Sample records for final section briefly

  1. Preventing Sexual Abuse of Children in the Twenty-First Century: Preparing for Challenges and Opportunities

    ERIC Educational Resources Information Center

    Wurtele, Sandy K.

    2009-01-01

    Child sexual abuse is a widespread social problem that negatively affects victims, families, communities, and society. This article briefly describes the scope and consequences of child sexual abuse and briefly critiques child-focused personal safety educational programs designed to prevent sexual victimization. The final section offers…

  2. Numerical conformal mapping: Methods, applications, and theory. Final report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    DeLillo, T.K.

    1995-11-01

    Section 1 of this report, briefly summarizes research performed under this grant during the first two years 1992 to 1994 and makes some overall remarks. Section 2, summarizes research performed during the final year from September, 1994 through May 31, 1995, more fully. The main achievement of the last period has been the application of numerical conformed mapping to the solution of the biharmonic equation. Section 3, summarizes travel, meetings, and other expenses supported by this grant during the final year.

  3. STS-73 (USML-2) Final Report

    NASA Technical Reports Server (NTRS)

    Rice, James E.

    1996-01-01

    The report is organized into sections representing the phases of work performed in analyzing the STS-73 (USML-2) results. Section 1 briefly outlines the Orbital Acceleration Research Experiment (OARE), system features, coordinates, and measurement parameters. Section 2 describes the results from STS-73. The mission description, data calibration, and representative data obtained on STS-73 are presented. Also, the anomalous performance of OARE on STS-73 is discussed. Finally, Section 3 presents a discussion of accuracy achieved and achievable with OARE.

  4. OARE STS-75 (USMP-3) Final Report

    NASA Technical Reports Server (NTRS)

    Rice, James E.

    1996-01-01

    The report is organized into sections representing the phases of work performed in analyzing the STS-75 (USMP-3) results. Section 1 briefly outlines the Orbital Acceleration Research Experiment (OARE) system features, coordinates, and measurement parameters. Section 2 describes the results from STS-75. The mission description, data calibration, and representative data obtained on STS-75 are presented. Also, the anomalous performance of OARE on STS-75 is discussed. Finally, Section 3 presents a discussion of accuracy achieved and achievable with OARE.

  5. Components of Individual Differences in Human Intelligence. Final Report.

    ERIC Educational Resources Information Center

    Sternberg, Robert J.

    This final report reviews the main theoretical and empirical developments concerning components of individual differences in human intelligence. The report is divided into three main sections. The first briefly reviews alternative approaches to understanding the nature of intelligence. The second provides the proposed componential metatheory, a…

  6. OARE STS-78 (LMS-1) Final Report

    NASA Technical Reports Server (NTRS)

    Rice, James E.

    1996-01-01

    The report is organized into sections representing the phases of work performed in analyzing the STS-78 (LMS-1) results. Section 1 briefly outlines the Orbital Acceleration Research Experiment (OARE) system features, coordinates, and measurement parameters. Section 2 describes the results from STS-78. The mission description, data calibration, and representative data obtained on STS-78 are presented. Also, the anomalous performance of OARE on STS-78 is discussed. Finally, Section 3 presents a discussion of accuracy achieved and achievable with OARE. Appendix A discusses the data processing methodology in detail.

  7. Implications of Declining Enrolment for the Schools of Ontario. A Statement of Effects and Solutions. Final Report. [Incidences de la Baisse des Effectifs Scolaires sur les Ecoles de l'Ontario. Problemes et Solutions. Rapport Final].

    ERIC Educational Resources Information Center

    Jackson, R. W. B.

    In this final report concerning declining enrollments in Ontario, the problems are defined almost entirely in economic and financial terms, and the solutions expressed in those terms. The first section of the report briefly reviews the essential background, the economic and financial constraints, and finally the demographic facts. The arguments…

  8. [BO-CEC National Advisory Committee Meetings and Conference: January 21, 1974; January 13, 1975; July 15, 1975:] Appendix B.

    ERIC Educational Resources Information Center

    1975

    Appendix B to the final report of the Business and Office Career Education Curriculum (BO-CEC) project contains three sections. Sections 1 and 2 briefly present the agenda, the participants, and the reports of the BO-CEC National Advisory Committee Meetings of January 1974 and January 1975. Section 3 concerns the July 1975 dissemination conference…

  9. OARE STS-87 (USMP-4)

    NASA Technical Reports Server (NTRS)

    Rice, James E.

    1998-01-01

    The report is organized into sections representing the phases of work performed in analyzing the STS-87 (USMP-4) results. Section 1 briefly outlines the OARE system features, coordinates, and measurement parameters. Section 2 describes the results from STS-87. The mission description, data calibration, and representative data obtained on STS-87 are presented. Finally, Section 3 presents a discussion of accuracy achieved and achievable with OARE. Appendix A discusses the calibration and data processing methodology in detail.

  10. User's Manual for LINER: FORTRAN Code for the Numerical Simulation of Plane Wave Propagation in a Lined Two-Dimensional Channel

    NASA Technical Reports Server (NTRS)

    Reichert, R, S.; Biringen, S.; Howard, J. E.

    1999-01-01

    LINER is a system of Fortran 77 codes which performs a 2D analysis of acoustic wave propagation and noise suppression in a rectangular channel with a continuous liner at the top wall. This new implementation is designed to streamline the usage of the several codes making up LINER, resulting in a useful design tool. Major input parameters are placed in two main data files, input.inc and nurn.prm. Output data appear in the form of ASCII files as well as a choice of GNUPLOT graphs. Section 2 briefly describes the physical model. Section 3 discusses the numerical methods; Section 4 gives a detailed account of program usage, including input formats and graphical options. A sample run is also provided. Finally, Section 5 briefly describes the individual program files.

  11. Induced environment contamination monitor: Preliminary results from the Spacelab 1 flight

    NASA Technical Reports Server (NTRS)

    Miller, E. R. (Editor)

    1984-01-01

    The STS-9/Induced Environment Contamination Monitor (IECM) mission is briefly described. Preliminary results and analyses are given for each of the 10 instruments comprising the IECM. The final section presents a summary of the major results.

  12. Manpower Policies and the Disadvantaged

    DTIC Science & Technology

    disadvantaged . The history of manpower policy in the United States is briefly reviewed as are some of the more important pieces of legislation. This leads...to a discussion of programs in being, followed by a section on barriers to employment which the disadvantaged must surmount. Finally,the paper

  13. Application of the BEf-scaling approach to electron impact excitation of diople-allowed electronic states in molecules

    NASA Astrophysics Data System (ADS)

    Brunger, M. J.; Thorn, P. A.; Campbell, L.; Kato, H.; Kawahara, H.; Hoshino, M.; Tanaka, H.; Kim, Y.-K.

    2008-05-01

    We consider the efficacy of the BEf-scaling approach, in calculating reliable integral cross sections for electron impact excitation of dipole-allowed electronic states in molecules. We will demonstrate, using specific examples in H2, CO and H2O, that this relatively simple procedure can generate quite accurate integral cross sections which compare well with available experimental data. Finally, we will briefly consider the ramifications of this to atmospheric and other types of modelling studies.

  14. A Short Account of RRKM Theory of Unimolecular Reactions and of Marcus Theory of Electron Transfer in a Historical Perspective

    ERIC Educational Resources Information Center

    Di Giacomo, Francesco

    2015-01-01

    The RRKM Theory of Unimolecular Reactions and Marcus Theory of Electron Transfer are here briefly discussed in a historical perspective. In the final section, after a general discussion on the educational usefulness of teaching chemistry in a historical framework, hints are given on how some characteristics of Marcus' work could be introduced in…

  15. OARE STS-94 (MSL-1R)

    NASA Technical Reports Server (NTRS)

    Rice, James E.

    1998-01-01

    The report is organized into sections representing the phases of work performed in analyzing the STS-94 (MSL-IR) results. STS-94 (MSL1R) is a reflight of the STS-83 (MSL-1) mission which was terminated early because of a fuel cell problem. Section I briefly outlines the OARE system features, coordinates, and measurement parameters. Section 2 describes the results from STS-94. The mission description, data calibration, and representative data obtained on STS-94 are presented. Also, the anomalous performance of OARE on STS-94 is discussed. Finally, Section 3 presents a discussion of accuracy achieved and achievable with OARE. Appendix A discuss the calibration and data processing methodology in detail.

  16. A Real Alternative: The Final Report and Recommendations of the Community National Field Task Force on the Improvement and Reform of American Education.

    ERIC Educational Resources Information Center

    Office of Education (DHEW), Washington, DC.

    This report is one of six to be released by as many task forces on educational improvement and reform. The main body of this report consists of five sections: (a) an introduction, which briefly describes the work of the task force; (b) a description of the alternative of community participation in education; (c) recommendations; (d) access to…

  17. Neuroimaging Techniques: a Conceptual Overview of Physical Principles, Contribution and History

    NASA Astrophysics Data System (ADS)

    Minati, Ludovico

    2006-06-01

    This paper is meant to provide a brief overview of the techniques currently used to image the brain and to study non-invasively its anatomy and function. After a historical summary in the first section, general aspects are outlined in the second section. The subsequent six sections survey, in order, computed tomography (CT), morphological magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), diffusion-tensor magnetic resonance imaging (DWI/DTI), positron emission tomography (PET), and electro- and magneto-encephalography (EEG/MEG) based imaging. Underlying physical principles, modelling and data processing approaches, as well as clinical and research relevance are briefly outlined for each technique. Given the breadth of the scope, there has been no attempt to be comprehensive. The ninth and final section outlines some aspects of active research in neuroimaging.

  18. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Minati, Ludovico

    This paper is meant to provide a brief overview of the techniques currently used to image the brain and to study non-invasively its anatomy and function. After a historical summary in the first section, general aspects are outlined in the second section. The subsequent six sections survey, in order, computed tomography (CT), morphological magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), diffusion-tensor magnetic resonance imaging (DWI/DTI), positron emission tomography (PET), and electro- and magneto-encephalography (EEG/MEG) based imaging. Underlying physical principles, modelling and data processing approaches, as well as clinical and research relevance are briefly outlined for each technique. Givenmore » the breadth of the scope, there has been no attempt to be comprehensive. The ninth and final section outlines some aspects of active research in neuroimaging.« less

  19. International ultraviolet explorer observatory operations

    NASA Technical Reports Server (NTRS)

    1986-01-01

    This volume contains the Final Report for the International Ultraviolet Explorer (IUE) Observatory Operations contract, NAS5-28787. The report summarizes the activities of the IUE Observatory over the 13-month period from November 1985 through November 1986 and is arranged in sections according to the functions specified in the Statement of Work (SOW) of the contract. In order to preserve numerical correspondence between the technical SOW elements specified by the contract and the sections of this report, project management activities (SOW element 0.0.) are reported here in Section 7, following the reports of technical SOW elements 1.0 through 6.0. Routine activities have been summarized briefly whenever possible; statistical compilations, reports, and more lengthy supplementary material are contained in the Appendices.

  20. Information Systems: An Introduction for Adult Educators.

    ERIC Educational Resources Information Center

    Caldwell, Phyllis A.

    In this paper, the author's primary focus is on a marketing information system and its potential importance for adult educators. The content is in seven sections. The first two sections briefly introduce information systems in general and their relevance for adult educators. The third section briefly describes general management information…

  1. Differential cross-sections measurements for hadrontherapy: 50 MeV/A 12C reactions on H, C, O, Al and natTi targets

    NASA Astrophysics Data System (ADS)

    Divay, C.; Colin, J.; Cussol, D.; Finck, Ch.; Karakaya, Y.; Labalme, M.; Rousseau, M.; Salvador, S.; Vanstalle, M.

    2017-09-01

    In order to keep the benefits of a carbon treatment, the dose and biological effects induced by secondary fragments must be taken into account when simulating the treatment plan. These Monte-Carlo simulations codes are done using nuclear models that are constrained by experimental data. It is hence necessary to have precise measurements of the production rates of these fragments all along the beam path and for its whole energy range. In this context, a series of experiments aiming to measure the double differential fragmentation cross-sections of carbon on thin targets of medical interest has been started by our collaboration. In March 2015, an experiment was performed with a 50 MeV/nucleon 12C beam at GANIL. During this experiment, energy and angular differential cross-section distributions on H, C, O, Al and natTi have been measured. In the following, the experimental set-up and analysis process are briefly described and some experimental results are presented. Comparisons between several exit channel models from Phits and Geant4 show great discrepancies with the experimental data. Finally, the homemade Sliipie model is briefly presented and preliminary results are compared to the data with a promising outcome.

  2. Research traditions in provider-consumer interaction: implications for cancer care.

    PubMed

    O'Hair, Dan

    2003-05-01

    The increasing importance of communication in cancer research should play a role in shaping the research agendas of those interested in investigations involving providers and consumers of cancer care. The goal of this article is to identify existing programs of research specific to provider-patient relationships and infer implications for how these research traditions can lead to important research avenues in the cancer context. Research programs reviewed in this article include (a) relational control messages and (b) patient preferences for communication style. Each section briefly reviews some noteworthy trends emanating from that research tradition and concludes with implications for future research. In the final section, two promising directions of research are proposed for consumer-provider communication.

  3. MRI of articular cartilage at microscopic resolution

    PubMed Central

    Xia, Y.

    2013-01-01

    This review briefly summarises some of the definitive studies of articular cartilage by microscopic MRI (µMRI) that were conducted with the highest spatial resolutions. The article has four major sections. The first section introduces the cartilage tissue, MRI and µMRI, and the concept of image contrast in MRI. The second section describes the characteristic profiles of three relaxation times (T1, T2 and T1ρ) and self-diffusion in healthy articular cartilage. The third section discusses several factors that can influence the visualisation of articular cartilage and the detection of cartilage lesion by MRI and µMRI. These factors include image resolution, image analysis strategies, visualisation of the total tissue, topographical variations of the tissue properties, surface fibril ambiguity, deformation of the articular cartilage, and cartilage lesion. The final section justifies the values of multidisciplinary imaging that correlates MRI with other technical modalities, such as optical imaging. Rather than an exhaustive review to capture all activities in the literature, the studies cited in this review are merely illustrative. PMID:23610697

  4. Aerial gamma ray and magnetic survey, Mississippi and Florida airborne survey: Baton Rouge quadrangle, Louisiana and Mississippi. Final report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1980-10-01

    The Baton Rouge quadrangle covers 8250 square miles in the Mississippi River delta area. The area overlies thick sections of the Gulf of Mexico Basin. Surficial exposures are dominated by Recent and Pleistocene sediment. A search of available literature revealed no known uranium deposits. A total of 87 uranium anomalies were detected and are discussed briefly in this report. None were considered significant and all appear to relate to cultural features. Magnetic data appears to be in agreement with existing structural interpretations of the area.

  5. Automatic Traffic Advisory and Resolution Service (ATARS) Algorithms Including Resolution-Advisory-Register Logic. Volume 1. Sections 1 through 11,

    DTIC Science & Technology

    1981-06-01

    Donald Roberts contributed to the final design review and editing of this document as well as having overall project and technical management...and Reporting function 7. A Data Extraction function 1-5 2. SYSTEM OVERVIEW The basic concept of ATARS is very briefly reviewed here as background to...8-P30 PRM threatadvisorydeerination; If! ((SVECT1.CUNC 12 %P&LSZ jfl SV2c?t.ITSEQ 11 UNflQ) (SVUCT2.CUNC 12 SPILS2 LU SYICT2.&TS2Q j1, UIZQ)) TRS 2W

  6. A review of in situ propellant production techniques for solar system exploration

    NASA Technical Reports Server (NTRS)

    Hoffman, S. J.

    1983-01-01

    Representative studies done in the area of extraterrestrial chemical production as it applies to solar system exploration are presented. A description of the In Situ Propellant Production (ISPP) system is presented. Various propellant combinations and direct applications along with the previously mentioned benefits and liens are discussed. A series of mission scenarios is presented which is studied in the greatest detail. A general description of the method(s) of analysis used to study each mission is provided. Each section will be closed by an assessment of the performance advantage, if any, that can be provided by ISPP. A final section briefly summarizes those missions which, as a result of the studies completed thus far, should see a sizable benefit from the use of ISPP.

  7. Survey of selected topics relevant to bioprocess engineering. Technical note (Final)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hubbard, J.B.; Clark, E.J.; Levelt Sengers, J.M.H.

    1990-05-01

    The following is a collection of reports on topics considered important and generic in biotechnology and bioprocess engineering: (1) Isoelectric points of proteins; (2) Solubility and mass transfer of oxygen in bioreactors; (3) Solubility and mass transfer of carbon dioxide in bioreactors. The reports arose from a survey of the past and current biotechnology literature with special effort given to a critique of data measurement quality. The format is as follows. The technological importance of a topic is briefly discussed, followed by a critical review of relevant physical properties, data presentation, and measurement techniques. A conclusions and recommendations section summarizesmore » the findings and contains specific recommendations for future research projects. The last section consists of an annotated bibliography and references pertaining to the survey.« less

  8. Molecular photoionization processes of astrophysical and aeronomical interest

    NASA Technical Reports Server (NTRS)

    Langhoff, P. W.

    1985-01-01

    An account is given of aspects of photoionization processes in molecules, with particular reference to recent theoretical and experimental studies of partial cross sections for production of specific final electronic states and of parent and fragment ions. Such cross sections help provide a basis for specifying the state of excitation of the ionized medium, are useful for estimating the kinetic energy distributions of photoejected electrons and fragment ions, provide parent-and fragment-ion yields, and clarify the possible origins of neutral fragments in highly excited rovibronic states. A descriptive account is given of photoionization phenomena, including tabulation of valence- and inner-shell potentials for some molecules of astrophysical and aeronomical interest. Cross sectional expressions are given. Various approximations currently employed in computational studies are described briefly, threshold laws and high-energy limits are indicated, and distinction is drawn between resonant and direct photoionization phenomena. Recent experimental and theoretical studies of partial photoionization cross sections in selected compounds of astrophysical and aeronomical relevance are described and discussed.

  9. Tracking and data relay satellite system configuration and tradeoff study. Volume 4: TDRS system operation and control and telecommunications service system, part 1

    NASA Technical Reports Server (NTRS)

    1972-01-01

    Major study areas treated in this volume are: 1) operations and control and 2) the telecommunication service system. The TDRS orbit selection, orbital deployment, ground station visibility, sequence of events from launch to final orbit position, and TDRS control center functions required for stationkeeping, repositioning, attitude control, and antenna pointing are briefly treated as part of the operations and control section. The last topic of this section concerns the operations required for efficiently providing the TDRSS user telecommunication services. The discussion treats functions of the GSFC control and data processing facility, ground station, and TDRS control center. The second major portion of this volume deals with the Telecommunication Service System (TSS) which consists of the ground station, TDRS communication equipment and the user transceiver. A summary of the requirements and objectives for the telecommunication services and a brief summary of the TSS capabilities is followed by communication system analysis, signal design, and equipment design. Finally, descriptions of the three TSS elements are presented.

  10. A critical analysis towards research perspectives: Reply to comments on "Modeling human behavior in economics and social science".

    PubMed

    Dolfin, M; Leonida, L; Outada, N

    2017-12-01

    We take advantage of the challenging comments to the modeling approach we proposed in [35] to look ahead at a number of applications of the methods to the alternative questions these comments raise. In turn, our effort results in a number of interesting and valuable research perspectives. The presentation goes along three main lines. In the first line, we summarize briefly the aims and results in [35]. In the second section we give a technical the issues raised and, finally, the focus moves to the above mentioned research perspectives. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. Christian Soteriology and Extraterrestrial Intelligence

    NASA Astrophysics Data System (ADS)

    Weidemann, C.

    The paper presents an argument for the incompatibility of classical Christian soteriology (doctrine of salvation) with belief in numerous extraterrestrial intelligent life forms (ETI). Four popular answers to the problem are discussed and rejected: a) unlike humanity, extraterrestrial intelligent species are not in need of salvation; b) Jesus of Nazareth has reconciled the entire cosmos to God; c) God or the second person of the Trinity has incarnated (or will incarnate) himself multiple times; d) alien sinners have been or are going to be saved by means different from a divine incarnation. The final section deals with remaining options for rational Christian believers and speculates briefly about consequences for interstellar space flight.

  12. Organizational climate and culture.

    PubMed

    Schneider, Benjamin; Ehrhart, Mark G; Macey, William H

    2013-01-01

    Organizational climate and organizational culture theory and research are reviewed. The article is first framed with definitions of the constructs, and preliminary thoughts on their interrelationships are noted. Organizational climate is briefly defined as the meanings people attach to interrelated bundles of experiences they have at work. Organizational culture is briefly defined as the basic assumptions about the world and the values that guide life in organizations. A brief history of climate research is presented, followed by the major accomplishments in research on the topic with regard to levels issues, the foci of climate research, and studies of climate strength. A brief overview of the more recent study of organizational culture is then introduced, followed by samples of important thinking and research on the roles of leadership and national culture in understanding organizational culture and performance and culture as a moderator variable in research in organizational behavior. The final section of the article proposes an integration of climate and culture thinking and research and concludes with practical implications for the management of effective contemporary organizations. Throughout, recommendations are made for additional thinking and research.

  13. Current status of water environment and their microbial biosensor techniques - Part II: Recent trends in microbial biosensor development.

    PubMed

    Nakamura, Hideaki

    2018-05-08

    In Part I of the present review series, I presented the current state of the water environment by focusing on Japanese cases and discussed the need to further develop microbial biosensor technologies for the actual water environment. I comprehensively present trends after approximately 2010 in microbial biosensor development for the water environment. In the first section, after briefly summarizing historical studies, recent studies on microbial biosensor principles are introduced. In the second section, recent application studies for the water environment are also introduced. Finally, I conclude the present review series by describing the need to further develop microbial biosensor technologies. Graphical abstract Current water pollution indirectly occurs by anthropogenic eutrophication (Part I). Recent trends in microbial biosensor development for water environment are described in part II of the present review series.

  14. Research on Darrieus-type hydraulic turbine for extra-low head hydropower utilization

    NASA Astrophysics Data System (ADS)

    Furukawa, A.; Watanabe, S.; Okuma, K.

    2012-11-01

    A Darrieus-type turbine has been investigated for extra-low head hydropower utilization. In the present paper, authors'research on Darrieus-type hydraulic turbine is briefly reviewed. The working principle of Darrieus turbine is explained with advantage of its simple structure, at first. Then the fluid-dynamic difference between rotating and linear motions of a blade in a uniform flow is clarified with guiding principle of high performance design of Darrieus turbine. Cavitation problem is also described. Next, effects of duct-casing, consisting of an intake, runner section and draft tube, are discussed and a simplified structure of Darrieus turbine is shown by installing the inlet nozzle. Finally, in the practical use, an adjustment of inlet nozzle section by lowering the inlet nozzle height is proposed when flow rate is varied temporally and seasonally.

  15. Nuclear and Radiochemistry: the First 100 Years

    NASA Astrophysics Data System (ADS)

    Friedlander, G.; Herrmann, G.

    This chapter gives a brief overview of the development of nuclear and radiochemistry from Mme. Curie's chemical isolation of radium toward the end of the twentieth century. The first four sections deal with fairly distinct time periods: (1) the pioneering years when the only radioactive materials available were the naturally occurring ones; (2) the decade of rapid growth and expansion of both the fundamental science and its applications following the discoveries of the neutron and artificial radioactivity; (3) the World War II period characterized by the intense exploration of nuclear fission and its ramifications; (4) what can be called the “golden era” - the 3 to 4 decades following World War II when nuclear science was generously supported and therefore flourished. In the final section, research trends pursued near the end of the century are briefly touched upon.

  16. Modeling Value Chain Analysis of Distance Education using UML

    NASA Astrophysics Data System (ADS)

    Acharya, Anal; Mukherjee, Soumen

    2010-10-01

    Distance education continues to grow as a methodology for the delivery of course content in higher education in India as well as abroad. To manage this growing demand and to provide certain flexibility, there must be certain strategic planning about the use of ICT tools. Value chain analysis is a framework for breaking down the sequence of business functions into a set of activities through which utility could be added to service. Thus it can help to determine the competitive advantage that is enjoyed by an institute. To implement these business functions certain visual representation is required. UML allows for this representation by using a set of structural and behavioral diagrams. In this paper, the first section defines a framework for value chain analysis and highlights its advantages. The second section gives a brief overview of related work in this field. The third section gives a brief discussion on distance education. The fourth section very briefly introduces UML. The fifth section models value chain of distance education using UML. Finally we discuss the limitations and the problems posed in this domain.

  17. Practical Formal Verification of Diagnosability of Large Models via Symbolic Model Checking

    NASA Technical Reports Server (NTRS)

    Cavada, Roberto; Pecheur, Charles

    2003-01-01

    This document reports on the activities carried out during a four-week visit of Roberto Cavada at the NASA Ames Research Center. The main goal was to test the practical applicability of the framework proposed, where a diagnosability problem is reduced to a Symbolic Model Checking problem. Section 2 contains a brief explanation of major techniques currently used in Symbolic Model Checking, and how these techniques can be tuned in order to obtain good performances when using Model Checking tools. Diagnosability is performed on large and structured models of real plants. Section 3 describes how these plants are modeled, and how models can be simplified to improve the performance of Symbolic Model Checkers. Section 4 reports scalability results. Three test cases are briefly presented, and several parameters and techniques have been applied on those test cases in order to produce comparison tables. Furthermore, comparison between several Model Checkers is reported. Section 5 summarizes the application of diagnosability verification to a real application. Several properties have been tested, and results have been highlighted. Finally, section 6 draws some conclusions, and outlines future lines of research.

  18. A Project to Develop Career Awareness Materials for Special Needs Students. Final Report. Research Series No. 19.

    ERIC Educational Resources Information Center

    Rustan, Jack; And Others

    The report briefly describes a project to develop career orientation materials for special needs students--disadvantaged and educable mentally handicapped (EMH)--at the junior and senior high school levels in North Dakota. The activities involved in selecting the career areas are briefly discussed. By polling various students in different parts of…

  19. Physiotherapy students' experiences of bullying on clinical internships: an exploratory study.

    PubMed

    Stubbs, Brendon; Soundy, Andy

    2013-06-01

    To consider the prevalence and type of bullying behaviours experienced whilst on clinical placement in a cohort of final-year BSc undergraduate students. Cross-sectional survey. University in the West Midlands, UK. Fifty-two final-year undergraduate students. Prevalence of incivility and bullying behaviours. Twenty-five percent of students reported at least one incident of bullying behaviour. The perpetrator of the bullying behaviour was most often the clinical educator (8/13, 62%). Despite the negative effects caused, the majority of students (11/13, 84%) did not report this experience to the university. Bullying behaviour may take many forms and can have a negative effect on the well-being of students. It should be addressed by all stakeholders including universities, National Health Service trusts and researchers. Possible strategies to move forwards and better protect the future of the physiotherapy profession are briefly considered. Copyright © 2013 Chartered Society of Physiotherapy. Published by Elsevier Ltd. All rights reserved.

  20. A framework for the modeling of gut blood flow regulation and postprandial hyperaemia

    PubMed Central

    Jeays, Adam David; Lawford, Patricia Veronica; Gillott, Richard; Spencer, Paul A; Bardhan, Karna Dev; Hose, David Rodney

    2007-01-01

    After a meal the activity of the gut increases markedly as digestion takes place. Associated with this increase in activity is an increase in blood flow, which has been shown to be dependent on factors such as caloric content and constitution of the meal. Much qualitative work has been carried out regarding mechanisms for the presence of food in a section of gut producing increased blood flow to that section, but there are still many aspects of this process that are not fully understood. In this paper we briefly review current knowledge on several relevant areas relating to gut blood flow, focusing on quantitative data where available and highlighting areas where further research is needed. We then present new data on the effect of feeding on flow in the superior mesenteric artery. Finally, we describe a framework for combining this data to produce a single model describing the mechanisms involved in postprandial hyperaemia. For a section of the model, where appropriate data are available, preliminary results are presented. PMID:17457971

  1. Emerging Technologies for Cancer Research: towards Personalized Medicine with Microfluidic Platforms and 3D Tumor Models.

    PubMed

    Turetta, Matteo; Ben, Fabio Del; Brisotto, Giulia; Biscontin, Eva; Bulfoni, Michela; Cesselli, Daniela; Colombatti, Alfonso; Scoles, Giacinto; Gigli, Giuseppe; Del Mercato, Loretta L

    2018-06-05

    In the present review, we describe three hot topics in cancer research such as circulating tumor cells, exosomes, and 3D environment models. The first section is dedicated to microfluidic platforms for detecting circulating tumor cells, including both affinity-based methods that take advantage of antibodies and aptamers, and "label-free" approaches, exploiting cancer cells physical features and, more recently, abnormal cancer metabolism. In the second section, we briefly describe biology of exosomes and their role in cancer, as well as conventional techniques for their isolation and innovative microfluidic platforms. In the third section, the importance of tumor microenvironment is highlighted, along with techniques for modeling it in vitro. Finally, we discuss limitations of two-dimensional monolayer methods and describe advantages and disadvantages of different three-dimensional tumor systems for cell-cell interaction analysis and their potential applications in cancer management. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  2. Consequences of Age-Related Cognitive Declines

    PubMed Central

    Salthouse, Timothy

    2013-01-01

    Adult age differences in a variety of cognitive abilities are well documented, and many of those abilities have been found to be related to success in the workplace and in everyday life. However, increased age is seldom associated with lower levels of real-world functioning, and the reasons for this lab-life discrepancy are not well understood. This article briefly reviews research concerned with relations of age to cognition, relations of cognition to successful functioning outside the laboratory, and relations of age to measures of work performance and achievement. The final section discusses several possible explanations for why there are often little or no consequences of age-related cognitive declines in everyday functioning. PMID:21740223

  3. Making medicine scientific: empiricism, rationality, and quackery in mid-Victorian Britain.

    PubMed

    Weatherall, M W

    1996-08-01

    This paper discusses the strategies used to construct scientific medicine in mid-Victorian Britain. An opening section considers why it was thought desirable to create a properly scientific medicine, and outlines the empirical and rational bases of the medical establishment's projects for this. The bulk of the paper concerns an alternative approach to making medicine scientific--that put forward by certain advocates of homoeopathy--and how this approach was excluded from those arenas where scientific medicine was being created, and thereby made unscientific. This process is illustrated by the clash between homoeopathy and establishment medicine that occurred in mid-Victorian Cambridge. The final section briefly considers the complementary process of educating the public in what was properly scientific medicine, and what was not, and suggests that the processes of building boundaries to exclude competing practitioners, while keeping patients inside, created the space in which modern scientific medicine has flourished so successfully.

  4. Causative Agents of Aspergillosis Including Cryptic Aspergillus Species and A. fumigatus.

    PubMed

    Toyotome, Takahito

    2016-01-01

    Aspergillosis is an important deep mycosis. The causative agents are Aspergillus fumigatus, Aspergillus flavus, Aspergillus niger, and Aspergillus terreus, of which A. fumigatus is the most prevalent. Cryptic Aspergillus spp., which morphologically resemble representative species of each Aspergillus section, also cause aspergillosis. Most of the cryptic species reveal different susceptibility patterns and/or different secondary metabolite profiles, also called exometabolome in this manuscript, from those representative species. On the other hand, azole-resistant A. fumigatus strains in clinical specimens and in the environment have been reported. Therefore, it is imperative to precisely identify the species, including cryptic Aspergillus spp., and evaluate the susceptibility of isolates.In this manuscript, some of the causative cryptic Aspergillus spp. are briefly reviewed. In addition, the exometabolome of Aspergillus section Fumigati is described. Finally, azole resistance of A. fumigatus is also discussed, in reference to several studies from Japan.

  5. Applications of Parallel Computation in Micro-Mechanics and Finite Element Method

    NASA Technical Reports Server (NTRS)

    Tan, Hui-Qian

    1996-01-01

    This project discusses the application of parallel computations related with respect to material analyses. Briefly speaking, we analyze some kind of material by elements computations. We call an element a cell here. A cell is divided into a number of subelements called subcells and all subcells in a cell have the identical structure. The detailed structure will be given later in this paper. It is obvious that the problem is "well-structured". SIMD machine would be a better choice. In this paper we try to look into the potentials of SIMD machine in dealing with finite element computation by developing appropriate algorithms on MasPar, a SIMD parallel machine. In section 2, the architecture of MasPar will be discussed. A brief review of the parallel programming language MPL also is given in that section. In section 3, some general parallel algorithms which might be useful to the project will be proposed. And, combining with the algorithms, some features of MPL will be discussed in more detail. In section 4, the computational structure of cell/subcell model will be given. The idea of designing the parallel algorithm for the model will be demonstrated. Finally in section 5, a summary will be given.

  6. Chemical protection against ionizing radiation. Final report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Livesey, J.C.; Reed, D.J.; Adamson, L.F.

    1984-08-01

    The scientific literature on radiation-protective drugs is reviewed. Emphasis is placed on the mechanisms involved in determining the sensitivity of biological material to ionizing radiation and mechanisms of chemical radioprotection. In Section I, the types of radiation are described and the effects of ionizing radiation on biological systems are reviewed. The effects of ionizing radiation are briefly contrasted with the effects of non-ionizing radiation. Section II reviews the contributions of various natural factors which influence the inherent radiosensitivity of biological systems. Inlcuded in the list of these factors are water, oxygen, thiols, vitamins and antioxidants. Brief attention is given tomore » the model describing competition between oxygen and natural radioprotective substances (principally, thiols) in determining the net cellular radiosensitivity. Several theories of the mechanism(s) of action of radioprotective drugs are described in Section III. These mechanisms include the production of hypoxia, detoxication of radiochemical reactive species, stabilization of the radiobiological target and the enhancement of damage repair processes. Section IV describes the current strategies for the treatment of radiation injury. Likely areas in which fruitful research might be performed are described in Section V. 495 references.« less

  7. Epigenetics: ambiguities and implications.

    PubMed

    Stotz, Karola; Griffiths, Paul

    2016-12-01

    Everyone has heard of 'epigenetics', but the term means different things to different researchers. Four important contemporary meanings are outlined in this paper. Epigenetics in its various senses has implications for development, heredity, and evolution, and also for medicine. Concerning development, it cements the vision of a reactive genome strongly coupled to its environment. Concerning heredity, both narrowly epigenetic and broader 'exogenetic' systems of inheritance play important roles in the construction of phenotypes. A thoroughly epigenetic model of development and evolution was Waddington's aim when he introduced the term 'epigenetics' in the 1940s, but it has taken the modern development of molecular epigenetics to realize this aim. In the final sections of the paper we briefly outline some further implications of epigenetics for medicine and for the nature/nurture debate.

  8. Neutron-Induced Fission Measurements at the Dance and Lsds Facilities at Lanl

    NASA Astrophysics Data System (ADS)

    Jandel, M.; Bredeweg, T. A.; Bond, E. M.; Chadwick, M. B.; Couture, A.; O'Donnell, J. M.; Fowler, M. M.; Haight, R. C.; Hayes-Sterbenz, A. C.; Rundberg, R. S.; Rusev, G. Y.; Ullmann, J. L.; Vieira, D. J.; Wilhelmy, J. B.; Wu, C. Y.; Becker, J. A.; Alexander, C. W.; Belier, G.

    2014-09-01

    New results from neutron-induced fission measurements performed at the Detector for Advanced Neutron Capture Experiments (DANCE) and Lead Slowing Down Spectrometer (LSDS) are presented. New correlated data on promptfission γ-ray (PFG) distributions were measured using the DANCE array for resonant neutron-induced fission of 233U, 235U and 239Pu. The deduced properties of PFG emission are presented using a simple parametrization. An accurate knowledge of fission γ-ray spectra enables us to analyze the isomeric states of 236U created after neutron capture on 235U. We briefly discuss these new results. Finally, we review details and preliminary results of the challenging 237U(n,f) cross section measurement at the LSDS facility.

  9. Research status of wave energy conversion (WEC) device of raft structure

    NASA Astrophysics Data System (ADS)

    Dong, Jianguo; Gao, Jingwei; Tao, Liang; Zheng, Peng

    2017-10-01

    This paper has briefly described the concept of wave energy generation and six typical conversion devices. As for raft structure, detailed analysis is provided from its development process to typical devices. Taking the design process and working principle of Plamis as an example, the general principle of raft structure is briefly described. After that, a variety of raft structure models are introduced. Finally, the advantages and disadvantages, and development trend of raft structure are pointed out.

  10. TRENCADIS - secure architecture to share and manage DICOM objects in a ontological framework based on OGSA.

    PubMed

    Blanquer, Ignacio; Hernandez, Vicente; Segrelles, Damià; Torres, Erik

    2007-01-01

    Today most European healthcare centers use the digital format for their databases of images. TRENCADIS is a software architecture comprising a set of services as a solution for interconnecting, managing and sharing selected parts of medical DICOM data for the development of training and decision support tools. The organization of the distributed information in virtual repositories is based on semantic criteria. Different groups of researchers could organize themselves to propose a Virtual Organization (VO). These VOs will be interested in specific target areas, and will share information concerning each area. Although the private part of the information to be shared will be removed, special considerations will be taken into account to avoid the access by non-authorized users. This paper describes the security model implemented as part of TRENCADIS. The paper is organized as follows. First introduces the problem and presents our motivations. Section 1 defines the objectives. Section 2 presents an overview of the existing proposals per objective. Section 3 outlines the overall architecture. Section 4 describes how TRENCADIS is architected to realize the security goals discussed in the previous sections. The different security services and components of the infrastructure are briefly explained, as well as the exposed interfaces. Finally, Section 5 concludes and gives some remarks on our future work.

  11. Educational Information System for Ontario. Final Report, March 1977-April 1978.

    ERIC Educational Resources Information Center

    Auster, Ethel; Lawton, Stephen B.

    This final report describing the operation and research of the EISO project, which provides online bibliographic search services to educators of Ontario, briefly summarizes the first and second interim reports. In addition, it discusses users and the uses of EISO information by providing mini-case studies to illustrate quantitative data and…

  12. Digital-Computer Processing of Graphical Data. Final Report.

    ERIC Educational Resources Information Center

    Freeman, Herbert

    The final report of a two-year study concerned with the digital-computer processing of graphical data. Five separate investigations carried out under this study are described briefly, and a detailed bibliography, complete with abstracts, is included in which are listed the technical papers and reports published during the period of this program.…

  13. Focus on Statistical Physics Modeling in Economics and Finance

    NASA Astrophysics Data System (ADS)

    Mantegna, Rosario N.; Kertész, János

    2011-02-01

    This focus issue presents a collection of papers on recent results in statistical physics modeling in economics and finance, commonly known as econophysics. We touch briefly on the history of this relatively new multi-disciplinary field, summarize the motivations behind its emergence and try to characterize its specific features. We point out some research aspects that must be improved and briefly discuss the topics the research field is moving toward. Finally, we give a short account of the papers collected in this issue.

  14. Scientific and Technical Support for the Galileo Net Flux Radiometer Experiment

    NASA Technical Reports Server (NTRS)

    Sromovsky, Lawrence A.

    1997-01-01

    This report describes work in support of the Galileo Net Flux Radiometer (NFR), an instrument mounted on the Galileo probe, a spacecraft designed for entry into and direct measurements of Jupiter's atmosphere. Tasks originally proposed for the post launch period covered by NCC 2-854 are briefly as follows: attend and support PSG (Project Science Group) and other project science meetings; support in-flight checkouts; maintain and keep safe the spare instrument and GSE (Ground Support Equipment); organize and maintain documentation; finish NFR calibration measurements, documentation, and analysis; characterize and diagnose instrument anomalies; develop descent data analysis tools; and science data analysis and publication. Because we had the capability to satisfy a project support need we also subsequently proposed and were funded to make ground-based observations of Jupiter during the period surrounding the Galileo arrival at Jupiter, using the Swedish Solar Telescope at La Palma, Canary Islands. The following section provides background information on the NFR instrument. Section 3 contains the final report of work done.

  15. The Use of Natural Supports To Increase Integration in Supported Employment Settings for Youth in Transition. Final Report.

    ERIC Educational Resources Information Center

    Storey, Keith

    This final report briefly describes activities of a project which developed and evaluated specific natural support intervention procedures to increase the social integration of employees with severe disabilities using single-subject, clique analysis, and social validation methodologies. The project resulted in the publication of 6 journal articles…

  16. The Elder Abuse Prevention Project, Phase Two, Three and Four. Final Report.

    ERIC Educational Resources Information Center

    Regina Univ. (Saskatchewan). Univ. Extension. Seniors Education Centre.

    This document presents the final report from an educational and community development program designed to raise awareness about the abuse and neglect of the elderly. The Elder Abuse Prevention Project is briefly described in terms of project goals, objectives, the model used, the target groups served, and the evaluation processes employed. It is…

  17. Making Breakthroughs in the Turbulent Decade: China's Space Technology During the Cultural Revolution.

    PubMed

    Li, Chengzhi; Zhang, Dehui; Hu, Danian

    2017-09-01

    This article discusses why Chinese space programs were able to develop to the extent they did during the turbulent decade of the Cultural Revolution (1966-1976). It first introduces briefly what China had accomplished in rocket and missile technology before the Cultural Revolution, including the establishment of a system for research and manufacturing, breakthroughs in rocket technology, and programs for future development. It then analyzes the harmful impacts of the Cultural Revolution on Chinese space programs by examining activities of contemporary mass factions in the Seventh Ministry of Machinery Industry. In the third section, this article presents the important developments of Chinese space programs during the Cultural Revolution and explores briefly the significance of these developments for the future and overall progress in space technology. Finally, it discusses the reasons for the series of developments of Chinese space technology during the Cultural Revolution. This article concludes that, although the Cultural Revolution generated certain harmful impacts on the development of Chinese space technology, the Chinese essentially accomplished their scheduled objectives in their space program, both because of the great support of top Chinese leaders, including the officially disgraced Lin Biao and the Gang of Four, and due to the implementation of many effective special measures. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. Effect of bending on the room-temperature tensile strengths of structural ceramics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jenkins, M.G.

    1992-01-01

    Results for nearly fifty, room-temperature tensile tests conducted on two advanced, monolithic silicon nitride ceramics are evaluated for the effects of bending and application of various Weibull statistical analyses. Two specimen gripping systems (straight collet and tapered collet) were evaluated for both success in producing gage section failures and tendency to minimize bending at failure. Specimen fabrication and grinding technique consderations are briefly reviewed and related to their effects on successful tensile tests. Ultimate tensile strengths are related to the bending measured at specimen failure and the effects of the gripping system on bending are discussed. Finally, comparisons are mademore » between the use of censored and uncensored data sample sets for determining the maximum likelihood estimates of the Weibull parameters from the tensile strength distributions.« less

  19. Effect of bending on the room-temperature tensile strengths of structural ceramics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jenkins, M.G.

    1992-07-01

    Results for nearly fifty, room-temperature tensile tests conducted on two advanced, monolithic silicon nitride ceramics are evaluated for the effects of bending and application of various Weibull statistical analyses. Two specimen gripping systems (straight collet and tapered collet) were evaluated for both success in producing gage section failures and tendency to minimize bending at failure. Specimen fabrication and grinding technique consderations are briefly reviewed and related to their effects on successful tensile tests. Ultimate tensile strengths are related to the bending measured at specimen failure and the effects of the gripping system on bending are discussed. Finally, comparisons are mademore » between the use of censored and uncensored data sample sets for determining the maximum likelihood estimates of the Weibull parameters from the tensile strength distributions.« less

  20. Space-Based Space Surveillance Logistics Case Study: A Qualitative Product Support Element Analysis

    DTIC Science & Technology

    2017-12-01

    Facilities and Infrastructure. Product Support Management and Design Interface are also covered, but only in a general manner. Conclusions from the study...core analysis, with the overarching two elements ( Design Interface and Product Support Management) mentioned briefly. G. THESIS STATEMENT This...were implemented. The two overarching elements of Product Support Management and Design Interface will be discussed briefly in the findings section

  1. Final Report. Research in Theoretical High Energy Physics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Greensite, Jeffrey P.; Golterman, Maarten F.L.

    Grant-supported research in theoretical high-energy physics, conducted in the period 1992-2015 is briefly described, and a full listing of published articles result from those research activities is supplied.

  2. Early Childhood Education.

    ERIC Educational Resources Information Center

    Elkind, David

    In five sections, this paper explores dimensions of early childhood education: schooling generally construed as nonparental instruction in knowledge, values, and skills. Section 1 looks at some of the factors which have contributed to the rapid growth of early childhood education in modern times. Section 2 briefly highlights the contributions of…

  3. Information Networks and Education: An Analytic Bibliography.

    ERIC Educational Resources Information Center

    Pritchard, Roger

    This literature review presents a broad and overall perspective on the various kinds of information networks that will be useful to educators in developing nations. There are five sections to the essay. The first section cites and briefly describes the literature dealing with library, information, and computer networks. Sections two and three…

  4. ADA Guide for Small Businesses.

    ERIC Educational Resources Information Center

    Department of Justice, Washington, DC. Civil Rights Div.

    This guide presents an informal overview of some basic Americans with Disabilities Act (ADA) requirements for small businesses that provide goods or services to the public. References to key sections of the regulations or other information are included. The first section describes the ADA briefly. Section two lists the 12 categories of public…

  5. TA-55 Final Safety Analysis Report Comparison Document and DOE Safety Evaluation Report Requirements

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Alan Bond

    2001-04-01

    This document provides an overview of changes to the currently approved TA-55 Final Safety Analysis Report (FSAR) that are included in the upgraded FSAR. The DOE Safety Evaluation Report (SER) requirements that are incorporated into the upgraded FSAR are briefly discussed to provide the starting point in the FSAR with respect to the SER requirements.

  6. The intrinsic fluorescence of FAD and its application in analytical chemistry: a review

    NASA Astrophysics Data System (ADS)

    Galbán, Javier; Sanz-Vicente, Isabel; Navarro, Jesús; de Marcos, Susana

    2016-12-01

    This review (with 106 references) mainly deals with the analytical applications of flavin-adenine dinucleotide (FAD) fluorescence. In the first section, the spectroscopic properties of this compound are reviewed at the light of his different acid-base, oxidation and structural forms; the chemical and spectroscopic properties of flavin mononucleotide (FMN) and other flavins will be also briefly discussed. The second section discusses how the properties of FAD fluorescence changes in flavoenzymes (FvEs), again considering the different chemical and structural forms; the glucose oxidase (GOx) and the choline oxidase (ChOx) cases will be commented. Since almost certainly the most reported analytical application of FAD fluorescence is as an auto-indicator in enzymatic methods catalysed by FvE oxidoreductases, it is important to know how the concentrations of the different forms of FAD changes along the reaction and, consequently, the fluorescence and the analytical signals. An approach to do this will be presented in section 3. The fourth part of the paper compiles the analytical applications which have been reported until now based in these fluorescence properties. Finally, some suggestions about tentative future research are also given.

  7. The intrinsic fluorescence of FAD and its application in analytical chemistry: a review.

    PubMed

    Galbán, Javier; Sanz-Vicente, Isabel; Navarro, Jesús; de Marcos, Susana

    2016-12-19

    This review (with 106 references) mainly deals with the analytical applications of flavin-adenine dinucleotide (FAD) fluorescence. In the first section, the spectroscopic properties of this compound are reviewed at the light of his different acid-base, oxidation and structural forms; the chemical and spectroscopic properties of flavin mononucleotide (FMN) and other flavins will be also briefly discussed. The second section discusses how the properties of FAD fluorescence changes in flavoenzymes (FvEs), again considering the different chemical and structural forms; the glucose oxidase (GOx) and the choline oxidase (ChOx) cases will be commented. Since almost certainly the most reported analytical application of FAD fluorescence is as an auto-indicator in enzymatic methods catalysed by FvE oxidoreductases, it is important to know how the concentrations of the different forms of FAD changes along the reaction and, consequently, the fluorescence and the analytical signals. An approach to do this will be presented in section 3. The fourth part of the paper compiles the analytical applications which have been reported until now based in these fluorescence properties. Finally, some suggestions about tentative future research are also given.

  8. Astringency, bitterness and color changes in dry red wines before and during oak barrel aging: An updated phenolic perspective review.

    PubMed

    Li, Si-Yu; Duan, Chang-Qing

    2018-01-30

    To understand effects of using oak barrels on the astringency, bitterness and color of dry red wines, phenolic reactions in wines before and after barrel aging are reviewed in this paper, which has been divided into three sections. The first section includes an introduction to chemical reactivities of grape-derived phenolic compounds, a summary of the phenolic reactions that occur in dry red wines before barrel aging, and a discussion of the effects of these reactions on wine astringency, bitterness and color. The second section introduces barrel types that determine the oak barrel constituents in wines (primarily oak aldehydes and ellagitannins) and presents reactions between the oak constituents and grape-derived phenolic compounds that may modulate wine astringency, bitterness and color. The final section illustrates the chemical differences between basic oxidation and over-oxidation in wines, discusses oxygen consumption kinetics in wines during barrel aging by comparing different oxygen consumption kinetics observed previously by others, and speculates on the possible preliminary phenolic reactions that occur in dry red wines during oak barrel aging that soften tannins and stabilize pigments via basic oxidation. Additionally, sulfur dioxide (SO 2 ) addition during barrel aging and suitability of adopting oak barrels for aging wines are briefly discussed.

  9. Viscous Design of TCA Configuration

    NASA Technical Reports Server (NTRS)

    Krist, Steven E.; Bauer, Steven X. S.; Campbell, Richard L.

    1999-01-01

    The goal in this effort is to redesign the baseline TCA configuration for improved performance at both supersonic and transonic cruise. Viscous analyses are conducted with OVERFLOW, a Navier-Stokes code for overset grids, using PEGSUS to compute the interpolations between overset grids. Viscous designs are conducted with OVERDISC, a script which couples OVERFLOW with the Constrained Direct Iterative Surface Curvature (CDISC) inverse design method. The successful execution of any computational fluid dynamics (CFD) based aerodynamic design method for complex configurations requires an efficient method for regenerating the computational grids to account for modifications to the configuration shape. The first section of this presentation deals with the automated regridding procedure used to generate overset grids for the fuselage/wing/diverter/nacelle configurations analysed in this effort. The second section outlines the procedures utilized to conduct OVERDISC inverse designs. The third section briefly covers the work conducted by Dick Campbell, in which a dual-point design at Mach 2.4 and 0.9 was attempted using OVERDISC; the initial configuration from which this design effort was started is an early version of the optimized shape for the TCA configuration developed by the Boeing Commercial Airplane Group (BCAG), which eventually evolved into the NCV design. The final section presents results from application of the Natural Flow Wing design philosophy to the TCA configuration.

  10. Multilingualism in South Africa with Particular Reference to the Role of African Languages in Education

    NASA Astrophysics Data System (ADS)

    Desai, Zubeida

    2001-07-01

    In this paper it is argued that language policy can play a central role in enabling citizens of a country to participate in the political, educational, social and economic life of that country. Or it can deny them that right. In discussions on the role of African languages, there is a tendency to confine the discussion to language in education. I argue that unless we locate the discussion in a broader context, we are not going to make much progress in extending the use of African languages beyond the home domain. The paper therefore consists of three sections. The first section looks broadly at the domains where language has an impact. The second section briefly outlines a process underway in South Africa to develop a framework for a national language policy, whilst the final section looks at the implications of this for education. Here I look at language in Education Policy in Practice. I give examples from a piece of primary research that I have conducted with Xhosa -speaking Grade 4 and Grade 7 learners who have been given pictures to describe first in Xhosa and then in English. The examples show the rich vocabulary children have when they express themselves in Xhosa and the poor vocabulary they have when they express themselves in English.

  11. Current Issues: Critical Issues Confronting the Nation and the World. 1990 Edition.

    ERIC Educational Resources Information Center

    Close Up Foundation, Arlington, VA.

    This annual publication seeks to inform interested readers about issues currently confronting the United States. The introductory section briefly discusses the 101st Congress, members of the Bush administration, and the Supreme Court. The federal budget process is also discussed in this section. The section on domestic policy issues contains the…

  12. Photoabsorption and photodissociation of molecules important in the interstellar medium

    NASA Technical Reports Server (NTRS)

    Lee, L. C.

    1985-01-01

    The photoabsorption and photodissociation cross sections of several interstellar molecules and radicals in the 105 to 210 nm region were measured. The research results accomplished are briefly described. Photoabsorption cross sections of OD and CN, and photoabsorption and photodissociation of HCl, and photoabsorption and photodissociation cross sections of CH3OH are discussed.

  13. 99mTc: Labeling Chemistry and Labeled Compounds

    NASA Astrophysics Data System (ADS)

    Alberto, R.; Abram, U.

    This chapter reviews the radiopharmaceutical chemistry of technetium related to the synthesis of perfusion agents and to the labeling of receptor-binding biomolecules. To understand the limitations of technetium chemistry imposed by future application of the complexes in nuclear medicine, an introductory section analyzes the compulsory requirements to be considered when facing the incentive of introducing a novel radiopharmaceutical into the market. Requirements from chemistry, routine application, and market are discussed. In a subsequent section, commercially available 99mTc-based radiopharmaceuticals are treated. It covers the complexes in use for imaging the most important target organs such as heart, brain, or kidney. The commercially available radiopharmaceuticals fulfill the requirements outlined earlier and are discussed with this background. In a following section, the properties and perspectives of the different generations of radiopharmaceuticals are described in a general way, covering characteristics for perfusion agents and for receptor-specific molecules. Technetium chemistry for the synthesis of perfusion agents and the different labeling approaches for target-specific biomolecules are summarized. The review comprises a general introduction to the common approaches currently in use, employing the N x S4-x , [3+1] and 2-hydrazino-nicotinicacid (HYNIC) method as well as more recent strategies such as the carbonyl and the TcN approach. Direct labeling without the need of a bifunctional chelator is briefly reviewed as well. More particularly, recent developments in the labeling of concrete targeting molecules, the second generation of radiopharmaceuticals, is then discussed and prominent examples with antibodies/peptides, neuroreceptor targeting small molecules, myocardial imaging agents, vitamins, thymidine, and complexes relevant to multidrug resistance are given. In addition, a new approach toward peptide drug development is described. The section has a focus on coordination and labeling chemistry, but biological results are briefly summarized as well. The last (and shortest) section finally intends to give a (subjective) outlook for the future role of 99mTc-based radiopharmaceuticals. Critical comments are spread over the whole article but are concentrated in this section. Despite the increasing competition of diagnostic radiopharmacy by other commonly applied methods in medicine such as magnetic resonance imaging (MRI) or ultrasound, the authors are convinced that 99mTc will play a key role also in future if novel approaches are added and the requirements from chemistry biology and the market considered in research to a stronger extent.

  14. Metals and Ceramics Division progress report for period ending December 31, 1993

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Craig, D.F.; Bradley, R.A.; Weir, J.R. Jr.

    1994-07-01

    This report provides an overview of activities and accomplishsments of the division from October 1992 through December 1993; the division is organized to provide technical support, mainly in the area of high-temperature materials, for technologies being developed by DOE. Activities span the range from basic research to industrial interactions (cooperative research and technology transfer). Sections 1-5 describe the different functional groups (engineering materials, high-temperature materials, materials science, ceramics, nuclear fuel materials). Sect. 6 provides an alternative view of the division in terms of the major programs, most of which cross group lines. Sect. 7 summarizes external interactions including cooperative Rmore » and D programs and technology transfer functions. Finally, Sect. 8 briefly describes the division`s involvement in educational activities. Several organizational changes were effected during this period.« less

  15. A Critical Review of Glucose Biosensors Based on Carbon Nanomaterials: Carbon Nanotubes and Graphene

    PubMed Central

    Zhu, Zhigang; Garcia-Gancedo, Luis; Flewitt, Andrew J.; Xie, Huaqing; Moussy, Francis; Milne, William I.

    2012-01-01

    There has been an explosion of research into the physical and chemical properties of carbon-based nanomaterials, since the discovery of carbon nanotubes (CNTs) by Iijima in 1991. Carbon nanomaterials offer unique advantages in several areas, like high surface-volume ratio, high electrical conductivity, chemical stability and strong mechanical strength, and are thus frequently being incorporated into sensing elements. Carbon nanomaterial-based sensors generally have higher sensitivities and a lower detection limit than conventional ones. In this review, a brief history of glucose biosensors is firstly presented. The carbon nanotube and grapheme-based biosensors, are introduced in Sections 3 and 4, respectively, which cover synthesis methods, up-to-date sensing approaches and nonenzymatic hybrid sensors. Finally, we briefly outline the current status and future direction for carbon nanomaterials to be used in the sensing area. PMID:22778628

  16. Protein Separation by Capillary Gel Electrophoresis: A Review

    PubMed Central

    Zhu, Zaifang; Lu, Joann J.; Liu, Shaorong

    2011-01-01

    Capillary gel electrophoresis (CGE) has been used for protein separation for more than two decades. Due to the technology advancement, current CGE methods are becoming more and more robust and reliable for protein analysis, and some of the methods have been routinely used for the analysis of protein-based pharmaceuticals and quality controls. In light of this progress, we survey 147 papers related to CGE separations of proteins and present an overview of this technology. We first introduce briefly the early development of CGE. We then review the methodology, in which we specifically describe the matrices, coatings, and detection strategies used in CGE. CGE using microfabricated channels and incorporation of CGE with two-dimensional protein separations are also discussed in this section. We finally present a few representative applications of CGE for separating proteins in real-world samples. PMID:22122927

  17. Insights in Public Health

    PubMed Central

    Okamoto, Scott K; Maddock, Jay; Hayes, Donald; Lowery, Tonya; Rajan, Ranjani

    2013-01-01

    This article briefly outlines a collaboration among communities on Hawai‘i Island and a university-based research team to develop, implement, and evaluate a school-based substance use prevention curriculum called Ho‘ouna Pono. In addition to providing a rationale for the project, the goal of this paper is fourfold. First, an overview of the Ho‘ouna Pono research results to date (2007–2013) is provided. Second, within this overview, the ways in which selected results informed program development are highlighted. Third, the curriculum is briefly described, and finally, the role of the students and community in the video production is described. PMID:23463854

  18. Brown spot needle disease--biology and control in Scotch pine plantations.

    Treesearch

    Darroll D. Skilling; Thomas H. Nicholls

    1975-01-01

    An application section briefly describes and illustrates the symptoms, hosts, life history of the brown spot needlecast fungus (Scirrhia acicola), and recommends chemical and cultural control methods. A documentation section details the research on the biology and control of the fungus.

  19. Knowledge Management in Instructional Design. ERIC Digest.

    ERIC Educational Resources Information Center

    Spector, J. Michael; Edmonds, Gerald S.

    This digest reviews what instructional designers do, describes knowledge management, and indicates how knowledge management is influencing instructional design. The first section defines instructional design (ID) and briefly describes the ID process. The second section covers knowledge management (KM), including definitions of KM and systems,…

  20. Towards flexible solid-state supercapacitors for smart and wearable electronics.

    PubMed

    Dubal, Deepak P; Chodankar, Nilesh R; Kim, Do-Heyoung; Gomez-Romero, Pedro

    2018-03-21

    Flexible solid-state supercapacitors (FSSCs) are frontrunners in energy storage device technology and have attracted extensive attention owing to recent significant breakthroughs in modern wearable electronics. In this study, we review the state-of-the-art advancements in FSSCs to provide new insights on mechanisms, emerging electrode materials, flexible gel electrolytes and novel cell designs. The review begins with a brief introduction on the fundamental understanding of charge storage mechanisms based on the structural properties of electrode materials. The next sections briefly summarise the latest progress in flexible electrodes (i.e., freestanding and substrate-supported, including textile, paper, metal foil/wire and polymer-based substrates) and flexible gel electrolytes (i.e., aqueous, organic, ionic liquids and redox-active gels). Subsequently, a comprehensive summary of FSSC cell designs introduces some emerging electrode materials, including MXenes, metal nitrides, metal-organic frameworks (MOFs), polyoxometalates (POMs) and black phosphorus. Some potential practical applications, such as the development of piezoelectric, photo-, shape-memory, self-healing, electrochromic and integrated sensor-supercapacitors are also discussed. The final section highlights current challenges and future perspectives on research in this thriving field.

  1. Techniques for Sea Ice Characteristics Extraction and Sea Ice Monitoring Using Multi-Sensor Satellite Data in the Bohai Sea-Dragon 3 Programme Final Report (2012-2016)

    NASA Astrophysics Data System (ADS)

    Zhang, Xi; Zhang, Jie; Meng, Junmin

    2016-08-01

    The objectives of Dragon-3 programme (ID: 10501) are to develop methods for classification sea ice types and retrieving ice thickness based on multi-sensor data. In this final results paper, we give a briefly introduction for our research work and mainly results. Key words: the Bohai Sea ice, Sea ice, optical and

  2. Modelling regulation of decomposition and related root/mycorrhizal processes in arctic tundra soils. Final report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Linkins, A.E.

    1992-09-01

    Since this was the final year of this project principal activities were directed towards either collecting data needed to complete existing incomplete data sets or writing manuscripts. Data sets on Imnaviat Creek watershed basin are functionally complete and data finialized on the cellulose mineralizaiton and dust impact on soil organic carbon and phsophorus decomposition. Seven manuscripts were prepared, and are briefly outlined.

  3. Children in Contemporary Society: Child Ecology.

    ERIC Educational Resources Information Center

    Frank, Mary, Ed.

    This collection of short articles focuses on various dimensions of childhood ecology. Section I introduces a conceptual framework for the study of childhood ecology and poses 4 methodological principles for human development specialists. Four ecological subsystems are identified and discussed briefly. Section II discusses the family microsystem in…

  4. Eliminating Borders through Debate Education.

    ERIC Educational Resources Information Center

    Peterson, Keith; Clower, Ramona

    As the world moves into the millennium, students will need certain skills to be successful in a global environment. This paper argues that competitive international exposure through debate can provide these skills. The paper consists of three sections. The first section briefly reviews current literature identifying the academic and intercultural…

  5. An Introductory Guide to Entrepreneurship for American Indians.

    ERIC Educational Resources Information Center

    Jones, Enid B.; And Others

    Prepared to assist American Indians in initiating entrepreneurial activities, this booklet offers practical guidance on starting and operating a business. Section I defines the term "entrepreneurship," and provides a self-evaluation checklist focusing on the qualities needed by entrepreneurs. Section II briefly discusses four forms of ownership…

  6. Haida Months of the Year.

    ERIC Educational Resources Information Center

    Cogo, Robert

    Students are introduced to Haida vocabulary in this booklet which briefly describes the seasons and traditional seasonal activities of Southeastern Alaska Natives. The first section lists the months in English and Haida; e.g., January is "Taan Kungaay," or "Bear Hunting Month." The second section contains seasonal names in…

  7. Rx Articulation. A Guidebook to Successful Curriculum Articulation.

    ERIC Educational Resources Information Center

    Epps, Irvine

    This procedural guide is designed for program operators and service providers who are cognizant of the potential advantages of articulation and are interested in beginning or expanding articulation efforts. The guide's first section explains the various forms of articulation and reviews briefly benefits and barriers. Other sections introduce the…

  8. Student Financial Aid. Informational Paper No. 39.

    ERIC Educational Resources Information Center

    Larsen, Merry

    This monograph provides an overview of Wisconsin state and federal financial aid programs for students. The first section discusses the methodology used to determine student financial need. The second section briefly reviews the various sources of financial aid including the federal government, the Higher Educational Aids Board (HEAB), the…

  9. Hawaiian Performance Cartography of Kaua'i

    ERIC Educational Resources Information Center

    Akana, Kalani

    2013-01-01

    This article provides a discussion that examines Hawaiian performance cartography as described by Oliveira--but only as it relates to the island of Kaua'i. Section I begins with a chant asking permission to "enter" into the cultural landscape described in "mele" (songs) and "hula" (dance). Section II looks briefly at…

  10. Whither Performance Contracting?

    ERIC Educational Resources Information Center

    Green, Norman S.

    This report describes briefly performance contracts; discusses their shortcomings, pitfalls, and advantages; and gives some insight into the future development of this new concept. Two shortcomings of performance contracting include (1) teaching to the test and (2) board abdication of its responsibility for making final decisions about educational…

  11. Waterborne traffic Paints : a study for the potential improvement in drying time and cost-effectiveness : final report

    DOT National Transportation Integrated Search

    2000-05-15

    This report analyzes possibilities for developing an alternative to the present technology of 100% acrylic waterborne (WB) paints used for road delineation. The current market situation is briefly reviewed, and alternatives considered. The requiremen...

  12. Helicity and singular structures in fluid dynamics

    PubMed Central

    Moffatt, H. Keith

    2014-01-01

    Helicity is, like energy, a quadratic invariant of the Euler equations of ideal fluid flow, although, unlike energy, it is not sign definite. In physical terms, it represents the degree of linkage of the vortex lines of a flow, conserved when conditions are such that these vortex lines are frozen in the fluid. Some basic properties of helicity are reviewed, with particular reference to (i) its crucial role in the dynamo excitation of magnetic fields in cosmic systems; (ii) its bearing on the existence of Euler flows of arbitrarily complex streamline topology; (iii) the constraining role of the analogous magnetic helicity in the determination of stable knotted minimum-energy magnetostatic structures; and (iv) its role in depleting nonlinearity in the Navier-Stokes equations, with implications for the coherent structures and energy cascade of turbulence. In a final section, some singular phenomena in low Reynolds number flows are briefly described. PMID:24520175

  13. Three-dimensional Imaging and Scanning: Current and Future Applications for Pathology

    PubMed Central

    Farahani, Navid; Braun, Alex; Jutt, Dylan; Huffman, Todd; Reder, Nick; Liu, Zheng; Yagi, Yukako; Pantanowitz, Liron

    2017-01-01

    Imaging is vital for the assessment of physiologic and phenotypic details. In the past, biomedical imaging was heavily reliant on analog, low-throughput methods, which would produce two-dimensional images. However, newer, digital, and high-throughput three-dimensional (3D) imaging methods, which rely on computer vision and computer graphics, are transforming the way biomedical professionals practice. 3D imaging has been useful in diagnostic, prognostic, and therapeutic decision-making for the medical and biomedical professions. Herein, we summarize current imaging methods that enable optimal 3D histopathologic reconstruction: Scanning, 3D scanning, and whole slide imaging. Briefly mentioned are emerging platforms, which combine robotics, sectioning, and imaging in their pursuit to digitize and automate the entire microscopy workflow. Finally, both current and emerging 3D imaging methods are discussed in relation to current and future applications within the context of pathology. PMID:28966836

  14. Use of the Wigner representation in scattering problems

    NASA Technical Reports Server (NTRS)

    Bemler, E. A.

    1975-01-01

    The basic equations of quantum scattering were translated into the Wigner representation, putting quantum mechanics in the form of a stochastic process in phase space, with real valued probability distributions and source functions. The interpretative picture associated with this representation is developed and stressed and results used in applications published elsewhere are derived. The form of the integral equation for scattering as well as its multiple scattering expansion in this representation are derived. Quantum corrections to classical propagators are briefly discussed. The basic approximation used in the Monte-Carlo method is derived in a fashion which allows for future refinement and which includes bound state production. Finally, as a simple illustration of some of the formalism, scattering is treated by a bound two body problem. Simple expressions for single and double scattering contributions to total and differential cross-sections as well as for all necessary shadow corrections are obtained.

  15. On the Da Vinci size effect in tensile strengths of nanowires: A molecular dynamics study

    NASA Astrophysics Data System (ADS)

    Zhao, Ziyu; Liu, Jinxing; Soh, Ai Kah

    2018-01-01

    In recent decades, size effects caused by grain size, strain gradient, typical defects etc., have been widely investigated. Nevertheless, the dependence of tensile strength on the specimen length, addressed by Da Vinci around 500 hundred years ago, has received rather limited attention, even though it is one unavoidable question to answer if people attempt to bring materials' amazing nano-scale strengths up to macro-level. Therefore, we make efforts to study tensile behaviors of copper nanowires with a common cross-section and various lengths by employing the molecular dynamics simulations. Surprisingly, a strong size effect of Da Vinci type indeed arises. We have shown the influences of lattice orientation, temperature and prescribed notch on such a Da Vinci size effect. Two different theoretical explanations are briefly proposed for a qualitative understanding. Finally, a simple scaling rule is summarized to cover the tendencies observed.

  16. Public and private sector interactions: an economic perspective.

    PubMed

    Maynard, A

    1986-01-01

    The debate about the public-private mix for health care has been dominated by rhetoric and the failure to evaluate the characteristics of the outcomes of public and private health care systems and to relate these to policy targets. After a brief analysis of the competing, liberal (conservative) and collectivist (socialist), objectives, the nature of the private health care sector in Britain is described and it is shown that growth has faltered due to cost containment problems. This outcome is the product of characteristics of the private health care system, paralleled precisely in the NHS: asymmetry information, monopoly power, moral hazard and third party pays. The final section discusses briefly some remedies for the inefficient and inequitable outcomes which are seen in all health care markets and it is argued that competition within public and private health care systems may enable each system type to achieve its own particular objectives more efficiently.

  17. "Ray-intrusive" laticifers in species of Croton section Cyclostigma (Euphorbiaceae)

    Treesearch

    Alex C. Wiedenhoeft; Ricarda Riina; Paul E. Berry

    2009-01-01

    A description of the occurrence and structure of “ray-intrusive” laticifers in the rays of species of Croton section Cyclostigma is provided. The systematic significance of laticifers within Croton section Cyclostigma is briefly discussed in relation to the section’s known production of red latex, commonly called “dragon’s blood”. A developmental hypothesis is offered...

  18. Nutrition and Fitness Manual: A Summary of Research and Resources.

    ERIC Educational Resources Information Center

    MacDonald, Donna, Comp.; And Others

    Intended for use by fitness instructors, coaches, nutritionists, and other program leaders, this five-section manual covers topics ranging from curriculum guides for elementary school children to dietary regimes used by professional athletes. The role of nutrients and the use of Canada's Food Guide are reviewed briefly in the first section.…

  19. Job Development and Placement: CETA Program Models.

    ERIC Educational Resources Information Center

    Johnson, Miriam; Sugarman, Marged

    One of a series on Comprehensive Employment and Training Act (CETA) program models, this monograph provides professionals employed in CETA programs with information on how job recruiting and searches take place to help them improve their job placement and development skills. The content is in four sections. The first section briefly covers the…

  20. The Just Community School: The Theory and the Cambridge Cluster School Experiment.

    ERIC Educational Resources Information Center

    Kohlberg, Lawrence; And Others

    The background, evaluation process, theories, and practical aspects of the Just Community High School in Cambridge, Masachusetts, are presented. The document is organized into four sections. Section 1 briefly discusses the components of a Just School: participatory democracy with teachers and students having equal rights, emphasis on conflict…

  1. Psychotherapeutic Medication in the Treatment of Refugees.

    ERIC Educational Resources Information Center

    Jaranson, James M.

    This paper is an overview of issues and findings in the use of medication to treat mentally ill refugees. The introductory background section briefly discusses the development of interest in ethnic differences in response to psychotropic drugs. The second section highlights the results of research literature on the use of the following kinds of…

  2. The College Does It Better. A Resource for Colleges of Further Education.

    ERIC Educational Resources Information Center

    Further Education Unit, London (England).

    This resource contains checklists, worksheets, and examples to encourage staff to share their views and to precipitate action. It assumes an open system of college management with a desire to be efficiently and effectively responsive to local needs. Section I describes briefly some challenges the further education system faces. Section II…

  3. A Review of Literature on Coping with Teenage Pregnancy in the Community.

    ERIC Educational Resources Information Center

    Stambler, Moses

    Literature concerning problems that result from teenage pregnancy is synthesized and reviewed. The first section briefly compares rates of pregnancy among adolescents in the United States against those of other countries. This comparison is discussed in greater detail in the second section, which focuses on pregnancy rates in Connecticut and the…

  4. Making Thinking Audible and Visible via Cooperative Learning

    ERIC Educational Resources Information Center

    Jacobs, George M.; Wang, Aili; Li, Xishuang; Xie, Yongye

    2008-01-01

    This chapter begins with a section that describes cooperative learning and explains eight cooperative learning principles. The second section looks briefly at why making thinking audible and visible enriches students' thinking. Making thinking audible means that teachers and students speak out what is going through their minds as they do a task,…

  5. Robust Vocabulary Instruction in a Readers' Workshop

    ERIC Educational Resources Information Center

    Feezell, Greg

    2012-01-01

    This article presents strategies for integrating explicit vocabulary instruction within a reading workshop. The author begins by describing a process for involving students in word selection. The author then provides a weeklong instructional sequence using student-selected words. Finally, the author briefly examines the role of vocabulary…

  6. 1999 Transit customer satisfaction index : final report : results of survey and conclusions

    DOT National Transportation Integrated Search

    2000-10-01

    The purpose of this report is to provide an overview of the results and analysis of the data collected in the 1999 Florida Transit Properties Customer Satisfaction Index project, as well as to briefly review the data sources and the weighting methodo...

  7. Role of CCTs in the evolving domestic electricity market

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Grahame, T.J.

    1997-12-31

    The paper summarizes the key points and issues in the role of clean coal technologies in the domestic marketplace. Then suggested solutions to bringing precommercial CCTs to the market are presented. Finally, the outlook for possible actions by government and the private sector are briefly discussed.

  8. Stars in Alignment

    ERIC Educational Resources Information Center

    Sailor, Wayne S.; McCart, Amy B.

    2014-01-01

    After decades of effort to create inclusive education, the authors assert that the time for full inclusion to manifest at scale may finally be at hand. This article first briefly considers the background and history of the inclusive education movement. The authors then reframe the discourse by defining inclusion through structures and…

  9. Better utilization of low-grade woods

    Treesearch

    Peter Koch

    1957-01-01

    The objective of this paper is threefold: to outline briefly some of the avenues of approach so far employed in utilizing low-grade wood, to comment on the economic aspects of the problem, and finally, to speculate about what developments the future might bring to the field of utilization.

  10. Space Launch System Base Heating Test: Sub-Scale Rocket Engine/Motor Design, Development and Performance Analysis

    NASA Technical Reports Server (NTRS)

    Mehta, Manish; Seaford, Mark; Kovarik, Brian; Dufrene, Aaron; Solly, Nathan; Kirchner, Robert; Engel, Carl D.

    2014-01-01

    The Space Launch System (SLS) base heating test is broken down into two test programs: (1) Pathfinder and (2) Main Test. The Pathfinder Test Program focuses on the design, development, hot-fire test and performance analyses of the 2% sub-scale SLS core-stage and booster element propulsion systems. The core-stage propulsion system is composed of four gaseous oxygen/hydrogen RS-25D model engines and the booster element is composed of two aluminum-based model solid rocket motors (SRMs). The first section of the paper discusses the motivation and test facility specifications for the test program. The second section briefly investigates the internal flow path of the design. The third section briefly shows the performance of the model RS-25D engines and SRMs for the conducted short duration hot-fire tests. Good agreement is observed based on design prediction analysis and test data. This program is a challenging research and development effort that has not been attempted in 40+ years for a NASA vehicle.

  11. A Review of Low Frequency Electromagnetic Wave Phenomena Related to Tropospheric-Ionospheric Coupling Mechanisms

    NASA Technical Reports Server (NTRS)

    Simoes, Fernando; Pfaff, Robert; Berthelier, Jean-Jacques; Klenzing, Jeffrey

    2012-01-01

    Investigation of coupling mechanisms between the troposphere and the ionosphere requires a multidisciplinary approach involving several branches of atmospheric sciences, from meteorology, atmospheric chemistry, and fulminology to aeronomy, plasma physics, and space weather. In this work, we review low frequency electromagnetic wave propagation in the Earth-ionosphere cavity from a troposphere-ionosphere coupling perspective. We discuss electromagnetic wave generation, propagation, and resonance phenomena, considering atmospheric, ionospheric and magnetospheric sources, from lightning and transient luminous events at low altitude to Alfven waves and particle precipitation related to solar and magnetospheric processes. We review in situ ionospheric processes as well as surface and space weather phenomena that drive troposphere-ionosphere dynamics. Effects of aerosols, water vapor distribution, thermodynamic parameters, and cloud charge separation and electrification processes on atmospheric electricity and electromagnetic waves are reviewed. We also briefly revisit ionospheric irregularities such as spread-F and explosive spread-F, sporadic-E, traveling ionospheric disturbances, Trimpi effect, and hiss and plasma turbulence. Regarding the role of the lower boundary of the cavity, we review transient surface phenomena, including seismic activity, earthquakes, volcanic processes and dust electrification. The role of surface and atmospheric gravity waves in ionospheric dynamics is also briefly addressed. We summarize analytical and numerical tools and techniques to model low frequency electromagnetic wave propagation and solving inverse problems and summarize in a final section a few challenging subjects that are important for a better understanding of tropospheric-ionospheric coupling mechanisms.

  12. Calculation of photoionization cross section near auto-ionizing lines and magnesium photoionization cross section near threshold

    NASA Technical Reports Server (NTRS)

    Moore, E. N.; Altick, P. L.

    1972-01-01

    The research performed is briefly reviewed. A simple method was developed for the calculation of continuum states of atoms when autoionization is present. The method was employed to give the first theoretical cross section for beryllium and magnesium; the results indicate that the values used previously at threshold were sometimes seriously in error. These threshold values have potential applications in astrophysical abundance estimates.

  13. Robust Optimization and Sensitivity Analysis with Multi-Objective Genetic Algorithms: Single- and Multi-Disciplinary Applications

    DTIC Science & Technology

    2007-01-01

    multi-disciplinary optimization with uncertainty. Robust optimization and sensitivity analysis is usually used when an optimization model has...formulation is introduced in Section 2.3. We briefly discuss several definitions used in the sensitivity analysis in Section 2.4. Following in...2.5. 2.4 SENSITIVITY ANALYSIS In this section, we discuss several definitions used in Chapter 5 for Multi-Objective Sensitivity Analysis . Inner

  14. Supply chain optimization: a practitioner's perspective on the next logistics breakthrough.

    PubMed

    Schlegel, G L

    2000-08-01

    The objective of this paper is to profile a practitioner's perspective on supply chain optimization and highlight the critical elements of this potential new logistics breakthrough idea. The introduction will briefly describe the existing distribution network, and business environment. This will include operational statistics, manufacturing software, and hardware configurations. The first segment will cover the critical success factors or foundations elements that are prerequisites for success. The second segment will give you a glimpse of a "working game plan" for successful migration to supply chain optimization. The final segment will briefly profile "bottom-line" benefits to be derived from the use of supply chain optimization as a strategy, tactical tool, and competitive advantage.

  15. Applications of Magnetic Suspension Technology to Large Scale Facilities: Progress, Problems and Promises

    NASA Technical Reports Server (NTRS)

    Britcher, Colin P.

    1997-01-01

    This paper will briefly review previous work in wind tunnel Magnetic Suspension and Balance Systems (MSBS) and will examine the handful of systems around the world currently known to be in operational condition or undergoing recommissioning. Technical developments emerging from research programs at NASA and elsewhere will be reviewed briefly, where there is potential impact on large-scale MSBSS. The likely aerodynamic applications for large MSBSs will be addressed, since these applications should properly drive system designs. A recently proposed application to ultra-high Reynolds number testing will then be addressed in some detail. Finally, some opinions on the technical feasibility and usefulness of a large MSBS will be given.

  16. Effects of thermal cycling on composite materials for space structures

    NASA Technical Reports Server (NTRS)

    Tompkins, Stephen S.

    1989-01-01

    The effects of thermal cycling on the thermal and mechanical properties of composite materials that are candidates for space structures are briefly described. The results from a thermal analysis of the orbiting Space Station Freedom is used to define a typical thermal environment and the parameters that cause changes in the thermal history. The interactions of this environment with composite materials are shown and described. The effects of this interaction on the integrity as well as the properties of GR/thermoset, Gr/thermoplastic, Gr/metal and Gr/glass composite materials are discussed. Emphasis is placed on the effects of the interaction that are critical to precision spacecraft. Finally, ground test methodology are briefly discussed.

  17. A Brief Overview of Adolescent Developmental Problems in Hong Kong

    PubMed Central

    Shek, Daniel T. L.; Keung Ma, Hing; Sun, Rachel C. F.

    2011-01-01

    Several adolescent developmental problems in Hong Kong are briefly reviewed in this paper. First, rising adolescent substance abuse trends are described. Second, Internet use problems and Internet addiction among young people are examined. Third, worrying trends in adolescent sexuality are identified. Fourth, phenomena on bullying among young people are reviewed. Finally, phenomena related to adolescent materialistic orientation are focused upon. With reference to these adolescent developmental problems, possible solutions are briefly discussed particularly with reference to the ecological perspective. It is argued that the related scientific literature provides useful pointers for designing the curriculum in the extension phase of the Project P.A.T.H.S. in Hong Kong. PMID:22194661

  18. Productivity Gainsharing--A Scanlon Overview.

    ERIC Educational Resources Information Center

    Kovac, James S.

    1986-01-01

    Provides an overview to an organization which is considering the initiation of a plan to share gains with its workers. Defines productivity, explains the benefits of improved productivity, examines a number of approaches to sharing productivity gains with workers, compares individual incentive plans with gain sharing plans, and finally, briefly,…

  19. The First Reactor, Understanding the Atom Series.

    ERIC Educational Resources Information Center

    Allardice, Corbin; And Others

    This booklet is one of the "Understanding the Atom" Series. Consisting of three sections, it is an account of the development of the first nuclear reactor by a team of scientists led by Enrico Farmi. The first section briefly reviews the early work on nuclear fission and neutron emission, the impact of Einstein's letter to President Roosevelt, the…

  20. Guide to Community-Based Rehabilitation Services. Guides for Special Education No. 8.

    ERIC Educational Resources Information Center

    O'Toole, Brian John

    This booklet is intended as an introductory guide to community-based rehabilitation (CBR) services in developing nations. The first section examines the magnitude of the problem; the failure of existing services to meet this challenge; and the need for a model appropriate to developing countries. The second section briefly describes the CBR…

  1. Use and Impact of Covariance Data in the Japanese Latest Adjusted Library ADJ2010 Based on JENDL-4.0

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yokoyama, K., E-mail: yokoyama.kenji09@jaea.go.jp; Ishikawa, M.

    2015-01-15

    The current status of covariance applications to fast reactor analysis and design in Japan is summarized. In Japan, the covariance data are mainly used for three purposes: (1) to quantify the uncertainty of nuclear core parameters, (2) to identify important nuclides, reactions and energy ranges which are dominant to the uncertainty of core parameters, and (3) to improve the accuracy of core design values by adopting the integral data such as the critical experiments and the power reactor operation data. For the last purpose, the cross section adjustment based on the Bayesian theorem is used. After the release of JENDL-4.0,more » a development project of the new adjusted group-constant set ADJ2010 was started in 2010 and completed in 2013. In the present paper, the final results of ADJ2010 are briefly summarized. In addition, the adjustment results of ADJ2010 are discussed from the viewpoint of use and impact of nuclear data covariances, focusing on {sup 239}Pu capture cross section alterations. For this purpose three kind of indices, called “degree of mobility,” “adjustment motive force,” and “adjustment potential,” are proposed.« less

  2. A project based on multi-configuration Dirac-Fock calculations for plasma spectroscopy

    NASA Astrophysics Data System (ADS)

    Comet, M.; Pain, J.-C.; Gilleron, F.; Piron, R.

    2017-09-01

    We present a project dedicated to hot plasma spectroscopy based on a Multi-Configuration Dirac-Fock (MCDF) code, initially developed by J. Bruneau. The code is briefly described and the use of the transition state method for plasma spectroscopy is detailed. Then an opacity code for local-thermodynamic-equilibrium plasmas using MCDF data, named OPAMCDF, is presented. Transition arrays for which the number of lines is too large to be handled in a Detailed Line Accounting (DLA) calculation can be modeled within the Partially Resolved Transition Array method or using the Unresolved Transition Arrays formalism in jj-coupling. An improvement of the original Partially Resolved Transition Array method is presented which gives a better agreement with DLA computations. Comparisons with some absorption and emission experimental spectra are shown. Finally, the capability of the MCDF code to compute atomic data required for collisional-radiative modeling of plasma at non local thermodynamic equilibrium is illustrated. In addition to photoexcitation, this code can be used to calculate photoionization, electron impact excitation and ionization cross-sections as well as autoionization rates in the Distorted-Wave or Close Coupling approximations. Comparisons with cross-sections and rates available in the literature are discussed.

  3. 300 Area waste acid treatment system closure plan. Revision 1

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1996-03-01

    This section provides a description of the Hanford Site, identifies the proposed method of 300 Area Waste Acid Treatment System (WATS) closure, and briefly summarizes the contents of each chapter of this plan.

  4. Morality is real, objective, and supernatural.

    PubMed

    Miller, Christian B

    2016-11-01

    The goal of this paper is to briefly introduce and defend the idea that God is the source of our moral obligations. In contrast to Michael Shermer's paper, which defends a naturalistic position about the foundations of morality, this approach is explicitly supernaturalistic. The paper begins by defining how "God" will be understood, and then spells out some of the details of how, on the proposed view, moral obligations are to depend upon God. The third section briefly reviews some of the leading arguments for this view, before the paper concludes with a discussion of the Euthyphro dilemma. © 2016 New York Academy of Sciences.

  5. The communicative functions of final rises in Finnish intonation.

    PubMed

    Ogden, Richard; Routarinne, Sara

    2005-01-01

    This paper considers the communicative function of final rises in Finnish conversational talk between pairs of teenage girls. Final rises are fairly common, occurring approximately twice a minute, predominantly on declaratives and in narrative sequences. We briefly consider the interplay between voice quality (known to be a marker of transition relevance) and rising intonation in Finnish. We argue that in narrative sequences, rising terminals manage two main interactional tasks: they provide a place for a coparticipant to mark recipiency, and they project more talk by the current speaker. Using a methodology which combines phonetic observation with conversation analysis, we demonstrate participants' orientation to these functions.

  6. Nuclear Medical Technology. Curriculum for a Two Year Program. Final Report.

    ERIC Educational Resources Information Center

    Buatti, A.; Rich, D.

    Objectives of the project briefly described here were (1) to develop curriculum for a two-year nuclear medical technology program based on a working relationship between three institutions (community college, university health center, and hospital) and (2) to develop procedures for the operation of a medical imaging and radiation technology core…

  7. Home Education: Practising without Prejudice?

    ERIC Educational Resources Information Center

    Rothermel, Paula Jane

    2010-01-01

    In this article has been extracted from a longer paper by the same name that came about in response to the Badman Review of Elective Home Education (Badman 2009). The first part briefly discusses the Badman Review. The next looks at the misunderstandings that can occur once concerns are raised in home education. Finally there are case studies…

  8. Human Factors Technologies: Past Promises, Future Issues. Final Technical Paper.

    ERIC Educational Resources Information Center

    Alluisi, Earl A.

    This discussion of the major issues confronting the human factors profession begins by pointing out that the concepts of systems and system design are central to the roles and functions of the human factors specialist. Three related disciplines--human factors engineering, ergonomics, and human skilled performance--are briefly described, and the…

  9. Research on aviation fuel instability

    NASA Technical Reports Server (NTRS)

    Baker, C. E.; Bittker, D. A.; Cohen, S. M.; Seng, G. T.

    1983-01-01

    The underlying causes of fuel thermal degradation are discussed. Topics covered include: nature of fuel instability and its temperature dependence, methods of measuring the instability, chemical mechanisms involved in deposit formation, and instrumental methods for characterizing fuel deposits. Finally, some preliminary thoughts on design approaches for minimizing the effects of lowered thermal stability are briefly discussed.

  10. Comments

    ERIC Educational Resources Information Center

    Ertmer, Peggy; Hlynka, Denis; Hung, David; Reeves, Thomas; Romiszowski, Alexander; Rose, Ellen

    2013-01-01

    As a final part of this special issue, six Contributing Editors of the magazine were asked to review the six articles and to briefly reflect on themes across fields, on ideas or areas that might have the most potential, and/or to offer other new ideas for our field that the articles and issue overall triggered. These senior scholars in our field…

  11. Ultrasonic Nondestructive Evaluation Techniques Applied to the Quantitative Characterization of Textile Composite Materials

    NASA Technical Reports Server (NTRS)

    Miller, James G.

    1997-01-01

    In this Progress Report, we describe our further development of advanced ultrasonic nondestructive evaluation methods applied to the characterization of anisotropic materials. We present images obtained from experimental measurements of ultrasonic diffraction patterns transmitted through water only and transmitted through water and a thin woven composite. All images of diffraction patterns have been included on the accompanying CD-ROM in the JPEG format and Adobe TM Portable Document Format (PDF), in addition to the inclusion of hardcopies of the images contained in this report. In our previous semi-annual Progress Report (NAG 1-1848, December, 1996), we proposed a simple model to simulate the effect of a thin woven composite on an insonifying ultrasonic pressure field. This initial approach provided an avenue to begin development of a robust measurement method for nondestructive evaluation of anisotropic materials. In this Progress Report, we extend that work by performing experimental measurements on a single layer of a five-harness biaxial woven composite to investigate how a thin, yet architecturally complex, material interacts with the insonifying ultrasonic field. In Section 2 of this Progress Report we describe the experimental arrangement and methods for data acquisition of the ultrasonic diffraction patterns upon transmission through a thin woven composite. We also briefly describe the thin composite specimen investigated. Section 3 details the analysis of the experimental data followed by the experimental results in Section 4. Finally, a discussion of the observations and conclusions is found in Section 5.

  12. A Review of Research Bearing on the Impact of Television and Motion Pictures on Children and Adults.

    ERIC Educational Resources Information Center

    Loye, David

    Research literature relating to the power of dramatic television or movie entertainment for value, attitude, and behavior change is reviewed. Section 1 of this paper covers the research literature bearing on the effects of mass entertainment on adults, adolescents, and children. Section 2 briefly describes the research needs to be addressed by the…

  13. Technical Application of Nuclear Fission

    NASA Astrophysics Data System (ADS)

    Denschlag, J. O.

    The chapter is devoted to the practical application of the fission process, mainly in nuclear reactors. After a historical discussion covering the natural reactors at Oklo and the first attempts to build artificial reactors, the fundamental principles of chain reactions are discussed. In this context chain reactions with fast and thermal neutrons are covered as well as the process of neutron moderation. Criticality concepts (fission factor η, criticality factor k) are discussed as well as reactor kinetics and the role of delayed neutrons. Examples of specific nuclear reactor types are presented briefly: research reactors (TRIGA and ILL High Flux Reactor), and some reactor types used to drive nuclear power stations (pressurized water reactor [PWR], boiling water reactor [BWR], Reaktor Bolshoi Moshchnosti Kanalny [RBMK], fast breeder reactor [FBR]). The new concept of the accelerator-driven systems (ADS) is presented. The principle of fission weapons is outlined. Finally, the nuclear fuel cycle is briefly covered from mining, chemical isolation of the fuel and preparation of the fuel elements to reprocessing the spent fuel and conditioning for deposit in a final repository.

  14. National ITS architecture transit guidelines : executive summary

    DOT National Transportation Integrated Search

    1997-01-01

    This booklet is intended for transit board members and senior management. It provides general information on ITS and the National ITS Architecture with respect to transit, and highlights the benefits of each. Section 2 briefly discusses the Intermoda...

  15. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bustraan, M.; Coehoorn, J.; Veenema, J.J.

    This report is a collection of separate contributions on some aspects of the work done on STEK up to February 1970. A description is given of STEK together with the philosophy of its design, i.e. integral measurements of fission product cross sections by a sample oscillator technique in fast reactor spectra. The influences fission products may have on fast breeder reactors are briefly demonstrated by an example. A description of the facility and of the sample oscillator and sample exchange mechanism is given. Some preliminary results of measurements of reactor parameters and the neutron spectrum in the first fast zonemore » in STEK are given. For the use of lead as material for the buffer an argumentation is given. The proposed program for the measurements of the integral fission product cross sections is outlined. The procurement of some, highly active, samples of actual fission products is briefly sketched. (auth)« less

  16. General Climatology 3

    NASA Astrophysics Data System (ADS)

    Hartmann, Dennis L.

    General Climatology 3 is volume 3 of the series World Survey of Climatology, which consists of 15 volumes containing review articles on a broad range of topics. General Climatology 3 contains four chapters: ‘Human Bioclimatology,’ ‘Agricultural Climatology,’ ‘City Climate,’ and ‘Technical Climatology.’ Each of these chapters will be briefly described here.‘Human Bioclimatology,’ the first chapter, was authored by E. Flach and provides a survey of the effects on the human organism of the physical conditions at the earth's surface. It contains four main sections. A section entitled ‘Light and Life’ deals with the effects of solar radiation on man and contains much interesting information on the response of the human eye and human skin to radiation at various frequencies. ‘Air and Life’ discusses the composition of air and its effect on human health and performance, including discussions of the effects of altitude, aerosols, and noxious trace gases. ‘Temperature and Life’ discusses how the body responds to temperature and how it maintains its heat budget under the variety of conditions to which it falls subject and considerable discussion is given to objective ways to characterize air conditions that give an accurate measure of their impact on the body. This discussion leads naturally into the final section, ‘Bioclimatological Evaluation Systems,’ which addresses the problem of how to classify a particular site according to its overall suitability to human habitation.

  17. ITS deployment guidance for transit systems : executive edition

    DOT National Transportation Integrated Search

    1997-04-01

    This booklet is intended for transit board members and senior management. It provides general information on ITS and the National ITS Architecture with respect to transit, and highlights the benefits of each. Section 2 briefly discusses the Intermoda...

  18. Weaning Foods.

    ERIC Educational Resources Information Center

    Chauliac, Michel; And Others

    1987-01-01

    Described in this issue of "Children in the Tropics" are handicraft, semi-industrial, and industrial projects which produce weaning foods in developing countries. The introductory section briefly discusses the global epidemiology of malnutrition and offers guidelines for combatting malnutrition. Chapter I provides a framework for…

  19. [The Concept and Treatment of Internet Addiction].

    PubMed

    Elsalhy, Muhammad; Muramatsu, Taro; Higuchi, Susumu; Mimura, Masaru

    2016-10-01

    The Internet now plays a very important role in our lives. However, for some people, Internet use can lead to a state that appears to meet the DSM definition for a mental disorder. In this review, we briefly discuss definition, symptoms, risk factors, prevalence, comorbidities, and personality traits of people who are susceptible to becoming addicts. In the second section of the article, various types of Internet addiction are discussed, focusing mainly on Internet Gaming Disorder and social networking survices (SNS) addiction. Regarding Internet Gaming Disorder, we discuss various types of the newly emerged Massive Multiplayer Online Games (MMO), as well as theories about why people become addicted to them. We do the same for the SNS Addiction for sites like Facebook and LINE; again, different types, as well as theories about why some people become addicts to such sites are discussed. Finally, preventive measures are introduced, focusing on a number of commonly used treatment methods, perticulary cognitive behavioral therapy and family therapy.

  20. Biomimetic materials for controlling bone cell responses.

    PubMed

    Drevelle, Olivier; Faucheux, Nathalie

    2013-01-01

    Bone defects that cannot "heal spontaneously during life" will become an ever greater health problem as populations age. Harvesting autografts has several drawbacks, such as pain and morbidity at both donor and acceptor sites, the limited quantity of material available, and frequently its inappropriate shape. Researchers have therefore developed alternative strategies that involve biomaterials to fill bone defects. These biomaterials must be biocompatible and interact with the surrounding bone tissue to allow their colonization by bone cells and blood vessels. The latest generation biomaterials are not inert; they control cell responses like adhesion, proliferation and differentiation. These biomaterials are called biomimetic materials. This review focuses on the development of third generation materials. We first briefly describe the bone tissue with its cells and matrix, and then how bone cells interact with the extracellular matrix. The next section covers the materials currently used to repair bone defects. Finally, we describe the strategies employed to modify the surface of materials, such as coating with hydroxyapatite and grafting biomolecules.

  1. Current strategies in multiphasic scaffold design for osteochondral tissue engineering: A review.

    PubMed

    Yousefi, Azizeh-Mitra; Hoque, Md Enamul; Prasad, Rangabhatala G S V; Uth, Nicholas

    2015-07-01

    The repair of osteochondral defects requires a tissue engineering approach that aims at mimicking the physiological properties and structure of two different tissues (cartilage and bone) using specifically designed scaffold-cell constructs. Biphasic and triphasic approaches utilize two or three different architectures, materials, or composites to produce a multilayered construct. This article gives an overview of some of the current strategies in multiphasic/gradient-based scaffold architectures and compositions for tissue engineering of osteochondral defects. In addition, the application of finite element analysis (FEA) in scaffold design and simulation of in vitro and in vivo cell growth outcomes has been briefly covered. FEA-based approaches can potentially be coupled with computer-assisted fabrication systems for controlled deposition and additive manufacturing of the simulated patterns. Finally, a summary of the existing challenges associated with the repair of osteochondral defects as well as some recommendations for future directions have been brought up in the concluding section of this article. © 2014 Wiley Periodicals, Inc.

  2. Moly99 Production Facility: Report on Beamline Components, Requirements, Costs

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bishofberger, Kip A.

    2015-12-23

    In FY14 we completed the design of the beam line for the linear accelerator production design concept. This design included a set of three bending magnets, quadrupole focusing magnets, and octopoles to flatten the beam on target. This design was generic and applicable to multiple different accelerators if necessary. In FY15 we built on that work to create specifications for the individual beam optic elements, including power supply requirements. This report captures the specification of beam line components with initial cost estimates for the NorthStar production facility.This report is organized as follows: The motivation of the beamline design is introducedmore » briefly, along with renderings of the design. After that, a specific list is provided, which accounts for each beamline component, including part numbers and costs, to construct the beamline. After that, this report details the important sections of the beamline and individual components. A final summary and list of follow-on activities completes this report.« less

  3. "Clinical brain profiling": a neuroscientific diagnostic approach for mental disorders.

    PubMed

    Peled, Abraham; Geva, Amir B

    2014-10-01

    Clinical brain profiling is an attempt to map a descriptive nosology in psychiatry to underlying constructs in neurobiology and brain dynamics. This paper briefly reviews the motivation behind clinical brain profiling (CBP) and presents some provisional validation using clinical assessments and meta-analyses of neuroscientific publications. The paper has four sections. In the first, we review the nature and motivation for clinical brain profiling. This involves a description of the key aspects of functional anatomy that can lead to psychopathology. These features constitute the dimensions or categories for a profile of brain disorders based upon pathophysiology. The second section describes a mapping or translation matrix that maps from symptoms and signs, of a descriptive sort, to the CBP dimensions that provide a more mechanistic explanation. We will describe how this mapping engenders archetypal diagnoses, referring readers to tables and figures. The third section addresses the construct validity of clinical brain profiling by establishing correlations between profiles based on clinical ratings of symptoms and signs under classical diagnostic categories with the corresponding profiles generated automatically using archetypal diagnoses. We then provide further validation by performing a cluster analysis on the symptoms and signs and showing how they correspond to the equivalent brain profiles based upon clinical and automatic diagnosis. In the fourth section, we address the construct validity of clinical brain profiling by looking for associations between pathophysiological mechanisms (such as connectivity and plasticity) and nosological diagnoses (such as schizophrenia and depression). Based upon the mechanistic perspective offered in the first section, we test some particular hypotheses about double dissociations using a meta-analysis of PubMed searches. The final section concludes with perspectives for the future and outstanding validation issues for clinical brain profiling. Copyright © 2014 Elsevier Ltd. All rights reserved.

  4. RHCV Telescope System Operations Manual

    DTIC Science & Technology

    2018-01-05

    hardware and software components. Several of the components are closely coupled and rely on one-another, while others are largely independent. This...of hardware and software components. Several of the components are closely coupled and rely on one-another, while others are largely independent. This...attendant training The use cases are briefly described in separate sections, and step-by-step instructions are presented. Each section begins on a new

  5. India: A Land of Contrasts. How to Develop Pro-Active Action Student Awareness and Understanding about the Third World in South Asia.

    ERIC Educational Resources Information Center

    Peters, Richard O.

    This document presents a critical thinking/decision-making model to help students in grades K-12 understand East Indian culture. It is divided into three sections. Section 1 provides background information about India from the 15th century BC to the present. It briefly discusses religion, independence, political organization, social institutions,…

  6. Perspectives in patent law: overview, careers, and controversies.

    PubMed

    Davis, Clara

    2009-01-01

    This paper is directed to scientists and engineers who wish to learn more about careers in patent law. It presents an overview of the patent process along with a description of the various roles of individuals and institutions involved. Finally, the paper briefly discusses a few of the more controversial issues in the patent law field today.

  7. 75 FR 11107 - Revision of Land Management Plan for the George Washington National Forest, Virginia and West...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-10

    ... additional information. Finally, this notice briefly describes the applicable planning rule and how work done..., or recorded at past public meetings, related to the revision of the GW Forest Plan since 2007 will be..., environmental stresses and threats, societal demands and our current state of scientific knowledge. Also since...

  8. The BCR signalosome: where cell fate is decided.

    PubMed

    Ulivieri, C; Baldari, C T

    2005-01-01

    B cell antigen receptor (BCR) engagement results in the assembly of a multimolecular complex at the cytosolic side of the plasma membrane, known as signalosome. Here we briefly review the current knowledge on the molecules which participate in the BCR signalosome and on the response modulators which control the final signal output by enhancing or dampening BCR signaling.

  9. Preliminary low-level waste feed definition guidance - LLW pretreatment interface

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Shade, J.W.; Connor, J.M.; Hendrickson, D.W.

    1995-02-01

    The document describes limits for key constituents in the LLW feed, and the bases for these limits. The potential variability in the stream is then estimated and compared to the limits. Approaches for accomodating uncertainty in feed inventory, processing strategies, and process design (melter and disposal system) are discussed. Finally, regulatory constraints are briefly addressed.

  10. Pilot Test of the Online Public Access Catalog Project's User and Nonuser Questionnaires. Final Report.

    ERIC Educational Resources Information Center

    Markey, Karen

    This report describes the pilot data collections and post-questionnaire interview activities of the Council on Library Resources (CLR)/Online Computer Library Center (OCLC) Online Public Access Project. The background of the project is briefly described, the purpose and adminstration of the post-questionnaire interviews are outlined, and pilot…

  11. Apollo 11: A good ending to a bad decade

    NASA Technical Reports Server (NTRS)

    1979-01-01

    The Gemini program and the Apollo program which culminated in landing a man on the moon and safely returning him to earth are highlighted. The space program in the aftermath of Apollo 11 is briefly summarized, including: Skylab, Apollo Soyuz, Mars and Venus probes, improved world communications, remote sensing of world resources, and finally, space shuttle.

  12. Models and Procedures for Improving the Planning, Management, and Evaluation of Cooperative Education Programs. Final Report. Volume I.

    ERIC Educational Resources Information Center

    Blaschke, Charles L.; Steiger, JoAnn

    This report of a project to design a set of training guidelines for planning, managing, and evaluating cooperative education programs describes briefly the procedures used in developing the guidelines and model; discusses the various components of the planning, management, and evaluation process; and presents guidelines and criteria for designing…

  13. Enriched uranium imports into the EEC countries in 1972 (in German)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    1973-11-01

    Parts of a survey published by the statistical Office of the European Communities, entitled ''The Supply of the ECC Countries with Enriched Uranium'' are given and briefly commented on. The main daia and figures on the final utilization of the enriched uranium imported by the EEC countries in 1972 are shown in tabular form. (GE)

  14. Photoelectron Diffraction from Valence States of Oriented Molecules

    NASA Astrophysics Data System (ADS)

    Krüger, Peter

    2018-06-01

    The angular distribution of photoelectrons emitted from valence states of oriented molecules is investigated. The principles underlying the angular pattern formation are explained in terms of photoelectron wave interference, caused by initial state delocalization and final state photoelectron scattering. Computational approaches to photoelectron spectroscopy from molecules are briefly reviewed. Here a combination of molecular orbital calculations for the initial state and multiple scattering theory for the photoelectron final state is used and applied to the 3σ and 4σ orbitals of nitrogen and the highest occupied molecular orbital of pentacene. Appreciable perpendicular emission and circular dichroism in angular distributions is found, two effects that cannot be described by the popular plane wave approximation to the photoelectron final state.

  15. About various definitions of life.

    PubMed

    Luisi, P L

    1998-10-01

    The old question of a definition of minimal life is taken up again at the aim of providing a forum for an updated discussion. Briefly discussed are the reasons why such an attempt has previously encountered scepticism, and why such an attempt should be renewed at this stage of the inquiry on the origin of life. Then some of the definitions of life presently used are cited and briefly discussed, starting with the definition adopted by NASA as a general working definition. It is shown that this is too limited if one wishes to provide a broad encompassing definition, and some extensions of it are presented and discussed. Finally it is shown how the different definitions of life reflect the main schools of thought that presently dominate the field on the origin of life.

  16. WIMP dark matter candidates and searches-current status and future prospects.

    PubMed

    Roszkowski, Leszek; Sessolo, Enrico Maria; Trojanowski, Sebastian

    2018-06-01

    We review several current aspects of dark matter theory and experiment. We overview the present experimental status, which includes current bounds and recent claims and hints of a possible signal in a wide range of experiments: direct detection in underground laboratories, gamma-ray, cosmic ray, x-ray, neutrino telescopes, and the LHC. We briefly review several possible particle candidates for a weakly interactive massive particle (WIMP) and dark matter that have recently been considered in the literature. We pay particular attention to the lightest neutralino of supersymmetry as it remains the best motivated candidate for dark matter and also shows excellent detection prospects. Finally we briefly review some alternative scenarios that can considerably alter properties and prospects for the detection of dark matter obtained within the standard thermal WIMP paradigm.

  17. WIMP dark matter candidates and searches—current status and future prospects

    NASA Astrophysics Data System (ADS)

    Roszkowski, Leszek; Sessolo, Enrico Maria; Trojanowski, Sebastian

    2018-06-01

    We review several current aspects of dark matter theory and experiment. We overview the present experimental status, which includes current bounds and recent claims and hints of a possible signal in a wide range of experiments: direct detection in underground laboratories, gamma-ray, cosmic ray, x-ray, neutrino telescopes, and the LHC. We briefly review several possible particle candidates for a weakly interactive massive particle (WIMP) and dark matter that have recently been considered in the literature. We pay particular attention to the lightest neutralino of supersymmetry as it remains the best motivated candidate for dark matter and also shows excellent detection prospects. Finally we briefly review some alternative scenarios that can considerably alter properties and prospects for the detection of dark matter obtained within the standard thermal WIMP paradigm.

  18. Nurse Education Act of 1985. Report Together with Additional Views to Accompany H.R. 2370. House of Representatives, Ninety-ninth Congress, First Session.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House Committee on Energy and Commerce.

    A bill amending the Public Health Service Act (Title VIII) to extend programs of assistance for nurse education is addressed in this congressional report. After briefly reviewing the background and need for the legislation, a section-by-section analysis is presented. H.R. 2370 extends for 3 years the following programs in nurse education: special…

  19. Elementary School Finance Manual.

    ERIC Educational Resources Information Center

    National Catholic Educational Association, Washington, DC.

    Developed to assist those responsible for financial matters in Catholic elementary schools, this manual presents each topic briefly and simply, taking into account administrators' minimal formal financial training. It is divided into six sections. Chapter 1, "Daily Financial Operations," describes the specifics of handling receipts, billings, and…

  20. Information for the Graduate.

    ERIC Educational Resources Information Center

    Montgomery County Public Schools, Rockville, MD. Dept. of Special Education and Related Services.

    This booklet for graduates of special education programs in Montgomery County, Maryland, briefly describes and lists local resources for further education, work opportunities, recreation, and health/safety. The first section provides information on being independent and covers school records, social security cards, armed services registration,…

  1. Jung and Kabbalah: imaginal and noetic aspects.

    PubMed

    Joseph, Steven M

    2007-06-01

    Jung made use of kabbalistic images and motifs in various parts of his opus, including in his alchemical studies, in Aion, and extensively in Mysterium Coniunctionis. He also recorded an important dream after his heart attack which made use of kabbalistic symbolism in Memories, Dreams, Reflections. In this paper I explore Jung's ideas in relation to Kabbalah, first, by differentiating between Jung's imaginal approach to kabbalistic symbolism and the noetic intention of the Kabbalah itself in its use of imaginal material. Second, I present a number of typical examples of how Jung understands (and sometimes misunderstands) kabbalistic material that he cites. Third, I briefly survey the development of the Kabbalah as an imaginal noetic system, and present a core self-understanding of kabbalists--as engaged in inner 'self-work' which intends to 'sweeten the harsh judgments of existence in their very roots'. Finally, I differentiate Jung's understanding of the psychical living symbol from the kabbalistic understanding of the mystical symbol. In this fourth section of the paper, I conclude by presenting a basic Hasidic/kabbalistic teaching on the nature and function of verbal contemplative prayer--as an illustration of the difference between the two understandings of symbolism. The four sections of the paper are framed by a 'Prelude' and a 'Coda'.

  2. Recent advances in lossless coding techniques

    NASA Astrophysics Data System (ADS)

    Yovanof, Gregory S.

    Current lossless techniques are reviewed with reference to both sequential data files and still images. Two major groups of sequential algorithms, dictionary and statistical techniques, are discussed. In particular, attention is given to Lempel-Ziv coding, Huffman coding, and arithmewtic coding. The subject of lossless compression of imagery is briefly discussed. Finally, examples of practical implementations of lossless algorithms and some simulation results are given.

  3. Home, School, and the IEP. ESEA Title IV Part C Project Report, Final Evaluation Report, 1981-82.

    ERIC Educational Resources Information Center

    New York City Board of Education, Brooklyn, NY. Office of Educational Evaluation.

    The "Home, School and the IEP (Individualized Education Program)" program was developed in order to provide counseling and training to the parents of autistic children in public schools in Brooklyn, New York, and to improve the behavior and achievement of the children themselves. This report briefly describes and evaluates the program in…

  4. Overview of recent aero-optics flight tests

    NASA Technical Reports Server (NTRS)

    Otten, L. J., III

    1980-01-01

    A chronological overview of aero-optics test flights is presented highlighting the objectives and conclusions from the tests. Flight tests performed in coordination with the PRESS reentry observation missions and the ALL Cycle 2 laser propagation and tracking demonstrations are described addressing the identification and quantification of distortion phenomena. Finally, current aero-optics flight investigations of an atmospheric turbulence probe are briefly discussed.

  5. Current Realities and Future Possibilities: Language and Science Literacy--Empowering Research and Informing Instruction

    ERIC Educational Resources Information Center

    Yore, Larry D.; Treagust, David F.

    2006-01-01

    In this final article, we briefly review and synthesize the science and language research and practice that arose from the current literature and presentations at an international conference, referred to as the first "Island Conference". We add to the synthesis of the articles the conference deliberations and on-going discussions of the field and…

  6. Expectancy Theory Modeling

    DTIC Science & Technology

    1982-08-01

    accomplish the task, (2) the instrumentality of task performance for job outcomes, and (3) the instrumentality of outcomes for need satisfaction . We...in this discussion: effort, performance , outcomes, and needs. In order to present briefly the conventional approach to the Vroom models, another...Presumably, this is the final event in the sequence of effort, performance , outcome, and need satisfaction . The actual research reported in expectancy

  7. Simulation of planetary entry radiative heating with a CO2 gasdynamic laser

    NASA Technical Reports Server (NTRS)

    Lundell, J. H.; Dickey, R. R.; Howe, J. T.

    1975-01-01

    Heating encountered during entry into the atmospheres of Jupiter, Saturn, and Uranus is described, followed by a discussion of the use of a CO2 gasdynamic laser to simulate the radiative component of the heating. Operation and performance of the laser is briefly described. Finally, results of laser tests of some candidate heat-shield materials are presented.

  8. Environmental concerns and international migration.

    PubMed

    Hugo, G

    1996-01-01

    "This article focuses on international migration occurring as a result of environmental changes and processes. It briefly reviews attempts to conceptualize environment-related migration and then considers the extent to which environmental factors have been and may be significant in initiating migration. Following is an examination of migration as an independent variable in the migration-environment relationship. Finally, ethical and policy dimensions are addressed."

  9. Spatial Double Generalized Beta Regression Models: Extensions and Application to Study Quality of Education in Colombia

    ERIC Educational Resources Information Center

    Cepeda-Cuervo, Edilberto; Núñez-Antón, Vicente

    2013-01-01

    In this article, a proposed Bayesian extension of the generalized beta spatial regression models is applied to the analysis of the quality of education in Colombia. We briefly revise the beta distribution and describe the joint modeling approach for the mean and dispersion parameters in the spatial regression models' setting. Finally, we motivate…

  10. Modifications to the Langley 8-foot transonic pressure tunnel for the laminar flow control experiment

    NASA Technical Reports Server (NTRS)

    Harris, Charles D.; Brooks, Cuyler W., Jr.

    1988-01-01

    Modifications to the NASA Langley 8 Foot Transonic Pressure Tunnel in support of the Lamina Flow Control (LFC) Experiment included the installation of a honeymoon and five screens in the settling chamber upstream of the test section 41-long test section liner that extended from the upstream end of the test section contraction region, through the best section, and into the diffuser. The honeycomb and screens were installed as permanent additions to the facility, and the liner was a temporary addition to be removed at the conclusion of the LFC Experiment. These modifications are briefly described.

  11. Behavioral medicine: a voyage to the future.

    PubMed

    Keefe, Francis J

    2011-04-01

    This paper discusses trends and future directions in behavioral medicine. It is divided into three sections. The first briefly reviews key developments in the history of behavioral medicine. The second section highlights trends and future directions in pain research and practice as a way of illustrating future directions for behavioral medicine. Consistent with the biopsychosocial model of pain, this section focuses on trends and future directions in three key areas: biological, psychological, and social. The third section describes recent Society of Behavioral Medicine initiatives designed to address some of the key challenges facing our field as we prepare for the future.

  12. Path planning and Ground Control Station simulator for UAV

    NASA Astrophysics Data System (ADS)

    Ajami, A.; Balmat, J.; Gauthier, J.-P.; Maillot, T.

    In this paper we present a Universal and Interoperable Ground Control Station (UIGCS) simulator for fixed and rotary wing Unmanned Aerial Vehicles (UAVs), and all types of payloads. One of the major constraints is to operate and manage multiple legacy and future UAVs, taking into account the compliance with NATO Combined/Joint Services Operational Environment (STANAG 4586). Another purpose of the station is to assign the UAV a certain degree of autonomy, via autonomous planification/replanification strategies. The paper is organized as follows. In Section 2, we describe the non-linear models of the fixed and rotary wing UAVs that we use in the simulator. In Section 3, we describe the simulator architecture, which is based upon interacting modules programmed independently. This simulator is linked with an open source flight simulator, to simulate the video flow and the moving target in 3D. To conclude this part, we tackle briefly the problem of the Matlab/Simulink software connection (used to model the UAV's dynamic) with the simulation of the virtual environment. Section 5 deals with the control module of a flight path of the UAV. The control system is divided into four distinct hierarchical layers: flight path, navigation controller, autopilot and flight control surfaces controller. In the Section 6, we focus on the trajectory planification/replanification question for fixed wing UAV. Indeed, one of the goals of this work is to increase the autonomy of the UAV. We propose two types of algorithms, based upon 1) the methods of the tangent and 2) an original Lyapunov-type method. These algorithms allow either to join a fixed pattern or to track a moving target. Finally, Section 7 presents simulation results obtained on our simulator, concerning a rather complicated scenario of mission.

  13. 17 CFR 229.1117 - (Item 1117) Legal proceedings.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 2 2011-04-01 2011-04-01 false (Item 1117) Legal proceedings. 229.1117 Section 229.1117 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION....1117 (Item 1117) Legal proceedings. Describe briefly any legal proceedings pending against the sponsor...

  14. 17 CFR 229.1117 - (Item 1117) Legal proceedings.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 2 2013-04-01 2013-04-01 false (Item 1117) Legal proceedings. 229.1117 Section 229.1117 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION....1117 (Item 1117) Legal proceedings. Describe briefly any legal proceedings pending against the sponsor...

  15. 17 CFR 229.1117 - (Item 1117) Legal proceedings.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 3 2014-04-01 2014-04-01 false (Item 1117) Legal proceedings. 229.1117 Section 229.1117 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION....1117 (Item 1117) Legal proceedings. Describe briefly any legal proceedings pending against the sponsor...

  16. 17 CFR 229.1117 - (Item 1117) Legal proceedings.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false (Item 1117) Legal proceedings. 229.1117 Section 229.1117 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION....1117 (Item 1117) Legal proceedings. Describe briefly any legal proceedings pending against the sponsor...

  17. Future Applications of Electronic Technology to Education.

    ERIC Educational Resources Information Center

    Lewis, Arthur J.; And Others

    Developments in electronic technology that have improved and linked together telecommunication and computers are discussed, as well as their use in instruction, implications of this use, and associated issues. The first section briefly describes the following developments: microcomputers and microprocessors, bubble memory, lasers, holography,…

  18. Final Results from Mexnext-I: Analysis of detailed aerodynamic measurements on a 4.5 m diameter rotor placed in the large German Dutch Wind Tunnel DNW

    NASA Astrophysics Data System (ADS)

    Schepers, J. G.; Boorsma, K.; Munduate, X.

    2014-12-01

    The paper presents the final results from the first phase of IEA Task 29 'Mexnext'. Mexnext was a joint project in which 20 parties from 11 different countries cooperated. The main aim of Mexnext was to analyse the wind tunnel measurements which have been taken in the EU project 'MEXICO'. In the MEXICO project 10 institutes from 6 countries cooperated in doing experiments on an instrumented, 3 bladed wind turbine of 4.5 m diameter placed in the 9.5 by 9.5 m2 open section of the Large Low-speed Facility (LLF) of DNW in the Netherlands. Pressure distributions on the blades were obtained from 148 Kulite pressure sensors, distributed over 5 sections at 25, 35, 60, 82 and 92 % radial position respectively. Blade loads were monitored through two strain-gauge bridges at each blade root. Most interesting however are the extensive PIV flow field measurements, which have been taken simultaneously with the pressure and load measurements. As a result of the international collaboration within this task a very thorough analysis of the data could be carried out and a large number of codes were validated not only in terms of loads but also in terms of underlying flow field. The paper will present several results from Mexnext-I, i.e. validation results and conclusion on modelling deficiencies and directions for model improvement. The future plans of the Mexnext consortium are also briefly discussed. Amongst these are Mexnext-II, a project in which also aerodynamic measurements other than MEXICO are included, and 'New MEXICO' in which additional measurement on the MEXICO model are performed.

  19. Design of a Ku band miniature multiple beam klystron

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bandyopadhyay, Ayan Kumar, E-mail: ayan.bandyopadhyay@gmail.com; Pal, Debasish; Kant, Deepender

    2016-03-09

    The design of a miniature multiple beam klystron (MBK) working in the Ku-band frequency range is presented in this article. Starting from the main design parameters, design of the electron gun, the input and output couplers and radio frequency section (RF-section) are presented. The design methodology using state of the art commercial electromagnetic design tools, analytical formulae as well as noncommercial design tools are briefly presented in this article.

  20. Simulation of Liquid Droplet in Air and on a Solid Surface

    NASA Astrophysics Data System (ADS)

    Launglucknavalai, Kevin

    Although multiphase gas and liquid phenomena occurs widely in engineering problems, many aspects of multiphase interaction like within droplet dynamics are still not quantified. This study aims to qualify the Lattice Boltzmann (LBM) Interparticle Potential multiphase computational method in order to build a foundation for future multiphase research. This study consists of two overall sections. The first section in Chapter 2 focuses on understanding the LBM method and Interparticle Potential model. It outlines the LBM method and how it relates to macroscopic fluid dynamics. The standard form of LBM is obtained. The perturbation solution obtaining the Navier-Stokes equations from the LBM equation is presented. Finally, the Interparticle Potential model is incorporated into the numerical LBM method. The second section in Chapter 3 presents the verification and validation cases to confirm the behavior of the single-phase and multiphase LBM models. Experimental and analytical results are used briefly to compare with numerical results when possible using Poiseuille channel flow and flow over a cylinder. While presenting the numerical results, practical considerations like converting LBM scale variables to physical scale variables are considered. Multiphase results are verified using Laplaces law and artificial behaviors of the model are explored. In this study, a better understanding of the LBM method and Interparticle Potential model is gained. This allows the numerical method to be used for comparison with experimental results in the future and provides a better understanding of multiphase physics overall.

  1. The 2016 Bowman Lecture Conjunctival curses: scarring conjunctivitis 30 years on

    PubMed Central

    Dart, J K

    2017-01-01

    This review is in two sections. The first section summarises 35 conditions, both common and infrequent, causing cicatrising conjunctivitis. Guidelines for making a diagnosis are given together with the use of diagnostic tests, including direct and indirect immunofluorescence, and their interpretation. The second section evaluates our knowledge of ocular mucous membrane pemphigoid, which is the commonest cause of cicatrizing conjunctivitis in most developed countries. The clinical characteristics, demographics, and clinical signs of the disease are described. This is followed by a review and re-evaluation of the pathogenesis of conjunctival inflammation in mucous membrane pemphigoid (MMP), resulting in a revised hypothesis of the autoimmune mechanisms causing inflammation in ocular MMP. The relationship between inflammation and scarring in MMP conjunctiva is described. Recent research, describing the role of aldehyde dehydrogenase (ALDH) and retinoic acid (RA) in both the initiation and perpetuation of profibrotic activity in MMP conjunctival fibroblasts is summarised and the potential for antifibrotic therapy, using ALDH inhibition, is discussed. The importance of the management of the ocular surface in MMP is briefly summarised. This is followed with the rationale for the use of systemic immunomodulatory therapy, currently the standard of care for patients with active ocular MMP. The evidence for the use of these drugs is summarised and guidelines given for their use. Finally, the areas for research and innovation in the next decade are reviewed including the need for better diagnostics, markers of disease activity, and the potential for biological and topical therapies for both inflammation and scarring. PMID:28106896

  2. Proteomics: a new approach to the study of disease.

    PubMed

    Chambers, G; Lawrie, L; Cash, P; Murray, G I

    2000-11-01

    The global analysis of cellular proteins has recently been termed proteomics and is a key area of research that is developing in the post-genome era. Proteomics uses a combination of sophisticated techniques including two-dimensional (2D) gel electrophoresis, image analysis, mass spectrometry, amino acid sequencing, and bio-informatics to resolve comprehensively, to quantify, and to characterize proteins. The application of proteomics provides major opportunities to elucidate disease mechanisms and to identify new diagnostic markers and therapeutic targets. This review aims to explain briefly the background to proteomics and then to outline proteomic techniques. Applications to the study of human disease conditions ranging from cancer to infectious diseases are reviewed. Finally, possible future advances are briefly considered, especially those which may lead to faster sample throughput and increased sensitivity for the detection of individual proteins. Copyright 2000 John Wiley & Sons, Ltd.

  3. Futurepath: The Story of Research and Technology at NASA Lewis Research Center. Structures for Flight Propulsion, ARC Sprayed Monotape, National Aero-Space Plane

    NASA Technical Reports Server (NTRS)

    1989-01-01

    The story of research and technology at NASA Lewis Research Center's Structures Division is presented. The job and designs of the Structures Division needed for flight propulsion is described including structural mechanics, structural dynamics, fatigue, and fracture. The video briefly explains why properties of metals used in structural mechanics need to be tested. Examples of tests and simulations used in structural dynamics (bodies in motion) are briefly described. Destructive and non-destructive fatigue/fracture analysis is also described. The arc sprayed monotape (a composite material) is explained, as are the programs in which monotape plays a roll. Finally, the National Aero-Space Plane (NASP or x-30) is introduced, including the material development and metal matrix as well as how NASP will reduce costs for NASA.

  4. Latin Curriculum Standards. Revised.

    ERIC Educational Resources Information Center

    Delaware State Dept. of Public Instruction, Dover.

    Delaware's state standards for the Latin curriculum in the public schools are presented. An introductory section outlines the goals of the Latin program for reading, cultural awareness, grammar, writing, and oral language and briefly discusses the philosophy of and approaches to Latin instruction in elementary and middle schools. Three subsequent…

  5. Health and Safety Research Division progress report, April 1, 1981-September 30, 1982

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1983-02-01

    Research progress for the reporting period is briefly summarized for the following sections: (1) health studies, (2) technology assessments, (3) biological and radiation physics, (4) chemical physics, (5) Office of Risk Analysis, and (6) health and environmental risk and analysis. (ACR)

  6. Guide for Organizing and Utilizing Local Vocational Education Advisory Councils.

    ERIC Educational Resources Information Center

    Alabama State Dept. of Education, Montgomery. Div. of Vocational Education.

    This handbook is designed to provide local administrators with both information and guidelines for organizing, implementing, and operating local vocational education advisory councils. Following a short introduction, there is a section which briefly discusses the procedures for organizing an advisory council: formulate policy, designate school…

  7. Library Binding Manual. Revised Edition.

    ERIC Educational Resources Information Center

    Lakhanpal, S. K.

    This procedural manual is designed to be used in bindery sections in public, university and special libraries. It briefly discusses these general matters: administrative control; selection of a binder; when and what to bind; conventional binding; routines; missing issues; schedule for shipments; temporary binding; rare books, maps and newspapers;…

  8. Relationship of Neurocognitive Function to Breast Cancer Treatment and Induced Menopause

    DTIC Science & Technology

    2007-05-01

    syndromes , such as urinary incontinence. Each of these areas of assessment is briefly discussed. Table 3 Approaches for medical assessment within the...Final PREPARED FOR: U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012...SPONSOR/MONITOR’S ACRONYM(S) U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 11. SPONSOR/MONITOR’S REPORT

  9. Sequencing: Targeting Insurgents and Drugs in Colombia

    DTIC Science & Technology

    2007-03-01

    process . In Colombia, proponents for a purely counter-insurgency strategy state Colombia’s violence existed decades before the drug industry...8 Both the AUC and the ELN will only be mentioned briefly as the demobilization process with the paramilitaries and the...that extracted revenues at every phase of the illicit drug process —from the transportation of precursor chemical to the transportation of the final

  10. Construction of a Penrose Diagram for a Spatially Coherent Evaporating Black Hole

    NASA Technical Reports Server (NTRS)

    Brown, Beth A.; Lindesay, James

    2007-01-01

    A Penrose diagram is constructed for an example black hole that evaporates at a steady rate as measured by a distant observer, until the mass vanishes, yielding a final state Minkowski space-time. Coordinate dependencies of significant features, such as the horizon and coordinate anomalies, are clearly demonstrated on the diagram. The large-scale causal structure of the space-time is briefly discussed.

  11. Suppression of BRCA2 by Mutant Mitochondrial DNA in Prostate Cancer

    DTIC Science & Technology

    2011-05-01

    Briefly, the electron transfer activities of complex I/III (NADH dehydrogenase/cytochrome bc1 complex: catalyzes the electron transfer from NADH to...ferricytochrome c) and complex II/III (succinate dehydrogenase/cytochrome bc1 complex: catalyzes the electron transfer from succinate to ferricytochrome...The electron transfer activity of complex IV (cytochrome c oxidase: catalyzes the final step of the respiratory chain by transferring electrons from

  12. F-14 modeling study

    NASA Technical Reports Server (NTRS)

    Levison, W. H.; Baron, S.

    1984-01-01

    Preliminary results in the application of a closed loop pilot/simulator model to the analysis of some simulator fidelity issues are discussed in the context of an air to air target tracking task. The closed loop model is described briefly. Then, problem simplifications that are employed to reduce computational costs are discussed. Finally, model results showing sensitivity of performance to various assumptions concerning the simulator and/or the pilot are presented.

  13. Modelling regulation of decomposition and related root/mycorrhizal processes in arctic tundra soils

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Linkins, A.E.

    1992-01-01

    Since this was the final year of this project principal activities were directed towards either collecting data needed to complete existing incomplete data sets or writing manuscripts. Data sets on Imnaviat Creek watershed basin are functionally complete and data finialized on the cellulose mineralizaiton and dust impact on soil organic carbon and phsophorus decomposition. Seven manuscripts were prepared, and are briefly outlined.

  14. Multi-Core Processors: An Enabling Technology for Embedded Distributed Model-Based Control (Postprint)

    DTIC Science & Technology

    2008-07-01

    generation of process partitioning, a thread pipelining becomes possible. In this paper we briefly summarize the requirements and trends for FADEC based... FADEC environment, presenting a hypothetical realization of an example application. Finally we discuss the application of Time-Triggered...based control applications of the future. 15. SUBJECT TERMS Gas turbine, FADEC , Multi-core processing technology, disturbed based control

  15. Windshear detection radar signal processing studies

    NASA Technical Reports Server (NTRS)

    Baxa, Ernest G., Jr.

    1993-01-01

    This final report briefly summarizes research work at Clemson in the Radar Systems Laboratory under the NASA Langley Research Grant NAG-1-928 in support of the Antenna and Microwave Branch, Guidance and Control Division, program to develop airborne sensor technology for the detection of low altitude windshear. A bibliography of all publications generated by Clemson personnel is included. An appendix provides abstracts of all publications.

  16. Battery development and testing at ESA

    NASA Technical Reports Server (NTRS)

    Verniolle, Jean

    1987-01-01

    The principal activities of the Energy Storage Section of the Space Research and Technology Center (ESTEC) of the European Space Agency are presented. Nickel-hydrogen and fuel cell systems development are reported. The European Space Battery Test Center (ESBTC) facilities are briefly described along with the current test programs and results obtained.

  17. Celebrating a Century of Flight

    NASA Technical Reports Server (NTRS)

    2002-01-01

    The history of aviation is briefly covered in this publication, with sections on the Wright brothers, the balloons of the Montgolfier brothers, other early aviation pioneers before the Wright brothers, the role of aircraft in the world wars, air mail, Charles Lindbergh, women aviators, the jet age, and the space age, among other topics.

  18. Computerized Television: New Developments in Television Production Techniques.

    ERIC Educational Resources Information Center

    Metallinos, Nikos

    Based on the notion that technological and artistic developments in the area of television production affect viewers' comprehension and appreciation of televised programs, this essay examines the impact of telecommunication advances on the industry. The first section briefly considers the technological advances of the last decade in major TV…

  19. Theoretical Bases for Teacher- and Peer-Delivered Sexual Health Promotion

    ERIC Educational Resources Information Center

    Wight, Daniel

    2008-01-01

    Purpose: This paper seeks to explore the theoretical bases for teacher-delivered and peer-delivered sexual health promotion and education. Design/methodology/approach: The first section briefly outlines the main theories informing sexual health interventions for young people, and the second discusses their implications for modes of delivery.…

  20. The Laws Are Yours.

    ERIC Educational Resources Information Center

    Lawyers' Wives of Wisconsin, Racine.

    The pamphlet briefly describes various facets of the law and legal system in Wisconsin, and defines many legal terms. The objective is to further public understanding of the law and of the legal profession, particularly in Wisconsin. No attempt is made to answer specific legal questions. Sections cover civil and criminal law; the federal court…

  1. Freedom of Conscience and Catholic Schools

    ERIC Educational Resources Information Center

    Donlevy, J. K.; Gereluk, D.; Patterson, P.; Brandon, J.

    2014-01-01

    This paper's purpose is to extensively review the historical understanding of conscience and the current juridical interpretation of freedom of conscience under section 2(a) of the Canadian Charter of Rights and Freedoms (1982). It then briefly notes that given the challenge faced by Ontario's Catholic schools in providing for inclusionary…

  2. Argumentation and the Unconscious.

    ERIC Educational Resources Information Center

    Hample, Dale

    Noting that--although explicit attention to the unconscious has been rare in argument theories--the notion is unavoidable in any full theory, this paper argues that the unconscious plays a central role in argumentation. After briefly discussing the characteristics of the unconscious, the first section of the paper presents an analysis of…

  3. Depression: What We Know.

    ERIC Educational Resources Information Center

    Lobel, Brana; Hirschfeld, Robert M. A.

    This booklet is concerned with the area of clinical depression. Questions about clinical depression are briefly answered in an overview section and are examined in greater detail in the five chapters that follow. In chapter 1, depression is defined and various types of depression are identified. The origins of depression are explored in the second…

  4. Multiple Literacies, Curriculum, and Instruction in Early Childhood and Elementary School

    ERIC Educational Resources Information Center

    Larson, Joanne

    2006-01-01

    This article describes some implications of using a multiple literacies perspective in the construction and implementation of literacy curriculum, pedagogy, and assessment in early childhood and elementary classrooms. After briefly laying out a theoretical perspective in sections focusing on early literacy, academic learning, literacy beyond…

  5. 32 CFR 651.21 - Finding of no significant impact.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Finding of no significant impact. 651.21 Section... of no significant impact. A Finding of No Significant Impact (FNSI) is a document that briefly states... comments, the proponent forwards a decision package that includes a comparison of environmental impacts...

  6. Learning behind Bars: Selected Educational Programs from Juvenile, Jail and Prison Facilities.

    ERIC Educational Resources Information Center

    Sawyer, Richard; Cosgrove, Susan, Ed.

    This report describes briefly a number of highly effective educational programs in correctional settings. The programs are divided into three sections: juvenile correctional education, local detention/community correctional education, and prison education. Information provided for each program includes address and telephone number; type of…

  7. Tutoring ESL: A Handbook for Volunteers.

    ERIC Educational Resources Information Center

    Reck, Deborah L.; And Others

    This handbook is designed for use by Tacoma Community House volunteer tutors of English as a Second Language (ESL) as a supplement to basic volunteer training. The handbook includes detailed information in areas briefly covered during training and specific instructional ideas and class activities. A section on getting started discusses the…

  8. Family Life Education in Multicultural Classrooms. Practical Guidelines.

    ERIC Educational Resources Information Center

    Abbey, Nancy; And Others

    This guide presents approaches and guidelines for developing culturally appropriate and relevant family life education. It begins with a definition of culture and a look at different types of acculturation. A section on cultural relevance in family life education briefly explains the challenge of a multicultural approach in family life education…

  9. 10 CFR 205.193 - Notice of Objection.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Appeals. The Notice shall be filed in duplicate, shall briefly describe how the person would be aggrieved... 10 Energy 3 2010-01-01 2010-01-01 false Notice of Objection. 205.193 Section 205.193 Energy DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS Notice of Probable Violation, Remedial Order...

  10. 10 CFR 205.193 - Notice of Objection.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Appeals. The Notice shall be filed in duplicate, shall briefly describe how the person would be aggrieved... 10 Energy 3 2011-01-01 2011-01-01 false Notice of Objection. 205.193 Section 205.193 Energy DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS Notice of Probable Violation, Remedial Order...

  11. Publishing: Alternatives and Economics.

    ERIC Educational Resources Information Center

    Penchansky, Mimi; And Others

    The Library Association of the City University of New York presents an annotated bibliography on the subject of small and alternative publishing. In the first section directories, indexes, catalogs, and reviews are briefly described. Book distributors for small publishers are listed next. The major portion of the bibliography is a listing of books…

  12. A Bibliography of Philippine Language Dictionaries and Vocabularies. Special Monograph Issue, Number 30.

    ERIC Educational Resources Information Center

    Hendrickson, Gail R., Comp.; Newell, Leonard E., Comp.

    This bibliography is a comprehensive listing of dictionaries and vocabularies, published and unpublished, of the Philippine languages. Introductory sections chronicle briefly the histories of Philippine lexicography and Philippine bibliographies, describe the scope of the present work, and outline the organization of the bibliography itself and…

  13. 40 CFR 1508.13 - Finding of no significant impact.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ....13 Section 1508.13 Protection of Environment COUNCIL ON ENVIRONMENTAL QUALITY TERMINOLOGY AND INDEX § 1508.13 Finding of no significant impact. Finding of no significant impact means a document by a Federal agency briefly presenting the reasons why an action, not otherwise excluded (§ 1508.4), will not...

  14. Eventos de Diciembre (December Events).

    ERIC Educational Resources Information Center

    Pla, Myrna; Toro, Leonor

    Written in Spanish, this booklet contains information on three events occurring in the month of December: winter, Christmas, and New Year's Eve. Winter is briefly discussed. The section on Christmas includes a short story ("La Nochebuena"); a poem about Christmas in Puerto Rico; a legend about the poinsettia; brief discussion of Santa…

  15. Handicapped Children's Early Education Program. 1982-83 Overview and Directory.

    ERIC Educational Resources Information Center

    Assael, Daniel, Ed.

    The document serves as a directory of federal projects in the Handicapped Children's Early Education Program (HCEEP). An introduction describes the HCEEP network and briefly summarizes results of a recent evaluation study. The overview section then describes the five types of HCEEP projects: deomonstration projects, outreach projects, state…

  16. Electron scattering by molecules. II - Experimental methods and data

    NASA Technical Reports Server (NTRS)

    Trajmar, S.; Chutjian, A.; Register, D. F.

    1983-01-01

    Experimental techniques for measuring electron-molecule collision cross sections are briefly summarized. A survey of the available experimental cross section data is presented. The emphasis here is on elastic scattering, rotational, vibrational and electronic excitations, total electron scattering, and momentum transfer in the few eV to few hundred eV impact energy range. Reference is made to works concerned with high energy electron scattering, innershell and multi-electron excitations, conicidence methods and electron scattering in laser fields.

  17. Crystallization processes in pharmaceutical technology and drug delivery design

    NASA Astrophysics Data System (ADS)

    Shekunov, B. Yu; York, P.

    2000-04-01

    Crystallization is a major technological process for particle formation in pharmaceutical industry and, in addition, plays an important role in defining the stability and drug release properties of the final dosage forms. Industrial and regulatory aspects of crystallization are briefly reviewed with reference to solid-state properties of pharmaceuticals. Crystallization, incorporating wider definition to include precipitation and solid-state transitions, is considered in terms of preparation of materials for direct compression, formation of amorphous, solvated and polymorphic forms, chiral separation of drugs, production of materials for inhalation drug delivery and injections. Finally, recent developments in supercritical fluid particle technology is considered in relationship to the areas discussed.

  18. [Helminth migration in the host].

    PubMed

    Horák, Petr

    2006-08-01

    Helminths belong to important human pathogens in tropical and subtropical countries. They have simple one-host life cycles or they use several hosts for their development. There are two main entry points for human helminths: the skin and the oral cavity. Skin penetration is followed by tissue migration of helminth stages towards target organs. Also some perorally acquired helminths migrate throughout the human body and then (a) they return to and mature in the intestine or (b) they search for specific final location in other (extraintestinal) tissues/organs. Particular developmental stages having different migration routes, and different roles of human beings as final, intermediate and paratenic hosts are briefly mentioned.

  19. Computer technology applications in industrial and organizational psychology.

    PubMed

    Crespin, Timothy R; Austin, James T

    2002-08-01

    This article reviews computer applications developed and utilized by industrial-organizational (I-O) psychologists, both in practice and in research. A primary emphasis is on applications developed for Internet usage, because this "network of networks" changes the way I-O psychologists work. The review focuses on traditional and emerging topics in I-O psychology. The first topic involves information technology applications in measurement, defined broadly across levels of analysis (persons, groups, organizations) and domains (abilities, personality, attitudes). Discussion then focuses on individual learning at work, both in formal training and in coping with continual automation of work. A section on job analysis follows, illustrating the role of computers and the Internet in studying jobs. Shifting focus to the group level of analysis, we briefly review how information technology is being used to understand and support cooperative work. Finally, special emphasis is given to the emerging "third discipline" in I-O psychology research-computational modeling of behavioral events in organizations. Throughout this review, themes of innovation and dissemination underlie a continuum between research and practice. The review concludes by setting a framework for I-O psychology in a computerized and networked world.

  20. Hydrogeochemical and stream sediment reconnaissance basic data report for Kingman NTMS Quadrangle, Arizona, California, and Nevada

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Qualheim, B.J.

    This report presents the results of the geochemical reconnaissance sampling in the Kingman 1 x 2 quadrangle of the National Topographical Map Series (NTMS). Wet and dry sediment samples were collected throughout the 18,770-km arid to semiarid area and water samples at available streams, springs, and wells. Neutron activation analysis of uranium and trace elements and other measurements made in the field and laboratory are presented in tabular hardcopy and microfiche format. The report includes five full-size overlays for use with the Kingman NTMS 1 : 250,000 quadrangle. Water sampling sites, water sample uranium concentrations, water-sample conductivity, sediment sampling sites,more » and sediment-sample total uranium and thorium concentrations are shown on the separate overlays. General geological and structural descriptions of the area are included and known uranium occurrences on this quadrangle are delineated. Results of the reconnaissance are briefly discussed and related to rock types in the final section of the report. The results are suggestive of uranium mineralization in only two areas: the Cerbat Mountains and near some of the western intrusives.« less

  1. Alcohol Versus Cannabinoids: A Review of Their Opposite Neuro-Immunomodulatory Effects and Future Therapeutic Potentials

    PubMed Central

    Nair, Madhavan P.; Figueroa, Gloria; Casteleiro, Gianna; Muñoz, Karla; Agudelo, Marisela

    2015-01-01

    Due to the legalization of marijuana and the increased demand for cannabis and alcohol consumption, research efforts highlighting the biomedical consequences of the use of alcohol and cannabinoids are not only relevant to the substance abuse scientific field, but are also of public health interest. Moreover, an overview of the recent literature about alcohol and cannabinoids neuro-immunomodulatory effects highlighting their future therapeutic potentials will provide a significant contribution to science and medicine. Therefore, in the current review, we will first discuss briefly the prevalence of alcohol and marijuana abuse, followed by a discussion on the individual effects of alcohol and cannabinoids on the immune system; then, we will focus on the role of endocannabinoids on the alcohol-induced inflammatory effects. In addition, the review also incorporates cytokine array data obtained from human monocyte-derived dendritic cells, providing a different perspective on the alcohol and cannabinoid abuse divergent effects on cytokine production. The final section will highlight the therapeutic potential of cannabinoid receptors and the novel strategies to treat alcohol dependence as determined by in vitro, in vivo and clinical studies. PMID:26478902

  2. Terminology for contrast-enhanced sonography: a practical glossary.

    PubMed

    Catalano, Orlando; Migaleddu, Vincenzo; Quaia, Emilio; Caruso, Giuseppe

    2007-06-01

    The purpose of this glossary is to offer an updated guide to the correct terminology for contrast-enhanced sonography. This report was prepared by a panel of radiologists from the Sonography Section of the Italian Association of Medical Radiology. A leading author prepared a list of terms based on a comprehensive literature survey. The draft was analyzed by 3 experts on the topic of contrast-enhanced sonography. These reviewers reached a consensus and prepared the final version. A list of 137 terms is included. These terms are briefly defined. Their proper application is discussed, with special reference to potential misleading uses. Contrast-enhanced sonography is a relatively new diagnostic tool, now entering clinical practice in several countries. Use of appropriate, universal terminology is mandatory in the scientific setting to allow comparison between different published experiences. Additionally, use of clear, standardized terminology is necessary in the clinical setting to facilitate report understanding by the referring physician. Standardized, nonequivocal nomenclature may also help future diffusion of sonographic contrast media in countries where their application is still not approved.

  3. Integrability of the Ad{{S}_{5}}\\times {{S}^{5}} superstring and its deformations

    NASA Astrophysics Data System (ADS)

    van Tongeren, Stijn J.

    2014-10-01

    This article reviews the application of integrability to the spectral problem of strings on Ad{{S}5}× {{S}5} and its deformations. We begin with a pedagogical introduction to integrable field theories culminating in the description of their finite-volume spectra through the thermodynamic Bethe ansatz (TBA). Next, we apply these ideas to the Ad{{S}5}× {{S}5} string and in later sections discuss how to account for particular integrable deformations. Through the AdS/CFT correspondence this gives an exact description of anomalous scaling dimensions of single trace operators in planar N=4 supersymmetry Yang-Mills theory, its ‘orbifolds’, and β and γ-deformed supersymmetric Yang-Mills theory. We also touch upon some subtleties arising in these deformed theories. Furthermore, we consider complex excited states (bound states) in the su(2) sector and give their TBA description. Finally we discuss the TBA for a quantum deformation of the Ad{{S}5}× {{S}5} superstring S-matrix, with close relations to among others Pohlmeyer reduced string theory, and briefly indicate more recent developments in this area.

  4. Simulation Models of Obesity: A Review of the Literature and Implications for Research and Policy

    PubMed Central

    Levy, David T.; Mabry, Patricia L.; Wang, Y. Claire; Gortmaker, Steve; Huang, Terry T-K; Marsh, Tim; Moodie, Marj; Swinburn, Boyd

    2015-01-01

    Simulation models (SMs) combine information from a variety of sources to provide a useful tool for examining how the effects of obesity unfold over time and impact population health. SMs can aid in the understanding of the complex interaction of the drivers of diet and activity and their relation to health outcomes. As emphasized in a recently released report of the Institute or Medicine, SMs can be especially useful for considering the potential impact of an array of policies that will be required to tackle the obesity problem. The purpose of this paper is to present an overview of existing SMs for obesity. First, a background section introduces the different types of models, explains how models are constructed, shows the utility of SMs, and discusses their strengths and weaknesses. Using these typologies, we then briefly review extant obesity SMs. We categorize these models according to their focus: health and economic outcomes, trends in obesity as a function of past trends, physiologically-based behavioral models, environmental contributors to obesity, and policy interventions. Finally, we suggest directions for future research. PMID:20973910

  5. Integrity management of offshore structures and its implication on computation of structural action effects and resistance

    NASA Astrophysics Data System (ADS)

    Moan, T.

    2017-12-01

    An overview of integrity management of offshore structures, with emphasis on the oil and gas energy sector, is given. Based on relevant accident experiences and means to control the associated risks, accidents are categorized from a technical-physical as well as human and organizational point of view. Structural risk relates to extreme actions as well as structural degradation. Risk mitigation measures, including adequate design criteria, inspection, repair and maintenance as well as quality assurance and control of engineering processes, are briefly outlined. The current status of risk and reliability methodology to aid decisions in the integrity management is briefly reviewed. Finally, the need to balance the uncertainties in data, methods and computational efforts and the cautious use and quality assurance and control in applying high fidelity methods to avoid human errors, is emphasized, and with a plea to develop both high fidelity as well as efficient, simplified methods for design.

  6. A digital future for the history of psychology?

    PubMed

    Green, Christopher D

    2016-08-01

    This article discusses the role that digital approaches to the history of psychology are likely to play in the near future. A tentative hierarchy of digital methods is proposed. A few examples are briefly described: a digital repository, a simple visualization using ready-made online database and tools, and more complex visualizations requiring the assembly of the database and, possibly, the analytic tools by the researcher. The relationship of digital history to the old "New Economic History" (Cliometrics) is considered. The question of whether digital history and traditional history need be at odds or, instead, might complement each other is woven throughout. The rapidly expanding territory of digital humanistic research outside of psychology is briefly discussed. Finally, the challenging current employment trends in history and the humanities more broadly are considered, along with the role that digital skills might play in mitigating those factors for prospective academic workers. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  7. The Vaccination Model in Psychoneuroimmunology Research: A Review.

    PubMed

    Whittaker, Anna C

    2018-01-01

    This chapter explores the reasoning behind using the vaccination model to examine the influence of psychosocial factors on immunity. It then briefly discusses the mechanics of the vaccination response and the protocols used in psychoneuroimmunology vaccine research, before giving examples from the research literature of the studies examining relationships such as the association between stress and vaccination response. It also explores the ways the vaccination model can be used to answer key questions in psychoneuroimmunology, such as the following: "Does it matter when stressful life events occur relative to when the vaccine is received?" "What are the effects of prior exposure to the antigen?" "Do other psychosocial factors influence vaccine response besides stress?" Finally, it briefly considers the mechanisms underlying psychosocial factors and vaccination response associations and the future research needed to understand these better, and indeed to use current and future knowledge to improve and enhance vaccine responses in key at-risk populations.

  8. The Service System's Hidden Places: Adult Homes and Room and Board Homes Housing People with Developmental Disability and Psychiatric Labels in Onondaga County. Final Edition.

    ERIC Educational Resources Information Center

    Racino, Julie Ann; And Others

    The paper describes adult homes and room and board homes serving persons with disabilities in Onondaga County, New York. Visits were made to eight adult homes and five room and board homes. Briefly considered are ownership and licensing regulations, referrals, and admission criteria. Observations at the homes are offered. Concerns are raised about…

  9. Petrologic insights into basaltic volcanism at historically active Hawaiian volcanoes: Chapter 6 in Characteristics of Hawaiian volcanoes

    USGS Publications Warehouse

    Helz, Rosalind L.; Clague, David A.; Sisson, Thomas W.; Thornber, Carl R.; Poland, Michael P.; Takahashi, T. Jane; Landowski, Claire M.

    2014-01-01

    Contributions to our knowledge of the nature of the mantle source(s) of Hawaiian basalts are reviewed briefly, although this is a topic where debate is ongoing. Finally, our accumulated petrologic observations impose constraints on the nature of the summit reservoirs at Kīlauea and Mauna Loa, specifically whether the summit chamber has been continuous or segmented during past decades.

  10. Present knowledge of immunization against tuberculosis

    PubMed Central

    ten Dam, H. G.; Toman, K.; Hitze, K. L.; Guld, J.

    1976-01-01

    This is a selective review, which, after recalling some immunological aspects, analyses the present knowledge on the protective efficacy of BCG vaccination, the vaccination reactions and complications that may be observed, and current methods of vaccine production and control. As regards the application of BCG vaccination, particular attention is given to dosage and vaccination techniques, direct and simultaneous vaccination, and revaccination. Finally, the evaluation of BCG vaccination programmes is briefly discussed. PMID:798638

  11. Balancing Human Rights and Civil Liberties in an Emerging Democracy: Education Law, Policy and Practice in South Africa.

    ERIC Educational Resources Information Center

    Beckmann, Johan; Maile, Simeon; van Vollenhoven, Willie; Joubert Rika

    This outline is part of a collection of 54 papers from the 48th annual conference of the Education Law Association held in November 2002. It covers a presentation on changes in the law and social structure of South Africa. As an outline, it briefly touches upon a number of topics, but focuses mainly on South Africa's emerging "final"…

  12. A perspective on unstructured grid flow solvers

    NASA Technical Reports Server (NTRS)

    Venkatakrishnan, V.

    1995-01-01

    This survey paper assesses the status of compressible Euler and Navier-Stokes solvers on unstructured grids. Different spatial and temporal discretization options for steady and unsteady flows are discussed. The integration of these components into an overall framework to solve practical problems is addressed. Issues such as grid adaptation, higher order methods, hybrid discretizations and parallel computing are briefly discussed. Finally, some outstanding issues and future research directions are presented.

  13. Multi-threading: A new dimension to massively parallel scientific computation

    NASA Astrophysics Data System (ADS)

    Nielsen, Ida M. B.; Janssen, Curtis L.

    2000-06-01

    Multi-threading is becoming widely available for Unix-like operating systems, and the application of multi-threading opens new ways for performing parallel computations with greater efficiency. We here briefly discuss the principles of multi-threading and illustrate the application of multi-threading for a massively parallel direct four-index transformation of electron repulsion integrals. Finally, other potential applications of multi-threading in scientific computing are outlined.

  14. A Guide to the Recorded Distribution of Endangered, Threatened and Rare Species in Michigan. Providing a Bibliographic Discussion of the Subject, Annotated List of Reference Sources and Directory of Local Nature Associations, Centers, Agencies, and University Field Stations.

    ERIC Educational Resources Information Center

    Yakes, Nancy A.

    This document is a guide to sources of information on endangered species distribution in Michigan. It was prepared for CETA (Comprehensive Employment and Training Act) students who will collect the documents. The guide is divided into three major sections. The first section includes an introduction (briefly discussing endangered, rare, threatened…

  15. “The Good, the Bad and the Ugly” of Chitosans

    PubMed Central

    Bellich, Barbara; D’Agostino, Ilenia; Semeraro, Sabrina; Gamini, Amelia; Cesàro, Attilio

    2016-01-01

    The objective of this paper is to emphasize the fact that while consistent interest has been paid to the industrial use of chitosan, minor attention has been devoted to spread the knowledge of a good characterization of its physico-chemical properties. Therefore, the paper attempts to critically comment on the conflicting experimental results, highlighting the facts, the myths and the controversies. The goal is to indicate how to take advantage of chitosan versatility, to learn how to manage its variability and show how to properly tackle some unexpected undesirable features. In the sections of the paper various issues that relate chitosan properties to some basic features and to advanced solutions and applications are presented. The introduction outlines some historical pioneering works, where the chemistry of chitosan was originally explored. Thereafter, particular reference is made to analytical purity, characterization and chain modifications. The macromolecular characterization is mostly related to molecular weight and to degree of acetylation, but also refers to the conformational and rheological properties and solution stability. Then, the antimicrobial activity of chitosan in relation with its solubility is reviewed. A section is dedicated to the formulation of chitosan biomaterials, from gel to nanobeads, exploring their innovative application as active carrier nanoparticles. Finally, the toxicity issue of chitosan as a polymer and as a constructed nanomaterial is briefly commented in the conclusions. PMID:27196916

  16. The principle of proportionality revisited: interpretations and applications.

    PubMed

    Hermerén, Göran

    2012-11-01

    The principle of proportionality is used in many different contexts. Some of these uses and contexts are first briefly indicated. This paper focusses on the use of this principle as a moral principle. I argue that under certain conditions the principle of proportionality is helpful as a guide in decision-making. But it needs to be clarified and to be used with some flexibility as a context-dependent principle. Several interpretations of the principle are distinguished, using three conditions as a starting point: importance of objective, relevance of means, and most favourable option. The principle is then tested against an example, which suggests that a fourth condition, focusing on non-excessiveness, needs to be added. I will distinguish between three main interpretations of the principle, some primarily with uses in research ethics, others with uses in other areas of bioethics, for instance in comparisons of therapeutic means and ends. The relations between the principle of proportionality and the precautionary principle are explored in the following section. It is concluded that the principles are different and may even clash. In the next section the principle of proportionality is applied to some medical examples drawn from research ethics and bioethics. In concluding, the status of the principle of proportionality as a moral principle is discussed. What has been achieved so far and what remains to be done is finally summarized.

  17. Evaluating Text-Based Information on the World Wide Web

    ERIC Educational Resources Information Center

    Wopereis, Iwan G. J. H.; van Merrienboer, Jeroen J. G.

    2011-01-01

    This special section contributes to an inclusive cognitive model of information problem solving (IPS) activity, touches briefly IPS learning, and brings to the notice methodological pitfalls related to uncovering IPS processes. Instead of focusing on the IPS process as a whole, the contributing articles turn their attention to what is regarded the…

  18. Technological Collaborations: K-12 and Higher Education. Fastback 438.

    ERIC Educational Resources Information Center

    Ferguson, Kay McPherson; Kopp, O. W.

    This brief report examines various ways in which K-12 schools and institutions of higher education can collaborate to effect critical changes in teaching and learning through the use of computers. The first section briefly reviews the history of computer use in education, noting such critical needs as teacher training, and reviews the…

  19. Cinemabilia; Catalogue of Film Literature.

    ERIC Educational Resources Information Center

    Cinemabilia, New York, NY.

    The catalog lists and briefly annotates more than 3,500 current, second-hand, and out-of-print books about film that are available from Cinemabilia, New York City. The catalog is divided into 37 categories. The section on special genre lists works on horror, science fiction, Westerns, and Tarzan films, ranging from "Drums of Fu-Manchu" to "Movie…

  20. Map and Compass. Outdoor Living Skills Series. Instructor Manual.

    ERIC Educational Resources Information Center

    Ludwig, Gail S.

    Designed for instructors with little or no map and compass experience, the self-contained manual contains background information, lesson plans, student handouts, and references for teaching the basic skills of map and compass use to junior high and senior high school students and youth groups. An introductory section briefly discusses the…

  1. Breaking the Cost Barrier in Automatic Classification.

    ERIC Educational Resources Information Center

    Doyle, L. B.

    A low-cost automatic classification method is reported that uses computer time in proportion to NlogN, where N is the number of information items and the base is a parameter, some barriers besides cost are treated briefly in the opening section, including types of intellectual resistance to the idea of doing classification by content-word…

  2. Establishment of design criteria for acceptable failure modes and fail safe considerations for the space shuttle structural system

    NASA Technical Reports Server (NTRS)

    Westrup, R. W.

    1971-01-01

    The application of general design approaches for preventing failures due to repeated load cycles is briefly discussed. Program objective, mission requirements, and structural design criteria are summarized. Discrete structural elements and associated sections were selected for detailed strength, fatigue, and fracture mechanics investigations.

  3. Center for Research for Mothers and Children. 1988 Progress Report.

    ERIC Educational Resources Information Center

    National Inst. of Child Health and Human Development (NIH), Bethesda, MD. Center for Research for Mothers and Children.

    The 1988 Progress Report covers research activities of the five branches of the Center for Research for Mothers and Children of the National Institute of Child Health and Human Development. An introductory section briefly describes the Center, notes staff activities and Center sponsored conferences and workshops, and identifies highlights of…

  4. The Technology Implications of "A Nation at Risk"

    ERIC Educational Resources Information Center

    Allen, Lee

    2008-01-01

    In 1983, when "A Nation at Risk" appeared, it offered recommendations in the areas of content, standards and expectations, time, teaching, and leadership and fiscal support. The growing use of technology was addressed briefly in the section dealing with "indicators of risk," which listed examples of deficiencies in education as compared to the…

  5. The Americans with Disabilities Act (ADA) Employment Handbook.

    ERIC Educational Resources Information Center

    Alaska State Americans with Disabilities Act Compliance Office, Juneau.

    This handbooks is intended to provide Alaska state agencies and other employers in Alaska with a reference guide to assist in meeting the employment provisions of the Americans with Disabilities Act (ADA) of 1990. The first section briefly reports on a national survey to measure business awareness, attitudes, and reactions to the Act. Summarized…

  6. 22 CFR 1422.10 - Motions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... them, except that a motion to dismiss a petition shall be referred for appropriate action at such time... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Motions. 1422.10 Section 1422.10 Foreign... § 1422.10 Motions. (a) General. (1) A motion shall state briefly the order or relief sought and the...

  7. 22 CFR 1422.10 - Motions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... them, except that a motion to dismiss a petition shall be referred for appropriate action at such time... 22 Foreign Relations 2 2011-04-01 2009-04-01 true Motions. 1422.10 Section 1422.10 Foreign... § 1422.10 Motions. (a) General. (1) A motion shall state briefly the order or relief sought and the...

  8. Micro-Scale Flapping Wings for the Advancement of Flying MEMS

    DTIC Science & Technology

    2009-03-01

    section. As air strikes the airfoil, it is divided over and under the wing. The airfoil is curved in a manner such that the air passing over the wing moves...This table briefly describes the L-edit layout of Figure A.1. MUMPS Run 82 Micromirrors Mirrors fabricated to EENG 636 specifications Thermal

  9. Black-sphere approximation to nuclei and its application to reactions with neutron-rich nuclei

    NASA Astrophysics Data System (ADS)

    Kohama, Akihisa; Iida, Kei; Oyamatsu, Kazuhiro

    2013-09-01

    We briefly review our formula for a proton-nucleus total reaction cross section, σR, constructed in the black-sphere approximation of nuclei, in which a nucleus is viewed as a "black" sphere of radius "a". An extension to reactions involving neutron-rich nuclei is also reported.

  10. 29 CFR 16.201 - Contents of application.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... describe briefly the type and purpose of its organization or business. (b) The application shall also... cooperative association as defined in section 15(a) of the Agricultural Marketing Act (12 U.S.C. 1141j(a)). (c... unincorporated business, the application shall certify that it did not have more than 500 employees at the time...

  11. Mucking in and Mucking out: Vocational Learning in Animal Care

    ERIC Educational Resources Information Center

    Salisbury, Jane; Jephcote, Martin

    2010-01-01

    The paper draws upon empirical material from a two year qualitative research project. The paper briefly outlines the key research questions, research design and data collection strategies. The following sections draw on observational, interview and journal data from the learning sites and the teachers and students who work and learn in them are…

  12. Building Trust among Educational Stakeholders through Participatory School Administration, Leadership and Management

    ERIC Educational Resources Information Center

    San Antonio, Diosdado M.; Gamage, David T.

    2007-01-01

    This paper examines the impact of implementing Participatory School Administration, Leadership and Management (PSALM) on the levels of trust among the educational stakeholders in Philippine public secondary schools. After an introductory section, the research context is provided by briefly reviewing relevant literature on PSALM and on trust and by…

  13. Coping with AIDS: Psychological and Social Considerations in Helping People with HTLV-III Infection.

    ERIC Educational Resources Information Center

    Runck, Bette

    This booklet was written to familiarize health and mental health professionals and paraprofessionals with the psychological and social problems associated with acquired immune deficiency syndrome (AIDS). It briefly reviews the realities of AIDS and describes the challenge that AIDS poses for health care professionals. A section on neuropsychiatric…

  14. The Mexican-American and the United States.

    ERIC Educational Resources Information Center

    Bustamante, Charles J.; Bustamante, Patricia L.

    The historical study of the plight of Mexican Americans is divided into 3 sections. Part I relates the beginnings of Mexico, from Spanish injustices to the Indians to how the Indians felt about Black men. Various historical facts are briefly presented. Part II treats Mexico's efforts to become a republic, various aspects of the wars between…

  15. Self Confrontation Counseling: A Selective Review With Implications for Teacher Education.

    ERIC Educational Resources Information Center

    Fuller, Frances F.; And Others

    This report reviews relevant educational literature and current practices to discover the relationship between personal change and self confrontation. Five areas of study include a) outcomes, b) help for whom, c) the helpful situation, d) the helpful treatment, and e) the helpful helper. The first section briefly describes the outcomes of self…

  16. Major clinical research advances in gynecologic cancer in 2013.

    PubMed

    Suh, Dong Hoon; Kim, Jae-Weon; Kang, Sokbom; Kim, Hak Jae; Lee, Kyung-Hun

    2014-07-01

    In 2013, 10 topics were selected for major clinical research advances in gynecologic oncology; these included three topics regarding cervical cancer, three regarding ovarian cancer, two regarding endometrial cancer, and one each regarding breast cancer and radiation oncology. For cervical cancer, bevacizumab was first demonstrated to exhibit outstanding clinical efficacy in a recurrent, metastatic setting. Regarding cervical cancer screening, visual inspections with acetic acid in low-resource settings, p16/Ki-67 double staining, and the follow-up results of four randomized controlled trials of human papillomavirus-based screening methods were reviewed. Laparoscopic para-aortic lymphadenectomy before chemoradiation for locally advanced cervical cancer was the final topic for cervical cancer. Regarding front-line ovarian cancer therapies, dose-dense paclitaxel and carboplatin, intraperitoneal chemotherapy, and other targeted agents administered according to combination or maintenance schedules were discussed. Regarding recurrent ovarian cancer treatment, cediranib, olaparib, and farletuzumab were discussed for platinum-sensitive disease. The final overall survival data associated with a combination of bevacizumab and chemotherapy for platinum-resistant disease were briefly summarized. For endometrial cancer, the potential clinical efficacy of metformin, an antidiabetic drug, in obese patients was followed by integrated genomic analyses from the Cancer Genome Atlas Research Network. For breast cancer, three remarkable advances were reviewed: the long-term effects of continued adjuvant tamoxifen for 10 years, the effects of 2-year versus 1-year adjuvant trastuzumab for human epidermal growth factor receptor 2-positive disease, and the approval of pertuzumab in a neoadjuvant setting with a pathologic complete response as the surrogate endpoint. Finally, the recent large studies of intensity-modulated radiotherapy for gynecologic cancer were briefly summarized.

  17. Design and performance of controlled-diffusion stator compared with original double-circular-arc stator

    NASA Technical Reports Server (NTRS)

    Gelder, Thomas F.; Schmidt, James F.; Suder, Kenneth L.; Hathaway, Michael D.

    1987-01-01

    The capabilities of two stators, one with controlled-diffusion (CD) blade sections and one with double-circular-arc (DCA) blade sections, were compared. A CD stator was designed and tested that had the same chord length but half the blades of the DCA stator. The same fan rotor (tip speed, 429 m/sec; pressure ratio, 1.65) was used with each stator row. The design and analysis system is briefly described. The overall stage and rotor performances with each stator are compared, as are selected blade element data. The minimum overall efficiency decrement across the stator was approximately 1 percentage point greater with the CD balde sections than with the DCA blade sections.

  18. Design and performance of controlled-diffusion stator compared with original double-circular-arc stator

    NASA Technical Reports Server (NTRS)

    Gelder, Thomas F.; Schmidt, James F.; Suder, Kenneth L.; Hathaway, Michael D.

    1987-01-01

    The capabilities of two stators, one with controlled-diffusion (CD) blade sections and one with double-circular-arc (DCA) blade sections, were compared. A CD stator was designed and tested that had the same chord length but half the blades of the DCA stator. The same fan rotor (tip speed, 429 m/sec; pressure ratio, 1.65) was used with each stator row. The design and analysis system is briefly described. The overall stage and rotor performances with each stator are compared, as are selected blade element data. The minimum overall efficiency decrement across the stator was approximately 1 percentage point greater with the CD blade sections than with the DCA blade sections.

  19. Development and validation of the Overlap Muon Track Finder for the CMS experiment

    NASA Astrophysics Data System (ADS)

    Dobosz, J.; Mietki, P.; Zawistowski, K.; Żarnecki, G.

    2016-09-01

    Present article is a description of the authors contribution in upgrade and analysis of performance of the Level-1 Muon Trigger of the CMS experiment. The authors are students of University of Warsaw and Gdansk University of Technology. They are collaborating with the CMS Warsaw Group. This article summarises students' work presented during the Students session during the Workshop XXXVIII-th IEEE-SPIE Joint Symposium Wilga 2016. In the first section the CMS experiment is briefly described and the importance of the trigger system is explained. There is also shown basic difference between old muon trigger strategy and the upgraded one. The second section is devoted to Overlap Muon Track Finder (OMTF). This is one of the crucial components of the Level-1 Muon Trigger. The algorithm of OMTF is described. In the third section there is discussed one of the event selection aspects - cut on the muon transverse momentum pT . Sometimes physical muon with pT bigger than a certain threshold is unnecessarily cut and physical muon with lower pT survives. To improve pT selection modified algorithm was proposed and its performance was studied. One of the features of the OMTF is that one physical muon often results in several muon candidates. The Ghost-Buster algorithm is designed to eliminate surplus candidates. In the fourth section this algorithm and its performance on different data samples are discussed. In the fifth section Local Data Acquisition System (Local DAQ) is briefly described. It supports initial system commissioning. The test done with OMTF Local DAQ are described. In the sixth section there is described development of web application used for the control and monitoring of CMS electronics. The application provides access to graphical user interface for manual control and the connection to the CMS hierarchical Run Control.

  20. Polarized radiation diagnostics of stellar magnetic fields

    NASA Astrophysics Data System (ADS)

    Mathys, Gautier

    The main techniques used to diagnose magnetic fields in stars from polarimetric observations are presented. First, a summary of the physics of spectral line formation in the presence of a magnetic field is given. Departures from the simple case of linear Zeeman effect are briefly considered: partial Paschen-Back effect, contribution of hyperfine structure, and combined Stark and Zeeman effects. Important approximate solutions of the equation of transfer of polarized light in spectral lines are introduced. The procedure for disk-integration of emergent Stokes profiles, which is central to stellar magnetic field studies, is described, with special attention to the treatment of stellar rotation. This formalism is used to discuss the determination of the mean longitudinal magnetic field (through the photographic technique and through Balmer line photopolarimetry). This is done within the specific framework of Ap stars, which, with their unique large-scale organized magnetic fields, are an ideal laboratory for studies of stellar magnetism. Special attention is paid to those Ap stars whose magnetically split line components are resolved in high-dispersion Stokes I spectra, and to the determination of their mean magnetic field modulus. Various techniques of exploitation of the information contained in polarized spectral line profiles are reviewed: the moment technique (in particular, the determination of the crossover and of the mean quadratic field), Zeeman-Doppler imaging, and least-squares deconvolution. The prospects that these methods open for linear polarization studies are sketched. The way in which linear polarization diagnostics complement their Stokes I and V counterparts is emphasized by consideration of the results of broad band linear polarization measurements. Illustrations of the use of various diagnostics to derive properties of the magnetic fields of Ap stars are given. This is used to show the interest of deriving more physically realistic models of the geometric structure of these fields. How this can possibly be achieved is briefly discussed. An overview of the current status of polarimetric studies of magnetic fields in non-degenerate stars of other types is presented. The final section is devoted to magnetic fields of white dwarfs. Current knowledge of magnetic fields of isolated white dwarfs is briefly reviewed. Diagnostic techniques are discussed, with particular emphasis on the variety of physical processes to be considered for understanding of spectral line formation over the broad range of magnetic field strengths encountered in these stars.

  1. On the Genealogy of Tissue Engineering and Regenerative Medicine

    PubMed Central

    2015-01-01

    In this article, we identify and discuss a timeline of historical events and scientific breakthroughs that shaped the principles of tissue engineering and regenerative medicine (TERM). We explore the origins of TERM concepts in myths, their application in the ancient era, their resurgence during Enlightenment, and, finally, their systematic codification into an emerging scientific and technological framework in recent past. The development of computational/mathematical approaches in TERM is also briefly discussed. PMID:25343302

  2. Maps, books and other metaphors for systems biology.

    PubMed

    Ouzounis, Christos; Mazière, Pierre

    2006-07-01

    We briefly review the use of metaphors in science and progressively focus on fields from biology and molecular biology to genomics and bioinformatics. We discuss how metaphors are both a tool for scientific exploration and a medium for public communication of complex subjects, by various short examples. Finally, we propose a metaphor for systems biology that provides an illuminating perspective for the ambitious goals of this field and delimits its current agenda.

  3. Changing patterns of migration in the Adriatic region.

    PubMed

    Schatzer, P

    1988-06-01

    International migration in the Adriatic countries of Albania, Greece, Italy, San Marino, and Yugoslavia is briefly examined using data from official and other published sources. The main types of migratory movements identified by the author within the region are "1) economically motivated migration (legal and clandestine); 2) immigration of refugees for resettlement; 3) immigration with the scope of final resettlement in a third country (transit movements); [and] 4) return migration by former emigrants." excerpt

  4. Podoconiosis, non-filarial elephantiasis, and lymphology.

    PubMed

    Davey, G

    2010-12-01

    Several recent reviews of podoconiosis already exist in journals and on public access websites. After briefly covering the historical and epidemiological background, this narrative review will therefore attempt explicitly to link podoconiosis with lymphology, examining gaps in what is known of pathogenesis and identifying the areas of research in which input from lymphologists is most required. Finally, prevention and treatment will be described and the need for operational research to optimize community-based interventions outlined.

  5. Dynamic bin packing problem

    NASA Technical Reports Server (NTRS)

    Dikshit, Piyush; Guimaraes, Katia; Ramamurthy, Maya; Agrawala, Ashok K.; Larsen, Ronald L.

    1989-01-01

    In a previous work we have defined a general architecture model for autonomous systems, which can be mapped easily to describe the functions of any automated system (SDAG-86-01). In this note, we use the model to describe the problem of thermal management in space stations. First we briefly review the architecture, then we present the environment of our application, and finally we detail the specific function for each functional block of the architecture for that environment.

  6. STS-3 Induced Environment Contamination Monitor (IECM): Quick-look report

    NASA Technical Reports Server (NTRS)

    Miller, E. R. (Editor); Fountain, J. A. (Editor)

    1982-01-01

    The STS-3/Induced Environment Contamination Monitor (IECM) mission is described. The IECM system performance is discussed, and IECM mission time events are briefly described. Quick look analyses are presented for each of the 10 instruments comprising the IECM on the flight of STS-3. Finally, a short summary is presented and plans are discussed for future IECM flights, and opportunities for direct mapping of Orbiter effluents using the Remote manipulator System.

  7. Virtual volatility

    NASA Astrophysics Data System (ADS)

    Silva, A. Christian; Prange, Richard E.

    2007-03-01

    We introduce the concept of virtual volatility. This simple but new measure shows how to quantify the uncertainty in the forecast of the drift component of a random walk. The virtual volatility also is a useful tool in understanding the stochastic process for a given portfolio. In particular, and as an example, we were able to identify mean reversion effect in our portfolio. Finally, we briefly discuss the potential practical effect of the virtual volatility on an investor asset allocation strategy.

  8. On the genealogy of tissue engineering and regenerative medicine.

    PubMed

    Kaul, Himanshu; Ventikos, Yiannis

    2015-04-01

    In this article, we identify and discuss a timeline of historical events and scientific breakthroughs that shaped the principles of tissue engineering and regenerative medicine (TERM). We explore the origins of TERM concepts in myths, their application in the ancient era, their resurgence during Enlightenment, and, finally, their systematic codification into an emerging scientific and technological framework in recent past. The development of computational/mathematical approaches in TERM is also briefly discussed.

  9. Imaging Oncogene Expression

    PubMed Central

    Mukherjee, Archana; Wickstrom, Eric

    2009-01-01

    This review briefly outlines the importance of molecular imaging, particularly imaging of endogenous gene expression for noninvasive genetic analysis of radiographic masses. The concept of antisense imaging agents and the advantages and challenges in the development of hybridization probes for in vivo imaging are described. An overview of the investigations on oncogene expression imaging is given. Finally, the need for further improvement in antisense-based imaging agents and directions to improve oncogene mRNA targeting is stated. PMID:19264436

  10. Computerizing Audit Studies

    PubMed Central

    Lahey, Joanna N.; Beasley, Ryan A.

    2014-01-01

    This paper briefly discusses the history, benefits, and shortcomings of traditional audit field experiments to study market discrimination. Specifically it identifies template bias and experimenter bias as major concerns in the traditional audit method, and demonstrates through an empirical example that computerization of a resume or correspondence audit can efficiently increase sample size and greatly mitigate these concerns. Finally, it presents a useful meta-tool that future researchers can use to create their own resume audits. PMID:24904189

  11. Current and anticipated uses of thermal-hydraulic codes in NFI

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tsuda, K.; Takayasu, M.

    1997-07-01

    This paper presents the thermal-hydraulic codes currently used in NFI for the LWR fuel development and licensing application including transient and design basis accident analyses of LWR plants. The current status of the codes are described in the context of code capability, modeling feature, and experience of code application related to the fuel development and licensing. Finally, the anticipated use of the future thermal-hydraulic code in NFI is briefly given.

  12. Reflections on a Visit to the Union of the Blind of Croatia, Zagreb, Yugoslavia.

    ERIC Educational Resources Information Center

    Cylke, Frank Kurt; Hanke, Peter

    The paper reports a visit to the Union of the Blind in Croatia, an organization serving the needs of 4,500 blind individuals in this part of Yugoslavia. Briefly considered are personnel, financial support, and services (such as braille and talking book production). A separate section describes the organization's library, recorded and braille…

  13. "Military Teens on the Move": An Internet Resource for Military Youth Facing Relocation.

    ERIC Educational Resources Information Center

    Wright, Mareena McKinley; Schaffer, Rebecca; Coolbaugh, Kathleen; Bowen, Gary; Wiley, Gina

    With the "Military Teens On The Move" (MTOM) Web site, the Office of Family Policy has implemented an innovative approach to providing relocation support for military families and children via the Internet. This paper briefly describes the design team's efforts to design, develop, and implement MTOM. The first section of the paper describes the…

  14. Project APPLE CORE. Annual Report, July 1, 1975 to September 30, 1975.

    ERIC Educational Resources Information Center

    Louisiana State Dept. of Education, Baton Rouge.

    Project Apple Core (Adult Performance Level), a 15-month project funded through Section 309 of the Adult Education Act of 1966, was carried out in Lafayette Parish, Louisiana, to provide a career-oriented instructional program for undereducated and underemployed adults in that area. The document briefly describes some aspects of the project, in…

  15. A Writer's Reference. Third Edition.

    ERIC Educational Resources Information Center

    Hacker, Diana

    Designed to save the user time and packaged in a compact size which lies flat, this book is easy to consult while revising and editing a written draft. The book's "main menu," just inside the front cover, displays the contents as briefly and simply as possible. Each of the 12 sections in the book's main menu leads the user to a tabbed…

  16. AID: The New Challenge. A Special Report of the Agency for International Development.

    ERIC Educational Resources Information Center

    Agency for International Development (Dept. of State), Washington, DC.

    The programs and policies of the Agency for International Development (AID) in administering American foreign aid are briefly described in this booklet. Short introductory sections discuss the reasons for foreign aid, the interdependence of today's world, and the history of American foreign aid since World War II. The remaining parts of the…

  17. Cross-Cultural Communications in the Classroom: An Annotated Bibliography of Films and Videos, 1985.

    ERIC Educational Resources Information Center

    Zanger, Virginia Vogel, Comp.

    This list of 19 films and videotape recordings was developed in response to teacher requests for practical methods and materials for teaching about cultural similarities and differences. An introductory section briefly discusses classroom teaching about cross-cultural issues and the potential uses of the films included in the list. Indexes list…

  18. Adaptation and Integration of Recent Refugees to the United States.

    ERIC Educational Resources Information Center

    Forbes, Susan S.

    This booklet is an overview report on refugee integration and adaptation in the United States. The introduction discusses briefly the Refugee Act of 1980, and is followed by three sections of text. The first part summarizes information on the extent of refugee economic and social adjustment and analyzes factors that have facilitated and impeded…

  19. EUDISED: European Documentation and Information System for Education. Volume II, National Reports.

    ERIC Educational Resources Information Center

    Council of Europe, Strasbourg (France). Documentation Center for Education in Europe.

    This study briefly describes the documentation and information projects of seven nations, stressing their use in the field of education. The sections are: (1) automated documentation and the human sciences in France, (2) documentation for education and the social sciences in the Federal Republic of Germany, (3) mechanized projects in library work…

  20. Changing Financial Provision Leads to a Radical Reform of the English Education System.

    ERIC Educational Resources Information Center

    Davies, Brent; Ellison, Linda

    This paper discusses the recent implementation in England of school improvement reforms based on school choice and in particular on a system of school-based management whereby total financial control is vested in individual schools. The first section briefly describes the financial structure of the English educational system, followed by an…

  1. Scaling Cross Sections for Ion-atom Impact Ionization

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Igor D. Kaganovich; Edward Startsev; Ronald C. Davidson

    2003-06-06

    The values of ion-atom ionization cross sections are frequently needed for many applications that utilize the propagation of fast ions through matter. When experimental data and theoretical calculations are not available, approximate formulas are frequently used. This paper briefly summarizes the most important theoretical results and approaches to cross section calculations in order to place the discussion in historical perspective and offer a concise introduction to the topic. Based on experimental data and theoretical predictions, a new fit for ionization cross sections is proposed. The range of validity and accuracy of several frequently used approximations (classical trajectory, the Born approximation,more » and so forth) are discussed using, as examples, the ionization cross sections of hydrogen and helium atoms by various fully stripped ions.« less

  2. Experimental Study of Tip Vortex Flow from a Periodically Pitched Airfoil Section

    NASA Technical Reports Server (NTRS)

    Zaman, Khairul; Fagan, Amy; Mankbadi, Mina

    2016-01-01

    An experimental investigation of tip vortex flow from a NACA0012 airfoil, pitched periodically at various frequencies, is conducted in a low-speed wind tunnel. Initially, data for stationary airfoil held fixed at various angles-of-attack are gathered. Flow visualization pictures as well as detailed cross-sectional properties areobtained at various streamwise locations using hot-wire anemometry. Data include mean velocity, streamwise vorticity as well as various turbulent stresses. Preliminary data are also acquired for periodically pitched airfoil. These results are briefly presented in this extended abstract.

  3. Kuang's Semi-Classical Formalism for Calculating Electron Capture Cross Sections: A Space- Physics Application

    NASA Technical Reports Server (NTRS)

    Barghouty, A. F.

    2014-01-01

    Accurate estimates of electroncapture cross sections at energies relevant to the modeling of the transport, acceleration, and interaction of energetic neutral atoms (ENA) in space (approximately few MeV per nucleon) and especially for multi-electron ions must rely on detailed, but computationally expensive, quantum-mechanical description of the collision process. Kuang's semi-classical approach is an elegant and efficient way to arrive at these estimates. Motivated by ENA modeling efforts for apace applications, we shall briefly present this approach along with sample applications and report on current progress.

  4. Analysis of reaction cross-section production in neutron induced fission reactions on uranium isotope using computer code COMPLET.

    PubMed

    Asres, Yihunie Hibstie; Mathuthu, Manny; Birhane, Marelgn Derso

    2018-04-22

    This study provides current evidence about cross-section production processes in the theoretical and experimental results of neutron induced reaction of uranium isotope on projectile energy range of 1-100 MeV in order to improve the reliability of nuclear stimulation. In such fission reactions of 235 U within nuclear reactors, much amount of energy would be released as a product that able to satisfy the needs of energy to the world wide without polluting processes as compared to other sources. The main objective of this work is to transform a related knowledge in the neutron-induced fission reactions on 235 U through describing, analyzing and interpreting the theoretical results of the cross sections obtained from computer code COMPLET by comparing with the experimental data obtained from EXFOR. The cross section value of 235 U(n,2n) 234 U, 235 U(n,3n) 233 U, 235 U(n,γ) 236 U, 235 U(n,f) are obtained using computer code COMPLET and the corresponding experimental values were browsed by EXFOR, IAEA. The theoretical results are compared with the experimental data taken from EXFOR Data Bank. Computer code COMPLET has been used for the analysis with the same set of input parameters and the graphs were plotted by the help of spreadsheet & Origin-8 software. The quantification of uncertainties stemming from both experimental data and computer code calculation plays a significant role in the final evaluated results. The calculated results for total cross sections were compared with the experimental data taken from EXFOR in the literature, and good agreement was found between the experimental and theoretical data. This comparison of the calculated data was analyzed and interpreted with tabulation and graphical descriptions, and the results were briefly discussed within the text of this research work. Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

  5. Understanding young stars - A history

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Stahler, S.W.

    1988-12-01

    The history of pre-main-sequence theory is briefly reviewed. The paper of Henyey et al. (1955) is seen as an important transitional work, one which abandoned previous simplifying assumptions yet failed to incorporate newer insights into the surface structure of late-type stars. The subsequent work of Hayashi and his contemporaries is outlined, with an emphasis on the underlying physical principles. Finally, the recent impact of protostar theory is discussed, and speculations are offered on future developments. 56 references.

  6. Applications of biomaterials in plastic surgery.

    PubMed

    Kim, Jeff J; Evans, Gregory R D

    2012-10-01

    The expansion of the application of biomaterials in plastic surgery has led to the increased availability of commercial products in recent years. This overview discusses soft tissue fillers, bioengineered skins, acellular dermal matrices, biomaterials for craniofacial surgery, and peripheral nerve repair. We summarize indications, properties, uses, types, advantages and disadvantages of some of the currently available products from each category. Finally, the current state of development in drug delivery system is also briefly summarized. Published by Elsevier Inc.

  7. Overview of MSFC AMSD Integrated Modeling and Analysis

    NASA Technical Reports Server (NTRS)

    Cummings, Ramona; Russell, Kevin (Technical Monitor)

    2002-01-01

    Structural, thermal, dynamic, and optical models of the NGST AMSD mirror assemblies are being finalized and integrated for predicting cryogenic vacuum test performance of the developing designs. Analyzers in use by the MSFC Modeling and Analysis Team are identified, with overview of approach to integrate simulated effects. Guidelines to verify the individual models and calibration cases for comparison with the vendors' analyses are presented. In addition, baseline and proposed additional scenarios for the cryogenic vacuum testing are briefly described.

  8. Adapting a Navier-Stokes code to the ICL-DAP

    NASA Technical Reports Server (NTRS)

    Grosch, C. E.

    1985-01-01

    The results of an experiment are reported, i.c., to adapt a Navier-Stokes code, originally developed on a serial computer, to concurrent processing on the CL Distributed Array Processor (DAP). The algorithm used in solving the Navier-Stokes equations is briefly described. The architecture of the DAP and DAP FORTRAN are also described. The modifications of the algorithm so as to fit the DAP are given and discussed. Finally, performance results are given and conclusions are drawn.

  9. From the Law of Large Numbers to Large Deviation Theory in Statistical Physics: An Introduction

    NASA Astrophysics Data System (ADS)

    Cecconi, Fabio; Cencini, Massimo; Puglisi, Andrea; Vergni, Davide; Vulpiani, Angelo

    This contribution aims at introducing the topics of this book. We start with a brief historical excursion on the developments from the law of large numbers to the central limit theorem and large deviations theory. The same topics are then presented using the language of probability theory. Finally, some applications of large deviations theory in physics are briefly discussed through examples taken from statistical mechanics, dynamical and disordered systems.

  10. Future and outlook: Where are we, and where will the spatial information management in wildlife ecology be in 50 years from now? [Chapter 24

    Treesearch

    Samuel A. Cushman; Falk Huettmann

    2010-01-01

    In this final chapter we briefly look back over what we have attempted in this book, and then look toward the future to discuss the outlook for overcoming the challenges we face within our fields of ecological science and in the greater application of this knowledge to enhance the prospect for a sustainable future for the biosphere. Looking back, we have tried...

  11. MACROMOLECULAR THERAPEUTICS

    PubMed Central

    Yang, Jiyuan; Kopeček, Jindřich

    2014-01-01

    This review covers water-soluble polymer-drug conjugates and macromolecules that possess biological activity without attached low molecular weight drugs. The main design principles of traditional and backbone degradable polymer-drug conjugates as well as the development of a new paradigm in nanomedicines – (low molecular weight) drug-free macromolecular therapeutics are discussed. To address the biological features of cancer, macromolecular therapeutics directed to stem/progenitor cells and the tumor microenvironment are deliberated. Finally, the future perspectives of the field are briefly debated. PMID:24747162

  12. EMMA, a Recoil Mass Spectrometer for TRIUMF's ISAC-II Facility

    NASA Astrophysics Data System (ADS)

    Davids, Barry; EMMA Collaboration

    2016-09-01

    EMMA is a recoil mass spectrometer for TRIUMF's ISAC-II facility in the final stages of installation and commissioning. In this talk I will briefly review the spectrometer's design capabilities, describe recent progress in its installation and commissioning, and discuss plans for its initial experimental program. This work was supported by the Natural Sciences and Engineering Council of Canada. TRIUMF receives federal funds through a contribution agreement with the National Research Council of Canada.

  13. Endocarditis and Stroke

    PubMed Central

    GRECU, Nicolae; TIU, Cristina; TERECOASA, Elena; BAJENARU, Ovidiu

    2014-01-01

    Endocarditis is an important, although less common, cause of cerebral embolism. All forms of endocarditis share an initial common pathophysiologic pathway, best illustrated by the non-bacterial thrombotic form, but also a final potential for embolization. Stroke associated with endocarditis has signifficant mortality and morbidity rates, especially due to the frequent concomitant multiple sites of brain embolization. In this article we aim to briefly review endocarditis with a focus on stroke as a complication, while also presenting case correlates from our department. PMID:25705308

  14. Enantioseparations by capillary electrochromatography.

    PubMed

    Fanali, S; Catarcini, P; Blaschke, G; Chankvetadze, B

    2001-09-01

    The review summarizes recent developments in enantioseparations by capillary electrochromatography (CEC). Selected fundamental aspects of CEC are discussed in order to stress those features which may allow the success of this technique in the competitive field of enantioseparations. In addition, the comparative characteristics of the different modes of chiral CEC and the stationary phases are presented. The effects of the characteristics of the stationary and liquid phases and operational conditions on the separation results are discussed. Finally, some future trends are briefly addressed.

  15. What is currently known about the genetics of venous thromboembolism at the dawn of next generation sequencing technologies.

    PubMed

    Trégouët, David-Alexandre; Morange, Pierre-Emmanuel

    2018-02-01

    Venous thromboembolism (VTE) has a strong genetic component. This review summarizes what is known at the seventeen genes that are now well established to harbour VTE-associated genetic variants. In addition, it discusses additional candidate genes that deserve further validation before being claimed as VTE associated genes. Finally, several research strategies are briefly described to identify other molecular determinants of the disease. © 2017 John Wiley & Sons Ltd.

  16. Translations on USSR Military Affairs, Number 1276

    DTIC Science & Technology

    1977-05-16

    organized this for them and this .... And they are still bored." We have invited artists for them. We have showed them new movies. We have conducted...with them, Incidently, not all sergeants are able to do the manual by the numbers well on the gymnastic equipment. Finally, the specifics of the...athletics and gymnastics have been excluded from the program as atypical types of sports for the navy," was his opinion. Briefly and clearly they are

  17. Migrant Child Welfare: A State of the Field Study of Child Welfare Services for Migrant Children and Their Families Who Are In-Stream, Home Based, Or Settled-Out. Final Report, June 1977.

    ERIC Educational Resources Information Center

    Cavenaugh, David N.; And Others

    The five parts of this report present the findings and recommendations of the Migrant Child Welfare study. Part I briefly summarizes the impact of the child welfare services and the family interview results, and reviews the organizational structure of program delivery at the state and local levels. Part II synthesizes the information obtained from…

  18. Total absorption cross sections of several gases of aeronomic interest at 584 A.

    NASA Technical Reports Server (NTRS)

    Starr, W. L.; Loewenstein, M.

    1972-01-01

    Total photoabsorption cross sections have been measured at 584.3 A for N2, O2, Ar, CO2, CO, NO, N2O, NH3, CH4, H2, and H2S. A monochromator was used to isolate the He I 584 line produced in a helium resonance lamp, and thin aluminum filters were used as absorption cell windows, thereby eliminating possible errors associated with the use of undispersed radiation or windowless cells. Sources of error are examined, and limits of uncertainty are given. Previous relevant cross-sectional measurements and possible error sources are reviewed. Wall adsorption as a source of error in cross-sectional measurements has not previously been considered and is discussed briefly.

  19. Methods for computing internal flattening, with applications to the Earth's structure and geodynamics

    NASA Astrophysics Data System (ADS)

    Denis, C.; Amalvict, M.; Rogister, Y.; Tomecka-Suchoń, S.

    1998-03-01

    After general comments (Section 1) on using variational procedures to compute the oblateness of internal strata in the Earth and slowly rotating planets, we recall briefly some basic concepts about barotropic equilibrium figures (Section 2), and then proceed to discuss several accurate methods to derive the internal flattening. The algorithms given in Section 3 are based on the internal gravity field theory of Clairaut, Laplace and Lyapunov. They make explicit use of the concept of a level surface. The general formulation given here leads to a number of formulae which are of both theoretical and practical use in studying the Earth's structure, dynamics and rotational evolution. We provide exact solutions for the figure functions of three Earth models, and apply the formalism to yield curves for the internal flattening as a function of the spin frequency. Two more methods, which use the general deformation equations, are discussed in Section 4. The latter do not rely explicitly on the existence of level surfaces. They offer an alternative to the classical first-order internal field theory, and can actually be used to compute changes of the flattening on short timescales produced by variations in the LOD. For short durations, the Earth behaves elastically rather than hydrostatically. We discuss in some detail static deformations and Longman's static core paradox (Section 5), and demonstrate that in general no static solution exists for a realistic Earth model. In Section 6 we deal briefly with differential rotation occurring in cylindrical shells, and show why differential rotation of the inner core such as has been advocated recently is incompatible with the concept of level surfaces. In Section 7 we discuss first-order hydrostatic theory in relation to Earth structure, and show how to derive a consistent reference Earth model which is more suitable for geodynamical modelling than are modern Earth models such as 1066-A, PREM or CORE11. An important result is that a consistent application of hydrostatic theory leads to an inertia factor of about 0.332 instead of the value 0.3308 used until now. This change automatically brings `hydrostatic' values of the flattening, the dynamic shape factor and the precessional constant into much better agreement with their observed counterparts than has been assumed hitherto. Of course, we do not imply that non-hydrostatic effects are unimportant in modelling geodynamic processes. Finally, we discuss (Sections 7-8) some implications of our way of looking at things for Earth structure and some current problems of geodynamics. We suggest very significant changes for the structure of the core, in particular a strong reduction of the density jump at the inner core boundary. The theoretical value of the free core nutation period, which may be computed by means of our hydrostatic Earth models CGGM or PREMM, is in somewhat better agreement with the observed value than that based on PREM or 1066-A, although a significant residue remains. We attribute the latter to inadequate modelling of the deformation, and hence of the change in the inertia tensor, because the static deformation equations were used. We argue that non-hydrostatic effects, though present, cannot explain the large observed discrepancy of about 30 days.

  20. 40 CFR Appendix D to Part 97 - Final Section 126 Rule: State Compliance supplement pools for the Section 126 Final Rule (Tons)

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Final Section 126 Rule: State Compliance supplement pools for the Section 126 Final Rule (Tons) D Appendix D to Part 97 Protection of... PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS Pt. 97, App. D Appendix D to Part 97—Final Section 126 Rule...

  1. Cross sections for n+{sup 14}N from an R-matrix analysis of the {sup 15}N system

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hale, G.M.; Young, P.G.; Chadwick, M.B.

    1994-06-01

    As part of the Hiroshima-Nagasaki Dose Reevaluation Program, a new evaluation of the neutron cross sections for {sup 14}N was made for ENDF/B-VI, based at energies below 2.5 MeV on a multichannel R-matrix analysis of reactions in the {sup 15}N system. The types of data used in the analysis, and the resulting cross sections and resonance structure for {sup 15}N are briefly described. The resonant features of the neutron cross sections were especially well determined by including precise, high-resolution neutron total cross section measurements from ORNL. While the new evaluated cross section appear to be significant improvements over the earliermore » ones, they still need to be tested more extensively against recent measurements of the differential elastic cross section from Oak Ridge.« less

  2. Orthopaedic service lines-revisited.

    PubMed

    Patterson, Cheryl

    2008-01-01

    This article revisits the application of orthopaedic service lines from early introduction and growth of this organizational approach in the 1980s, through the 1990s, and into the current decade. The author has experienced and worked in various service-line structures through these three decades, as well as the preservice-line era of 1970s orthopaedics. Past lessons learned during earlier phases and then current trends and analysis by industry experts are summarized briefly, with indication given of the future for service lines. Variation versus consistency of certain elements in service-line definitions and in operational models is discussed. Main components of service-line structures and typical processes are described briefly, along with a more detailed section on the service-line director/manager role. Current knowledge contained here will help guide the reader to more "out-of-the-box" thinking toward comprehensive orthopaedic centers of excellence.

  3. Macro-microscopic anatomy: obtaining a composite view of barrier zone formation in Acer saccharum

    Treesearch

    Kenneth Dudzik

    1988-01-01

    The technique for constructing a montage of large wood sections cut on a sliding microtome is discussed. Briefly, the technique involves photographing many serial micrographs in a pattern under a light microscope similar to the way flight lines are run in aerial photography. Assembly of the resulting overlapping photographs requires careful trimming. A composite of...

  4. Sourcebook for Sex Equality: Small Presses. An Annotated Listing of Small Presses and Alternative Sources for Books and Media. Bibliographic Series, 1.

    ERIC Educational Resources Information Center

    Hulme, Marylin A., Comp.

    This briefly annotated guide to non-sexist and non-racist educational materials suppliers includes small presses, non-profit educational firms, women's sections of professional and trade organizations, task forces in State educational departments, and feminist publishers, bookstores and distributors. Aimed at assisting librarians and teachers in…

  5. Survey of Political Participation, Employment and Demographic Characteristics of Eleven Counties in Southern New Mexico. Volume I.

    ERIC Educational Resources Information Center

    New Mexico State Advisory Committee to the U.S. Commission on Civil Rights, Santa Fe.

    The report briefly outlines the population characteristics, public employment and political representation status of the Chaves, Curry, Eddy, Lea, and Roosevelt counties in southern New Mexico for a 10-year period. The three sections of each profile focus on the county government, largest city in that county, and school district encompassing that…

  6. Survey of Political Participation, Employment, and Demographic Characteristics of Eleven Counties in Southern New Mexico. Volume II.

    ERIC Educational Resources Information Center

    New Mexico State Advisory Committee to the U.S. Commission on Civil Rights, Santa Fe.

    The report briefly outlines the population characteristics, public employment and political representation status of the Dona Ana, Grant, Hidalgo, Luna, Otero, and Sierra counties in southern New Mexico for a 10-year period. The three sections of each profile focus on the city government, largest city in that county, and school district…

  7. Missed by the Mass Media: The Houma, Pointe-au-Chien, and Hurricanes Katrina and Rita

    ERIC Educational Resources Information Center

    Collins, Robert Keith

    2008-01-01

    This case study investigates the media discourse from Houma and Pointe-au-Chien tribal leaders in Louisiana on their experiences with Hurricanes Katrina and Rita. One section briefly engages the discourse as discernable from the reports found in Native American and non-Native American news media. Included is a brief yet close examination of these…

  8. Your School and Your Rights: Discrimination against Children with Diabetes in the Public School System.

    ERIC Educational Resources Information Center

    Sterling, Beth

    This leaflet provides the parents of children with diabetes an overview of education legislation that affects the education of their child. The guide briefly explains the Individuals with Disabilities Education Act (IDEA) and Section 504 of the Rehabilitation Act 1973, the rights of the parent or legal guardian of a child with diabetes, such as…

  9. Seadust wildlife controllant and other techniques to protect forest plantations

    Treesearch

    Dan L. Campbell; Brooke K. Campbell; Clinton L. Campbell

    2007-01-01

    We briefly review some of the materials and methods used for reducing wildlife damage to forest crops. Many of these have also been used to protect Christmas trees, ornamentals, and other agricultural crops. Few chemicals have been effective as repellents, and few are exempted from registration by the Environmental Protection Agency (EPA) under Section 25(b) of the...

  10. The Breakup of the Soviet Union and How It Will Affect U.S. Foreign Policy [and] Teacher's Guide.

    ERIC Educational Resources Information Center

    Walker, Tim

    This student booklet and teacher's guide examine the causes and the aftermath of the disintegration of the Soviet Union. The first two sections of the student booklet briefly summarize the Cold War and describe the unfulfilled promises of Mikhail Gorachev's "perestroika," the rising discontent among the people, and the birth of…

  11. The Open Admissions Story; 1970 At the City University of New York.

    ERIC Educational Resources Information Center

    City Univ. of New York, NY. Office of Univ. Relations.

    This report briefly reviews the history of the open admissions policy at the City University of New York, which offers admission to all New York City high school students graduated in June 1970 and thereafter to some college or center of the University, effective September 1970. The report consists of six sections: (1) The Decision for Open…

  12. Sociological Health Problems: Individualized Incentive Program Modules for Physically Disabled Students for Grades Kindergarten Through Twelve. Teacher's Edition.

    ERIC Educational Resources Information Center

    Reggio, Kathryn D.; And Others

    Presented is the second in a series of modules from a project to adapt the New York State Health Education curriculum for physically disabled students (grades K-12). An introductory section to the volume on sociological health problems provides definitions and summaries about nine physically disabling conditions and briefly considers activities at…

  13. A SHORT HISTORY CSISRS - AT THE CUTTING EDGE OF NUCLEAR DATA INFORMATION STORAGE AND RETRIEVAL SYSTEMS AND ITS RELATIONSHIP TO CINDA, EXFOR AND ENDF.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    HOLDEN, N.E.

    A short history of CSISRS, pronounced ''scissors'' and standing for the Cross Section Information Storage and Retrieval System, is given. The relationship of CSISRS to CINDA, to the neutron nuclear data four-centers, to EXFOR and to ENDF, the evaluated neutron nuclear data file, is briefly explained.

  14. Notes on modeling and simulation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Redondo, Antonio

    These notes present a high-level overview of how modeling and simulation are carried out by practitioners. The discussion is of a general nature; no specific techniques are examined but the activities associated with all modeling and simulation approaches are briefly addressed. There is also a discussion of validation and verification and, at the end, a section on why modeling and simulation are useful.

  15. The Collaboration to Improve Reading in the Content Areas (The CIRCA Project). Reading Education Report No. 65.

    ERIC Educational Resources Information Center

    Armbruster, Bonnie B.; And Others

    The Collaboration to Improve Reading in the Content Areas (CIRCA) project, a collaborative effort between the Center for the Study of Reading and the Chicago Public Schools, is described in this paper. Noting that the project was designed to translate research about content area reading into practice, the first section briefly discusses the…

  16. Chemical Dependency Unit: One Aspect of the Program for Student Assistance of Bryan Sr. High School. Teacher Manual.

    ERIC Educational Resources Information Center

    Omaha Public Schools, NE.

    This teachers manual provides three instructional units (Chemical Dependency, A Disease; The Family; and Intervention and Recovery) for chemical dependency education at the high school level. The history, objectives, and teaching philosophy of the program are discussed briefly, and a course syllabus outline and audiovisual aids list by section are…

  17. Interplanetary Mission Design Handbook: Earth-to-Mars Mission Opportunities and Mars-to-Earth Return Opportunities 2009-2024

    NASA Technical Reports Server (NTRS)

    George, L. E.; Kos, L. D.

    1998-01-01

    This paper provides information for trajectory designers and mission planners to determine Earth-Mars and Mars-Earth mission opportunities for the years 2009-2024. These studies were performed in support of a human Mars mission scenario that will consist of two cargo launches followed by a piloted mission during the next opportunity approximately 2 years later. "Porkchop" plots defining all of these mission opportunities are provided which include departure energy, departure excess speed, departure declination arrival excess speed, and arrival declinations for the mission space surrounding each opportunity. These plots are intended to be directly applicable for the human Mars mission scenario described briefly herein. In addition, specific trajectories and several alternate trajectories are recommended for each cargo and piloted opportunity. Finally, additional studies were performed to evaluate the effect of various thrust-to-weight ratios on gravity losses and total time-of-flight tradeoff, and the resultant propellant savings and are briefly summarized.

  18. Analysis of DNA-chip and antigen-chip data: studies of cancer, stem cells and autoimmune diseases

    NASA Astrophysics Data System (ADS)

    Domany, Eytan

    2005-07-01

    Biology has undergone a revolution during the past decade. Deciphering the human genome has opened new horizons, among which the advent of DNA microarrays has been perhaps the most significant. These miniature measuring devices report the levels at which tens of thousands of genes are expressed in a collection of cells of interest (such as tissue from a tumor). I describe here briefly this technology and present an example of how analysis of data obtained from such high throughput experiments provides insights of possible clinical and therapeutic relevance for Acute Lymphoblastic Leukemia. Next, I describe how gene expression data is used to deduce a new design principle, " Just In Case", used by stem cells. Finally I briefly review a different novel technology, of antigen chips, which provide a fingerprint of a subject's immune system and may become a predictive clinical tool. The work reviewed here was done in collaboration with numerous colleagues and students.

  19. The protons of space and brain tumors II. Cellular and molecular considerations

    NASA Astrophysics Data System (ADS)

    Nagle, W. A.; Moss, A. J.; Dalrymple, G. V.; Cox, A. B.; Wigle, J. F.; Mitchell, J. C.

    1989-05-01

    An increased incidence of highly malignant gliomas, termed glioblastoma multiforme has been observed in Rhesus monkeys irradiated with 55 MeV protons, and in humans treated with therapeutic irradiation to the head. The results suggest a radiation etiology for these tumors. In this paper, we review briefly some characteristics of glioma tumors, and summarize the genetic changes associated with malignant gliomas in experimental animals and in humans. The genetic abnormalities include cytogenetic alterations, and changes in the structure and expression of specific oncogenes. We discuss the potential for these genetic changes to contribute to several putative mechanism leading to aberrant growth stimulation and, ultimately, to tumorigenesis. In addition, we review briefly some recent data concerning the molecular nature of radiation-induced somatic cell mutation and oncogene activation, and discuss the significance of these results for the radiation etiology of malignant gliomas. Finally, some implications of these results are discussed in relation to human radiation exposure in space.

  20. [Laboratory animals and official Mexican norms (NOM-062-ZOO-1999)].

    PubMed

    de Aluja, Aline S

    2002-01-01

    This article concerns animal experimentation and official Mexican norm Nom 0062-Zoo-1999 entitled Technical specifications for the production, care and use of laboratory animals. The history of animal experimentation is briefly resumed. During the nineteenth century, doubts arose as to the right to expose animals to experimental procedures that frequently cause pain and suffering. The first law which protected animals against cruelty was passed in Great Britain in 1876; subsequently, other nations approved similar legislation. During the second part of the twentieth century, opposition to animal experimentation grew. Other groups, mainly scientists and pharmaceutical concerns, defended the right to use animals in research. New knowledge concerning the neurophysiology, cognitive capacity, and the animal faculty to experience pain is briefly mentioned. Guidelines on care and use of animals used in research published in several countries are listed. Finally, the recently published Mexican legislation (Norm) referring to production, care and use of laboratory animals is discussed and its benefits are stressed.

  1. The accession countries benefit in the field of plant protection products.

    PubMed

    Stanek, A

    2004-04-01

    Ten candidate countries are expected to join EU in 2004. In the field of plant protection product (PPP) regulation, at EU level, acceding states will have roles in evaluation for listing of active substances in Annex I of Directive 91/414/EEC and ensuring that at national level, regulatory procedures comply with the acquis communautaire. This paper briefly outlines the impact of the acquis on the roles of Member States at both EU and national levels. It then briefly explains the current Czech Republic regulatory system as operated by the State Phytosanitary Administration and the National Institute of Public Health and the steps that the Czech Republic will have to take to implement the acquis requirements. Finally it makes an assessment as to how successful implementation of the acquis will prove beneficial to the acceding states and the parties which rely on the service that the regulatory authorities provide (i.e. the public, farmers and growers and the agrochemical industry).

  2. Chemical Loss of Polar Ozone: Present Understanding and Remaining Uncertainties

    NASA Technical Reports Server (NTRS)

    Salawitch, Ross; Canty, Tim; Cunnold, Derek; Dorf, Marcel; Frieler, Katja; Godin-Beekman, Sophie; Newchurch, Michael; Pfeilsticker, Klaus; Rex, Markus; Stimpfle, Rick; hide

    2005-01-01

    Not long after the discovery of the Antarctic ozone hole, it was established that halogen compounds, supplied to the atmosphere mainly by anthropogenic activities, are the primary driver of polar ozone loss. We will briefly review the chemical mechanisms that cause polar ozone loss and the early evidence showing the key role played by anthropogenic halogens. Recently, stratospheric halogen loading has leveled off, due to adherence to the Montreal Protocol and its amendments that has essentially banned CFCs (chlorofluorocarbons) and other halocarbons. We will describe recent reports of the first stage of recovery of the Antarctic ozone hole (e.g., a statistically significant slowing of the downward trend), associated with the leveling off of stratospheric halogens. Despite this degree of understanding, we will discuss the tendency of photochemical models to underestimate the observed rate of polar ozone loss and a hypothesis that has recently been put forth that might resolve this discrepancy. Finally, we will briefly discuss chemical loss of Arctic ozone, which

  3. WKB theory of large deviations in stochastic populations

    NASA Astrophysics Data System (ADS)

    Assaf, Michael; Meerson, Baruch

    2017-06-01

    Stochasticity can play an important role in the dynamics of biologically relevant populations. These span a broad range of scales: from intra-cellular populations of molecules to population of cells and then to groups of plants, animals and people. Large deviations in stochastic population dynamics—such as those determining population extinction, fixation or switching between different states—are presently in a focus of attention of statistical physicists. We review recent progress in applying different variants of dissipative WKB approximation (after Wentzel, Kramers and Brillouin) to this class of problems. The WKB approximation allows one to evaluate the mean time and/or probability of population extinction, fixation and switches resulting from either intrinsic (demographic) noise, or a combination of the demographic noise and environmental variations, deterministic or random. We mostly cover well-mixed populations, single and multiple, but also briefly consider populations on heterogeneous networks and spatial populations. The spatial setting also allows one to study large fluctuations of the speed of biological invasions. Finally, we briefly discuss possible directions of future work.

  4. Wind power live! An interactive exhibit and related programs about wind generated energy at the Science Museum of Minnesota. Final performance report, February 1, 1995--September 30, 1996

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hamilton, P.

    The final performance report for the Wind Power Live! museum exhibit summarizes the goals and outcomes for the project. Project goals included: (1) help museum visitors understand why wind is being considered as a significant energy source; (2) enable visualization of the dynamics and power output of turbines; (3) exhibit a working wind turbine; (4) showcase wind as a technological success story; (5) consider the environmental costs and benefits of wind energy; (6) examine the economics of wind power, and (7) explain some of the limits to wind power as a commercial energy source. The methods of meeting the projectmore » goals through the museum exhibit are briefly outlined in the report. Goal number three, to introduce a working wind turbine, was dropped from the final project.« less

  5. Influence of different components in a TPV PP/EPDM based with low hardness

    NASA Astrophysics Data System (ADS)

    Gheller, J.; Jacobi, M. M.

    2014-05-01

    Thermoplastic vulcanizates (TPVs) are a class of polymeric material obtained by dynamic vulcanization of an elastomer in a melted thermoplastic matrix. This work intend to evaluate different variables in the production of low hardness TPVs made of polypropylene (PP) and ethylene propylene rubber (EPDM), as well the optimization of the variables looking for TPVs with improved performance. In the Study I the influence of PP crystallinity were evaluated, in the Study II the effects of different amounts of dicumyl peroxide (DCP) were evaluated and in the Study III the amount of the phenolic resin were evaluated. This extended abstract presents, in a more detailed way, the results considering the curative phenolic resin content (Study III). The others results and discussions are briefly described in the results and discussions section. The compounds were obtained in a closed mixing chamber and their processability properties, swelling, hardness and tensile strength were evaluated. With the results obtained were possible to evaluate the influence of different ingredients in the TPVs properties. The results were discussed and presented looking for a better understanding of the influence of this variable in the final product, as well the correlation between then.

  6. Optimization of an asymmetric thin-walled tube in rotary draw bending process

    NASA Astrophysics Data System (ADS)

    Xue, Xin; Liao, Juan; Vincze, Gabriela; Gracio, Jose J.

    2013-12-01

    The rotary draw bending is one of the advanced thin-walled tube forming processes with high efficiency, low consumption and good flexibility in several industries such as automotive, aerospace and shipping. However it may cause undesirable deformations such as over-thinning and ovalization, which bring the weakening of the strength and difficulties in the assembly process respectively. Accurate modeling and effective optimization design to eliminate or reduce undesirable deformations in tube bending process have been a challenging topic. In this paper, in order to study the deformation behaviors of an asymmetric thin-walled tube in rotary draw bending process, a 3D elastic-plastic finite element model has been built under the ABAQUS environment, and the reliability of the model is validated by comparison with experiment. Then, the deformation mechanism of thin-walled tube in bending process was briefly analysis and the effects of wall thickness ratio, section height width ratio and mandrel extension on wall thinning and ovalization in bending process were investigated by using Response Surface Methodology. Finally, multi-objective optimization method was used to obtain an optimum solution of design variables based on simulation results.

  7. Room temperature ionic liquids interacting with bio-molecules: an overview of experimental and computational studies

    NASA Astrophysics Data System (ADS)

    Benedetto, Antonio; Ballone, Pietro

    2016-03-01

    We briefly review experimental and computational studies of room temperature ionic liquids (RTILs) interacting with important classes of biomolecules, including phospholipids, peptides and proteins, nucleic acids and carbohydrates. Most of these studies have been driven by the interest for RTILs applications as solvents. Thus, available experimental data cover primarily thermodynamic properties such as the reciprocal solubility of RTILs and bio-molecules, as well as phase boundaries. Less extensive data are also available on transport properties such as diffusion and viscosity of homogeneous binary (RTILs/biomolecules) and ternary (RTIL/biomolecules/water) solutions. Most of the structural information at the atomistic level, of interest especially for biochemical, pharmaceutical and nanotechnology applications, has been made available by molecular dynamics simulations. Major exceptions to this statement are represented by the results from NMR and circular dichroism spectroscopy, by selected neutron and X-ray scattering data, and by recent neutron reflectometry measurements on lipid bilayers on surfaces, hydrated by water-RTIL solutions. A final section of our paper summarizes new developments in the field of RTILs based on amino acids, that combine in themselves the two main aspects of our discussion, i.e. ionic liquids and bio-molecules.

  8. Potential release of in vivo trace metals from metallic medical implants in the human body: from ions to nanoparticles--a systematic analytical review.

    PubMed

    Matusiewicz, Henryk

    2014-06-01

    Metal ion release from metallic materials, e.g. metallic alloys and pure metals, implanted into the human body in dental and orthopedic surgery is becoming a major cause for concern. This review briefly provides an overview of both metallic alloys and pure metals used in implant materials in dental and orthopedic surgery. Additionally, a short section is dedicated to important biomaterials and their corrosive behavior in both real solutions and various types of media that model human biological fluids and tissues. The present review gives an overview of analytical methods, techniques and different approaches applied to the measurement of in vivo trace metals released into body fluids and tissues from patients carrying metal-on-metal prostheses and metal dental implants. Reference levels of ion concentrations in body fluids and tissues that have been determined by a host of studies are compiled, reviewed and presented in this paper. Finally, a collection of published clinical data on in vivo released trace metals from metallic medical implants is included. Copyright © 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

  9. The role of atomic absorption spectrometry in geochemical exploration

    USGS Publications Warehouse

    Viets, J.G.; O'Leary, R. M.

    1992-01-01

    In this paper we briefly describe the principles of atomic absorption spectrometry (AAS) and the basic hardware components necessary to make measurements of analyte concentrations. Then we discuss a variety of methods that have been developed for the introduction of analyte atoms into the light path of the spectrophotometer. This section deals with sample digestion, elimination of interferences, and optimum production of ground-state atoms, all critical considerations when choosing an AAS method. Other critical considerations are cost, speed, simplicity, precision, and applicability of the method to the wide range of materials sampled in geochemical exploration. We cannot attempt to review all of the AAS methods developed for geological materials but instead will restrict our discussion to some of those appropriate for geochemical exploration. Our background and familiarity are reflected in the methods we discuss, and we have no doubt overlooked many good methods. Our discussion should therefore be considered a starting point in finding the right method for the problem, rather than the end of the search. Finally, we discuss the future of AAS relative to other instrumental techniques and the promising new directions for AAS in geochemical exploration. ?? 1992.

  10. The functional-cognitive framework for psychological research: Controversies and resolutions.

    PubMed

    Hughes, Sean; De Houwer, Jan; Perugini, Marco

    2016-02-01

    The scientific goals, values and assumptions of functional and cognitive researchers have propelled them down two very different scientific pathways. Many have, and continue to argue, that these differences undermine any potential communication and collaboration between the two traditions. We explore a different view on this debate. Specifically, we focus on the Functional-Cognitive (FC) framework, and in particular, the idea that cognitive and functional researchers can and should interact to the benefit of both. Our article begins with a short introduction to the FC framework. We sweep aside misconceptions about the framework, present the original version as it was outlined by De Houwer (2011) and then offer our most recent thoughts on how it should be implemented. Thereafter, we reflect on its strengths and weaknesses, clarify the functional (effect-centric vs. analytic-abstractive) level and consider its many implications for cognitive research and theorising. In the final section, we briefly review the articles contained in this Special Issue. These contributions provide clear examples of the conceptual, empirical and methodological developments that can emerge when cognitive, clinical, personality and neuroscientists fully engage with the functional-cognitive perspective. © 2015 International Union of Psychological Science.

  11. The Robertsonian phenomenon in the house mouse: mutation, meiosis and speciation.

    PubMed

    Garagna, Silvia; Page, Jesus; Fernandez-Donoso, Raul; Zuccotti, Maurizio; Searle, Jeremy B

    2014-12-01

    Many different chromosomal races with reduced chromosome number due to the presence of Robertsonian fusion metacentrics have been described in western Europe and northern Africa, within the distribution area of the western house mouse Mus musculus domesticus. This subspecies of house mouse has become the ideal model for studies to elucidate the processes of chromosome mutation and fixation that lead to the formation of chromosomal races and for studies on the impact of chromosome heterozygosities on reproductive isolation and speciation. In this review, we briefly describe the history of the discovery of the first and subsequent metacentric races in house mice; then, we focus on the molecular composition of the centromeric regions involved in chromosome fusion to examine the molecular characteristics that may explain the great variability of the karyotype that house mice show. The influence that metacentrics exert on the nuclear architecture of the male meiocytes and the consequences on meiotic progression are described to illustrate the impact that chromosomal heterozygosities exert on fertility of house mice-of relevance to reproductive isolation and speciation. The evolutionary significance of the Robertsonian phenomenon in the house mouse is discussed in the final section of this review.

  12. Molecular inflammation as an underlying mechanism of the aging process and age-related diseases.

    PubMed

    Chung, H Y; Lee, E K; Choi, Y J; Kim, J M; Kim, D H; Zou, Y; Kim, C H; Lee, J; Kim, H S; Kim, N D; Jung, J H; Yu, B P

    2011-07-01

    Aging is a biological process characterized by time-dependent functional declines that are influenced by changes in redox status and by oxidative stress-induced inflammatory reactions. An organism's pro-inflammatory status may underlie the aging process and age-related diseases. In this review, we explore the molecular basis of low-grade, unresolved, subclinical inflammation as a major risk factor for exacerbating the aging process and age-related diseases. We focus on the redox-sensitive transcription factors, NF-κB and FOXO, which play essential roles in the expression of pro-inflammatory mediators and anti-oxidant enzymes, respectively. Major players in molecular inflammation are discussed with respect to the age-related up-regulation of pro-inflammatory cytokines and adhesion molecules, cyclo-oxygenase-2, lipoxygenase, and inducible nitric oxide synthase. The molecular inflammation hypothesis proposed by our laboratory is briefly described to give further molecular insights into the intricate interplay among redox balance, pro-inflammatory gene activation, and chronic age-related inflammatory diseases. The final section discusses calorie restriction as an aging-retarding intervention that also exhibits extraordinarily effective anti-inflammatory activity by modulating GSH redox, NF-κB, SIRT1, PPARs, and FOXOs.

  13. Game theory and plant ecology.

    PubMed

    McNickle, Gordon G; Dybzinski, Ray

    2013-04-01

    The fixed and plastic traits possessed by a plant, which may be collectively thought of as its strategy, are commonly modelled as density-independent adaptations to its environment. However, plant strategies may also represent density- or frequency-dependent adaptations to the strategies used by neighbours. Game theory provides the tools to characterise such density- and frequency-dependent interactions. Here, we review the contributions of game theory to plant ecology. After briefly reviewing game theory from the perspective of plant ecology, we divide our review into three sections. First, game theoretical models of allocation to shoots and roots often predict investment in those organs beyond what would be optimal in the absence of competition. Second, game theoretical models of enemy defence suggest that an individual's investment in defence is not only a means of reducing its own tissue damage but also a means of deflecting enemies onto competitors. Finally, game theoretical models of trade with mutualistic partners suggest that the optimal trade may reflect competition for access to mutualistic partners among plants. In short, our review provides an accessible entrance to game theory that will help plant ecologists enrich their research with its worldview and existing predictions. © 2013 Blackwell Publishing Ltd/CNRS.

  14. A Primer on Metagenomics

    PubMed Central

    Wooley, John C.; Godzik, Adam; Friedberg, Iddo

    2010-01-01

    Metagenomics is a discipline that enables the genomic study of uncultured microorganisms. Faster, cheaper sequencing technologies and the ability to sequence uncultured microbes sampled directly from their habitats are expanding and transforming our view of the microbial world. Distilling meaningful information from the millions of new genomic sequences presents a serious challenge to bioinformaticians. In cultured microbes, the genomic data come from a single clone, making sequence assembly and annotation tractable. In metagenomics, the data come from heterogeneous microbial communities, sometimes containing more than 10,000 species, with the sequence data being noisy and partial. From sampling, to assembly, to gene calling and function prediction, bioinformatics faces new demands in interpreting voluminous, noisy, and often partial sequence data. Although metagenomics is a relative newcomer to science, the past few years have seen an explosion in computational methods applied to metagenomic-based research. It is therefore not within the scope of this article to provide an exhaustive review. Rather, we provide here a concise yet comprehensive introduction to the current computational requirements presented by metagenomics, and review the recent progress made. We also note whether there is software that implements any of the methods presented here, and briefly review its utility. Nevertheless, it would be useful if readers of this article would avail themselves of the comment section provided by this journal, and relate their own experiences. Finally, the last section of this article provides a few representative studies illustrating different facets of recent scientific discoveries made using metagenomics. PMID:20195499

  15. Aeronautic Instruments. Section II : Altitude Instruments

    NASA Technical Reports Server (NTRS)

    Mears, A H; Henrickson, H B; Brombacher, W G

    1923-01-01

    This report is Section two of a series of reports on aeronautic instruments (Technical Report nos. 125 to 132, inclusive). This section discusses briefly barometric altitude determinations, and describes in detail the principal types of altimeters and barographs used in aeronautics during the recent war. This is followed by a discussion of performance requirements for such instruments and an account of the methods of testing developed by the Bureau of Standards. The report concludes with a brief account of the results of recent investigations. For accurate measurements of altitude, reference must also be made to thermometer readings of atmospheric temperature, since the altitude is not fixed by atmospheric pressure alone. This matter is discussed in connection with barometric altitude determination.

  16. Research progress about chemical energy storage of solar energy

    NASA Astrophysics Data System (ADS)

    Wu, Haifeng; Xie, Gengxin; Jie, Zheng; Hui, Xiong; Yang, Duan; Du, Chaojun

    2018-01-01

    In recent years, the application of solar energy has been shown obvious advantages. Solar energy is being discontinuity and inhomogeneity, so energy storage technology becomes the key to the popularization and utilization of solar energy. Chemical storage is the most efficient way to store and transport solar energy. In the first and the second section of this paper, we discuss two aspects about the solar energy collector / reactor, and solar energy storage technology by hydrogen production, respectively. The third section describes the basic application of solar energy storage system, and proposes an association system by combining solar energy storage and power equipment. The fourth section briefly describes several research directions which need to be strengthened.

  17. Mental workload in decision and control

    NASA Technical Reports Server (NTRS)

    Sheridan, T. B.

    1979-01-01

    This paper briefly reviews the problems of defining and measuring the 'mental workload' of aircraft pilots and other human operators of complex dynamic systems. Of the alternative approaches the author indicates a clear preference for the use of subjective scaling. Some recent experiments from MIT and elsewhere are described which utilize subjective mental workload scales in conjunction with human decision and control tasks in the laboratory. Finally a new three-dimensional mental workload rating scale, under current development for use by IFR aircraft pilots, is presented.

  18. The Mars Science Laboratory Entry, Descent, and Landing Flight Software

    NASA Technical Reports Server (NTRS)

    Gostelow, Kim P.

    2013-01-01

    This paper describes the design, development, and testing of the EDL program from the perspective of the software engineer. We briefly cover the overall MSL flight software organization, and then the organization of EDL itself. We discuss the timeline, the structure of the GNC code (but not the algorithms as they are covered elsewhere in this conference) and the command and telemetry interfaces. Finally, we cover testing and the influence that testability had on the EDL flight software design.

  19. Radiation effects in astrophysical ices

    NASA Astrophysics Data System (ADS)

    Boduch, Philippe; Dartois, Emmanuel; de Barros, Ana L. F.; da Silveira, Enio F.; Domaracka, Alicja; Lv, Xue-Yang; Palumbo, Maria Elisabetta; Pilling, Sergio; Rothard, Hermann; Seperuelo Duarte, Eduardo; Strazzulla, Giovanni

    2015-07-01

    The interaction of heavy ions with astrophysical ices was studied at different beamlines of GANIL by infrared absorption spectroscopy. This allowed simulating in the laboratory the physico-chemical modifications induced in icy objects in space, exposed to radiation fields such as the solar wind, magnetospheric particles and interstellar cosmic rays. We briefly discuss sputtering, destruction and formation of molecules, amorphization and compaction, implantation, and finally the formation of organic molecules. This latter topic is related to the question of the initial conditions for the emergence of life.

  20. Reconstruction of SAXS Profiles from Protein Structures

    PubMed Central

    Putnam, Daniel K.; Lowe, Edward W.

    2013-01-01

    Small angle X-ray scattering (SAXS) is used for low resolution structural characterization of proteins often in combination with other experimental techniques. After briefly reviewing the theory of SAXS we discuss computational methods based on 1) the Debye equation and 2) Spherical Harmonics to compute intensity profiles from a particular macromolecular structure. Further, we review how these formulas are parameterized for solvent density and hydration shell adjustment. Finally we introduce our solution to compute SAXS profiles utilizing GPU acceleration. PMID:24688746

  1. Macromolecular therapeutics.

    PubMed

    Yang, Jiyuan; Kopeček, Jindřich

    2014-09-28

    This review covers water-soluble polymer-drug conjugates and macromolecules that possess biological activity without attached low molecular weight drugs. The main design principles of traditional and backbone degradable polymer-drug conjugates as well as the development of a new paradigm in nanomedicines - (low molecular weight) drug-free macromolecular therapeutics are discussed. To address the biological features of cancer, macromolecular therapeutics directed to stem/progenitor cells and the tumor microenvironment are deliberated. Finally, the future perspectives of the field are briefly debated. Copyright © 2014 Elsevier B.V. All rights reserved.

  2. Review of betavoltaic energy conversion

    NASA Astrophysics Data System (ADS)

    Olsen, Larry C.

    1993-05-01

    Betavoltaic energy conversion refers to the generation of power by coupling a beta source to a semiconductor junction device. The theory of betavoltaic energy conversion and some past studies of the subject are briefly reviewed. Calculations of limiting efficiencies for semiconductor cells versus bandgap are presented along with specific studies for Pm-147 and Ni-63 fueled devices. The approach used for fabricating Pm-147 fueled batteries by the author in the early 1970's is reviewed. Finally, the potential performance of advanced betavoltaic power sources is considered.

  3. Legal implications of monitoring workers for carcinogenic and mutagenic risk.

    PubMed

    Damme, C J

    1982-01-01

    Many industries have initiated testing programs designed to identify workers who are especially vulnerable to workplace assaults by carcinogenic or mutagenic agents. This paper examines a number of legal issues attendant on such programs, including disclosure and consent, confidentiality, and other potential liability-producing factors. This paper also briefly looks at the legal issues that might arise if the federal government were to mandate similar programs. Finally, the basic rationale of industrial monitoring programs is discussed within the context of the emerging legal issues.

  4. Advances in the Theory of Complex Networks

    NASA Astrophysics Data System (ADS)

    Peruani, Fernando

    An exhaustive and comprehensive review on the theory of complex networks would imply nowadays a titanic task, and it would result in a lengthy work containing plenty of technical details of arguable relevance. Instead, this chapter addresses very briefly the ABC of complex network theory, visiting only the hallmarks of the theoretical founding, to finally focus on two of the most interesting and promising current research problems: the study of dynamical processes on transportation networks and the identification of communities in complex networks.

  5. The Power of a Question: A Case Study of Two Organizational Knowledge Capture Systems

    NASA Technical Reports Server (NTRS)

    Cooper, Lynn P.

    2003-01-01

    This document represents a presentation regarding organizational knowledge capture systems which was delivered at the HICSS-36 conference held from January 6-9, 2003. An exploratory case study of two knowledge resources is offered. Then, two organizational knowledge capture systems are briefly described: knowledge transfer from practitioner and the use of questions to represent knowledge. Finally, the creation of a database of peer review questions is suggested as a method of promoting organizational discussions and knowledge representation and exchange.

  6. Review of betavoltaic energy conversion

    NASA Technical Reports Server (NTRS)

    Olsen, Larry C.

    1993-01-01

    Betavoltaic energy conversion refers to the generation of power by coupling a beta source to a semiconductor junction device. The theory of betavoltaic energy conversion and some past studies of the subject are briefly reviewed. Calculations of limiting efficiencies for semiconductor cells versus bandgap are presented along with specific studies for Pm-147 and Ni-63 fueled devices. The approach used for fabricating Pm-147 fueled batteries by the author in the early 1970's is reviewed. Finally, the potential performance of advanced betavoltaic power sources is considered.

  7. Five-dimensional collective Hamiltonian with the Gogny force: An ongoing saga

    NASA Astrophysics Data System (ADS)

    Libert, J.; Delaroche, J.-P.; Girod, M.

    2016-07-01

    We provide a sample of analyses for nuclear spectroscopic properties based on the five-dimensional collective Hamiltonian (5DCH) implemented with the Gogny force. The very first illustration is dating back to the late 70's. It is next followed by others, focusing on shape coexistence, shape isomerism, superdeformation, and systematics over the periodic table. Finally, the inclusion of Thouless-Valatin dynamical contributions to vibrational mass parameters is briefly discussed as a mean of strengthening the basis of the 5DCH theory.

  8. Mass spectrometry in systems biology an introduction.

    PubMed

    Dunn, Warwick B

    2011-01-01

    The qualitative detection, quantification, and structural characterization of analytes in biological systems are important requirements for objectives to be fulfilled in systems biology research. One analytical tool applied to a multitude of systems biology studies is mass spectrometry, particularly for the study of proteins and metabolites. Here, the role of mass spectrometry in systems biology will be assessed, the advantages and disadvantages discussed, and the instrument configurations available described. Finally, general applications will be briefly reviewed. Copyright © 2011 Elsevier Inc. All rights reserved.

  9. Stereo vision and strabismus

    PubMed Central

    Read, J C A

    2015-01-01

    Binocular stereopsis, or stereo vision, is the ability to derive information about how far away objects are, based solely on the relative positions of the object in the two eyes. It depends on both sensory and motor abilities. In this review, I briefly outline some of the neuronal mechanisms supporting stereo vision, and discuss how these are disrupted in strabismus. I explain, in some detail, current methods of assessing stereo vision and their pros and cons. Finally, I review the evidence supporting the clinical importance of such measurements. PMID:25475234

  10. Applications of lasers to production metrology, control, and machine 'Vision'

    NASA Astrophysics Data System (ADS)

    Pryor, T. R.; Erf, R. K.; Gara, A. D.

    1982-06-01

    General areas of laser application to production measurement and inspection are reviewed together with the associated laser measurement techniques. The topics discussed include dimensional gauging of part profiles using laser imaging or scanning techniques, laser triangulation for surface contour measurement, surface finish measurement and defect inspection, holography and speckle techniques, and strain measurement. The emerging field of robot guidance utilizing lasers and other sensing means is examined, and, finally, the use of laser marking and reading equipment is briefly discussed.

  11. Final Report for DOE Grant DE-FG02-06ER64160 Retrieval of Cloud Properties and Direct Testing of Cloud and Radiation Parameterizations using ARM Observations.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Donovan, David Patrick

    This report briefly summaries the work performed at KNMI under DOE Grant DE-FG02-06ER64160 which, in turn was conducted in support of DOE Grant DE-FG02-90ER61071 lead by E. Clothieux of Penn. State U. The specific work at KNMI revolved around the development and application of the EarthCARE simulator to ground-based multi-sensor simulations.

  12. The Grain Structure of Castings: Some Aspects of Modelling

    NASA Technical Reports Server (NTRS)

    Hellawell, A.

    1995-01-01

    The efficacy of the modelling of the solidification of castings is typically tested against observed cooling curves and the final grain structures and sizes. Without thermo solutal convection, equiaxed grain formation is promoted by introduction of heterogeneous substrates into the melt, as grain refiners. With efficient thermo solutal convection, dendrite fragments from the mushy zone can act as an intrinsic source of equiaxed grains and resort to grain refining additions is unnecessary. The mechanisms of dendrite fragmentation and transport of these fragments are briefly considered.

  13. Collisional plateaus. [in earth and Venus lithospheres

    NASA Technical Reports Server (NTRS)

    Morgan, P.; Burke, K.

    1985-01-01

    Aspects of the geology of collisional plateaus formed by the thickening of continental crust are briefly reviewed. The history of studies of collisional plateaus is summarized, and igneous activity in collisional plateaus is discussed. Isostatic considerations pertaining to these plateaus are addressed, developing models of isostatic support of topography which illustrate the importance of compressional tectonics in the creation of high altitude plateaus. Possible analogous environments on Venus are considered. Finally, the paradox of extension associated with compression in the plateaus is discussed.

  14. The onset of shear modes in the high frequency spectrum of simple disordered systems: Current knowledge and perspectives

    DOE PAGES

    Cunsolo, Alessandro; Suvorov, Alexey; Cai, Yong Q.

    2015-10-20

    In this study, nearly two decades of thorough Inelastic X Ray Scattering (IXS) studies of transverse-like excitation in the spectrum simple amorphous materials are reviewed. A particular attention is given to the case of liquid water and other prototypical samples, through a discussion of both solved and still open issues. Finally, the perspectives opened up by the development of next generation IXS instruments with unprecedented contrast and resolution bandwidth are briefly illustrated.

  15. Visualising Astronomy: Invisible - Impacts and Rings better

    NASA Astrophysics Data System (ADS)

    Wyatt, R.

    2009-11-01

    Stories about unpleasant experiences when collaborating with journalists circulate among many scientists. Some of them regard journalists as potential enemies against whom they have to be prepared. But is the idea that a journalist must be either friend or foe appropriate at all? This article briefly examines the changing relationship between astronomers, science journalists and the general public over the last few decades. It then gives a view from inside science journalism and finally suggests some ideas on how to establish a better relationship between scientists and journalists.

  16. Confluence of climate change policies and international trade

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Vickery, R.E. Jr.

    1997-12-31

    The paper summarizes market information on energy conservation and renewable energy industries in the U.S., and highlights activities of the International Trade Administration. International treaties agreements on environmental issues are examined with respect to their influence on U.S. trade promotion and job creation. A sectoral analysis of the economic impact of greenhouse gas emissions reductions on industries is very briefly summarized. Finally, the need for a climate change treaty in spite of possible adverse impacts is discussed. 1 tab.

  17. Acoustic Modeling of Lightweight Structures: A Literature Review

    NASA Astrophysics Data System (ADS)

    Yang, Shasha; Shen, Cheng

    2017-10-01

    This paper gives an overview of acoustic modeling for three kinds of typical lightweight structures including double-leaf plate system, stiffened single (or double) plate and porous material. Classical models are citied to provide frame work of theoretical modeling for acoustic property of lightweight structures; important research advances derived by our research group and other authors are introduced to describe the current state of art for acoustic research. Finally, remaining problems and future research directions are concluded and prospected briefly

  18. Near-infrared scintillation of liquid argon

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Alexander, T.; Escobar, C. O.; Lippincott, W. H.

    2016-03-03

    Since the 1970s it has been known that noble gases scintillate in the near infrared (NIR) region of the spectrum (0.7more » $$\\mu$$m < $$\\lambda$$; < 1.5$$\\mu$$m). More controversial has been the question of the NIR light yield for condensed noble gases. We first present the motivation for using the NIR scintillation in liquid argon detectors, then briefly review early as well as more recent efforts and finally show encouraging preliminary results of a test performed at Fermilab.« less

  19. Wide sector coverage antennas

    NASA Astrophysics Data System (ADS)

    Yaw, D. F.

    1984-09-01

    The general design and performance characteristics of transmit and receive antennas that are currently used in electronic warfare systems are reviewed. Among transmit antennas, three-to-one bandwidth, asymmetric-beam, and circularly polarized horns are discussed, as are extremely broadband monopoles and spiral antennas. In a discussion of receive antennas, attention is given to flat and conical spirals, including cavity-backed flat spirals operating over the 2.5-18 GHz range; log periodic dipoles; and biconical horns. Finally, the design configurations and performance of interferometer direction-finding systems are briefly discussed.

  20. Environmental Impact Analysis Process. Final Environmental Impact Statement for Expansion of the Melrose Air Force Range, Curry and Roosevelt Counties, New Mexico

    DTIC Science & Technology

    1985-04-18

    discuss very briefly the logic, or substance, of the issues in this possible decision--why it might not be logical. And, third, the moral , or ethical...o’f the issue - authors advocating measurable effect and those indicating no effect. 38 CHABA has taken the position that current evidence is suggestive...but it does not provide definitive answers on the long-term health effect issue . CHABA encourages more definitive research with adequate controls

  1. [Animal protection without limits? Human-animal relations in between anthropomorphism and objectification].

    PubMed

    Grimm, Herwig; Hartnack, Sonja

    2013-01-01

    In view of recent developments in human-animal relations, vets and ethicists face a new problem: On the one hand, animals such as mammals and birds are used extensively and are in danger to be reduced to mere production units e. g. in the agricultural production, measuring devices in laboratories, sports equipment etc. On the other hand, biologically similar animals are perceived as family members or partners and are almost treated like humans. The article summarizes the results of a workshop that dealt with reductionism and anthropomorphism in human-animal relations. Vets and ethicists tackled the question how the unequal treatment of biologically similar animals can be better understood and whether it can be ethically justified. In the first section, the problem of inconsistency in human-animals relations is briefly sketched. The second part of the article addresses the ethics of unequal treatment of similar animals in different contexts. The following section inquires possible solutions and the advantages and disadvantages of biological criteria versus social criteria in animal protection. Finally, the background and reasons for our moral intuitions of injustice associated with the inconsistencies in human-animal relations are outlined. This fourth section refers to the presentation of Peter Kunzmann during the workshop on the unequal treatment of equals.The article closes with some general remarks on the issue. One main result of the workshop can be stated as follows: Due to the fact that the various human-animal relations gain their ethical justification from different ethical reasons, the unequal treatment of similar animals in different contexts is not ethically wrong per se. However, every intrusive dealing or interaction with animals is in itself in need of ethical justification.

  2. A Ranking Analysis/An Interlinking Approach of New Triangular Fuzzy Cognitive Maps and Combined Effective Time Dependent Matrix

    NASA Astrophysics Data System (ADS)

    Adiga, Shreemathi; Saraswathi, A.; Praveen Prakash, A.

    2018-04-01

    This paper aims an interlinking approach of new Triangular Fuzzy Cognitive Maps (TrFCM) and Combined Effective Time Dependent (CETD) matrix to find the ranking of the problems of Transgenders. Section one begins with an introduction that briefly describes the scope of Triangular Fuzzy Cognitive Maps (TrFCM) and CETD Matrix. Section two provides the process of causes of problems faced by Transgenders using Fuzzy Triangular Fuzzy Cognitive Maps (TrFCM) method and performs the calculations using the collected data among the Transgender. In Section 3, the reasons for the main causes for the problems of the Transgenders. Section 4 describes the Charles Spearmans coefficients of rank correlation method by interlinking of Triangular Fuzzy Cognitive Maps (TrFCM) Method and CETD Matrix. Section 5 shows the results based on our study.

  3. Processor-In-Memory (PIM) Based Architectures for PetaFlops Potential Massively Parallel Processing

    NASA Technical Reports Server (NTRS)

    Kogge, Peter M.

    1996-01-01

    The report summarizes the work performed at the University of Notre Dame under a NASA grant from July 15, 1995 through July 14, 1996. Researchers involved in the work included the PI, Dr. Peter M. Kogge, and three graduate students under his direction in the Computer Science and Engineering Department: Stephen Dartt, Costin Iancu, and Lakshmi Narayanaswany. The organization of this report is as follows. Section 2 is a summary of the problem addressed by this work. Section 3 is a summary of the project's objectives and approach. Section 4 summarizes PIM technology briefly. Section 5 overviews the main results of the work. Section 6 then discusses the importance of the results and future directions. Also attached to this report are copies of several technical reports and publications whose contents directly reflect results developed during this study.

  4. User's manual for three dimensional FDTD version C code for scattering from frequency-independent dielectric and magnetic materials

    NASA Technical Reports Server (NTRS)

    Beggs, John H.; Luebbers, Raymond J.; Kunz, Karl S.

    1991-01-01

    The Penn State Finite Difference Time Domain Electromagnetic Scattering Code Version C is a three dimensional numerical electromagnetic scattering code based upon the Finite Difference Time Domain Technique (FDTD). The supplied version of the code is one version of our current three dimensional FDTD code set. This manual provides a description of the code and corresponding results for several scattering problems. The manual is organized into fourteen sections: introduction, description of the FDTD method, operation, resource requirements, Version C code capabilities, a brief description of the default scattering geometry, a brief description of each subroutine, a description of the include file (COMMONC.FOR), a section briefly discussing Radar Cross Section (RCS) computations, a section discussing some scattering results, a sample problem setup section, a new problem checklist, references and figure titles.

  5. User's manual for three dimensional FDTD version D code for scattering from frequency-dependent dielectric and magnetic materials

    NASA Technical Reports Server (NTRS)

    Beggs, John H.; Luebbers, Raymond J.; Kunz, Karl S.

    1991-01-01

    The Penn State Finite Difference Time Domain Electromagnetic Scattering Code Version D is a three dimensional numerical electromagnetic scattering code based upon the Finite Difference Time Domain Technique (FDTD). The supplied version of the code is one version of our current three dimensional FDTD code set. This manual provides a description of the code and corresponding results for several scattering problems. The manual is organized into fourteen sections: introduction, description of the FDTD method, operation, resource requirements, Version D code capabilities, a brief description of the default scattering geometry, a brief description of each subroutine, a description of the include file (COMMOND.FOR), a section briefly discussing Radar Cross Section (RCS) computations, a section discussing some scattering results, a sample problem setup section, a new problem checklist, references and figure titles.

  6. User's manual for three dimensional FDTD version A code for scattering from frequency-independent dielectric materials

    NASA Technical Reports Server (NTRS)

    Beggs, John H.; Luebbers, Raymond J.; Kunz, Karl S.

    1992-01-01

    The Penn State Finite Difference Time Domain (FDTD) Electromagnetic Scattering Code Version A is a three dimensional numerical electromagnetic scattering code based on the Finite Difference Time Domain technique. The supplied version of the code is one version of our current three dimensional FDTD code set. The manual provides a description of the code and the corresponding results for the default scattering problem. The manual is organized into 14 sections: introduction, description of the FDTD method, operation, resource requirements, Version A code capabilities, a brief description of the default scattering geometry, a brief description of each subroutine, a description of the include file (COMMONA.FOR), a section briefly discussing radar cross section (RCS) computations, a section discussing the scattering results, a sample problem setup section, a new problem checklist, references, and figure titles.

  7. User's manual for three dimensional FDTD version B code for scattering from frequency-dependent dielectric materials

    NASA Technical Reports Server (NTRS)

    Beggs, John H.; Luebbers, Raymond J.; Kunz, Karl S.

    1991-01-01

    The Penn State Finite Difference Time Domain Electromagnetic Scattering Code Version B is a three dimensional numerical electromagnetic scattering code based upon the Finite Difference Time Domain Technique (FDTD). The supplied version of the code is one version of our current three dimensional FDTD code set. This manual provides a description of the code and corresponding results for several scattering problems. The manual is organized into fourteen sections: introduction, description of the FDTD method, operation, resource requirements, Version B code capabilities, a brief description of the default scattering geometry, a brief description of each subroutine, a description of the include file (COMMONB.FOR), a section briefly discussing Radar Cross Section (RCS) computations, a section discussing some scattering results, a sample problem setup section, a new problem checklist, references and figure titles.

  8. Thermophysical properties of simple liquid metals: A brief review of theory

    NASA Technical Reports Server (NTRS)

    Stroud, David

    1993-01-01

    In this paper, we review the current theory of the thermophysical properties of simple liquid metals. The emphasis is on thermodynamic properties, but we also briefly discuss the nonequilibrium properties of liquid metals. We begin by defining a 'simple liquid metal' as one in which the valence electrons interact only weakly with the ionic cores, so that the interaction can be treated by perturbation theory. We then write down the equilibrium Hamiltonian of a liquid metal as a sum of five terms: the bare ion-ion interaction, the electron-electron interaction, the bare electron-ion interaction, and the kinetic energies of electrons and ions. Since the electron-ion interaction can be treated by perturbation, the electronic part contributes in two ways to the Helmholtz free energy: it gives a density-dependent term which is independent of the arrangement of ions, and it acts to screen the ion-ion interaction, giving rise to effective ion-ion pair potentials which are density-dependent, in general. After sketching the form of a typical pair potential, we briefly enumerate some methods for calculating the ionic distribution function and hence the Helmholtz free energy of the liquid: monte Carlo simulations, molecular dynamics simulations, and thermodynamic perturbation theory. The final result is a general expression for the Helmholtz free energy of the liquid metal. It can be used to calculate a wide range of thermodynamic properties of simple metal liquids, which we enumerate. They include not only a range of thermodynamic coefficients of both metals and alloys, but also many aspects of the phase diagram, including freezing curves of pure elements and phase diagrams of liquid alloys (including liquidus and solidus curves). We briefly mention some key discoveries resulting from previous applications of this method, and point out that the same methods work for other materials not normally considered to be liquid metals (such as colloidal suspensions, in which the suspended microspheres behave like ions screened by the salt solution in which they are suspended). We conclude with a brief discussion of some non-equilibrium (i.e., transport) properties which can be treated by an extension of these methods. These include electrical resistivity, thermal conductivity, viscosity, atomic self-diffusion coefficients, concentration diffusion coefficients in alloys, surface tension and thermal emissivity. Finally, we briefly mention two methods by which the theory might be extended to non-simple liquid metals: these are empirical techniques (i.e., empirical two- and three-body potentials), and numerical many-body approaches. Both may be potentially applicable to extremely complex systems, such as nonstoichiometric liquid semiconductor alloys.

  9. Nuclear Matrix Proteins in Disparity of Prostate Cancer

    DTIC Science & Technology

    2013-09-01

    nuclear coactivator-3 (NCOA3). 5 Methods Patients and Prostate Cancer Specimens Fresh, flash -frozen specimens were obtained from age- (50 to...for reliable data interpretation. Gene Array Analysis Total RNA isolated from LCM-procured normal epithelium and tumor cells from flash -frozen...PCR Briefly, RNA was extracted from matched LCM procured normal epithelium and tumor cells of age-, tumor grade-matched flash -frozen sections (n=24

  10. Development of a Conservative Model Validation Approach for Reliable Analysis

    DTIC Science & Technology

    2015-01-01

    CIE 2015 August 2-5, 2015, Boston, Massachusetts, USA [DRAFT] DETC2015-46982 DEVELOPMENT OF A CONSERVATIVE MODEL VALIDATION APPROACH FOR RELIABLE...obtain a conservative simulation model for reliable design even with limited experimental data. Very little research has taken into account the...3, the proposed conservative model validation is briefly compared to the conventional model validation approach. Section 4 describes how to account

  11. IonRayTrace: An HF Propagation Model for Communications and Radar Applications

    DTIC Science & Technology

    2014-12-01

    for modeling the impact of ionosphere variability on detection algorithms. Modification of IonRayTrace’s source code to include flexible gridding and...color denotes plasma frequency in MHz .................................................................. 6 4. Ionospheric absorption (dB) versus... Ionosphere for its environmental background [3]. IonRayTrace’s operation is summarized briefly in Section 3. However, the scope of this document is primarily

  12. Engineer Modeling Study. Volume II. Users Manual.

    DTIC Science & Technology

    1982-09-01

    Distribution Center, Digital Equip- ment Corporation, 1980). The following paragraphs briefly describe each of the major input sections...abbreviation 3. A sequence number for post-processing 4. Clock time 5. Order number pointer (six digits ) 6. Job number pointer (six digits ) 7. Unit number...KIT) Users Manual (Boeing Computer % Services, Inc., 1977). S VAX/VMS Users Manual. Volume 3A (Software Distribution Center, Digital Equipment

  13. Femtosecond Amplifiers and Microlasers in the Deep Ultraviolet

    DTIC Science & Technology

    2013-11-19

    Laser guide stars have applications of growing importance to the DOD, astronomy, and environmental monitoring. However, realizing a laser that is...pump wavelength, photoassociation-pumped lasers hold considerable promise as guide star lasers . The most exciting aspect of these results, however...highlights of several experiments that were mentioned briefly in the last section. A. Dual Wavelength Sodium Laser Pumped By Na-Xe Pair Absorption

  14. Switching Sides: Coalition Warfare in Recent Afghan History

    DTIC Science & Technology

    2010-04-01

    model are Power-Distance, Individualism, Masculinity , and Uncertainty Avoidance. For brevity’s sake, this paper will only briefly describe Hofstede’s...through the period of Soviet occupation. The Army defection rate was about 10,000 soldiers per year. 28 Incompatible ideological or religious...their foreign partners – with different cultures and ideological beliefs – seem less inclined to do so. Previous sections of this paper provide

  15. 18 CFR 250.6 - Form of application to be filed by distributor under section 7(a), seeking gas service of not...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., commercial and industrial customers for each of the first three years of proposed operations (Mcf at 14.73..., commercial and industrial customers for each of the first three years of proposed operations (Mcf at 14.73... lines, legal fees, financing fees and engineering fees, and briefly state how the estimates were derived...

  16. 18 CFR 250.6 - Form of application to be filed by distributor under section 7(a), seeking gas service of not...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., commercial and industrial customers for each of the first three years of proposed operations (Mcf at 14.73..., commercial and industrial customers for each of the first three years of proposed operations (Mcf at 14.73... lines, legal fees, financing fees and engineering fees, and briefly state how the estimates were derived...

  17. 18 CFR 250.6 - Form of application to be filed by distributor under section 7(a), seeking gas service of not...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., commercial and industrial customers for each of the first three years of proposed operations (Mcf at 14.73..., commercial and industrial customers for each of the first three years of proposed operations (Mcf at 14.73... lines, legal fees, financing fees and engineering fees, and briefly state how the estimates were derived...

  18. 18 CFR 250.6 - Form of application to be filed by distributor under section 7(a), seeking gas service of not...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., commercial and industrial customers for each of the first three years of proposed operations (Mcf at 14.73..., commercial and industrial customers for each of the first three years of proposed operations (Mcf at 14.73... lines, legal fees, financing fees and engineering fees, and briefly state how the estimates were derived...

  19. 18 CFR 250.6 - Form of application to be filed by distributor under section 7(a), seeking gas service of not...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., commercial and industrial customers for each of the first three years of proposed operations (Mcf at 14.73..., commercial and industrial customers for each of the first three years of proposed operations (Mcf at 14.73... lines, legal fees, financing fees and engineering fees, and briefly state how the estimates were derived...

  20. Nursing Education in High Blood Pressure Control. Report of the Task Force on the Role of Nursing in High Blood Pressure Control.

    ERIC Educational Resources Information Center

    National Institutes of Health (DHEW), Bethesda, MD. High Blood Pressure Information Center.

    This curriculum guide on high blood pressure (hypertension) for nursing educators has five sections: (1) Introduction and Objectives provides information regarding the establishment and objectives of the National Task Force on the Role of Nursing in High Blood Pressure Control and briefly discusses nursing's role in hypertension control; (2) Goals…

  1. Computer Aided Design in FE. Some Suggestions on the Inclusion of CAD Topics in Mechanical Engineering Courses. An Occasional Paper.

    ERIC Educational Resources Information Center

    Ingham, P. C.

    This report investigates the feasibility of including computer aided design (CAD) materials in engineering courses. Section 1 briefly discusses the inevitability of CAD being adopted widely by British industry and the consequent need for its inclusion in engineering syllabi at all levels. A short description of what is meant by CAD follows in…

  2. 78 FR 57685 - Guidance Regarding Deduction and Capitalization of Expenditures Related to Tangible Property

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-19

    ...This document contains final regulations that provide guidance on the application of sections 162(a) and 263(a) of the Internal Revenue Code (Code) to amounts paid to acquire, produce, or improve tangible property. The final regulations clarify and expand the standards in the current regulations under sections 162(a) and 263(a). These final regulations replace and remove temporary regulations under sections 162(a) and 263(a) and withdraw proposed regulations that cross referenced the text of those temporary regulations. This document also contains final regulations under section 167 regarding accounting for and retirement of depreciable property and final regulations under section 168 regarding accounting for property under the Modified Accelerated Cost Recovery System (MACRS) other than general asset accounts. The final regulations will affect all taxpayers that acquire, produce, or improve tangible property. These final regulations do not finalize or remove the 2011 temporary regulations under section 168 regarding general asset accounts and disposition of property subject to section 168, which are addressed in the notice of proposed rulemaking on this subject in the Proposed Rules section in this issue of the Federal Register.

  3. Uncertainty Quantification of Hypothesis Testing for the Integrated Knowledge Engine

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cuellar, Leticia

    2012-05-31

    The Integrated Knowledge Engine (IKE) is a tool of Bayesian analysis, based on Bayesian Belief Networks or Bayesian networks for short. A Bayesian network is a graphical model (directed acyclic graph) that allows representing the probabilistic structure of many variables assuming a localized type of dependency called the Markov property. The Markov property in this instance makes any node or random variable to be independent of any non-descendant node given information about its parent. A direct consequence of this property is that it is relatively easy to incorporate new evidence and derive the appropriate consequences, which in general is notmore » an easy or feasible task. Typically we use Bayesian networks as predictive models for a small subset of the variables, either the leave nodes or the root nodes. In IKE, since most applications deal with diagnostics, we are interested in predicting the likelihood of the root nodes given new observations on any of the children nodes. The root nodes represent the various possible outcomes of the analysis, and an important problem is to determine when we have gathered enough evidence to lean toward one of these particular outcomes. This document presents criteria to decide when the evidence gathered is sufficient to draw a particular conclusion or decide in favor of a particular outcome by quantifying the uncertainty in the conclusions that are drawn from the data. The material in this document is organized as follows: Section 2 presents briefly a forensics Bayesian network, and we explore evaluating the information provided by new evidence by looking first at the posterior distribution of the nodes of interest, and then at the corresponding posterior odds ratios. Section 3 presents a third alternative: Bayes Factors. In section 4 we finalize by showing the relation between the posterior odds ratios and Bayes factors and showing examples these cases, and in section 5 we conclude by providing clear guidelines of how to use these for the type of Bayesian networks used in IKE.« less

  4. Item Response Theory. Research Report. ETS RR-13-28. ETS R&D Scientific and Policy Contributions Series. ETS SPC-13-05

    ERIC Educational Resources Information Center

    Carlson, James E.; von Davier, Matthias

    2013-01-01

    Few would doubt that ETS researchers have contributed more to the general topic of item response theory (IRT) than individuals from any other institution. In this report, we briefly review most of those contributions, dividing them into sections by decades of publication, beginning with early work by Fred Lord and Bert Green in the 1950s and…

  5. Wet countdown demonstration and flight readiness firing

    NASA Technical Reports Server (NTRS)

    1981-01-01

    The prelaunch tests for the Space Transportation System 1 flight are briefly described. Testing is divided into two major sections: the wet countdown demonstration test/flight readiness firing, which includes a 20 second test firing of the orbiter's three main engines, and a mission verification test, which is centered on flight and landing operations. The functions of the countdown sequence are listed and end of mission and mission abort exercises are described.

  6. Liberalisation, gender, and the land question in sub-Saharan Africa.

    PubMed

    Izumi, K

    1999-11-01

    This article focuses on land reform initiatives undertaken in sub-Saharan African countries since the late 1980s. Section 1 sheds light on the changes in land tenure during the economic liberalization of the region. Section 2 briefly examines the gender-blind "mainstream" theoretical debates on land, and gender-sensitive studies on land issues. Section 3 offers insights on land issues in Africa from a gender perspective. Sections 4 and 5 reviewed the cases of Tanzania and Zimbabwe who have undergone a radical transition in terms of institutional land reforms since the 1980s, and the impact of economic and political liberalization on women's access and rights to land. Drawing on the two case studies, this paper is a call for policy makers, researchers, and activists to refocus their attention to these neglected issues.

  7. User's manual for two dimensional FDTD version TEA and TMA codes for scattering from frequency-independent dielectic materials

    NASA Technical Reports Server (NTRS)

    Beggs, John H.; Luebbers, Raymond J.; Kunz, Karl S.

    1991-01-01

    The Penn State Finite Difference Time Domain Electromagnetic Scattering Code Versions TEA and TMA are two dimensional numerical electromagnetic scattering codes based upon the Finite Difference Time Domain Technique (FDTD) first proposed by Yee in 1966. The supplied version of the codes are two versions of our current two dimensional FDTD code set. This manual provides a description of the codes and corresponding results for the default scattering problem. The manual is organized into eleven sections: introduction, Version TEA and TMA code capabilities, a brief description of the default scattering geometry, a brief description of each subroutine, a description of the include files (TEACOM.FOR TMACOM.FOR), a section briefly discussing scattering width computations, a section discussing the scattering results, a sample problem set section, a new problem checklist, references and figure titles.

  8. User's manual for two dimensional FDTD version TEA and TMA codes for scattering from frequency-independent dielectric materials

    NASA Technical Reports Server (NTRS)

    Beggs, John H.; Luebbers, Raymond J.; Kunz, Karl S.

    1991-01-01

    The Penn State Finite Difference Time Domain Electromagnetic Scattering Code Versions TEA and TMA are two dimensional electromagnetic scattering codes based on the Finite Difference Time Domain Technique (FDTD) first proposed by Yee in 1966. The supplied version of the codes are two versions of our current FDTD code set. This manual provides a description of the codes and corresponding results for the default scattering problem. The manual is organized into eleven sections: introduction, Version TEA and TMA code capabilities, a brief description of the default scattering geometry, a brief description of each subroutine, a description of the include files (TEACOM.FOR TMACOM.FOR), a section briefly discussing scattering width computations, a section discussing the scattering results, a sample problem setup section, a new problem checklist, references, and figure titles.

  9. Awards, lectures, and fellowships sponsored by the AANS/CNS Section on Tumors.

    PubMed

    Lau, Darryl; Barker, Fred G; Aghi, Manish K

    2014-09-01

    A major goal of the Section on Tumors of the American Association of Neurological Surgery (AANS) and Congress of Neurological Surgeons (CNS) since it was founded in 1984 has been to foster both education and research in the field of brain tumor treatment and development. In support of this goal, the Section sponsors a number of awards, named lectures, and fellowships at the annual meetings of the AANS and CNS. In this article, we describe the awards given by the AANS/CNS Section on Tumors since its foundation, the recipients of the awards, and their philanthropic donors. The subsequent history of awardees and their work is briefly examined. Specifically for the Preuss and Mahaley Awards, this article also examines the rates of publication among the award-winning abstracts and achievement of grant funding by awardees.

  10. User's manual for three dimensional FDTD version C code for scattering from frequency-independent dielectric and magnetic materials

    NASA Technical Reports Server (NTRS)

    Beggs, John H.; Luebbers, Raymond J.; Kunz, Karl S.

    1992-01-01

    The Penn State Finite Difference Time Domain Electromagnetic Scattering Code Version C is a three-dimensional numerical electromagnetic scattering code based on the Finite Difference Time Domain (FDTD) technique. The supplied version of the code is one version of our current three-dimensional FDTD code set. The manual given here provides a description of the code and corresponding results for several scattering problems. The manual is organized into 14 sections: introduction, description of the FDTD method, operation, resource requirements, Version C code capabilities, a brief description of the default scattering geometry, a brief description of each subroutine, a description of the include file (COMMONC.FOR), a section briefly discussing radar cross section computations, a section discussing some scattering results, a new problem checklist, references, and figure titles.

  11. Concept of software interface for BCI systems

    NASA Astrophysics Data System (ADS)

    Svejda, Jaromir; Zak, Roman; Jasek, Roman

    2016-06-01

    Brain Computer Interface (BCI) technology is intended to control external system by brain activity. One of main part of such system is software interface, which carries about clear communication between brain and either computer or additional devices connected to computer. This paper is organized as follows. Firstly, current knowledge about human brain is briefly summarized to points out its complexity. Secondly, there is described a concept of BCI system, which is then used to build an architecture of proposed software interface. Finally, there are mentioned disadvantages of sensing technology discovered during sensing part of our research.

  12. Electronics for Piezoelectric Smart Structures

    NASA Technical Reports Server (NTRS)

    Warkentin, D. J.; Tani, J.

    1997-01-01

    This paper briefly presents work addressing some of the basic considerations for the electronic components used in smart structures incorporating piezoelectric elements. After general remarks on the application of piezoelectric elements to the problem of structural vibration control, three main topics are described. Work to date on the development of techniques for embedding electronic components within structural parts is presented, followed by a description of the power flow and dissipation requirements of those components. Finally current work on the development of electronic circuits for use in an 'active wall' for acoustic noise is introduced.

  13. Survey of simulation methods for modeling pulsed sieve-plate extraction columns

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Burkhart, L.

    1979-03-01

    The report first considers briefly the use of liquid-liquid extraction in nuclear fuel reprocessing and then describes the operation of the pulse column. Currently available simulation models of the column are reviewed, and followed by an analysis of the information presently available from which the necessary parameters can be obtained for use in a model of the column. Finally, overall conclusions are given regarding the information needed to develop an accurate model of the column for materials accountability in fuel reprocessing plants. 156 references.

  14. Oxidation reactions of solid carbonaceous and resinous substances in supercritical water

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Koda, S.

    Recent kinetic studies, particularly those by means of shadowgraphy and X-ray radiography, for supercritical water oxidation of solid carbonaceous and resinous substances have revealed the importance of the O{sub 2} mass transfer process over the intrinsic surface reaction at higher temperatures. The mass transfer processes, internal and external one, should be incorporated in designing SCWO processes for solid substances and related processes such as catalytic SCWO. Some model calculation efforts of late are briefly described. Finally, fundamental information required for future development is itemed.

  15. Cockpit Resource Management (CRM) and human factors training: What Air New Zealand is doing about it

    NASA Technical Reports Server (NTRS)

    Scott-Milligan, Fionna; Wyness, Bryan

    1987-01-01

    The authors have played an integral role in Air New Zealand's evaluation of CRM and Human Factors training options available to date. As the final decision as to which course is best suited to Air New Zealand's needs has yet to be made, briefly outlined are: (1) why this form of training was considered necessary; (2) the approach taken to evaluating the options available; (3) some of the problems encountered on the way; and (4) some plans for the future.

  16. Review of Development Survey of Phase Change Material Models in Building Applications

    PubMed Central

    Akeiber, Hussein J.; Wahid, Mazlan A.; Hussen, Hasanen M.; Mohammad, Abdulrahman Th.

    2014-01-01

    The application of phase change materials (PCMs) in green buildings has been increasing rapidly. PCM applications in green buildings include several development models. This paper briefly surveys the recent research and development activities of PCM technology in building applications. Firstly, a basic description of phase change and their principles is provided; the classification and applications of PCMs are also included. Secondly, PCM models in buildings are reviewed and discussed according to the wall, roof, floor, and cooling systems. Finally, conclusions are presented based on the collected data. PMID:25313367

  17. My friend Francesco Palla

    NASA Astrophysics Data System (ADS)

    Zinnecker, H.

    This is the write-up of an emotional farewell speech dedicated to the memory of Francesco Palla. It briefly summarizes Francesco's scientific legacy and also addresses his human side. Most of all, it describes some of my own memories with Francesco, including various meetings and events where we met (with photos). There are a few personal characteristics about Francesco that were not mentioned at his legacy conference which I find worth mentioning. Finally, we all agree that Francesco should be put among the stars, and some of us have suggested naming an asteroid after him.

  18. The effects of hormonal contraceptives on glycemic regulation

    PubMed Central

    Cortés, Manuel E.; Alfaro, Andrea A.

    2014-01-01

    A number of side effects have been linked to the use of hormonal contraceptives, among others, alterations in glucose levels. Hence, the objective of this mini-review is to show the main effects of hormonal contraceptive intake on glycemic regulation. First, the most relevant studies on this topic are described, then the mechanisms that might be accountable for this glycemic regulation impairment as exerted by hormonal contraceptives are discussed. Finally, we briefly discuss the ethical responsibility of health professionals to inform about the potential risks on glycemic homeostasis regarding hormonal contraceptive intake. PMID:25249703

  19. History-Enriched Spaces for Shared Encounters

    NASA Astrophysics Data System (ADS)

    Konomi, Shin'ichi; Sezaki, Kaoru; Kitsuregawa, Masaru

    We discuss "history-enriched spaces" that use historical data to support shared encounters. We first examine our experiences with DeaiExplorer, a social network display that uses RFID and a historical database to support social interactions at academic conferences. This leads to our discussions on three complementary approaches to addressing the issues of supporting social encounters: (1) embedding historical data in embodied interactions, (2) designing for weakly involved interactions such as social navigation, and (3) designing for privacy. Finally, we briefly describe a preliminary prototype of a proxemics-based awareness tool that considers these approaches.

  20. Steps to the moon

    USGS Publications Warehouse

    ,; Dale, Alvin E.

    1976-01-01

    On July 20, 1969, man walked on the surface of the Moon and began a new chapter of his studies that will eventually disclose the geologic nature of the Earth's nearest neighbor. Although he has finally reached the Moon and sampled its substance, much work and study remain before he will know the full scientific significance of the first landing. This booklet briefly summarizes the steps man has taken to understand the Moon and what he thinks he has learned to date as a result of his centuries-long speculations and studies.

  1. Phase B: Final definition and preliminary design study for the initial Atmospheric Cloud Physics Laboratory (ACPL), a spacelab mission payload

    NASA Technical Reports Server (NTRS)

    1976-01-01

    A preliminary identification of the Supporting Research and Technology (SR&T) necessary during the planned evolution of atmospheric cloud physics is discussed. All requirements are for subsequent flights over its expected ten year lifetime. Those components identified as requiring some SR&T work prior to inclusion are listed. A data sheet is included for each item, briefly justifying the need, giving general objectives for the proposed development effort and identifying approximate schedule requirements on the program.

  2. Multistability and tipping: From mathematics and physics to climate and brain-Minireview and preface to the focus issue.

    PubMed

    Feudel, Ulrike; Pisarchik, Alexander N; Showalter, Kenneth

    2018-03-01

    Multistability refers to the coexistence of different stable states in nonlinear dynamical systems. This phenomenon has been observed in laboratory experiments and in nature. In this introduction, we briefly introduce the classes of dynamical systems in which this phenomenon has been found and discuss the extension to new system classes. Furthermore, we introduce the concept of critical transitions and discuss approaches to distinguish them according to their characteristics. Finally, we present some specific applications in physics, neuroscience, biology, ecology, and climate science.

  3. High-speed atomic force microscopy coming of age

    NASA Astrophysics Data System (ADS)

    Ando, Toshio

    2012-02-01

    High-speed atomic force microscopy (HS-AFM) is now materialized. It allows direct visualization of dynamic structural changes and dynamic processes of functioning biological molecules in physiological solutions, at high spatiotemporal resolution. Dynamic molecular events unselectively appear in detail in an AFM movie, facilitating our understanding of how biological molecules operate to function. This review describes a historical overview of technical development towards HS-AFM, summarizes elementary devices and techniques used in the current HS-AFM, and then highlights recent imaging studies. Finally, future challenges of HS-AFM studies are briefly discussed.

  4. Role of the Hemostatic System on SCD Pathophysiology and Potential Therapeutics

    PubMed Central

    Pakbaz, Zahra; Wun, Ted

    2014-01-01

    Synopsis Recent studies suggest that sickle cell disease is a hypercoagulable state contributing to the vaso-occlusive events in microcirculation resulting in acute and chronic sickle cell related organ damage. In this article, we will review the existing evidence for contribution of hemostatic system perturbation to sickle cell disease pathophysiology. We will also review the data showing increased risk of thromboembolic events, particularly newer information on the incidence of VTE. Finally, the potential role of platelet inhibitors and anticoagulants in SCD will be briefly reviewed. PMID:24589271

  5. Polymer – drug conjugates: Origins, progress to date and future directions

    PubMed Central

    Kopeček, Jindřich

    2012-01-01

    This overview focuses on bioconjugates of water-soluble polymers with low molecular weight drugs and proteins. After a short discussion of the origins of the field, the state-of-the-art is reviewed. Then research directions needed for the acceleration of the translation of nanomedicines into the clinic are outlined. Two most important directions, synthesis of backbone degradable polymer carriers and drug-free macromolecular therapeutics, a new paradigm in drug delivery, are discussed in detail. Finally, the future perspectives of the field are briefly discussed. PMID:23123294

  6. OSHA standard for medical surveillance of hazardous waste workers.

    PubMed

    Melius, J M

    1990-01-01

    The increasing amount of work involving hazardous waste sites and the heavy involvement of the federal and state governments in this work have led to the gradual development of guidelines and standards providing for occupational safety and health programs for these sites. On March 6, 1989, the Occupational Safety and Health Administration published its final rule governing occupational safety and health matters at hazardous waste sites and emergency operations. This rule is currently scheduled to take effect on March 6, 1990. This chapter will briefly describe this regulation, particularly its medical surveillance requirements.

  7. People and computers--some recent highlights.

    PubMed

    Shackel, B

    2000-12-01

    This paper aims to review selectively a fair proportion of the literature on human-computer interaction (HCI) over the three years since Shackel (J. Am. Soc. Inform. Sci. 48 (11) (1997) 970-986). After a brief note of history I discuss traditional input, output and workplace aspects, the web and 'E-topics', web-related aspects, virtual reality, safety-critical systems, and the need to move from HCI to human-system integration (HSI). Finally I suggest, and consider briefly, some future possibilities and issues including web consequences, embedded ubiquitous computing, and 'back to systems ergonomics?'.

  8. Including Finite Surface Span Effects in Empirical Jet-Surface Interaction Noise Models

    NASA Technical Reports Server (NTRS)

    Brown, Clifford A.

    2016-01-01

    The effect of finite span on the jet-surface interaction noise source and the jet mixing noise shielding and reflection effects is considered using recently acquired experimental data. First, the experimental setup and resulting data are presented with particular attention to the role of surface span on far-field noise. These effects are then included in existing empirical models that have previously assumed that all surfaces are semi-infinite. This extended abstract briefly describes the experimental setup and data leaving the empirical modeling aspects for the final paper.

  9. [30 years since the first AIDS cases were reported: history and the present. Part I].

    PubMed

    Brůcková, Marie

    2012-05-01

    The 30-year natural history of AIDS disease is presented from the first clinical cases reported in 1981 to the identification of the HIV as the etiological agent of the disease. The priority dispute between Robert C. Gallo and Luc Montagnier over the discovery of the human immunodeficiency virus is briefly addressed. The final confirmation of the French priority was provided by the fact that the Nobel Prize in Medicine 2008 was awarded to Luc Montagnier and Francoise Barré--Sinoussi from the Pasteur Institute in Paris.

  10. Community access to health information in Ireland.

    PubMed

    Macdougall, J

    1999-06-01

    This paper is based on a research project conducted on consumer health information (CHI) in the Republic of Ireland, the results of which were published in a report entitled Well Read: Developing Consumer Health Information in Ireland. The paper describes the research methodology and the Irish experience in relation to CHI followed by a discussion of access problems, illustrated with examples from the special needs and primary care sectors. The role of information providers in relation to primary healthcare and libraries is examined briefly, and finally the main research conclusions and recommendations are highlighted.

  11. NEUROBILOGY OF ASPERGER'S SYNDROME : A CASE STUDY AND OVERVIEW

    PubMed Central

    Duggal, Harpreet S.; Dutta, Siddhartha; Sinha, Vinod K.; Basu, Soumya; Pandey, Smita; Nizamie, Haque S.; Nizamie, Alka

    2001-01-01

    Asperger's syndrome is an autistic spectrum disorder, which has engendered lesser attention in comparison to autism. Recent literature has focused on the involvement of cortical areas of the brain in this syndrome. We report a case of Asperger′s syndrome in which an extensive work-up, including neuropsychological, neurophysiological and neuroimaging procedures, were undertaken. The findings of the various investigative procedures are discussed and literature supporting the neurobiological basis of Asperger's syndrome is highlighted. Finally, we briefly touch upon the ‘Theory of Mind’ construct in autistic spectrum disorders. PMID:21407867

  12. Aerosol Data Assimilation at GMAO

    NASA Technical Reports Server (NTRS)

    da Silva, Arlindo M.; Buchard, Virginie

    2017-01-01

    This presentation presents an overview of the aerosol data assimilation work performed at GMAO. The GMAO Forward Processing system and the biomass burning emissions from QFED are first presented. Then, the current assimilation of Aerosol Optical Depth (AOD), performed by means of the analysis splitting method is briefly described, followed by some results on the quality control of observations using a Neural Network trained using AERONET AOD. Some applications are shown such as the Mount Pinatubo eruption in 1991 using the MERRA-2 aerosol dataset. Finally preliminary results on the EnKF implementation for aerosol assimilation are presented.

  13. Introduction to nanotechnology: a short course for high school students

    NASA Astrophysics Data System (ADS)

    Markin, Alexey V.

    2016-04-01

    This report devoted to presenting results of development and implementation of a short course (4 hours) entitled "Introduction to Nanotechnology" that was specially designed for familiarizing high school students with nanomaterials and nanotechnology. The course contains introduction to nanotechnology, essential definitions, short overview of history, descriptions for various examples of nanomaterials and their classifications, performing demonstration experiments. All these parts of the course are briefly analyzed from pedagogical effectiveness point of view. Finally, results of course testing, problems and perspectives of nano-oriented education at high school are also discussed shortly.

  14. Real-time functional magnetic imaging-brain-computer interface and virtual reality promising tools for the treatment of pedophilia.

    PubMed

    Renaud, Patrice; Joyal, Christian; Stoleru, Serge; Goyette, Mathieu; Weiskopf, Nikolaus; Birbaumer, Niels

    2011-01-01

    This chapter proposes a prospective view on using a real-time functional magnetic imaging (rt-fMRI) brain-computer interface (BCI) application as a new treatment for pedophilia. Neurofeedback mediated by interactive virtual stimuli is presented as the key process in this new BCI application. Results on the diagnostic discriminant power of virtual characters depicting sexual stimuli relevant to pedophilia are given. Finally, practical and ethical implications are briefly addressed. Copyright © 2011 Elsevier B.V. All rights reserved.

  15. Glass processing in a microgravity environment

    NASA Technical Reports Server (NTRS)

    Uhlmann, D. R.

    1982-01-01

    The basic techniques used in the processing of glasses and crystalline ceramics under terrestrial conditions are briefly reviewed, and the features of the space environment relevant to the processing of glasses are examined. These include reduced gravitational forces, a vacuum of essentially unlimited pumping capacity, unique radiation conditions, and the unlimited dimensions of space. Of these factors, particular attention is given to reduced gravitational forces, and the advantages of containerless processing are discussed. Finally, current programs concerned with glass processing in space are reviewed along with additional areas which merit investigation.

  16. Environmental restraints and life strategies: a habitat templet matrix.

    PubMed

    Holm, E

    1988-02-01

    Four basic environmental restraints on life are deduced from the requirements of life's inherent order laws. Possible life strategies to contend with these restraints are listed. The various combinations of the restraints are subsequently investigated, and appropriate combinations of life strategies are fitted. This model is finally tested against insect case histories in various environments, and is demonstrated to explain some combinations of characteristics of insects in ecosystems not covered by the r-K or r-K-A continua. The role of heterochrony in achieving appropriate life strategies is briefly discussed.

  17. Multistability and tipping: From mathematics and physics to climate and brain—Minireview and preface to the focus issue

    NASA Astrophysics Data System (ADS)

    Feudel, Ulrike; Pisarchik, Alexander N.; Showalter, Kenneth

    2018-03-01

    Multistability refers to the coexistence of different stable states in nonlinear dynamical systems. This phenomenon has been observed in laboratory experiments and in nature. In this introduction, we briefly introduce the classes of dynamical systems in which this phenomenon has been found and discuss the extension to new system classes. Furthermore, we introduce the concept of critical transitions and discuss approaches to distinguish them according to their characteristics. Finally, we present some specific applications in physics, neuroscience, biology, ecology, and climate science.

  18. High resolution observations using adaptive optics: Achievements and future needs

    NASA Astrophysics Data System (ADS)

    Sankarasubramanian, K.; Rimmele, T.

    2008-06-01

    Over the last few years, several interesting observations were obtained with the help of solar Adaptive Optics (AO). In this paper, few observations made using the solar AO are enlightened and briefly discussed. A list of disadvantages with the current AO system are presented. With telescopes larger than 1.5 m expected during the next decade, there is a need to develop the existing AO technologies for large aperture telescopes. Some aspects of this development are highlighted. Finally, the recent AO developments in India are also presented.

  19. Tip-Based Nanofabrication for Scalable Manufacturing

    DOE PAGES

    Hu, Huan; Kim, Hoe; Somnath, Suhas

    2017-03-16

    Tip-based nanofabrication (TBN) is a family of emerging nanofabrication techniques that use a nanometer scale tip to fabricate nanostructures. Here in this review, we first introduce the history of the TBN and the technology development. We then briefly review various TBN techniques that use different physical or chemical mechanisms to fabricate features and discuss some of the state-of-the-art techniques. Subsequently, we focus on those TBN methods that have demonstrated potential to scale up the manufacturing throughput. Finally, we discuss several research directions that are essential for making TBN a scalable nano-manufacturing technology.

  20. Book Catalogs versus Card Catalogs *

    PubMed Central

    Pizer, Irwin H.

    1965-01-01

    The development of the library catalog in book form and its abandonment in favor of the card catalog are briefly traced. The advantages and disadvantages of both types of catalogs are enumerated, and several solutions which tried to combine the best features of both are discussed. The present trend back to the book catalog, made possible by recent advances in computer technology, is analyzed, advantages and disadvantages are compared, current examples are illustrated, and finally the computerized catalog is weighed against both the book and card catalog as to main features and practicality. PMID:14271116

  1. Tip-Based Nanofabrication for Scalable Manufacturing

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hu, Huan; Kim, Hoe; Somnath, Suhas

    Tip-based nanofabrication (TBN) is a family of emerging nanofabrication techniques that use a nanometer scale tip to fabricate nanostructures. Here in this review, we first introduce the history of the TBN and the technology development. We then briefly review various TBN techniques that use different physical or chemical mechanisms to fabricate features and discuss some of the state-of-the-art techniques. Subsequently, we focus on those TBN methods that have demonstrated potential to scale up the manufacturing throughput. Finally, we discuss several research directions that are essential for making TBN a scalable nano-manufacturing technology.

  2. Tracing Cosmic Dawn

    NASA Astrophysics Data System (ADS)

    Fialkov, Anastasia

    2018-05-01

    Observational effort is on the way to probe the 21-cm of neutral hydrogen from the epochs of Reionization and Cosmic Dawn. Our current poor knowledge of high redshift astrophysics results in a large uncertainty in the theoretically predicted 21-cm signal. A recent parameter study that is highlighted here explores the variety of 21-cm signals resulting from viable astrophysical scenarios. Model-independent relations between the shape of the signal and the underlying astrophysics are discussed. Finally, I briefly note on possible alternative probes of the high redshift Universe, specifically Fast Radio Bursts.

  3. Operation and performance of the LHCb calorimeters

    NASA Astrophysics Data System (ADS)

    Chefdeville, M.

    2018-03-01

    The LHCb calorimeters play a key role in the hardware trigger of the experiment. They also serve the measurement of radiative heavy flavor decays and the identification of electrons. Located at twelve meters from the interaction region, they are composed of a plane of scintillating tiles, a preshower detector, an electromagnetic and a hadronic sampling calorimeters using scintillators as active elements. In these proceedings, technical and operational aspects of these detectors are described. Emphasis is then put on calorimeter reconstruction and calibration. Finally, performance for benchmark physics modes are briefly reported.

  4. Wide-Field InfraRed Survey Telescope (WFIRST) Slitless Spectrometer: Design, Prototype, and Results

    NASA Technical Reports Server (NTRS)

    Gong, Qian; Content, David; Dominguez, Margaret; Emmett, Thomas; Griesmann, Ulf; Hagopian, John; Kruk, Jeffrey; Marx, Catherine; Pasquale, Bert; Wallace, Thomas; hide

    2016-01-01

    The slitless spectrometer plays an important role in the Wide-Field InfraRed Survey Telescope (WFIRST) mission for the survey of emission-line galaxies. This will be an unprecedented very wide field, HST quality 3D survey of emission line galaxies. The concept of the compound grism as a slitless spectrometer has been presented previously. The presentation briefly discusses the challenges and solutions of the optical design, and recent specification updates, as well as a brief comparison between the prototype and the latest design. However, the emphasis of this paper is the progress of the grism prototype: the fabrication and test of the complicated diffractive optical elements and powered prism, as well as grism assembly alignment and testing. Especially how to use different tools and methods, such as IR phase shift and wavelength shift interferometry, to complete the element and assembly tests. The paper also presents very encouraging results from recent element tests to assembly tests. Finally we briefly touch the path forward plan to test the spectral characteristic, such as spectral resolution and response.

  5. Some developments from the work of Melanie Klein.

    PubMed

    Spillius, E B

    1983-01-01

    This paper discusses four areas of work in which several followers of Melanie Klein in Britain have developed some of the discoveries and ideas she initiated. First, extension of her concept of projective identification is briefly described, with emphasis on Bion's and Rosenfeld's stress on its communicative as well as its pathological aspects. Second, the extension of Klein's ideas about the epistemophilic instinct, on symbolism, and about projective identification is described in the work of Segal, Bion, Money-Kyrle, and Bick on the development of the capacity to think. Third, certain developments in Kleinian technique are described, with emphasis on the use of the concept of projective identification in analysing transference, and on the analysis of acting out in the transference, a trend contributed to by many Kleinian analysts but perhaps most closely associated with Betty Joseph. Finally, continued refinements in the analysis of the death instinct are briefly described, together with discussion of the changes these refinements have led to in ideas about the organization and relations of parts of the self and internal objects.

  6. Obesity and Headache: Part I – A Systematic Review of the Epidemiology of Obesity and Headache

    PubMed Central

    Chai, Nu Cindy; Scher, Ann I.; Moghekar, Abhay; Bond, Dale S.; Peterlin, B. Lee

    2014-01-01

    Individually, both obesity and headache are conditions associated with a substantial personal and societal impact. Recent data support that obesity is comorbid with headache in general and migraine specifically, as well as with certain secondary headache conditions such as idiopathic intracranial hypertension. In the current manuscript, we first briefly review the epidemiology of obesity and common primary and secondary headache disorders individually. This is followed by a systematic review of the general population data evaluating the association between obesity and headache in general, and then obesity and migraine and tension-type headache disorders. Finally, we briefly discuss the data on the association between obesity and a common secondary headache disorder that is associated with obesity, idiopathic intracranial hypertension. Taken together, these data suggest that it is important for clinicians and patients to be aware of the headache/migraine-obesity association, given that it is potentially modifiable. Hypotheses for mechanisms of the obesity-migraine association and treatment considerations for overweight and obese headache sufferers are discussed in the companion manuscript, as part II of this topic. PMID:24512574

  7. Fluid Physics in a Fluctuating Acceleration Environment

    NASA Technical Reports Server (NTRS)

    Thomson, J. Ross; Drolet, Francois; Vinals, Jorge

    1996-01-01

    We summarize several aspects of an ongoing investigation of the effects that stochastic residual accelerations (g-jitter) onboard spacecraft can have on experiments conducted in a microgravity environment. The residual acceleration field is modeled as a narrow band noise, characterized by three independent parameters: intensity (g(exp 2)), dominant angular frequency Omega, and characteristic correlation time tau. Realistic values for these parameters are obtained from an analysis of acceleration data corresponding to the SL-J mission, as recorded by the SAMS instruments. We then use the model to address the random motion of a solid particle suspended in an incompressible fluid subjected to such random accelerations. As an extension, the effect of jitter on coarsening of a solid-liquid mixture is briefly discussed, and corrections to diffusion controlled coarsening evaluated. We conclude that jitter will not be significant in the experiment 'Coarsening of solid-liquid mixtures' to be conducted in microgravity. Finally, modifications to the location of onset of instability in systems driven by a random force are discussed by extending the standard reduction to the center manifold to the stochastic case. Results pertaining to time-modulated oscillatory convection are briefly discussed.

  8. Environmental Chemicals and Aging.

    PubMed

    Pearson, Brandon L; Ehninger, Dan

    2017-03-01

    Innovations in agriculture and medicine as well as industrial and domestic technologies are essential for the growing and aging global population. These advances generally require the use of novel natural or synthetic chemical agents with the potential to affect human health. Here, we attempt to highlight environmental chemicals and select drugs with the potential to exacerbate aging by directly affecting molecular aging cascades focusing particular attention on the brain. Finally, we call attention to some potential fruitful areas of research, particularly with advanced molecular profiling that could aid in prevention or mitigation of environmental chemical toxic influences in the periphery and the brain. We briefly summarize new research and highlight a recent study designed to prospectively identify agrochemicals with the potential to induce neurological diseases and place these discoveries into the already rich neurodegeneration and aging literature. Collectively, the research reviewed briefly here highlight chemicals with the true potential to accelerate aging, particularly in the brain, by eliciting elevated free radical stress and mitochondrial dysfunction. We make general recommendations about improved methodological approaches toward identification and regulation of chemicals that are gerontogenic to the brain.

  9. [Research on magnetic coupling centrifugal blood pump control based on a self-tuning fuzzy PI algorithm].

    PubMed

    Yang, Lei; Yang, Ming; Xu, Zihao; Zhuang, Xiaoqi; Wang, Wei; Zhang, Haibo; Han, Lu; Xu, Liang

    2014-10-01

    The purpose of this paper is to report the research and design of control system of magnetic coupling centrifugal blood pump in our laboratory, and to briefly describe the structure of the magnetic coupling centrifugal blood pump and principles of the body circulation model. The performance of blood pump is not only related to materials and structure, but also depends on the control algorithm. We studied the algorithm about motor current double-loop control for brushless DC motor. In order to make the algorithm adjust parameter change in different situations, we used the self-tuning fuzzy PI control algorithm and gave the details about how to design fuzzy rules. We mainly used Matlab Simulink to simulate the motor control system to test the performance of algorithm, and briefly introduced how to implement these algorithms in hardware system. Finally, by building the platform and conducting experiments, we proved that self-tuning fuzzy PI control algorithm could greatly improve both dynamic and static performance of blood pump and make the motor speed and the blood pump flow stable and adjustable.

  10. Strategic Aspects of Communication

    NASA Astrophysics Data System (ADS)

    Hagen, Edward; Hammerstein, Peter; Hess, Nicole

    Rarely do human behavioral scientists and scholars study language, music, and other forms of communication as strategies—a means to some end. Some even deny that communication is the primary function of these phenomena. Here we draw upon selections of our earlier work to briefly define the strategy concept and sketch how decision theory, developed to explain the behavior of rational actors, is applied to evolved agents. Communication can then be interpreted as a strategy that advances the "fitness interests" of such agents. When this perspective is applied to agents with conflicts of interest, deception emerges as an important aspect of communication. We briefly review costly signaling, one solution to the problem of honest communication among agents with conflicts of interest. We also explore the subversion of cooperative signals by parasites and by plants defending themselves against herbivores, and we touch on biases in human gossip. Experiments with artificial embodied and communicating agents confirm that when there are conflicts of interest among agents, deception readily evolves. Finally, we consider signaling among super-organisms and the possible implications for understanding human music and language.

  11. Overview of Medicinally Important Diterpenoids Derived from Plastids.

    PubMed

    Zhang, Linsu; Lu, Shanfa

    2017-01-01

    FL 32608 Terpenoids are hydrocarbon compounds derived from common fivecarbon isoprene (C5H8) building blocks. They are formed through the condensation and subsequent modification of isoprene units in various ways including - among others - cyclization and/or oxygenation. Their synthesis is localized either to the chloroplast and/or to the cytoplasm/peroxisome/ endoplasmic reticulum and mitochondrion. Terpenoids represent a very large and diverse class of metabolites and play important roles in plant growth and development. In addition, they have been intensively used in human health care, disease treatment and in dietary supplements. Approximately 60% of natural products known so far are terpenoids. This review briefly summarizes the biosynthetic pathways of major plant terpenoids. Then, five well-known and medicinally important diterpenoids, including paclitaxel, tanshinone, ginkgolide, triptolide and oridonin are discussed in detail. Their structures, occurrence, extraction and identification methods, pharmacological properties and clinical uses are also reviewed. Finally, the prospects of using biotechnology to produce medicinally important terpenoids are also briefly discussed. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  12. On 3-D inelastic analysis methods for hot section components (base program)

    NASA Technical Reports Server (NTRS)

    Wilson, R. B.; Bak, M. J.; Nakazawa, S.; Banerjee, P. K.

    1986-01-01

    A 3-D Inelastic Analysis Method program is described. This program consists of a series of new computer codes embodying a progression of mathematical models (mechanics of materials, special finite element, boundary element) for streamlined analysis of: (1) combustor liners, (2) turbine blades, and (3) turbine vanes. These models address the effects of high temperatures and thermal/mechanical loadings on the local (stress/strain)and global (dynamics, buckling) structural behavior of the three selected components. Three computer codes, referred to as MOMM (Mechanics of Materials Model), MHOST (Marc-Hot Section Technology), and BEST (Boundary Element Stress Technology), have been developed and are briefly described in this report.

  13. Recent applications of carbon-based nanomaterials in analytical chemistry: critical review.

    PubMed

    Scida, Karen; Stege, Patricia W; Haby, Gabrielle; Messina, Germán A; García, Carlos D

    2011-04-08

    The objective of this review is to provide a broad overview of the advantages and limitations of carbon-based nanomaterials with respect to analytical chemistry. Aiming to illustrate the impact of nanomaterials on the development of novel analytical applications, developments reported in the 2005-2010 period have been included and divided into sample preparation, separation, and detection. Within each section, fullerenes, carbon nanotubes, graphene, and composite materials will be addressed specifically. Although only briefly discussed, included is a section highlighting nanomaterials with interesting catalytic properties that can be used in the design of future devices for analytical chemistry. Copyright © 2011 Elsevier B.V. All rights reserved.

  14. Recent Applications of Carbon-Based Nanomaterials in Analytical Chemistry: Critical Review

    PubMed Central

    Scida, Karen; Stege, Patricia W.; Haby, Gabrielle; Messina, Germán A.; García, Carlos D.

    2011-01-01

    The objective of this review is to provide a broad overview of the advantages and limitations of carbon-based nanomaterials with respect to analytical chemistry. Aiming to illustrate the impact of nanomaterials on the development of novel analytical applications, developments reported in the 2005–2010 period have been included and divided into sample preparation, separation, and detection. Within each section, fullerenes, carbon nanotubes, graphene, and composite materials will be addressed specifically. Although only briefly discussed, included is a section highlighting nanomaterials with interesting catalytic properties that can be used in the design of future devices for analytical chemistry. PMID:21458626

  15. Vision science and schizophrenia research: toward a re-view of the disorder. Editors' introduction to special section.

    PubMed

    Silverstein, Steven M; Keane, Brian P

    2011-07-01

    This theme section on vision science and schizophrenia research demonstrates that our understanding of the disorder could be significantly accelerated by a greater adoption of the methods of vision science. In this introduction, we briefly describe what vision science is, how it has advanced our understanding of schizophrenia, and what challenges and opportunities lay ahead regarding schizophrenia research. We then summarize the articles that follow. These include reviews of abnormal form perception (perceptual organization and backward masking) and motion processing, and an article on reduced size contrast illusions experienced by hearing but not deaf persons with schizophrenia. These articles reveal that the methods of basic vision research can provide insights into a number of aspects of the disorder, including pathophysiology, development, cognition, social cognition, and phenomenology. Importantly, studies of visual processing in schizophrenia make it clear that there are impairments in the functioning of basic neural mechanisms (e.g., center-surround modulation, contextual modulation of feedforward processing, reentrant processing) that are found throughout the cortex and that are operative in multiple forms of cognitive dysfunction in the illness. Such evidence allows for an updated view of schizophrenia as a condition involving generalized failures in neural network formation and maintenance, as opposed to a primary failure in a higher level factor (e.g., cognitive control) that accounts for all other types of perceptual and cognitive dysfunction. Finally, studies of vision in schizophrenia can identify sensitive probes of neural functioning that can be used as biomarkers of treatment response.

  16. Vision Science and Schizophrenia Research: Toward a Re-view of the Disorder Editors’ Introduction to Special Section

    PubMed Central

    Silverstein, Steven M.; Keane, Brian P.

    2011-01-01

    This theme section on vision science and schizophrenia research demonstrates that our understanding of the disorder could be significantly accelerated by a greater adoption of the methods of vision science. In this introduction, we briefly describe what vision science is, how it has advanced our understanding of schizophrenia, and what challenges and opportunities lay ahead regarding schizophrenia research. We then summarize the articles that follow. These include reviews of abnormal form perception (perceptual organization and backward masking) and motion processing, and an article on reduced size contrast illusions experienced by hearing but not deaf persons with schizophrenia. These articles reveal that the methods of basic vision research can provide insights into a number of aspects of the disorder, including pathophysiology, development, cognition, social cognition, and phenomenology. Importantly, studies of visual processing in schizophrenia make it clear that there are impairments in the functioning of basic neural mechanisms (eg, center-surround modulation, contextual modulation of feedforward processing, reentrant processing) that are found throughout the cortex and that are operative in multiple forms of cognitive dysfunction in the illness. Such evidence allows for an updated view of schizophrenia as a condition involving generalized failures in neural network formation and maintenance, as opposed to a primary failure in a higher level factor (eg, cognitive control) that accounts for all other types of perceptual and cognitive dysfunction. Finally, studies of vision in schizophrenia can identify sensitive probes of neural functioning that can be used as biomarkers of treatment response. PMID:21700588

  17. What Are Plans For?

    DTIC Science & Technology

    1988-09-01

    does determine an agent’s actions? Answering this question is the job of a theory of activity. After briefly summarizing our understanding of activity in...this section, we will return to the question of the role of plans in activity. Our theory of activity has two interconstraining parts: a theory of...cognitive machinery and a theory of the dynamics or regularly occurring patterns of activity. In studying people we ask (i) how is ordinary human

  18. Development of in Vivo Biomarkers for Progressive Tau Pathology after Traumatic Brain Injury

    DTIC Science & Technology

    2017-11-01

    Psychological medicine 1973;3:270-303. 3. Jordan BD. Chronic traumatic brain injury associated with boxing. Seminars in neurology 2000;20:179- 185...astrogliosis in sham or injured animals. In summary, we show that repetitive brain injury produces persistent behavioral abnormalities as late as one...sections, we used power coherence as a measure of white matter integrity as previously described.32 Briefly, each ROI was subdivided into square

  19. Pressure and Force Characteristics of Noncircular Cylinders as Affected by Reynolds Number with a Method Included for Determining the Potential Flow About Arbitrary Shapes

    NASA Technical Reports Server (NTRS)

    Polhamus, Edward C.; Geller, Edward W.; Grunwald, Kalman J.

    1959-01-01

    The low-speed pressure-distribution and force characteristics of several noncircular two-dimensional cylinders were measured in wind tunnel through a range of Reynolds numbers and flow incidences. A method of determining the potential-flow pressure distribution for arbitrary cross sections is described. Application of the data in predicting the spin characteristics of fuselages is briefly discussed.

  20. 20 CFR 636.11 - Final action.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Final action. 636.11 Section 636.11 Employees... HEARINGS § 636.11 Final action. The final decision of the Secretary pursuant to section 166(b) of the Act... Officer's final determination where there has been no such hearing, constitutes final agency action within...

  1. 20 CFR 636.11 - Final action.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Final action. 636.11 Section 636.11 Employees... HEARINGS § 636.11 Final action. The final decision of the Secretary pursuant to section 166(b) of the Act... Officer's final determination where there has been no such hearing, constitutes final agency action within...

  2. The U.S. Geological Survey Modular Ground-Water Model - PCGN: A Preconditioned Conjugate Gradient Solver with Improved Nonlinear Control

    USGS Publications Warehouse

    Naff, Richard L.; Banta, Edward R.

    2008-01-01

    The preconditioned conjugate gradient with improved nonlinear control (PCGN) package provides addi-tional means by which the solution of nonlinear ground-water flow problems can be controlled as compared to existing solver packages for MODFLOW. Picard iteration is used to solve nonlinear ground-water flow equations by iteratively solving a linear approximation of the nonlinear equations. The linear solution is provided by means of the preconditioned conjugate gradient algorithm where preconditioning is provided by the modi-fied incomplete Cholesky algorithm. The incomplete Cholesky scheme incorporates two levels of fill, 0 and 1, in which the pivots can be modified so that the row sums of the preconditioning matrix and the original matrix are approximately equal. A relaxation factor is used to implement the modified pivots, which determines the degree of modification allowed. The effects of fill level and degree of pivot modification are briefly explored by means of a synthetic, heterogeneous finite-difference matrix; results are reported in the final section of this report. The preconditioned conjugate gradient method is coupled with Picard iteration so as to efficiently solve the nonlinear equations associated with many ground-water flow problems. The description of this coupling of the linear solver with Picard iteration is a primary concern of this document.

  3. Optical filters for wavelength selection in fluorescence instrumentation.

    PubMed

    Erdogan, Turan

    2011-04-01

    Fluorescence imaging and analysis techniques have become ubiquitous in life science research, and they are poised to play an equally vital role in in vitro diagnostics (IVD) in the future. Optical filters are crucial for nearly all fluorescence microscopes and instruments, not only to provide the obvious function of spectral control, but also to ensure the highest possible detection sensitivity and imaging resolution. Filters make it possible for the sample to "see" light within only the absorption band, and the detector to "see" light within only the emission band. Without filters, the detector would not be able to distinguish the desired fluorescence from scattered excitation light and autofluorescence from the sample, substrate, and other optics in the system. Today the vast majority of fluorescence instruments, including the widely popular fluorescence microscope, use thin-film interference filters to control the spectra of the excitation and emission light. Hence, this unit emphasizes thin-film filters. After briefly introducing different types of thin-film filters and how they are made, the unit describes in detail different optical filter configurations in fluorescence instruments, including both single-color and multicolor imaging systems. Several key properties of thin-film filters, which can significantly affect optical system performance, are then described. In the final section, tunable optical filters are also addressed in a relative comparison.

  4. Application of stochastic inversion in auroral tomography

    NASA Astrophysics Data System (ADS)

    Nygrén, T.; Markkanen, M.; Lehtinen, M.; Kaila, K.

    1996-11-01

    A software package originally developed for satellite radio tomography is briefly introduced and its use in two-dimensional auroral tomography is described. The method is based on stochastic inversion, i.e. finding the most probable values of the unknown volume emission rates once the optical measurements are made using either a scanning photometer or an auroral camera. A set of simulation results is shown for a different number and separations of optical instruments at ground level. It is observed that arcs with a thickness of a few kilometers and separated by a few tens of kilometers are easily reconstructed. The maximum values of the inversion results, however, are often weaker than in the model. The most obvious reason for this is the grid size, which cannot be much smaller than the arc thickness. The grid necessarily generates a spatial averaging effect broadening the arc cross-sections and reducing the peak values. Finally, results from TV-camera observations at Tromsø and Esrange are shown. Although these sites are separated by more than 200 km, arcs close to Tromsø have been successfully reconstructed. Acknowledgements. The work done by P. Henelius and E. Vilenius in programme development is gratefully acknowledged. Topical Editor D. Alcayde thanks I. Pryse and A. Vallance-Jones for their help in evaluating this paper.--> Correspondence to: T. Nygrén-->

  5. Photophysics of sunscreen molecules in the gas phase: a stepwise approach towards understanding and developing next-generation sunscreens

    PubMed Central

    Rodrigues, Natércia D. N.; Staniforth, Michael

    2016-01-01

    The relationship between exposure to ultraviolet (UV) radiation and skin cancer urges the need for extra photoprotection, which is presently provided by widespread commercially available sunscreen lotions. Apart from having a large absorption cross section in the UVA and UVB regions of the electromagnetic spectrum, the chemical absorbers in these photoprotective products should also be able to dissipate the excess energy in a safe way, i.e. without releasing photoproducts or inducing any further, harmful, photochemistry. While sunscreens are tested for both their photoprotective capability and dermatological compatibility, phenomena occurring at the molecular level upon absorption of UV radiation are largely overlooked. To date, there is only a limited amount of information regarding the photochemistry and photophysics of these sunscreen molecules. However, a thorough understanding of the intrinsic mechanisms by which popular sunscreen molecular constituents dissipate excess energy has the potential to aid in the design of more efficient, safer sunscreens. In this review, we explore the potential of using gas-phase frequency- and time-resolved spectroscopies in an effort to better understand the photoinduced excited-state dynamics, or photodynamics, of sunscreen molecules. Complementary computational studies are also briefly discussed. Finally, the future outlook of expanding these gas-phase studies into the solution phase is considered. PMID:27956888

  6. Photophysics of sunscreen molecules in the gas phase: a stepwise approach towards understanding and developing next-generation sunscreens

    NASA Astrophysics Data System (ADS)

    Rodrigues, Natércia D. N.; Staniforth, Michael; Stavros, Vasilios G.

    2016-11-01

    The relationship between exposure to ultraviolet (UV) radiation and skin cancer urges the need for extra photoprotection, which is presently provided by widespread commercially available sunscreen lotions. Apart from having a large absorption cross section in the UVA and UVB regions of the electromagnetic spectrum, the chemical absorbers in these photoprotective products should also be able to dissipate the excess energy in a safe way, i.e. without releasing photoproducts or inducing any further, harmful, photochemistry. While sunscreens are tested for both their photoprotective capability and dermatological compatibility, phenomena occurring at the molecular level upon absorption of UV radiation are largely overlooked. To date, there is only a limited amount of information regarding the photochemistry and photophysics of these sunscreen molecules. However, a thorough understanding of the intrinsic mechanisms by which popular sunscreen molecular constituents dissipate excess energy has the potential to aid in the design of more efficient, safer sunscreens. In this review, we explore the potential of using gas-phase frequency- and time-resolved spectroscopies in an effort to better understand the photoinduced excited-state dynamics, or photodynamics, of sunscreen molecules. Complementary computational studies are also briefly discussed. Finally, the future outlook of expanding these gas-phase studies into the solution phase is considered.

  7. Randomization in cancer clinical trials: permutation test and development of a computer program.

    PubMed Central

    Ohashi, Y

    1990-01-01

    When analyzing cancer clinical trial data where the treatment allocation is done using dynamic balancing methods such as the minimization method for balancing the distribution of important prognostic factors in each arm, conservativeness occurs if such a randomization scheme is ignored and a simple unstratified analysis is carried out. In this paper, the above conservativeness is demonstrated by computer simulation, and the development of a computer program that carries out permutation tests of the log-rank statistics for clinical trial data where the allocation is done by the minimization method or a stratified permuted block design is introduced. We are planning to use this program in practice to supplement a usual stratified analysis and model-based methods such as the Cox regression. The most serious problem in cancer clinical trials in Japan is how to carry out the quality control or data management in trials that are initiated and conducted by researchers without support from pharmaceutical companies. In the final section of this paper, one international collaborative work for developing international guidelines on data management in clinical trials of bladder cancer is briefly introduced, and the differences between the system adopted in US/European statistical centers and the Japanese system is described. PMID:2269216

  8. Synthesis meets theory: Past, present and future of rational chemistry

    NASA Astrophysics Data System (ADS)

    Fianchini, Mauro

    2017-11-01

    Chemical synthesis has its roots in the empirical approach of alchemy. Nonetheless, the birth of the scientific method, the technical and technological advances (exploiting revolutionary discoveries in physics) and the improved management and sharing of growing databases greatly contributed to the evolution of chemistry from an esoteric ground into a mature scientific discipline during these last 400 years. Furthermore, thanks to the evolution of computational resources, platforms and media in the last 40 years, theoretical chemistry has added to the puzzle the final missing tile in the process of "rationalizing" chemistry. The use of mathematical models of chemical properties, behaviors and reactivities is nowadays ubiquitous in literature. Theoretical chemistry has been successful in the difficult task of complementing and explaining synthetic results and providing rigorous insights when these are otherwise unattainable by experiment. The first part of this review walks the reader through a concise historical overview on the evolution of the "model" in chemistry. Salient milestones have been highlighted and briefly discussed. The second part focuses more on the general description of recent state-of-the-art computational techniques currently used worldwide by chemists to produce synergistic models between theory and experiment. Each section is complemented by key-examples taken from the literature that illustrate the application of the technique discussed therein.

  9. Prizes, lectures, and awards of the American Association of Neurological Surgeons/Congress of Neurological Surgeons Section on Tumors.

    PubMed

    Barker, Fred G; McDermott, Michael W

    2005-04-15

    An important goal of the Section on Tumors of the American Association of Neurological Surgeons (AANS) and Congress of Neurological Surgeons (CNS) since its founding in 1985 has been to foster both education and research in the field of brain tumor treatment. As one means of achieving this, the Section awards a number of prizes, research grants, and named lectures at the annual meetings of the AANS and CNS. After a brief examination of similar honors that were given in recognition of pioneering work by Knapp, Cushing, and other early brain tumor researchers, the authors describe the various awards given by the AANS/CNS Section on Tumors since its founding, their philanthropic donors, and the recipients of the awards. The subsequent career of the recipients is briefly examined, in terms of the rate of full publication of award-winning abstracts and achievement of grant funding by awardees.

  10. NASA Publications Guide for Authors

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Publication of scientific and technical information (STI) is one of the responsibilities of NASA as a Government Agency. The National Aeronautics and Space Act of 1958 established a requirement for NASA to provide "the widest practicable and appropriate dissemination of information concerning its activities and the results thereof." Persons engaged in NASA-funded or NASA-sponsored research and development and related efforts are therefore required to publish the results of their work in the NASA STI series or through other externally accessible channels. An Agency-wide committee of publications professionals prepared the standards and conventions presented in this guide for authors. Section 2 of this guide presents descriptions of each type of report in the NASA STI Report Series and briefly discusses the applicable production methods and appropriate dissemination of these reports. Section 3 discusses professional and ethical concerns. Section 4 provides recommended standards for document format, makeup, and organization. Section 5 presents miscellaneous preparation concerns.

  11. Testing of a 4 K to 2 K heat exchanger with an intermediate pressure drop

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Knudsen, Peter N.; Ganni, Venkatarao

    2015-12-01

    Most large sub-atmospheric helium refrigeration systems incorporate a heat exchanger at the load, or in the distribution system, to counter-flow the sub-atmospheric return with the super-critical or liquid supply. A significant process improvement is theoretically obtainable by handling the exergy loss across the Joule-Thompson throttling valve supplying the flow to the load in a simple but different manner. As briefly outlined in previous publications, the exergy loss can be minimized by allowing the supply flow pressure to decrease to a sub-atmospheric pressure concurrent with heat exchange flow from the load. One practical implementation is to sub-divide the supply flow pressuremore » drop between two heat exchanger sections, incorporating an intermediate pressure drop. Such a test is being performed at Jefferson Lab's Cryogenic Test Facility (CTF). This paper will briefly discuss the theory, practical implementation and test results and analysis obtained to date.« less

  12. Product Assurance for Spaceflight Hardware

    NASA Technical Reports Server (NTRS)

    Monroe, Mike

    1995-01-01

    This report contains information about the tasks I have completed and the valuable experience I have gained at NASA. The report is divided into two different sections followed by a program summary sheet. The first section describes the two reports I have completed for the Office of Mission Assurance (OMA). I describe the approach and the resources and facilities used to complete each report. The second section describes my experience working in the Receipt Inspection/Quality Assurance Lab (RI/QA). The first report described is a Product Assurance Plan for the Gas Permeable Polymer Materials (GPPM) mission. The purpose of the Product Assurance Plan is to define the various requirements which are to be met through completion of the GPPM mission. The GPPM experiment is a space payload which will be flown in the shuttle's SPACEHAB module. The experiment will use microgravity to enable production of complex polymeric gas permeable materials. The second report described in the first section is a Fracture Analysis for the Mir Environmental Effects Payload (MEEP). The Fracture Analysis report is a summary of the fracture control classifications for all structural elements of the MEEP. The MEEP hardware consists of four experiment carriers, each of which contains an experiment container holding a passive experiment. The MEEP hardware will be attached to the cargo bay of the space shuttle. It will be transferred by Extravehicular Activity and mounted on the Mir space station. The second section of this report describes my experiences in the RVQA lab. I listed the different equipment I used at the lab and their functions. I described the extensive inspection process that must be completed for spaceflight hardware. Included, at the end of this section, are pictures of most of the equipment used in the lab. There is a summary sheet located at the end of this report. It briefly describes the valuable experience I have gained at NASA this summer and what I will be able to take with me as I return to college. I briefly discuss the experiences I mentioned in the previous three paragraphs along with training classes I attended and courses I completed at the Learning Lab.

  13. 40 CFR 66.81 - Final action.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 15 2010-07-01 2010-07-01 false Final action. 66.81 Section 66.81... COLLECTION OF NONCOMPLIANCE PENALTIES BY EPA Final Action § 66.81 Final action. (a) A final Agency action... State action pursuant to part 67. (b) The actions listed in paragraph (a) of this section constitute...

  14. User's manual for three dimensional FDTD version D code for scattering from frequency-dependent dielectric and magnetic materials

    NASA Technical Reports Server (NTRS)

    Beggs, John H.; Luebbers, Raymond J.; Kunz, Karl S.

    1992-01-01

    The Penn State Finite Difference Time Domain Electromagnetic Scattering Code version D is a 3-D numerical electromagnetic scattering code based upon the finite difference time domain technique (FDTD). The manual provides a description of the code and corresponding results for several scattering problems. The manual is organized into 14 sections: introduction; description of the FDTD method; operation; resource requirements; version D code capabilities; a brief description of the default scattering geometry; a brief description of each subroutine; a description of the include file; a section briefly discussing Radar Cross Section computations; a section discussing some scattering results; a sample problem setup section; a new problem checklist; references and figure titles. The FDTD technique models transient electromagnetic scattering and interactions with objects of arbitrary shape and/or material composition. In the FDTD method, Maxwell's curl equations are discretized in time-space and all derivatives (temporal and spatial) are approximated by central differences.

  15. MX Siting Investigation Geotechnical Evaluation. Volume IA. Nevada-Utah Verification Studies, FY 79.

    DTIC Science & Technology

    1979-08-24

    JUSTIFICATION E ECTE DISTRIUrION, D AVAILABILITY CODES DIST AVAIL AND/OR SPECIAL DATE ACCESSIONED 11 * Original contains color plates: All DTIC reproduct- IA...White River North, Garden- Coal , Reveille-Railroad and Big Smoky CDPs. Section 11.0 briefly explains previous work performed in Dry Lake and Ralston...Hamlin CDP Volume V - White River North CDP Volume VI - Garden- Coal CDP Volume VII - Reveille-Railroad CDP Volume VIII - Big Smoky CDP Volume IX - Dry

  16. MCNP/X TRANSPORT IN THE TABULAR REGIME

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    HUGHES, H. GRADY

    2007-01-08

    The authors review the transport capabilities of the MCNP and MCNPX Monte Carlo codes in the energy regimes in which tabular transport data are available. Giving special attention to neutron tables, they emphasize the measures taken to improve the treatment of a variety of difficult aspects of the transport problem, including unresolved resonances, thermal issues, and the availability of suitable cross sections sets. They also briefly touch on the current situation in regard to photon, electron, and proton transport tables.

  17. Qualitative model-based diagnosis using possibility theory

    NASA Technical Reports Server (NTRS)

    Joslyn, Cliff

    1994-01-01

    The potential for the use of possibility in the qualitative model-based diagnosis of spacecraft systems is described. The first sections of the paper briefly introduce the Model-Based Diagnostic (MBD) approach to spacecraft fault diagnosis; Qualitative Modeling (QM) methodologies; and the concepts of possibilistic modeling in the context of Generalized Information Theory (GIT). Then the necessary conditions for the applicability of possibilistic methods to qualitative MBD, and a number of potential directions for such an application, are described.

  18. The Design of Low-Turbulence Wind Tunnels

    NASA Technical Reports Server (NTRS)

    Dryden, Hugh L; Abbott, Ira H

    1949-01-01

    Within the past 10 years there have been placed in operation in the United States four low-turbulence wind tunnels of moderate cross-sectional area and speed, one at the National Bureau of Standards, two at the NACA Langley Laboratory, and one at the NACA Ames Laboratory. This paper reviews briefly the state of knowledge and those features which make possible the attainment of low turbulence in wind tunnels. Specific applications to two wind tunnels are described.

  19. Stochastic Lanchester-type Combat Models I.

    DTIC Science & Technology

    1979-10-01

    necessarily hold when the attrition rates become non- linear in b and/or r. 13 iL 4. OTHER COMBAT MODELS In this section we briefly describe how other...AD-A092 898 FLORIDA STATE UNIV TALLAHASSEE DEPT OF STATISTICS F/6 12/2 STOCHASTIC LANCHESTER-TYPE COMBAT MODELS I.(U) OCT 79 L BILLARD N62271-79-M...COMBAT MODELS I by L. BILLARD October 1979 Approved for public release; distribution unlimited. Prepared for: Naval Postgraduate School Monterey, CA 93940

  20. Creating Cultural Hybridity by Exporting Metropolitan Structures and Cultures of Schooling and Educationalisation? The Emergence of a Congolese "Elite" in the 1950s as a Starting Point for Further Research

    ERIC Educational Resources Information Center

    DePapae, Marc; Hulstaert, Karen

    2013-01-01

    This article consists of five sections. First, it briefly describes the results of the authors' previous studies on the history of colonial education in view of the problem introduced by the special issue of which this article is a part. Second, it links these results to such central concepts as the so-called grammars of schooling and…

  1. Thermophysical and tribological properties of nanolubricants: A review

    NASA Astrophysics Data System (ADS)

    Kotia, Ankit; Rajkhowa, Pranami; Rao, Gogineni Satyanarayana; Ghosh, Subrata Kumar

    2018-05-01

    Recent studies in heat transfer evident that the nanofluid shows better heat transfer results as compared to base fluid. This influences the research community for the dispersion of nanoparticles in lubricants to enhance its thermophysical and tribological properties and these suspensions are termed as Nanolubricants. This review focuses on the effect of nanoparticle additives on thermophysical and tribological properties of base lubricant. Initial section briefly summarizes the variation in thermophysical properties namely viscosity, thermal conductivity, density and specific heat of nanolubricants. In later section, the coefficient of friction and anti-wear properties of nanolubricants are summarized. This review along with the replenishment of current knowledge, also discusses the fundamental mechanisms that evolve with the dispersion of nanoparticles.

  2. Tax treatment of cafeteria plans. Internal Revenue Service (IRS), Treasury. Final regulations.

    PubMed

    2000-03-23

    This document contains final regulations relating to section 125 cafeteria plans. The final regulations clarify the circumstances under which a section 125 cafeteria plan election may be changed. The final regulations permit an employer to allow a section 125 cafeteria plan participant to revoke an existing election and make a new election during a period of coverage for accident or health coverage or group-term life insurance coverage.

  3. Vitreous floaters.

    PubMed

    Roufail, E D; Polkinghorne, Philip

    2006-01-01

    Floaters are a common presenting ophthalmic symptom that may accompany sight-threatening disorders. In most cases, they are often secondary to benign, degenerative changes in the vitreous. In this review, we briefly examine the anatomy of the vitreous and describe how degenerative vitreous change contributes to the development of floaters. The causality of floaters in the presence and absence of a posterior vitreous detachment is reviewed, as is the clinical significance of these symptoms and signs in relation to their predictive value for determining the presence of sight-threatening retinal tears and/or detachment. Finally, a brief review of management options for debilitating floaters is presented.

  4. Electromagnetic fields and their impacts

    NASA Astrophysics Data System (ADS)

    Prša, M. A.; Kasaš-Lažetić, K. K.

    2018-01-01

    The main goal of this paper is to briefly recall some different electromagnetic field definitions, some macroscopic sources of electromagnetic fields, electromagnetic fields classification regarding time dependences, and the ways of field determination in concrete cases. After that, all the mechanisms of interaction between electromagnetic field and substance, on atomic level, are described in details. Interaction between substance and electric field is investigated separately from the substance and magnetic field interaction. It is demonstrated that, in all cases of the unique electromagnetic field, total interaction can be treated as a superposition of two separated interactions. Finally, the main electromagnetic fields surrounding us is cited and discussed.

  5. Synthesis and size classification of metal oxide nanoparticles for biomedical applications

    NASA Astrophysics Data System (ADS)

    Atsumi, Takashi; Jeyadevan, Balachandran; Sato, Yoshinori; Tamura, Kazuchika; Aiba, Setsuya; Tohji, Kazuyuki

    2004-12-01

    Magnetic nanoparticles are considered for biomedical applications, such as the medium in magnetic resonance imaging, hyperthermia, drug delivery, and for the purification or classification of DNA or virus. The performance of magnetic nanoparticles in biomedical application such as hyperthermia depends very much on the magnetic properties, size and size distribution. We briefly described the basic idea behind their use in drug delivery, magnetic separation and hyperthermia and discussed the prerequisite properties magnetic particles for biomedical applications. Finally reported the synthesis and classification scheme to prepare magnetite (Fe3O4) nanoparticles with narrow size distribution for magnetic fluid hyperthermia.

  6. Brain Imaging, Forward Inference, and Theories of Reasoning

    PubMed Central

    Heit, Evan

    2015-01-01

    This review focuses on the issue of how neuroimaging studies address theoretical accounts of reasoning, through the lens of the method of forward inference (Henson, 2005, 2006). After theories of deductive and inductive reasoning are briefly presented, the method of forward inference for distinguishing between psychological theories based on brain imaging evidence is critically reviewed. Brain imaging studies of reasoning, comparing deductive and inductive arguments, comparing meaningful versus non-meaningful material, investigating hemispheric localization, and comparing conditional and relational arguments, are assessed in light of the method of forward inference. Finally, conclusions are drawn with regard to future research opportunities. PMID:25620926

  7. [Jaundice and pathological liver values].

    PubMed

    Schwarzenbach, Hans-Rudolf

    2013-06-05

    Jaundice corresponds to elevated bilirubin- levels, whereat one has to distinguish between direct and indirect serum-bilirubin. In the present Mini Review causes and differential diagnosis of jaundice are outlined. Ultrasound-diagnostic plays a major role in identifying intrahepatic or extrahepatic jaundice. Attention is given to the differential diagnosis of elevated liver enzymes in presence of jaundice, pointing out the distinction between hepatocellular and cholestatic parameters as well as the differentiation in acute or chronic increase. Moreover, the consequences of liver enzyme elevations including further diagnostic procedures, are highlighted. Finally, possibilities and limitations of modern diagnostic tests for liver fibrosis are briefly overviewed.

  8. Land use impacts of rapid transit: implications of recent experience. Final report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Knight, R.L.; Trygg, L.L.

    Evidence of land use impacts of recent major rapid transit improvements are reviewed and conclusions drawn concerning the extent and nature of such impacts and the conditions under which they have occurred. Transit improvements studied are primarily post-World War II in origin. American and Canadian examples are stressed, although European experience is teated briefly. Virtually all major modern American and Canadian rapid transit investments are included, covering conventional rapid rail, commuter rail, light rail and bus/busway. In addition to conclusions on general patterns of land use impact and causes, research recommendations and Federal policy implications are drawn.

  9. Reading, readability, and legibility research: implications for notification letters.

    PubMed

    Zimmerman, D E

    1993-01-01

    This article defines communication science and then briefly describes three research areas relevant to worker notifications: (1) receiving of notification messages, (2) reading and understanding of notification messages, and (3) influences or effects of notification messages on workers. Next, the article focuses on the reading and legibility research relevant to worker notifications and then provides 16 guidelines for drafting worker notifications. Finally, the article suggests evaluating draft notifications by using one or more of the following: skilled editorial reviews, readability scoring, Cloze techniques, signal stopping techniques, in-depth personal interviews, focus groups, and usability testing.

  10. Polymer-drug conjugates: origins, progress to date and future directions.

    PubMed

    Kopeček, Jindřich

    2013-01-01

    This overview focuses on bioconjugates of water-soluble polymers with low molecular weight drugs and proteins. After a short discussion of the origins of the field, the state-of-the-art is reviewed. Then research directions needed for the acceleration of the translation of nanomedicines into the clinic are outlined. Two most important directions, synthesis of backbone degradable polymer carriers and drug-free macromolecular therapeutics, a new paradigm in drug delivery, are discussed in detail. Finally, the future perspectives of the field are briefly discussed. Copyright © 2012 Elsevier B.V. All rights reserved.

  11. Ejected particle size measurement using Mie scattering in high explosive driven shockwave experiments

    DOE PAGES

    Monfared, Shabnam Khalighi; Buttler, William Tillman; Frayer, Daniel K.; ...

    2015-06-11

    In this paper, we report on the development of a diagnostic to provide constraints on the size of particles ejected from shocked metallic surfaces. The diagnostic is based on measurements of the intensity of laser light transmitted through a cloud of ejected particles as well as the angular distribution of scattered light, and the analysis of the resulting data is done using the Mie solution. Finally, we describe static experiments to test our experimental apparatus and present initial results of dynamic experiments on Sn targets. Improvements for future experiments are briefly discussed.

  12. Hidden Symmetries of Euclideanised Kerr-NUT-(A)dS Metrics in Certain Scaling Limits

    NASA Astrophysics Data System (ADS)

    Visinescu, Mihai; Vîlcu, Eduard

    2012-08-01

    The hidden symmetries of higher dimensional Kerr-NUT-(A)dS metrics are investigated. In certain scaling limits these metrics are related to the Einstein-Sasaki ones. The complete set of Killing-Yano tensors of the Einstein-Sasaki spaces are presented. For this purpose the Killing forms of the Calabi-Yau cone over the Einstein-Sasaki manifold are constructed. Two new Killing forms on Einstein-Sasaki manifolds are identified associated with the complex volume form of the cone manifolds. Finally the Killing forms on mixed 3-Sasaki manifolds are briefly described.

  13. Medicine as a profession.

    PubMed

    Funder, John W

    2010-06-01

    Over half a century ago, a Canadian judge defined a profession in a way that resonates still today, not only for lawyers and doctors, but for the current wide variety of professions and professionals. This article is a reflection on this definition. It briefly considers the historical context within which the knowledge base that characterises a profession evolved and what the various component parts of the judge's definition entail. A final consideration goes beyond the terms of the definition proposed--that of our ethical responsibility as professionals to stand up and be counted and, in the context of the disorder around us, to speak out.

  14. A dual process model of perfectionism based on reinforcement theory.

    PubMed

    Slade, P D; Owens, R G

    1998-07-01

    This article begins with a brief review of the current literature on the structure and measurement of perfectionism. It is concluded from this review that two major types can be distinguished, a normal/healthy form and a pathological form. These two forms are then defined as positive and negative perfectionism and related directly to Skinnerian concepts of positive and negative reinforcement. The positive/negative distinction is then further elaborated on in terms of approach/avoidance behavior, goal differences, self-concept involvement, emotional correlates, and the promoting environment. Finally, some of the more obvious theoretical and practical implications are briefly explored.

  15. Bistatic passive radar simulator with spatial filtering subsystem

    NASA Astrophysics Data System (ADS)

    Hossa, Robert; Szlachetko, Boguslaw; Lewandowski, Andrzej; Górski, Maksymilian

    2009-06-01

    The purpose of this paper is to briefly introduce the structure and features of the developed virtual passive FM radar implemented in Matlab system of numerical computations and to present many alternative ways of its performance. An idea of the proposed solution is based on analytic representation of transmitted direct signals and reflected echo signals. As a spatial filtering subsystem a beamforming network of ULA and UCA dipole configuration dedicated to bistatic radar concept is considered and computationally efficient procedures are presented in details. Finally, exemplary results of the computer simulations of the elaborated virtual simulator are provided and discussed.

  16. UV radiation in the melanoma capital of the world: What makes New Zealand so different?

    NASA Astrophysics Data System (ADS)

    McKenzie, Richard

    2017-02-01

    To better understand New Zealand's high rates of skin cancer, the UV climate of New Zealand is discussed in relation to other locations, and the factors contributing to geographical differences in UV are explored. Historical and projected future changes in UV are discussed in the context of what would have happened without implementation of the Montreal Protocol to protect the ozone layer. The effects of interactions due to future climate change are also discussed. Finally, the effects of our unique UV climate on human health are discussed briefly; along with changing public advice.

  17. Applications of Infrared and Raman Spectroscopies to Probiotic Investigation

    PubMed Central

    Santos, Mauricio I.; Gerbino, Esteban; Tymczyszyn, Elizabeth; Gomez-Zavaglia, Andrea

    2015-01-01

    In this review, we overview the most important contributions of vibrational spectroscopy based techniques in the study of probiotics and lactic acid bacteria. First, we briefly introduce the fundamentals of these techniques, together with the main multivariate analytical tools used for spectral interpretation. Then, four main groups of applications are reported: (a) bacterial taxonomy (Subsection 4.1); (b) bacterial preservation (Subsection 4.2); (c) monitoring processes involving lactic acid bacteria and probiotics (Subsection 4.3); (d) imaging-based applications (Subsection 4.4). A final conclusion, underlying the potentialities of these techniques, is presented. PMID:28231205

  18. Higher Order Heavy Quark Corrections to Deep-Inelastic Scattering

    NASA Astrophysics Data System (ADS)

    Blümlein, Johannes; DeFreitas, Abilio; Schneider, Carsten

    2015-04-01

    The 3-loop heavy flavor corrections to deep-inelastic scattering are essential for consistent next-to-next-to-leading order QCD analyses. We report on the present status of the calculation of these corrections at large virtualities Q2. We also describe a series of mathematical, computer-algebraic and combinatorial methods and special function spaces, needed to perform these calculations. Finally, we briefly discuss the status of measuring αs (MZ), the charm quark mass mc, and the parton distribution functions at next-to-next-to-leading order from the world precision data on deep-inelastic scattering.

  19. A relativistic analysis of clock synchronization

    NASA Technical Reports Server (NTRS)

    Thomas, J. B.

    1974-01-01

    The relativistic conversion between coordinate time and atomic time is reformulated to allow simpler time calculations relating analysis in solar-system barycentric coordinates (using coordinate time) with earth-fixed observations (measuring earth-bound proper time or atomic time.) After an interpretation of terms, this simplified formulation, which has a rate accuracy of about 10 to the minus 15th power, is used to explain the conventions required in the synchronization of a world wide clock network and to analyze two synchronization techniques-portable clocks and radio interferometry. Finally, pertinent experiment tests of relativity are briefly discussed in terms of the reformulated time conversion.

  20. Optical Fiber Networks for Remote Fiber Optic Sensors

    PubMed Central

    Fernandez-Vallejo, Montserrat; Lopez-Amo, Manuel

    2012-01-01

    This paper presents an overview of optical fiber sensor networks for remote sensing. Firstly, the state of the art of remote fiber sensor systems has been considered. We have summarized the great evolution of these systems in recent years; this progress confirms that fiber-optic remote sensing is a promising technology with a wide field of practical applications. Afterwards, the most representative remote fiber-optic sensor systems are briefly explained, discussing their schemes, challenges, pros and cons. Finally, a synopsis of the main factors to take into consideration in the design of a remote sensor system is gathered. PMID:22666011

  1. Supporting Solar Physics Research via Data Mining

    NASA Astrophysics Data System (ADS)

    Angryk, Rafal; Banda, J.; Schuh, M.; Ganesan Pillai, K.; Tosun, H.; Martens, P.

    2012-05-01

    In this talk we will briefly introduce three pillars of data mining (i.e. frequent patterns discovery, classification, and clustering), and discuss some possible applications of known data mining techniques which can directly benefit solar physics research. In particular, we plan to demonstrate applicability of frequent patterns discovery methods for the verification of hypotheses about co-occurrence (in space and time) of filaments and sigmoids. We will also show how classification/machine learning algorithms can be utilized to verify human-created software modules to discover individual types of solar phenomena. Finally, we will discuss applicability of clustering techniques to image data processing.

  2. Cheating and sports: history, diagnosis and treatment.

    PubMed

    Kamis, Danielle; Newmark, Thomas; Begel, Daniel; Glick, Ira D

    2016-12-01

    This paper focuses on "cheating" in modern day athletics from youth through professional sports. We briefly summarize a history of cheating in the sports world. We examine the current role cheating plays in sports as well as its causes including, psychodynamic issues, the development of personality disorders and how personality traits become pathological resulting in deception, dishonesty, and underhandedness. We describe management and treatment including psychotherapeutic intervention as well as medication. Finally we discuss a systems approach involving outreach to coaches, families, and related sports organizations (like FIFA, WADA, etc) or the professional leagues which have institutional control and partial influence on the athlete.

  3. Charmless and Penguin Decays at CDF

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dorigo, Mirco; Collaboration, for the CDF

    2010-12-01

    Penguin transitions play a key role in the search of New Physics hints in the heavy flavor sector. During the last decade CDF has been exploring this opportunity with a rich study of two-body charmless decays of neutral B mesons into charged final-state particles. After briefly introducing the aspects of this physics peculiar to the hadron collision environment, I report on two interesting results: the first polarization measurement of the B{sub s}{sup 0} {yields} {phi}{phi} decay and the update of the B{sub (s)}{sup 0} {yields} h{sup +}h{prime}{sup -} decays analysis.

  4. Studies of Solar Wind Interaction and Ionospheric Processes at Venus and Mars

    NASA Technical Reports Server (NTRS)

    Bogan, Denis (Technical Monitor); Nagy, Andrew F.

    2003-01-01

    This is the final report summarizing the work done during the last three years under NASA Grant NAG5-8946. Our efforts centered on a systematic development of a new generation of three dimensional magneto-hydrodynamic (MHD) numerical code, which models the interaction processes of the solar wind or fast flowing magnetospheric plasma with 'non-magnetic' solar system bodies (e.g. Venus, Mars, Europa, Titan). We have also worked on a number of different, more specific and discrete studies, as various opportunities arose. In the next few pages we briefly summarize these efforts.

  5. Center for Plasma Edge Simulation (CPES) -- Rutgers University Final Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Parashar, Manish

    2014-03-06

    The CPES scientific simulations run at scale on leadership class machines, collaborate at runtime and produce and exchange large data sizes, which present multiple I/O and data management challenges. During the CPES project, the Rutgers team worked with the rest of the CPES team to address these challenges at different levels, and specifically (1) at the data transport and communication level through the DART (Decoupled and Asynchronous Remote Data Transfers) framework, and (2) at the data management and services level through the DataSpaces and ActiveSpaces frameworks. These frameworks and their impact are briefly described.

  6. Clostridium botulinum and the ophthalmologist: a review of botulism, including biological warfare ramifications of botulinum toxin.

    PubMed

    Caya, J G

    2001-01-01

    The anaerobic bacterium Clostridium botulinum causes disease by elaborating an extremely potent neurotoxin that inhibits release of acetylcholine at presynaptic nerve endings, thereby resulting in a descending flaccid paralysis and autonomic nervous system dysfunction. Possible ophthalmological effects of this neurotoxin are many and typically constitute the earliest manifestations of botulism. This review summarizes the medical literature on botulism with regard to historical perspective, epidemiology, clinical manifestations, and treatment. Ophthalmological findings of botulism are tabulated and their frequencies are provided. Finally, the bioterrorism/biologic warfare ramifications of botulinum toxin are briefly discussed.

  7. Computational methods for vortex dominated compressible flows

    NASA Technical Reports Server (NTRS)

    Murman, Earll M.

    1987-01-01

    The principal objectives were to: understand the mechanisms by which Euler equation computations model leading edge vortex flows; understand the vortical and shock wave structures that may exist for different wing shapes, angles of incidence, and Mach numbers; and compare calculations with experiments in order to ascertain the limitations and advantages of Euler equation models. The initial approach utilized the cell centered finite volume Jameson scheme. The final calculation utilized a cell vertex finite volume method on an unstructured grid. Both methods used Runge-Kutta four stage schemes for integrating the equations. The principal findings are briefly summarized.

  8. OVMS-plus at the LBT: disturbance compensation simplified

    NASA Astrophysics Data System (ADS)

    Böhm, Michael; Pott, Jörg-Uwe; Borelli, José; Hinz, Phil; Defrère, Denis; Downey, Elwood; Hill, John; Summers, Kellee; Conrad, Al; Kürster, Martin; Herbst, Tom; Sawodny, Oliver

    2016-07-01

    In this paper we will briefly revisit the optical vibration measurement system (OVMS) at the Large Binocular Telescope (LBT) and how these values are used for disturbance compensation and particularly for the LBT Interferometer (LBTI) and the LBT Interferometric Camera for Near-Infrared and Visible Adaptive Interferometry for Astronomy (LINC-NIRVANA). We present the now centralized software architecture, called OVMS+, on which our approach is based and illustrate several challenges faced during the implementation phase. Finally, we will present measurement results from LBTI proving the effectiveness of the approach and the ability to compensate for a large fraction of the telescope induced vibrations.

  9. Modeling and Properties of Nonlinear Stochastic Dynamical System of Continuous Culture

    NASA Astrophysics Data System (ADS)

    Wang, Lei; Feng, Enmin; Ye, Jianxiong; Xiu, Zhilong

    The stochastic counterpart to the deterministic description of continuous fermentation with ordinary differential equation is investigated in the process of glycerol bio-dissimilation to 1,3-propanediol by Klebsiella pneumoniae. We briefly discuss the continuous fermentation process driven by three-dimensional Brownian motion and Lipschitz coefficients, which is suitable for the factual fermentation. Subsequently, we study the existence and uniqueness of solutions for the stochastic system as well as the boundedness of the Two-order Moment and the Markov property of the solution. Finally stochastic simulation is carried out under the Stochastic Euler-Maruyama method.

  10. Clinical aspects of the fragile X syndrome.

    PubMed

    Brown, W Ted

    2012-01-01

    Fragile X syndrome patients express a wide array of cognitive and other gender-specific phenotypic features. These manifestations result not only from molecular mechanisms that are altered as a result of the expansion of a CGG-repeat region in the FMR1 promoter, but also genetic factors such as founder effects and mosaicism. In this chapter, I will summarize the many and varied features of fragile X syndrome as they present themselves in a clinical setting and describe the procedures that are used to diagnose patients. Finally, I will briefly touch on recent developments that will affect patient screening in the future.

  11. The Search for Neutrinos from Gamma Ray Bursts with AMANDA

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kuehn, Kyler

    2006-05-19

    We report on the combined analysis of over 400 GRB time periods that occurred during seven years of AMANDA observations. AMANDA has seen no neutrinos correlated with these bursts, thus we report a neutrino flux limit that is the most stringent observational limit to date. In light of the new observational opportunities afforded by Swift, we also discuss the future potential for GRB neutrino detection with AMANDA'S successor, IceCube. Finally, we briefly discuss the expansion of AMANDA'S transient point-source search to other phenomena, such as jet-driven supernovae and gamma-ray dark bursts.

  12. Research progress on catalytic denitrification technology in chemical industry

    NASA Astrophysics Data System (ADS)

    Jin, Yezhi

    2017-12-01

    In recent years, due to the rising emission of NOx annually, attention has been aroused widely by people on more and more severe environmental problems. This paper first discusses applying NOx removal and control technologies and relating chemical principles. Of many technologies, selective reduction reaction (SCR) is the most widely used. Catalysts, the concentration of NOx at the entrance of SCR catalytic reactor, reaction temperature, NH3/NOx mole ratio and NH3 slip rate analyzed later contributes to the removal efficiency of NOx. Finally, the processing and configuration of SCR de-NOx system are briefly introduced.

  13. Brain imaging, forward inference, and theories of reasoning.

    PubMed

    Heit, Evan

    2014-01-01

    This review focuses on the issue of how neuroimaging studies address theoretical accounts of reasoning, through the lens of the method of forward inference (Henson, 2005, 2006). After theories of deductive and inductive reasoning are briefly presented, the method of forward inference for distinguishing between psychological theories based on brain imaging evidence is critically reviewed. Brain imaging studies of reasoning, comparing deductive and inductive arguments, comparing meaningful versus non-meaningful material, investigating hemispheric localization, and comparing conditional and relational arguments, are assessed in light of the method of forward inference. Finally, conclusions are drawn with regard to future research opportunities.

  14. The controlled preparation of polypyrrole nanostructures via tuning the concentration of acrylic acid.

    PubMed

    Wang, Yujie; Zhong, Wenbin; Ning, Xutao; Li, Yuntao; Chen, Xiaohua; Wang, Yongxin; Yang, Wantai

    2013-03-01

    Two types of nanostructures, nanowires and nanoribbons were prepared with polypyrrole (PPy) by controlling the concentration of acrylic acid (AA) in systems containing cationic surfactant, cetyltrimethylammonium bromide (CTAB) at about 12 degrees C. The effect of reaction conditions involving the concentration of AA, CTAB, pyrrole as well as the reaction temperature was systematically studied on the final structures of prepared PPy. The results revealed that the polymerization of AA, resulting in PAA, played a key role in the evolution of PPy nanostructures. A possible mechanism was briefly discussed on the formation of these two nanostructures, nanowires and nanoribbons.

  15. DNA origami nanopores: developments, challenges and perspectives

    NASA Astrophysics Data System (ADS)

    Hernández-Ainsa, Silvia; Keyser, Ulrich F.

    2014-11-01

    DNA nanotechnology has enabled the construction of DNA origami nanopores; synthetic nanopores that present improved capabilities for the area of single molecule detection. Their extraordinary versatility makes them a new and powerful tool in nanobiotechnology for a wide range of important applications beyond molecular sensing. In this review, we briefly present the recent developments in this emerging field of research. We discuss the current challenges and possible solutions that would enhance the sensing capabilities of DNA origami nanopores. Finally, we anticipate novel avenues for future research and highlight a range of exciting ideas and applications that could be explored in the near future.

  16. The Detection Of Neutrino Interactions In The OPERA Experiment: An Update

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Patrizii, Laura

    2009-12-17

    OPERA is a long baseline neutrino oscillation experiment built to provide the final and unambiguous proof of the neutrino oscillation hypothesis in the atmospheric sector by observing {nu}{sub {tau}} emerging from the CNGS {nu}{sub {mu}} beam. The detector is a hybrid apparatus installed in the Hall C of the underground Gran Sasso National Laboratory in Italy. Runs with CNGS neutrinos were successfully carried out in 2007 and 2008. In this paper the detector and the analysis strategy are briefly described and the status of the analysis of the 2008 run events is discussed.

  17. Genetically encoded Ca2+ indicators: using genetics and molecular design to understand complex physiology

    PubMed Central

    Kotlikoff, Michael I

    2007-01-01

    This article reviews genetically encoded Ca2+ indicators (GECIs), with a focus on the use of these novel molecules in the context of understanding complex cell signalling in mammals, in vivo. The review focuses on the advantages and limitations of specific GECI design strategies and the results of experiments in which these molecules have been expressed in transgenic mice, concentrating particularly on recent experiments from our laboratory in which physiological signalling could be monitored in vivo. Finally, newer strategies for effective genetic specification of GECIs are briefly reviewed. PMID:17038427

  18. 31 CFR 800.601 - Finality of actions under section 721.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (Continued) OFFICE OF INVESTMENT SECURITY, DEPARTMENT OF THE TREASURY REGULATIONS PERTAINING TO MERGERS, ACQUISITIONS, AND TAKEOVERS BY FOREIGN PERSONS Finality of Action § 800.601 Finality of actions under section...

  19. Liposomes as nanomedical devices

    PubMed Central

    Bozzuto, Giuseppina; Molinari, Agnese

    2015-01-01

    Since their discovery in the 1960s, liposomes have been studied in depth, and they continue to constitute a field of intense research. Liposomes are valued for their biological and technological advantages, and are considered to be the most successful drug-carrier system known to date. Notable progress has been made, and several biomedical applications of liposomes are either in clinical trials, are about to be put on the market, or have already been approved for public use. In this review, we briefly analyze how the efficacy of liposomes depends on the nature of their components and their size, surface charge, and lipidic organization. Moreover, we discuss the influence of the physicochemical properties of liposomes on their interaction with cells, half-life, ability to enter tissues, and final fate in vivo. Finally, we describe some strategies developed to overcome limitations of the “first-generation” liposomes, and liposome-based drugs on the market and in clinical trials. PMID:25678787

  20. Monkey cortex through fMRI glasses

    PubMed Central

    Vanduffel, Wim; Zhu, Qi; Orban, Guy A.

    2015-01-01

    In 1998 several groups reported the feasibility of functional magnetic resonance imaging (fMRI) experiments in monkeys, with the goal to bridge the gap between invasive nonhuman primate studies and human functional imaging. These studies yielded critical insights in the neuronal underpinnings of the BOLD signal. Furthermore, the technology has been successful in guiding electrophysiological recordings and identifying focal perturbation targets. Finally, invaluable information was obtained concerning human brain evolution. We here provide a comprehensive overview of awake monkey fMRI studies mainly confined to the visual system. We review the latest insights about the topographic organization of monkey visual cortex and discuss the spatial relationships between retinotopy and category and feature selective clusters. We briefly discuss the functional layout of parietal and frontal cortex and continue with a summary of some fascinating functional and effective connectivity studies. Finally, we review recent comparative fMRI experiments and speculate about the future of nonhuman primate imaging. PMID:25102559

Top