Research on aspheric focusing lens processing and testing technology in the high-energy laser test system

NASA Astrophysics Data System (ADS)

Liu, Dan; Fu, Xiu-hua; Jia, Zong-he; Wang, Zhe; Dong, Huan

2014-08-01

In the high-energy laser test system, surface profile and finish of the optical element are put forward higher request. Taking a focusing aspherical zerodur lens with a diameter of 100mm as example, using CNC and classical machining method of combining surface profile and surface quality of the lens were investigated. Taking profilometer and high power microscope measurement results as a guide, by testing and simulation analysis, process parameters were improved constantly in the process of manufacturing. Mid and high frequency error were trimmed and improved so that the surface form gradually converged to the required accuracy. The experimental results show that the final accuracy of the surface is less than 0.5μm and the surface finish is □, which fulfils the accuracy requirement of aspherical focusing lens in optical system.

Increasing Paramedic Students' Resiliency to Stress: Assessing Correlates and the Impact of Intervention

ERIC Educational Resources Information Center

Porter, Shirley; Johnson, Andrew

2008-01-01

This pilot study focused on paramedic students in the final year of their college program. Using a randomised controlled pre-test/post-test design, this study sought to determine whether perceived peer support, negative attitude towards emotional expression, and specific coping processes, would be significantly predictive of levels of…

Thai-Alberta Co-Operative Assessment Project Concerning Thirty-Two Rural Secondary Schools in the Third National Economic and Social Plan, Thailand (1972-1976). Final Report.

ERIC Educational Resources Information Center

Chareonchai, Ruang; And Others

This extensive assessment project report focuses on the Rural Secondary Schools (RSS) Project in Thailand. The background, design, rationale and objectives of the assessment are described, as are the eight phases of the study: reconnaissance; proposals; basic planning and pre-testing; data collection; analysis; academic review; final report; and…

Superstrong Adjustable Permanent Magnet for a Linear Collider Final Focus

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mihara, T.

A superstrong permanent magnet quadrupole (PMQ) is one of the candidates for the final focus lens for the linear collider because of its compactness and low power consumption. The first fabricated prototype of our PMQ achieved a 300T/m superstrong field gradient with a 100mm overall magnet radius and a 7mm bore radius, but a drawback is its fixed strength. Therefore, a second prototype of PMQ, whose strength is adjustable, was fabricated. Its strength adjustability is based on the ''double ring structure'', rotating subdivided magnet slices separately. This second prototype is being tested. Some of the early results are presented.

EPIC : expedited processing at international crossings : evaluation final report

DOT National Transportation Integrated Search

1998-09-01

This executive summary presents an overview of the Expedited Processing at International Crossings (EPIC) Field Operational Test (FOT). The EPIC focus was on the commercial vehicle transport component of international border crossings at the Nogales,...

The Three-Fingers Technique: Does It Reduce Test Anxiety?

ERIC Educational Resources Information Center

Maycock, George

The utility of brief exposure to a mental focusing aid, the Three-Fingers Technique (TFT), in reducing test anxiety was studied for 15 college students. One week before their final examination, the students were given a 15-minute classroom introduction to the TFT, part of the Silva Mental Training Method (1983). After the introduction to this…

Trajectory measurements and correlations in the final focus beam line at the KEK Accelerator Test Facility

NASA Astrophysics Data System (ADS)

Renier, Y.; Bambade, P.; Tauchi, T.; White, G. R.; Boogert, S.

2013-06-01

The Accelerator Test Facility 2 (ATF2) commissioning group aims to demonstrate the feasibility of the beam delivery system of the next linear colliders (ILC and CLIC) as well as to define and to test the tuning methods. As the design vertical beam sizes of the linear colliders are about few nanometers, the stability of the trajectory as well as the control of the aberrations are very critical. ATF2 commissioning started in December 2008, and thanks to submicron resolution beam position monitors (BPMs), it has been possible to measure the beam position fluctuation along the final focus of ATF2 during the 2009 runs. The optics was not the nominal one yet, with a lower focusing to make the tuning easier. In this paper, a method to measure the noise of each BPM every pulse, in a model-independent way, will be presented. A method to reconstruct the trajectory’s fluctuations is developed which uses the previously determined BPM resolution. As this reconstruction provides a measurement of the beam energy fluctuations, it was also possible to measure the horizontal and vertical dispersion function at each BPMs parasitically. The spatial and angular dispersions can be fitted from these measurements with uncertainties comparable with usual measurements.

Integrating transit and urban form : final report, December 2008.

DOT National Transportation Integrated Search

2008-09-01

This study develops an integrated behavioral model of transit patronage and urban form. Although herein focused on transit, the framework can be easily generalized to study other forms of travel. Advanced econometric methods are used to test specific...

Advantage I-75 mainline automated clearance system : final evaluation report

DOT National Transportation Integrated Search

1998-08-01

The focus of this evaluation was to determine if the Advantage I-75 Mainline Automated Clearance Systems (MACS) produced significant fuel savings for motor carriers. The fundamental hypothesis tested was that the reduction or elimination of stops at ...

Final report : mobile surveillance and wireless communication systems field operational test. Volume 1, Executive summary

DOT National Transportation Integrated Search

1999-03-01

This study focused on assessing the application of traffic monitoring and management systems which use transportable surveillance and ramp meter trailers, video image processors, and wireless communications. The mobile surveillance and wireless commu...

A Fire Safety Certification System for Board and Care Operators and Staff. SBIR Phase II: Final Report.

ERIC Educational Resources Information Center

Walker, Bonnie L.

This report describes Phase II of a project which developed a system for delivering fire safety training to board and care providers who serve adults with developmental disabilities. Phase II focused on developing and pilot testing a "train the trainers" workshop for instructors and field testing the provider's workshop. Evaluation of…

Design and Field Testing of a Systematic Procedure for Evaluating Vocational Programs. Final Report.

ERIC Educational Resources Information Center

Portland Public Schools, OR.

The purpose of a project was to design and field-test a system for evaluating the adequacy of the vocational curriculum utilized by the Vocational Village, an alternative school for the training of individuals who have experienced failure in other educational settings. Focus was on the development of an evaluation model which will assess the…

Changes in Student Populations and Average Test Scores of Dutch Primary Schools

ERIC Educational Resources Information Center

Luyten, Hans; de Wolf, Inge

2011-01-01

This article focuses on the relation between student population characteristics and average test scores per school in the final grade of primary education from a dynamic perspective. Aggregated data of over 5,000 Dutch primary schools covering a 6-year period were used to study the relation between changes in school populations and shifts in mean…

R&D status of linear collider technology at KEK

NASA Astrophysics Data System (ADS)

Urakawa, Junji

1992-02-01

This paper gives an outline of the Japan Linear Collider (JLC) project, especially JLC-I. The status of the various R&D works is particularly presented for the following topics: (1) electron and positron sources, (2) S-band injector linacs, (3) damping rings, (4) high power klystrons and accelerating structures, (5) the final focus system. Finally, the status of the construction and design studies for the Accelerator Test Facility (ATF) is summarized.

Development of interactive hypermedia software for high school biology: A research and development study

NASA Astrophysics Data System (ADS)

Alturki, Uthman T.

The goal of this research was to research, design, and develop a hypertext program for students who study biology. The Ecology Hypertext Program was developed using Research and Development (R&D) methodology. The purpose of this study was to place the final "product", a CD-ROM for learning biology concepts, in the hands of teachers and students to help them in learning and teaching process. The product was created through a cycle of literature review, needs assessment, development, and a cycle of field tests and revisions. I applied the ten steps of R&D process suggested by Borg and Gall (1989) which, consisted of: (1) Literature review, (2) Needs assessment, (3) Planning, (4) Develop preliminary product, (5) Preliminary field-testing, (6) Preliminary revision, (7) Main field-testing, (8) Main revision, (9) Final field-testing, and (10) Final product revision. The literature review and needs assessment provided a support and foundation for designing the preliminary product---the Ecology Hypertext Program. Participants in the needs assessment joined a focus group discussion. They were a group of graduate students in education who suggested the importance for designing this product. For the preliminary field test, the participants were a group of high school students studying biology. They were the potential user of the product. They reviewed the preliminary product and then filled out a questionnaire. Their feedback and suggestions were used to develop and improve the product in a step called preliminary revision. The second round of field tasting was the main field test in which the participants joined a focus group discussion. They were the same group who participated in needs assessment task. They reviewed the revised product and then provided ideas and suggestions to improve the product. Their feedback were categorized and implemented to develop the product as in the main revision task. Finally, a group of science teachers participated in this study by reviewing the product and then filling out the questionnaire. Their suggestions were used to conduct the final step in R&D methodology, the final product revision. The primary result of this study was the Ecology Hypertext Program. It considered a small attempt to give students an opportunity to learn through an interactive hypertext program. In addition, using the R&D methodology was an ideal procedure for designing and developing new educational products and material.

Development and Engineering Design in Support of "Rover Ranch": A K-12 Outreach Software Project

NASA Technical Reports Server (NTRS)

Pascali, Raresh

2003-01-01

A continuation of the initial development started in the summer of 1999, the body of work performed in support of 'ROVer Ranch' Project during the present fellowship dealt with the concrete concept implementation and resolution of the related issues. The original work performed last summer focused on the initial examination and articulation of the concept treatment strategy, audience and market analysis for the learning technologies software. The presented work focused on finalizing the set of parts to be made available for building an AERCam Sprint type robot and on defining, testing and implementing process necessary to convert the design engineering files to VRML files. Through reverse engineering, an initial set of mission critical systems was designed for beta testing in schools. The files were created in ProEngineer, exported to VRML 1.0 and converted to VRML 97 (VRML 2.0) for final integration in the software. Attributes for each part were assigned using an in-house developed JAVA based program. The final set of attributes for each system, their mutual interaction and the identification of the relevant ones to be tracked, still remain to be decided.

Emotional Intelligence and Interpersonal Relations.

ERIC Educational Resources Information Center

Schutte, Nicola S.; Malouff, John M.; Bobik, Chad; Coston, Tracie D.; Greeson, Cyndy; Jedlicka, Christina; Rhodes, Emily; Wendorf, Greta

2001-01-01

Presents the results of seven studies that focused on the link between emotional intelligence and interpersonal relations. Tests emotional intelligence with empathy and self-monitoring, social skills, cooperation, relations with others, and marital satisfaction. Explores preference for emotionally intelligent partners in the final study. Includes…

Radiation tests on optical fibres: good and bad practice

NASA Astrophysics Data System (ADS)

Kuhnhenn, J.

2017-11-01

Testing optical fibers for their response to ionizing radiation is unavoidable if their properties in radiation environments need to be known. So far, no model exists that would be able to predict the behavior of optical fibers in the presence of radiation, for example because too many, mostly unknown parameters influence the changes in the fiber. To obtain reliable results from irradiation tests of optical fibers a well-defined setup and thorough experience is needed to avoid erroneous data that might lead to wrong decisions for the final application. This presentation tries to introduce basic concepts of radiation testing of optical fibers, focusing on not so well known influences or typical errors. Focus will be laid on the measurement of radiation-induced attenuation (RIA) in optical fibers.

HANFORD MEDIUM-LOW CURIE WASTE PRETREATMENT ALTERNATIVES PROJECT FRACTIONAL CRYSTALLIZATION PILOT SCALE TESTING FINAL REPORT

DOE Office of Scientific and Technical Information (OSTI.GOV)

HERTING DL

2008-09-16

The Fractional Crystallization Pilot Plant was designed and constructed to demonstrate that fractional crystallization is a viable way to separate the high-level and low-activity radioactive waste streams from retrieved Hanford single-shell tank saltcake. The focus of this report is to review the design, construction, and testing details of the fractional crystallization pilot plant not previously disseminated.

Institutional Support for Peer Contact in Distance Education: An Empirical Investigation.

ERIC Educational Resources Information Center

Amundsen, Cheryl Lynn; Bernard, Robert M.

1989-01-01

Discussion of interpersonal communication in distance education focuses on a study conducted at the Institute of Canadian Bankers based on Keegan's theoretical framework of re-integrating interpersonal components through learning materials. Hypotheses tested are explained, and achievement, self-perception of learning achievement, final academic…

Technical summary : Travtek operational test evaluation : final reports

DOT National Transportation Integrated Search

2009-01-01

This guide is packed with useful information. It focuses on some of the less well-known safety messages the road offers you. It is designed to be kept in your glove compartment after it has been read so that you will have its valuable information at ...

Beach Point Test Site, Aberdeen Proving Ground, Edgewood Area, Maryland. Focused Feasibility Study, Final Project Work Plan

DTIC Science & Technology

1993-10-01

Disposal Act (SWDA)/Resource Conservation and Recovery Act (RCRA). Jacobs Englnwfng Gmo Inc FINAL PROJECT WORK PLAN Washington Operatvo 8~ Fs 2-551I Date...shaded map of contaminated areas defined by chemical data, more than one map may be consructed f special and grapk cons *tft ame encountered. Results...that a Siophysical c ao p Pro rma down the axis or Beah PointS using geophysic teehnozoglosts that are •vi subsurface hyd&rosAdgraphic cmal beneath

Testing the parton evolution with the use of two-body final states

NASA Astrophysics Data System (ADS)

Baranov, S. P.; Jung, H.; Lipatov, A. V.; Malyshev, M. A.

2017-01-01

We consider the production of b{bar{b}} quarks and Drell-Yan lepton pairs under LHC conditions focusing attention on the total transverse momentum of the produced pair and on the azimuthal angle between the momenta of the outgoing particles. Plotting the corresponding distributions in bins of the final-state invariant mass, one can reconstruct the full map of the transverse momentum dependent parton densities in a proton. We give examples of how these distributions can look like at the LHC energies.

Prototype development and demonstration for response, emergency staging, communications, uniform management, and evacuation (R.E.S.C.U.M.E.) : technical report on prototype development and field testing of R.E.S.C.U.M.E. applications.

DOT National Transportation Integrated Search

2015-04-01

This document is the final project technical report for the development and field testing of the Response, Emergency Staging, Communications, Uniform Management, and Evacuation (R.E.S.C.U.M.E.) application bundle, with a focus on the Incident Zone (I...

Idea Project Final Report, A Sequential Hypothesis Testing-Based Decision-Making System For Freeway Incident Response

DOT National Transportation Integrated Search

1995-10-01

THIS INVESTIGATION WAS COMPLETED AS PART OF THE ITS-IDEA PROGRAM WHICH IS ONE OF THREE IDEA PROGRAMS MANAGED BY THE TRANSPORTATION RESEARCH BOARD (TRB) TO FOSTER INNOVATIONS IN SURFACE TRANSPORTATION. IT FOCUSES ON PRODUCTS AND RESULT FOR THE DEVELOP...

SUPERFUND TREATABILITY CLEARINGHOUSE: FINAL REPORT: DEVELOPMENT OF OPTIMUM TREATMENT SYSTEM FOR WASTEWATER LAGOONS PHASE II - SOLVENT EXTRACTION LABORATORY TESTING

EPA Science Inventory

The U.S. Army surveyed innovative treatment techniques for restoration of hazardous waste lagoons and selected solvent extraction as cost-effective restoration for further study. This treatability study focuses on treatment of organic (explosive) contaminated lagoon sediments w...

Idea Project Final Report, Engineered Visibility Warning Signals: Tests Of Time To React, Detectability, Identifiability And Salience

DOT National Transportation Integrated Search

1996-05-01

THIS INVESTIGATION WAS COMPLETED AS PART OF THE ITS-IDEA PROGRAM WHICH IS ONE OF THREE IDEA PROGRAMS MANAGED BY THE TRANSPORTATION RESEARCH BOARD (TRB) TO FOSTER INNOVATIONS IN SURFACE TRANSPORTATION. IT FOCUSES ON PRODUCTS AND RESULT FOR THE DEVELOP...

Personal Accountability in Education: Measure Development and Validation

ERIC Educational Resources Information Center

Rosenblatt, Zehava

2017-01-01

Purpose: The purpose of this paper, three-study research project, is to establish and validate a two-dimensional scale to measure teachers' and school administrators' accountability disposition. Design/methodology/approach: The scale items were developed in focus groups, and the final measure was tested on various samples of Israeli teachers and…

Demographic Faultlines: A Meta-Analysis of the Literature

ERIC Educational Resources Information Center

Thatcher, Sherry M. B.; Patel, Pankaj C.

2011-01-01

We propose and test a theoretical model focusing on antecedents and consequences of demographic faultlines. We also posit contingencies that affect overall team dynamics in the context of demographic faultlines, such as the study setting and performance measurement. Using meta-analysis structural equation modeling with a final data set consisting…

Final report on testing of TOPAZ II unit Ya-21u: Output power characteristics and system capabilities

NASA Astrophysics Data System (ADS)

Luchau, David W.; Sinkevich, Valery G.; Wernsman, Bernard; Mulder, Daniel M.

1996-03-01

A final report on the output power characteristics and capabilities of the TOPAZ II Space Nuclear Power Unit Ya-21u is presented. Results showed that after a total of almost 8,000 hours of system testing in the U.S. and Russia, several emergency cooldowns, and three inadvertent air introductions to the interelectrode gap (IEG) that the TOPAZ II demonstrates the potential for providing reliable power in a space environment. Output power optimizations and system characteristics following a shock and vibration test are shown. These tests were performed using electrical heaters that simulate nuclear fuel heating. This paper will focus primarily on the changes in output power characteristics over the lifetime of Ya-21u. All U.S. testing was conducted at the Thermionic System Evaluation Test (TSET) Facility of the New Mexico Engineering Research Institute (NMERI) as a part of the TOPAZ International Program (TIP). TIP is managed by the Air Force Phillips Laboratory (PL) for the Ballistic Missile Defense Organization (BMDO).

Focus stacking: Comparing commercial top-end set-ups with a semi-automatic low budget approach. A possible solution for mass digitization of type specimens

PubMed Central

Brecko, Jonathan; Mathys, Aurore; Dekoninck, Wouter; Leponce, Maurice; VandenSpiegel, Didier; Semal, Patrick

2014-01-01

Abstract In this manuscript we present a focus stacking system, composed of commercial photographic equipment. The system is inexpensive compared to high-end commercial focus stacking solutions. We tested this system and compared the results with several different software packages (CombineZP, Auto-Montage, Helicon Focus and Zerene Stacker). We tested our final stacked picture with a picture obtained from two high-end focus stacking solutions: a Leica MZ16A with DFC500 and a Leica Z6APO with DFC290. Zerene Stacker and Helicon Focus both provided satisfactory results. However, Zerene Stacker gives the user more possibilities in terms of control of the software, batch processing and retouching. The outcome of the test on high-end solutions demonstrates that our approach performs better in several ways. The resolution of the tested extended focus pictures is much higher than those from the Leica systems. The flash lighting inside the Ikea closet creates an evenly illuminated picture, without struggling with filters, diffusers, etc. The largest benefit is the price of the set-up which is approximately € 3,000, which is 8 and 10 times less than the LeicaZ6APO and LeicaMZ16A set-up respectively. Overall, this enables institutions to purchase multiple solutions or to start digitising the type collection on a large scale even with a small budget. PMID:25589866

Focus stacking: Comparing commercial top-end set-ups with a semi-automatic low budget approach. A possible solution for mass digitization of type specimens.

PubMed

Brecko, Jonathan; Mathys, Aurore; Dekoninck, Wouter; Leponce, Maurice; VandenSpiegel, Didier; Semal, Patrick

2014-01-01

In this manuscript we present a focus stacking system, composed of commercial photographic equipment. The system is inexpensive compared to high-end commercial focus stacking solutions. We tested this system and compared the results with several different software packages (CombineZP, Auto-Montage, Helicon Focus and Zerene Stacker). We tested our final stacked picture with a picture obtained from two high-end focus stacking solutions: a Leica MZ16A with DFC500 and a Leica Z6APO with DFC290. Zerene Stacker and Helicon Focus both provided satisfactory results. However, Zerene Stacker gives the user more possibilities in terms of control of the software, batch processing and retouching. The outcome of the test on high-end solutions demonstrates that our approach performs better in several ways. The resolution of the tested extended focus pictures is much higher than those from the Leica systems. The flash lighting inside the Ikea closet creates an evenly illuminated picture, without struggling with filters, diffusers, etc. The largest benefit is the price of the set-up which is approximately € 3,000, which is 8 and 10 times less than the LeicaZ6APO and LeicaMZ16A set-up respectively. Overall, this enables institutions to purchase multiple solutions or to start digitising the type collection on a large scale even with a small budget.

Dual-Tree Complex Wavelet Transform and Image Block Residual-Based Multi-Focus Image Fusion in Visual Sensor Networks

PubMed Central

Yang, Yong; Tong, Song; Huang, Shuying; Lin, Pan

2014-01-01

This paper presents a novel framework for the fusion of multi-focus images explicitly designed for visual sensor network (VSN) environments. Multi-scale based fusion methods can often obtain fused images with good visual effect. However, because of the defects of the fusion rules, it is almost impossible to completely avoid the loss of useful information in the thus obtained fused images. The proposed fusion scheme can be divided into two processes: initial fusion and final fusion. The initial fusion is based on a dual-tree complex wavelet transform (DTCWT). The Sum-Modified-Laplacian (SML)-based visual contrast and SML are employed to fuse the low- and high-frequency coefficients, respectively, and an initial composited image is obtained. In the final fusion process, the image block residuals technique and consistency verification are used to detect the focusing areas and then a decision map is obtained. The map is used to guide how to achieve the final fused image. The performance of the proposed method was extensively tested on a number of multi-focus images, including no-referenced images, referenced images, and images with different noise levels. The experimental results clearly indicate that the proposed method outperformed various state-of-the-art fusion methods, in terms of both subjective and objective evaluations, and is more suitable for VSNs. PMID:25587878

Dual-tree complex wavelet transform and image block residual-based multi-focus image fusion in visual sensor networks.

PubMed

Yang, Yong; Tong, Song; Huang, Shuying; Lin, Pan

2014-11-26

This paper presents a novel framework for the fusion of multi-focus images explicitly designed for visual sensor network (VSN) environments. Multi-scale based fusion methods can often obtain fused images with good visual effect. However, because of the defects of the fusion rules, it is almost impossible to completely avoid the loss of useful information in the thus obtained fused images. The proposed fusion scheme can be divided into two processes: initial fusion and final fusion. The initial fusion is based on a dual-tree complex wavelet transform (DTCWT). The Sum-Modified-Laplacian (SML)-based visual contrast and SML are employed to fuse the low- and high-frequency coefficients, respectively, and an initial composited image is obtained. In the final fusion process, the image block residuals technique and consistency verification are used to detect the focusing areas and then a decision map is obtained. The map is used to guide how to achieve the final fused image. The performance of the proposed method was extensively tested on a number of multi-focus images, including no-referenced images, referenced images, and images with different noise levels. The experimental results clearly indicate that the proposed method outperformed various state-of-the-art fusion methods, in terms of both subjective and objective evaluations, and is more suitable for VSNs.

The design principles of axilla deodorant fragrances.

PubMed

McGee, T; Rankin, K M; Baydar, A

1998-11-30

There are a number of ways that deodorant products control malodor: a) by suppressing sweat, b) by inhibiting bacterial activity, and c) by covering malodor. The paper focuses on the Givaudan Roure methodology used to develop fragrances that effectively cover malodor. Several steps are involved in the development of a successful deodorant fragrance. First, we test for substantivity of the deodorant fragrance material in the axilla, using odor value technology. Second, using an in vitro test with reconstituted axilla odor, we determine the effectiveness of the substantive fragrance material with carefully screened panelists. Third, using a multichannel olfactive blender, the perfumer creates a fragrance heart with effective deodorant fragrance materials that cover malodor in the vapor phase. Finally, the hedonically pleasing heart is used to create the final fragrance, which is then optimized using our in vitro test method.

Assessing Student Understanding in and between Courses in Chemistry

ERIC Educational Resources Information Center

Claesgens, Jennifer; Scalise, Kathleen; Wilson, Mark; Stacy, Angelica

2008-01-01

When the final report of Secretary of Education Margaret Spelling's Commission on the Future of Higher Education was released in September 2006, the call for higher education to focus on measuring and reporting "meaningful student learning outcomes" was a major charge. The report's suggestion that some standardized tests might be used to collect…

ISSOE Student Guidance and Development of Personalized Occupational Education Programs. Findings and Recommendations, Final Report.

ERIC Educational Resources Information Center

Beuke, Vernon; Frank, Robert

The Instructional Support System for Occupational Education (ISSOE) project focused on (1) review of individualized education systems, (2) selection of appropriate occupational clusters, and (3) development and field testing of a system and materials. Exemplary and innovative approaches to individualized education were reviewed by site visits and…

78 FR 35909 - Endocrine Disruptor Screening Program; Final Policies and Procedures for Screening Safe Drinking...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-14

... obtained from the testing to the Administrator, within a reasonable time period that the [Agency... market and should instead focus on obtaining data from companies that might be expected to contribute to... identifying and assessing the contributions of past participants. However, if EPA is unable to obtain...

Integrated Science in the Seychelles: An Evaluation.

ERIC Educational Resources Information Center

Brophy, Michael; Pillay, Patrick

1986-01-01

Provides an overview of the educational program of the Seychelles and focuses on an evaluation of the final phase (P7-P9) of the nine-year school program. Reports how findings from content analyses of materials, teacher and student interviews, and student test results were used to develop the new Seychelles Integrated Science program. (ML)

How decision reversibility affects motivation.

PubMed

Bullens, Lottie; van Harreveld, Frenk; Förster, Jens; Higgins, Tory E

2014-04-01

The present research examined how decision reversibility can affect motivation. On the basis of extant findings, it was suggested that 1 way it could affect motivation would be to strengthen different regulatory foci, with reversible decision making, compared to irreversible decision making, strengthening prevention-related motivation relatively more than promotion-related motivation. If so, then decision reversibility should have effects associated with the relative differences between prevention and promotion motivation. In 5 studies, we manipulated the reversibility of a decision and used different indicators of regulatory focus motivation to test these predictions. Specifically, Study 1 tested for differences in participants' preference for approach versus avoidance strategies toward a desired end state. In Study 2, we used speed and accuracy performance as indicators of participants' regulatory motivation, and in Study 3, we measured global versus local reaction time performance. In Study 4, we approached the research question in a different way, making use of the value-from-fit hypothesis (Higgins, 2000, 2002). We tested whether a fit between chronic regulatory focus and focus induced by the reversibility of the decision increased participants' subjective positive feelings about the decision outcome. Finally, in Study 5, we tested whether regulatory motivation, induced by decision reversibility, also influenced participants' preference in specific product features. The results generally support our hypothesis showing that, compared to irreversible decisions, reversible decisions strengthen a prevention focus more than a promotion focus. Implications for research on decision making are discussed.

The Multidimensional Assessment of Interoceptive Awareness (MAIA)

PubMed Central

Mehling, Wolf E.; Price, Cynthia; Daubenmier, Jennifer J.; Acree, Mike; Bartmess, Elizabeth; Stewart, Anita

2012-01-01

This paper describes the development of a multidimensional self-report measure of interoceptive body awareness. The systematic mixed-methods process involved reviewing the current literature, specifying a multidimensional conceptual framework, evaluating prior instruments, developing items, and analyzing focus group responses to scale items by instructors and patients of body awareness-enhancing therapies. Following refinement by cognitive testing, items were field-tested in students and instructors of mind-body approaches. Final item selection was achieved by submitting the field test data to an iterative process using multiple validation methods, including exploratory cluster and confirmatory factor analyses, comparison between known groups, and correlations with established measures of related constructs. The resulting 32-item multidimensional instrument assesses eight concepts. The psychometric properties of these final scales suggest that the Multidimensional Assessment of Interoceptive Awareness (MAIA) may serve as a starting point for research and further collaborative refinement. PMID:23133619

FINAL DESIGN REVIEW REPORT Subcritical Experiments Gen 2, 3-ft Confinement Vessel Weldment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Romero, Christopher

A Final Design Review (FDR) of the Subcritical Experiments (SCE) Gen 2, 3-ft. Confinement Vessel Weldment was held at Los Alamos National Laboratory (LANL) on September 14, 2017. The review was a focused review on changes only to the confinement vessel weldment (versus a system design review). The changes resulted from lessons-learned in fabricating and inspecting the current set of confinement vessels used for the SCE Program. The baseline 3-ft. confinement vessel weldment design has successfully been used (to date) for three (3) high explosive (HE) over-tests, two (2) fragment tests, and five (5) integral HE experiments. The design teammore » applied lessons learned from fabrication and inspection of these vessel weldments to enhance fit-up, weldability, inspection, and fitness for service evaluations. The review team consisted of five (5) independent subject matter experts with engineering design, analysis, testing, fabrication, and inspection experience. The« less

Visual Aids and Multimedia in Second Language Acquisition

ERIC Educational Resources Information Center

Halwani, Noha

2017-01-01

Education involves more than simply passing the final test. Rather, it is the process of educating an entire generation. This research project focused on language learners of English as a Second Language. This action research was conducted in an ESL classroom in H. Frank Carey High School, one of five high schools in the Sewanhaka Central District…

Continuing Education for Electrical Power Technicians. Final Report, June 1976-December 1978.

ERIC Educational Resources Information Center

Tinnell, Richard W., Ed.

The objective of this project was to develop and test a method of offering technical education to individuals employed in the electrical power industry. Representatives from industry were invited to an advisory council meeting where attention was focused on the needs of the industry. This information was used to define an extensive curriculum, and…

Idle minds are the devil's tools? Coping, depressed mood and divergent thinking in older adults.

PubMed

Mélendez, Juan Carlos; Alfonso-Benlliure, Vicente; Mayordomo, Teresa

2017-10-20

The main aim was to test a causal relations model of the problem-focused and emotion-focused coping styles, depressed mood, and divergent thinking (DT) in older adults. It was hypothesized that both forms of coping would have a significant effect on predicting depressed mood, and that problem-focused coping and depressed mood would have a significant effect on DT. Participants were 135 subjects with ages ranging between 55 and 84 years old, who took part in a personal interview and filled out several questionnaires. The statistical analysis included structural equations models (SEM). The initial model led to a final model endorsed by the goodness of fit, composite reliability, and discriminant validity indexes. This model confirms a direct relationship between the two types of coping strategies and depressed mood (with the opposite sign), but not between rational coping and DT. Finally, depressed mood was also confirmed as a mediator variable between coping and DT. The type of coping is a clear predictor of mood in older adults. Advanced age decline is not necessarily translated into inefficacy in everyday problem solving especially in those who, through proble-focused coping, avoid depressed moods and maintain good levels of DT.

Development of Micro Air Vehicle Technology With In-Flight Adaptive-Wing Structure

NASA Technical Reports Server (NTRS)

Waszak, Martin R. (Technical Monitor); Shkarayev, Sergey; Null, William; Wagner, Matthew

2004-01-01

This is a final report on the research studies, "Development of Micro Air Vehicle Technology with In-Flight Adaptrive-Wing Structure". This project involved the development of variable-camber technology to achieve efficient design of micro air vehicles. Specifically, it focused on the following topics: 1) Low Reynolds number wind tunnel testing of cambered-plate wings. 2) Theoretical performance analysis of micro air vehicles. 3) Design of a variable-camber MAV actuated by micro servos. 4) Test flights of a variable-camber MAV.

Phase I Final Scientific Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lu, Xijia; Fetvedt, Jeremy; Dimmig, Walker

This Final Scientific Report addresses the accomplishments achieved during Phase I of DE- FE0023985, Coal Syngas Combustor Development for Supercritical CO 2 Power Cycles. The primary objective of the project was to develop a coal syngas-fueled combustor design for use with high-pressure, high-temperature, oxy-fuel, supercritical CO 2 power cycles, with particular focus given to the conditions required by the Allam Cycle. The primary goals, from the Statement of Project Objectives, were to develop: (1) a conceptual design of a syngas-fueled combustor-turbine block for a 300MWe high-pressure, oxy-fuel, sCO2 power plant; (2) the preliminary design of a 5MWt test combustor; andmore » (3) the definition of a combustor test program. Accomplishments for each of these goals are discussed in this report.« less

Carryover negligibility and relevance in bioequivalence studies.

PubMed

Ocaña, Jordi; Sanchez O, Maria P; Carrasco, Josep L

2015-01-01

The carryover effect is a recurring issue in the pharmaceutical field. It may strongly influence the final outcome of an average bioequivalence study. Testing a null hypothesis of zero carryover is useless: not rejecting it does not guarantee the non-existence of carryover, and rejecting it is not informative of the true degree of carryover and its influence on the validity of the final outcome of the bioequivalence study. We propose a more consistent approach: even if some carryover is present, is it enough to seriously distort the study conclusions or is it negligible? This is the central aim of this paper, which focuses on average bioequivalence studies based on 2 × 2 crossover designs and on the main problem associated with carryover: type I error inflation. We propose an equivalence testing approach to these questions and suggest reasonable negligibility or relevance limits for carryover. Finally, we illustrate this approach on some real datasets. Copyright © 2015 John Wiley & Sons, Ltd.

Creating the final conversations scale: a measure of end-of-life relational communication with terminally ill individuals.

PubMed

Generous, Mark Alan; Keeley, Maureen P

2014-01-01

Final conversations (FCs) are defined as the communicative interactions, both verbal and nonverbal, that occur between terminally ill patients and relational partners. In this study, the "Final Conversations Scale" was developed and tested. A total of 152 participants that had engaged in final conversations with individuals that were terminally ill completed the newly developed instrument. Factor analysis produced a five-factor structure, including: messages of spirituality/religion; expressions of love; proactive difficult relationship talk; everyday communication; and talk about illness/death. Participants' perceptions of the relational closeness and difficulty with the deceased significantly influenced the individuals' recalled frequency of FCs messages. Practical and scholarly implications focus on the needs of the family members regarding their communication with terminally ill individuals, as well as directions for future research with the FCs Scale.

Development of a spiritually based educational program to increase colorectal cancer screening among African American men and women.

PubMed

Holt, Cheryl L; Roberts, Chastity; Scarinci, Isabel; Wiley, Shereta R; Eloubeidi, Mohamad; Crowther, Martha; Bolland, John; Litaker, Mark S; Southward, Vivian; Coughlin, Steven S

2009-07-01

This study describes the development of a spiritually based intervention to increase colorectal cancer screening through African American churches by framing the health message with spiritual themes and scripture. The intervention development phase consisted of ideas from an advisory panel and core content identified in focus groups. In the pilot-testing phase, prototypes of the intervention materials were tested for graphic appeal in additional focus groups, and content was tested for acceptability and comprehension in cognitive interviews. Participants preferred materials showing a variety of African Americans in real settings, bright color schemes, and an uplifting message emphasizing prevention and early detection. Spiritual themes such as stewardship over the body, being well to serve God, and using faith to overcome fear, were well received. The materials were then finalized for implementation and will be used by community health advisors to encourage screening.

Final Report: High Energy Physics at the Energy Frontier at Louisiana Tech

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sawyer, Lee; Wobisch, Markus; Greenwood, Zeno D.

The Louisiana Tech University High Energy Physics group has developed a research program aimed at experimentally testing the Standard Model of particle physics and searching for new phenomena through a focused set of analyses in collaboration with the ATLAS experiment at the Large Hadron Collider (LHC) at the CERN laboratory in Geneva. This research program includes involvement in the current operation and maintenance of the ATLAS experiment and full involvement in Phase 1 and Phase 2 upgrades in preparation for future high luminosity (HL-LHC) operation of the LHC. Our focus is solely on the ATLAS experiment at the LHC, withmore » some related detector development and software efforts. We have established important service roles on ATLAS in five major areas: Triggers, especially jet triggers; Data Quality monitoring; grid computing; GPU applications for upgrades; and radiation testing for upgrades. Our physics research is focused on multijet measurements and top quark physics in final states containing tau leptons, which we propose to extend into related searches for new phenomena. Focusing on closely related topics in the jet and top analyses and coordinating these analyses in our group has led to high efficiency and increased visibility inside the ATLAS collaboration and beyond. Based on our work in the DØ experiment in Run II of the Fermilab Tevatron Collider, Louisiana Tech has developed a reputation as one of the leading institutions pursuing jet physics studies. Currently we are applying this expertise to the ATLAS experiment, with several multijet analyses in progress.« less

Three-Dimensional User Interfaces for Immersive Virtual Reality

NASA Technical Reports Server (NTRS)

vanDam, Andries

1997-01-01

The focus of this grant was to experiment with novel user interfaces for immersive Virtual Reality (VR) systems, and thus to advance the state of the art of user interface technology for this domain. Our primary test application was a scientific visualization application for viewing Computational Fluid Dynamics (CFD) datasets. This technology has been transferred to NASA via periodic status reports and papers relating to this grant that have been published in conference proceedings. This final report summarizes the research completed over the past year, and extends last year's final report of the first three years of the grant.

A Superstrong Adjustable Permanent Magnet for the Final Focus Quadrupole in a Linear Collider

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mihara, T.

A super strong permanent magnet quadrupole (PMQ) was fabricated and tested. It has an integrated strength of 28.5T with overall length of 10 cm and a 7mm bore radius. The final focus quadrupole of a linear collider needs a variable focal length. This can be obtained by slicing the magnet into pieces along the beamline direction and rotating these slices. But this technique may lead to movement of the magnetic center and introduction of a skew quadrupole component when the strength is varied. A ''double ring structure'' can ease these effects. A second prototype PMQ, containing thermal compensation materials andmore » with a double ring structure, has been fabricated. Worm gear is selected as the mechanical rotating scheme because the double ring structure needs a large torque to rotate magnets. The structure of the second prototype PMQ is shown.« less

Development Testing and Subsequent Failure Investigation of a Spring Strut Mechanism

NASA Technical Reports Server (NTRS)

Dervan, Jared; Robertson, Brandan; Staab, Lucas; Culberson, Michael; Pellicciotti, Joseph

2014-01-01

The NASA Engineering and Safety Center (NESC) and Lockheed Martin (LM) performed random vibration testing on a single spring strut development unit to assess its ability to withstand qualification level random vibration environments. Failure of the strut while exposed to random vibration resulted in a follow-on failure investigation, design changes, and additional development tests. This paper focuses on the results of the failure investigations referenced in detail in the NESC final report [1] including identified lessons learned to aid in future design iterations of the spring strut and to help other mechanism developers avoid similar pitfalls.

Development Testing and Subsequent Failure Investigation of a Spring Strut Mechanism

NASA Technical Reports Server (NTRS)

Dervan, Jared; Robertson, Brandon; Staab, Lucas; Culberson, Michael; Pellicciotti, Joseph

2014-01-01

The NASA Engineering and Safety Center (NESC) and Lockheed Martin (LM) performed random vibration testing on a single spring strut development unit to assess its ability to withstand qualification level random vibration environments. Failure of the strut while exposed to random vibration resulted in a follow-on failure investigation, design changes, and additional development tests. This paper focuses on the results of the failure investigations referenced in detail in the NESC final report including identified lessons learned to aid in future design iterations of the spring strut and to help other mechanism developers avoid similar pitfalls.

A Research Study To Determine the Effects of PSAT Verbal Skills Training on Secondary Students.

ERIC Educational Resources Information Center

Reichenberger, Marcella

The primary focus of this experiment was to determine the effects of verbal skill training for the Preliminary Scholastic Aptitude Test (PSAT) on secondary school students. The other concern was whether there was a correlation between class grades and PSAT scores. Finally, there was a determination as to whether there were any attitude changes…

78 FR 72074 - Decision and Order Granting a Waiver to Felix Storch, Inc. (FSI) From the Department of Energy...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-02

... industrial equipment, which includes commercial refrigeration equipment, the focus of this notice.\\1\\ Part C... for commercial refrigeration equipment. (42 U.S.C. 6314(a)(6)(C)) On December 8, 2006, DOE published a final rule adopting test procedures for commercial refrigeration equipment. 71 FR 71340. Title 10 of the...

External High School Diploma Program Evaluation Project. Final Report, October 1, 1979-June 30, 1980. Part III: Competency Comparison.

ERIC Educational Resources Information Center

Hole, Wanda Clements; Seggerson, Sharon Corcoran

The purpose of this portion of a project was to compare External High School Diploma (EHSDP) competencies at Waukesha County (Wisconsin) Technical Institute with minimum high school competency requirements in (1) local school districts and (2) selected states. Testing focused on basic skills of mathematics, reading, and writing. Minimum competency…

Focused Feedback With Video Tape As An Aid In Counseling Underachieving College Freshmen. Final Report.

ERIC Educational Resources Information Center

Valine, Warren J.

This study examines the relative effectiveness of 3 group counseling techniques and a control group in counseling with underachieving college freshmen. The effectiveness of each method was determined through comparison of grade point averages (GPA) as well as by pre- and post-test scores on selected self concept variables of the Tennessee Self…

Genetic counselors’ (GC) knowledge, awareness, and understanding of clinical next-generation sequencing (NGS) genomic testing

PubMed Central

Boland, PM; Ruth, K; Matro, JM; Rainey, KL; Fang, CY; Wong, YN; Daly, MB; Hall, MJ

2014-01-01

Genomic tests are increasingly complex, less expensive, and more widely available with the advent of next-generation sequencing (NGS). We assessed knowledge and perceptions among genetic counselors pertaining to NGS genomic testing via an online survey. Associations between selected characteristics and perceptions were examined. Recent education on NGS testing was common, but practical experience limited. Perceived understanding of clinical NGS was modest, specifically concerning tumor testing. Greater perceived understanding of clinical NGS testing correlated with more time spent in cancer-related counseling, exposure to NGS testing, and NGS-focused education. Substantial disagreement about the role of counseling for tumor-based testing was seen. Finally, a majority of counselors agreed with the need for more education about clinical NGS testing, supporting this approach to optimizing implementation. PMID:25523111

Reading, readability, and legibility research: implications for notification letters.

PubMed

Zimmerman, D E

1993-01-01

This article defines communication science and then briefly describes three research areas relevant to worker notifications: (1) receiving of notification messages, (2) reading and understanding of notification messages, and (3) influences or effects of notification messages on workers. Next, the article focuses on the reading and legibility research relevant to worker notifications and then provides 16 guidelines for drafting worker notifications. Finally, the article suggests evaluating draft notifications by using one or more of the following: skilled editorial reviews, readability scoring, Cloze techniques, signal stopping techniques, in-depth personal interviews, focus groups, and usability testing.

Concept Area Three Objectives and Test Items (Rev.). Part One and Part Two. Economic Analysis Course. Segments 50 - 84.

ERIC Educational Resources Information Center

Sterling Inst., Washington, DC. Educational Technology Center.

A multimedia course in economic analysis was developed and used in conjunction with the United States Naval Academy. (See ED 043 790 and ED 043 791 for final reports of the project evaluation and development model.) This report deals with concept area three of the course, which focuses on microeconomics. The behavioral objectives, hierarchy…

Concept Area Four and Five Objectives, Hierarchy Charts, and Test Items. Economic Analysis Course. Segments 85-96.

ERIC Educational Resources Information Center

Sterling Inst., Washington, DC. Educational Technology Center.

A multimedia course in economic analysis was developed and used in conjunction with the United States Naval Academy. (See ED 043 790 and ED 043 791 for final reports of the project evaluation and development model.) This report deals with concept areas four and five, which focus on international trade and enrichment areas. The behavioral…

Design of the micro pressure multi-node measuring system for micro-fluidic chip

NASA Astrophysics Data System (ADS)

Mu, Lili; Guo, Shuheng; Rong, Li; Yin, Ke

2016-01-01

An online multi-node microfludic pressure measuring system was designed in the paper. The research focused on the design of pressure test circuit system and methods on dealing with pressure data collecting. The MPXV7002 micro-pressure sensor was selected to measure the chip inside channel pressure and installed by a silicone tube on different micro-channel measured nodes. The pressure transmission loss was estimated in the paper, and corrected by the filtering and smoothing method. The pressure test experiment was carried out and the data were analyzed. Finally, the measuring system was calibrated. The results showed that the measuring system had high testing precision.

Nonlinear and progressive failure aspects of transport composite fuselage damage tolerance

NASA Technical Reports Server (NTRS)

Walker, Tom; Ilcewicz, L.; Murphy, Dan; Dopker, Bernhard

1993-01-01

The purpose is to provide an end-user's perspective on the state of the art in life prediction and failure analysis by focusing on subsonic transport fuselage issues being addressed in the NASA/Boeing Advanced Technology Composite Aircraft Structure (ATCAS) contract and a related task-order contract. First, some discrepancies between the ATCAS tension-fracture test database and classical prediction methods is discussed, followed by an overview of material modeling work aimed at explaining some of these discrepancies. Finally, analysis efforts associated with a pressure-box test fixture are addressed, as an illustration of modeling complexities required to model and interpret tests.

A demonstration test of the dual-beam polarimetry differential imaging system for the high-contrast observation

NASA Astrophysics Data System (ADS)

Dou, Jiangpei; Ren, Deqing; Zhu, Yongtian; Wang, Xue; Zhang, Xi; Li, Rong

2012-09-01

We propose a dual-beam polarimetry differential imaging test system that can be used for the direct imaging of the exoplanets. The system is composed of a liquid crystal variable retarder (LCVR) in the pupil to switch between two orthogonal polarized states, and a Wollaston prism (WP) that will be inserted before the final focal focus of the system to create two polarized images for the differential subtraction. Such a system can work separately or be integrated in the coronagraph system to enhance the high-contrast imaging. To demonstrate the feasibility of the proposed system, here we show the initial test result both with and without integrating our developed coronagraph. A unique feature for this system is that each channel can subtract with itself by using the retarder to rotate the planet's polarization orientation, which has the best performance according to our lab test results. Finally, it is shown that the polarimetry differential imaging system is a promising technique and can be used for the direct imaging observation of reflected lights from the exoplanets.

Determination of rate of customer focus in educational programs at Isfahan University of Medical Sciences(1) based on students' viewpoints.

PubMed

Shams, Assadollah; Yarmohammadian, Mohammad Hosein; Abbarik, Hadi Hayati

2012-01-01

Today, the challenges of quality improvement and customer focus as well as systems development are important and inevitable matters in higher education institutes. There are some highly competitive challenges among educational institutes, including accountability to social needs, increasing costs of education, diversity in educational methods and centers and their consequent increasing competition, and the need for adaptation of new information and knowledge to focus on students as the main customers. Hence, the purpose of this study was to determine the rate of costumer focus based on Isfahan University of Medical Sciences students' viewpoints and to suggest solutions to improve this rate. This was a cross-sectional study carried out in 2011. The statistical population included all the students of seven faculties of Isfahan University of Medical Sciences. According to statistical formulae, the sample size consisted of 384 subjects. Data collection tools included researcher-made questionnaire whose reliability was found to be 87% by Cronbach's alpha coefficient. Finally, using the SPSS statistical software and statistical methods of independent t-test and one-way analysis of variance (ANOVA), Likert scale based data were analyzed. The mean of overall score for customer focus (student-centered) of Isfahan University of Medical Sciences was 46.54. Finally, there was a relation between the mean of overall score for customer focus and gender, educational levels, and students' faculties. Researcher suggest more investigation between Medical University and others. It is a difference between medical sciences universities and others regarding the customer focus area, since students' gender must be considered as an effective factor in giving healthcare services quality. In order to improve the customer focus, it is essential to take facilities, field of study, faculties, and syllabus into consideration.

Determination of rate of customer focus in educational programs at Isfahan University of Medical Sciences1 based on students’ viewpoints

PubMed Central

Shams, Assadollah; Yarmohammadian, Mohammad Hosein; Abbarik, Hadi Hayati

2012-01-01

Background: Today, the challenges of quality improvement and customer focus as well as systems development are important and inevitable matters in higher education institutes. There are some highly competitive challenges among educational institutes, including accountability to social needs, increasing costs of education, diversity in educational methods and centers and their consequent increasing competition, and the need for adaptation of new information and knowledge to focus on students as the main customers. Hence, the purpose of this study was to determine the rate of costumer focus based on Isfahan University of Medical Sciences students’ viewpoints and to suggest solutions to improve this rate. Materials and Methods: This was a cross-sectional study carried out in 2011. The statistical population included all the students of seven faculties of Isfahan University of Medical Sciences. According to statistical formulae, the sample size consisted of 384 subjects. Data collection tools included researcher-made questionnaire whose reliability was found to be 87% by Cronbach's alpha coefficient. Finally, using the SPSS statistical software and statistical methods of independent t-test and one-way analysis of variance (ANOVA), Likert scale based data were analyzed. Results: The mean of overall score for customer focus (student-centered) of Isfahan University of Medical Sciences was 46.54. Finally, there was a relation between the mean of overall score for customer focus and gender, educational levels, and students’ faculties. Researcher suggest more investigation between Medical University and others. Conclusion: It is a difference between medical sciences universities and others regarding the customer focus area, since students’ gender must be considered as an effective factor in giving healthcare services quality. In order to improve the customer focus, it is essential to take facilities, field of study, faculties, and syllabus into consideration. PMID:23555127

Training Program for Cardiology Residents to Perform Focused Cardiac Ultrasound Examination with Portable Device.

PubMed

Siqueira, Vicente N; Mancuso, Frederico J N; Campos, Orlando; De Paola, Angelo A; Carvalho, Antonio C; Moises, Valdir A

2015-10-01

Training requirements for general cardiologists without echocardiographic expertise to perform focused cardiac ultrasound (FCU) with portable devices have not yet been defined. The objective of this study was to evaluate a training program to instruct cardiology residents to perform FCU with a hand-carried device (HCD) in different clinical settings. Twelve cardiology residents were subjected to a 50-question test, 4 lectures on basic echocardiography and imaging interpretation, the supervised interpretation of 50 echocardiograms and performance of 30 exams using HCD. After this period, they repeated the written test and were administered a practical test comprising 30 exams each (360 patients) in different clinical settings. They reported on 15 parameters and a final diagnosis; their findings were compared to the HCD exam of a specialist in echocardiography. The proportion of correct answers on the theoretical test was higher after training (86%) than before (51%; P = 0.001). The agreement was substantial among the 15 parameters analyzed (kappa ranging from 0.615 to 0.891; P < 0.001). The percentage of correct interpretation was lower for abnormal (75%) than normal (95%) items, for valve abnormalities (85%) compared to other items (92%) and for graded scale (87%) than for dichotomous (95%) items (P < 0.0001, for all). For the final diagnoses, the kappa value was higher than 0.941 (P < 0.001; 95% CI [0.914, 0.955]). The training proposed enabled residents to perform FCU with HCD, and their findings were in good agreement with those of a cardiologist specialized in echocardiography. © 2015, Wiley Periodicals, Inc.

Overview of the NASA Subsonic Rotary Wing Aeronautics Research Program in Rotorcraft Crashworthiness

NASA Technical Reports Server (NTRS)

Jackson, Karen E.; Kellas, Sotiris; Fuchs, Yvonne T.

2009-01-01

This paper provides an overview of rotorcraft crashworthiness research being conducted at NASA Langley Research Center under sponsorship of the Subsonic Rotary Wing (SRW) Aeronautics Program. The research is focused in two areas: development of an externally deployable energy attenuating concept and improved prediction of rotorcraft crashworthiness. The deployable energy absorber (DEA) is a composite honeycomb structure, with a unique flexible hinge design that allows the honeycomb to be packaged and remain flat until needed for deployment. The capabilities of the DEA have been demonstrated through component crush tests and vertical drop tests of a retrofitted fuselage section onto different surfaces or terrain. The research on improved prediction of rotorcraft crashworthiness is focused in several areas including simulating occupant responses and injury risk assessment, predicting multi-terrain impact, and utilizing probabilistic analysis methods. A final task is to perform a system-integrated simulation of a full-scale helicopter crash test onto a rigid surface. A brief description of each research task is provided along with a summary of recent accomplishments.

Overview of the NASA Subsonic Rotary Wing Aeronautics Research Program in Rotorcraft Crashworthiness

NASA Technical Reports Server (NTRS)

Jackson, Karen E.; Fuchs, Yvonne T.; Kellas, Sotiris

2008-01-01

This paper provides an overview of rotorcraft crashworthiness research being conducted at NASA Langley Research Center under sponsorship of the Subsonic Rotary Wing (SRW) Aeronautics Program. The research is focused in two areas: development of an externally deployable energy attenuating concept and improved prediction of rotorcraft crashworthiness. The deployable energy absorber (DEA) is a composite honeycomb structure, with a unique flexible hinge design that allows the honeycomb to be packaged and remain flat until needed for deployment. The capabilities of the DEA have been demonstrated through component crush tests and vertical drop tests of a retrofitted fuselage section onto different surfaces or terrain. The research on improved prediction of rotorcraft crashworthiness is focused in several areas including simulating occupant responses and injury risk assessment, predicting multi-terrain impact, and utilizing probabilistic analysis methods. A final task is to perform a system-integrated simulation of a full-scale helicopter crash test onto a rigid surface. A brief description of each research task is provided along with a summary of recent accomplishments.

A protocol to evaluate drug-related workplace impairment.

PubMed

Reisfield, Gary M; Shults, Theodore; Demery, Jason; Dupont, Robert

2013-03-01

The dramatic increase in the use and abuse of prescription controlled substances, cannabis, and a rapidly evolving array of legal and illegal psychotropic drugs has led to a growing concern by employers about workplace impairment, incidents, and accidents. The Federal Workplace Drug Testing Programs, which serve as a template for most private sector programs, focus on a small group of illicit drugs, but disregard the wider spectrum of legal and illegal psychotropic drugs and prescription controlled substances. We propose a protocol for the evaluation of workplace impairment, based on comprehensive drug and alcohol testing at the time of suspected impairment, followed expeditiously by a comprehensive physician evaluation, including a focused medical history with an emphasis on controlled substance use, physical and mental status examinations, evaluation of employee adherence to prescription medication instructions, additional drug testing if indicated, use of collateral sources of information, and querying of state prescription monitoring databases. Finally, we propose suggestions for optimizing the evaluation of drug-related workplace impairment.

Mitigating chromatic effects for the transverse focusing of intense charged particle beams

NASA Astrophysics Data System (ADS)

Mitrani, James; Kaganovich, Igor; Davidson, Ronald

2013-09-01

A final focusing scheme designed to minimize chromatic effects is discussed. Solenoids are often used for transverse focusing in accelerator systems that require a charged particle beam with a small focal spot and/or large energy density A sufficiently large spread in axial momentum will reduce the effectiveness of transverse focusing, and result in chromatic effects on the final focal spot. Placing a weaker solenoid upstream of a stronger final focusing solenoid (FFS) mitigates chromatic effects on transverse beam focusing. J.M. Mitrani et al., Nucl. Inst. Meth. Phys. Res. A (2013) http://dx.doi.org/10.1016/j.nima.2013.05.09 This work was supported by DOE contract DE-AC02-09CH11466.

Reproducibility of Ultrasound-Guided High Intensity Focused Ultrasound (HIFU) Thermal Lesions in Minimally-Invasive Brain Surgery

NASA Astrophysics Data System (ADS)

Zahedi, Sulmaz

This study aims to prove the feasibility of using Ultrasound-Guided High Intensity Focused Ultrasound (USg-HIFU) to create thermal lesions in neurosurgical applications, allowing for precise ablation of brain tissue, while simultaneously providing real time imaging. To test the feasibility of the system, an optically transparent HIFU compatible tissue-mimicking phantom model was produced. USg-HIFU was then used for ablation of the phantom, with and without targets. Finally, ex vivo lamb brain tissue was imaged and ablated using the USg-HIFU system. Real-time ultrasound images and videos obtained throughout the ablation process showing clear lesion formation at the focal point of the HIFU transducer. Post-ablation gross and histopathology examinations were conducted to verify thermal and mechanical damage in the ex vivo lamb brain tissue. Finally, thermocouple readings were obtained, and HIFU field computer simulations were conducted to verify findings. Results of the study concluded reproducibility of USg-HIFU thermal lesions for neurosurgical applications.

Revisiting COIN Theory and Instruction

DTIC Science & Technology

2009-03-13

Light ning II PE (12-24 Dec) B-10* Analy st Note book/ ARC GIS/ OP Dese rt Light ning II PE B-9...3 Mod B Final Test OP Deser t Light ning II PE (BUB 4) Mod B AAR B-16* Quiz 3 OP Deser t Light ning...Dec) (BUB 3 PMB) Quiz 3 Study Focus B-13* OP Desert Light ning II PE (BUB 2 Bn MB) B-11*

Biomass power for rural development. Technical progress report, January 1, 1997--March 31, 1997

DOE Office of Scientific and Technical Information (OSTI.GOV)

Neuhauser, E.

Detailed task progress reports and schedules are provided for the DOE/USDA sponsored Biomass Power for Rural Development project. The focus of the project is on developing commercial energy crops for power generation by the year 2000. The New York based Salix Consortium project is a multi-partner endeavor, implemented in three stages. Phase-1, Final Design and Project Development, will conclude with the preparation of construction and/or operating permits, feedstock production plans, and contracts ready for signature. Field trials of willow (Salix) have been initiated at several locations in New York (Tully, Lockport, King Ferry, La Fayette, Massena, and Himrod) and co-firingmore » tests are underway at Greenidge Station (NYSEG) and Dunkirk Station (NMPC). Phase-II of the project will focus on scale-up of willow crop acreage, construction of co-firing facilities at Dunkirk Station (NMPC), and final modifications for Greenidge Station. Cofiring willow is also under consideration for GPU`s Seward Station where testing is under way. There will be an evaluation of the energy crop as part of the gasification trials occurring at BED`s McNeill power station. Phase-III will represent fullscale commercialization of the energy crop and power generation on a sustainable basis.« less

Biomass power for rural development. Technical progress report, April 1, 1997--June 30, 1997

DOE Office of Scientific and Technical Information (OSTI.GOV)

Neuhauser, E.

Detailed task progress reports and schedules are provided for the DOE/USDA sponsored Biomass Power for Rural Development project. The focus of the project is on developing commercial energy crops for power generation by the year 2000. The New York based Salix Consortium project is a multi-partner endeavor, implemented in three stages. Phase-I, Final Design and Project Development, will conclude with the preparation of construction and/or operating permits, feedstock production plans, and contracts ready for signature. Field trials of willow (Salix) have been initiated at several locations in New York (Tully, Lockport, King Ferry, La Fayette, Massena, and Himrod) and co-firingmore » tests are underway at Greenidge Station (NYSEG) and Dunkirk Station (NMPC). Phase-H of the project will focus on scale-up of willow crop acreage, construction of co-firing facilities at Dunkirk Station (NMPC), and final modifications for Greenidge Station. Cofiring willow is also under consideration for GPU`s Seward Station where testing is under way. There will be an evaluation of the energy crop as part of the gasification trials occurring at BED`s McNeill power station. Phase-III will represent fullscale commercialization of the energy crop and power generation on a sustainable basis.« less

The NASA Hyper-X Program

NASA Technical Reports Server (NTRS)

Freeman, Delman C., Jr.; Reubush, Daivd E.; McClinton, Charles R.; Rausch, Vincent L.; Crawford, J. Larry

1997-01-01

This paper provides an overview of NASA's Hyper-X Program; a focused hypersonic technology effort designed to move hypersonic, airbreathing vehicle technology from the laboratory environment to the flight environment. This paper presents an overview of the flight test program, research objectives, approach, schedule and status. Substantial experimental database and concept validation have been completed. The program is currently concentrating on the first, Mach 7, vehicle development, verification and validation in preparation for wind-tunnel testing in 1998 and flight testing in 1999. Parallel to this effort the Mach 5 and 10 vehicle designs are being finalized. Detailed analytical and experimental evaluation of the Mach 7 vehicle at the flight conditions is nearing completion, and will provide a database for validation of design methods once flight test data are available.

Whole-machine calibration approach for phased array radar with self-test

NASA Astrophysics Data System (ADS)

Shen, Kai; Yao, Zhi-Cheng; Zhang, Jin-Chang; Yang, Jian

2017-06-01

The performance of the missile-borne phased array radar is greatly influenced by the inter-channel amplitude and phase inconsistencies. In order to ensure its performance, the amplitude and the phase characteristics of radar should be calibrated. Commonly used methods mainly focus on antenna calibration, such as FFT, REV, etc. However, the radar channel also contains T / R components, channels, ADC and messenger. In order to achieve on-based phased array radar amplitude information for rapid machine calibration and compensation, we adopt a high-precision plane scanning test platform for phase amplitude test. A calibration approach for the whole channel system based on the radar frequency source test is proposed. Finally, the advantages and the application prospect of this approach are analysed.

Genetic counselors' (GC) knowledge, awareness, understanding of clinical next-generation sequencing (NGS) genomic testing.

PubMed

Boland, P M; Ruth, K; Matro, J M; Rainey, K L; Fang, C Y; Wong, Y N; Daly, M B; Hall, M J

2015-12-01

Genomic tests are increasingly complex, less expensive, and more widely available with the advent of next-generation sequencing (NGS). We assessed knowledge and perceptions among genetic counselors pertaining to NGS genomic testing via an online survey. Associations between selected characteristics and perceptions were examined. Recent education on NGS testing was common, but practical experience limited. Perceived understanding of clinical NGS was modest, specifically concerning tumor testing. Greater perceived understanding of clinical NGS testing correlated with more time spent in cancer-related counseling, exposure to NGS testing, and NGS-focused education. Substantial disagreement about the role of counseling for tumor-based testing was seen. Finally, a majority of counselors agreed with the need for more education about clinical NGS testing, supporting this approach to optimizing implementation. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

New PSA high concentration solar furnace SF40

NASA Astrophysics Data System (ADS)

Rodriguez, Jose; Cañadas, Inmaculada; Zarza, Eduardo

2016-05-01

A new solar furnace has been designed and built at Plataforma Solar de Almería. In this work, its main components such as heliostat, concentrator, attenuator and test table, and the method used to align them are described. Other equipment like the auxiliary systems necessary for the solar operation, vacuum chamber and gas system are outlined too. Finally, the thermal characteristics of the focus were measured during a test campaign, where different planes along the optical axis were scanned with a radiometer, and the peak flux was obtained and is presented in the last section of this report.

Synthesis and quality control of fluorodeoxyglucose and performance assessment of Siemens MicroFocus 220 small animal PET scanner

NASA Astrophysics Data System (ADS)

Phaterpekar, Siddhesh Nitin

The scope of this article is to cover the synthesis and quality control procedures involved in production of Fludeoxyglucose (18F--FDG). The article also describes the cyclotron production of 18F radioisotope and gives a brief overview on operations and working of a fixed energy medical cyclotron. The quality control procedures for FDG involve radiochemical and radionuclidic purity tests, pH tests, chemical purity tests, sterility tests, endotoxin tests. Each of these procedures were carried out for multiple batches of FDG with a passing rate of 95% among 20 batches. The article also covers the quality assurance steps for the Siemens MicroPET Focus 220 Scanner using a Jaszczak phantom. We have carried out spatial resolution tests on the scanner, with an average transaxial resolution of 1.775mm with 2-3mm offset. Tests involved detector efficiency, blank scan sinograms and transmission sinograms. A series of radioactivity distribution tests are also carried out on a uniform phantom, denoting the variations in radioactivity and uniformity by using cylindrical ROIs in the transverse region of the final image. The purpose of these quality control tests is to make sure the manufactured FDG is biocompatible with the human body. Quality assurance tests are carried on PET scanners for efficient performance, and to make sure the quality of images acquired is according to the radioactivity distribution in the subject of interest.

Real time test bed development for power system operation, control and cyber security

NASA Astrophysics Data System (ADS)

Reddi, Ram Mohan

The operation and control of the power system in an efficient way is important in order to keep the system secure, reliable and economical. With advancements in smart grid, several new algorithms have been developed for improved operation and control. These algorithms need to be extensively tested and validated in real time before applying to the real electric power grid. This work focuses on the development of a real time test bed for testing and validating power system control algorithms, hardware devices and cyber security vulnerability. The test bed developed utilizes several hardware components including relays, phasor measurement units, phasor data concentrator, programmable logic controllers and several software tools. Current work also integrates historian for power system monitoring and data archiving. Finally, two different power system test cases are simulated to demonstrate the applications of developed test bed. The developed test bed can also be used for power system education.

The Development of a Pediatric Inpatient Experience of Care Measure: Child HCAHPS®

PubMed Central

Toomey, Sara L.; Zaslavsky, Alan M.; Elliott, Marc N.; Gallagher, Patricia M.; Fowler, Floyd J.; Klein, David J.; Shulman, Shanna; Ratner, Jessica; McGovern, Caitriona; LeBlanc, Jessica L.; Schuster, Mark A.

2016-01-01

CMS uses Adult HCAHPS® scores for public reporting and pay-for-performance for most U.S. hospitals, but no publicly available standardized survey of inpatient experience of care exists for pediatrics. To fill the gap, CMS/AHRQ commissioned the development of the Consumer Assessment of Healthcare Providers and Systems Hospital Survey – Child Version (Child HCAHPS), a survey of parents/guardians of pediatric patients (<18 years old) who were recently hospitalized. This Special Article describes the development of Child HCAHPS, which included an extensive review of the literature and quality measures, expert interviews, focus groups, cognitive testing, pilot testing of the draft survey, a national field test with 69 hospitals in 34 states, psychometric analysis, and end-user testing of the final survey. We conducted extensive validity and reliability testing to determine which items would be included in the final survey instrument and to develop composite measures. We analyzed national field test data from 17,727 surveys collected from 11/12-1/14 from parents of recently hospitalized children. The final Child HCAHPS instrument has 62 items, including 39 patient experience items, 10 screeners, 12 demographic/descriptive items, and 1 open-ended item. The 39 experience items are categorized based on testing into 18 composite and single-item measures. Our composite and single-item measures demonstrated good to excellent hospital-level reliability at 300 responses per hospital. Child HCAHPS was developed to be a publicly available standardized survey of pediatric inpatient experience of care. It can be used to benchmark pediatric inpatient experience across hospitals and assist in efforts to improve the quality of inpatient care. PMID:26195542

Infrastructure, Components and System Level Testing and Analysis of Electric Vehicles: Cooperative Research and Development Final Report, CRADA Number CRD-09-353

DOE Office of Scientific and Technical Information (OSTI.GOV)

Neubauer, J.

2013-05-01

Battery technology is critical for the development of innovative electric vehicle networks, which can enhance transportation sustainability and reduce dependence on petroleum. This cooperative research proposed by Better Place and NREL will focus on predicting the life-cycle economics of batteries, characterizing battery technologies under various operating and usage conditions, and designing optimal usage profiles for battery recharging and use.

Performance and Costs of Ductless Heat Pumps in Marine-Climate High-Performance Homes -- Habitat for Humanity The Woods

DOE Office of Scientific and Technical Information (OSTI.GOV)

Michael Lubliner; Howard, Luke; Hales, David

2016-02-23

This final Building America Partnership report focuses on the results of field testing, modeling, and monitoring of ductless mini-split heat pump hybrid heating systems in seven homes built and first occupied at various times between September 2013 and October 2014. The report also provides WSU documentation of high-performance home observations, lessons learned, and stakeholder recommendations for builders of affordable high-performance housing.

Methods Used in Economic Evaluations of Chronic Kidney Disease Testing — A Systematic Review

PubMed Central

Sutton, Andrew J.; Breheny, Katie; Deeks, Jon; Khunti, Kamlesh; Sharpe, Claire; Ottridge, Ryan S.; Stevens, Paul E.; Cockwell, Paul; Kalra, Philp A.; Lamb, Edmund J.

2015-01-01

Background The prevalence of chronic kidney disease (CKD) is high in general populations around the world. Targeted testing and screening for CKD are often conducted to help identify individuals that may benefit from treatment to ameliorate or prevent their disease progression. Aims This systematic review examines the methods used in economic evaluations of testing and screening in CKD, with a particular focus on whether test accuracy has been considered, and how analysis has incorporated issues that may be important to the patient, such as the impact of testing on quality of life and the costs they incur. Methods Articles that described model-based economic evaluations of patient testing interventions focused on CKD were identified through the searching of electronic databases and the hand searching of the bibliographies of the included studies. Results The initial electronic searches identified 2,671 papers of which 21 were included in the final review. Eighteen studies focused on proteinuria, three evaluated glomerular filtration rate testing and one included both tests. The full impact of inaccurate test results was frequently not considered in economic evaluations in this setting as a societal perspective was rarely adopted. The impact of false positive tests on patients in terms of the costs incurred in re-attending for repeat testing, and the anxiety associated with a positive test was almost always overlooked. In one study where the impact of a false positive test on patient quality of life was examined in sensitivity analysis, it had a significant impact on the conclusions drawn from the model. Conclusion Future economic evaluations of kidney function testing should examine testing and monitoring pathways from the perspective of patients, to ensure that issues that are important to patients, such as the possibility of inaccurate test results, are properly considered in the analysis. PMID:26465773

[Research progress on mechanical performance evaluation of artificial intervertebral disc].

PubMed

Li, Rui; Wang, Song; Liao, Zhenhua; Liu, Weiqiang

2018-03-01

The mechanical properties of artificial intervertebral disc (AID) are related to long-term reliability of prosthesis. There are three testing methods involved in the mechanical performance evaluation of AID based on different tools: the testing method using mechanical simulator, in vitro specimen testing method and finite element analysis method. In this study, the testing standard, testing equipment and materials of AID were firstly introduced. Then, the present status of AID static mechanical properties test (static axial compression, static axial compression-shear), dynamic mechanical properties test (dynamic axial compression, dynamic axial compression-shear), creep and stress relaxation test, device pushout test, core pushout test, subsidence test, etc. were focused on. The experimental techniques using in vitro specimen testing method and testing results of available artificial discs were summarized. The experimental methods and research status of finite element analysis were also summarized. Finally, the research trends of AID mechanical performance evaluation were forecasted. The simulator, load, dynamic cycle, motion mode, specimen and test standard would be important research fields in the future.

FOCUS: a fire management planning system -- final report

Treesearch

Frederick W. Bratten; James B. Davis; George T. Flatman; Jerold W. Keith; Stanley R. Rapp; Theodore G. Storey

1981-01-01

FOCUS (Fire Operational Characteristics Using Simulation) is a computer simulation model for evaluating alternative fire management plans. This final report provides a broad overview of the FOCUS system, describes two major modules-fire suppression and cost, explains the role in the system of gaming large fires, and outlines the support programs and ways of...

Vista/F-16 Multi-Axis Thrust Vectoring (MATV) control law design and evaluation

NASA Technical Reports Server (NTRS)

Zwerneman, W. D.; Eller, B. G.

1994-01-01

For the Multi-Axis Thrust Vectoring (MATV) program, a new control law was developed using multi-axis thrust vectoring to augment the aircraft's aerodynamic control power to provide maneuverability above the normal F-16 angle of attack limit. The control law architecture was developed using Lockheed Fort Worth's offline and piloted simulation capabilities. The final flight control laws were used in flight test to demonstrate tactical benefits gained by using thrust vectoring in air-to-air combat. Differences between the simulator aerodynamics data base and the actual aircraft aerodynamics led to significantly different lateral-directional flying qualities during the flight test program than those identified during piloted simulation. A 'dial-a-gain' flight test control law update was performed in the middle of the flight test program. This approach allowed for inflight optimization of the aircraft's flying qualities. While this approach is not preferred over updating the simulator aerodynamic data base and then updating the control laws, the final selected gain set did provide adequate lateral-directional flying qualities over the MATV flight envelope. The resulting handling qualities and the departure resistance of the aircraft allowed the 422nd_squadron pilots to focus entirely on evaluating the aircraft's tactical utility.

Very Similar Spacing-Effect Patterns in Very Different Learning/Practice Domains

PubMed Central

Kornmeier, Jürgen; Spitzer, Manfred; Sosic-Vasic, Zrinka

2014-01-01

Temporally distributed (“spaced”) learning can be twice as efficient as massed learning. This “spacing effect” occurs with a broad spectrum of learning materials, with humans of different ages, with non-human vertebrates and also invertebrates. This indicates, that very basic learning mechanisms are at work (“generality”). Although most studies so far focused on very narrow spacing interval ranges, there is some evidence for a non-monotonic behavior of this “spacing effect” (“nonlinearity”) with optimal spacing intervals at different time scales. In the current study we focused both the nonlinearity aspect by using a broad range of spacing intervals and the generality aspect by using very different learning/practice domains: Participants learned German-Japanese word pairs and performed visual acuity tests. For each of six groups we used a different spacing interval between learning/practice units from 7 min to 24 h in logarithmic steps. Memory retention was studied in three consecutive final tests, one, seven and 28 days after the final learning unit. For both the vocabulary learning and visual acuity performance we found a highly significant effect of the factor spacing interval on the final test performance. In the 12 h-spacing-group about 85% of the learned words stayed in memory and nearly all of the visual acuity gain was preserved. In the 24 h-spacing-group, in contrast, only about 33% of the learned words were retained and the visual acuity gain dropped to zero. The very similar patterns of results from the two very different learning/practice domains point to similar underlying mechanisms. Further, our results indicate spacing in the range of 12 hours as optimal. A second peak may be around a spacing interval of 20 min but here the data are less clear. We discuss relations between our results and basic learning at the neuronal level. PMID:24609081

Validity and Reliability of General Nutrition Knowledge Questionnaire for Adults in Uganda

PubMed Central

Bukenya, Richard; Ahmed, Abhiya; Andrade, Jeanette M.; Grigsby-Toussaint, Diana S.; Muyonga, John; Andrade, Juan E.

2017-01-01

This study sought to develop and validate a general nutrition knowledge questionnaire (GNKQ) for Ugandan adults. The initial draft consisted of 133 items on five constructs associated with nutrition knowledge; expert recommendations (16 items), food groups (70 items), selecting food (10 items), nutrition and disease relationship (23 items), and food fortification in Uganda (14 items). The questionnaire validity was evaluated in three studies. For the content validity (study 1), a panel of five content matter nutrition experts reviewed the GNKQ draft before and after face validity. For the face validity (study 2), head teachers and health workers (n = 27) completed the questionnaire before attending one of three focus groups to review the clarity of the items. For the construct and test-rest reliability (study 3), head teachers (n = 40) from private and public primary schools and nutrition (n = 52) and engineering (n = 49) students from Makerere University took the questionnaire twice (two weeks apart). Experts agreed (content validity index, CVI > 0.9; reliability, Gwet’s AC1 > 0.85) that all constructs were relevant to evaluate nutrition knowledge. After the focus groups, 29 items were identified as unclear, requiring major (n = 5) and minor (n = 24) reviews. The final questionnaire had acceptable internal consistency (Cronbach α > 0.95), test-retest reliability (r = 0.89), and differentiated (p < 0.001) nutrition knowledge scores between nutrition (67 ± 5) and engineering (39 ± 11) students. Only the construct on nutrition recommendations was unreliable (Cronbach α = 0.51, test-retest r = 0.55), which requires further optimization. The final questionnaire included topics on food groups (41 items), selecting food (2 items), nutrition and disease relationship (14 items), and food fortification in Uganda (22 items) and had good content, construct, and test-retest reliability to evaluate nutrition knowledge among Ugandan adults. PMID:28230779

Feline leukemia virus and feline immunodeficiency virus in Canada: recommendations for testing and management.

PubMed

Little, Susan; Bienzle, Dorothee; Carioto, Lisa; Chisholm, Hugh; O'Brien, Elizabeth; Scherk, Margie

2011-08-01

Feline leukemia virus (FeLV) and feline immunodeficiency virus (FIV) are common and important infectious disease agents of cats in Canada. Seroprevalence data for FeLV and FIV in various populations of Canadian cats are reviewed and recommendations for testing and management of infections by these viruses in cats in Canada are presented. Retrovirus testing in Canada is infrequent in comparison with the United States, and efforts should be focused on reducing physical and other barriers to testing, and on education of veterinarians, veterinary team members, and cat owners regarding the importance of testing. New test methodologies for FeLV and FIV are emerging, and should be independently evaluated in order to provide practitioners with information on test reliability. Finally, more information is needed on FIV subtypes in Canada to improve diagnostics and vaccines, and to provide information on disease outcomes.

High Alpha Technology Program (HATP) ground test to flight comparisons

NASA Technical Reports Server (NTRS)

Hall, R. M.; Banks, D. W.; Fisher, David F.; Ghaffari, F.; Murri, D. G.; Ross, J. C.; Lanser, Wendy R.

1994-01-01

This status paper reviews the experimental ground test program of the High Alpha Technology Program (HATP). The reasons for conducting this ground test program had their origins during the 1970's when several difficulties were experienced during the development programs of both the F-18 and F-16. A careful assessment of ground test to flight correlations appeared to be important for reestablishing a high degree of confidence in our ground test methodology. The current paper will then focus on one aspect of the HATP program that is intended to improve the correlation between ground test and flight, high-alpha gritting. The importance of this work arises from the sensitivity of configurations with smooth-sided forebodies to Reynolds number. After giving examples of the effects of Reynolds number, the paper will highlight efforts at forebody gritting. Finally, the paper will conclude by summarizing the charter of the HATP Experimental Aerodynamics Working Group and future experimental testing plans.

Saturn Apollo Program

NASA Image and Video Library

1967-01-01

This photograph is a view of the Saturn V S-IC (first) test stage being hoisted into the S-IC-B1 test stand at the Mississippi Test Facility (MTF), Bay St. Louis, Mississippi. This stage was used to prove the operational readiness of the stand. Begirning operations in 1966, the MTF has two test stands; a dual-position structure for running the S-IC stage at full throttle, and two separate stands for the S-II (Saturn V third) stage. It became the focus of the static test firing program. The completed S-IC stage was shipped from the Michoud Assembly Facility (MAF) to the MTF. The stage was then installed into the 124-meter-high test stand for static firing tests before shipment to the Kennedy Space Center for final assembly of the Saturn V vehicle. The MTF was renamed to the National Space Technology Laboratory (NSTL) in 1974 and later to the Stennis Space Center (SSC) in May 1988.

Saturn Apollo Program

NASA Image and Video Library

1967-08-01

This photograph is a view of the Saturn V S-IC-5 (first) flight stage static test firing at the S-IC-B1 test stand at the Mississippi Test Facility (MTF), Bay St. Louis, Mississippi. Begirning operations in 1966, the MTF has two test stands, a dual-position structure for running the S-IC stage at full throttle, and two separate stands for the S-II (Saturn V third) stage. It became the focus of the static test firing program. The completed S-IC stage was shipped from Michoud Assembly Facility (MAF) to the MTF. The stage was then installed into the 407-foot-high test stand for the static firing tests before shipment to the Kennedy Space Center for final assembly of the Saturn V vehicle. The MTF was renamed to the National Space Technology Laboratory (NSTL) in 1974 and later to the Stennis Space Center (SSC) in May 1988.

Fabrication of Glass Microchannel via Glass Imprinting using a Vitreous Carbon Stamp for Flow Focusing Droplet Generator

PubMed Central

Refatul Haq, Muhammad; Kim, Youngkyu; Kim, Jun; Oh, Pyoung-hwa; Ju, Jonghyun; Kim, Seok-Min; Lim, Jiseok

2017-01-01

This study reports a cost-effective method of replicating glass microfluidic chips using a vitreous carbon (VC) stamp. A glass replica with the required microfluidic microstructures was synthesized without etching. The replication method uses a VC stamp fabricated by combining thermal replication using a furan-based, thermally-curable polymer with carbonization. To test the feasibility of this method, a flow focusing droplet generator with flow-focusing and channel widths of 50 µm and 100 µm, respectively, was successfully fabricated in a soda-lime glass substrate. Deviation between the geometries of the initial shape and the vitreous carbon mold occurred because of shrinkage during the carbonization process, however this effect could be predicted and compensated for. Finally, the monodispersity of the droplets generated by the fabricated microfluidic device was evaluated. PMID:29286341

[Direct-to-consumer genetic testing through Internet: marketing, ethical and social issues].

PubMed

Ducournau, Pascal; Gourraud, Pierre-Antoine; Rial-Sebbag, Emmanuelle; Bulle, Alexandre; Cambon-Thomsen, Anne

2011-01-01

We probably did not anticipate all the consequences of the direct to consumer genetic tests on Internet, resulting from the combined skills of communication and genomic advances. What are the commercial strategies used by the companies offering direct-to-consumer genetic tests on Internet and what are the different social expectations on which they focus? Through a quantitative and qualitative analysis of the web sites offering such tests, it seems that these companies target a triple market based on: the "healthism" which raises health and hygiene to the top of the social values; the contemporary demands of the users to become actual actors of health decisions; and finally on the need for bio-social relationships. These three commercial strategies underlie various ethical and societal issues justifying a general analysis.

Instrument development of causalitic thinking approach in physics learning to increase problem solving ability of pre-service teachers

NASA Astrophysics Data System (ADS)

Rokhmat, Joni; Marzuki, Hikmawati, Verawati, Ni Nyoman Sri Putu

2017-01-01

It has been developed instruments of Causalitic Thinking Approach (CTA) in Physics learning to increase Problem Solving Ability (PSA) of pre-service teachers (low and high groups). Causalitic means causality and analitic. Implementation of the CTA at kinematics and Newton's law about movement increased the PSA of students (significance 5%) and the increases were not different between the low and high groups. PSA includes abilities of understanding (IPSA-1), selecting (IPSA-2), differentiating (IPSA-3), determining (IPSA-4), applying (IPSA-5), and identifying (IPSA-6). The differences between pre-test (initial PSA) and post-test (final PSA), and between PSA-gain of low and high groups were tested using Wilcoxon signed-ranks test. Pairs of tcounted and ttable (tcount, ttable) at IPSA-1 to IPSA-6 for low group were (2,-), (0,5), (0,2), (0,0), (0,3), (0,0) at kinematics and (0,5), (0,5), (0,2), (0,5), (0,2), (0,0) at Newton's law. While, for high group, the pairs were (0,5), (0,5), (0,3), (0,3), (0,3), (0,0) at kinematics and (0,2), (0,5), (0,2), (0,3), (0,5), (0,2) at Newton's law. Finally, pairs of tcounted and ttable (tcounted, ttable) for the PSA gain differences were (0,3), (4,0), (5,2), (13.5,5), (5,2), (5,2) at kinematics and (3,2), (12,5), (10.5,5), (2,0), (8.5,5), (10.5,) at Newton's law. The value of ttable is related to the number of effective data pairs (for 6, 7, 8, and 9 pairs, the ttable respectively are 0, 2, 3, and 5). This first of three year research used mixed method of embedded experimental two-phase design and involved 49 students (39 females). The CTA facilitated students to develop ability of causality and analytic thinking. To solve phenomenon, students determined all causes and deductively predicted all of possible effects, and finally identified conditions of each causes which resulted in each effects. This paper will focus at three focus discussions, i.e. instruments of CTA, PSA increases, and responds of students to the instruments.

Value-Focused Objectives Model for Community Resilience

DTIC Science & Technology

2014-04-01

Value-focused objectives model for community resilience : Final report Prepared by: Jay Adamsson CAE Integrated Enterprise Solutions...2014 Value-Focused Objectives Model for Community Resilience Final Report 24 March 2014 – iv – 5606-002 Version 01 T A B L E O F C O N T E... Community Resilience ......................................................... 13 APPENDIX A LIST OF ACRONYMS

Final Environmental Assessment: Demolition/Restoration of Ipswich Antenna Test Facility

DTIC Science & Technology

2012-05-01

sourc--es \\ Veta quantified b y using fual oU e onsu.mption from the-last full yesr of use ( CY20 1 0). Buildings S-3, S-5, and S-15 ware haated b y #2...the environment. E nvironmental Consequences Environmental analyses focused on the following areas: land use, socioeconomics, utilities...the wetland as possib I e . In addition the Conservation Commission may impose additional requirements such as: staking the wetland boundaries

The National Guard Ballistic Missile Defense Mission: Minutemen at the Orbital Plane

DTIC Science & Technology

2004-09-01

2001, he guided me through a change in Thesis Topic, an extension, an interruption while mobilized for Operation Enduring Freedom, the final extension...Command changes its focus.” Army News Service, Washington, DC. Copy obtained from the Internet at [http://www.defenselink.mil] (15 July 1996). 4...testing phase. 12 Kozaryn, Linda D., “Army Reserve Duty Has ’ Changed Forever’” The comments of US Army Reserve Chief, Lt. Gen. Thomas J. Plewes

Instructional Modules for Training Special Education Teachers: A Final Report on the Development and Field Testing of the CUNY-CBTEP Special Education Modules. Case 30-76. Toward Competence Instructional Materials for Teacher Education.

ERIC Educational Resources Information Center

City Univ. of New York, NY. Center for Advanced Study in Education.

The City University of New York Competency Based Teacher Education Project (CUNY-CBTEP) in Special Education studied Modularization, focusing on the variables in the instructional setting that facilitate learning from modular materials for a wide range of students. Four of the five modules for the training of special education teachers developed…

Brain Computer Interfaces for Enhanced Interaction with Mobile Robot Agents

DTIC Science & Technology

2016-07-27

synergistic and complementary way. This project focused on acquiring a mobile robotic agent platform that can be used to explore these interfaces...providing a test environment where the human control of a robot agent can be experimentally validated in 1. REPORT DATE (DD-MM-YYYY) 4. TITLE AND...Distribution Unlimited UU UU UU UU 27-07-2016 17-Sep-2013 16-Sep-2014 Final Report: Brain Computer Interfaces for Enhanced Interactions with Mobile Robot

Recent Progress at NASA in LlSA Formulation and Technology Development

NASA Technical Reports Server (NTRS)

Stebbins, Robin

2007-01-01

Over the last year, the NASA portion of the LISA team has been focused its effort on advancing the formulation of the mission and responding to a major National Academy review. This talk will describe advances in, and the current state of: the baseline mission architecture, the performance requirements, the technology development and plans for final integration and test. Interesting results stimulated by the NASINRC Beyond Einstein Program Assessment Review will also be described.

Radiation damage and waste management options for the SOMBRERO final focus system and neutron dumps

DOE Office of Scientific and Technical Information (OSTI.GOV)

Latkowski, J F; Meier, W R; Reyes, S

1999-08-09

Previous studies of the safety and environmental aspects of the SOMBRERO inertial fusion energy (IFE) power plant design did not completely address the issues associated with the final focus system. While past work calculated neutron fluences for a grazing incidence metal mirror (GIMM) and a final focus mirror, scattering off of the final optical component was not included, and thus, fluences in the final focus mirror were significantly underestimated. In addition, past work did not consider neutron-induced gamma-rays. Finally, power plant lifetime waste volumes may have been underestimated as neutron activation of the neutron dumps and building structure were notmore » addressed. In the present work, a modified version of the SOMBRERO target building is presented where a significantly larger open solid-angle fraction (5%) is used to enhance beam smoothing of a diode-pumped solid-state laser (DPSSL). The GIMMs are replaced with transmissive fused silica wedges and have been included in three -dimensional neutron and photon transport calculations. This work shows that a power plant with a large open solid-angle fraction, needed for beam smoothing with a DPSSL, is acceptable from tritium breeding, and neutron activation points-of-view.« less

Biomass power for rural development. Technical progress report, October 1--December 31, 1997

DOE Office of Scientific and Technical Information (OSTI.GOV)

Neuhauser, E.

The focus of the DOE/USDA sponsored biomass power for rural development project is to develop commercial energy crops for power generation by the year 2000. The New York based Salix Consortium project is a multi-partner endeavor, implemented in three stages. Phase-1, Final Design and Project Development, will conclude with the preparation of construction and/or operating permits, feedstock production plans, and contracts ready for signature. Field trials of willow (Salix) have been initiated at several locations in New York (Tully, Lockport, King Ferry, La Fayette, Massena, and Himrod) and co-firing tests are underway at Greenidge Station (NYSEG) and Dunkirk Station (NMPC).more » Phase-2 of the project will focus on scale-up of willow crop acreage, construction of co-firing facilities at Dunkirk Station (NMPC), and final modifications for Greenidge Station. Cofiring willow is also under consideration for GPU`s Seward Station where testing is underway. There will be an evaluation of the energy crop as part of the gasification trials occurring at BED`s McNeill Power Station. Phase-3 will represent fullscale commercialization of the energy crop and power generation on a sustainable basis. During the fourth quarter of 1997 the Consortium submitted a Phase-2 proposal. A few of the other more important milestones are outlined below. The first quarter of 1998 will be dominated by pre-planting activity in the spring.« less

Thermal Analysis of Small Re-Entry Probe

NASA Technical Reports Server (NTRS)

Agrawal, Parul; Prabhu, Dinesh K.; Chen, Y. K.

2012-01-01

The Small Probe Reentry Investigation for TPS Engineering (SPRITE) concept was developed at NASA Ames Research Center to facilitate arc-jet testing of a fully instrumented prototype probe at flight scale. Besides demonstrating the feasibility of testing a flight-scale model and the capability of an on-board data acquisition system, another objective for this project was to investigate the capability of simulation tools to predict thermal environments of the probe/test article and its interior. This paper focuses on finite-element thermal analyses of the SPRITE probe during the arcjet tests. Several iterations were performed during the early design phase to provide critical design parameters and guidelines for testing. The thermal effects of ablation and pyrolysis were incorporated into the final higher-fidelity modeling approach by coupling the finite-element analyses with a two-dimensional thermal protection materials response code. Model predictions show good agreement with thermocouple data obtained during the arcjet test.

Saturn Apollo Program

NASA Image and Video Library

1967-01-01

This photograph is a view of the Saturn V S-IC-5 (first) flight stage being hoisted into the S-IC-B1 test stand at the Mississippi Test Facility (MTF), Bay St. Louis, Mississippi. Begirning operations in 1966, the MTF has two test stands, a dual-position structure for running the S-IC stage at full throttle, and two separate stands for the S-II (Saturn V third) stage. It became the focus of the static test firing program. The completed S-IC stage was shipped from Michoud Assembly Facility (MAF) to the MTF. The stage was then installed into the 124-meter-high test stand for static firing tests before shipment to the Kennedy Space Center for final assembly of the Saturn V vehicle. The MTF was renamed to the National Space Technology Laboratory (NSTL) in 1974 and later to the Stennis Space Center (SSC) in May 1988.

Acoustic emission non-destructive testing of structures using source location techniques.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beattie, Alan G.

2013-09-01

The technology of acoustic emission (AE) testing has been advanced and used at Sandia for the past 40 years. AE has been used on structures including pressure vessels, fire bottles, wind turbines, gas wells, nuclear weapons, and solar collectors. This monograph begins with background topics in acoustics and instrumentation and then focuses on current acoustic emission technology. It covers the overall design and system setups for a test, with a wind turbine blade as the object. Test analysis is discussed with an emphasis on source location. Three test examples are presented, two on experimental wind turbine blades and one onmore » aircraft fire extinguisher bottles. Finally, the code for a FORTRAN source location program is given as an example of a working analysis program. Throughout the document, the stress is on actual testing of real structures, not on laboratory experiments.« less

Test Anxiety in Spanish Adolescents: Examining the Role of Emotional Attention, and Ruminative Self-focus and Regulation

PubMed Central

Pena, Mario; Losada, Lidia

2017-01-01

Emotional attention has been found as a key predictive dimension of stress. However, very few studies have investigated the relationship between emotional attention and test anxiety. The objective of the present study was to analyze the role of emotional attention, measured using the Trait Meta-Mood Scale (TMMS), on the level of test anxiety, and measured using the Test Anxiety Inventory (TAI). In addition, we examined the potential mediating role of Self-Rumination and Self-Reflection, as measured through the Rumination-Reflection Questionnaire (RRQ), on the relationship between emotional attention and test anxiety. The sample included 385 Spanish adolescents between 14 and 19 years of age. Mediation analysis results are consistent with a model in which Self-Rumination, but no Self-Reflection, mediates the relationship between Emotional Attention and Test Anxiety. Finally, several potential implications of these findings to improve quality of life in adolescents are discussed. PMID:28871234

Characterization of an In-Situ Ground Terminal via a Geostationary Satellite

NASA Technical Reports Server (NTRS)

Piasecki, Marie T.; Welch, Bryan W.; Mueller, Carl H.

2015-01-01

In 2015, the Space Communications and Navigation (SCaN) Testbed project completed an S-Band ground station located at the NASA Glenn Research Center in Cleveland, Ohio. This S-Band ground station was developed to create a fully characterized and controllable dynamic link environment when testing novel communication techniques for Software Defined Radios and Cognitive Communication Systems. In order to provide a useful environment for potential experimenters, it was necessary to characterize various RF devices at both the component level in the laboratory and at the system level after integration. This paper will discuss some of the laboratory testing of the ground station components, with a particular focus/emphasis on the near-field measurements of the antenna. It will then describe the methodology for characterizing the installed ground station at the system level via a Tracking and Data Relay Satellite (TDRS), with specific focus given to the characterization of the ground station antenna pattern, where the max TDRS transmit power limited the validity of the non-noise floor received power data to the antenna main lobe region. Finally, the paper compares the results of each test as well as provides lessons learned from this type of testing methodology.

Characterization of an In-Situ Ground Terminal via a Geostationary Satellite

NASA Technical Reports Server (NTRS)

Piasecki, Marie; Welch, Bryan; Mueller, Carl

2015-01-01

In 2015, the Space Communications and Navigation (SCaN) Testbed project completed an S-Band ground station located at the NASA Glenn Research Center in Cleveland, Ohio. This S-Band ground station was developed to create a fully characterized and controllable dynamic link environment when testing novel communication techniques for Software Defined Radios and Cognitive Communication Systems. In order to provide a useful environment for potential experimenters, it was necessary to characterize various RF devices at both the component level in the laboratory and at the system level after integration. This paper will discuss some of the laboratory testing of the ground station components, with a particular focus emphasis on the near-field measurements of the antenna. It will then describe the methodology for characterizing the installed ground station at the system level via a Tracking and Data Relay Satellite (TDRS), with specific focus given to the characterization of the ground station antenna pattern, where the max TDRS transmit power limited the validity of the non-noise floor received power data to the antenna main lobe region. Finally, the paper compares the results of each test as well as provides lessons learned from this type of testing methodology.

Technologies for Decreasing Mining Losses

NASA Astrophysics Data System (ADS)

Valgma, Ingo; Väizene, Vivika; Kolats, Margit; Saarnak, Martin

2013-12-01

In case of stratified deposits like oil shale deposit in Estonia, mining losses depend on mining technologies. Current research focuses on extraction and separation possibilities of mineral resources. Selective mining, selective crushing and separation tests have been performed, showing possibilities of decreasing mining losses. Rock crushing and screening process simulations were used for optimizing rock fractions. In addition mine backfilling, fine separation, and optimized drilling and blasting have been analyzed. All tested methods show potential and depend on mineral usage. Usage in addition depends on the utilization technology. The questions like stability of the material flow and influences of the quality fluctuations to the final yield are raised.

Choice Inconsistencies among the Elderly: Evidence from Plan Choice in the Medicare Part D Program: Reply

PubMed Central

ABALUCK, JASON

2017-01-01

We explore the in- and out- of sample robustness of tests for choice inconsistencies based on parameter restrictions in parametric models, focusing on tests proposed by Ketcham, Kuminoff and Powers (KKP). We argue that their non-parametric alternatives are inherently conservative with respect to detecting mistakes. We then show that our parametric model is robust to KKP’s suggested specification checks, and that comprehensive goodness of fit measures perform better with our model than the expected utility model. Finally, we explore the robustness of our 2011 results to alternative normative assumptions highlighting the role of brand fixed effects and unobservable characteristics. PMID:29170561

A mixed method pilot study: the researchers' experiences.

PubMed

Secomb, Jacinta M; Smith, Colleen

2011-08-01

This paper reports on the outcomes of a small well designed pilot study. Pilot studies often disseminate limited or statistically meaningless results without adding to the body knowledge on the comparative research benefits. The design a pre-test post-test group parallel randomised control trial and inductive content analysis of focus group transcripts was tested specifically to increase outcomes in a proposed larger study. Strategies are now in place to overcome operational barriers and recruitment difficulties. Links between the qualitative and quantitative arms of the proposed larger study have been made; it is anticipated that this will add depth to the final report. More extensive reporting on the outcomes of pilot studies would assist researchers and increase the body of knowledge in this area.

Test equality between two binary screening tests with a confirmatory procedure restricted on screen positives.

PubMed

Lui, Kung-Jong; Chang, Kuang-Chao

2015-01-01

In studies of screening accuracy, we may commonly encounter the data in which a confirmatory procedure is administered to only those subjects with screen positives for ethical concerns. We focus our discussion on simultaneously testing equality of sensitivity and specificity between two binary screening tests when only subjects with screen positives receive the confirmatory procedure. We develop four asymptotic test procedures and one exact test procedure. We derive sample size calculation formula for a desired power of detecting a difference at a given nominal [Formula: see text]-level. We employ Monte Carlo simulation to evaluate the performance of these test procedures and the accuracy of the sample size calculation formula developed here in a variety of situations. Finally, we use the data obtained from a study of the prostate-specific-antigen test and digital rectal examination test on 949 Black men to illustrate the practical use of these test procedures and the sample size calculation formula.

Final Report Feasibility Study for the California Wave Energy Test Center (CalWavesm)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blakeslee, Samuel Norman; Toman, William I.; Williams, Richard B.

The California Wave Energy Test Center (CalWave) Feasibility Study project was funded over multiple phases by the Department of Energy to perform an interdisciplinary feasibility assessment to analyze the engineering, permitting, and stakeholder requirements to establish an open water, fully energetic, grid connected, wave energy test center off the coast of California for the purposes of advancing U.S. wave energy research, development, and testing capabilities. Work under this grant included wave energy resource characterization, grid impact and interconnection requirements, port infrastructure and maritime industry capability/suitability to accommodate the industry at research, demonstration and commercial scale, and macro and micro sitingmore » considerations. CalWave Phase I performed a macro-siting and down-selection process focusing on two potential test sites in California: Humboldt Bay and Vandenberg Air Force Base. This work resulted in the Vandenberg Air Force Base site being chosen as the most favorable site based on a peer reviewed criteria matrix. CalWave Phase II focused on four siting location alternatives along the Vandenberg Air Force Base coastline and culminated with a final siting down-selection. Key outcomes from this work include completion of preliminary engineering and systems integration work, a robust turnkey cost estimate, shoreside and subsea hazards assessment, storm wave analysis, lessons learned reports from several maritime disciplines, test center benchmarking as compared to existing international test sites, analysis of existing applicable environmental literature, the completion of a preliminary regulatory, permitting and licensing roadmap, robust interaction and engagement with state and federal regulatory agency personnel and local stakeholders, and the population of a Draft Federal Energy Regulatory Commission (FERC) Preliminary Application Document (PAD). Analysis of existing offshore oil and gas infrastructure was also performed to assess the potential value and re-use scenarios of offshore platform infrastructure and associated subsea power cables and shoreside substations. The CalWave project team was well balanced and was comprised of experts from industry, academia, state and federal regulatory agencies. The result of the CalWave feasibility study finds that the CalWave Test Center has the potential to provide the most viable path to commercialization for wave energy in the United States.« less

Biomass power for rural development. Technical progress report, July 1--September 30, 1997

DOE Office of Scientific and Technical Information (OSTI.GOV)

Neuhauser, E.

The focus of the DOE/USDA sponsored biomass power for rural development project is to develop commercial energy crops for power generation by the year 2000. The New York based Salix Consortium project is a multi-partner endeavor, implemented in three stages. Phase-1, Final Design and Project Development, will conclude with the preparation of construction and/or operating permits, feedstock production plans, and contracts ready for signature. Field trials of willow (Salix) have been initiated at several locations in New York (Tully, Lockport, King Ferry, La Fayette, Massena, and Himrod) and co-firing tests are underway at Greenidge Station (NYSEG) and Dunkirk Station (NMPC).more » Phase-2 of the project will focus on scale-up of willow crop acreage, construction of co-firing facilities at Dunkirk Station (NMPC), and final modifications for Greenidge Station. Cofiring willow is also under consideration for GPU`s Seward Station where testing is underway. There will be an evaluation of the energy crop as part of the gasification trials occurring at BED`s McNeill power station. Phase-3 will represent fullscale commercialization of the energy crop and power generation on a sustainable basis. During the third quarter of 1997, much of the Consortium`s effort has focused on outreach activities, continued feedstock development, fuel supply planning, and fuel contract development, and preparation for 1998 scale-up activities. The Consortium also submitted a Phase-1 extension proposal during this period. A few of the more important milestones are outlined below. The fourth quarter of 1997 is expected to be dominated by Phase-II proposal efforts and planning for 1998 activities.« less

Worldwide Research, Worldwide Participation: Web-Based Test Logger

NASA Technical Reports Server (NTRS)

Clark, David A.

1998-01-01

Thanks to the World Wide Web, a new paradigm has been born. ESCORT (steady state data system) facilities can now be configured to use a Web-based test logger, enabling worldwide participation in tests. NASA Lewis Research Center's new Web-based test logger for ESCORT automatically writes selected test and facility parameters to a browser and allows researchers to insert comments. All data can be viewed in real time via Internet connections, so anyone with a Web browser and the correct URL (universal resource locator, or Web address) can interactively participate. As the test proceeds and ESCORT data are taken, Web browsers connected to the logger are updated automatically. The use of this logger has demonstrated several benefits. First, researchers are free from manual data entry and are able to focus more on the tests. Second, research logs can be printed in report format immediately after (or during) a test. And finally, all test information is readily available to an international public.

Cooperative remote sensing and actuation using networked unmanned vehicles

NASA Astrophysics Data System (ADS)

Chao, Haiyang

This dissertation focuses on how to design and employ networked unmanned vehicles for remote sensing and distributed control purposes in the current information-rich world. The target scenarios are environmental or agricultural applications such as river/reservoir surveillance, wind profiling measurement, and monitoring/control of chemical leaks, etc. AggieAir, a small and low-cost unmanned aircraft system, is designed based on the remote sensing requirements from environmental monitoring missions. The state estimation problem and the advanced lateral flight controller design problem are further attacked focusing on the small unmanned aerial vehicle (UAV) platform. Then the UAV-based remote sensing problem is focused with further flight test results. Given the measurements from unmanned vehicles, the actuation algorithms are needed for missions like the diffusion control. A consensus-based central Voronoi tessellation (CVT) algorithm is proposed for better control of the diffusion process. Finally, the dissertation conclusion and some new research suggestions are presented.

Theory and Experimental Program for p-B11 Fusion with the Dense Plasma Focus

NASA Astrophysics Data System (ADS)

Lerner, Eric J.; Krupakar Murali, S.; Haboub, A.

2011-10-01

Lawrenceville Plasma Physics Inc. has initiated a 2-year-long experimental project to test the scientific feasibility of achieving controlled fusion using the dense plasma focus (DPF) device with hydrogen-boron (p-B11) fuel. The goals of the experiment are: first, to confirm the achievement of high ion and electron energies observed in previous experiments from 2001; second, to greatly increase the efficiency of energy transfer into the plasmoid where the fusion reactions take place; third, to achieve the high magnetic fields (>1 GG) needed for the quantum magnetic field effect, which will reduce cooling of the plasma by X-ray emission; and finally, to use p-B11 fuel to demonstrate net energy gain. The experiments are being conducted with a newly constructed dense plasma focus in Middlesex, NJ which is expected to generate peak currents in excess of 2 MA. Some preliminary results are reported.

Expert system verification and validation study. Delivery 3A and 3B: Trip summaries

NASA Technical Reports Server (NTRS)

French, Scott

1991-01-01

Key results are documented from attending the 4th workshop on verification, validation, and testing. The most interesting part of the workshop was when representatives from the U.S., Japan, and Europe presented surveys of VV&T within their respective regions. Another interesting part focused on current efforts to define industry standards for artificial intelligence and how that might affect approaches to VV&T of expert systems. The next part of the workshop focused on VV&T methods of applying mathematical techniques to verification of rule bases and techniques for capturing information relating to the process of developing software. The final part focused on software tools. A summary is also presented of the EPRI conference on 'Methodologies, Tools, and Standards for Cost Effective Reliable Software Verification and Validation. The conference was divided into discussion sessions on the following issues: development process, automated tools, software reliability, methods, standards, and cost/benefit considerations.

Experimental and finite element investigation of the buckling characteristics of a beaded skin panel for a hypersonic aircraft. Ph.D. Thesis. Final Report

NASA Technical Reports Server (NTRS)

Siegel, W. H.

1978-01-01

As part of NASA's continuing research into hypersonics and 85 square foot hypersonic wing test section of a proposed hypersonic research airplane was laboratory tested. The project reported on in this paper has carried the hypersonic wing test structure project one step further by testing a single beaded panel to failure. The primary interest was focused upon the buckling characteristics of the panel under pure compression with boundary conditions similar to those found in a wing mounted condition. Three primary phases of analysis are included in the report. These phases include: experimental testing of the beaded panel to failure; finite element structural analysis of the beaded panel with the computer program NASTRAN; a summary of the semiclassical buckling equations for the beaded panel under purely compressive loads. Comparisons between each of the analysis methods are also included.

UAS in the NAS Flight Test Series 4 Overview

NASA Technical Reports Server (NTRS)

Murphy, Jim

2016-01-01

Flight Test Series 4 (FT4) provides the researchers with an opportunity to expand on the data collected during the first flight tests. Following Flight Test Series 3, additional scripted encounters with different aircraft performance and sensors will be conducted. FT4 is presently planned for Spring of 2016 to ensure collection of data to support the validation of the final RTCA Phase 1 DAA (Detect and Avoid) Minimum Operational Performance Standards (MOPS). There are three research objectives associated with this goal: Evaluate the performance of the DAA system against cooperative and non-cooperative aircraft encounters Evaluate UAS (Unmanned Aircraft Systems) pilot performance in response to DAA maneuver guidance and alerting with live intruder encounters Evaluate TCAS/DAA (Traffic Alert and Collision Avoidance System/Detect and Avoid) interoperability. This flight test series will focus on only the Scripted Encounters configuration, supporting the collection of data to validate the interoperability of DAA and collision avoidance algorithms.

Modelling Gravitational Radiation from Binary Black Holes

NASA Technical Reports Server (NTRS)

Centrella, Joan

2006-01-01

The final merger and coalescence of binary black holes is a key source of strong gravitational waves for the LISA mission. Observing these systems will allow us to probe the formation of cosmic structure to high redshifts and test general relativity directly in the strong-field, dynamical regime. Recently, major breakthroughs have been made in modeling black hole mergers using numerical relativity. This talk will survey these exciting developments, focusing on the gravitational waveforms and the recoil kicks produced from non-equal mass mergers.

UTM Data Working Group Demonstration 1: Final Report

NASA Technical Reports Server (NTRS)

Rios, Joseph L.; Mulfinger, Daniel G.; Smith, Irene S.; Venkatesan, Priya; Smith, David R.; Baskaran, Vijayakumar; Wang, Leo

2017-01-01

This document summarizes activities defining and executing the first demonstration of the NASA-FAA Research Transition Team (RTT) Data Exchange and Information Architecture (DEIA) working group (DWG). The demonstration focused on testing the interactions between two key components in the future UAS Traffic Management (UTM) System through a collaborative and distributed simulation of key scenarios. The summary incorporates written feedback from each of the participants in the demonstration. In addition to reporting the activities, this report also provides some insight into future steps of this working group.

Focused Feasibility Study Final Health and Safety Plan. Beach Point Test Site, Aberdeen Proving Ground, Edgewood Area, Maryland.

DTIC Science & Technology

1993-10-01

brimmed hats can help prevent sunburn. Chronic exposure to UV radiation is known to cause skin cancer. In case of sunburn, do not apply burn ointment ...personnel who have the potential to be exposed to hazardous or toxic substances or environments during the course of field activities. Each member of the...investigations who are exposed or potentially exposed to hazardous substances or health hazards at or above the established exposure levels for these substances

Joint Aircraft Survivability Program Final Test Report for the Acoustic Fire Suppression Project JASP-TR-14-05

DTIC Science & Technology

2016-09-01

focus of early research was the effects of acoustics on droplet burning in turbine engines and combustion chambers.5,21–23 The results of this... Wire Anemometer. Time-resolved mass readings were made using a model MS4002S Mettler Toledo Precision Balance. 5. Acoustic Extinction This section...nanotube sound projectors. Nanotechnology. 2013;24(23):235501. 40. Hu L, Liu S, Xu Y, Li D. A wind tunnel experimental study on burning rate

Lessons learned from the SLC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Phinney, N.

The SLAC Linear Collider (SLC) is the first example of an entirely new type of lepton collider. Many years of effort were required to develop the understanding and techniques needed to approach design luminosity. This paper discusses some of the key issues and problems encountered in producing a working linear collider. These include the polarized source, techniques for emittance preservation, extensive feedback systems, and refinements in beam optimization in the final focus. The SLC experience has been invaluable for testing concepts and developing designs for a future linear collider.

The FONT5 Bunch-by-Bunch Position and Angle Feedback System at ATF2

NASA Astrophysics Data System (ADS)

Apsimon, R. J.; Bett, D. R.; Burrows, P. N.; Christian, G. B.; Constance, B.; Davis, M. R.; Gerbershagen, A.; Perry, C.; Resta-Lopez, J.

The FONT5 upstream beam-based feedback system at ATF2 is designed to correct the position and angle jitter at the entrance to the ATF2 final-focus system, and also to demonstrate a prototype intra-train feedback system for the International Linear Collider interaction point. We discuss the hardware, from stripline BPMs to kickers, and RF and digital signal processing, as well as presenting results from the latest beam tests at ATF2.

The NASA Juncture Flow Experiment: Goals, Progress, and Preliminary Testing (Invited)

NASA Technical Reports Server (NTRS)

Rumsey, Christopher L.; Neuhart, Danny H.; Kegerise, Michael A.

2016-01-01

NASA has been working toward designing and conducting a juncture flow experiment on a wing-body aircraft configuration. The experiment is planned to provide validation-quality data for CFD that focuses on the onset and progression of a separation bubble near the wing-body juncture trailing edge region. This paper describes the goals and purpose of the experiment. Although currently considered unreliable, preliminary CFD analyses of several different configurations are shown. These configurations have been subsequently tested in a series of "risk-reduction" wind tunnel tests, in order to help down-select to a final configuration that will attain the desired flow behavior. The risk-reduction testing at the higher Reynolds number has not yet been completed (at the time of this writing), but some results from one of the low-Reynolds-number experiments are shown.

Alloy 690 qualification: Corrosion under prototypic heat flux and temperature conditions. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baum, A.J.

1995-05-01

The objective of this program was to perform qualification tests of industrial heats of thermally treated alloy 690 steam generator tubing under heat transfer conditions. Primary emphasis was focused on testing of alternate tube to tubesheet expansion processes. In addition, a background report was written to document the evolution of the alloy 690 process specification and the supporting qualification testing. While the testing was able to produce some localized corrosion of alloy 690 in the tube to tubesheet joint transition regions under highly alkaline conditions, the corrosion rates were between two and three orders of magnitude lower than the comparablemore » rates in mill annealed alloy 600 tubing. The corrosion morphology was a combination of intergranular and general corrosion, rather than the stress corrosion cracking typically found in mill annealed alloy 600 tubing.« less

The opto-mechanical design process: from vision to reality

NASA Astrophysics Data System (ADS)

Kvamme, E. Todd; Stubbs, David M.; Jacoby, Michael S.

2017-08-01

The design process for an opto-mechanical sub-system is discussed from requirements development through test. The process begins with a proper mission understanding and the development of requirements for the system. Preliminary design activities are then discussed with iterative analysis and design work being shared between the design, thermal, and structural engineering personnel. Readiness for preliminary review and the path to a final design review are considered. The value of prototyping and risk mitigation testing is examined with a focus on when it makes sense to execute a prototype test program. System level margin is discussed in general terms, and the practice of trading margin in one area of performance to meet another area is reviewed. Requirements verification and validation is briefly considered. Testing and its relationship to requirements verification concludes the design process.

Analytical method for establishing indentation rolling resistance

NASA Astrophysics Data System (ADS)

Gładysiewicz, Lech; Konieczna, Martyna

2018-01-01

Belt conveyors are highly reliable machines able to work in special operating conditions. Harsh environment, long distance of transporting and great mass of transported martials are cause of high energy usage. That is why research in the field of belt conveyor transportation nowadays focuses on reducing the power consumption without lowering their efficiency. In this paper, previous methods for testing rolling resistance are described, and new method designed by authors was presented. New method of testing rolling resistance is quite simple and inexpensive. Moreover it allows to conduct the experimental tests of the impact of different parameters on the value of indentation rolling resistance such as core design, cover thickness, ambient temperature, idler travel frequency, or load value as well. Finally results of tests of relationship between rolling resistance and idler travel frequency and between rolling resistance and idler travel speed was presented.

Multispectral Remote Sensing of the Earth and Environment Using KHawk Unmanned Aircraft Systems

NASA Astrophysics Data System (ADS)

Gowravaram, Saket

This thesis focuses on the development and testing of the KHawk multispectral remote sensing system for environmental and agricultural applications. KHawk Unmanned Aircraft System (UAS), a small and low-cost remote sensing platform, is used as the test bed for aerial video acquisition. An efficient image geotagging and photogrammetric procedure for aerial map generation is described, followed by a comprehensive error analysis on the generated maps. The developed procedure is also used for generation of multispectral aerial maps including red, near infrared (NIR) and colored infrared (CIR) maps. A robust Normalized Difference Vegetation index (NDVI) calibration procedure is proposed and validated by ground tests and KHawk flight test. Finally, the generated aerial maps and their corresponding Digital Elevation Models (DEMs) are used for typical application scenarios including prescribed fire monitoring, initial fire line estimation, and tree health monitoring.

Hyper-X: Flight Validation of Hypersonic Airbreathing Technology

NASA Technical Reports Server (NTRS)

Rausch, Vincent L.; McClinton, Charles R.; Crawford, J. Larry

1997-01-01

This paper provides an overview of NASA's focused hypersonic technology program, i.e. the Hyper-X program. This program is designed to move hypersonic, air breathing vehicle technology from the laboratory environment to the flight environment, the last stage preceding prototype development. This paper presents some history leading to the flight test program, research objectives, approach, schedule and status. Substantial experimental data base and concept validation have been completed. The program is concentrating on Mach 7 vehicle development, verification and validation in preparation for wind tunnel testing in 1998 and flight testing in 1999. It is also concentrating on finalization of the Mach 5 and 10 vehicle designs. Detailed evaluation of the Mach 7 vehicle at the flight conditions is nearing completion, and will provide a data base for validation of design methods once flight test data are available.

Developing and testing new smoking measures for the Health Plan Employer Data and Information Set.

PubMed

Pbert, Lori; Vuckovic, Nancy; Ockene, Judith K; Hollis, Jack F; Riedlinger, Karen

2003-04-01

To develop and test items for the Health Plan Employee Data and Information Set (HEDIS) that assess delivery of the full range of provider-delivered tobacco interventions. The authors identified potential items via literature review; items were reviewed by national experts. Face validity of candidate items was tested in focus groups. The final survey was sent to a random sample of 1711 adult primary care patients; the re-test survey was sent to self-identified smokers. The process identified reliable items to capture provider assessment of motivation and provision of assistance and follow-up. One can reliably assess patient self-report of provider delivery of the full range of brief tobacco interventions. Such assessment and feedback to health plans and providers may increase use of evidence-based brief interventions.

Current Research and Potential Applications of the Concealed Information Test: An Overview

PubMed Central

Ben-Shakhar, Gershon

2012-01-01

Research interest in psychophysiological detection of deception has significantly increased since the September 11 terror attack in the USA. In particular, the concealed information test (CIT), designed to detect memory traces that can connect suspects to a certain crime, has been extensively studied. In this paper I will briefly review several psychophysiological detection paradigms that have been studied, with a focus on the CIT. The theoretical background of the CIT, its strength and weaknesses, its potential applications as well as research finings related to its validity (based on a recent meta-analytic study), will be discussed. Several novel research directions, with a focus on factors that may affect CIT detection in realistic settings (e.g., memory for crime details; the effect of emotional stress during crime execution) will be described. Additionally, research focusing on mal-intentions and attempts to detect terror networks using information gathered from groups of suspects using both the standard CIT and the searching CIT will be reviewed. Finally, implications of current research to the actual application of the CIT will be discussed and several recommendations that can enhance the use of the CIT will be made. PMID:23060826

Statistical homogeneity tests applied to large data sets from high energy physics experiments

NASA Astrophysics Data System (ADS)

Trusina, J.; Franc, J.; Kůs, V.

2017-12-01

Homogeneity tests are used in high energy physics for the verification of simulated Monte Carlo samples, it means if they have the same distribution as a measured data from particle detector. Kolmogorov-Smirnov, χ 2, and Anderson-Darling tests are the most used techniques to assess the samples’ homogeneity. Since MC generators produce plenty of entries from different models, each entry has to be re-weighted to obtain the same sample size as the measured data has. One way of the homogeneity testing is through the binning. If we do not want to lose any information, we can apply generalized tests based on weighted empirical distribution functions. In this paper, we propose such generalized weighted homogeneity tests and introduce some of their asymptotic properties. We present the results based on numerical analysis which focuses on estimations of the type-I error and power of the test. Finally, we present application of our homogeneity tests to data from the experiment DØ in Fermilab.

A comparison of rural high school students in Germany with rural Tennessee high school students' mathematics and science achievement

NASA Astrophysics Data System (ADS)

Harding, R. Fredrick

This descriptive study compared the science and mathematics aptitudes and achievement test scores for the final school year students in rural White County and Van Buren County, Tennessee with rural county students in Germany. In accordance with the previous research literature (Stevenson, 2002), German students outperformed U.S. students on The International Trends in Math and Science test (TIMSS). As reform in the U.S. education system has been underway, this study intended to compare German county student final school year performance with White County and Van Buren County (Grade 12) performance in science and mathematics. The entire populations of 176 White and Van Buren Counties senior high final school year students were compared with 120 school final year students from two rural German county high schools. The student responses to identical test and questionnaire items were compared using the t-test statistical analysis. In conclusion after t-test analyses, there was no significant difference (p>.05 level) in student attitudes on the 27 problem achievement and the 35 TIMSS questionnaire items between the sampled population of 120 German students compared with the population of 176 White and Van Buren students. Also, there was no statistically significant difference (p>.05 level) between the German, White, and Van Buren County rural science and math achievement in the TIMSS problem section of the final year test. Based on the research, recommendations to improve U.S. student scores to number one in the world include making changes in teaching methodology in mathematics and science; incorporating pamphlet lessons rather than heavily reliance on textbooks; focusing on problem solving; establishing an online clearinghouse for effective lessons; creating national standards in mathematics and science; matching students' course choices to job aspirations; tracking misbehaving students rather than mainstreaming them into the regular classroom; and designing individual educational plans for every student. Further study and future investigations are recommended from this study to compare White County and Van Buren County Students with other rural county schools in Tennessee, as well as other states. In addition, the Tennessee students' state mandated science and mathematics could be correlated to the TIMMS to identify trends and relationships. Future comparisons of White County and Van Buren County with higher scoring rural Asian students could be done in search of more effective methods of teaching science and mathematics.

Potency testing of veterinary vaccines: the way from in vivo to in vitro.

PubMed

Romberg, Judith; Lang, Stefan; Balks, Elisabeth; Kamphuis, Elisabeth; Duchow, Karin; Loos, Daniela; Rau, Henriette; Motitschke, Andreas; Jungbäck, Carmen

2012-01-01

Current quality control of inactivated animal vaccines still focuses on the potency of final products in a batch-wise manner. Animal welfare concerns as well as scientific considerations have led to the '3Rs-concept' that comprises the refinement of animal procedures, the reduction of animal numbers, and the replacement of animal models. Although the 3Rs-concept has been widely accepted as a fundamental principle, the number of approved alternatives for in vivo tests is still limited. To promote further progress, the international scientific workshop 'Potency Testing of Veterinary Vaccines: The Way from in vivo to in vitro' was held at the Paul-Ehrlich-Institut in Langen, Germany, on 01-03 December 2010. More than 130 participants from industry, academia and regulatory authorities discussed the current state of the 3Rs-concept, examples of its successful implementation as well as still existing hurdles. Special emphasis was laid on the 'consistency approach' that aims to ensure relevant quality attributes of vaccine batches by in vitro analyses during production rather than by in vivo potency tests on the final product. This report provides an overview of the insights gained, including the recommendations produced at the end of the workshop. Copyright © 2011. Published by Elsevier Ltd.. All rights reserved.

It is not known the impact or implications of a study skills class and its effect on high school students in relation to performance on math and science Georgia High School Graduation Test

NASA Astrophysics Data System (ADS)

Smith, Mary E.

The Georgia State Board of Education has put in place requirements that high school students must meet in order to advance to a higher grade level and to achieve credits for graduation. Georgia requires all ninth, tenth, eleventh, and twelfth graders to take an end-of-course test after completing class time for academic core subjects. The student's final grade in the end-of-course test course will be calculated using the course grade as 85% and the end-of-course test score as 15%. The student must have a final course grade of 70 or above to pass the course and to earn credit toward graduation. Students in Georgia are required to take the Georgia High School Graduation Test. The tests consist of five parts, writing, math, science, social studies and language arts. Students must make a minimum score of 500 which indicates the student was proficient in mastering the objectives for that particular section of the test. Not all students finish high school in four years due to obstacles that occur. Tutorial sessions are provided for those that wish to participate. High schools may offer study skills classes for students that need extra help in focusing their attention on academic courses. Study skill courses provide the student with techniques that he or she may find useful in organizing thoughts and procedures that direct the student towards success.

Reliability of physical functioning tests in patients with low back pain: a systematic review.

PubMed

Denteneer, Lenie; Van Daele, Ulrike; Truijen, Steven; De Hertogh, Willem; Meirte, Jill; Stassijns, Gaetane

2018-01-01

The aim of this study was to provide a comprehensive overview of physical functioning tests in patients with low back pain (LBP) and to investigate their reliability. A systematic computerized search was finalized in four different databases on June 24, 2017: PubMed, Web of Science, Embase, and MEDLINE. Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines were followed during all stages of this review. Clinical studies that investigate the reliability of physical functioning tests in patients with LBP were eligible. The methodological quality of the included studies was assessed with the use of the Consensus-based Standards for the selection of health Measurement Instruments (COSMIN) checklist. To come to final conclusions on the reliability of the identified clinical tests, the current review assessed three factors, namely, outcome assessment, methodological quality, and consistency of description. A total of 20 studies were found eligible and 38 clinical tests were identified. Good overall test-retest reliability was concluded for the extensor endurance test (intraclass correlation coefficient [ICC]=0.93-0.97), the flexor endurance test (ICC=0.90-0.97), the 5-minute walking test (ICC=0.89-0.99), the 50-ft walking test (ICC=0.76-0.96), the shuttle walk test (ICC=0.92-0.99), the sit-to-stand test (ICC=0.91-0.99), and the loaded forward reach test (ICC=0.74-0.98). For inter-rater reliability, only one test, namely, the Biering-Sörensen test (ICC=0.88-0.99), could be concluded to have an overall good inter-rater reliability. None of the identified clinical tests could be concluded to have a good intrarater reliability. Further investigation should focus on a better overall study methodology and the use of identical protocols for the description of clinical tests. The assessment of reliability is only a first step in the recommendation process for the use of clinical tests. In future research, the identified clinical tests in the current review should be further investigated for validity. Only when these clinimetric properties of a clinical test have been thoroughly investigated can a final conclusion regarding the clinical and scientific use of the identified tests be made. Copyright © 2017 Elsevier Inc. All rights reserved.

Development of Guidelines for In-Situ Repair of SLS-Class Composite Flight Hardware

NASA Technical Reports Server (NTRS)

Weber, Thomas P., Jr.; Cox, Sarah B.

2018-01-01

The purpose of composite repair development at KSC (John F. Kennedy Space Center) is to provide support to the CTE (Composite Technology for Exploration) project. This is a multi-space center effort with the goal of developing bonded joint technology for SLS (Space Launch System) -scale composite hardware. At KSC, effective and efficient repair processes need to be developed to allow for any potential damage to composite components during transport or launch preparation. The focus of the composite repair development internship during the spring of 2018 was on the documentation of repair processes and requirements for process controls based on techniques developed through hands-on work with composite test panels. Three composite test panels were fabricated for the purpose of repair and surface preparation testing. The first panel included a bonded doubler and was fabricated to be damaged and repaired. The second and third panels were both fabricated to be cut into lap-shear samples to test the strength of bond of different surface preparation techniques. Additionally, jointed composite test panels were impacted at MSFC (Marshall Space Flight Center) and analyzed for damage patterns. The observations after the impact tests guided the repair procedure at KSC to focus on three repair methods. With a finalized repair plan in place, future work will include the strength testing of different surface preparation techniques, demonstration of repair methods, and repair of jointed composite test panels being impacted at MSFC.

Developing and testing lay literature about breast cancer screening for African American women.

PubMed

Coleman, Elizabeth Ann; Coon, Sharon; Mohrmann, Carolyn; Hardin, Susan; Stewart, Beth; Gibson, Regina Shoate; Cantrell, Mary; Lord, Janet; Heard, Jeanne

2003-01-01

Written materials about breast cancer screening for African American women with low literacy skills are needed. Available materials were not at or below third-grade reading levels, were not culturally sensitive, and were not accurate in illustrating correct breast self-examination (BSE) techniques. Focus groups representing the target population helped the authors design a pamphlet describing how to perform BSE and a motivational picture book to help women overcome barriers to screening. The authors chose a food theme for the cover of the pamphlet written at a third-grade level and suggested a photographic version. In the motivational book, two women address barriers to screening and replace myths and fears with facts and actions. Data from 162 women showed that they learned from both the photographic and illustrated versions. Women in the photographic group found significantly more lumps in the silicone models, so the authors chose that version to use in final testing. Finally, nurses pretested a group of patients before they reviewed the materials and post-tested another group after they reviewed them. The group who had reviewed the materials had greater knowledge of and intent to follow the guidelines and received higher scores on BSE techniques.

High-temperature Strain Sensor and Mounting Development

NASA Technical Reports Server (NTRS)

Williams, W. Dan; Lei, Jih-Fen; Reardon, Lawrence F.; Krake, Keith; Lemcoe, M. M.; Holmes, Harlan K.; Moore, Thomas C., Sr.

1996-01-01

This report describes Government Work Package Task 29 (GWP29), whose purpose was to develop advanced strain gage technology in support of the National Aerospace Plane (NASP) Program. The focus was on advanced resistance strain gages with a temperature range from room temperature to 2000 F (1095 C) and on methods for reliably attaching these gages to the various materials anticipated for use in the NASP program. Because the NASP program required first-cycle data, the installed gages were not prestabilized or heat treated on the test coupons before first-cycle data were recorded. NASA Lewis Research Center, the lead center for GWP29, continued its development of the palladium-chromium gage; NASA Langley Research Center investigated a new concept gage using Kanthal A1; and the NASA Dryden Flight Research Center chose the well-known BCL-3 iron-chromium-aluminum gage. Each center then tested all three gages. The parameters investigated were apparent strain, drift strain, and gage factor as a function of temperature, plus gage size and survival rate over the test period. Although a significant effort was made to minimize the differences in test equipment between the three test sites (e.g., the same hardware and software were used for final data processing), the center employed different data acquisition systems and furnace configurations so that some inherent differences may be evident in the final results.

An electrostatic deceleration lens for highly charged ions.

PubMed

Rajput, J; Roy, A; Kanjilal, D; Ahuja, R; Safvan, C P

2010-04-01

The design and implementation of a purely electrostatic deceleration lens used to obtain beams of highly charged ions at very low energies is presented. The design of the lens is such that it can be used with parallel as well as diverging incoming beams and delivers a well focused low energy beam at the target. In addition, tuning of the final energy of the beam over a wide range (1 eV/q to several hundred eV/q, where q is the beam charge state) is possible without any change in hardware configuration. The deceleration lens was tested with Ar(8+), extracted from an electron cyclotron resonance ion source, having an initial energy of 30 keV/q and final energies as low as 70 eV/q have been achieved.

Is academic buoyancy anything more than adaptive coping?

PubMed

Putwain, David W; Connors, Liz; Symes, Wendy; Douglas-Osborn, Erica

2012-05-01

Academic buoyancy refers to a positive, constructive, and adaptive response to the types of challenges and setbacks experienced in a typical and everyday academic setting. In this project we examined whether academic buoyancy explained any additional variance in test anxiety over and above that explained by coping. Two hundred and ninety-eight students in their final two years of compulsory schooling completed self-report measures of academic buoyancy, coping, and test anxiety. Results suggested that buoyancy was inversely related to test anxiety and unrelated to coping. With the exception of test-irrelevant thoughts, test anxiety was positively related to avoidance coping and social support. Test-irrelevant thoughts were inversely related to task focus, unrelated to social support, and positively related to avoidance. A hierarchical regression analysis showed that academic buoyancy explained a significant additional proportion of variance in test anxiety when the variance for coping had already been accounted for. These findings suggest that academic buoyancy can be considered as a distinct construct from that of adaptive coping.

Degree of host susceptibility in the initial disease outbreak influences subsequent epidemic spread

PubMed Central

Severns, Paul M.; Estep, Laura K.; Sackett, Kathryn E.; Mundt, Christopher C.

2014-01-01

Summary Disease epidemics typically begin as an outbreak of a relatively small, spatially explicit population of infected individuals (focus), in which disease prevalence increases and rapidly spreads into the uninfected, at-risk population. Studies of epidemic spread typically address factors influencing disease spread through the at-risk population, but the initial outbreak may strongly influence spread of the subsequent epidemic.We initiated wheat stripe rust Puccinia striiformis f. sp. tritici epidemics to assess the influence of the focus on final disease prevalence when the degree of disease susceptibility differed between the at-risk and focus populations.When the focus/at-risk plantings consisted of partially genetic resistant and susceptible cultivars, final disease prevalence was statistically indistinguishable from epidemics produced by the focus cultivar in monoculture. In these experimental epidemics, disease prevalence was not influenced by the transition into an at-risk population that differed in disease susceptibility. Instead, the focus appeared to exert a dominant influence on the subsequent epidemic.Final disease prevalence was not consistently attributable to either the focus or the at-risk population when focus/at-risk populations were planted in a factorial set-up with a mixture (~28% susceptible and 72% resistant) and susceptible individuals. In these experimental epidemics, spatial heterogeneity in disease susceptibility within the at-risk population appeared to counter the dominant influence of the focus.Cessation of spore production from the focus (through fungicide/glyphosate application) after 1.3 generations of stripe rust spread did not reduce final disease prevalence, indicating that the focus influence on disease spread is established early in the epidemic.Synthesis and applications. Our experiments indicated that outbreak conditions can be highly influential on epidemic spread, even when disease resistance in the at-risk population is greater than that of the focus. Disease control treatments administered shortly after the initial outbreak within the focus may either prevent an epidemic from occurring or reduce its severity. PMID:25512677

Apocalypse...now? Molecular epidemiology, predictive genetic tests, and social communication of genetic contents.

PubMed

Castiel, L D

1999-01-01

The author analyzes the underlying theoretical aspects in the construction of the molecular watershed of epidemiology and the concept of genetic risk, focusing on issues raised by contemporary reality: new technologies, globalization, proliferation of communications strategies, and the dilution of identity matrices. He discusses problems pertaining to the establishment of such new interdisciplinary fields as molecular epidemiology and molecular genetics. Finally, he analyzes the repercussions of the social communication of genetic content, especially as related to predictive genetic tests and cloning of animals, based on triumphal, deterministic metaphors sustaining beliefs relating to the existence and supremacy of concepts such as 'purity', 'essence', and 'unification' of rational, integrated 'I's/egos'.

An Adaptive Altitude Information Fusion Method for Autonomous Landing Processes of Small Unmanned Aerial Rotorcraft

PubMed Central

Lei, Xusheng; Li, Jingjing

2012-01-01

This paper presents an adaptive information fusion method to improve the accuracy and reliability of the altitude measurement information for small unmanned aerial rotorcraft during the landing process. Focusing on the low measurement performance of sensors mounted on small unmanned aerial rotorcraft, a wavelet filter is applied as a pre-filter to attenuate the high frequency noises in the sensor output. Furthermore, to improve altitude information, an adaptive extended Kalman filter based on a maximum a posteriori criterion is proposed to estimate measurement noise covariance matrix in real time. Finally, the effectiveness of the proposed method is proved by static tests, hovering flight and autonomous landing flight tests. PMID:23201993

Investigation of bus transit schedule behavior modeling using advanced techniques

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kalaputapu, R.; Demetsky, M.J.

This research focused on investigating the application of artificial neural networks (ANN) and the Box-Jenkins technique for developing and testing schedule behavior models using data obtained for a test route from Tidewater Regional Transit`s AVL system. The three ANN architectures investigated were: Feedforward Network, Elman Network and Jordan Network. In addition, five different model structures were investigated. The time-series methodology was adopted for developing the schedule behavior models. Finally, the role of a schedule behavior model within the framework of an intelligent transit management system is defined and the potential utility of the schedule behavior model is discussed using anmore » example application.« less

Cavity beam position monitor system for the Accelerator Test Facility 2

NASA Astrophysics Data System (ADS)

Kim, Y. I.; Ainsworth, R.; Aryshev, A.; Boogert, S. T.; Boorman, G.; Frisch, J.; Heo, A.; Honda, Y.; Hwang, W. H.; Huang, J. Y.; Kim, E.-S.; Kim, S. H.; Lyapin, A.; Naito, T.; May, J.; McCormick, D.; Mellor, R. E.; Molloy, S.; Nelson, J.; Park, S. J.; Park, Y. J.; Ross, M.; Shin, S.; Swinson, C.; Smith, T.; Terunuma, N.; Tauchi, T.; Urakawa, J.; White, G. R.

2012-04-01

The Accelerator Test Facility 2 (ATF2) is a scaled demonstrator system for final focus beam lines of linear high energy colliders. This paper describes the high resolution cavity beam position monitor (BPM) system, which is a part of the ATF2 diagnostics. Two types of cavity BPMs are used, C-band operating at 6.423 GHz, and S-band at 2.888 GHz with an increased beam aperture. The cavities, electronics, and digital processing are described. The resolution of the C-band system with attenuators was determined to be approximately 250 nm and 1μm for the S-band system. Without attenuation the best recorded C-band cavity resolution was 27 nm.

Practicing more retrieval routes leads to greater memory retention.

PubMed

Zheng, Jun; Zhang, Wei; Li, Tongtong; Liu, Zhaomin; Luo, Liang

2016-09-01

A wealth of research has shown that retrieval practice plays a significant role in improving memory retention. The current study focused on one simple yet rarely examined question: would repeated retrieval using two different retrieval routes or using the same retrieval route twice lead to greater long-term memory retention? Participants elaborately learned 22 Japanese-Chinese translation word pairs using two different mediators. Half an hour after the initial study phase, the participants completed two retrieval sessions using either one mediator (Tm1Tm1) or two different mediators (Tm1Tm2). On the final test, which was performed 1week after the retrieval practice phase, the participants received only the cue with a request to report the mediator (M1 or M2) followed by the target (Experiment 1) or only the mediator (M1 or M2) with a request to report the target (Experiment 2). The results of Experiment 1 indicated that the participants who practiced under the Tm1Tm2 condition exhibited greater target retention than those who practiced under the Tm1Tm1 condition. This difference in performance was due to the significant disadvantage in mediator retrieval and decoding of the unpracticed mediator under the Tm1Tm1 condition. Although mediators were provided to participants on the final test in Experiment 2, decoding of the unpracticed mediators remained less effective than decoding of the practiced mediators. We conclude that practicing multiple retrieval routes leads to greater memory retention than focusing on a single retrieval route. Thus, increasing retrieval variability during repeated retrieval practice indeed significantly improves long-term retention in a delay test. Copyright © 2016 Elsevier B.V. All rights reserved.

Spherical primary optical telescope (SPOT) segments

NASA Astrophysics Data System (ADS)

Hall, Christopher; Hagopian, John; DeMarco, Michael

2012-09-01

The spherical primary optical telescope (SPOT) project is an internal research and development program at NASA Goddard Space Flight Center. The goals of the program are to develop a robust and cost effective way to manufacture spherical mirror segments and demonstrate a new wavefront sensing approach for continuous phasing across the segmented primary. This paper focuses on the fabrication of the mirror segments. Significant cost savings were achieved through the design, since it allowed the mirror segments to be cast rather than machined from a glass blank. Casting was followed by conventional figuring at Goddard Space Flight Center. After polishing, the mirror segments were mounted to their composite assemblies. QED Technologies used magnetorheological finishing (MRF®) for the final figuring. The MRF process polished the mirrors while they were mounted to their composite assemblies. Each assembly included several magnetic invar plugs that extended to within an inch of the face of the mirror. As part of this project, the interaction between the MRF magnetic field and invar plugs was evaluated. By properly selecting the polishing conditions, MRF was able to significantly improve the figure of the mounted segments. The final MRF figuring demonstrates that mirrors, in the mounted configuration, can be polished and tested to specification. There are significant process capability advantes due to polishing and testing the optics in their final, end-use assembled state.

Examination of food waste co-digestion to manage the peak in energy demand at wastewater treatment plants.

PubMed

Lensch, D; Schaum, C; Cornel, P

2016-01-01

Many digesters in Germany are not operated at full capacity; this offers the opportunity for co-digestion. Within this research the potentials and limits of a flexible and adapted sludge treatment are examined with a focus on the digestion process with added food waste as co-substrate. In parallel, energy data from a municipal wastewater treatment plant (WWTP) are analysed and lab-scale semi-continuous and batch digestion tests are conducted. Within the digestion tests, the ratio of sewage sludge to co-substrate was varied. The final methane yields show the high potential of food waste: the higher the amount of food waste the higher the final yield. However, the conversion rates directly after charging demonstrate better results by charging 10% food waste instead of 20%. Finally, these results are merged with the energy data from the WWTP. As an illustration, the load required to cover base loads as well as peak loads for typical daily variations of the plant's energy demand are calculated. It was found that 735 m³ raw sludge and 73 m³ of a mixture of raw sludge and food waste is required to cover 100% of the base load and 95% of the peak load.

Photocathode Optimization for a Dynamic Transmission Electron Microscope: Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ellis, P; Flom, Z; Heinselman, K

2011-08-04

The Dynamic Transmission Electron Microscope (DTEM) team at Harvey Mudd College has been sponsored by LLNL to design and build a test setup for optimizing the performance of the DTEM's electron source. Unlike a traditional TEM, the DTEM achieves much faster exposure times by using photoemission from a photocathode to produce electrons for imaging. The DTEM team's work is motivated by the need to improve the coherence and current density of the electron cloud produced by the electron gun in order to increase the image resolution and contrast achievable by DTEM. The photoemission test setup is nearly complete and themore » team will soon complete baseline tests of electron gun performance. The photoemission laser and high voltage power supply have been repaired; the optics path for relaying the laser to the photocathode has been finalized, assembled, and aligned; the internal setup of the vacuum chamber has been finalized and mostly implemented; and system control, synchronization, and data acquisition has been implemented in LabVIEW. Immediate future work includes determining a consistent alignment procedure to place the laser waist on the photocathode, and taking baseline performance measurements of the tantalum photocathode. Future research will examine the performance of the electron gun as a function of the photoemission laser profile, the photocathode material, and the geometry and voltages of the accelerating and focusing components in the electron gun. This report presents the team's progress and outlines the work that remains.« less

Advanced in-duct sorbent injection for SO{sub 2} control. Final technical report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stouffer, M.R.; Withium, J.A.; Rosenhoover, W.A.

1994-12-01

The objective of this research project was to develop a second generation duct sorbent injection technology as a cost-effective compliance option for the 1990 Clean Air Act Amendments. Research and development work was focused on the Advanced Coolside process, which showed the potential for exceeding the original performance targets of 90% SO{sub 2} removal and 60% sorbent utilization. Process development was conducted in a 1000 acfm pilot plant. The pilot plant testing showed that the Advanced Coolside process can achieve 90% SO{sub 2} removal at sorbent utilizations up to 75%. The testing also showed that the process has the potentialmore » to achieve very high removal efficiency (90 to >99%). By conducting conceptual process design and economic evaluations periodically during the project, development work was focused on process design improvements which substantially lowered process capital and operating costs, A final process economic study projects capital costs less than one half of those for limestone forced oxidation wet FGD. Projected total SO{sub 2} control cost is about 25% lower than wet FGD for a 260 MWe plant burning a 2.5% sulfur coal. A waste management study showed the acceptability of landfill disposal; it also identified a potential avenue for by-product utilization which should be further investigated. Based on the pilot plant performance and on the above economic projections, future work to scale up the Advanced Coolside process is recommended.« less

Dispatches from the front: emergency medicine teachers' perceptions of competency-based education.

PubMed

Bandiera, Glen; Lendrum, David

2011-05-01

Controversy exists regarding the applicability of competency-based education during clinical rotations in emergency medicine (EM). Little has been written about the perceptions of front-line teachers regarding one such competency-based education paradigm, the CanMEDS framework. We undertook to determine 1) what perceptions exist among front-line teachers at two academic health science emergency departments (EDs) regarding the use of the CanMEDS roles to frame what residents should learn on ED rotations and 2) how those same teachers envision practically incorporating the CanMEDS roles into feedback provided to residents. Teachers at two sites volunteered for a semistructured focus group study. Focus groups were moderated by an experienced qualitative researcher, and verbatim transcriptions were coded by two independent reviewers. The codes were merged into final themes. The final focus group was used to further explore issues raised and test assumptions made in the preceding groups. In five focus groups involving 21 participants, the Medical Expert and Professional roles were seen as most relevant to an EM rotation, whereas the Health Advocate, Manager, Scholar, and Collaborator roles were least relevant. On further exploration, however, faculty identified highly relevant components of each role that they could envision teaching in an ED. Participants also felt that the framework helped highlight the breadth of physician competencies and provided structure for teaching and feedback. EM faculty find the CanMEDS framework helpful for structuring teaching and learning and that many elements of the roles, when defined, are feasible to integrate into a clinical rotation.

Considerations for acoustic emission monitoring of spherical Kevlar/epoxy composite pressure vessels

NASA Technical Reports Server (NTRS)

Hamstad, M. A.; Patterson, R. G.

1977-01-01

We are continuing to research the applications of acoustic emission testing for predicting burst pressure of filament-wound Kevlar 49/epoxy pressure vessels. This study has focused on three specific areas. The first area involves development of an experimental technique and the proper instrumentation to measure the energy given off by the acoustic emission transducer per acoustic emission burst. The second area concerns the design of a test fixture in which to mount the composite vessel so that the acoustic emission transducers are held against the outer surface of the composite. Included in this study area is the calibration of the entire test setup including couplant, transducer, electronics, and the instrument measuring the energy per burst. In the third and final area of this study, we consider the number, location, and sensitivity of the acoustic emission transducers used for proof testing composite pressure vessels.

Post-analytical Issues in Hemostasis and Thrombosis Testing.

PubMed

Favaloro, Emmanuel J; Lippi, Giuseppe

2017-01-01

Analytical concerns within hemostasis and thrombosis testing are continuously decreasing. This is essentially attributable to modern instrumentation, improvements in test performance and reliability, as well as the application of appropriate internal quality control and external quality assurance measures. Pre-analytical issues are also being dealt with in some newer instrumentation, which are able to detect hemolysis, icteria and lipemia, and, in some cases, other issues related to sample collection such as tube under-filling. Post-analytical issues are generally related to appropriate reporting and interpretation of test results, and these are the focus of the current overview, which provides a brief description of these events, as well as guidance for their prevention or minimization. In particular, we propose several strategies for improved post-analytical reporting of hemostasis assays and advise that this may provide the final opportunity to prevent serious clinical errors in diagnosis.

Assessing student understanding of measurement and uncertainty

NASA Astrophysics Data System (ADS)

Jirungnimitsakul, S.; Wattanakasiwich, P.

2017-09-01

The objectives of this study were to develop and assess student understanding of measurement and uncertainty. A test has been adapted and translated from the Laboratory Data Analysis Instrument (LDAI) test, consists of 25 questions focused on three topics including measures of central tendency, experimental errors and uncertainties, and fitting regression lines. The test was evaluated its content validity by three physics experts in teaching physics laboratory. In the pilot study, Thai LDAI was administered to 93 freshmen enrolled in a fundamental physics laboratory course. The final draft of the test was administered to three groups—45 freshmen taking fundamental physics laboratory, 16 sophomores taking intermediated physics laboratory and 21 juniors taking advanced physics laboratory at Chiang Mai University. As results, we found that the freshmen had difficulties in experimental errors and uncertainties. Most students had problems with fitting regression lines. These results will be used to improve teaching and learning physics laboratory for physics students in the department.

The Recommendations for Linear Measurement Techniques on the Measurements of Nonlinear System Parameters of a Joint.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, Scott A; Catalfamo, Simone; Brake, Matthew R. W.

2017-01-01

In the study of the dynamics of nonlinear systems, experimental measurements often convolute the response of the nonlinearity of interest and the effects of the experimental setup. To reduce the influence of the experimental setup on the deduction of the parameters of the nonlinearity, the response of a mechanical joint is investigated under various experimental setups. These experiments first focus on quantifying how support structures and measurement techniques affect the natural frequency and damping of a linear system. The results indicate that support structures created from bungees have negligible influence on the system in terms of frequency and damping ratiomore » variations. The study then focuses on the effects of the excitation technique on the response for a linear system. The findings suggest that thinner stingers should not be used, because under the high force requirements the stinger bending modes are excited adding unwanted torsional coupling. The optimal configuration for testing the linear system is then applied to a nonlinear system in order to assess the robustness of the test configuration. Finally, recommendations are made for conducting experiments on nonlinear systems using conventional/linear testing techniques.« less

Institute for High Heat Flux Removal (IHHFR). Phases I, II, and III

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boyd, Ronald D.

2014-08-31

The IHHFR focused on interdisciplinary applications as it relates to high heat flux engineering issues and problems which arise due to engineering systems being miniaturized, optimized, or requiring increased high heat flux performance. The work in the IHHFR focused on water as a coolant and includes: (1) the development, design, and construction of the high heat flux flow loop and facility; (2) test section development, design, and fabrication; and, (3) single-side heat flux experiments to produce 2-D boiling curves and 3-D conjugate heat transfer measurements for single-side heated test sections. This work provides data for comparisons with previously developed andmore » new single-side heated correlations and approaches that address the single-side heated effect on heat transfer. In addition, this work includes the addition of single-side heated circular TS and a monoblock test section with a helical wire insert. Finally, the present work includes: (1) data base expansion for the monoblock with a helical wire insert (only for the latter geometry), (2) prediction and verification using finite element, (3) monoblock model and methodology development analyses, and (4) an alternate model development for a hypervapotron and related conjugate heat transfer controlling parameters.« less

Test validity and performance validity: considerations in providing a framework for development of an ability-focused neuropsychological test battery.

PubMed

Larrabee, Glenn J

2014-11-01

Literature on test validity and performance validity is reviewed to propose a framework for specification of an ability-focused battery (AFB). Factor analysis supports six domains of ability: first, verbal symbolic; secondly, visuoperceptual and visuospatial judgment and problem solving; thirdly, sensorimotor skills; fourthly, attention/working memory; fifthly, processing speed; finally, learning and memory (which can be divided into verbal and visual subdomains). The AFB should include at least three measures for each of the six domains, selected based on various criteria for validity including sensitivity to presence of disorder, sensitivity to severity of disorder, correlation with important activities of daily living, and containing embedded/derived measures of performance validity. Criterion groups should include moderate and severe traumatic brain injury, and Alzheimer's disease. Validation groups should also include patients with left and right hemisphere stroke, to determine measures sensitive to lateralized cognitive impairment and so that the moderating effects of auditory comprehension impairment and neglect can be analyzed on AFB measures. © The Author 2014. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

The cobas® 6800/8800 System: a new era of automation in molecular diagnostics.

PubMed

Cobb, Bryan; Simon, Christian O; Stramer, Susan L; Body, Barbara; Mitchell, P Shawn; Reisch, Natasa; Stevens, Wendy; Carmona, Sergio; Katz, Louis; Will, Stephen; Liesenfeld, Oliver

2017-02-01

Molecular diagnostics is a key component of laboratory medicine. Here, the authors review key triggers of ever-increasing automation in nucleic acid amplification testing (NAAT) with a focus on specific automated Polymerase Chain Reaction (PCR) testing and platforms such as the recently launched cobas® 6800 and cobas® 8800 Systems. The benefits of such automation for different stakeholders including patients, clinicians, laboratory personnel, hospital administrators, payers, and manufacturers are described. Areas Covered: The authors describe how molecular diagnostics has achieved total laboratory automation over time, rivaling clinical chemistry to significantly improve testing efficiency. Finally, the authors discuss how advances in automation decrease the development time for new tests enabling clinicians to more readily provide test results. Expert Commentary: The advancements described enable complete diagnostic solutions whereby specific test results can be combined with relevant patient data sets to allow healthcare providers to deliver comprehensive clinical recommendations in multiple fields ranging from infectious disease to outbreak management and blood safety solutions.

Software architecture and engineering for patient records: current and future.

PubMed

Weng, Chunhua; Levine, Betty A; Mun, Seong K

2009-05-01

During the "The National Forum on the Future of the Defense Health Information System," a track focusing on "Systems Architecture and Software Engineering" included eight presenters. These presenters identified three key areas of interest in this field, which include the need for open enterprise architecture and a federated database design, net centrality based on service-oriented architecture, and the need for focus on software usability and reusability. The eight panelists provided recommendations related to the suitability of service-oriented architecture and the enabling technologies of grid computing and Web 2.0 for building health services research centers and federated data warehouses to facilitate large-scale collaborative health care and research. Finally, they discussed the need to leverage industry best practices for software engineering to facilitate rapid software development, testing, and deployment.

Ultrasonic brain therapy: First trans-skull in vivo experiments on sheep using adaptive focusing

NASA Astrophysics Data System (ADS)

Pernot, Mathieu; Aubry, Jean-Francois; Tanter, Michael; Fink, Mathias; Boch, Anne-Laure; Kujas, Michèle

2004-05-01

A high-power prototype dedicated to trans-skull therapy has been tested in vivo on 20 sheep. The array is made of 200 high-power transducers working at 1-MHz central and is able to reach 260 bars at focus in water. An echographic array connected to a Philips HDI 1000 system has been inserted in the therapeutic array in order to perform real-time monitoring of the treatment. A complete craniotomy has been performed on half of the treated animal models in order to get a reference model. On the other animals, a minimally invasive surgery has been performed thanks to a time-reversal experiment: a hydrophone was inserted at the target inside the brain thanks to a 1-mm2 craniotomy. A time-reversal experiment was then conducted through the skull bone with the therapeutic array to treat the targeted point. For all the animals a specified region around the target was treated thanks to electronic beam steering. Animals were finally divided into three groups and sacrificed, respectively, 0, 1, and 2 weeks after treatment. Finally, histological examination confirmed tissue damage. These in vivo experiments highlight the strong potential of high-power time-reversal technology.

Integrated Data Collection Analysis (IDCA) Program - Final Review September 12, 2012 at DHS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sandstrom, Mary M.; Brown, Geoffrey W.; Warner, Kirstin F.

The Integrated Data Collection Analysis (IDCA) program conducted a final program review at the Department of Homeland Security on September 12, 2012. The review was focused on the results of the program over the complete performance period. A summary presentation delineating the accomplished tasks started the meeting, followed by technical presentations on various issues that arose during the performance period. The presentations were completed with a statistical evaluation of the testing results from all the participants in the IDCA Proficiency Test study. The meeting closed with a discussion of potential sources of funding for continuing work to resolve some ofmore » these technical issues. This effort, funded by the Department of Homeland Security (DHS), put the issues of safe handling of these materials in perspective with standard military explosives. The study added Small-Scale Safety and Thermal (SSST) testing results for a broad suite of different HMEs to the literature, and suggested new guidelines and methods to develop safe handling practices for HMEs. Each participating testing laboratory used identical test materials and preparation methods wherever possible. Note, however, the test procedures differ among the laboratories. The results were compared among the laboratories and then compared to historical data from various sources. The testing performers involved were Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory (LANL), Naval Surface Warfare Center, Indian Head Division (NSWC IHD), Sandia National Laboratories (SNL), and Air Force Research Laboratory, Tyndall AFB (AFRL/RXQL). These tests were conducted as a proficiency study in order to establish some consistency in test protocols, procedures, and experiments and to compare results when these testing variables cannot be made consistent.« less

Differences in lupus anticoagulant final conclusion through clotting time or Rosner index for mixing test interpretation.

PubMed

Depreter, Barbara; Devreese, Katrien M J

2016-09-01

Lupus anticoagulant (LAC) testing includes a screening, mixing and confirmation step. Although recently published guidelines on LAC testing are a useful step towards standardization, a lack of consensus remains whether to express mixing tests in clotting time (CT) or index of circulating anticoagulant (ICA). The influence of anticoagulant therapy, e.g. vitamin K antagonists (VKA) or direct oral anticoagulants (DOAC) on both methods of interpretation remains to be investigated. The objective of this study was to contribute to a simplification and standardization of the LAC three-step interpretation on the level of the mixing test. Samples from 148 consecutive patients with LAC request and prolonged screening step, and 77 samples from patients non-suspicious for LAC treated with VKA (n=37) or DOAC (n=30) were retrospectively evaluated. An activated partial thromboplastin time (aPTT) and dilute Russell's viper venom time (dRVVT) were used for routine LAC testing. The supplemental anticoagulant samples were tested with dRVVT only. We focused on the interpretation differences for mixing tests expressed as CT or ICA and compared the final LAC conclusion within each distinct group of concordant and discordant mixing test results. Mixing test interpretation by CT resulted in 10 (dRVVT) and 16 (aPTT) more LAC positive patients compared to interpretation with ICA. Isolated prolonged dRVVT screen mix ICA results were exclusively observed in samples from VKA-treated patients without suspicion for LAC. We recommend using CT in respect to the 99th percentile cut-off for interpretation of mixing steps in order to reach the highest sensitivity and specificity in LAC detection.

Reconceptualising the external validity of discrete choice experiments.

PubMed

Lancsar, Emily; Swait, Joffre

2014-10-01

External validity is a crucial but under-researched topic when considering using discrete choice experiment (DCE) results to inform decision making in clinical, commercial or policy contexts. We present the theory and tests traditionally used to explore external validity that focus on a comparison of final outcomes and review how this traditional definition has been empirically tested in health economics and other sectors (such as transport, environment and marketing) in which DCE methods are applied. While an important component, we argue that the investigation of external validity should be much broader than a comparison of final outcomes. In doing so, we introduce a new and more comprehensive conceptualisation of external validity, closely linked to process validity, that moves us from the simple characterisation of a model as being or not being externally valid on the basis of predictive performance, to the concept that external validity should be an objective pursued from the initial conceptualisation and design of any DCE. We discuss how such a broader definition of external validity can be fruitfully used and suggest innovative ways in which it can be explored in practice.

Collaboration and critical thinking in an online chemistry environment

NASA Astrophysics Data System (ADS)

Kershisnik, Elizabeth Irene

The purpose of this dissertation was to examine collaboration and student's critical thinking and cognitive achievement within online chemistry courses. This quantitative study focused on the apparent lack of research relating collaboration and critical thinking in online science courses. Collaboration was determined using the small group collaboration model coding scheme, which examined student postings in asynchronous discussion forums for quantity, equality, and shareness. Critical thinking was measured using the chemistry concept reasoning test, the online self-diagnostic test, and also asynchronous student homework discussion postings that were coded using the community of inquiry cognitive presence indicators. Finally cognitive achievement was determined using quiz scores and the student's final grade. Even though no significant findings were revealed in this exploratory quasi-experimental study, this research did add to the educational technology knowledge base since very few studies have investigated the chemistry discipline in an online environment. Continued research in this area is vital to understanding how critical thinking progresses, how it can be assessed, and what factors in the classroom, be it virtual or face-to-face, have the greatest effect on critical thinking.

Immunotherapy: a new standard of care in thoracic malignancies? A summary of the European Respiratory Society research seminar of the Thoracic Oncology Assembly.

PubMed

Costantini, Adrien; Grynovska, Marta; Lucibello, Francesca; Moisés, Jorge; Pagès, Franck; Tsao, Ming S; Shepherd, Frances A; Bouchaab, Hasna; Garassino, Marina; Aerts, Joachim G J V; Mazières, Julien; Mondini, Michele; Berghmans, Thierry; Meert, Anne-Pascale; Cadranel, Jacques

2018-02-01

In May 2017, the second European Respiratory Society research seminar of the Thoracic Oncology Assembly entitled "Immunotherapy, a new standard of care in thoracic malignancies?" was held in Paris, France. This seminar provided an opportunity to review the basis of antitumour immunity and to explain how immune checkpoint inhibitors (ICIs) work. The main therapeutic trials that have resulted in marketing authorisations for use of ICIs in lung cancer were reported. A particular focus was on the toxicity of these new molecules in relation to their immune-related adverse events. The need for biological selection, currently based on immunohistochemistry testing to identify the tumour expression of programmed death ligand (PD-L)1, was stressed, as well as the need to harmonise PD-L1 testing and techniques. Finally, sessions were dedicated to the combination of ICIs and radiotherapy and the place of ICIs in nonsmall cell lung cancer with oncogenic addictions. Finally, an important presentation was dedicated to the future of antitumour vaccination and of all ongoing trials in thoracic oncology. Copyright ©ERS 2018.

Focus measure method based on the modulus of the gradient of the color planes for digital microscopy

NASA Astrophysics Data System (ADS)

Hurtado-Pérez, Román; Toxqui-Quitl, Carina; Padilla-Vivanco, Alfonso; Aguilar-Valdez, J. Félix; Ortega-Mendoza, Gabriel

2018-02-01

The modulus of the gradient of the color planes (MGC) is implemented to transform multichannel information to a grayscale image. This digital technique is used in two applications: (a) focus measurements during autofocusing (AF) process and (b) extending the depth of field (EDoF) by means of multifocus image fusion. In the first case, the MGC procedure is based on an edge detection technique and is implemented in over 15 focus metrics that are typically handled in digital microscopy. The MGC approach is tested on color images of histological sections for the selection of in-focus images. An appealing attribute of all the AF metrics working in the MGC space is their monotonic behavior even up to a magnification of 100×. An advantage of the MGC method is its computational simplicity and inherent parallelism. In the second application, a multifocus image fusion algorithm based on the MGC approach has been implemented on graphics processing units (GPUs). The resulting fused images are evaluated using a nonreference image quality metric. The proposed fusion method reveals a high-quality image independently of faulty illumination during the image acquisition. Finally, the three-dimensional visualization of the in-focus image is shown.

Minimally Invasive Surgery Survey: A Survey of Surgical Team Members' Perceptions for Successful Minimally Invasive Surgery.

PubMed

Yurteri-Kaplan, Ladin A; Andriani, Leslie; Kumar, Anagha; Saunders, Pamela A; Mete, Mihriye M; Sokol, Andrew I

To develop a valid and reliable survey to measure surgical team members' perceptions regarding their institution's requirements for successful minimally invasive surgery (MIS). Questionnaire development and validation study (Canadian Task Force classification II-2). Three hospital types: rural, urban/academic, and community/academic. Minimally invasive staff (team members). Development and validation of a minimally invasive surgery survey (MISS). Using the Safety Attitudes questionnaire as a guide, we developed questions assessing study participants' attitudes regarding the requirements for successful MIS. The questions were closed-ended and responses based on a 5-point Likert scale. The large pool of questions was then given to 4 focus groups made up of 3 to 6 individuals. Each focus group consisted of individuals from a specific profession (e.g., surgeons, anesthesiologists, nurses, and surgical technicians). Questions were revised based on focus group recommendations, resulting in a final 52-question set. The question set was then distributed to MIS team members. Individuals were included if they had participated in >10 MIS cases and worked in the MIS setting in the past 3 months. Participants in the trial population were asked to repeat the questionnaire 4 weeks later to evaluate internal consistency. Participants' demographics, including age, gender, specialty, profession, and years of experience, were captured in the questionnaire. Factor analysis with varimax rotation was performed to determine domains (questions evaluating similar themes). For internal consistency and reliability, domains were tested using interitem correlations and Cronbach's α. Cronbach's α > .6 was considered internally consistent. Kendall's correlation coefficient τ closer to 1 and with p < .05 was considered significant for the test-retest reliability. Two hundred fifty participants answered the initial question set. Of those, 53 were eliminated because they did not meet inclusion criteria or failed to answer all questions, leaving 197 participants. Most participants were women (68% vs 32%), and 42% were between the ages 30 and 39 years. Factor analysis identified 6 domains: collaboration, error reporting, job proficiency/efficiency, problem-solving, job satisfaction, and situational awareness. Interitem correlations testing for redundancy for each domain ranged from .2 to .7, suggesting similar themed questions while avoiding redundancy. Cronbach's α, testing internal consistency, was .87. Sixty-two participants from the original cohort repeated the question set at 4 weeks. Forty-three were analyzed for test-retest reliability after excluding those who did not meet inclusion criteria. The final questions showed high test-retest reliability (τ = .3-.7, p < .05). The final questionnaire was made up of 29 questions from the original 52 question set. The MISS is a reliable and valid tool that can be used to measure how surgical team members conceptualize the requirements for successful MIS. The MISS revealed that participants identified 6 important domains of a successful workenvironment: collaboration, error reporting, job proficiency/efficiency, problem-solving, job satisfaction, and situational awareness. The questionnaire can be used to understand and align various surgical team members' goals and expectations and may help improve quality of care in the MIS setting. Copyright © 2017 American Association of Gynecologic Laparoscopists. Published by Elsevier Inc. All rights reserved.

The European DISABKIDS project: development of seven condition-specific modules to measure health related quality of life in children and adolescents

PubMed Central

Baars, Rolanda M; Atherton, Clare I; Koopman, Hendrik M; Bullinger, Monika; Power, Mick

2005-01-01

Background The European DISABKIDS project aims to enhance the Health Related Quality of Life (HRQoL) of children and adolescents with chronic medical conditions and their families. We describe the development of the seven cross-nationally tested condition-specific modules of the European DISABKIDS HRQoL instrument in a population of children and adolescents. The condition-specific modules are intended for use in conjunction with the DISABKIDS chronic generic module. Methods Focus groups were used to construct the pilot version of the DISABKIDS condition-specific HRQoL modules for asthma, juvenile idiopathic arthritis, atopic dermatitis, cerebral palsy, cystic fibrosis, diabetes and epilepsy. Analyses were conducted on pilot test data in order to construct field test versions of the modules. A series of factor analyses were run, first, to determine potential structures for each condition-specific module, and, secondly, to select a reduced number of items from the pilot test to be included in the field test. Post-field test analyses were conducted to retest the domain structure for the final DISABKIDS condition-specific modules. Results The DISABKIDS condition-specific modules were tested in a pilot study of 360 respondents, and subsequently in a field test of 1152 respondents in 7 European countries. The final condition-specific modules consist of an 'Impact' domain and an additional domain (e.g. worry, stigma, treatment) with between 10 to 12 items in total. The Cronbach's alpha of the final domains was found to vary from 0.71 to 0.90. Conclusion The condition-specific modules of the DISABKIDS instrument were developed through a step-by-step process including cognitive interview, clinical expertise, factor analysis, correlations and internal consistency. A cross-national pilot and field test were necessary to collect these data. In general, the internal consistency of the domains was satisfactory to high. In future, the DISABKIDS instrument may serve as a useful tool with which to assess HRQoL in children and adolescents with a chronic condition. The condition-specific modules can be used in conjunction with the DISABKIDS chronic generic module. PMID:16283947

The European DISABKIDS project: development of seven condition-specific modules to measure health related quality of life in children and adolescents.

PubMed

Baars, Rolanda M; Atherton, Clare I; Koopman, Hendrik M; Bullinger, Monika; Power, Mick

2005-11-13

The European DISABKIDS project aims to enhance the Health Related Quality of Life (HRQoL) of children and adolescents with chronic medical conditions and their families. We describe the development of the seven cross-nationally tested condition-specific modules of the European DISABKIDS HRQoL instrument in a population of children and adolescents. The condition-specific modules are intended for use in conjunction with the DISABKIDS chronic generic module. Focus groups were used to construct the pilot version of the DISABKIDS condition-specific HRQoL modules for asthma, juvenile idiopathic arthritis, atopic dermatitis, cerebral palsy, cystic fibrosis, diabetes and epilepsy. Analyses were conducted on pilot test data in order to construct field test versions of the modules. A series of factor analyses were run, first, to determine potential structures for each condition-specific module, and, secondly, to select a reduced number of items from the pilot test to be included in the field test. Post-field test analyses were conducted to retest the domain structure for the final DISABKIDS condition-specific modules. The DISABKIDS condition-specific modules were tested in a pilot study of 360 respondents, and subsequently in a field test of 1152 respondents in 7 European countries. The final condition-specific modules consist of an 'Impact' domain and an additional domain (e.g. worry, stigma, treatment) with between 10 to 12 items in total. The Cronbach's alpha of the final domains was found to vary from 0.71 to 0.90. The condition-specific modules of the DISABKIDS instrument were developed through a step-by-step process including cognitive interview, clinical expertise, factor analysis, correlations and internal consistency. A cross-national pilot and field test were necessary to collect these data. In general, the internal consistency of the domains was satisfactory to high. In future, the DISABKIDS instrument may serve as a useful tool with which to assess HRQoL in children and adolescents with a chronic condition. The condition-specific modules can be used in conjunction with the DISABKIDS chronic generic module.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Robb, Kevin R.; Jain, Prashant K.; Hazelwood, Thomas J.

Fluoride salt cooled high-temperature reactor (FHR) concepts include pumps for forced circulation of the primary and secondary coolants. As part of a cooperative research and development agreement between the Shanghai Institute of Applied Physics and the Oak Ridge National Laboratory (ORNL), a research project was initiated to aid in the development of pumps for high-temperature salts. The objectives of the task included characterization of the behavior of an existing ORNL LSTL pump; design and test a modified impeller and volute for improved pump characteristics; and finally, provide lessons learned, recommendations, and guidelines for salt pump development and design. The pumpmore » included on the liquid salt test loop (LSTL) at ORNL served as a case study. This report summarizes the progress to date. The report is organized as follows. First, there is a review, focused on pumps, of the significant amount of work on salts at ORNL during the 1950s 1970s. The existing pump on the LSTL is then described. Plans for hot and cold testing of the pump are then discussed, including the design for a cold shakedown test stand and the required LSTL modifications for hot testing. Initial hydraulic and vibration modeling of the LSTL pump is documented. Later, test data from the LSTL will be used to validate the modeling approaches, which could then be used for future pump design efforts. Some initial insights and test data from the pump are then provided. Finally, some preliminary design goals and requirements for a future LSTL pump are provided as examples of salt pump design considerations.« less

Final Report Feasibility Study for the California Wave Energy Test Center (CalWavesm) - Volume #2 - Appendices #16-17

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dooher, Brendan; Toman, William I.; Davy, Doug M.

The California Wave Energy Test Center (CalWave) Feasibility Study project was funded over multiple phases by the Department of Energy to perform an interdisciplinary feasibility assessment to analyze the engineering, permitting, and stakeholder requirements to establish an open water, fully energetic, grid connected, wave energy test center off the coast of California for the purposes of advancing U.S. wave energy research, development, and testing capabilities. Work under this grant included wave energy resource characterization, grid impact and interconnection requirements, port infrastructure and maritime industry capability/suitability to accommodate the industry at research, demonstration and commercial scale, and macro and micro sitingmore » considerations. CalWave Phase I performed a macro-siting and down-selection process focusing on two potential test sites in California: Humboldt Bay and Vandenberg Air Force Base. This work resulted in the Vandenberg Air Force Base site being chosen as the most favorable site based on a peer reviewed criteria matrix. CalWave Phase II focused on four siting location alternatives along the Vandenberg Air Force Base coastline and culminated with a final siting down-selection. Key outcomes from this work include completion of preliminary engineering and systems integration work, a robust turnkey cost estimate, shoreside and subsea hazards assessment, storm wave analysis, lessons learned reports from several maritime disciplines, test center benchmarking as compared to existing international test sites, analysis of existing applicable environmental literature, the completion of a preliminary regulatory, permitting and licensing roadmap, robust interaction and engagement with state and federal regulatory agency personnel and local stakeholders, and the population of a Draft Federal Energy Regulatory Commission (FERC) Preliminary Application Document (PAD). Analysis of existing offshore oil and gas infrastructure was also performed to assess the potential value and re-use scenarios of offshore platform infrastructure and associated subsea power cables and shoreside substations. The CalWave project team was well balanced and was comprised of experts from industry, academia, state and federal regulatory agencies. The result of the CalWave feasibility study finds that the CalWave Test Center has the potential to provide the most viable path to commercialization for wave energy in the United States.« less

2017-04-28_B61-12-Program Overview(OUO).

DOE Office of Scientific and Technical Information (OSTI.GOV)

Daniels, Vonceil

2017-04-01

The B61-12 LEP is currently executing Phase 6.4 Production Engineering with a focus on qualification and preproduction activities. All major milestones have been successfully completed to date. Component Final Design Reviews (FDRs) continue in FY17, with 19 of 38 complete as of April 28. A series of normal and abnormal environments tests occurred in the first half of FY17, and the first qualification flight test on an F-16 was executed in March. Two F-15 qualification flight tests are planned in August. To support Pantex readiness, the first all-up-round (AUR) trainer builds were completed in December 2016. Progress is ongoing towardmore » closure of Air Force Nuclear Weapons Center (tailkit) and Los Alamos National Laboratory interface gaps, and resolution of producibility challenges with the Kansas City National Security Campus (KCNSC).« less

Design, Development and Testing of Airplanes for Mars Exploration

NASA Technical Reports Server (NTRS)

Hall, David W.

2004-01-01

The opportunity for a piggyback mission to Mars aboard an Ariane 5 rocket in the early spring of 1999 set off feverish design activity at several NASA centers. This report describes the contract work done by faculty, students, and consultants at the California Polytechnic State University in San Luis Obispo California (Cal poly/SLO) to support the NASA/Ames design, construction and test efforts to develop a simple and robust Mars Flyer configuration capable of performing a practical science mission on Mars. The first sections will address the conceptual design of a workable Mars Flyer configuration which started in the spring and summer of 1999. The following sections will focus on construction and flight test of two full-scale vehicles. The final section will reflect on the overall effort and make recommendations for future work.

Turbulence and transition modeling for high-speed flows

NASA Technical Reports Server (NTRS)

Wilcox, David C.

1993-01-01

Research conducted during the past three and a half years aimed at developing and testing a turbulence/transition model applicable to high-speed turbulent flows is summarized. The first two years of the project focused on fully turbulent flows, while emphasis shifted to boundary-layer development in the transition region during the final year and a half. A brief summary of research accomplished during the first three years is included and publications that describe research results in greater detail are cited. Research conducted during the final six months of the period of performance is summarized. The primary results of the last six months of the project are elimination of the k-omega model's sensitivity to the freestream value of omega and development of a method for triggering transition at a specified location, independent of the freestream turbulence level.

Consensus report on the future of animal-free systemic toxicity testing.

PubMed

Leist, Marcel; Hasiwa, Nina; Rovida, Costanza; Daneshian, Mardas; Basketter, David; Kimber, Ian; Clewell, Harvey; Gocht, Tilman; Goldberg, Alan; Busquet, Francois; Rossi, Anna-Maria; Schwarz, Michael; Stephens, Martin; Taalman, Rob; Knudsen, Thomas B; McKim, James; Harris, Georgina; Pamies, David; Hartung, Thomas

2014-01-01

Since March 2013, animal use for cosmetics testing for the European market has been banned. This requires a renewed view on risk assessment in this field. However, in other fields as well, traditional animal experimentation does not always satisfy requirements in safety testing, as the need for human-relevant information is ever increasing. A general strategy for animal-free test approaches was outlined by the US National Research Council`s vision document for Toxicity Testing in the 21st Century in 2007. It is now possible to provide a more defined roadmap on how to implement this vision for the four principal areas of systemic toxicity evaluation: repeat dose organ toxicity, carcinogenicity, reproductive toxicity and allergy induction (skin sensitization), as well as for the evaluation of toxicant metabolism (toxicokinetics) (Fig. 1). CAAT-Europe assembled experts from Europe, America and Asia to design a scientific roadmap for future risk assessment approaches and the outcome was then further discussed and refined in two consensus meetings with over 200 stakeholders. The key recommendations include: focusing on improving existing methods rather than favoring de novo design; combining hazard testing with toxicokinetics predictions; developing integrated test strategies; incorporating new high content endpoints to classical assays; evolving test validation procedures; promoting collaboration and data-sharing of different industrial sectors; integrating new disciplines, such as systems biology and high throughput screening; and involving regulators early on in the test development process. A focus on data quality, combined with increased attention to the scientific background of a test method, will be important drivers. Information from each test system should be mapped along adverse outcome pathways. Finally, quantitative information on all factors and key events will be fed into systems biology models that allow a probabilistic risk assessment with flexible adaptation to exposure scenarios and individual risk factors.

Marine Animal Alert System -- Task 2.1.5.3: Development of Monitoring Technologies -- FY 2011 Progress Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carlson, Thomas J.; Deng, Zhiqun; Myers, Joshua R.

2011-09-30

The Marine Animal Alert System (MAAS) in development by the Pacific Northwest National Laboratory is focused on providing elements of compliance monitoring to support deployment of marine hydrokinetic energy devices. An initial focus is prototype tidal turbines to be deployed in Puget Sound in Washington State. The MAAS will help manage the risk of injury or mortality to marine animals from blade strike or contact with tidal turbines. In particular, development has focused on detection, classification, and localization of listed Southern Resident killer whales within 200 m of prototype turbines using both active and passive acoustic approaches. At the closemore » of FY 2011, a passive acoustic system consisting of a pair of four-element star arrays and parallel processing of eight channels of acoustic receptions has been designed and built. Field tests of the prototype system are scheduled for the fourth quarter of calendar year 2011. Field deployment and testing of the passive acoustic prototype is scheduled for the first quarter of FY 2012. The design of an active acoustic system that could be built using commercially available off-the-shelf components from active acoustic system vendors is also in the final stages of design and specification.« less

Evaluating #VetFinals: Can Twitter help students prepare for final examinations?

PubMed

Kinnison, Tierney; Whiting, Martin; Magnier, Kirsty; Mossop, Liz

2017-04-01

Twitter is increasingly used in education. In this article, Twitter was evaluated for its potential to aid veterinary students in their preparation for final examinations. "#VetFinals" revision sessions were facilitated by experts on a variety of topics. The initiative was evaluated through consideration of potential participants, session content and student experiences. In analysis of nine sessions, 52 students participated from eight veterinary schools. During a session, the facilitator tweeted 66 times on average, primarily asking a general question. Students on average tweeted 84 times, mostly in response to facilitators. They also asked novel questions and responded to fellow students. Focus groups and interviews with 11 students suggested that: sessions are useful for preparation/self-testing to succeed in exams; the facilitator and session style impact on learning; the sessions feel like personalized learning; there are elements of safety and exposure leading to some fear of tweeting; peer-learning promotes competition; a community of learners was formed; Twitter has become a part of normal professional life. Whilst not all students will take part in this type of social media use, many found it beneficial. The importance of the facilitator suggests the need for faculty development.

Final Technical Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Held, Isaac; V. Balaji; Fueglistaler, Stephan

We have constructed and analyzed a series of idealized models of tropical convection interacting with large-scale circulations, with 25-50km resolution and with 1-2km cloud resolving resolution to set the stage for rigorous tests of convection closure schemes in high resolution global climate models. Much of the focus has been on the climatology of tropical cyclogenesis in rotating systems and the related problem of the spontaneous aggregation of convection in non-rotating systems. The PI (Held) will be delivering the honorary Bjerknes lecture at the Fall 2016 AGU meeting in December on this work. We have also provided new analyses of long-standingmore » issues related to the interaction between convection and the large-scale circulation: Kelvin waves in the upper troposphere and lower stratosphere, water vapor transport into the stratosphere, and upper tropospheric temperature trends. The results of these analyses help to improve our understanding of processes, and provide tests for future high resolution global modeling. Our final goal of testing new convections schemes in next-generation global atmospheric models at GFDL has been left for future work due to the complexity of the idealized model results meant as tests for these models uncovered in this work and to computational resource limitations. 11 papers have been published with support from this grant, 2 are in review, and another major summary paper is in preparation.« less

Comparative Analyses of Zebrafish Anxiety-Like Behavior Using Conflict-Based Novelty Tests.

PubMed

Kysil, Elana V; Meshalkina, Darya A; Frick, Erin E; Echevarria, David J; Rosemberg, Denis B; Maximino, Caio; Lima, Monica Gomes; Abreu, Murilo S; Giacomini, Ana C; Barcellos, Leonardo J G; Song, Cai; Kalueff, Allan V

2017-06-01

Modeling of stress and anxiety in adult zebrafish (Danio rerio) is increasingly utilized in neuroscience research and central nervous system (CNS) drug discovery. Representing the most commonly used zebrafish anxiety models, the novel tank test (NTT) focuses on zebrafish diving in response to potentially threatening stimuli, whereas the light-dark test (LDT) is based on fish scototaxis (innate preference for dark vs. bright areas). Here, we systematically evaluate the utility of these two tests, combining meta-analyses of published literature with comparative in vivo behavioral and whole-body endocrine (cortisol) testing. Overall, the NTT and LDT behaviors demonstrate a generally good cross-test correlation in vivo, whereas meta-analyses of published literature show that both tests have similar sensitivity to zebrafish anxiety-like states. Finally, NTT evokes higher levels of cortisol, likely representing a more stressful procedure than LDT. Collectively, our study reappraises NTT and LDT for studying anxiety-like states in zebrafish, and emphasizes their developing utility for neurobehavioral research. These findings can help optimize drug screening procedures by choosing more appropriate models for testing anxiolytic or anxiogenic drugs.

MediCaring: development and test marketing of a supportive care benefit for older people.

PubMed

Lynn, J; O'Connor, M A; Dulac, J D; Roach, M J; Ross, C S; Wasson, J H

1999-09-01

To develop an alternative healthcare benefit (called MediCaring) and to assess the preferences of older Medicare beneficiaries concerning this benefit, which emphasizes more home-based and supportive health care and discourages use of hospitalization and aggressive treatment. To evaluate the beneficiaries' ability to understand and make a choice regarding health insurance benefits; to measure their likelihood to change from traditional Medicare to the new MediCaring benefit; and to determine the short-term stability of that choice. Focus groups of persons aged 65+ and family members shaped the potential MediCaring benefit. A panel of 50 national experts critiqued three iterations of the benefit. The final version was test marketed by discussing it with 382 older people (men > or = 75 years and women > or = 80 years) in their homes. Telephone surveys a few days later, and again 1 month after the home interview, assessed the potential beneficiaries' understanding and preferences concerning MediCaring and the stability of their responses. Focus groups were held in community settings in New Hampshire, Washington, DC, Cleveland, OH, and Columbia, SC. Test marketing occurred in New Hampshire, Cleveland, OH; Columbia, SC, and Los Angeles, CA. Focus group participants were persons more than 65 years old (11 focus groups), healthcare providers (9 focus groups), and family decision-makers (3 focus groups). Participants in the in-home informing (test marketing group) were persons older than 75 years who were identified through contact with a variety of services. Demographics, health characteristics, understanding, and preferences. Focus group beneficiaries between the ages of 65 and 74 generally wanted access to all possible medical treatment and saw MediCaring as a need of persons older than themselves. Those older than age 80 were mostly in favor of it. Test marketing participants understood the key points of the new benefit: 74% generally liked it, and 34% said they would take it now. Preferences were generally stable at 1 month. In multivariate regression, those preferring MediCaring were wealthier, more often white, more often living in senior housing, and using more homecare services. However, they were not more often in poor health or needing ADL assistance. Older persons aged more than 80 years can understand a health benefit choice; most liked the aims of a new supportive care benefit, and 34% would change immediately from Medicare to a supportive care benefit such as MediCaring,. These findings encourage further development of special programs of care, such as MediCaring, that prioritize comfort and support for the old old.

An Integrated Approach to Exploration Launch Office Requirements Development

NASA Technical Reports Server (NTRS)

Holladay, Jon B.; Langford, Gary

2006-01-01

The proposed paper will focus on the Project Management and Systems Engineering approach utilized to develop a set of both integrated and cohesive requirements for the Exploration Launch Office, within the Constellation Program. A summary of the programmatic drivers which influenced the approach along with details of the resulting implementation will be discussed as well as metrics evaluating the efficiency and accuracy of the various requirements development activities. Requirements development activities will focus on the procedures utilized to ensure that technical content was valid and mature in preparation for the Crew Launch Vehicle and Constellation System s Requirements Reviews. This discussion will begin at initial requirements development during the Exploration Systems Architecture Study and progress through formal development of the program structure. Specific emphasis will be given to development and validation of the requirements. This discussion will focus on approaches to garner the appropriate requirement owners (or customers), project infrastructure utilized to emphasize proper integration, and finally the procedure to technically mature, verify and validate the requirements. Examples of requirements being implemented on the Launch Vehicle (systems, interfaces, test & verification) will be utilized to demonstrate the various processes and also provide a top level understanding of the launch vehicle(s) performance goals. Details may also be provided on the approaches for verification, which range from typical aerospace hardware development (qualification/acceptance) through flight certification (flight test, etc.). The primary intent of this paper is to provide a demonstrated procedure for the development of a mature, effective, integrated set of requirements on a complex system, which also has the added intricacies of both heritage and new hardware development integration. Ancillary focus of the paper will include discussion of Test and Verification approaches along with top level systems/elements performance capabilities.

Shape Control of Solar Collectors Using Shape Memory Alloy Actuators

NASA Technical Reports Server (NTRS)

Lobitz, D. W.; Grossman, J. W.; Allen, J. J.; Rice, T. M.; Liang, C.; Davidson, F. M.

1996-01-01

Solar collectors that are focused on a central receiver are designed with a mechanism for defocusing the collector or disabling it by turning it out of the path of the sun's rays. This is required to avoid damaging the receiver during periods of inoperability. In either of these two cases a fail-safe operation is very desirable where during power outages the collector passively goes to its defocused or deactivated state. This paper is principally concerned with focusing and defocusing the collector in a fail-safe manner using shape memory alloy actuators. Shape memory alloys are well suited to this application in that once calibrated the actuators can be operated in an on/off mode using a minimal amount of electric power. Also, in contrast to other smart materials that were investigated for this application, shape memory alloys are capable of providing enough stroke at the appropriate force levels to focus the collector. Design and analysis details presented, along with comparisons to test data taken from an actual prototype, demonstrate that the collector can be repeatedly focused and defocused within accuracies required by typical solar energy systems. In this paper the design, analysis and testing of a solar collector which is deformed into its desired shape by shape memory alloy actuators is presented. Computations indicate collector shapes much closer to spherical and with smaller focal lengths can be achieved by moving the actuators inward to a radius of approximately 6 inches. This would require actuators with considerably more stroke and some alternate SMA actuators are currently under consideration. Whatever SMA actuator is finally chosen for this application, repeatability and fatigue tests will be required to investigate the long term performance of the actuator.

Language proficiency and nursing registration.

PubMed

Müller, Amanda

2016-02-01

This discussion paper focuses on English proficiency standards for nursing registration in Australia, how Australia has dealt with the issue of language proficiency, and the factors which have led to the establishment of the current language standards. Also, this paper will provide a comparison of the two language tests that are currently accepted in Australia (OET and IELTS), including the appropriateness of these tests and the minimum standards used. The paper will also examine the use of educational background as an indicator of language proficiency. Finally, communication-based complaints in the post-registration environment will be explored, and some discussion will be provided about why pre-registration measures might have failed to prevent such problematic situations from occurring. Copyright © 2015 Elsevier Ltd. All rights reserved.

Advanced expander test bed program

NASA Technical Reports Server (NTRS)

Riccardi, D. P.; Mitchell, J. C.

1993-01-01

The Advanced Expander Test Bed (AETB) is a key element in NASA's Space Chemical Engine Technology Program for development and demonstration of expander cycle oxygen/hydrogen engine and advanced component technologies applicable to space engines as well as launch vehicle upper stage engines. The AETB will be used to validate the high-pressure expander cycle concept, investigate system interactions, and conduct investigations of advanced mission focused components and new health monitoring techniques in an engine system environment. The split expander cycle AETB will operate at combustion chamber pressures up to 1200 psia with propellant flow rates equivalent to 20,000 lbf vacuum thrust. Contract work began 27 Apr. 1990. During 1992, a major milestone was achieved with the review of the final design of the oxidizer turbopump in Sep. 1992.

Reliability evaluation of microgrid considering incentive-based demand response

NASA Astrophysics Data System (ADS)

Huang, Ting-Cheng; Zhang, Yong-Jun

2017-07-01

Incentive-based demand response (IBDR) can guide customers to adjust their behaviour of electricity and curtail load actively. Meanwhile, distributed generation (DG) and energy storage system (ESS) can provide time for the implementation of IBDR. The paper focus on the reliability evaluation of microgrid considering IBDR. Firstly, the mechanism of IBDR and its impact on power supply reliability are analysed. Secondly, the IBDR dispatch model considering customer’s comprehensive assessment and the customer response model are developed. Thirdly, the reliability evaluation method considering IBDR based on Monte Carlo simulation is proposed. Finally, the validity of the above models and method is studied through numerical tests on modified RBTS Bus6 test system. Simulation results demonstrated that IBDR can improve the reliability of microgrid.

[Prospect of the Advanced Life Support Program Breadboard Project at Kennedy Space Center in USA].

PubMed

Guo, S S; Ai, W D

2001-04-01

The Breadboard Project at Kennedy Space Center in NASA of USA was focused on the development of the bioregenerative life support components, crop plants for water, air, and food production and bioreactors for recycling of wastes. The keystone of the Breadboard Project was the Biomass Production Chamber (BPC), which was supported by 15 environmentally controlled chambers and several laboratory facilities holding a total area of 2150 m2. In supporting the Advanced Life Support Program (ALS Program), the Project utilizes these facilities for large-scale testing of components and development of required technologies for human-rated test-beds at Johnson Space Center in NASA, in order to enable a Lunar and a Mars mission finally.

Simulation and ground testing with the Advanced Video Guidance Sensor

NASA Technical Reports Server (NTRS)

Howard, Richard T.; Johnston, Albert S.; Bryan, Thomas C.; Book, Michael L.

2005-01-01

The Advanced Video Guidance Sensor (AVGS), an active sensor system that provides near-range 6-degree-of-freedom sensor data, has been developed as part of an automatic rendezvous and docking system for the Demonstration of Autonomous Rendezvous Technology (DART). The sensor determines the relative positions and attitudes between the active sensor and the passive target at ranges up to 300 meters. The AVGS uses laser diodes to illuminate retro-reflectors in the target, a solid-state imager to detect the light returned from the target, and image capture electronics and a digital signal processor to convert the video information into the relative positions and attitudes. The development of the sensor, through initial prototypes, final prototypes, and three flight units, has required a great deal of testing at every phase, and the different types of testing, their effectiveness, and their results, are presented in this paper, focusing on the testing of the flight units. Testing has improved the sensor's performance.

A Lift-Off-Tolerant Magnetic Flux Leakage Testing Method for Drill Pipes at Wellhead.

PubMed

Wu, Jianbo; Fang, Hui; Li, Long; Wang, Jie; Huang, Xiaoming; Kang, Yihua; Sun, Yanhua; Tang, Chaoqing

2017-01-21

To meet the great needs for MFL (magnetic flux leakage) inspection of drill pipes at wellheads, a lift-off-tolerant MFL testing method is proposed and investigated in this paper. Firstly, a Helmholtz coil magnetization method and the whole MFL testing scheme are proposed. Then, based on the magnetic field focusing effect of ferrite cores, a lift-off-tolerant MFL sensor is developed and tested. It shows high sensitivity at a lift-off distance of 5.0 mm. Further, the follow-up high repeatability MFL probing system is designed and manufactured, which was embedded with the developed sensors. It can track the swing movement of drill pipes and allow the pipe ends to pass smoothly. Finally, the developed system is employed in a drilling field for drill pipe inspection. Test results show that the proposed method can fulfill the requirements for drill pipe inspection at wellheads, which is of great importance in drill pipe safety.

A Lift-Off-Tolerant Magnetic Flux Leakage Testing Method for Drill Pipes at Wellhead

PubMed Central

Wu, Jianbo; Fang, Hui; Li, Long; Wang, Jie; Huang, Xiaoming; Kang, Yihua; Sun, Yanhua; Tang, Chaoqing

2017-01-01

To meet the great needs for MFL (magnetic flux leakage) inspection of drill pipes at wellheads, a lift-off-tolerant MFL testing method is proposed and investigated in this paper. Firstly, a Helmholtz coil magnetization method and the whole MFL testing scheme are proposed. Then, based on the magnetic field focusing effect of ferrite cores, a lift-off-tolerant MFL sensor is developed and tested. It shows high sensitivity at a lift-off distance of 5.0 mm. Further, the follow-up high repeatability MFL probing system is designed and manufactured, which was embedded with the developed sensors. It can track the swing movement of drill pipes and allow the pipe ends to pass smoothly. Finally, the developed system is employed in a drilling field for drill pipe inspection. Test results show that the proposed method can fulfill the requirements for drill pipe inspection at wellheads, which is of great importance in drill pipe safety. PMID:28117721

t4 Workshop Report

PubMed Central

Silbergeld, Ellen K.; Contreras, Elizabeth Q.; Hartung, Thomas; Hirsch, Cordula; Hogberg, Helena; Jachak, Ashish C.; Jordan, William; Landsiedel, Robert; Morris, Jeffery; Patri, Anil; Pounds, Joel G.; de Vizcaya Ruiz, Andrea; Shvedova, Anna; Tanguay, Robert; Tatarazako, Norihasa; van Vliet, Erwin; Walker, Nigel J.; Wiesner, Mark; Wilcox, Neil; Zurlo, Joanne

2014-01-01

Summary In October 2010, a group of experts met as part of the transatlantic think tank for toxicology (t4) to exchange ideas about the current status and future of safety testing of nanomaterials. At present, there is no widely accepted path forward to assure appropriate and effective hazard identification for engineered nanomaterials. The group discussed needs for characterization of nanomaterials and identified testing protocols that incorporate the use of innovative alternative whole models such as zebrafish or C. elegans, as well as in vitro or alternative methods to examine specific functional pathways and modes of action. The group proposed elements of a potential testing scheme for nanomaterials that works towards an integrated testing strategy, incorporating the goals of the NRC report Toxicity Testing in the 21st Century: A Vision and a Strategy by focusing on pathways of toxic response, and utilizing an evidence-based strategy for developing the knowledge base for safety assessment. Finally, the group recommended that a reliable, open, curated database be developed that interfaces with existing databases to enable sharing of information. PMID:21993959

Memory functions in chronic pain: examining contributions of attention and age to test performance.

PubMed

Oosterman, Joukje M; Derksen, Laura C; van Wijck, Albert J M; Veldhuijzen, Dieuwke S; Kessels, Roy P C

2011-01-01

Previous studies have revealed that memory performance is diminished in chronic pain patients. Few studies, however, have assessed multiple components of memory in a single sample. It is currently also unknown whether attentional problems, which are commonly observed in chronic pain, mediate the decline in memory. Finally, previous studies have focused on middle-aged adults, and a possible detrimental effect of aging on memory performance in chronic pain patients has been commonly disregarded. This study, therefore, aimed at describing the pattern of semantic, working, and visual and verbal episodic memory performance in participants with chronic pain, while testing for possible contributions of attention and age to task performance. Thirty-four participants with chronic pain and 32 pain-free participants completed tests of episodic, semantic, and working memory to assess memory performance and a test of attention. Participants with chronic pain performed worse on tests of working memory and verbal episodic memory. A decline in attention explained some, but not all, group differences in memory performance. Finally, no additional effect of age on the diminished task performance in participants with chronic pain was observed. Taken together, the results indicate that chronic pain significantly affects memory performance. Part of this effect may be caused by underlying attentional dysfunction, although this could not fully explain the observed memory decline. An increase in age in combination with the presence of chronic pain did not additionally affect memory performance.

Improving the Efficiency and Quality of the Value Assessment Process for Companion Diagnostic Tests: The Companion test Assessment Tool (CAT).

PubMed

Canestaro, William J; Pritchard, Daryl E; Garrison, Louis P; Dubois, Robert; Veenstra, David L

2015-08-01

Companion diagnostic tests (CDTs) have emerged as a vital technology in the effective use of an increasing number of targeted drug therapies. Although CDTs can offer a multitude of potential benefits, assessing their value within a health technology appraisal process can be challenging because of a complex array of factors that influence clinical and economic outcomes. To develop a user-friendly tool to assist managed care and other health care decision makers in screening companion tests and determining whether an intensive technology review is necessary and, if so, where the review should be focused to improve efficiency. First, we conducted a systematic literature review of CDT cost-effectiveness studies to identify value drivers. Second, we conducted key informant interviews with a diverse group of stakeholders to elicit feedback and solicit any additional value drivers and identify desirable attributes for an evidence review tool. A draft tool was developed based on this information that captured value drivers, usability features, and had a particular focus on practical use by nonexperts. Finally, the tool was pilot tested with test developers and managed care evidence evaluators to assess face-validity and usability. The tool was also evaluated using several diverse examples of existing companion diagnostics and refined accordingly. We identified 65 cost-effectiveness studies of companion diagnostic technologies. The following factors were most commonly identified as value drivers from our literature review: clinical validity of testing; efficacy, safety, and cost of baseline and alternative treatments; cost and mortality of health states; and biomarker prevalence and testing cost. Stakeholders identified the following additional factors that they believed influenced the overall value of a companion test: regulatory status, actionability, utility, and market penetration. These factors were used to maximize the efficiency of the evidence review process. Stakeholders also stated that a tool should be easy to use and time efficient. Cognitive interviews with stakeholders led to minor changes in the draft tool to improve usability and relevance. The final tool consisted of 4 sections: (1) eligibility for review (2 questions), (2) prioritization of review (3 questions), (3) clinical review (3 questions), and (4) economic review (5 questions). Although the evaluation of CDTs can be challenging because of limited evidence and the added complexity of incorporating a diagnostic test into drug treatment decisions, using a pragmatic tool to identify tests that do not need extensive evaluation may improve the efficiency and effectiveness of CDT value assessments.

Verbal Final Exam in Introductory Biology Yields Gains in Student Content Knowledge and Longitudinal Performance

PubMed Central

Luckie, Douglas B.; Rivkin, Aaron M.; Aubry, Jacob R.; Marengo, Benjamin J.; Creech, Leah R.; Sweeder, Ryan D.

2013-01-01

We studied gains in student learning over eight semesters in which an introductory biology course curriculum was changed to include optional verbal final exams (VFs). Students could opt to demonstrate their mastery of course material via structured oral exams with the professor. In a quantitative assessment of cell biology content knowledge, students who passed the VF outscored their peers on the medical assessment test (MAT), an exam built with 40 Medical College Admissions Test (MCAT) questions (66.4% [n = 160] and 62% [n = 285], respectively; p < 0.001);. The higher-achieving students performed better on MCAT questions in all topic categories tested; the greatest gain occurred on the topic of cellular respiration. Because the VF focused on a conceptually parallel topic, photosynthesis, there may have been authentic knowledge transfer. In longitudinal tracking studies, passing the VF also correlated with higher performance in a range of upper-level science courses, with greatest significance in physiology, biochemistry, and organic chemistry. Participation had a wide range but not equal representation in academic standing, gender, and ethnicity. Yet students nearly unanimously (92%) valued the option. Our findings suggest oral exams at the introductory level may allow instructors to assess and aid students striving to achieve higher-level learning. PMID:24006399

Melodic interval perception by normal-hearing listeners and cochlear implant users

PubMed Central

Luo, Xin; Masterson, Megan E.; Wu, Ching-Chih

2014-01-01

The perception of melodic intervals (sequential pitch differences) is essential to music perception. This study tested melodic interval perception in normal-hearing (NH) listeners and cochlear implant (CI) users. Melodic interval ranking was tested using an adaptive procedure. CI users had slightly higher interval ranking thresholds than NH listeners. Both groups' interval ranking thresholds, although not affected by root note, significantly increased with standard interval size and were higher for descending intervals than for ascending intervals. The pitch direction effect may be due to a procedural artifact or a difference in central processing. In another test, familiar melodies were played with all the intervals scaled by a single factor. Subjects rated how in tune the melodies were and adjusted the scaling factor until the melodies sounded the most in tune. CI users had lower final interval ratings and less change in interval rating as a function of scaling factor than NH listeners. For CI users, the root-mean-square error of the final scaling factors and the width of the interval rating function were significantly correlated with the average ranking threshold for ascending rather than descending intervals, suggesting that CI users may have focused on ascending intervals when rating and adjusting the melodies. PMID:25324084

Verbal final exam in introductory biology yields gains in student content knowledge and longitudinal performance.

PubMed

Luckie, Douglas B; Rivkin, Aaron M; Aubry, Jacob R; Marengo, Benjamin J; Creech, Leah R; Sweeder, Ryan D

2013-01-01

We studied gains in student learning over eight semesters in which an introductory biology course curriculum was changed to include optional verbal final exams (VFs). Students could opt to demonstrate their mastery of course material via structured oral exams with the professor. In a quantitative assessment of cell biology content knowledge, students who passed the VF outscored their peers on the medical assessment test (MAT), an exam built with 40 Medical College Admissions Test (MCAT) questions (66.4% [n = 160] and 62% [n = 285], respectively; p < 0.001);. The higher-achieving students performed better on MCAT questions in all topic categories tested; the greatest gain occurred on the topic of cellular respiration. Because the VF focused on a conceptually parallel topic, photosynthesis, there may have been authentic knowledge transfer. In longitudinal tracking studies, passing the VF also correlated with higher performance in a range of upper-level science courses, with greatest significance in physiology, biochemistry, and organic chemistry. Participation had a wide range but not equal representation in academic standing, gender, and ethnicity. Yet students nearly unanimously (92%) valued the option. Our findings suggest oral exams at the introductory level may allow instructors to assess and aid students striving to achieve higher-level learning.

The Induction of Chaos in Electronic Circuits Final Report-October 1, 2001

DOE Office of Scientific and Technical Information (OSTI.GOV)

R.M.Wheat, Jr.

2003-04-01

This project, now known by the name ''Chaos in Electronic Circuits,'' was originally tasked as a two-year project to examine various ''fault'' or ''non-normal'' operational states of common electronic circuits with some focus on determining the feasibility of exploiting these states. Efforts over the two-year duration of this project have been dominated by the study of the chaotic behavior of electronic circuits. These efforts have included setting up laboratory space and hardware for conducting laboratory tests and experiments, acquiring and developing computer simulation and analysis capabilities, conducting literature surveys, developing test circuitry and computer models to exercise and test ourmore » capabilities, and experimenting with and studying the use of RF injection as a means of inducing chaotic behavior in electronics. An extensive array of nonlinear time series analysis tools have been developed and integrated into a package named ''After Acquisition'' (AA), including capabilities such as Delayed Coordinate Embedding Mapping (DCEM), Time Resolved (3-D) Fourier Transform, and several other phase space re-creation methods. Many computer models have been developed for Spice and for the ATP (Alternative Transients Program), modeling the several working circuits that have been developed for use in the laboratory. And finally, methods of induction of chaos in electronic circuits have been explored.« less

Establishing the content validity of the Sexual Arousal, Interest, and Drive Scale and the Hypogonadism Energy Diary.

PubMed

Hayes, R P; Henne, J; Kinchen, K S

2015-04-01

The aim of this qualitative analysis was to establish the content validity of two new patient-reported outcome (PRO) measures: Sexual Arousal, Interest, and Drive Scale (SAID) and Hypogonadism Energy Diary (HED). Four separate qualitative studies were conducted with 125 men with hypogonadism (mean age: 53 years, 85% adult onset). Study 1 used focus groups/interviews to identify important and relevant concepts related to the experience of hypogonadism and its treatment in men primarily with adult-onset hypogonadism. Study 2 tested items generated for assessments of low sex drive and low energy. Study 3 used interviews to confirm in men with early-onset hypogonadism that low sex drive and low energy were also important and relevant symptoms. Study 4 tested final versions of the two PROs and determined equivalency of paper-based and electronic versions of the two PROs. Of the concepts emerging in Studies 1 and 3, low sex drive and low energy were the symptoms most often spontaneously mentioned. Coding of transcripts from Studies 1 and 3 led to the generation of items for the SAID and HED. After item testing (Studies 2 and 4), the final SAID included five items pertaining to arousal, interest in sex and sex drive with a 7-day recall period and the final HED included two items (energy, tired/exhausted) to be administered three times per day. The SAID and HED have content validity established according to regulatory guidance and, therefore, the potential to provide the patient perspective of treatments for hypogonadism. © 2014 John Wiley & Sons Ltd.

The new design of final optics assembly on SG-III prototype facility

NASA Astrophysics Data System (ADS)

Li, Ping; Zhao, Runchang; Wang, Wei; Jia, Huaiting; Chen, Liangmin; Su, Jingqin

2014-09-01

To improve the performance of SG-III prototype facility (TIL-Technical Integration Line), final optics assembly (FOA) is re-designed. It contains that stray light and focusing ghosts are optimized, operational performance and environments are improved and the total thickness of optics is reduced. With the re-designed FOA, Some performance advantages are achieved. First, the optics damages are mitigated obviously, especially crystals and Focus lens; Second, stray light and focusing ghosts are controlled better that organic contamination sources inside FOA are eliminated; Third, maintenance and operation are more convenient for the atoms environment; Fourth, the focusable power on target is increased for lower B-integral.

Development of a measure of asthma-specific quality of life among adults.

PubMed

Eberhart, Nicole K; Sherbourne, Cathy D; Edelen, Maria Orlando; Stucky, Brian D; Sin, Nancy L; Lara, Marielena

2014-04-01

A key goal in asthma treatment is improvement in quality of life (QoL), but existing measures often confound QoL with symptoms and functional impairment. The current study addresses these limitations and the need for valid patient-reported outcome measures by using state-of-the-art methods to develop an item bank assessing QoL in adults with asthma. This article describes the process for developing an initial item pool for field testing. Five focus group interviews were conducted with a total of 50 asthmatic adults. We used "pile sorting/binning" and "winnowing" methods to identify key QoL dimensions and develop a pool of items based on statements made in the focus group interviews. We then conducted a literature review and consulted with an expert panel to ensure that no key concepts were omitted. Finally, we conducted individual cognitive interviews to ensure that items were well understood and inform final item refinement. Six hundred and sixty-one QoL statements were identified from focus group interview transcripts and subsequently used to generate a pool of 112 items in 16 different content areas. Items covering a broad range of content were developed that can serve as a valid gauge of individuals' perceptions of the effects of asthma and its treatment on their lives. These items do not directly measure symptoms or functional impairment, yet they include a broader range of content than most existent measures of asthma-specific QoL.

Development of a Measure of Asthma-Specific Quality of Life among Adults

PubMed Central

Eberhart, Nicole K.; Sherbourne, Cathy D.; Edelen, Maria Orlando; Stucky, Brian D.; Sin, Nancy L.; Lara, Marielena

2014-01-01

Purpose A key goal in asthma treatment is improvement in quality of life (QoL), but existing measures often confound QoL with symptoms and functional impairment. The current study addresses these limitations and the need for valid patient-reported outcome measures by using state-of-the-art methods to develop an item bank assessing QoL in adults with asthma. This article describes the process for developing an initial item pool for field testing. Methods Five focus group interviews were conducted with a total of 50 asthmatic adults. We used “pile sorting/binning” and “winnowing” methods to identify key QoL dimensions and develop a pool of items based on statements made in the focus group interviews. We then conducted a literature review and consulted with an expert panel to ensure that no key concepts were omitted. Finally, we conducted individual cognitive interviews to ensure that items were well understood and inform final item refinement. Results 661 QoL statements were identified from focus group interview transcripts and subsequently used to generate a pool of 112 items in 16 different content areas. Conclusions Items covering a broad range of content were developed that can serve as a valid gauge of individuals’ perceptions of the effects of asthma and its treatment on their lives. These items do not directly measure symptoms or functional impairment, yet they include a broader range of content than most existent measures of asthma-specific QoL. PMID:24062237

James Webb Space Telescope: Frequently Asked Questions for Scientists and Engineers

NASA Technical Reports Server (NTRS)

Gardner, Jonathan P.

2008-01-01

JWST will be tested incrementally during its construction, starting with individual mirrors and instruments (including cameras and spectrometers) and building up to the full observatory. JWST's mirrors and the telescope structure are first each tested individually, including optical testing of the mirrors and alignment testing of the structure inside a cold thermal-vacuum chamber. The mirrors are then installed on the telescope structure in a clean room at Goddard Space Flight Center (GSFC). In parallel to the telescope assembly and alignment, the instruments are being built and tested, again first individually, and then as part of an integrated instrument assembly. The integrated instrument assembly will be tested in a thermal-vacuum chamber at GSFC using an optical simulator of the telescope. This testing makes sure the instruments are properly aligned relative to each other and also provides an independent check of the individual tests. After both the telescope and the integrated instrument module are successfully assembled, the integrated instrument module will be installed onto the telescope, and the combined system will be sent to Johnson Space Flight Center (JSC) where it will be optically tested in one of the JSC chambers. The process includes testing the 18 primary mirror segments acting as a single primary mirror, and testing the end-to-end system. The final system test will assure that the combined telescope and instruments are focused and aligned properly, and that the alignment, once in space, will be within the range of the actively controlled optics. In general, the individual optical tests of instruments and mirrors are the most accurate. The final system tests provide a cost-effective check that no major problem has occurred during assembly. In addition, independent optical checks of earlier tests will be made as the full system is assembled, providing confidence that there are no major problems.

Reduced-gravity environment hardware demonstrations of a prototype miniaturized flow cytometer and companion microfluidic mixing technology.

PubMed

Phipps, William S; Yin, Zhizhong; Bae, Candice; Sharpe, Julia Z; Bishara, Andrew M; Nelson, Emily S; Weaver, Aaron S; Brown, Daniel; McKay, Terri L; Griffin, DeVon; Chan, Eugene Y

2014-11-13

Until recently, astronaut blood samples were collected in-flight, transported to earth on the Space Shuttle, and analyzed in terrestrial laboratories. If humans are to travel beyond low Earth orbit, a transition towards space-ready, point-of-care (POC) testing is required. Such testing needs to be comprehensive, easy to perform in a reduced-gravity environment, and unaffected by the stresses of launch and spaceflight. Countless POC devices have been developed to mimic laboratory scale counterparts, but most have narrow applications and few have demonstrable use in an in-flight, reduced-gravity environment. In fact, demonstrations of biomedical diagnostics in reduced gravity are limited altogether, making component choice and certain logistical challenges difficult to approach when seeking to test new technology. To help fill the void, we are presenting a modular method for the construction and operation of a prototype blood diagnostic device and its associated parabolic flight test rig that meet the standards for flight-testing onboard a parabolic flight, reduced-gravity aircraft. The method first focuses on rig assembly for in-flight, reduced-gravity testing of a flow cytometer and a companion microfluidic mixing chip. Components are adaptable to other designs and some custom components, such as a microvolume sample loader and the micromixer may be of particular interest. The method then shifts focus to flight preparation, by offering guidelines and suggestions to prepare for a successful flight test with regard to user training, development of a standard operating procedure (SOP), and other issues. Finally, in-flight experimental procedures specific to our demonstrations are described.

Reduced-gravity Environment Hardware Demonstrations of a Prototype Miniaturized Flow Cytometer and Companion Microfluidic Mixing Technology

PubMed Central

Bae, Candice; Sharpe, Julia Z.; Bishara, Andrew M.; Nelson, Emily S.; Weaver, Aaron S.; Brown, Daniel; McKay, Terri L.; Griffin, DeVon; Chan, Eugene Y.

2014-01-01

Until recently, astronaut blood samples were collected in-flight, transported to earth on the Space Shuttle, and analyzed in terrestrial laboratories. If humans are to travel beyond low Earth orbit, a transition towards space-ready, point-of-care (POC) testing is required. Such testing needs to be comprehensive, easy to perform in a reduced-gravity environment, and unaffected by the stresses of launch and spaceflight. Countless POC devices have been developed to mimic laboratory scale counterparts, but most have narrow applications and few have demonstrable use in an in-flight, reduced-gravity environment. In fact, demonstrations of biomedical diagnostics in reduced gravity are limited altogether, making component choice and certain logistical challenges difficult to approach when seeking to test new technology. To help fill the void, we are presenting a modular method for the construction and operation of a prototype blood diagnostic device and its associated parabolic flight test rig that meet the standards for flight-testing onboard a parabolic flight, reduced-gravity aircraft. The method first focuses on rig assembly for in-flight, reduced-gravity testing of a flow cytometer and a companion microfluidic mixing chip. Components are adaptable to other designs and some custom components, such as a microvolume sample loader and the micromixer may be of particular interest. The method then shifts focus to flight preparation, by offering guidelines and suggestions to prepare for a successful flight test with regard to user training, development of a standard operating procedure (SOP), and other issues. Finally, in-flight experimental procedures specific to our demonstrations are described. PMID:25490614

Focusing Intense Charged Particle Beams with Achromatic Effects for Heavy Ion Fusion

NASA Astrophysics Data System (ADS)

Mitrani, James; Kaganovich, Igor

2012-10-01

Final focusing systems designed to minimize the effects of chromatic aberrations in the Neutralized Drift Compression Experiment (NDCX-II) are described. NDCX-II is a linear induction accelerator, designed to accelerate short bunches at high current. Previous experiments showed that neutralized drift compression significantly compresses the beam longitudinally (˜60x) in the z-direction, resulting in a narrow distribution in z-space, but a wide distribution in pz-space. Using simple lenses (e.g., solenoids, quadrupoles) to focus beam bunches with wide distributions in pz-space results in chromatic aberrations, leading to lower beam intensities (J/cm^2). Therefore, the final focusing system must be designed to compensate for chromatic aberrations. The paraxial ray equations and beam envelope equations are numerically solved for parameters appropriate to NDCX-II. Based on these results, conceptual designs for final focusing systems using a combination of solenoids and/or quadrupoles are optimized to compensate for chromatic aberrations. Lens aberrations and emittance growth will be investigated, and analytical results will be compared with results from numerical particle-in-cell (PIC) simulation codes.

Building from a conceptual model of the resilience process during ageing, towards the Groningen Aging Resilience Inventory.

PubMed

van Abbema, Renske; Bielderman, Annemiek; De Greef, Mathieu; Hobbelen, Hans; Krijnen, Wim; van der Schans, Cees

2015-09-01

To develop and psychometrically test the Groningen Ageing Resilience Inventory. Ageing is a process that is often accompanied by functional limitation, disabilities and losses. Instead of focusing on these negative events of ageing, there are opportunities in focusing on adaptation mechanisms, like resilience, that are helpful to cope with those adversities. Cross-sectional study. The study was conducted from 2011-2012. First, a conceptual model of resilience during the ageing process was constructed. Next, items were formulated that made up a comprehensive template questionnaire reflecting the model. Finally, a cross-sectional study was performed to evaluate the construct validity and internal consistency of this template 16-item questionnaire. Participants (N = 229) with a mean age of 71·5 years, completed the template 16-item Groningen Ageing Resilience Inventory, and performance based tests and psychological questionnaires. Exploratory factor analysis resulted in a two factor solution of internal and external resources of resilience. Three items did not discriminate well between the two factors and were deleted, remaining a final 13-item questionnaire that shows evidence of good internal consistency. The direction and magnitude of the correlations with other measures support the construct validity. The Groningen Ageing Resilience Inventory is a useful instrument that can help nurses, other healthcare workers, researchers and providers of informal care to identify the internal and external resources of resilience in individuals and groups. In a multidisciplinary biopsychosocial approach this knowledge provides tools for empowering older patients in performing health promoting behaviors and self-care tasks. © 2015 John Wiley & Sons Ltd.

Stirling Space Engine Program. Volume 1; Final Report

NASA Technical Reports Server (NTRS)

Dhar, Manmohan

1999-01-01

The objective of this program was to develop the technology necessary for operating Stirling power converters in a space environment and to demonstrate this technology in full-scale engine tests. Hardware development focused on the Component Test Power Converter (CTPC), a single cylinder, 12.5-kWe engine. Design parameters for the CTPC were 150 bar operating pressure, 70 Hz frequency, and hot-and cold-end temperatures of 1050 K and 525 K, respectively. The CTPC was also designed for integration with an annular sodium heat pipe at the hot end, which incorporated a unique "Starfish" heater head that eliminated highly stressed brazed or weld joints exposed to liquid metal and used a shaped-tubed electrochemical milling process to achieve precise positional tolerances. Selection of materials that could withstand high operating temperatures with long life were another focus. Significant progress was made in the heater head (Udimet 700 and Inconel 718 and a sodium-filled heat pipe); the alternator (polyimide-coated wire with polyimide adhesive between turns and a polyimide-impregnated fiberglass overwrap and samarium cobalt magnets); and the hydrostatic gas bearings (carbon graphite and aluminum oxide for wear couple surfaces). Tests on the CTPC were performed in three phases: cold end testing (525 K), engine testing with slot radiant heaters, and integrated heat pipe engine system testing. Each test phase was successful, with the integrated engine system demonstrating a power level of 12.5 kWe and an overall efficiency of 22 percent in its maiden test. A 1500-hour endurance test was then successfully completed. These results indicate the significant achievements made by this program that demonstrate the viability of Stirling engine technology for space applications.

Psychological Assessment Training in Clinical Psychology Doctoral Programs.

PubMed

Mihura, Joni L; Roy, Manali; Graceffo, Robert A

2017-01-01

We surveyed American Psychological Association-accredited clinical psychology doctoral programs' (n = 83) training in psychological assessment-specifically, their coverage of various assessment topics and tests in courses and practica, and whether the training was optional or required. We report results overall and separately per training model (clinical science, scientist-practitioner, and practitioner-focused). Overall, our results suggest that psychological assessment training is as active, or even more active, than in previous years. Areas of increased emphasis include clinical interviewing and psychometrics; multimethod, outcomes, health, and collaborative or therapeutic assessment; and different types of cognitive and self-report personality tests. All or almost all practice-focused programs offered training with the Thematic Apperception Test and Rorschach compared to about half of the scientist-practitioner programs and a third of the clinical science programs. Although almost all programs reported teaching multimethod assessment, what constitutes different methods of assessing psychopathology should be clarified in future studies because many programs appear to rely on one method-self-report (especially clinical science programs). Although doctoral programs covered many assessment topics and tests in didactic courses, there appears to be a shortage of program-run opportunities for students to obtain applied assessment training. Finally, we encourage doctoral programs to be familiar with (a) internships' assessment expectations and opportunities, (b) the professional guidelines for assessment training, and (c) the American Psychological Association's requirements for preinternship assessment competencies.

Annular Focused Electron/Ion Beams for Combining High Spatial Resolution with High Probe Current.

PubMed

Khursheed, Anjam; Ang, Wei Kean

2016-10-01

This paper presents a proposal for reducing the final probe size of focused electron/ion beam columns that are operated in a high primary beam current mode where relatively large final apertures are used, typically required in applications such as electron beam lithography, focused ion beams, and electron beam spectroscopy. An annular aperture together with a lens corrector unit is used to replace the conventional final hole-aperture, creating an annular ring-shaped primary beam. The corrector unit is designed to eliminate the first- and second-order geometric aberrations of the objective lens, and for the same probe current, the final geometric aberration limited spot size is predicted to be around a factor of 50 times smaller than that of the corresponding conventional hole-aperture beam. Direct ray tracing simulation is used to illustrate how a three-stage core lens corrector can be used to eliminate the first- and second-order geometric aberrations of an electric Einzel objective lens.

Testing For Measurement Invariance of Attachment Across Chinese and American Adolescent Samples.

PubMed

Ren, Ling; Zhao, Jihong Solomon; He, Ni Phil; Marshall, Ineke Haen; Zhang, Hongwei; Zhao, Ruohui; Jin, Cheng

2016-06-01

Adolescent attachment to formal and informal institutions has emerged as a major focus of criminological theories since the publication of Hirschi's work in 1969. This study attempts to examine the psychometric equivalence of the factorial structure of attachment measures across nations reflecting Western and Eastern cultures. Twelve manifest variables are used tapping the concepts of adolescent attachment to parents, school, and neighborhood. Confirmatory factor analysis is used to conduct invariance test across approximately 3,000 Chinese and U.S. adolescents. Results provide strong support for a three-factor model; the multigroup invariance tests reveal mixed results. While the family attachment measure appears invariant between the two samples, significant differences in the coefficients of the factor loadings are detected in the school attachment and neighborhood attachment measures. The results of regression analyses lend support to the predictive validity of three types of attachment. Finally, the limitations of the study are discussed. © The Author(s) 2015.

Analysis of detection performance of multi band laser beam analyzer

NASA Astrophysics Data System (ADS)

Du, Baolin; Chen, Xiaomei; Hu, Leili

2017-10-01

Compared with microwave radar, Laser radar has high resolution, strong anti-interference ability and good hiding ability, so it becomes the focus of laser technology engineering application. A large scale Laser radar cross section (LRCS) measurement system is designed and experimentally tested. First, the boundary conditions are measured and the long range laser echo power is estimated according to the actual requirements. The estimation results show that the echo power is greater than the detector's response power. Secondly, a large scale LRCS measurement system is designed according to the demonstration and estimation. The system mainly consists of laser shaping, beam emitting device, laser echo receiving device and integrated control device. Finally, according to the designed lidar cross section measurement system, the scattering cross section of target is simulated and tested. The simulation results are basically the same as the test results, and the correctness of the system is proved.

Centroid Detector Assembly for the AXAF-I Alignment Test System

NASA Technical Reports Server (NTRS)

Glenn, Paul

1995-01-01

The High Resolution Mirror Assembly (HRMA) of the Advanced X-ray Astrophysics Facility (imaging) (AXAF-I) consists of four nested paraboloids and four nested hyperboloids, all of meter-class size, and all of which are to be assembled and aligned in a special 15 meter tower at Eastman Kodak Company in Rochester, NY. The goals of the alignment are (1) to make the images of the four telescopes coincident; (2) to remove coma from each image individually; and (3) to control and determine the final position of the composite focus. This will be accomplished by the HRMA Aligment Test System (HATS) which is essentially a scanning Hartmann test system. The scanning laser source and the focal plane of the HATS are part of the Centroid Detector Assembly (CDA) which also includes processing electronics and software. In this paper we discuss the design and the measured performance of the CDA.

What scaling means in wind engineering: Complementary role of the reduced scale approach in a BLWT and the full scale testing in a large climatic wind tunnel

NASA Astrophysics Data System (ADS)

Flamand, Olivier

2017-12-01

Wind engineering problems are commonly studied by wind tunnel experiments at a reduced scale. This introduces several limitations and calls for a careful planning of the tests and the interpretation of the experimental results. The talk first revisits the similitude laws and discusses how they are actually applied in wind engineering. It will also remind readers why different scaling laws govern in different wind engineering problems. Secondly, the paper focuses on the ways to simplify a detailed structure (bridge, building, platform) when fabricating the downscaled models for the tests. This will be illustrated by several examples from recent engineering projects. Finally, under the most severe weather conditions, manmade structures and equipment should remain operational. What “recreating the climate” means and aims to achieve will be illustrated through common practice in climatic wind tunnel modelling.

Application of active magnetic bearings in flexible rotordynamic systems - A state-of-the-art review

NASA Astrophysics Data System (ADS)

Siva Srinivas, R.; Tiwari, R.; Kannababu, Ch.

2018-06-01

In this paper a critical review of literature on applications of Active Magnetic Bearings (AMBs) systems in flexible rotordynamic systems have been presented. AMBs find various applications in rotating machinery; however, this paper mainly focuses on works in vibration suppression and associated with the condition monitoring using AMBs. It briefly introduces reader to the AMB working principle, provides details of various hardware components of a typical rotor-AMB test rig, and presents a background of traditional methods of vibration suppression in flexible rotors and the condition monitoring. It then moves on to summarize the basic features of AMB integrated flexible rotor test rigs available in literature with necessary instrumentation and its main objectives. A couple of lookup tables provide summary of important information of test rigs in papers within the scope of this article. Finally, future directions in AMB research within the paper's scope have been suggested.

Laboratory testing in primary care: A systematic review of health IT impacts.

PubMed

Maillet, Éric; Paré, Guy; Currie, Leanne M; Raymond, Louis; Ortiz de Guinea, Ana; Trudel, Marie-Claude; Marsan, Josianne

2018-08-01

Laboratory testing in primary care is a fundamental process that supports patient management and care. Any breakdown in the process may alter clinical information gathering and decision-making activities and can lead to medical errors and potential adverse outcomes for patients. Various information technologies are being used in primary care with the goal to support the process, maximize patient benefits and reduce medical errors. However, the overall impact of health information technologies on laboratory testing processes has not been evaluated. To synthesize the positive and negative impacts resulting from the use of health information technology in each phase of the laboratory 'total testing process' in primary care. We conducted a systematic review. Databases including Medline, PubMed, CINAHL, Web of Science and Google Scholar were searched. Studies eligible for inclusion reported empirical data on: 1) the use of a specific IT system, 2) the impacts of the systems to support the laboratory testing process, and were conducted in 3) primary care settings (including ambulatory care and primary care offices). Our final sample consisted of 22 empirical studies which were mapped to a framework that outlines the phases of the laboratory total testing process, focusing on phases where medical errors may occur. Health information technology systems support several phases of the laboratory testing process, from ordering the test to following-up with patients. This is a growing field of research with most studies focusing on the use of information technology during the final phases of the laboratory total testing process. The findings were largely positive. Positive impacts included easier access to test results by primary care providers, reduced turnaround times, and increased prescribed tests based on best practice guidelines. Negative impacts were reported in several studies: paper-based processes employed in parallel to the electronic process increased the potential for medical errors due to clinicians' cognitive overload; systems deemed not reliable or user-friendly hampered clinicians' performance; and organizational issues arose when results tracking relied on the prescribers' memory. The potential of health information technology lies not only in the exchange of health information, but also in knowledge sharing among clinicians. This review has underscored the important role played by cognitive factors, which are critical in the clinician's decision-making, the selection of the most appropriate tests, correct interpretation of the results and efficient interventions. By providing the right information, at the right time to the right clinician, many IT solutions adequately support the laboratory testing process and help primary care clinicians make better decisions. However, several technological and organizational barriers require more attention to fully support the highly fragmented and error-prone process of laboratory testing. Copyright © 2018 Elsevier B.V. All rights reserved.

Design and development of a quad copter (UMAASK) using CAD/CAM/CAE

NASA Astrophysics Data System (ADS)

Manarvi, Irfan Anjum; Aqib, Muhammad; Ajmal, Muhammad; Usman, Muhammad; Khurshid, Saqib; Sikandar, Usman

Micro flying vehicles1 (MFV) have become a popular area of research due to economy of production, flexibility of launch and variety of applications. A large number of techniques from pencil sketching to computer based software are being used for designing specific geometries and selection of materials to arrive at novel designs for specific requirements. Present research was focused on development of suitable design configuration using CAD/CAM/CAE tools and techniques. A number of designs were reviewed for this purpose. Finally, rotary wing Quadcopter flying vehicle design was considered appropriate for this research. Performance requirements were planned as approximately 10 meters ceiling, weight less than 500grams and ability to take videos and pictures. Parts were designed using Finite Element Analysis, manufactured using CNC machines and assembled to arrive at final design named as UMAASK. Flight tests were carried out which confirmed the design requirements.

Antibody to HTLV‐I in Indigenous Inhabitants of the Andes and Amazon Regions in Colombia

PubMed Central

Zamora, Tomas; Zaninovic, Vladimir; Kajiwara, Masaharu; Komoda, Haruko; Hayami, Masanori

1990-01-01

To explore the HTLV‐I‐carrying groups among the indigenous inhabitants in South America, a sero‐epidemiological study on HTLV‐I focusing on hinterland villages isolated from others in the Andes and Amazon regions was conducted. Five (2.9%) out of 171 subjects showed positive for HTLV‐I antibody in the gelatin particle agglutination (PA) test. Two out of 5 positives with high antibody titer (≫× 1024) in the PA test also showed a positive immunofluorescence (IF) test and anti‐HTLV‐I‐specific protein products, p19, p24, p28, gp46, and p53 in sera by the Western blotting (WB) test. One of three negatives in the IF test showed positive antibodies to p19 and p24 by the WB test. Finally, two were confirmed as HTLV‐I carriers and one was suspected of being a carrier. All three are Paez Indians from the central Andes; 53‐ and 34‐year‐old women and a 35‐year‐old man. The results show that HTLV‐1 carriers exist among isolated indigenous people in South America. PMID:1975804

Colorectal cancer screening: An updated review of the available options.

PubMed

Issa, Iyad A; Noureddine, Malak

2017-07-28

Colorectal cancer (CRC) is a significant cause of morbidity and mortality worldwide. However, colon cancer incidence and mortality is declining over the past decade owing to adoption of effective screening programs. Nevertheless, in some parts of the world, CRC incidence and mortality remain on the rise, likely due to factors including "westernized" diet, lifestyle, and lack of health-care infrastructure and resources. Participation and adherence to different national screening programs remain obstacles limiting the achievement of screening goals. Different modalities are available ranging from stool based tests to radiology and endoscopy with varying sensitivity and specificity. However, the availability of these tests is limited to areas with high economic resources. Recently, FDA approved a blood-based test (Epi procolon ® ) for CRC screening. This blood based test may serve to increase the participation and adherence rates. Hence, leading to increase in colon cancer detection and prevention. This article will discuss various CRC screening tests with a particular focus on the data regarding the new approved blood test. Finally, we will propose an algorithm for a simple cost-effective CRC screening program.

Colorectal cancer screening: An updated review of the available options

PubMed Central

Issa, Iyad A; Noureddine, Malak

2017-01-01

Colorectal cancer (CRC) is a significant cause of morbidity and mortality worldwide. However, colon cancer incidence and mortality is declining over the past decade owing to adoption of effective screening programs. Nevertheless, in some parts of the world, CRC incidence and mortality remain on the rise, likely due to factors including “westernized” diet, lifestyle, and lack of health-care infrastructure and resources. Participation and adherence to different national screening programs remain obstacles limiting the achievement of screening goals. Different modalities are available ranging from stool based tests to radiology and endoscopy with varying sensitivity and specificity. However, the availability of these tests is limited to areas with high economic resources. Recently, FDA approved a blood-based test (Epi procolon®) for CRC screening. This blood based test may serve to increase the participation and adherence rates. Hence, leading to increase in colon cancer detection and prevention. This article will discuss various CRC screening tests with a particular focus on the data regarding the new approved blood test. Finally, we will propose an algorithm for a simple cost-effective CRC screening program. PMID:28811705

Verb-based versus class-based accounts of actionality effects in children's comprehension of passives.

PubMed

Gordon, P; Chafetz, J

1990-09-01

Several studies have shown that children perform worse on tests of passive comprehension when the verb is non-actional than when it is actional. Most existing accounts focus on the semantic characteristics of the class of non-action verbs in explaining this difference. An alternative is a "verb-based" account in which passives are initially learned verb by verb, and children hear fewer non-actional passives in their language input. An analysis of the passives heard by Adam, Eve and Sarah (Brown, 1973) found more actional than non-actional passives, consistent with the verb-based account. In a second study, children tested for passive comprehension were re-tested a week later. The verb-based account predicts that children should show a consistent pattern of responses for individual verbs on test and re-test. Such consistency was found, with some inconsistency due to improvement over the re-test. Further analyses showed no effects of affectedness in explaining children's problems with passives. Finally, we discuss whether a mixed model containing both verb-based and class-based mechanisms is required to explain the actionality effects.

Transfer-appropriate processing in the testing effect.

PubMed

Veltre, Mary T; Cho, Kit W; Neely, James H

2015-01-01

The testing effect is the finding that taking a review test enhances performance on a final test relative to restudying the material. The present experiment investigated transfer-appropriate processing in the testing effect using semantic and orthographic cues to evoke conceptual and data-driven processing, respectively. After a study phase, subjects either restudied the material or took a cued-recall test consisting of half semantic and half orthographic cues in which the correct response was given as feedback. A final, cued-recall test consisted of the identical cue, or a new cue that was of the same type or different type of cue (semantic/orthographic or orthographic/semantic) as that used for that target in the review test. Testing enhanced memory in all conditions. When the review cues and final-test cues were identical, final recall was higher for semantic than orthographic cues. Consistent with test-based transfer-appropriate processing, memory performance improved as the review and final cues became more similar. These results suggest that the testing effect could potentially be caused by the episodic retrieval processes in a final memory test overlapping more with the episodic retrieval processes in a review test than with the encoding operations performed during restudy.

Focusing Electron Beams at SLAC.

ERIC Educational Resources Information Center

Taylor, Richard L.

1993-01-01

Describes the development of a set of magnets that focus high-energy electron and positron beams causing them to collide, annihilate each other, and generate new particles. Explains how dipoles bend the beam, how quadrupoles focus the beam, how the focal length is calculated, and the superconducting final focus. (MDH)

An engineering methodology for implementing and testing VLSI (Very Large Scale Integrated) circuits

NASA Astrophysics Data System (ADS)

Corliss, Walter F., II

1989-03-01

The engineering methodology for producing a fully tested VLSI chip from a design layout is presented. A 16-bit correlator, NPS CORN88, that was previously designed, was used as a vehicle to demonstrate this methodology. The study of the design and simulation tools, MAGIC and MOSSIM II, was the focus of the design and validation process. The design was then implemented and the chip was fabricated by MOSIS. This fabricated chip was then used to develop a testing methodology for using the digital test facilities at NPS. NPS CORN88 was the first full custom VLSI chip, designed at NPS, to be tested with the NPS digital analysis system, Tektronix DAS 9100 series tester. The capabilities and limitations of these test facilities are examined. NPS CORN88 test results are included to demonstrate the capabilities of the digital test system. A translator, MOS2DAS, was developed to convert the MOSSIM II simulation program to the input files required by the DAS 9100 device verification software, 91DVS. Finally, a tutorial for using the digital test facilities, including the DAS 9100 and associated support equipments, is included as an appendix.

Some problems with social cognition models: a pragmatic and conceptual analysis.

PubMed

Ogden, Jane

2003-07-01

Empirical articles published between 1997 and 2001 from 4 health psychology journals that tested or applied 1 or more social cognition models (theory of reasoned action, theory of planned behavior, health belief model, and protection motivation theory; N = 47) were scrutinized for their pragmatic and conceptual basis. In terms of their pragmatic basis, these 4 models were useful for guiding research. The analysis of their conceptual basis was less positive. First, these models do not enable the generation of hypotheses because their constructs are unspecific; they therefore cannot be tested. Second, they focus on analytic truths rather than synthetic ones, and the conclusions resulting from their application are often true by definition rather than by observation. Finally, they may create and change both cognitions and behavior rather than describe them.

IOTA (Integrable Optics Test Accelerator): Facility and experimental beam physics program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Antipov, Sergei; Broemmelsiek, Daniel; Bruhwiler, David

The Integrable Optics Test Accelerator (IOTA) is a storage ring for advanced beam physics research currently being built and commissioned at Fermilab. It will operate with protons and electrons using injectors with momenta of 70 and 150 MeV/c, respectively. The research program includes the study of nonlinear focusing integrable optical beam lattices based on special magnets and electron lenses, beam dynamics of space-charge effects and their compensation, optical stochastic cooling, and several other experiments. In this article, we present the design and main parameters of the facility, outline progress to date and provide the timeline of the construction, commissioning andmore » research. Finally, the physical principles, design, and hardware implementation plans for the major IOTA experiments are also discussed.« less

IOTA (Integrable Optics Test Accelerator): Facility and experimental beam physics program

DOE PAGES

Antipov, Sergei; Broemmelsiek, Daniel; Bruhwiler, David; ...

2017-03-06

The Integrable Optics Test Accelerator (IOTA) is a storage ring for advanced beam physics research currently being built and commissioned at Fermilab. It will operate with protons and electrons using injectors with momenta of 70 and 150 MeV/c, respectively. The research program includes the study of nonlinear focusing integrable optical beam lattices based on special magnets and electron lenses, beam dynamics of space-charge effects and their compensation, optical stochastic cooling, and several other experiments. In this article, we present the design and main parameters of the facility, outline progress to date and provide the timeline of the construction, commissioning andmore » research. Finally, the physical principles, design, and hardware implementation plans for the major IOTA experiments are also discussed.« less

Development and application of dynamic simulations of a subsonic wind tunnel

NASA Technical Reports Server (NTRS)

Szuch, J. R.; Cole, G. L.; Seidel, R. C.; Arpasi, D. J.

1986-01-01

Efforts are currently underway at NASA Lewis to improve and expand ground test facilities and to develop supporting technologies to meet anticipated aeropropulsion research needs. Many of these efforts have been focused on a proposed rehabilitation of the Altitude Wind Tunnel (AWT). In order to insure a technically sound design, an AWT modeling program (both analytical and physical) was initiated to provide input to the AWT final design process. This paper describes the approach taken to develop analytical, dynamic computer simulations of the AWT, and the use of these simulations as test-beds for: (1) predicting the dynamic response characteristics of the AWT, and (2) evaluating proposed AWT control concepts. Plans for developing a portable, real-time simulator for the AWT facility are also described.

Stereotype content model explains prejudice for an envied outgroup: Scale of anti-Asian American Stereotypes.

PubMed

Lin, Monica H; Kwan, Virginia S Y; Cheung, Anna; Fiske, Susan T

2005-01-01

The Stereotype Content Model hypothesizes anti-Asian American stereotypes differentiating two dimensions: (excessive) competence and (deficient) sociability. The Scale of Anti-Asian American Stereotypes (SAAAS) shows this envious mixed prejudice in six studies. Study 1 began with 131 racial attitude items. Studies 2 and 3 tested 684 respondents on a focused 25-item version. Studies 4 and 5 tested the final 25-item SAAAS on 222 respondents at three campuses; scores predicted outgroup friendships, cultural experiences, and (over)estimated campus presence. Study 6 showed that allegedly low sociability, rather than excessively high competence, drives rejection of Asian Americans, consistent with system justification theory. The SAAAS demonstrates mixed, envious anti-Asian American prejudice, contrasting with more-often-studied contemptuous racial prejudices (i.e., against Blacks).

FAST Model Calibration and Validation of the OC5-DeepCwind Floating Offshore Wind System Against Wave Tank Test Data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wendt, Fabian F; Robertson, Amy N; Jonkman, Jason

During the course of the Offshore Code Comparison Collaboration, Continued, with Correlation (OC5) project, which focused on the validation of numerical methods through comparison against tank test data, the authors created a numerical FAST model of the 1:50-scale DeepCwind semisubmersible system that was tested at the Maritime Research Institute Netherlands ocean basin in 2013. This paper discusses several model calibration studies that were conducted to identify model adjustments that improve the agreement between the numerical simulations and the experimental test data. These calibration studies cover wind-field-specific parameters (coherence, turbulence), hydrodynamic and aerodynamic modeling approaches, as well as rotor model (blade-pitchmore » and blade-mass imbalances) and tower model (structural tower damping coefficient) adjustments. These calibration studies were conducted based on relatively simple calibration load cases (wave only/wind only). The agreement between the final FAST model and experimental measurements is then assessed based on more-complex combined wind and wave validation cases.« less

Validation of powder X-ray diffraction following EN ISO/IEC 17025.

PubMed

Eckardt, Regina; Krupicka, Erik; Hofmeister, Wolfgang

2012-05-01

Powder X-ray diffraction (PXRD) is used widely in forensic science laboratories with the main focus of qualitative phase identification. Little is found in literature referring to the topic of validation of PXRD in the field of forensic sciences. According to EN ISO/IEC 17025, the method has to be tested for several parameters. Trueness, specificity, and selectivity of PXRD were tested using certified reference materials or a combination thereof. All three tested parameters showed the secure performance of the method. Sample preparation errors were simulated to evaluate the robustness of the method. These errors were either easily detected by the operator or nonsignificant for phase identification. In case of the detection limit, a statistical evaluation of the signal-to-noise ratio showed that a peak criterion of three sigma is inadequate and recommendations for a more realistic peak criterion are given. Finally, the results of an international proficiency test showed the secure performance of PXRD. © 2012 American Academy of Forensic Sciences.

Simulation and experiment for the inspection of stainless steel bolts in servicing using an ultrasonic phased array

NASA Astrophysics Data System (ADS)

Chen, Jinzhong; He, Renyang; Kang, Xiaowei; Yang, Xuyun

2015-10-01

The non-destructive testing of small-sized (M12-M20) stainless steel bolts in servicing is always a technical problem. This article focuses on the simulation and experimental research of stainless steel bolts with an artificial defect reflector using ultrasonic phased array inspection. Based on the observation of the sound field distribution of stainless steel bolts in ultrasonic phased array as well as simulation modelling and analysis of the phased array probes' detection effects with various defect sizes, different artificial defect reflectors of M16 stainless steel bolts are machined in reference to the simulation results. Next, those bolts are tested using a 10-wafer phased array probe with 5 MHz. The test results finally prove that ultrasonic phased array can detect 1-mm cracks in diameter with different depths of M16 stainless steel bolts and a metal loss of Φ1 mm of through-hole bolts, which provides technical support for future non-destructive testing of stainless steel bolts in servicing.

Tests Enhance the Transfer of Learning

ERIC Educational Resources Information Center

Rohrer, Doug; Taylor, Kelli; Sholar, Brandon

2010-01-01

Numerous learning studies have shown that if the period of time devoted to studying information (e.g., casa-house) includes at least 1 test (casa-?), performance on a final test is improved--a finding known as the "testing effect". In most of these studies, however, the final test is identical to the initial test. If the final test…

Analytical approach to chromatic correction in the final focus system of circular colliders

DOE PAGES

Cai, Yunhai

2016-11-28

Here, a conventional final focus system in particle accelerators is systematically analyzed. We find simple relations between the parameters of two focus modules in the final telescope. Using the relations, we derive the chromatic Courant-Snyder parameters for the telescope. The parameters are scaled approximately according to (L*/βmore » $$*\\atop{y}$$)δ, where L* is the distance from the interaction point to the first quadrupole, β$$*\\atop{y}$$ the vertical beta function at the interaction point, and δ the relative momentum deviation. Most importantly, we show how to compensate its chromaticity order by order in δ by a traditional correction module flanked by an asymmetric pair of harmonic multipoles. The method enables a circular Higgs collider with 2% momentum aperture and illuminates a path forward to 4% in the future.« less

The Unexpected Relationship Between Retrieval Demands and Memory Performance When Older Adults are Faced with Age-Related Stereotypes.

PubMed

Thomas, Ayanna K; Smith, Amy M; Mazerolle, Marie

2018-03-28

In two studies, we examined the effects of age-related stereotype threat on eyewitness memory using the misinformation paradigm to (1) examine stereotype threat in the context of a more ecologically valid memory task and (2) determine the relationship between task difficulty and susceptibility to stereotype threat. After watching a video that depicted a crime, older and younger adult participants were presented with a written synopsis in which information consistent or inconsistent with the original event was presented. Half of the participants were then presented with information designed to activate negative stereotypes about aging. Finally, participants completed a memory test. In Study 1, when participants were instructed to report information from either the video or the synopsis to complete the final memory test, older adults under high stereotype threat were less accurate than those under low threat. In Study 2, when participants were required to engage in more controlled processes at retrieval and respond with only video information, older adults under stereotype threat performed as well or better than those under low threat. The results are consistent with the Regulatory Focus Model of Stereotype Threat.

Development and psychometric evaluation of the Dialysis patient-perceived Exercise Benefits and Barriers Scale.

PubMed

Zheng, Jing; You, Li-Ming; Lou, Tan-Qi; Chen, Nian-Chang; Lai, De-Yuan; Liang, Yan-Yi; Li, Ying-Na; Gu, Ying-Ming; Lv, Shao-Fen; Zhai, Cui-Qiu

2010-02-01

Perceptions of exercise benefits and barriers affect exercise behavior. Because of the clinical course and treatment, dialysis patients differ from the general population in their perceptions of exercise benefits and barriers, especially the latter. At present, no valid instruments for assessing perceived exercise benefits and barriers in dialysis patients are available. Our goal was to develop and test the psychometric properties of the Dialysis patient-perceived Exercise Benefits and Barriers Scale (DPEBBS). A literature review and two focus groups were conducted to generate the initial item pool. An expert panel examined the content validity. Then, 269 Chinese hemodialysis patients were recruited by convenience sampling. Exploratory and confirmatory factor analyses were used to test construct validity. Finally, internal consistency and test-retest reliability were assessed. The expert panel determined that the content validity index was satisfactory. The final 24-item scale consisted of six factors explaining 57% of the total variance in the data. Confirmative factor analysis supported the six-factor structure and a higher-order model. Cronbach's alpha was 0.87 for the total scale, and 0.84 for test-retest reliability. The DPEBBS was a valid and reliable instrument for evaluating dialysis patients' perceived benefits and barriers to exercise. The application value of this scale remains to be investigated by increasing the sample size and evaluating patients undergoing different dialysis modalities and coming from different regions and cultural backgrounds. Copyright 2009 Elsevier Ltd. All rights reserved.

Evaluation of interactions between soil and coal fly ash leachates using column percolation tests.

PubMed

Tsiridis, V; Petala, M; Samaras, P; Sakellaropoulos, G P

2015-09-01

The aim of this work was the assessment of the environmental impact of different origin fly ashes with regard to their final disposal. The experimental procedure included the performance of single column tests and column tests of fly ash and soil in series. The appraisal of the potential environmental hazards was implemented using physicochemical analyses and bioassays. Two different fly ash samples were examined, one fly ash produced from the combustion of sub-bituminous coal (CFA) and one fly ash produced from the combustion of lignite (LFA). Single column percolation tests were performed according to NEN 7343 protocol, while fly ash/soil experiments were conducted incorporating slight modifications to this protocol. The study focused on the release of metals Ba, Cr, Cu, Mo, Se and Zn and the ecotoxic behavior of leachates on crustacean Daphnia magna and bacteria Vibrio fischeri. The infiltration of the leachates of both fly ashes through soil affected considerably their leaching profile. The transport of Cu and Zn was facilitated by the dynamic leaching conditions and influenced by the pH of the leachates. Moreover, the release and bioavailability of Cr, Cu and Zn was probably altered during the infiltration experiments and organisms' response was not always correlated with the concentration of metals. Nevertheless, the results are signalling that possible manipulations and final disposal of fly ash should be considered when environmental threats are investigated. Copyright © 2015 Elsevier Ltd. All rights reserved.

Evaluation of Item Candidates: The PROMIS Qualitative Item Review

PubMed Central

DeWalt, Darren A.; Rothrock, Nan; Yount, Susan; Stone, Arthur A.

2009-01-01

One of the PROMIS (Patient-Reported Outcome Measurement Information System) network's primary goals is the development of a comprehensive item bank for patient-reported outcomes of chronic diseases. For its first set of item banks, PROMIS chose to focus on pain, fatigue, emotional distress, physical function, and social function. An essential step for the development of an item pool is the identification, evaluation, and revision of extant questionnaire items for the core item pool. In this work, we also describe the systematic process wherein items are classified for subsequent statistical processing by the PROMIS investigators. Six phases of item development are documented: identification of extant items, item classification and selection, item review and revision, focus group input on domain coverage, cognitive interviews with individual items, and final revision before field testing. Identification of items refers to the systematic search for existing items in currently available scales. Expert item review and revision was conducted by trained professionals who reviewed the wording of each item and revised as appropriate for conventions adopted by the PROMIS network. Focus groups were used to confirm domain definitions and to identify new areas of item development for future PROMIS item banks. Cognitive interviews were used to examine individual items. Items successfully screened through this process were sent to field testing and will be subjected to innovative scale construction procedures. PMID:17443114

A Project to Design and Build the Magnets for a New Test Beamline, the ATF2, at KEK

DOE Office of Scientific and Technical Information (OSTI.GOV)

Spencer, Cherrill M.; /slac; Sugahara, Ryuhei

2011-02-07

In order to achieve the high luminosity required at the proposed International Linear Collider (ILC), it is critical to focus the beams to nanometer size with the ILC Beam Delivery System, and to maintain the beams collisions with a nanometer-scale stability. To establish the technologies associated with this ultra-high precision beam handling, a special beamline has been designed and built as an extension of the existing extraction beamline of the Accelerator Test Facility at KEK, Japan. The ATF provides an adequate ultra-low emittance electron beam that is comparable to the ILC requirements; the ATF2 mimics the ILC final focus systemmore » to create a tightly focused, stable beam. There are 37 magnets in the ATF2, 29 quadrupoles, 5 sextupoles and 3 bends. These magnets had to be acquired in a short time and at minimum cost, which led to various acquisition strategies; but nevertheless they had to meet strict requirements on integrated strength, physical dimensions, compatibility with existing magnet movers and beam position monitors, mechanical stability and field stability and quality. This paper will describe how 2 styles of quadrupoles, 2 styles of sextupoles, one dipole style and their supports were designed, fabricated, refurbished or modified, measured and aligned by a small team of engineers from 3 continents.« less

Consensus and controversies in best practices for molecular genetic testing of spinocerebellar ataxias

PubMed Central

Sequeiros, Jorge; Seneca, Sara; Martindale, Joanne

2010-01-01

Many laboratories worldwide are offering molecular genetic testing for spinocerebellar ataxias (SCAs). This is essential for differential diagnosis and adequate genetic counselling. The European Molecular Genetics Quality Network (EMQN) started an SCA external quality assessment scheme in 2004. There was a clear need for updated laboratory guidelines. EMQN and EuroGentest organized a Best Practice (BP) meeting to discuss current practices and achieve consensus. A pre-meeting survey showed that 36 laboratories (20 countries) conducted nearly 18 000 SCA tests the year before, and identified issues to discuss. Draft guidelines were produced immediately after the meeting and discussed online for several months. The final version was endorsed by EMQN, and harmonized with guidelines from other oligonucleotide repeat disorders. We present the procedures taken to organize the survey, BP meeting, as well as drafting and approval of BP guidelines. We emphasize the most important recommendations on (1) pre-test requirements, (2) appropriate methodologies and (3) interpretation and reporting, and focus on the discussion of controversial issues not included in the final document. In addition, after an extensive review of scientific literature, and responding to recommendations made, we now produce information that we hope will facilitate the activities of diagnostic laboratories and foster quality SCA testing. For the main loci, this includes (1) a list of repeat sequences, as originally published; (2) primers in use; and (3) an evidence-based description of the normal and pathogenic repeat-size ranges, including those of reduced penetrance and those in which there is still some uncertainty. This information will be maintained and updated in http://www.scabase.eu. PMID:20179748

Progress in the development and integration of fluid flow control tools in paper microfluidics.

PubMed

Fu, Elain; Downs, Corey

2017-02-14

Paper microfluidics is a rapidly growing subfield of microfluidics in which paper-like porous materials are used to create analytical devices. There is a need for higher performance field-use tests for many application domains including human disease diagnosis, environmental monitoring, and veterinary medicine. A key factor in creating high performance paper-based devices is the ability to manipulate fluid flow within the devices. This critical review is focused on the progress that has been made in (i) the development of fluid flow control tools and (ii) the integration of those tools into paper microfluidic devices. Further, we strive to be comprehensive in our presentation and provide historical context through discussion and performance comparisons, when possible, of both relevant earlier work and recent work. Finally, we discuss the major areas of focus for fluid flow methods development to advance the potential of paper microfluidics for high-performance field applications.

Effects of Psychological Attention on Pronoun Comprehension

PubMed Central

Arnold, Jennifer E.; Lao, Shin-Yi C.

2015-01-01

Pronoun comprehension is facilitated for referents that are focused in the discourse context. Discourse focus has been described as a function of attention, especially shared attention, but few studies have explicitly tested this idea. Two experiments used an exogenous capture cue paradigm to demonstrate that listeners’ visual attention at the onset of a story influences their preferences during pronoun resolution later in the story. In both experiments trial-initial attention modulated listeners’ transitory biases while considering referents for the pronoun, whether it was in response to the capture cue or not. These biases even had a small influence on listeners’ final interpretation of the pronoun. These results provide independently-motivated evidence that the listener’s attention influences the on-line processes of pronoun comprehension. Trial-initial attentional shifts were made on the basis of non-shared, private information, demonstrating that attentional effects on pronoun comprehension are not restricted to shared attention among interlocutors. PMID:26191533

"Letting myself go forward past wrongs": How regulatory modes affect self-forgiveness

PubMed Central

Giannini, Anna Maria; Higgins, E. Tory; Kruglanski, Arie W.

2018-01-01

The present research addresses the question of whether regulatory-mode orientations affect self-forgiveness. We expected that people with a strong locomotion orientation would be more inclined to self-forgiveness because of their tendencies toward movement and change, which focus them on the future, whereas people with a strong assessment orientation would refrain from self-forgiveness due to their evaluative tendencies which focus them on the past. These hypotheses were supported by the results in four studies that tested the relation between regulatory modes and self-forgiveness by measuring (Studies 1, 3 and 4) and manipulating (Study 2) regulatory-mode-orientations. Finally, in Study 4 we examined more closely our hypothesis that the relation between self-forgiveness and regulatory modes is mediated by past and future temporal foci. The implications of the results for regulatory mode theory are also discussed. PMID:29529065

Reconstruction of refocusing and all-in-focus images based on forward simulation model of plenoptic camera

NASA Astrophysics Data System (ADS)

Zhang, Rumin; Liu, Peng; Liu, Dijun; Su, Guobin

2015-12-01

In this paper, we establish a forward simulation model of plenoptic camera which is implemented by inserting a micro-lens array in a conventional camera. The simulation model is used to emulate how the space objects at different depths are imaged by the main lens then remapped by the micro-lens and finally captured on the 2D sensor. We can easily modify the parameters of the simulation model such as the focal lengths and diameters of the main lens and micro-lens and the number of micro-lens. Employing the spatial integration, the refocused images and all-in-focus images are rendered based on the plenoptic images produced by the model. The forward simulation model can be used to determine the trade-offs between different configurations and to test any new researches related to plenoptic camera without the need of prototype.

"Letting myself go forward past wrongs": How regulatory modes affect self-forgiveness.

PubMed

Pierro, Antonio; Pica, Gennaro; Giannini, Anna Maria; Higgins, E Tory; Kruglanski, Arie W

2018-01-01

The present research addresses the question of whether regulatory-mode orientations affect self-forgiveness. We expected that people with a strong locomotion orientation would be more inclined to self-forgiveness because of their tendencies toward movement and change, which focus them on the future, whereas people with a strong assessment orientation would refrain from self-forgiveness due to their evaluative tendencies which focus them on the past. These hypotheses were supported by the results in four studies that tested the relation between regulatory modes and self-forgiveness by measuring (Studies 1, 3 and 4) and manipulating (Study 2) regulatory-mode-orientations. Finally, in Study 4 we examined more closely our hypothesis that the relation between self-forgiveness and regulatory modes is mediated by past and future temporal foci. The implications of the results for regulatory mode theory are also discussed.

Characterization and visual illustration of the consequences motion of human body for the determination of heart rate

NASA Astrophysics Data System (ADS)

Nedoma, Jan; Fajkus, Marcel; Martinek, Radek; Kepak, Stanislav; Cubik, Jakub; Vasinek, Vladimir

2017-10-01

The team of authors focused on analyzing of using fiber-optic sensor based on Fiber Bragg Grating (FBG) for the monitoring of heart rate (HR) of long-term ill patients with a minimum of physical movement load. During all experiments, test subjects were asked to simulate their natural behavior in the most accurate way (for instance, the focus was on the use of fine motor skills - not only movements of hands and arms, legs, and feet, coughing, changes in body positions, but also walking). All these external aspects are taken into account in the bellow-described results of the probe efficiency and show that it is very necessary to know the impact of these artifacts for the determine the heart rate of the human body. Final results were discussed with the senior doctor of the long-term care department.

The Uncertainty Response in Animal-Metacognition Researchers

PubMed Central

Beran, Michael J.; Smith, J. David

2014-01-01

Kornell (2013) considers whether and in what sense animals may be considered metacognitive. He questions whether tests that rely on animals assessing their internal memory strength can provide useful data. He offers his own strategies for determining what internal cues animals use in making metacognitive judgments. We endorse his call for an increased focus on animals' metacognitive errors as true reflections of metacognitive states shorn of associative bases. We endorse a sharper focus on information-processing analyses of the executive or attentional level that metacognitive responses may occupy in animals’ cognitive systems. Some of these analyses are being implemented in contemporary research, with positive results. Finally, we endorse the possibility that metacognition may not be an all-or-none thing, so that animals may share some facets—but not all facets—of metacognitive experience with humans. Kornell’s interesting contribution makes clear that in this area the animal-metacognition literature needs further theoretical sharpening. PMID:24866007

Luminescent characteristics study of Mather-type dense plasma focus and applications to short-wavelength optical pumping. Final technical report, 1 May 1984-30 September 1985

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, K.K.

A Mather-type dense plasma focus (MDPF) system was designed, built, and tested specifically to study its luminescent characteristics and to assess its potential as a new light source of high-energy, short-wavelength lasers. The luminescence study of MDPF showed that the conversion efficiency from the electrical input to the optical output energies is at least 50%, up to the time the plasma compression is complete. Using the system, for the first time as an optical pump, laser activities were successfully obtained from a variety of liquid organic dyes. Diagnostic capabilities included an optical multichannel analyzer system complete with a computer control,more » a nitrogen-pumped tunable dye-laser system, a high-speed streak/framing camera, a digital laser energy meter, voltage and current probes, and a computer-based data-acquisition system.« less

C-Band Airport Surface Communications System Standards Development. Phase II Final Report. Volume 2: Test Bed Performance Evaluation and Final AeroMACS Recommendations

NASA Technical Reports Server (NTRS)

Hall, Edward; Magner, James

2011-01-01

This report is provided as part of ITT s NASA Glenn Research Center Aerospace Communication Systems Technical Support (ACSTS) contract NNC05CA85C, Task 7: New ATM Requirements-Future Communications, C-Band and L-Band Communications Standard Development and was based on direction provided by FAA project-level agreements for New ATM Requirements-Future Communications. Task 7 included two subtasks. Subtask 7-1 addressed C-band (5091- to 5150-MHz) airport surface data communications standards development, systems engineering, test bed and prototype development, and tests and demonstrations to establish operational capability for the Aeronautical Mobile Airport Communications System (AeroMACS). Subtask 7-2 focused on systems engineering and development support of the L-band digital aeronautical communications system (L-DACS). Subtask 7-1 consisted of two phases. Phase I included development of AeroMACS concepts of use, requirements, architecture, and initial high-level safety risk assessment. Phase II builds on Phase I results and is presented in two volumes. Volume I is devoted to concepts of use, system requirements, and architecture, including AeroMACS design considerations. Volume II (this document) describes an AeroMACS prototype evaluation and presents final AeroMACS recommendations. This report also describes airport categorization and channelization methodologies. The purposes of the airport categorization task were (1) to facilitate initial AeroMACS architecture designs and enable budgetary projections by creating a set of airport categories based on common airport characteristics and design objectives, and (2) to offer high-level guidance to potential AeroMACS technology and policy development sponsors and service providers. A channelization plan methodology was developed because a common global methodology is needed to assure seamless interoperability among diverse AeroMACS services potentially supplied by multiple service providers.

Development and psychometric characteristics of the SCI-QOL Bladder Management Difficulties and Bowel Management Difficulties item banks and short forms and the SCI-QOL Bladder Complications scale.

PubMed

Tulsky, David S; Kisala, Pamela A; Tate, Denise G; Spungen, Ann M; Kirshblum, Steven C

2015-05-01

To describe the development and psychometric properties of the Spinal Cord Injury--Quality of Life (SCI-QOL) Bladder Management Difficulties and Bowel Management Difficulties item banks and Bladder Complications scale. Using a mixed-methods design, a pool of items assessing bladder and bowel-related concerns were developed using focus groups with individuals with spinal cord injury (SCI) and SCI clinicians, cognitive interviews, and item response theory (IRT) analytic approaches, including tests of model fit and differential item functioning. Thirty-eight bladder items and 52 bowel items were tested at the University of Michigan, Kessler Foundation Research Center, the Rehabilitation Institute of Chicago, the University of Washington, Craig Hospital, and the James J. Peters VA Medical Center, Bronx, NY. Seven hundred fifty-seven adults with traumatic SCI. The final item banks demonstrated unidimensionality (Bladder Management Difficulties CFI=0.965; RMSEA=0.093; Bowel Management Difficulties CFI=0.955; RMSEA=0.078) and acceptable fit to a graded response IRT model. The final calibrated Bladder Management Difficulties bank includes 15 items, and the final Bowel Management Difficulties item bank consists of 26 items. Additionally, 5 items related to urinary tract infections (UTI) did not fit with the larger Bladder Management Difficulties item bank but performed relatively well independently (CFI=0.992, RMSEA=0.050) and were thus retained as a separate scale. The SCI-QOL Bladder Management Difficulties and Bowel Management Difficulties item banks are psychometrically robust and are available as computer adaptive tests or short forms. The SCI-QOL Bladder Complications scale is a brief, fixed-length outcomes instrument for individuals with a UTI.

77 FR 15750 - Final Test Guidelines; OCSPP 810 Series; Notice of Availability

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-16

... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2009-0681; FRL-9332-4] Final Test Guidelines; OCSPP.... SUMMARY: EPA is announcing the availability of the final test guidelines for Series 810--Product Performance Test Guidelines, specifically public health uses of antimicrobial agents (OCSPP 810.2000...

21 CFR 610.12 - Sterility.

Code of Federal Regulations, 2011 CFR

2011-04-01

... container material. (a) The test. Bulk material shall be tested separately from final container material and material from each final container shall be tested in individual test vessels as follows: (1) Using Fluid Thioglycollate Medium—(i) Bulk and final container material. The volume of product, as required by paragraph (d...

Design, Fabrication, and Testing of a Composite Rack Prototype in Support of the Deep Space Habitat Program

NASA Technical Reports Server (NTRS)

Smith, Russ; Hagen, Richard

2015-01-01

In support of the Deep Space Habitat project a number of composite rack prototypes were developed, designed, fabricated and tested to various extents ( with the International Standard Payload Rack configuration, or crew quarters, as a baseline). This paper focuses specifically on a composite rack prototype with a direct tie in to Space Station hardware. The outlined prototype is an all composite construction, excluding metallic fasteners, washers, and their associated inserts. The rack utilizes braided carbon composite tubing for the frame with the sidewalls, backwall and flooring sections utilizing aircraft grade composite honeycomb sandwich panels. Novel additively manufactured thermoplastic joints and tube inserts were also developed in support of this effort. Joint and tube insert screening tests were conducted at a preliminary level. The screening tests allowed for modification, and enhancement, of the fabrication and design approaches, which will be outlined. The initial joint tests did not include mechanical fasteners. Adhesives were utilized at the joint to composite tube interfaces, along with mechanical fasteners during final fabrication (thus creating a stronger joint than the adhesive only variant). In general the prototype was focused on a potential in-space assembly approach, or kit-of-parts construction concept, which would not necessarily require the inclusion of an adhesive in the joint regions. However, given the tie in to legacy Station hardware (and potential flight loads with imbedded hardware mass loadings), the rack was built as stiff and strong as possible. Preliminary torque down tests were also conducted to determine the feasibility of mounting the composite honeycomb panels to the composite tubing sections via the additively manufactured tube inserts. Additional fastener torque down tests were also conducted with inserts (helicoils) imbedded within the joints. Lessons learned are also included and discussed.

The Habitat Demonstration Unit Project: A Modular Instrumentation System for a Deep Space Habitat

NASA Technical Reports Server (NTRS)

Rojdev, Kristina; Kennedy, Kriss J.; Yim, Hester; Williamsn, Robert M.; Hafermalz, Scott; Wagner, Raymond S.

2011-01-01

NASA is focused on developing human exploration capabilities in low Earth orbit (LEO), expanding to near Earth asteroids (NEA), and finally to Mars. Habitation is a crucial aspect of human exploration, and a current focus of NASA activities. The Habitation Demonstration Unit (HDU) is a project focused on developing an autonomous habitation system that enables human exploration of space by providing engineers and scientists with a test bed to develop, integrate, test, and evaluate habitation systems. A critical feature of the HDU is the instrumentation system, which monitors key subsystems within the habitat. The following paper will discuss the HDU instrumentation system performance and lessons learned during the 2010 Desert Research and Technology Studies (D-RaTS). In addition, this paper will discuss the evolution of the instrumentation system to support the 2011 Deep Space Habitat configuration, the challenges, and the lessons learned of implementing this configuration. In 2010, the HDU was implemented as a pressurized excursion module (PEM) and was tested at NASA s D-RaTS in Arizona [1]. For this initial configuration, the instrumentation system design used features that were successful in previous habitat instrumentation projects, while also considering challenges, and implementing lessons learned [2]. The main feature of the PEM instrumentation system was the use of a standards-based wireless sensor node (WSN), implementing an IEEE 802.15.4 protocol. Many of the instruments were connected to several WSNs, which wirelessly transmitted data to the command and data handling system via a mesh network. The PEM instrumentation system monitored the HDU during field tests at D-RaTS, and the WSN data was later analyzed to understand the performance of this system. In addition, several lessons learned were gained from the field test experience, which fed into the instrumentation design of the next generation of the HDU.

9 CFR 113.111 - Clostridium Perfringens Type C Toxoid and Bacterin-Toxoid.

Code of Federal Regulations, 2013 CFR

2013-01-01

... a prescribed test shall not be released. (a) Purity test. Final container samples of completed... § 113.26. (b) Safety test. Bulk or final container samples of completed product from each serial shall be tested for safety as provided in § 113.33(b). (c) Potency test. Bulk or final container samples of...

9 CFR 113.111 - Clostridium Perfringens Type C Toxoid and Bacterin-Toxoid.

Code of Federal Regulations, 2014 CFR

2014-01-01

... a prescribed test shall not be released. (a) Purity test. Final container samples of completed... § 113.26. (b) Safety test. Bulk or final container samples of completed product from each serial shall be tested for safety as provided in § 113.33(b). (c) Potency test. Bulk or final container samples of...

9 CFR 113.111 - Clostridium Perfringens Type C Toxoid and Bacterin-Toxoid.

Code of Federal Regulations, 2012 CFR

2012-01-01

... a prescribed test shall not be released. (a) Purity test. Final container samples of completed... § 113.26. (b) Safety test. Bulk or final container samples of completed product from each serial shall be tested for safety as provided in § 113.33(b). (c) Potency test. Bulk or final container samples of...

Pharmacotherapies for decreasing maladaptive choice in drug addiction: Targeting the behavior and the drug.

PubMed

Perkins, Frank N; Freeman, Kevin B

2018-01-01

Drug addiction can be conceptualized as a disorder of maladaptive decision making in which drugs are chosen at the expense of pro-social, nondrug alternatives. The study of decision making in drug addiction has focused largely on the role of impulsivity as a facilitator of addiction, in particular the tendency for drug abusers to choose small, immediate gains over larger but delayed outcomes (i.e., delay discounting). A parallel line of work, also focused on decision making in drug addiction, has focused on identifying the determinants underlying the choice to take drugs over nondrug alternatives (i.e., drug vs. nondrug choice). Both tracks of research have been valuable tools in the development of pharmacotherapies for treating maladaptive decision making in drug addiction, and a number of common drugs have been studied in both designs. However, we have observed that there is little uniformity in the administration regimens of potential treatments between the designs, which hinders congruence in the development of single treatment strategies to reduce both impulsive behavior and drug choice. The current review provides an overview of the drugs that have been tested in both delay-discounting and drug-choice designs, and focuses on drugs that reduced the maladaptive choice in both designs. Suggestions to enhance congruence between the findings in future studies are provided. Finally, we propose the use of a hybridized, experimental approach that may enable researchers to test the effectiveness of therapeutics at decreasing impulsive and drug choice in a single design. Published by Elsevier Inc.

VEG-01: Veggie Hardware Verification Testing

NASA Technical Reports Server (NTRS)

Massa, Gioia; Newsham, Gary; Hummerick, Mary; Morrow, Robert; Wheeler, Raymond

2013-01-01

The Veggie plant/vegetable production system is scheduled to fly on ISS at the end of2013. Since much of the technology associated with Veggie has not been previously tested in microgravity, a hardware validation flight was initiated. This test will allow data to be collected about Veggie hardware functionality on ISS, allow crew interactions to be vetted for future improvements, validate the ability of the hardware to grow and sustain plants, and collect data that will be helpful to future Veggie investigators as they develop their payloads. Additionally, food safety data on the lettuce plants grown will be collected to help support the development of a pathway for the crew to safely consume produce grown on orbit. Significant background research has been performed on the Veggie plant growth system, with early tests focusing on the development of the rooting pillow concept, and the selection of fertilizer, rooting medium and plant species. More recent testing has been conducted to integrate the pillow concept into the Veggie hardware and to ensure that adequate water is provided throughout the growth cycle. Seed sanitation protocols have been established for flight, and hardware sanitation between experiments has been studied. Methods for shipping and storage of rooting pillows and the development of crew procedures and crew training videos for plant activities on-orbit have been established. Science verification testing was conducted and lettuce plants were successfully grown in prototype Veggie hardware, microbial samples were taken, plant were harvested, frozen, stored and later analyzed for microbial growth, nutrients, and A TP levels. An additional verification test, prior to the final payload verification testing, is desired to demonstrate similar growth in the flight hardware and also to test a second set of pillows containing zinnia seeds. Issues with root mat water supply are being resolved, with final testing and flight scheduled for later in 2013.

Stay Focused! The Effects of Internal and External Focus of Attention on Movement Automaticity in Patients with Stroke

PubMed Central

Kal, E. C.; van der Kamp, J.; Houdijk, H.; Groet, E.; van Bennekom, C. A. M.; Scherder, E. J. A.

2015-01-01

Dual-task performance is often impaired after stroke. This may be resolved by enhancing patients’ automaticity of movement. This study sets out to test the constrained action hypothesis, which holds that automaticity of movement is enhanced by triggering an external focus (on movement effects), rather than an internal focus (on movement execution). Thirty-nine individuals with chronic, unilateral stroke performed a one-leg-stepping task with both legs in single- and dual-task conditions. Attentional focus was manipulated with instructions. Motor performance (movement speed), movement automaticity (fluency of movement), and dual-task performance (dual-task costs) were assessed. The effects of focus on movement speed, single- and dual-task movement fluency, and dual-task costs were analysed with generalized estimating equations. Results showed that, overall, single-task performance was unaffected by focus (p = .341). Regarding movement fluency, no main effects of focus were found in single- or dual-task conditions (p’s ≥ .13). However, focus by leg interactions suggested that an external focus reduced movement fluency of the paretic leg compared to an internal focus (single-task conditions: p = .068; dual-task conditions: p = .084). An external focus also tended to result in inferior dual-task performance (β = -2.38, p = .065). Finally, a near-significant interaction (β = 2.36, p = .055) suggested that dual-task performance was more constrained by patients’ attentional capacity in external focus conditions. We conclude that, compared to an internal focus, an external focus did not result in more automated movements in chronic stroke patients. Contrary to expectations, trends were found for enhanced automaticity with an internal focus. These findings might be due to patients’ strong preference to use an internal focus in daily life. Future work needs to establish the more permanent effects of learning with different attentional foci on re-automating motor control after stroke. PMID:26317437

Daylighting Digital Dimmer SBIR Phase 2 Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jones, Morgan

The primary focus of the Phase II Development is the implementation of two key technologies, Task To Wall (TTW) Control, and Wand Gesture light dimming control into an easy to use remote for SSL light control, the MoJo Remote. The MoJo Remote product family includes a battery powered wireless remote, a WiFi gateway as well as Mobile Applications for iOS and Android. Specific accomplishments during the second reporting period include: 1. Finalization and implementation of MoJo Remote Accelerometer and capacitive-touch based UI/UX, referred to as the Wand Gesture UI. 2. Issuance of Patent for Wand Gesture UI. 3. Industrial andmore » Mechanical Design for MoJo Remote and MoJo Gateway. 4. Task To Wall implementation and testing in MoJo Remote. 5. Zooming User Interface (ZUI) for the Mobile App implemented on both iOS and Andriod. 6. iOS Mobile app developed to beta level functionality. 7. Initial Development of the Android Mobile Application. 8. Closed loop color control at task (demonstrated at 2016 SSL R&D Workshop). 9. Task To Wall extended to Color Control, working in simulation. 10. Beta testing begun in Late 2017/Early 2018. The MoJo Remote integrates the Patented TTW Control and the Wand Gesture innovative User Interface, and is currently in Beta testing and on the path to commercialization.« less

Biomass power for rural development. Technical progress report, May 1, 1996--December 31, 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

Neuhauser, E.

Developing commercial energy crops for power generation by the year 2000 is the focus of the DOE/USDA sponsored Biomass Power for Rural Development project. The New York based Salix Consortium project is a multi-partner endeavor, implemented in three stages. Phase-I, Final Design and Project Development, will conclude with the preparation of construction and/or operating permits, feedstock production plans, and contracts ready for signature. Field trials of willow (Salix) have been initiated at several locations in New York (Tully, Lockport, King Ferry, La Facette, Massena, and Himrod) and co-firing tests are underway at Greenidge Station (NYSEG). Phase-II of the project willmore » focus on scale-up of willow crop acreage, construction of co-firing facilities at Dunkirk Station (NMPC), and final modifications for Greenidge Station. There will be testing of the energy crop as part of the gasification trials expected to occur at BED`s McNeill power station and potentially at one of GPU`s facilities. Phase-III will represent full-scale commercialization of the energy crop and power generation on a sustainable basis. Willow has been selected as the energy crop of choice for many reasons. Willow is well suited to the climate of the Northeastern United States, and initial field trials have demonstrated that the yields required for the success of the project are obtainable. Like other energy crops, willow has rural development benefits and could serve to diversify local crop production, provide new sources of income for participating growers, and create new jobs. Willow could be used to put a large base of idle acreage back into crop production. Additionally, the willow coppicing system integrates well with current farm operations and utilizes agricultural practices that are already familiar to farmers.« less

Development of a compact HTS lead unit for the SC correction coils of the SuperKEKB final focusing magnet system

NASA Astrophysics Data System (ADS)

Zong, Zhanguo; Ohuchi, Norihito; Tsuchiya, Kiyosumi; Arimoto, Yasushi

2016-09-01

Forty-three superconducting (SC) correction coils with maximum currents of about 60 A are installed in the SuperKEKB final focusing magnet system. Current leads to energize the SC correction coils should have an affordable heat load and fit the spatial constraints in the service cryostat where the current leads are installed. To address the requirements, design optimization of individual lead was performed with vapor cooled current lead made of a brass material, and a compact unit was designed to accommodate eight current leads together in order to be installed with one port in the service cryostat. The 2nd generation high temperature SC (HTS) tape was adopted and soldered at the cold end of the brass current lead to form a hybrid HTS lead structure. A prototype of the compact lead unit with HTS tape was constructed and tested with liquid helium (LHe) environment. This paper presents a cryogenic measurement system to simulate the real operation conditions in the service cryostat, and analysis of the experimental results. The measured results showed excellent agreement with the theoretical analysis and numerical simulation. In total, 11 sets of the compact HTS lead units were constructed for the 43 SC correction coils at KEK. One set from the mass production was tested in cryogenic conditions, and exhibited the same performance as the prototype. The compact HTS lead unit can feed currents to four SC correction coils simultaneously with the simple requirement of controlling and monitoring helium vapor flow, and has a heat load of about 0.762 L/h in terms of LHe consumption.

A toxicity reduction evaluation for an oily waste treatment plant exhibiting episodic effluent toxicity.

PubMed

Erten-Unal, M; Gelderloos, A B; Hughes, J S

1998-07-30

A Toxicity Reduction Evaluation (TRE) was conducted on the oily wastewater treatment plant (Plant) at a Naval Fuel Depot. The Plant treats ship and ballast wastes, berm water from fuel storage areas and wastes generated in the fuel reclamation plant utilizing physical/chemical treatment processes. In the first period of the project (Period I), the TRE included chemical characterization of the plant wastewaters, monitoring the final effluent for acute toxicity and a thorough evaluation of each treatment process and Plant operating procedures. Toxicity Identification Evaluation (TIE) procedures were performed as part of the overall TRE to characterize and identify possible sources of toxicity. Several difficulties were encountered because the effluent was saline, test organisms were marine species and toxicity was sporadic and unpredictable. The treatability approach utilizing enhancements, improved housekeeping, and operational changes produced substantial reductions in the acute toxicity of the final effluent. In the second period (Period II), additional acute toxicity testing and chemical characterization were performed through the Plant to assess the long-term effects of major unit process improvements for the removal of toxicity. The TIE procedures were also modified for saline wastewaters to focus on suspected class of toxicants such as surfactants. The TRE was successful in reducing acute toxicity of the final effluent through process improvements and operational modifications. The results indicated that the cause of toxicity was most likely due to combination of pollutants (matrix effect) rather than a single pollutant.

The Role of Sentence Position, Allomorph, and Morpheme Type on Accurate Use of s-Related Morphemes by Children Who Are Hard of Hearing

PubMed Central

Koehlinger, Keegan; Oleson, Jacob; McCreery, Ryan; Moeller, Mary Pat

2015-01-01

Purpose Production accuracy of s-related morphemes was examined in 3-year-olds with mild-to-severe hearing loss, focusing on perceptibility, articulation, and input frequency. Method Morphemes with /s/, /z/, and /ɪz/ as allomorphs (plural, possessive, third-person singular –s, and auxiliary and copula “is”) were analyzed from language samples gathered from 51 children (ages: 2;10 [years;months] to 3;8) who are hard of hearing (HH), all of whom used amplification. Articulation was assessed via the Goldman-Fristoe Test of Articulation–Second Edition, and monomorphemic word final /s/ and /z/ production. Hearing was measured via better ear pure tone average, unaided Speech Intelligibility Index, and aided sensation level of speech at 4 kHz. Results Unlike results reported for children with normal hearing, the group of children who are HH correctly produced the /ɪz/ allomorph more than /s/ and /z/ allomorphs. Relative accuracy levels for morphemes and sentence positions paralleled those of children with normal hearing. The 4-kHz sensation level scores (but not the better ear pure tone average or Speech Intelligibility Index), the Goldman-Fristoe Test of Articulation–Second Edition, and word final s/z use all predicted accuracy. Conclusions Both better hearing and higher articulation scores are associated with improved morpheme production, and better aided audibility in the high frequencies and word final production of s/z are particularly critical for morpheme acquisition in children who are HH. PMID:25650750

Nanocoatings for High-Efficiency Industrial and Tooling Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blau, P; Qu, J.; Higdon, C.

This industry-driven project was the result of a successful response by Eaton Corporation to a DOE/ITP Program industry call. It consisted of three phases in which ORNL participated. In addition to Eaton Corporation and ORNL (CRADA), the project team included Ames Laboratory, who developed the underlying concept for aluminum-magnesium-boron based nanocomposite coatings [1], and Greenleaf, a small tooling manufacturer in western Pennsylvania. This report focuses on the portion of this work that was conducted by ORNL in a CRADA with Eaton Corporation. A comprehensive final report for the entire effort, which ended in September 2010, has been prepared by Eatonmore » Corporation. Phase I, “Proof of Concept” ran for one year (September 1, 2006 to September 30, 2007) during which the applicability of AlMgB14 single-phase and nanocomposite coatings on hydraulic material coupons and components as well as on tool inserts was demonstrated.. The coating processes used either plasma laser deposition (PLD) or physical vapor deposition (PVD). During Phase I, ORNL conducted laboratory-scale pin-on-disk and reciprocating pin-on-flat tests of coatings produced by PLD and PVD. Non-coated M2 tool steel was used as a baseline for comparison, and the material for the sliding counterface was Type 52100 bearing steel since it simulated the pump materials. Initial tests were run mainly in a commercial hydraulic fluid named Mobil DTE-24, but some tests were later run in a water-glycol mixture as well. A tribosystem analysis was conducted to define the operating conditions of pump components and to help develop simulative tests in Phase II. Phase II, “Coating Process Scale-up” was intended to use scaled-up process to generate prototype parts. This involved both PLD practices at Ames Lab, and a PVD scale-up study at Eaton using its production capable equipment. There was also a limited scale-up study at Greenleaf for the tooling application. ORNL continued to conduct friction and wear tests on process variants and developed tests to better simulate the applications of interest. ORNL also employed existing lubrication models to better understand hydraulic pump frictional behavior and test results. Phase III, “Functional Testing” focused on finalizing the strategy for commercialization of AlMgB14 coatings for both hydraulic and tooling systems. ORNL continued to provide tribology testing and analysis support for hydraulic pump applications. It included both laboratory-scale coupon testing and the analysis of friction and wear data from full component-level tests performed at Eaton Corp. Laboratory-scale tribology test methods are used to characterize the behavior of nanocomposite coatings prior to running them in full-sized hydraulic pumps. This task also includes developing tribosystems analyses, both to provide a better understanding of the performance of coated surfaces in alternate hydraulic fluids, and to help design useful laboratory protocols. Analysis also includes modeling the lubrication conditions and identifying the physical processes by which wear and friction of the contact interface changes over time. This final report summarizes ORNL’s portion of the nanocomposite coatings development effort and presents both generated data and the analyses that were used in the course of this effort.« less

An adjustable short-focal length, high-gradient PMQ electron-beam final-focus system for the PLEIADES ultra-fast x-ray Thomson source

NASA Astrophysics Data System (ADS)

Lim, Jae-Ku

In the span of a 100 year since the discovery of first x-rays by Roentgen that won him the first Nobel prize in physics, several types of radiation sources have been developed. Currently, radiations at extremely short wavelengths have only been accessed at synchrotron radiation sources. However, the current 3rd generation synchrotron sources can only produce x-rays of energy up to 60 keV and pulse lengths of several picoseconds long. But needs for shorter wavelength and shorter pulse duration radiations demanded by scientists to understand the nature of matter at atomic/molecular scale initiated the new scientific research for the production of sub-picosecond, hard x-rays. At the Lawrence Livermore National Laboratory, a Thomson x-ray source in the backscattering mode---a head-on collision between a high intensity Ti:Sapphire Chirped Pulse Amplification laser and a relativistic electron beam---called the PLEIADES (Picosecond Laser-Electron Inter-Action for the Dynamical Evaluation of Structures) laboratory has been developed. Early works demonstrated the production of quasi-monochromatic, femto-second long, hard x-rays. Initially reported x-ray flux was in the low range of 105--10 6 photons per shot. During the early stage of PLEIADES experiments, 15 T/m electromagnet final focusing quadrupoles (in a triplet lattice configuration) were employed to focus the beam to a 40-50 mum spot-size. A larger focal spot-size beam has a low-density of electron particles available at the interaction with incident photons, which leads to a low scattering probability. The current dissertation shows that by employing a 560 T/m PMQ (Permanent-Magnet Quadrupole) final focus system, an electron beam as small as 10-20 mum can be achieved. The implementation of this final focus system demonstrated the improvement of the total x-ray flux by two orders of magnitude. The PMQ final focus system also produced small electron beams consistently over 30-100 MeV electron beam energy, which enabled the production of x-ray energy over 40-140 keV. In this dissertation, the PLEIADES Thomson x-ray facility will be described in detail includes the 100 MeV linac and the FALCON laser system. Later, we will discuss the design, construction and implementation of the PMQ final focus system in the beamline. The measurement of electron beam parameters before and after the final focus system will be presented. The beam measurements at the interaction region were accomplished with the use of both OTR (Optical Transition Radiation) imaged by a CCD camera and the fast streak camera for respective spatial and temporal alignments. The theoretical analysis in "real beam" effects and spacetime beam jitter effects will be given to help understand the observations. A 3D simulation tool developed for x-ray data analysis was used to provide direct comparisons with the x-ray flux, spectrum distribution and transverse x-ray profile.

Status of DSMT research program

NASA Technical Reports Server (NTRS)

Mcgowan, Paul E.; Javeed, Mehzad; Edighoffer, Harold H.

1991-01-01

The status of the Dynamic Scale Model Technology (DSMT) research program is presented. DSMT is developing scale model technology for large space structures as part of the Control Structure Interaction (CSI) program at NASA Langley Research Center (LaRC). Under DSMT a hybrid-scale structural dynamics model of Space Station Freedom was developed. Space Station Freedom was selected as the focus structure for DSMT since the station represents the first opportunity to obtain flight data on a complex, three-dimensional space structure. Included is an overview of DSMT including the development of the space station scale model and the resulting hardware. Scaling technology was developed for this model to achieve a ground test article which existing test facilities can accommodate while employing realistically scaled hardware. The model was designed and fabricated by the Lockheed Missile and Space Co., and is assembled at LaRc for dynamic testing. Also, results from ground tests and analyses of the various model components are presented along with plans for future subassembly and matted model tests. Finally, utilization of the scale model for enhancing analysis verification of the full-scale space station is also considered.

Heat rejection efficiency research of new energy automobile radiators

NASA Astrophysics Data System (ADS)

Ma, W. S.; Shen, W. X.; Zhang, L. W.

2018-03-01

The driving system of new energy vehicle has larger heat load than conventional engine. How to ensure the heat dissipation performance of the cooling system is the focus of the design of new energy vehicle thermal management system. In this paper, the heat dissipation efficiency of the radiator of the hybrid electric vehicle is taken as the research object, the heat dissipation efficiency of the radiator of the new energy vehicle is studied through the multi-working-condition enthalpy difference test. In this paper, the test method in the current standard QC/T 468-2010 “automobile radiator” is taken, but not limited to the test conditions specified in the standard, 5 types of automobile radiator are chosen, each of them is tested 20 times in simulated condition of different wind speed and engine inlet temperature. Finally, regression analysis is carried out for the test results, and regression equation describing the relationship of radiator heat dissipation heat dissipation efficiency air side flow rate cooling medium velocity and inlet air temperature is obtained, and the influence rule is systematically discussed.

Status of the Correlation Process of the V-HAB Simulation with Ground Tests and ISS Telemetry Data

NASA Technical Reports Server (NTRS)

Ploetner, Peter; Anderson, Molly S.; Czupalla, Markus; Ewert, Micahel K.; Roth, Christof Martin; Zhulov, Anton

2012-01-01

The Virtual Habitat (V-HAB) is a dynamic Life Support System (LSS) simulation, created to investigate future human spaceflight missions. V-HAB provides the capability to optimize LSS during early design phases. Furthermore, it allows simulation of worst case scenarios which cannot be tested in reality. In a nutshell, the tool allows the testing of LSS robustness by means of computer simulations. V-HAB is a modular simulation consisting of a: 1. Closed Environment Module 2. Crew Module 3. Biological Module 4. Physio-Chemical Module The focus of the paper will be the correlation and validation of V-HAB against ground test and flight data. The ECLSS technologies (CDRA, CCAA, OGA, etc.) are correlated one by one against available ground test data, which is briefly described in this paper. The technology models in V-HAB are merged to simulate the ISS ECLSS. This simulation is correlated against telemetry data from the ISS, including the water recovery system and the air revitalization system. Finally, an analysis of the results is included in this paper.

Network Penetration Testing and Research

NASA Technical Reports Server (NTRS)

Murphy, Brandon F.

2013-01-01

This paper will focus the on research and testing done on penetrating a network for security purposes. This research will provide the IT security office new methods of attacks across and against a company's network as well as introduce them to new platforms and software that can be used to better assist with protecting against such attacks. Throughout this paper testing and research has been done on two different Linux based operating systems, for attacking and compromising a Windows based host computer. Backtrack 5 and BlackBuntu (Linux based penetration testing operating systems) are two different "attacker'' computers that will attempt to plant viruses and or NASA USRP - Internship Final Report exploits on a host Windows 7 operating system, as well as try to retrieve information from the host. On each Linux OS (Backtrack 5 and BlackBuntu) there is penetration testing software which provides the necessary tools to create exploits that can compromise a windows system as well as other operating systems. This paper will focus on two main methods of deploying exploits 1 onto a host computer in order to retrieve information from a compromised system. One method of deployment for an exploit that was tested is known as a "social engineering" exploit. This type of method requires interaction from unsuspecting user. With this user interaction, a deployed exploit may allow a malicious user to gain access to the unsuspecting user's computer as well as the network that such computer is connected to. Due to more advance security setting and antivirus protection and detection, this method is easily identified and defended against. The second method of exploit deployment is the method mainly focused upon within this paper. This method required extensive research on the best way to compromise a security enabled protected network. Once a network has been compromised, then any and all devices connected to such network has the potential to be compromised as well. With a compromised network, computers and devices can be penetrated through deployed exploits. This paper will illustrate the research done to test ability to penetrate a network without user interaction, in order to retrieve personal information from a targeted host.

Development of MijnAVL, an Interactive Portal to Empower Breast and Lung Cancer Survivors: An Iterative, Multi-Stakeholder Approach.

PubMed

Kuijpers, Wilma; Groen, Wim G; Oldenburg, Hester Sa; Wouters, Michel Wjm; Aaronson, Neil K; van Harten, Wim H

2015-01-22

MijnAVL (MyAVL) is an interactive portal being developed to empower cancer survivors. Literature review and focus groups yielded the selection of features such as access to the electronic medical record (EMR), patient reported outcomes (PROs) and related feedback, and a physical activity support program. Our aim was to present a final design of MijnAVL based on (1) health professionals' evaluation of proposed features, (2) cancer survivors' evaluation of a first draft, and (3) cancer survivors' evaluation of a functional online prototype. Professionals from various disciplines gave input to the content of and procedures related to MijnAVL. Subsequently, 16 cancer survivors participated in an interview to evaluate content and graphic design of a first draft (shown with screenshots). Finally, 7 survivors participated in a usability test with a fully functional prototype. They performed predefined tasks (eg, logging in, finding a test result, completing a questionnaire) while thinking aloud. Descriptive statistics and simple content analysis were used to analyze the data of both the interviews and the usability tests. Professionals supported access to the EMR (eg, histology reports, lab results, and their letters to general practitioners). They also informed the development of PROs and the physical activity support program. Based on the first draft, survivors selected the preferred graphic design, approved the features and provided suggestions for the content (eg, explanation of medical jargon, more concise texts, notification by emails). Usability tests revealed that it was relatively easy to navigate the website and use the different features. Recommendations included, among others, a frequently asked questions section and the use of hyperlinks between different parts of the website. The development of MijnAVL, an interactive portal to empower breast and lung cancer survivors, was performed iteratively and involved multiple groups of end-users. This approach resulted in a usable and understandable final version. Its effectiveness should be determined in further research.

Development of MijnAVL, an Interactive Portal to Empower Breast and Lung Cancer Survivors: An Iterative, Multi-Stakeholder Approach

PubMed Central

Kuijpers, Wilma; Groen, Wim G; Oldenburg, Hester SA; Wouters, Michel WJM; Aaronson, Neil K

2015-01-01

Background MijnAVL (MyAVL) is an interactive portal being developed to empower cancer survivors. Literature review and focus groups yielded the selection of features such as access to the electronic medical record (EMR), patient reported outcomes (PROs) and related feedback, and a physical activity support program. Objective Our aim was to present a final design of MijnAVL based on (1) health professionals' evaluation of proposed features, (2) cancer survivors’ evaluation of a first draft, and (3) cancer survivors’ evaluation of a functional online prototype. Methods Professionals from various disciplines gave input to the content of and procedures related to MijnAVL. Subsequently, 16 cancer survivors participated in an interview to evaluate content and graphic design of a first draft (shown with screenshots). Finally, 7 survivors participated in a usability test with a fully functional prototype. They performed predefined tasks (eg, logging in, finding a test result, completing a questionnaire) while thinking aloud. Descriptive statistics and simple content analysis were used to analyze the data of both the interviews and the usability tests. Results Professionals supported access to the EMR (eg, histology reports, lab results, and their letters to general practitioners). They also informed the development of PROs and the physical activity support program. Based on the first draft, survivors selected the preferred graphic design, approved the features and provided suggestions for the content (eg, explanation of medical jargon, more concise texts, notification by emails). Usability tests revealed that it was relatively easy to navigate the website and use the different features. Recommendations included, among others, a frequently asked questions section and the use of hyperlinks between different parts of the website. Conclusions The development of MijnAVL, an interactive portal to empower breast and lung cancer survivors, was performed iteratively and involved multiple groups of end-users. This approach resulted in a usable and understandable final version. Its effectiveness should be determined in further research. PMID:25614924

Use of robotics for nondestructive inspection of steel highway bridges and structures : final report.

DOT National Transportation Integrated Search

2005-01-01

This report presents the results of a project to finalize and apply a crawling robotic system for the remote visual inspection of high-mast light poles. The first part of the project focused on finalizing the prototype crawler robot hardware and cont...

On the development of an intrinsic hybrid composite

NASA Astrophysics Data System (ADS)

Kießling, R.; Ihlemann, J.; Riemer, M.; Drossel, W.-G.; Scharf, I.; Lampke, T.; Sharafiev, S.; Pouya, M.; F-X Wagner, M.

2016-03-01

Hybrid parts, which combine low weight with high strength, are moving into the focus of the automotive industry, due to their high potential for usage in the field of crash-relevant structures. In this contribution, the development of an intrinsic hybrid composite is presented, with a focus on the manufacturing process, complex simulations of the material behaviour and material testing. The hybrid composite is made up of a continuous fibre- reinforced plastic (FRP), in which a metallic insert is integrated. The mechanical behaviour of the individual components is characterised. For material modelling, an approach is pointed out that enables modelling at large strains by directly connected rheological elements. The connection between the FRP and the metallic insert is realised by a combination of form fit and adhesive bonds. On the one hand, adhesive bonds are generated within a sol gel process. On the other hand, local form elements of the metallic insert are pressed into the FRP. We show how these form elements are generated during the macroscopic forming process. In addition, the applied sol gel process is explained. Finally, we consider design concepts for a specimen type for high strain testing of the resulting interfaces.

Conventional and alternative matrices for driving under the influence of cannabis: recent progress and remaining challenges.

PubMed

Wille, Sarah M R; Ramírez-Fernandez, Maria Del Mar; Samyn, Nele; De Boeck, Gert

2010-04-01

In the past decade much research concerning the impact of cannabis use on road safety has been conducted. More specifically, studies on effects of cannabis smoking on driving performance, as well as epidemiological studies and cannabis-detection techniques have been published. As a result, several countries have adopted driving under the influence of drugs (DUID) legislations, with varying approaches worldwide. A wide variety of bodily fluids have been utilized to determine the presence of cannabis. Urine and blood are the most widely used matrices for DUID legislations. However, more and more publications focus on the usability of oral fluid testing for this purpose. Each matrix provides different information about time and extent of use and likelihood of impairment. This review will focus on the practical aspects of implying a DUID legislation. The pros and cons of the different biological matrices used for Δ(9)-tetrahydrocannabinol screening and quantification will be discussed. In addition, a literature overview concerning (roadside) cannabinoid detection, as well as laboratory confirmation techniques is given. Finally, we will discuss important issues influencing interpretation of these data, such as oral fluid collection, choice of cut-offs, stability and proficiency testing.

Superboom Caustic Analysis and Measurement Program (SCAMP) Final Report

NASA Technical Reports Server (NTRS)

Page, Juliet; Plotkin, Ken; Hobbs, Chris; Sparrow, Vic; Salamone, Joe; Cowart, Robbie; Elmer, Kevin; Welge, H. Robert; Ladd, John; Maglieri, Domenic;

Coalbed-methane pilots - timing, design, and analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roadifer, R.D.; Moore, T.R.

2009-10-15

Four distinct sequential phases form a recommended process for coalbed-methane (CBM)-prospect assessment: initial screening reconnaissance, pilot testing, and final appraisal. Stepping through these four phases provides a program of progressively ramping work and cost, while creating a series of discrete decision points at which analysis of results and risks can be assessed. While discussing each of these phases in some degree, this paper focuses on the third, the critically important pilot-testing phase. This paper contains roughly 30 specific recommendations and the fundamental rationale behind each recommendation to help ensure that a CBM pilot will fulfill its primary objectives of (1)more » demonstrating whether the subject coal reservoir will desorb and produce consequential gas and (2) gathering the data critical to evaluate and risk the prospect at the next-often most critical-decision point.« less

Design and Error Analysis of a Vehicular AR System with Auto-Harmonization.

PubMed

Foxlin, Eric; Calloway, Thomas; Zhang, Hongsheng

2015-12-01

This paper describes the design, development and testing of an AR system that was developed for aerospace and ground vehicles to meet stringent accuracy and robustness requirements. The system uses an optical see-through HMD, and thus requires extremely low latency, high tracking accuracy and precision alignment and calibration of all subsystems in order to avoid mis-registration and "swim". The paper focuses on the optical/inertial hybrid tracking system and describes novel solutions to the challenges with the optics, algorithms, synchronization, and alignment with the vehicle and HMD systems. Tracker accuracy is presented with simulation results to predict the registration accuracy. A car test is used to create a through-the-eyepiece video demonstrating well-registered augmentations of the road and nearby structures while driving. Finally, a detailed covariance analysis of AR registration error is derived.

Research and implementation of SATA protocol link layer based on FPGA

NASA Astrophysics Data System (ADS)

Liu, Wen-long; Liu, Xue-bin; Qiang, Si-miao; Yan, Peng; Wen, Zhi-gang; Kong, Liang; Liu, Yong-zheng

2018-02-01

In order to solve the problem high-performance real-time, high-speed the image data storage generated by the detector. In this thesis, it choose an suitable portable image storage hard disk of SATA interface, it is relative to the existing storage media. It has a large capacity, high transfer rate, inexpensive, power-down data which is not lost, and many other advantages. This paper focuses on the link layer of the protocol, analysis the implementation process of SATA2.0 protocol, and build state machines. Then analyzes the characteristics resources of Kintex-7 FPGA family, builds state machines according to the agreement, write Verilog implement link layer modules, and run the simulation test. Finally, the test is on the Kintex-7 development board platform. It meets the requirements SATA2.0 protocol basically.

A Review of Sex Differences in Peer Relationship Processes: Potential Trade-offs for the Emotional and Behavioral Development of Girls and Boys

PubMed Central

Rose, Amanda J.; Rudolph, Karen D.

2011-01-01

Theory and research on sex differences in adjustment focus largely on parental, societal, and biological influences. However, it also is important to consider how peers contribute to girls’ and boys’ development. This paper provides a critical review of sex differences in: several peer-relationship processes, including behavioral and social-cognitive styles, stress and coping, and relationship provisions. Based on this review, a speculative peer-socialization model is presented that considers the implications of these sex differences for girls’ and boys’ emotional and behavioral development. Central to this model is the idea that sex-linked relationship processes have costs and benefits for girls’ and boys’ adjustment. Finally, we present recent research testing certain model components and propose approaches for testing understudied aspects of the model. PMID:16435959

A gyrokinetic one-dimensional scrape-off layer model of an edge-localized mode heat pulse

DOE PAGES

Shi, E. L.; Hakim, A. H.; Hammett, G. W.

2015-02-03

An electrostatic gyrokinetic-based model is applied to simulate parallel plasma transport in the scrape-off layer to a divertor plate. We focus on a test problem that has been studied previously, using parameters chosen to model a heat pulse driven by an edge-localized mode in JET. Previous work has used direct particle-in-cellequations with full dynamics, or Vlasov or fluid equations with only parallel dynamics. With the use of the gyrokinetic quasineutrality equation and logical sheathboundary conditions, spatial and temporal resolution requirements are no longer set by the electron Debye length and plasma frequency, respectively. Finally, this test problem also helps illustratemore » some of the physics contained in the Hamiltonian form of the gyrokineticequations and some of the numerical challenges in developing an edge gyrokinetic code.« less

Deformed ellipsoidal diffraction grating blank

NASA Technical Reports Server (NTRS)

Decew, Alan E., Jr.

1994-01-01

The Deformed Ellipsoidal Grating Blank (DEGB) is the primary component in an ultraviolet spectrometer. Since one of the major concerns for these instruments is throughput, significant efforts are made to reduce the number of components and subsequently reflections. Each reflection results in losses through absorption and scattering. It is these two sources of photon loss that dictated the requirements for the DEGB. The first goal is to shape the DEGB in such a way that the energy at the entrance slit is focused as well as possible on the exit slit. The second goal is to produce a surface smooth enough to minimize the photon loss due to scattering. The program was accomplished in three phases. The first phase was the fabrication planning. The second phase was the actual fabrication and initial testing. The last phase was the final testing of the completed DEGB.

PHARAO flight model: optical on ground performance tests

NASA Astrophysics Data System (ADS)

Lévèque, T.; Faure, B.; Esnault, F. X.; Grosjean, O.; Delaroche, C.; Massonnet, D.; Escande, C.; Gasc, Ph.; Ratsimandresy, A.; Béraud, S.; Buffe, F.; Torresi, P.; Larivière, Ph.; Bernard, V.; Bomer, T.; Thomin, S.; Salomon, C.; Abgrall, M.; Rovera, D.; Moric, I.; Laurent, Ph.

2017-11-01

PHARAO (Projet d'Horloge Atomique par Refroidissement d'Atomes en Orbite), which has been developed by CNES, is the first primary frequency standard specially designed for operation in space. PHARAO is the main instrument of the ESA mission ACES (Atomic Clock Ensemble in Space). ACES payload will be installed on-board the International Space Station (ISS) to perform fundamental physics experiments. All the sub-systems of the Flight Model (FM) have now passed the qualification process and the whole FM of the cold cesium clock, PHARAO, is being assembled and will undergo extensive tests. The expected performances in space are frequency accuracy less than 3.10-16 (with a final goal at 10-16) and frequency stability of 10-13 τ-1/2. In this paper, we focus on the laser source performances and the main results on the cold atom manipulation.

Design and application of electromechanical actuators for deep space missions

NASA Technical Reports Server (NTRS)

Haskew, Tim A.; Wander, John

1994-01-01

This progress report documents research and development efforts performed from August 16, 1993 through August 15, 1994 on NASA Grant NAG8-240, 'Design and Application of Electromechanical Actuators for Deep Space Missions.' Since the submission of our last progress report in February 1994, our efforts have been almost entirely focused on final construction of the test stand and experiment design. Hence, this report is dedicated solely to these topics. However, updates on our research personnel and our health monitoring and fault management efforts are provided in this summary. Following this executive summary are two report sections. The first is devoted to the motor drive being constructed for the test stand. The thrust of the next section is the mechanical and hydraulic design and construction based on the planned experimental requirements. Following both major sections are three appendices.

Best practice guidelines for molecular genetic diagnosis of cystic fibrosis and CFTR-related disorders--updated European recommendations.

PubMed

Dequeker, Els; Stuhrmann, Manfred; Morris, Michael A; Casals, Teresa; Castellani, Carlo; Claustres, Mireille; Cuppens, Harry; des Georges, Marie; Ferec, Claude; Macek, Milan; Pignatti, Pier-Franco; Scheffer, Hans; Schwartz, Marianne; Witt, Michal; Schwarz, Martin; Girodon, Emmanuelle

2009-01-01

The increasing number of laboratories offering molecular genetic analysis of the CFTR gene and the growing use of commercial kits strengthen the need for an update of previous best practice guidelines (published in 2000). The importance of organizing regional or national laboratory networks, to provide both primary and comprehensive CFTR mutation screening, is stressed. Current guidelines focus on strategies for dealing with increasingly complex situations of CFTR testing. Diagnostic flow charts now include testing in CFTR-related disorders and in fetal bowel anomalies. Emphasis is also placed on the need to consider ethnic or geographic origins of patients and individuals, on basic principles of risk calculation and on the importance of providing accurate laboratory reports. Finally, classification of CFTR mutations is reviewed, with regard to their relevance to pathogenicity and to genetic counselling.

Studies of beam position monitor stability

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tenenbaum, P.

1998-05-01

The authors present the results from two studies of the time stability between the mechanical center of a beam position monitor and its electrical/electronic center. In the first study, a group of 93 BPM processors was calibrated via Test Pulse Generator once per hour in order to measure the contribution of the readout electronics to offset drifts. In the second study, a triplet of stripline BPMs in the Final Focus Test Beam, separated only by drift spaces, was read out every 6 minutes during 1 week of beam operation. In both cases offset stability was observed to be on themore » order of microns over time spans ranging from hours to days, although during the beam study much worse performance was also observed. Implications for the beam position monitor system of future linear collider systems are discussed.« less

Advances in Large Grain Resonators for the European XFEL

NASA Astrophysics Data System (ADS)

Singer, W.; Aderhold, S.; Iversen, J.; Kreps, G.; Matheisen, A.; Singer, X.; Twarowski, K.; Weise, H.; Pekeler, M.; Scholz, F.; Spaniol, B.; Stiedl, E.

2011-03-01

An overview of the activities within the DESY test program of 1.3 GHz TESLA shape 9-cell Large Grain (LG) resonators for the European XFEL, which have taken place in last 4 years, is presented. Attention is devoted to development of LG disc production and cavity fabrication from this material, focusing in particular on aspects of production at reasonable accuracy and costs. More than 200 LG discs were manufactured, eleven 9-cell resonators produced, partially treated at the company Research Instruments (RI) (former ACCEL) and finally treated and RF tested at DESY. Two of the LG cavities are currently used in the FLASH accelerator operation, which is the best demonstration of the feasibility of the LG application. The program compares large grain material with standard sheet niobium. Some data and perspectives of the LG application are discussed.

Issues and opportunities: beam simulations for heavy ion fusion

DOE Office of Scientific and Technical Information (OSTI.GOV)

Friedman, A

1999-07-15

UCRL- JC- 134975 PREPRINT code offering 3- D, axisymmetric, and ''transverse slice'' (steady flow) geometries, with a hierarchy of models for the ''lattice'' of focusing, bending, and accelerating elements. Interactive and script- driven code steering is afforded through an interpreter interface. The code runs with good parallel scaling on the T3E. Detailed simulations of machine segments and of complete small experiments, as well as simplified full- system runs, have been carried out, partially benchmarking the code. A magnetoinductive model, with module impedance and multi- beam effects, is under study. experiments, including an injector scalable to multi- beam arrays, a high-more » current beam transport and acceleration experiment, and a scaled final- focusing experiment. These ''phase I'' projects are laying the groundwork for the next major step in HIF development, the Integrated Research Experiment (IRE). Simulations aimed directly at the IRE must enable us to: design a facility with maximum power on target at minimal cost; set requirements for hardware tolerances, beam steering, etc.; and evaluate proposed chamber propagation modes. Finally, simulations must enable us to study all issues which arise in the context of a fusion driver, and must facilitate the assessment of driver options. In all of this, maximum advantage must be taken of emerging terascale computer architectures, requiring an aggressive code development effort. An organizing principle should be pursuit of the goal of integrated and detailed source- to- target simulation. methods for analysis of the beam dynamics in the various machine concepts, using moment- based methods for purposes of design, waveform synthesis, steering algorithm synthesis, etc. Three classes of discrete- particle models should be coupled: (1) electrostatic/ magnetoinductive PIC simulations should track the beams from the source through the final- focusing optics, passing details of the time- dependent distribution function to (2) electromagnetic or magnetoinductive PIC or hybrid PIG/ fluid simulations in the fusion chamber (which would finally pass their particle trajectory information to the radiation- hydrodynamics codes used for target design); in parallel, (3) detailed PIC, delta- f, core/ test- particle, and perhaps continuum Vlasov codes should be used to study individual sections of the driver and chamber very carefully; consistency may be assured by linking data from the PIC sequence, and knowledge gained may feed back into that sequence.« less

A Pharmacovigilance Signaling System Based on FDA Regulatory Action and Post-Marketing Adverse Event Reports.

PubMed

Hoffman, Keith B; Dimbil, Mo; Tatonetti, Nicholas P; Kyle, Robert F

2016-06-01

Many serious drug adverse events (AEs) only manifest well after regulatory approval. Therefore, the development of signaling methods to use with post-approval AE databases appears vital to comprehensively assess real-world drug safety. However, with millions of potential drug-AE pairs to analyze, the issue of focus is daunting. Our objective was to develop a signaling platform that focuses on AEs with historically demonstrated regulatory interest and to analyze such AEs with a disproportional reporting method that offers broad signal detection and acceptable false-positive rates. We analyzed over 1500 US FDA regulatory actions (safety communications and drug label changes) from 2008 to 2015 to construct a list of eligible signal AEs. The FDA Adverse Event Reporting System (FAERS) was used to evaluate disproportional reporting rates, constrained by minimum case counts and confidence interval limits, of these selected AEs for 109 training drugs. This step led to 45 AEs that appeared to have a low likelihood of being added to a label by FDA, so they were removed from the signal eligible list. We measured disproportional reporting for the final group of eligible AEs on a test group of 29 drugs that were not used in either the eligible list construction or the training steps. In a group of 29 test drugs, our model reduced the number of potential drug-AE signals from 41,834 to 97 and predicted 73 % of individual drug label changes. The model also predicted at least one AE-drug pair label change in 66 % of all the label changes for the test drugs. By concentrating on AE types with already demonstrated interest to FDA, we constructed a signaling system that provided focus regarding drug-AE pairs and suitable accuracy with regard to the issuance of FDA labeling changes. We suggest that focus on historical regulatory actions may increase the utility of pharmacovigilance signaling systems.

Fundamentals for Team Based Rehearsals and the Differences Between Low Earth and Deep Space Missions

NASA Technical Reports Server (NTRS)

Gomez-Rosa, Carlos; Alfonzo, Agustin; Cifuentes, Juan; Wasiak, Francis

2015-01-01

Presentation to be presented at the 2015 IEEE Aerospace Conference, Big Sky, Montana, March 7-14-2015.Rehearsals are mission level readiness tests that exercise personnel, operational process, and flight products, in a near flight like environment. The program is started 6-9 months prior to launch and is used to ensure the final as built system will meet mission goals (i.e. validation). On Deep Space missions you rehearse cruise activities post launch!Focus on critical activities to the mission, (i.e. propulsive maneuvers, instrument commissioning and any first time events or coordinating activities that involve major stakeholders).

A 200 Watt Traveling Wave-Tube for the Communications Technology Satellite

NASA Technical Reports Server (NTRS)

Jones, C. L.

1976-01-01

This final report presents the results of the design, development, and test of experimental and production units of a PPM focused traveling wave tube (L-5394) that produces 225 watts of CW RF power over 85 MHz centered at 12.080 GHz. The tube uses a coupled cavity RF circuit with a velocity taper for greater than 26 percent basic efficiency. Overall efficiency of 50 percent is achieved by the incorporation of a multistage depressed collector designed at NASA Lewis Research Center. The collector is cooled by direct radiation to deep space. The tube was designed to be used for broadcasting power transmission from a satellite.

Characterization of BOR-60 Irradiated 14YWT-NFA1 Tubes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Saleh, Tarik A.; Maloy, Stuart Andrew; Aydogan, Eda

2017-02-15

Tubes of FCRD 14YWT-NFA1 Alloy were placed in the BOR-60 reactor and irradiated under a fast flux neutron environment to two conditions: 7 dpa at 360-370 °C and 6 dpa at 385-430 °C. Small sections of the tube were cut and sent to UC Berkeley for nanohardness testing and focused ion beam (FIB) milling of TEM specimens. FIB specimens were sent back to LANL for final FIB milling and TEM imaging. Hardness data and TEM images are presented in this report. This is the first fast reactor neutron irradiated information on the 14YWT-NFA1 alloy.

Tension between the theoretical thinking and the empirical method: is it an inevitable fate for psychology?

PubMed

Omi, Yasuhiro

2012-03-01

This paper will start from focusing on the limitations of quantitative approach in psychology from three viewpoints. First--data collection, especially experiments and questionnaires as two major methods of quantitative approach. The second limitation is data aggregation, followed by the third--statistical significance testing. After that, recent spread of qualitative approach as another option for one of psychological methods will be introduced and a controversy surrounding epistemology of qualitative approach will be also introduced. Finally, it will be discussed that accumulation of faithful descriptions on reality, especially from qualitative approach, would be needed for producing creative research.

Short-term cropland responses to temperature extreme events during late winter

NASA Astrophysics Data System (ADS)

De Simon, G.; Alberti, G.; Delle Vedove, G.; Peressotti, A.; Zaldei, A.; Miglietta, F.

2013-04-01

In recent years, several studies have focused on terrestrial ecosystem response to extreme events. Most of this research has been conducted in natural ecosystems, but few have considered agro-ecosystems. In this study, we investigated the impact of a manipulated warmer or cooler late winter-early spring on the carbon budget and final harvest of a soybean crop (Glycine max (L.) Merr.). Soil temperature was altered by manipulating soil albedo by covering the soil surface with a layer of inert silica gravel. We tested three treatments: cooling (Co), warming (W), mix (M) and control (C). An automated system continuously measured soil heterotrophic respiration (Rh), soil temperature profiles, and soil water content across the entire year in each plot. Phenological phases were periodically assessed and final harvest was measured in each plot. Results showed that treatments had only a transient effect on daily Rh rates which did not result in a total annual carbon budget significantly different from control, even though cooling showed a significant reduction in final harvest. We also observed anticipation in seed germination in both W and M treatments and a delay in germination for Co. Moreover, plant density and growth increased in W and M and decreased in Co.

Evaluation of fertilizer-drawn forward osmosis for sustainable agriculture and water reuse in arid regions.

PubMed

Chekli, Laura; Kim, Youngjin; Phuntsho, Sherub; Li, Sheng; Ghaffour, Noreddine; Leiknes, TorOve; Shon, Ho Kyong

2017-02-01

The present study focused on the performance of the FDFO process to achieve simultaneous water reuse from wastewater and production of nutrient solution for hydroponic application. Bio-methane potential (BMP) measurements were firstly carried out to determine the effect of osmotic concentration of wastewater achieved in the FDFO process on the anaerobic activity. Results showed that 95% water recovery from the FDFO process is the optimum value for further AnMBR treatment. Nine different fertilizers were then tested based on their FO performance (i.e. water flux, water recovery and reverse salt flux) and final nutrient concentration. From this initial screening, ammonium phosphate monobasic (MAP), ammonium sulfate (SOA) and mono-potassium phosphate were selected for long term experiments to investigate the maximum water recovery achievable. After the experiments, hydraulic membrane cleaning was performed to assess the water flux recovery. SOA showed the highest water recovery rate, up to 76% while KH 2 PO 4 showed the highest water flux recovery, up to 75% and finally MAP showed the lowest final nutrient concentration. However, substantial dilution was still necessary to comply with the standards for fertigation even if the recovery rate was increased. Copyright © 2016 Elsevier Ltd. All rights reserved.

Out-of-Focus Projector Calibration Method with Distortion Correction on the Projection Plane in the Structured Light Three-Dimensional Measurement System.

PubMed

Zhang, Jiarui; Zhang, Yingjie; Chen, Bo

2017-12-20

The three-dimensional measurement system with a binary defocusing technique is widely applied in diverse fields. The measurement accuracy is mainly determined by out-of-focus projector calibration accuracy. In this paper, a high-precision out-of-focus projector calibration method that is based on distortion correction on the projection plane and nonlinear optimization algorithm is proposed. To this end, the paper experimentally presents the principle that the projector has noticeable distortions outside its focus plane. In terms of this principle, the proposed method uses a high-order radial and tangential lens distortion representation on the projection plane to correct the calibration residuals caused by projection distortion. The final accuracy parameters of out-of-focus projector were obtained using a nonlinear optimization algorithm with good initial values, which were provided by coarsely calibrating the parameters of the out-of-focus projector on the focal and projection planes. Finally, the experimental results demonstrated that the proposed method can accuracy calibrate an out-of-focus projector, regardless of the amount of defocusing.

The effect of user's perceived presence and promotion focus on usability for interacting in virtual environments.

PubMed

Sun, Huey-Min; Li, Shang-Phone; Zhu, Yu-Qian; Hsiao, Bo

2015-09-01

Technological advance in human-computer interaction has attracted increasing research attention, especially in the field of virtual reality (VR). Prior research has focused on examining the effects of VR on various outcomes, for example, learning and health. However, which factors affect the final outcomes? That is, what kind of VR system design will achieve higher usability? This question remains largely. Furthermore, when we look at VR system deployment from a human-computer interaction (HCI) lens, does user's attitude play a role in achieving the final outcome? This study aims to understand the effect of immersion and involvement, as well as users' regulatory focus on usability for a somatosensory VR learning system. This study hypothesized that regulatory focus and presence can effectively enhance user's perceived usability. Survey data from 78 students in Taiwan indicated that promotion focus is positively related to user's perceived efficiency, whereas involvement and promotion focus are positively related to user's perceived effectiveness. Promotion focus also predicts user satisfaction and overall usability perception. Copyright © 2015 Elsevier Ltd and The Ergonomics Society. All rights reserved.

Letter to the editor concerning the article "Performance of gymnastics skill benefits from an external focus of attention" by Abdollahipour, Wulf, Psotta & Nieto (2015).

PubMed

Collins, Dave; Carson, Howie J; Toner, John

2016-01-01

Abdollahipour, Wulf, Psotta, and Nieto (2015) recently published data in the Journal of Sports Sciences to show that an external focus of attention promotes superior performance effects (gymnastics jump height and judged movement form score) when compared to internal or control foci during skill execution without an implement involved. While we do not contest the veracity of findings reported, nor others that have been used to support beneficial effects of an external focus of attention, in this Letter to the Editor we comment on considerable methodological limitations associated with this and previous studies that, we suggest, have resulted in serious theoretical oversights regarding the control of movement and, most crucially from our practitioner perspective, suboptimal recommendations for applied coaching practice. Specifically, we discuss the lack of consideration towards translational research in this area, the problematic nature of attentional focus cues employed, interpretation of findings in relation to other applied recommendations and coherence with mechanistic underpinning and, finally, the representative nature of task involved. In summary, while (laboratory) research evidence may appear to be conclusive, we suggest that the focus of attention effects are in need of more ecologically valid and rigorous testing as well as consideration of current coaching practices if it is to optimally serve the applied sporting domain that it purportedly aims to.

Retrieval Practice and Spacing Effects in Young and Older Adults: An Examination of the Benefits of Desirable Difficulty

PubMed Central

Maddox, Geoffrey B.; Balota, David A.

2015-01-01

The present study examined how the function relating continued retrieval practice (e.g., 1, 3, or 5 tests) and long-term memory retention is modulated by desirable difficulty (Bjork, 1994). Of particular interest was how retrieval difficulty differed across young and older adults and across manipulations of lag (Experiment 1) and spacing (Experiment 2). To extend on previous studies, acquisition phase response latency was used as a proxy for retrieval difficulty, and analysis of final test performance was conditionalized on acquisition phase retrieval success to more directly examine the influence of desirable difficulty on retention. Results from Experiment 1 revealed that continued testing in the short lag condition led to consistent increases in retention, whereas continued testing in the long lag condition led to increasingly smaller benefits in retention for both age groups. Results from Experiment 2 revealed that repeated spaced testing enhanced retention relative to taking one spaced test for both age groups; however, repeated massed testing only enhanced retention over taking one test for young adults. Across both experiments, the response latency results were overall consistent with an influence of desirable difficulty on retention. Discussion focuses on the role of desirable difficulty during encoding in producing the benefits of lag, spacing, and testing. PMID:25616776

An adaptable, low cost test-bed for unmanned vehicle systems research

NASA Astrophysics Data System (ADS)

Goppert, James M.

2011-12-01

An unmanned vehicle systems test-bed has been developed. The test-bed has been designed to accommodate hardware changes and various vehicle types and algorithms. The creation of this test-bed allows research teams to focus on algorithm development and employ a common well-tested experimental framework. The ArduPilotOne autopilot was developed to provide the necessary level of abstraction for multiple vehicle types. The autopilot was also designed to be highly integrated with the Mavlink protocol for Micro Air Vehicle (MAV) communication. Mavlink is the native protocol for QGroundControl, a MAV ground control program. Features were added to QGroundControl to accommodate outdoor usage. Next, the Mavsim toolbox was developed for Scicoslab to allow hardware-in-the-loop testing, control design and analysis, and estimation algorithm testing and verification. In order to obtain linear models of aircraft dynamics, the JSBSim flight dynamics engine was extended to use a probabilistic Nelder-Mead simplex method. The JSBSim aircraft dynamics were compared with wind-tunnel data collected. Finally, a structured methodology for successive loop closure control design is proposed. This methodology is demonstrated along with the rest of the test-bed tools on a quadrotor, a fixed wing RC plane, and a ground vehicle. Test results for the ground vehicle are presented.

Laser damage metrology in biaxial nonlinear crystals using different test beams

NASA Astrophysics Data System (ADS)

Hildenbrand, Anne; Wagner, Frank R.; Akhouayri, Hassan; Natoli, Jean-Yves; Commandre, Mireille

2008-01-01

Laser damage measurements in nonlinear optical crystals, in particular in biaxial crystals, may be influenced by several effects proper to these materials or greatly enhanced in these materials. Before discussion of these effects, we address the topic of error bar determination for probability measurements. Error bars for the damage probabilities are important because nonlinear crystals are often small and expensive, thus only few sites are used for a single damage probability measurement. We present the mathematical basics and a flow diagram for the numerical calculation of error bars for probability measurements that correspond to a chosen confidence level. Effects that possibly modify the maximum intensity in a biaxial nonlinear crystal are: focusing aberration, walk-off and self-focusing. Depending on focusing conditions, propagation direction, polarization of the light and the position of the focus point in the crystal, strong aberrations may change the beam profile and drastically decrease the maximum intensity in the crystal. A correction factor for this effect is proposed, but quantitative corrections are not possible without taking into account the experimental beam profile after the focusing lens. The characteristics of walk-off and self-focusing have quickly been reviewed for the sake of completeness of this article. Finally, parasitic second harmonic generation may influence the laser damage behavior of crystals. The important point for laser damage measurements is that the amount of externally observed SHG after the crystal does not correspond to the maximum amount of second harmonic light inside the crystal.

Utility of an Abbreviated Dizziness Questionnaire to Differentiate between Causes of Vertigo and Guide Appropriate Referral: A Multicenter Prospective Blinded Study

PubMed Central

Roland, Lauren T.; Kallogjeri, Dorina; Sinks, Belinda C.; Rauch, Steven D.; Shepard, Neil T.; White, Judith A.; Goebel, Joel A.

2015-01-01

Objective Test performance of a focused dizziness questionnaire’s ability to discriminate between peripheral and non-peripheral causes of vertigo. Study Design Prospective multi-center Setting Four academic centers with experienced balance specialists Patients New dizzy patients Interventions A 32-question survey was given to participants. Balance specialists were blinded and a diagnosis was established for all participating patients within 6 months. Main outcomes Multinomial logistic regression was used to evaluate questionnaire performance in predicting final diagnosis and differentiating between peripheral and non-peripheral vertigo. Univariate and multivariable stepwise logistic regression were used to identify questions as significant predictors of the ultimate diagnosis. C-index was used to evaluate performance and discriminative power of the multivariable models. Results 437 patients participated in the study. Eight participants without confirmed diagnoses were excluded and 429 were included in the analysis. Multinomial regression revealed that the model had good overall predictive accuracy of 78.5% for the final diagnosis and 75.5% for differentiating between peripheral and non-peripheral vertigo. Univariate logistic regression identified significant predictors of three main categories of vertigo: peripheral, central and other. Predictors were entered into forward stepwise multivariable logistic regression. The discriminative power of the final models for peripheral, central and other causes were considered good as measured by c-indices of 0.75, 0.7 and 0.78, respectively. Conclusions This multicenter study demonstrates a focused dizziness questionnaire can accurately predict diagnosis for patients with chronic/relapsing dizziness referred to outpatient clinics. Additionally, this survey has significant capability to differentiate peripheral from non-peripheral causes of vertigo and may, in the future, serve as a screening tool for specialty referral. Clinical utility of this questionnaire to guide specialty referral is discussed. PMID:26485598

Utility of an Abbreviated Dizziness Questionnaire to Differentiate Between Causes of Vertigo and Guide Appropriate Referral: A Multicenter Prospective Blinded Study.

PubMed

Roland, Lauren T; Kallogjeri, Dorina; Sinks, Belinda C; Rauch, Steven D; Shepard, Neil T; White, Judith A; Goebel, Joel A

2015-12-01

Test performance of a focused dizziness questionnaire's ability to discriminate between peripheral and nonperipheral causes of vertigo. Prospective multicenter. Four academic centers with experienced balance specialists. New dizzy patients. A 32-question survey was given to participants. Balance specialists were blinded and a diagnosis was established for all participating patients within 6 months. Multinomial logistic regression was used to evaluate questionnaire performance in predicting final diagnosis and differentiating between peripheral and nonperipheral vertigo. Univariate and multivariable stepwise logistic regression were used to identify questions as significant predictors of the ultimate diagnosis. C-index was used to evaluate performance and discriminative power of the multivariable models. In total, 437 patients participated in the study. Eight participants without confirmed diagnoses were excluded and 429 were included in the analysis. Multinomial regression revealed that the model had good overall predictive accuracy of 78.5% for the final diagnosis and 75.5% for differentiating between peripheral and nonperipheral vertigo. Univariate logistic regression identified significant predictors of three main categories of vertigo: peripheral, central, and other. Predictors were entered into forward stepwise multivariable logistic regression. The discriminative power of the final models for peripheral, central, and other causes was considered good as measured by c-indices of 0.75, 0.7, and 0.78, respectively. This multicenter study demonstrates a focused dizziness questionnaire can accurately predict diagnosis for patients with chronic/relapsing dizziness referred to outpatient clinics. Additionally, this survey has significant capability to differentiate peripheral from nonperipheral causes of vertigo and may, in the future, serve as a screening tool for specialty referral. Clinical utility of this questionnaire to guide specialty referral is discussed.

V-SUIT Model Validation Using PLSS 1.0 Test Results

NASA Technical Reports Server (NTRS)

Olthoff, Claas

2015-01-01

The dynamic portable life support system (PLSS) simulation software Virtual Space Suit (V-SUIT) has been under development at the Technische Universitat Munchen since 2011 as a spin-off from the Virtual Habitat (V-HAB) project. The MATLAB(trademark)-based V-SUIT simulates space suit portable life support systems and their interaction with a detailed and also dynamic human model, as well as the dynamic external environment of a space suit moving on a planetary surface. To demonstrate the feasibility of a large, system level simulation like V-SUIT, a model of NASA's PLSS 1.0 prototype was created. This prototype was run through an extensive series of tests in 2011. Since the test setup was heavily instrumented, it produced a wealth of data making it ideal for model validation. The implemented model includes all components of the PLSS in both the ventilation and thermal loops. The major components are modeled in greater detail, while smaller and ancillary components are low fidelity black box models. The major components include the Rapid Cycle Amine (RCA) CO2 removal system, the Primary and Secondary Oxygen Assembly (POS/SOA), the Pressure Garment System Volume Simulator (PGSVS), the Human Metabolic Simulator (HMS), the heat exchanger between the ventilation and thermal loops, the Space Suit Water Membrane Evaporator (SWME) and finally the Liquid Cooling Garment Simulator (LCGS). Using the created model, dynamic simulations were performed using same test points also used during PLSS 1.0 testing. The results of the simulation were then compared to the test data with special focus on absolute values during the steady state phases and dynamic behavior during the transition between test points. Quantified simulation results are presented that demonstrate which areas of the V-SUIT model are in need of further refinement and those that are sufficiently close to the test results. Finally, lessons learned from the modelling and validation process are given in combination with implications for the future development of other PLSS models in V-SUIT.

Experience, knowledge, and opinions about childhood genetic testing in Batten disease.

PubMed

Adams, Heather R; Rose, Katherine; Augustine, Erika F; Kwon, Jennifer M; deBlieck, Elisabeth A; Marshall, Frederick J; Vierhile, Amy; Mink, Jonathan W; Nance, Martha A

2014-02-01

Policies for genetic testing in children (GTIC) focus on medical or psychosocial benefit to the child, discouraging or prohibiting carrier testing, and advising caution regarding pre-symptomatic diagnosis if no treatment exists. This study sought to understand parents' perspectives on these issues and determine their experiences and knowledge related to genetic testing for Batten disease - a set of inherited neurodegenerative diseases of childhood onset for which no disease modifying therapies yet exist. Parents of children with Batten disease completed a survey of their knowledge of genetics, experience with genetic testing, and opinions regarding GTIC. 54% had sought genetic testing for non-affected family members, including predictive diagnosis of healthy, at-risk children. Participation in any genetic counseling was associated with greater knowledge on questions about genetics. The majority of parents felt it was better to know ahead of time that a child would develop Batten disease, believed that this knowledge would not alter how they related to their child, and that parents should have the final say in deciding whether to obtain GTIC. Parents of children with an inherited disease are knowledgeable about genetics and wish to establish predictive or carrier status of at-risk children. Copyright © 2013 Elsevier Inc. All rights reserved.

1977 National Debate Tournament Final Debate

ERIC Educational Resources Information Center

Rives, Stanley G., ed.; Boaz, John K., ed.

1977-01-01

Presents a transcript of the final debate of the Thirty-First National Debate Tournament sponsored by the American Forensic Association in 1977. Focuses on the necessity and desirability of requiring airbags to promote automobile safety. (MH)

Direct-writing lithography using laser diode beam focused with single elliptical microlens

NASA Astrophysics Data System (ADS)

Hasan, Md. Nazmul; Haque, Muttahid-Ull; Trisno, Jonathan; Lee, Yung-Chun

2015-10-01

A lithography method is proposed for arbitrary patterning using an elliptically diverging laser diode beam focused with a single planoconvex elliptical microlens. Simulations are performed to model the propagation properties of the laser beam and to design the elliptical microlens, which has two different profiles in the x- and y-axis directions. The microlens is fabricated using an excimer laser dragging method and is then attached to the laser diode using double-sided optically cleared adhesive (OCA) tape. Notably, the use of OCA tape removes the need for a complicated alignment procedure and thus significantly reduces the assembly cost. The minimum focused spot of the laser diode beam is investigated by performing single-shot exposure tests on a photoresist (PR) layer. Finally, the practical feasibility of this lithography technique to generate an arbitrary pattern is demonstrated by dotted and continuous features through thin chromium layer deposition on PR and a metal lift-off process. The results show that the minimum feature size for the dotted patterns is around 6.23 μm, while the minimum linewidths for continuous patterns is 6.44 μm. In other words, the proposed focusing technique has significant potential for writing any arbitrary high-resolution pattern for applications like printed circuit board fabrication.

Feasibility Study for Low Drag Acoustic Liners Final Report

NASA Technical Reports Server (NTRS)

Riedel, Brian; Wu, Jackie

2017-01-01

This report documents the design and structural analysis as a final deliverable for the Phase 1 contract activity. Also included is a community noise test plan, which is a key deliverable for Phase 2. Finally, a high-level estimate (Phase 3 deliverable) is provided for the work statement of Phases 2-4, which covers the build of two inlet test articles, planning and execution of a flight test with the test inlets, as well as data analysis and final documentation. The two test inlets will be compared to the production baseline inlet configuration. There is also a plan to test one of the inlets "hardwalled" using speed tape or some other similar tape to block the acoustic perforations.

A preliminary assessment of the fifth-year chiropractic students' knowledge of anatomy.

PubMed

Strkalj, Goran; Schroder, Tania; Pather, Nalini; Solyali, Veli

2011-01-01

Anatomy has been at the foundation of medical students' training. In recent decades, medical programs in many countries have undergone major reform in both pedagogy and content. These reforms generated intense debates, focusing mainly on the way the new programs affected medical graduates' knowledge of anatomy and their clinical capabilities. Anatomy, however, is not only core to medicine, but also to a number of allied and complementary health disciplines. While the evaluation of anatomy teaching and learning in the medical programs has been heavily scrutinized, anatomy education in the complementary and alternative medicine (CAM) professions, including those, such as chiropractic, in which anatomy has traditionally been one of the main preclinical subjects, has been less frequently evaluated. The study aimed to make a preliminary assessment of the final year chiropractic students' knowledge of anatomy using the "carpal bone test." The testing was conducted on the final-year chiropractic students at Macquarie University in 2009. In this test, the students were given 5 minutes to label an illustration of the bony skeleton of the carpal region. The results of this assessment were then compared to results of previously published surveys using the "carpal bone test." A total of 84 students participated in the study. Thirty-eight percent (38%) of students identified all eight bones, while 60% of students identified five or more carpal bones. The most frequent correctly identified bone was the pisiform, followed by the scaphoid bone (82% and 74% of students, respectively). The trapezium and trapezoid bones were least frequently identified: both by 52% of students each. These results were generally better than those of the previously tested final-year medical students. The importance of anatomy in chiropractors' education has been generally acknowledged. This study suggests that the comparatively high number of hours devoted to anatomy in Macquarie University chiropractic curriculum and underpinning of clinical skills to anatomy knowledge in the senior year have increased retention of anatomy knowledge. The study, preliminary in nature, has also recognized the need for more detailed assessment of teaching and learning of the basic medical sciences in chiropractic and other CAM disciplines.

Mississippi Department of Transportation research peer exchange : final report.

DOT National Transportation Integrated Search

1998-06-01

Peer Exchange Focus Areas : The MDOT Research Division developed focus areas for the exchange as follows: : Maintaining Adequate Resources for Research Activities : Implementation of Research Results : Outreach to Transportation Partners ...

Examination of a pre-exercise, high energy supplement on exercise performance

PubMed Central

Hoffman, Jay R; Kang, Jie; Ratamess, Nicholas A; Hoffman, Mattan W; Tranchina, Christopher P; Faigenbaum, Avery D

2009-01-01

Background The purpose of this study was to examine the effect of a pre-exercise high energy drink on reaction time and anaerobic power in competitive strength/power athletes. In addition, the effect of the pre-exercise drink on subjective feelings of energy, fatigue, alertness and focus was also explored. Methods Twelve male strength/power athletes (21.1 ± 1.3 y; 179.8 ± 7.1 cm; 88.6 ± 12.1 kg; 17.6 ± 3.3% body fat) underwent two testing sessions administered in a randomized and double-blind fashion. During each session, subjects reported to the Human Performance Laboratory and were provided with either 120 ml of a high energy drink (SUP), commercially marketed as Redline Extreme® or 120 ml of a placebo (PL) that was similar in taste and appearance but contained no active ingredients. Following consumption of the supplement or placebo subjects rested quietly for 10-minutes prior to completing a survey and commencing exercise. The survey consisted of 4 questions asking each subject to describe their feelings of energy, fatigue, alertness and focus for that moment. Following the completion of the questionnaire subjects performed a 2-minute quickness and reaction test on the Makoto testing device (Makoto USA, Centennial CO) and a 20-second Wingate Anaerobic Power test. Following a 10-minute rest subjects repeated the testing sequence and after a similar rest period a third and final testing sequence was performed. The Makoto testing device consisted of subjects reacting to both a visual and auditory stimulus and striking one out of 30 potential targets on three towers. Results Significant difference in reaction performance was seen between SUP and PL in both average number of targets struck (55.8 ± 7.4 versus 51.9 ± 7.4, respectively) and percent of targets struck (71.9 ± 10.5% versus 66.8 ± 10.9%, respectively). No significant differences between trials were seen in any anaerobic power measure. Subjective feelings of energy (3.5 ± 0.5 versus 3.1 ± 0.5) and focus (3.8 ± 0.5 versus 3.3 ± 0.7) were significantly higher during SUP compared to PL, respectively. In addition, a trend towards an increase in average alertness (p = 0.06) was seen in SUP compared to P. Conclusion Results indicate a significant increase in reaction performance, with no effect on anaerobic power performance. In addition, ingestion of this supplement significantly improves subjective feelings of focus and energy in male strength/power athletes. PMID:19126213

Testing of advanced technique for linear lattice and closed orbit correction by modeling its application for iota ring at Fermilab

DOE Office of Scientific and Technical Information (OSTI.GOV)

Romanov, A.

Many modern and most future accelerators rely on precise configuration of lattice and trajectory. The Integrable Optics Test Accelerator (IOTA) at Fermilab that is coming to final stages of construction will be used to test advanced approaches of control over particles dynamics. Various experiments planned at IOTA require high flexibility of lattice configuration as well as high precision of lattice and closed orbit control. Dense element placement does not allow to have ideal configuration of diagnostics and correctors for all planned experiments. To overcome this limitations advanced method of lattice an beneficial for other machines. Developed algorithm is based onmore » LOCO approach, extended with various sets of other experimental data, such as dispersion, BPM BPM phase advances, beam shape information from synchrotron light monitors, responses of closed orbit bumps to variations of focusing elements and other. Extensive modeling of corrections for a big number of random seed errors is used to illustrate benefits from developed approach.« less

Exhaust emissions from light- and heavy-duty vehicles: chemical composition, impact of exhaust after treatment, and fuel parameters.

PubMed Central

Westerholm, R; Egebäck, K E

1994-01-01

This paper presents results from the characterization of vehicle exhaust that were obtained primarily within the Swedish Urban Air Project, "Tätortsprojektet." Exhaust emissions from both gasoline- and diesel-fueled vehicles have been investigated with respect to regulated pollutants (carbon monoxide [CO], hydrocarbon [HC], nitrogen oxides [NOx], and particulate), unregulated pollutants, and in bioassay tests (Ames test, TCDD receptor affinity tests). Unregulated pollutants present in both the particle- and the semi-volatile phases were characterized. Special interest was focused on the impact of fuel composition on heavy-duty diesel vehicle emissions. It was confirmed that there exists a quantifiable relationship between diesel-fuel variables of the fuel blends, the chemical composition of the emissions, and their biological effects. According to the results from the multivariate analysis, the most important fuel parameters are: polycyclic aromatic hydrocarbons (PAH) content, 90% distillation point, final boiling point, specific heat, aromatic content, density, and sulfur content. PMID:7529699

User-centered development of a smart phone mobile application delivering personalized real-time advice on sun protection.

PubMed

Buller, David B; Berwick, Marianne; Shane, James; Kane, Ilima; Lantz, Kathleen; Buller, Mary Klein

2013-09-01

Smart phones are changing health communication for Americans. User-centered production of a mobile application for sun protection is reported. Focus groups (n = 16 adults) provided input on the mobile application concept. Four rounds of usability testing were conducted with 22 adults to develop the interface. An iterative programming procedure moved from a specification document to the final mobile application, named Solar Cell. Adults desired a variety of sun protection advice, identified few barriers to use and were willing to input personal data. The Solar Cell prototype was improved from round 1 (seven of 12 tasks completed) to round 2 (11 of 12 task completed) of usability testing and was interoperable across handsets and networks. The fully produced version was revised during testing. Adults rated Solar Cell as highly user friendly (mean = 5.06). The user-centered process produced a mobile application that should help many adults manage sun safety.

Characteristics of quantitative nursing research from 1990 to 2010.

PubMed

Yarcheski, Adela; Mahon, Noreen E

2013-12-01

To assess author credentials of quantitative research in nursing, the composition of the research teams, and the disciplinary focus of the theories tested. Nursing Research, Western Journal of Nursing Research, and Journal of Advanced Nursing were selected for this descriptive study; 1990, 1995, 2000, 2005, and 2010 were included. The final sample consisted of 484 quantitative research articles. From 1990 to 2010, there was an increase in first authors holding doctoral degrees, research from other countries, and funding. Solo authorship decreased; multi-authorship and multidisciplinary teams increased. Theories tested were mostly from psychology; the testing of nursing theory was modest. Multidisciplinary research far outdistanced interdisciplinary research. Quantitative nursing research can be characterized as multidisciplinary (distinct theories from different disciplines) rather than discipline-specific to nursing. Interdisciplinary (theories synthesized from different disciplines) research has been conducted minimally. This study provides information about the growth of the scientific knowledge base of nursing, which has implications for practice. © 2013 Sigma Theta Tau International.

Lifetime Estimation of a Time Projection Chamber X-ray Polarimeter

NASA Technical Reports Server (NTRS)

Hill, Joanne E.; Black, J. Kevin; Brieda, Lubos; Dickens, Patsy L.; deGarcia, Kristina Montt; Hawk, Douglas L.; Hayato, Asami; Jahoda, Keith; Mohammed, Jelila

2013-01-01

The Gravity and Extreme Magnetism Small Explorer (GEMS) X-ray polarimeter Instrument (XPI) was designed to measure the polarization of 23 sources over the course of its 9 month mission. The XPI design consists of two telescopes each with a polarimeter assembly at the focus of a grazing incidence mirror. To make sensitive polarization measurements the GEMS Polarimeter Assembly (PA) employed a gas detection system based on a Time Projection Chamber (TPC) technique. Gas detectors are inherently at risk of degraded performance arising from contamination from outgassing of internal detector components or due to loss of gas. This paper describes the design and the materials used to build a prototype of the flight polarimeter with the required GEMS lifetime. We report the results from outgassing measurements of the polarimeter subassemblies and assemblies, enclosure seal tests, life tests, and performance tests that demonstrate that the GEMS lifetime is achievable. Finally we report performance measurements and the lifetime enhancement from the use of a getter.

Affordable Development and Optimization of CERMET Fuels for NTP Ground Testing

NASA Technical Reports Server (NTRS)

Hickman, Robert R.; Broadway, Jeramie W.; Mireles, Omar R.

2014-01-01

CERMET fuel materials for Nuclear Thermal Propulsion (NTP) are currently being developed at NASA's Marshall Space Flight Center. The work is part of NASA's Advanced Space Exploration Systems Nuclear Cryogenic Propulsion Stage (NCPS) Project. The goal of the FY12-14 project is to address critical NTP technology challenges and programmatic issues to establish confidence in the affordability and viability of an NTP system. A key enabling technology for an NCPS system is the fabrication of a stable high temperature nuclear fuel form. Although much of the technology was demonstrated during previous programs, there are currently no qualified fuel materials or processes. The work at MSFC is focused on developing critical materials and process technologies for manufacturing robust, full-scale CERMET fuels. Prototypical samples are being fabricated and tested in flowing hot hydrogen to understand processing and performance relationships. As part of this initial demonstration task, a final full scale element test will be performed to validate robust designs. The next phase of the project will focus on continued development and optimization of the fuel materials to enable future ground testing. The purpose of this paper is to provide a detailed overview of the CERMET fuel materials development plan. The overall CERMET fuel development path is shown in Figure 2. The activities begin prior to ATP for a ground reactor or engine system test and include materials and process optimization, hot hydrogen screening, material property testing, and irradiation testing. The goal of the development is to increase the maturity of the fuel form and reduce risk. One of the main accomplishmens of the current AES FY12-14 project was to develop dedicated laboratories at MSFC for the fabrication and testing of full length fuel elements. This capability will enable affordable, near term development and optimization of the CERMET fuels for future ground testing. Figure 2 provides a timeline of the development and optimization tasks for the AES FY15-17 follow on program.

Medical Image Processing Server applied to Quality Control of Nuclear Medicine.

NASA Astrophysics Data System (ADS)

Vergara, C.; Graffigna, J. P.; Marino, E.; Omati, S.; Holleywell, P.

2016-04-01

This paper is framed within the area of medical image processing and aims to present the process of installation, configuration and implementation of a processing server of medical images (MIPS) in the Fundación Escuela de Medicina Nuclear located in Mendoza, Argentina (FUESMEN). It has been developed in the Gabinete de Tecnologia Médica (GA.TE.ME), Facultad de Ingeniería-Universidad Nacional de San Juan. MIPS is a software that using the DICOM standard, can receive medical imaging studies of different modalities or viewing stations, then it executes algorithms and finally returns the results to other devices. To achieve the objectives previously mentioned, preliminary tests were conducted in the laboratory. More over, tools were remotely installed in clinical enviroment. The appropiate protocols for setting up and using them in different services were established once defined those suitable algorithms. Finally, it’s important to focus on the implementation and training that is provided in FUESMEN, using nuclear medicine quality control processes. Results on implementation are exposed in this work.

Adapting existing natural language processing resources for cardiovascular risk factors identification in clinical notes.

PubMed

Khalifa, Abdulrahman; Meystre, Stéphane

2015-12-01

The 2014 i2b2 natural language processing shared task focused on identifying cardiovascular risk factors such as high blood pressure, high cholesterol levels, obesity and smoking status among other factors found in health records of diabetic patients. In addition, the task involved detecting medications, and time information associated with the extracted data. This paper presents the development and evaluation of a natural language processing (NLP) application conceived for this i2b2 shared task. For increased efficiency, the application main components were adapted from two existing NLP tools implemented in the Apache UIMA framework: Textractor (for dictionary-based lookup) and cTAKES (for preprocessing and smoking status detection). The application achieved a final (micro-averaged) F1-measure of 87.5% on the final evaluation test set. Our attempt was mostly based on existing tools adapted with minimal changes and allowed for satisfying performance with limited development efforts. Copyright © 2015 Elsevier Inc. All rights reserved.

The development of an audit technique to assess the quality of safety barrier management.

PubMed

Guldenmund, Frank; Hale, Andrew; Goossens, Louis; Betten, Jeroen; Duijm, Nijs Jan

2006-03-31

This paper describes the development of a management model to control barriers devised to prevent major hazard scenarios. Additionally, an audit technique is explained that assesses the quality of such a management system. The final purpose of the audit technique is to quantify those aspects of the management system that have a direct impact on the reliability and effectiveness of the barriers and, hence, the probability of the scenarios involved. First, an outline of the management model is given and its elements are explained. Then, the development of the audit technique is described. Because the audit technique uses actual major hazard scenarios and barriers within these as its focus, the technique achieves a concreteness and clarity that many other techniques often lack. However, this strength is also its limitation, since the full safety management system is not covered with the technique. Finally, some preliminary experiences obtained from several test sites are compiled and discussed.

High efficiency and simple technique for controlling mechanisms by EMG signals

NASA Astrophysics Data System (ADS)

Dugarte, N.; Álvarez, A.; Balacco, J.; Mercado, G.; Gonzalez, A.; Dugarte, E.; Javier, F.; Ceballos, G.; Olivares, A.

2016-04-01

This article reports the development of a simple and efficient system that allows control of mechanisms through electromyography (EMG) signals. The novelty about this instrument is focused on individual control of each motion vector mechanism through independent electronic circuits. Each of electronic circuit does positions a motor according to intensity of EMG signal captured. This action defines movement in one mechanical axis considered from an initial point, based on increased muscle tension. The final displacement of mechanism depends on individual’s ability to handle the levels of muscle tension at different body parts. This is the design of a robotic arm where each degree of freedom is handled with a specific microcontroller that responds to signals taken from a defined muscle. The biophysical interaction between the person and the final positioning of the robotic arm is used as feedback. Preliminary tests showed that the control operates with minimal positioning error margins. The constant use of system with the same operator showed that the person adapts and progressively improves at control technique.

Delivering culturally sensitive health messages: the process of adapting brochures for grandparents raising grandchildren in Hawai'i.

PubMed

Yancura, Loriena A

2010-05-01

The efficacy of programs to reduce health disparities depends on their ability to deliver messages in a culturally sensitive manner. This article describes the process of designing a series of brochures for grandparents raising grandchildren. National source material on topics important to grandparents (self-care, service use, addiction, and grandchildren's difficult behaviors) was put into draft brochures and pilot tested in two focus groups drawn from Native Hawaiian Asian and Pacific Islander populations. Elements of surface and deep levels directed the form and content of the final brochures. On a surface level, these brochures reflect local culture through pictures and language. On a deep level, which integrates cultural beliefs and practices, they reflect the importance of indirect communication and harmonious relationships. The final brochures have been received favorably in the community. The process of adapting educational material with attention to surface and deep levels can serve as a guide for other health promotion materials.

A simulation model for predicting the temperature during the application of MR-guided focused ultrasound for stroke treatment using pulsed ultrasound

NASA Astrophysics Data System (ADS)

Hadjisavvas, V.; Damianou, C.

2011-09-01

In this paper a simulation model for predicting the temperature during the application of MR-guided focused ultrasound for stroke treatment using pulsed ultrasound is presented. A single element spherically focused transducer of 5 cm diameter, focusing at 10 cm and operating at either 0.5 MHz or 1 MHz was considered. The power field was estimated using the KZK model. The temperature was estimated using the bioheat equation. The goal was to extract the acoustic parameters (power, pulse duration, duty factor and pulse repetition frequency) that maintain a temperature increase of less than 1 °C during the application of a pulse ultrasound protocol. It was found that the temperature change increases linearly with duty factor. The higher the power, the lower the duty factor needed to keep the temperature change to the safe limit of 1 °C. The higher the frequency the lower the duty factor needed to keep the temperature change to the safe limit of 1 °C. Finally, the deeper the target, the higher the duty factor needed to keep the temperature change to the safe limit of 1 °C. The simulation model was tested in brain tissue during the application of pulse ultrasound and the measured temperature was in close agreement with the simulated temperature. This simulation model is considered to be very useful tool for providing acoustic parameters (frequency, power, duty factor, pulse repetition frequency) during the application of pulsed ultrasound at various depths in tissue so that a safe temperature is maintained during the treatment. This model could be tested soon during stroke clinical trials.

Additively Manufactured Combustion Devices Components for LOX/Methane Applications

NASA Technical Reports Server (NTRS)

Greene, Sandra Elam; Protz, Christopher; Garcia, Chance; Goodman, Dwight; Baker, Kevin

2016-01-01

Marshall Space Flight Center (MSFC) has designed, fabricated, and hot-fire tested a variety of successful injectors, chambers, and igniters for potential liquid oxygen (LOX) and methane (CH4) systems since 2005. The most recent efforts have focused on components with additive manufacturing (AM) to include unique design features, minimize joints, and reduce final machining efforts. Inconel and copper alloys have been used with AM processes to produce a swirl coaxial injector and multiple methane cooled thrust chambers. The initial chambers included unique thermocouple ports for measuring local coolant channel temperatures along the length of the chamber. Results from hot-fire testing were used to anchor thermal models and generate a regeneratively cooled thruster for a 4,000 lbf LOX/CH4 engine. The completed thruster will be hot-fire tested in the summer of 2016 at MSFC. The thruster design can also be easily scaled and used on a 25,000 lbf engine. To further support the larger engine design, an AM gas generator injector has been designed. Hot-fire testing on this injector is planned for the summer of 2016 at MSFC.

FAST Model Calibration and Validation of the OC5- DeepCwind Floating Offshore Wind System Against Wave Tank Test Data: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wendt, Fabian F; Robertson, Amy N; Jonkman, Jason

During the course of the Offshore Code Comparison Collaboration, Continued, with Correlation (OC5) project, which focused on the validation of numerical methods through comparison against tank test data, the authors created a numerical FAST model of the 1:50-scale DeepCwind semisubmersible system that was tested at the Maritime Research Institute Netherlands ocean basin in 2013. This paper discusses several model calibration studies that were conducted to identify model adjustments that improve the agreement between the numerical simulations and the experimental test data. These calibration studies cover wind-field-specific parameters (coherence, turbulence), hydrodynamic and aerodynamic modeling approaches, as well as rotor model (blade-pitchmore » and blade-mass imbalances) and tower model (structural tower damping coefficient) adjustments. These calibration studies were conducted based on relatively simple calibration load cases (wave only/wind only). The agreement between the final FAST model and experimental measurements is then assessed based on more-complex combined wind and wave validation cases.« less

Burnout and Coping Strategies in Male Staff from National Police in Valparaíso, Chile

PubMed Central

BRIONES MELLA, Daniel; KINKEAD BOUTIN, Ana P.

2013-01-01

Abstract Background This cross-sectional study aimed to examine the relationship between several dimensions of the burnout syndrome with certain stress-coping strategies, seniority level and marital status in male staff from National Police in Vaparaíso, Chile. Methods The sample collected in 2010 was composed of 338 male officers coming from various special units of a National Police in Valparaíso. Burnout and Coping Strategies were assessed and classified according Maslach Burnout Inventory (MBI) and COPE Inventory, respectively. Data was analyzed using Pearson product-moment correlation, t-test for independent measures and Multiple Linear Regression to generate a predictive model. Results The prevalence of the burnout syndrome disaggregated by grouping criteria, the dimensions concentrated in middle levels for emotional exhaustion with a 52.1%, a 51.8% for depersonalization and finally, personal achievement with a 48.8%. Only 28% of participants showed more exacerbated dimensions of the burnout syndrome. There was a weak and direct yet statistically significant relationship between personal achievement and active coping. Mental disconnection had a weak direct relationship between both coping strategies and emotional exhaustion also existed. Certain correlations between burnout dimensions and coping strategies focused on emotion as predictor variables over the criterion variable corresponding to emotional exhaustion were mental disconnection in first place, secondly, focusing on emotions, and emotional social support. Conclusions Burnout dimensions scored medium values ​​focusing mainly on emotional exhaustion and reduced personal accomplishment. Coping strategies are used in parallel and in general are not mutually exclusive. Finally, there were not any relationship between variables seniority level and marital status. PMID:26060656

Gerena School Health Impact Assessment (HIA) Final Report

EPA Pesticide Factsheets

This is the final report of the EPA-led Gerena Community School HIA, which aims to provide valuable health-focused information to help the City of Springfield narrow down and prioritize renovation actions at the school.

Practical Implementation of Semi-Automated As-Built Bim Creation for Complex Indoor Environments

NASA Astrophysics Data System (ADS)

Yoon, S.; Jung, J.; Heo, J.

2015-05-01

In recent days, for efficient management and operation of existing buildings, the importance of as-built BIM is emphasized in AEC/FM domain. However, fully automated as-built BIM creation is a tough issue since newly-constructed buildings are becoming more complex. To manage this problem, our research group has developed a semi-automated approach, focusing on productive 3D as-built BIM creation for complex indoor environments. In order to test its feasibility for a variety of complex indoor environments, we applied the developed approach to model the `Charlotte stairs' in Lotte World Mall, Korea. The approach includes 4 main phases: data acquisition, data pre-processing, geometric drawing, and as-built BIM creation. In the data acquisition phase, due to its complex structure, we moved the scanner location several times to obtain the entire point clouds of the test site. After which, data pre-processing phase entailing point-cloud registration, noise removal, and coordinate transformation was followed. The 3D geometric drawing was created using the RANSAC-based plane detection and boundary tracing methods. Finally, in order to create a semantically-rich BIM, the geometric drawing was imported into the commercial BIM software. The final as-built BIM confirmed that the feasibility of the proposed approach in the complex indoor environment.

Validation of vocational assessment tool for persons with substance use disorders.

PubMed

Sethuraman, Lakshmanan; Subodh, B N; Murthy, Pratima

2016-01-01

Work-related problems are a serious concern among persons with substance use but due to lack of a standardized tool to measure it; these problems are neither systematically assessed nor appropriately addressed. Most existing measures of work performance cater to the needs of the workplace rather than focusing on the workers' perception of the difficulties at work. To develop a standardized instrument to measure work-related problems in persons with substance use disorders. Qualitative data obtained from interviews with substance users were used to develop a scale. The refined list of the scale was circulated among an expert panel for content validation. The modified scale was administered to 150 cases, and 50 cases completed the scale twice at the interval of 2 weeks for test-retest reliability. Items with a test-retest reliability kappa coefficient of 0.4 or greater were retained and subjected to factor analysis. The final 45-item scale has a five-factor structure. The value of Cronbach's alpha of the final version of the scale was 0.91. This self-report questionnaire, which can be completed in 10 min, may help us in making a baseline assessment of the work-related impairment among persons with substance use and the impact of substance use on work.

Development of a dedicated ethanol ultra-low emission vehicle (ULEV): Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dodge, L.; Bourn, G.; Callahan, T.

The objective of this project was to develop a commercially competitive vehicle powered by ethanol (or an ethanol blend) that can meet California`s ultra-low emission vehicle (ULEV) standards and equivalent corporate average fuel economy (CAFE) energy efficiency for a light-duty passenger car application. The definition of commercially competitive is independent of fuel cost, but does include technical requirements for competitive power, performance, refueling times, vehicle range, driveability, fuel handling safety, and overall emissions performance. This report summarizes the fourth and final phase of this project, and also the overall project. The focus of this report is the technology used tomore » develop a dedicated ethanol-fueled ULEV, and the emissions results documenting ULV performance. Some of the details for the control system and hardware changes are presented in two appendices that are SAE papers. The demonstrator vehicle has a number of advanced technological features, but it is currently configured with standard original equipment manufacturer (OEM) under-engine catalysts. Close-coupled catalysts would improve emissions results further, but no close-coupled catalysts were available for this testing. Recently, close-coupled catalysts were obtained, but installation and testing will be performed in the future. This report also briefly summarizes work in several other related areas that supported the demonstrator vehicle work.« less

48 CFR 552.246-72 - Final Inspection and Tests.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Final Inspection and Tests. 552.246-72 Section 552.246-72 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 552.246-72 Final Inspection and Tests. As prescribed...

The impact of a disease management programme for type 2 diabetes on health-related quality of life: multilevel analysis of a cluster-randomised controlled trial.

PubMed

Panisch, Sigrid; Johansson, Tim; Flamm, Maria; Winkler, Henrike; Weitgasser, Raimund; Sönnichsen, Andreas C

2018-01-01

Type 2 diabetes is a chronic disease associated with poorer health outcomes and decreased health related quality of life (HRQoL). The aim of this analysis was to explore the impact of a disease management programme (DMP) in type 2 diabetes on HRQoL. A multilevel model was used to explain the variation in EQ-VAS. A cluster-randomized controlled trial-analysis of the secondary endpoint HRQoL. Our study population were general practitioners and patients in the province of Salzburg. The DMP "Therapie-Aktiv" was implemented in the intervention group, and controls received usual care. Outcome measure was a change in EQ-VAS after 12 months. For comparison of rates, we used Fisher's Exact test; for continuous variables the independent T test or Welch test were used. In the multilevel modeling, we examined various models, continuously adding variables to explain the variation in the dependent variable, starting with an empty model, including only the random intercept. We analysed random effects parameters in order to disentangle variation of the final EQ-VAS. The EQ-VAS significantly increased within the intervention group (mean difference 2.19, p = 0.005). There was no significant difference in EQ-VAS between groups (mean difference 1.00, p = 0.339). In the intervention group the improvement was more distinct in women (2.46, p = 0.036) compared to men (1.92, p = 0.063). In multilevel modeling, sex, age, family and work circumstances, any macrovascular diabetic complication, duration of diabetes, baseline body mass index and baseline EQ-VAS significantly influence final EQ-VAS, while DMP does not. The final model explains 28.9% (EQ-VAS) of the total variance. Most of the unexplained variance was found on patient-level (95%) and less on GP-level (5%). DMP "Therapie-Aktiv" has no significant impact on final EQ-VAS. The impact of DMPs in type 2 diabetes on HRQoL is still unclear and future programmes should focus on patient specific needs and predictors in order to improve HRQoL. Trial registration Current Controlled trials Ltd., ISRCTN27414162.

Development and validation of a patient-reported outcome measure for stroke patients.

PubMed

Luo, Yanhong; Yang, Jie; Zhang, Yanbo

2015-05-08

Family support and patient satisfaction with treatment are crucial for aiding in the recovery from stroke. However, current validated stroke-specific questionnaires may not adequately capture the impact of these two variables on patients undergoing clinical trials of new drugs. Therefore, the aim of this study was to develop and evaluate a new stroke patient-reported outcome measure (Stroke-PROM) instrument for capturing more comprehensive effects of stroke on patients participating in clinical trials of new drugs. A conceptual framework and a pool of items for the preliminary Stroke-PROM were generated by consulting the relevant literature and other questionnaires created in China and other countries, and interviewing 20 patients and 4 experts to ensure that all germane parameters were included. During the first item-selection phase, classical test theory and item response theory were applied to an initial scale completed by 133 patients with stroke. During the item-revaluation phase, classical test theory and item response theory were used again, this time with 475 patients with stroke and 104 healthy participants. During the scale assessment phase, confirmatory factor analysis was applied to the final scale of the Stroke-PROM using the same study population as in the second item-selection phase. Reliability, validity, responsiveness and feasibility of the final scale were tested. The final scale of Stroke-PROM contained 46 items describing four domains (physiology, psychology, society and treatment). These four domains were subdivided into 10 subdomains. Cronbach's α coefficients for the four domains ranged from 0.861 to 0.908. Confirmatory factor analysis supported the validity of the final scale, and the model fit index satisfied the criterion. Differences in the Stroke-PROM mean scores were significant between patients with stroke and healthy participants in nine subdomains (P < 0.001), indicating that the scale showed good responsiveness. The Stroke-PROM is a patient-reported outcome multidimensional questionnaire developed especially for clinical trials of new drugs and is focused on issues of family support and patient satisfaction with treatment. Extensive data analyses supported the validity, reliability and responsiveness of the Stroke-PROM.

A clinical perspective on the 2016 WHO brain tumor classification and routine molecular diagnostics.

PubMed

van den Bent, Martin J; Weller, Michael; Wen, Patrick Y; Kros, Johan M; Aldape, Ken; Chang, Susan

2017-05-01

The 2007 World Health Organization (WHO) classification of brain tumors did not use molecular abnormalities as diagnostic criteria. Studies have shown that genotyping allows a better prognostic classification of diffuse glioma with improved treatment selection. This has resulted in a major revision of the WHO classification, which is now for adult diffuse glioma centered around isocitrate dehydrogenase (IDH) and 1p/19q diagnostics. This revised classification is reviewed with a focus on adult brain tumors, and includes a recommendation of genes of which routine testing is clinically useful. Apart from assessment of IDH mutational status including sequencing of R132H-immunohistochemistry negative cases and testing for 1p/19q, several other markers can be considered for routine testing, including assessment of copy number alterations of chromosome 7 and 10 and of TERT promoter, BRAF, and H3F3A mutations. For "glioblastoma, IDH mutated" the term "astrocytoma grade IV" could be considered. It should be considered to treat IDH wild-type grades II and III diffuse glioma with polysomy of chromosome 7 and loss of 10q as glioblastoma. New developments must be more quickly translated into further revised diagnostic categories. Quality control and rapid integration of molecular findings into the final diagnosis and the communication of the final diagnosis to clinicians require systematic attention. © The Author(s) 2017. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Item Banks for Substance Use from the Patient-Reported Outcomes Measurement Information System (PROMIS®): Severity of Use and Positive Appeal of Use*

PubMed Central

Pilkonis, Paul A.; Yu, Lan; Dodds, Nathan E.; Johnston, Kelly L.; Lawrence, Suzanne; Hilton, Thomas F.; Daley, Dennis C.; Patkar, Ashwin A.; McCarty, Dennis

2015-01-01

Background Two item banks for substance use were developed as part of the Patient-Reported Outcomes Measurement Information System (PROMIS®): severity of substance use and positive appeal of substance use. Methods Qualitative item analysis (including focus groups, cognitive interviewing, expert review, and item revision) reduced an initial pool of more than 5,300 items for substance use to 119 items included in field testing. Items were written in a first-person, past-tense format, with 5 response options reflecting frequency or severity. Both 30-day and 3-month time frames were tested. The calibration sample of 1,336 respondents included 875 individuals from the general population (ascertained through an internet panel) and 461patients from addiction treatment centers participating in the National Drug Abuse Treatment Clinical Trials Network. Results Final banks of 37 and 18 items were calibrated for severity of substance use and positive appeal of substance use, respectively, using the two-parameter graded response model from item response theory (IRT). Initial calibrations were similar for the 30-day and 3-month time frames, and final calibrations used data combined across the time frames, making the items applicable with either interval. Seven-item static short forms were also developed from each item bank. Conclusions Test information curves showed that the PROMIS item banks provided substantial information in a broad range of severity, making them suitable for treatment, observational, and epidemiological research in both clinical and community settings. PMID:26423364

The development of the Pictorial Thai Quality of Life.

PubMed

Phattharayuttawat, Sucheera; Ngamthipwatthana, Thienchai; Pitiyawaranun, Buncha

2005-11-01

"Quality of life" has become a main focus of interest in medicine. The Pictorial Thai Quality of Life (PTQL) was developed in order to measure the Thai mental illness both in a clinical setting and community. The purpose of this study was to develop the Pictorial Thai Quality of Life (PTQL), having adequate and sufficient construct validity, discriminant power, concurrent validity, and reliability. To develop the Pictorial Thai Quality of Life Test, two samples groups were used in the present study: (1) pilot study samples: 30 samples and (2) survey samples were 672 samples consisting of normal, and psychiatric patients. The developing tests items were collected from a review of the literature in which all the items were based on the WHO definition of Quality of Life. Then, experts judgment by the Delphi technique was used in the first stage. After that a pilot study was used to evaluate the testing administration, and wording of the tests items. The final stage was collected data from the survey samples. The results of the present study showed that the final test was composed 25 items. The construct validity of this test consists of six domains: Physical, Cognitive, Affective, Social Function, Economic and Self-Esteem. All the PTQL items have sufficient discriminant power It was found to be statistically significant different at the. 001 level between those people with mental disorders and normal people. There was a high level of concurrent validity association with WHOQOL-BREF, Pearson correlation coefficient and Area under ROC curve were 0.92 and 0.97 respectively. The reliability coefficients for the Alpha coefficients of the PTQL total test was 0.88. The values of the six scales were from 0.81 to 0:91. The present study was directed at developing an effective psychometric properties pictorial quality of life questionnaire. The result will be a more direct and meaningful application of an instrument to detect the mental health illness poor quality of life in Thai communities.

Secure Retrieval of FFTF Testing, Design, and Operating Information

DOE Office of Scientific and Technical Information (OSTI.GOV)

Butner, R. Scott; Wootan, David W.; Omberg, Ronald P.

One of the goals of the Advanced Fuel Cycle Initiative (AFCI) is to preserve the knowledge that has been gained in the United States on Liquid Metal Reactors (LMR). In addition, preserving LMR information and knowledge is part of a larger international collaborative activity conducted under the auspices of the International Atomic Energy Agency (IAEA). A similar program is being conducted for EBR-II at the Idaho Nuclear Laboratory (INL) and international programs are also in progress. Knowledge preservation at the FFTF is focused on the areas of design, construction, startup, and operation of the reactor. As the primary function ofmore » the FFTF was testing, the focus is also on preserving information obtained from irradiation testing of fuels and materials. This information will be invaluable when, at a later date, international decisions are made to pursue new LMRs. In the interim, this information may be of potential use for international exchanges with other LMR programs around the world. At least as important in the United States, which is emphasizing large-scale computer simulation and modeling, this information provides the basis for creating benchmarks for validating and testing these large scale computer programs. Although the preservation activity with respect to FFTF information as discussed below is still underway, the team of authors above is currently retrieving and providing experimental and design information to the LMR modeling and simulation efforts for use in validating their computer models. On the Hanford Site, the FFTF reactor plant is one of the facilities intended for decontamination and decommissioning consistent with the cleanup mission on this site. The reactor facility has been deactivated and is being maintained in a cold and dark minimal surveillance and maintenance mode until final decommissioning is pursued. In order to ensure protection of information at risk, the program to date has focused on sequestering and secure retrieval. Accomplishments include secure retrieval of: more than 400 boxes of FFTF information, several hundred microfilm reels including Clinch River Breeder Reactor (CRBR) information, and 40 boxes of information on the Fuels and Materials Examination Facility (FMEF). All information preserved to date is now being stored and categorized consistent with the IAEA international standardized taxonomy. Earlier information largely related to irradiation testing is likewise being categorized. The fuel test results information exists in several different formats depending upon the final stage of the test evaluation. In some cases there is information from both non-destructive and destructive examination while in other cases only non-destructive results are available. Non-destructive information would include disassembly records, dimensional profilometry, gamma spectrometry, and neutron radiography. Information from destructive examinations would include fission gas analysis, metallography, and photomicrographs. Archiving of FFTF data, including both the reactor plant and the fuel test information, is being performed in coordination with other data archiving efforts underway under the aegis of the AFCI program. In addition to the FFTF efforts, archiving of data from the EBR-II reactor is being carried out by INL. All material at risk associated with FFTF documentation has been secured in a timely manner consistent with the stated plan. This documentation is now being categorized consistent with internationally agreed upon IAEA standards. Documents are being converted to electronic format for transfer to a large searchable electronic database being developed by INL. In addition, selected FFTF information is being used to generate test cases for large-scale simulation modeling efforts and for providing Design Data Need (DDN) packages as requested by the AFCI program.« less

The effects of initial testing on false recall and false recognition in the social contagion of memory paradigm.

PubMed

Huff, Mark J; Davis, Sara D; Meade, Michelle L

2013-08-01

In three experiments, participants studied photographs of common household scenes. Following study, participants completed a category-cued recall test without feedback (Exps. 1 and 3), a category-cued recall test with feedback (Exp. 2), or a filler task (no-test condition). Participants then viewed recall tests from fictitious previous participants that contained erroneous items presented either one or four times, and then completed final recall and source recognition tests. The participants in all conditions reported incorrect items during final testing (a social contagion effect), and across experiments, initial testing had no impact on false recall of erroneous items. However, on the final source-monitoring recognition test, initial testing had a protective effect against false source recognition: Participants who were initially tested with and without feedback on category-cued initial tests attributed fewer incorrect items to the original event on the final source-monitoring recognition test than did participants who were not initially tested. These data demonstrate that initial testing may protect individuals' memories from erroneous suggestions.

Black-Box System Testing of Real-Time Embedded Systems Using Random and Search-Based Testing

NASA Astrophysics Data System (ADS)

Arcuri, Andrea; Iqbal, Muhammad Zohaib; Briand, Lionel

Testing real-time embedded systems (RTES) is in many ways challenging. Thousands of test cases can be potentially executed on an industrial RTES. Given the magnitude of testing at the system level, only a fully automated approach can really scale up to test industrial RTES. In this paper we take a black-box approach and model the RTES environment using the UML/MARTE international standard. Our main motivation is to provide a more practical approach to the model-based testing of RTES by allowing system testers, who are often not familiar with the system design but know the application domain well-enough, to model the environment to enable test automation. Environment models can support the automation of three tasks: the code generation of an environment simulator, the selection of test cases, and the evaluation of their expected results (oracles). In this paper, we focus on the second task (test case selection) and investigate three test automation strategies using inputs from UML/MARTE environment models: Random Testing (baseline), Adaptive Random Testing, and Search-Based Testing (using Genetic Algorithms). Based on one industrial case study and three artificial systems, we show how, in general, no technique is better than the others. Which test selection technique to use is determined by the failure rate (testing stage) and the execution time of test cases. Finally, we propose a practical process to combine the use of all three test strategies.

A review of the basis of the immunological diagnosis of ruminant brucellosis.

PubMed

Ducrotoy, Marie J; Conde-Álvarez, Raquel; Blasco, José María; Moriyón, Ignacio

2016-03-01

Bacteria of the genus Brucella cause brucellosis, the most common bacterial zoonosis worldwide. The diagnosis of Brucella abortus and Brucella melitensis ruminant brucellosis is based on bacteriological and immunological tests, the latter being routinely used in control and eradication and surveillance programs. Infections by smooth and rough Brucella spp., the use of smooth and rough vaccines, and the false-positive serological reactions caused by Yersinia enterocolitica O:9 and other cross-reacting bacteria represent the immunological contexts in which those tests are used. This complex context explains the large number of brucellosis tests that have been developed, and that vary in antigen type, antigen presentation, antibody and conditions for the reaction, the response detected and the sample required. This wealth of information and an imperfect understanding of Brucella antigens and of the peculiarities of the immunoresponse to Brucella has created confusion and led to several misconceptions on the usefulness and limitations of the brucellosis diagnostic tests. In this review, Brucella antigens are examined focusing on cellular topology, supramolecular properties, epitopic structure and lipopolysaccharide and protein cross-reactivity in the various contexts of the immune response in ruminants. Then, the significance of these features in diagnostic tests that use whole bacteria is discussed with respect to the activities of ruminant immunoglobulins, and the effect of pH on unspecific agglutinations, non-agglutinating and blocking antibodies, pseudo-prozones and complement activation. Similarly, the bacterial surface lipopolysaccharides and cognate polysaccharides are discussed with regards to topological effects, epitope exposure, ionic strength and antibody avidity in immunoprecipitation, immunosorbent and fluorescence polarization assays. Finally, the search for immunodominant protein antigens and their use in immunological tests is reviewed. Critical review of the existing information is necessary both to select optimal tests according to the logistical means available and the epidemiological context, and to focus the development of new tests. Copyright © 2016 Elsevier B.V. All rights reserved.

Grooming ten-year-olds with gender stereotypes? A content analysis of preteen and teen girl magazines.

PubMed

Daniels, Elizabeth A; Layh, Marlee C; Porzelius, Linda K

2016-12-01

Extensive research shows a strong body focus in media aimed at teen girls and adult women; less is known about the content of media aimed at preteen girls. The present study investigated differences in the content of preteen versus teen girl magazines. Additionally, the content of independent compared to mainstream magazines was examined. Media frames, which are dominant themes present in media stories, used in content about the body were examined. Finally, the prevalence of appearance-focused versus non-appearance-focused content was assessed. Advertisements and general stories were analyzed. Results indicate that teen and mainstream magazines contained more appearance content than preteen and independent magazines. Appearance media frames were more common in teen than preteen magazines. Finally, teen and mainstream magazines contained more appearance-focused than non-appearance-focused content, whereas the opposite was true for preteen and independent magazines. Findings are discussed in terms of objectification theory and gender socialization practices. Copyright © 2016 Elsevier Ltd. All rights reserved.

Snow removal performance metrics : final report.

DOT National Transportation Integrated Search

2017-05-01

This document is the final report for the Clear Roads project entitled Snow Removal Performance Metrics. The project team was led by researchers at Washington State University on behalf of Clear Roads, an ongoing pooled fund research effort focused o...

Transport and installation of the Dark Energy Survey CCD imager

NASA Astrophysics Data System (ADS)

Derylo, Greg; Chi, Edward; Diehl, H. Thomas; Estrada, Juan; Flaugher, Brenna; Schultz, Ken

2012-09-01

The Dark Energy Survey CCD imager was constructed at the Fermi National Accelerator Laboratory and delivered to the Cerro Tololo Inter-American Observatory in Chile for installation onto the Blanco 4m telescope. Several efforts are described relating to preparation of the instrument for transport, development and testing of a shipping crate designed to minimize transportation loads transmitted to the camera, and inspection of the imager upon arrival at the observatory. Transportation loads were monitored and are described. For installation of the imager at the telescope prime focus, where it mates with its previously-installed optical corrector, specialized tooling was developed to safely lift, support, and position the vessel. The installation and removal processes were tested on the Telescope Simulator mockup at FNAL, thus minimizing technical and schedule risk for the work performed at CTIO. Final installation of the imager is scheduled for August 2012.

Male contraceptive technology for nonhuman male mammals.

PubMed

Bowen, R A

2008-04-01

Contraceptive techniques applied to males have potential to mitigate diverse instances of overpopulation in human and animal populations. Different situations involving different species dictate that there is no ideal male contraceptive, and emphasizes the value of varying approaches to reducing male fertility. A majority of work in this field has focused on non-surgically destroying the testes or obstructing the epididymis, and suppressing gonadotropin secretion or inducing immune responses to reproductive hormones or sperm-specific antigens. Injection of tissue-destructive agents into the testes or epididymides can be very effective, but often is associated with unacceptable inflammatory responses and sometimes pain. Hormonal vaccines are often not efficacious and provide only short-term contraception, although GnRH vaccines may be an exception to this generality. Finally, there are no clearly effective contraceptive vaccines based on sperm antigens. Although several techniques have been developed to the point of commercialization, none has yet been widely deployed other than surgical castration.

New technique for study on isotopic fractionation between sea water and foraminiferal growing processes

NASA Astrophysics Data System (ADS)

Cang, Shuxi; Shackleton, N. J.

1990-12-01

The stable isotopic δ18O and δ13C composition of foraminiferal shell calcite varies as a function of many factors including temperature and salinity. In order to understand and interpret the variations in the isotopic composition of foraminiferal shell calcite, research has been recently focused on the role of the “vital effects”. Our examination of the lamella structure of several recent planktonic foraminifera indicates that the secretion of sequential lamellae results in multiple lamillae on earlier chambers and a single lamella on the final chamber. We used a very simple procedure to separate the individual whole test of foraminifera into several chambers and measured the isotopic composition of each growth stage chamber. The results indicate that the stable isotopic composition (carbon and oxygen), particularly that of the last two chambers, of the foraminiferal test varies as a function of the individual growing process.

Blade Displacement Predictions for the Full-Scale UH-60A Airloads Rotor

NASA Technical Reports Server (NTRS)

Bledron, Robert T.; Lee-Rausch, Elizabeth M.

2014-01-01

An unsteady Reynolds-Averaged Navier-Stokes solver for unstructured grids is loosely coupled to a rotorcraft comprehensive code and used to simulate two different test conditions from a wind-tunnel test of a full-scale UH-60A rotor. Performance data and sectional airloads from the simulation are compared with corresponding tunnel data to assess the level of fidelity of the aerodynamic aspects of the simulation. The focus then turns to a comparison of the blade displacements, both rigid (blade root) and elastic. Comparisons of computed root motions are made with data from three independent measurement systems. Finally, comparisons are made between computed elastic bending and elastic twist, and the corresponding measurements obtained from a photogrammetry system. Overall the correlation between computed and measured displacements was good, especially for the root pitch and lag motions and the elastic bending deformation. The correlation of root lead-lag motion and elastic twist deformation was less favorable.

Decision-Level Fusion of Spatially Scattered Multi-Modal Data for Nondestructive Inspection of Surface Defects

PubMed Central

Heideklang, René; Shokouhi, Parisa

2016-01-01

This article focuses on the fusion of flaw indications from multi-sensor nondestructive materials testing. Because each testing method makes use of a different physical principle, a multi-method approach has the potential of effectively differentiating actual defect indications from the many false alarms, thus enhancing detection reliability. In this study, we propose a new technique for aggregating scattered two- or three-dimensional sensory data. Using a density-based approach, the proposed method explicitly addresses localization uncertainties such as registration errors. This feature marks one of the major of advantages of this approach over pixel-based image fusion techniques. We provide guidelines on how to set all the key parameters and demonstrate the technique’s robustness. Finally, we apply our fusion approach to experimental data and demonstrate its capability to locate small defects by substantially reducing false alarms under conditions where no single-sensor method is adequate. PMID:26784200

Hepatic encephalopathy

PubMed Central

2017-01-01

Abstract Hepatic encephalopathy (HE) is a reversible syndrome of impaired brain function occurring in patients with advanced liver diseases. The precise pathophysiology of HE is still under discussion; the leading hypothesis focus on the role of neurotoxins, impaired neurotransmission due to metabolic changes in liver failure, changes in brain energy metabolism, systemic inflammatory response and alterations of the blood brain barrier. HE produces a wide spectrum of nonspecific neurological and psychiatric manifestations. Minimal HE is diagnosed by abnormal psychometric tests. Clinically overt HE includes personality changes, alterations in consciousness progressive disorientation in time and space, somnolence, stupor and, finally, coma. Except for clinical studies, no specific tests are required for diagnosis. HE is classified according to the underlying disease, the severity of manifestations, its time course and the existence of precipitating factors. Treatment of overt HE includes supportive therapies, treatment of precipitating factors, lactulose and/or rifaximin. Routine treatment for minimal HE is only recommended for selected patients. PMID:28533911

D-Area Drip Irrigation-Phytoremediation Project: SRTC Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wilde, E.W.

2003-01-14

Groundwater in D-Area at the Savannah River Site (SRS) is contaminated with trichloroethylene (TCE) and by-products resulting from discharges of this organic solvent during past operations. Several potential clean-up strategies are being or have been investigated, including a novel drip irrigation-phytoremediation process that is the focus of the treatability study described in this report. The contaminated groundwater in D-Area occurs primarily at depths of 30 to 50 feet below ground surface, well below the depths that are typically penetrated by plant roots. The system investigated in this study involved pumping water from the contaminated aquifer and discharging the water intomore » overlying test plots below the surface using drip irrigation. The test plots contained pines, cottonwoods, or no vegetation (controls). The primary objective was to determine the overall effectiveness of the process for TCE removal and to elucidate the biotic and abiotic pathways for its removal.« less

Towards a better control of optics cleanliness

NASA Astrophysics Data System (ADS)

Berlioz, P.

2017-11-01

The contamination of optics can considerably degrade the transmission and scattering of spacecraft optics. To prevent efficiently optics from contamination involves introducing since design phase requirements on materials and protections (covers…). Then, integration and test phase demands to implement heavy and stringent means (clean room, specific garment, covers…) and a permanent monitoring by fine contamination measurement of instrument environment and surfaces. Contamination budgets are drawn the project along, first prediction budgets based on analysis and potentially modeling, during design phase, then actual budgets based on contamination measurement during integration and test phase. Finally, the risk still exists to have to clean optics because of hazardous contamination, furthermore to dismount them. The cleanliness engineering set at ASTRIUM Toulouse is presented here, including the contamination monitoring via witness samples measured by IR spectrometry and via counters. ASTRIUM is presently focusing attention on no contact cleaning like the promising UV-ozone process.

An Update of the Nation's Long-Term Strategic Needs for NASA's Aeronautics Test Facilities

NASA Technical Reports Server (NTRS)

Anton, Philip S.; Raman, Raj; Osburg, Jan; Kallimani, James G.

2009-01-01

The National Aeronautics and Space Administration's (NASA's) major wind tunnel (WT), propulsion test (PT), and simulation facilities exist to serve NASA's and the nation's aeronautics needs. RAND Corporation researchers conducted a prior study of these facilities from 2002 to 2003, identifying (1) NASA's continuing ability to serve national needs, (2) which facilities appear strategically important from an engineering perspective given the vehicle classes the nation investigates and produces, and (3) management challenges and issues. This documented briefing (DB) is the final report from a new, one-year study (conducted from September 2006 through January 2008), partially updating the prior assessment. The study focuses on updating the list of facilities in the prior study that were deemed to be strategically important (again, from an engineering perspective) in serving those needs. This update also adds a new assessment of national needs for six major aeronautics simulators at NASA and lists those deemed strategically important.

Experimental study on hydraulic characteristic around trash rack of a pumping station

NASA Astrophysics Data System (ADS)

Zhou, MinZhe; Li, TongChun; Lin, XiangYang; Liu, XiaoQing; Ding, Yuan; Liu, GuangYuan

2017-11-01

This paper focuses on flow pattern around trash rack of intake of a pumping station project. This pumping station undertake the task of supplying up to 3,500,000 m3 water per day for a megacity. Considering the large flow rate, high lift, multi-pipe supply and long-time operation in this water conveyance pumping station, we built a physical model test to measure the flow velocity and observe the flow pattern to verify the reasonability of preliminary design. In this test, we set 3 layers of current meters around each trash rack of intake in reservoir to collect the flow velocity. Furthermore, we design 2 operating conditions of 9 pumps to observe the change of flow pattern. Finally, we found the velocity data were in a normal range under 2 different operating conditions of the 9 pump units.

A conceptual design study of point focusing thin-film solar concentrators

NASA Technical Reports Server (NTRS)

1981-01-01

Candidates for reflector panel design concepts, including materials and configurations, were identified. The large list of candidates was screened and reduced to the five most promising ones. Cost and technical factors were used in making the final choices for the panel conceptual design, which was a stiffened steel skin substrate with a bonded, acrylic overcoated, aluminized polyester film reflective surface. Computer simulations were run for the concentrator optics using the selected panel design, and experimentally determined specularity and reflectivity values. Intercept factor curves and energy to the aperture curves were produced. These curves indicate that surface errors of 2 mrad (milliradians) or less would be required to capture the desired energy for a Brayton cycle 816 C case. Two test panels were fabricated to demonstrate manufacturability and optically tested for surface error. Surface errors in the range of 1.75 mrad and 2.2 mrad were measured.

Formulation and Evaluation of a Novel Adhesive Film for Use in Composite Patch Repair

NASA Astrophysics Data System (ADS)

Tsamasphyros, G.; Kalkanis, K.; Maroulas, P.; Anthoulis, G. I.; Grigoryeva, O.

2008-08-01

The current work focuses on the testing of a novel material used as an adhesive film in Composite Patch Repair (CPR). A series of Differential Scanning Calorimetry (DSC) results along with various curing cycles not only led to the optimum material composition but also demonstrated the compatibility to the composite pre-impregnated patches. This in turn was subjected to mechanical testing including shear strength measurements. The substrate was chosen to be 2017 T4 aluminium alloy which is customarily used in the aerospace industry, taking into account that CPR is a technique mainly applied in this field. The subsequent surface preparation of the specimens was investigated for the specified context resulting to the selection of the Ferric Sulphate Sulphuric acid etching process. Finally, a series of specimens representing actual skin repairs were created and subjected to cyclic loading, specifying the suitability of the novel material, compared to commercially available materials.

Point-of-Care Testing: General Aspects.

PubMed

Ferreira, Carlos E S; Guerra, Joao C C; Slhessarenko, Natasha; Scartezini, Marileia; Franca, Carolina N; Colombini, Marjorie P; Berlitz, Fernando; Machado, Antonia M O; Campana, Gustavo A; Faulhaber, Adriana C L; Galoro, Cesar A; Dias, Claudia M; Shcolnik, Wilson; Martino, Marines D V; Cesar, Katia R; Sumita, Nairo M; Mendes, Maria E; Faulhaber, Marcelo H W; Pinho, Joao R R; Barbosa, Ismar V; Batista, Marcelo C; Khawali, Cristina; Pariz, Vitor M; Andriolo, Adagmar

2018-01-01

Point-of-Care Testing (POCT) has been highlighted in the health care sector in recent decades. On the other hand, due to its low demand, POCT is at a disadvantage compared to conventional equipment, since its cost is inversely proportional to the volume of use. In addition, for the implementation of POCT to succeed, it is essential to rely on the work of a multidisciplinary team. The awareness of health professionals of the importance of each step is perhaps the critical success factor. The trend towards the continuous advancement of the use of POCT and the great potential of its contributions reinforce the need to implement quality management tools, including performance indicators, to ensure their results. This review presents some advantages and disadvantages concerning POCT and the real need to use it. A worldwide call for the availability of easy-to-use health technologies that are increasingly closer to the final user is one of the main reasons for this focus.

Laser re-manufacturing of failure 18Cr2Ni4WA gear in low-speed heavy-load mining machine transmission

NASA Astrophysics Data System (ADS)

Chi, X. F.

2017-10-01

This article investigated laser re-manufacturing technology application in mining industry. The research focused on green re-manufacturing of failure spur. Leave the main gear body stay intact after the dirty, rust, fatigue and injured part were removed completely before the green re-manufacturing procedure begin. The optimized laser operating parameters paved the road for excellent mechanical properties and comparatively neat shape which often means less post processing. The laser re-manufactured gear surface was systematically examined, including microstructure observation, and dry wear test at room temperature. The test results were compared with new gear surface and used but not broken gear surface. Finally, it proved that the green re-manufactured gear surface displayed best comprehensive mechanical properties, followed the new gear surface. The resistance of dry wear properties of used but not broken gear surface was the worst.

SEQUenCE: a service user-centred quality of care instrument for mental health services.

PubMed

Hester, Lorraine; O'Doherty, Lorna Jane; Schnittger, Rebecca; Skelly, Niamh; O'Donnell, Muireann; Butterly, Lisa; Browne, Robert; Frorath, Charlotte; Morgan, Craig; McLoughlin, Declan M; Fearon, Paul

2015-08-01

To develop a quality of care instrument that is grounded in the service user perspective and validate it in a mental health service. The instrument (SEQUenCE (SErvice user QUality of CarE)) was developed through analysis of focus group data and clinical practice guidelines, and refined through field-testing and psychometric analyses. All participants were attending an independent mental health service in Ireland. Participants had a diagnosis of bipolar affective disorder (BPAD) or a psychotic disorder. Twenty-nine service users participated in six focus group interviews. Seventy-one service users participated in field-testing: 10 judged the face validity of an initial 61-item instrument; 28 completed a revised 52-item instrument from which 12 items were removed following test-retest and convergent validity analyses; 33 completed the resulting 40-item instrument. Test-retest reliability, internal consistency and convergent validity of the instrument. The final instrument showed acceptable test-retest reliability at 5-7 days (r = 0.65; P < 0.001), good convergent validity with the Verona Service Satisfaction Scale (r = 0.84, P < 0.001) and good internal consistency (Cronbach's alpha = 0.87). SEQUenCE is a valid, reliable scale that is grounded in the service user perspective and suitable for routine use. It may serve as a useful tool in individual care planning, service evaluation and research. The instrument was developed and validated with service users with a diagnosis of either BPAD or a psychotic disorder; it does not yet have established external validity for other diagnostic groups. © The Author 2015. Published by Oxford University Press in association with the International Society for Quality in Health Care; all rights reserved.

A Focus on Cryogenic Engineering for the Primordial Inflation Polarization Explorer (PIPER) Mission

NASA Technical Reports Server (NTRS)

Rosas, Rogelio; Weston, Amy

2011-01-01

Cryogenic engineering involves design and modification of equipment that is used under boiling point of nitrogen which is 77 K. The focus of this paper will be on the design of hardware for cryogenic use and a retrofit that was done to the main laboratory cryostat used to test flight components for the Primordial Inflation Polarization Explorer balloon-borne mission. Data from prior tests showed that there was a superfluid helium leak and a total disassemble of the cryostat was conducted in order to localize and fix the leak. To improve efficiency new fill tubes and clamps with modifications were added to the helium tank. Upon removal of the tank, corrosion was found on the flange face that connects to the helium cold plate and therefore had to be fully replaced and copper plated to prevent future corrosion. Indium seals were also replaced for the four fill tubes, a helium level sensor, and the nitrogen and helium tanks. Four additional shielded twisted pairs of cryogenic wire and a wire harness for the Superconducting Quantum Interference Devices (SQUIDs) were added. Finally, there was also design work done for multiple pieces that went inside the cryostat and a separate probe used to test the SQUIDs. Upon successful completion of the cryostat upgrade, tests were run to check the effectiveness and stability of the upgrades. The post-retrofit tests showed minor leaks were still present and due to this, superfluidity has still not been attained. As such there could still be a possibility of a superfluid leak appearing in the future. Regardless, the copper plating on the helium tank has elongated the need to service it by three to five years.

Teaching pain recognition through art: the Ramsay-Caravaggio sedation scale.

PubMed

Poropat, Federico; Cozzi, Giorgio; Magnolato, Andrea; Monasta, Lorenzo; Borrometi, Fabio; Krauss, Baruch; Ventura, Alessandro; Barbi, Egidio

2018-01-31

Clinical observation is a key component of medical ability, enabling immediate evaluation of the patient's emotional state and contributing to a clinical clue that leads to final decision making. In medical schools, the art of learning to look can be taught using medical humanities and especially visual arts. By presenting a Ramsay sedation score (RSS) integrated with Caravaggio's paintings during a procedural sedation conference for pediatric residents, we want to test the effectiveness of this approach to improve the quality of learning. In this preliminary study, we presented videos showing sedated pediatric patients in the setting of a procedural sedation lesson to two randomized groups of residents, one attending a lesson on RSS explained through the masterpieces of Caravaggio, the other without artistic support. A week later we tested their learning with ten multi-choice questions focused on theoretical questions about sedation monitoring and ten more questions focused on recognizing the appropriate RSS viewing the videos. The primary outcome was the comparison of the total number of RSS layers properly recognized in both groups. We also evaluated the appreciation of the residents of the use of works of art integrated with the lesson. Eleven students were randomized to each group. Two residents in the standard lesson did not attend the test. The percentage of correct answers on the theoretical part was similar, 82% in the art group and 89% in the other (p > 0.05). No difference was found in the video recognition part of the RSS recognition test. Residents exposed to paintings shown great appreciation for the integration of the lesson with the Caravaggio's masterpieces. Adding artwork to a standard medical conference does not improve the performance of student tests, although this approach has been greatly appreciated by residents.

Single-Crystal Sapphire Optical Fiber Sensor Instrumentation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pickrell, Gary; Scott, Brian; Wang, Anbo

2013-12-31

This report summarizes technical progress on the program “Single-Crystal Sapphire Optical Fiber Sensor Instrumentation,” funded by the National Energy Technology Laboratory of the U.S. Department of Energy, and performed by the Center for Photonics Technology of the Bradley Department of Electrical and Computer Engineering at Virginia Tech. This project was completed in three phases, each with a separate focus. Phase I of the program, from October 1999 to April 2002, was devoted to development of sensing schema for use in high temperature, harsh environments. Different sensing designs were proposed and tested in the laboratory. Phase II of the program, frommore » April 2002 to April 2009, focused on bringing the sensor technologies, which had already been successfully demonstrated in the laboratory, to a level where the sensors could be deployed in harsh industrial environments and eventually become commercially viable through a series of field tests. Also, a new sensing scheme was developed and tested with numerous advantages over all previous ones in Phase II. Phase III of the program, September 2009 to December 2013, focused on development of the new sensing scheme for field testing in conjunction with materials engineering of the improved sensor packaging lifetimes. In Phase I, three different sensing principles were studied: sapphire air-gap extrinsic Fabry-Perot sensors; intensity-based polarimetric sensors; and broadband polarimetric sensors. Black body radiation tests and corrosion tests were also performed in this phase. The outcome of the first phase of this program was the selection of broadband polarimetric differential interferometry (BPDI) for further prototype instrumentation development. This approach is based on the measurement of the optical path difference (OPD) between two orthogonally polarized light beams in a single-crystal sapphire disk. At the beginning of Phase II, in June 2004, the BPDI sensor was tested at the Wabash River coal gasifier facility in Terre Haute, Indiana. Due to business conditions at industrial partner and several logistical problems, this field test was not successful. An alternative high-temperature sensing system using sapphire wafer-based extrinsic Fabry-Perot interferometry was then developed as a significant improvement over the BPDI solution. From June 2006 to June 2008, three consecutive field tests were performed with the new sapphire wafer sensors at the TECO coal gasifier in Tampa, Florida. One of the sensors survived in the industrial coal gasifier for 7 months, over which time the existing thermocouples were replaced twice. The outcome of these TECO field tests suggests that the sapphire wafer sensor has very good potential to be commercialized. However packaging and sensor protection issues need additional development. During Phase III, several major improvements in the design and fabrication process of the sensor have been achieved through experiments and theoretical analysis. Studies on the property of the key components in the sensor head, including the sapphire fiber and sapphire wafer, were also conducted, for a better understanding of the sensor behavior. A final design based on all knowledge and experience has been developed, free of any issues encountered during the entire research. Sensors with this design performed well as expected in lab long-term tests, and were deployed in the sensing probe of the final coal-gasifier field test. Sensor packaging and protection was improved through materials engineering through testing of packaging designs in two blank probe packaging tests at Eastman Chemical in Kingsport, TN. Performance analysis of the blank probe packaging resulted in improve package designs culminating in a 3rd generation probe packaging utilized for the full field test of the sapphire optical sensor and materials designed sensor packaging.« less

Validation of the Lockheed Martin Morphing Concept with Wind Tunnel Testing

NASA Technical Reports Server (NTRS)

Ivanco, Thomas G.; Scott, Robert C.; Love, Michael H.; Zink Scott; Weisshaar, Terrence A.

2007-01-01

The Morphing Aircraft Structures (MAS) program is a Defense Advanced Research Projects Agency (DARPA) led effort to develop morphing flight vehicles capable of radical shape change in flight. Two performance parameters of interest are loiter time and dash speed as these define the persistence and responsiveness of an aircraft. The geometrical characteristics that optimize loiter time and dash speed require different geometrical planforms. Therefore, radical shape change, usually involving wing area and sweep, allows vehicle optimization across many flight regimes. The second phase of the MAS program consisted of wind tunnel tests conducted at the NASA Langley Transonic Dynamics Tunnel to demonstrate two morphing concepts and their enabling technologies with large-scale semi-span models. This paper will focus upon one of those wind tunnel tests that utilized a model developed by Lockheed Martin Aeronautics Company (LM). Wind tunnel success criteria were developed by NASA to support the DARPA program objectives. The primary focus of this paper will be the demonstration of the DARPA objectives by systematic evaluation of the wind tunnel model performance relative to the defined success criteria. This paper will also provide a description of the LM model and instrumentation, and document pertinent lessons learned. Finally, as part of the success criteria, aeroelastic characteristics of the LM derived MAS vehicle are also addressed. Evaluation of aeroelastic characteristics is the most detailed criterion investigated in this paper. While no aeroelastic instabilities were encountered as a direct result of the morphing design or components, several interesting and unexpected aeroelastic phenomenon arose during testing.

Iteratively Developing an mHealth HIV Prevention Program for Sexual Minority Adolescent Men

PubMed Central

Prescott, Tonya L.; Philips, Gregory L.; Bull, Sheana S.; Parsons, Jeffrey T.; Mustanski, Brian

2015-01-01

Five activities were implemented between November 2012 and June 2014 to develop an mHealth HIV prevention program for adolescent gay, bisexual, and queer men (AGBM): (1) focus groups to gather acceptability of the program components; (2) ongoing development of content; (3) Content Advisory Teams to confirm the tone, flow, and understandability of program content; (4) an internal team test to alpha test software functionality; and (5) a beta test to test the protocol and intervention messages. Findings suggest that AGBM preferred positive and friendly content that at the same time, did not try to sound like a peer. They deemed the number of daily text messages (i.e., 8–15 per day) to be acceptable. The Text Buddy component was well received but youth needed concrete direction about appropriate discussion topics. AGBM determined the self-safety assessment also was acceptable. Its feasible implementation in the beta test suggests that AGBM can actively self-determine their potential danger when participating in sexual health programs. Partnering with the target population in intervention development is critical to ensure that a salient final product and feasible protocol are created. PMID:26238038

Testing light concentrators prototypes for the Cherenkov Telescope Array

NASA Astrophysics Data System (ADS)

Hénault, François; Petrucci, Pierre-Olivier; Jocou, Laurent; Arezki, Brahim; Magnard, Yves; Khélifi, Bruno; Manigot, Pascal; Olive, Jean-François; Jean, Pierre; Punch, Michael

2017-09-01

With more than 30 Medium-Size Telescopes (MST) located in both North and South hemispheres, the Cherenkov Telescope Array (CTA) shall be the largest cosmic gamma ray detector ever built. Each MST focal plane consists in an array of some 1800 photomultipliers equipped with their own light concentrating optics in order to maximizing the amount of Cherenkov radiation collected by the telescope and to block stray light originating from ground environment. Within the CTA Consortium, the Institut de Planétologie et d'Astrophysique de Grenoble (IPAG) is in charge of designing, subcontracting the realization to industry, and testing the MST light concentrators. Two different optical solutions were pre-selected, respectively based on CPCs (Winston cones) and non-imaging concentrating lenses. Prototypes were manufactured by different industrial companies and tested in our laboratory on a test bench specifically built for the project. After shortly describing both optical designs, this communication is essentially focused at experimental results. Each type of concentrator has been submitted to extensive performance measurements, including radiometric efficiency at different wavelengths, rejection curves, and qualitative shape error test. The final selected concentrator is the CPC, although non-imaging lenses exhibit interesting properties in terms of radiometric performance.

60-MW test using the 30-MW klystrons for the KEKB project

NASA Astrophysics Data System (ADS)

Fukuda, S.; Michizono, S.; Nakao, K.; Saito, Y.; Anami, S.

1995-07-01

The B-Factory is a future plan, requiring an energy upgrade of the KEK linac from 2.5 GeV to 8.0 GeV (KEKB Project). This paper describes the recent development of an S-band high-power pulse klystron to be used as the PF-linac rf-source of the B-Factory. This tube is a modified version of the existing 30-MW tube, which produces 51 MW at a 310 kV beam voltage by optimizing the focusing magnetic field. In order to increase the reliability, the cathode diameter, the gun housing, and the insulation ceramic-seal were enlarged. This tube was redesigned so as to have the same characteristics as the test results of 30-MW tubes at a higher applied voltage without changing the rf interaction region. Four prototype tubes have been manufactured; final test results showed that these new tubes produce an output power of more than 50 MW at 310 kV with an efficiency of 46%. Recently this tube has produced more than 60 MW at a 350 kV beam voltage for a demonstration test. A comparison between the FCI-code prediction and the test results is also given in this paper.

Development strategies for the satellite flight software on-board Meteosat Third Generation

NASA Astrophysics Data System (ADS)

Tipaldi, Massimo; Legendre, Cedric; Koopmann, Olliver; Ferraguto, Massimo; Wenker, Ralf; D'Angelo, Gianni

2018-04-01

Nowadays, satellites are becoming increasingly software dependent. Satellite Flight Software (FSW), that is to say, the application software running on the satellite main On-Board Computer (OBC), plays a relevant role in implementing complex space mission requirements. In this paper, we examine relevant technical approaches and programmatic strategies adopted for the development of the Meteosat Third Generation Satellite (MTG) FSW. To begin with, we present its layered model-based architecture, and the means for ensuring a robust and reliable interaction among the FSW components. Then, we focus on the selection of an effective software development life cycle model. In particular, by combining plan-driven and agile approaches, we can fulfill the need of having preliminary SW versions. They can be used for the elicitation of complex system-level requirements as well as for the initial satellite integration and testing activities. Another important aspect can be identified in the testing activities. Indeed, very demanding quality requirements have to be fulfilled in satellite SW applications. This manuscript proposes a test automation framework, which uses an XML-based test procedure language independent of the underlying test environment. Finally, a short overview of the MTG FSW sizing and timing budgets concludes the paper.

Genetic testing in cardiovascular diseases.

PubMed

Arndt, Anne-Karin; MacRae, Calum A

2014-05-01

The review is designed to outline the major developments in genetic testing in the cardiovascular arena in the past year or so. This is an exciting time in genetic testing as whole exome and whole genome approaches finally reach the clinic. These new approaches offer insight into disease causation in families in which this might previously have been inaccessible, and also bring a wide range of interpretative challenges. Among the most significant recent findings has been the extent of physiologic rare coding variation in the human genome. New disease genes have been identified through whole exome studies in neonatal arrhythmia, congenital heart disease and coronary artery disease that were simply inaccessible with other techniques. This has not only shed light on the challenges of genetic testing at this scale, but has also sharply defined the limits of prior gene-panel focused testing. As novel therapies targeting specific genetic subsets of disease become available, genetic testing will become a part of routine clinical care. The pace of change in sequencing technologies has begun to transform clinical medicine, and cardiovascular disease is no exception. The complexity of such studies emphasizes the importance of real-time communication between the genetics laboratory and genetically informed clinicians. New efforts in data and knowledge management will be central to the continued advancement of genetic testing.

The window of opportunity: decision theory and the timing of prognostic tests for newborn infants.

PubMed

Wilkinson, Dominic

2009-11-01

In many forms of severe acute brain injury there is an early phase when prognosis is uncertain, followed later by physiological recovery and the possibility of more certain predictions of future impairment. There may be a window of opportunity for withdrawal of life support early, but if decisions are delayed there is the risk that the patient will survive with severe impairment. In this paper I focus on the example of neonatal encephalopathy and the question of the timing of prognostic tests and decisions to continue or to withdraw life-sustaining treatment. Should testing be performed early or later; and how should parents decide what to do given the conflicting values at stake? I apply decision theory to the problem, using sensitivity analysis to assess how different features of the tests or different values would affect a decision to perform early or late prognostic testing. I draw some general conclusions from this model for decisions about the timing of testing in neonatal encephalopathy. Finally I consider possible solutions to the problem posed by the window of opportunity. Decision theory highlights the costs of uncertainty. This may prompt further research into improving prognostic tests. But it may also prompt us to reconsider our current attitudes towards the palliative care of newborn infants predicted to be severely impaired.

Preliminary Test Results of Heshe Hydrogeological Experimental Well Station in Taiwan

NASA Astrophysics Data System (ADS)

Chuang, P.; Liu, C.; Lin, M.; Chan, W.; Lee, T.; Chia, Y.; Teng, M.; Liu, C.

2013-12-01

Safe disposal of radioactive waste is a critical issue for the development of nuclear energy. The design of final disposal system is based on the concept of multiple barriers which integrate the natural barriers and engineering barriers for long-term isolation of radioactive wastes. As groundwater is the major medium that can transport radionuclides to our living environment, it is essential to characterize groundwater flow at the disposal site. Taiwan is located at the boundary between the Eurasian plate and the Philippine Sea plate. Geologic formations are often fractured due to tectonic compression and extension. In this study, a well station for the research and development of hydrogeological techniques was established at the Experimental Forest of the National Taiwan University in central Taiwan. There are 10 testing wells, ranging in depth from 25 m to 100 m, at the station. The bedrock beneath the regolith is highly fractured mudstone. As fracture is the preferential pathway of the groundwater flow, the focus of in-situ tests is to investigate the location of permeable fractures and the connection of permeable fractures. Several field tests have been conducted, including geophysical logging, heat-pulse flowmeter, hydraulic test, tracer test and double packer test, for the development of advanced technologies to detect the preferential groundwater flow in fractured rocks.

DNA testing in homicide investigations.

PubMed

Prahlow, Joseph A; Cameron, Thomas; Arendt, Alexander; Cornelis, Kenneth; Bontrager, Anthony; Suth, Michael S; Black, Lisa; Tobey, Rebbecca; Pollock, Sharon; Stur, Shawn; Cotter, Kenneth; Gabrielse, Joel

2017-10-01

Objectives With the widespread use of DNA testing, police, death investigators, and attorneys need to be aware of the capabilities of this technology. This review provides an overview of scenarios where DNA evidence has played a major role in homicide investigations in order to highlight important educational issues for police, death investigators, forensic pathologists, and attorneys. Methods This was a nonrandom, observational, retrospective study. Data were obtained from the collective files of the authors from casework during a 15-year period, from 2000 through 2014. Results A series of nine scenarios, encompassing 11 deaths, is presented from the standpoint of the police and death investigation, the forensic pathology autopsy performance, the subsequent DNA testing of evidence, and, ultimately, the final adjudication of cases. Details of each case are presented, along with a discussion that focuses on important aspects of sample collection for potential DNA testing, especially at the crime scene and the autopsy. The presentation highlights the diversity of case and evidence types in which DNA testing played a valuable role in the successful prosecution of the case. Conclusions By highlighting homicides where DNA testing contributed to the successful adjudication of cases, police, death investigators, forensic pathologists, and attorneys will be better informed regarding the types of evidence and situations where such testing is of potential value.

Manufacturing process for the WEAVE prime focus corrector optics for the 4.2m William Hershel Telescope

NASA Astrophysics Data System (ADS)

Lhomé, Emilie; Agócs, Tibor; Abrams, Don Carlos; Dee, Kevin M.; Middleton, Kevin F.; Tosh, Ian A.; Jaskó, Attila; Connor, Peter; Cochrane, Dave; Gers, Luke; Jonas, Graeme; Rakich, Andrew; Benn, Chris R.; Balcells, Marc; Trager, Scott C.; Dalton, Gavin B.; Carrasco, Esperanza; Vallenari, Antonella; Bonifacio, Piercarlo; Aguerri, J. Alfonso L.

2016-07-01

In this paper, we detail the manufacturing process for the lenses that will constitute the new two-degree field-of-view Prime Focus Corrector (PFC) for the 4.2m William Herschel Telescope (WHT) optimised for the upcoming WEAVE Multi-Object Spectroscopy (MOS) facility. The corrector, including an Atmospheric Dispersion Corrector (ADC), is made of six large lenses, the largest being 1.1-meter diameter. We describe how the prescriptions of the optical design were translated into manufacturing specifications for the blanks and lenses. We explain how the as-built glass blank parameters were fed back into the optical design and how the specifications for the lenses were subsequently modified. We review the critical issues for the challenging manufacturing process and discuss the trade-offs that were necessary to deliver the lenses while maintaining the optimal optical performance. A short description of the lens optical testing is also presented. Finally, the subsequent manufacturing steps, including assembly, integration, and alignment are outlined.

Fundamental(ist) attribution error: Protestants are dispositionally focused.

PubMed

Li, Yexin Jessica; Johnson, Kathryn A; Cohen, Adam B; Williams, Melissa J; Knowles, Eric D; Chen, Zhansheng

2012-02-01

Attribution theory has long enjoyed a prominent role in social psychological research, yet religious influences on attribution have not been well studied. We theorized and tested the hypothesis that Protestants would endorse internal attributions to a greater extent than would Catholics, because Protestantism focuses on the inward condition of the soul. In Study 1, Protestants made more internal, but not external, attributions than did Catholics. This effect survived controlling for Protestant work ethic, need for structure, and intrinsic and extrinsic religiosity. Study 2 showed that the Protestant-Catholic difference in internal attributions was significantly mediated by Protestants' greater belief in a soul. In Study 3, priming religion increased belief in a soul for Protestants but not for Catholics. Finally, Study 4 found that experimentally strengthening belief in a soul increased dispositional attributions among Protestants but did not change situational attributions. These studies expand the understanding of cultural differences in attributions by demonstrating a distinct effect of religion on dispositional attributions.

Is recursion language-specific? Evidence of recursive mechanisms in the structure of intentional action.

PubMed

Vicari, Giuseppe; Adenzato, Mauro

2014-05-01

In their 2002 seminal paper Hauser, Chomsky and Fitch hypothesize that recursion is the only human-specific and language-specific mechanism of the faculty of language. While debate focused primarily on the meaning of recursion in the hypothesis and on the human-specific and syntax-specific character of recursion, the present work focuses on the claim that recursion is language-specific. We argue that there are recursive structures in the domain of motor intentionality by way of extending John R. Searle's analysis of intentional action. We then discuss evidence from cognitive science and neuroscience supporting the claim that motor-intentional recursion is language-independent and suggest some explanatory hypotheses: (1) linguistic recursion is embodied in sensory-motor processing; (2) linguistic and motor-intentional recursions are distinct and mutually independent mechanisms. Finally, we propose some reflections about the epistemic status of HCF as presenting an empirically falsifiable hypothesis, and on the possibility of testing recursion in different cognitive domains. Copyright © 2014 Elsevier Inc. All rights reserved.

Translating Research into Clinical Scale Manufacturing of Mesenchymal Stromal Cells

PubMed Central

Bieback, Karen; Kinzebach, Sven; Karagianni, Marianna

2010-01-01

It sounds simple to obtain sufficient numbers of cells derived from fetal or adult human tissues, isolate and/or expand the stem cells, and then transplant an appropriate number of these cells into the patient at the correct location. However, translating basic research into routine therapies is a complex multistep process which necessitates product regulation. The challenge relates to managing the expected therapeutic benefits with the potential risks and to balance the fast move to clinical trials with time-consuming cautious risk assessment. This paper will focus on the definition of mesenchymal stromal cells (MSCs), and challenges and achievements in the manufacturing process enabling their use in clinical studies. It will allude to different cellular sources, special capacities of MSCs, but also to current regulations, with a special focus on accessory material of human or animal origin, like media supplements. As cellular integrity and purity, formulation and lot release testing of the final product, validation of all procedures, and quality assurance are of utmost necessity, these topics will be addressed. PMID:21318154

Collaborative Mother-Toddler Communication and Theory of Mind Development at Age 4

PubMed Central

Sung, Jihyun; Hsu, Hui-Chin

2014-01-01

Focusing on social pragmatics, this longitudinal study investigated the contribution of mother-toddler collaborative communication to theory of mind (ToM) development at age 4. At age 2½, 78 toddlers’ (42 boys) and their mothers were observed during pretend play. At age 4, children were tested using 4 false belief understanding tasks. Both mothers and toddlers engaged in more collaborative (inform, guide/request, and support/confirm) than non-collaborative communication acts. Other-focused collaborative acts of support/confirm by mothers and toddlers predicted children’s false belief understanding, even after controlling for 5 covariates. In addition, as active agents in their own ToM development, the contribution of toddlers’ collaborative acts to false belief understanding was independent of their mothers. Finally, the way toddlers and their mothers co-constructing their communication mattered. Only when toddlers engaged in high levels of collaborative acts, the mothers’ high levels of collaborative acts demonstrated a positive effect on children’s ToM development. The applied implications of these findings were discussed. PMID:25132699

Outcomes of anatomical vs. functional testing for coronary artery disease : Lessons from the PROMISE trial.

PubMed

Shah, R; Foldyna, B; Hoffmann, U

2016-08-01

The development of coronary artery disease (CAD) is a major, final common pathway in heart disease worldwide. With a rise in stress testing and increased scrutiny on cost-effectiveness and radiation exposure in medical imaging, a focus on the relative merits of anatomic versus functional characterization of CAD has emerged. In this context, coronary computed tomography angiography (CCTA) is a noninvasive alternative to functional testing as a first-line test for CAD detection but is complimentary in its nature. Here, we discuss the design, results, and implications of the PROMISE trial, a randomized comparative effectiveness study of 10,003 patients across 193 sites in the United States and Canada comparing the prognostic and diagnostic power of CCTA and standard stress testing. Specifically, we discuss the safety (e. g., contrast, radiation exposure) of CCTA versus functional testing in CAD, the need for improved selection for noninvasive testing, the frequency of downstream testing after anatomic or functional imaging, the use of imaging results in clinical management, and novel modalities of CAD risk determination using CCTA. PROMISE demonstrated that in a real-world, low-to-intermediate risk patient population referred to noninvasive testing for CAD, both CCTA and functional testing approaches have similar clinical, economic, and safety-based outcomes. We conclude with open questions in CAD imaging, specifically as they pertain to the utilization of CCTA.

Successful Completion of the JWST OGSE2 Cryogenic Test at JSC Chamber-A While Managing Numerous Challenges

NASA Technical Reports Server (NTRS)

Park, Sang C.; Brinckerhoff, Pamela; Franck, Randy; Schweickart, Rusty; Thomson, Shaun; Burt, Bill; Ousley, Wes

2016-01-01

The James Webb Space Telescope (JWST) Optical Telescope Element (OTE) assembly is the largest optically stable infrared-optimized telescope currently being manufactured and assembled, and scheduled for launch in 2018. The JWST OTE, including the primary mirrors, secondary mirror, and the Aft Optics Subsystems (AOS) are designed to be passively cooled and operate at near 45 degrees Kelvin. Due to the size of its large sunshield in relation to existing test facilities, JWST cannot be optically or thermally tested as a complete observatory-level system at flight temperatures. As a result, the telescope portion along with its instrument complement will be tested as a single unit very late in the program, and on the program schedule critical path. To mitigate schedule risks, a set of 'pathfinder' cryogenic tests will be performed to reduce program risks by demonstrating the optical testing capabilities of the facility, characterizing telescope thermal performance, and allowing project personnel to learn valuable testing lessons off-line. This paper describes the 'pathfinder' cryogenic test program, focusing on the recently completed second test in the series called the Optical Ground Support Equipment 2 (OGSE2) test. The JWST OGSE2 was successfully completed within the allocated project schedule while faced with numerous conflicting thermal requirements during cool-down to the final cryogenic operational temperatures, and during warm-up after the cryo-stable optical tests. The challenges include developing a pre-test cool-down and warm-up profiles without a reliable method to predict the thermal behaviors in a rarified helium environment, and managing the test article hardware safety driven by the project Limits and Constraints (L&C's). Furthermore, OGSE2 test included the time critical Aft Optics Subsystem (AOS), a part of the flight Optical Telescope Element that would need to be placed back in the overall telescope assembly integrations. The OGSE2 test requirements included the strict adherence of the project contamination controls due to the presence of the contamination sensitive flight optical elements. The test operations required close coordination of numerous personnel while they being exposed and trained for the 'final' combined OTE and instrument cryo-test in 2017. This paper will also encompass the OGSE2 thermal data look-back review.

Antidepressant-like effects of erythropoietin: a focus on behavioural and hippocampal processes.

PubMed

Osborn, Meagan; Rustom, Nazneen; Clarke, Melanie; Litteljohn, Darcy; Rudyk, Chris; Anisman, Hymie; Hayley, Shawn

2013-01-01

Depression is a chronic and debilitating condition with a significant degree of relapse and treatment resistance that could stem, at least in part, from disturbances of neuroplasticity. This has led to an increased focus on treatment strategies that target brain derived neurotrophic factor (BDNF), synaptic plasticity and adult neurogenesis. In the current study we aimed to assess whether erythropoietin (EPO) would have antidepressant-like effects given its already established pro-trophic actions. In particular, we assessed whether EPO would diminish the deleterious effects of a social stressor in mice. Indeed, EPO induced anxiolytic and antidepressant-like responses in a forced swim test, open field, elevated-plus maze, and a novelty test, and appeared to blunt some of the negative behavioural effects of a social stressor. Furthermore, EPO promoted adult hippocampal neurogenesis, an important feature of effective antidepressants. Finally, a separate study using the mTOR inhibitor rapamycin revealed that antagonizing this pathway prevented the impact of EPO upon forced swim performance. These data are consistent with previous findings showing that the mTOR pathway and its neurogenic and synaptogenic effects might mediate the behavioral consequences of antidepressant agents. Our findings further highlight EPO as a possible adjunct treatment for affective disorders, as well as other stressor associated disorders of impaired neuroplasticity.

At, with and beyond risk: expectations of living with the possibility of future dementia.

PubMed

Milne, Richard; Diaz, Ana; Badger, Shirlene; Bunnik, Eline; Fauria, Karine; Wells, Katie

2018-04-16

Biomedical research aimed at the development of therapies for chronic and late-onset conditions increasingly concentrates on the early treatment of symptom-less disease. This broad trend is evidenced in prominent shifts in contemporary dementia research. Revised diagnostic criteria and new approaches to clinical trials propose a focus on earlier stages of disease and prompt concerns about the implications of communicating test results associated with the risk of developing dementia when no effective treatments are available. This article examines expectations of the implications of learning test results related to dementia risk, based on focus group research conducted in the UK and Spain. It points to the extended social and temporal aspects of the dementia risk experience. Three key dimensions of this risk experience are elaborated: living 'at risk', represented in efforts to reduce risk and plan for the future; 'with risk', through vigilance towards cognitive health and earlier or prolonged contact with healthcare services; and finally, 'beyond risk' through a cessation of the self in its current social, legal and financial form. A virtual abstract of this paper can be viewed at: https://www.youtube.com/channel/UC_979cmCmR9rLrKuD7z0ycA. © 2018 Foundation for the Sociology of Health & Illness.

Pancreatitis Quality of Life Instrument: Development of a new instrument

PubMed Central

Bova, Carol; Barton, Bruce; Hartigan, Celia

2014-01-01

Objectives: The goal of this project was to develop the first disease-specific instrument for the evaluation of quality of life in chronic pancreatitis. Methods: Focus groups and interview sessions were conducted, with chronic pancreatitis patients, to identify items felt to impact quality of life which were subsequently formatted into a paper-and-pencil instrument. This instrument was used to conduct an online survey by an expert panel of pancreatologists to evaluate its content validity. Finally, the modified instrument was presented to patients during precognitive testing interviews to evaluate its clarity and appropriateness. Results: In total, 10 patients were enrolled in the focus groups and interview sessions where they identified 50 items. Once redundant items were removed, the 40 remaining items were made into a paper-and-pencil instrument referred to as the Pancreatitis Quality of Life Instrument. Through the processes of content validation and precognitive testing, the number of items in the instrument was reduced to 24. Conclusions: This marks the development of the first disease-specific instrument to evaluate quality of life in chronic pancreatitis. It includes unique features not found in generic instruments (economic factors, stigma, and spiritual factors). Although this marks a giant step forward, psychometric evaluation is still needed prior to its clinical use. PMID:26770703

Granularity refined by knowledge: contingency tables and rough sets as tools of discovery

NASA Astrophysics Data System (ADS)

Zytkow, Jan M.

2000-04-01

Contingency tables represent data in a granular way and are a well-established tool for inductive generalization of knowledge from data. We show that the basic concepts of rough sets, such as concept approximation, indiscernibility, and reduct can be expressed in the language of contingency tables. We further demonstrate the relevance to rough sets theory of additional probabilistic information available in contingency tables and in particular of statistical tests of significance and predictive strength applied to contingency tables. Tests of both type can help the evaluation mechanisms used in inductive generalization based on rough sets. Granularity of attributes can be improved in feedback with knowledge discovered in data. We demonstrate how 49er's facilities for (1) contingency table refinement, for (2) column and row grouping based on correspondence analysis, and (3) the search for equivalence relations between attributes improve both granularization of attributes and the quality of knowledge. Finally we demonstrate the limitations of knowledge viewed as concept approximation, which is the focus of rough sets. Transcending that focus and reorienting towards the predictive knowledge and towards the related distinction between possible and impossible (or statistically improbable) situations will be very useful in expanding the rough sets approach to more expressive forms of knowledge.

Current Interruption and Particle Beam Generation by a Plasma Focus.

DTIC Science & Technology

1982-11-30

Through collaboration with Dr. K. H. Schoenbach of Texas Tech University the plasma focus opening switch (PFOS) was revised to answer basic questions...results are consistent with the snowplow model. The final analysis of the plasma focus particle beam generation experiments was completed and a...strong correlation was found for the beam-target model as the mechanism for neutron production in the Illinois plasma focus device. (Author)

[Recurrent vulvovaginitis: diagnostic assessment and therapeutic management].

PubMed

Ramírez-Santos, A; Pereiro, M; Toribio, J

2008-04-01

Recurrent vulvovaginitis is a common problem in clinical practice. Management is often complicated by a long history of inappropriate treatments based on tentative diagnoses after an incomplete diagnostic workup. We review the most common causes of recurrent vulvovaginitis; the appropriate steps with which to establish a diagnosis, from the medical history through to the additional tests needed; and, finally, the best therapeutic options. We will focus on infectious, irritant, allergic, and hormonal causes as the ones of most interest to the dermatologist. Given that infection is the most frequent cause of these processes and also a common reason for inopportune treatment, we will pay particular attention to infectious etiologies and their differential diagnosis.

A Motivational Theory of Life-Span Development

PubMed Central

Heckhausen, Jutta; Wrosch, Carsten; Schulz, Richard

2010-01-01

This article had four goals. First, the authors identified a set of general challenges and questions that a life-span theory of development should address. Second, they presented a comprehensive account of their Motivational Theory of Life-Span Development. They integrated the model of optimization in primary and secondary control and the action-phase model of developmental regulation with their original life-span theory of control to present a comprehensive theory of development. Third, they reviewed the relevant empirical literature testing key propositions of the Motivational Theory of Life-Span Development. Finally, because the conceptual reach of their theory goes far beyond the current empirical base, they pointed out areas that deserve further and more focused empirical inquiry. PMID:20063963

Statistics for Radiology Research.

PubMed

Obuchowski, Nancy A; Subhas, Naveen; Polster, Joshua

2017-02-01

Biostatistics is an essential component in most original research studies in imaging. In this article we discuss five key statistical concepts for study design and analyses in modern imaging research: statistical hypothesis testing, particularly focusing on noninferiority studies; imaging outcomes especially when there is no reference standard; dealing with the multiplicity problem without spending all your study power; relevance of confidence intervals in reporting and interpreting study results; and finally tools for assessing quantitative imaging biomarkers. These concepts are presented first as examples of conversations between investigator and biostatistician, and then more detailed discussions of the statistical concepts follow. Three skeletal radiology examples are used to illustrate the concepts. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Hypochondriacal Concerns: Management Through Understanding

PubMed Central

Holder-Perkins, Vicenzio; Wise, Thomas N.; Williams, Darren E.

2000-01-01

The medically unexplained complaint is often a symptom of hypochondriacal concerns. Patients with hypochondriasis may be managed with either naive realism or consideration of morbid categorization or via dimensional assessment of illness beliefs and behaviors. Naive realism will foster focus somatization and promote regression as well as lead to needless tests and treatments. Attention to categorical entities such a major depression or anxiety disorders will alert the clinician to comorbid psychiatric disorders that respond to traditional psychiatric treatments. Finally, by assessing the domains of illness behaviors such as disease conviction, beliefs in organic versus psychological causes, and denial, the clinician can document and then confront abnormal cognitive schema that revolve around somatic concerns that are a proxy for psychosocial difficulties. PMID:15014644

Creating new futures in nursing education: envisioning the evolution of e-nursing education.

PubMed

Neuman, Lois H

2006-01-01

This article discusses the explosion of technology and its impact on nursing education in the face of a nurse educator shortage. An attempt is made to answer the following questions:What incremental changes in technology do we have now? How do we envision technology being used in the future? Four scenarios of nontraditional approaches to nursing education are presented. They touch on the delivery of education with increased technology and universal access; the teacher as educator/mentor/coach; the product, including testing, outcomes, competencies, and process; and attracting and keeping human attention. The final section focuses on issues to consider as nurse leaders and educators bring nursing education into the future.

On recent advances and future research directions for computational fluid dynamics

NASA Technical Reports Server (NTRS)

Baker, A. J.; Soliman, M. O.; Manhardt, P. D.

1986-01-01

This paper highlights some recent accomplishments regarding CFD numerical algorithm constructions for generation of discrete approximate solutions to classes of Reynolds-averaged Navier-Stokes equations. Following an overview of turbulent closure modeling, and development of appropriate conservation law systems, a Taylor weak-statement semi-discrete approximate solution algorithm is developed. Various forms for completion to the final linear algebra statement are cited, as are a range of candidate numerical linear algebra solution procedures. This development sequence emphasizes the key building blocks of a CFD RNS algorithm, including solution trial and test spaces, integration procedure and added numerical stability mechanisms. A range of numerical results are discussed focusing on key topics guiding future research directions.

Further clarifying proximal withdrawal states and the turnover criterion space: Comment on Hom, Mitchell, Lee, and Griffeth (2012).

PubMed

Maertz, Carl P

2012-09-01

In "Reviewing Employee Turnover: Focusing on Proximal Withdrawal States and an Expanded Criterion," Hom, Mitchell, Lee, and Griffeth (2012) brought together many of the most important content and process factors in the employee turnover literature. In this paper, I attempt to clarify the true contributions of this framework for the turnover area and at the same time explain why improved prediction is not among these contributions. I then enumerate 3 theoretically problematic aspects of the proposed framework, which limit its contribution. Finally, I suggest 3 directions that researchers should pursue in order to test and extend the framework. (PsycINFO Database Record (c) 2012 APA, all rights reserved).

Quantum healing of spacetime singularities: A review

NASA Astrophysics Data System (ADS)

Konkowski, D. A.; Helliwell, T. M.

2018-02-01

Singularities are commonplace in general relativistic spacetimes. It is natural to hope that they might be “healed” (or resolved) by the inclusion of quantum mechanics, either in the theory itself (quantum gravity) or, more modestly, in the description of the spacetime geodesic paths used to define them. We focus here on the latter, mainly using a procedure proposed by Horowitz and Marolf to test whether singularities in broad classes of spacetimes can be resolved by replacing geodesic paths with quantum wave packets. We list the spacetime singularities that various authors have studied in this context, and distinguish those which are healed quantum mechanically (QM) from those which remain singular. Finally, we mention some alternative approaches to healing singularities.

Urogynecologic Surgical Mesh Implants

MedlinePlus

... FDA collected samples during the inspections, and reviewed mechanical performance testing and sterility testing of the final ... characterization of the polypropylene resin, and biocompatibility and mechanical performance testing on the final product. The FDA ...

Motivation of restraint system usage among specific target groups of drivers and passengers

DOT National Transportation Integrated Search

1983-07-14

Thirty focus groups were conducted in seven different cities. These focus groups were used to determine potentially effective motivational approaches, develop appropriate themes and general content of messages and, finally, to identify corresponding ...

Smaller Footprint Drilling System for Deep and Hard Rock Environments; Feasibility of Ultra-High-Speed Diamond Drilling

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arnis Judzis; Homer Robertson; Alan Black

2006-06-22

The two phase program addresses long-term developments in deep well and hard rock drilling. TerraTek believes that significant improvements in drilling deep hard rock will be obtained by applying ultra-high rotational speeds (greater than 10,000 rpm). The work includes a feasibility of concept research effort aimed at development that will ultimately result in the ability to reliably drill ''faster and deeper'' possibly with smaller, more mobile rigs. The principle focus is on demonstration testing of diamond bits rotating at speeds in excess of 10,000 rpm to achieve high rate of penetration (ROP) rock cutting with substantially lower inputs of energymore » and loads. The significance of the ''ultra-high rotary speed drilling system'' is the ability to drill into rock at very low weights on bit and possibly lower energy levels. The drilling and coring industry today does not practice this technology. The highest rotary speed systems in oil field and mining drilling and coring today run less than 10,000 rpm-usually well below 5,000 rpm. This document details the progress at the end of Phase 1 on the program entitled ''Smaller Footprint Drilling System for Deep and Hard Rock Environments: Feasibility of Ultra-High-Speed Diamond Drilling'' for the period starting 1 March 2006 and concluding 30 June 2006. (Note: Results from 1 September 2005 through 28 February 2006 were included in the previous report (see Judzis, Black, and Robertson)). Summarizing the accomplished during Phase 1: {lg_bullet} TerraTek reviewed applicable literature and documentation and convened a project kickoff meeting with Industry Advisors in attendance (see Black and Judzis). {lg_bullet} TerraTek designed and planned Phase I bench scale experiments (See Black and Judzis). Some difficulties continued in obtaining ultra-high speed motors. Improvements were made to the loading mechanism and the rotational speed monitoring instrumentation. New drill bit designs were developed to provided a more consistent product with consistent performance. A test matrix for the final core bit testing program was completed. {lg_bullet} TerraTek concluded Task 3 ''Small-scale cutting performance tests.'' {sm_bullet} Significant testing was performed on nine different rocks. {sm_bullet} Five rocks were used for the final testing. The final tests were based on statistical design of experiments. {sm_bullet} Two full-faced bits, a small diameter and a large diameter, were run in Berea sandstone. {lg_bullet} Analysis of data was completed and indicates that there is decreased specific energy as the rotational speed increases (Task 4). Data analysis from early trials was used to direct the efforts of the final testing for Phase I (Task 5). {lg_bullet} Technology transfer (Task 6) was accomplished with technical presentations to the industry (see Judzis, Boucher, McCammon, and Black).« less

76 FR 65631 - Energy Conservation Program: Test Procedures for Microwave Ovens

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-24

... Conservation Program: Test Procedures for Microwave Ovens AGENCY: Office of Energy Efficiency and Renewable... (DOE) has initiated a test procedure rulemaking to develop active mode testing methodologies for... Federal Register a final rule for the microwave oven test procedure rulemaking (July TP repeal final rule...

2-Mercaptobenzothiazole; Final Test Rule

EPA Pesticide Factsheets

EPA is issuing a final test rule, under section 4 of the Toxic Substances Control Act (TSCA) requiring manufacturers and processors of 2-mercaptobenzothiazole (MBT, CAS No. 149—30-4) to perform testing.

Focusing Resources on Effective School Health: A FRESH Start to Enhancing the Quality and Equity of Education. World Education Forum 2000. Final Report = Accorder la priorite a un programme efficace de sante scolaire: Une maniere FRAICHE (FRESH) d'aneliorer la qualite et d'accroitre l'equite dans le domaine de l'education. Forum mondial 2000 sur l'education. Rapport final = Recursos efectivos en salud escolar: Un enfogue NUEVO para mejorar la calidad y la equidad educativa. Foro Mundial par la educacion 2000. Informe final.

ERIC Educational Resources Information Center

United Nations Educational, Scientific, and Cultural Organization, Paris (France).

This booklet, written in English, Spanish, and French, describes the foundation and reasoning behind the partnership to Focus on Resources on Effective School Health (FRESH), making the case that an effective school health program: responds to the greater number of school-age children and the greater proportion of those children attending school;…

40 CFR 90.709 - Calculation and reporting of test results.

Code of Federal Regulations, 2014 CFR

2014-07-01

... expressed to one additional significant figure. (b) Final test results are calculated by summing the initial... applicable standard expressed to one additional significant figure. (c) The final deteriorated test results...

40 CFR 90.709 - Calculation and reporting of test results.

Code of Federal Regulations, 2011 CFR

2011-07-01

... expressed to one additional significant figure. (b) Final test results are calculated by summing the initial... applicable standard expressed to one additional significant figure. (c) The final deteriorated test results...

Federal Register notice: Isopropanol; Final Test Rule

EPA Pesticide Factsheets

EPA is issuing a final test rule, under section 4 of the Toxic Substances Control Act (TSCA), requiring manufacturers and processors of isopropanol (CAS No. 87-83-0) to perform testing for health effects.

2-Ethylhexanoic Acid; Final Test Rule

EPA Pesticide Factsheets

EPA is issuing a final test rule, under section 4 of the Toxic Substances Control Act (TSCA), requiring manufacturers and processors of 2-ethylhexanoic acid (EHA, CAS No. 149-57-5) to conduct testing.

Toxic Substances; Mesityl Oxide; Final Test Rule

EPA Pesticide Factsheets

EPA is issuing a final test rule establishing testing requirements under section 4(a) of the Toxic Substances Control Act (TSCA) for manufacturers and processors of mesityl oxide (MO; CAS No. 141-97-7).

Hazardous material transportation safety and security field operational test final detailed test plans : executive summary

DOT National Transportation Integrated Search

2003-09-16

The objective of this Hazardous Material (HazMat) Transportation Safety and Security Field Operational Test (FOT) Final Detailed Test Plans evaluation is to measure the impact of technology solutions on the safety, security, and operational efficienc...

The WEAVE focus translation system: from design to construction

NASA Astrophysics Data System (ADS)

Canchado, Manuel; Romero, Antonio; Maroto, Óscar; Tomas, Albert; Martín-Nuño, Carlos; Casalta, Joan Manel; Prida, Joaquín.; L. Aguerri, J. Alfonso; Herreros, José Miguel; Delgado, José Miguel; Burgal, José Alonso; Abrams, Don Carlos; Dee, Kevin; Dalton, Gavin; Bonifacio, Piercarlo; Trager, Scott C.; Vallenari, Antonella

2016-07-01

WEAVE is a new wide-field spectroscopy facility proposed for the prime focus of the 4.2m William Herschel Telescope (WHT), placed in La Palma, Canary Islands, Spain. To allow for the compensation of the effects of temperature-induced and gravity-induced image degradation, the WEAVE prime focus assembly will be translated along the telescope optical axis. The assembly comprises the prime focus corrector with integrated ADC, a central mount for the corrector, an instrument rotator and a twin-focal-plane fibre positioner. Translation is accomplished through the use of a set of purpose-built actuators; collectively referred to as the Focus Translation System (FTS), formed by four independently-controlled Focus Translation Units (FTUs), eight vanes connecting the FTUs to a central can, and a central can hosting WEAVE Instrument. Each FTU is capable of providing a maximum stroke of +/-4mm with sufficient, combined force to move the five-tonne assembly with a positional accuracy of +/-20μm at a resolution of 5μm. The coordinated movement of the four FTUs allows +/-3mm WEAVE focus adjustment in the optical axis and +/-0.015° tilt correction in one axis. The control of the FTS is accomplished through a PLC-based subsystem that receives positional demands from the higher-level Instrument Control System. SENER has been responsible for designing, manufacturing and testing the FTS and the equipment required to manipulate and store the FTS together with the instrument. This manuscript describes the final design of the FTS along with the analyses and simulations that were performed, discusses the manufacturing procedures and the results of early verification prior to integration with the telescope. The plans for mounting the whole system on the telescope are also discussed.

A high resolution hand-held focused beam profiler

NASA Astrophysics Data System (ADS)

Zapata-Farfan, J.; Garduño-Mejía, J.; Rosete-Aguilar, M.; Ascanio, G.; Román-Moreno, C. J.

2017-05-01

The shape of a beam is important in any laser application and depending on the final implementation, there exists a preferred one which is defined by the irradiance distribution.1 The energy distribution (or laser beam profile) is an important parameter in a focused beam, for instance, in laser cut industry, where the beam shape determines the quality of the cut. In terms of alignment and focusing, the energy distribution also plays an important role since the system must be configured in order to reduce the aberration effects and achieve the highest intensity. Nowadays a beam profiler is used in both industry and research laboratories with the aim to characterize laser beams used in free-space communications, focusing and welding, among other systems. The purpose of the profile analyzers is to know the main parameters of the beam, to control its characteristics as uniformity, shape and beam size as a guide to align the focusing system. In this work is presented a high resolution hand-held and compact design of a beam profiler capable to measure at the focal plane, with covered range from 400 nm to 1000 nm. The detection is reached with a CMOS sensor sized in 3673.6 μm x 2738.4 μm which acquire a snap shot of the previously attenuated focused beam to avoid the sensor damage, the result is an image of beam intensity distribution, which is digitally processed with a RaspberryTMmodule gathering significant parameters such as beam waist, centroid, uniformity and also some aberrations. The profiler resolution is 1.4 μm and was probed and validated in three different focusing systems. The spot sizes measurements were compared with the Foucault knife-edge test.

The Calibration System of the E989 Experiment at Fermilab

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anastasi, Antonio

The muon anomaly aµ is one of the most precise quantity known in physics experimentally and theoretically. The high level of accuracy permits to use the measurement of aµ as a test of the Standard Model comparing with the theoretical calculation. After the impressive result obtained at Brookhaven National Laboratory in 2001 with a total accuracy of 0.54 ppm, a new experiment E989 is under construction at Fermilab, motivated by the diff of aexp SM µ - aµ ~ 3σ. The purpose of the E989 experiment is a fourfold reduction of the error, with a goal of 0.14 ppm,more » improving both the systematic and statistical uncertainty. With the use of the Fermilab beam complex a statistic of × 21 with respect to BNL will be reached in almost 2 years of data taking improving the statistical uncertainty to 0.1 ppm. Improvement on the systematic error involves the measurement technique of ωa and ωp, the anomalous precession frequency of the muon and the Larmor precession frequency of the proton respectively. The measurement of ωp involves the magnetic field measurement and improvements on this sector related to the uniformity of the field should reduce the systematic uncertainty with respect to BNL from 170 ppb to 70 ppb. A reduction from 180 ppb to 70 ppb is also required for the measurement of ωa; new DAQ, a faster electronics and new detectors and calibration system will be implemented with respect to E821 to reach this goal. In particular the laser calibration system will reduce the systematic error due to gain fl of the photodetectors from 0.12 to 0.02 ppm. The 0.02 ppm limit on systematic requires a system with a stability of 10 -4 on short time scale (700 µs) while on longer time scale the stability is at the percent level. The 10 -4 stability level required is almost an order of magnitude better than the existing laser calibration system in particle physics, making the calibration system a very challenging item. In addition to the high level of stability a particular environment, due to the presence of a 14 m diameter storage ring, a highly uniform magnetic field and the detector distribution around the storage ring, set specific guidelines and constraints. This thesis will focus on the final design of the Laser Calibration System developed for the E989 experiment. Chapter 1 introduces the subject of the anomalous magnetic moment of the muon; chapter 2 presents previous measurement of g -2, while chapter 3 discusses the Standard Model prediction and possible new physics scenario. Chapter 4 describes the E989 experiment. In this chapter will be described the experimental technique and also will be presented the experimental apparatus focusing on the improvements necessary to reduce the statistical and systematic errors. The main item of the thesis is discussed in the last two chapters: chapter 5 is focused on the Laser Calibration system while chapter 6 describes the Test Beam performed at the Beam Test Facility of Laboratori Nazionali di Frascati from the 29th February to the 7th March as a final test for the full calibrations system. An introduction explain the physics motivation of the system and the diff t devices implemented. In the final chapter the setup used will be described and some of the results obtained will be presented.« less

Assessing Chronic Illness Care Education (ACIC-E): a tool for tracking educational re-design for improving chronic care education.

PubMed

Bowen, Judith L; Provost, Lloyd; Stevens, David P; Johnson, Julie K; Woods, Donna M; Sixta, Connie S; Wagner, Edward H

2010-09-01

Recent Breakthrough Series Collaboratives have focused on improving chronic illness care, but few have included academic practices, and none have specifically targeted residency education in parallel with improving clinical care. Tools are available for assessing progress with clinical improvements, but no similar instruments have been developed for monitoring educational improvements for chronic care education. To design a survey to assist teaching practices with identifying curricular gaps in chronic care education and monitor efforts to address those gaps. During a national academic chronic care collaborative, we used an iterative method to develop and pilot test a survey instrument modeled after the Assessing Chronic Illness Care (ACIC). We implemented this instrument, the ACIC-Education, in a second collaborative and assessed the relationship of survey results with reported educational measures. A combined 57 self-selected teams from 37 teaching hospitals enrolled in one of two collaboratives. We used descriptive statistics to report mean ACIC-E scores and educational measurement results, and Pearson's test for correlation between the final ACIC-E score and reported educational measures. A total of 29 teams from the national collaborative and 15 teams from the second collaborative in California completed the final ACIC-E. The instrument measured progress on all sub-scales of the Chronic Care Model. Fourteen California teams (70%) reported using two to six education measures (mean 4.3). The relationship between the final survey results and the number of educational measures reported was weak (R(2) = 0.06, p = 0.376), but improved when a single outlier was removed (R(2) = 0.37, p = 0.022). The ACIC-E instrument proved feasible to complete. Participating teams, on average, recorded modest improvement in all areas measured by the instrument over the duration of the collaboratives. The relationship between the final ACIC-E score and the number of educational measures was weak. Further research on its utility and validity is required.

Development and Validation of an Acid Mine Drainage Treatment Process for Source Water

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lane, Ann

Throughout Northern Appalachia and surrounding regions, hundreds of abandoned mine sites exist which frequently are the source of Acid Mine Drainage (AMD). AMD typically contains metal ions in solution with sulfate ions which have been leached from the mine. These large volumes of water, if treated to a minimum standard, may be of use in Hydraulic Fracturing (HF) or other industrial processes. This project’s focus is to evaluate an AMD water treatment technology for the purpose of providing treated AMD as an alternative source of water for HF operations. The HydroFlex™ technology allows the conversion of a previous environmental liabilitymore » into an asset while reducing stress on potable water sources. The technology achieves greater than 95% water recovery, while removing sulfate to concentrations below 100 mg/L and common metals (e.g., iron and aluminum) below 1 mg/L. The project is intended to demonstrate the capability of the process to provide AMD as alternative source water for HF operations. The second budget period of the project has been completed during which Battelle conducted two individual test campaigns in the field. The first test campaign demonstrated the ability of the HydroFlex system to remove sulfate to levels below 100 mg/L, meeting the requirements indicated by industry stakeholders for use of the treated AMD as source water. The second test campaign consisted of a series of focused confirmatory tests aimed at gathering additional data to refine the economic projections for the process. Throughout the project, regular communications were held with a group of project stakeholders to ensure alignment of the project objectives with industry requirements. Finally, the process byproduct generated by the HydroFlex process was evaluated for the treatment of produced water against commercial treatment chemicals. It was found that the process byproduct achieved similar results for produced water treatment as the chemicals currently in use. Further, the process byproduct demonstrated better settling characteristics in bench scale testing. The field testing conducted in the second project budget period demonstrated the ability of the HydroFlex technology to meet industry requirements for AMD water chemical composition so that it can be used as source water in HF activities. System and operational improvements were identified in an additional series of confirmatory tests to achieve competitive cost targets. Finally, the application of the HydroFlex process byproduct in produced water treatment was demonstrated, further supporting the commercial implementation of the technology. Overall, the project results demonstrate a path to the economic treatment of AMD to support its increased use as source water in HF, particularly in regions with limited local freshwater availability.« less

Validation of artificial skin equivalents as in vitro testing systems

NASA Astrophysics Data System (ADS)

Schmitt, Robert; Marx, Ulrich; Walles, Heike; Schober, Lena

2011-03-01

With the increasing complexity of the chemical composition of pharmaceuticals, cosmetics and everyday substances, the awareness of potential health issues and long term damages for humanoid organs is shifting into focus. Artificial in vitro testing systems play an important role in providing reliable test conditions and replacing precarious animal testing. Especially artificial skin equivalents ASEs are used for a broad spectrum of studies like penetration, irritation and corrosion of substances. One major challenge in tissue engineering is the qualification of each individual ASE as in vitro testing system. Due to biological fluctuations, the stratum corneum hornified layer of some ASEs may not fully develop or other defects might occur. For monitoring these effects we developed an fully automated Optical Coherence Tomography device. Here, we present different methods to characterize and evaluate the quality of the ASEs based on image and data processing of OCT B-scans. By analysing the surface structure, defects, like cuts or tears, are detectable. A further indicator for the quality of the ASE is the morphology of the tissue. This allows to determine if the skin model has reached the final growth state. We found, that OCT is a well suited technology for automatically characterizing artificial skin equivalents and validating the application as testing system.

European Respiratory Society guidelines for the diagnosis of primary ciliary dyskinesia.

PubMed

Lucas, Jane S; Barbato, Angelo; Collins, Samuel A; Goutaki, Myrofora; Behan, Laura; Caudri, Daan; Dell, Sharon; Eber, Ernst; Escudier, Estelle; Hirst, Robert A; Hogg, Claire; Jorissen, Mark; Latzin, Philipp; Legendre, Marie; Leigh, Margaret W; Midulla, Fabio; Nielsen, Kim G; Omran, Heymut; Papon, Jean-Francois; Pohunek, Petr; Redfern, Beatrice; Rigau, David; Rindlisbacher, Bernhard; Santamaria, Francesca; Shoemark, Amelia; Snijders, Deborah; Tonia, Thomy; Titieni, Andrea; Walker, Woolf T; Werner, Claudius; Bush, Andrew; Kuehni, Claudia E

2017-01-01

The diagnosis of primary ciliary dyskinesia is often confirmed with standard, albeit complex and expensive, tests. In many cases, however, the diagnosis remains difficult despite the array of sophisticated diagnostic tests. There is no "gold standard" reference test. Hence, a Task Force supported by the European Respiratory Society has developed this guideline to provide evidence-based recommendations on diagnostic testing, especially in light of new developments in such tests, and the need for robust diagnoses of patients who might enter randomised controlled trials of treatments. The guideline is based on pre-defined questions relevant for clinical care, a systematic review of the literature, and assessment of the evidence using the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach. It focuses on clinical presentation, nasal nitric oxide, analysis of ciliary beat frequency and pattern by high-speed video-microscopy analysis, transmission electron microscopy, genotyping and immunofluorescence. It then used a modified Delphi survey to develop an algorithm for the use of diagnostic tests to definitively confirm and exclude the diagnosis of primary ciliary dyskinesia; and to provide advice when the diagnosis was not conclusive. Finally, this guideline proposes a set of quality criteria for future research on the validity of diagnostic methods for primary ciliary dyskinesia. Copyright ©ERS 2017.

Biosuccinic Acid from Lignocellulosic-Based Hexoses and Pentoses by Actinobacillus succinogenes: Characterization of the Conversion Process.

PubMed

Ferone, Mariateresa; Raganati, Francesca; Olivieri, Giuseppe; Salatino, Piero; Marzocchella, Antonio

2017-12-01

Succinic acid (SA) is a well-established chemical building block. Actinobacillus succinogenes fermentation is by far the most investigated route due to very promising high SA yield and titer on several sugars. This study contributes to include the SA production within the concept of biorefinery of lignocellulose biomass. The study was focused on the SA production by A. succinogenes DSM 22257 using sugars representative from lignocellulose hydrolysis-glucose, mannose, arabinose, and xylose-as carbon source. Single sugar batch fermentation tests and mixture sugar fermentation tests were carried out. All the sugars investigated were converted in succinic acid by A. succinogenes. The best fermentation performances were measured in tests with glucose as carbon source. The bacterial growth kinetics was characterized by glucose inhibition. No inhibition phenomena were observed with the other sugar investigated. The sugar mixture fermentation tests highlighted the synergic effects of the co-presence of the four sugars. Under the operating conditions tested, the final concentration of succinic acid in the sugar mixture test was larger (27 g/L) than that expected (25.5 g/L) by combining the fermentation of the single sugar. Moreover, the concentration of acetic and formic acid was lower, consequently obtaining an increment in the succinic acid specificity.

Experience, Knowledge, and Opinions about Childhood Genetic Testing in Batten Disease

PubMed Central

Rose, Katherine; Augustine, Erika F.; Kwon, Jennifer M.; deBlieck, Elisabeth A.; Marshall, Frederick J.; Vierhile, Amy; Mink, Jonathan W.; Nance, Martha A.

2013-01-01

Background and Objectives Policies for genetic testing in children (GTIC) focus on medical or psychosocial benefit to the child, discouraging or prohibiting carrier testing, and advising caution regarding pre-symptomatic diagnosis if no treatment exists. This study sought to understand parents’ perspectives on these issues and determine their experiences and knowledge related to genetic testing for Batten disease – a set of inherited neurodegenerative diseases of childhood onset for which no disease modifying therapies yet exist. Methods Parents of children with Batten disease completed a survey of their knowledge of genetics, experience with genetic testing, and opinions regarding GTIC. Results 54% had sought genetic testing for non-affected family members, including predictive diagnosis of healthy, at-risk children. Participation in any genetic counseling was associated with greater knowledge on questions about genetics. The majority of parents felt it was better to know ahead of time that a child would develop Batten disease, believed that this knowledge would not alter how they related to their child, and that parents should have the final say in deciding whether to obtain GTIC. Conclusions Parents of children with an inherited disease are knowledgeable about genetics and wish to establish predictive or carrier status of at-risk children. PMID:24246680

Optimization of an Optical Test Bench for Tire Properties Measurement and Tread Defects Characterization

PubMed Central

Castillo Aguilar, Juan Jesús; Cabrera Carrillo, Juan Antonio; Guerra Fernández, Antonio Jesús; Postigo Pozo, Sergio

2017-01-01

Tire characteristics and behavior are of great importance in vehicle dynamics since the forces transmitted in the tire-road contact are the main contributors to global vehicle performance. Several research groups have focused on the study and modeling of tires. Some of the most important factors that need to be known are tread characteristics and pressure distribution in the tire-ground contact patch. In this work, a test bench has been used to adequately determine the aforementioned factors. The measurement principle of the test bench is the frustration of total internal reflection (FTIR) of light. It makes use of a laterally illuminated glass on which the tire leans. An interposed plastic interface between them causes the reflection of light. Finally, a video camera captures the bright image formed through the glass. The brightness level in each pixel of the image is related to existing normal pressure. A study of the parameters that affect the test bench calibration such as type of interface material used, diffuse light, hysteresis, creep and transverse light absorption is performed. Experimental tests are conducted to relate tire inflation pressure and camber angle to the pressure distribution. Furthermore, the test bench is used to detect and evaluate the influence of defects in the tire on the contact pressures. PMID:28353674

Optimization of an Optical Test Bench for Tire Properties Measurement and Tread Defects Characterization.

PubMed

Castillo Aguilar, Juan Jesús; Cabrera Carrillo, Juan Antonio; Guerra Fernández, Antonio Jesús; Postigo Pozo, Sergio

2017-03-29

Tire characteristics and behavior are of great importance in vehicle dynamics since the forces transmitted in the tire-road contact are the main contributors to global vehicle performance. Several research groups have focused on the study and modeling of tires. Some of the most important factors that need to be known are tread characteristics and pressure distribution in the tire-ground contact patch. In this work, a test bench has been used to adequately determine the aforementioned factors. The measurement principle of the test bench is the frustration of total internal reflection (FTIR) of light. It makes use of a laterally illuminated glass on which the tire leans. An interposed plastic interface between them causes the reflection of light. Finally, a video camera captures the bright image formed through the glass. The brightness level in each pixel of the image is related to existing normal pressure. A study of the parameters that affect the test bench calibration such as type of interface material used, diffuse light, hysteresis, creep and transverse light absorption is performed. Experimental tests are conducted to relate tire inflation pressure and camber angle to the pressure distribution. Furthermore, the test bench is used to detect and evaluate the influence of defects in the tire on the contact pressures.

KSC-2014-4520

NASA Image and Video Library

2014-11-19

CAPE CANAVERAL, Fla. –NASA's Project Morpheus prototype lander undergoes final preparations for a tethered-flight test at the north end of the Shuttle Landing Facility at NASA’s Kennedy Space Center in Florida. For the 40-second test, the lander will be hoisted 20 feet. The spacecraft will ascend an additional five feet and hover for five seconds. Morpheus then will perform a 5.6-foot ascent coupled with a 9.8-foot traverse, and hover for five more seconds before returning to the launch point. A number of changes have been made, primarily focused on autonomous landing and hazard avoidance technology ALHAT and moving the Doppler Lidar to the front of the forward liquid oxygen tank. The tether test was cut short due to Morpheus exceeding onboard abort rate limits. The vehicle was taken back to the hangar and data from the test is being studied. After review, managers will determine when a new test date will be set. The landing facility provides the lander with the kind of field necessary for realistic testing, complete with rocks, craters and hazards to avoid. Morpheus’ ALHAT payload allows it to navigate to clear landing sites amidst rocks, craters and other hazards during its descent. For more information on Project Morpheus, visit http://morpheuslander.jsc.nasa.gov/. Photo credit: NASA/Kim Shiflett

Retrieval enhances eyewitness suggestibility to misinformation in free and cued recall.

PubMed

Wilford, Miko M; Chan, Jason C K; Tuhn, Sam J

2014-03-01

Immediately recalling a witnessed event can increase people's susceptibility to later postevent misinformation. But this retrieval-enhanced suggestibility (RES) effect has been shown only when the initial recall test included specific questions that reappeared on the final test. Moreover, it is unclear whether this phenomenon is affected by the centrality of event details. These limitations make it difficult to generalize RES to criminal investigations, which often begin with free recall prior to more specific queries from legal officials and attorneys. In 3 experiments, we examined the influence of test formats (free recall vs. cued recall) and centrality of event details (central vs. peripheral) on RES. In Experiment 1, both the initial and final tests were cued recall. In Experiment 2, the initial test was free recall and the final test was cued recall. In Experiment 3, both the initial and final tests were free recall. Initial testing increased misinformation reporting on the final test for peripheral details in all experiments, but the effect was significant for central details only after aggregating the data from all 3 experiments. These results show that initial free recall can produce RES, and more broadly, that free recall can potentiate subsequent learning of complex prose materials. © 2013 American Psychological Association

High performance low cost interconnections for flip chip attachment with electrically conductive adhesive. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1998-05-01

This final report is a compilation of final reports from each of the groups participating in the program. The main three groups involved in this effort are the Thomas J. Watson Research Center of IBM Corporation in Yorktown Heights, New York, Assembly Process Design of IBM Corporation in Endicott, New York, and SMT Laboratory of Universal Instruments Corporation in Binghamton, New York. The group at the research center focused on the conductive adhesive materials development and characterization. The group in process development focused on processing of the Polymer-Metal-Solvent Paste (PMSP) to form conductive adhesive bumps, formation of the Polymer-Metal Compositemore » (PMC) on semiconductor devices and study of the bonding process to circuitized organic carriers, and the long term durability and reliability of joints formed using the process. The group at Universal Instruments focused on development of an equipment set and bonding parameters for the equipment to produce bond assembly tooling. Reports of each of these individual groups are presented here reviewing their technical efforts and achievements.« less

Final Report: Self-Consolidating Concrete Construction for Modular Units

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gentry, Russell; Kahn, Lawrence; Kurtis, Kimberly

This report focuses on work completed on DE-NE0000667, Self-Consolidating Concrete for Modular Units, in connection with the Department of Energy Nuclear Energy Enabling Technologies (DOE-NEET) program. This project was completed in the School of Civil and Environmental Engineering at the Georgia Institute of Technology, with Westinghouse Corporation as the industrial partner. The primary objective of this project was to develop self-consolidating concrete (also termed “self-compacting concrete” or SCC) mixtures so that concrete placement can be made into steel plate composite (SC) modular structures without the need for continuous concrete placement. As part of the research, SCC mixtures were developed andmore » validated to ensure sufficient shear capacity across cold-joints, while minimizing shrinkage and temperature increase during curing to enhance concrete bonding with the steel plate construction found in modular units. The SCC mixtures developed were able to carry shearing forces across the cold-joint boundaries. This “self-roughening” was achieved by adding a tailored fraction of lightweight aggregate (LWA) to the concrete mix, some of which raised to the surface during curing, forming a rough surface on which subsequent concrete placements were made. The self-roughening behavior was validated through three sets of structural tests. Shear friction on small-scale specimens with cold joints was assessed using varying fractions of LWA and with varying amounts of external steel plate reinforcement. The results show that the shear friction coefficient, to be used with the provisions of ACI 318-14, Section 22.9, can be taken as 1.35. Mid-scale beam tests were completed to assess the cold-joint capacity in both in-plane and out-of-plane bending. The results showed that the self-roughened joints performed as well as monolithic joints. The final assessment was a full-scale test using a steel composite module supplied by Westinghouse and similar in construction to the steel composite modules being assembled at the Vogtle and V.C. Summer plant expansions. The final test showed that the roughened cold-joint showed excellent shear and flexural capacity, and substantial ductility, when used in conjunction with steel composite construction.« less

Application of Regulatory Focus Theory to Search Advertising.

PubMed

Mowle, Elyse N; Georgia, Emily J; Doss, Brian D; Updegraff, John A

The purpose of this paper is to test the utility of regulatory focus theory principles in a real-world setting; specifically, Internet hosted text advertisements. Effect of compatibility of the ad text with the regulatory focus of the consumer was examined. Advertisements were created using Google AdWords. Data were collected for the number of views and clicks each ad received. Effect of regulatory fit was measured using logistic regression. Logistic regression analyses demonstrated that there was a strong main effect for keyword, such that users were almost six times as likely to click on a promotion advertisement as a prevention advertisement, as well as a main effect for compatibility, such that users were twice as likely to click on an advertisement with content that was consistent with their keyword. Finally, there was a strong interaction of these two variables, such that the effect of consistent advertisements was stronger for promotion searches than for prevention searches. The effect of ad compatibility had medium to large effect sizes, suggesting that individuals' state may have more influence on advertising response than do individuals' traits (e.g. personality traits). Measurement of regulatory fit was limited by the constraints of Google AdWords. The results of this study provide a possible framework for ad creation for Internet advertisers. This paper is the first study to demonstrate the utility of regulatory focus theory in online advertising.

MEMS scanner with 2D tilt, piston, and focus motion

NASA Astrophysics Data System (ADS)

Lani, S.; Bayat, D.; Petremand, Y.; Regamey, Y.-J.; Onillon, E.; Pierer, J.; Grossmann, S.

2017-02-01

A MEMS scanner with a high level of motion freedom has been developed. It includes a 2D mechanical tilting capability of +/- 15°, a piston motion of 50μm and a focus/defocus control system of a 2mm diameter mirror. The tilt and piston motion is achieved with an electromagnetic actuation (moving magnet) and the focus control with a deformation of the reflective surface with pneumatic actuation. This required the fabrication of at least one channel on the compliant membrane and a closed cavity below the mirror surface and connected to an external pressure regulator (vacuum to several bars). The fabrication relies on 3 SOI wafers, 2 for forming the compliant membranes and the integrated channel, and 1 to form the cavity mirror. All wafers were then assembled by fusion bonding. Pneumatic actuation for focus control can be achieved from front or back side; function of packaging concept. A reflective coating can be added at the mirror surface depending of the application. The tilt and piston actuation is achieved by electromagnetic actuation for which a magnet is fixed on the moving part of the MEMS device. Finally the MEMS device is mounted on a ceramic PCB, containing the actuation micro-coils. Concept, fabrication, and testing of the devices will be presented. A case study for application in an endoscope with an integrated high power laser and a MEMS steering mechanism will be presented.

Methyl Ethyl Ketoxime; Final Test Rule

EPA Pesticide Factsheets

EPA is issuing this final test rule under section 4 of the Toxic Substances Control Act (TSCA), requiring manufacturers and processors of methyl ethyl ketoxime (MEKO, CAS No. 96-29-7) to perform testing for health effects.

Evaluating safety and operation of high-speed signalized intersections : final report, March 2010.

DOT National Transportation Integrated Search

2010-03-01

This Final Report reviews a research effort to evaluate the safety and operations of high-speed intersections in the State of : Oregon. In particular, this research effort focuses on four-leg, signalized intersections with speed limits of 45 mph or :...

Baselining current road weather information : results of the 2010 quality and importance survey final report.

DOT National Transportation Integrated Search

2011-01-30

This final report contains research findings on the characterization of the quality and value of road weather information resources used by members of the surface transportation community in their decision-making process. This report focuses on the r...

77 FR 9625 - Presentation of Final Conventional Conformance Test Criteria and Common Air Interface (CAI...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-17

... Tests for Inclusion in the Program AGENCY: National Institute of Standards and Technology (NIST... meeting is to present the final requirements for CAI conventional conformance tests for inclusion in the... suitability for inclusion in the P25 CAP is below: Conformance tests should limit devices in the test...

Focused ion beam system

DOEpatents

Leung, Ka-Ngo; Gough, Richard A.; Ji, Qing; Lee, Yung-Hee Yvette

1999-01-01

A focused ion beam (FIB) system produces a final beam spot size down to 0.1 .mu.m or less and an ion beam output current on the order of microamps. The FIB system increases ion source brightness by properly configuring the first (plasma) and second (extraction) electrodes. The first electrode is configured to have a high aperture diameter to electrode thickness aspect ratio. Additional accelerator and focusing electrodes are used to produce the final beam. As few as five electrodes can be used, providing a very compact FIB system with a length down to only 20 mm. Multibeamlet arrangements with a single ion source can be produced to increase throughput. The FIB system can be used for nanolithography and doping applications for fabrication of semiconductor devices with minimum feature sizes of 0.1 .mu.m or less.

Focused ion beam system

DOEpatents

Leung, K.; Gough, R.A.; Ji, Q.; Lee, Y.Y.

1999-08-31

A focused ion beam (FIB) system produces a final beam spot size down to 0.1 {mu}m or less and an ion beam output current on the order of microamps. The FIB system increases ion source brightness by properly configuring the first (plasma) and second (extraction) electrodes. The first electrode is configured to have a high aperture diameter to electrode thickness aspect ratio. Additional accelerator and focusing electrodes are used to produce the final beam. As few as five electrodes can be used, providing a very compact FIB system with a length down to only 20 mm. Multibeamlet arrangements with a single ion source can be produced to increase throughput. The FIB system can be used for nanolithography and doping applications for fabrication of semiconductor devices with minimum feature sizes of 0.1 m or less. 13 figs.

For My Children: Mexican American Women, Work, and Welfare. Focus Study Report #2.

ERIC Educational Resources Information Center

Quiroz, Julia Teresa; Tosca, Regina

This is the final report of the National Council of La Raza's (NCLR) Focus Study examining the opinions, attitudes, and needs of Mexican American single women, relating to implementation of national welfare reform legislation. Over a 2-year period NCLR staff held focus groups with Mexican American women in four communities: Phoenix, Arizona; Mora,…

Impacts of the FOCUS Act on Governance in Tennessee Higher Education Institutions

ERIC Educational Resources Information Center

Barber, Jennifer H.; Chesley, Colin G.; Flora, Bethany H.

2016-01-01

With the final passage of the Focus on College and University Success (FOCUS) Act which was signed into law on April 19, 2016, state universities within Tennessee are heading for major transitions in governance structure and autonomy. With changes moving at a speed atypical of higher education, these six soon-to-be former Tennessee Board of…

Numerical study of influence of hydrogen backflow on krypton Hall effect thruster plasma focusing

NASA Astrophysics Data System (ADS)

Yan, Shilin; Ding, Yongjie; Wei, Liqiu; Hu, Yanlin; Li, Jie; Ning, Zhongxi; Yu, Daren

2017-03-01

The influence of backflow hydrogen on plasma plume focusing of a krypton Hall effect thruster is studied via a numerical simulation method. Theoretical analysis indicates that hydrogen participates in the plasma discharge process, changes the potential and ionization distribution in the thruster discharge cavity, and finally affects the plume focusing within a vacuum vessel.

The knowledge attitude and practice regarding diabetes and diabetic retinopathy among the final year medical students of King Faisal University Medical College of Al Hasa region of Saudi Arabia: a cross sectional survey.

PubMed

Al Wadaani, F A

2013-01-01

The purpose of the study was to assess the knowledge attitude and practice of the final year medical students of king faisal university medical college towards diabetes and diabetic retinopathy. A cross sectional survey was conducted in King Faisal university Medical college of Al Hasa province of Saudi Arabia in May 2012. The student population was the Final Year students of MBBS. All 96 students of final year MBBS were included in this study. The data were collected by means of filling up of pre-tested specially designed questionnaires focused on Knowledge, Attitude and practice towards Diabetes Mellitus and Diabetic retinopathy. The answers were scored by assigning marks. A SPSS 17 was used for statistical analysis. The mean of overall KAP score (±SD) for all the respondents were 64.75 ± 11.17 (Maximum 100). Male students scored better than the females students (65.30, P = 0.02 vs. 64.18, P = 0.02). The male student scored better in the knowledge (35.83 vs. 34.05, P = 0.018) and practice (13.63 vs. 12.95, P = 0.045) category while the attitude score of female student (17.16 vs. 15.83, P = 0 .020) was significantly higher than the male students. The main weakness of knowledge was on epidemiology of Diabetes Mellitus (DM), the follow up of the diabetic patient for the screening of diabetic retinopathy and the relation of duration of diabetes with the development and progression of diabetic retinopathy. Many students believed that diabetes is more prevalent among the uneducated people. Ninety percent students did not know the proper angle of insulin injection. This survey highlights some of the lacuna in the teaching system of the medical students and identified the need for improvement in their knowledge, attitude and practices for treating the patients with diabetes and diabetic retinopathy. This can be done by incorporating special syllabus focusing on diabetes and diabetic retinopathy in their teaching programme.

NOAA Gulf Spill Restoration |

Science.gov Websites

Plan, Focusing on Recreational Use and Nutrient Reduction Louisiana Trustees Release Fourth Draft Restoration Plan, Focusing on Recreational Use and Nutrient Reduction Read More... Florida Trustee Implementation Group Releases Phase V.2 Final Restoration Plan Florida Trustee Implementation Group Releases

Nanomaterial Case Study: Nanoscale Silver in Disinfectant Spray (Final Report)

EPA Science Inventory

EPA announced the release of the final report, Nanomaterial Case Study: Nanoscale Silver in Disinfectant Spray. This report represents a case study of engineered nanoscale silver (nano-Ag), focusing on the specific example of nano-Ag as possibly used in disinfectant spr...

Kansas Early Childhood Research Institute on Transitions. Final Report.

ERIC Educational Resources Information Center

Rice, Mabel L.; O'Brien, Marion

This final report describes research projects and other activities of the Kansas Early Childhood Research Institute (KECRI), a multi-investigator, cross-disciplinary Institute focusing on successful transitions for young (birth to age 8) children with disabilities or developmental delays. Interventions were developed, evaluated, and disseminated…

Inertial particle focusing in serpentine channels on a centrifugal platform

NASA Astrophysics Data System (ADS)

Shamloo, Amir; Mashhadian, Ali

2018-01-01

Inertial particle focusing as a powerful passive method is widely used in diagnostic test devices. It is common to use a curved channel in this approach to achieve particle focusing through balancing of the secondary flow drag force and the inertial lift force. Here, we present a focusing device on a disk based on the interaction of secondary flow drag force, inertial lift force, and centrifugal forces to focus particles. By choosing a channel whose cross section has a low aspect ratio, the mixing effect of the secondary flow becomes negligible. To calculate inertial lift force, which is exerted on the particle from the fluid, the interaction between the fluid and particle is investigated accurately through implementation of 3D Direct Numerical Solution (DNS) method. The particle focusing in three serpentine channels with different corner angles of 75°, 85°, and 90° is investigated for three polystyrene particles with diameters of 8 μm, 9.9 μm, and 13 μm. To show the simulation reliability, the results obtained from the simulations of two examples, namely, particle focusing and centrifugal platform, are verified against experimental counterparts. The effects of angular velocity of disk on the fluid velocity and on the focusing parameters are studied. Fluid velocity in a channel with corner angle of 75° is greater than two other channels. Furthermore, the particle equilibrium positions at the cross section of channel are obtained at the outlet. There are two equilibrium positions located at the centers of the long walls. Finally, the effect of particle density on the focusing length is investigated. A particle with a higher density and larger diameter is focused in a shorter length of the channel compared to its counterpart with a lower density and shorter diameter. The channel with a corner angle of 90° has better focusing efficiency compared to other channels. This design focuses particles without using any pump or sheath flow. Inertial particle focusing on centrifugal platform, which rarely has been studied, can be used for a wide range of diagnostic lab-on-a-disk device.

9 CFR 113.110 - Clostridium Botulinum Type C Bacterin-Toxoid.

Code of Federal Regulations, 2012 CFR

2012-01-01

..., safety, and potency as prescribed in this section. A serial found unsatisfactory by any prescribed test shall not be released. (a) Purity test. Final container samples of completed product from each serial... test. Bulk or final container samples of completed product from each serial shall be tested for safety...

9 CFR 113.110 - Clostridium Botulinum Type C Bacterin-Toxoid.

Code of Federal Regulations, 2010 CFR

2010-01-01

..., safety, and potency as prescribed in this section. A serial found unsatisfactory by any prescribed test shall not be released. (a) Purity test. Final container samples of completed product from each serial... test. Bulk or final container samples of completed product from each serial shall be tested for safety...

Impact of the De-Alloying Kinetics and Alloy Microstructure on the Final Morphology of De-Alloyed Meso-Porous Metal Films

PubMed Central

Lin, Bao; Kong, Lingxue; Hodgson, Peter D.; Dumée, Ludovic F.

2014-01-01

Nano-textured porous metal materials present unique surface properties due to their enhanced surface energy with potential applications in sensing, molecular separation and catalysis. In this paper, commercial alloy foils, including brass (Cu85Zn15 and Cu70Zn30) and white gold (Au50Ag50) foils have been chemically de-alloyed to form nano-porous thin films. The impact of the initial alloy micro-structure and number of phases, as well as chemical de-alloying (DA) parameters, including etchant concentration, time and solution temperature on the final nano-porous thin film morphology and properties were investigated by electron microscopy (EM). Furthermore, the penetration depth of the pores across the alloys were evaluated through the preparation of cross sections by focus ion beam (FIB) milling. It is demonstrated that ordered pores ranging between 100 nm and 600 nm in diameter and 2–5 μm in depth can be successfully formed for the range of materials tested. The microstructure of the foils were obtained by electron back-scattered diffraction (EBSD) and linked to development of pits across the material thickness and surface during DA. The role of selective etching of both noble and sacrificial metal phases of the alloy were discussed in light of the competitive surface etching across the range of microstructures and materials tested. PMID:28344253

Multi-objects recognition for distributed intelligent sensor networks

NASA Astrophysics Data System (ADS)

He, Haibo; Chen, Sheng; Cao, Yuan; Desai, Sachi; Hohil, Myron E.

2008-04-01

This paper proposes an innovative approach for multi-objects recognition for homeland security and defense based intelligent sensor networks. Unlike the conventional way of information analysis, data mining in such networks is typically characterized with high information ambiguity/uncertainty, data redundancy, high dimensionality and real-time constrains. Furthermore, since a typical military based network normally includes multiple mobile sensor platforms, ground forces, fortified tanks, combat flights, and other resources, it is critical to develop intelligent data mining approaches to fuse different information resources to understand dynamic environments, to support decision making processes, and finally to achieve the goals. This paper aims to address these issues with a focus on multi-objects recognition. Instead of classifying a single object as in the traditional image classification problems, the proposed method can automatically learn multiple objectives simultaneously. Image segmentation techniques are used to identify the interesting regions in the field, which correspond to multiple objects such as soldiers or tanks. Since different objects will come with different feature sizes, we propose a feature scaling method to represent each object in the same number of dimensions. This is achieved by linear/nonlinear scaling and sampling techniques. Finally, support vector machine (SVM) based learning algorithms are developed to learn and build the associations for different objects, and such knowledge will be adaptively accumulated for objects recognition in the testing stage. We test the effectiveness of proposed method in different simulated military environments.

Dried Blood Spots - Preparing and Processing for Use in Immunoassays and in Molecular Techniques

PubMed Central

Grüner, Nico; Stambouli, Oumaima; Ross, R. Stefan

2015-01-01

The idea of collecting blood on a paper card and subsequently using the dried blood spots (DBS) for diagnostic purposes originated a century ago. Since then, DBS testing for decades has remained predominantly focused on the diagnosis of infectious diseases especially in resource-limited settings or the systematic screening of newborns for inherited metabolic disorders and only recently have a variety of new and innovative DBS applications begun to emerge. For many years, pre-analytical variables were only inappropriately considered in the field of DBS testing and even today, with the exception of newborn screening, the entire pre-analytical phase, which comprises the preparation and processing of DBS for their final analysis has not been standardized. Given this background, a comprehensive step-by-step protocol, which covers al the essential phases, is proposed, i.e., collection of blood; preparation of blood spots; drying of blood spots; storage and transportation of DBS; elution of DBS, and finally analyses of DBS eluates. The effectiveness of this protocol was first evaluated with 1,762 coupled serum/DBS pairs for detecting markers of hepatitis B virus, hepatitis C virus, and human immunodeficiency virus infections on an automated analytical platform. In a second step, the protocol was utilized during a pilot study, which was conducted on active drug users in the German cities of Berlin and Essen. PMID:25867233

Modeling DNA structure and processes through animation and kinesthetic visualizations

NASA Astrophysics Data System (ADS)

Hager, Christine

There have been many studies regarding the effectiveness of visual aids that go beyond that of static illustrations. Many of these have been concentrated on the effectiveness of visual aids such as animations and models or even non-traditional visual aid activities like role-playing activities. This study focuses on the effectiveness of three different types of visual aids: models, animation, and a role-playing activity. Students used a modeling kit made of Styrofoam balls and toothpicks to construct nucleotides and then bond nucleotides together to form DNA. Next, students created their own animation to depict the processes of DNA replication, transcription, and translation. Finally, students worked in teams to build proteins while acting out the process of translation. Students were given a pre- and post-test that measured their knowledge and comprehension of the four topics mentioned above. Results show that there was a significant gain in the post-test scores when compared to the pre-test scores. This indicates that the incorporated visual aids were effective methods for teaching DNA structure and processes.

Design and development of a radio frequency quadrupole linac postaccelerator for the Variable Energy Cyclotron Center rare ion beam project.

PubMed

Dechoudhury, S; Naik, V; Mondal, M; Chatterjee, A; Pandey, H K; Mandi, T K; Bandyopadhyay, A; Karmakar, P; Bhattacharjee, S; Chouhan, P S; Ali, S; Srivastava, S C L; Chakrabarti, A

2010-02-01

A four-rod type heavy-ion radio frequency quadrupole (RFQ) linac has been designed, constructed, and tested for the rare ion beam (RIB) facility project at VECC. Designed for cw operation, this RFQ is the first postaccelerator in the RIB beam line. It will accelerate A/q < or = 14 heavy ions coming from the ion source to the energy of around 100 keV/u for subsequent acceleration in a number of Interdigital H-Linac. Operating at a resonance frequency of 37.83 MHz, maximum intervane voltage of around 54 kV will be needed to achieve the final energy over a vane length of 3.12 m for a power loss of 35 kW. In the first beam tests, transmission efficiency of about 90% was measured at the QQ focus after the RFQ for O(5+) beam. In this article the design of the RFQ including the effect of vane modulation on the rf characteristics and results of beam tests will be presented.

Commognitive analysis of undergraduate mathematics students' first encounter with the subgroup test

NASA Astrophysics Data System (ADS)

Ioannou, Marios

2018-06-01

This study analyses learning aspects of undergraduate mathematics students' first encounter with the subgroup test, using the commognitive theoretical framework. It focuses on students' difficulties as these are related to the object-level and metalevel mathematical learning in group theory, and, when possible, highlights any commognitive conflicts. In the data analysis, one can identify three types of difficulties, relevant to object-level learning: namely regarding the frequently observed confusion between groups and sets, the object-level rules of visual mediators, and the object-level rules of contextual notions, such as permutations, exponentials, sets and matrices. In addition, data analysis suggests two types of difficulties, relevant to metalevel learning. The first refers to the actual proof that the three conditions of subgroup test hold, and the second is related to syntactic inaccuracies, incomplete argumentation and problematic use of visual mediators. Finally, this study suggests that there are clear links between object-level and metalevel learning, mainly due to the fact that objectification of the various relevant mathematical notions influences the endorsement of the governing metarules.

Would you hire me? Selfie portrait images perception in a recruitment context

NASA Astrophysics Data System (ADS)

Mazza, F.; Da Silva, M. P.; Le Callet, P.

2014-02-01

Human content perception has been underlined to be important in multimedia quality evaluation. Recently aesthetic considerations have been subject of research in this field. First attempts in aesthetics took into account perceived low-level features, especially taken from photography theory. However they demonstrated to be insuf- ficient to characterize human content perception. More recently image psychology started to be considered as higher cognitive feature impacting user perception. In this paper we follow this idea introducing social cognitive elements. Our experiments focus on the influence of different versions of portrait pictures in context where they are showed aside some completely unrelated informations; this can happen for example in social networks interactions between users, where profile pictures are present aside almost every user action. In particular, we tested this impact on resumes between professional portrait and self shot pictures. Moreover, as we run tests in crowdsourcing, we will discuss the use of this methodology for these tests. Our final aim is to analyse social biases' impact on multimedia aesthetics evaluation and how this bias influences messages that go along with pictures, as in public online platforms and social networks.

The design of an intelligent human-computer interface for the test, control and monitor system

NASA Technical Reports Server (NTRS)

Shoaff, William D.

1988-01-01

The graphical intelligence and assistance capabilities of a human-computer interface for the Test, Control, and Monitor System at Kennedy Space Center are explored. The report focuses on how a particular commercial off-the-shelf graphical software package, Data Views, can be used to produce tools that build widgets such as menus, text panels, graphs, icons, windows, and ultimately complete interfaces for monitoring data from an application; controlling an application by providing input data to it; and testing an application by both monitoring and controlling it. A complete set of tools for building interfaces is described in a manual for the TCMS toolkit. Simple tools create primitive widgets such as lines, rectangles and text strings. Intermediate level tools create pictographs from primitive widgets, and connect processes to either text strings or pictographs. Other tools create input objects; Data Views supports output objects directly, thus output objects are not considered. Finally, a set of utilities for executing, monitoring use, editing, and displaying the content of interfaces is included in the toolkit.

Testing Group Mean Differences of Latent Variables in Multilevel Data Using Multiple-Group Multilevel CFA and Multilevel MIMIC Modeling.

PubMed

Kim, Eun Sook; Cao, Chunhua

2015-01-01

Considering that group comparisons are common in social science, we examined two latent group mean testing methods when groups of interest were either at the between or within level of multilevel data: multiple-group multilevel confirmatory factor analysis (MG ML CFA) and multilevel multiple-indicators multiple-causes modeling (ML MIMIC). The performance of these methods were investigated through three Monte Carlo studies. In Studies 1 and 2, either factor variances or residual variances were manipulated to be heterogeneous between groups. In Study 3, which focused on within-level multiple-group analysis, six different model specifications were considered depending on how to model the intra-class group correlation (i.e., correlation between random effect factors for groups within cluster). The results of simulations generally supported the adequacy of MG ML CFA and ML MIMIC for multiple-group analysis with multilevel data. The two methods did not show any notable difference in the latent group mean testing across three studies. Finally, a demonstration with real data and guidelines in selecting an appropriate approach to multilevel multiple-group analysis are provided.

Data Concentrator

NASA Technical Reports Server (NTRS)

Willett, Mike

2015-01-01

Orbital Research, Inc., developed, built, and tested three high-temperature components for use in the design of a data concentrator module in distributed turbine engine control. The concentrator receives analog and digital signals related to turbine engine control and communicates with a full authority digital engine control (FADEC) or high-level command processor. This data concentrator follows the Distributed Engine Controls Working Group (DECWG) roadmap for turbine engine distributed controls communication development that operates at temperatures at least up to 225 C. In Phase I, Orbital Research developed detailed specifications for each component needed for the system and defined the total system specifications. This entailed a combination of system design, compiling existing component specifications, laboratory testing, and simulation. The results showed the feasibility of the data concentrator. Phase II of this project focused on three key objectives. The first objective was to update the data concentrator design modifications from DECWG and prime contractors. Secondly, the project defined requirements for the three new high-temperature, application-specific integrated circuits (ASICs): one-time programmable (OTP), transient voltage suppression (TVS), and 3.3V. Finally, the project validated each design by testing over temperature and under load.

Taiwanese antennas for the Sub-Millimeter Array: a progress report

NASA Astrophysics Data System (ADS)

Raffin, Phillippe A.; Liu, Ching-Tang; Cervera, Mathieu; Chang, Chi-Ling; Chen, Ming-Tang; Lee, Cheng-Ching; Lee, Typhoon; Lo, Kwok-Yung; Ma, Rwei-Ping; Martin, Robert N.; Martin-Cocher, Pierre; Ong, Ching-Long; Park, Yong-Sun; Tsai, Rong-Den; Wu, Enboa; Yang, Shun-Cheng; Yang, Tien-Szu

2000-07-01

The Academia Sinica, Institute for Astronomy and Astrophysics (ASIAA) is building two antennas to be added to the six antennas of the Sub-Millimeter Array (SMA) of the Smithsonian Astrophysical Observatory (SAO). The antennas have been designed at SAO and are currently under construction at Mauna Kea. ASIAA's two antennas are made in Taiwan from parts manufactured locally and imported from Europe and from the USA. This report will focus on the manufacturing and testing of 2 major components: the alidade and the reflector. We will emphasize the work done on the composite parts used in the 6- meter reflectors, namely the carbon fiber tubes for the backup structure, the carbon fiber legs of the quadrupod and the composite central hub. We will discuss the modal testing and pointing tests of the antennas. Finally this report will show how the Taiwanese industry was able to respond to the high manufacturing standards required to build sub-millimeter antennas. The design and manufacturing capabilities of the Aeronautical Research Laboratories and China Shipbuilding Corporation have made possible the construction of the telescopes in Taiwan.

Performance Testing of a Magnetically Suspended Double Gimbal Control Moment Gyro Based on the Single Axis Air Bearing Table

PubMed Central

Cui, Peiling; Zhang, Huijuan; Yan, Ning; Fang, Jiancheng

2012-01-01

Integrating the advantage of magnetic bearings with a double gimble control moment gyroscope (DGCMG), a magnetically suspended DGCMG (MSDGCMG) is an ideal actuator in high-precision, long life, and rapid maneuver attitude control systems. The work presented here mainly focuses on performance testing of a MSDGCMG independently developed by Beihang University, based on the single axis air bearing table. In this paper, taking into sufficient consideration to the moving-gimbal effects and the response bandwidth limit of the gimbal, a special MSDGCMG steering law is proposed subject to the limits of gimbal angle rate and angle acceleration. Finally, multiple experiments are carried out, with different MSDGCMG angular momenta as well as different desired attitude angles. The experimental results indicate that the MSDGCMG has a good gimbal angle rate and output torque tracking capabilities, and that the attitude stability with MSDGCMG as actuator is superior to 10−3°/s. The MSDGCMG performance testing in this paper, carried out under moving-base condition, will offer a technique base for the future research and application of MSDGCMGs. PMID:23012536

Near minimum-time maneuvers of the advanced space structures technology research experiment (ASTREX) test article: Theory and experiments

NASA Technical Reports Server (NTRS)

Vadali, Srinivas R.; Carter, Michael T.

1994-01-01

The Phillips Laboratory at the Edwards Air Force Base has developed the Advanced Space Structures Technology Research Experiment (ASTREX) facility to serve as a testbed for demonstrating the applicability of proven theories to the challenges of spacecraft maneuvers and structural control. This report describes the work performed on the ASTREX test article by Texas A&M University under contract NAS119373 as a part of the Control-Structure Interaction (CSI) Guest Investigator Program. The focus of this work is on maneuvering the ASTREX test article with compressed air thrusters that can be throttled, while attenuating structural excitation. The theoretical foundation for designing the near minimum-time thrust commands is based on the generation of smooth, parameterized optimal open-loop control profiles, and the determination of control laws for final position regulation and tracking using Lyapunov stability theory. Details of the theory, mathematical modeling, model updating, and compensation for the presence of 'real world' effects are described and the experimental results are presented. The results show an excellent match between theory and experiments.

Tetrabromobisphenol A; Final Test Rule

EPA Pesticide Factsheets

EPA is issuing a final test rule, under section 4 of the Toxic Substances Control Act (TSCA), requiring manufacturers and processors of tetrabromobisphenol A (TBBPA. CAS No. 79—94—7) to perform testing for chemical fate and environmental effects.

Gregorian optical system with non-linear optical technology for protection against intense optical transients

DOEpatents

Ackermann, Mark R [Albuquerque, NM; Diels, Jean-Claude M [Albuquerque, NM

2007-06-26

An optical system comprising a concave primary mirror reflects light through an intermediate focus to a secondary mirror. The secondary mirror re-focuses the image to a final image plane. Optical limiter material is placed near the intermediate focus to optically limit the intensity of light so that downstream components of the optical system are protected from intense optical transients. Additional lenses before and/or after the intermediate focus correct optical aberrations.

Dogs' Body Language Relevant to Learning Achievement.

PubMed

Hasegawa, Masashi; Ohtani, Nobuyo; Ohta, Mitsuaki

2014-02-27

The facial expressions and body postures of dogs can give helpful information about their moods and emotional states. People can more effectively obedience train their dogs if we can identify the mannerisms associated with learning in dogs. The aim of this study was to clarify the dog's body language during operant conditioning to predict achievement in the test that followed by measuring the duration of behaviors. Forty-six untrained dogs (17 males and 26 females) of various breeds were used. Each session consisted of 5 minutes of training with a treat reward followed by 3 minutes of rest and finally an operant conditioning test that consisted of 20 "hand motion" cues. The operant tests were conducted a total of nine times over three consecutive days, and the success numbers were counted. The duration of the dog's behavior, focusing on the dog's eyes, mouth, ears, tail and tail-wagging, was recorded during the operant conditioning sessions before the test. Particular behaviors, including wide-eyes, closed mouth, erect ears, and forward and high tail carriage, without wagging or with short and quick wagging, related to high achievement results. It is concluded that dogs' body language during operant conditioning was related to their success rate.

Measuring psychological trauma after spinal cord injury: Development and psychometric characteristics of the SCI-QOL Psychological Trauma item bank and short form

PubMed Central

Kisala, Pamela A.; Victorson, David; Pace, Natalie; Heinemann, Allen W.; Choi, Seung W.; Tulsky, David S.

2015-01-01

Objective To describe the development and psychometric properties of the SCI-QOL Psychological Trauma item bank and short form. Design Using a mixed-methods design, we developed and tested a Psychological Trauma item bank with patient and provider focus groups, cognitive interviews, and item response theory based analytic approaches, including tests of model fit, differential item functioning (DIF) and precision. Setting We tested a 31-item pool at several medical institutions across the United States, including the University of Michigan, Kessler Foundation, Rehabilitation Institute of Chicago, the University of Washington, Craig Hospital and the James J. Peters/Bronx Veterans Administration hospital. Participants A total of 716 individuals with SCI completed the trauma items Results The 31 items fit a unidimensional model (CFI=0.952; RMSEA=0.061) and demonstrated good precision (theta range between 0.6 and 2.5). Nine items demonstrated negligible DIF with little impact on score estimates. The final calibrated item bank contains 19 items Conclusion The SCI-QOL Psychological Trauma item bank is a psychometrically robust measurement tool from which a short form and a computer adaptive test (CAT) version are available. PMID:26010967

Software Quality Assurance and Verification for the MPACT Library Generation Process

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Yuxuan; Williams, Mark L.; Wiarda, Dorothea

This report fulfills the requirements for the Consortium for the Advanced Simulation of Light-Water Reactors (CASL) milestone L2:RTM.P14.02, “SQA and Verification for MPACT Library Generation,” by documenting the current status of the software quality, verification, and acceptance testing of nuclear data libraries for MPACT. It provides a brief overview of the library generation process, from general-purpose evaluated nuclear data files (ENDF/B) to a problem-dependent cross section library for modeling of light-water reactors (LWRs). The software quality assurance (SQA) programs associated with each of the software used to generate the nuclear data libraries are discussed; specific tests within the SCALE/AMPX andmore » VERA/XSTools repositories are described. The methods and associated tests to verify the quality of the library during the generation process are described in detail. The library generation process has been automated to a degree to (1) ensure that it can be run without user intervention and (2) to ensure that the library can be reproduced. Finally, the acceptance testing process that will be performed by representatives from the Radiation Transport Methods (RTM) Focus Area prior to the production library’s release is described in detail.« less

Molecular diagnostics for human leptospirosis.

PubMed

Waggoner, Jesse J; Pinsky, Benjamin A

2016-10-01

The definitive diagnosis of leptospirosis, which results from infection with spirochetes of the genus Leptospira, currently relies on the use of culture, serological testing (microscopic agglutination testing), and molecular detection. The purpose of this review is to describe new molecular diagnostics for Leptospira and discuss advancements in the use of available methods. Efforts have been focused on improving the clinical sensitivity of Leptospira detection using molecular methods. In this review, we describe a reoptimized pathogenic species-specific real-time PCR (targeting lipL32) that has demonstrated improved sensitivity, findings by two groups that real-time reverse-transcription PCR assays targeting the 16S rrs gene can improve detection, and two new loop-mediated amplification techniques. Quantitation of leptospiremia, detection in different specimen types, and the complementary roles played by molecular detection and microscopic agglutination testing will be discussed. Finally, a protocol for Leptospira strain subtyping using variable number tandem repeat targets and high-resolution melting will be described. Molecular diagnostics have an established role for the diagnosis of leptospirosis and provide an actionable diagnosis in the acute setting. The use of real-time reverse-transcription PCR for testing serum/plasma and cerebrospinal fluid, when available, may improve the detection of Leptospira without decreasing clinical specificity.

A review of consensus test methods for established medical imaging modalities and their implications for optical coherence tomography

NASA Astrophysics Data System (ADS)

Pfefer, Joshua; Agrawal, Anant

2012-03-01

In recent years there has been increasing interest in development of consensus, tissue-phantom-based approaches for assessment of biophotonic imaging systems, with the primary goal of facilitating clinical translation of novel optical technologies. Well-characterized test methods based on tissue phantoms can provide useful tools for performance assessment, thus enabling standardization and device inter-comparison during preclinical development as well as quality assurance and re-calibration in the clinical setting. In this review, we study the role of phantom-based test methods as described in consensus documents such as international standards for established imaging modalities including X-ray CT, MRI and ultrasound. Specifically, we focus on three image quality characteristics - spatial resolution, spatial measurement accuracy and image uniformity - and summarize the terminology, metrics, phantom design/construction approaches and measurement/analysis procedures used to assess these characteristics. Phantom approaches described are those in routine clinical use and tend to have simplified morphology and biologically-relevant physical parameters. Finally, we discuss the potential for applying knowledge gained from existing consensus documents in the development of standardized, phantom-based test methods for optical coherence tomography.

Building Knowledge Structures by Testing Helps Children With Mathematical Learning Difficulty.

PubMed

Zhang, Yiyun; Zhou, Xinlin

2016-01-01

Mathematical learning difficulty (MLD) is prevalent in the development of mathematical abilities. Previous interventions for children with MLD have focused on number sense or basic mathematical skills. This study investigated whether mathematical performance of fifth grade children with MLD could be improved by developing knowledge structures by testing using a web-based curriculum learning system. A total of 142 children with MLD were recruited; half of the children were in the experimental group (using the system), and the other half were in the control group (not using the system). The children were encouraged to use the web-based learning system at home for at least a 15-min session, at least once a week, for one and a half months. The mean accumulated time of testing on the system for children in the experimental group was 56.2 min. Children in the experimental group had significantly higher scores on their final mathematical examination compared to the control group. The results suggest that web-based curriculum learning through testing that promotes the building of knowledge structures for a mathematical course was helpful for children with MLD. © Hammill Institute on Disabilities 2014.

Process development for automated solar cell and module production. Task 4: Automated array assembly

NASA Technical Reports Server (NTRS)

Hagerty, J. J.

1981-01-01

Progress in the development of automated solar cell and module production is reported. The unimate robot is programmed for the final 35 cell pattern to be used in the fabrication of the deliverable modules. The mechanical construction of the automated lamination station and final assembly station phases are completed and the first operational testing is underway. The final controlling program is written and optimized. The glass reinforced concrete (GRC) panels to be used for testing and deliverables are in production. Test routines are grouped together and defined to produce the final control program.

Integrated Data Collection Analysis (IDCA) Program — IDCA Quarterly Program Review, September 14 and 15, 2010

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sandstrom, Mary M.; Brown, Geoffrey W.; Warner, Kirstin F.

The IDCA conducted a program review at Los Alamos National Laboratory, September 14 and 15, 2010. The review was divided into three parts: 1) an update on the current status of the program, 2) an information exchange and discussion on technical details for current issues and future planning, and 3) a tour of the SSST testing facilities at LANL. The meeting started with an update from DHS by Laura Parker and a restating of some of the objectives of the Proficiency Test of which the IDCA is currently engaged. This update was followed by a discussion of some high levelmore » programmatic issues particularly about ways of communicating the overall goals of the IDCA to non-technical representatives. The final topic focused on the difficulty of releasing information, including the DHS approval process, ITAR, and open publication. Next JGR presented a technical summary of accomplishments, schedule, milestones, and future directions. These key points made were: 1) about 1/3 of the materials have been tested, 2) some participants are behind others causing a lag in report writing, 3) method reports have been assigned to various participants to speed up the process of reporting, 4) the SSST Compendium needs reformatting and restructuring, and 5) the Compendium needs a web site to house with access control. After the technical update, some of the Proficiency Test results were shown comparing data from the various laboratories. These results included comparisons of the RDX standard, KC/sugar mixtures (-100 mesh and as received), KC/dodecane, KP/Al, and KP/C. Impact, friction, ESD, and DSC results were the focus. All the participants were involved in these discussions. This report includes summary notes, presentations, and explanatory information.« less

A novel approach for preparation and in situ tensile testing of silica glass membranes in the TEM

NASA Astrophysics Data System (ADS)

Mačković, Mirza; Przybilla, Thomas; Dieker, Christel; Herre, Patrick; Romeis, Stefan; Stara, Hana; Schrenker, Nadine; Peukert, Wolfgang; Spiecker, Erdmann

2017-04-01

The mechanical behavior of glasses in the micro- and/or nanometer regime increasingly gains importance in nowadays modern technology. However, suitable small scale preparation and mechanical testing approaches for a reliable assessment of the mechanical properties of glasses still remain a big challenge. In the present work, a novel approach for site-specific preparation and quantitative in situ tensile testing of thin silica glass membranes in the transmission electron microscope is presented. Thereby, advanced focused ion beam techniques are used for the preparation of nanoscale dog bone shaped silica glass specimens suitable for in situ tensile testing. Small amounts of gallium are detected on the surface of the membranes resulting from redeposition effects during the focused ion beam preparation procedure. Possible structural changes of silica glass upon irradiation with electrons and gallium ions are investigated by controlled irradiation experiments, followed by a structural analysis using Raman spectroscopy. While moderate electron beam irradiation does not alter the structure of silica glass, ion beam irradiation results in minor densification of the silica glass membranes. In situ tensile testing of membranes under electron beam irradiation results in distinctive elongations without fracture confirming the phenomenon of superplasticity. In contrast, in situ tensile testing in the absence of the electron beam reveals an elastic/plastic deformation behavior, and finally leads to fracture of the membranes. The Young’s moduli of the glass membranes pulled at beam off conditions in the TEM are comparable with values known for bulk fused silica, while the tensile strength is in the range of values reported for silica glass fibers with comparable dimensions. The impact of electron beam irradiation on the mechanical properties of silica glass membranes is further discussed. The results of the present work open new avenues for dedicated preparation and nanomechanical characterization of silica glasses, and further contribute to a fundamental understanding of the mechanical behavior of such glasses when being scaled down to the nanometer regime.

Development and testing of study tools and methods to examine ethnic bias and clinical decision-making among medical students in New Zealand: The Bias and Decision-Making in Medicine (BDMM) study.

PubMed

Harris, Ricci; Cormack, Donna; Curtis, Elana; Jones, Rhys; Stanley, James; Lacey, Cameron

2016-07-11

Health provider racial/ethnic bias and its relationship to clinical decision-making is an emerging area of research focus in understanding and addressing ethnic health inequities. Examining potential racial/ethnic bias among medical students may provide important information to inform medical education and training. This paper describes the development, pretesting and piloting of study content, tools and processes for an online study of racial/ethnic bias (comparing Māori and New Zealand European) and clinical decision-making among final year medical students in New Zealand (NZ). The study was developed, pretested and piloted using a staged process (eight stages within five phases). Phase 1 included three stages: 1) scoping and conceptual framework development; 2) literature review and identification of potential measures and items; and, 3) development and adaptation of study content. Three main components were identified to assess different aspects of racial/ethnic bias: (1) implicit racial/ethnic bias using NZ-specific Implicit Association Tests (IATs); (2) explicit racial/ethnic bias using direct questions; and, (3) clinical decision-making, using chronic disease vignettes. Phase 2 (stage 4) comprised expert review and refinement. Formal pretesting (Phase 3) included construct testing using sorting and rating tasks (stage 5) and cognitive interviewing (stage 6). Phase 4 (stage 7) involved content revision and building of the web-based study, followed by pilot testing in Phase 5 (stage 8). Materials identified for potential inclusion performed well in construct testing among six participants. This assisted in the prioritisation and selection of measures that worked best in the New Zealand context and aligned with constructs of interest. Findings from the cognitive interviewing (nine participants) on the clarity, meaning, and acceptability of measures led to changes in the final wording of items and ordering of questions. Piloting (18 participants) confirmed the overall functionality of the web-based questionnaire, with a few minor revisions made to the final study. Robust processes are required in the development of study content to assess racial/ethnic bias in order to optimise the validity of specific measures, ensure acceptability and minimise potential problems. This paper has utility for other researchers in this area by informing potential development approaches and identifying possible measurement tools.

Validation of source approval of HMA surface mix aggregate : final report.

DOT National Transportation Integrated Search

2016-04-01

The main focus of this research project was to develop methodologies for the validation of source approval of hot : mix asphalt surface mix aggregate. In order to further enhance the validation process, a secondary focus was also to : create a spectr...

Mississippi Department of Transportation Research Division peer exchange II final report : September 24-26, 2002.

DOT National Transportation Integrated Search

2009-01-01

A peer exchange can discuss general research management, or the agency can focus on certain parts of the research process. MDOT chose to focus on four themes: 1) Current Research Organization, 2) Identifying improvements That Streamline the Research ...

Effective Multifocus Image Fusion Based on HVS and BP Neural Network

PubMed Central

Yang, Yong

2014-01-01

The aim of multifocus image fusion is to fuse the images taken from the same scene with different focuses to obtain a resultant image with all objects in focus. In this paper, a novel multifocus image fusion method based on human visual system (HVS) and back propagation (BP) neural network is presented. Three features which reflect the clarity of a pixel are firstly extracted and used to train a BP neural network to determine which pixel is clearer. The clearer pixels are then used to construct the initial fused image. Thirdly, the focused regions are detected by measuring the similarity between the source images and the initial fused image followed by morphological opening and closing operations. Finally, the final fused image is obtained by a fusion rule for those focused regions. Experimental results show that the proposed method can provide better performance and outperform several existing popular fusion methods in terms of both objective and subjective evaluations. PMID:24683327

What Do Final Year Medical Students Understand by the Concept of Recovery? A Descriptive Qualitative Study.

PubMed

Newton-Howes, Giles; Beverley, Georgia; Ellis, Pete M; Gordon, Sarah; Levack, William

2018-06-01

Traditional teaching in psychiatry does little to address recovery concepts. The aim of this study was to evaluate the incorporation of a recovery-focused teaching program for medical students in psychiatry. Recovery, as understood by medical students who had participated in a recovery-focused teaching program, was assessed by thematic analysis of recovery-focused assessment reflections. Six major themes emerged from the recovery reflections from final year medical students are as follows: (1) recovery as a person-centered approach, (2) the need for social integration, (3) non-diagnostic framing of mental illness, (4) tensions between the medical model and personal recovery, (5) a patient's willingness to engage with mental health services, and (6) the development of a positive sense of self. A recovery teaching program was associated with students expressing knowledge of recovery principles and positive attitudes towards people with experience of mental illness. Psychiatric placements for medical students may benefit from a recovery focus.

Autochthonous lactic acid bacteria with probiotic aptitudes as starter cultures for fish-based products.

PubMed

Speranza, Barbara; Racioppo, Angela; Beneduce, Luciano; Bevilacqua, Antonio; Sinigaglia, Milena; Corbo, Maria Rosaria

2017-08-01

This study focused on the selection of lactic starters with probiotic properties for the production of fermented fish-products by the use of a multivariate approach (Cluster Analysis and Principal Component Analysis). Seventy-five isolates were recovered from fish intestinal microbiota and characterized by evaluating phenotypical, technological and probiotic traits; the most promising isolates were molecularly identified and then used into fish fermented sausage production. Namely, data from technological characterization were modelled through Growth Index and used as input to run a preliminary selection. Thus, 15 promising strains were selected and subjected to probiotic characterization; considering the results from probiotic tests, 3 promising strains were finally chosen (11, 68 and 69), identified as members of the genus Lactobacillus and used for the validation at laboratory level through the assessment of their performances for the production of fermented fish sausages. The results were promising as the use of the selected strains reduced the fermentation time (2 days) ensuring a good microbiological quality of the final product. Copyright © 2017 Elsevier Ltd. All rights reserved.

Final Technical Report for DE-SC0012297

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dell'Antonio, Ian

This is the final report on the work performed in award DE-SC0012297, Cosmic Frontier work in support of the LSST Dark Energy Science Collaboration's work to develop algorithms, simulations, and statistical tests to ensure optimal extraction of the dark energy properties from galaxy clusters observed with LSST. This work focused on effects that could produce a systematic error on the measurement of cluster masses (that will be used to probe the effects of dark energy on the growth of structure). These effects stem from the deviations from pure ellipticity of the gravitational lensing signal and from the blending of lightmore » of neighboring galaxies. Both these effects are expected to be more significant for LSST than for the stage III experiments such as the Dark Energy Survey. We calculate the magnitude of the mass error (or bias) for the first time and demonstrate that it can be treated as a multiplicative correction and calibrated out, allowing mass measurements of clusters from gravitational lensing to meet the requirements of LSST's dark energy investigation.« less

Michigan Early Adolescent Survey: Final Report.

ERIC Educational Resources Information Center

Keith, Joanne; And Others

This document contains the final report from the Michigan Early Adolescent Survey, a study undertaken to: (1) develop a profile of Michigan early adolescents that focused on out-of-school time and included biological, psychological, and sociological information; (2) develop a profile of families which included early adolescents; (3) assess the…

An Iterative Approach for Identifying the Causes of Reduced Benthic Macroinvertebrate Diversity in the Willimantic River, Connecticut (Final)

EPA Science Inventory

EPA announced the availability of the final report, An Iterative Approach for Identifying the Causes of Reduced Benthic Macroinvertebrate Diversity in the Willimantic River, Connecticut. This study demonstrates that a screening assessment can help to focus sampling for ...

Special Education Evaluation Project for University Affiliated Facilities. Final Report.

ERIC Educational Resources Information Center

Burrello, Leonard C.; And Others

The final report of the Special Education Evaluation Project for 16 University Affiliated Facilities (UAF) centers provides a chronological review of the project which focused on the training of persons to work with mentally retarded or other handicapped individuals. Outlined are project objectives including the development of descriptors useful…

Children in Hospitals: A Model Program. Final Report.

ERIC Educational Resources Information Center

Brill, Nancy; Cohen, Sarale

This final report describes the rationale, goals and activities of a federally funded project that was designed to develop a model intervention program for hospitalized chronically ill children between birth and five years. The focus of the program was to promote optimal emotional development: attachment, separation, individualization, and…

Initial development and psychometric testing of an instrument to measure the quality of children's end-of-life care.

PubMed

Widger, Kimberley; Tourangeau, Ann E; Steele, Rose; Streiner, David L

2015-01-01

The field of pediatric palliative care is hindered by the lack of a well-defined, reliable, and valid method for measuring the quality of end-of-life care. The study purpose was to develop and test an instrument to measure mothers' perspectives on the quality of care received before, at the time of, and following a child's death. In Phase 1, key components of quality end-of-life care for children were synthesized through a comprehensive review of research literature. These key components were validated in Phase 2 and then extended through focus groups with bereaved parents. In Phase 3, items were developed to assess structures, processes, and outcomes of quality end-of-life care then tested for content and face validity with health professionals. Cognitive testing was conducted through interviews with bereaved parents. In Phase 4, bereaved mothers were recruited through 10 children's hospitals/hospices in Canada to complete the instrument, and psychometric testing was conducted. Following review of 67 manuscripts and 3 focus groups with 10 parents, 141 items were initially developed. The overall content validity index for these items was 0.84 as rated by 7 health professionals. Based on feedback from health professionals and cognitive testing with 6 parents, a 144-item instrument was finalized for further testing. In Phase 4, 128 mothers completed the instrument, 31 of whom completed it twice. Test-retest reliability, internal consistency, and construct validity were demonstrated for six subscales: Connect With Families, Involve Parents, Share Information With Parents, Share Information Among Health Professionals, Support Parents, and Provide Care at Death. Additional items with content validity were grouped in four domains: Support the Child, Support Siblings, Provide Bereavement Follow-up, and Structures of Care. Forty-eight items were deleted through psychometric testing, leaving a 95-item instrument. There is good initial evidence for the reliability and validity of this new quality of end-of-life care instrument as a mechanism for evaluative feedback to health professionals, health systems, and policy makers to improve children's end-of-life care.

Development and evaluation of a thermochemistry concept inventory for college-level general chemistry

NASA Astrophysics Data System (ADS)

Wren, David A.

The research presented in this dissertation culminated in a 10-item Thermochemistry Concept Inventory (TCI). The development of the TCI can be divided into two main phases: qualitative studies and quantitative studies. Both phases focused on the primary stakeholders of the TCI, college-level general chemistry instructors and students. Each phase was designed to collect evidence for the validity of the interpretations and uses of TCI testing data. A central use of TCI testing data is to identify student conceptual misunderstandings, which are represented as incorrect options of multiple-choice TCI items. Therefore, quantitative and qualitative studies focused heavily on collecting evidence at the item-level, where important interpretations may be made by TCI users. Qualitative studies included student interviews (N = 28) and online expert surveys (N = 30). Think-aloud student interviews (N = 12) were used to identify conceptual misunderstandings used by students. Novice response process validity interviews (N = 16) helped provide information on how students interpreted and answered TCI items and were the basis of item revisions. Practicing general chemistry instructors (N = 18), or experts, defined boundaries of thermochemistry content included on the TCI. Once TCI items were in the later stages of development, an online version of the TCI was used in expert response process validity survey (N = 12), to provide expert feedback on item content, format and consensus of the correct answer for each item. Quantitative studies included three phases: beta testing of TCI items (N = 280), pilot testing of the a 12-item TCI (N = 485), and a large data collection using a 10-item TCI ( N = 1331). In addition to traditional classical test theory analysis, Rasch model analysis was also used for evaluation of testing data at the test and item level. The TCI was administered in both formative assessment (beta and pilot testing) and summative assessment (large data collection), with items performing well in both. One item, item K, did not have acceptable psychometric properties when the TCI was used as a quiz (summative assessment), but was retained in the final version of the TCI based on the acceptable psychometric properties displayed in pilot testing (formative assessment).

Computer-aided dispatch--traffic management center field operational test final detailed test plan : WSDOT deployment

DOT National Transportation Integrated Search

2003-10-01

The purpose of this document is to expand upon the evaluation components presented in "Computer-aided dispatch--traffic management center field operational test final evaluation plan : WSDOT deployment". This document defines the objective, approach,...