub-image of a face image independently, the proposed algorithm regards the local matching-based face recognition as a multi-task learning problem. Thus, the latent relationships among the sub-images from the same face image are taken into account. Meanwhile, the locality information of the data is also considered in our algorithm. We evaluate our algorithm by comparing it with other state-of-the-art approaches. Extensive experiments on four benchmark face databases (ORL, Extended YaleB, AR and LFW) demonstrate the effectiveness of LCJDSRC.

Elemental source attribution signatures for calcium ammonium nitrate (CAN) fertilizers used in homemade explosives

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fraga, Carlos G.; Mitroshkov, Alexander V.; Mirjankar, Nikhil S.

Calcium ammonium nitrate (CAN) is a widely available fertilizer composed of ammonium nitrate mixed with some form of calcium carbonate such as limestone or dolomite. CAN is also frequently used to make homemade explosives. The potential of using elemental profiling and chemometrics to match both pristine and reprocessed CAN fertilizers to their factories for use in future forensic investigations was examined. Inductively coupled plasma-mass spectrometry (ICP-MS) analysis was performed on 64 elements in 125 samples from 11 CAN stocks from 6 different CAN factories. Fisher ratio, degree-of-class-separation, and partial least squares discriminant analysis (PLSDA) were used to develop a modelmore » using the concentrations of Na, V, Mn, Cu, Ga, Sr, Ba and U to classify a validation set of CAN samples into 5 factory groups; one group was two factories from the same fertilizer company. In terms of the pristine CAN samples, i.e., unadulterated prills, 64% of the test samples were matched to their correct factory group with zero false positives. The same PLSDA model was used to correctly match 100% of the CAN samples that were reprocessed by crushing and mixing the CAN with powdered sugar. In the case of crushed CAN samples mixed with aluminum powder, correct matches were made for zero to 100% of the samples depending on the factory the CAN originated. Remarkably, for one factory, 100% of the ammonium nitrate samples that were extracted from CAN using tap or bottled water were matched to the correct CAN factory group. Lastly, the water-insoluble (calcium carbonate) portions of CAN provided a greater degree of discrimination between factories than the water-soluble portions of CAN. In summary, this work illustrates that sourcing unadulterated CAN fertilizer can potentially be done with high frequency and high confidence using elemental profiling and chemometrics while the sourcing of reprocessed CAN is dependent on how much an adulterant alters the recovered elemental profile of CAN.« less

[Analysis of musculoskeletal disorders, work load and working postures among manufacturing workers].

PubMed

Yu, Shan-fa; Gu, Gui-zhen; Sun, Shi-yi; Wang, Hai-sheng; Cui, Shou-ming; Yang, Xiao-fa; Yang, Shu-le; He, Li-hua; Wang, Sheng

2011-03-01

To analyze the distribution of the musculoskeletal disorders, work load and working postures in different factories, gender, education levels, age and working years among manufacturing workers. In a cross-sectional study of 5134 manufacturing workers in 12 factories, the morbidities for musculoskeletal disorders in one year period were measured with questionnaires. The morbidities for musculoskeletal disorders in body sites: waist, neck, shoulder, wrist, ankle/feet, knee, hip/buttocks and elbows were 59.7%, 47.9%, 38.1%, 33.7%, 26.9%, 25.4%, 15.2%, and 14.9%, respectively in one year period. There were significant differences of morbidities for musculoskeletal symptoms in body sites of workers among different factories (P < 0.05 or P < 0.01). The morbidities of musculoskeletal symptoms in elbows, waist, wrists and ankle/feet of the workers in refractory material and chemical fiber factories were higher than those in other factories, the morbidities for musculoskeletal symptoms of workers in garments and diamond factories were lower than those in other factories. The morbidities for musculoskeletal symptoms in neck, shoulders and wrists of female workers were significantly higher than those of male workers (P < 0.01). There were significant differences of the morbidities for musculoskeletal symptoms in body sites among workers with different educational levels (P < 0.05 or P < 0.01). There were significant differences of the morbidities for musculoskeletal symptoms in neck, shoulders, wrists, hip/buttocks and knee among groups with different age or different working years (P < 0.01), and the morbidities for musculoskeletal symptoms increased with age and working years. The proportions of unhealthy working postures and high working load among workers in refractory material and chemical fiber factories were higher; but those in garments and diamond factories were lower. The morbidities for musculoskeletal symptoms in waist, neck, shoulder and wrists of workers in manufacturing workers were higher; the gender, education level, age and working years could influenced the morbidities for musculoskeletal disorders.

Presence of sourdough lactic acid bacteria in commercial total mixed ration silage as revealed by denaturing gradient gel electrophoresis analysis.

PubMed

Wang, C; Nishino, N

2010-10-01

To characterize the bacterial communities in commercial total mixed ration (TMR) silage, which is known to have a long bunk life after silo opening. Samples were collected from four factories that produce TMR silage according to their own recipes. Three factories were sampled three times at 1-month intervals during the summer to characterize the differences between factories; one factory was sampled 12 times, three samples each during the summer, autumn, winter and spring, to determine seasonal changes. Bacterial communities were determined by culture-independent denaturing gradient gel electrophoresis. All silages contained lactic acid as the predominant acid, and the contents appeared stable regardless of factories and product seasons. Acetic acid and 1-propanol contents were different between factories and indicated seasonal changes, with increases in warm seasons compared to cool seasons. Both differences and similarities existed among the bacterial communities from each factory and product season. Lactobacillus parabuchneri was found in the products from three of four factories. Various sourdough lactic acid bacteria (LAB) were identified in commercial TMR silage; Lactobacillus panis, Lactobacillus hammesii, Lactobacillus mindensis, Lactobacillus pontis, Lactobacillus frumenti and Lactobacillus farciminis were detected in many products. Moreover, changes owing to product season were distinctive, and Lact. pontis and Lact. frumenti became detectable in summer products. Sourdough LAB are involved in the ensiling of commercial TMR silage. Silage bacterial communities vary more by season than by factory. The LAB species Lact. parabuchneri was detected in the TMR silage but may not be essential to the product's long bunk life after silo opening. Commercial TMR silage resembles sourdough with respect to bacterial communities and long shelf life. The roles of sourdough LAB in the ensiling process and aerobic stability are worth examining. © 2010 The Authors. Journal compilation © 2010 The Society for Applied Microbiology.

A Hospital Is Not Just a Factory, but a Complex Adaptive System-Implications for Perioperative Care.

PubMed

Mahajan, Aman; Islam, Salim D; Schwartz, Michael J; Cannesson, Maxime

2017-07-01

Many methods used to improve hospital and perioperative services productivity and quality of care have assumed that the hospital is essentially a factory, and therefore, that industrial engineering and manufacturing-derived redesign approaches such as Six Sigma and Lean can be applied to hospitals and perioperative services just as they have been applied in factories. However, a hospital is not merely a factory but also a complex adaptive system (CAS). The hospital CAS has many subsystems, with perioperative care being an important one for which concepts of factory redesign are frequently advocated. In this article, we argue that applying only factory approaches such as lean methodologies or process standardization to complex systems such as perioperative care could account for difficulties and/or failures in improving performance in care delivery. Within perioperative services, only noncomplex/low-variance surgical episodes are amenable to manufacturing-based redesign. On the other hand, complex surgery/high-variance cases and preoperative segmentation (the process of distinguishing between normal and complex cases) can be viewed as CAS-like. These systems tend to self-organize, often resist or react unpredictably to attempts at control, and therefore require application of CAS principles to modify system behavior. We describe 2 examples of perioperative redesign to illustrate the concepts outlined above. These examples present complementary and contrasting cases from 2 leading delivery systems. The Mayo Clinic example illustrates the application of manufacturing-based redesign principles to a factory-like (high-volume, low-risk, and mature practice) clinical program, while the Kaiser Permanente example illustrates the application of both manufacturing-based and self-organization-based approaches to programs and processes that are not factory-like but CAS-like. In this article, we describe how factory-like processes and CAS can coexist within a hospital and how self-organization-based approaches can be used to improve care delivery in many situations where manufacturing-based approaches may not be appropriate.

Effects of fatiguing treadmill running on sensorimotor control in athletes with and without functional ankle instability.

PubMed

Steib, Simon; Hentschke, Christian; Welsch, Goetz; Pfeifer, Klaus; Zech, Astrid

2013-08-01

Sensorimotor control is permanently impaired following functional ankle instability and temporarily decreased following fatigue. Little is known on potential interactions between both conditions. The purpose was to investigate the effect of fatiguing exercise on sensorimotor control in athletes with and without (coper, controls) functional ankle instability. 19 individuals with functional ankle instability, 19 ankle sprain copers, and 19 non-injured controls participated in this cohort study. Maximum reach distance in the star excursion balance test, unilateral jump landing stabilization time, center of pressure sway velocity in single-leg-stance, and passive ankle joint position sense were assessed before and immediately after fatiguing treadmill running. A three factorial linear mixed model was specified for each outcome to evaluate the effects of group, exhausting exercise (fatigue) and their interactions (group by fatigue). Effect sizes were calculated as Cohen's d. Maximum reach distance in the star excursion balance test, jump stabilization time and sway velocity, but not joint position sense, were negatively affected by fatigue in all groups. Effect sizes were moderate, ranging from 0.27 to 0.68. No significant group by fatigue interactions were found except for one measure. Copers showed significantly larger prefatigue to postfatigue reductions in anterior reach direction (P≤0.001; d=-0.55) compared to the ankle instability (P=0.007) and control group (P=0.052). Fatiguing exercise negatively affected postural control but not proprioception. Ankle status did not appear to have an effect on fatigue-induced sensorimotor control impairments. © 2013.

Flight motor set 360T004 (STS-30R). Volume 1: System overview

NASA Technical Reports Server (NTRS)

Ricks, Glenn A.

1989-01-01

The fourth NASA space shuttle flight incorporating redesigned solid rocket motors began on 4 May 1989. The flight motors were designated 360Q004A (left-hand) and 360H004B (right-hand); the mission was designated STS-30R. Overall engine performance was excellent. The low sample rate data that was available showed exceptional propulsion performance. All ballistic and mass property parameters closely matched the predicted values and were well within the required contract end item specification levels that could be assessed. No strain, vibration, or aft skirt heating environments could be addressed due to developmental flight instrumentation deletion. Infrared readings from the shuttle thermal imager were considered very good when compared with ground environment instrumentation readings taken during both the aborted and the actual countdowns. However, hand-held infrared gun reading/ground environment instrumentation comparisons were considered poor during both countdowns, with the exception of the T - 3 hour timeframe during the actual launch. Postflight inspection again verified superior performance of the insulation, phenolics, metal parts, and seals. All combustion gas was contained by the insulation in the field and case-to-nozzle joints. Inadequate parachute performance on the left-hand booster caused high splashdown loads, which resulted in a displaced nozzle and factory joint weatherseal unbond anomalies. Recommendations were made concerning improved thermal modeling and instruments. The rationale for these recommendations, the dispositions of all anomalies, and complete result details are given.

Growth factor effects on costal chondrocytes for tissue engineering fibrocartilage

PubMed Central

Johns, D.E.; Athanasiou, K.A.

2010-01-01

Tissue engineered fibrocartilage could become a feasible option for replacing tissues like the knee meniscus or temporomandibular joint disc. This study employed five growth factors insulin-like growth factor-I, transforming growth factor-β1, epidermal growth factor, platelet-derived growth factor-BB, and basic fibroblast growth factor in a scaffoldless approach with costal chondrocytes, attempting to improve biochemical and mechanical properties of engineered constructs. Samples were quantitatively assessed for total collagen, glycosaminoglycans, collagen type I, collagen type II, cells, compressive properties, and tensile properties at two time points. Most treated constructs were worse than the no growth factor control, suggesting a detrimental effect, but the IGF treatment tended to improve the constructs. Additionally, the 6wk time point was consistently better than 3wks, with total collagen, glycosaminoglycans, and aggregate modulus doubling during this time. Further optimization of the time in culture and exogenous stimuli will be important in making a more functional replacement tissue. PMID:18597118

Optimization and analysis of large chemical kinetic mechanisms using the solution mapping method - Combustion of methane

NASA Technical Reports Server (NTRS)

Frenklach, Michael; Wang, Hai; Rabinowitz, Martin J.

1992-01-01

A method of systematic optimization, solution mapping, as applied to a large-scale dynamic model is presented. The basis of the technique is parameterization of model responses in terms of model parameters by simple algebraic expressions. These expressions are obtained by computer experiments arranged in a factorial design. The developed parameterized responses are then used in a joint multiparameter multidata-set optimization. A brief review of the mathematical background of the technique is given. The concept of active parameters is discussed. The technique is applied to determine an optimum set of parameters for a methane combustion mechanism. Five independent responses - comprising ignition delay times, pre-ignition methyl radical concentration profiles, and laminar premixed flame velocities - were optimized with respect to thirteen reaction rate parameters. The numerical predictions of the optimized model are compared to those computed with several recent literature mechanisms. The utility of the solution mapping technique in situations where the optimum is not unique is also demonstrated.

Welding, Bonding and Fastening, 1984

NASA Technical Reports Server (NTRS)

Buckley, J. D. (Editor); Stein, B. A. (Editor)

1985-01-01

A compilation of papers presented in a joint NASA, American Society for Metals, The George Washington University, American Welding Soceity, and Society of Manufacturing Engineers conference on Welding, Bonding, and Fastening at Langley Research Center, Hampton, VA, on October 23 to 25, 1984 is given. Papers were presented on technology developed in current research programs relevant to welding, bonding, and fastening of structural materials required in fabricating structures and mechanical systems used in the aerospace, hydrospace, and automotive industries. Topics covered in the conference included equipment, hardware and materials used when welding, brazing, and soldering, mechanical fastening, explosive welding, use of unique selected joining techniques, adhesives bonding, and nondestructive evaluation. A concept of the factory of the future was presented, followed by advanced welding techniques, automated equipment for welding, welding in a cryogenic atmosphere, blind fastening, stress corrosion resistant fasteners, fastening equipment, explosive welding of different configurations and materials, solid-state bonding, electron beam welding, new adhesives, effects of cryogenics on adhesives, and new techniques and equipment for adhesive bonding.

Effect of Isothermal Aging and Thermal Cycling on Interfacial IMC Growth and Fracture Behavior of SnAgCu/Cu Joints

NASA Astrophysics Data System (ADS)

Li, Xiaoyan; Li, Fenghui; Guo, Fu; Shi, Yaowu

2011-01-01

The growth behavior of interfacial intermetallic compounds (IMCs) of SnAgCu/Cu soldered joints was investigated during the reflow process, isothermal aging, and thermal cycling with a focus on the influence of these parameters on growth kinetics. The SnAgCu/Cu soldered joints were isothermally aged at 125°C, 150°C, and 175°C while the thermal cycling was performed within the temperature ranges from -25°C to 125°C and -40°C to 125°C. It was observed that a Cu6Sn5 layer formed, followed by rapid coarsening at the solder/Cu interface during reflowing. The grain size of the interfacial Cu6Sn5 was found to increase with aging time, and the morphology evolved from scallop-like to needle-like to rod-like and finally to particles. The rod-like Ag3Sn phase was formed on the solder side in front of the previously formed Cu6Sn5 layer. However, when subject to an increase of the aging time, the Cu3Sn phase was formed at the interface of the Cu6Sn5 layer and Cu substrate. The IMC growth rate increased with aging temperature for isothermally aged joints. During thermal cycling, the thickness of the IMC layer was found to increase with the number of thermal cycles, although the growth rate was slower than that for isothermal aging. The dwell time at the high-temperature end of the thermal cycles was found to significantly influence the growth rate of the IMCs. The growth of the IMCs, for both isothermal aging and thermal cycling, was found to be Arrhenius with aging temperature, and the corresponding diffusion factor and activation energy were obtained by data fitting. The tensile strength of the soldered joints decreased with increasing aging time. Consequently, the fracture site of the soldered joints migrated from the solder matrix to the interfacial Cu6Sn5 layer. Finally, the shear strength of the joints was found to decrease with both an increase in the number of thermal cycles and a decrease in the dwell temperature at the low end of the thermal cycle.

Ohio Route 50 joint sealant experiment.

DOT National Transportation Integrated Search

2002-03-01

This is the third and Final Report for a research project that entailed the construction and evaluation to date of a stretch of a four-lane highway near Athens, Ohio. The main purpose of this project has been to evaluate concrete pavement performance...

Needs, barriers, and analysis methods for integrated urban freight transportation : final report.

DOT National Transportation Integrated Search

2015-08-01

In this joint project University of Maryland, West Virginia University, and Morgan State University worked together to : solve critical problems associated with urban freight systems. A review of literature and case studies on freight : villages and ...

Jointless bridges : final report.

DOT National Transportation Integrated Search

1981-01-01

The results of this study are reported in two parts. The first deals with the various methods states are employing to reduce the number of joints in bridge decks. The most common method is the use of integral abutments, where the superstructure is jo...

Burnout Factories: The Challenge of Retaining Great Teachers in Charter Schools

ERIC Educational Resources Information Center

Fusco, Mark

2017-01-01

In its well-intentioned effort to create alternatives to public school dropout factories, the charter school sector has created teacher burnout factories. But it does not have to be this way. Charter schools can continue to maintain high standards while creating a more sustainable work environment for teachers. This article examines the teacher…

Poor but Not Powerless: Women Workers in Production Chain Factories in China

ERIC Educational Resources Information Center

Ma, Lang; Jacobs, Francine

2010-01-01

The present study demonstrates the processes by which 12 young women working in four production chain factories in China shape their own lives--their developmental trajectories--during the period following their entry into factory work. One-on-one, in-depth, semi-structured interviews were conducted in August, 2005, as part of an evaluation…

Factorial Validity and Invariance Testing of the Exercise Dependence Scale-Revised in Swedish and Portuguese Exercisers

ERIC Educational Resources Information Center

Lindwall, Magnus; Palmeira, Antonio

2009-01-01

The present study investigated the factorial validity and factorial invariance of the 21-item Exercise Dependence Scale-Revised using 162 Swedish and 269 Portuguese exercisers. In addition, the prevalence of exercise dependence symptoms and links to exercise behavior, gender, and age in the two samples was also studied. Confirmatory factor…

19 CFR Appendix B to Part 191 - Sample Formats for Applications for Specific Manufacturing Drawback Rulings

Code of Federal Regulations, 2010 CFR

2010-04-01

... (see § 191.8(a)).) LOCATION OF FACTORY (Give the address of the factory(s) where the process of... article described under the PROCESS OF MANUFACTURE OR PRODUCTION section below and each article listed... manufacture or production by giving a thorough description of the manufacturing process. This description...