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Sample records for finding srna generative

  1. A Novel Mechanism of Host-Pathogen Interaction through sRNA in Bacterial Outer Membrane Vesicles

    PubMed Central

    Koeppen, Katja; Hampton, Thomas H.; Jarek, Michael; Scharfe, Maren; Gerber, Scott A.; Mielcarz, Daniel W.; Demers, Elora G.; Dolben, Emily L.; Hammond, John H.; Hogan, Deborah A.; Stanton, Bruce A.

    2016-01-01

    Bacterial outer membrane vesicle (OMV)-mediated delivery of proteins to host cells is an important mechanism of host-pathogen communication. Emerging evidence suggests that OMVs contain differentially packaged short RNAs (sRNAs) with the potential to target host mRNA function and/or stability. In this study, we used RNA-Seq to characterize differentially packaged sRNAs in Pseudomonas aeruginosa OMVs, and to show transfer of OMV sRNAs to human airway cells. We selected one sRNA for further study based on its stable secondary structure and predicted mRNA targets. Our candidate sRNA (sRNA52320), a fragment of a P. aeruginosa methionine tRNA, was abundant in OMVs and reduced LPS-induced as well as OMV-induced IL-8 secretion by cultured primary human airway epithelial cells. We also showed that sRNA52320 attenuated OMV-induced KC cytokine secretion and neutrophil infiltration in mouse lung. Collectively, these findings are consistent with the hypothesis that sRNA52320 in OMVs is a novel mechanism of host-pathogen interaction whereby P. aeruginosa reduces the host immune response. PMID:27295279

  2. Novel small RNA (sRNA) landscape of the starvation-stress response transcriptome of Salmonella enterica serovar typhimurium.

    PubMed

    Amin, Shivam V; Roberts, Justin T; Patterson, Dillon G; Coley, Alexander B; Allred, Jonathan A; Denner, Jason M; Johnson, Justin P; Mullen, Genevieve E; O'Neal, Trenton K; Smith, Jason T; Cardin, Sara E; Carr, Hank T; Carr, Stacie L; Cowart, Holly E; DaCosta, David H; Herring, Brendon R; King, Valeria M; Polska, Caroline J; Ward, Erin E; Wise, Alice A; McAllister, Kathleen N; Chevalier, David; Spector, Michael P; Borchert, Glen M

    2016-01-01

    Small RNAs (sRNAs) are short (∼50-200 nucleotides) noncoding RNAs that regulate cellular activities across bacteria. Salmonella enterica starved of a carbon-energy (C) source experience a host of genetic and physiological changes broadly referred to as the starvation-stress response (SSR). In an attempt to identify novel sRNAs contributing to SSR control, we grew log-phase, 5-h C-starved and 24-h C-starved cultures of the virulent Salmonella enterica subspecies enterica serovar Typhimurium strain SL1344 and comprehensively sequenced their small RNA transcriptomes. Strikingly, after employing a novel strategy for sRNA discovery based on identifying dynamic transcripts arising from "gene-empty" regions, we identify 58 wholly undescribed Salmonella sRNA genes potentially regulating SSR averaging an ∼1,000-fold change in expression between log-phase and C-starved cells. Importantly, the expressions of individual sRNA loci were confirmed by both comprehensive transcriptome analyses and northern blotting of select candidates. Of note, we find 43 candidate sRNAs share significant sequence identity to characterized sRNAs in other bacteria, and ∼70% of our sRNAs likely assume characteristic sRNA structural conformations. In addition, we find 53 of our 58 candidate sRNAs either overlap neighboring mRNA loci or share significant sequence complementarity to mRNAs transcribed elsewhere in the SL1344 genome strongly suggesting they regulate the expression of transcripts via antisense base-pairing. Finally, in addition to this work resulting in the identification of 58 entirely novel Salmonella enterica genes likely participating in the SSR, we also find evidence suggesting that sRNAs are significantly more prevalent than currently appreciated and that Salmonella sRNAs may actually number in the thousands.

  3. Phage-mediated Delivery of Targeted sRNA Constructs to Knock Down Gene Expression in E. coli.

    PubMed

    Bernheim, Aude G; Libis, Vincent K; Lindner, Ariel B; Wintermute, Edwin H

    2016-01-01

    RNA-mediated knockdowns are widely used to control gene expression. This versatile family of techniques makes use of short RNA (sRNA) that can be synthesized with any sequence and designed to complement any gene targeted for silencing. Because sRNA constructs can be introduced to many cell types directly or using a variety of vectors, gene expression can be repressed in living cells without laborious genetic modification. The most common RNA knockdown technology, RNA interference (RNAi), makes use of the endogenous RNA-induced silencing complex (RISC) to mediate sequence recognition and cleavage of the target mRNA. Applications of this technique are therefore limited to RISC-expressing organisms, primarily eukaryotes. Recently, a new generation of RNA biotechnologists have developed alternative mechanisms for controlling gene expression through RNA, and so made possible RNA-mediated gene knockdowns in bacteria. Here we describe a method for silencing gene expression in E. coli that functionally resembles RNAi. In this system a synthetic phagemid is designed to express sRNA, which may designed to target any sequence. The expression construct is delivered to a population of E. coli cells with non-lytic M13 phage, after which it is able to stably replicate as a plasmid. Antisense recognition and silencing of the target mRNA is mediated by the Hfq protein, endogenous to E. coli. This protocol includes methods for designing the antisense sRNA, constructing the phagemid vector, packaging the phagemid into M13 bacteriophage, preparing a live cell population for infection, and performing the infection itself. The fluorescent protein mKate2 and the antibiotic resistance gene chloramphenicol acetyltransferase (CAT) are targeted to generate representative data and to quantify knockdown effectiveness. PMID:27023729

  4. Phage-mediated Delivery of Targeted sRNA Constructs to Knock Down Gene Expression in E. coli

    PubMed Central

    Lindner, Ariel B.; Wintermute, Edwin H.

    2016-01-01

    RNA-mediated knockdowns are widely used to control gene expression. This versatile family of techniques makes use of short RNA (sRNA) that can be synthesized with any sequence and designed to complement any gene targeted for silencing. Because sRNA constructs can be introduced to many cell types directly or using a variety of vectors, gene expression can be repressed in living cells without laborious genetic modification. The most common RNA knockdown technology, RNA interference (RNAi), makes use of the endogenous RNA-induced silencing complex (RISC) to mediate sequence recognition and cleavage of the target mRNA. Applications of this technique are therefore limited to RISC-expressing organisms, primarily eukaryotes. Recently, a new generation of RNA biotechnologists have developed alternative mechanisms for controlling gene expression through RNA, and so made possible RNA-mediated gene knockdowns in bacteria. Here we describe a method for silencing gene expression in E. coli that functionally resembles RNAi. In this system a synthetic phagemid is designed to express sRNA, which may designed to target any sequence. The expression construct is delivered to a population of E. coli cells with non-lytic M13 phage, after which it is able to stably replicate as a plasmid. Antisense recognition and silencing of the target mRNA is mediated by the Hfq protein, endogenous to E. coli. This protocol includes methods for designing the antisense sRNA, constructing the phagemid vector, packaging the phagemid into M13 bacteriophage, preparing a live cell population for infection, and performing the infection itself. The fluorescent protein mKate2 and the antibiotic resistance gene chloramphenicol acetyltransferase (CAT) are targeted to generate representative data and to quantify knockdown effectiveness. PMID:27023729

  5. MicA sRNA links the PhoP regulon to cell envelope stress

    PubMed Central

    Coornaert, Audrey; Lu, Alisa; Mandin, Pierre; Springer, Mathias; Gottesman, Susan; Guillier, Maude

    2010-01-01

    Numerous small RNAs regulators of gene expression exist in bacteria. A large class of them binds to the RNA chaperone Hfq and act by base-pairing interactions with their target-mRNA, thereby affecting their translation and/or stability. They often have multiple direct targets, some of which may be regulators themselves, and production of a single sRNA can therefore affect the expression of dozens of genes. We show in this study that the synthesis of the E. coli pleiotropic PhoPQ two-component system is repressed by MicA, a σE-dependent sRNA regulator of porin biogenesis. MicA directly pairs with phoPQ mRNA in the translation initiation region of phoP and presumably inhibits translation by competiting with ribosome binding. Consequently, MicA down-regulates several members of the PhoPQ regulon. By linking PhoPQ to σE, our findings suggest that major cellular processes such as Mg2+ transport, virulence, LPS modification or resistance to antimicrobial peptides are modulated in response to envelope stress. In addition, we found that Hfq strongly affects the expression of phoP independently of MicA, raising the possibility that even more sRNAs, that remain to be identified, could regulate PhoPQ synthesis. PMID:20345657

  6. Finding the best portable congruential random number generators

    NASA Astrophysics Data System (ADS)

    Sezgin, Fatin; Sezgin, Tevfik Metin

    2013-08-01

    Linear congruential random number generators must have large moduli to attain maximum periods, but this creates integer overflow during calculations. Several methods have been suggested to remedy this problem while obtaining portability. Approximate factoring is the most common method in portable implementations, but there is no systematic technique for finding appropriate multipliers and an exhaustive search is prohibitively expensive. We offer a very efficient method for finding all portable multipliers of any given modulus value. Letting M=AB+C, the multiplier A gives a portable result if B-C is positive. If it is negative, the portable multiplier can be defined as A=⌊M/B⌋. We also suggest a method for discovering the most fertile search region for spectral top-quality multipliers in a two-dimensional space. The method is extremely promising for best generator searches in very large moduli: 64-bit sizes and above. As an application to an important and challenging problem, we examined the prime modulus 263-25, suitable for 64-bit register size, and determined 12 high quality portable generators successfully passing stringent spectral and empirical tests.

  7. A survey of sRNA families in α-proteobacteria

    PubMed Central

    del Val, Coral; Romero-Zaliz, Rocío; Torres-Quesada, Omar; Peregrina, Alexandra; Toro, Nicolás; Jiménez-Zurdo, Jose I

    2012-01-01

    We have performed a computational comparative analysis of six small non-coding RNA (sRNA) families in α-proteobacteria. Members of these families were first identified in the intergenic regions of the nitrogen-fixing endosymbiont S. meliloti by a combined bioinformatics screen followed by experimental verification. Consensus secondary structures inferred from covariance models for each sRNA family evidenced in some cases conserved motifs putatively relevant to the function of trans-encoded base-pairing sRNAs i.e., Hfq-binding signatures and exposed anti Shine-Dalgarno sequences. Two particular family models, namely αr15 and αr35, shared own sub-structural modules with the Rfam model suhB (RF00519) and the uncharacterized sRNA family αr35b, respectively. A third sRNA family, termed αr45, has homology to the cis-acting regulatory element speF (RF00518). However, new experimental data further confirmed that the S. meliloti αr45 representative is an Hfq-binding sRNA processed from or expressed independently of speF, thus refining the Rfam speF model annotation. All the six families have members in phylogenetically related plant-interacting bacteria and animal pathogens of the order of the Rhizobiales, some occurring with high levels of paralogy in individual genomes. In silico and experimental evidences predict differential regulation of paralogous sRNAs in S. meliloti 1021. The distribution patterns of these sRNA families suggest major contributions of vertical inheritance and extensive ancestral duplication events to the evolution of sRNAs in plant-interacting bacteria. PMID:22418845

  8. A survey of sRNA families in α-proteobacteria.

    PubMed

    del Val, Coral; Romero-Zaliz, Rocío; Torres-Quesada, Omar; Peregrina, Alexandra; Toro, Nicolás; Jiménez-Zurdo, Jose I

    2012-02-01

    We have performed a computational comparative analysis of six small non-coding RNA (sRNA) families in α-proteobacteria. Members of these families were first identified in the intergenic regions of the nitrogen-fixing endosymbiont S. meliloti by a combined bioinformatics screen followed by experimental verification. Consensus secondary structures inferred from covariance models for each sRNA family evidenced in some cases conserved motifs putatively relevant to the function of trans-encoded base-pairing sRNAs i.e., Hfq-binding signatures and exposed anti Shine-Dalgarno sequences. Two particular family models, namely αr15 and αr35, shared own sub-structural modules with the Rfam model suhB (RF00519) and the uncharacterized sRNA family αr35b, respectively. A third sRNA family, termed αr45, has homology to the cis-acting regulatory element speF (RF00518). However, new experimental data further confirmed that the S. meliloti αr45 representative is an Hfq-binding sRNA processed from or expressed independently of speF, thus refining the Rfam speF model annotation. All the six families have members in phylogenetically related plant-interacting bacteria and animal pathogens of the order of the Rhizobiales, some occurring with high levels of paralogy in individual genomes. In silico and experimental evidences predict differential regulation of paralogous sRNAs in S. meliloti 1021. The distribution patterns of these sRNA families suggest major contributions of vertical inheritance and extensive ancestral duplication events to the evolution of sRNAs in plant-interacting bacteria. PMID:22418845

  9. Identification of bacterial sRNA regulatory targets using ribosome profiling

    PubMed Central

    Wang, Jing; Rennie, William; Liu, Chaochun; Carmack, Charles S.; Prévost, Karine; Caron, Marie-Pier; Massé, Eric; Ding, Ye; Wade, Joseph T.

    2015-01-01

    Bacteria express large numbers of non-coding, regulatory RNAs known as ‘small RNAs’ (sRNAs). sRNAs typically regulate expression of multiple target messenger RNAs (mRNAs) through base-pairing interactions. sRNA:mRNA base-pairing often results in altered mRNA stability and/or altered translation initiation. Computational identification of sRNA targets is challenging due to the requirement for only short regions of base-pairing that can accommodate mismatches. Experimental approaches have been applied to identify sRNA targets on a genomic scale, but these focus only on those targets regulated at the level of mRNA stability. Here, we utilize ribosome profiling (Ribo-seq) to experimentally identify regulatory targets of the Escherichia coli sRNA RyhB. We not only validate a majority of known RyhB targets using the Ribo-seq approach, but also discover many novel ones. We further confirm regulation of a selection of known and novel targets using targeted reporter assays. By mutating nucleotides in the mRNA of a newly discovered target, we demonstrate direct regulation of this target by RyhB. Moreover, we show that Ribo-seq distinguishes between mRNAs regulated at the level of RNA stability and those regulated at the level of translation. Thus, Ribo-seq represents a powerful approach for genome-scale identification of sRNA targets. PMID:26546513

  10. Silver Birches: Finding Roots, Extending Branches into the Next Generation.

    ERIC Educational Resources Information Center

    Olmstead, Kathryn

    1995-01-01

    Between 1974 and 1981, 15 teenagers in northern Maine published a small magazine containing interviews with and photographs of their grandparents, aunts, uncles, and neighbors. At a 20-year reunion, they realized that they had collected that heritage not only for archival preservation but to carry it forward for the next generation. (TD)

  11. Genetic basis of sRNA quantitative variation analyzed using an experimental population derived from an elite rice hybrid

    PubMed Central

    Wang, Jia; Yao, Wen; Zhu, Dan; Xie, Weibo; Zhang, Qifa

    2015-01-01

    We performed a genetic analysis of sRNA abundance in flag leaf from an immortalized F2 (IMF2) population in rice. We identified 53,613,739 unique sRNAs and 165,797 sRNA expression traits (s-traits). A total of 66,649 s-traits mapped 40,049 local-sQTLs and 30,809 distant-sQTLs. By defining 80,362 sRNA clusters, 22,263 sRNA cluster QTLs (scQTLs) were recovered for 20,249 of all the 50,139 sRNA cluster expression traits (sc-traits). The expression levels for most of s-traits from the same genes or the same sRNA clusters were slightly positively correlated. While genetic co-regulation between sRNAs from the same mother genes and between sRNAs and their mother genes was observed for a portion of the sRNAs, most of the sRNAs and their mother genes showed little co-regulation. Some sRNA biogenesis genes were located in distant-sQTL hotspots and showed correspondence with specific length classes of sRNAs suggesting their important roles in the regulation and biogenesis of the sRNAs. DOI: http://dx.doi.org/10.7554/eLife.03913.001 PMID:25821986

  12. Genetic basis of sRNA quantitative variation analyzed using an experimental population derived from an elite rice hybrid.

    PubMed

    Wang, Jia; Yao, Wen; Zhu, Dan; Xie, Weibo; Zhang, Qifa

    2015-03-30

    We performed a genetic analysis of sRNA abundance in flag leaf from an immortalized F2 (IMF2) population in rice. We identified 53,613,739 unique sRNAs and 165,797 sRNA expression traits (s-traits). A total of 66,649 s-traits mapped 40,049 local-sQTLs and 30,809 distant-sQTLs. By defining 80,362 sRNA clusters, 22,263 sRNA cluster QTLs (scQTLs) were recovered for 20,249 of all the 50,139 sRNA cluster expression traits (sc-traits). The expression levels for most of s-traits from the same genes or the same sRNA clusters were slightly positively correlated. While genetic co-regulation between sRNAs from the same mother genes and between sRNAs and their mother genes was observed for a portion of the sRNAs, most of the sRNAs and their mother genes showed little co-regulation. Some sRNA biogenesis genes were located in distant-sQTL hotspots and showed correspondence with specific length classes of sRNAs suggesting their important roles in the regulation and biogenesis of the sRNAs.

  13. Hydropower generation and whitewater recreation: Finding the common ground

    SciTech Connect

    DiGennaro, B.; Kessler, J.

    1995-12-31

    Many hydropower projects are located (or are proposed for location) along rivers that either support or have the potential to support whitewater recreation. The issue of balancing hydropower operations with non power benefits such as whitewater recreation, has become more prevalent in the last few years due to the passage of the Electric Consumers Protection Act in 1986, and increased public demands for river-oriented recreation. Balancing potentially competing resource values has created a number of new challenges for the hydropower industry, the regulatory agencies, and the public. This paper will concentrate on one aspect of the balancing act - balancing power generation with downstream whitewater recreation. It will discuss specific issues and challenges and describe several examples where licensees and whitewater enthusiasts have worked together to identify specific needs, discover common ground, and develop sensible approaches to sharing the resource.

  14. Identification of metE as a Second Target of the sRNA scr5239 in Streptomyces coelicolor

    PubMed Central

    Vockenhuber, Michael-Paul; Heueis, Nona; Suess, Beatrix

    2015-01-01

    While transcriptional regulation of the primary and secondary metabolism of the model organism Streptomyces coelicolor is well studied, little is still known about the role small noncoding RNAs (sRNAs) play in regulating gene expression in this organism. Here, we report the identification of a second target of the sRNA scr5239, an sRNA highly conserved in streptomycetes. The 159 nt long sRNA binds its target, the mRNA of the cobalamin independent methionine synthase metE (SCO0985), at the 5’ end of its open reading frame thereby repressing translation. We show that a high methionine level induces expression of scr5239 itself. This leads, in a negative feedback loop, to the repression of methionine biosynthesis. In contrast to the first reported target of this sRNA, the agarase dagA, this interaction seems to be conserved in a wide number of streptomycetes. PMID:25785836

  15. RNomics in Escherichia coli detects new sRNA species and indicates parallel transcriptional output in bacteria

    PubMed Central

    Vogel, Jörg; Bartels, Verena; Tang, Thean Hock; Churakov, Gennady; Slagter-Jäger, Jacoba G.; Hüttenhofer, Alexander; Wagner, E. Gerhart H.

    2003-01-01

    Recent bioinformatics-aided searches have identified many new small RNAs (sRNAs) in the intergenic regions of the bacterium Escherichia coli. Here, a shot-gun cloning approach (RNomics) was used to generate cDNA libraries of small sized RNAs. Besides many of the known sRNAs, we found new species that were not predicted previously. The present work brings the number of sRNAs in E.coli to 62. Experimental transcription start site mapping showed that some sRNAs were encoded from independent genes, while others were processed from mRNA leaders or trailers, indicative of a parallel transcriptional output generating sRNAs co-expressed with mRNAs. Two of these RNAs (SroA and SroG) consist of known (THI and RFN) riboswitch elements. We also show that two recently identified sRNAs (RyeB and SraC/RyeA) interact, resulting in RNase III-dependent cleavage. To the best of our knowledge, this represents the first case of two non-coding RNAs interacting by a putative antisense mechanism. In addition, intracellular metabolic stabilities of sRNAs were determined, including ones from previous screens. The wide range of half-lives (<2 to >32 min) indicates that sRNAs cannot generally be assumed to be metabolically stable. The experimental characterization of sRNAs analyzed here suggests that the definition of an sRNA is more complex than previously assumed. PMID:14602901

  16. Findings

    MedlinePlus

    ... Issue All Issues Explore Findings by Topic Cell Biology Cellular Structures, Functions, Processes, Imaging, Stress Response Chemistry ... Glycobiology, Synthesis, Natural Products, Chemical Reactions Computers in Biology Bioinformatics, Modeling, Systems Biology, Data Visualization Diseases Cancer, ...

  17. Acidic Residues in the Hfq Chaperone Increase the Selectivity of sRNA Binding and Annealing.

    PubMed

    Panja, Subrata; Santiago-Frangos, Andrew; Schu, Daniel J; Gottesman, Susan; Woodson, Sarah A

    2015-11-01

    Hfq facilitates gene regulation by small non-coding RNAs (sRNAs), thereby affecting bacterial attributes such as biofilm formation and virulence. Escherichia coli Hfq recognizes specific U-rich and AAN motifs in sRNAs and target mRNAs, after which an arginine patch on the rim promotes base pairing between their complementary sequences. In the cell, Hfq must discriminate between many similar RNAs. Here, we report that acidic amino acids lining the sRNA binding channel between the inner pore and rim of the Hfq hexamer contribute to the selectivity of Hfq's chaperone activity. RNase footprinting, in vitro binding and stopped-flow fluorescence annealing assays showed that alanine substitution of D9, E18 or E37 strengthened RNA interactions with the rim of Hfq and increased annealing of non-specific or U-tailed RNA oligomers. Although the mutants were less able than wild-type Hfq to anneal sRNAs with wild-type rpoS mRNA, the D9A mutation bypassed recruitment of Hfq to an (AAN)4 motif in rpoS, both in vitro and in vivo. These results suggest that acidic residues normally modulate access of RNAs to the arginine patch. We propose that this selectivity limits indiscriminate target selection by E. coli Hfq and enforces binding modes that favor genuine sRNA and mRNA pairs.

  18. sRNATarBase: a comprehensive database of bacterial sRNA targets verified by experiments.

    PubMed

    Cao, Yuan; Wu, Jiayao; Liu, Qian; Zhao, Yalin; Ying, Xiaomin; Cha, Lei; Wang, Ligui; Li, Wuju

    2010-11-01

    Bacterial sRNAs are an emerging class of small regulatory RNAs, 40-500 nt in length, which play a variety of important roles in many biological processes through binding to their mRNA or protein targets. A comprehensive database of experimentally confirmed sRNA targets would be helpful in understanding sRNA functions systematically and provide support for developing prediction models. Here we report on such a database--sRNATarBase. The database holds 138 sRNA-target interactions and 252 noninteraction entries, which were manually collected from peer-reviewed papers. The detailed information for each entry, such as supporting experimental protocols, BLAST-based phylogenetic analysis of sRNA-mRNA target interaction in closely related bacteria, predicted secondary structures for both sRNAs and their targets, and available binding regions, is provided as accurately as possible. This database also provides hyperlinks to other databases including GenBank, SWISS-PROT, and MPIDB. The database is available from the web page http://ccb.bmi.ac.cn/srnatarbase/.

  19. Self-incompatibility: Smi silences through a novel sRNA pathway.

    PubMed

    Finnegan, E Jean; Liang, Dacheng; Wang, Ming-Bo

    2011-05-01

    Self-incompatibility in Brassicaceae is determined by the interaction between S-Locus Protein 11 (SP11) on the pollen and S-receptor kinase (SRK) in the stigma. Pollen from heterozygotes generally displays products of both SP11 alleles, but in some heterozygotes SP11 expression is monoallelic, with one allele (SP11(R)) being silenced by promoter methylation. An exciting development in understanding the mechanism behind monoallelic silencing came recently when Y. Tarutani et al. [Nature 2010;466:983-986] identified a 24-nucleotide sRNA (termed Smi) derived from a non-coding gene within the dominant S-haplotype, and suggested that Smi directs promoter methylation. We propose that rather than having a direct effect on DNA methylation, Smi is the first step in a novel cis-acting siRNA pathway that directs widespread monoallelic SP11(R) promoter methylation. PMID:21306936

  20. Self-incompatibility: Smi silences through a novel sRNA pathway.

    PubMed

    Finnegan, E Jean; Liang, Dacheng; Wang, Ming-Bo

    2011-05-01

    Self-incompatibility in Brassicaceae is determined by the interaction between S-Locus Protein 11 (SP11) on the pollen and S-receptor kinase (SRK) in the stigma. Pollen from heterozygotes generally displays products of both SP11 alleles, but in some heterozygotes SP11 expression is monoallelic, with one allele (SP11(R)) being silenced by promoter methylation. An exciting development in understanding the mechanism behind monoallelic silencing came recently when Y. Tarutani et al. [Nature 2010;466:983-986] identified a 24-nucleotide sRNA (termed Smi) derived from a non-coding gene within the dominant S-haplotype, and suggested that Smi directs promoter methylation. We propose that rather than having a direct effect on DNA methylation, Smi is the first step in a novel cis-acting siRNA pathway that directs widespread monoallelic SP11(R) promoter methylation.

  1. A multicopy sRNA of Listeria monocytogenes regulates expression of the virulence adhesin LapB

    PubMed Central

    Sievers, Susanne; Sternkopf Lillebæk, Eva Maria; Jacobsen, Kirstine; Lund, Anja; Mollerup, Maria Storm; Nielsen, Pia Kiil; Kallipolitis, Birgitte Haahr

    2014-01-01

    The multicopy sRNA LhrC of the intracellular pathogen Listeria monocytogenes has been shown to be induced under infection-relevant conditions, but its physiological role and mechanism of action is not understood. In an attempt to pinpoint the exact terms of LhrC expression, cell envelope stress could be defined as a specific inducer of LhrC. In this process, the two-component system LisRK was shown to be indispensable for expression of all five copies of LhrC. lapB mRNA, encoding a cell wall associated protein that was recently identified as an important virulence factor, was disclosed to be directly bound by LhrC leading to an impediment of its translation. Although LhrC binds to Hfq, it does not require the RNA chaperone for stability or lapB mRNA interaction. The mechanism of LhrC-lapB mRNA binding was shown to involve three redundant CU-rich sites and a structural rearrangement in the sRNA. This study represents an extensive depiction of a so far uncharacterized multicopy sRNA and reveals interesting new aspects concerning its regulation, virulence association and mechanism of target binding. PMID:25034691

  2. An inhibitor of eIF2 activity in the sRNA pool of eukaryotic cells.

    PubMed

    Centrella, Michael; Porter, David L; McCarthy, Thomas L

    2011-08-15

    Eukaryotic protein synthesis is a multi-step and highly controlled process that includes an early initiation complex containing eukaryotic initiation factor 2 (eIF2), GTP, and methionine-charged initiator methionyl-tRNA (met-tRNAi). During studies to reconstruct formation of the ternary complex containing these molecules, we detected a potent inhibitor in low molecular mass RNA (sRNA) preparations of eukaryotic tRNA. The ternary complex inhibitor (TCI) was retained in the total sRNA pool after met-tRNAi was charged by aminoacyl tRNA synthetase, co-eluted with sRNA by size exclusion chromatography, but resolved from met-tRNAi by ion exchange chromatography. The adverse effect of TCI was not overcome by high GTP or magnesium omission and was independent of GTP regeneration. Rather, TCI suppressed the rate of ternary complex formation, and disrupted protein synthesis and the accumulation of heavy polymeric ribosomes in reticulocyte lysates in vitro. Lastly, a component or components in ribosome depleted cell lysate significantly reversed TCI activity. Since assembly of the met-tRNAi/eIF2/GTP ternary complex is integral to protein synthesis, awareness of TCI is important to avoid confusion in studies of translation initiation. A clear definition of TCI may also allow a better appreciation of physiologic or pathologic situations, factors, and events that control protein synthesis in vivo.

  3. Management of Incidental Findings in the Era of Next-generation Sequencing

    PubMed Central

    Blackburn, Heather L.; Schroeder, Bradley; Turner, Clesson; Shriver, Craig D.; Ellsworth, Darrell L.; Ellsworth, Rachel E.

    2015-01-01

    Next-generation sequencing (NGS) technologies allow for the generation of whole exome or whole genome sequencing data, which can be used to identify novel genetic alterations associated with defined phenotypes or to expedite discovery of functional variants for improved patient care. Because this robust technology has the ability to identify all mutations within a genome, incidental findings (IF)- genetic alterations associated with conditions or diseases unrelated to the patient’s present condition for which current tests are being performed- may have important clinical ramifications. The current debate among genetic scientists and clinicians focuses on the following questions: 1) should any IF be disclosed to patients, and 2) which IF should be disclosed – actionable mutations, variants of unknown significance, or all IF? Policies for disclosure of IF are being developed for when and how to convey these findings and whether adults, minors, or individuals unable to provide consent have the right to refuse receipt of IF. In this review, we detail current NGS technology platforms, discuss pressing issues regarding disclosure of IF, and how IF are currently being handled in prenatal, pediatric, and adult patients. PMID:26069456

  4. The CpxQ sRNA Negatively Regulates Skp To Prevent Mistargeting of β-Barrel Outer Membrane Proteins into the Cytoplasmic Membrane

    PubMed Central

    Koren, Daria

    2016-01-01

    ABSTRACT The promoter most strongly induced upon activation of the Cpx two-component envelope stress response is the cpxP promoter. The 3′ untranscribed region (UTR) of the cpxP transcript is shown to produce a small RNA (sRNA), CpxQ. We investigated the role of CpxQ in combating envelope stress. Remarkably, the two effectors specified by the transcript are deployed to combat distinct stresses in different cellular compartments. CpxP acts in both a regulatory negative-feedback loop and as an effector that combats periplasmic protein misfolding. We find that CpxQ combats toxicity at the inner membrane (IM) by downregulating the synthesis of the periplasmic chaperone Skp. Our data indicate that this regulation prevents Skp from inserting β-barrel outer membrane proteins (OMPs) into the IM, a lethal event that likely collapses the proton motive force. Our findings suggest that Skp can fold and directly insert OMPs into a lipid bilayer in vivo without the aid of the Bam complex. PMID:27048800

  5. C/D box sRNA, CRISPR RNA and tRNA processing in an archaeon with a minimal fragmented genome.

    PubMed

    Richter, Hagen; Mohr, Sabine; Randau, Lennart

    2013-02-01

    The analysis of deep sequencing data allows for a genome-wide overview of all the small RNA molecules (the 'sRNome') that are present in a single organism. In the present paper, we review the processing of CRISPR (clustered regularly interspaced short palindromic repeats) RNA, C/D box sRNA (small non-coding RNA) and tRNA in Nanoarchaeum equitans. The minimal and fragmented genome of this tiny archaeon permits a sequencing depth that enables the identification of processing intermediates in the study of RNA processing pathways. These intermediates include circular C/D box sRNA molecules and tRNA half precursors.

  6. Retiring the Generation Gap: How Employees Young and Old Can Find Common Ground

    ERIC Educational Resources Information Center

    Deal, Jennifer J.

    2007-01-01

    How different are the generations, really? Everybody knows that the "generation gap" between younger and older people causes stress and frustration at work. Are the differences people complain about just a big misunderstanding, or are they real? And most important, how can one use similarities and differences among the generations to be more…

  7. The Seventh Generation: Native Students Speak about Finding the Good Path.

    ERIC Educational Resources Information Center

    Bergstrom, Amy; Cleary, Linda Miller; Peacock, Thomas D.

    Many American Indian, First Nations, and Alaska Native cultures have prophecies about the "Seventh Generation"--young people who will have a spiritual and cultural awakening and lead the regeneration of the nations and the earth. This book honors the Seventh Generation. It draws on the words of 120 Native youth, interviewed in the United States…

  8. A new cis-encoded sRNA, BsrH, regulating the expression of hemH gene in Brucella abortus 2308.

    PubMed

    Peng, Xiaowei; Dong, Hao; Wu, Qingmin

    2015-01-01

    A total of 129 sRNA candidates were identified in Brucella abortus 2308 in our previous work, and one candidate with potential to regulate expression of hemH gene was further analyzed in this study. We found that the novel sRNA can inhibit the expression of hemH and called it BsrH (Brucella sRNA regulating HemH). The expression level of BsrH was tested in four different stress conditions. A significant upregulation was detected during the growth in acidic and Brucella minimal media, as well as in the presence of hydroxyl peroxide, while iron deficiency caused the opposite effect. As expected, BsrH strongly affected the survival ratio of the Brucella cells under iron-limitation conditions, though overexpression of BsrH did not affect Brucella virulence. Thus, we conclude that BsrH plays a regulatory role in bacterial heme biosynthesis and can be considered as the first Brucella sRNA involved in stress responses.

  9. On Wiener-Masani's algorithm for finding the generating function of multivariate stochastic processes

    NASA Technical Reports Server (NTRS)

    Miamee, A. G.

    1988-01-01

    It is shown that the algorithms for determining the generating function and prediction error matrix of multivariate stationary stochastic processes developed by Wiener and Masani (1957), and later by Masani (1960) will work in some more general setting.

  10. The multicopy sRNA LhrC controls expression of the oligopeptide-binding protein OppA in Listeria monocytogenes

    PubMed Central

    Sievers, Susanne; Lund, Anja; Menendez-Gil, Pilar; Nielsen, Aaraby; Storm Mollerup, Maria; Lambert Nielsen, Stine; Buch Larsson, Pernille; Borch-Jensen, Jonas; Johansson, Jörgen; Kallipolitis, Birgitte Haahr

    2015-01-01

    Listeria monocytogenes is the causative agent of the foodborne disease listeriosis. During infection, L. monocytogenes produces an array of non-coding RNAs, including the multicopy sRNA LhrC. These five, nearly identical sRNAs are highly induced in response to cell envelope stress and target the virulence adhesin lapB at the post-transcriptional level. Here, we demonstrate that LhrC controls expression of additional genes encoding cell envelope-associated proteins with virulence function. Using transcriptomics and proteomics, we identified a set of genes affected by LhrC in response to cell envelope stress. Three targets were significantly down-regulated by LhrC at both the RNA and protein level: lmo2349, tcsA and oppA. All three genes encode membrane-associated proteins: A putative substrate binding protein of an amino acid ABC transporter (Lmo2349); the CD4+ T cell-stimulating antigen TcsA, and the oligopeptide binding protein OppA, of which the latter 2 are required for full virulence of L. monocytogenes. For OppA, we show that LhrC acts by direct base paring to the ribosome binding site of the oppA mRNA, leading to an impediment of its translation and a decreased mRNA level. The sRNA-mRNA interaction depends on 2 of 3 CU-rich regions in LhrC allowing binding of 2 oppA mRNAs to a single LhrC molecule. Finally, we found that LhrC contributes to infection in macrophage-like cells. These findings demonstrate a central role for LhrC in controlling the level of OppA and other virulence-associated cell envelope proteins in response to cell envelope stress. PMID:26176322

  11. The VrrA sRNA controls a stationary phase survival factor Vrp of Vibrio cholerae.

    PubMed

    Sabharwal, Dharmesh; Song, Tianyan; Papenfort, Kai; Wai, Sun Nyunt

    2015-01-01

    Small non-coding RNAs (sRNAs) are emerging regulatory elements in bacteria. The Vibrio cholerae sRNA VrrA has previously been shown to down-regulate outer membrane proteins (OmpA and OmpT) and biofilm matrix protein (RbmC) by base-pairing with the 5' region of the corresponding mRNAs. In this study, we present an additional target of VrrA in V. cholerae, the mRNA coding for the ribosome binding protein Vrp. Vrp is homologous to ribosome-associated inhibitor A (RaiA) of Escherichia coli which facilitates stationary phase survival through ribosome hibernation. We show that VrrA down-regulates Vrp protein synthesis by base-pairing to the 5' region of vrp mRNA and that the regulation requires the RNA chaperone protein, Hfq. We further demonstrate that Vrp is highly expressed during stationary phase growth and associates with the ribosome of V. cholerae. The effect of the Vrp protein in starvation survival is synergistic with that of the VC2530 protein, a homolog of the E. coli hibernation promoting factor HPF, suggesting a combined role for these proteins in ribosome hibernation in V. cholerae. Vrp and VC2530 are important for V. cholerae starvation survival under nutrient deficient conditions. While VC2530 is down-regulated in cells lacking vrrA, mutation of vrp results in VC2530 activation. This is the first report indicating a regulatory role for an sRNA, modulating stationary factors involved in bacterial ribosome hibernation.

  12. Generative Perspectives on Language Acquisition: Empirical Findings, Theoretical Considerations, and Crosslinguistic Comparisons.

    ERIC Educational Resources Information Center

    Clahsen, Harald, Ed.

    The collection of essays and studies concerning generative grammar and first and second language acquisition includes: "The Optional-Infinitive Stage in Child English: Evidence from Negation" (Tony Harris, Ken Wexler); "Towards a Structure-Building Model of Acquisition" (Andrew Radford); "The Underspecification of Functional Categories in Early…

  13. Community views of inter-generational sex: findings from focus groups in Botswana, Namibia and Swaziland.

    PubMed

    Cockcroft, Anne; Kunda, John Lengwe; Kgakole, Leagajang; Masisi, Mokgweetsi; Laetsang, Ditiro; Ho-Foster, Ari; Marokoane, Nobantu; Andersson, Neil

    2010-10-01

    Inter-generational sex is an important driver of the AIDS epidemic in Southern Africa, contributing to the high incidence of HIV among young women. We conducted 12 focus group discussions with women aged 15-24 years and 11 with men aged 40-55 years in urban and rural locations in Botswana, Namibia and Swaziland. There was consensus that inter-generational sex is commonplace. The young women were clear they had sex with older men to get money and material goods. In urban sites, they spoke about requirements for a "modern" lifestyle and to keep up with their friends, but in rural sites they also said they needed money for school fees, food and household goods. Young women used disparaging names for the older men and they were well aware of the risk of HIV from inter-generational sex. They believed older men were more risky than younger men: They were more likely to be infected and it was harder to negotiate use of a condom with them. They were willing to take the risk to get what they wanted; some also had a fatalistic attitude. Older men described sexual motivation and blamed young women for seducing them. They believed there was a higher risk of HIV from younger women, because they have more partners and do not insist on using a condom. But this did not deter them from taking the risk. Older men and young women discount the risks of inter-generational sex against short-term benefits. Isolated efforts to increase risk awareness are unlikely to be effective. Making older men aware they are ridiculed by young women may be a promising approach, combined with interventions that give alternatives to young women and increase their self-worth. PMID:20835961

  14. On the Wiener-Masani algorithm for finding the generating function of multivariate stochastic processes

    NASA Technical Reports Server (NTRS)

    Miamee, A. G.

    1988-01-01

    The algorithms developed by Wiener and Masani (1957 and 1958) and Masani (1960) for the characterization of a class of multivariate stationary stochastic processes are investigated analytically. The algorithms permit the determination of (1) the generating function, (2) the prediction-error matrix, and (3) an autoregressive representation of the linear least-squares predictor. A number of theorems and lemmas are proved, and it is shown that the range of validity of the algorithms can be extended significantly beyond that given by Wiener and Masani.

  15. Generation X arrives at medical school to find changing expectations, growing pressures.

    PubMed

    OReilly, M

    1995-01-15

    Students entering medical school today face a health care system that is vastly different from the one new students experienced in the 1970s and 1980s. Michael OReilly interviewed five first-year students from the University of Western Ontario to learn about the hopes and dreams of medicine's next generation and the pressures facing these students. The Class of '98 doesn't appear intimidated by the cutbacks practising physicians are facing. As one student put it, these students won't be yearning for the "good old days" because "we don't have any good old days to remember."

  16. An Algorithm for Finding Candidate Synaptic Sites in Computer Generated Networks of Neurons with Realistic Morphologies

    PubMed Central

    van Pelt, Jaap; Carnell, Andrew; de Ridder, Sander; Mansvelder, Huibert D.; van Ooyen, Arjen

    2010-01-01

    Neurons make synaptic connections at locations where axons and dendrites are sufficiently close in space. Typically the required proximity is based on the dimensions of dendritic spines and axonal boutons. Based on this principle one can search those locations in networks formed by reconstructed neurons or computer generated neurons. Candidate synapses are then located where axons and dendrites are within a given criterion distance from each other. Both experimentally reconstructed and model generated neurons are usually represented morphologically by piecewise-linear structures (line pieces or cylinders). Proximity tests are then performed on all pairs of line pieces from both axonal and dendritic branches. Applying just a test on the distance between line pieces may result in local clusters of synaptic sites when more than one pair of nearby line pieces from axonal and dendritic branches is sufficient close, and may introduce a dependency on the length scale of the individual line pieces. The present paper describes a new algorithm for defining locations of candidate synapses which is based on the crossing requirement of a line piece pair, while the length of the orthogonal distance between the line pieces is subjected to the distance criterion for testing 3D proximity. PMID:21160548

  17. Next generation sequencing on patients with LGMD and nonspecific myopathies: Findings associated with ANO5 mutations

    PubMed Central

    Savarese, Marco; Di Fruscio, Giuseppina; Tasca, Giorgio; Ruggiero, Lucia; Janssens, Sandra; De Bleecker, Jan; Delpech, Marc; Musumeci, Olimpia; Toscano, Antonio; Angelini, Corrado; Sacconi, Sabrina; Santoro, Lucio; Ricci, Enzo; Claes, Kathleen; Politano, Luisa; Nigro, Vincenzo

    2015-01-01

    We studied 786 undiagnosed patients with LGMD or nonspecific myopathic features to investigate the role of ANO5 mutations in limb-girdle muscular dystrophies (LGMDs) and in nonspecific myopathies using the next generation sequencing (NGS) approach. In 160 LGMD patients, we first sequenced hotspot exons 5 and 20 and then sequenced the remaining part of the coding region. Another 626 patients, recruited using broader inclusion criteria, were directly analyzed by targeted NGS. By combining NGS and Sanger sequencing, we identified 33/786 (4%) patients carrying putative pathogenic changes in both alleles and 23 ANO5 heterozygotes (3%). The phenotypic spectrum is broader than expected, from hyperCKemia to myopathies, with lack of genotype/phenotype correlations. In particular, this is currently the largest screening of the ANO5 gene. The large number of heterozygotes for damaging mutations suggests that anoctaminopathies should be frequent and often nonpenetrant. We propose the multiple genetic testing by targeted NGS as a first step to analyze patients with nonspecific myopathic presentations. This represents a straightforward approach to overcome the difficulties of clinical heterogeneity of ANO5 patients, and to test, at the same time, many other genes involved in neuromuscular disorders. PMID:25891276

  18. Steam generator fretting-wear damage: A summary of recent findings

    SciTech Connect

    Guerout, F.M.; Fisher, N.J.

    1999-08-01

    Flow-induced vibration of steam generator (SG) tubes may sometimes result in fretting-wear damage at the tube-to-support locations. Fretting-wear damage predictions are largely based on experimental data obtained at representative test conditions. Fretting-wear of SG materials has been studied at the Chalk River Laboratories for two decades. Tests are conducted in fretting-wear test machines that simulate SG environmental conditions and tube-to-support dynamic interactions. A new high-temperature force and displacement measuring system was developed to monitor tube-to-support interaction (i.e., work-rate) at operating conditions. This improvement in experimental fretting-wear technology was used to perform a comprehensive study of the effect of various environment and design parameters on SG tube wear damage. This paper summarizes the results of tests performed over the past 4 yr to study the effect of temperature, water chemistry, support geometry, and tube material on fretting-wear. The results show a significant effect of temperature on tube wear damage. Therefore, fretting-wear tests must be performed at operating temperatures in order to be relevant. No significant effect of the type of water treatment on tube wear damage was observed. For predominantly impacting motion, the wear of SG tubes in contact with 410 stainless steel is similar regardless of whether Alloy 690 or Alloy 800 is used as tubing material or whether lattice bars or broached hole supports are used. Based on results presented in this paper, an average wear coefficient value is recommended that is used for the prediction of SG tube wear depth versus time.

  19. A cis-encoded sRNA, Hfq and mRNA secondary structure act independently to suppress IS200 transposition

    PubMed Central

    Ellis, Michael J.; Trussler, Ryan S.; Haniford, David B.

    2015-01-01

    IS200 is found throughout Enterobacteriaceae and transposes at a notoriously low frequency. In addition to the transposase protein (TnpA), IS200 encodes an uncharacterized Hfq-binding sRNA that is encoded opposite to the tnpA 5'UTR. In the current work we asked if this sRNA represses tnpA expression. We show here that the IS200 sRNA (named art200 for antisense regulator of transposase IS200) basepairs with tnpA to inhibit translation initiation. Unexpectedly, art200-tnpA pairing is limited to 40 bp, despite 90 nt of perfect complementarity. Additionally, we show that Hfq and RNA secondary structure in the tnpA 5'UTR each repress tnpA expression in an art200-independent manner. Finally, we show that disrupting translational control of tnpA expression leads to increased IS200 transposition in E. coli. The current work provides new mechanistic insight into why IS200 transposition is so strongly suppressed. The possibility of art200 acting in trans to regulate a yet-unidentified target is discussed as well as potential applications of the IS200 system for designing novel riboregulators. PMID:26044710

  20. Synthesis and characterization of a new four-layer Aurivillius phase Bi 2SrNa 2Nb 4O 15 and its protonated form

    NASA Astrophysics Data System (ADS)

    Liang, Zhenhua; Tang, Kaibin; Zeng, Suyuan; Wang, Dong; Li, Tanwei; Zheng, Huagui

    2008-10-01

    A new four-layer Aurivillius phase Bi 2SrNa 2Nb 4O 15 has been synthesized by solid-state reaction of Bi 2SrNb 2O 9 and NaNbO 3 at 1100 °C. The detailed structure determination of Bi 2SrNa 2Nb 4O 15 performed by powder X-ray diffraction (XRD) shows that it crystallizes in the space group I4/ mmm [ a˜3.9021(1) Å, c˜40.7554(10) Å]. Protonated form of Bi 2SrNa 2Nb 4O 15 was obtained by the substitution of bismuth oxide sheets with protons via acid treatment. The conversion into the protonated forms was achieved easily using 6 M HCl at room temperature. Preservation of the structure of the perovskite-like slabs and contraction in the c-axis were confirmed by X-ray analysis. The compositions of the resulting products were determined to be H 1.8[Sr 0.8Bi 0.2Na 2Nb 4O 13] by X-ray fluorescence spectroscopy (XFS) and thermogravimetry.

  1. Dual-function sRNA encoded peptide SR1P modulates moonlighting activity of B. subtilis GapA

    PubMed Central

    Gimpel, Matthias; Brantl, Sabine

    2016-01-01

    ABSTRACT SR1 is a dual-function sRNA from B. subtilis that acts as a base-pairing regulatory RNA and as a peptide-encoding mRNA. Both functions of SR1 are highly conserved. Previously, we uncovered that the SR1 encoded peptide SR1P binds the glycolytic enzyme GapA resulting in stabilization of gapA mRNA. Here, we demonstrate that GapA interacts with RNases Y and J1, and this interaction was RNA-independent. About 1% of GapA molecules purified from B. subtilis carry RNase J1 and about 2% RNase Y. In contrast to the GapA/RNase Y interaction, the GapA/RNaseJ1 interaction was stronger in the presence of SR1P. GapA/SR1P-J1/Y displayed in vitro RNase activity on known RNase J1 substrates. Moreover, the RNase J1 substrate SR5 has altered half-lives in a ΔgapA strain and a Δsr1 strain, suggesting in vivo functions of the GapA/SR1P/J1 interaction. Our results demonstrate that the metabolic enzyme GapA moonlights in recruiting RNases while GapA bound SR1P promotes binding of RNase J1 and enhances its activity. PMID:27449348

  2. Antagonistic functions between the RNA chaperone Hfq and an sRNA regulate sensitivity to the antibiotic colicin.

    PubMed

    Salvail, Hubert; Caron, Marie-Pier; Bélanger, Justine; Massé, Eric

    2013-10-16

    The RNA chaperone Hfq is a key regulator of the function of small RNAs (sRNAs). Hfq has been shown to facilitate sRNAs binding to target mRNAs and to directly regulate translation through the action of sRNAs. Here, we present evidence that Hfq acts as the repressor of cirA mRNA translation in the absence of sRNA. Hfq binding to cirA prevents translation initiation, which correlates with cirA mRNA instability. In contrast, RyhB pairing to cirA mRNA promotes changes in RNA structure that displace Hfq, thereby allowing efficient translation as well as mRNA stabilization. Because CirA is a receptor for the antibiotic colicin Ia, in addition to acting as an Fur (Ferric Uptake Regulator)-regulated siderophore transporter, translational activation of cirA mRNA by RyhB promotes colicin sensitivity under conditions of iron starvation. Altogether, these results indicate that Fur and RyhB modulate an unexpected feed-forward loop mechanism related to iron physiology and colicin sensitivity. PMID:24065131

  3. Antagonistic functions between the RNA chaperone Hfq and an sRNA regulate sensitivity to the antibiotic colicin

    PubMed Central

    Salvail, Hubert; Caron, Marie-Pier; Bélanger, Justine; Massé, Eric

    2013-01-01

    The RNA chaperone Hfq is a key regulator of the function of small RNAs (sRNAs). Hfq has been shown to facilitate sRNAs binding to target mRNAs and to directly regulate translation through the action of sRNAs. Here, we present evidence that Hfq acts as the repressor of cirA mRNA translation in the absence of sRNA. Hfq binding to cirA prevents translation initiation, which correlates with cirA mRNA instability. In contrast, RyhB pairing to cirA mRNA promotes changes in RNA structure that displace Hfq, thereby allowing efficient translation as well as mRNA stabilization. Because CirA is a receptor for the antibiotic colicin Ia, in addition to acting as an Fur (Ferric Uptake Regulator)-regulated siderophore transporter, translational activation of cirA mRNA by RyhB promotes colicin sensitivity under conditions of iron starvation. Altogether, these results indicate that Fur and RyhB modulate an unexpected feed-forward loop mechanism related to iron physiology and colicin sensitivity. PMID:24065131

  4. Random number generation in bilingual Balinese and German students: preliminary findings from an exploratory cross-cultural study.

    PubMed

    Strenge, Hans; Lesmana, Cokorda Bagus Jaya; Suryani, Luh Ketut

    2009-08-01

    Verbal random number generation is a procedurally simple task to assess executive function and appears ideally suited for the use under diverse settings in cross-cultural research. The objective of this study was to examine ethnic group differences between young adults in Bali (Indonesia) and Kiel (Germany): 50 bilingual healthy students, 30 Balinese and 20 Germans, attempted to generate a random sequence of the digits 1 to 9. In Balinese participants, randomization was done in Balinese (native language L1) and Indonesian (first foreign language L2), in German subjects in the German (L1) and English (L2) languages. 10 of 30 Balinese (33%), but no Germans, were unable to inhibit habitual counting in more than half of the responses. The Balinese produced significantly more nonrandom responses than the Germans with higher rates of counting and significantly less occurrence of the digits 2 and 3 in L1 compared with L2. Repetition and cycling behavior did not differ between the four languages. The findings highlight the importance of taking into account culture-bound psychosocial factors for Balinese individuals when administering and interpreting a random number generation test. PMID:19831087

  5. Random number generation in bilingual Balinese and German students: preliminary findings from an exploratory cross-cultural study.

    PubMed

    Strenge, Hans; Lesmana, Cokorda Bagus Jaya; Suryani, Luh Ketut

    2009-08-01

    Verbal random number generation is a procedurally simple task to assess executive function and appears ideally suited for the use under diverse settings in cross-cultural research. The objective of this study was to examine ethnic group differences between young adults in Bali (Indonesia) and Kiel (Germany): 50 bilingual healthy students, 30 Balinese and 20 Germans, attempted to generate a random sequence of the digits 1 to 9. In Balinese participants, randomization was done in Balinese (native language L1) and Indonesian (first foreign language L2), in German subjects in the German (L1) and English (L2) languages. 10 of 30 Balinese (33%), but no Germans, were unable to inhibit habitual counting in more than half of the responses. The Balinese produced significantly more nonrandom responses than the Germans with higher rates of counting and significantly less occurrence of the digits 2 and 3 in L1 compared with L2. Repetition and cycling behavior did not differ between the four languages. The findings highlight the importance of taking into account culture-bound psychosocial factors for Balinese individuals when administering and interpreting a random number generation test.

  6. Reflecting on Earlier Experiences with Unsolicited Findings: Points to Consider for Next-Generation Sequencing and Informed Consent in Diagnostics

    PubMed Central

    Rigter, Tessel; Henneman, Lidewij; Kristoffersson, Ulf; Hall, Alison; Yntema, Helger G; Borry, Pascal; Tönnies, Holger; Waisfisz, Quinten; Elting, Mariet W; Dondorp, Wybo J; Cornel, Martina C

    2013-01-01

    High-throughput nucleotide sequencing (often referred to as next-generation sequencing; NGS) is increasingly being chosen as a diagnostic tool for cases of expected but unresolved genetic origin. When exploring a higher number of genetic variants, there is a higher chance of detecting unsolicited findings. The consequential increased need for decisions on disclosure of these unsolicited findings poses a challenge for the informed consent procedure. This article discusses the ethical and practical dilemmas encountered when contemplating informed consent for NGS in diagnostics from a multidisciplinary point of view. By exploring recent similar experiences with unsolicited findings in other settings, an attempt is made to describe what can be learned so far for implementing NGS in standard genetic diagnostics. The article concludes with a set of points to consider in order to guide decision-making on the extent of return of results in relation to the mode of informed consent. We hereby aim to provide a sound basis for developing guidelines for optimizing the informed consent procedure. PMID:23784691

  7. Reflecting on earlier experiences with unsolicited findings: points to consider for next-generation sequencing and informed consent in diagnostics.

    PubMed

    Rigter, Tessel; Henneman, Lidewij; Kristoffersson, Ulf; Hall, Alison; Yntema, Helger G; Borry, Pascal; Tönnies, Holger; Waisfisz, Quinten; Elting, Mariet W; Dondorp, Wybo J; Cornel, Martina C

    2013-10-01

    High-throughput nucleotide sequencing (often referred to as next-generation sequencing; NGS) is increasingly being chosen as a diagnostic tool for cases of expected but unresolved genetic origin. When exploring a higher number of genetic variants, there is a higher chance of detecting unsolicited findings. The consequential increased need for decisions on disclosure of these unsolicited findings poses a challenge for the informed consent procedure. This article discusses the ethical and practical dilemmas encountered when contemplating informed consent for NGS in diagnostics from a multidisciplinary point of view. By exploring recent similar experiences with unsolicited findings in other settings, an attempt is made to describe what can be learned so far for implementing NGS in standard genetic diagnostics. The article concludes with a set of points to consider in order to guide decision-making on the extent of return of results in relation to the mode of informed consent. We hereby aim to provide a sound basis for developing guidelines for optimizing the informed consent procedure.

  8. The Impact of 18 Ancestral and Horizontally-Acquired Regulatory Proteins upon the Transcriptome and sRNA Landscape of Salmonella enterica serovar Typhimurium

    PubMed Central

    Colgan, Aoife M.; Diard, Médéric; Hardt, Wolf-Dietrich; Puente, José L.; Sivasankaran, Sathesh K.; Hokamp, Karsten; Hinton, Jay C. D.

    2016-01-01

    We know a great deal about the genes used by the model pathogen Salmonella enterica serovar Typhimurium to cause disease, but less about global gene regulation. New tools for studying transcripts at the single nucleotide level now offer an unparalleled opportunity to understand the bacterial transcriptome, and expression of the small RNAs (sRNA) and coding genes responsible for the establishment of infection. Here, we define the transcriptomes of 18 mutants lacking virulence-related global regulatory systems that modulate the expression of the SPI1 and SPI2 Type 3 secretion systems of S. Typhimurium strain 4/74. Using infection-relevant growth conditions, we identified a total of 1257 coding genes that are controlled by one or more regulatory system, including a sub-class of genes that reflect a new level of cross-talk between SPI1 and SPI2. We directly compared the roles played by the major transcriptional regulators in the expression of sRNAs, and discovered that the RpoS (σ38) sigma factor modulates the expression of 23% of sRNAs, many more than other regulatory systems. The impact of the RNA chaperone Hfq upon the steady state levels of 280 sRNA transcripts is described, and we found 13 sRNAs that are co-regulated with SPI1 and SPI2 virulence genes. We report the first example of an sRNA, STnc1480, that is subject to silencing by H-NS and subsequent counter-silencing by PhoP and SlyA. The data for these 18 regulatory systems is now available to the bacterial research community in a user-friendly online resource, SalComRegulon. PMID:27564394

  9. The Impact of 18 Ancestral and Horizontally-Acquired Regulatory Proteins upon the Transcriptome and sRNA Landscape of Salmonella enterica serovar Typhimurium.

    PubMed

    Colgan, Aoife M; Kröger, Carsten; Diard, Médéric; Hardt, Wolf-Dietrich; Puente, José L; Sivasankaran, Sathesh K; Hokamp, Karsten; Hinton, Jay C D

    2016-08-01

    We know a great deal about the genes used by the model pathogen Salmonella enterica serovar Typhimurium to cause disease, but less about global gene regulation. New tools for studying transcripts at the single nucleotide level now offer an unparalleled opportunity to understand the bacterial transcriptome, and expression of the small RNAs (sRNA) and coding genes responsible for the establishment of infection. Here, we define the transcriptomes of 18 mutants lacking virulence-related global regulatory systems that modulate the expression of the SPI1 and SPI2 Type 3 secretion systems of S. Typhimurium strain 4/74. Using infection-relevant growth conditions, we identified a total of 1257 coding genes that are controlled by one or more regulatory system, including a sub-class of genes that reflect a new level of cross-talk between SPI1 and SPI2. We directly compared the roles played by the major transcriptional regulators in the expression of sRNAs, and discovered that the RpoS (σ38) sigma factor modulates the expression of 23% of sRNAs, many more than other regulatory systems. The impact of the RNA chaperone Hfq upon the steady state levels of 280 sRNA transcripts is described, and we found 13 sRNAs that are co-regulated with SPI1 and SPI2 virulence genes. We report the first example of an sRNA, STnc1480, that is subject to silencing by H-NS and subsequent counter-silencing by PhoP and SlyA. The data for these 18 regulatory systems is now available to the bacterial research community in a user-friendly online resource, SalComRegulon. PMID:27564394

  10. Antagonistic control of the turnover pathway for the global regulatory sRNA CsrB by the CsrA and CsrD proteins

    PubMed Central

    Vakulskas, Christopher A.; Leng, Yuanyuan; Abe, Hazuki; Amaki, Takumi; Okayama, Akihiro; Babitzke, Paul; Suzuki, Kazushi; Romeo, Tony

    2016-01-01

    The widely conserved protein CsrA (carbon storage regulator A) globally regulates bacterial gene expression at the post-transcriptional level. In many species, CsrA activity is governed by untranslated sRNAs, CsrB and CsrC in Escherichia coli, which bind to multiple CsrA dimers, sequestering them from lower affinity mRNA targets. Both the synthesis and turnover of CsrB/C are regulated. Their turnover requires the housekeeping endonuclease RNase E and is activated by the presence of a preferred carbon source via the binding of EIIAGlc of the glucose transport system to the GGDEF-EAL domain protein CsrD. We demonstrate that the CsrB 3′ segment contains the features necessary for CsrD-mediated decay. RNase E cleavage in an unstructured segment located immediately upstream from the intrinsic terminator is necessary for subsequent degradation to occur. CsrA stabilizes CsrB against RNase E cleavage by binding to two canonical sites adjacent to the necessary cleavage site, while CsrD acts by overcoming CsrA-mediated protection. Our genetic, biochemical and structural studies establish a molecular framework for sRNA turnover by the CsrD-RNase E pathway. We propose that CsrD evolution was driven by the selective advantage of decoupling Csr sRNA decay from CsrA binding, connecting it instead to the availability of a preferred carbon source. PMID:27235416

  11. Box C/D sRNA stem ends act as stabilizing anchors for box C/D di-sRNPs

    PubMed Central

    Yip, W. S. Vincent; Shigematsu, Hideki; Taylor, David W.; Baserga, Susan J.

    2016-01-01

    Ribosomal RNA (rRNA) modifications are essential for ribosome function in all cellular organisms. Box C/D small (nucleolar) ribonucleoproteins [s(no)RNPs] catalyze 2′-O-methylation, one rRNA modification type in Eukarya and Archaea. Negatively stained electron microscopy (EM) models of archaeal box C/D sRNPs have demonstrated the dimeric sRNP (di-sRNP) architecture, which has been corroborated by nuclear magnetic resonance (NMR) studies. Due to limitations of the structural techniques, the orientation of the box C/D sRNAs has remained unclear. Here, we have used cryo-EM to elucidate the sRNA orientation in a M. jannaschii box C/D di-sRNP. The cryo-EM reconstruction suggests a parallel orientation of the two sRNAs. Biochemical and structural analyses of sRNPs assembled with mutant sRNAs indicate a potential interaction between the sRNA stem ends. Our results suggest that the parallel arrangement of the sRNAs juxtaposes their stem ends into close proximity to allow for a stabilizing interaction that helps maintain the di-sRNP architecture. PMID:27342279

  12. Finding Purpose in Pain: Using Logotherapy as a Method for Addressing Survivor Guilt in First-Generation College Students

    ERIC Educational Resources Information Center

    Tate, Kevin A.; Williams, Cyrus, III; Harden, Dia

    2013-01-01

    First-generation college students face a variety of academic and personal challenges, including survivor guilt (Piorkowski, 1983). Survivor guilt for these students involves negative emotions related to leaving family and friends "behind" in difficult contexts and lived experiences. This article provides (a) an overview of first-generation college…

  13. Small RNAs in angiosperms: sequence characteristics, distribution and generation.

    PubMed

    Chen, Dijun; Meng, Yijun; Ma, Xiaoxia; Mao, Chuanzao; Bai, Youhuang; Cao, Junjie; Gu, Haibin; Wu, Ping; Chen, Ming

    2010-06-01

    High-throughput sequencing (HTS) has opened up a new era for small RNA (sRNA) exploration. Using HTS data for a global survey of sRNAs in 26 angiosperms, elevated GC contents were detected in the monocots, whereas the 5(')-terminal compositions were quite uniform among the angiosperms. Chromosome-wide distribution patterns of sRNAs were investigated by using scrolling-window analysis. We performed de novo natural antisense transcript (NAT) prediction, and found that the overlapping regions of trans-NATs, but not cis-NATs, were hotspots for sRNA generation. One cis-NAT generates phased natural antisense short interfering RNAs (nat-siRNAs) specifically from flowers in Arabidopsis, while one in rice produces phased nat-siRNAs from grains, suggesting their organ-specific regulatory roles. PMID:20378553

  14. Small RNAs in angiosperms: sequence characteristics, distribution and generation.

    PubMed

    Chen, Dijun; Meng, Yijun; Ma, Xiaoxia; Mao, Chuanzao; Bai, Youhuang; Cao, Junjie; Gu, Haibin; Wu, Ping; Chen, Ming

    2010-06-01

    High-throughput sequencing (HTS) has opened up a new era for small RNA (sRNA) exploration. Using HTS data for a global survey of sRNAs in 26 angiosperms, elevated GC contents were detected in the monocots, whereas the 5(')-terminal compositions were quite uniform among the angiosperms. Chromosome-wide distribution patterns of sRNAs were investigated by using scrolling-window analysis. We performed de novo natural antisense transcript (NAT) prediction, and found that the overlapping regions of trans-NATs, but not cis-NATs, were hotspots for sRNA generation. One cis-NAT generates phased natural antisense short interfering RNAs (nat-siRNAs) specifically from flowers in Arabidopsis, while one in rice produces phased nat-siRNAs from grains, suggesting their organ-specific regulatory roles.

  15. Assessing Adolescents' Communicative Self-Efficacy to Discuss Controversial Issues: Findings from a Randomized Study of the Word Generation Program

    ERIC Educational Resources Information Center

    Lin, Alex R.; Lawrence, Joshua F.; Snow, Catherine E.; Taylor, Karen S.

    2016-01-01

    Communicative self-efficacy serves as an important link between discussing controversial issues and civic engagement because confidence in one's discourse skills is important to managing conflicting perspectives and developing solutions to community-based problems. Freely available to schools, "Word Generation" is a cross-content…

  16. Improving Mathematics Learning by Integrating Curricular Activities with Innovative and Developmentally Appropriate Digital Apps: Findings from the Next Generation Preschool Math Evaluation

    ERIC Educational Resources Information Center

    Presser, Ashley Lewis; Vahey, Philip; Dominguez, Ximena

    2015-01-01

    This paper describes findings from a blocked randomized design (BRD) field study conducted to examine the "Next Generation Preschool Math" (NGPM) program's implementation in preschool classrooms and promise in improving young children's mathematic learning. NGPM integrates traditional preschool activities with developmentally appropriate…

  17. Adult congenital heart disease imaging with second-generation dual-source computed tomography: initial experiences and findings.

    PubMed

    Ghoshhajra, Brian B; Sidhu, Manavjot S; El-Sherief, Ahmed; Rojas, Carlos; Yeh, Doreen Defaria; Engel, Leif-Christopher; Liberthson, Richard; Abbara, Suhny; Bhatt, Ami

    2012-01-01

    Adult congenital heart disease patients present a unique challenge to the cardiac imager. Patients may present with both acute and chronic manifestations of their complex congenital heart disease and also require surveillance for sequelae of their medical and surgical interventions. Multimodality imaging is often required to clarify their anatomy and physiology. Radiation dose is of particular concern in these patients with lifelong imaging needs for their chronic disease. The second-generation dual-source scanner is a recently available advanced clinical cardiac computed tomography (CT) scanner. It offers a combination of the high-spatial resolution of modern CT, the high-temporal resolution of dual-source technology, and the wide z-axis coverage of modern cone-beam geometry CT scanners. These advances in technology allow novel protocols that markedly reduce scan time, significantly reduce radiation exposure, and expand the physiologic imaging capabilities of cardiac CT. We present a case series of complicated adult congenital heart disease patients imaged by the second-generation dual-source CT scanner with extremely low-radiation doses and excellent image quality.

  18. Waking Up the Mind: Qualitative Study Findings About the Process Through Which Programs Combining Income Generation and Health Education Can Empower Indigenous Guatemalan Women.

    PubMed

    Gurman, Tilly A; Ballard, Anne; Kerr, Samantha; Walsh, Janée; Petrocy, Amy

    2016-01-01

    We explored the process through which two income-generation programs that include health education empower indigenous Guatemalan women artisans. Both artisans (n = 44) and program staff (n = 11) participated in semistructured interviews. Respondents expressed that women gained support about personal issues and experienced an awakening of the mind (despertar la mente). Through active participation, women's fear of strangers and speaking in public decreased. Women also gained mobility, awareness of their rights as women, and self-confidence from earning and managing their own income. Given our findings, we suggest that programs combining income generation and health education have the potential to empower women.

  19. Waking Up the Mind: Qualitative Study Findings About the Process Through Which Programs Combining Income Generation and Health Education Can Empower Indigenous Guatemalan Women.

    PubMed

    Gurman, Tilly A; Ballard, Anne; Kerr, Samantha; Walsh, Janée; Petrocy, Amy

    2016-01-01

    We explored the process through which two income-generation programs that include health education empower indigenous Guatemalan women artisans. Both artisans (n = 44) and program staff (n = 11) participated in semistructured interviews. Respondents expressed that women gained support about personal issues and experienced an awakening of the mind (despertar la mente). Through active participation, women's fear of strangers and speaking in public decreased. Women also gained mobility, awareness of their rights as women, and self-confidence from earning and managing their own income. Given our findings, we suggest that programs combining income generation and health education have the potential to empower women. PMID:25635700

  20. Mitochondrial COI and 16sRNA evidence for a single species hypothesis of E. vitis, J. formosana and E. onukii in East Asia.

    PubMed

    Fu, Jian-Yu; Han, Bao-Yu; Xiao, Qiang

    2014-01-01

    Tea green leafhopper is one of the most damaging tea pests in main tea production regions of East Asia. For lack of recognized morphological characters, the dominant species of tea green leafhoppers in Mainland China, Taiwan and Japan have always been named as Empoasca vitis Göthe, Jacobiasca formosana Paoli and Empoasca onukii MATSUDA, respectively. Furthermore, nothing is known about the genetic relationships among them. In this study, we collected six populations from Mainland China, four populations from Japan and one population from Taiwan, and examined the genetic distances in the COI and 16sRNA regions of mtDNA among them. The results showed that the genetic distances based on single gene or the combined sequences among eleven leafhopper populations were 0.3-1.2%, which were all less than the species boundary of 2%. Moreover, there were at least two haplotypes shared by two distinct populations from different regions. The phylogenetic analysis based on single gene or combined sets also supported that tea green leafhoppers from Mainland China, Taiwan and Japan were closely related to each other, and there were at least two specimens from different regions clustered ahead of those from the same region. Therefore, we propose that the view of recognizing the dominant species of tea green leafhoppers in three adjacent tea production regions of East Asia as different species is unreliable or questionable and suggest that they are a single species. PMID:25506929

  1. MicL, a new σE-dependent sRNA, combats envelope stress by repressing synthesis of Lpp, the major outer membrane lipoprotein

    PubMed Central

    Guo, Monica S.; Updegrove, Taylor B.; Gogol, Emily B.; Shabalina, Svetlana A.; Gross, Carol A.; Storz, Gisela

    2014-01-01

    In enteric bacteria, the transcription factor σE maintains membrane homeostasis by inducing synthesis of proteins involved in membrane repair and two small regulatory RNAs (sRNAs) that down-regulate synthesis of abundant membrane porins. Here, we describe the discovery of a third σE-dependent sRNA, MicL (mRNA-interfering complementary RNA regulator of Lpp), transcribed from a promoter located within the coding sequence of the cutC gene. MicL is synthesized as a 308-nucleotide (nt) primary transcript that is processed to an 80-nt form. Both forms possess features typical of Hfq-binding sRNAs but surprisingly target only a single mRNA, which encodes the outer membrane lipoprotein Lpp, the most abundant protein of the cell. We show that the copper sensitivity phenotype previously ascribed to inactivation of the cutC gene is actually derived from the loss of MicL and elevated Lpp levels. This observation raises the possibility that other phenotypes currently attributed to protein defects are due to deficiencies in unappreciated regulatory RNAs. We also report that σE activity is sensitive to Lpp abundance and that MicL and Lpp comprise a new σE regulatory loop that opposes membrane stress. Together MicA, RybB, and MicL allow σE to repress the synthesis of all abundant outer membrane proteins in response to stress. PMID:25030700

  2. Generations.

    PubMed

    Chambers, David W

    2005-01-01

    Groups naturally promote their strengths and prefer values and rules that give them an identity and an advantage. This shows up as generational tensions across cohorts who share common experiences, including common elders. Dramatic cultural events in America since 1925 can help create an understanding of the differing value structures of the Silents, the Boomers, Gen Xers, and the Millennials. Differences in how these generations see motivation and values, fundamental reality, relations with others, and work are presented, as are some applications of these differences to the dental profession. PMID:16623137

  3. The sRNA NsiR4 is involved in nitrogen assimilation control in cyanobacteria by targeting glutamine synthetase inactivating factor IF7.

    PubMed

    Klähn, Stephan; Schaal, Christoph; Georg, Jens; Baumgartner, Desirée; Knippen, Gernot; Hagemann, Martin; Muro-Pastor, Alicia M; Hess, Wolfgang R

    2015-11-10

    Glutamine synthetase (GS), a key enzyme in biological nitrogen assimilation, is regulated in multiple ways in response to varying nitrogen sources and levels. Here we show a small regulatory RNA, NsiR4 (nitrogen stress-induced RNA 4), which plays an important role in the regulation of GS in cyanobacteria. NsiR4 expression in the unicellular Synechocystis sp. PCC 6803 and in the filamentous, nitrogen-fixing Anabaena sp. PCC 7120 is stimulated through nitrogen limitation via NtcA, the global transcriptional regulator of genes involved in nitrogen metabolism. NsiR4 is widely conserved throughout the cyanobacterial phylum, suggesting a conserved function. In silico target prediction, transcriptome profiling on pulse overexpression, and site-directed mutagenesis experiments using a heterologous reporter system showed that NsiR4 interacts with the 5'UTR of gifA mRNA, which encodes glutamine synthetase inactivating factor (IF)7. In Synechocystis, we observed an inverse relationship between the levels of NsiR4 and the accumulation of IF7 in vivo. This NsiR4-dependent modulation of gifA (IF7) mRNA accumulation influenced the glutamine pool and thus [Formula: see text] assimilation via GS. As a second target, we identified ssr1528, a hitherto uncharacterized nitrogen-regulated gene. Competition experiments between WT and an ΔnsiR4 KO mutant showed that the lack of NsiR4 led to decreased acclimation capabilities of Synechocystis toward oscillating nitrogen levels. These results suggest a role for NsiR4 in the regulation of nitrogen metabolism in cyanobacteria, especially for the adaptation to rapid changes in available nitrogen sources and concentrations. NsiR4 is, to our knowledge, the first identified bacterial sRNA regulating the primary assimilation of a macronutrient. PMID:26494284

  4. The sRNA NsiR4 is involved in nitrogen assimilation control in cyanobacteria by targeting glutamine synthetase inactivating factor IF7.

    PubMed

    Klähn, Stephan; Schaal, Christoph; Georg, Jens; Baumgartner, Desirée; Knippen, Gernot; Hagemann, Martin; Muro-Pastor, Alicia M; Hess, Wolfgang R

    2015-11-10

    Glutamine synthetase (GS), a key enzyme in biological nitrogen assimilation, is regulated in multiple ways in response to varying nitrogen sources and levels. Here we show a small regulatory RNA, NsiR4 (nitrogen stress-induced RNA 4), which plays an important role in the regulation of GS in cyanobacteria. NsiR4 expression in the unicellular Synechocystis sp. PCC 6803 and in the filamentous, nitrogen-fixing Anabaena sp. PCC 7120 is stimulated through nitrogen limitation via NtcA, the global transcriptional regulator of genes involved in nitrogen metabolism. NsiR4 is widely conserved throughout the cyanobacterial phylum, suggesting a conserved function. In silico target prediction, transcriptome profiling on pulse overexpression, and site-directed mutagenesis experiments using a heterologous reporter system showed that NsiR4 interacts with the 5'UTR of gifA mRNA, which encodes glutamine synthetase inactivating factor (IF)7. In Synechocystis, we observed an inverse relationship between the levels of NsiR4 and the accumulation of IF7 in vivo. This NsiR4-dependent modulation of gifA (IF7) mRNA accumulation influenced the glutamine pool and thus [Formula: see text] assimilation via GS. As a second target, we identified ssr1528, a hitherto uncharacterized nitrogen-regulated gene. Competition experiments between WT and an ΔnsiR4 KO mutant showed that the lack of NsiR4 led to decreased acclimation capabilities of Synechocystis toward oscillating nitrogen levels. These results suggest a role for NsiR4 in the regulation of nitrogen metabolism in cyanobacteria, especially for the adaptation to rapid changes in available nitrogen sources and concentrations. NsiR4 is, to our knowledge, the first identified bacterial sRNA regulating the primary assimilation of a macronutrient.

  5. The sRNA NsiR4 is involved in nitrogen assimilation control in cyanobacteria by targeting glutamine synthetase inactivating factor IF7

    PubMed Central

    Klähn, Stephan; Schaal, Christoph; Georg, Jens; Baumgartner, Desirée; Knippen, Gernot; Hagemann, Martin; Muro-Pastor, Alicia M.; Hess, Wolfgang R.

    2015-01-01

    Glutamine synthetase (GS), a key enzyme in biological nitrogen assimilation, is regulated in multiple ways in response to varying nitrogen sources and levels. Here we show a small regulatory RNA, NsiR4 (nitrogen stress-induced RNA 4), which plays an important role in the regulation of GS in cyanobacteria. NsiR4 expression in the unicellular Synechocystis sp. PCC 6803 and in the filamentous, nitrogen-fixing Anabaena sp. PCC 7120 is stimulated through nitrogen limitation via NtcA, the global transcriptional regulator of genes involved in nitrogen metabolism. NsiR4 is widely conserved throughout the cyanobacterial phylum, suggesting a conserved function. In silico target prediction, transcriptome profiling on pulse overexpression, and site-directed mutagenesis experiments using a heterologous reporter system showed that NsiR4 interacts with the 5′UTR of gifA mRNA, which encodes glutamine synthetase inactivating factor (IF)7. In Synechocystis, we observed an inverse relationship between the levels of NsiR4 and the accumulation of IF7 in vivo. This NsiR4-dependent modulation of gifA (IF7) mRNA accumulation influenced the glutamine pool and thus NH4+ assimilation via GS. As a second target, we identified ssr1528, a hitherto uncharacterized nitrogen-regulated gene. Competition experiments between WT and an ΔnsiR4 KO mutant showed that the lack of NsiR4 led to decreased acclimation capabilities of Synechocystis toward oscillating nitrogen levels. These results suggest a role for NsiR4 in the regulation of nitrogen metabolism in cyanobacteria, especially for the adaptation to rapid changes in available nitrogen sources and concentrations. NsiR4 is, to our knowledge, the first identified bacterial sRNA regulating the primary assimilation of a macronutrient. PMID:26494284

  6. Integration Host Factor Is Required for RpoN-Dependent hrpL Gene Expression and Controls Motility by Positively Regulating rsmB sRNA in Erwinia amylovora.

    PubMed

    Lee, Jae Hoon; Zhao, Youfu

    2016-01-01

    Erwinia amylovora requires an hrp-type III secretion system (T3SS) to cause disease. It has been reported that HrpL, the master regulator of T3SS, is transcriptionally regulated by sigma factor 54 (RpoN), YhbH, and HrpS. In this study, the role of integration host factor (IHF) in regulating hrpL and T3SS gene expression was investigated. IHF is a nucleoid-associated protein that regulates gene expression by influencing nucleoid structure and DNA bending. Our results showed that both ihfA and ihfB mutants of E. amylovora did not induce necrotic lesions on pear fruits. Growth of both mutants was greatly reduced, and expression of the hrpL and T3SS genes was significantly down-regulated as compared with those of the wild type. In addition, expression of the ihfA, but not the ihfB gene, was under auto-suppression by IHF. Furthermore, both ihfA and ihfB mutants were hypermotile, due to significantly reduced expression of small RNA (sRNA) rsmB. Electrophoresis mobility shift assay further confirmed that IHF binds to the promoters of the hrpL and ihfA genes, as well as the rsmB sRNA gene. These results indicate that IHF is required for RpoN-dependent hrpL gene expression and virulence, and controls motility by positively regulating the rsmB sRNA in E. amylovora.

  7. Fast-forward generation of effective artificial small RNAs for enhanced antiviral defense in plants

    PubMed Central

    Carbonell, Alberto; Carrington, James C.; Daròs, José-Antonio

    2016-01-01

    Artificial small RNAs (sRNAs) are short ≈21-nt non-coding RNAs engineered to inactivate sequence complementary RNAs. In plants, they have been extensively used to silence cellular transcripts in gene function analyses and to target invading RNA viruses to induce resistance. Current artificial sRNA-based antiviral resistance in plants is mainly limited to a single virus, and is jeopardized by the emergence of mutations in the artificial sRNA target site or by the presence of co-infecting viruses. Hence, there is a need to further develop the artificial sRNA approach to generate more broad and durable antiviral resistance in plants. A recently developed toolbox allows for the time and cost-effective large-scale production of artificial sRNA constructs in plants. The toolbox includes the P-SAMS web tool for the automated design of artificial sRNAs, and a new generation of artificial microRNA and synthetic trans-acting small interfering RNA (syn-tasiRNA) vectors for direct cloning and high expression of artificial sRNAs. Here we describe how the simplicity and high-throughput capability of these new technologies should accelerate the study of artificial sRNA-based antiviral resistance in plants. In particular, we discuss the potential of the syn-tasiRNA approach as a promising strategy for developing more effective, durable and broad antiviral resistance in plants. PMID:26925463

  8. Evaluation of a binary optimization approach to find the optimum locations of energy storage devices in a power grid with stochastically varying loads and wind generation

    NASA Astrophysics Data System (ADS)

    Dar, Zamiyad

    The prices in the electricity market change every five minutes. The prices in peak demand hours can be four or five times more than the prices in normal off peak hours. Renewable energy such as wind power has zero marginal cost and a large percentage of wind energy in a power grid can reduce the price significantly. The variability of wind power prevents it from being constantly available in peak hours. The price differentials between off-peak and on-peak hours due to wind power variations provide an opportunity for a storage device owner to buy energy at a low price and sell it in high price hours. In a large and complex power grid, there are many locations for installation of a storage device. Storage device owners prefer to install their device at locations that allow them to maximize profit. Market participants do not possess much information about the system operator's dispatch, power grid, competing generators and transmission system. The publicly available data from the system operator usually consists of Locational Marginal Prices (LMP), load, reserve prices and regulation prices. In this thesis, we develop a method to find the optimum location of a storage device without using the grid, transmission or generator data. We formulate and solve an optimization problem to find the most profitable location for a storage device using only the publicly available market pricing data such as LMPs, and reserve prices. We consider constraints arising due to storage device operation limitations in our objective function. We use binary optimization and branch and bound method to optimize the operation of a storage device at a given location to earn maximum profit. We use two different versions of our method and optimize the profitability of a storage unit at each location in a 36 bus model of north eastern United States and south eastern Canada for four representative days representing four seasons in a year. Finally, we compare our results from the two versions of our

  9. The Next Generation of Risk Assessment Multi-Year Study—Highlights of Findings, Applications to Risk Assessment, and Future Directions

    PubMed Central

    Cote, Ila; Andersen, Melvin E.; Ankley, Gerald T.; Barone, Stanley; Birnbaum, Linda S.; Boekelheide, Kim; Bois, Frederic Y.; Burgoon, Lyle D.; Chiu, Weihsueh A.; Crawford-Brown, Douglas; Crofton, Kevin M.; DeVito, Michael; Devlin, Robert B.; Edwards, Stephen W.; Guyton, Kathryn Z.; Hattis, Dale; Judson, Richard S.; Knight, Derek; Krewski, Daniel; Lambert, Jason; Maull, Elizabeth Anne; Mendrick, Donna; Paoli, Gregory M.; Patel, Chirag Jagdish; Perkins, Edward J.; Poje, Gerald; Portier, Christopher J.; Rusyn, Ivan; Schulte, Paul A.; Simeonov, Anton; Smith, Martyn T.; Thayer, Kristina A.; Thomas, Russell S.; Thomas, Reuben; Tice, Raymond R.; Vandenberg, John J.; Villeneuve, Daniel L.; Wesselkamper, Scott; Whelan, Maurice; Whittaker, Christine; White, Ronald; Xia, Menghang; Yauk, Carole; Zeise, Lauren; Zhao, Jay; DeWoskin, Robert S.

    2016-01-01

    Background: The Next Generation (NexGen) of Risk Assessment effort is a multi-year collaboration among several organizations evaluating new, potentially more efficient molecular, computational, and systems biology approaches to risk assessment. This article summarizes our findings, suggests applications to risk assessment, and identifies strategic research directions. Objective: Our specific objectives were to test whether advanced biological data and methods could better inform our understanding of public health risks posed by environmental exposures. Methods: New data and methods were applied and evaluated for use in hazard identification and dose–response assessment. Biomarkers of exposure and effect, and risk characterization were also examined. Consideration was given to various decision contexts with increasing regulatory and public health impacts. Data types included transcriptomics, genomics, and proteomics. Methods included molecular epidemiology and clinical studies, bioinformatic knowledge mining, pathway and network analyses, short-duration in vivo and in vitro bioassays, and quantitative structure activity relationship modeling. Discussion: NexGen has advanced our ability to apply new science by more rapidly identifying chemicals and exposures of potential concern, helping characterize mechanisms of action that influence conclusions about causality, exposure–response relationships, susceptibility and cumulative risk, and by elucidating new biomarkers of exposure and effects. Additionally, NexGen has fostered extensive discussion among risk scientists and managers and improved confidence in interpreting and applying new data streams. Conclusions: While considerable uncertainties remain, thoughtful application of new knowledge to risk assessment appears reasonable for augmenting major scope assessments, forming the basis for or augmenting limited scope assessments, and for prioritization and screening of very data limited chemicals. Citation: Cote I

  10. Does war contribute to family violence against children? Findings from a two-generational multi-informant study in Northern Uganda.

    PubMed

    Saile, Regina; Ertl, Verena; Neuner, Frank; Catani, Claudia

    2014-01-01

    After 20 years of civil war in Northern Uganda, the continuity of violence within the family constitutes a major challenge to children's healthy development in the post-conflict era. Previous exposure to trauma and ongoing psychopathology in guardians potentially contribute to parental perpetration against children and dysfunctional interactions in the child's family ecology that increase children's risk of maltreatment. In order to investigate distal and proximal risk factors of child victimization, we first aimed to identify factors leading to more self-reported perpetration in guardians. Second, we examined factors in the child's family environment that promote child-reported experiences of maltreatment. Using a two-generational design we interviewed 368 children, 365 female guardians, and 304 male guardians from seven war-affected rural communities in Northern Uganda on the basis of standardized questionnaires. We found that the strongest predictors of self-reported aggressive parenting behaviors toward the child were guardians' own experiences of childhood maltreatment, followed by female guardians' victimization experiences in their intimate relationship and male guardians' posttrautmatic stress disorder (PTSD) symptoms and alcohol-related problems. Regarding children's self-report of victimization in the family, proximal factors including violence between adults in the household and male guardians' PTSD symptom severity level predicted higher levels of maltreatment. Distal variables such as female guardians' history of childhood victimization and female guardians' exposure to traumatic war events also increased children's report of maltreatment. The current findings suggest that in the context of organized violence, an intergenerational cycle of violence persists that is exacerbated by female guardians' re-victimization experiences and male guardians' psychopathological symptoms. PMID:24239222

  11. Does war contribute to family violence against children? Findings from a two-generational multi-informant study in Northern Uganda.

    PubMed

    Saile, Regina; Ertl, Verena; Neuner, Frank; Catani, Claudia

    2014-01-01

    After 20 years of civil war in Northern Uganda, the continuity of violence within the family constitutes a major challenge to children's healthy development in the post-conflict era. Previous exposure to trauma and ongoing psychopathology in guardians potentially contribute to parental perpetration against children and dysfunctional interactions in the child's family ecology that increase children's risk of maltreatment. In order to investigate distal and proximal risk factors of child victimization, we first aimed to identify factors leading to more self-reported perpetration in guardians. Second, we examined factors in the child's family environment that promote child-reported experiences of maltreatment. Using a two-generational design we interviewed 368 children, 365 female guardians, and 304 male guardians from seven war-affected rural communities in Northern Uganda on the basis of standardized questionnaires. We found that the strongest predictors of self-reported aggressive parenting behaviors toward the child were guardians' own experiences of childhood maltreatment, followed by female guardians' victimization experiences in their intimate relationship and male guardians' posttrautmatic stress disorder (PTSD) symptoms and alcohol-related problems. Regarding children's self-report of victimization in the family, proximal factors including violence between adults in the household and male guardians' PTSD symptom severity level predicted higher levels of maltreatment. Distal variables such as female guardians' history of childhood victimization and female guardians' exposure to traumatic war events also increased children's report of maltreatment. The current findings suggest that in the context of organized violence, an intergenerational cycle of violence persists that is exacerbated by female guardians' re-victimization experiences and male guardians' psychopathological symptoms.

  12. Generation of a high resolution map of sRNAs from Fusarium graminearum and analysis of responses to viral infection.

    PubMed

    Wang, Shuangchao; Li, Pengfei; Zhang, Jingze; Qiu, Dewen; Guo, Lihua

    2016-01-01

    Previously, we characterized F. graminearum hypovirus 1 (FgHV1) and F. graminearum hypovirus 2 (FgHV2), which are the only two hypoviruses in F. graminearum that are closely related to Cryphonectria hypovirus 1 (CHV1) and Cryphonectria hypovirus 2 (CHV2) in the Hypoviridae family. In this study, we preliminarily elucidated the RNA silencing mechanism of the F. graminearum/hypovirus system from a small RNA (sRNA) perspective by using HiSeq deep sequencing. The length distributions of F. graminearum sRNA were altered by hypoviral infection. Potential microRNA-like (milRNA) candidates were differentially expressed between the hypovirus-free and hypovirus-infected library types. Extensive virus-derived small interfering RNAs (vsiRNAs) were also principally defined. The 1,831,081 and 3,254,758 total reads generated from the FgHV1 and FgHV2 genomes in F. graminearum yielded the first high-resolution sRNA maps of fungal viruses. In addition, extensive bioinformatics searches identified a large number of transcripts that are potentially targeted by vsiRNAs, several of which were effectively down-regulated. In particular, the RNA silencing-related genes FgDicer1 and FgRdRp5 were predicted targets of FgHV1- and FgHV2-derived siRNAs, possibly revealing a novel anti-RNA silencing strategy employed by mycoviruses. PMID:27189438

  13. Generation of a high resolution map of sRNAs from Fusarium graminearum and analysis of responses to viral infection

    PubMed Central

    Wang, Shuangchao; Li, Pengfei; Zhang, Jingze; Qiu, Dewen; Guo, Lihua

    2016-01-01

    Previously, we characterized F. graminearum hypovirus 1 (FgHV1) and F. graminearum hypovirus 2 (FgHV2), which are the only two hypoviruses in F. graminearum that are closely related to Cryphonectria hypovirus 1 (CHV1) and Cryphonectria hypovirus 2 (CHV2) in the Hypoviridae family. In this study, we preliminarily elucidated the RNA silencing mechanism of the F. graminearum/hypovirus system from a small RNA (sRNA) perspective by using HiSeq deep sequencing. The length distributions of F. graminearum sRNA were altered by hypoviral infection. Potential microRNA-like (milRNA) candidates were differentially expressed between the hypovirus-free and hypovirus-infected library types. Extensive virus-derived small interfering RNAs (vsiRNAs) were also principally defined. The 1,831,081 and 3,254,758 total reads generated from the FgHV1 and FgHV2 genomes in F. graminearum yielded the first high-resolution sRNA maps of fungal viruses. In addition, extensive bioinformatics searches identified a large number of transcripts that are potentially targeted by vsiRNAs, several of which were effectively down-regulated. In particular, the RNA silencing-related genes FgDicer1 and FgRdRp5 were predicted targets of FgHV1- and FgHV2-derived siRNAs, possibly revealing a novel anti-RNA silencing strategy employed by mycoviruses. PMID:27189438

  14. Generation of a high resolution map of sRNAs from Fusarium graminearum and analysis of responses to viral infection.

    PubMed

    Wang, Shuangchao; Li, Pengfei; Zhang, Jingze; Qiu, Dewen; Guo, Lihua

    2016-01-01

    Previously, we characterized F. graminearum hypovirus 1 (FgHV1) and F. graminearum hypovirus 2 (FgHV2), which are the only two hypoviruses in F. graminearum that are closely related to Cryphonectria hypovirus 1 (CHV1) and Cryphonectria hypovirus 2 (CHV2) in the Hypoviridae family. In this study, we preliminarily elucidated the RNA silencing mechanism of the F. graminearum/hypovirus system from a small RNA (sRNA) perspective by using HiSeq deep sequencing. The length distributions of F. graminearum sRNA were altered by hypoviral infection. Potential microRNA-like (milRNA) candidates were differentially expressed between the hypovirus-free and hypovirus-infected library types. Extensive virus-derived small interfering RNAs (vsiRNAs) were also principally defined. The 1,831,081 and 3,254,758 total reads generated from the FgHV1 and FgHV2 genomes in F. graminearum yielded the first high-resolution sRNA maps of fungal viruses. In addition, extensive bioinformatics searches identified a large number of transcripts that are potentially targeted by vsiRNAs, several of which were effectively down-regulated. In particular, the RNA silencing-related genes FgDicer1 and FgRdRp5 were predicted targets of FgHV1- and FgHV2-derived siRNAs, possibly revealing a novel anti-RNA silencing strategy employed by mycoviruses.

  15. The Generation R Study: A Review of Design, Findings to Date, and a Study of the 5-HTTLPR by Environmental Interaction from Fetal Life Onward

    ERIC Educational Resources Information Center

    Tiemeier, Henning; Velders, Fleur P.; Szekely, Eszter; Roza, Sabine J.; Dieleman, Gwen; Jaddoe, Vincent W. V.; Uitterlinden, Andre G.; White, Tonya J. H.; Bakermans-Kranenburg, Marian J.; Hofman, Albert; Van IJzendoorn, Marinus H.; Hudziak, James J.; Verhulst, Frank C.

    2012-01-01

    Objective: First, we give an overview of child psychiatric research in the Generation R Study, a population-based cohort from fetal life forward. Second, we examine within Generation R whether the functional polymorphism (5-HTTLPR) in the promoter of the serotonin transporter gene interacts with prenatal maternal chronic difficulties, prenatal…

  16. TECHNICAL SUPPORT DOCUMENT: NATIONAL-SCALE MERCURY RISK ASSESSMENT SUPPORTING THE APPROPRIATE AND NECESSARY FINDING FOR COAL- AND OIL-FIRED ELECTRIC GENERATING UNITS

    EPA Science Inventory

    The EPA has completed a national-scale risk assessment for mercury to inform the appropriate and necessary determination for electric utility steam generating unites in the United States (U.S. EGU's), persuant to Section 112(n)(1)(A) of the Clean Air Act. This document describes...

  17. Rock Finding

    ERIC Educational Resources Information Center

    Rommel-Esham, Katie; Constable, Susan D.

    2006-01-01

    In this article, the authors discuss a literature-based activity that helps students discover the importance of making detailed observations. In an inspiring children's classic book, "Everybody Needs a Rock" by Byrd Baylor (1974), the author invites readers to go "rock finding," laying out 10 rules for finding a "perfect" rock. In this way, the…

  18. Direction finding of half-gyrofrequency VLF emissions in the off-equatorial region of the magnetosphere and their generation and propagation

    SciTech Connect

    Muto, H.; Hayakawa, M. ); Parrot, M.; Lefeuvre, F. )

    1987-07-01

    The spectra of VLF/ELF emissions in the off-equatorial region in the outer magnetosphere are, on occasion, found to consist of upper and lower bands with a frequency gap between them. The wave normal directions of the upper band VLF emissions have been determined by means of wave distribution function analyses based first on the measurement of three magnetic field components only, and then with the additional use of an electric field component. It is found that the wave distribution functions are composed of two peaks whose central wave normal angles {theta} with respect to the magnetic field at a geomagnetic latitude of {approximately} 17{degree} are close to the local oblique resonance cone {theta}{sub res} but whose values of {theta} are always about 15{degree}-20{degree} less than {theta}{sub res} at a higher latitude of {approximately}26{degree}. This observed wave normal behavior is compared with the theoretical prediction from direct ray tracing studies using the hypothesis deduced from a previous investigation that the waves are generated at the equator with wave normals close to {theta}{sub res}. A combination of this comparison and inverse ray tracing in which the initial wave normal directions are those determined from the wave distribution analysis has yielded the results that the {theta} values of the upper band VLF emissions are very close to {theta}{sub res} at the equator and that the normalized frequency there, {Lambda}{sub eq}, is above 0.5. Hence the upper band VLF emissions are identified as being half-gyrofrequency VLF emissions generated in the vicinity of the magnetic equator, with their wave normals close to {theta}{sub res}. The characteristics of propagation between the equatorial source region and the observing positions have been investigated by direct ray tracing. The generation mechanism is also discussed.

  19. Finding a Potential Dipeptidyl Peptidase-4 (DPP-4) Inhibitor for Type-2 Diabetes Treatment Based on Molecular Docking, Pharmacophore Generation, and Molecular Dynamics Simulation.

    PubMed

    Meduru, Harika; Wang, Yeng-Tseng; Tsai, Jeffrey J P; Chen, Yu-Ching

    2016-06-13

    Dipeptidyl peptidase-4 (DPP-4) is the vital enzyme that is responsible for inactivating intestinal peptides glucagon like peptide-1 (GLP-1) and Gastric inhibitory polypeptide (GIP), which stimulates a decline in blood glucose levels. The aim of this study was to explore the inhibition activity of small molecule inhibitors to DPP-4 following a computational strategy based on docking studies and molecular dynamics simulations. The thorough docking protocol we applied allowed us to derive good correlation parameters between the predicted binding affinities (pKi) of the DPP-4 inhibitors and the experimental activity values (pIC50). Based on molecular docking receptor-ligand interactions, pharmacophore generation was carried out in order to identify the binding modes of structurally diverse compounds in the receptor active site. Consideration of the permanence and flexibility of DPP-4 inhibitor complexes by means of molecular dynamics (MD) simulation specified that the inhibitors maintained the binding mode observed in the docking study. The present study helps generate new information for further structural optimization and can influence the development of new DPP-4 inhibitors discoveries in the treatment of type-2 diabetes.

  20. Finding a Potential Dipeptidyl Peptidase-4 (DPP-4) Inhibitor for Type-2 Diabetes Treatment Based on Molecular Docking, Pharmacophore Generation, and Molecular Dynamics Simulation

    PubMed Central

    Meduru, Harika; Wang, Yeng-Tseng; Tsai, Jeffrey J. P.; Chen, Yu-Ching

    2016-01-01

    Dipeptidyl peptidase-4 (DPP-4) is the vital enzyme that is responsible for inactivating intestinal peptides glucagon like peptide-1 (GLP-1) and Gastric inhibitory polypeptide (GIP), which stimulates a decline in blood glucose levels. The aim of this study was to explore the inhibition activity of small molecule inhibitors to DPP-4 following a computational strategy based on docking studies and molecular dynamics simulations. The thorough docking protocol we applied allowed us to derive good correlation parameters between the predicted binding affinities (pKi) of the DPP-4 inhibitors and the experimental activity values (pIC50). Based on molecular docking receptor-ligand interactions, pharmacophore generation was carried out in order to identify the binding modes of structurally diverse compounds in the receptor active site. Consideration of the permanence and flexibility of DPP-4 inhibitor complexes by means of molecular dynamics (MD) simulation specified that the inhibitors maintained the binding mode observed in the docking study. The present study helps generate new information for further structural optimization and can influence the development of new DPP-4 inhibitors discoveries in the treatment of type-2 diabetes. PMID:27304951

  1. Finding the needle in the haystack: differentiating "identical" twins in paternity testing and forensics by ultra-deep next generation sequencing.

    PubMed

    Weber-Lehmann, Jacqueline; Schilling, Elmar; Gradl, Georg; Richter, Daniel C; Wiehler, Jens; Rolf, Burkhard

    2014-03-01

    Monozygotic (MZ) twins are considered being genetically identical, therefore they cannot be differentiated using standard forensic DNA testing. Here we describe how identification of extremely rare mutations by ultra-deep next generation sequencing can solve such cases. We sequenced DNA from sperm samples of two twins and from a blood sample of the child of one twin. Bioinformatics analysis revealed five single nucleotide polymorphisms (SNPs) present in the twin father and the child, but not in the twin uncle. The SNPs were confirmed by classical Sanger sequencing. Our results give experimental evidence for the hypothesis that rare mutations will occur early after the human blastocyst has split into two, the origin of twins, and that such mutations will be carried on into somatic tissue and the germline. The method provides a solution to solve paternity and forensic cases involving monozygotic twins as alleged fathers or originators of DNA traces. PMID:24528578

  2. Numerical investigation for finding the appropriate design parameters of a fin-and-tube heat exchanger with delta-winglet vortex generators

    NASA Astrophysics Data System (ADS)

    Behfard, M.; Sohankar, A.

    2016-01-01

    A numerical simulation is performed to investigate the heat transfer and pressure drop characteristics of three-row inline tube bundles as a part of a heat exchanger (Re = 1000, Pr = 4.29). To enhance heat transfer, two pairs of delta winglet-type vortex generators (VGs) installed beside the first row and between the first and second rows of the tube bundles. The diameter of the second row of the tubes is chosen smaller than those of the first and third. A comprehensive study on the effects of various geometrical parameters such as transverse and longitudinal positions of VGs, length and height of VGs and angle of attack of the delta winglets is performed to augment heat transfer. Based on this study the best values of these design parameters are determined. The results showed that the best model increases the convective heat transfer ratio and thermal performance factor about 59 and 43 %, respectively, in compare with the geometry without VG.

  3. Finding food

    PubMed Central

    Forsyth, Ann; Lytle, Leslie; Riper, David Van

    2011-01-01

    A significant amount of travel is undertaken to find food. This paper examines challenges in measuring access to food using Geographic Information Systems (GIS), important in studies of both travel and eating behavior. It compares different sources of data available including fieldwork, land use and parcel data, licensing information, commercial listings, taxation data, and online street-level photographs. It proposes methods to classify different kinds of food sales places in a way that says something about their potential for delivering healthy food options. In assessing the relationship between food access and travel behavior, analysts must clearly conceptualize key variables, document measurement processes, and be clear about the strengths and weaknesses of data. PMID:21837264

  4. Verb finding in aphasia.

    PubMed

    Kohn, S E; Lorch, M P; Pearson, D M

    1989-03-01

    Word finding for nouns and verbs was examined in a heterogeneous group of aphasics (N = 9) by comparing the ability to generate synonyms and sentences for the same set of 20 nouns and 20 verbs. Synonym Generation performance resembled that of an age-matched group of normal control subjects (n = 9): In both groups, some subjects produced comparable numbers of synonyms for nouns and verbs while other subjects produced significantly fewer synonyms for verbs. Essentially the same two patterns were displayed on Sentence Generation using the frequency of "empty" nouns (e.g., 'it', 'man') and "empty" verbs (e.g., 'is', 'do') as an index of word-finding difficulty: In both groups, some subjects produced comparable numbers of empty nouns and verbs, while other subjects produced significantly more empty verbs. However, the Sentence Generation performance of one aphasic subject stood out overall by her tendency to avoid empty verbs and produce incomplete sentences. This pattern of performance was interpreted as a breakdown in an early stage of sentence planning that may be directly related to her diagnosis of transcortical motor aphasia.

  5. miRMOD: a tool for identification and analysis of 5' and 3' miRNA modifications in Next Generation Sequencing small RNA data.

    PubMed

    Kaushik, Abhinav; Saraf, Shradha; Mukherjee, Sunil K; Gupta, Dinesh

    2015-01-01

    In the past decade, the microRNAs (miRNAs) have emerged to be important regulators of gene expression across various species. Several studies have confirmed different types of post-transcriptional modifications at terminal ends of miRNAs. The reports indicate that miRNA modifications are conserved and functionally significant as it may affect miRNA stability and ability to bind mRNA targets, hence affecting target gene repression. Next Generation Sequencing (NGS) of the small RNA (sRNA) provides an efficient and reliable method to explore miRNA modifications. The need for dedicated software, especially for users with little knowledge of computers, to determine and analyze miRNA modifications in sRNA NGS data, motivated us to develop miRMOD. miRMOD is a user-friendly, Microsoft Windows and Graphical User Interface (GUI) based tool for identification and analysis of 5' and 3' miRNA modifications (non-templated nucleotide additions and trimming) in sRNA NGS data. In addition to identification of miRNA modifications, the tool also predicts and compares the targets of query and modified miRNAs. In order to compare binding affinities for the same target, miRMOD utilizes minimum free energies of the miRNA:target and modified-miRNA:target interactions. Comparisons of the binding energies may guide experimental exploration of miRNA post-transcriptional modifications. The tool is available as a stand-alone package to overcome large data transfer problems commonly faced in web-based high-throughput (HT) sequencing data analysis tools. miRMOD package is freely available at http://bioinfo.icgeb.res.in/miRMOD. PMID:26623179

  6. Size Unbiased Representative Enzymatically Generated RNAi (SURER) Library and Application for RNAi Therapeutic Screens

    PubMed Central

    Li, Tiejun; Chen, Li; Sun, Yuncheng; Yuan, Jian; Graham, Michael; French, Peter

    2015-01-01

    RNA interference (RNAi) libraries screens have become widely used for small RNA (sRNA) therapeutic targets development. However, conventional enzymatically libraries, typically prepared using the type 2 restriction enzyme MmeI, produce sRNAs between 18 and 20 bp, much shorter than the usual lengths of 19–23 bp. Here we develop a size unbiased representative enzymatically generated RNAi (SURER) library, which employs type 3 restriction modification enzyme EcoP15I to produce sRNAs ranging from 19 to 23 bp using a group of rationally designed linkers, which can completely mimic the length of sRNAs naturally generated by Dicer enzyme in living cells, and the screening results of SURER libraries showed high recombination rate and knockdown efficiency. SURER library provides a useful tool for RNAi therapeutics screening in a fast and simple way. PMID:25493330

  7. Sustained safety and performance of the second-generation drug-eluting absorbable metal scaffold in patients with de novo coronary lesions: 12-month clinical results and angiographic findings of the BIOSOLVE-II first-in-man trial

    PubMed Central

    Haude, Michael; Ince, Hüseyin; Abizaid, Alexandre; Toelg, Ralph; Lemos, Pedro Alves; von Birgelen, Clemens; Christiansen, Evald Høj; Wijns, William; Neumann, Franz-Josef; Kaiser, Christoph; Eeckhout, Eric; Lim, Soo Teik; Escaned, Javier; Onuma, Yoshinobu; Garcia-Garcia, Hector M.; Waksman, Ron

    2016-01-01

    Aims Metal absorbable scaffolds constitute a conceptually attractive alternative to polymeric scaffolds. Promising 6-month outcomes of a second-generation drug-eluting absorbable metal scaffold (DREAMS 2G), consisting of an absorbable magnesium scaffold backbone, have been reported. We assessed the 12-month safety and performance of this novel device. Methods and results The prospective, international, multi-centre, first-in-man BIOSOLVE-II trial enrolled 123 patients with up to two de novo lesions with a reference diameter between 2.2 and 3.7 mm. All patients were scheduled for angiographic follow-up at 6 months, and—if subjects consented—at 12 months. Dual antiplatelet therapy was recommended for 6 months. Quantitative coronary angiography (QCA) parameters remained stable from 6 to 12 months [paired data of 42 patients: in-segment late lumen loss 0.20 ± 0.21 mm vs. 0.25 ± 0.22 mm, P = 0.117, Δ 0.05 ± 0.21 mm (95% CI: −0.01;0.12); in-scaffold late lumen loss 0.37 ± 0.25 mm vs. 0.39 ± 0.27 mm, P = 0.446, Δ 0.03 ± 0.22 (95% CI: −0.04;0.10), respectively]. Intravascular ultrasound and optical coherence tomography findings corroborated the QCA results. Target lesion failure occurred in four patients (3.4%), consisting of one death of unknown cause, one target-vessel myocardial infarction, and two clinically driven target lesion revascularization. No additional event occurred beyond the 6-month follow-up. During the entire follow-up of 12 months, none of the patients experienced a definite or probable scaffold thrombosis. Conclusion The novel drug-eluting metal absorbable scaffold DREAMS 2G showed a continuous favourable safety profile up to 12 months and stable angiographic parameters between 6 and 12 months. ClinicalTrials.gov identifier NCT01960504.

  8. Sustained safety and performance of the second-generation drug-eluting absorbable metal scaffold in patients with de novo coronary lesions: 12-month clinical results and angiographic findings of the BIOSOLVE-II first-in-man trial

    PubMed Central

    Haude, Michael; Ince, Hüseyin; Abizaid, Alexandre; Toelg, Ralph; Lemos, Pedro Alves; von Birgelen, Clemens; Christiansen, Evald Høj; Wijns, William; Neumann, Franz-Josef; Kaiser, Christoph; Eeckhout, Eric; Lim, Soo Teik; Escaned, Javier; Onuma, Yoshinobu; Garcia-Garcia, Hector M.; Waksman, Ron

    2016-01-01

    Aims Metal absorbable scaffolds constitute a conceptually attractive alternative to polymeric scaffolds. Promising 6-month outcomes of a second-generation drug-eluting absorbable metal scaffold (DREAMS 2G), consisting of an absorbable magnesium scaffold backbone, have been reported. We assessed the 12-month safety and performance of this novel device. Methods and results The prospective, international, multi-centre, first-in-man BIOSOLVE-II trial enrolled 123 patients with up to two de novo lesions with a reference diameter between 2.2 and 3.7 mm. All patients were scheduled for angiographic follow-up at 6 months, and—if subjects consented—at 12 months. Dual antiplatelet therapy was recommended for 6 months. Quantitative coronary angiography (QCA) parameters remained stable from 6 to 12 months [paired data of 42 patients: in-segment late lumen loss 0.20 ± 0.21 mm vs. 0.25 ± 0.22 mm, P = 0.117, Δ 0.05 ± 0.21 mm (95% CI: −0.01;0.12); in-scaffold late lumen loss 0.37 ± 0.25 mm vs. 0.39 ± 0.27 mm, P = 0.446, Δ 0.03 ± 0.22 (95% CI: −0.04;0.10), respectively]. Intravascular ultrasound and optical coherence tomography findings corroborated the QCA results. Target lesion failure occurred in four patients (3.4%), consisting of one death of unknown cause, one target-vessel myocardial infarction, and two clinically driven target lesion revascularization. No additional event occurred beyond the 6-month follow-up. During the entire follow-up of 12 months, none of the patients experienced a definite or probable scaffold thrombosis. Conclusion The novel drug-eluting metal absorbable scaffold DREAMS 2G showed a continuous favourable safety profile up to 12 months and stable angiographic parameters between 6 and 12 months. ClinicalTrials.gov identifier NCT01960504. PMID:27190094

  9. Leiomyosarcoma: computed tomographic findings

    SciTech Connect

    McLeod, A.J.; Zornoza, J.; Shirkhoda, A.

    1984-07-01

    The computed tomographic (CT) findings in 118 patients with the diagnosis of leiomyosarcoma were reviewed. The tumor masses visualized in these patients were often quite large; extensive necrotic or cystic change was a frequent finding. Calcification was not observed in these tumors. The liver was the most common site of metastasis in these patients, with marked necrosis of the liver lesions a common finding. Other manifestations of tumor spread included pulmonary metastases, mesenteric or omental metastases, retroperitoneal lymphadenopathy, soft-tissue metastases, bone metastases, splenic metastases, and ascites. Although the CT appearance of leiomyosarcoma is not specific, these findings, when present, suggest consideration of this diagnosis.

  10. Find a Nurse Practitioner

    MedlinePlus

    Find a Nurse Practitioner AANP Home MyAANP Contact Us Find an NP near me or near Search Reset I accept AANP's Terms of Use Overall Focus All Primary ... practice site(s) to NP Finder, and enjoy many more member benefits.

  11. Find a Physical Therapist

    MedlinePlus

    ... Patients Choosing Your PT Preparing For a Visit Insurance Information Advocacy Visiting a PT What you need to know before your appointment with your physical therapist. Go There » Find a PT For Health Professionals ... ...

  12. Find a Dentist

    MedlinePlus

    ... information you need from the Academy of General Dentistry Tuesday, October 4, 2016 About | Contact Find an ... more. Disclaimer of Liabilities The Academy of General Dentistry's (AGD) Web site provides a listing of members ...

  13. Find a Therapist

    MedlinePlus

    ... Facts Find Help News and Research Tips for Soldiers and Veterans Tips for Families and Friends Take ... questions to ask for yourself and for your child . If we can be of further assistance Contact ...

  14. Find a Doctor

    MedlinePlus

    ... Doctor Finding a doctor with special training in movement disorders can make a big difference in your ... Goldstein Goldstone Gollomp Goodman Gorman Gottschalk Graff Greeley Green Gregory Griffith Grill Grillone Grist Grossman Groves Gudesblatt ...

  15. Finding the engram.

    PubMed

    Josselyn, Sheena A; Köhler, Stefan; Frankland, Paul W

    2015-09-01

    Many attempts have been made to localize the physical trace of a memory, or engram, in the brain. However, until recently, engrams have remained largely elusive. In this Review, we develop four defining criteria that enable us to critically assess the recent progress that has been made towards finding the engram. Recent 'capture' studies use novel approaches to tag populations of neurons that are active during memory encoding, thereby allowing these engram-associated neurons to be manipulated at later times. We propose that findings from these capture studies represent considerable progress in allowing us to observe, erase and express the engram. PMID:26289572

  16. Tooth Tutoring: The Findings.

    ERIC Educational Resources Information Center

    Cone, Richard; And Others

    Findings are reported on a three year cross-age tutoring program in which undergraduate dental hygiene students and college students from other disciplines trained upper elementary students to tutor younger students in the techniques of dental hygiene. Data includes pre-post scores on the Oral Hygiene Index of plaque for both experimental and…

  17. Finding Health Care Services

    Cancer.gov

    If you have been diagnosed with cancer, finding a doctor and treatment facility for your cancer care is an important step to getting the best treatment possible. Learn tips for choosing a doctor and treatment facility to manage your cancer care.

  18. Sonographic Findings of Hydropneumothorax.

    PubMed

    Nations, Joel Anthony; Smith, Patrick; Parrish, Scott; Browning, Robert

    2016-09-01

    Ultrasound is increasingly being used in examination of the thorax. The sonographic features of normal aerated lung, abnormal lung, pneumothorax, and intrapleural fluid have been published. The sonographic features of uncommon intrathoracic syndromes are less known. Hydropneumothorax is an uncommon process in which the thoracic cavity contains both intrapleural air and water. Few published examples of the sonographic findings in hydropneumothorax exist. We present 3 illustrative cases of the sonographic features of hydropneumothorax with comparative imaging and a literature review of the topic. PMID:27556194

  19. Finding an Eye Care Professional

    MedlinePlus

    ... Information > Finding an Eye Care Professional Finding an Eye Care Professional Finding an Eye Care Professional PDF* The National Eye Institute does not provide referrals or recommend specific ...

  20. Working with Generation X physicians.

    PubMed

    Shields, Mark C; Shields, Margaux T

    2003-01-01

    Learn ways to integrate Generation X physicians into your hospital or practice. Discover how their career goals differ from the earlier generation's and find out how health care organizations can help meet those goals.

  1. Finding the Next Earth

    NASA Astrophysics Data System (ADS)

    Batalha, Natalie M.; Kepler Team

    2013-01-01

    Twenty years ago, we knew of no planets orbiting other Sun-like stars, yet today, the roll call is nearly 1,000 strong. Statistical studies of exoplanet populations are possible, and words like "habitable zone" are heard around the dinner table. Theorists are scrambling to explain not only the observed physical characteristics but also the orbital and dynamical properties of planetary systems. The taxonomy is diverse but still reflects the observational biases that dominate the detection surveys. We've yet to find another planet that looks anything like home. The scene changed dramatically with the launch of the Kepler spacecraft in 2009 to determine, via transit photometry, the fraction of stars harboring earth-size planets in or near the Habitable Zone of their parent star. Early catalog releases hint that nature makes small planets efficiently: over half of the sample of 2,300 planet candidates discovered in the first two years are smaller than 2.5 times the Earth's radius. I will describe Kepler's milestone discoveries and progress toward an exo-Earth census. Humankind's speculation about the existence of other worlds like our own has become a veritable quest.

  2. Thoracic textilomas: CT findings*

    PubMed Central

    Machado, Dianne Melo; Zanetti, Gláucia; Araujo, Cesar Augusto; Nobre, Luiz Felipe; Meirelles, Gustavo de Souza Portes; Pereira e Silva, Jorge Luiz; Guimarães, Marcos Duarte; Escuissato, Dante Luiz; Souza, Arthur Soares; Hochhegger, Bruno; Marchiori, Edson

    2014-01-01

    OBJECTIVE: The aim of this study was to analyze chest CT scans of patients with thoracic textiloma. METHODS: This was a retrospective study of 16 patients (11 men and 5 women) with surgically confirmed thoracic textiloma. The chest CT scans of those patients were evaluated by two independent observers, and discordant results were resolved by consensus. RESULTS: The majority (62.5%) of the textilomas were caused by previous heart surgery. The most common symptoms were chest pain (in 68.75%) and cough (in 56.25%). In all cases, the main tomographic finding was a mass with regular contours and borders that were well-defined or partially defined. Half of the textilomas occurred in the right hemithorax and half occurred in the left. The majority (56.25%) were located in the lower third of the lung. The diameter of the mass was ≤ 10 cm in 10 cases (62.5%) and > 10 cm in the remaining 6 cases (37.5%). Most (81.25%) of the textilomas were heterogeneous in density, with signs of calcification, gas, radiopaque marker, or sponge-like material. Peripheral expansion of the mass was observed in 12 (92.3%) of the 13 patients in whom a contrast agent was used. Intraoperatively, pleural involvement was observed in 14 cases (87.5%) and pericardial involvement was observed in 2 (12.5%). CONCLUSIONS: It is important to recognize the main tomographic aspects of thoracic textilomas in order to include this possibility in the differential diagnosis of chest pain and cough in patients with a history of heart or thoracic surgery, thus promoting the early identification and treatment of this postoperative complication. PMID:25410842

  3. Generational diversity.

    PubMed

    Kramer, Linda W

    2010-01-01

    Generational diversity has proven challenges for nurse leaders, and generational values may influence ideas about work and career planning. This article discusses generational gaps, influencing factors and support, and the various generational groups present in today's workplace as well as the consequences of need addressing these issues. The article ends with a discussion of possible solutions.

  4. Generational diversity.

    PubMed

    Kramer, Linda W

    2010-01-01

    Generational diversity has proven challenges for nurse leaders, and generational values may influence ideas about work and career planning. This article discusses generational gaps, influencing factors and support, and the various generational groups present in today's workplace as well as the consequences of need addressing these issues. The article ends with a discussion of possible solutions. PMID:20395729

  5. Immunological findings in autism.

    PubMed

    Cohly, Hari Har Parshad; Panja, Asit

    2005-01-01

    elevated in autistic brains. In measles virus infection, it has been postulated that there is immune suppression by inhibiting T-cell proliferation and maturation and downregulation MHC class II expression. Cytokine alteration of TNF-alpha is increased in autistic populations. Toll-like-receptors are also involved in autistic development. High NO levels are associated with autism. Maternal antibodies may trigger autism as a mechanism of autoimmunity. MMR vaccination may increase risk for autism via an autoimmune mechanism in autism. MMR antibodies are significantly higher in autistic children as compared to normal children, supporting a role of MMR in autism. Autoantibodies (IgG isotype) to neuron-axon filament protein (NAFP) and glial fibrillary acidic protein (GFAP) are significantly increased in autistic patients (Singh et al., 1997). Increase in Th2 may explain the increased autoimmunity, such as the findings of antibodies to MBP and neuronal axonal filaments in the brain. There is further evidence that there are other participants in the autoimmune phenomenon. (Kozlovskaia et al., 2000). The possibility of its involvement in autism cannot be ruled out. Further investigations at immunological, cellular, molecular, and genetic levels will allow researchers to continue to unravel the immunopathogenic mechanisms' associated with autistic processes in the developing brain. This may open up new avenues for prevention and/or cure of this devastating neurodevelopmental disorder.

  6. Findings.

    ERIC Educational Resources Information Center

    Viadero, Debra; Coles, Adrienne D.

    1998-01-01

    Studies on race-based admissions, sports and sex, and religion and drugs suggest that: affirmative action policies were successful regarding college admissions; boys who play sports are more likely to be sexually active than their peers, with the opposite true for girls; and religion is a major factor in whether teens use cigarettes, alcohol, and…

  7. Regional Transmission Projects: Finding Solutions

    SciTech Connect

    The Keystone Center

    2005-06-15

    The Keystone Center convened and facilitated a year-long Dialogue on "Regional Transmission Projects: Finding Solutions" to develop recommendations that will help address the difficult and contentious issues related to expansions of regional electric transmission systems that are needed for reliable and economic transmission of power within and across regions. This effort brought together a cross-section of affected stakeholders and thought leaders to address the problem with the collective wisdom of their experience and interests. Transmission owners sat at the table with consumer advocates and environmental organizations. Representatives from regional transmission organizations exchanged ideas with state and federal regulators. Generation developers explored common interests with public power suppliers. Together, the Dialogue participants developed consensus solutions about how to begin unraveling some of the more intractable issues surrounding identification of need, allocation of costs, and reaching consensus on siting issues that can frustrate the development of regional transmission infrastructure. The recommendations fall into three broad categories: 1. Recommendations on appropriate institutional arrangements and processes for achieving regional consensus on the need for new or expanded transmission infrastructure 2. Recommendations on the process for siting of transmission lines 3. Recommendations on the tools needed to support regional planning, cost allocation, and siting efforts. List of Dialogue participants: List of Dialogue Participants: American Electric Power American Transmission Company American Wind Energy Association California ISO Calpine Corporation Cinergy Edison Electric Institute Environmental Defense Federal Energy Regulatory Commission Great River Energy International Transmission Company ISO-New England Iowa Public Utility Board Kanner & Associates Midwest ISO National Association of Regulatory Utility Commissioners National Association

  8. Wind Generators

    NASA Astrophysics Data System (ADS)

    1989-01-01

    When Enerpro, Inc. president, Frank J. Bourbeau, attempted to file a patent on a system for synchronizing a wind generator to the electric utility grid, he discovered Marshall Space Flight Center's Frank Nola's power factor controller. Bourbeau advanced the technology and received a NASA license and a patent for his Auto Synchronous Controller (ASC). The ASC reduces generator "inrush current," which occurs when large generators are abruptly brought on line. It controls voltage so the generator is smoothly connected to the utility grid when it reaches its synchronous speed, protecting the components from inrush current damage. Generator efficiency is also increased in light winds by applying lower than rated voltage. Wind energy is utilized to drive turbines to generate electricity for utility companies.

  9. Going Local to Find Help

    MedlinePlus

    ... Home Current Issue Past Issues Cover Story: Traumatic Brain Injury Going Local to Find Help Past Issues / Fall ... the time. From the MedlinePlus page on Traumatic Brain Injury, you can use Go Local to find specific ...

  10. Lupus Nephritis: An Overview of Recent Findings

    PubMed Central

    de Zubiria Salgado, Alberto; Herrera-Diaz, Catalina

    2012-01-01

    Lupus nephritis (LN) is one of the most serious complications of systemic lupus erythematosus (SLE) since it is the major predictor of poor prognosis. In susceptible individuals suffering of SLE, in situ formation and deposit of immune complexes (ICs) from apoptotic bodies occur in the kidneys as a result of an amplified epitope immunological response. IC glomerular deposits generate release of proinflammatory cytokines and cell adhesion molecules causing inflammation. This leads to monocytes and polymorphonuclear cells chemotaxis. Subsequent release of proteases generates endothelial injury and mesangial proliferation. Presence of ICs promotes adaptive immune response and causes dendritic cells to release type I interferon. This induces maturation and activation of infiltrating T cells, and amplification of Th2, Th1 and Th17 lymphocytes. Each of them, amplify B cells and activates macrophages to release more proinflammatory molecules, generating effector cells that cannot be modulated promoting kidney epithelial proliferation and fibrosis. Herein immunopathological findings of LN are reviewed. PMID:22536486

  11. Generative Semantics

    ERIC Educational Resources Information Center

    Bagha, Karim Nazari

    2011-01-01

    Generative semantics is (or perhaps was) a research program within linguistics, initiated by the work of George Lakoff, John R. Ross, Paul Postal and later McCawley. The approach developed out of transformational generative grammar in the mid 1960s, but stood largely in opposition to work by Noam Chomsky and his students. The nature and genesis of…

  12. Generative Semantics.

    ERIC Educational Resources Information Center

    King, Margaret

    The first section of this paper deals with the attempts within the framework of transformational grammar to make semantics a systematic part of linguistic description, and outlines the characteristics of the generative semantics position. The second section takes a critical look at generative semantics in its later manifestations, and makes a case…

  13. The New Second Generation.

    ERIC Educational Resources Information Center

    Portes, Alejandro, Ed.

    This book compiles findings on the children of recent immigrants to the United States. The dearth of accessible census data and the tendency for school records and scholarly surveys to compress second-generation youth into a classificatory scheme that obliterates their history have obscured a major phenomenon in U.S. society--a rapidly growing…

  14. Energy generator

    SciTech Connect

    Krisko, P.

    1989-08-01

    The patent describes a power booster. It comprises: at least one pendulum means suspended at one end to oscillate about the point of suspension; power generating means; mass means connected to one end of the pendulum means; spring means disposed in operative cooperation with the mass means to impart energy into the pendulum means and assist the pendulum means in oscillating about the point of suspension; and energy transfer linkage means between the pendulum means and the power generating means for transferring energy between the pendulum means and the power generating means.

  15. Generation Wrecked.

    ERIC Educational Resources Information Center

    Watson, Noshua

    2002-01-01

    Young adults in Generation X are facing financial problems. Because of their college and credit card debt, many in worse financial shape than anyone since the Depression and have little or no retirement savings. (JOW)

  16. Thermoelectric Generator

    NASA Technical Reports Server (NTRS)

    Cole, T.

    1985-01-01

    Small modular alkali metal thermoelectric generator with no moving parts directly converts heat to electrical energy with efficiency of 20 to 40 percent. Unit uses closed regenerative electrochemical concentration cell based on sodium-ion conductor beta alumina.

  17. Finding Areas on Dot Paper

    ERIC Educational Resources Information Center

    Pagni, David L.

    2007-01-01

    This article contains investigative activities to assist students in constructing formulas out of an understanding of the area of geometric shapes. Included with this article are a "Finding Areas on Square Dot Paper Activity Sheet" and a "Finding Areas on Triangle Dot Paper Activity Sheet." (Contains 1 table and 11 figures.)

  18. Finding the object'' proceedings addendum

    SciTech Connect

    Whiting, M.A.; Devaney, D.M.

    1990-10-01

    The purpose of this workshop was to discuss finding the object -- that is, how software engineers imagine, invent, design, or recycle objects and their behaviors for object-oriented software engineering. The workshop organizers (and, as we subsequently discovered, several of the workshop participants) felt that this issue is crucial to successful object-oriented software engineering (after all, finding objects is what the projects is all about, isn't it ). Unfortunately, when previous workshops have had the opportunity to review and discuss techniques practitioners use to find objects, too often the results were heated debates on what is an object '' which becomes all consuming. We believed that, given appropriate control over the question of which kind of object'' is being discussed (which meant tell us what object you are trying to find, then tell us your method), a workshop to concentrate on techniques for finding objects would be quite appropriate. 8 refs., 2 figs.

  19. Microwave generator

    DOEpatents

    Kwan, T.J.T.; Snell, C.M.

    1987-03-31

    A microwave generator is provided for generating microwaves substantially from virtual cathode oscillation. Electrons are emitted from a cathode and accelerated to an anode which is spaced apart from the cathode. The anode has an annular slit there through effective to form the virtual cathode. The anode is at least one range thickness relative to electrons reflecting from the virtual cathode. A magnet is provided to produce an optimum magnetic field having the field strength effective to form an annular beam from the emitted electrons in substantial alignment with the annular anode slit. The magnetic field, however, does permit the reflected electrons to axially diverge from the annular beam. The reflected electrons are absorbed by the anode in returning to the real cathode, such that substantially no reflexing electrons occur. The resulting microwaves are produced with a single dominant mode and are substantially monochromatic relative to conventional virtual cathode microwave generators. 6 figs.

  20. PULSE GENERATOR

    DOEpatents

    Roeschke, C.W.

    1957-09-24

    An improvement in pulse generators is described by which there are produced pulses of a duration from about 1 to 10 microseconds with a truly flat top and extremely rapid rise and fall. The pulses are produced by triggering from a separate input or by modifying the current to operate as a free-running pulse generator. In its broad aspect, the disclosed pulse generator comprises a first tube with an anode capacitor and grid circuit which controls the firing; a second tube series connected in the cathode circuit of the first tube such that discharge of the first tube places a voltage across it as the leading edge of the desired pulse; and an integrator circuit from the plate across the grid of the second tube to control the discharge time of the second tube, determining the pulse length.

  1. PACS: effect on incidental findings.

    PubMed

    Green, Larissa

    2004-01-01

    Previous studies have addressed the increased volume of incidental findings when interpreting MRI lumbar spine studies after the implementation of a picture archiving and communication system (PACS). The purpose of this study is to confirm prior findings and contribute additional knowledge that supports the use of technology in complimenting the quality of patient care. Lumbar spine interpretations were reprinted from 900 studies and individually reviewed. These lumbar spine studies were performed on a 1.5-tesla magnet. Included were 300 consecutive lumbar spine reports over a two year period: four months prior to PACS introduction, four months during the transition to PACS, and four months post PACS implementation. Reports stating incidental findings were tabulated, along with the frequency patient gender, age, location (outpatient, inpatient or emergency room), reporting radiologist, specific finding and radiologist recommendations in each case were documented. The number of incidental findings increased from five pre-PACS to nine during the transition phase to PACS, followed by 11 post-PACS. This results in a maximum increase of 120 percent from pre- to post-PACS. The most common incidental findings include renal mass, cyst or lesions, aortic aneurysms and lymph node abnormalities. Statistical data confirms that the implementation of PACS into a radiology practice for MRI lumbar spine imaging appears to have a beneficial impact on the number of reported incidental findings and recommended follow-up studies.

  2. Stochastic Generator of Chemical Structure. 3. Reaction Network Generation

    SciTech Connect

    FAULON,JEAN-LOUP; SAULT,ALLEN G.

    2000-07-15

    A new method to generate chemical reaction network is proposed. The particularity of the method is that network generation and mechanism reduction are performed simultaneously using sampling techniques. Our method is tested for hydrocarbon thermal cracking. Results and theoretical arguments demonstrate that our method scales in polynomial time while other deterministic network generator scale in exponential time. This finding offers the possibility to investigate complex reacting systems such as those studied in petroleum refining and combustion.

  3. Visual direction finding by fishes

    NASA Technical Reports Server (NTRS)

    Waterman, T. H.

    1972-01-01

    The use of visual orientation, in the absence of landmarks, for underwater direction finding exercises by fishes is reviewed. Celestial directional clues observed directly near the water surface or indirectly at an asymptatic depth are suggested as possible orientation aids.

  4. Find a NCCAOM Certified Practitioner

    MedlinePlus

    ... NCCAOM Certification Get Certified Get Recertified PDA Search Engine Find A Practitioner State Licensing Helpful NCCAOM Links ... My Status State Licensure Diplomates Recertification PDA Search Engine State Licensure Consumers Diplomate of Acupuncture Diplomate of ...

  5. Radiographic findings in liveborn triploidy.

    PubMed

    Silverthorn, K G; Houston, C S; Newman, D E; Wood, B J

    1989-01-01

    The detailed radiographic features of triploidy, a fatal congenital disorder with 69 chromosomes, have not previously been reported. Radiographs of ten liveborn infants with chromosomally confirmed triploidy showed six findings highly suggestive of this diagnosis: harlequin orbits, small anterior fontanelle, gracile ribs, diaphyseal overtubulation of long bones, upswept clavicles and antimongoloid pelvis. Sixteen other less specific findings showed many similarities to those found in trisomy 18.

  6. Smoke generator

    NASA Technical Reports Server (NTRS)

    Parrish, K. L.

    1973-01-01

    Generator is simple in construction, efficient, and extremely easy to start and regulate. It can be of such small size and weight that it can be installed easily inside a model. Size can be changed to suit needs, as long as operating temperatures can be attained and identified controls are utilized.

  7. Generation Next

    ERIC Educational Resources Information Center

    Hawkins, B. Denise

    2010-01-01

    There is a shortage of accounting professors with Ph.D.s who can prepare the next generation. To help reverse the faculty deficit, the American Institute of Certified Public Accountants (CPAs) has created the new Accounting Doctoral Scholars program by pooling more than $17 million and soliciting commitments from more than 70 of the nation's…

  8. Knee bone tumors: findings on conventional radiology.

    PubMed

    Andrade Neto, Francisco; Teixeira, Manuel Joaquim Diógenes; Araújo, Leonardo Heráclio do Carmo; Ponte, Carlos Eduardo Barbosa

    2016-01-01

    The knee is a common site for bone tumors, whether clinically painful or not. Conventional radiology has been established as the first line of investigation in patients with knee pain and can reveal lesions that often generate questions not only for the generalist physician but also for the radiologist or general orthopedist. History, image examination, and histopathological analysis compose the essential tripod of the diagnosis of bone tumors, and conventional radiology is an essential diagnostic tool in patients with knee pain. This pictorial essay proposes to depict the main conventional radiography findings of the most common bone tumors around the knee, including benign and malignant tumors, as well as pseudo-tumors.

  9. Next generation sequencing (NGS)technologies and applications

    SciTech Connect

    Vuyisich, Momchilo

    2012-09-11

    NGS technology overview: (1) NGS library preparation - Nucleic acids extraction, Sample quality control, RNA conversion to cDNA, Addition of sequencing adapters, Quality control of library; (2) Sequencing - Clonal amplification of library fragments, (except PacBio), Sequencing by synthesis, Data output (reads and quality); and (3) Data analysis - Read mapping, Genome assembly, Gene expression, Operon structure, sRNA discovery, and Epigenetic analyses.

  10. Magnetocumulative generator

    DOEpatents

    Pettibone, J.S.; Wheeler, P.C.

    1981-06-08

    An improved magnetocumulative generator is described that is useful for producing magnetic fields of very high energy content over large spatial volumes. The polar directed pleated magnetocumulative generator has a housing providing a housing chamber with an electrically conducting surface. The chamber forms a coaxial system having a small radius portion and a large radius portion. When a magnetic field is injected into the chamber, from an external source, most of the magnetic flux associated therewith positions itself in the small radius portion. The propagation of an explosive detonation through high-explosive layers disposed adjacent to the housing causes a phased closure of the chamber which sweeps most of the magnetic flux into the large radius portion of the coaxial system. The energy content of the magnetic field is greatly increased by flux stretching as well as by flux compression. The energy enhanced magnetic field is utilized within the housing chamber itself.

  11. Finding the Future That Fits.

    ERIC Educational Resources Information Center

    Taylor, Alison

    In 2000, a government-supported foundation called Careers the Next Generation (CNG) in Alberta, Canada, began coordinating summer internships for high school students in information and computer technology (ICT). The participating firms represented a mix of large and small private and public organizations in high-tech and other industries in the…

  12. Cluster generator

    DOEpatents

    Donchev, Todor I.; Petrov, Ivan G.

    2011-05-31

    Described herein is an apparatus and a method for producing atom clusters based on a gas discharge within a hollow cathode. The hollow cathode includes one or more walls. The one or more walls define a sputtering chamber within the hollow cathode and include a material to be sputtered. A hollow anode is positioned at an end of the sputtering chamber, and atom clusters are formed when a gas discharge is generated between the hollow anode and the hollow cathode.

  13. PLASMA GENERATOR

    DOEpatents

    Foster, J.S. Jr.

    1958-03-11

    This patent describes apparatus for producing an electricity neutral ionized gas discharge, termed a plasma, substantially free from contamination with neutral gas particles. The plasma generator of the present invention comprises a plasma chamber wherein gas introduced into the chamber is ionized by a radiofrequency source. A magnetic field is used to focus the plasma in line with an exit. This magnetic field cooperates with a differential pressure created across the exit to draw a uniform and uncontaminated plasma from the plasma chamber.

  14. Thermoelectric generator

    DOEpatents

    Pryslak, N.E.

    1974-02-26

    A thermoelectric generator having a rigid coupling or stack'' between the heat source and the hot strap joining the thermoelements is described. The stack includes a member of an insulating material, such as ceramic, for electrically isolating the thermoelements from the heat source, and a pair of members of a ductile material, such as gold, one each on each side of the insulating member, to absorb thermal differential expansion stresses in the stack. (Official Gazette)

  15. Photon generator

    DOEpatents

    Srinivasan-Rao, Triveni

    2002-01-01

    A photon generator includes an electron gun for emitting an electron beam, a laser for emitting a laser beam, and an interaction ring wherein the laser beam repetitively collides with the electron beam for emitting a high energy photon beam therefrom in the exemplary form of x-rays. The interaction ring is a closed loop, sized and configured for circulating the electron beam with a period substantially equal to the period of the laser beam pulses for effecting repetitive collisions.

  16. Electric generator

    DOEpatents

    Foster, Jr., John S.; Wilson, James R.; McDonald, Jr., Charles A.

    1983-01-01

    1. In an electrical energy generator, the combination comprising a first elongated annular electrical current conductor having at least one bare surface extending longitudinally and facing radially inwards therein, a second elongated annular electrical current conductor disposed coaxially within said first conductor and having an outer bare surface area extending longitudinally and facing said bare surface of said first conductor, the contiguous coaxial areas of said first and second conductors defining an inductive element, means for applying an electrical current to at least one of said conductors for generating a magnetic field encompassing said inductive element, and explosive charge means disposed concentrically with respect to said conductors including at least the area of said inductive element, said explosive charge means including means disposed to initiate an explosive wave front in said explosive advancing longitudinally along said inductive element, said wave front being effective to progressively deform at least one of said conductors to bring said bare surfaces thereof into electrically conductive contact to progressively reduce the inductance of the inductive element defined by said conductors and transferring explosive energy to said magnetic field effective to generate an electrical potential between undeformed portions of said conductors ahead of said explosive wave front.

  17. Scintigraphic findings in ankylosing spondylitis.

    PubMed

    Lentle, B C; Russell, A S; Percy, J S; Jackson, F I

    1977-06-01

    A prospective study of bone scintigraphic findings has been carried out in 63 patients, firmly diagnosed as having ankylosing spondylitis. In addition to abnormal uptake of the radiotracer at the sacroiliac joints, a peripheral arthropathy has been a common finding, particularly in the proximal joints, occurring in up to 50% of patients. Increased uptake of radiotracer in the spine has also been found both diffusely and focally. Focal increases have been noted at the apophyseal joints in 40% of patients and in three patients with a sterile intervertebral diskitis, an unusual complication of this disease only diagnosed in two patients after bone scintigraphy.

  18. Peak finding using biorthogonal wavelets

    SciTech Connect

    Tan, C.Y.

    2000-02-01

    The authors show in this paper how they can find the peaks in the input data if the underlying signal is a sum of Lorentzians. In order to project the data into a space of Lorentzian like functions, they show explicitly the construction of scaling functions which look like Lorentzians. From this construction, they can calculate the biorthogonal filter coefficients for both the analysis and synthesis functions. They then compare their biorthogonal wavelets to the FBI (Federal Bureau of Investigations) wavelets when used for peak finding in noisy data. They will show that in this instance, their filters perform much better than the FBI wavelets.

  19. CT findings of atrial myxoma

    SciTech Connect

    Tsuchiya, F.; Kohno, A.; Saitoh, R.; Shigeta, A.

    1984-04-01

    The computed tomographic (CT) appearance of six atrial myxomas was analyzed. Five of the myxomas were located in the left atrium and one was in the right atrium. The margin of the myxoma was at least slightly lobulated in five cases and the content was inhomogeneous in all. Calcification was demonstrated in three cases. The site of attachment of the myxoma was demonstrated by CT to be the arial septum in all cases. The CT finding correlated well with the operative findings. It is concluded that it is possible with CT to diagnose atrial myxoma by the location and nature of the intracardiac mass and to differentiate it from thrombus.

  20. Neurological findings of Lyme disease.

    PubMed Central

    Pachner, A. R.; Steere, A. C.

    1984-01-01

    Neurologic involvement of Lyme disease typically consists of meningitis, cranial neuropathy, and radiculoneuritis, alone or in combination, lasting for months. From 1976 to 1983, we studied 38 patients with Lyme meningitis. Headache and mild neck stiffness, which fluctuated in intensity, and lymphocytic pleocytosis were the common findings. Half of the patients also had facial palsies, which were unilateral in 12 and bilateral in seven. In addition, 12 patients had motor and/or sensory radiculoneuropathies; asymmetric weakness of extremities was the most common finding. Although incomplete presentations of neurologic involvement of Lyme disease may be confused with other entities, the typical constellation of neurologic symptoms represents a unique clinical picture. PMID:6516450

  1. Finding Geography Using Found Poetry

    ERIC Educational Resources Information Center

    Foster, Ellen J.

    2012-01-01

    Functional literacy is important in both English/language arts and geography. Using the "found poetry" strategy, students will summarize a piece of text, identify main ideas and find geographic connections. While using young adult literature is a great way to incorporate geography into English/language arts classroom, understanding of geography…

  2. MEMS AO for Planet Finding

    NASA Technical Reports Server (NTRS)

    Rao, Shanti; Wallace, J. Kent; Shao, Mike; Schmidtlin, Edouard; Levine, B. Martin; Samuele, Rocco; Lane, Benjamin; Chakrabarti, Supriya; Cook, Timothy; Hicks, Brian; Jung, Paul

    2008-01-01

    This slide presentation reviews a method for planet finding using microelectromechanical systems (MEMS) Adaptive Optics (AO). The use of a deformable mirror (DM) is described as a part of the instrument that was designed with a nulling interferometer. The strategy that is used is described in detail.

  3. Writing audit findings: Be reasonable

    SciTech Connect

    Girvin, N.W.

    1992-05-01

    A customary approach to auditing and reporting deficiencies is to keep a running list of those that are found, evaluate the severity of each, and based on the evidence, document findings or observations or concerns in an audit report. The report is issued and the auditee is normally requested to address root cause'' as part of their corrective action. This paper describes a root problems'' approach to documenting audit findings that is designed not only to put the QA auditor in a more favorable light, but to more effectively enable the auditee to identify root cause and meaningful corrective action. The positive results of this approach are considerable. You will have fewer findings but those you do have will be substantial. You will cite requirements that sound reasonable and make arguments difficult. If some of the supporting deficiencies (examples) prove to be incorrect, you will still have ample support for the original finding. You will be seen as reasonable individual who can help lead the auditee towards identification of root cause without taking away part of the responsibility. You even have a fair chance of fostering a sense of commitment to quality improvement on the auditee's part. This in itself, is its own reward.

  4. Writing audit findings: Be reasonable!

    SciTech Connect

    Girvin, N.W.

    1992-05-01

    A customary approach to auditing and reporting deficiencies is to keep a running list of those that are found, evaluate the severity of each, and based on the evidence, document findings or observations or concerns in an audit report. The report is issued and the auditee is normally requested to address ``root cause`` as part of their corrective action. This paper describes a ``root problems`` approach to documenting audit findings that is designed not only to put the QA auditor in a more favorable light, but to more effectively enable the auditee to identify root cause and meaningful corrective action. The positive results of this approach are considerable. You will have fewer findings but those you do have will be substantial. You will cite requirements that sound reasonable and make arguments difficult. If some of the supporting deficiencies (examples) prove to be incorrect, you will still have ample support for the original finding. You will be seen as reasonable individual who can help lead the auditee towards identification of root cause without taking away part of the responsibility. You even have a fair chance of fostering a sense of commitment to quality improvement on the auditee`s part. This in itself, is its own reward.

  5. 1980-1981 Evaluation Findings.

    ERIC Educational Resources Information Center

    Austin Independent School District, TX. Office of Research and Evaluation.

    This volume summarizes the results of evaluation and testing activities carried out in the Austin, Texas, Independent School District (AISD) during the 1980-81 school year. The text consists of five parts: Section one highlights important findings in the areas of Title I Schoolwide Projects, compensatory programs, early childhood programs,…

  6. Finding Cryptography in Object Code

    SciTech Connect

    Jason L. Wright

    2008-10-01

    Finding and identifying Cryptography is a growing concern in the malware analysis community. In this paper, a heuristic method for determining the likelihood that a given function contains a cryptographic algorithm is discussed and the results of applying this method in various environments is shown. The algorithm is based on frequency analysis of opcodes that make up each function within a binary.

  7. Organizing pneumonia: chest HRCT findings*

    PubMed Central

    Faria, Igor Murad; Zanetti, Gláucia; Barreto, Miriam Menna; Rodrigues, Rosana Souza; Araujo-Neto, Cesar Augusto; Silva, Jorge Luiz Pereira e; Escuissato, Dante Luiz; Souza, Arthur Soares; Irion, Klaus Loureiro; Mançano, Alexandre Dias; Nobre, Luiz Felipe; Hochhegger, Bruno; Marchiori, Edson

    2015-01-01

    OBJECTIVE: To determine the frequency of HRCT findings and their distribution in the lung parenchyma of patients with organizing pneumonia. METHODS: This was a retrospective review of the HRCT scans of 36 adult patients (26 females and 10 males) with biopsy-proven organizing pneumonia. The patients were between 19 and 82 years of age (mean age, 56.2 years). The HRCT images were evaluated by two independent observers, discordant interpretations being resolved by consensus. RESULTS: The most common HRCT finding was that of ground-glass opacities, which were seen in 88.9% of the cases. The second most common finding was consolidation (in 83.3% of cases), followed by peribronchovascular opacities (in 52.8%), reticulation (in 38.9%), bronchiectasis (in 33.3%), interstitial nodules (in 27.8%), interlobular septal thickening (in 27.8%), perilobular pattern (in 22.2%), the reversed halo sign (in 16.7%), airspace nodules (in 11.1%), and the halo sign (in 8.3%). The lesions were predominantly bilateral, the middle and lower lung fields being the areas most commonly affected. CONCLUSIONS: Ground-glass opacities and consolidation were the most common findings, with a predominantly random distribution, although they were more common in the middle and lower thirds of the lungs. PMID:26176521

  8. Finding Diamonds in the Rough

    NASA Technical Reports Server (NTRS)

    2000-01-01

    HighTower Software, Inc. has developed a commercial software application originally designed at JPL that helps users identify deviations from norms out of massive quantities of data. The commercial product is known as CyberGrid and the same software is still supporting NASA's Voyager, Galileo and Cassini missions. CyberGrid generates 3-D graphs of data and has been used in AIDS research as well as e-commerce applications.

  9. Tide generator

    SciTech Connect

    Feltenberger, B.D.

    1981-06-16

    A tidewater power system consisting of a high tide reservoir and a low tide reservoir. The high tide reservoir has an inlet adapted to be supported at high tide level and an outlet with a water wheel and generator between the outlet of the high tide reservoir and the low tide reservoir. The low tide reservoir has an outlet at the low tide level. The outlet from the high tide reservoir is adjustable to control the flow rate and the high tide reservoir can be closed at high tide to retain water for use over a period of time.

  10. Smoke generator

    NASA Technical Reports Server (NTRS)

    Rogers, J. R. (Inventor)

    1976-01-01

    A smoke generator is disclosed which is particularly suitable for mounting on the wing tips of an aircraft and for conducting airflow studies. The device includes a network of thermally insulated tubes for carrying a fluid which is used to produce smoke. The fluid, which need not be combustible, is heated above its vaporization temperature by electric current which is passed through the fluid conduit tubes, so that the tubes serve both as fluid conduits and resistance heating elements. Fluid supply and monitoring systems and electrical control systems are also disclosed.

  11. HEAT GENERATION

    DOEpatents

    Imhoff, D.H.; Harker, W.H.

    1963-12-01

    Heat is generated by the utilization of high energy neutrons produced as by nuclear reactions between hydrogen isotopes in a blanket zone containing lithium, a neutron moderator, and uranium and/or thorium effective to achieve multtplicatton of the high energy neutron. The rnultiplied and moderated neutrons produced react further with lithium-6 to produce tritium in the blanket. Thermal neutron fissionable materials are also produced and consumed in situ in the blanket zone. The heat produced by the aggregate of the various nuclear reactions is then withdrawn from the blanket zone to be used or otherwise disposed externally. (AEC)

  12. Piezoelectrostatic generator

    NASA Technical Reports Server (NTRS)

    Robertson, Glen A. (Inventor)

    1990-01-01

    A piezoelectrostatic generator includes a plurality of elongated piezoelectric elements having first and second ends, with the first ends fixedly mounted in a cylindrical housing and the second extending radially inwardly toward an axis. A shaft movable along the axis is connected to the inner ends of the elements to produce bending forces in piezoelectric strips within the elements. Each element includes a pair of strips mounted in surface contact and in electrical series to produce a potential upon bending. Electrodes spaced from the strips by a solid dielectric material act as capacitor plates to collect the potential charge.

  13. Magnetocumulative generator

    DOEpatents

    Pettibone, Joseph S.; Wheeler, Paul C.

    1983-01-01

    An improved magnetocumulative generator is described that is useful for producing magnetic fields of very high energy content over large spatial volumes. The polar directed pleated magnetocumulative generator has a housing (100, 101, 102, 103, 104, 105) providing a housing chamber (106) with an electrically conducting surface. The chamber (106) forms a coaxial system having a small radius portion and a large radius portion. When a magnetic field is injected into the chamber (106), from an external source, most of the magnetic flux associated therewith positions itself in the small radius portion. The propagation of an explosive detonation through high-explosive layers (107, 108) disposed adjacent to the housing causes a phased closure of the chamber (106) which sweeps most of the magnetic flux into the large radius portion of the coaxial system. The energy content of the magnetic field is greatly increased by flux stretching as well as by flux compression. The energy enhanced magnetic field is utilized within the housing chamber itself.

  14. [Empirical findings with arson offenders].

    PubMed

    Rechlin, T; Weis, M

    1992-11-01

    Forensic, psychological and psychopathological findings on 40 arsonists, who were investigated in our psychiatric department between 1980 and 1990, are presented. The findings indicate that arsonists represent a diagnostically heterogeneous group of offenders. On the other hand, some common psychodynamic patterns can be seen; in particular, a high degree of suicidal and autoaggressive behaviour. As reported by other authors, arsonists appear to suffer from a disorder of impulse control. A historical review illustrates that since the mid-19th century a purely psychopathological model of pyromania has been found unsatisfactory, and suggests that psychodynamic aspects should not be over-emphasized. Analysis of the different motivation and abnormalities of arsonists could render the term pyromania obsolete. This requires however a radical reappraisal of the significance of psychiatric diagnosis within an anthropological framework.

  15. [Typical findings of maltreated children].

    PubMed

    Rauch, E; Zinka, B; Schneider, K; Penning, R; Eisenmenger, W

    2006-06-15

    Childhood maltreatment manifests in a variety of forms and the underlying causes are manifold. In contrast to other offences involving physical injury, reporting behavior has, statistically speaking, remained unchanged. Patterns of injury must first be established and documented, and this involves a complete examination of the child's body. Depending on the constellation of findings, a radiological diagnosis is usually necessary. When all the findings have been collected, the further steps to be taken--where indicated a report to the police--must be discussed. All the evidence must be recorded, and photos obtained of all externally visible injuries before they fade. It is not the task of the physician to develop criminalistic ambitions, for example, by grilling (a parent) on the cause of the injuries. However, he/she has a duty to do everything necessary to protect the well-being of the child. PMID:16850804

  16. Radiological Findings of Michel Aplasia

    PubMed Central

    Umul, Ayse; Demirtas, Hakan; Celik, Ahmet Orhan

    2016-01-01

    Introduction: Congenital abnormalities of the inner ear is the most common cause of neurosensory hearing loss. Michel inner ear deformity is a rare developmental anomaly refers to the total aplasia of the inner ear. It is caused by developmental arrest of otic placode early during the third week of gestational age. Case report: We have discussed here that three year old girl diagnosed Michel aplasia with temporal bone computed tomography (CT) and temporal magnetic resonance imaging (MRI) findings. PMID:27482139

  17. Retroperitoneal bronchogenic cyst: MRI findings.

    PubMed

    Castro, R; Oliveira, M I; Fernandes, T; Madureira, A J

    2013-01-01

    The authors describe a case of a retroperitoneal bronchogenic cyst in a 36-year-old female. She presented with abdominal pain, nausea, and vomiting. An MRI scan revealed an 8 cm cystic lesion in the left upper retroperitoneum, with intermediate signal on T2-weighted images, high signal on T1 weighted images, and lack of internal enhancement after gadolinium. After laparoscopic excision, the histology findings were compatible with a bronchogenic cyst, which is extremely uncommon in the retroperitoneum.

  18. Ultrasound findings in retroperitoneal lymphangiomyomatosis.

    PubMed

    Di Matteo, A M; Luisetti, M; Brunetti, E; Filice, C

    1990-01-01

    A 44-year old female patient with pulmonary lymphangiomyomatosis was examined by standard abdominal sonography. A wide involvement of the retroperitoneal lymph nodes and vessels was found. The relevant sonographic features were enlarged lymph nodes, and multiple anechoic structures, irregular in shape, thin-walled, with intraluminal septa. The findings, which resembled active cysts or liquid-filled bowels, were diagnosed as multiple ectasic lymphatic vessels.

  19. CYSTOSCOPIC FINDINGS: A VIDEO TUTORIAL

    PubMed Central

    Lenherr, Sara M.; Crosby, Erin C.; Cameron, Anne P.

    2015-01-01

    Aim Cystoscopy is frequently performed by gynecologists to ensure ureteral patency and no bladder injury when performing concomitant gynecologic procedures. Generally there are no additional findings on cystoscopy, however, when abnormalities arise, they might require either observation or intervention. Our aim was to create a visual library of benign, malignant and foreign-body pathologies incidentally encountered on cystoscopy. Method Cystoscopic findings were videotaped at the time of routine surgical care. Per Institutional Review Board approval, individual consent was waived as the videos were de-identified and collected for educational purposes. Results Benign pathologies: squamous metaplasia, duplicated ureteral orifice, ureterocele, Hutch diverticulum, bladder trabeculation, urachal cyst, interstitial cystitis with and without Hunner’s lesion, endometriosis in the bladder, port-wine stain due to Klippel-Trenaunay-Weber syndrome, nephrogenic (mesonephric) metaplasia, and cystitis glandularis (intestinal metaplasia). Malignant pathologies: papillary urothelial neoplasm of low malignant potential (PUNLMP), carcinoma in situ (CIS), high grade urothelial carcinoma, and urachal cancer. Foreign-body pathologies: edema from ureteral stents and stone encrusted mesh. Conclusion This video is intended to educate the audience on some incidental bladder findings seen on female cystoscopy. Many pathologies can be biopsied or treated immediately during the procedure hence early urology consultation for most abnormalities is encouraged. PMID:25619539

  20. PLASMA GENERATOR

    DOEpatents

    Wilcox, J.M.; Baker, W.R.

    1963-09-17

    This invention is a magnetohydrodynamic device for generating a highly ionized ion-electron plasma at a region remote from electrodes and structural members, thus avoiding contamination of the plasma. The apparatus utilizes a closed, gas-filled, cylindrical housing in which an axially directed magnetic field is provided. At one end of the housing, a short cylindrical electrode is disposed coaxially around a short axial inner electrode. A radial electrical discharge is caused to occur between the inner and outer electrodes, creating a rotating hydromagnetic ionization wave that propagates aiong the magnetic field lines toward the opposite end of the housing. A shorting switch connected between the electrodes prevents the wave from striking the opposite end of the housing. (AEC)

  1. Triboelectric generator

    DOEpatents

    Wang, Zhong L; Fan, Fengru; Lin, Long; Zhu, Guang; Pan, Caofeng; Zhou, Yusheng

    2015-11-03

    A generator includes a thin first contact charging layer and a thin second contact charging layer. The thin first contact charging layer includes a first material that has a first rating on a triboelectric series. The thin first contact charging layer has a first side with a first conductive electrode applied thereto and an opposite second side. The thin second contact charging layer includes a second material that has a second rating on a triboelectric series that is more negative than the first rating. The thin first contact charging layer has a first side with a first conductive electrode applied thereto and an opposite second side. The thin second contact charging layer is disposed adjacent to the first contact charging layer so that the second side of the second contact charging layer is in contact with the second side of the first contact charging layer.

  2. [The chest CT findings and pathologic findings of pulmonary tuberculosis].

    PubMed

    Ogata, Hideo

    2009-08-01

    The past research of the radiologic manifestations of pulmonary tuberculosis in Japan was based on morphological pathology of the untreated patient autopsy. I would like to show the chest CT scan of tuberculosis diseases with caseous granuloma at its exudative reaction, proliferative reaction, productive reaction, cirrhotic reaction until self cure. This progress reflects the normal cell mediated immunological responses. Also I would like to show the cavitation of granuloma, which results from liquefaction of caseous materials during the course and results in the formation of the source of infection. And finally I would like to show the morphological differences of acinous lesion, acino-nodular lesion and caseous lobular pneumonia. These differences reflect the amount of bacilli disseminated in the peripheral parts under the lobules. In this study, I do not show old age cases and HIV positive cases, who do not form typical granuloma due to the decreased cell mediated immnunity and whose X ray findings are atypical.

  3. Electrocardiographic findings in pulmonary embolism.

    PubMed

    Boey, Elaine; Teo, Swee-Guan; Poh, Kian-Keong

    2015-10-01

    Pulmonary embolism (PE) poses a challenge to physicians, as it can be difficult to diagnose but results in significant mortality and morbidity in patients. Diagnosing PE requires an integrated approach using clinical findings, electrocardiography (ECG), blood investigations and imaging modalities. Abnormalities in ECG are common among patients with massive acute PE and can serve as a prognostic indicator. In this article, we describe the ECG presentations of two patients diagnosed with PE, and review the literature on the various types of ECG presentations and their role in predicting the prognosis of PE.

  4. A compilation of jet finding algorithms

    SciTech Connect

    Flaugher, B.; Meier, K.

    1992-12-31

    Technical descriptions of jet finding algorithms currently in use in p{anti p} collider experiments (CDF, UA1, UA2), e{sup +}e{sup {minus}} experiments and Monte-Carlo event generators (LUND programs, ISAJET) have been collected. For the hadron collider experiments, the clustering methods fall into two categories: cone algorithms and nearest-neighbor algorithms. In addition, UA2 has employed a combination of both methods for some analysis. While there are clearly differences between the cone and nearest-neighbor algorithms, the authors have found that there are also differences among the cone algorithms in the details of how the centroid of a cone cluster is located and how the E{sub T} and P{sub T} of the jet are defined. The most commonly used jet algorithm in electron-positron experiments is the JADE-type cluster algorithm. Five various incarnations of this approach have been described.

  5. Knee bone tumors: findings on conventional radiology*

    PubMed Central

    Andrade Neto, Francisco; Teixeira, Manuel Joaquim Diógenes; Araújo, Leonardo Heráclio do Carmo; Ponte, Carlos Eduardo Barbosa

    2016-01-01

    The knee is a common site for bone tumors, whether clinically painful or not. Conventional radiology has been established as the first line of investigation in patients with knee pain and can reveal lesions that often generate questions not only for the generalist physician but also for the radiologist or general orthopedist. History, image examination, and histopathological analysis compose the essential tripod of the diagnosis of bone tumors, and conventional radiology is an essential diagnostic tool in patients with knee pain. This pictorial essay proposes to depict the main conventional radiography findings of the most common bone tumors around the knee, including benign and malignant tumors, as well as pseudo-tumors. PMID:27403019

  6. Finding Translation in Stress Research

    PubMed Central

    Hariri, Ahmad R.; Holmes, Andrew

    2015-01-01

    In our ongoing efforts to advance understanding of human diseases, translational research across rodents and humans on stress-related mental disorders stands out as a field that is briskly producing discoveries that illuminate novel mechanisms of risk and pathophysiology. Here we offer a perspective on how a productive translational research dialogue between preclinical models and clinical studies of these disorders is being powered by an ever developing appreciation of the shared neural circuits and genetic architecture that moderate the response to stress across species. Working from these deep foundations, we discuss the approaches, both traditional and innovative, which have the potential to deliver a new generation of risk-biomarkers and therapeutic strategies for stress-related disorders. PMID:26404709

  7. Wind generator

    SciTech Connect

    Wurtz, F.R.

    1980-01-29

    A wind operated generator is disclosed herein having a stationary frame or base rotatably supporting at least four sets of pivotal blades intended to be driven by impinging wind currents. Each set of blades operates in unison for opening and closing air passageways between adjacent ones of the blades as the sets of blades rotate about a common vertical axis. A wind direction sensor is provided which moves into the direction of the wind, and electro-mechanical or mechanical interface networks operably couple the wind direction sensor to the respective sets of blades whereby the blades are responsive to wind direction so as to be properly feathered to propel the sets of blades. By employment of the interface network, those blades that are in position to actuate or rotate the windmill will receive the full force of the wind while other blades which are not in a position to accomplish the proper operation will be turned to permit passage of the wind thereby.

  8. Imaging findings in pulmonary vasculitis.

    PubMed

    Castañer, Eva; Alguersuari, Anna; Andreu, Marta; Gallardo, Xavier; Spinu, Cristina; Mata, Josep M

    2012-12-01

    Vasculitis is a destructive inflammatory process affecting blood vessels. Pulmonary vasculitis may develop secondary to other conditions or constitute a primary idiopathic disorder. Thoracic involvement is most common in primary idiopathic large-vessel vasculitides (Takayasu arteritis, giant cell arteritis, Behçet disease) and primary antineutrophil cytoplasmic autoantibody-associated small-vessel vasculitides (Wegener granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome). Primary pulmonary vasculitides are rare, and their signs and symptoms are nonspecific, overlapping with those of infections, connective tissue diseases, and malignancies. The radiologic findings in primary pulmonary vasculitis vary widely and can include vessel wall thickening, nodular or cavitary lesions, ground-glass opacities, and consolidations, among others. Diffuse alveolar hemorrhage usually results from primary small-vessel vasculitis in the lungs. To diagnose vasculitis, medical teams must recognize characteristic combinations of clinical, radiologic, laboratory, and histopathologic features. PMID:23168065

  9. Research Findings on Overactive Bladder

    PubMed Central

    Patra, Phani B.; Patra, Sayani

    2015-01-01

    Several physiopathologic conditions lead to the manifestation of overactive bladder (OAB). These conditions include ageing, diabetes mellitus, bladder outlet obstruction, spinal cord injury, stroke and brain injury, Parkinson's disease, multiple sclerosis, interstitial cystitis, stress and depression. This review has discussed research findings in human and animal studies conducted on the above conditions. Several structural and functional changes under these conditions have not only been observed in the lower urinary tract, but also in the brain and spinal cord. Significant changes were observed in the following areas: neurotransmitters, prostaglandins, nerve growth factor, Rho-kinase, interstitial cells of Cajal, and ion and transient receptor potential channels. Interestingly, alterations in these areas showed great variation in each of the conditions of the OAB, suggesting that the pathophysiology of the OAB might be different in each condition of the disease. It is anticipated that this review will be helpful for further research on new and specific drug development against OAB. PMID:26195957

  10. Hit finding: towards 'smarter' approaches.

    PubMed

    Langer, Thierry; Hoffmann, Rémy; Bryant, Sharon; Lesur, Brigitte

    2009-10-01

    Drug discovery is complex and risky, and the chances of success are low. One starting point to discover a new drug is the selective screening of a collection of high value and good quality compounds. Selection of compounds for screening is one of the challenging initial steps in the drug discovery process and is crucial for the success of the project. Optimal selection will enhance the chances of successful hit finding with regard to both number and quality of hits. Several scenarios for compound selection can be envisaged, and are primarily driven by knowledge of the target. Deciding the most appropriate scenario is important and appropriate software packages and chemoinformatics tools are available for these purposes. After screening, researchers may face challenges in selecting the best hits for further optimization. Numerous chemoinformatics tools have emerged recently to address challenges in hit analysis, prioritization and optimization. PMID:19576852

  11. Magellan: Principal Venus science findings

    NASA Technical Reports Server (NTRS)

    Saunders, R. Stephen

    1993-01-01

    This is a brief summary of the science findings of the Magellan mission, principally based on data from the radar system. Future plans for Magellan include acquisition of high resolution gravity data from a nearly circular orbit and atmospheric drag and occultation experiments. The Magellan science results represent the combined effort of more than 100 Magellan investigators and their students and colleagues. More extensive discussions can be found in the August and October, 1992 issues of the Journal of Geophysical Research, Planets. The Magellan mission's scientific objectives were to provide a global characterization of landforms and tectonic features; to distinguish and understand impact processes; to define and explain erosion, deposition, and chemical processes; and to model the interior density distribution. All but the last objective, which requires new global gravity data, have been accomplished, or we have acquired the data that are required to accomplish them.

  12. Solar thermoelectric generators

    NASA Technical Reports Server (NTRS)

    1977-01-01

    The methods, the findings and the conclusions of a study for the design of a Solar Thermoelectric Generator (STG) intended for use as a power source for a spacecraft orbiting the planet Mercury are discussed. Several state-of-the-art thermoelectric technologies in the intended application were considered. The design of various STG configurations based on the thermoelectric technology selected from among the various technologies was examined in detail and a recommended STG design was derived. The performance characteristics of the selected STG technology and associated design were studied in detail as a function of the orbital characteristics of the STG in Mercury and throughout the orbit of Mercury around the sun.

  13. Finding and Not Finding Rat Perirhinal Neuronal Responses to Novelty

    PubMed Central

    Muller, Robert U.; Brown, Malcolm W.

    2016-01-01

    ABSTRACT There is much evidence that the perirhinal cortex of both rats and monkeys is important for judging the relative familiarity of visual stimuli. In monkeys many studies have found that a proportion of perirhinal neurons respond more to novel than familiar stimuli. There are fewer studies of perirhinal neuronal responses in rats, and those studies based on exploration of objects, have raised into question the encoding of stimulus familiarity by rat perirhinal neurons. For this reason, recordings of single neuronal activity were made from the perirhinal cortex of rats so as to compare responsiveness to novel and familiar stimuli in two different behavioral situations. The first situation was based upon that used in “paired viewing” experiments that have established rat perirhinal differences in immediate early gene expression for novel and familiar visual stimuli displayed on computer monitors. The second situation was similar to that used in the spontaneous object recognition test that has been widely used to establish the involvement of rat perirhinal cortex in familiarity discrimination. In the first condition 30 (25%) of 120 perirhinal neurons were visually responsive; of these responsive neurons 19 (63%) responded significantly differently to novel and familiar stimuli. In the second condition eight (53%) of 15 perirhinal neurons changed activity significantly in the vicinity of objects (had “object fields”); however, for none (0%) of these was there a significant activity change related to the familiarity of an object, an incidence significantly lower than for the first condition. Possible reasons for the difference are discussed. It is argued that the failure to find recognition‐related neuronal responses while exploring objects is related to its detectability by the measures used, rather than the absence of all such signals in perirhinal cortex. Indeed, as shown by the results, such signals are found when a different methodology is used.

  14. Finding and Not Finding Rat Perirhinal Neuronal Responses to Novelty.

    PubMed

    von Linstow Roloff, Eva; Muller, Robert U; Brown, Malcolm W

    2016-08-01

    There is much evidence that the perirhinal cortex of both rats and monkeys is important for judging the relative familiarity of visual stimuli. In monkeys many studies have found that a proportion of perirhinal neurons respond more to novel than familiar stimuli. There are fewer studies of perirhinal neuronal responses in rats, and those studies based on exploration of objects, have raised into question the encoding of stimulus familiarity by rat perirhinal neurons. For this reason, recordings of single neuronal activity were made from the perirhinal cortex of rats so as to compare responsiveness to novel and familiar stimuli in two different behavioral situations. The first situation was based upon that used in "paired viewing" experiments that have established rat perirhinal differences in immediate early gene expression for novel and familiar visual stimuli displayed on computer monitors. The second situation was similar to that used in the spontaneous object recognition test that has been widely used to establish the involvement of rat perirhinal cortex in familiarity discrimination. In the first condition 30 (25%) of 120 perirhinal neurons were visually responsive; of these responsive neurons 19 (63%) responded significantly differently to novel and familiar stimuli. In the second condition eight (53%) of 15 perirhinal neurons changed activity significantly in the vicinity of objects (had "object fields"); however, for none (0%) of these was there a significant activity change related to the familiarity of an object, an incidence significantly lower than for the first condition. Possible reasons for the difference are discussed. It is argued that the failure to find recognition-related neuronal responses while exploring objects is related to its detectability by the measures used, rather than the absence of all such signals in perirhinal cortex. Indeed, as shown by the results, such signals are found when a different methodology is used. © 2016 The Authors

  15. Seq and You Will Find.

    PubMed

    Schonrock, Nicole; Jonkhout, Nicky; Mattick, John S

    2016-01-01

    The human genome sequence is freely available, nearly complete and is providing a foundation of research opportunities that are overturning our current understanding of human biology. The advent of next generation sequencing has revolutionized the way we can interrogate the genome and its transcriptional products and how we analyze, diagnose, monitor and even treat human disease. Personal genetic profiles are increasing dramatically in medical value as researchers accumulate more and more knowledge about the interaction between genetic and environmental factors that contribute to the onset of common disorders. As the cost of sequencing plummets, whole genome sequencing of individuals is becoming a reality and the field of personalized genomic medicine is rapidly developing. Now there is great need for accurate annotation of all functionally important sequences in the human genome and the variations within them that contribute to health and disease. The vast majority of our genome gives rise to RNA transcripts. This extraordinarily versatile molecule not only encodes protein information but also has great structural dynamics and plasticity, capacity for DNA/RNA/protein interactions and catalytic activity. It is a key regulator of biological networks with clear links to human disease and a more comprehensive understanding of its function is needed to maximise its use in medical practice. This review focuses on the complexity of our genome and the impact of sequencing technologies in understanding its many products and functions in health and disease. PMID:27216913

  16. Saving the "Lost Generation"

    ERIC Educational Resources Information Center

    Beebe, Anthony E.

    2007-01-01

    Since the beginning of the American experience, labels have been used to describe generations. Among them are the "Puritan generation," the "greatest generation," the "baby boomer generation" and the "MTV generation." Today, people are creating a new generation--the "lost generation." The lost generation represents a large and growing population…

  17. Why Do First-Generation Students Fail?

    ERIC Educational Resources Information Center

    Mehta, Sanjay S.; Newbold, John J.; O'Rourke, Matthew A.

    2011-01-01

    Previous studies have determined factors contributing to first-generation student success. This study finds that first-generation students are less involved, have less social and financial support, and do not show a preference for active coping strategies. First-generation students report less social and academic satisfaction as well as lower…

  18. Knowledge translation of research findings

    PubMed Central

    2012-01-01

    Background One of the most consistent findings from clinical and health services research is the failure to translate research into practice and policy. As a result of these evidence-practice and policy gaps, patients fail to benefit optimally from advances in healthcare and are exposed to unnecessary risks of iatrogenic harms, and healthcare systems are exposed to unnecessary expenditure resulting in significant opportunity costs. Over the last decade, there has been increasing international policy and research attention on how to reduce the evidence-practice and policy gap. In this paper, we summarise the current concepts and evidence to guide knowledge translation activities, defined as T2 research (the translation of new clinical knowledge into improved health). We structure the article around five key questions: what should be transferred; to whom should research knowledge be transferred; by whom should research knowledge be transferred; how should research knowledge be transferred; and, with what effect should research knowledge be transferred? Discussion We suggest that the basic unit of knowledge translation should usually be up-to-date systematic reviews or other syntheses of research findings. Knowledge translators need to identify the key messages for different target audiences and to fashion these in language and knowledge translation products that are easily assimilated by different audiences. The relative importance of knowledge translation to different target audiences will vary by the type of research and appropriate endpoints of knowledge translation may vary across different stakeholder groups. There are a large number of planned knowledge translation models, derived from different disciplinary, contextual (i.e., setting), and target audience viewpoints. Most of these suggest that planned knowledge translation for healthcare professionals and consumers is more likely to be successful if the choice of knowledge translation strategy is informed by

  19. Somatosensory findings in postherpetic neuralgia.

    PubMed Central

    Nurmikko, T; Bowsher, D

    1990-01-01

    Somatic sensory perception thresholds (warm, cold, hot pain, touch, pinprick, vibration, two-point discrimination), allodynia and skin temperature were assessed in the affected area of 42 patients with unilateral postherpetic neuralgia (PHN) and 20 patients who had had unilateral shingles not followed by PHN (NoPHN), and in the mirror-image area on the other side. There was no difference between the two groups for age or length of time after the acute herpes zoster infection. The PHN group showed significant changes in all sensory threshold measurements when the affected area was compared with the mirror-image area on the unaffected side, while the NoPHN group exhibited no threshold changes. Mechanical allodynia was present in 87% of the PHN group; half of the 12 patients with ophthalmic PHN showed extension of allodynia to the maxillary distribution. No differences in skin temperature were recorded between affected and unaffected regions in either group. Our findings show a deficit of sensory functions mediated by both large and small primary afferent fibres and also suggest major central involvement in the pathophysiology of the condition. If PHN does not occur following acute herpes zoster, recovery of neural functions appears to be good. PMID:2313300

  20. Cancer clusters: findings vs feelings.

    PubMed

    Robinson, David

    2002-11-01

    The issue of cancer clusters, which has been in the spotlight recently, is plagued by a wide disparity between public perceptions and scientific findings. Movies like Erin Brockovich have led the public to think that industrial pollution in the environment is causing local "cancer clusters" where cancer cases are more prevalent due to cancer-causing chemicals. There are many scientifically documented instances in which chemical exposure has caused cancer in humans, but the evidence for purely environmental exposures causing cancer is sparse. The clusters that scientists have been able to attribute successfully to a particular cause have been occupational (such as workers in a factory developing a particular type of cancer from daily exposure to a specific chemical), linked to a particular medicine, or linked to behaviors such as smoking or sunbathing. There is some indication that chemicals dissolved in drinking water may elevate the risk of gastrointestinal and bladder/urinary tract cancers and that living next to a smelter or other "point source" of air pollution may elevate risk of lung cancer. The many efforts that have been made to demonstrate links between other types of cancer and environmental contamination have not conclusively identified such links. Several challenges bedevil any cancer cluster investigation and can result in ambiguous or misleading conclusions. This report discusses the potential cancer clusters in Toms River, New Jersey and Long Island, New York, because they contain many elements typical of cancer cluster investigations and have received considerable media attention. PMID:12817212

  1. Neuroimaging findings in primary insomnia.

    PubMed

    O'Byrne, J N; Berman Rosa, M; Gouin, J-P; Dang-Vu, T T

    2014-10-01

    State-of-the-art neuroimaging techniques have accelerated progress in the study and understanding of sleep in humans. Neuroimaging studies in primary insomnia remain relatively few, considering the important prevalence of this disorder in the general population. This review examines the contribution of functional and structural neuroimaging to our current understanding of primary insomnia. Functional studies during sleep provided support for the hyperarousal theory of insomnia. Functional neuroimaging also revealed abnormalities in cognitive and emotional processing in primary insomnia. Results from structural studies suggest neuroanatomical alterations in primary insomnia, mostly in the hippocampus, anterior cingulate cortex and orbitofrontal cortex. However, these results are not well replicated across studies. A few magnetic resonance spectroscopy studies revealed abnormalities in neurotransmitter concentrations and bioenergetics in primary insomnia. The inconsistencies among neuroimaging findings on insomnia are likely due to clinical heterogeneity, differences in imaging and overall diversity of techniques and designs employed. Larger samples, replication, as well as innovative methodologies are necessary for the progression of this perplexing, yet promising area of research. PMID:25129873

  2. Neuroimaging findings in primary insomnia.

    PubMed

    O'Byrne, J N; Berman Rosa, M; Gouin, J-P; Dang-Vu, T T

    2014-10-01

    State-of-the-art neuroimaging techniques have accelerated progress in the study and understanding of sleep in humans. Neuroimaging studies in primary insomnia remain relatively few, considering the important prevalence of this disorder in the general population. This review examines the contribution of functional and structural neuroimaging to our current understanding of primary insomnia. Functional studies during sleep provided support for the hyperarousal theory of insomnia. Functional neuroimaging also revealed abnormalities in cognitive and emotional processing in primary insomnia. Results from structural studies suggest neuroanatomical alterations in primary insomnia, mostly in the hippocampus, anterior cingulate cortex and orbitofrontal cortex. However, these results are not well replicated across studies. A few magnetic resonance spectroscopy studies revealed abnormalities in neurotransmitter concentrations and bioenergetics in primary insomnia. The inconsistencies among neuroimaging findings on insomnia are likely due to clinical heterogeneity, differences in imaging and overall diversity of techniques and designs employed. Larger samples, replication, as well as innovative methodologies are necessary for the progression of this perplexing, yet promising area of research.

  3. [Histologic findings in kidney tumors].

    PubMed

    Hora, M; Ouda, Z; Schejbalová, E; Chudácek, Z; Mukensnabl, P

    1997-01-01

    The authors present a group of 304 adult patients (with the exception of one child with a Wilms tumour) from 1988-95 with the diagnosis of a primary renal tumour treated by surgery and subsequently subjected to histological examination. The tumours were in 83.9% clear renal cell tumours (Grawitz carcinoma), 4.3% were papillary carcinomas, 3.3% renal cortical adenomas, 3.9% oncocytomas and 2.0% non-differentiated carcinomas, 0.7% angiomyolipomas, 0.7% chromophobe cell renal carcinomas, 0.7% secondaries (carcinoma of the breast and testis), 0.7% multilocular cysts, one case each (0.3%) Wilms tumour, malignant lymphoma, necrotic histologically not classifiable tumour. The authors give a more detailed account of multilocular cystic RCC (which accounts for 5.9% Grawitz tumours), papillary tumours, chromophobe cell renal carcinoma, oncoytoma and angiomyolipoma. The authors correlate briefly the histological findings with preoperative graphic examinations. They are very sceptical as regards assessment of the histological type of tumour from preoperative graphic examination (with the exception of angiomyolipoma). Finally the authors suggest classification of renal expansions from the urologists aspect-in the first place from preoperative graphic examinations for non-neoplastic lesions (in particular cysts and hypertrophy of the columna Bertini), parenchymatous tumours and tumours of the renal pelvis and secondly (mainly in parenchymatous tumours) histological classification is taken into account.

  4. Pollution! Find a STEM solution!

    NASA Astrophysics Data System (ADS)

    Takač, Danijela; Moćan, Marina

    2016-04-01

    Primary and secondary school Pantovčak is an innovative school in downtown Zagreb, Croatia. The school is involved in many projects concerning STEM education. Pollution! Find a STEM solution! is a two year long cross-curricular project that grew out of identified need to develop STEM and ICT skills more. Pisa results make evident that students' knowledge is poor and motivation for math and similar subjects is low. Implying priorities of European Commission, like e-learning, raises motivation and also develops basic skills and improves knowledge in science, math, physic, ICT. Main objectives are to increase students' interest in STEM education and careers and introduce them to all available new trends in technology, engineering and science in their region by visiting clean technology industries and strengthening links with them, to introduce some future digital jobs and prepare students for rapid technological changes by integrating ICT into classroom practice more, to highlight the importance of global environmental issues and improve the knowledge in the areas of sustainable development and renewable energy, to develop collaborative partnership between schools and the wider community in formal, non-formal and informal learning, to support multilingualism by publishing Open Educational Resources in 8 different languages and to strengthen the professional profile of the teaching profession. The project brings together 231 teachers and 2729 students from five different European countries in learning to think globally and work on activities that contribute to the community's well-being. There are altogether 33 activities, divided in 4 categories. STEM activities are focused on students building the devices for measuring air, light and noise pollution in their school and homes. They use the scientific method to analyze the data and compare the results with their peers to find a solution. Eskills, digital literacy and digital jobs are focused on introducing career

  5. Skin Findings in Williams Syndrome

    PubMed Central

    Kozel, Beth A.; Bayliss, Susan J.; Berk, David R.; Waxler, Jessica L; Knutsen, Russell H.; Danback, Joshua R.; Pober, Barbara R.

    2014-01-01

    Previous examination in a small number of individuals with Williams syndrome (also referred to as Williams-Beuren syndrome) has shown subtly softer skin and reduced deposition of elastin, an elastic matrix protein important in tissue recoil. No quantitative information about skin elasticity in individuals with Williams syndrome is available; nor has there been a complete report of dermatologic findings in this population. To fill this knowledge gap, 94 patients with Williams syndrome aged 7-50 years were recruited as part of the Skin and Vascular Elasticity (WS-SAVE) study. They underwent either a clinical dermatologic assessment by trained dermatologists (2010 WSA family meeting) or measurement of biomechanical properties of the skin with the DermaLab™ suction cup (2012 WSA family meeting). Clinical assessment confirmed that soft skin is common in this population (83%), as is premature graying of the hair (80% of those 20 years or older), while wrinkles (92%) and abnormal scarring (33%) were detected in larger than expected proportions. Biomechanical studies detected statistically significant differences in dP (the pressure required to lift the skin), dT (the time required to raise the skin through a prescribed gradient), VE (viscoelasticity) and E (Young’s modulus) relative to matched controls. The RT (retraction time) also trended longer but was not significant. The biomechanical differences noted in these patients did not correlate with the presence of vascular defects also attributable to elastin insufficiency (vascular stiffness, hypertension, and arterial stenosis) suggesting the presence of tissue specific modifiers that modulate the impact of elastin insufficiency in each tissue. PMID:24920525

  6. Leveraging Rigorous Local Evaluations to Understand Contradictory Findings

    ERIC Educational Resources Information Center

    Boulay, Beth; Martin, Carlos; Zief, Susan; Granger, Robert

    2013-01-01

    Contradictory findings from "well-implemented" rigorous evaluations invite researchers to identify the differences that might explain the contradictions, helping to generate testable hypotheses for new research. This panel will examine efforts to ensure that the large number of local evaluations being conducted as part of four…

  7. Empowerment: Finding Voices and Strategies To Combat Globalization.

    ERIC Educational Resources Information Center

    Te Momo, Fiona; Prihantinah, Tri Lisiani; Marinova, Dora; Stocker, Laura; Muchira, Lydiah Mumbi

    2002-01-01

    Three practice-based articles highlight common experiences and challenges in dealing with the impact of globalization: "Maori Volunteers: Finding a Voice for the Voiceless" (Te Momo); "Empowering Women through Income-generating Projects: Evidence from Indonesia" (Prihantinah, Marinova, Stocker); and "Empowering Kenyan Youth through African…

  8. 29 CFR 99.510 - Audit findings.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 1 2014-07-01 2013-07-01 true Audit findings. 99.510 Section 99.510 Labor Office of the... findings. (a) Audit findings reported. The auditor shall report the following as audit findings in a schedule of findings and questioned costs: (1) Reportable conditions in internal control over...

  9. 29 CFR 99.510 - Audit findings.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 1 2013-07-01 2013-07-01 false Audit findings. 99.510 Section 99.510 Labor Office of the... findings. (a) Audit findings reported. The auditor shall report the following as audit findings in a schedule of findings and questioned costs: (1) Reportable conditions in internal control over...

  10. 29 CFR 99.510 - Audit findings.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 1 2012-07-01 2012-07-01 false Audit findings. 99.510 Section 99.510 Labor Office of the... findings. (a) Audit findings reported. The auditor shall report the following as audit findings in a schedule of findings and questioned costs: (1) Reportable conditions in internal control over...

  11. Genetics and intelligence differences: five special findings

    PubMed Central

    Plomin, R; Deary, I J

    2015-01-01

    Intelligence is a core construct in differential psychology and behavioural genetics, and should be so in cognitive neuroscience. It is one of the best predictors of important life outcomes such as education, occupation, mental and physical health and illness, and mortality. Intelligence is one of the most heritable behavioural traits. Here, we highlight five genetic findings that are special to intelligence differences and that have important implications for its genetic architecture and for gene-hunting expeditions. (i) The heritability of intelligence increases from about 20% in infancy to perhaps 80% in later adulthood. (ii) Intelligence captures genetic effects on diverse cognitive and learning abilities, which correlate phenotypically about 0.30 on average but correlate genetically about 0.60 or higher. (iii) Assortative mating is greater for intelligence (spouse correlations ~0.40) than for other behavioural traits such as personality and psychopathology (~0.10) or physical traits such as height and weight (~0.20). Assortative mating pumps additive genetic variance into the population every generation, contributing to the high narrow heritability (additive genetic variance) of intelligence. (iv) Unlike psychiatric disorders, intelligence is normally distributed with a positive end of exceptional performance that is a model for ‘positive genetics'. (v) Intelligence is associated with education and social class and broadens the causal perspectives on how these three inter-correlated variables contribute to social mobility, and health, illness and mortality differences. These five findings arose primarily from twin studies. They are being confirmed by the first new quantitative genetic technique in a century—Genome-wide Complex Trait Analysis (GCTA)—which estimates genetic influence using genome-wide genotypes in large samples of unrelated individuals. Comparing GCTA results to the results of twin studies reveals important insights into the genetic

  12. Genetics and intelligence differences: five special findings.

    PubMed

    Plomin, R; Deary, I J

    2015-02-01

    Intelligence is a core construct in differential psychology and behavioural genetics, and should be so in cognitive neuroscience. It is one of the best predictors of important life outcomes such as education, occupation, mental and physical health and illness, and mortality. Intelligence is one of the most heritable behavioural traits. Here, we highlight five genetic findings that are special to intelligence differences and that have important implications for its genetic architecture and for gene-hunting expeditions. (i) The heritability of intelligence increases from about 20% in infancy to perhaps 80% in later adulthood. (ii) Intelligence captures genetic effects on diverse cognitive and learning abilities, which correlate phenotypically about 0.30 on average but correlate genetically about 0.60 or higher. (iii) Assortative mating is greater for intelligence (spouse correlations ~0.40) than for other behavioural traits such as personality and psychopathology (~0.10) or physical traits such as height and weight (~0.20). Assortative mating pumps additive genetic variance into the population every generation, contributing to the high narrow heritability (additive genetic variance) of intelligence. (iv) Unlike psychiatric disorders, intelligence is normally distributed with a positive end of exceptional performance that is a model for 'positive genetics'. (v) Intelligence is associated with education and social class and broadens the causal perspectives on how these three inter-correlated variables contribute to social mobility, and health, illness and mortality differences. These five findings arose primarily from twin studies. They are being confirmed by the first new quantitative genetic technique in a century-Genome-wide Complex Trait Analysis (GCTA)-which estimates genetic influence using genome-wide genotypes in large samples of unrelated individuals. Comparing GCTA results to the results of twin studies reveals important insights into the genetic architecture

  13. A Generation Immersed in Media

    ERIC Educational Resources Information Center

    Azzam, Amy M.

    2006-01-01

    This article briefly reports the findings of "Generation M: Media in the Lives of 8-18 Year-Olds," a study conducted by the Kaiser Family Foundation and Stanford University researchers. The report studied media use a nationally representative sample of more than 2,000 3rd through 12th graders in the United States. The study found that although the…

  14. Researchers Find a Mechanism for Schizophrenia

    MedlinePlus

    ... exit disclaimer . Subscribe Researchers Find a Mechanism for Schizophrenia Scientists uncovered a mechanism behind genetic variations previously linked to schizophrenia. The findings may lead to new clinical approaches. ...

  15. Finding forced trends in oceanic oxygen

    NASA Astrophysics Data System (ADS)

    Long, Matthew C.; Deutsch, Curtis; Ito, Taka

    2016-02-01

    Anthropogenically forced trends in oceanic dissolved oxygen are evaluated in Earth system models in the context of natural variability. A large ensemble of a single Earth system model is used to clearly identify the forced component of change in interior oxygen distributions and to evaluate the magnitude of this signal relative to noise generated by internal climate variability. The time of emergence of forced trends is quantified on the basis of anomalies in oxygen concentrations and trends. We find that the forced signal should already be evident in the southern Indian Ocean and parts of the eastern tropical Pacific and Atlantic basins; widespread detection of forced deoxygenation is possible by 2030-2040. In addition to considering spatially discrete metrics of detection, we evaluate the similarity of the spatial structures associated with natural variability and the forced trend. Outside of the subtropics, these patterns are not wholly distinct on the isopycnal surfaces considered, and therefore, this approach does not provide significantly advanced detection. Our results clearly demonstrate the strong impact of natural climate variability on interior oxygen distributions, providing an important context for interpreting observations.

  16. 20 CFR 617.44 - Findings required.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Findings required. 617.44 Section 617.44... FOR WORKERS UNDER THE TRADE ACT OF 1974 Relocation Allowances § 617.44 Findings required. (a) Findings... findings shall be made by the liable State: (1) The individual meets the eligibility requirements for...

  17. 20 CFR 617.44 - Findings required.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 3 2013-04-01 2013-04-01 false Findings required. 617.44 Section 617.44... FOR WORKERS UNDER THE TRADE ACT OF 1974 Relocation Allowances § 617.44 Findings required. (a) Findings... findings shall be made by the liable State: (1) The individual meets the eligibility requirements for...

  18. 20 CFR 617.44 - Findings required.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Findings required. 617.44 Section 617.44... FOR WORKERS UNDER THE TRADE ACT OF 1974 Relocation Allowances § 617.44 Findings required. (a) Findings... findings shall be made by the liable State: (1) The individual meets the eligibility requirements for...

  19. 20 CFR 617.44 - Findings required.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 3 2012-04-01 2012-04-01 false Findings required. 617.44 Section 617.44... FOR WORKERS UNDER THE TRADE ACT OF 1974 Relocation Allowances § 617.44 Findings required. (a) Findings... findings shall be made by the liable State: (1) The individual meets the eligibility requirements for...

  20. 29 CFR 551.7 - Finding.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 3 2012-07-01 2012-07-01 false Finding. 551.7 Section 551.7 Labor Regulations Relating to... HELPERS; WAGE PAYMENT PLANS § 551.7 Finding. (a) A finding by the Administrator under paragraph (b) of... petitioners as provided in § 551.6(b). The finding shall include such terms and conditions and...

  1. 29 CFR 551.7 - Finding.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 3 2013-07-01 2013-07-01 false Finding. 551.7 Section 551.7 Labor Regulations Relating to... HELPERS; WAGE PAYMENT PLANS § 551.7 Finding. (a) A finding by the Administrator under paragraph (b) of... petitioners as provided in § 551.6(b). The finding shall include such terms and conditions and...

  2. 2 CFR 200.5 - Audit finding.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Audit finding. 200.5 Section 200.5 Grants... REQUIREMENTS FOR FEDERAL AWARDS Acronyms and Definitions Acronyms § 200.5 Audit finding. Audit finding means deficiencies which the auditor is required by § 200.516 Audit findings, paragraph (a) to report in the...

  3. 29 CFR 551.7 - Finding.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Finding. 551.7 Section 551.7 Labor Regulations Relating to... HELPERS; WAGE PAYMENT PLANS § 551.7 Finding. (a) A finding by the Administrator under paragraph (b) of... petitioners as provided in § 551.6(b). The finding shall include such terms and conditions and...

  4. 38 CFR 41.510 - Audit findings.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2012-07-01 2012-07-01 false Audit findings. 41.510... OF STATES, LOCAL GOVERNMENTS, AND NON-PROFIT ORGANIZATIONS Auditors § 41.510 Audit findings. (a) Audit findings reported. The auditor shall report the following as audit findings in a schedule...

  5. 48 CFR 9903.201-6 - Findings.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 7 2013-10-01 2012-10-01 true Findings. 9903.201-6... STANDARDS CONTRACT COVERAGE CAS Program Requirements 9903.201-6 Findings. (a) Required change—(1) Finding... forth in 9903.201-4(c), the Contracting Officer shall make a finding that the practice change...

  6. 38 CFR 41.510 - Audit findings.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2014-07-01 2014-07-01 false Audit findings. 41.510... OF STATES, LOCAL GOVERNMENTS, AND NON-PROFIT ORGANIZATIONS Auditors § 41.510 Audit findings. (a) Audit findings reported. The auditor shall report the following as audit findings in a schedule...

  7. 29 CFR 551.7 - Finding.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 3 2014-07-01 2014-07-01 false Finding. 551.7 Section 551.7 Labor Regulations Relating to... HELPERS; WAGE PAYMENT PLANS § 551.7 Finding. (a) A finding by the Administrator under paragraph (b) of... petitioners as provided in § 551.6(b). The finding shall include such terms and conditions and...

  8. 20 CFR 617.33 - Findings required.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 3 2012-04-01 2012-04-01 false Findings required. 617.33 Section 617.33... FOR WORKERS UNDER THE TRADE ACT OF 1974 Job Search Allowances § 617.33 Findings required. (a) Findings... findings shall be made by the liable State: (1) The individual meets the eligibility requirements for a...

  9. 20 CFR 617.33 - Findings required.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 3 2013-04-01 2013-04-01 false Findings required. 617.33 Section 617.33... FOR WORKERS UNDER THE TRADE ACT OF 1974 Job Search Allowances § 617.33 Findings required. (a) Findings... findings shall be made by the liable State: (1) The individual meets the eligibility requirements for a...

  10. 7 CFR 1794.43 - Agency finding.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false Agency finding. 1794.43 Section 1794.43 Agriculture... finding. If RUS finds, based on an EA that the proposed action will not have a significant effect on the... have a notice published which informs the public of the RUS finding and the availability of the EA...

  11. 48 CFR 9903.201-6 - Findings.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 7 2012-10-01 2012-10-01 false Findings. 9903.201-6... STANDARDS CONTRACT COVERAGE CAS Program Requirements 9903.201-6 Findings. (a) Required change—(1) Finding... forth in 9903.201-4(c), the Contracting Officer shall make a finding that the practice change...

  12. 7 CFR 1794.43 - Agency finding.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 12 2012-01-01 2012-01-01 false Agency finding. 1794.43 Section 1794.43 Agriculture... finding. If RUS finds, based on an EA that the proposed action will not have a significant effect on the... have a notice published which informs the public of the RUS finding and the availability of the EA...

  13. 20 CFR 617.44 - Findings required.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 3 2014-04-01 2014-04-01 false Findings required. 617.44 Section 617.44... FOR WORKERS UNDER THE TRADE ACT OF 1974 Relocation Allowances § 617.44 Findings required. (a) Findings... findings shall be made by the liable State: (1) The individual meets the eligibility requirements for...

  14. 48 CFR 9903.201-6 - Findings.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 7 2014-10-01 2014-10-01 false Findings. 9903.201-6... STANDARDS CONTRACT COVERAGE CAS Program Requirements 9903.201-6 Findings. (a) Required change—(1) Finding... forth in 9903.201-4(c), the Contracting Officer shall make a finding that the practice change...

  15. 29 CFR 551.7 - Finding.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 3 2011-07-01 2011-07-01 false Finding. 551.7 Section 551.7 Labor Regulations Relating to... HELPERS; WAGE PAYMENT PLANS § 551.7 Finding. (a) A finding by the Administrator under paragraph (b) of... petitioners as provided in § 551.6(b). The finding shall include such terms and conditions and...

  16. 38 CFR 41.510 - Audit findings.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2013-07-01 2013-07-01 false Audit findings. 41.510... OF STATES, LOCAL GOVERNMENTS, AND NON-PROFIT ORGANIZATIONS Auditors § 41.510 Audit findings. (a) Audit findings reported. The auditor shall report the following as audit findings in a schedule...

  17. 29 CFR 99.510 - Audit findings.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Audit findings. 99.510 Section 99.510 Labor Office of the Secretary of Labor AUDITS OF STATES, LOCAL GOVERNMENTS, AND NON-PROFIT ORGANIZATIONS Auditors § 99.510 Audit findings. (a) Audit findings reported. The auditor shall report the following as audit findings in...

  18. Net Generation or Digital Natives: Is There a Distinct New Generation Entering University?

    ERIC Educational Resources Information Center

    Jones, Chris; Ramanau, Ruslan; Cross, Simon; Healing, Graham

    2010-01-01

    This article reports key findings from the first phase of a research project investigating Net generation age students as they encounter e-learning at five universities in England. We take a critical view of the idea of a distinct generation which has been described using various terms including Net generation and Digital Natives and explore age…

  19. Generating random density matrices

    NASA Astrophysics Data System (ADS)

    Życzkowski, Karol; Penson, Karol A.; Nechita, Ion; Collins, Benoît

    2011-06-01

    We study various methods to generate ensembles of random density matrices of a fixed size N, obtained by partial trace of pure states on composite systems. Structured ensembles of random pure states, invariant with respect to local unitary transformations are introduced. To analyze statistical properties of quantum entanglement in bi-partite systems we analyze the distribution of Schmidt coefficients of random pure states. Such a distribution is derived in the case of a superposition of k random maximally entangled states. For another ensemble, obtained by performing selective measurements in a maximally entangled basis on a multi-partite system, we show that this distribution is given by the Fuss-Catalan law and find the average entanglement entropy. A more general class of structured ensembles proposed, containing also the case of Bures, forms an extension of the standard ensemble of structureless random pure states, described asymptotically, as N → ∞, by the Marchenko-Pastur distribution.

  20. Examining Alternatives to Wavelet Denoising for Astronomical Source Finding

    NASA Astrophysics Data System (ADS)

    Jurek, R.; Brown, S.

    2012-08-01

    The Square Kilometre Array and its pathfinders ASKAP and MeerKAT will produce prodigious amounts of data that necessitate automated source finding. The performance of automated source finders can be improved by pre-processing a dataset. In preparation for the WALLABY and DINGO surveys, we have used a test HI datacube constructed from actual Westerbork Telescope noise and WHISP HI galaxies to test the real world improvement of linear smoothing, the Duchamp source finder's wavelet denoising, iterative median smoothing and mathematical morphology subtraction, on intensity threshold source finding of spectral line datasets. To compare these pre-processing methods we have generated completeness-reliability performance curves for each method and a range of input parameters. We find that iterative median smoothing produces the best source finding results for ASKAP HI spectral line observations, but wavelet denoising is a safer pre-processing technique. In this paper we also present our implementations of iterative median smoothing and mathematical morphology subtraction.

  1. Generational Dynamics and Librarianship: Managing Generation X.

    ERIC Educational Resources Information Center

    Cooper, Julie F.; Cooper, Eric A.

    1998-01-01

    Explores the abilities of Generation X (individuals born 1961 to 1981) librarians to respond to the evolving needs of society. Highlights include age demographics, generational attributes, technology, and the seniority system. (PEN)

  2. Electrical power generating system. [for windpowered generation

    NASA Technical Reports Server (NTRS)

    Nola, F. J. (Inventor)

    1981-01-01

    An alternating current power generation system adopted to inject power in an already powered power line is discussed. The power generating system solves to adjustably coup an induction motor, as a generator, to an ac power line wherein the motor and power line are connected through a triac. The triac is regulated to normally turn on at a relatively late point in each half cycle of its operation, whereby at less than operating speed, and thus when the induction motor functions as a motor rather than as a generator, power consumption from the line is substantially reduced. The principal application will be for windmill powered generation.

  3. Where will we find tomorrow's leaders?

    PubMed

    Hill, Linda A

    2008-01-01

    Unless we challenge long-held assumptions about how business leaders are supposed to act and where they're supposed to come from, many people who could become effective global leaders will remain invisible, warns Harvard Business School professor Hill. Instead of assuming that leaders must exhibit take-charge behavior, broaden the definition of leadership to include creating a context in which other people are willing and able to guide the organization. And instead of looking for the next generation of global leaders in huge Western corporations and elite business schools, expand the search to developing countries. In this conversation with HBR senior editor Paul Hemp, Hill describes the changing nature of leadership and what we can learn from parts of the world where people have not, until recently, had opportunities to become globally savvy executives. In South Africa, for instance, the African National Congress has provided rigorous leadership preparation for many black executives. Hill has also observed two approaches--in developed and developing economies alike--that she believes will be necessary in an increasingly complex business environment. The first, leading from behind, involves letting people hand off the reins to one another, depending on their strengths, as situations change. The second, leadership as collective genius, calls for both unleashing and harnessing individuals' collective talents, particularly to spur innovation. Through her descriptions of these approaches in such companies as Sekunjalo Investments, HCL Technologies, and IBM, Hill highlights the challenges of finding and preparing people who can lead by stepping back and letting others come forward to make their own judgments and take risks.

  4. Development of automated detection of radiology reports citing adrenal findings

    NASA Astrophysics Data System (ADS)

    Zopf, Jason; Langer, Jessica; Boonn, William; Kim, Woojin; Zafar, Hanna

    2011-03-01

    Indeterminate incidental findings pose a challenge to both the radiologist and the ordering physician as their imaging appearance is potentially harmful but their clinical significance and optimal management is unknown. We seek to determine if it is possible to automate detection of adrenal nodules, an indeterminate incidental finding, on imaging examinations at our institution. Using PRESTO (Pathology-Radiology Enterprise Search tool), a newly developed search engine at our institution that mines dictated radiology reports, we searched for phrases used by attendings to describe incidental adrenal findings. Using these phrases as a guide, we designed a query that can be used with the PRESTO index. The results were refined using a modified version of NegEx to eliminate query terms that have been negated within the report text. In order to validate these findings we used an online random date generator to select two random weeks. We queried our RIS database for all reports created on those dates and manually reviewed each report to check for adrenal incidental findings. This survey produced a ground- truth dataset of reports citing adrenal incidental findings against which to compare query performance. We further reviewed the false positives and negatives identified by our validation study, in an attempt to improve the performance query. This algorithm is an important step towards automating the detection of incidental adrenal nodules on cross sectional imaging at our institution. Subsequently, this query can be combined with electronic medical record data searches to determine the clinical significance of these findings through resultant follow-up.

  5. Talkin' 'bout My Generation

    ERIC Educational Resources Information Center

    Rickes, Persis C.

    2010-01-01

    The monikers are many: (1) "Generation Y"; (2) "Echo Boomers"; (3) "GenMe"; (4) the "Net Generation"; (5) "RenGen"; and (6) "Generation Next". One name that appears to be gaining currency is "Millennials," perhaps as a way to better differentiate the current generation from its predecessor, Generation X. Millennials are those individuals born…

  6. 16 CFR 1633.8 - Findings.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... (OPEN FLAME) OF MATTRESS SETS The Standard § 1633.8 Findings. (a) General. In order to issue a..., the Commission finds that an open flame standard for mattresses with the testing requirements...

  7. 16 CFR 1633.8 - Findings.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... (OPEN FLAME) OF MATTRESS SETS The Standard § 1633.8 Findings. (a) General. In order to issue a..., the Commission finds that an open flame standard for mattresses with the testing requirements...

  8. 16 CFR 1633.8 - Findings.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... (OPEN FLAME) OF MATTRESS SETS The Standard § 1633.8 Findings. (a) General. In order to issue a..., the Commission finds that an open flame standard for mattresses with the testing requirements...

  9. 16 CFR 1633.8 - Findings.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... (OPEN FLAME) OF MATTRESS SETS The Standard § 1633.8 Findings. (a) General. In order to issue a..., the Commission finds that an open flame standard for mattresses with the testing requirements...

  10. 16 CFR 1633.8 - Findings.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... (OPEN FLAME) OF MATTRESS SETS The Standard § 1633.8 Findings. (a) General. In order to issue a..., the Commission finds that an open flame standard for mattresses with the testing requirements...

  11. CDC Study Finds Fecal Contamination in Pools

    MedlinePlus

    ... Communication (404) 639-3286 CDC study finds fecal contamination in pools A study of public pools done ... The E. coli is a marker for fecal contamination. Finding a high percentage of E. coli-positive ...

  12. 10 CFR 1022.14 - Findings.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... findings to the State in accordance with 10 CFR part 1005—Intergovernmental Review of Department of Energy... ENERGY (GENERAL PROVISIONS) COMPLIANCE WITH FLOODPLAIN AND WETLAND ENVIRONMENTAL REVIEW REQUIREMENTS Procedures for Floodplain and Wetland Reviews § 1022.14 Findings. (a) If DOE finds that no...

  13. 10 CFR 1022.14 - Findings.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... findings to the State in accordance with 10 CFR part 1005—Intergovernmental Review of Department of Energy... ENERGY (GENERAL PROVISIONS) COMPLIANCE WITH FLOODPLAIN AND WETLAND ENVIRONMENTAL REVIEW REQUIREMENTS Procedures for Floodplain and Wetland Reviews § 1022.14 Findings. (a) If DOE finds that no...

  14. 10 CFR 1022.14 - Findings.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... findings to the State in accordance with 10 CFR part 1005—Intergovernmental Review of Department of Energy... ENERGY (GENERAL PROVISIONS) COMPLIANCE WITH FLOODPLAIN AND WETLAND ENVIRONMENTAL REVIEW REQUIREMENTS Procedures for Floodplain and Wetland Reviews § 1022.14 Findings. (a) If DOE finds that no...

  15. 10 CFR 1022.14 - Findings.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... findings to the State in accordance with 10 CFR part 1005—Intergovernmental Review of Department of Energy... ENERGY (GENERAL PROVISIONS) COMPLIANCE WITH FLOODPLAIN AND WETLAND ENVIRONMENTAL REVIEW REQUIREMENTS Procedures for Floodplain and Wetland Reviews § 1022.14 Findings. (a) If DOE finds that no...

  16. 10 CFR 1022.14 - Findings.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... findings to the State in accordance with 10 CFR part 1005—Intergovernmental Review of Department of Energy... ENERGY (GENERAL PROVISIONS) COMPLIANCE WITH FLOODPLAIN AND WETLAND ENVIRONMENTAL REVIEW REQUIREMENTS Procedures for Floodplain and Wetland Reviews § 1022.14 Findings. (a) If DOE finds that no...

  17. 7 CFR 1735.50 - Administrative findings.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... to support these findings are included in 7 CFR part 1737. ... 7 Agriculture 11 2012-01-01 2012-01-01 false Administrative findings. 1735.50 Section 1735.50... For Loan Approval § 1735.50 Administrative findings. The RE Act requires that the Administrator...

  18. 7 CFR 1735.50 - Administrative findings.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... to support these findings are included in 7 CFR part 1737. ... 7 Agriculture 11 2014-01-01 2014-01-01 false Administrative findings. 1735.50 Section 1735.50... For Loan Approval § 1735.50 Administrative findings. The RE Act requires that the Administrator...

  19. 16 CFR 1213.7 - Findings.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Findings. 1213.7 Section 1213.7 Commercial... ENTRAPMENT HAZARDS IN BUNK BEDS § 1213.7 Findings. The Consumer Product Safety Act requires that the Commission, in order to issue a standard, make the following findings and include them in the rule. 15...

  20. 49 CFR 845.27 - Proposed findings.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 7 2014-10-01 2014-10-01 false Proposed findings. 845.27 Section 845.27 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL TRANSPORTATION SAFETY BOARD... Proposed findings. Any party may submit proposed findings to be drawn from the testimony and exhibits,...

  1. 16 CFR 1212.5 - Findings.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Findings. 1212.5 Section 1212.5 Commercial... MULTI-PURPOSE LIGHTERS Requirements for Child-Resistance § 1212.5 Findings. (a) Before issuing a final... and make appropriate findings for inclusion in the rule with respect to: (1) The degree and nature...

  2. 16 CFR 1212.5 - Findings.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Findings. 1212.5 Section 1212.5 Commercial... MULTI-PURPOSE LIGHTERS Requirements for Child-Resistance § 1212.5 Findings. (a) Before issuing a final... and make appropriate findings for inclusion in the rule with respect to: (1) The degree and nature...

  3. 15 CFR 971.301 - Required findings.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 3 2012-01-01 2012-01-01 false Required findings. 971.301 Section 971... Applications § 971.301 Required findings. Before the Administrator may certify an application for a commercial... imposition of reasonable restrictions; and (b) Find that the applicant— (1) Has demonstrated that,...

  4. 15 CFR 971.301 - Required findings.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 3 2014-01-01 2014-01-01 false Required findings. 971.301 Section 971... Applications § 971.301 Required findings. Before the Administrator may certify an application for a commercial... imposition of reasonable restrictions; and (b) Find that the applicant— (1) Has demonstrated that,...

  5. 22 CFR 710.10 - Findings.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 2 2012-04-01 2009-04-01 true Findings. 710.10 Section 710.10 Foreign... PROCEDURES OF POST-EMPLOYMENT RESTRICTIONS § 710.10 Findings. The examiner shall make a determination exclusively on matters of record in the proceeding and shall set forth in the written decision all findings...

  6. 22 CFR 710.10 - Findings.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 2 2014-04-01 2014-04-01 false Findings. 710.10 Section 710.10 Foreign... PROCEDURES OF POST-EMPLOYMENT RESTRICTIONS § 710.10 Findings. The examiner shall make a determination exclusively on matters of record in the proceeding and shall set forth in the written decision all findings...

  7. 7 CFR 1735.50 - Administrative findings.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... to support these findings are included in 7 CFR part 1737. ... 7 Agriculture 11 2013-01-01 2013-01-01 false Administrative findings. 1735.50 Section 1735.50... For Loan Approval § 1735.50 Administrative findings. The RE Act requires that the Administrator...

  8. 16 CFR 1212.5 - Findings.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Findings. 1212.5 Section 1212.5 Commercial... MULTI-PURPOSE LIGHTERS Requirements for Child-Resistance § 1212.5 Findings. (a) Before issuing a final... and make appropriate findings for inclusion in the rule with respect to: (1) The degree and nature...

  9. 7 CFR 29.98 - Appeal findings.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Appeal findings. 29.98 Section 29.98 Agriculture... INSPECTION Regulations Appeal § 29.98 Appeal findings. Immediately after an appeal has been heard and the... prepared by the appeal inspector. Such certificate or sample shall show the finding of the appeal...

  10. 49 CFR 845.27 - Proposed findings.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 7 2011-10-01 2011-10-01 false Proposed findings. 845.27 Section 845.27 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL TRANSPORTATION SAFETY BOARD... Proposed findings. Any party may submit proposed findings to be drawn from the testimony and exhibits,...

  11. 7 CFR 29.98 - Appeal findings.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 2 2014-01-01 2014-01-01 false Appeal findings. 29.98 Section 29.98 Agriculture... INSPECTION Regulations Appeal § 29.98 Appeal findings. Immediately after an appeal has been heard and the... prepared by the appeal inspector. Such certificate or sample shall show the finding of the appeal...

  12. 49 CFR 831.14 - Proposed findings.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 7 2012-10-01 2012-10-01 false Proposed findings. 831.14 Section 831.14... ACCIDENT/INCIDENT INVESTIGATION PROCEDURES § 831.14 Proposed findings. (a) General. Any person, government... accident or incident under investigation may submit to the Board written proposed findings to be drawn...

  13. 49 CFR 845.27 - Proposed findings.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 7 2012-10-01 2012-10-01 false Proposed findings. 845.27 Section 845.27 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL TRANSPORTATION SAFETY BOARD... Proposed findings. Any party may submit proposed findings to be drawn from the testimony and exhibits,...

  14. 16 CFR 1212.5 - Findings.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Findings. 1212.5 Section 1212.5 Commercial... MULTI-PURPOSE LIGHTERS Requirements for Child-Resistance § 1212.5 Findings. (a) Before issuing a final... and make appropriate findings for inclusion in the rule with respect to: (1) The degree and nature...

  15. 10 CFR 800.201 - Findings.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Findings. 800.201 Section 800.201 Energy DEPARTMENT OF... ASSISTANCE Loans § 800.201 Findings. A loan shall issue under this regulation only if the Secretary, having... the Secretary may deem pertinent, has made all the findings that follow: (a) That the applicant is...

  16. 7 CFR 29.98 - Appeal findings.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 2 2011-01-01 2011-01-01 false Appeal findings. 29.98 Section 29.98 Agriculture... INSPECTION Regulations Appeal § 29.98 Appeal findings. Immediately after an appeal has been heard and the... prepared by the appeal inspector. Such certificate or sample shall show the finding of the appeal...

  17. 49 CFR 831.14 - Proposed findings.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 7 2014-10-01 2014-10-01 false Proposed findings. 831.14 Section 831.14... ACCIDENT/INCIDENT INVESTIGATION PROCEDURES § 831.14 Proposed findings. (a) General. Any person, government... accident or incident under investigation may submit to the Board written proposed findings to be drawn...

  18. 16 CFR 1212.5 - Findings.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Findings. 1212.5 Section 1212.5 Commercial... MULTI-PURPOSE LIGHTERS Requirements for Child-Resistance § 1212.5 Findings. (a) Before issuing a final... and make appropriate findings for inclusion in the rule with respect to: (1) The degree and nature...

  19. 16 CFR 1213.7 - Findings.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Findings. 1213.7 Section 1213.7 Commercial... ENTRAPMENT HAZARDS IN BUNK BEDS § 1213.7 Findings. The Consumer Product Safety Act requires that the Commission, in order to issue a standard, make the following findings and include them in the rule. 15...

  20. 22 CFR 710.10 - Findings.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 2 2013-04-01 2009-04-01 true Findings. 710.10 Section 710.10 Foreign... PROCEDURES OF POST-EMPLOYMENT RESTRICTIONS § 710.10 Findings. The examiner shall make a determination exclusively on matters of record in the proceeding and shall set forth in the written decision all findings...

  1. 49 CFR 831.14 - Proposed findings.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 7 2013-10-01 2013-10-01 false Proposed findings. 831.14 Section 831.14... ACCIDENT/INCIDENT INVESTIGATION PROCEDURES § 831.14 Proposed findings. (a) General. Any person, government... accident or incident under investigation may submit to the Board written proposed findings to be drawn...

  2. 49 CFR 831.14 - Proposed findings.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 7 2011-10-01 2011-10-01 false Proposed findings. 831.14 Section 831.14... ACCIDENT/INCIDENT INVESTIGATION PROCEDURES § 831.14 Proposed findings. (a) General. Any person, government... accident or incident under investigation may submit to the Board written proposed findings to be drawn...

  3. 7 CFR 1735.50 - Administrative findings.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... to support these findings are included in 7 CFR part 1737. ... 7 Agriculture 11 2010-01-01 2010-01-01 false Administrative findings. 1735.50 Section 1735.50... For Loan Approval § 1735.50 Administrative findings. The RE Act requires that the Administrator...

  4. 7 CFR 1735.50 - Administrative findings.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... to support these findings are included in 7 CFR part 1737. ... 7 Agriculture 11 2011-01-01 2011-01-01 false Administrative findings. 1735.50 Section 1735.50... For Loan Approval § 1735.50 Administrative findings. The RE Act requires that the Administrator...

  5. 22 CFR 710.10 - Findings.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 2 2011-04-01 2009-04-01 true Findings. 710.10 Section 710.10 Foreign... PROCEDURES OF POST-EMPLOYMENT RESTRICTIONS § 710.10 Findings. The examiner shall make a determination exclusively on matters of record in the proceeding and shall set forth in the written decision all findings...

  6. 7 CFR 29.98 - Appeal findings.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 2 2013-01-01 2013-01-01 false Appeal findings. 29.98 Section 29.98 Agriculture... INSPECTION Regulations Appeal § 29.98 Appeal findings. Immediately after an appeal has been heard and the... prepared by the appeal inspector. Such certificate or sample shall show the finding of the appeal...

  7. 22 CFR 710.10 - Findings.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Findings. 710.10 Section 710.10 Foreign... PROCEDURES OF POST-EMPLOYMENT RESTRICTIONS § 710.10 Findings. The examiner shall make a determination exclusively on matters of record in the proceeding and shall set forth in the written decision all findings...

  8. 15 CFR 971.301 - Required findings.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 3 2011-01-01 2011-01-01 false Required findings. 971.301 Section 971... Applications § 971.301 Required findings. Before the Administrator may certify an application for a commercial... imposition of reasonable restrictions; and (b) Find that the applicant— (1) Has demonstrated that,...

  9. 7 CFR 29.98 - Appeal findings.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 2 2012-01-01 2012-01-01 false Appeal findings. 29.98 Section 29.98 Agriculture... INSPECTION Regulations Appeal § 29.98 Appeal findings. Immediately after an appeal has been heard and the... prepared by the appeal inspector. Such certificate or sample shall show the finding of the appeal...

  10. 15 CFR 971.301 - Required findings.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 3 2013-01-01 2013-01-01 false Required findings. 971.301 Section 971... Applications § 971.301 Required findings. Before the Administrator may certify an application for a commercial... imposition of reasonable restrictions; and (b) Find that the applicant— (1) Has demonstrated that,...

  11. 15 CFR 971.301 - Required findings.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Required findings. 971.301 Section 971... Applications § 971.301 Required findings. Before the Administrator may certify an application for a commercial... imposition of reasonable restrictions; and (b) Find that the applicant— (1) Has demonstrated that,...

  12. 5 CFR 2638.504 - Director's finding.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 3 2012-01-01 2012-01-01 false Director's finding. 2638.504 Section 2638... Individual Executive Agency Employees § 2638.504 Director's finding. (a) In general. If the Director has... initiate proceedings under this section for the purpose of making a finding as to whether there is or...

  13. 49 CFR 845.27 - Proposed findings.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 7 2010-10-01 2010-10-01 false Proposed findings. 845.27 Section 845.27 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL TRANSPORTATION SAFETY BOARD... Proposed findings. Any party may submit proposed findings to be drawn from the testimony and exhibits,...

  14. 16 CFR 1213.7 - Findings.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Findings. 1213.7 Section 1213.7 Commercial... ENTRAPMENT HAZARDS IN BUNK BEDS § 1213.7 Findings. The Consumer Product Safety Act requires that the Commission, in order to issue a standard, make the following findings and include them in the rule. 15...

  15. 16 CFR 1213.7 - Findings.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Findings. 1213.7 Section 1213.7 Commercial... ENTRAPMENT HAZARDS IN BUNK BEDS § 1213.7 Findings. The Consumer Product Safety Act requires that the Commission, in order to issue a standard, make the following findings and include them in the rule. 15...

  16. 49 CFR 845.27 - Proposed findings.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 7 2013-10-01 2013-10-01 false Proposed findings. 845.27 Section 845.27 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL TRANSPORTATION SAFETY BOARD... Proposed findings. Any party may submit proposed findings to be drawn from the testimony and exhibits,...

  17. MHD Power Generation

    ERIC Educational Resources Information Center

    Kantrowitz, Arthur; Rosa, Richard J.

    1975-01-01

    Explains the operation of the Magnetohydrodynamic (MHD) generator and advantages of the system over coal, oil or nuclear powered generators. Details the development of MHD generators in the United States and Soviet Union. (CP)

  18. The fourth generation in supergravity

    NASA Astrophysics Data System (ADS)

    Enqvist, K.; Nanopoulos, D. V.; Zwirner, F.

    1985-12-01

    We consider model-independent constraints on the fourth-generation fermion masses and the magnitude of the D-term contribution to the scalar masses. We find that the ratio of vacuum expectation values is limited to the range 1/5 <~ ν2/ν 1 <~ 4.5. We compute the mass spectrum in the class of models where the only source of soft supersymmetry breaking is the gaugino mass m1/2. The lightest charged scalar turns out to be the fourth-generation slepton, which may be ligth enough to be pair-produced at LEP. The present PETRA bound on new charged particles implies that m1/2 >~ 150 GeV. A general feature of the four-generation models is thus a heavy spectrum of sparticles. On leave from International School for Advanced Studies, Trieste, and Istituto Nazionale di Fisica Nucleare, Padua, Italy.

  19. Cosmic Shell-Seekers Find a Beauty

    NASA Astrophysics Data System (ADS)

    2005-04-01

    Two scientists have discovered a distinctive shell of hot gas around the site of a distant supernova explosion by combining 150 hours of archived data collected by NASA's Chandra X-ray Observatory. This discovery is a significant step forward in solving a decades-old puzzle as to why some stellar explosions display shells and others do not. "The likely answer is that the explosion of every massive star sends a sonic boom rumbling through interstellar space," said Samar Safi-Harb of the University of Manitoba in Winnipeg, Canada, who is a coauthor with Heather Matheson on a paper describing the research that appears in the journal Advances in Space Research. "It's just that, some of the shells are harder to find than others because of the environment where the explosion occurs." The shell marks a sonic boom, or shock wave, generated by the supernova. Gas is heated to millions of degrees by the shock wave and produces X-rays, but little visible light. By examining the properties of the shell with an X-ray telescope, astronomers can work back to deduce the age (a few thousand years), and energy of the explosion, as well as information about the state of the star a million years before it exploded. Animation of a Supernova Explosion Animation of a Supernova Explosion It is likely that the star that produced the supernova remnant and shell was about 10 times as massive as the Sun. The absence of a detectable shell around this and similar supernova remnants had led astronomers to speculate that another, weaker type of explosion had occurred there. Now this hypothesis seems unlikely. Although many supernovas leave behind bright shells, others do not. This supernova remnant, identified as G21.5-0.9 by radio astronomers 30 years ago, was considered to be one that had no shell. A diffuse cloud of X-rays around the source was detected about 5 years ago by another group of astronomers and independently by Safi-Harb and colleagues using Chandra, but it took the careful

  20. The American Reincarnation of the Superfluous Experience: Finding Meaning in Generation Y

    ERIC Educational Resources Information Center

    Duffey, Madelyn Elizabeth

    2005-01-01

    The superfluous man became a prominent literary figure in Russia during the 19th century. This article makes a comparison of the superfluous experience to the "celebutante" phenomenon, as reflected in the media. It also includes a discussion on the impact that the celebutante influence may have on the dreams, values and meaning-making experience…

  1. Toward Reducing Poverty across Generations: Early Findings from New York City's Conditional Cash Transfer Program

    ERIC Educational Resources Information Center

    Miller, Cynthia; Riccio, James

    2011-01-01

    Aimed at low-income families in six of New York City's highest-poverty communities, Family Rewards ties cash rewards to a pre-specified set of activities and outcomes thought to be critical to families' short- and long-term success in the areas of children's education, family preventive health care, and parents' employment. The purpose of this…

  2. Identification of feigned mental retardation using the new generation of malingering detection instruments: preliminary findings.

    PubMed

    Graue, Lili O; Berry, David T R; Clark, Jessica A; Sollman, Myriam J; Cardi, Michelle; Hopkins, Jaclyn; Werline, Dellynda

    2007-12-01

    A recent Supreme Court decision--Atkins v. Virginia, 536 U.S. 304 (2002)--prohibiting the execution of mentally retarded (MR) defendants may have raised the attractiveness of feigning this condition in the criminal justice system. Unfortunately, very few published studies have addressed the detection of feigned MR. The present report compared results from tests of intelligence, psychiatric feigning, and neurocognitive faking in a group of 26 mild MR participants (MR) and 25 demographically matched community volunteers asked to feign MR (CVM). Results showed that the CVM suppressed their IQ scores to approximate closely the level of MR participants. WAIS-III and psychiatric malingering measures were relatively ineffective at discriminating feigned from genuine MR. Although neurocognitive malingering tests were more accurate, their reduced specificity in MR participants was of potential concern. Revised cutting scores, set to maintain a Specificity rate of about .95 in MR clients, were identified, although they require cross-validation. Overall, these results suggest that new cutting scores will likely need to be validated to detect feigned MR using current malingering instruments.

  3. 75 FR 10834 - Energy Northwest; Columbia Generating Station; Environmental Assessment and Finding of No...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-09

    ... part 73, does not involve any physical changes to the reactor, fuel, plant structures, support... March 27, 2009 (74 FR 13926). There will be no change to radioactive effluents that affect radiation...,'' from the implementation date for one new requirement of 10 CFR part 73, ``Physical protection of...

  4. Next Generation UAV Based Spectral Systems for Environmental Monitoring: project developments, preliminary outcome and findings

    NASA Astrophysics Data System (ADS)

    Campbell, P. K. E.; Townsend, P. A.; Mandl, D.; Ly, V. T.; Kingdon, C.; Sohlberg, R. A.; Corp, L. A.; Ong, L.; Nagol, J. R.

    2015-12-01

    This investigation contributes for bridging the gap in Earth observation between field and airborne measurements. We will reduce the risk of operating science grade instruments from Unmanned Aerial Systems (UAS), by developing robust methods to make well-characterized spectral measurements for integration, calibration and validation with NASAs science quality satellite and airborne data. Because of the potential for rapid deployment, spatially explicit data from UASs can be acquired irrespective of many of the cost, scheduling and logistic limitations to satellite or piloted aircraft missions. Provided that the measurements are suitably calibrated and well characterized, this opens up opportunities for calibration/validation activities not currently available. There is considerable interest in UASs from the agricultural and forestry industries but there is a need to identify a workflow that yields calibrated comparisons through space and time. The goal of our effort is to ensure that optical high spectral resolution measurements from UAV's are collected and processed in a fashion that allows ready integration with or comparison to NASA satellite and airborne data and derived products. We target the consistent retrieval of calibrated surface reflectance, as well as biological parameters including nutrient and chlorophyll content, chlorophyll fluorescence and photosynthetic capacity. We will test our technology and protocols first using spatially-resolved discrete point measurements characterizing canopy VNIR reflectance and solar-induced fluorescence, followed by imaging spectroscopy. A Rapid Data Assimilation and delivery system will be developed, based on SensorWeb Intelligent Payload Module for high speed onboard processing. The deployment of UAS sensors at sites such as flux towers will facilitate measrurement validation and parameter retrieval, than is possible by foot, from sensors fixed to a tower, or irregular aircraft missions. We will report preliminary results and outcomes in the project development regarding the accurate measurement of spectral reflectance at high temporal frequencies and stability to depict diurnal/seasonal cycles in vegetation function.

  5. Elder knowledge and sustainable livelihoods in post-Soviet Russia: finding dialogue across the generations.

    PubMed

    Crate, Susan A

    2006-01-01

    Russia's indigenous peoples have been struggling with economic, environmental, and socio-cultural dislocation since the fall of the Soviet Union in 1991. In northern rural areas, the end of the Soviet Union most often meant the end of agro-industrial state farm operations that employed and fed surrounding rural populations. Most communities adapted to this loss by reinstating some form of pre-Soviet household-level food production based on hunting, fishing, and/or herding. However, mass media, globalization, and modernity challenge the intergenerational knowledge exchange that grounds subsistence practices. Parts of the circumpolar north have been relatively successful in valuing and integrating elder knowledge within their communities. This has not been the case in Russia. This article presents results of an elder knowledge project in northeast Siberia, Russia that shows how rural communities can both document and use elder knowledge to bolster local definitions of sustainability and, at the same time, initiate new modes of communication between village youth and elders.

  6. EC Toolbox Project: General Findings and Some Particular Proposals--The Next Generation of Performance Indicators.

    ERIC Educational Resources Information Center

    Sumsion, John; Ward, Suzanne

    This study shows how performance measurement can be developed to take advantage of the most advanced computer software and hardware now available. The "Toolbox" study was commissioned by the European Commission (EC) and undertaken by De Montfort University in partnership with Essex County Libraries and the Library and Information Statistics Unit…

  7. 75 FR 42790 - Exelon Generation Company, LLC; Clinton Power Station; Environmental Assessment and Finding of No...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-22

    ... (NLO) staffing from two to four, allow in-plant protective actions to be performed by personnel assigned other functions, and replace a Mechanical Maintenance person with a NLO. The regulation at 10 CFR... to allow an increase in NLO staffing from two to four, allow in-plant protective actions to...

  8. 75 FR 61225 - Energy Northwest; Columbia Generating Station Environmental Assessment and Finding of No...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-04

    ... IV, Division of Operating Reactor Licensing, Office of Nuclear Reactor Regulation. BILLING CODE 7590... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY... Significant Impact The U.S. Nuclear Regulatory Commission (NRC) is considering changes to the Emergency...

  9. Generation of Ganymede's exosphere

    NASA Astrophysics Data System (ADS)

    Plainaki, Christina; Milillo, Anna; Massetti, Stefano; Mura, Alessandro; Jia, Xianzhe; Orsini, Stefano; De Angelis, Elisabetta; Mangano, Valeria; Rispoli, Rosanna

    2015-04-01

    The interactions between Jupiter's magnetospheric plasma and Ganymede's icy surface are responsible for the generation of the moon's neutral environment. Such interactions are strongly constrained by the moon's intrinsic magnetic field determining the pattern of the ion precipitation to the icy surface. In this paper, the water and oxygen exospheres of Jupiter's moon Ganymede are simulated through the application of a 3D Monte Carlo modeling technique that takes into consideration the combined effect on the exosphere generation of the main surface release processes (i.e. sputtering, sublimation and radiolysis) and the precipitation of the magnetospheric ions to the moon's surface. We find that plasma precipitation occurs in a region related to the open-closed magnetic field lines (OCFB) boundary and its extent depends on the assumption used to mimic the plasma mirroring in Jupiter's magnetosphere. In the full mirroring assumption, the primary surface sputtering mechanism at the whole polar cap of Ganymede can alone explain the observed higher albedo of this region; in the non- mirroring assumption the polar cap brightness above the OCFB ring can be explained with the action of secondary sputtering due to ionized exospheric particles re-impacting the surface. At small altitudes above the moon's subsolar point the main contribution to the neutral environment comes from sublimated water; the spatial distribution of the directly sputtered-water molecules exhibits a close correspondence with the plasma precipitation region and extends at high altitudes, being, therefore, well differentiated from the sublimated water. The oxygen exosphere comprises two different populations: a thermal one (extending to some 100s of km above the surface) and a more energetic one consisting of more energetic oxygen molecules sputtered directly from the surface after water-dissociation by ions has taken place.

  10. Minding the Generation Gap

    ERIC Educational Resources Information Center

    Field, John

    2011-01-01

    Generational conflict is back. After years of relative silence, and mutual ignorance, the young and old are once more at war. With youth unemployment high on the political agenda, the fortunes of the "jobless generation" are being contrasted with those of the "golden generation" of baby boomers, but is one generation really being mugged by the…

  11. Work Values across Generations

    ERIC Educational Resources Information Center

    Hansen, Jo-Ida C.; Leuty, Melanie E.

    2012-01-01

    Mainstream publication discussions of differences in generational cohorts in the workplace suggest that individuals of more recent generations, such as Generation X and Y, have different work values than do individuals of the Silent and Baby Boom generations. Although extant research suggests that age may influence work values, few of the…

  12. 2 CFR 200.516 - Audit findings.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    .... Criteria provide a context for evaluating evidence and understanding findings. (3) The condition found.... Known questioned costs are those specifically identified by the auditor. In evaluating the effect...

  13. Sonographic Findings in Fetal Renal Vein Thrombosis.

    PubMed

    Gerber, Rebecca E; Bromley, Bryann; Benson, Carol B; Frates, Mary C

    2015-08-01

    We present the sonographic findings of fetal renal vein thrombosis in a series of 6 patients. The mean gestational age at diagnosis was 31.2 weeks. Four cases were unilateral, and 2 were bilateral. The most common findings were renal enlargement and intrarenal vascular calcifications, followed by increased renal parenchymal echogenicity. Inferior vena cava thrombosis was found in 4 patients and common iliac vein thrombosis in 2. Fetal renal vein thrombosis is an uncommon diagnosis with characteristic sonographic findings. The presence of these findings should prompt Doppler interrogation of the renal vein and inferior vena cava to confirm the diagnosis.

  14. Gamma ray generator

    SciTech Connect

    Firestone, Richard B; Reijonen, Jani

    2014-05-27

    An embodiment of a gamma ray generator includes a neutron generator and a moderator. The moderator is coupled to the neutron generator. The moderator includes a neutron capture material. In operation, the neutron generator produces neutrons and the neutron capture material captures at least some of the neutrons to produces gamma rays. An application of the gamma ray generator is as a source of gamma rays for calibration of gamma ray detectors.

  15. 46 CFR 550.301 - Findings.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 9 2012-10-01 2012-10-01 false Findings. 550.301 Section 550.301 Shipping FEDERAL... Conditions Unfavorable to Shipping § 550.301 Findings. For the purposes of this part, conditions created by..., operators, agents or masters of foreign vessels are found unfavorable to shipping in the foreign trade...

  16. 18 CFR 4.7 - Findings.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Findings. 4.7 Section 4.7 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF... PROJECT COSTS Determination of Cost of Projects Constructed Under License § 4.7 Findings. (a)...

  17. 18 CFR 4.25 - Findings.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Findings. 4.25 Section 4.25 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF... Findings. (a) Commission determination. Final action by the Commission will be in the form of an...

  18. 18 CFR 4.25 - Findings.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Findings. 4.25 Section 4.25 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF... Findings. (a) Commission determination. Final action by the Commission will be in the form of an...

  19. 46 CFR 550.301 - Findings.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 9 2014-10-01 2014-10-01 false Findings. 550.301 Section 550.301 Shipping FEDERAL... Conditions Unfavorable to Shipping § 550.301 Findings. For the purposes of this part, conditions created by..., operators, agents or masters of foreign vessels are found unfavorable to shipping in the foreign trade...

  20. 46 CFR 550.301 - Findings.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 9 2013-10-01 2013-10-01 false Findings. 550.301 Section 550.301 Shipping FEDERAL... Conditions Unfavorable to Shipping § 550.301 Findings. For the purposes of this part, conditions created by..., operators, agents or masters of foreign vessels are found unfavorable to shipping in the foreign trade...

  1. 18 CFR 4.25 - Findings.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Findings. 4.25 Section 4.25 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF... Findings. (a) Commission determination. Final action by the Commission will be in the form of an...

  2. 18 CFR 4.7 - Findings.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Findings. 4.7 Section 4.7 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF... PROJECT COSTS Determination of Cost of Projects Constructed Under License § 4.7 Findings. (a)...

  3. 46 CFR 550.301 - Findings.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 9 2010-10-01 2010-10-01 false Findings. 550.301 Section 550.301 Shipping FEDERAL... Conditions Unfavorable to Shipping § 550.301 Findings. For the purposes of this part, conditions created by..., operators, agents or masters of foreign vessels are found unfavorable to shipping in the foreign trade...

  4. 23 CFR 669.17 - Compliance finding.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 23 Highways 1 2011-04-01 2011-04-01 false Compliance finding. 669.17 Section 669.17 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS ENFORCEMENT OF HEAVY VEHICLE USE TAX § 669.17 Compliance finding. (a) If, following the conference or...

  5. 23 CFR 669.17 - Compliance finding.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 23 Highways 1 2013-04-01 2013-04-01 false Compliance finding. 669.17 Section 669.17 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS ENFORCEMENT OF HEAVY VEHICLE USE TAX § 669.17 Compliance finding. (a) If, following the conference or...

  6. 48 CFR 30.201-6 - Findings.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Findings. 30.201-6 Section 30.201-6 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 30.201-6 Findings. See 48...

  7. 18 CFR 4.7 - Findings.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Findings. 4.7 Section 4.7 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF... PROJECT COSTS Determination of Cost of Projects Constructed Under License § 4.7 Findings. (a)...

  8. 18 CFR 4.25 - Findings.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Findings. 4.25 Section 4.25 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF... Findings. (a) Commission determination. Final action by the Commission will be in the form of an...

  9. 48 CFR 30.201-6 - Findings.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Findings. 30.201-6 Section 30.201-6 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 30.201-6 Findings. See 48...

  10. 46 CFR 550.301 - Findings.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 9 2011-10-01 2011-10-01 false Findings. 550.301 Section 550.301 Shipping FEDERAL... Conditions Unfavorable to Shipping § 550.301 Findings. For the purposes of this part, conditions created by..., operators, agents or masters of foreign vessels are found unfavorable to shipping in the foreign trade...

  11. 23 CFR 669.17 - Compliance finding.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 23 Highways 1 2014-04-01 2014-04-01 false Compliance finding. 669.17 Section 669.17 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS ENFORCEMENT OF HEAVY VEHICLE USE TAX § 669.17 Compliance finding. (a) If, following the conference or...

  12. 18 CFR 4.7 - Findings.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Findings. 4.7 Section 4.7 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF... PROJECT COSTS Determination of Cost of Projects Constructed Under License § 4.7 Findings. (a)...

  13. 48 CFR 30.201-6 - Findings.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Findings. 30.201-6 Section 30.201-6 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 30.201-6 Findings. See 48...

  14. 23 CFR 669.17 - Compliance finding.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Compliance finding. 669.17 Section 669.17 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS ENFORCEMENT OF HEAVY VEHICLE USE TAX § 669.17 Compliance finding. (a) If, following the conference or...

  15. Experimental interstellar organic chemistry - Preliminary findings

    NASA Technical Reports Server (NTRS)

    Khare, B. N.; Sagan, C.

    1973-01-01

    Review of the results of some explicit experimental simulation of interstellar organic chemistry consisting in low-temperature high-vacuum UV irradiation of condensed simple gases known or suspected to be present in the interstellar medium. The results include the finding that acetonitrile may be present in the interstellar medium. The implication of this and other findings are discussed.

  16. 48 CFR 30.201-6 - Findings.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Findings. 30.201-6 Section 30.201-6 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 30.201-6 Findings. See 48...

  17. Finding a Doctor for Your New Baby

    MedlinePlus

    ... About Zika & Pregnancy Finding a Doctor for Your New Baby KidsHealth > For Parents > Finding a Doctor for Your New Baby Print A A A Text Size What's ... recommendations. If you've recently moved to a new area, you may not have personal or social ...

  18. 20 CFR 617.33 - Findings required.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... FOR WORKERS UNDER THE TRADE ACT OF 1974 Job Search Allowances § 617.33 Findings required. (a) Findings by liable State. Before final payment of a job search allowance may be approved, the following... search allowance specified in § 617.32(a) (1) through (4); (2) The application for a job search...

  19. 20 CFR 617.33 - Findings required.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... FOR WORKERS UNDER THE TRADE ACT OF 1974 Job Search Allowances § 617.33 Findings required. (a) Findings by liable State. Before final payment of a job search allowance may be approved, the following... search allowance specified in § 617.32(a) (1) through (4); (2) The application for a job search...

  20. 38 CFR 41.510 - Audit findings.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Audit findings. 41.510 Section 41.510 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) AUDITS OF STATES, LOCAL GOVERNMENTS, AND NON-PROFIT ORGANIZATIONS Auditors § 41.510 Audit findings....

  1. 34 CFR 300.111 - Child find.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 2 2014-07-01 2013-07-01 true Child find. 300.111 Section 300.111 Education... REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN WITH DISABILITIES State Eligibility Other Fape Requirements § 300.111 Child find. (a) General. (1) The State...

  2. 34 CFR 300.111 - Child find.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 2 2013-07-01 2013-07-01 false Child find. 300.111 Section 300.111 Education... REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN WITH DISABILITIES State Eligibility Other Fape Requirements § 300.111 Child find. (a) General. (1) The State...

  3. 34 CFR 300.111 - Child find.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Child find. 300.111 Section 300.111 Education... REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN WITH DISABILITIES State Eligibility Other Fape Requirements § 300.111 Child find. (a) General. (1) The State...

  4. 34 CFR 300.111 - Child find.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 2 2011-07-01 2010-07-01 true Child find. 300.111 Section 300.111 Education... REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN WITH DISABILITIES State Eligibility Other Fape Requirements § 300.111 Child find. (a) General. (1) The State...

  5. 34 CFR 300.111 - Child find.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 2 2012-07-01 2012-07-01 false Child find. 300.111 Section 300.111 Education... REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN WITH DISABILITIES State Eligibility Other Fape Requirements § 300.111 Child find. (a) General. (1) The State...

  6. Teacher Retirement Systems: Research Findings. Research Brief

    ERIC Educational Resources Information Center

    Hansen, Janet S.; Podgursky, Michael J.; Costrell, Robert M.

    2009-01-01

    This policy brief summarizes findings presented at a February 2009 research conference on teacher retirement systems hosted by the National Center on Performance Incentives (NCPI) at Vanderbilt University's Peabody College. The 2009 conference was the second in a series of NCPI events focusing on findings from recent research on issues related to…

  7. 3 CFR - Finding and Recapturing Improper Payments

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 3 The President 1 2011-01-01 2011-01-01 false Finding and Recapturing Improper Payments Presidential Documents Other Presidential Documents Memorandum of March 10, 2010 Finding and Recapturing Improper Payments Memorandum for the Heads of Executive Departments and Agencies My Administration is committed to reducing payment errors and...

  8. 5 CFR 2638.504 - Director's finding.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 3 2013-01-01 2013-01-01 false Director's finding. 2638.504 Section 2638... Individual Executive Agency Employees § 2638.504 Director's finding. (a) In general. If the Director has... date by which the employee's comments must be submitted. (d) Employee comments. The respondent...

  9. 20 CFR 617.33 - Findings required.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... FOR WORKERS UNDER THE TRADE ACT OF 1974 Job Search Allowances § 617.33 Findings required. (a) Findings by liable State. Before final payment of a job search allowance may be approved, the following... search allowance specified in § 617.32(a) (1) through (4); (2) The application for a job search...

  10. 7 CFR 3052.510 - Audit findings.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Audit findings. 3052.510 Section 3052.510 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF THE CHIEF FINANCIAL OFFICER, DEPARTMENT OF AGRICULTURE AUDITS OF STATES, LOCAL GOVERNMENTS, AND NON-PROFIT ORGANIZATIONS Auditors § 3052.510 Audit findings. (a) Audit...

  11. 7 CFR 3052.510 - Audit findings.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Audit findings. 3052.510 Section 3052.510 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF THE CHIEF FINANCIAL OFFICER, DEPARTMENT OF AGRICULTURE AUDITS OF STATES, LOCAL GOVERNMENTS, AND NON-PROFIT ORGANIZATIONS Auditors § 3052.510 Audit findings. (a) Audit...

  12. 16 CFR 1213.7 - Findings.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Findings. 1213.7 Section 1213.7 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY STANDARD FOR ENTRAPMENT HAZARDS IN BUNK BEDS § 1213.7 Findings. The Consumer Product Safety Act requires that...

  13. 16 CFR 1301.3 - Findings.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... BINS § 1301.3 Findings. (a) Risk of injury. The Commission has studied 19 in-depth investigation... killed by refuse bins tipping over. Therefore, the Commission finds that unreasonable risks of injury or... volume one cubic yard or greater, which unreasonable risk this banning rule is designed to eliminate...

  14. 48 CFR 30.201-6 - Findings.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Findings. 30.201-6 Section 30.201-6 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Program Requirements 30.201-6 Findings. See 48...

  15. Employment for Spouses Gets Harder to Find

    ERIC Educational Resources Information Center

    June, Audrey Williams

    2009-01-01

    Worries about a partner's finding a job are a major reason why colleges lose faculty and professional-staff recruits. Some institutions have hired people to focus largely on nonfaculty job searches. (Finding faculty jobs for spouses or partners is a more complex negotiation with the university.) But as the economy continues to dip into uncharted…

  16. 5 CFR 2638.504 - Director's finding.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Director's finding. 2638.504 Section 2638... Individual Executive Agency Employees § 2638.504 Director's finding. (a) In general. If the Director has reason to believe that an employee is violating or has violated an ethics provision, the Director...

  17. 5 CFR 2638.504 - Director's finding.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 3 2011-01-01 2011-01-01 false Director's finding. 2638.504 Section 2638... Individual Executive Agency Employees § 2638.504 Director's finding. (a) In general. If the Director has reason to believe that an employee is violating or has violated an ethics provision, the Director...

  18. 5 CFR 2638.504 - Director's finding.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 3 2014-01-01 2014-01-01 false Director's finding. 2638.504 Section 2638... Individual Executive Agency Employees § 2638.504 Director's finding. (a) In general. If the Director has reason to believe that an employee is violating or has violated an ethics provision, the Director...

  19. Supersonic MHD generator system

    SciTech Connect

    Rahman, M.A.

    1983-11-29

    An improved MHD electrical power generating system of the type having a MHD topping cycle and a steam generating bottoming cycle is disclosed. The system typically includes a combustion system, a conventional MHD generator and a first diffuser radiant boiler. The improvement comprises a first supersonic MHD generator and ramjet engine configuration operatively connected in series with each other and with the conventional MHD generator. The first supersonic MHD generator and ramjet engine configuration increase the power output and improve the operating efficiency of the electrical generating system. A diffuser system is also disclosed which is in fluid communication with the supersonic MHD generator and the ramjet engine for collecting bypass plasma gas to be used for heating a second radiant boiler adapted for powering a steam turbine generator.

  20. Cylindrical neutron generator

    DOEpatents

    Leung, Ka-Ngo

    2008-04-22

    A cylindrical neutron generator is formed with a coaxial RF-driven plasma ion source and target. A deuterium (or deuterium and tritium) plasma is produced by RF excitation in a cylindrical plasma ion generator using an RF antenna. A cylindrical neutron generating target is coaxial with the ion generator, separated by plasma and extraction electrodes which contain many slots. The plasma generator emanates ions radially over 360.degree. and the cylindrical target is thus irradiated by ions over its entire circumference. The plasma generator and target may be as long as desired. The plasma generator may be in the center and the neutron target on the outside, or the plasma generator may be on the outside and the target on the inside. In a nested configuration, several concentric targets and plasma generating regions are nested to increase the neutron flux.

  1. Cylindrical neutron generator

    DOEpatents

    Leung, Ka-Ngo

    2005-06-14

    A cylindrical neutron generator is formed with a coaxial RF-driven plasma ion source and target. A deuterium (or deuterium and tritium) plasma is produced by RF excitation in a cylindrical plasma ion generator using an RF antenna. A cylindrical neutron generating target is coaxial with the ion generator, separated by plasma and extraction electrodes which contain many slots. The plasma generator emanates ions radially over 360.degree. and the cylindrical target is thus irradiated by ions over its entire circumference. The plasma generator and target may be as long as desired. The plasma generator may be in the center and the neutron target on the outside, or the plasma generator may be on the outside and the target on the inside. In a nested configuration, several concentric targets and plasma generating regions are nested to increase the neutron flux.

  2. Cylindrical neutron generator

    DOEpatents

    Leung, Ka-Ngo

    2009-12-29

    A cylindrical neutron generator is formed with a coaxial RF-driven plasma ion source and target. A deuterium (or deuterium and tritium) plasma is produced by RF excitation in a cylindrical plasma ion generator using an RF antenna. A cylindrical neutron generating target is coaxial with the ion generator, separated by plasma and extraction electrodes which contain many slots. The plasma generator emanates ions radially over 360.degree. and the cylindrical target is thus irradiated by ions over its entire circumference. The plasma generator and target may be as long as desired. The plasma generator may be in the center and the neutron target on the outside, or the plasma generator may be on the outside and the target on the inside. In a nested configuration, several concentric targets and plasma generating regions are nested to increase the neutron flux.

  3. Schooling and Inequality from Generation to Generation

    ERIC Educational Resources Information Center

    Bowles, Samuel

    1972-01-01

    Shows that substantial inequality of economic opportunity exists in the U.S. and that the educational system is a major vehicle for the transmission of economic status from one generation to the next. (RJ)

  4. 77 FR 40059 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-06

    ... reverse transcription polymerase chain reaction (RT-PCR) results by using experimental results from her...-viral factor induced-mouse iPSCs and human iPSCs generated from peripheral blood of coronary...

  5. Refrigeration generation using expander-generator units

    NASA Astrophysics Data System (ADS)

    Klimenko, A. V.; Agababov, V. S.; Koryagin, A. V.; Baidakova, Yu. O.

    2016-05-01

    The problems of using the expander-generator unit (EGU) to generate refrigeration, along with electricity were considered. It is shown that, on the level of the temperatures of refrigeration flows using the EGU, one can provide the refrigeration supply of the different consumers: ventilation and air conditioning plants and industrial refrigerators and freezers. The analysis of influence of process parameters on the cooling power of the EGU, which depends on the parameters of the gas expansion process in the expander and temperatures of cooled environment, was carried out. The schematic diagram of refrigeration generation plant based on EGU is presented. The features and advantages of EGU to generate refrigeration compared with thermotransformer of steam compressive and absorption types were shown, namely: there is no need to use the energy generated by burning fuel to operate the EGU; beneficial use of the heat delivered to gas from the flow being cooled in equipment operating on gas; energy production along with refrigeration generation, which makes it possible to create, using EGU, the trigeneration plants without using the energy power equipment. It is shown that the level of the temperatures of refrigeration flows, which can be obtained by using the EGU on existing technological decompression stations of the transported gas, allows providing the refrigeration supply of various consumers. The information that the refrigeration capacity of an expander-generator unit not only depends on the parameters of the process of expansion of gas flowing in the expander (flow rate, temperatures and pressures at the inlet and outlet) but it is also determined by the temperature needed for a consumer and the initial temperature of the flow of the refrigeration-carrier being cooled. The conclusion was made that the expander-generator units can be used to create trigeneration plants both at major power plants and at small energy.

  6. Family Finding Evaluations: A Summary of Recent Findings--Appendix. Publication #2015-01A

    ERIC Educational Resources Information Center

    Vandivere, Sharon; Malm, Karin

    2015-01-01

    This document was produced by the authors based on their research for the report, "Family Finding Evaluations: A Summary of Recent Findings. Publication #2015-01," and is an added resource for further information. The report reviews the results from 13 evaluations of Family Finding. The Family Finding model provides child welfare…

  7. Cerebral ultrasound findings in neonatal lupus syndrome.

    PubMed

    Zuppa, A A; Gallini, F; De Luca, D; Luciano, R; Frezza, S; de Turris, P L; Tortorolo, G

    2004-01-01

    A prospective study was performed enrolling 11 newborns with neonatal lupus syndrome (NLS) and 22 control newborns to investigate cerebral ultrasound (US) anomalies and their relationship with clinical neurological signs and laboratory findings. Cerebral US detected a significantly higher incidence in the study group of both subependymal pseudocysts (SEPC) and subependymal hemorrhage (SEH), neither of which correlated to autoantibody levels. All infants had completely normal neurological examinations both at birth and follow-up. The etiopathogenesis of central nervous system findings in NLS is discussed. US evaluation identified minimal anomalies compatible with favorable outcome: further studies are necessary to investigate the possible long-term sequelae, pathogenesis and spectrum of cerebral US findings.

  8. MRI findings in pediatric patients with scurvy.

    PubMed

    Gulko, Edwin; Collins, Lee K; Murphy, Robyn C; Thornhill, Beverly A; Taragin, Benjamin H

    2015-02-01

    In modern times scurvy is a rarely encountered disease caused by ascorbic acid (vitamin C) deficiency. However, sporadic cases of scurvy persist, particularly within the pediatric population. Recent individual case reports highlight an increased incidence of scurvy among patients with autism or developmental delay, with isolated case reports detailing the magnetic resonance imaging (MRI) findings of scurvy in these pediatric populations. We present the MRI findings of scurvy in four patients with autism or developmental delay, and review the literature on MRI findings in pediatric patients with scurvy. Despite its rarity, the radiologist must consider scurvy in a pediatric patient with a restricted diet presenting with arthralgia or myalgia. PMID:25109378

  9. MRI findings in pediatric patients with scurvy.

    PubMed

    Gulko, Edwin; Collins, Lee K; Murphy, Robyn C; Thornhill, Beverly A; Taragin, Benjamin H

    2015-02-01

    In modern times scurvy is a rarely encountered disease caused by ascorbic acid (vitamin C) deficiency. However, sporadic cases of scurvy persist, particularly within the pediatric population. Recent individual case reports highlight an increased incidence of scurvy among patients with autism or developmental delay, with isolated case reports detailing the magnetic resonance imaging (MRI) findings of scurvy in these pediatric populations. We present the MRI findings of scurvy in four patients with autism or developmental delay, and review the literature on MRI findings in pediatric patients with scurvy. Despite its rarity, the radiologist must consider scurvy in a pediatric patient with a restricted diet presenting with arthralgia or myalgia.

  10. MURCS association: ultrasonographic findings and pathologic correlation.

    PubMed

    Fernandez, C O; McFarland, R D; Timmons, C; Ramus, R; Twickler, D M

    1996-12-01

    MURCS association is a rare, lethal and unusual constellation of nonrandom findings that includes mullerian duct aplasia, renal aplasia, and cervicothoracic somite dysplasia.1-3 It has been described in 30 patients by Duncan and coworkers2 in 1979, in which report the authors proposed an embryologic cause for these defects.3 Antenatal ultrasonographic findings included a massive, cystic umbilical cord related to a patent urachus, enlarged bladder, single small kidney, and suspicion of urethral obstruction in a fetus of female phenotype. These findings are rare in a case of MURCS and were all confirmed on pathologic examination. PMID:8947863

  11. Diversity and Generation X.

    PubMed

    Davis, S K

    2001-09-01

    Managing Generation X (1965-1980) to be of better service to patients and organizations is a challenge for nurse managers. This article provides action scenarios that assist in understanding diversity and generations.

  12. Quantum random number generator

    DOEpatents

    Pooser, Raphael C.

    2016-05-10

    A quantum random number generator (QRNG) and a photon generator for a QRNG are provided. The photon generator may be operated in a spontaneous mode below a lasing threshold to emit photons. Photons emitted from the photon generator may have at least one random characteristic, which may be monitored by the QRNG to generate a random number. In one embodiment, the photon generator may include a photon emitter and an amplifier coupled to the photon emitter. The amplifier may enable the photon generator to be used in the QRNG without introducing significant bias in the random number and may enable multiplexing of multiple random numbers. The amplifier may also desensitize the photon generator to fluctuations in power supplied thereto while operating in the spontaneous mode. In one embodiment, the photon emitter and amplifier may be a tapered diode amplifier.

  13. Creative Test Generators

    ERIC Educational Resources Information Center

    Vickers, F. D.

    1973-01-01

    A brief description of a test generating program which generates questions concerning the Fortran programming language in a random but guided fashion and without resorting to an item bank.'' (Author/AK)

  14. Generating Customized Verifiers for Automatically Generated Code

    NASA Technical Reports Server (NTRS)

    Denney, Ewen; Fischer, Bernd

    2008-01-01

    Program verification using Hoare-style techniques requires many logical annotations. We have previously developed a generic annotation inference algorithm that weaves in all annotations required to certify safety properties for automatically generated code. It uses patterns to capture generator- and property-specific code idioms and property-specific meta-program fragments to construct the annotations. The algorithm is customized by specifying the code patterns and integrating them with the meta-program fragments for annotation construction. However, this is difficult since it involves tedious and error-prone low-level term manipulations. Here, we describe an annotation schema compiler that largely automates this customization task using generative techniques. It takes a collection of high-level declarative annotation schemas tailored towards a specific code generator and safety property, and generates all customized analysis functions and glue code required for interfacing with the generic algorithm core, thus effectively creating a customized annotation inference algorithm. The compiler raises the level of abstraction and simplifies schema development and maintenance. It also takes care of some more routine aspects of formulating patterns and schemas, in particular handling of irrelevant program fragments and irrelevant variance in the program structure, which reduces the size, complexity, and number of different patterns and annotation schemas that are required. The improvements described here make it easier and faster to customize the system to a new safety property or a new generator, and we demonstrate this by customizing it to certify frame safety of space flight navigation code that was automatically generated from Simulink models by MathWorks' Real-Time Workshop.

  15. Understanding Generation X employees.

    PubMed

    Kupperschmidt, B R

    1998-12-01

    Understanding Generation X employees--those born between 1961 and 1981--is essential if they are to be recruited into and retained in nursing and their potential maximized. The author discusses the times, characteristics, and work values and demands of Generation X. Armed with an enhanced understanding, nurse administrators are better prepared to maximize the potential of Generation X employees.

  16. Uniform random number generators

    NASA Technical Reports Server (NTRS)

    Farr, W. R.

    1971-01-01

    Methods are presented for the generation of random numbers with uniform and normal distributions. Subprogram listings of Fortran generators for the Univac 1108, SDS 930, and CDC 3200 digital computers are also included. The generators are of the mixed multiplicative type, and the mathematical method employed is that of Marsaglia and Bray.

  17. Generation and Context Memory

    ERIC Educational Resources Information Center

    Mulligan, Neil W.; Lozito, Jeffrey P.; Rosner, Zachary A.

    2006-01-01

    Generation enhances memory for occurrence but may not enhance other aspects of memory. The present study further delineates the negative generation effect in context memory reported in N. W. Mulligan (2004). First, the negative generation effect occurred for perceptual attributes of the target item (its color and font) but not for extratarget…

  18. How to Find Insects Weathering the Winter.

    ERIC Educational Resources Information Center

    Brody, Jane

    1979-01-01

    Discusses how and where to find insects and other invertebrates in winter, as well as how to collect samples in order to watch those animals reappear in spring. Includes crickets, honey bees, mosquitoes, house flies, and butterflies and moths. (MA)

  19. Finding Low-Cost Medical Care

    MedlinePlus

    ... costs and insurance requirements before you get care. Free and Low-Cost Clinics and Health Centers If ... in school), you may be able to find free or low-cost health clinics in your neighborhood. ...

  20. Anemia Boosts Stroke Death Risk, Study Finds

    MedlinePlus

    ... page: https://medlineplus.gov/news/fullstory_160476.html Anemia Boosts Stroke Death Risk, Study Finds Blood condition ... 2016 (HealthDay News) -- Older stroke victims suffering from anemia -- a lack of red blood cells -- may have ...

  1. Distinction between forensic evidence and dermatological findings.

    PubMed

    Hammer, U; Boy, D; Rothaupt, D; Büttner, A

    2015-07-01

    The external examination after death requires knowledge in forensics/pathology, dermatology, as well as associated diseases and age-related alterations of the skin. This article highlights some findings with forensic evidence versus dermatological findings. The lectures in forensic medicine should be structured interdisciplinarily, especially to dermatology, internal medicine, surgery, pathology, and toxicology in order to train the overlapping skills required for external and internal postmortem examinations. PMID:26048487

  2. How to Find the Students' Inner Geek

    ERIC Educational Resources Information Center

    Zimmer, Marc

    2005-01-01

    As a chemistry professor at a liberal-arts college, the author believes it is his job to find the youthful awe in his students and draw it out so that they will be intrigued once again by science and nature, so that they want to learn about equilibria, pH, and redox reactions. He has to go fishing inside their brains, to find, hook, and reel in…

  3. Distinction between forensic evidence and dermatological findings.

    PubMed

    Hammer, U; Boy, D; Rothaupt, D; Büttner, A

    2015-07-01

    The external examination after death requires knowledge in forensics/pathology, dermatology, as well as associated diseases and age-related alterations of the skin. This article highlights some findings with forensic evidence versus dermatological findings. The lectures in forensic medicine should be structured interdisciplinarily, especially to dermatology, internal medicine, surgery, pathology, and toxicology in order to train the overlapping skills required for external and internal postmortem examinations.

  4. Cardiomyopathy in Friedreich ataxia: clinical findings and research.

    PubMed

    Payne, R Mark; Wagner, Gregory R

    2012-09-01

    Friedreich ataxia is the most common human ataxia and results from inadequate production of the frataxin protein, most often the result of a triplet expansion in the nuclear FXN gene. The gene cannot be transcribed to generate the messenger ribonucleic acid for frataxin. Frataxin is an iron-binding protein targeted to the mitochondrial matrix. In its absence, multiple iron-sulfur-dependent proteins in mitochondria and the cytosol lack proper assembly, destroying mitochondrial and nuclear function. Mitochondrial oxidant stress may also participate in ongoing cellular injury. Although progressive and debilitative ataxia is the most prominent clinical finding, hypertrophic cardiomyopathy with heart failure is the most common cause of early death in this disease. There is no cure. In this review the authors cover recent basic and clinical findings regarding the heart in Friedreich ataxia, offer recommendations for clinical management of the cardiomyopathy in this disease, and point out new research directions to advance the field.

  5. Translating genetic findings in hereditary nephrotic syndrome: the missing loops

    PubMed Central

    Hall, Gentzon

    2015-01-01

    Nephrotic syndrome (NS) is a clinicopathological entity characterized by proteinuria, hypoalbuminemia, peripheral edema, and hyperlipidemia. It is the most common cause of glomerular disease in children and adults. Although the molecular pathogenesis of NS is not completely understood, data from the study of familial NS suggest that it is a “podocytopathy.” Virtually all of the genes mutated in hereditary NS localize to the podocyte or its secreted products and the slit diaphragm. Since the completion of human genome sequence and the advent of next generation sequencing, at least 29 causes of single-gene NS have been identified. However, these findings have not been matched by therapeutic advances owing to suboptimal in vitro and in vivo models for the study of human glomerular disease and podocyte injury phenotypes. Multidisciplinary collaboration between clinicians, geneticists, cell biologists, and molecular physiologists has the potential to overcome this barrier and thereby speed up the translation of genetic findings into improved patient care. PMID:25810439

  6. Unusual Histopathological Findings in Childhood Appendectomy Specimens.

    PubMed

    Buyukbese Sarsu, Sevgi; Ucak, Ramazan; Buyukbese, Mehmet Akif; Karakus, Suleyman Cuneyt; Deniz, Hale

    2015-12-01

    The purpose of this study was to find the unusual findings in the childhood appendectomy specimens and their incidence. The clinicopathological data of 1,306 patients whose ages ranged from 3 to 16 were retrospectively collected. Histopathological findings in appendectomy specimens taken from patients who had a prediagnosis of appendicitis were obtained. Incidental appendectomies were not included in the research. Unusual findings were reevaluated in the histopathological assessment of appendectomy specimens. The number of patients whose pathological findings are considered unusual is 25 (1.91 %). Nine of the patients were girls and 16 of them were boys. Their ages ranged from 6 to 15. Pathological results revealed that there were 16 (1.22 %) cases of parasitosis, 3 (0.23 %) cases of granulomatosis, 3 (0.23 %) cases of eosinophilic appendicitis, 2 (0.15 %) cases of carcinoid tumors, and 1 (0.08 %) case of appendiceal non-Hodgkin's lymphoma. All patients underwent a standard appendectomy. Uncommon histopathological findings in childhood appendectomy specimens are more common than those in adulthood. This kind of certain unexpected lesions of the appendix may require advanced diagnostics, careful clinical care, follow-up for years, and a multidisciplinary approach. Therefore, histopathological examinations of appendectomy specimens must be performed routinely. PMID:26730070

  7. Motor/generator

    DOEpatents

    Hickam, Christopher Dale

    2008-05-13

    A motor/generator is provided for connecting between a transmission input shaft and an output shaft of a prime mover. The motor/generator may include a motor/generator housing, a stator mounted to the motor/generator housing, a rotor mounted at least partially within the motor/generator housing and rotatable about a rotor rotation axis, and a transmission-shaft coupler drivingly coupled to the rotor. The transmission-shaft coupler may include a clamp, which may include a base attached to the rotor and a plurality of adjustable jaws.

  8. Computer-generated speech

    SciTech Connect

    Aimthikul, Y.

    1981-12-01

    This thesis reviews the essential aspects of speech synthesis and distinguishes between the two prevailing techniques: compressed digital speech and phonemic synthesis. It then presents the hardware details of the five speech modules evaluated. FORTRAN programs were written to facilitate message creation and retrieval with four of the modules driven by a PDP-11 minicomputer. The fifth module was driven directly by a computer terminal. The compressed digital speech modules (T.I. 990/306, T.S.I. Series 3D and N.S. Digitalker) each contain a limited vocabulary produced by the manufacturers while both the phonemic synthesizers made by Votrax permit an almost unlimited set of sounds and words. A text-to-phoneme rules program was adapted for the PDP-11 (running under the RSX-11M operating system) to drive the Votrax Speech Pac module. However, the Votrax Type'N Talk unit has its own built-in translator. Comparison of these modules revealed that the compressed digital speech modules were superior in pronouncing words on an individual basis but lacked the inflection capability that permitted the phonemic synthesizers to generate more coherent phrases. These findings were necessarily highly subjective and dependent on the specific words and phrases studied. In addition, the rapid introduction of new modules by manufacturers will necessitate new comparisons. However, the results of this research verified that all of the modules studied do possess reasonable quality of speech that is suitable for man-machine applications. Furthermore, the development tools are now in place to permit the addition of computer speech output in such applications.

  9. Managing the new generation.

    PubMed

    Dunn-Cane, K M; Gonzalez, J L; Stewart, H P

    1999-05-01

    As the Silent Generation quickly approaches retirement, and the Baby Boomer generation moves into management and supervisory roles, a new generation is entering the workforce. Generation Xers were born between 1965 and 1975, at a time when the country experienced high prices, wage inflation, stagnant consumer demands, and increased unemployment. Perhaps as a result, newcomers to today's workforce often have different characteristics, behavioral traits, and belief systems from their predecessors. To effectively supervise and motivate individuals from this unique generation, health care managers must begin by understanding the evolutions that have shaped each generation and influenced the workforce. In doing so, managers can create a thriving multigenerational work environment and embrace supervisory concepts that attract and motivate the new generation.

  10. Solar thermoelectric generator

    DOEpatents

    Toberer, Eric S.; Baranowski, Lauryn L.; Warren, Emily L.

    2016-05-03

    Solar thermoelectric generators (STEGs) are solid state heat engines that generate electricity from concentrated sunlight. A novel detailed balance model for STEGs is provided and applied to both state-of-the-art and idealized materials. STEGs can produce electricity by using sunlight to heat one side of a thermoelectric generator. While concentrated sunlight can be used to achieve extremely high temperatures (and thus improved generator efficiency), the solar absorber also emits a significant amount of black body radiation. This emitted light is the dominant loss mechanism in these generators. In this invention, we propose a solution to this problem that eliminates virtually all of the emitted black body radiation. This enables solar thermoelectric generators to operate at higher efficiency and achieve said efficient with lower levels of optical concentration. The solution is suitable for both single and dual axis solar thermoelectric generators.

  11. Trailblazing: Exploring First-Generation College Students' Self-Efficacy Beliefs and Academic Adjustment

    ERIC Educational Resources Information Center

    Elliott, Diane Cárdenas

    2014-01-01

    This study explored the relationship between academic self-efficacy beliefs and the academic adjustment of first-generation and non-first-generation students. Findings supported the presence of a differential relationship that was generally weaker for first-generation students. However, findings also suggested first-generation students experienced…

  12. Simple benchmark for complex dose finding studies.

    PubMed

    Cheung, Ying Kuen

    2014-06-01

    While a general goal of early phase clinical studies is to identify an acceptable dose for further investigation, modern dose finding studies and designs are highly specific to individual clinical settings. In addition, as outcome-adaptive dose finding methods often involve complex algorithms, it is crucial to have diagnostic tools to evaluate the plausibility of a method's simulated performance and the adequacy of the algorithm. In this article, we propose a simple technique that provides an upper limit, or a benchmark, of accuracy for dose finding methods for a given design objective. The proposed benchmark is nonparametric optimal in the sense of O'Quigley et al. (2002, Biostatistics 3, 51-56), and is demonstrated by examples to be a practical accuracy upper bound for model-based dose finding methods. We illustrate the implementation of the technique in the context of phase I trials that consider multiple toxicities and phase I/II trials where dosing decisions are based on both toxicity and efficacy, and apply the benchmark to several clinical examples considered in the literature. By comparing the operating characteristics of a dose finding method to that of the benchmark, we can form quick initial assessments of whether the method is adequately calibrated and evaluate its sensitivity to the dose-outcome relationships.

  13. Radiological findings in edentulous Kenyan patients.

    PubMed

    Kaimenyi, J T; Karongo, P; Ocholla, T J

    1993-03-01

    Seven hundred and seventy five files of edentulous patients seen at the Department of Dental Surgery, University of Nairobi were scrutinized for the presence or absence of routine radiographs prior to treatment. 180 (23.2%) had radiographs. 26% of the radiographs had 51 positive radiological findings. 17.3% were roots, 3.9% were unerupted teeth, 6.7% were radiopacities and 0.6% were radiolucencies. 52.9% of the radiological findings were in the mandible and 47.1% were in the maxilla. In the mandible, 44.4% of the radiological findings were in the anterior region and 55.6% were found posteriorly. 66.7% of the maxillary radiological findings were in the anterior region and 33.3% were found posteriorly. Since some of the positive radiological findings such as the retained roots and unerupted teeth might lead to infection, cysts or poor dentures fit, it is recommended that whenever possible, all edentulous patients be examined radiographically prior to treatment. PMID:8261948

  14. [Agnosia for streets and defective root finding].

    PubMed

    Takahashi, Nobuyoshi

    2011-08-01

    Topographical disorientation is identified as a condition in which patients are unable to find their way in familiar surroundings, such as their home neighborhood or the admitting hospital after the onset of illness. I proposed to classify topographical disorientation into two categories: agnosia for streets (landmark agnosia) and defective root finding (heading disorientation). Patients with agnosia for streets are unable to identify familiar buildings and landscapes. They can, however, morphologically perceive them and remember their way around familiar areas. The lesions are located in the right posterior part of the parahippocampus gyrus, anterior half of the lingual gyrus and adjacent fusiform gyrus. Clinical findings and functional imaging studies suggest that these regions play a crucial role in the interaction between the visual information of streets and memories of them, which are thought to be retained in the right anterior part of the temporal lobe. In particular, the posterior part of the parahippocampus gyrus is critical for the acquisition of novel information. On the other hand, patients with defective root finding can identify familiar streets, but cannot remember their own location or positional relation between two points within a comparatively wide range not surveyable at one time. The lesions are located in the right retrosplenial cortex (Areas 29, 30), posterior cingulate cortex (Areas 23, 31) and precuneus. Clinical findings and functional imaging studies suggest that these regions are involved in the orientation function for navigating in wide spaces. In particular, the retrosplenial cortex is critical for encoding novel information.

  15. Cytomegalovirus pneumonia in transplant patients: CT findings

    SciTech Connect

    Eun-Young Kang; Patz, E.F. Jr.; Mueller, N.L.

    1996-03-01

    Our goal was to assess the CT findings of cytomegalovirus (CMV) pneumonia in transplant patients. The study included 10 transplant patients who had chest CT scan and pathologically proven isolated pulmonary CMV infection. Five patients had bone marrow transplant and five had solid organ transplant. The CT scans were retrospectively reviewed for pattern and distribution of disease and the CT findings compared with the findings on open lung biopsy (n = 9) and autopsy (n = 1). Nine of 10 patients had parenchymal abnormalities apparent at CT and I had normal CT scans. The findings in the nine patients included small nodules (n = 6), consolidation (n = 4), ground-glass attenuation (n = 4), and irregular lines (n = 1). The nodules had a bilateral and symmetric distribution and involved all lung zones. The consolidation was most marked in the lower lung zones. The CT findings of CMV pneumonia in transplant patients are heterogeneous. The most common patterns include small nodules and areas of consolidation. 13 refs., 4 figs., 1 tab.

  16. Multiblock grid generation for jet engine configurations

    NASA Technical Reports Server (NTRS)

    Stewart, Mark E. M.

    1992-01-01

    The goal was to create methods for generating grids with minimal human intervention that are applicable to a wide range of problems and compatible with existing numerical methods and with existing and proposed computers. The following topics that are related to multiblock grid generation are briefly covered in viewgraph form: finding a domain decomposition, dimensioning grids, grid smoothing, manipulating grids and decompositions, and some specializations for jet engine configurations.

  17. Educational Research: Biologists Finding Their Voice

    ERIC Educational Resources Information Center

    Orsmond, Paul

    2007-01-01

    Since the publication of the Dearing report (1997) there has been an increasing emphasis on the quality of teaching and learning provision within higher education institutions (HEIs). This focus on provision has in turn generated much educational research into "approaches" to both teaching practice and student learning within higher education…

  18. Find Your Image between the Extremes

    ERIC Educational Resources Information Center

    Gordon, Rachel Singer

    2004-01-01

    Librarians' unfortunate fixation on image as a defining generational characteristic also makes them just as guilty of promoting misconceptions as nonlibrarians. Can the profession stand another article in the general press that trumpets the amazing new discovery that librarians can be young, trendy, stylish? The level of our colleagues'…

  19. 77 FR 76491 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-28

    ... HPLC data that he had plagiarized, originally generated prior to the Respondent's arrival in the laboratory by a former postdoctoral researcher; in Figure 2(c), the Respondent claimed that the HPLC... plasma, and similarly in Figure 3(c), the Respondent claimed that the HPLC chromatogram was of a...

  20. Parent status and generativity within the context of race.

    PubMed

    Newton, Nicky J; Baltys, Izora H

    2014-01-01

    Generativity, or providing for the next generation (Erikson, 1950), is usually associated with midlife, and related to parenting. However, the extent to which grandparenting or non-parenting are associated with generativity, especially within the context of race, is less well known. The current study uses narrative data from the Foley Longitudinal Study of Adulthood (FLSA; N = 150) to examine the relationship between generativity and parent status--parents, grandparents, as well as non-parents--in midlife African Americans and Whites. Responses to questions concerning future plans in Life Story narratives were coded for four subtypes of generative expression: general generativity, productive generativity, generative caring, and generative need to be needed; these subtypes of generativity were associated with parent status in different ways for middle-aged men and women of each race group. The findings highlight the importance of context, providing a glimpse of expressions of generativity at the intersection of parent status and race. PMID:24956924

  1. For a Dialogue on Relations between the Generations

    ERIC Educational Resources Information Center

    Lisovskii, Vladimir Timofeevich

    2004-01-01

    This article reports the findings of a study examining how young people in Russia rate themselves and their parents' generation. The sociological survey was carried out in 1999 and 2001 in a number of big and small towns of Russia. The focus of the study was on three generations: the "generation of the 1960s" (children of the thaw); children of…

  2. Autopsy findings in botulinum toxin poisoning.

    PubMed

    Devers, Kelly G; Nine, Jeffrey S

    2010-11-01

    In the United States, foodborne botulism is most commonly associated with home-canned food products. Between 1950 and 2005, 405 separate outbreaks of botulism were reported to the Centers for Disease Control and Prevention (CDC). Approximately 8% of these outbreaks were attributed to commercially produced canned food products. Overall, 5-10% of persons ingesting botulinum toxin die. Few reports exist pertaining to autopsy findings in cases of foodborne botulism. Here, we report the autopsy findings of a man who died after a prolonged illness caused by botulinum toxin exposure likely attributable to a commercially prepared food source. Despite extensive testing, our histopathologic findings were nonspecific. We therefore conclude that the forensic pathologist must become familiar with the neurotoxicity syndrome associated with this illness. Maintaining vigilance for botulism by carefully reviewing the decedent's clinical history will aid in the early identification and control of outbreaks, either foodborne or terrorism-related.

  3. Acute pancreatitis: clinical vs. CT findings

    SciTech Connect

    Hill, M.C.; Barkin, J.; Isikoff, M.B.; Silver stein, W.; Kalser, M.

    1982-08-01

    In a prospective study of 91 patients with acute pancreatitis, computed tomographic (CT) findings were correlated with the clinical type of acute pancreatitis. In acute edematous pancreatitis (63 patients; 16 with repeat CT), CT was normal (28%) or showed inflammation limited to the pancreas (61%). Phlegmonous changes were present in 11%, including one patient with focal pancreatic hemorrhage, indicating that clinically unsuspected hemorrhagic pancreatitis can occur. In acute necrotizing (hemorrhagic, suppurative) pancreatitis (nine patients; eight with repeat CT), no patient had a normal CT scan and 89% had phlegmonous changes. One patient had hemorrhagic pancreatitis and three had abscesses. In acute exacerbation of chronic pancreatitis (10 patients; three with repeat CT), there were pancreatic calcifications (70%), a focal mass (40%), and pancreatic ductal dilation (30%). On follow-up CT, the findings of acute pancreatitis did not always disappear with resolution of the clinical symptons. This was especialy true of phlegmonous pancreatitis, where the CT findings could persist for months.

  4. Hallux valgus and hallux rigidus: MRI findings.

    PubMed

    Schweitzer, M E; Maheshwari, S; Shabshin, N

    1999-01-01

    The purpose of this article is to describe the MR findings of Hallux Valgus (HV) and Hallux Rigidus (HR). Twenty-four patients (11 with HV, 4 with HR, and 9 with both HV and HR) were studied at 1.5 Tesla MRI. Two separate observers evaluated the first ray blindly for the following signs: sesamoid position, sesamoid proliferation, hypertrophy of the median eminence, presence of a lateral facet, presence of an adventitial bursa, shape of the first metatarsal head, relative length of the first metatarsal, joint space loss, osteophytes (dorsalor lateral), marrow edema, geodes, subchondral sclerosis, intra-articular ossicle, and pes planus. The most common findings observed in HV were a hypertrophic medial eminence (95%), sesamoid proliferation (90%) and adventitial bursitis (70%). The most common findings observed in HR were osteophytes (77% and 69%), geodes, and marrow edema. We conclude that traditional routine radiograph signs of HV and HR may be applied to MR images.

  5. Scurvy in an autistic child: MRI findings.

    PubMed

    Gongidi, Preetam; Johnson, Craig; Dinan, David

    2013-10-01

    Scurvy results from a deficiency of vitamin C and is rarely seen in the United States. We describe the MRI findings of a case of scurvy in an autistic child with food-avoidant behavior. Advanced imaging is rarely performed in clinically well-understood disease entities such as scurvy. Typical radiographic findings are well described leading to definitive diagnosis, although the findings can be missed or misinterpreted given the rarity of scurvy in daily practice. To our knowledge, MRI features of scurvy in children in the US have been described in only one case report. This case of scurvy in an autistic child with food-avoidant behavior emphasizes that classic nutritional deficiencies, despite their rarity, must be included in the differential diagnosis of at-risk populations. PMID:23604286

  6. Scurvy in an autistic child: MRI findings.

    PubMed

    Gongidi, Preetam; Johnson, Craig; Dinan, David

    2013-10-01

    Scurvy results from a deficiency of vitamin C and is rarely seen in the United States. We describe the MRI findings of a case of scurvy in an autistic child with food-avoidant behavior. Advanced imaging is rarely performed in clinically well-understood disease entities such as scurvy. Typical radiographic findings are well described leading to definitive diagnosis, although the findings can be missed or misinterpreted given the rarity of scurvy in daily practice. To our knowledge, MRI features of scurvy in children in the US have been described in only one case report. This case of scurvy in an autistic child with food-avoidant behavior emphasizes that classic nutritional deficiencies, despite their rarity, must be included in the differential diagnosis of at-risk populations.

  7. Radiographic findings in congenital lead poisoning

    SciTech Connect

    Pearl, M.; Boxt, L.M.

    1980-07-01

    Because lead crosses the placenta throughout pregnancy, the fetus is at risk for lead poisoning. A full term, asymptomatic child was born with congenital lead poisoning secondary to maternal pica. Radiographic findings of a dense cranial vault, lead lines, and delayed skeletal and deciduous dental development were noted at birth. After chelation therapy, when the patient was seven months old, radiographs revealed normal skeletal maturation. Tooth eruption did not occur until 15 months of age. Newborn infants with these radiographic findings should be screened for subclinical, congenital lead poisoning.

  8. FIND: Fluorescence Imaging in the Nuclear Domain

    SciTech Connect

    Barty, C J

    2005-02-14

    This document examines the potential use of Thomson-Radiated Extreme X-ray (T-REX) sources for Fluorescence Imaging in the Nuclear Domain (FIND) of special nuclear materials. A back-of-the-envelope, relative comparison of T-REX sources vs. Bremsstrahlung sources for this application is presented. It is estimated that use of T-REX for FIND could be as much as 5 x 10{sup 12} more effective than the use of anode based sources. Furthermore it is estimated that illumination of samples of dimension 1 cm on a side could produce up to {approx}10{sup 9} detectable photons per second.

  9. Ivory vertebra: imaging findings in different diagnoses.

    PubMed

    Braun, Richard Andreas; Milito, Carlos Felipe do Rego Barros; Goldman, Suzan Menasce; Fernandes, Eloy de Ávila

    2016-01-01

    Low back pain is often managed at all levels of healthcare. In general, diagnostic investigation begins with radiography of the lumbar spine. In addition to the most common findings, radiologists can identify increased density of a vertebral body, referred to as ivory vertebra. The objective of this study was to describe the main diseases that can present with this radiologic sign, such as Hodgkin lymphoma, Paget's disease, metastatic prostate cancer, breast cancer, and osteomyelitis. It is extremely important that radiologists be aware of this finding in order to inform the requesting physician of the possible etiologies, given that it can be the initial radiologic presentation for these diseases. PMID:27141135

  10. Ivory vertebra: imaging findings in different diagnoses.

    PubMed

    Braun, Richard Andreas; Milito, Carlos Felipe do Rego Barros; Goldman, Suzan Menasce; Fernandes, Eloy de Ávila

    2016-01-01

    Low back pain is often managed at all levels of healthcare. In general, diagnostic investigation begins with radiography of the lumbar spine. In addition to the most common findings, radiologists can identify increased density of a vertebral body, referred to as ivory vertebra. The objective of this study was to describe the main diseases that can present with this radiologic sign, such as Hodgkin lymphoma, Paget's disease, metastatic prostate cancer, breast cancer, and osteomyelitis. It is extremely important that radiologists be aware of this finding in order to inform the requesting physician of the possible etiologies, given that it can be the initial radiologic presentation for these diseases.

  11. Preliminary Airspace Operations Simulations Findings Report

    NASA Technical Reports Server (NTRS)

    2005-01-01

    Provides preliminary findings of the initial series (normal operations and contingency management) of airspace operations simulations. The key elements of this report discuss feedback from controller subjects for UAS flight above FL430. Findings provide initial evaluation of routine UAS operations above dense ARTCC airspace (ZOB), and identify areas of further research, policy direction and procedural development. This document further serves as an addendum to the detailed AOS simulation plan (Deliverable SIM001), incorporating feedback from FAA air traffic personnel and Access 5 IPTs.

  12. Ivory vertebra: imaging findings in different diagnoses*

    PubMed Central

    Braun, Richard Andreas; Milito, Carlos Felipe do Rego Barros; Goldman, Suzan Menasce; Fernandes, Eloy de Ávila

    2016-01-01

    Low back pain is often managed at all levels of healthcare. In general, diagnostic investigation begins with radiography of the lumbar spine. In addition to the most common findings, radiologists can identify increased density of a vertebral body, referred to as ivory vertebra. The objective of this study was to describe the main diseases that can present with this radiologic sign, such as Hodgkin lymphoma, Paget's disease, metastatic prostate cancer, breast cancer, and osteomyelitis. It is extremely important that radiologists be aware of this finding in order to inform the requesting physician of the possible etiologies, given that it can be the initial radiologic presentation for these diseases. PMID:27141135

  13. Ultrasound findings in dengue haemorrhagic fever.

    PubMed

    Pramuljo, H S; Harun, S R

    1991-01-01

    The ultrasound examination of 29 children, aged between 2 to 13 years with clinical and serological proven dengue haemorrhagic fever were reviewed and correlated with the findings in the literature. Ultrasound findings consisted of: (1) ascites, (2) pleural effusion, (3) abnormal gallbladder wall and (4) abnormal liver parenchyma. Ascites is common in DHF. Pleural effusion was found on the right and on bilateral pleural spaces. There was no isolated left pleural effusions. The abnormal gallbladder wall has never been mentioned before in the literature and the abnormal liver parenchyma might be due to intraparenchymal and subcapsular haemorrhages.

  14. Finding Objects for Assisting Blind People

    PubMed Central

    Yi, Chucai; Flores, Roberto W.; Chincha, Ricardo; Tian, YingLi

    2013-01-01

    Computer vision technology has been widely used for blind assistance, such as navigation and wayfinding. However, few camera-based systems are developed for helping blind or visually-impaired people to find daily necessities. In this paper, we propose a prototype system of blind-assistant object finding by camera-based network and matching-based recognition. We collect a dataset of daily necessities and apply Speeded-Up Robust Features (SURF) and Scale Invariant Feature Transform (SIFT) feature descriptors to perform object recognition. Experimental results demonstrate the effectiveness of our prototype system. PMID:23894729

  15. Pathological findings in the Hawaiian monk seal.

    PubMed

    Banish, L D; Gilmartin, W G

    1992-07-01

    Postmortem examinations were performed on 45 Hawaiian monk seals (Monachus schauinslandi) collected during field research on the beaches of the Northwestern Hawaiian Islands (USA) from 1981 to 1985. Both males and females of all age groups, perinatal through adult, were examined. Frequent findings included parasites, trauma, cardiovascular disease (congenital and acquired), and respiratory infections. Emaciation was a common condition. All animals except neonates were infected with parasites; infection was severe in several cases. Splenic hematopoiesis was a universal histopathologic finding. Some cases exhibited lesions consistent with renal, gastrointestinal, and toxic disorders; ectopic tissue calcification; gallstones; and ophthalmologic and dental problems. PMID:1512875

  16. Microorganisms from Permafrost Viable and Detectable by 16SRNA Analysis: A Model for Mars

    NASA Technical Reports Server (NTRS)

    Tsapin, A. I.; McDonald, G. D.; Andrews, M.; Bhartia, R.; Douglas, S.; Gilichinsky, D.

    1999-01-01

    Preliminary studies of Arctic and Antarctic permafrost have shown that this environment harbors microorganisms which can be isolated in pure culture, and that these organisms can survive for a long period of time (up to 20 Ma) in permafrost. It is believed that the permanent subzero temperatures in permafrost and ice environments are the main parameters ensuring the longevity of microbes. In this project we studied permafrost cores from different areas of the Siberian Arctic and Antarctic, with ages from several thousand years up to several millions years (Ma). In general, Antarctic permafrost has a higher sand content, while Siberian permafrost has a texture more characteristic of clay or normal soil. Additional information is contained in the original extended abstract.

  17. A new custom microarray for sRNA profiling in Escherichia coli.

    PubMed

    Ruiz-Larrabeiti, Olatz; Plágaro, Ander Hernández; Gracia, Celine; Sevillano, Elena; Gallego, Lucía; Hajnsdorf, Eliane; Kaberdin, Vladimir R

    2016-07-01

    Bacterial small RNAs (sRNAs) play essential roles in the post-transcriptional control of gene expression. To improve their detection by conventional microarrays, we designed a custom microarray containing a group of probes targeting known and some putative Escherichia coli sRNAs. To assess its potential in detection of sRNAs, RNA profiling experiments were performed with total RNA extracted from E. coli MG1655 cells exponentially grown in rich (Luria-Bertani) and minimal (M9/glucose) media. We found that many sRNAs could yield reasonably strong and statistically significant signals corresponding to nearly all sRNAs annotated in the EcoCyc database. Besides differential expression of two sRNAs (GcvB and RydB), expression of other sRNAs was less affected by the composition of the growth media. Other examples of the differentially expressed sRNAs were revealed by comparing gene expression of the wild-type strain and its isogenic mutant lacking functional poly(A) polymerase I (pcnB). Further, northern blot analysis was employed to validate these data and to assess the existence of new putative sRNAs. Our results suggest that the use of custom microarrays with improved capacities for detection of sRNAs can offer an attractive opportunity for efficient gene expression profiling of sRNAs and their target mRNAs at the whole transcriptome level. PMID:27190161

  18. New tools for discovering the role sRNA plays in cellular regulation

    NASA Astrophysics Data System (ADS)

    Shepherd, Douglas P.; Li, Nan; Hong-Geller, Elizabeth; Munsky, Brian; Werner, James H.

    2012-02-01

    We have used single molecule fluorescence in situ hybridization (smFISH) to study cell-to-cell heterogeneity of messenger RNA (mRNA) copy numbers for human host cells subject to a variety of external stimuli. In order to study the effect of various stimuli and genetic modifications on mRNA copy number, we have constructed an automated highthroughput multiplexed imaging system and data analysis package capable of localizing large numbers of individual mRNA transcripts in three dimensions. These experimental distributions of mRNA are used to refine and down-select regulatory models. Here we present a case example of Interleukin 1 alpha mRNA production in response to immune system stimulation. We propose a methodology for extending these methods to study the effect of small RNA on genetic expression by combining multiplexed imaging and numerical modeling at the system-level.

  19. Transcript analysis of nrrF, a Fur repressed sRNA of Neisseria gonorrhoeae

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Like most microorganisms, Neisseria gonorrhoeae alters gene expression in response to iron availability. The ferric uptake regulator Fur has been shown to be involved in controlling this response, but the extent of this involvement remains unknown. It is known that in addition to working directly to...

  20. Steam generator support system

    DOEpatents

    Moldenhauer, James E.

    1987-01-01

    A support system for connection to an outer surface of a J-shaped steam generator for use with a nuclear reactor or other liquid metal cooled power source. The J-shaped steam generator is mounted with the bent portion at the bottom. An arrangement of elongated rod members provides both horizontal and vertical support for the steam generator. The rod members are interconnected to the steam generator assembly and a support structure in a manner which provides for thermal distortion of the steam generator without the transfer of bending moments to the support structure and in a like manner substantially minimizes forces being transferred between the support structure and the steam generator as a result of seismic disturbances.

  1. Steam generator support system

    DOEpatents

    Moldenhauer, J.E.

    1987-08-25

    A support system for connection to an outer surface of a J-shaped steam generator for use with a nuclear reactor or other liquid metal cooled power source is disclosed. The J-shaped steam generator is mounted with the bent portion at the bottom. An arrangement of elongated rod members provides both horizontal and vertical support for the steam generator. The rod members are interconnected to the steam generator assembly and a support structure in a manner which provides for thermal distortion of the steam generator without the transfer of bending moments to the support structure and in a like manner substantially minimizes forces being transferred between the support structure and the steam generator as a result of seismic disturbances. 4 figs.

  2. Method of grid generation

    DOEpatents

    Barnette, Daniel W.

    2002-01-01

    The present invention provides a method of grid generation that uses the geometry of the problem space and the governing relations to generate a grid. The method can generate a grid with minimized discretization errors, and with minimal user interaction. The method of the present invention comprises assigning grid cell locations so that, when the governing relations are discretized using the grid, at least some of the discretization errors are substantially zero. Conventional grid generation is driven by the problem space geometry; grid generation according to the present invention is driven by problem space geometry and by governing relations. The present invention accordingly can provide two significant benefits: more efficient and accurate modeling since discretization errors are minimized, and reduced cost grid generation since less human interaction is required.

  3. Quantum random number generation

    DOE PAGES

    Ma, Xiongfeng; Yuan, Xiao; Cao, Zhu; Zhang, Zhen; Qi, Bing

    2016-06-28

    Here, quantum physics can be exploited to generate true random numbers, which play important roles in many applications, especially in cryptography. Genuine randomness from the measurement of a quantum system reveals the inherent nature of quantumness -- coherence, an important feature that differentiates quantum mechanics from classical physics. The generation of genuine randomness is generally considered impossible with only classical means. Based on the degree of trustworthiness on devices, quantum random number generators (QRNGs) can be grouped into three categories. The first category, practical QRNG, is built on fully trusted and calibrated devices and typically can generate randomness at amore » high speed by properly modeling the devices. The second category is self-testing QRNG, where verifiable randomness can be generated without trusting the actual implementation. The third category, semi-self-testing QRNG, is an intermediate category which provides a tradeoff between the trustworthiness on the device and the random number generation speed.« less

  4. Steam generator performance degradation

    SciTech Connect

    Lovett, J.T.; Dow, B.L. )

    1991-09-01

    A survey was conducted to determine the range and severity of steam generator performance degradation effects experienced by PWRs in the United States. The survey results were tabulated and correlated with steam generator age and design. Operating experience at several PWRs was examined in detail. The operating experience at US PWRs was compared to that of PWRs in Japan and Germany. Possible causes for the performance degradation were postulated and evaluated. The sensitivity of steam generator output pressure to changes in various parameters (such as fouling factor, average reactor coolant temperature, and percentage of steam generator tubes plugged) was calculated. These calculations were used in the evaluation of possible causes of steam generator performance degradation. Several deposit exfoliation scenarios were evaluated in terms of the calculated effect on fouling factor trends and associated steam generator output pressure trends. 15 refs., 32 figs., 7 tabs.

  5. Solar fuels generator

    DOEpatents

    Lewis, Nathan S.; Spurgeon, Joshua M.

    2016-10-25

    The solar fuels generator includes an ionically conductive separator between a gaseous first phase and a second phase. A photoanode uses one or more components of the first phase to generate cations during operation of the solar fuels generator. A cation conduit is positioned provides a pathway along which the cations travel from the photoanode to the separator. The separator conducts the cations. A second solid cation conduit conducts the cations from the separator to a photocathode.

  6. Distributed generation systems model

    SciTech Connect

    Barklund, C.R.

    1994-12-31

    A slide presentation is given on a distributed generation systems model developed at the Idaho National Engineering Laboratory, and its application to a situation within the Idaho Power Company`s service territory. The objectives of the work were to develop a screening model for distributed generation alternatives, to develop a better understanding of distributed generation as a utility resource, and to further INEL`s understanding of utility concerns in implementing technological change.

  7. Modular Stirling Radioisotope Generator

    NASA Technical Reports Server (NTRS)

    Schmitz, Paul C.; Mason, Lee S.; Schifer, Nicholas A.

    2016-01-01

    High-efficiency radioisotope power generators will play an important role in future NASA space exploration missions. Stirling Radioisotope Generators (SRGs) have been identified as a candidate generator technology capable of providing mission designers with an efficient, high-specific-power electrical generator. SRGs high conversion efficiency has the potential to extend the limited Pu-238 supply when compared with current Radioisotope Thermoelectric Generators (RTGs). Due to budgetary constraints, the Advanced Stirling Radioisotope Generator (ASRG) was canceled in the fall of 2013. Over the past year a joint study by NASA and the Department of Energy (DOE) called the Nuclear Power Assessment Study (NPAS) recommended that Stirling technologies continue to be explored. During the mission studies of the NPAS, spare SRGs were sometimes required to meet mission power system reliability requirements. This led to an additional mass penalty and increased isotope consumption levied on certain SRG-based missions. In an attempt to remove the spare power system, a new generator architecture is considered, which could increase the reliability of a Stirling generator and provide a more fault-tolerant power system. This new generator called the Modular Stirling Radioisotope Generator (MSRG) employs multiple parallel Stirling convertor/controller strings, all of which share the heat from the General Purpose Heat Source (GPHS) modules. For this design, generators utilizing one to eight GPHS modules were analyzed, which provided about 50 to 450 W of direct current (DC) to the spacecraft, respectively. Four Stirling convertors are arranged around each GPHS module resulting in from 4 to 32 Stirling/controller strings. The convertors are balanced either individually or in pairs, and are radiatively coupled to the GPHS modules. Heat is rejected through the housing/radiator, which is similar in construction to the ASRG. Mass and power analysis for these systems indicate that specific

  8. 78 FR 5454 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-25

    ... HUMAN SERVICES Office of the Secretary Findings of Research Misconduct AGENCY: Office of the Secretary, HHS. ACTION: Notice. SUMMARY: Notice is hereby given that the Office of Research Integrity (ORI) has..., Department of Neurological Surgery, UW, engaged in research misconduct by falsifying results in...

  9. 76 FR 23600 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-27

    ... HUMAN SERVICES Office of the Secretary Findings of Research Misconduct AGENCY: Office of the Secretary, HHS. ACTION: Notice. SUMMARY: Notice is hereby given that the Office of Research Integrity (ORI) has... Office of Research Integrity (ORI) in its oversight review, the U.S. Public Health Service (PHS)...

  10. 77 FR 5254 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-02

    ... HUMAN SERVICES Office of the Secretary Findings of Research Misconduct AGENCY: Office of the Secretary, HHS. ACTION: Notice. SUMMARY: Notice is hereby given that the Office of Research Integrity (ORI) has... obtained from Creighton University (CU) and additional evidence gathered by the Office of...

  11. 77 FR 69627 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-20

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Office of the Secretary Findings of Research Misconduct AGENCY: Office of the Secretary, HHS. ACTION: Notice. SUMMARY: Notice is hereby given that the Office of Research Integrity (ORI)...

  12. Pneumoconiosis: comparison of imaging and pathologic findings

    SciTech Connect

    Semin Chong; Kyung Soo Lee; Myung Jin Chung; Joungho Han; O. Jung Kwon; d Tae Sung Kim

    2006-01-15

    Pneumoconiosis may be classified as either fibrotic or nonfibrotic, according to the presence or absence of fibrosis. Silicosis, coal worker pneumoconiosis, asbestosis, berylliosis, and talcosis are examples of fibrotic pneumoconiosis. Siderosis, stannosis, and baritosis are nonfibrotic forms of pneumoconiosis that result from inhalation of iron oxide, tin oxide, and barium sulfate particles, respectively. In an individual who has a history of exposure to silica or coal dust, a finding of nodular or reticulonodular lesions at chest radiography or small nodules with a perilymphatic distribution at thin-section computed tomography (CT), with or without eggshell calcifications, is suggestive of silicosis or coal worker pneumoconiosis. Magnetic resonance imaging is helpful for distinguishing between progressive massive fibrosis and lung cancer. CT and histopathologic findings in asbestosis are similar to those in idiopathic pulmonary fibrosis, but the presence of asbestos bodies in histopathologic specimens is specific for the diagnosis of asbestosis. Giant cell interstitial pneumonia due to exposure to hard metals is classified as a fibrotic form of pneumoconiosis and appears on CT images as mixed ground-glass opacities and reticulation. Berylliosis simulates pulmonary sarcoidosis on CT images. CT findings in talcosis include small centrilobular and subpleural nodules or heterogeneous conglomerate masses that contain foci of high attenuation indicating talc deposition. Siderosis is nonfibrotic and is indicated by a CT finding of poorly defined centrilobular nodules or ground-glass opacities.

  13. Pneumoconiosis: Comparison of imaging and pathologic findings

    SciTech Connect

    Chong, S.; Lee, K.S.; Chung, M.J.; Han, J.H.; Kwon, O.J.; Kim, T.S.

    2006-01-15

    Pneumoconiosis may be classified as either fibrotic or nonfibrotic, according to the presence or absence of fibrosis. Silicosis, coal worker pneumoconiosis, asbestosis, berylliosis, and talcosis are examples of fibrotic pneumoconiosis. Siderosis, stannosis, and baritosis are nonfibrotic forms of pneumoconiosis that result from inhalation of iron oxide, tin oxide, and barium sulfate particles, respectively. In an individual who has a history of exposure to silica or coal dust, a finding of nodular or reticulonodular lesions at chest radiography or small nodules with a perilymphatic distribution at thin-section computed tomography (CT), with or without eggshell calcifications, is suggestive of silicosis or coal worker pneumoconiosis. Magnetic resonance imaging is helpful for distinguishing between progressive massive fibrosis and lung cancer. CT and histopathologic findings in asbestosis are similar to those in idiopathic pulmonary fibrosis, but the presence of asbestos bodies in histopathologic specimens is specific for the diagnosis of asbestosis. Giant cell interstitial pneumonia due to exposure to hard metals is classified as a fibrotic form of pneumoconiosis and appears on CT images as mixed ground-glass opacities and reticulation. Berylliosis simulates pulmonary sarcoidosis on CT images. CT findings in talcosis include small centrilobular and subpleural nodules or heterogeneous conglomerate masses that contain foci of high attenuation indicating talc deposition. Siderosis is nonfibrotic and is indicated by a CT finding of poorly defined centrilobular nodules or ground-glass opacities.

  14. Web Usability Test Findings and Analysis Issues.

    ERIC Educational Resources Information Center

    An, Jae Soon; Park, Su-Hong; Baek, Eun-Ok

    This paper discusses findings and data analysis issues that resulted from a case usability test. The case usability test was conducted as part of a redesign project that aimed to update the existing home page of Indiana University Bloomington. The home page contained links to the Web sites that various institutions in the university had already…

  15. Garage Sale Finds = Equal = Classroom Treasures.

    ERIC Educational Resources Information Center

    Warner, Laverne; Payne, Pam

    2001-01-01

    Offers tips for using garage sales and other community sources for obtaining inexpensive classroom materials. Lists potential finds at yard sales and thrift shops. Suggestions include setting up a budget before shopping, recognizing the educational value of real objects for young children, and taking health and safety precautions before…

  16. Finding More Joy in Teaching Children

    ERIC Educational Resources Information Center

    Baumgartner, Jennifer J.; DiCarlo, Cynthia F.; Apavaloaie, Loredana

    2011-01-01

    Early childhood professionals are familiar with finding and appreciating daily moments of joy. Teachers smile inside and out when toddlers are able to pull up their own pants, preschoolers write their names for the first time, or kindergarteners figure out how to make complicated patterns with blocks. Working with young children can also be very…

  17. Staff Development: Finding the Right Fit

    ERIC Educational Resources Information Center

    Standerfer, Leslie

    2005-01-01

    Three years ago, when the author joined the staff of Agua Fria High School in Phoenix, Arizona, as an assistant principal, she was excited to find that the students' school day started an hour and a half later than normal each Wednesday to provide staff development time for the teaching staff. That first year, however, neither the principal, Bryce…

  18. Questions That Science Teachers Find Difficult (II).

    ERIC Educational Resources Information Center

    Goodwin, Alan

    2003-01-01

    Presents some questions that science teachers find difficult. Focuses on three further questions relating to "simple" everyday situations that are normally explained in terms of the kinetic theory of matter. Identifies looking at the difference between chemical and physical changes as the most problematic question. (Author/YDS)

  19. 16 CFR 1210.5 - Findings.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... and to include the findings in the rule. (a) The degree and nature of the risk of injury the rule is designed to eliminate or reduce. The standard is designed to reduce the risk of death and injury from... intended for use in lighting cigarettes and other smoking materials. Lighters may be gas- or...

  20. 16 CFR 1210.5 - Findings.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... and to include the findings in the rule. (a) The degree and nature of the risk of injury the rule is designed to eliminate or reduce. The standard is designed to reduce the risk of death and injury from... intended for use in lighting cigarettes and other smoking materials. Lighters may be gas- or...

  1. Art Works ... when Students Find Inspiration

    ERIC Educational Resources Information Center

    Herberholz, Barbara

    2011-01-01

    Artworks are not produced in a vacuum, but by the interaction of experiences, and interrelationships of ideas, perceptions and feelings acknowledged and expressed in some form. Students, like mature artists, may be inspired and motivated by their memories and observations of their surroundings. Like adult artists, students may find that their own…

  2. World Fertility Survey: Major Findings and Implications.

    ERIC Educational Resources Information Center

    World Fertility Survey, London (England).

    A survey was conducted in 42 developing countries and in 20 developed countries to determine fertility practices and trends. Both individual and household questionnaires were used by interviewers to gather data. Findings concerning marriage patterns, contraception, reproductive motivation, childspacing, breastfeeding, maternal and child health,…

  3. Studies Find Vocabulary Instruction Is Falling Short

    ERIC Educational Resources Information Center

    Sparks, Sarah D.

    2013-01-01

    Children who enter kindergarten with a small vocabulary don't get taught enough words--particularly, sophisticated academic words--to close the gap, according to the latest in a series of studies by Michigan early-learning experts. The findings suggest many districts could be at a disadvantage in meeting the increased requirements for vocabulary…

  4. Counselor Training: Empirical Findings and Current Approaches

    ERIC Educational Resources Information Center

    Buser, Trevor J.

    2008-01-01

    The literature on counselor training has included attention to cognitive and interpersonal skill development and has reported on empirical findings regarding the relationship of training with client outcomes. This article reviews the literature on each of these topics and discusses empirical and theoretical underpinnings of recently developed…

  5. Child Find Practices in Christian Schools

    ERIC Educational Resources Information Center

    Lane, Julie M.; Jones, David R.

    2015-01-01

    The 1997 Amendments of the Individuals with Disabilities Education Act (IDEA) states that children placed in private schools by their parents are no longer afforded the right to special education services. However, IDEA does state that child find activities between public school representatives and private schools are to remain intact. This study…

  6. Assets and Barriers to Finding Employment

    ERIC Educational Resources Information Center

    Stolte, Michael

    2006-01-01

    In this intact-groups, quasi-experimental study, 115 unemployed job seekers who utilized federally funded labour market interventions were compared on program usage (long- or short-term), personality, personal meaning, employability skills, job search length, and pain and suffering. Results did not find significant differences in program usage or…

  7. Fermat's Technique of Finding Areas under Curves

    ERIC Educational Resources Information Center

    Staples, Ed

    2004-01-01

    Perhaps next time teachers head towards the fundamental theorem of calculus in their classroom, they may wish to consider Fermat's technique of finding expressions for areas under curves, beautifully outlined in Boyer's History of Mathematics. Pierre de Fermat (1601-1665) developed some important results in the journey toward the discovery of the…

  8. Independent Study Looks beyond Rhetoric, Finds Gains.

    ERIC Educational Resources Information Center

    Penning, Nick

    1991-01-01

    Last July, the New Initiatives Division of Sandia National Laboratory, a nuclear research center in Albuquerque, New Mexico, presented its findings on U.S. education to the U.S. Subcommittee on Elementary, Secondary, and Vocational Education. Current dropout rates, test scores, college attendance, educational expenditures, educator status, work…

  9. 77 FR 22320 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-13

    ... obtained from Rhesus monkey embryonic stem cells (ECS) into a strain of rats (RCS) that develops retinal... HUMAN SERVICES Office of the Secretary Findings of Research Misconduct AGENCY: Office of the Secretary, HHS. ACTION: Notice. SUMMARY: Notice is hereby given that the Office of Research Integrity (ORI)...

  10. Curiosity Finds Calcium-Rich Deposits

    NASA Video Gallery

    NASA’s Curiosity rover finds calcium deposits on Mars similar to thoseseen on Earth when water circulates in cracks and rock fractures.Credit: NASA/JPL-Caltech    › Curiosity's mission site

  11. Find Your Voice: Eliminate Classroom Phobias

    ERIC Educational Resources Information Center

    Miranda, Michael V.

    2007-01-01

    The academically underprepared community college student may also be psychosocially underprepared for college, a condition contributing to the development of classroom-specific social phobia and to the high attrition rate at community colleges. The "Find Your Voice Program" uses individual and group cognitive-behavioral techniques to develop…

  12. Finding Strategic Solutions to Reduce Truancy

    ERIC Educational Resources Information Center

    Reid, Ken

    2010-01-01

    This article focuses on recent developments to find strategic solutions to the problem of truancy. It considers issues related to defining truancy and why reducing truancy matters before considering what causes truancy. The article concentrates upon seven areas where further work is needed: the role of parents (and carers); early intervention,…

  13. Finding Green in the Green Movement.

    ERIC Educational Resources Information Center

    Miller, Julie A.

    1997-01-01

    Looks at the history of the environmental industry since 1970. Suggests that, although job growth is not as high as it was, the growth rate is now about 2% and those with proper training can find opportunities in environmental fields. (JOW)

  14. 78 FR 8148 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-05

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Office of the Secretary Findings of Research Misconduct AGENCY: Office of the Secretary... fellow, Department of Dermatology, Case Western Reserve University (CWRU), engaged in research...

  15. 78 FR 47699 - Findings of Research Misconduct

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-06

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Office of the Secretary Findings of Research Misconduct AGENCY: Office of the Secretary..., Department of Dermatology, Case Western Reserve University (CWRU), engaged in research misconduct in...

  16. 10 CFR 800.201 - Findings.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Findings. 800.201 Section 800.201 Energy DEPARTMENT OF ENERGY LOANS FOR BID OR PROPOSAL PREPARATION BY MINORITY BUSINESS ENTERPRISES SEEKING DOE CONTRACTS AND... minority business enterprise. (b) That the loan will assist the enterprise to participate in the...

  17. 10 CFR 800.201 - Findings.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Findings. 800.201 Section 800.201 Energy DEPARTMENT OF ENERGY LOANS FOR BID OR PROPOSAL PREPARATION BY MINORITY BUSINESS ENTERPRISES SEEKING DOE CONTRACTS AND... minority business enterprise. (b) That the loan will assist the enterprise to participate in the...

  18. 10 CFR 800.201 - Findings.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Findings. 800.201 Section 800.201 Energy DEPARTMENT OF ENERGY LOANS FOR BID OR PROPOSAL PREPARATION BY MINORITY BUSINESS ENTERPRISES SEEKING DOE CONTRACTS AND... minority business enterprise. (b) That the loan will assist the enterprise to participate in the...

  19. 10 CFR 800.201 - Findings.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Findings. 800.201 Section 800.201 Energy DEPARTMENT OF ENERGY LOANS FOR BID OR PROPOSAL PREPARATION BY MINORITY BUSINESS ENTERPRISES SEEKING DOE CONTRACTS AND... minority business enterprise. (b) That the loan will assist the enterprise to participate in the...

  20. School Health: Findings from Evaluated Programs.

    ERIC Educational Resources Information Center

    Public Health Service (DHHS), Rockville, MD. Office of Disease Prevention and Health Promotion.

    This publication presents findings from evaluations of many school health programs from across the United States. Each program includes at least one of the following eight components of a comprehensive school health program: health education, clinical services, counseling and mental health services, school environment, school food programs,…

  1. The Pleasure of Finding Things out

    ERIC Educational Resources Information Center

    Loxley, Peter

    2005-01-01

    "The pleasure of finding things out" is a collection of short works by the Nobel Prize winning scientist Richard Feynman. The book provides insights into his infectious enthusiasm for science and his love of sharing ideas about the subject with anyone who wanted to listen. Feynman has been widely acknowledged as one of the greatest physicists of…

  2. Another ``Find-the-Flaw'' Test

    NASA Astrophysics Data System (ADS)

    Grimvall, Göran

    2012-12-01

    Daniel F. Styer recently discussed physics problems where several different algebraic results are presented, and the task is to identify the correct result through reasoning based on a general understanding of physics principles. Here is a related, but more general, problem. A graph with several quite disparate captions is presented (Fig. 1). The task is to find the only caption that could be correct.

  3. 16 CFR 1210.5 - Findings.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... CIGARETTE LIGHTERS Requirements for Child Resistance § 1210.5 Findings. Section 9(f) of the Consumer Product... intended for use in lighting cigarettes and other smoking materials. Lighters may be gas- or liquid-fueled... virtue of their low price and convenience, the closest available substitutes for matches....

  4. 16 CFR 1210.5 - Findings.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... CIGARETTE LIGHTERS Requirements for Child Resistance § 1210.5 Findings. Section 9(f) of the Consumer Product... intended for use in lighting cigarettes and other smoking materials. Lighters may be gas- or liquid-fueled... virtue of their low price and convenience, the closest available substitutes for matches....

  5. Re-Establishing Broca's Initial Findings

    ERIC Educational Resources Information Center

    Richardson, Jessica D.; Fillmore, Paul; Rorden, Chris; LaPointe, Leonard L.; Fridriksson, Julius

    2012-01-01

    The importance of the left inferior pre-frontal cortex (LIPC) for speech production was first popularized by Paul Broca, providing a cornerstone of behavioral neurology and laying the foundation for future research examining brain-behavior relationships. Although Broca's findings were rigorously challenged, comprehensive contradictory evidence was…

  6. Scintigraphic findings in progressive diaphyseal dysplasia

    SciTech Connect

    Lundy, M.M.; Billingsley, J.L.; Redwine, M.D.; Turnbull, G.L.; Brown, T.J.

    1982-04-01

    A 14-yr-old white male with a severe form of progressive diaphyseal dysplasia (Engelmann-Camurati disease) was referred to our institution for evaluation of splenomegaly, which is not usually associated with the disease. Our studies included bone-marrow, and liver-spleen scans. These scintigraphic findings, along with the probable cause for splenomegaly, are discussed.

  7. Scintigraphic findings in progressive diaphyseal dysplasia

    SciTech Connect

    Lundy, M.M.; Billingsley, M.L.; Redwine, M.D.; Turnbull, G.L.; Brown, T.J.

    1982-04-01

    A 14-yr-old white male with a severe form of progressive diaphyseal dysplasia (Engelmann-Camurati disease) was referred to our institution for evaluation of splenomegaly, which is not usually associated with the disease. Our studies included Tc-99m bone, bone-marrow, and liver-spleen scans. These scintigraphic findings, along with the probable cause for splenomegaly, are discussed.

  8. Land and people: finding a balance

    USGS Publications Warehouse

    ,

    1998-01-01

    Land and People: Finding a Balance is an environmental study project that engages high school students in studying earth science resource issues. The project focuses on the interaction between people and the environment in three regions of the United States: Cape Cod, Los Angeles, and the Everglades. Each section of this project is devoted to one of the three regions.

  9. 49 CFR 831.14 - Proposed findings.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Transportation Other Regulations Relating to Transportation (Continued) NATIONAL TRANSPORTATION SAFETY BOARD... accident or incident under investigation may submit to the Board written proposed findings to be drawn from... considered, these submissions must be received before the matter is calendared for consideration at a...

  10. Computed tomographic findings in penetrating peptic ulcer

    SciTech Connect

    Madrazo, B.L.; Halpert, R.D.; Sandler, M.A.; Pearlberg, J.L.

    1984-12-01

    Four cases of peptic ulcer penetrating the head of the pancreas were diagnosed by computed tomography (CT). Findings common to 3 cases included (a) an ulcer crater, (b) a sinus tract, and (c) enlargement of the head of the pancreas. Unlike other modalities, the inherent spatial resolution of CT allows a convenient diagnosis of this important complication of peptic ulcer disease.

  11. Fact-Finding Prolongs Labor Disputes.

    ERIC Educational Resources Information Center

    Lieberman, Myron

    1979-01-01

    Fact finders should be called on the scene only when an impasse results in a disagreement over facts. Nevertheless, mediators typically recommend fact-finding regardless of the nature of the impasse. Such a move typically exacerbates the controversy instead of settling it. (Author/IRT)

  12. Granuloma faciale: An unusual diascopic finding

    PubMed Central

    Ravikiran, Shilpashree P.; Jaiswal, Ashok Kumar; Syrti, Clarify; Madan Mohan, NT; Aradhya, Sujala S.

    2016-01-01

    Granuloma faciale (GF) is a benign, chronic inflammatory disorder, characterized by reddish brown plaques with prominent follicular orificesand telangeictasia, usually occurring over the face. The condition often presents a problem in differential diagnosis. Herein we describe a case of GF with an unusual diascopic finding of an apple jelly appearance on diascopy. PMID:27294051

  13. 7 CFR 1794.43 - Agency finding.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 12 2013-01-01 2013-01-01 false Agency finding. 1794.43 Section 1794.43 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE... quality of the human environment, RUS will prepare a FONSI. Upon authorization of RUS, the applicant...

  14. 7 CFR 1794.43 - Agency finding.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 12 2011-01-01 2011-01-01 false Agency finding. 1794.43 Section 1794.43 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE... quality of the human environment, RUS will prepare a FONSI. Upon authorization of RUS, the applicant...

  15. 7 CFR 1794.43 - Agency finding.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 12 2014-01-01 2013-01-01 true Agency finding. 1794.43 Section 1794.43 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE... quality of the human environment, RUS will prepare a FONSI. Upon authorization of RUS, the applicant...

  16. Preliminary Findings on Rural Homelessness in Ohio.

    ERIC Educational Resources Information Center

    First, Richard J.; And Others

    This report is designed to present preliminary findings from the first comprehensive study of rural homelessness in the United States. The study was conducted during the first 6 months of 1990, and data were collected from interviews with 921 homeless adults in 21 randomly selected rural counties in Ohio. The sample counties represent 26% of the…

  17. Aetiology of Autism: Findings and Questions

    ERIC Educational Resources Information Center

    Rutter, M.

    2005-01-01

    Background Although there is good evidence that autism is a multifactorial disorder, an adequate understanding of the genetic and non-genetic causes has yet to be achieved. Methods Empirical research findings and conceptual reviews are reviewed with respect to evidence on possible causal influences. Results Much the strongest evidence concerns the…

  18. Changing Concepts and Findings on Autism

    ERIC Educational Resources Information Center

    Rutter, Michael

    2013-01-01

    New research findings provide major challenges regarding our understanding of the concept of autism. These are critically discussed in relation to research relevant to classification, genetics, environmental risk factors, gene-environment interplay, animal models, biomarkers, clinical features, neuropathology, pharmacotherapy, behavioral…

  19. 18 CFR 4.25 - Findings.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Findings. 4.25 Section 4.25 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT LICENSES, PERMITS, EXEMPTIONS, AND DETERMINATION...

  20. 18 CFR 4.7 - Findings.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Findings. 4.7 Section 4.7 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT LICENSES, PERMITS, EXEMPTIONS, AND DETERMINATION...

  1. Helping Students Find a Sense of Purpose

    ERIC Educational Resources Information Center

    Tully, Susan

    2009-01-01

    William Damon, a professor of education at Stanford University, has long advocated "character education" as a key component of school reform. The author of several books on the subject, his latest is "The Path to Purpose: Helping Our Children Find Their Calling in Life". In this article, the author presents an interview with Damon. He discusses…

  2. Finding the Genesis for a Thesis

    ERIC Educational Resources Information Center

    Caroll, Joyce Armstrong

    2013-01-01

    This article describes a prewriting heuristics strategy that can help students find the genesis of their thesis. The 3 functions of the heuristic procedure are that it aids in retrieving relevant information stored in the mind; draws attention to important information that can be further researched or accessed; and prepares the mind for the…

  3. African Trypanosomes Find a Fat Haven

    PubMed Central

    Beverley, Stephen M.

    2016-01-01

    The African trypanosome was thought to primarily develop in the bloodstream and interstitial spaces of its mammalian host. In this issue of Cell Host & Microbe, Trindade et al. (2016) report the surprising finding that during ongoing persistent infections in mice, a major fraction of the parasites reside within fatty tissues. PMID:27281564

  4. 38 CFR 41.510 - Audit findings.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... findings and questioned costs: (1) Reportable conditions in internal control over major programs. The... program or an audit objective identified in the compliance supplement. The auditor shall identify... type of compliance requirement for a major program or an audit objective identified in the...

  5. Reading Research: Notable Findings and Urgent Needs.

    ERIC Educational Resources Information Center

    Smith, Nila Banton

    This paper discusses some of the findings and needs of reading research. The areas of research study mentioned include word boundaries, letter names, preschool reading, teacher questioning, critical reading and Negro dialects. Researchers cited include Dolores Durkin, Frank Guszak, Jay Samuels, Guy Bond, A. Sterl Artley, Edward Fry, and Robert…

  6. Hybrid thermoelectric piezoelectric generator

    NASA Astrophysics Data System (ADS)

    Montgomery, D. S.; Hewitt, C. A.; Carroll, D. L.

    2016-06-01

    This work presents an integration of flexible thermoelectric and piezoelectric materials into a single device structure. This device architecture overcomes several prohibitive issues facing the combination of traditional thermoelectric and piezoelectric generators, while optimizing performance of the combined power output. The structure design uses a carbon nanotube/polymer thin film as a flexible thermoelectric generator that doubles as an electrode on a piezoelectric generator made of poly(vinylidene fluoride). An example 2 × 2 array of devices is shown to generate 89% of the maximum thermoelectric power, and provide 5.3 times more piezoelectric voltage when compared with a traditional device.

  7. Thermophotovoltaic energy generation

    DOEpatents

    Celanovic, Ivan; Chan, Walker; Bermel, Peter; Yeng, Adrian Y. X.; Marton, Christopher; Ghebrebrhan, Michael; Araghchini, Mohammad; Jensen, Klavs F.; Soljacic, Marin; Joannopoulos, John D.; Johnson, Steven G.; Pilawa-Podgurski, Robert; Fisher, Peter

    2015-08-25

    Inventive systems and methods for the generation of energy using thermophotovoltaic cells are described. Also described are systems and methods for selectively emitting electromagnetic radiation from an emitter for use in thermophotovoltaic energy generation systems. In at least some of the inventive energy generation systems and methods, a voltage applied to the thermophotovoltaic cell (e.g., to enhance the power produced by the cell) can be adjusted to enhance system performance. Certain embodiments of the systems and methods described herein can be used to generate energy relatively efficiently.

  8. Apollo - A pioneering generation

    NASA Technical Reports Server (NTRS)

    Fries, S. D.

    1986-01-01

    This paper describes an ongoing study of the National Aeronautics and Space Administration's (NASA's) first generation of engineers - the generation which accomplished the United States' first major achievements in manned space exploration. Combining statistical analysis with personal interviews, the study explores questions such as the origins, motivations, and career histories of NASA's first generation of engineers; that generation's role in NASA's current leadership; the relationships of science, engineering, and management in NASA's institutional culture; and changes experienced within NASA during and after the Apollo program.

  9. Innovative revenue generation.

    PubMed

    Pink, G H; Deber, R B; Lavoie, J N; Aserlind, E

    1991-01-01

    Innovative revenue generation by Canadian hospitals is drawing increasing attention. After a critical examination of the literature, we classified these into six areas: clinical/diagnostic insured services, clinical/diagnostic non-insured services, hotel services, retail services, administrative services and financial activities. We concluded that many Canadian hospitals are engaging in innovative revenue generation activities, the success of such activities has been mixed, there are many factors to consider when selecting revenue generation activities, many aspects of innovative revenue generation involve sophisticated business and risk management skills not traditionally required in hospital management, and implementation of many such activities requires support from the hospital board, hospital staff and medical staff.

  10. NEGATIVE GATE GENERATOR

    DOEpatents

    Jones, C.S.; Eaton, T.E.

    1958-02-01

    This patent relates to pulse generating circuits and more particularly to rectangular pulse generators. The pulse generator of the present invention incorporates thyratrons as switching elements to discharge a first capacitor through a load resistor to initiate and provide the body of a Pulse, and subsequently dlscharge a second capacitor to impress the potential of its charge, with opposite potential polarity across the load resistor to terminate the pulse. Accurate rectangular pulses in the millimicrosecond range are produced across a low impedance by this generator.

  11. STEAM GENERATOR GROUP PROJECT

    SciTech Connect

    Clark, R. A.; Lewis, M

    1985-09-01

    This report is a summary of progress in the Surry Steam Generator Group Project for 1984. Information is presented on the analysis of two baseline eddy current inspections of the generator. Round robin series of tests using standard in-service inspection techniques are described along with some preliminary results. Observations are reported of degradation found on tubing specimens removed from the generator, and on support plates characterized in-situ. Residual stresses measured on a tubing specimen are reported. Two steam generator repair demonstrations are described; one for antivibration bar replacement, and one on tube repair methods. Chemical analyses are shown for sludge samples removed from above the tube sheet.

  12. Electromechanically generating electricity with a gapped-graphene electric generator

    NASA Astrophysics Data System (ADS)

    Dressen, Donald; Golovchenko, Jene

    2015-03-01

    We demonstrate the fabrication and operation of a gapped-graphene electric generator (G-GEG) device. The G-GEG generates electricity from the mechanical oscillation of droplets of electrolytes and ionic liquids. The spontaneous adsorption of ionic species on graphene charges opposing electric double-layer capacitors (EDLCs) on each half of the device. Modulating the area of contact between the droplet and graphene leads to adsorption/desorption of ions, effectively charging/discharging each EDLC and generating a current. The flow of current supports a potential difference across the G-GEG due to the device's internal impedance. Both the magnitude and polarity of the induced current and voltage show a strong dependence on the type of ionic species used, suggesting that certain ions interact more strongly with graphene than others. We find that a simple model circuit consisting of an AC current source in series with a resistor and a time-varying capacitor accurately predicts the device's dynamic behavior. Additionally, we discuss the effect of graphene's intrinsic quantum capacitance on the G-GEG's performance and speculate on the utility of the device in the context of energy harvesting.

  13. Age at intracranial aneurysm rupture among generations

    PubMed Central

    Woo, D; Hornung, R; Sauerbeck, L; Brown, R; Meissner, I; Huston, J; Foroud, T; Broderick, J

    2009-01-01

    Background: Previous studies have reported intracranial aneurysm (IA) occurring at young ages in subsequent generations. These studies did not correct for duration of follow-up. Second-generation members who would have their ruptured IA late in life may not be detected due to shorter follow-up time than the first generation. We examined families in which ruptured IA occurred in two consecutive generations for the hypothesis that the second generation (F1) was more likely to have a rupture at a younger age than the older generation (F0). Methods: The Familial Intracranial Aneurysm (FIA) Study is a multicenter, international study recruiting families of ruptured and unruptured IA. All available family members are interviewed. Cox proportional hazards regression models and Kaplan-Meier curves were used to examine differences by generation. Results: Although we found that the F1 generation was more likely to have an aneurysm rupture at a younger age than the F0 generation, we found that this was largely because of a lack of follow-up time in the F1 generation. The F1 generation had 50% the rupture rate of the prior generation. When analyzed by Kaplan-Meier curves, we found a tendency to have a slightly later rupture rate in the F1 generation once time to follow-up was included in the analysis model. Conclusions: Families of ruptured intracranial aneurysm (IA) do not appear to demonstrate “anticipation.” Our finding suggests that genetic epidemiology of ruptured IA should examine all types of variations such as single base-pair changes, deletions, insertions, and other variations that do not demonstrate anticipation. GLOSSARY FIA = familial intracranial aneurysm; IA = intracranial aneurysm; SAH = subarachnoid hemorrhage. PMID:19237697

  14. Finding gold in the supply chain.

    PubMed

    Caudle, Allen

    2009-12-01

    To optimize supply chain performance and achieve savings that enhance the bottom line, hospitals should: Generate purchase orders for every item purchased. Ensure the organization is protected from undue vendor influence. Keep track of where supply chain dollars are going. Review contracts regularly to ensure competitiveness. Have a contract for each product category. Buy only what the organization is sure to use. Get rid of excess inventory. Develop a strategic plan for continued supply chain savings. PMID:20027875

  15. Finding new facts; thinking new thoughts.

    PubMed

    Schulz, Laura

    2012-01-01

    The idea of the child as an active learner is one of Piaget's enduring legacies. In this chapter, I discuss the ways in which contemporary computational models of learning do, and do not, address learning as an active, child-driven process. In Part 1, I discuss the problem of search and exploration. In Part 2, I discuss the (harder and more interesting) problem of hypothesis generation. I conclude by proposing some possible new directions for research.

  16. An experimental evaluation of endmember generation algorithms

    NASA Astrophysics Data System (ADS)

    Plaza, Antonio; Sánchez-Testal, Juan J.; Plaza, Javier; Valencia, David

    2005-11-01

    Hyperspectral imagery is a new class of image data which is mainly used in remote sensing. It is characterized by a wealth of spatial and spectral information that can be used to improve detection and estimation accuracy in chemical and biological standoff detection applications. Finding spectral endmembers is a very important task in hyperspectral data exploitation. Over the last decade, several algorithms have been proposed to find spectral endmembers in hyperspectral data. Existing algorithms may be categorized into two different classes: 1) endmember extraction algorithms (EEAs), designed to find pure (or purest available) pixels, and 2) endmember generation algorithms (EGAs), designed to find pure spectral signatures. Such a distinction between an EEA and an EGA has never been made before in the literature. In this paper, we explore the concept of endmember generation as opposed to that of endmember extraction by describing our experience with two EGAs: the optical real-time adaptative spectral identification system (ORASIS), which generates endmembers based on spectral criteria, and the automated morphological endmember extraction (AMEE), which generates endmembers based on spatial/spectral criteria. The performance of these two algoriths is compared to that achieved by two standard algorithms which can perform both as EEAs and EGAs, i.e., the pixel purity index (PPI) and the iterative error analysis (IEA). Both the PPI and IEA may also be used to generate new signatures from existing pixel vectors in the input data, as opposed to the ORASIS method, which generates new spectra using an minimum volume transform. A standard algorithm which behaves as an EEA, i.e., the N-FINDR, is also used in the comparison for demonstration purposes. Experimental results provide several intriguing findings that may help hyperspectral data analysts in selection of algorithms for specific applications.

  17. Modular Stirling Radioisotope Generator

    NASA Technical Reports Server (NTRS)

    Schmitz, Paul C.; Mason, Lee S.; Schifer, Nicholas A.

    2015-01-01

    High efficiency radioisotope power generators will play an important role in future NASA space exploration missions. Stirling Radioisotope Generators (SRG) have been identified as a candidate generator technology capable of providing mission designers with an efficient, high specific power electrical generator. SRGs high conversion efficiency has the potential to extend the limited Pu-238 supply when compared with current Radioisotope Thermoelectric Generators (RTG). Due to budgetary constraints, the Advanced Stirling Radioisotope Generator (ASRG) was canceled in the fall of 2013. Over the past year a joint study by NASA and DOE called the Nuclear Power Assessment Study (NPAS) recommended that Stirling technologies continue to be explored. During the mission studies of the NPAS, spare SRGs were sometimes required to meet mission power system reliability requirements. This led to an additional mass penalty and increased isotope consumption levied on certain SRG-based missions. In an attempt to remove the spare power system, a new generator architecture is considered which could increase the reliability of a Stirling generator and provide a more fault-tolerant power system. This new generator called the Modular Stirling Radioisotope Generator (MSRG) employs multiple parallel Stirling convertor/controller strings, all of which share the heat from the General Purpose Heat Source (GPHS) modules. For this design, generators utilizing one to eight GPHS modules were analyzed, which provide about 50 to 450 watts DC to the spacecraft, respectively. Four Stirling convertors are arranged around each GPHS module resulting in from 4 to 32 Stirling/controller strings. The convertors are balanced either individually or in pairs, and are radiatively coupled to the GPHS modules. Heat is rejected through the housing/radiator which is similar in construction to the ASRG. Mass and power analysis for these systems indicate that specific power may be slightly lower than the ASRG and

  18. Arbitrary waveform generator

    NASA Astrophysics Data System (ADS)

    Blackmon, Fletcher A.

    1992-04-01

    It is a general purpose and object of the present invention to provide an arbitrary waveform generator. It is a further object that the generator has the ability to produce both pulse waveforms and continuous waveforms. Other objects are that the generator be compact and only require low power for lending itself to battery powered operation. These objects are accomplished with the present invention by providing a system in which digital waveforms are created using a software package such as DADiSP. The software package forms signals that are then transferred to an EPROM. Each signal type occupies a certain block of address space within the EPROM. A great number of signals may be digitally stored in this way. The operator then constructs simple microprocessor computer codes to access any signal, any combination of signals, or all signals to form a unique waveform generation sequence. Therefore the operator selects arbitrarily which of the previously stored signals to generate. Key features include the EPROM storing a single pulse for pulse waveforms and a single period of waveform for continuous waveforms. Other key features are the ability to control the sequence of generation, the number of times each signal is generated, the time between pulses, and the time between the generation of different signal types. These features are controlled by the microprocessor codes residing in a microprocessor.

  19. The fifth generation computer

    SciTech Connect

    Moto-Oka, T.; Kitsuregawa, M.

    1985-01-01

    The leader of Japan's Fifth Generation computer project, known as the 'Apollo' project, and a young computer scientist elucidate in this book the process of how the idea came about, international reactions, the basic technology, prospects for realization, and the abilities of the Fifth Generation computer. Topics considered included forecasting, research programs, planning, and technology impacts.

  20. Generation Y Perspectives

    NASA Technical Reports Server (NTRS)

    Skytland, Nicholas; Painting, Kristen; Barrera, Aaron; Fitzpatrick, Garret

    2008-01-01

    This viewgraph presentation reviews the perception of NASA and the importance of engaging those people born between 1977 and 2000, also known as Generation Y. It examines some of the differences in attitudes and experiences, and how it reflects on how they view NASA. It also discusses use of the internet in connecting to the people from that generation.

  1. Hospitality services generate revenue.

    PubMed

    Bizouati, S

    1993-01-01

    An increasing number of hospitals are undertaking external revenue-generating activities to supplement their shrinking budgets. Written at the request of Leadership, this article outlines an example of a successful catering service -- a money-generating business that more Canadian hospitals could profitably consider.

  2. Managing Generational Diversity

    ERIC Educational Resources Information Center

    O'Donovan, Eamonn

    2009-01-01

    Many school leaders have explored the issue of diversity when it comes to students, teachers and staff. Their focus typically has been on gender and ethnicity. However, generational diversity, an area of diversity that warrants serious consideration, has received less attention. Generational intelligence is important today for two reasons. First…

  3. The Next Great Generation?

    ERIC Educational Resources Information Center

    Brownstein, Andrew

    2000-01-01

    Discusses ideas from a new book, "Millennials Rising: The Next Great Generation," (by Neil Howe and William Strauss) suggesting that youth culture is on the cusp of a radical shift with the generation beginning with this year's college freshmen who are typically team oriented, optimistic, and poised for greatness on a global scale. Includes a…

  4. Geometric grid generation

    NASA Technical Reports Server (NTRS)

    Ives, David

    1995-01-01

    This paper presents a highly automated hexahedral grid generator based on extensive geometrical and solid modeling operations developed in response to a vision of a designer-driven one day turnaround CFD process which implies a designer-driven one hour grid generation process.

  5. Internal split field generator

    DOEpatents

    Thundat; ,Thomas George; Van Neste, Charles W.; Vass, Arpad Alexander

    2012-01-03

    A generator includes a coil of conductive material. A stationary magnetic field source applies a stationary magnetic field to the coil. An internal magnetic field source is disposed within a cavity of the coil to apply a moving magnetic field to the coil. The stationary magnetic field interacts with the moving magnetic field to generate an electrical energy in the coil.

  6. Cross-Generational Storytelling

    ERIC Educational Resources Information Center

    Smith, Cindy; Thurston, Judy Kay

    2007-01-01

    What happens when you combine senior citizens, pre-service art teachers, and elementary students? Cross-generational connections based on sharing memories, ideas, skills, laughter, tears, and creativity. The authors describe the cross-generational book exchange project. This project was initiated when a group of Central Michigan University (CMU)…

  7. Automatic finite element generators

    NASA Technical Reports Server (NTRS)

    Wang, P. S.

    1984-01-01

    The design and implementation of a software system for generating finite elements and related computations are described. Exact symbolic computational techniques are employed to derive strain-displacement matrices and element stiffness matrices. Methods for dealing with the excessive growth of symbolic expressions are discussed. Automatic FORTRAN code generation is described with emphasis on improving the efficiency of the resultant code.

  8. Generative Processes: Thick Drawing

    ERIC Educational Resources Information Center

    Wallick, Karl

    2012-01-01

    This article presents techniques and theories of generative drawing as a means for developing complex content in architecture design studios. Appending the word "generative" to drawing adds specificity to the most common representation tool and clarifies that such drawings are not singularly about communication or documentation but are also…

  9. Generativity and Flourishing

    ERIC Educational Resources Information Center

    Snow, Nancy

    2015-01-01

    The psychological construct of "generativity" was introduced by Erik Erikson in "Childhood and Society" in 1950. This rich and complex notion encompasses the constellation of desires, concerns and commitments that motivate individuals and societies to pass on legacies to future generations. "Flourishing," which means,…

  10. When Generations Collide

    ERIC Educational Resources Information Center

    Fogg, Piper

    2009-01-01

    As members of Generations X and Y face a workplace dominated by boomers, they are all starting to chafe. Some colleges are having trouble attracting, managing, and sometimes retaining people younger than 35. Members of the younger generations grew up watching their parents sacrifice for their careers, and they want something different: balance and…

  11. When Generations Collide

    ERIC Educational Resources Information Center

    Fogg, Piper

    2008-01-01

    When four generations converge in the academic workplace, it can create serious culture clashes. It is happening across college campuses--in offices as diverse as admissions, student affairs, legal affairs, and technology. It is especially striking in the faculty ranks, where generational challenges have extra significance amid recruiting efforts,…

  12. Improved solid aerosol generator

    DOEpatents

    Prescott, D.S.; Schober, R.K.; Beller, J.

    1988-07-19

    An improved solid aerosol generator used to produce a gas borne stream of dry, solid particles of predetermined size and concentration. The improved solid aerosol generator nebulizes a feed solution of known concentration with a flow of preheated gas and dries the resultant wet heated aerosol in a grounded, conical heating chamber, achieving high recovery and flow rates. 2 figs.

  13. Solid aerosol generator

    DOEpatents

    Prescott, Donald S.; Schober, Robert K.; Beller, John

    1992-01-01

    An improved solid aerosol generator used to produce a gas borne stream of dry, solid particles of predetermined size and concentration. The improved solid aerosol generator nebulizes a feed solution of known concentration with a flow of preheated gas and dries the resultant wet heated aerosol in a grounded, conical heating chamber, achieving high recovery and flow rates.

  14. Solid aerosol generator

    DOEpatents

    Prescott, D.S.; Schober, R.K.; Beller, J.

    1992-03-17

    An improved solid aerosol generator used to produce a gas borne stream of dry, solid particles of predetermined size and concentration is disclosed. The improved solid aerosol generator nebulizes a feed solution of known concentration with a flow of preheated gas and dries the resultant wet heated aerosol in a grounded, conical heating chamber, achieving high recovery and flow rates. 2 figs.

  15. Hospitality services generate revenue.

    PubMed

    Bizouati, S

    1993-01-01

    An increasing number of hospitals are undertaking external revenue-generating activities to supplement their shrinking budgets. Written at the request of Leadership, this article outlines an example of a successful catering service -- a money-generating business that more Canadian hospitals could profitably consider. PMID:10127850

  16. Next generation space robot

    NASA Technical Reports Server (NTRS)

    Iwata, Tsutomu; Oda, Mitsushige; Imai, Ryoichi

    1989-01-01

    The recent research effort on the next generation space robots is presented. The goals of this research are to develop the fundamental technologies and to acquire the design parameters of the next generation space robot. Visual sensing and perception, dexterous manipulation, man machine interface and artificial intelligence techniques such as task planning are identified as the key technologies.

  17. Primary intracranial choriocarcinoma: MR imaging findings.

    PubMed

    Lv, X-F; Qiu, Y-W; Zhang, X-L; Han, L-J; Qiu, S-J; Xiong, W; Wen, G; Zhang, Y-Z; Zhang, J

    2010-11-01

    PICCC is the rarest, most malignant primary intracranial GCT. The purpose of this study was to describe and characterize the MR imaging findings in a series of 7 patients (6 males and 1 female; mean age, 11.9 years) with pathologically proved PICCC in our institution from 2004 to 2009. All tumors were located within the pineal (n = 6) or suprasellar (n = 1) regions. On T2-weighted MR imaging, the lesions appeared markedly heterogeneous with areas of both hypointensity and hyperintensity reflecting the histologic heterogeneity, including hemorrhage, fibrosis, cysts, or necrosis. Heterogeneous (n = 7), ringlike (n = 4), and/or intratumoral nodular (n = 3) enhancement was noted on T1-weighted images with gadolinium. These MR imaging findings, combined with patient age and serum β-HCG levels, may prove helpful in distinguishing PICCC from the more common primary brain tumors, thereby avoiding biopsy of this highly vascular tumor. PMID:20616180

  18. Histological findings after brown recluse spider envenomation.

    PubMed

    Elston, D M; Eggers, J S; Schmidt, W E; Storrow, A B; Doe, R H; McGlasson, D; Fischer, J R

    2000-06-01

    Histologic specimens from 41 rabbits were studied for changes resulting from the manual injection of brown recluse spider venom. Major findings included a mixed inflammatory cell infiltrate, coagulative tissue necrosis, and vasculitis. All specimens demonstrated a well-delineated zone of eosinophilic staining recognizable as "mummified" coagulative necrosis of the epidermis and dermis. A dense band of neutrophils bordered the zone of necrosis. Immediately adjacent to the neutrophilic band, small vessel vasculitis was a universal finding. Degranulated eosinophils and neutrophils and macrophages filled with eosinophilic granules were common. Inflammatory foci were often centered on groups of lipocytes within the dermis. Large vessel vasculitis resembling that seen in polyarteritis nodosa was present deep to 7 of the 40 eschars. Large vessel vasculitis may contribute to the large zones of necrosis seen after some brown recluse spider bites. Eosinophils may play a role in tissue damage after envenomation.

  19. Interferometric direction finding with a metamaterial detector

    SciTech Connect

    Venkatesh, Suresh; Schurig, David; Shrekenhamer, David; Padilla, Willie; Xu, Wangren; Sonkusale, Sameer

    2013-12-16

    We present measurements and analysis demonstrating useful direction finding of sources in the S band (2–4 GHz) using a metamaterial detector. An augmented metamaterial absorber that supports magnitude and phase measurement of the incident electric field, within each unit cell, is described. The metamaterial is implemented in a commercial printed circuit board process with off-board back-end electronics. We also discuss on-board back-end implementation strategies. Direction finding performance is analyzed for the fabricated metamaterial detector using simulated data and the standard algorithm, MUtiple SIgnal Classification. The performance of this complete system is characterized by its angular resolution as a function of radiation density at the detector. Sources with power outputs typical of mobile communication devices can be resolved at kilometer distances with sub-degree resolution and high frame rates.

  20. Island-finding ability of marine turtles.

    PubMed Central

    Hays, Graeme C; Akesson, Susanne; Broderick, Annette C; Glen, Fiona; Godley, Brendan J; Papi, Floriano; Luschi, Paolo

    2003-01-01

    Green turtles (Chelonia mydas) swim from foraging grounds along the Brazilian coast to Ascension Island to nest, over 2200 km distant in the middle of the equatorial Atlantic. To test the hypothesis that turtles use wind-borne cues to locate Ascension Island we found turtles that had just completed nesting and then moved three individuals 50 km northwest (downwind) of the island and three individuals 50 km southeast (upwind). Their subsequent movements were tracked by satellite. Turtles released downwind returned to Ascension Island within 1, 2 and 4 days, respectively. By contrast, those released upwind had far more difficulty in relocating Ascension Island, two eventually returning after 10 and 27 days and the third heading back to Brazil after failing to find its way back to the island. These findings strongly support the hypothesis that wind-borne cues are used by turtles to locate Ascension Island. PMID:12952621