KSC-2014-3247

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- Apollo astronauts and their families examine the mission plaques mounted on the wall in the lobby of the Launch Control Center at NASA's Kennedy Space Center in Florida. The facility houses the firing rooms from which the Apollo countdowns were conducted. Kennedy Director Robert Cabana, at left, led the tour which followed a ceremony renaming the refurbished Operations and Checkout Building for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. The ceremony was part of NASA's 45th anniversary celebration of the Apollo 11 moon landing. As the world watched, Neil Armstrong and Buzz Aldrin landed in the moon's Sea of Tranquility on July 20, 1969, aboard the lunar module Eagle. Meanwhile, crewmate Michael Collins orbited above in the command module Columbia. For more, visit http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission. Photo credit: NASA/Kim Shiflett

KSC-2014-3246

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- Kennedy Space Center Director Robert Cabana, a former space shuttle astronaut, at front right, finds a moment to talk to Apollo astronaut Jim Lovell during a tour for Apollo astronauts and their families of the Vehicle Assembly Building, the facility in which Apollo's Saturn V rockets were processed at NASA's Kennedy Space Center in Florida. The visit followed a ceremony renaming Kennedy's refurbished Operations and Checkout Building for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. The ceremony was part of NASA's 45th anniversary celebration of the Apollo 11 moon landing. As the world watched, Neil Armstrong and Buzz Aldrin landed in the moon's Sea of Tranquility on July 20, 1969, aboard the lunar module Eagle. Meanwhile, crewmate Michael Collins orbited above in the command module Columbia. For more, visit http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission. Photo credit: NASA/Kim Shiflett

KSC-69PC-484

NASA Image and Video Library

1969-07-26

KENNEDY SPACE CENTER, FLA. - Within the Mobile Quarantine Facility, Apollo 11 astronauts (left to right) Michael Collins, Edwin E. Aldrin Jr. and Neil A. Armstrong relax following their successful lunar landing mission. They spent two-and-one-half days in the quarantine trailer enroute from the USS Hornet, prime recovery ship, to the Lunar Receiving Laboratory at the Manned Spacecraft Center in Houston. The Hornet docked at Pearl Harbor where the trailer was transferred to a jet aircraft for the flight to Houston.

KSC-2012-2488

NASA Image and Video Library

2012-04-14

CAPE CANAVERAL, Fla. -- Apollo 11 Commander Neil Armstrong addresses the audience at the 40th anniversary celebration of Apollo 16's lunar landing, which occurred April 20, 1972. The Astronaut Scholarship Foundation hosted the soiree at the Kennedy Space Center Visitor Complex's Saturn V Center. The 11-day Apollo 16 mission featured three moonwalks, including a nearly 17-mile lunar rover road trip to collect more than 200 pounds of moon rocks to return to Earth. Photo credit: NASA/Chris Chamberland

KENNEDY SPACE CENTER, FLA. - Dynamac employees (from left) Larry Burns, Debbie Wells and Neil Yorio carry boxes of hardware into the Space Life Sciences Lab (SLSL), formerly known as the Space Experiment Research and Processing Laboratory (SERPL). They are transferring equipment from Hangar L. The new lab is a state-of-the-art facility being built for ISS biotechnology research. Developed as a partnership between NASA-KSC and the State of Florida, NASA’s life sciences contractor will be the primary tenant of the facility, leasing space to conduct flight experiment processing and NASA-sponsored research. About 20 percent of the facility will be available for use by Florida’s university researchers through the Florida Space Research Institute.

NASA Image and Video Library

2003-09-10

KENNEDY SPACE CENTER, FLA. - Dynamac employees (from left) Larry Burns, Debbie Wells and Neil Yorio carry boxes of hardware into the Space Life Sciences Lab (SLSL), formerly known as the Space Experiment Research and Processing Laboratory (SERPL). They are transferring equipment from Hangar L. The new lab is a state-of-the-art facility being built for ISS biotechnology research. Developed as a partnership between NASA-KSC and the State of Florida, NASA’s life sciences contractor will be the primary tenant of the facility, leasing space to conduct flight experiment processing and NASA-sponsored research. About 20 percent of the facility will be available for use by Florida’s university researchers through the Florida Space Research Institute.

KSC-2014-3253

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- Family members of Apollo 11 astronaut Neil Armstrong sign a banner displaying the new name of the Operations and Checkout Building at NASA's Kennedy Space Center in Florida. The banner signing followed a ceremony renaming the refurbished building for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. From left are Armstrong's son Rick, his grandson Bryce and his granddaughter Lily. The building's high bay is being used to support the agency's new Orion spacecraft and is the same spaceport facility where the Apollo 11 command/service module and lunar module were prepped for the first lunar landing mission in 1969. Orion is designed to take humans farther than they’ve ever gone before, serving as the exploration vehicle that will carry astronauts to deep space and sustain the crew during travel to destinations such as an asteroid or Mars. The ceremony was part of NASA's 45th anniversary celebration of the Apollo 11 moon landing. As the world watched, Neil Armstrong and Buzz Aldrin landed in the moon's Sea of Tranquility on July 20, 1969, aboard the lunar module Eagle. Meanwhile, crewmate Michael Collins orbited above in the command module Columbia. For more, visit http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission. Photo credit: NASA/Kevin O'Connell

KSC-2015-1275

NASA Image and Video Library

2015-02-02

CAPE CANAVERAL, Fla. – In the Neil Armstrong Operations and Checkout Building high bay at NASA's Kennedy Space Center in Florida, NASA Administrator Charlie Bolden, left, and Kennedy Space Center Director Bob Cabana answer questions from the news media during NASA's televised fiscal year 2016 budget rollout event. NASA's Orion, SpaceX Dragon and Boeing CST-100 spacecraft, all destined to play a role in NASA’s overall exploration objectives, were on display. For information on NASA's budget, visit http://www.nasa.gov/budget. Photo credit: NASA/Amber Watson

KSC-99pp0937

NASA Image and Video Library

1999-07-16

KENNEDY SPACE CENTER, FLA. -- Neil Armstrong, former Apollo 11 astronaut, and first man to walk on the moon, talks about his experiences for an enthusiastic audience at the Apollo/Saturn V Center, part of the KSC Visitor Complex. The occasion was a banquet celebrating the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Among other guests at the banquet were astronauts Wally Schirra, Edwin "Buzz" Aldrin and Walt Cunningham. Gene Cernan was the last man to walk on the moon

KSC-2014-3249

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- Apollo astronauts and their families receive a briefing in one of the remodeled firing rooms in the Launch Control Center at NASA's Kennedy Space Center in Florida. The facility's firing rooms were used to conduct the Saturn V countdowns during the Apollo Program. The tour followed a ceremony renaming the refurbished Operations and Checkout Building for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. Second from left is Apollo 11 moonwalker Buzz Aldrin and former astronaut Jim Lovell, a member of the Apollo 8 and Apollo 13 crews, standing next to him, at center. The ceremony was part of NASA's 45th anniversary celebration of the Apollo 11 moon landing. As the world watched, Neil Armstrong and Buzz Aldrin landed in the moon's Sea of Tranquility on July 20, 1969, aboard the lunar module Eagle. Meanwhile, crewmate Michael Collins orbited above in the command module Columbia. For more, visit http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission. Photo credit: NASA/Kim Shiflett

KSC-2014-3245

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- Kennedy Space Center Director Robert Cabana, at right, escorts Apollo astronauts and their families through the transfer aisle of the 525-foot-tall Vehicle Assembly Building, the facility in which Apollo's Saturn V rockets were processed at NASA's Kennedy Space Center in Florida. The visit followed a ceremony renaming Kennedy's refurbished Operations and Checkout Building for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. In front of the group, from left, are Apollo 11 moonwalker Buzz Aldrin, Armstrong's son Mark, Apollo astronaut Jim Lovell, Armstrong's former wife Janet, and Cabana. The ceremony was part of NASA's 45th anniversary celebration of the Apollo 11 moon landing. As the world watched, Neil Armstrong and Buzz Aldrin landed in the moon's Sea of Tranquility on July 20, 1969, aboard the lunar module Eagle. Meanwhile, crewmate Michael Collins orbited above in the command module Columbia. For more, visit http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission. Photo credit: NASA/Kim Shiflett

KSC-2014-3248

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- Apollo astronauts and their families tour one of the remodeled firing rooms in the Launch Control Center at NASA's Kennedy Space Center in Florida. The facility's firing rooms were used to conduct the Saturn V countdowns during the Apollo Program. NASA Administrator Charles Bolden, at left, accompanied the astronauts on the tour which followed a ceremony renaming the refurbished Operations and Checkout Building for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. Former astronaut Jim Lovell, a member of the Apollo 8 and Apollo 13 crews, is at center. The ceremony was part of NASA's 45th anniversary celebration of the Apollo 11 moon landing. As the world watched, Neil Armstrong and Buzz Aldrin landed in the moon's Sea of Tranquility on July 20, 1969, aboard the lunar module Eagle. Meanwhile, crewmate Michael Collins orbited above in the command module Columbia. For more, visit http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission. Photo credit: NASA/Kim Shiflett

KSC-2014-3196

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- At the Kennedy Space Center in Florida, NASA officials and Apollo astronauts visiting Launch Pad 39B with their families and friends take a moment to enjoy the view. From left are Apollo astronaut Jim Lovell, Center Director Bob Cabana, Apollo 11 command module pilot Mike Collins, and Apollo 11 moonwalker Buzz Aldrin's son Andy Aldrin. The group is at Kennedy for a ceremony renaming the Operations and Checkout Building for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. The pad is being modified to support the agency's new Orion spacecraft which will lift off atop the Space Launch System rocket. Orion is designed to take humans farther than they’ve ever gone before, serving as the exploration vehicle that will carry astronauts to deep space and sustain the crew during travel to destinations such as an asteroid or Mars. The visit of the former astronauts was part of NASA's 45th anniversary celebration of the Apollo 11 moon landing. As the world watched, Neil Armstrong and Neil Aldrin landed in the moon's Sea of Tranquility aboard the lunar module Eagle on July 20, 1969. Meanwhile, crewmate Michael Collins orbited above in the command module Columbia. For more, visit http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission. Photo credit: NASA/Kim Shiflett

KSC-2015-1282

NASA Image and Video Library

2015-02-02

CAPE CANAVERAL, Fla. – In the Neil Armstrong Operations and Checkout Building high bay at NASA's Kennedy Space Center in Florida, NASA Administrator Charlie Bolden delivers a “state of the agency” address at NASA's televised fiscal year 2016 budget rollout event. Representatives from the Kennedy workforce, news media and social media were in attendance. NASA's Orion, SpaceX Dragon and Boeing CST-100 spacecraft, all destined to play a role in NASA’s overall exploration objectives, were on display. For information on NASA's budget, visit http://www.nasa.gov/budget. Photo credit: NASA/Amber Watson

KSC-07pd1035

NASA Image and Video Library

2007-05-05

KENNEDY SPACE CENTER, FLA. -- At the U.S. Astronaut Hall of Fame induction ceremony, Boy Scouts lead the pledge of allegiance. The May 5 induction added space shuttle commanders Michael L. Coats, Steven A. Hawley and Jeffrey A. Hoffman to the Hall of Fame. They grow the number of space explorers enshrined in the Hall of Fame to 66. These gentlemen have joined such American space heroes as Neil Armstrong, John Glenn, Alan Shepard and Sally Ride. The ceremony was held at the Kennedy Space Center's Apollo/Saturn V Center. Photo credit: NASA/Kim Shiflett

KSC-99pp0859

NASA Image and Video Library

1999-07-16

KENNEDY SPACE CENTER, FLA. -- Former Apollo astronaut Gene Cernan makes a point during a presentation at the Apollo 11 anniversary banquet honoring the Apollo team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Cernan appeared with other former astronauts Neil Armstrong, the first man to walk on the moon; Edwin "Buzz" Aldrin; Walt Cunningham; and others

KENNEDY SPACE CENTER, FLA. - Employees check out the new chamber facilities of the Space Life Sciences Lab (SLSL), formerly known as the Space Experiment Research and Processing Laboratory (SERPL). From left are Ray Wheeler, with NASA; Debbie Wells and Larry Burns, with Dynamac; A.O. Rule, president of Environmental Growth Chambers, Inc. (ECG); Neil Yorio, with Dynamac; and John Wiezchowski, with ECG. The SLSL is a state-of-the-art facility being built for ISS biotechnology research. Developed as a partnership between NASA-KSC and the State of Florida, NASA’s life sciences contractor will be the primary tenant of the facility, leasing space to conduct flight experiment processing and NASA-sponsored research. About 20 percent of the facility will be available for use by Florida’s university researchers through the Florida Space Research Institute.

NASA Image and Video Library

2003-09-10

KENNEDY SPACE CENTER, FLA. - Employees check out the new chamber facilities of the Space Life Sciences Lab (SLSL), formerly known as the Space Experiment Research and Processing Laboratory (SERPL). From left are Ray Wheeler, with NASA; Debbie Wells and Larry Burns, with Dynamac; A.O. Rule, president of Environmental Growth Chambers, Inc. (ECG); Neil Yorio, with Dynamac; and John Wiezchowski, with ECG. The SLSL is a state-of-the-art facility being built for ISS biotechnology research. Developed as a partnership between NASA-KSC and the State of Florida, NASA’s life sciences contractor will be the primary tenant of the facility, leasing space to conduct flight experiment processing and NASA-sponsored research. About 20 percent of the facility will be available for use by Florida’s university researchers through the Florida Space Research Institute.

KSC-2014-3250

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- Apollo astronauts and their families receive a briefing in one of the remodeled firing rooms in the Launch Control Center at NASA's Kennedy Space Center in Florida. The facility's firing rooms were used to conduct the Saturn V countdowns during the Apollo Program. The tour followed a ceremony renaming the refurbished Operations and Checkout Building for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. Second from left is Apollo 11 moonwalker Buzz Aldrin and former astronaut Jim Lovell, a member of the Apollo 8 and Apollo 13 crews, standing next to him, at center. The ceremony was part of NASA's 45th anniversary celebration of the Apollo 11 moon landing. As the world watched, Neil Armstrong and Buzz Aldrin landed in the moon's Sea of Tranquility on July 20, 1969, aboard the lunar module Eagle. Meanwhile, crewmate Michael Collins orbited above in the command module Columbia. For more, visit http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission. Photo credit: NASA/Kevin O'Connell

KSC-2014-3217

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- At the Kennedy Space Center in Florida, a crowd turns out for a ceremony renaming the refurbished Operations and Checkout Building for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. The building's high bay is being used to support the agency's new Orion spacecraft and is the same spaceport facility where the Apollo 11 command/service module and lunar module were prepped for the first lunar landing mission in 1969. Orion is designed to take humans farther than they’ve ever gone before, serving as the exploration vehicle that will carry astronauts to deep space and sustain the crew during travel to destinations such as an asteroid or Mars. The ceremony was part of NASA's 45th anniversary celebration of the Apollo 11 moon landing. As the world watched, Neil Armstrong and Buzz Aldrin landed in the moon's Sea of Tranquility on July 20, 1969, aboard the lunar module Eagle. Meanwhile, crewmate Michael Collins orbited above in the command module Columbia. For more, visit http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission. Photo credit: NASA/Kim Shiflett

KSC-2015-1283

NASA Image and Video Library

2015-02-02

CAPE CANAVERAL, Fla. – In the Neil Armstrong Operations and Checkout Building high bay at NASA's Kennedy Space Center in Florida, NASA Administrator Charlie Bolden delivers a “state of the agency” address at NASA's televised fiscal year 2016 budget rollout event. Kennedy Space Center Director Bob Cabana, seated, made the opening remarks. Representatives from the Kennedy workforce, news media and social media were in attendance. NASA's Orion, SpaceX Dragon and Boeing CST-100 spacecraft, all destined to play a role in NASA’s overall exploration objectives, were on display. For information on NASA's budget, visit http://www.nasa.gov/budget. Photo credit: NASA/Amber Watson

KSC-2015-1273

NASA Image and Video Library

2015-02-02

CAPE CANAVERAL, Fla. – In the Neil Armstrong Operations and Checkout Building high bay at NASA's Kennedy Space Center in Florida, NASA Administrator Charlie Bolden delivers a “state of the agency” address at NASA's televised fiscal year 2016 budget rollout event with Kennedy Space Center Director Bob Cabana looking on, at right. Representatives from the Kennedy workforce, news media and social media were in attendance. NASA's Orion, SpaceX Dragon and Boeing CST-100 spacecraft, all destined to play a role in NASA’s overall exploration objectives, were on display. For information on NASA's budget, visit http://www.nasa.gov/budget. Photo credit: NASA/Amber Watson

KSC-2015-1284

NASA Image and Video Library

2015-02-02

CAPE CANAVERAL, Fla. – In the Neil Armstrong Operations and Checkout Building high bay at NASA's Kennedy Space Center in Florida, NASA Administrator Charlie Bolden delivers a “state of the agency” address at NASA's televised fiscal year 2016 budget rollout event. Kennedy Space Center Director Bob Cabana, seated, made the opening remarks. Representatives from the Kennedy workforce, news media and social media were in attendance. NASA's Orion, SpaceX Dragon and Boeing CST-100 spacecraft, all destined to play a role in NASA’s overall exploration objectives, were on display. For information on NASA's budget, visit http://www.nasa.gov/budget. Photo credit: NASA/Amber Watson

KSC-2015-1272

NASA Image and Video Library

2015-02-02

CAPE CANAVERAL, Fla. – In the Neil Armstrong Operations and Checkout Building high bay at NASA's Kennedy Space Center in Florida, Kennedy Space Center Director Bob Cabana introduces NASA Administrator Charlie Bolden, at left, who will deliver a “state of the agency” address at NASA's televised fiscal year 2016 budget rollout event. Representatives from the Kennedy workforce, news media and social media were in attendance. NASA's Orion, SpaceX Dragon and Boeing CST-100 spacecraft, all destined to play a role in NASA’s overall exploration objectives, were on display. For information on NASA's budget, visit http://www.nasa.gov/budget. Photo credit: NASA/Amber Watson

KSC-99pp0931

NASA Image and Video Library

1999-07-16

KENNEDY SPACE CENTER, FLA. -- Former Apollo astronauts Neil Armstrong (left) and Gene Cernan entertain the audience during an anniversary banquet honoring the Apollo program team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Other guests at the banquet were astronauts Wally Schirra, Edwin "Buzz" Aldrin and Walt Cunningham. Armstrong was the first man to walk on the moon; Cernan was the last

KSC-99pp0933

NASA Image and Video Library

1999-07-16

KENNEDY SPACE CENTER, FLA. -- Former Apollo astronauts Edwin "Buzz" Aldrin (left) and Gene Cernan share stories about their missions for an audience attending an anniversary banquet honoring the Apollo program team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Other guests at the banquet were astronauts Wally Schirra, Gene Cernan and Walt Cunningham. Neil Armstrong was the first man to walk on the moon; Gene Cernan was the last

KSC-07pd1034

NASA Image and Video Library

2007-05-05

KENNEDY SPACE CENTER, FLA. -- At the Kennedy Space Center's Apollo/Saturn V Center, a wreath and poster honor former astronaut Wally Schirra, who died May 3. The site is the location for the U.S. Astronaut Hall of Fame induction ceremony. The May 5 induction added space shuttle commanders Michael L. Coats, Steven A. Hawley and Jeffrey A. Hoffman to the Hall of Fame. They grow the number of space explorers enshrined in the Hall of Fame to 66. These gentlemen have joined such American space heroes as Neil Armstrong, John Glenn, Alan Shepard and Sally Ride. Photo credit: NASA/Kim Shiflett

Abnormal Expressions of DNA Glycosylase Genes NEIL1, NEIL2, and NEIL3 Are Associated with Somatic Mutation Loads in Human Cancer.

PubMed

Shinmura, Kazuya; Kato, Hisami; Kawanishi, Yuichi; Igarashi, Hisaki; Goto, Masanori; Tao, Hong; Inoue, Yusuke; Nakamura, Satoki; Misawa, Kiyoshi; Mineta, Hiroyuki; Sugimura, Haruhiko

2016-01-01

The effects of abnormalities in the DNA glycosylases NEIL1, NEIL2, and NEIL3 on human cancer have not been fully elucidated. In this paper, we found that the median somatic total mutation loads and the median somatic single nucleotide mutation loads exhibited significant inverse correlations with the median NEIL1 and NEIL2 expression levels and a significant positive correlation with the median NEIL3 expression level using data for 13 cancer types from the Cancer Genome Atlas (TCGA) database. A subset of the cancer types exhibited reduced NEIL1 and NEIL2 expressions and elevated NEIL3 expression, and such abnormal expressions of NEIL1, NEIL2, and NEIL3 were also significantly associated with the mutation loads in cancer. As a mechanism underlying the reduced expression of NEIL1 in cancer, the epigenetic silencing of NEIL1 through promoter hypermethylation was found. Finally, we investigated the reason why an elevated NEIL3 expression level was associated with an increased number of somatic mutations in cancer and found that NEIL3 expression was positively correlated with the expression of APOBEC3B, a potent inducer of mutations, in diverse cancers. These results suggested that the abnormal expressions of NEIL1, NEIL2, and NEIL3 are involved in cancer through their association with the somatic mutation load.

KSC-2014-3200

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- At the Kennedy Space Center in Florida, visiting Apollo astronauts have a group portrait taken in front of the refurbished Operations and Checkout Building, newly named for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. From left are Mike Collins, Buzz Aldrin and Jim Lovell. The building's high bay is being used to support the agency's new Orion spacecraft, which will lift off atop the Space Launch System rocket. Orion is designed to take humans farther than they’ve ever gone before, serving as the exploration vehicle that will carry astronauts to deep space and sustain the crew during travel to destinations such as an asteroid or Mars. The visit of the former astronauts was part of NASA's 45th anniversary celebration of the Apollo 11 moon landing. As the world watched, Neil Armstrong and Aldrin landed in the moon's Sea of Tranquility aboard the lunar module Eagle on July 20, 1969. Meanwhile, crewmate Collins orbited above in the command module Columbia. For more, visit http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission. Photo credit: NASA/Kevin O'Connell

KSC-2014-3213

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- At the Kennedy Space Center in Florida, Center Director Robert Cabana addresses the audience at a ceremony renaming the refurbished Operations and Checkout Building for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. The building's high bay is being used to support the agency's new Orion spacecraft and is the same spaceport facility where the Apollo 11 command/service module and lunar module were prepped for the first lunar landing mission in 1969. Orion is designed to take humans farther than they’ve ever gone before, serving as the exploration vehicle that will carry astronauts to deep space and sustain the crew during travel to destinations such as an asteroid or Mars. The ceremony was part of NASA's 45th anniversary celebration of the Apollo 11 moon landing. As the world watched, Neil Armstrong and Buzz Aldrin landed in the moon's Sea of Tranquility on July 20, 1969, aboard the lunar module Eagle. Meanwhile, crewmate Michael Collins orbited above in the command module Columbia. For more, visit http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission. Photo credit: NASA/Kim Shiflett

KSC-2014-3205

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- At the Kennedy Space Center in Florida, Apollo 11 astronaut Michael Collins participates in a ceremony renaming the refurbished Operations and Checkout Building for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. The building's high bay is being used to support the agency's new Orion spacecraft and is the same spaceport facility where the Apollo 11 command/service module and lunar module were prepped for the first lunar landing mission in 1969. Orion is designed to take humans farther than they’ve ever gone before, serving as the exploration vehicle that will carry astronauts to deep space and sustain the crew during travel to destinations such as an asteroid or Mars. The ceremony was part of NASA's 45th anniversary celebration of the Apollo 11 moon landing. As the world watched, Neil Armstrong and Buzz Aldrin landed in the moon's Sea of Tranquility on July 20, 1969, aboard the lunar module Eagle. Meanwhile, crewmate Michael Collins orbited above in the command module Columbia. For more, visit http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission. Photo credit: NASA/Kim Shiflett

KSC-2014-3252

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- Apollo 11 command module pilot Michael Collins signs a banner displaying the new name of the Operations and Checkout Building at NASA's Kennedy Space Center in Florida. The banner signing followed a ceremony renaming the refurbished building for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. The building's high bay is being used to support the agency's new Orion spacecraft and is the same spaceport facility where the Apollo 11 command/service module and lunar module were prepped for the first lunar landing mission in 1969. Orion is designed to take humans farther than they’ve ever gone before, serving as the exploration vehicle that will carry astronauts to deep space and sustain the crew during travel to destinations such as an asteroid or Mars. The ceremony was part of NASA's 45th anniversary celebration of the Apollo 11 moon landing. As the world watched, Neil Armstrong and Buzz Aldrin landed in the moon's Sea of Tranquility on July 20, 1969, aboard the lunar module Eagle. Meanwhile, crewmate Michael Collins orbited above in the command module Columbia. For more, visit http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission. Photo credit: NASA/Kevin O'Connell

KSC-2014-3208

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- At the Kennedy Space Center in Florida, Center Director Robert Cabana, left, and NASA Administrator Charles Bolden participate a ceremony renaming the refurbished Operations and Checkout Building for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. The building's high bay is being used to support the agency's new Orion spacecraft and is the same spaceport facility where the Apollo 11 command/service module and lunar module were prepped for the first lunar landing mission in 1969. Orion is designed to take humans farther than they’ve ever gone before, serving as the exploration vehicle that will carry astronauts to deep space and sustain the crew during travel to destinations such as an asteroid or Mars. The ceremony was part of NASA's 45th anniversary celebration of the Apollo 11 moon landing. As the world watched, Neil Armstrong and Buzz Aldrin landed in the moon's Sea of Tranquility on July 20, 1969, aboard the lunar module Eagle. Meanwhile, crewmate Michael Collins orbited above in the command module Columbia. For more, visit http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission. Photo credit: NASA/Kim Shiflett

KSC-2014-3212

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- At the Kennedy Space Center in Florida, Apollo 11 astronaut Michael Collins addresses the audience at a ceremony renaming the refurbished Operations and Checkout Building for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. The building's high bay is being used to support the agency's new Orion spacecraft and is the same spaceport facility where the Apollo 11 command/service module and lunar module were prepped for the first lunar landing mission in 1969. Orion is designed to take humans farther than they’ve ever gone before, serving as the exploration vehicle that will carry astronauts to deep space and sustain the crew during travel to destinations such as an asteroid or Mars. The ceremony was part of NASA's 45th anniversary celebration of the Apollo 11 moon landing. As the world watched, Neil Armstrong and Buzz Aldrin landed in the moon's Sea of Tranquility on July 20, 1969, aboard the lunar module Eagle. Meanwhile, crewmate Michael Collins orbited above in the command module Columbia. For more, visit http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission. Photo credit: NASA/Kim Shiflett

KSC-2014-3231

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- At the Kennedy Space Center in Florida, Apollo astronauts tour the refurbished Operations and Checkout Building, newly named for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. Viewing the Orion crew module stacked on top of the service module from left, are Apollo 11 astronaut Michael Collins, Apollo astronaut Jim Lovell, and Apollo 11 astronaut Buzz Aldrin. The building's high bay is being used to support the agency's new Orion spacecraft, which will lift off atop the Space Launch System. Orion is designed to take humans farther than they've ever gone before, serving as the exploration vehicle that will carry astronauts to deep space and sustain the crew during travel to destinations such as an asteroid or Mars. The visit of the former astronauts was part of NASA's 45th anniversary celebration of the moon landing. As the world watched, Neil Armstrong and Aldrin landed in the moon's Sea of Tranquility aboard the lunar module Eagle on July 20, 1969. Meanwhile, crewmate Collins orbited above in the command module Columbia. For more, visit http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission. Photo credit: NASA/Kim Shiflett

KSC-2014-3206

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- At the Kennedy Space Center in Florida, Center Director Robert Cabana addresses the audience at a ceremony renaming the refurbished Operations and Checkout Building for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. The building's high bay is being used to support the agency's new Orion spacecraft and is the same spaceport facility where the Apollo 11 command/service module and lunar module were prepped for the first lunar landing mission in 1969. Orion is designed to take humans farther than they’ve ever gone before, serving as the exploration vehicle that will carry astronauts to deep space and sustain the crew during travel to destinations such as an asteroid or Mars. The ceremony was part of NASA's 45th anniversary celebration of the Apollo 11 moon landing. As the world watched, Neil Armstrong and Buzz Aldrin landed in the moon's Sea of Tranquility on July 20, 1969, aboard the lunar module Eagle. Meanwhile, crewmate Michael Collins orbited above in the command module Columbia. For more, visit http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission. Photo credit: NASA/Kim Shiflett

KSC-2014-3204

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- At the Kennedy Space Center in Florida, Apollo 11 astronaut Buzz Aldrin participates in a ceremony renaming the refurbished Operations and Checkout Building for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. The building's high bay is being used to support the agency's new Orion spacecraft and is the same spaceport facility where the Apollo 11 command/service module and lunar module were prepped for the first lunar landing mission in 1969. Orion is designed to take humans farther than they’ve ever gone before, serving as the exploration vehicle that will carry astronauts to deep space and sustain the crew during travel to destinations such as an asteroid or Mars. The ceremony was part of NASA's 45th anniversary celebration of the Apollo 11 moon landing. As the world watched, Neil Armstrong and Buzz Aldrin landed in the moon's Sea of Tranquility on July 20, 1969, aboard the lunar module Eagle. Meanwhile, crewmate Michael Collins orbited above in the command module Columbia. For more, visit http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission. Photo credit: NASA/Kim Shiflett

KSC-2014-3219

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- At the Kennedy Space Center in Florida, media representatives turn out for a ceremony renaming the refurbished Operations and Checkout Building for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. The building's high bay, in which the ceremony was held, is being used to support the agency's new Orion spacecraft and is the same spaceport facility where the Apollo 11 command/service module and lunar module were prepped for the first lunar landing mission in 1969. Orion is designed to take humans farther than they’ve ever gone before, serving as the exploration vehicle that will carry astronauts to deep space and sustain the crew during travel to destinations such as an asteroid or Mars. The ceremony was part of NASA's 45th anniversary celebration of the Apollo 11 moon landing. As the world watched, Neil Armstrong and Buzz Aldrin landed in the moon's Sea of Tranquility on July 20, 1969, aboard the lunar module Eagle. Meanwhile, crewmate Michael Collins orbited above in the command module Columbia. For more, visit http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission. Photo credit: NASA/Kim Shiflett

KSC-2014-3209

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- At the Kennedy Space Center in Florida, Apollo astronauts participate in a ceremony renaming the refurbished Operations and Checkout Building for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. From left are Jim Lovell, Buzz Aldrin and Michael Collins. The building's high bay is being used to support the agency's new Orion spacecraft and is the same spaceport facility where the Apollo 11 command/service module and lunar module were prepped for the first lunar landing mission in 1969. Orion is designed to take humans farther than they’ve ever gone before, serving as the exploration vehicle that will carry astronauts to deep space and sustain the crew during travel to destinations such as an asteroid or Mars. The ceremony was part of NASA's 45th anniversary celebration of the Apollo 11 moon landing. As the world watched, Neil Armstrong and Buzz Aldrin landed in the moon's Sea of Tranquility on July 20, 1969, aboard the lunar module Eagle. Meanwhile, crewmate Michael Collins orbited above in the command module Columbia. For more, visit http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission. Photo credit: NASA/Kim Shiflett

KSC-2014-3223

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- At the Kennedy Space Center in Florida, Apollo 11 astronaut Michael Collins gets a close look at an Apollo-era spacesuit following its unveiling in the lobby of the newly named Neil Armstrong Operations and Checkout Building. The facility has been renamed for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. The building's high bay is being used to support the agency's new Orion spacecraft and is the same spaceport facility where the Apollo 11 command/service module and lunar module were prepped for the first lunar landing mission in 1969. Orion is designed to take humans farther than they’ve ever gone before, serving as the exploration vehicle that will carry astronauts to deep space and sustain the crew during travel to destinations such as an asteroid or Mars. The unveiling was part of NASA's 45th anniversary celebration of the Apollo 11 moon landing. As the world watched, Apollo 11 astronauts landed in the moon's Sea of Tranquility aboard the lunar module, Eagle, on July 20, 1969, as the command module, Columbia, orbited overhead. For more: http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission/ Photo credit: NASA/Kim Shiflett

KSC-2014-3199

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- At the Kennedy Space Center in Florida, NASA officials and Apollo astronauts have a group portrait taken in front of the refurbished Operations and Checkout Building, newly named for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. From left are NASA Administrator Charles Bolden, Apollo astronauts Mike Collins, Buzz Aldrin and Jim Lovell, and Center Director Robert Cabana. The building's high bay is being used to support the agency's new Orion spacecraft, which will lift off atop the Space Launch System rocket. Orion is designed to take humans farther than they’ve ever gone before, serving as the exploration vehicle that will carry astronauts to deep space and sustain the crew during travel to destinations such as an asteroid or Mars. The visit of the former astronauts was part of NASA's 45th anniversary celebration of the Apollo 11 moon landing. As the world watched, Neil Armstrong and Aldrin landed in the moon's Sea of Tranquility aboard the lunar module Eagle on July 20, 1969. Meanwhile, crewmate Collins orbited above in the command module Columbia. For more, visit http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission. Photo credit: NASA/Kevin O'Connell

KSC-2014-3211

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- At the Kennedy Space Center in Florida, Apollo 11 astronaut Buzz Aldrin addresses the audience at a ceremony renaming the refurbished Operations and Checkout Building for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. The building's high bay is being used to support the agency's new Orion spacecraft and is the same spaceport facility where the Apollo 11 command/service module and lunar module were prepped for the first lunar landing mission in 1969. Orion is designed to take humans farther than they’ve ever gone before, serving as the exploration vehicle that will carry astronauts to deep space and sustain the crew during travel to destinations such as an asteroid or Mars. The ceremony was part of NASA's 45th anniversary celebration of the Apollo 11 moon landing. As the world watched, Neil Armstrong and Buzz Aldrin landed in the moon's Sea of Tranquility on July 20, 1969, aboard the lunar module Eagle. Meanwhile, crewmate Michael Collins orbited above in the command module Columbia. For more, visit http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission. Photo credit: NASA/Kim Shiflett

KSC-2014-3221

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- At the Kennedy Space Center in Florida, Center Director Robert Cabana, left, and NASA Administrator Charles Bolden unveil a plaque on display in the lobby of the newly named Neil Armstrong Operations and Checkout Building. The facility has been renamed for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. The building's high bay is being used to support the agency's new Orion spacecraft and is the same spaceport facility where the Apollo 11 command/service module and lunar module were prepped for the first lunar landing mission in 1969. Orion is designed to take humans farther than they’ve ever gone before, serving as the exploration vehicle that will carry astronauts to deep space and sustain the crew during travel to destinations such as an asteroid or Mars. The unveiling was part of NASA's 45th anniversary celebration of the Apollo 11 moon landing. As the world watched, Apollo 11 astronauts landed in the moon's Sea of Tranquility aboard the lunar module, Eagle, on July 20, 1969, as the command module, Columbia, orbited overhead. For more: http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission/ Photo credit: NASA/Kim Shiflett

KSC-2014-3210

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- At the Kennedy Space Center in Florida, Apollo astronaut Jim Lovell addresses the audience at a ceremony renaming the refurbished Operations and Checkout Building for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. Lovell served on the crews of Apollo 8 and Apollo 13. The building's high bay is being used to support the agency's new Orion spacecraft and is the same spaceport facility where the Apollo 11 command/service module and lunar module were prepped for the first lunar landing mission in 1969. Orion is designed to take humans farther than they’ve ever gone before, serving as the exploration vehicle that will carry astronauts to deep space and sustain the crew during travel to destinations such as an asteroid or Mars. The ceremony was part of NASA's 45th anniversary celebration of the Apollo 11 moon landing. As the world watched, Neil Armstrong and Buzz Aldrin landed in the moon's Sea of Tranquility on July 20, 1969, aboard the lunar module Eagle. Meanwhile, crewmate Michael Collins orbited above in the command module Columbia. For more, visit http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission. Photo credit: NASA/Kim Shiflett

KSC-2014-3220

NASA Image and Video Library

2014-07-21

KSC-2014-3220 – CAPE CANAVERAL, Fla. -- At the Kennedy Space Center in Florida, Center Director Robert Cabana unveils an Apollo-era spacesuit on display in the lobby of the newly named Neil Armstrong Operations and Checkout Building. The facility has been renamed for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. The building's high bay is being used to support the agency's new Orion spacecraft and is the same spaceport facility where the Apollo 11 command/service module and lunar module were prepped for the first lunar landing mission in 1969. Orion is designed to take humans farther than they’ve ever gone before, serving as the exploration vehicle that will carry astronauts to deep space and sustain the crew during travel to destinations such as an asteroid or Mars. The unveiling was part of NASA's 45th anniversary celebration of the Apollo 11 moon landing. As the world watched, Apollo 11 astronauts landed in the moon's Sea of Tranquility aboard the lunar module, Eagle, on July 20, 1969, as the command module, Columbia, orbited overhead. For more: http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission/ Photo credit: NASA/Kim Shiflett

Expression and purification of active mouse and human NEIL3 proteins

PubMed Central

Liu, Minmin; Bandaru, Viswanath; Holmes, Alicia; Averill, April M.; Cannan, Wendy

2012-01-01

Endonuclease VIII-like 3 (Neil3) is one of the five DNA glycosylases found in mammals that recognize and remove oxidized bases, and initiate the Base Excision Repair (BER) pathway. Previous attempts to express and purify the mouse and human orthologs of Neil3 in their active form have not been successful. Here we report the construction of bicistronic expression vectors for expressing in Escherichia coli the full-length mouse Neil3 (MmuNeil3), its glycosylase domain (MmuNeil3Δ324), as well as the glycosylase domain of human Neil3 (NEIL3Δ324). The purified Neil3 proteins are all active, and NEIL3Δ324 exhibits similar glycosylase/lyase activity as MmuNeil3Δ324 on both single-stranded and double-stranded substrates containing thymine glycol (Tg), spiroiminodihydantoin (Sp) or an abasic site (AP). We show that N-terminal initiator methionine processing is critical for the activity of both mouse and human Neil3 proteins. Co-expressing an E. coli methionine aminopeptidase (EcoMap) Y168A variant with MmuNeil3, MmuNeil3Δ324 and NEIL3Δ324 improves the N-terminal methionine processing and increases the percentage of active Neil3 proteins in the preparation. The purified Neil3 proteins are suitable for biochemical, structural and functional studies. PMID:22569481

KSC-98pc492

NASA Image and Video Library

1998-04-17

KENNEDY SPACE CENTER, FLA. -- STS-90 Pilot Scott Altman is assisted during suit-up activities by Lockheed Suit Technician Valerie McNeil from Johnson Space Center in KSC's Operations and Checkout Building. Altman and the rest of the STS-90 crew will shortly depart for Launch Pad 39B, where the Space Shuttle Columbia awaits a second liftoff attempt at 2:19 p.m. EDT. His first trip into space, Altman is participating in a life sciences research flight that will focus on the most complex and least understood part of the human body the nervous system. Neurolab will examine the effects of spaceflight on the brain, spinal cord, peripheral nerves and sensory organs in the human body

KSC-2014-4117

NASA Image and Video Library

2014-09-25

CAPE CANAVERAL, Fla. – NASA astronaut Rick Mastracchio takes questions on the execution of the Slosh experiment from employees attending the Launch Services Program's All Hands meeting in the Neil Armstrong Operations and Checkout Building Mission Briefing Room at NASA's Kennedy Space Center in Florida. An Expedition 38/39 crew member, Mastracchio launched to the station from the Baikonur Cosmodrome in Kazakhstan on Nov. 6, 2013, and returned to Earth on May 13, 2014, after 188 days in space. To read Mastracchio's biography, visit http://www.jsc.nasa.gov/Bios/htmlbios/mastracc.html. For more information on the Slosh experiment, visit http://www.nasa.gov/content/slosh-experiment-designed-to-improve-rocket-safety-efficiency/. Photo credit: NASA/Daniel Casper

KSC-2014-4115

NASA Image and Video Library

2014-09-25

CAPE CANAVERAL, Fla. – NASA astronaut Rick Mastracchio recounts his experiences conducting the Slosh experiment on the International Space Station to employees attending the Launch Services Program's All Hands meeting in the Neil Armstrong Operations and Checkout Building Mission Briefing Room at NASA's Kennedy Space Center in Florida. An Expedition 38/39 crew member, Mastracchio launched to the station from the Baikonur Cosmodrome in Kazakhstan on Nov. 6, 2013, and returned to Earth on May 13, 2014, after 188 days in space. To read Mastracchio's biography, visit http://www.jsc.nasa.gov/Bios/htmlbios/mastracc.html. For more information on the Slosh experiment, visit http://www.nasa.gov/content/slosh-experiment-designed-to-improve-rocket-safety-efficiency/. Photo credit: NASA/Daniel Casper

KSC-2014-3226

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- At the Kennedy Space Center in Florida, NASA officials and Apollo astronauts tour the refurbished Operations and Checkout Building, newly named for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. From left, are Apollo 11 astronaut Buzz Aldrin, Mark Geyer, Orion Program manager, and Scott Wilson, manager, production operations for the Orion Program. Also at the renaming ceremony were Apollo astronauts Michael Collins and Jim Lovell. The building's high bay is being used to support the agency's new Orion spacecraft, which will lift off atop the Space Launch System. Orion is designed to take humans farther than they've ever gone before, serving as the exploration vehicle that will carry astronauts to deep space and sustain the crew during travel to destinations such as an asteroid or Mars. The visit of the former astronauts was part of NASA's 45th anniversary celebration of the moon landing. As the world watched, Neil Armstrong and Aldrin landed in the moon's Sea of Tranquility aboard the lunar module Eagle on July 20, 1969. Meanwhile, crewmate Collins orbited above in the command module Columbia. For more, visit http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission. Photo credit: NASA/Kim Shiflett

KSC-2014-3224

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- At the Kennedy Space Center in Florida, members of the Armstrong family pose for a portrait with an Apollo-era spacesuit following its unveiling in the lobby of the newly named Neil Armstrong Operations and Checkout Building. The facility has been renamed for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. From left are Armstrong's son Mark, his grandson Bryce, his son Rick and his granddaughter Lily. The building's high bay is being used to support the agency's new Orion spacecraft and is the same spaceport facility where the Apollo 11 command/service module and lunar module were prepped for the first lunar landing mission in 1969. Orion is designed to take humans farther than they’ve ever gone before, serving as the exploration vehicle that will carry astronauts to deep space and sustain the crew during travel to destinations such as an asteroid or Mars. The unveiling was part of NASA's 45th anniversary celebration of the Apollo 11 moon landing. As the world watched, Apollo 11 astronauts landed in the moon's Sea of Tranquility aboard the lunar module, Eagle, on July 20, 1969, as the command module, Columbia, orbited overhead. For more: http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission/ Photo credit: NASA/Kim Shiflett

KSC-2014-3243

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- Apollo astronaut Michael Collins tours the astronaut crew quarters in the Operations and Checkout Building at NASA's Kennedy Space Center in Florida, accompanied by family members and friends. The tour followed a ceremony renaming the refurbished Operations and Checkout Building for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. Besides housing the crew quarters, the building's high bay is being used to support the agency's new Orion spacecraft and is the same spaceport facility where the Apollo 11 command/service module and lunar module were prepped for the first lunar landing mission in 1969. Orion is designed to take humans farther than they’ve ever gone before, serving as the exploration vehicle that will carry astronauts to deep space and sustain the crew during travel to destinations such as an asteroid or Mars. The visit of the former astronauts was part of NASA's 45th anniversary celebration of the moon landing. As the world watched, Neil Armstrong and Aldrin landed in the moon's Sea of Tranquility aboard the lunar module Eagle on July 20, 1969. Meanwhile, crewmate Collins orbited above in the command module Columbia. For more, visit http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission. Photo credit: NASA/Kim Shiflett

KSC-2014-3232

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- At the Kennedy Space Center in Florida, NASA officials and Apollo astronauts tour the refurbished Operations and Checkout Building, newly named for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. Viewing the Orion crew module stacked on top of the service module from left, are Kennedy Center Director Bob Cabana, Apollo 11 astronaut Michael Collins, Apollo astronaut Jim Lovell, Apollo 11 astronaut Buzz Aldrin, and NASA Administrator Charlie Bolden. The building's high bay is being used to support the agency's new Orion spacecraft, which will lift off atop the Space Launch System. Orion is designed to take humans farther than they've ever gone before, serving as the exploration vehicle that will carry astronauts to deep space and sustain the crew during travel to destinations such as an asteroid or Mars. The visit of the former astronauts was part of NASA's 45th anniversary celebration of the moon landing. As the world watched, Neil Armstrong and Aldrin landed in the moon's Sea of Tranquility aboard the lunar module Eagle on July 20, 1969. Meanwhile, crewmate Collins orbited above in the command module Columbia. For more, visit http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission. Photo credit: NASA/Kim Shiflett

KSC-2014-3202

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- At the Kennedy Space Center in Florida, the family of Neil Armstrong poses for a group portrait in front of the refurbished Operations and Checkout Building. From left are Armstrong's son Mark, his former wife Janet, his granddaughter Lily, his son Rick and his grandson Bryce. Armstrong, an Apollo 11 astronaut, was the first person to set foot on the moon and for whom the facility is newly named. The building's high bay is being used to support the agency's new Orion spacecraft, which will lift off atop the Space Launch System rocket. Orion is designed to take humans farther than they’ve ever gone before, serving as the exploration vehicle that will carry astronauts to deep space and sustain the crew during travel to destinations such as an asteroid or Mars. The visit of the former astronauts was part of NASA's 45th anniversary celebration of the Apollo 11 moon landing. As the world watched, Neil Armstrong and Aldrin landed in the moon's Sea of Tranquility aboard the lunar module Eagle on July 20, 1969. Meanwhile, crewmate Collins orbited above in the command module Columbia. For more, visit http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission. Photo credit: NASA/Kevin O'Connell

KSC-2014-3251

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- At NASA's Kennedy Space Center in Florida, NASA Administrator Charles Bolden, left, signs a banner displaying the new name of the Operations and Checkout Building, as Apollo 11 moonwalker Buzz Aldrin prepares to sign. The banner signing followed a ceremony renaming the refurbished Operations and Checkout Building for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. The building's high bay is being used to support the agency's new Orion spacecraft and is the same spaceport facility where the Apollo 11 command/service module and lunar module were prepped for the first lunar landing mission in 1969. Orion is designed to take humans farther than they’ve ever gone before, serving as the exploration vehicle that will carry astronauts to deep space and sustain the crew during travel to destinations such as an asteroid or Mars. The ceremony was part of NASA's 45th anniversary celebration of the Apollo 11 moon landing. As the world watched, Neil Armstrong and Buzz Aldrin landed in the moon's Sea of Tranquility on July 20, 1969, aboard the lunar module Eagle. Meanwhile, crewmate Michael Collins orbited above in the command module Columbia. For more, visit http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission. Photo credit: NASA/Kevin O'Connell

KSC-2014-3242

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- Apollo astronauts Jim Lovell, left, and Buzz Aldrin tour the astronaut crew quarters in the Operations and Checkout Building at NASA's Kennedy Space Center in Florida. The tour followed a ceremony renaming the refurbished Operations and Checkout Building for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. Besides housing the crew quarters, the building's high bay is being used to support the agency's new Orion spacecraft and is the same spaceport facility where the Apollo 11 command/service module and lunar module were prepped for the first lunar landing mission in 1969. Orion is designed to take humans farther than they’ve ever gone before, serving as the exploration vehicle that will carry astronauts to deep space and sustain the crew during travel to destinations such as an asteroid or Mars. The visit of the former astronauts was part of NASA's 45th anniversary celebration of the moon landing. As the world watched, Neil Armstrong and Aldrin landed in the moon's Sea of Tranquility aboard the lunar module Eagle on July 20, 1969. Meanwhile, crewmate Collins orbited above in the command module Columbia. For more, visit http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission. Photo credit: NASA/Kim Shiflett

KSC-2014-3239

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- Apollo 11 astronaut Michael Collins checks out some equipment during a tour of the astronaut crew quarters in the Operations and Checkout Building at NASA's Kennedy Space Center in Florida. The tour followed a ceremony renaming the refurbished Operations and Checkout Building for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. Besides housing the crew quarters, the building's high bay is being used to support the agency's new Orion spacecraft and is the same spaceport facility where the Apollo 11 command/service module and lunar module were prepped for the first lunar landing mission in 1969. Orion is designed to take humans farther than they’ve ever gone before, serving as the exploration vehicle that will carry astronauts to deep space and sustain the crew during travel to destinations such as an asteroid or Mars. The visit of the former astronauts was part of NASA's 45th anniversary celebration of the moon landing. As the world watched, Neil Armstrong and Aldrin landed in the moon's Sea of Tranquility aboard the lunar module Eagle on July 20, 1969. Meanwhile, crewmate Collins orbited above in the command module Columbia. For more, visit http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission. Photo credit: NASA/Kim Shiflett

KSC-2014-3227

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- At the Kennedy Space Center in Florida, NASA officials and Apollo astronauts tour the refurbished Operations and Checkout Building, newly named for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. Leading the way at left is Kennedy Center Director Bob Cabana, Scott Wilson, manager, production operations for the Orion Program, and Apollo 11 astronaut Michael Collins. At right is Apollo 11 astronaut Buzz Aldrin, and Mark Geyer, Orion Program manager. The building's high bay is being used to support the agency's new Orion spacecraft, which will lift off atop the Space Launch System. Orion is designed to take humans farther than they've ever gone before, serving as the exploration vehicle that will carry astronauts to deep space and sustain the crew during travel to destinations such as an asteroid or Mars. The visit of the former astronauts was part of NASA's 45th anniversary celebration of the moon landing. As the world watched, Neil Armstrong and Aldrin landed in the moon's Sea of Tranquility aboard the lunar module Eagle on July 20, 1969. Meanwhile, crewmate Collins orbited above in the command module Columbia. For more, visit http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission. Photo credit: NASA/Kim Shiflett

KSC-2014-3225

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- At the Kennedy Space Center in Florida, members of the Armstrong family pose beside a plaque following its unveiling in the lobby of the newly named Neil Armstrong Operations and Checkout Building. The facility has been renamed for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. From left are Armstrong's son Mark, his former wife Janet, his son Rick, his grandson Bryce, and his granddaughter Lily. The building's high bay is being used to support the agency's new Orion spacecraft and is the same spaceport facility where the Apollo 11 command/service module and lunar module were prepped for the first lunar landing mission in 1969. Orion is designed to take humans farther than they’ve ever gone before, serving as the exploration vehicle that will carry astronauts to deep space and sustain the crew during travel to destinations such as an asteroid or Mars. The unveiling was part of NASA's 45th anniversary celebration of the Apollo 11 moon landing. As the world watched, Apollo 11 astronauts landed in the moon's Sea of Tranquility aboard the lunar module, Eagle, on July 20, 1969, as the command module, Columbia, orbited overhead. For more: http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission/ Photo credit: NASA/Kim Shiflett

KSC-2014-3254

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- A banner displaying the new name of the Operations and Checkout Building at NASA's Kennedy Space Center in Florida is signed by Apollo astronauts and their families. The banner signing followed a ceremony renaming the refurbished building for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. The building's high bay is being used to support the agency's new Orion spacecraft and is the same spaceport facility where the Apollo 11 command/service module and lunar module were prepped for the first lunar landing mission in 1969. The Orion spacecraft is designed to take humans farther than they’ve ever gone before, serving as the exploration vehicle that will carry astronauts to deep space and sustain the crew during travel to destinations such as an asteroid or Mars. Orion's first flight will be Exploration Fight Test-1, planned for December 2014. The ceremony was part of NASA's 45th anniversary celebration of the Apollo 11 moon landing. As the world watched, Neil Armstrong and Buzz Aldrin landed in the moon's Sea of Tranquility on July 20, 1969, aboard the lunar module Eagle. Meanwhile, crewmate Michael Collins orbited above in the command module Columbia. For more, visit http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission. Photo credit: NASA/Kevin O'Connell

KSC-2014-3222

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- At the Kennedy Space Center in Florida, Center Director Robert Cabana reads the inscription on a plaque to invited guests following its unveiling in the lobby of the newly named Neil Armstrong Operations and Checkout Building. NASA Administrator Charles Bolden is at his right. The facility has been renamed for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. The building's high bay is being used to support the agency's new Orion spacecraft and is the same spaceport facility where the Apollo 11 command/service module and lunar module were prepped for the first lunar landing mission in 1969. Orion is designed to take humans farther than they’ve ever gone before, serving as the exploration vehicle that will carry astronauts to deep space and sustain the crew during travel to destinations such as an asteroid or Mars. The unveiling was part of NASA's 45th anniversary celebration of the Apollo 11 moon landing. As the world watched, Apollo 11 astronauts landed in the moon's Sea of Tranquility aboard the lunar module, Eagle, on July 20, 1969, as the command module, Columbia, orbited overhead. For more: http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission/ Photo credit: NASA/Kim Shiflett

Ubiquitylation-dependent regulation of NEIL1 by Mule and TRIM26 is required for the cellular DNA damage response.

PubMed

Edmonds, Matthew J; Carter, Rachel J; Nickson, Catherine M; Williams, Sarah C; Parsons, Jason L

2017-01-25

Endonuclease VIII-like protein 1 (NEIL1) is a DNA glycosylase involved in initiating the base excision repair pathway, the major cellular mechanism for repairing DNA base damage. Here, we have purified the major E3 ubiquitin ligases from human cells responsible for regulation of NEIL1 by ubiquitylation. Interestingly, we have identified two enzymes that catalyse NEIL1 polyubiquitylation, Mcl-1 ubiquitin ligase E3 (Mule) and tripartite motif 26 (TRIM26). We demonstrate that these enzymes are capable of polyubiquitylating NEIL1 in vitro, and that both catalyse ubiquitylation of NEIL1 within the same C-terminal lysine residues. An siRNA-mediated knockdown of Mule or TRIM26 leads to stabilisation of NEIL1, demonstrating that these enzymes are important in regulating cellular NEIL1 steady state protein levels. Similarly, a mutant NEIL1 protein lacking residues for ubiquitylation is more stable than the wild type protein in vivo We also demonstrate that cellular NEIL1 protein is induced in response to ionising radiation (IR), although this occurs specifically in a Mule-dependent manner. Finally we show that stabilisation of NEIL1, particularly following TRIM26 siRNA, contributes to cellular resistance to IR. This highlights the importance of Mule and TRIM26 in maintaining steady state levels of NEIL1, but also those required for the cellular DNA damage response. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

KSC-2011-5965

NASA Image and Video Library

2011-07-25

CAPE CANAVERAL, Fla. -- The Apollo/Saturn V Center at NASA's Kennedy Space Center in Florida hosted a celebration on the 40th anniversary of NASA's Apollo 15 mission. Apollo 15 Commander Dave Scott, Command Module Pilot Al Worden and an elite gathering of Apollo-era astronauts were on hand for the event and panel discussion. Here, Apollo 11 Commander Neil Armstrong speaks to the invited guests. Worden circled the moon while Scott and the late Jim Irwin, the Lunar Module commander, made history when they became the first humans to drive a vehicle on the surface of the moon. They also provided extensive descriptions and photographic documentation of geologic features in the vicinity of the Hadley Rille landing site during their three days on the lunar surface. Photo credit: NASA/Kim Shiflett

KSC-99pp0874

NASA Image and Video Library

1999-07-16

KENNEDY SPACE CENTER, FLA. -- NASA Administrator Daniel S. Goldin addresses the audience at the Apollo 11 anniversary banquet honoring the Apollo team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Among the guests at the banquet were former Apollo astronauts are Neil A. Armstrong and Edwin "Buzz" Aldrin who flew on Apollo 11, the launch of the first moon landing; Gene Cernan, who flew on Apollo 10 and 17 and was the last man to walk on the moon; and Walt Cunningham, who flew on Apollo 7

KSC-2014-4116

NASA Image and Video Library

2014-09-25

CAPE CANAVERAL, Fla. – NASA astronaut Rick Mastracchio, standing at left, illustrates the fine points of conducting the Slosh experiment on the International Space Station for employees attending the Launch Services Program's All Hands meeting in the Neil Armstrong Operations and Checkout Building Mission Briefing Room at NASA's Kennedy Space Center in Florida. An Expedition 38/39 crew member, Mastracchio launched to the station from the Baikonur Cosmodrome in Kazakhstan on Nov. 6, 2013, and returned to Earth on May 13, 2014, after 188 days in space. To read Mastracchio's biography, visit http://www.jsc.nasa.gov/Bios/htmlbios/mastracc.html. For more information on the Slosh experiment, visit http://www.nasa.gov/content/slosh-experiment-designed-to-improve-rocket-safety-efficiency/. Photo credit: NASA/Daniel Casper

KSC-99pp0939

NASA Image and Video Library

1999-07-16

KENNEDY SPACE CENTER, FLA. -- George Meguiar (left) presents a scholarship award to Kyla Davis Horn, of Cocoa Beach, one of the winners of an essay contest related to the 30th Anniversary of Apollo 11. Meguiar and George English (second from right) head the Apollo 11 Commemoration Association who sponsored the contest in conjunction with Florida Today newspaper. The other scholarship winner is Kyle Rukaczewski, of Satellite Beach (far right). A third winner, Jason Gagnon, of Viera, was unable to attend. The presentation was made at the Apollo/Saturn V Center during an anniversary banquet that honored all the people who made the Apollo Program possible. Special guests included former Apollo astronauts Neil Armstrong, Edwin "Buzz" Aldrin, Gene Cernan and Walt Cunningham, who shared their experiences with the audience

KSC-04PD-0792

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. -- Neil Yorio, a Dynamac scientist(left), explains the function of the KSC Space Life Sciences (SLS) Lab to a prestigious tour group: (from left) Florida Gov. Jeb Bush and his wife, Columba; NASA Administrator Sean OKeefe and his wife, Laura; and U.S. Mint Director Henrietta Holsman Fore. The new lab is a state-of-the-art facility built for ISS biotechnology research. It was developed as a partnership between NASA-KSC and the State of Florida. The tour followed the launching ceremony at the KSC Visitor Complex for the new Florida quarter issued by the U.S. Mint. The ceremony was emceed by Center Director Jim Kennedy and included remarks by OKeefe, Bush, Fore and Deputy Secretary of the Treasury Samuel W. Bodman.

KSC-04PD-0793

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. -- Neil Yorio, a Dynamac scientist (left) in the KSC Space Life Sciences (SLS) Lab, explains the function of the facility to Florida Gov. Jeb Bush and his wife, Columba. Bush and others were touring the Lab following the launching ceremony at the KSC Visitor Complex for the new Florida quarter issued by the U.S. Mint. . The new lab is a state-of-the- art facility built for ISS biotechnology research. It was developed as a partnership between NASA-KSC and the State of Florida. The launching ceremony was emceed by Center Director Jim Kennedy and included remarks by NASA Administrator Sean OKeefe, Bush, U.S. Mint Director Henrietta Holsman Fore and Deputy Secretary of the Treasury Samuel W. Bodman.

KSC-04PD-0788

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. -- Following the launching ceremony at the KSC Visitor Complex for the new Florida quarter issued by the U.S. Mint, NASA Administrator Sean OKeefe (far left), Gov. Jeb Bush (center), U.S. Mint Director Henrietta Holsman Fore (center right) and Center Director Jim Kennedy (in front of Neil Yorio, a Dynamac scientist, at right) tour the KSC Space Life Sciences (SLS) Lab. The new lab is a state-of-the-art facility built for ISS biotechnology research. It was developed as a partnership between NASA-KSC and the State of Florida. Next to OKeefe is Bernadette Kennedy, wife of the Center Director. The launching ceremony was emceed by Kennedy and included remarks by OKeefe, Bush, Fore and Deputy Secretary of the Treasury Samuel W. Bodman.

NEIL3 Repairs Telomere Damage during S Phase to Secure Chromosome Segregation at Mitosis.

PubMed

Zhou, Jia; Chan, Jany; Lambelé, Marie; Yusufzai, Timur; Stumpff, Jason; Opresko, Patricia L; Thali, Markus; Wallace, Susan S

2017-08-29

Oxidative damage to telomere DNA compromises telomere integrity. We recently reported that the DNA glycosylase NEIL3 preferentially repairs oxidative lesions in telomere sequences in vitro. Here, we show that loss of NEIL3 causes anaphase DNA bridging because of telomere dysfunction. NEIL3 expression increases during S phase and reaches maximal levels in late S/G2. NEIL3 co-localizes with TRF2 and associates with telomeres during S phase, and this association increases upon oxidative stress. Mechanistic studies reveal that NEIL3 binds to single-stranded DNA via its intrinsically disordered C terminus in a telomere-sequence-independent manner. Moreover, NEIL3 is recruited to telomeres through its interaction with TRF1, and this interaction enhances the enzymatic activity of purified NEIL3. Finally, we show that NEIL3 interacts with AP Endonuclease 1 (APE1) and the long-patch base excision repair proteins PCNA and FEN1. Taken together, we propose that NEIL3 protects genome stability through targeted repair of oxidative damage in telomeres during S/G2 phase. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

Neil2-null Mice Accumulate Oxidized DNA Bases in the Transcriptionally Active Sequences of the Genome and Are Susceptible to Innate Inflammation* ♦

PubMed Central

Chakraborty, Anirban; Wakamiya, Maki; Venkova-Canova, Tatiana; Pandita, Raj K.; Aguilera-Aguirre, Leopoldo; Sarker, Altaf H.; Singh, Dharmendra Kumar; Hosoki, Koa; Wood, Thomas G.; Sharma, Gulshan; Cardenas, Victor; Sarkar, Partha S.; Sur, Sanjiv; Pandita, Tej K.; Boldogh, Istvan; Hazra, Tapas K.

2015-01-01

Why mammalian cells possess multiple DNA glycosylases (DGs) with overlapping substrate ranges for repairing oxidatively damaged bases via the base excision repair (BER) pathway is a long-standing question. To determine the biological role of these DGs, null animal models have been generated. Here, we report the generation and characterization of mice lacking Neil2 (Nei-like 2). As in mice deficient in each of the other four oxidized base-specific DGs (OGG1, NTH1, NEIL1, and NEIL3), Neil2-null mice show no overt phenotype. However, middle-aged to old Neil2-null mice show the accumulation of oxidative genomic damage, mostly in the transcribed regions. Immuno-pulldown analysis from wild-type (WT) mouse tissue showed the association of NEIL2 with RNA polymerase II, along with Cockayne syndrome group B protein, TFIIH, and other BER proteins. Chromatin immunoprecipitation analysis from mouse tissue showed co-occupancy of NEIL2 and RNA polymerase II only on the transcribed genes, consistent with our earlier in vitro findings on NEIL2's role in transcription-coupled BER. This study provides the first in vivo evidence of genomic region-specific repair in mammals. Furthermore, telomere loss and genomic instability were observed at a higher frequency in embryonic fibroblasts from Neil2-null mice than from the WT. Moreover, Neil2-null mice are much more responsive to inflammatory agents than WT mice. Taken together, our results underscore the importance of NEIL2 in protecting mammals from the development of various pathologies that are linked to genomic instability and/or inflammation. NEIL2 is thus likely to play an important role in long term genomic maintenance, particularly in long-lived mammals such as humans. PMID:26245904

76. (Credit CBF) Inside of laboratory at McNeil Street Station, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

76. (Credit CBF) Inside of laboratory at McNeil Street Station, c1912. Laboratory located over clear water well at this time. - McNeil Street Pumping Station, McNeil Street & Cross Bayou, Shreveport, Caddo Parish, LA

Induction of NEIL1 and NEIL2 DNA glycosylases in aniline-induced splenic toxicity

PubMed Central

Ma, Huaxian; Wang, Jianling; Abdel-Rahman, Sherif Z.; Hazra, Tapas K.; Boor, Paul J.; Khan, M. Firoze

2011-01-01

The mechanisms by which aniline exposure elicits splenotoxic response, especially the tumorigenic response, are not well-understood. Earlier, we have shown that aniline-induced oxidative stress is associated with increased oxidative DNA damage in rat spleen. The base excision repair (BER) pathway is the major mechanism for the repair of oxidative DNA base lesions, and we have shown an up-regulation of 8-oxoguanine glycosylase 1 (OGG1), a specific DNA glycosylase involved in the removal of 8-hydroxy-2′-deoxyguanosine (8-OHdG) adducts, following aniline exposure. Nei-like DNA glycosylases (NEIL1/2) belong to a family of BER proteins that are distinct from other DNA glycosylases, including OGG1. However, contribution of NEIL1/2 in the repair of aniline-induced oxidative DNA damage in the spleen is not known. This study was, therefore, focused on evaluating if NEILs also contribute to the repair of oxidative DNA lesions in the spleen following aniline exposure. To achieve that, male SD rats were subchronically exposed to aniline (0.5 mmol/kg/day via drinking water for 30 days), while controls received drinking water only. The BER activity of NEIL1/2 was assayed using a bubble structure substrate containing 5-OHU (preferred substrates for NEIL1 and NEIL2) and by quantitating the cleavage products. Aniline treatment led to a 1.25-fold increase in the NEIL1/2-associated BER activity in the nuclear extracts of spleen compared to the controls. Real-time PCR analysis for NEIL1 and NEIL2 mRNA expression in the spleen revealed 2.7- and 3.9-fold increases, respectively, in aniline-treated rats compared to controls. Likewise, Western blot analysis showed that protein expression of NEIL1 and NEIL2 in the nuclear extract of spleens from aniline-treated rats was 2.0- and 3.8-fold higher than controls, respectively. Aniline treatment also led to stronger immunoreactivity for NEIL1 and NEIL2 in the spleens, confined to the red pulp areas. These studies, thus, show that aniline-induced oxidative stress is associated with an induction of NEIL1/2. The increased NIELs-mediated BER activity is another indication of aniline-induced oxidative damage in the spleen and could constitute another important mechanism of removal of oxidative DNA lesions, especially in transcribed DNA following aniline insult. PMID:21145906

72. (Credit LSU) Aerator in settling basin south of McNeil ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

72. (Credit LSU) Aerator in settling basin south of McNeil Pumping Station c1907. (Louisiana State University in Shreveport Archives, post card collection) - McNeil Street Pumping Station, McNeil Street & Cross Bayou, Shreveport, Caddo Parish, LA

Loss of NEIL3 DNA glycosylase markedly increases replication associated double strand breaks and enhances sensitivity to ATR inhibitor in glioblastoma cells

PubMed Central

Klattenhoff, Alex W.; Thakur, Megha; Chu, Christopher S.; Ray, Debolina; Habib, Samy L.; Kidane, Dawit

2017-01-01

DNA endonuclease eight-like glycosylase 3 (NEIL3) is one of the DNA glycosylases that removes oxidized DNA base lesions from single-stranded DNA (ssDNA) and non-B DNA structures. Approximately seven percent of human tumors have an altered NEIL3 gene. However, the role of NEIL3 in replication-associated repair and its impact on modulating treatment response is not known. Here, we report that NEIL3 is localized at the DNA double-strand break (DSB) sites during oxidative DNA damage and replication stress. Loss of NEIL3 significantly increased spontaneous replication-associated DSBs and recruitment of replication protein A (RPA). In contrast, we observed a marked decrease in Rad51 on nascent DNA strands at the replication fork, suggesting that HR-dependent repair is compromised in NEIL3-deficient cells. Interestingly, NEIL3-deficient cells were sensitive to ataxia–telangiectasia and Rad3 related protein (ATR) inhibitor alone or in combination with PARP1 inhibitor. This study elucidates the mechanism by which NEIL3 is critical to overcome oxidative and replication-associated genotoxic stress. Our findings may have important clinical implications to utilize ATR and PARP1 inhibitors to enhance cytotoxicity in tumors that carry altered levels of NEIL3. PMID:29348879

RPA physically interacts with the human DNA glycosylase NEIL1 to regulate excision of oxidative DNA base damage in primer-template structures.

PubMed

Theriot, Corey A; Hegde, Muralidhar L; Hazra, Tapas K; Mitra, Sankar

2010-06-04

The human DNA glycosylase NEIL1, activated during the S-phase, has been shown to excise oxidized base lesions in single-strand DNA substrates. Furthermore, our previous work demonstrating functional interaction of NEIL1 with PCNA and flap endonuclease 1 (FEN1) suggested its involvement in replication-associated repair. Here we show interaction of NEIL1 with replication protein A (RPA), the heterotrimeric single-strand DNA binding protein that is essential for replication and other DNA transactions. The NEIL1 immunocomplex isolated from human cells contains RPA, and its abundance in the complex increases after exposure to oxidative stress. NEIL1 directly interacts with the large subunit of RPA (K(d) approximately 20 nM) via the common interacting interface (residues 312-349) in NEIL1's disordered C-terminal region. RPA inhibits the base excision activity of both wild-type NEIL1 (389 residues) and its C-terminal deletion CDelta78 mutant (lacking the interaction domain) for repairing 5-hydroxyuracil (5-OHU) in a primer-template structure mimicking the DNA replication fork. This inhibition is reduced when the damage is located near the primer-template junction. Contrarily, RPA moderately stimulates wild-type NEIL1 but not the CDelta78 mutant when 5-OHU is located within the duplex region. While NEIL1 is inhibited by both RPA and Escherichia coli single-strand DNA binding protein, only inhibition by RPA is relieved by PCNA. These results showing modulation of NEIL1's activity on single-stranded DNA substrate by RPA and PCNA support NEIL1's involvement in repairing the replicating genome. Copyright 2010 Elsevier B.V. All rights reserved.

Neil2-null Mice Accumulate Oxidized DNA Bases in the Transcriptionally Active Sequences of the Genome and Are Susceptible to Innate Inflammation.

PubMed

Chakraborty, Anirban; Wakamiya, Maki; Venkova-Canova, Tatiana; Pandita, Raj K; Aguilera-Aguirre, Leopoldo; Sarker, Altaf H; Singh, Dharmendra Kumar; Hosoki, Koa; Wood, Thomas G; Sharma, Gulshan; Cardenas, Victor; Sarkar, Partha S; Sur, Sanjiv; Pandita, Tej K; Boldogh, Istvan; Hazra, Tapas K

2015-10-09

Why mammalian cells possess multiple DNA glycosylases (DGs) with overlapping substrate ranges for repairing oxidatively damaged bases via the base excision repair (BER) pathway is a long-standing question. To determine the biological role of these DGs, null animal models have been generated. Here, we report the generation and characterization of mice lacking Neil2 (Nei-like 2). As in mice deficient in each of the other four oxidized base-specific DGs (OGG1, NTH1, NEIL1, and NEIL3), Neil2-null mice show no overt phenotype. However, middle-aged to old Neil2-null mice show the accumulation of oxidative genomic damage, mostly in the transcribed regions. Immuno-pulldown analysis from wild-type (WT) mouse tissue showed the association of NEIL2 with RNA polymerase II, along with Cockayne syndrome group B protein, TFIIH, and other BER proteins. Chromatin immunoprecipitation analysis from mouse tissue showed co-occupancy of NEIL2 and RNA polymerase II only on the transcribed genes, consistent with our earlier in vitro findings on NEIL2's role in transcription-coupled BER. This study provides the first in vivo evidence of genomic region-specific repair in mammals. Furthermore, telomere loss and genomic instability were observed at a higher frequency in embryonic fibroblasts from Neil2-null mice than from the WT. Moreover, Neil2-null mice are much more responsive to inflammatory agents than WT mice. Taken together, our results underscore the importance of NEIL2 in protecting mammals from the development of various pathologies that are linked to genomic instability and/or inflammation. NEIL2 is thus likely to play an important role in long term genomic maintenance, particularly in long-lived mammals such as humans. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

Maniac Talk - Neil Gehrels

NASA Image and Video Library

2015-09-29

Neil Gehrels Maniac Lecture, September 29, 2015 Astrophysicist Neil Gehrels presented a Maniac lecture entitled "Adventures in Astrophysics." Neil shared his passion and adventures in astrophysics, which traces back to his astronomer father, his physicist wife, a life-long career at NASA Goddard Space Flight Center and good mentors.

Neil Snyder | NREL

Science.gov Websites

Photo of Neil Snyder Neil Snyder Manager III-Program Management Research Neil.Snyder@nrel.gov management. He has chiefly focused on developing complex systems and his specific expertise is leadership. As has acquired familiarity level expertise in many technical fields including environmental management

15. (Credit JAM) Aerial view of the McNeil Street Station, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

15. (Credit JAM) Aerial view of the McNeil Street Station, date unknown, but comparatively recent. Note the new filter house to the left of the settling basins. - McNeil Street Pumping Station, McNeil Street & Cross Bayou, Shreveport, Caddo Parish, LA

KSC-2014-3241

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- Apollo astronauts and their families tour the astronaut crew quarters in the Operations and Checkout Building at NASA's Kennedy Space Center in Florida. Here, from left, Apollo 11 command module pilot Michael Collins, Apollo 8 and Apollo 13 crew member Jim Lovell, and Apollo 11 moonwalker Buzz Aldrin share a light moment. The tour followed a ceremony renaming the refurbished Operations and Checkout Building for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. Besides housing the crew quarters, the building's high bay is being used to support the agency's new Orion spacecraft and is the same spaceport facility where the Apollo 11 command/service module and lunar module were prepped for the first lunar landing mission in 1969. Orion is designed to take humans farther than they’ve ever gone before, serving as the exploration vehicle that will carry astronauts to deep space and sustain the crew during travel to destinations such as an asteroid or Mars. The visit of the former astronauts was part of NASA's 45th anniversary celebration of the moon landing. As the world watched, Neil Armstrong and Aldrin landed in the moon's Sea of Tranquility aboard the lunar module Eagle on July 20, 1969. Meanwhile, crewmate Collins orbited above in the command module Columbia. For more, visit http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission. Photo credit: NASA/Kim Shiflett

KSC-2014-3240

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- Apollo astronauts and their families tour the astronaut crew quarters in the Operations and Checkout Building at NASA's Kennedy Space Center in Florida. Here, from left, Apollo 11 astronaut Michael Collins, NASA Administrator Charles Bolden, and Apollo 8 and Apollo 13 crew member Jim Lovell share a light moment. The tour followed a ceremony renaming the refurbished Operations and Checkout Building for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. Besides housing the crew quarters, the building's high bay is being used to support the agency's new Orion spacecraft and is the same spaceport facility where the Apollo 11 command/service module and lunar module were prepped for the first lunar landing mission in 1969. Orion is designed to take humans farther than they’ve ever gone before, serving as the exploration vehicle that will carry astronauts to deep space and sustain the crew during travel to destinations such as an asteroid or Mars. The visit of the former astronauts was part of NASA's 45th anniversary celebration of the moon landing. As the world watched, Neil Armstrong and Aldrin landed in the moon's Sea of Tranquility aboard the lunar module Eagle on July 20, 1969. Meanwhile, crewmate Collins orbited above in the command module Columbia. For more, visit http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission. Photo credit: NASA/Kim Shiflett

9. (Credit CBF) The McNeil Street Station from the northwest, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. (Credit CBF) The McNeil Street Station from the northwest, March 1913. The low service pump room is on the right, the clear water well (installed c1900) and filter house are on the left. - McNeil Street Pumping Station, McNeil Street & Cross Bayou, Shreveport, Caddo Parish, LA

KSC-99pp0877

NASA Image and Video Library

1999-07-16

KENNEDY SPACE CENTER, FLA. -- During an anniversary banquet honoring the Apollo program team, the people who made the entire lunar landing program possible, former Apollo astronaut Gene Cernan relates a humorous comment while Wally Schirra (background) gestures behind him. Cernan, who flew on Apollo 10 and 17, was the last man to walk on the moon; Schirra flew on Apollo 7. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Other guests at the banquet were former Apollo astronauts are Neil A. Armstrong and Edwin "Buzz" Aldrin who flew on Apollo 11, the launch of the first moon landing, and Walt Cunningham, who also flew on Apollo 7

KSC-04PD-0791

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. -- Neil Yorio, a Dynamac scientist(left), explains the function of the KSC Space Life Sciences (SLS) Lab to a prestigious tour group: Florida Gov. Jeb Bush, left of center, and NASA Administrator Sean OKeefe, and his wife, Laura, at right. Others in the group included former astronaut Winston Scott, U.S. Mint Director Henrietta Holsman Fore, and Center Director Jim Kennedy. The new lab is a state-of- the-art facility built for ISS biotechnology research. It was developed as a partnership between NASA-KSC and the State of Florida. The tour followed the launching ceremony at the KSC Visitor Complex for the new Florida quarter issued by the U.S. Mint. The ceremony was emceed by Kennedy and included remarks by OKeefe, Bush, Fore and Deputy Secretary of the Treasury Samuel W. Bodman.

KSC-03PD-2644

NASA Technical Reports Server (NTRS)

2003-01-01

KENNEDY SPACE CENTER, FLA. Employees check out the new chamber facilities of the Space Life Sciences Lab (SLSL), formerly known as the Space Experiment Research and Processing Laboratory (SERPL). From left are Ray Wheeler, with NASA; Debbie Wells and Larry Burns, with Dynamac; A.O. Rule, president of Environmental Growth Chambers, Inc. (ECG); Neil Yorio, with Dynamac; and John Wiezchowski, with ECG. The SLSL is a state-of-the-art facility being built for ISS biotechnology research. Developed as a partnership between NASA-KSC and the State of Florida, NASAs life sciences contractor will be the primary tenant of the facility, leasing space to conduct flight experiment processing and NASA- sponsored research. About 20 percent of the facility will be available for use by Floridas university researchers through the Florida Space Research Institute.

Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity

PubMed Central

Massaad, Michel J.; Zhou, Jia; Tsuchimoto, Daisuke; Chou, Janet; Jabara, Haifa; Janssen, Erin; Glauzy, Salomé; Olson, Brennan G.; Morbach, Henner; Ohsumi, Toshiro K.; Schmitz, Klaus; Kane, Jennifer; Torisu, Kumiko; Chouery, Eliane; Megarbane, Andre; Kang, Peter B.; Al-Idrissi, Eman; Aldhekri, Hasan; Meffre, Eric; Mizui, Masayuki; Manis, John P.; Al-Herz, Waleed; Wallace, Susan S.; Geha, Raif S.

2016-01-01

Alterations in the apoptosis of immune cells have been associated with autoimmunity. Here, we have identified a homozygous missense mutation in the gene encoding the base excision repair enzyme Nei endonuclease VIII-like 3 (NEIL3) that abolished enzymatic activity in 3 siblings from a consanguineous family. The NEIL3 mutation was associated with fatal recurrent infections, severe autoimmunity, hypogammaglobulinemia, and impaired B cell function in these individuals. The same homozygous NEIL3 mutation was also identified in an asymptomatic individual who exhibited elevated levels of serum autoantibodies and defective peripheral B cell tolerance, but normal B cell function. Further analysis of the patients revealed an absence of LPS-responsive beige-like anchor (LRBA) protein expression, a known cause of immunodeficiency. We next examined the contribution of NEIL3 to the maintenance of self-tolerance in Neil3–/– mice. Although Neil3–/– mice displayed normal B cell function, they exhibited elevated serum levels of autoantibodies and developed nephritis following treatment with poly(I:C) to mimic microbial stimulation. In Neil3–/– mice, splenic T and B cells as well as germinal center B cells from Peyer’s patches showed marked increases in apoptosis and cell death, indicating the potential release of self-antigens that favor autoimmunity. These findings demonstrate that deficiency in NEIL3 is associated with increased lymphocyte apoptosis, autoantibodies, and predisposition to autoimmunity. PMID:27760045

Prereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins

PubMed Central

Hegde, Muralidhar L.; Hegde, Pavana M.; Bellot, Larry J.; Mandal, Santi M.; Hazra, Tapas K.; Li, Guo-Min; Boldogh, Istvan; Tomkinson, Alan E.; Mitra, Sankar

2013-01-01

Base oxidation by endogenous and environmentally induced reactive oxygen species preferentially occurs in replicating single-stranded templates in mammalian genomes, warranting prereplicative repair of the mutagenic base lesions. It is not clear how such lesions (which, unlike bulky adducts, do not block replication) are recognized for repair. Furthermore, strand breaks caused by base excision from ssDNA by DNA glycosylases, including Nei-like (NEIL) 1, would generate double-strand breaks during replication, which are not experimentally observed. NEIL1, whose deficiency causes a mutator phenotype and is activated during the S phase, is present in the DNA replication complex isolated from human cells, with enhanced association with DNA in S-phase cells and colocalization with replication foci containing DNA replication proteins. Furthermore, NEIL1 binds to 5-hydroxyuracil, the oxidative deamination product of C, in replication protein A-coated ssDNA template and inhibits DNA synthesis by DNA polymerase δ. We postulate that, upon encountering an oxidized base during replication, NEIL1 initiates prereplicative repair by acting as a “cowcatcher” and preventing nascent chain growth. Regression of the stalled replication fork, possibly mediated by annealing helicases, then allows lesion repair in the reannealed duplex. This model is supported by our observations that NEIL1, whose deficiency slows nascent chain growth in oxidatively stressed cells, is stimulated by replication proteins in vitro. Furthermore, deficiency of the closely related NEIL2 alone does not affect chain elongation, but combined NEIL1/2 deficiency further inhibits DNA replication. These results support a mechanism of NEIL1-mediated prereplicative repair of oxidized bases in the replicating strand, with NEIL2 providing a backup function. PMID:23898192

What motion is: William Neile and the laws of motion.

PubMed

Kemeny, Max

2017-07-01

In 1668-1669 William Neile and John Wallis engaged in a protracted correspondence regarding the nature of motion. Neile was unhappy with the laws of motion that had been established by the Royal Society in three papers published in 1668, deeming them not explanations of motion at all, but mere descriptions. Neile insisted that science could not be informative without a discussion of causes, meaning that Wallis's purely kinematic account of collision could not be complete. Wallis, however, did not consider Neile's objections to his work to be serious. Rather than engage in a discussion of the proper place of natural philosophy in science, Wallis decided to show how Neile's preferred treatment of motion lead to absurd conclusions. This dispute is offered as a case study of dispute resolution within the early Royal Society.

4. (Credit SHR) The McNeil Street Station in 1896, north ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. (Credit SHR) The McNeil Street Station in 1896, north elevation. Note the offset filter house on the left, added in 1889-1890 to house four Hyatt upward flow pressure filters. It is adjacent to the high service pump room. (From: Shreveport Times, May 20, 1896, Railroad and Souvenir Edition) - McNeil Street Pumping Station, McNeil Street & Cross Bayou, Shreveport, Caddo Parish, LA

Destabilization of the PCNA trimer mediated by its interaction with the NEIL1 DNA glycosylase

DOE Office of Scientific and Technical Information (OSTI.GOV)

Prakash, Aishwarya; Moharana, Kedar; Wallace, Susan S.

The base excision repair (BER) pathway repairs oxidized lesions in the DNA that result from reactive oxygen species generated in cells. If left unrepaired, these damaged DNA bases can disrupt cellular processes such as replication. NEIL1 is one of the 11 human DNA glycosylases that catalyze the first step of the BER pathway, i.e. recognition and excision of DNA lesions. NEIL1 interacts with essential replication proteins such as the ring-shaped homotrimeric proliferating cellular nuclear antigen (PCNA). We isolated a complex formed between NEIL1 and PCNA (±DNA) using size exclusion chromatography (SEC). This interaction was confirmed using native gel electrophoresis andmore » mass spectrometry. Stokes radii measured by SEC hinted that PCNA in complex with NEIL1 (±DNA) was no longer a trimer. Height measurements and images obtained by atomic force microscopy also demonstrated the dissociation of the PCNA homotrimer in the presence of NEIL1 and DNA, while small-angle X-ray scattering analysis confirmed the NEIL1 mediated PCNA trimer dissociation and formation of a 1:1:1 NEIL1-DNA-PCNA(monomer) complex. Furthermore, ab initio shape reconstruction provides insights into the solution structure of this previously unreported complex. Together, these data point to a potential mechanistic switch between replication and BER.« less

KSC-2014-3215

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- At the Kennedy Space Center in Florida, NASA Administrator Charles Bolden, left, presents Center Director Robert Cabana with an Apollo 11 patch that flew to the moon on the Apollo 11 mission and is signed by all three Apollo 11 astronauts. The patch will remain at Kennedy until the first human spaceflight to Mars, when it will fly once again. The presentation was made during a ceremony renaming the refurbished Operations and Checkout Building for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. The building's high bay, in which the ceremony was held, is being used to support the agency's new Orion spacecraft and is the same spaceport facility where the Apollo 11 command/service module and lunar module were prepped for the first lunar landing mission in 1969. Orion is designed to take humans farther than they’ve ever gone before, serving as the exploration vehicle that will carry astronauts to deep space and sustain the crew during travel to destinations such as an asteroid or Mars. The ceremony was part of NASA's 45th anniversary celebration of the Apollo 11 moon landing. As the world watched, Neil Armstrong and Buzz Aldrin landed in the moon's Sea of Tranquility on July 20, 1969, aboard the lunar module Eagle. Meanwhile, crewmate Michael Collins orbited above in the command module Columbia. For more, visit http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission. Photo credit: NASA/Kim Shiflett

KSC-2014-3238

NASA Image and Video Library

2014-07-21

CAPE CANAVERAL, Fla. -- Apollo astronauts and their families tour the astronaut crew quarters in the Operations and Checkout Building at NASA's Kennedy Space Center in Florida. The tour followed a ceremony renaming the refurbished Operations and Checkout Building for Apollo 11 astronaut Neil Armstrong, the first person to set foot on the moon. Here, Armstrong's grandchildren, Bryce and Lily, in front, make their way into the room. Center Director Robert Cabana talks with Apollo 8 and Apollo 13 crew member Jim Lovell, at left, as NASA Administrator Charles Bolden talks with other Armstrong family members, at right. Besides housing the crew quarters, the building's high bay is being used to support the agency's new Orion spacecraft and is the same spaceport facility where the Apollo 11 command/service module and lunar module were prepped for the first lunar landing mission in 1969. Orion is designed to take humans farther than they’ve ever gone before, serving as the exploration vehicle that will carry astronauts to deep space and sustain the crew during travel to destinations such as an asteroid or Mars. The ceremony was part of NASA's 45th anniversary celebration of the Apollo 11 moon landing. As the world watched, Neil Armstrong and Buzz Aldrin landed in the moon's Sea of Tranquility on July 20, 1969, aboard the lunar module Eagle. Meanwhile, crewmate Michael Collins orbited above in the command module Columbia. For more, visit http://www.nasa.gov/press/2014/july/nasa-honors-historic-first-moon-landing-eyes-first-mars-mission. Photo credit: NASA/Kim Shiflett

KSC-99pp0875

NASA Image and Video Library

1999-07-16

KENNEDY SPACE CENTER, FLA. -- NASA Administrator Daniel S. Goldin (right) addresses the audience at the Apollo 11 anniversary banquet honoring the Apollo team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex, with seating under an unused Saturn V rocket like those that powered the Apollo launches . This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Among the guests at the banquet were former Apollo astronauts are Neil A. Armstrong and Edwin "Buzz" Aldrin who flew on Apollo 11, the launch of the first moon landing; Gene Cernan, who flew on Apollo 10 and 17 and was the last man to walk on the moon; and Walt Cunningham, who flew on Apollo 7

KSC-2014-3634

NASA Image and Video Library

2014-08-22

CAPE CANAVERAL, Fla. – NASA astronauts tour the Neil Armstrong Operations and Checkout Building high bay at NASA's Kennedy Space Center in Florida, and view the Orion forward bay cover for Exploration Flight Test-1. From left, are Jack Fischer, Mark Vande Hei, Katie Rubins and Scott Tingle. At far right is Jules Schneider, Lockheed Martin senior manager. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted test flight of Orion is scheduled to launch in 2014 atop a United Launch Alliance Delta IV rocket and in 2018 on NASA’s Space Launch System rocket. For more information, visit www.nasa.gov/orion. Photo credit: Dimitri Gerondidakis

12. (Credit CBF) West end of McNeil Street Station in ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. (Credit CBF) West end of McNeil Street Station in November 1911. The settling basins are visible on the far right. In the foreground is a pile of filter sand and several barrels of chemicals (probably lime or alum). The box car is delivering chemicals to storage in the west wing of the station. - McNeil Street Pumping Station, McNeil Street & Cross Bayou, Shreveport, Caddo Parish, LA

The disordered C-terminal domain of human DNA glycosylase NEIL1 contributes to its stability via intramolecular interactions.

PubMed

Hegde, Muralidhar L; Tsutakawa, Susan E; Hegde, Pavana M; Holthauzen, Luis Marcelo F; Li, Jing; Oezguen, Numan; Hilser, Vincent J; Tainer, John A; Mitra, Sankar

2013-07-10

NEIL1 [Nei (endonuclease VIII)-like protein 1], one of the five mammalian DNA glycosylases that excise oxidized DNA base lesions in the human genome to initiate base excision repair, contains an intrinsically disordered C-terminal domain (CTD; ~100 residues), not conserved in its Escherichia coli prototype Nei. Although dispensable for NEIL1's lesion excision and AP lyase activities, this segment is required for efficient in vivo enzymatic activity and may provide an interaction interface for many of NEIL1's interactions with other base excision repair proteins. Here, we show that the CTD interacts with the folded domain in native NEIL1 containing 389 residues. The CTD is poised for local folding in an ordered structure that is induced in the purified fragment by osmolytes. Furthermore, deletion of the disordered tail lacking both Tyr and Trp residues causes a red shift in NEIL1's intrinsic Trp-specific fluorescence, indicating a more solvent-exposed environment for the Trp residues in the truncated protein, which also exhibits reduced stability compared to the native enzyme. These observations are consistent with stabilization of the native NEIL1 structure via intramolecular, mostly electrostatic, interactions that were disrupted by mutating a positively charged (Lys-rich) cluster of residues (amino acids 355-360) near the C-terminus. Small-angle X-ray scattering (SAXS) analysis confirms the flexibility and dynamic nature of NEIL1's CTD, a feature that may be critical to providing specificity for NEIL1's multiple, functional interactions. Copyright © 2013 Elsevier Ltd. All rights reserved.

5. (Credit LSU) The NcNeil Street Station from Douglas Island, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. (Credit LSU) The NcNeil Street Station from Douglas Island, across Cross Bayou, c1907. Note the enlarged wood-framed filter wing on the left; the coal shed on the right; and the low service auxiliary pump house on tracks on the incline on the bank leading down to Cross Bayou. From: Louisiana State University, Shreveport Archives post card collection) - McNeil Street Pumping Station, McNeil Street & Cross Bayou, Shreveport, Caddo Parish, LA

60. (Credit LSU) Hyatt pressure filters (originally installed c1890) in ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

60. (Credit LSU) Hyatt pressure filters (originally installed c1890) in filter wing of McNeil Station in 1904. (From: Shreveport Progressive League, Shreveport of To-Day, September 1904, p. 47) - McNeil Street Pumping Station, McNeil Street & Cross Bayou, Shreveport, Caddo Parish, LA

NEIL1 protects against aflatoxin-induced hepatocellular carcinoma in mice.

PubMed

Vartanian, Vladimir; Minko, Irina G; Chawanthayatham, Supawadee; Egner, Patricia A; Lin, Ying-Chih; Earley, Lauriel F; Makar, Rosemary; Eng, Jennifer R; Camp, Matthew T; Li, Liang; Stone, Michael P; Lasarev, Michael R; Groopman, John D; Croy, Robert G; Essigmann, John M; McCullough, Amanda K; Lloyd, R Stephen

2017-04-18

Global distribution of hepatocellular carcinomas (HCCs) is dominated by its incidence in developing countries, accounting for >700,000 estimated deaths per year, with dietary exposures to aflatoxin (AFB 1 ) and subsequent DNA adduct formation being a significant driver. Genetic variants that increase individual susceptibility to AFB 1 -induced HCCs are poorly understood. Herein, it is shown that the DNA base excision repair (BER) enzyme, DNA glycosylase NEIL1, efficiently recognizes and excises the highly mutagenic imidazole ring-opened AFB 1 -deoxyguanosine adduct (AFB 1 -Fapy-dG). Consistent with this in vitro result, newborn mice injected with AFB 1 show significant increases in the levels of AFB 1 -Fapy-dG in Neil1 -/- vs. wild-type liver DNA. Further, Neil1 -/- mice are highly susceptible to AFB 1 -induced HCCs relative to WT controls, with both the frequency and average size of hepatocellular carcinomas being elevated in Neil1 -/- The magnitude of this effect in Neil1 -/- mice is greater than that previously measured in Xeroderma pigmentosum complementation group A (XPA) mice that are deficient in nucleotide excision repair (NER). Given that several human polymorphic variants of NEIL1 are catalytically inactive for their DNA glycosylase activity, these deficiencies may increase susceptibility to AFB 1 -associated HCCs.

KSC-2011-5962

NASA Image and Video Library

2011-07-25

CAPE CANAVERAL, Fla. -- The Apollo/Saturn V Center at NASA's Kennedy Space Center in Florida hosted a celebration on the 40th anniversary of NASA's Apollo 15 mission. Apollo 15 Commander Dave Scott and Command Module Pilot Al Worden and an elite gathering of Apollo-era astronauts were on hand for the event and panel discussion. Here, Apollo 11 Commander Neil Armstrong speaks to the invited guests. In the background is a model of the Lunar Module, part of the lander portion of the Apollo spacecraft. Worden circled the moon while Scott and the late Jim Irwin, the Lunar Module commander, made history when they became the first humans to drive a vehicle on the surface of the moon. They also provided extensive descriptions and photographic documentation of geologic features in the vicinity of the Hadley Rille landing site during their three days on the lunar surface. Photo credit: NASA/Kim Shiflett

KSC-04PD-0789

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. -- Neil Yorio, a Dynamac scientist (right), explains the function of the KSC Space Life Sciences (SLS) Lab to a prestigious tour group. From left are NASA Administrator Sean OKeefe and his wife, Laura; Florida Gov. Jeb Bush; Bernadette Kennedy, wife of the Center Director (CD); Columba Bush, wife of the governor; behind Mrs. Bush, former astronaut Winston Scott; and third from right, CD Jim Kennedy. The new lab is a state-of-the-art facility built for ISS biotechnology research. It was developed as a partnership between NASA-KSC and the State of Florida. The tour followed the launching ceremony at the KSC Visitor Complex for the new Florida quarter issued by the U.S. Mint. The ceremony was emceed by Kennedy and included remarks by OKeefe, Bush, U.S. Mint Director Henrietta Holsman Fore and Deputy Secretary of the Treasury Samuel W. Bodman.

KSC-04PD-0790

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. -- Neil Yorio, a Dynamac scientist(left), explains the function of the KSC Space Life Sciences (SLS) Lab to a prestigious tour group. In the background at left is former astronaut Winston Scott; at center is Bernadette Kennedy, wife of the Center Director (CD); next to her are Columba and Florida Gov. Jeb Bush; third from right is NASA Administrator Sean OKeefe, next to his wife, Laura; and on the far right is U.S. Mint Director Henrietta Holsman Fore. The new lab is a state-of-the-art facility built for ISS biotechnology research. It was developed as a partnership between NASA-KSC and the State of Florida. The tour followed the launching ceremony at the KSC Visitor Complex for the new Florida quarter issued by the U.S. Mint. The ceremony was emceed by CD Jim Kennedy and included remarks by OKeefe, Bush, Fore and Deputy Secretary of the Treasury Samuel W. Bodman.

"My World" with Neil Cavuto

ERIC Educational Resources Information Center

Valenzano, Joseph, Jr.

2006-01-01

This article profiles Neil Cavuto, the host of "Your World with Neil Cavuto," who never seems to miss a beat as the poised and impeccably dressed TV journalist who delivers the latest business news, conducts guest interviews, and offers personal commentary. But this 47-year-old newsman has battled not only one, but two life-altering medical…

Neil Armstrong Family Memorial Service

NASA Image and Video Library

2012-08-31

Eric "Rick" Armstrong, son of Neil Armstrong, speaks during a memorial service celebrating the life of his father, Friday, Aug. 31, 2012, at the Camargo Club in Cincinnati. Neil Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Bill Ingalls)

Neil Armstrong Family Memorial Service

NASA Image and Video Library

2012-08-31

Mark Armstrong, son of Neil Armstrong, speaks during a memorial service celebrating the life of his father, Friday, Aug. 31, 2012, at the Camargo Club in Cincinnati. Neil Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Bill Ingalls)

14. (Credit CBF) The McNeil Street Pumping Station c1926, after ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. (Credit CBF) The McNeil Street Pumping Station c1926, after substantial enlargement, from the front of the new combination main high service-low service pumping room. On the left, located over the old clear water well, is a circular building which housed both the laboratory and the chlorination room (it was added c1911). The tank above the lab-chlorination room is the filter wash water tank (new). From: South-West Waterworks Association Convention, Shreveport, Louisiana, October 1926, Souvenir Booklet, p.19) - McNeil Street Pumping Station, McNeil Street & Cross Bayou, Shreveport, Caddo Parish, LA

The Human DNA glycosylases NEIL1 and NEIL3 Excise Psoralen-Induced DNA-DNA Cross-Links in a Four-Stranded DNA Structure.

PubMed

Martin, Peter R; Couvé, Sophie; Zutterling, Caroline; Albelazi, Mustafa S; Groisman, Regina; Matkarimov, Bakhyt T; Parsons, Jason L; Elder, Rhoderick H; Saparbaev, Murat K

2017-12-12

Interstrand cross-links (ICLs) are highly cytotoxic DNA lesions that block DNA replication and transcription by preventing strand separation. Previously, we demonstrated that the bacterial and human DNA glycosylases Nei and NEIL1 excise unhooked psoralen-derived ICLs in three-stranded DNA via hydrolysis of the glycosidic bond between the crosslinked base and deoxyribose sugar. Furthermore, NEIL3 from Xenopus laevis has been shown to cleave psoralen- and abasic site-induced ICLs in Xenopus egg extracts. Here we report that human NEIL3 cleaves psoralen-induced DNA-DNA cross-links in three-stranded and four-stranded DNA substrates to generate unhooked DNA fragments containing either an abasic site or a psoralen-thymine monoadduct. Furthermore, while Nei and NEIL1 also cleave a psoralen-induced four-stranded DNA substrate to generate two unhooked DNA duplexes with a nick, NEIL3 targets both DNA strands in the ICL without generating single-strand breaks. The DNA substrate specificities of these Nei-like enzymes imply the occurrence of long uninterrupted three- and four-stranded crosslinked DNA-DNA structures that may originate in vivo from DNA replication fork bypass of an ICL. In conclusion, the Nei-like DNA glycosylases unhook psoralen-derived ICLs in various DNA structures via a genuine repair mechanism in which complex DNA lesions can be removed without generation of highly toxic double-strand breaks.

The NEIL1 G83D germline DNA glycosylase variant induces genomic instability and cellular transformation

PubMed Central

Galick, Heather A.; Marsden, Carolyn G.; Kathe, Scott; Dragon, Julie A.; Volk, Lindsay; Nemec, Antonia A.; Wallace, Susan S.; Prakash, Aishwarya; Doublié, Sylvie; Sweasy, Joann B.

2017-01-01

Base excision repair (BER) is a key genome maintenance pathway. The NEIL1 DNA glycosylase recognizes oxidized bases, and likely removes damage in advance of the replication fork. The rs5745906 SNP of the NEIL1 gene is a rare human germline variant that encodes the NEIL1 G83D protein, which is devoid of DNA glycosylase activity. Here we show that expression of G83D NEIL1 in MCF10A immortalized but non-transformed mammary epithelial cells leads to replication fork stress. Upon treatment with hydrogen peroxide, we observe increased levels of stalled replication forks in cells expressing G83D NEIL1 versus cells expressing the wild-type (WT) protein. Double-strand breaks (DSBs) arise in G83D-expressing cells during the S and G2/M phases of the cell cycle. Interestingly, these breaks result in genomic instability in the form of high levels of chromosomal aberrations and micronuclei. Cells expressing G83D also grow in an anchorage independent manner, suggesting that the genomic instability results in a carcinogenic phenotype. Our results are consistent with the idea that an inability to remove oxidative damage in an efficient manner at the replication fork leads to genomic instability and mutagenesis. We suggest that individuals who harbor the G83D NEIL1 variant face an increased risk for human cancer. PMID:29156764

76 FR 27669 - Automotive Components Holdings, LLC, a Subsidiary of Ford Motor Company, Saline Plant Division...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-12

... Were Reported Under Ford Company, Visteon, MSX International, W.J. O'Neil Company, and Unibar, Saline... workers whose wages were reported under Ford Company, Visteon, MSX International, W.J. O'Neil Company, and... under Ford Company, Visteon, MSX International, W.J. O'Neil Company, and Unibar, meet the certification...

Why We Need Neil Simon's Lost in Yonkers

ERIC Educational Resources Information Center

Coates, Nathan

2005-01-01

Nathan Coates, a high school teacher, describes the necessity of comedy in classrooms and also offers many points of discussion for approaching Neil Simon's play. Neil Simon's "Lost in Yonkers", which has won the Tony Award for the best play and the Pulitzer Award, both in 1991, tackles the toughest problems with the delicacy of a…

Neil Armstrong Family Memorial Service

NASA Image and Video Library

2012-08-31

Piper Van Wagenen, one of Neil Armstrong's 10 grandchildren, is seen during preparation of a memorial service celebrating the life of Neil Armstrong, Friday, Aug. 31, 2012, at the Camargo Club in Cincinnati. Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Bill Ingalls)

Threatened fishes of the world: Alosa alabamae (Jordan and Evermann, 1896) (Clupeidae)

Treesearch

Dwayne W. Meadows; Susan B. Adams; Jacob F. Schaefer

2007-01-01

River drainage to the Suwannee River, Florida (Mettee and O'Neil 2003); extirpated from at least 8 of the 14 native states (Mettee and O'Neil 2003). Abundance: Once commercially harvested, now rare (Mettee and O'Neil 2003); largest remaining population occurs in the Apalachicola River, Florida (Barku-100 et a!. 1993). Habitat...

Neil Armstrong Family Memorial Service

NASA Image and Video Library

2012-08-31

Carol Armstrong, wife of Neil Armstrong, and Piper Van Wagenen, one of 10 grandchildren, are seen during a memorial service celebrating the life of Neil Armstrong, Friday, Aug. 31, 2012, at the Camargo Club in Cincinnati. Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Bill Ingalls)

51. (Credit JTL) Interior view (looking NW) of new pumping ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

51. (Credit JTL) Interior view (looking NW) of new pumping room built in 1921. In the right foreground is #1 low service pump built in 1897. Installed at McNeil in 1898, it was not moved during the building of this room in 1921. Beyond is a 5 mgd capacity Worthington-Snow cross-compound, duplex crank-and-fly-wheel engine built in 1920. Behind the worthington is an 8 mgd Allis-Chalmers engine of the same configuration. it was built in 1911, but not installed at McNeil until 1927. Both engines have condensers. - McNeil Street Pumping Station, McNeil Street & Cross Bayou, Shreveport, Caddo Parish, LA

Neil Armstrong at Lunar Landing Research Facility

NASA Image and Video Library

1969-02-12

Neil Armstrong with the Lunar Excursion Module (LEM). Caption: "Not long after this photo was taken in front of the Lunar Landing Research Facility, astronaut Neil Armstrong became the first human to step upon the surface of the Moon." Photograph published in Winds of Change, 75th Anniversary NASA publication, by James Schultz, page 91. Also published in " A Century at Langley" by Joseph Chambers, pg. 95

Advantage of the modified Lunn-McNeil technique over Kalbfleisch-Prentice technique in competing risks

NASA Astrophysics Data System (ADS)

Lukman, Iing; Ibrahim, Noor A.; Daud, Isa B.; Maarof, Fauziah; Hassan, Mohd N.

2002-03-01

Survival analysis algorithm is often applied in the data mining process. Cox regression is one of the survival analysis tools that has been used in many areas, and it can be used to analyze the failure times of aircraft crashed. Another survival analysis tool is the competing risks where we have more than one cause of failure acting simultaneously. Lunn-McNeil analyzed the competing risks in the survival model using Cox regression with censored data. The modified Lunn-McNeil technique is a simplify of the Lunn-McNeil technique. The Kalbfleisch-Prentice technique is involving fitting models separately from each type of failure, treating other failure types as censored. To compare the two techniques, (the modified Lunn-McNeil and Kalbfleisch-Prentice) a simulation study was performed. Samples with various sizes and censoring percentages were generated and fitted using both techniques. The study was conducted by comparing the inference of models, using Root Mean Square Error (RMSE), the power tests, and the Schoenfeld residual analysis. The power tests in this study were likelihood ratio test, Rao-score test, and Wald statistics. The Schoenfeld residual analysis was conducted to check the proportionality of the model through its covariates. The estimated parameters were computed for the cause-specific hazard situation. Results showed that the modified Lunn-McNeil technique was better than the Kalbfleisch-Prentice technique based on the RMSE measurement and Schoenfeld residual analysis. However, the Kalbfleisch-Prentice technique was better than the modified Lunn-McNeil technique based on power tests measurement.

Acquisition of wood fuel at the Joseph C. McNeil Generating Station

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kropelin, W.

1993-12-31

The Joseph C. McNeil Generating Station is the world`s largest single boiler, municipally-owned, wood-fired electrical generating plant. The 50 megawatt McNeil Station is located in Burlington, Vermont and is owned by several Vermont public and private electric utilities. The operator and majority owner is the City of Burlington Electric Department (BED). Wood fuel procurement for the McNeil Station has been conducted in an environmentally sensitive way. Harvesting is carried out in conformance with a comprehensive wood chip harvesting policy and monitored by professional foresters. Unpredictable levels of Station operation require rigid adherence to a wood storage plan that minimizes themore » risk of over heating and spontaneous combustion of stockpiled fuel.« less

Some Considerations in Developing Effective Messaging: The SUCCESs Framework and Military Influence Activities

DTIC Science & Technology

2011-01-01

Service-Level Agreement with RMC 2009-0302-SLA- PR10023 Contract Project Manager: Neil Chuka, 613-998-2332 PWGSC Contract Number: PWGSC Contract...Number: CSA: Neil Chuka, Defence Scientist, 613-998-2332 The scientific or technical validity of this Contract Report is entirely the responsibility of...Counter-Insurgency Operations B-GL-323-004/FP-003, 13 December 2008, p.8-1. 3 Neil Chuka, “Future CF Influence Activities Capabilities,” DRDC CORA Letter

Moral Guardianship: Building Authentic Transformational Leaders; A Professional Military Educational Approach

DTIC Science & Technology

2012-02-15

understanding Neil Postman’s contemporary warnings in his book, Technopoly.43, 44 What makes these books relevant is all four books provide and...1998), 21-24. 20. Neil Turnbull, Get a Grip on Philosophy (New York, NY: Metro Books, 1999), 59. 21. Erik Thompson, “How to Be a Better Mentor...Encyclopedia, http://en.wikipedia.org/w/index.php?title=Novum_Organum&oldid=450281838 (accessed 19 September 2011). 44. Neil Postman, Technopoly: The

Radiotelemetry to estimate stream life of adult chum salmon in the McNeil River, Alaska

USGS Publications Warehouse

Peirce, Joshua M.; Otis, Edward O.; Wipfli, Mark S.; Follmann, Erich H.

2011-01-01

Estimating salmon escapement is one of the fundamental steps in managing salmon populations. The area-under-the-curve (AUC) method is commonly used to convert periodic aerial survey counts into annual salmon escapement indices. The AUC requires obtaining accurate estimates of stream life (SL) for target species. Traditional methods for estimating SL (e.g., mark–recapture) are not feasible for many populations. Our objective in this study was to determine the average SL of chum salmon Oncorhynchus keta in the McNeil River, Alaska, through radiotelemetry. During the 2005 and 2006 runs, 155 chum salmon were fitted with mortality-indicating radio tags as they entered the McNeil River and tracked until they died. A combination of remote data loggers, aerial surveys, and foot surveys were used to determine the location of fish and provide an estimate of time of death. Higher predation resulted in tagged fish below McNeil Falls having a significantly shorter SL (12.6 d) than those above (21.9 d). The streamwide average SL (13.8 d) for chum salmon at the McNeil River was lower than the regionwide value (17.5 d) previously used to generate AUC indices of chum salmon escapement for the McNeil River. We conclude that radiotelemetry is an effective tool for estimating SL in rivers not well suited to other methods.

KSC-69PC-413

NASA Image and Video Library

1969-07-16

KENNEDY SPACE CENTER, FLA. - The Apollo 11 Saturn V space vehicle climbs toward orbit after liftoff from Pad 39A at 9:32 a.m. EDT. In two-and-a-half minutes of powered flight, the S-IC booster lifts the vehicle to an altitude of about 39 miles approximately 55 miles downrange. This photo was taken with a 70-mm telescopic camera mounted in an Air force EC-135N plane. Onboard are astronauts Neil A. Armstrong, Michael Collins and Edwin E. Aldrin Jr. During the planned eight-day mission, Armstrong and Aldrin will descend in a Lunar Module (LM) to the Moon's surface while Collins orbits overhead in the Command Module. The two astronauts are to spend 22 hours on the Moon, including two-and-one-half hours outside the LM. They will gather samples of lunar material and will deploy scientific experiments that will transmit data about the lunar environment. They will rejoin Collins in the Command Module for the return trip to Earth.

KSC-2014-4197

NASA Image and Video Library

2014-08-19

CAPE CANAVERAL, Fla. – Inside the Neil Armstrong Operations and Checkout Building high bay at NASA’s Kennedy Space Center in Florida, Lockheed Martin technicians prepare to do a fit check of the forward bay cover for the Orion crew module. The cover is a shell that fits over Orion's crew module to protect the spacecraft during launch, orbital flight and re-entry into Earth's atmosphere. When Orion returns from space, the cover must be jettisoned high above the ground so that the parachutes can deploy and unfurl. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted flight test of Orion is scheduled to launch in December 2014 atop a United Launch Alliance Delta IV Heavy rocket and in 2018 on NASA’s Space Launch System rocket. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Daniel Casper

KSC-2014-4198

NASA Image and Video Library

2014-08-19

CAPE CANAVERAL, Fla. – Inside the Neil Armstrong Operations and Checkout Building high bay at NASA’s Kennedy Space Center in Florida, Lockheed Martin technicians prepare to do a fit check of the forward bay cover for the Orion crew module. The cover is a shell that fits over Orion's crew module to protect the spacecraft during launch, orbital flight and re-entry into Earth's atmosphere. When Orion returns from space, the cover must be jettisoned high above the ground so that the parachutes can deploy and unfurl. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted flight test of Orion is scheduled to launch in December 2014 atop a United Launch Alliance Delta IV Heavy rocket and in 2018 on NASA’s Space Launch System rocket. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Daniel Casper

KSC-2014-4199

NASA Image and Video Library

2014-08-19

CAPE CANAVERAL, Fla. – Inside the Neil Armstrong Operations and Checkout Building high bay at NASA’s Kennedy Space Center in Florida, Lockheed Martin technicians prepare to do a fit check of the forward bay cover for the Orion crew module. The cover is a shell that fits over Orion's crew module to protect the spacecraft during launch, orbital flight and re-entry into Earth's atmosphere. When Orion returns from space, the cover must be jettisoned high above the ground so that the parachutes can deploy and unfurl. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted flight test of Orion is scheduled to launch in December 2014 atop a United Launch Alliance Delta IV Heavy rocket and in 2018 on NASA’s Space Launch System rocket. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Daniel Casper

Neil Armstrong chats with attendees at Apollo 11 anniversary banquet.

NASA Technical Reports Server (NTRS)

1999-01-01

Former Apollo 11 astronaut Neil A. Armstrong talks with a former Apollo team member during an anniversary banquet honoring the Apollo team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Neil Armstrong was the first man to set foot on the moon.

Neil Armstrong chats with attendees at Apollo 11 anniversary banquet.

NASA Technical Reports Server (NTRS)

1999-01-01

Former Apollo 11 astronaut Neil A. Armstrong poses for a photograph with fans who attended the anniversary banquet honoring the Apollo team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Neil Armstrong was the first man to set foot on the moon.

77 FR 53137 - Death of Neil Armstrong

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-30

... Vol. 77 Thursday, No. 169 August 30, 2012 Part VII The President Proclamation 8849--Death of Neil Armstrong #0; #0; #0; Presidential Documents #0; #0; #0;#0;Federal Register / Vol. 77 , No. 169 / Thursday...

65. (Credit JTL) Filter room looking WSW across remodelled New ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

65. (Credit JTL) Filter room looking WSW across remodelled New York horizontal pressure filters (in foreground). - McNeil Street Pumping Station, McNeil Street & Cross Bayou, Shreveport, Caddo Parish, LA

Wings of Man Neil Armstrong Documentary

NASA Image and Video Library

2018-05-10

A narrated film documentary of Neil Armstrong, showing him in various aircraft, the Flight Research Center, lunar lander training vehicle (LLTV) at the Marshal Space Flight Center, Gemini VIII, in Apollo 11 and landing on the moon.

Identification, Characterization and Clinical Development of the New Generation of Breast Cancer Susceptibility Alleles

DTIC Science & Technology

2011-03-01

Neil M Walker2, Nicholas A Watkins8,9, Thilo Winzer8, John A Todd2, Willem H Ouwehand8,9 1958 Birth Cohort Controls: Richard W Jones18, Wendy L...Sarah Nutland2, Helen E Stevens2, Neil M Walker2, Barry Widmer2,41, John A Todd2 Type 2 Diabetes (Exeter): Timothy M Frayling42,43, Rachel M...Ravindrarajah5, Pamela Whittaker5, Claire Widden5, David Withers5, Panos Deloukas5; (Cambridge): Hin Tak Leung2, Sarah Nutland2, Helen E Stevens2, Neil M

98. (Credit BLV) Detail of gravity, flow conduit intake at ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

98. (Credit BLV) Detail of gravity, flow conduit intake at cross Lake dam Cribbing supports extra suction intake installed in 1930. - McNeil Street Pumping Station, McNeil Street & Cross Bayou, Shreveport, Caddo Parish, LA

50. (Credit JTL) Locomotivetype steam driven air compressor built by ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

50. (Credit JTL) Locomotive-type steam driven air compressor built by Westinghouse Air Brake Company and located on west wall of old high service room. - McNeil Street Pumping Station, McNeil Street & Cross Bayou, Shreveport, Caddo Parish, LA

66. (Credit JTL) Filter rooms looking south from end of ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

66. (Credit JTL) Filter rooms looking south from end of 1924 wing extension. Concrete gravity filters are in foreground, converted New York filters in background. - McNeil Street Pumping Station, McNeil Street & Cross Bayou, Shreveport, Caddo Parish, LA

Astronaut Neil Armstrong - Rock Sample Study - Geological Field Trip - TX

NASA Image and Video Library

1969-03-03

S69-25198 (25 Feb. 1969) --- Astronaut Neil A. Armstrong, commander of the Apollo 11 prime crew, studies rock sample during a geological field trip to the Quitman Mountains area near the Fort Quitman ruins in far west Texas.

88. (Credit CBF) Twelve Mile Bayou Pumping Station and force ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

88. (Credit CBF) Twelve Mile Bayou Pumping Station and force main for pumping water over levee and into the canal (Blind Bayou), March 1913. - McNeil Street Pumping Station, McNeil Street & Cross Bayou, Shreveport, Caddo Parish, LA

Neil Armstrong chats with attendees at Apollo 11 anniversary banquet.

NASA Technical Reports Server (NTRS)

1999-01-01

Former Apollo 11 astronaut Neil A. Armstrong is the center of attention at the anniversary banquet honoring the Apollo team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Neil Armstrong was the first man to set foot on the moon. He appeared at the banquet with other former astronauts Edwin 'Buzz' Aldrin, Gene Cernan, Walt Cunningham and others.

Neil Armstrong gets round of applaus at Apollo 11 anniversary banquet.

NASA Technical Reports Server (NTRS)

1999-01-01

Former Apollo 11 astronaut Neil A. Armstrong stands to a round of applause after being introduced at the anniversary banquet honoring the Apollo team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Neil Armstrong was the first man to set foot on the moon. He appeared at the banquet with other former astronauts Edwin 'Buzz' Aldrin, Gene Cernan, Walt Cunningham and others.

Interactions between brown bears and chum salmon at McNeil River, Alaska

USGS Publications Warehouse

Peirce, Joshua M.; Otis, Edward O.; Wipfli, Mark S.; Follmann, Erich H.

2013-01-01

Predation on returning runs of adult salmon (Oncorhynchus spp.) can have a large influence on their spawning success. At McNeil River State Game Sanctuary (MRSGS), Alaska, brown bears (Ursus arctos) congregate in high numbers annually along the lower McNeil River to prey upon returning adult chum salmon (O. keta). Low chum salmon escapements into McNeil River since the late 1990s have been proposed as a potential factor contributing to concurrent declines in bear numbers. The objective of this study was to determine the extent of bear predation on chum salmon in McNeil River, especially on pre-spawning fish, and use those data to adjust the escapement goal for the river. In 2005 and 2006, 105 chum salmon were radiotagged at the river mouth and tracked to determine cause and location of death. Below the falls, predators consumed 99% of tagged fish, killing 59% of them before they spawned. Subsequently, the escapement goal was nearly doubled to account for this pre-spawning mortality and to ensure enough salmon to sustain both predators and prey. This approach to integrated fish and wildlife management at MRSGS can serve as a model for other systems where current salmon escapement goals may not account for pre-spawning mortality.

Psoralen-induced DNA adducts are substrates for the base excision repair pathway in human cells

PubMed Central

Couvé-Privat, Sophie; Macé, Gaëtane; Saparbaev, Murat K.

2007-01-01

Interstrand cross-link (ICL) is a covalent modification of both strands of DNA, which prevents DNA strand separation during transcription and replication. Upon photoactivation 8-methoxypsoralen (8-MOP+UVA) alkylates both strands of DNA duplex at the 5,6-double bond of thymidines, generating monoadducts (MAs) and ICLs. It was thought that bulky DNA lesions such as MAs are eliminated only in the nucleotide excision repair pathway. Instead, non-bulky DNA lesions are substrates for DNA glycosylases and AP endonucleases which initiate the base excision repair (BER) pathway. Here we examined whether BER might be involved in the removal of psoralen–DNA photoadducts. The results show that in human cells DNA glycosylase NEIL1 excises the MAs in duplex DNA, subsequently the apurinic/apyrimidinic endonuclease 1, APE1, removes the 3′-phosphate residue at single-strand break generated by NEIL1. The apparent kinetic parameters suggest that NEIL1 excises MAs with high efficiency. Consistent with these results HeLa cells lacking APE1 and/or NEIL1 become hypersensitive to 8-MOP+UVA exposure. Furthermore, we demonstrate that bacterial homologues of NEIL1, the Fpg and Nei proteins, also excise MAs. New substrate specificity of the Fpg/Nei protein family provides an alternative repair pathway for ICLs and bulky DNA damage. PMID:17715144

Submarine Pressure Hull Collapse Considering Corrosion and Penetrations

DTIC Science & Technology

2010-11-01

Original signed by Liam Gannon Liam Gannon Defence Scientist Approved by Original signed by Neil Pegg Neil Pegg Head/Warship Performance Approved... Heath , D.C. (2001). Submarine Structural Analysis Suite, SubSAS Phase 1. (DREA TM 2001-025). Defence Research Establishment Atlantic. DRDC

86. (Credit CBF) Canal between Twelve Mile Bayou and Cross ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

86. (Credit CBF) Canal between Twelve Mile Bayou and Cross Bayou in the bed of Blind Bayou (constructed 1901-1903). Photo taken in November of 1911. - McNeil Street Pumping Station, McNeil Street & Cross Bayou, Shreveport, Caddo Parish, LA

69. (Credit JTL) View beneath marble meter bench showing hydraulic ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

69. (Credit JTL) View beneath marble meter bench showing hydraulic lines leading to water valve hydraulic control cylinders from control handles in bench; strings and pulleys activate meters. - McNeil Street Pumping Station, McNeil Street & Cross Bayou, Shreveport, Caddo Parish, LA

71. (Credit JTL) Pipe gallery looking south in basement underneath ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

71. (Credit JTL) Pipe gallery looking south in basement underneath 1910-11 and 1924 filter wing extensions. Note bottoms of converted New York horizontal pressure filters in right background. - McNeil Street Pumping Station, McNeil Street & Cross Bayou, Shreveport, Caddo Parish, LA

A Lean Approach to Scheduling Systems Engineering Resources

DTIC Science & Technology

2013-05-01

The CoS that have been identified for the heath care system KSS Network are presented in Table 1. The definition of initial WIP Limits, collaboration...Garry Roedler (Lockheed Martin), Karl Scotland (Rally Software, UK), Alan Shalloway (NetObjectives), Neil Shirk (Lockheed Martin), Neil Siegel

Efficient Dependency Computation for Dynamic Hybrid Bayesian Network in On-line System Health Management Applications

DTIC Science & Technology

2014-10-02

intervals (Neil, Tailor, Marquez, Fenton , & Hear, 2007). This is cumbersome, error prone and usually inaccurate. Even though a universal framework...Science. Neil, M., Tailor, M., Marquez, D., Fenton , N., & Hear. (2007). Inference in Bayesian networks using dynamic discretisation. Statistics

21. (Credit JTL) View looking NW at south elevations of ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

21. (Credit JTL) View looking NW at south elevations of boiler room, old high service pumping room (1887) and beginning of 1900 filter room addition; wash water tank (1926) in background. - McNeil Street Pumping Station, McNeil Street & Cross Bayou, Shreveport, Caddo Parish, LA

KSC-2014-3788

NASA Image and Video Library

2014-09-10

CAPE CANAVERAL, Fla. – Inside the Neil Armstrong Operations and Checkout Building high bay at NASA's Kennedy Space Center in Florida, members of the Brevard Police and Fire Pipes and Drums lead NASA and Lockheed Martin workers out of the high bay after a ceremony to turn over the Orion spacecraft for Exploration Flight Test-1 to Lockheed Martin Ground Operations from Orion Assembly, Integration and Production. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted test flight of the Orion is scheduled to launch atop a United Launch Alliance Delta IV Heavy rocket from Cape Canaveral Air Force Station in Florida in December to an altitude of 3,600 miles above the Earth's surface. The two-orbit, four-hour flight test will help engineers evaluate the systems critical to crew safety including the heat shield, parachute system and launch abort system. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Daniel Casper

KSC-2014-3784

NASA Image and Video Library

2014-09-10

CAPE CANAVERAL, Fla. – During a ceremony inside the Neil Armstrong Operations and Checkout Building high bay at NASA's Kennedy Space Center in Florida, Jules Schneider, Lockheed Martin Orion Production Operations manager, holds the key to symbolically turn over the Orion spacecraft for Exploration Flight Test-1 to Ground Operations. Waiting to accept the key is Blake Hale, Lockheed Martin Ground Operations manager. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted test flight of the Orion is scheduled to launch atop a United Launch Alliance Delta IV Heavy rocket from Cape Canaveral Air Force Station in Florida in December to an altitude of 3,600 miles above the Earth's surface. The two-orbit, four-hour flight test will help engineers evaluate the systems critical to crew safety including the heat shield, parachute system and launch abort system. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Daniel Casper

KSC-2014-3785

NASA Image and Video Library

2014-09-10

CAPE CANAVERAL, Fla. – During a ceremony inside the Neil Armstrong Operations and Checkout Building high bay at NASA's Kennedy Space Center in Florida, Jules Schneider, at right, Lockheed Martin Orion Production Operations manager, presents the key to symbolically turn over the Orion spacecraft for Exploration Flight Test-1 to Ground Operations. Accepting the key is Blake Hale, Lockheed Martin Ground Operations manager. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted test flight of the Orion is scheduled to launch atop a United Launch Alliance Delta IV Heavy rocket from Cape Canaveral Air Force Station in Florida in December to an altitude of 3,600 miles above the Earth's surface. The two-orbit, four-hour flight test will help engineers evaluate the systems critical to crew safety including the heat shield, parachute system and launch abort system. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Daniel Casper

KSC-2014-3783

NASA Image and Video Library

2014-09-10

CAPE CANAVERAL, Fla. – Inside the Neil Armstrong Operations and Checkout Building high bay at NASA's Kennedy Space Center in Florida, Jules Schneider, at right, Lockheed Martin Orion Production Operations manager, speaks to NASA and Lockheed Martin workers during a ceremony to turn over the Orion spacecraft for Exploration Flight Test-1 to Ground Operations. At left is Blake Hale, Lockheed Martin Ground Operations manager. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted test flight of the Orion is scheduled to launch atop a United Launch Alliance Delta IV Heavy rocket from Cape Canaveral Air Force Station in Florida in December to an altitude of 3,600 miles above the Earth's surface. The two-orbit, four-hour flight test will help engineers evaluate the systems critical to crew safety including the heat shield, parachute system and launch abort system. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Daniel Casper

KSC-2014-3786

NASA Image and Video Library

2014-09-10

CAPE CANAVERAL, Fla. – Inside the Neil Armstrong Operations and Checkout Building high bay at NASA's Kennedy Space Center in Florida, Jules Schneider, at right, Lockheed Martin Orion Production Operations manager, shakes hands with Blake Hale, Lockheed Martin Ground Operations manager, during a ceremony to officially turn over the Orion spacecraft for Exploration Flight Test-1 to Lockheed Martin Ground Operations. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted test flight of the Orion is scheduled to launch atop a United Launch Alliance Delta IV Heavy rocket from Cape Canaveral Air Force Station in Florida in December to an altitude of 3,600 miles above the Earth's surface. The two-orbit, four-hour flight test will help engineers evaluate the systems critical to crew safety including the heat shield, parachute system and launch abort system. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Daniel Casper

KSC-06pd0466

NASA Image and Video Library

2006-03-10

KENNEDY SPACE CENTER, FLA. - During the 2006 FIRST Robotics Regional Competition held March 9-11 at the University of Central Florida in Orlando, Kennedy Space Center Director Jim Kennedy greets members of one of the robotic teams. To the left of Kennedy is Neil Berger, the center director's intern; at right of Kennedy is Chris Fairey, retired NASA and Regional Planning Committee co-chair. The FIRST Robotics Competition challenges teams of young people and their mentors to solve a common problem in a six-week timeframe using a standard "kit of parts" and a common set of rules. Teams build robots from the parts and enter them in a series of competitions. FIRST, which is based on "For Inspiration and Recognition of Science and Technology," redefines winning for these students. Teams are rewarded for excellence in design, demonstrated team spirit, gracious professionalism and maturity, and ability to overcome obstacles. Scoring the most points is a secondary goal. Winning means building partnerships that last. NASA and the University of Central Florida are co-sponsors of the regional event, which this year included more than 50 teams. Photo credit: NASA/Kim Shiflett

KSC-2014-4200

NASA Image and Video Library

2014-08-19

CAPE CANAVERAL, Fla. – Inside the Neil Armstrong Operations and Checkout Building high bay at NASA’s Kennedy Space Center in Florida, Lockheed Martin technicians monitor the progress as a crane lifts the forward bay cover for a fit check on the Orion crew module. The cover is a shell that fits over Orion's crew module to protect the spacecraft during launch, orbital flight and re-entry into Earth's atmosphere. When Orion returns from space, the cover must be jettisoned high above the ground so that the parachutes can deploy and unfurl. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted flight test of Orion is scheduled to launch in December 2014 atop a United Launch Alliance Delta IV Heavy rocket and in 2018 on NASA’s Space Launch System rocket. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Daniel Casper

KSC-2014-3776

NASA Image and Video Library

2014-09-07

CAPE CANAVERAL, Fla. – Inside the Neil Armstrong Operations and Checkout Building high bay at NASA's Kennedy Space Center in Florida, the Orion crew and service module stack for Exploration Flight Test-1 was lifted by crane out of the test cell. The stack has been lowered onto the mating device. Technicians are attaching the stack to the mating device. A protective covering surrounds the crew module. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted test flight of the Orion is scheduled to launch later this year atop a Delta IV Heavy rocket from Cape Canaveral Air Force Station in Florida to an altitude of 3,600 miles above the Earth's surface. The two-orbit, four-hour flight test will help engineers evaluate the systems critical to crew safety including the heat shield, parachute system and launch abort system. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Ben Smegelsky

KSC-2014-3766

NASA Image and Video Library

2014-09-07

CAPE CANAVERAL, Fla. – Inside the Neil Armstrong Operations and Checkout Building high bay at NASA's Kennedy Space Center in Florida, a crane has lifted the Orion crew and service module stack for Exploration Flight Test-1 out of the test cell and is being transferred to a mating device. A protective covering surrounds the crew module. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted test flight of the Orion is scheduled to launch later this year atop a Delta IV Heavy rocket from Cape Canaveral Air Force Station in Florida to an altitude of 3,600 miles above the Earth's surface. The two-orbit, four-hour flight test will help engineers evaluate the systems critical to crew safety including the heat shield, parachute system and launch abort system. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Ben Smegelsky

KSC-2014-3773

NASA Image and Video Library

2014-09-07

CAPE CANAVERAL, Fla. – Inside the Neil Armstrong Operations and Checkout Building high bay at NASA's Kennedy Space Center in Florida, the Orion crew and service module stack for Exploration Flight Test-1 was lifted by crane out of the test cell and is being lowered onto a mating device A protective covering surrounds the crew module. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted test flight of the Orion is scheduled to launch later this year atop a Delta IV Heavy rocket from Cape Canaveral Air Force Station in Florida to an altitude of 3,600 miles above the Earth's surface. The two-orbit, four-hour flight test will help engineers evaluate the systems critical to crew safety including the heat shield, parachute system and launch abort system. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Ben Smegelsky

KSC-2014-4201

NASA Image and Video Library

2014-08-19

CAPE CANAVERAL, Fla. – Inside the Neil Armstrong Operations and Checkout Building high bay at NASA’s Kennedy Space Center in Florida, Lockheed Martin technicians on a work platform monitor the progress as a crane lowers the forward bay cover onto the Orion crew module for a fit check. The cover is a shell that fits over Orion's crew module to protect the spacecraft during launch, orbital flight and re-entry into Earth's atmosphere. When Orion returns from space, the cover must be jettisoned high above the ground so that the parachutes can deploy and unfurl. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted flight test of Orion is scheduled to launch in December 2014 atop a United Launch Alliance Delta IV Heavy rocket and in 2018 on NASA’s Space Launch System rocket. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Daniel Casper

Mentoring and supervision in healthcare Neil Gopee Mentoring and supervision in healthcare Sage 224 £19.99 978-1412930208 1412930200 [Formula: see text].

PubMed

2008-09-13

AUTHOR NEIL GOPEE explores the standards, competencies and outcomes for mentoring in health care. He reviews the current knowledge, skills and attitudes required of mentors, and successfully links these with research-based literature.

80. (Credit JTL) Filters added in 1947 and 1975 in ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

80. (Credit JTL) Filters added in 1947 and 1975 in foreground (south of 1942 filter building). Tops of fluorine tanks for new (1980) fluoridation system can barely be seen over left edge of filters. - McNeil Street Pumping Station, McNeil Street & Cross Bayou, Shreveport, Caddo Parish, LA

62. (Credit CBF) Operating floor of filter room, c1912. The ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

62. (Credit CBF) Operating floor of filter room, c1912. The remodeled New York horizontal pressure filters (now gravity filters) are in the foreground; the remodelled Hyatt tub filters are in the background. - McNeil Street Pumping Station, McNeil Street & Cross Bayou, Shreveport, Caddo Parish, LA

A Rhetoric of American Popular Drama: The Comedies of Neil Simon.

ERIC Educational Resources Information Center

McMahon, Helen

This paper discusses generally Neil Simon's plays; specifically examines "God's Favorite,""Plaza Suite,""Barefoot in The Park,""Star Spangled Girl,""Come Blow Your Horn," and "Last of the Red Hot Lovers"; and quotes reviews of the plays. An examination of the composition of the plays…

Contact/Disability Performance. An Essay Constructed between Petra Kuppers and Neil Marcus

ERIC Educational Resources Information Center

Kuppers, Petra; Marcus, Neil

2009-01-01

This dialogue discusses disability and performance through poetic interrogation, interspersed with segments of Neil Marcus's play "My Sexual History." The authors touch on such topics such as sexuality and representation, dance and theatre, the management of disability staring, speech difference and writing, curiosity and shrouding. (Contains 1…

Acceptance versus Change in Behavior Therapy: An Interview with Neil Jacobson.

ERIC Educational Resources Information Center

Hines, Max

1998-01-01

Neil Jacobson is a leader in research-based efforts to improve behavioral couples therapy. This interview focuses on his professional journey toward an integrative model, as well as his thoughts about the future directions of behavioral therapy and family counseling. The integrative-couples therapy model is described and discussed. (Author/EMK)

Charles L. Brewer Award for Distinguished Teaching of Psychology: Neil Lutsky

ERIC Educational Resources Information Center

American Psychologist, 2011

2011-01-01

The American Psychological Foundation (APF) Charles L. Brewer Award for Distinguished Teaching of Psychology recognizes an outstanding career contribution to the teaching of psychology. The 2011 recipient of the Distinguished Teaching Award is Neil Lutsky. Dorothy W. Cantor, president of the APF, will present the APF Distinguished Teaching Award…

Scoping Aerospace: Tracking Federal Procurement and R&D Spending in the Aerospace Sector

DTIC Science & Technology

2005-01-01

Hamre, William Schneider, Jr., Robert J. Stevens, Neil deGrasse Tyson , and Heidi R. Wood. 2 The results only approximate external spending because they...fire,6 the project achieved its primary goal when Apollo 11 successfully landed astronauts Neil Armstrong and Buzz Aldrin on the lunar surface in

68. (Credit JTL) Front view of one of the many ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

68. (Credit JTL) Front view of one of the many marble benches used in the filter rooms for housing meters and filter controls. These were built by F.R. Leopold, Inc. of Pittsburgh, PA and installed in 1924-26. - McNeil Street Pumping Station, McNeil Street & Cross Bayou, Shreveport, Caddo Parish, LA

63. (Credit JTL) Filter room looking east from doorway of ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

63. (Credit JTL) Filter room looking east from doorway of 1887 high service room. Remodelled Hyatt tub filters are in foreground; remodelled New York horizontal pressure filters are in background. These two sets of filters were retired in 1942. - McNeil Street Pumping Station, McNeil Street & Cross Bayou, Shreveport, Caddo Parish, LA

78. (Credit JTL) Mixing chambers (19241926) in foreground, looking west ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

78. (Credit JTL) Mixing chambers (1924-1926) in foreground, looking west along south facade of station. Settling basins to left, new filter house (1942) in background. Aerators added in 1930-31 to remove carbon dioxide from water. - McNeil Street Pumping Station, McNeil Street & Cross Bayou, Shreveport, Caddo Parish, LA

Neil Armstrong Family Memorial Service

NASA Image and Video Library

2012-08-31

Piper Van Wagenen, one of Neil Armstrong's 10 grandchildren, speaks during a memorial service celebrating the life of her grandfather, Friday, Aug. 31, 2012, at the Camargo Club in Cincinnati. Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Bill Ingalls)

Neil Armstrong Family Memorial Service

NASA Image and Video Library

2012-08-31

U.S. Sen. Rob Portman, R-Ohio, speaks during a memorial service celebrating the life of Neil Armstrong, Friday, Aug. 31, 2012, at the Camargo Club in Cincinnati. Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Bill Ingalls)

Neil Armstrong Family Memorial Service

NASA Image and Video Library

2012-08-31

Sen. John Glenn and his wife Annie listen during a memorial service celebrating the life of Neil Armstrong, Friday, Aug. 31, 2012, at the Camargo Club in Cincinnati. Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Bill Ingalls)

Neil Armstrong Family Memorial Service

NASA Image and Video Library

2012-08-31

A memorial tribute from the Smithsonian is seen at the entrance of a private memorial service celebrating the life of Neil Armstrong, Aug. 31, 2012, at the Camargo Club in Cincinnati. Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Bill Ingalls)

Neil Armstrong Family Memorial Service

NASA Image and Video Library

2012-08-31

Apollo 11 Astronauts Michael Collins, left, and Buzz Aldrin talk at a private memorial service celebrating the life of Neil Armstrong, Aug. 31, 2012, at the Camargo Club in Cincinnati. Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Bill Ingalls)

Neil Armstrong Family Memorial Service

NASA Image and Video Library

2012-08-31

The Hamilton Co. (OH) Sheriff’s Office bagpipe corps concludes the memorial service celebrating the life of Neil Armstrong, Friday, Aug. 31, 2012, at the Camargo Club in Cincinnati. Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Bill Ingalls)

Neil Armstrong Family Memorial Service

NASA Image and Video Library

2012-08-31

Businessman and friend of Neil Armstrong, Charles Mechem, speaks during a memorial service celebrating the life of Armstrong, Friday, Aug. 31, 2012, at the Camargo Club in Cincinnati. Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Bill Ingalls)

Differential effects of silver nanoparticles on DNA damage and DNA repair gene expression in Ogg1-deficient and wild type mice.

PubMed

Nallanthighal, Sameera; Chan, Cadia; Murray, Thomas M; Mosier, Aaron P; Cady, Nathaniel C; Reliene, Ramune

2017-10-01

Due to extensive use in consumer goods, it is important to understand the genotoxicity of silver nanoparticles (AgNPs) and identify susceptible populations. 8-Oxoguanine DNA glycosylase 1 (OGG1) excises 8-oxo-7,8-dihydro-2-deoxyguanine (8-oxoG), a pro-mutagenic lesion induced by oxidative stress. To understand whether defects in OGG1 is a possible genetic factor increasing an individual's susceptibly to AgNPs, we determined DNA damage, genome rearrangements, and expression of DNA repair genes in Ogg1-deficient and wild type mice exposed orally to 4 mg/kg of citrate-coated AgNPs over a period of 7 d. DNA damage was examined at 3 and 7 d of exposure and 7 and 14 d post-exposure. AgNPs induced 8-oxoG, double strand breaks (DSBs), chromosomal damage, and DNA deletions in both genotypes. However, 8-oxoG was induced earlier in Ogg1-deficient mice and 8-oxoG levels were higher after 7-d treatment and persisted longer after exposure termination. AgNPs downregulated DNA glycosylases Ogg1, Neil1, and Neil2 in wild type mice, but upregulated Myh, Neil1, and Neil2 glycosylases in Ogg1-deficient mice. Neil1 and Neil2 can repair 8-oxoG. Thus, AgNP-mediated downregulation of DNA glycosylases in wild type mice may contribute to genotoxicity, while upregulation thereof in Ogg1-deficient mice could serve as an adaptive response to AgNP-induced DNA damage. However, our data show that Ogg1 is indispensable for the efficient repair of AgNP-induced damage. In summary, citrate-coated AgNPs are genotoxic in both genotypes and Ogg1 deficiency exacerbates the effect. These data suggest that humans with genetic polymorphisms and mutations in OGG1 may have increased susceptibility to AgNP-mediated DNA damage.

An Eye for an I: Neil Gaiman's Coraline and Questions of Identity

ERIC Educational Resources Information Center

Rudd, David

2008-01-01

This paper sees Neil Gaiman's "Coraline" as following a darker tradition in children's literature, most commonly found in the fairy tale. It explores some of the existential issues that concern us all: to do with identity, sex, death, ontology, evil, desire and violence. The article takes a largely psychoanalytical approach, showing how Freud's…

30. (Credit JTL) Old 19111912 low service pump pit and ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

30. (Credit JTL) Old 1911-1912 low service pump pit and receiving well in background. Platform and well in foreground constructed in 1977 for #6 and #7 electric low service pumps (#6 pump moved from old receiving well; #7 installed new). - McNeil Street Pumping Station, McNeil Street & Cross Bayou, Shreveport, Caddo Parish, LA

Factors Affecting Career Decision-Making: Further Validation of the O'Neil Career-Sex Role Model and the Career Factor Checklist.

ERIC Educational Resources Information Center

Meinecke, Christine; O'Neil, James M.

Many correlates of vocational choice have been suggested by career development theorists. A career decision-making model developed by O'Neil, Meeker, and Borgers suggests six factors (individual, societal, familial, socioeconomic, situational, psychosocial-emotional) that affect both sex role socialization and career decision-making. The validity…

High Temperature Bonding Techniques for Solar Cell Array

DTIC Science & Technology

1977-11-01

Kedaya, E. , Kawakami, J. K., Kopf, P. W. , Kwiatkowski, G. T., McNeil, D. W. , and Tulis , R. W., "Union Carbide Rept. " UCRI-735 (30 July 1973...6. Peters, E. N., Kedaya, E., Kawakami, J. K. , Kwiatkowski, G. T. , McNeil, D. W., and Tulis , R. W., Rubber Chem. and Technol. 48 (1), 14-18 (1975

Neil Armstrong Family Memorial Service

NASA Image and Video Library

2012-08-31

A photograph of Neil Armstrong as a young man is displayed on a table during a memorial service celebrating the life of Armstrong, Friday, Aug. 31, 2012, at the Camargo Club in Cincinnati. Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Bill Ingalls)

Perception of Personal Well Being and Workers Compensation Injuries in Federal Correctional Workers

DTIC Science & Technology

2001-05-01

Casey Skvorc Department of Medical and Clinical Psychology Uniformed Services University of the Health Sciences...by Casey Skvorc Doctoral Dissertation Submitted to the Faculty of the Department of Medical ...as a medical psychologist. I am grateful especially to my Advisor, Dr. Neil E. Grunberg, for his direction. Neil and I “climbed a mountain”together

18. (Credit JTL) North side of plant, view looking south ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

18. (Credit JTL) North side of plant, view looking south along east side of 1921 pump room (at right) showing 1911 lab and chlorination building in foreground under wash water tank tower legs; filter wing, old high service room (1887), and side entrance in background. - McNeil Street Pumping Station, McNeil Street & Cross Bayou, Shreveport, Caddo Parish, LA

Strategy Of Attrition: Why General Westmoreland Failed In 1967

DTIC Science & Technology

2016-05-26

393-408; Neil Sheehan, A Bright Shining Lie: John Paul Vann and America in Vietnam (New York: Random House, 1988), 6. 1...March, James G, and Chip Heath . A Primer on Decision Making: How...Washington, DC: Office of Air Force History, 1988. Sheehan, Neil . A Bright Shining Lie: John Paul Vann and America in Vietnam. New York: Random House

53. (Credit JTL) Interior view looking southwest at two high ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

53. (Credit JTL) Interior view looking southwest at two high service engines with Worthington-Snow engine in foreground. Electric high service booster pump is located on the far right between the two high service pumping engines. Grating is immediate foreground covers # 3 low service pump pit. - McNeil Street Pumping Station, McNeil Street & Cross Bayou, Shreveport, Caddo Parish, LA

Neil Armstrong Family Memorial Service

NASA Image and Video Library

2012-08-31

Apollo 11 Astronauts Michael Collins, left, NASA Deputy Administrator Lori Garver and NASA Administrator Charles Bolden, right, talk at a private memorial service celebrating the life of Neil Armstrong, Aug. 31, 2012, at the Camargo Club in Cincinnati. Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Bill Ingalls)

Construing the Child Reader: A Cognitive Stylistic Analysis of the Opening to Neil Gaiman's "The Graveyard Book"

ERIC Educational Resources Information Center

Giovanelli, Marcello

2018-01-01

Neil Gaiman's "The Graveyard Book" (2009) charts the story of Nobody Owens, a boy who is adopted by supernatural entities in the local graveyard after his family is murdered. This article draws on the notion of the "construed reader," and combines two cognitive stylistic frameworks to analyse the opening section of the novel.…

Astronaut Neil Armstrong during thermovacuum training

NASA Image and Video Library

1969-05-07

Astronaut Neil A. Armstrong, commander of the Apollo 11 lunar landing mission, is photographed during thermovacuum training in Chamber B of the Space Environment Simulation Laboratory, Building 32, Manned Spacecraft Center. He is wearing an Extravehicular Mobility Unit. The training simulated lunar surface vacuum and thermal conditions during astronaut operations outside the Lunar Module on the moon's surface. The mirror was used to reflect solar light.

Neil Postman and the Critique of Technology (In Memory of Neil Postman Who Died on October 5, 2003)

ERIC Educational Resources Information Center

van der Laan, J. M.

2004-01-01

This (by no means exhaustive) survey of Postman's work reflects on his penetrating analyses of contemporary technology. He focused attention on the ways technology today, especially the television and the computer, inevitably change us. The essential questions he asks us to ask (and answer) are, How does technology affect us? Is it for good or…

NEIL2 Protects against Oxidative DNA Damage Induced by Sidestream Smoke in Human Cells

PubMed Central

Sarker, Altaf H.; Chatterjee, Arpita; Williams, Monique; Lin, Sabrina; Havel, Christopher; Jacob III, Peyton; Boldogh, Istvan; Hazra, Tapas K.; Talbot, Prudence; Hang, Bo

2014-01-01

Secondhand smoke (SHS) is a confirmed lung carcinogen that introduces thousands of toxic chemicals into the lungs. SHS contains chemicals that have been implicated in causing oxidative DNA damage in the airway epithelium. Although DNA repair is considered a key defensive mechanism against various environmental attacks, such as cigarette smoking, the associations of individual repair enzymes with susceptibility to lung cancer are largely unknown. This study investigated the role of NEIL2, a DNA glycosylase excising oxidative base lesions, in human lung cells treated with sidestream smoke (SSS), the main component of SHS. To do so, we generated NEIL2 knockdown cells using siRNA-technology and exposed them to SSS-laden medium. Representative SSS chemical compounds in the medium were analyzed by mass spectrometry. An increased production of reactive oxygen species (ROS) in SSS-exposed cells was detected through the fluorescent detection and the induction of HIF-1α. The long amplicon–quantitative PCR (LA-QPCR) assay detected significant dose-dependent increases of oxidative DNA damage in the HPRT gene of cultured human pulmonary fibroblasts (hPF) and BEAS-2B epithelial cells exposed to SSS for 24 h. These data suggest that SSS exposure increased oxidative stress, which could contribute to SSS-mediated toxicity. siRNA knockdown of NEIL2 in hPF and HEK 293 cells exposed to SSS for 24 h resulted in significantly more oxidative DNA damage in HPRT and POLB than in cells with control siRNA. Taken together, our data strongly suggest that decreased repair of oxidative DNA base lesions due to an impaired NEIL2 expression in non-smokers exposed to SSS would lead to accumulation of mutations in genomic DNA of lung cells over time, thus contributing to the onset of SSS-induced lung cancer. PMID:24595271

A NEIL1 single nucleotide polymorphism (rs4462560) predicts the risk of radiation-induced toxicities in esophageal cancer patients treated with definitive radiotherapy.

PubMed

Chen, Yun; Zhu, Meiling; Zhang, Zhen; Jiang, Guoliang; Fu, Xiaolong; Fan, Min; Sun, Menghong; Wei, Qingyi; Zhao, Kuaile

2013-12-01

To assess the association between single nucleotide polymorphisms (SNPs) of base-excision repair genes and clinical outcomes, the roles of genetic variants of 3 selected genes-flap structure-specific endonuclease 1 (FEN1), 8-hydroxyguanine DNA glycosylase (hOGG1), and nei endonuclease VIII-like 1 (NEIL1)--were investigated in radiation-induced esophageal toxicity (RIET), radiation pneumonitis (RP), and overall survival (OS) after radio(chemo)therapy in patients with esophageal squamous cell carcinoma (ESCC). NEIL1 reference SNP 4462560 (rs4462560) and rs7402844, hOGG1 rs1052133 and rs293795, and FEN1 rs4246215 and rs174538 were genotyped in 187 patients with ESCC who received definitive radiotherapy with or without chemotherapy. Kaplan-Meier cumulative probabilities and Cox proportional hazards regression models were used to assess the effect of the genotypes on the risk of RIET, RP, and OS. The authors observed that patients who had the NEIL1 rs4462560 GC/CC genotype had a statistically significantly lower risk of both grade ≥ 2 acute radiation-induced esophageal toxicity (RIET) (adjusted hazard ratio [HR], 0.421; 95% confidence interval [CI], 0.207-0.856; P = .017) and grade ≥ 2 acute radiation pneumonitis (RP) (adjusted HR, 0.392; 95% CI, 0.163-0.946; P = .037) compared with patients who had the GG genotype, but the genotype did not affect OS (adjusted HR, 0.778; 95% CI, 0.471-1.284; P = .326). There were no significant findings for other the SNPs under investigation. The NEIL1 rs4462560 SNP may serve as a predictor of acute RIET and RP risk but not of OS. Larger prospective studies are needed to validate these findings. © 2013 American Cancer Society.

KSC-2014-3781

NASA Image and Video Library

2014-09-10

CAPE CANAVERAL, Fla. – Inside the Neil Armstrong Operations and Checkout Building high bay at NASA's Kennedy Space Center in Florida, members of the Brevard Police and Fire Pipes and Drums lead NASA and Lockheed Martin workers toward the Orion crew module, stacked atop its service module. A ceremony will begin to officially turn over the Orion spacecraft for Exploration Flight Test-1 to Lockheed Martin Ground Operations from Orion Assembly, Integration and Production. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted test flight of the Orion is scheduled to launch atop a United Launch Alliance Delta IV Heavy rocket from Cape Canaveral Air Force Station in Florida in December to an altitude of 3,600 miles above the Earth's surface. The two-orbit, four-hour flight test will help engineers evaluate the systems critical to crew safety including the heat shield, parachute system and launch abort system. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Daniel Casper

KSC-2014-3782

NASA Image and Video Library

2014-09-10

CAPE CANAVERAL, Fla. – Inside the Neil Armstrong Operations and Checkout Building high bay at NASA's Kennedy Space Center in Florida, members of the Brevard Police and Fire Pipes and Drums lead NASA and Lockheed Martin workers toward the Orion crew module, stacked atop its service module. A ceremony will begin to officially turn over the Orion spacecraft for Exploration Flight Test-1 to Lockheed Martin Ground Operations from Orion Assembly, Integration and Production. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted test flight of the Orion is scheduled to launch atop a United Launch Alliance Delta IV Heavy rocket from Cape Canaveral Air Force Station in Florida in December to an altitude of 3,600 miles above the Earth's surface. The two-orbit, four-hour flight test will help engineers evaluate the systems critical to crew safety including the heat shield, parachute system and launch abort system. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Daniel Casper

KSC-2014-3791

NASA Image and Video Library

2014-09-10

CAPE CANAVERAL, Fla. – During a ceremony inside the Neil Armstrong Operations and Checkout Building high bay at NASA's Kennedy Space Center in Florida, the Orion spacecraft for Exploration Flight Test-1 was officially turned over to Lockheed Martin Ground Operations from Orion Assembly, Integration and Production. Holding the key during the turn over, are Jules Schneider, at left, Lockheed Martin Orion Production Operations manager, and Blake Hale, Lockheed Martin Ground Operations manager. Behind them are members of the Brevard Police and Fire Pipes and Drums. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted test flight of the Orion is scheduled to launch atop a United Launch Alliance Delta IV Heavy rocket from Cape Canaveral Air Force Station in Florida in December to an altitude of 3,600 miles above the Earth's surface. The two-orbit, four-hour flight test will help engineers evaluate the systems critical to crew safety including the heat shield, parachute system and launch abort system. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Daniel Casper

KSC-2014-3790

NASA Image and Video Library

2014-09-10

CAPE CANAVERAL, Fla. – During a ceremony inside the Neil Armstrong Operations and Checkout Building high bay at NASA's Kennedy Space Center in Florida, the Orion spacecraft for Exploration Flight Test-1 was officially turned over to Lockheed Martin Ground Operations from Orion Assembly, Integration and Production. Shaking hands during the turn over, are Jules Schneider, at left, Lockheed Martin Orion Production Operations manager, and Blake Hale, Lockheed Martin Ground Operations manager. Behind them are members of the Brevard Police and Fire Pipes and Drums. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted test flight of the Orion is scheduled to launch atop a United Launch Alliance Delta IV Heavy rocket from Cape Canaveral Air Force Station in Florida in December to an altitude of 3,600 miles above the Earth's surface. The two-orbit, four-hour flight test will help engineers evaluate the systems critical to crew safety including the heat shield, parachute system and launch abort system. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Daniel Casper

KSC-2014-3813

NASA Image and Video Library

2014-09-11

CAPE CANAVERAL, Fla. – Preparations are underway at the Neil Armstrong Operations and Checkout Building at NASA's Kennedy Space Center in Florida for the move of the Orion spacecraft for Exploration Flight Test-1 out of the high bay doors. Inside the high bay from left, are Jules Schneider, Lockheed Martin senior manager, and Kennedy Center Director Bob Cabana. The spacecraft will be transported to the Payload Hazardous Servicing Facility where it will be fueled ahead of its December flight test. Orion is the exploration spacecraft designed to carry astronauts to destinations not yet explored by humans, including an asteroid and Mars. It will have emergency abort capability, sustain the crew during space travel and provide safe re-entry from deep space return velocities. The first unpiloted test flight of the Orion is scheduled to launch atop a United Launch Alliance Delta IV Heavy rocket from Cape Canaveral Air Force Station in Florida to an altitude of 3,600 miles above the Earth's surface. The two-orbit, four-hour flight test will help engineers evaluate the systems critical to crew safety including the heat shield, parachute system and launch abort system. For more information, visit http://www.nasa.gov/orion. Photo credit: NASA/Daniel Casper

KSC-06pd0467

NASA Image and Video Library

2006-03-10

KENNEDY SPACE CENTER, FLA. - During the 2006 FIRST Robotics Regional Competition held March 9-11 at the University of Central Florida in Orlando, Kennedy Space Center Director Jim Kennedy and his intern Neil Berger talk with students on the Cocoa Beach High School-Rockledge High School robotic team known as the "Pink Team," which was co-sponsored by NASA KSC. The team's robot, at right, is called Roccobot. At least four teams in the competition were sponsored by KSC, NASA and contractors. The FIRST Robotics Competition challenges teams of young people and their mentors to solve a common problem in a six-week timeframe using a standard "kit of parts" and a common set of rules. Teams build robots from the parts and enter them in a series of competitions. FIRST, which is based on "For Inspiration and Recognition of Science and Technology," redefines winning for these students. Teams are rewarded for excellence in design, demonstrated team spirit, gracious professionalism and maturity, and ability to overcome obstacles. Scoring the most points is a secondary goal. Winning means building partnerships that last. NASA and the University of Central Florida are co-sponsors of the regional event, which this year included more than 50 teams. Photo credit: NASA/Kim Shiflett

NASA Administrator Dan Goldin greets Neil Armstrong at Apollo 11 anniversary banquet.

NASA Technical Reports Server (NTRS)

1999-01-01

During an anniversary banquet honoring the Apollo team, the people who made the entire lunar landing program possible, former Apollo astronaut Neil A. Armstrong (left) shakes the hand of Judy Goldin (center), wife of NASA Administrator Daniel S. Goldin (right). The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Among the guests at the banquet were former Apollo astronauts are Neil A. Armstrong and Edwin 'Buzz' Aldrin who flew on Apollo 11, the launch of the first moon landing; Gene Cernan, who flew on Apollo 10 and 17 and was the last man to walk on the moon; and Walt Cunningham, who flew on Apollo 7.

61. (Credit CBF) Operating floor of filter room, c1912. A ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

61. (Credit CBF) Operating floor of filter room, c1912. A remodeled Hyatt pressure filter, now operating as a tub, gravity, rapid sand filter, is in the foreground (the remodeling took place c1908-1909). The remodeled New York horizontal pressure filters (installed 01900, remodeled c1908-1909) are in the background. - McNeil Street Pumping Station, McNeil Street & Cross Bayou, Shreveport, Caddo Parish, LA

Agile-Lean Software Engineering (ALSE) Evaluating Kanban in Systems Engineering

DTIC Science & Technology

2013-03-06

Boeing)  Garry Roedler (Lockheed Martin)  Karl Scotland (Rally Software, UK)  Alan Shalloway (NetObjectives)  Neil Shirk (Lockheed Martin... Neil Siegel (Northrop Grumman)  James Sutton (Jubata Group) Thanks are also due to the members of the SERC Research Council, particularly Barry...Incremental Commitment Model to Brownfield Systems Development, Proceedings, CSER 2009, April 2009. 16. Heath , B. et al. (2009). A survey of agent-based

Agile and Lean Systems Engineering: Kanban in Systems Engineering

DTIC Science & Technology

2011-12-31

Rico (Boeing)  Garry Roedler (Lockheed Martin)  Karl Scotland (Rally Software, UK)  Alan Shalloway (NetObjectives)  Neil Shirk (Lockheed Martin... Neil Siegel (Northrop Grumman)  James Sutton (Jubata Group) Thanks are also due to the members of the SERC Research Council, particularly Barry...Commitment Model to Brownfield Systems Development, Proceedings, CSER 2009, April 2009. 14. Heath , B. et al. (2009). A survey of agent-based modeling

The Pendulum of War and Politics

DTIC Science & Technology

2013-05-16

Neil Sheehan, Fox Butterfield, Hendrick Smith and E. W. Kenworthy, The Pentagon Papers: The Secret History of the Vietnam War (New York: Quadrangle...65. Lexington: D.C. Heath and Company, 1995. McNamara, Robert S. In Retrospect, The Tragedy and Lessons of Vietnam. New York: Time Books, 1995...University Press of Kansas, 2005. Sheehan, Neil . The Pentagon Papers: As Published by the New York Times . Toronto, New York: Bantam Books , 1971. Sheehan

Ada in Introductory Computer Science Courses

DTIC Science & Technology

1993-01-01

Ada by Daniel F. Stubbs and Neil W. Webre Course Objective: To introduce the students to the basic classical data structures of computer science...Introduction to Ada, Chapman & Hall, 1993, London Dale/Weems/McCormick, Programming and Problem Solving with Ada, D. C. Heath and Company, 1994, MA Feldman...Daniel F. Stubbs and Neil W. Webre - Course Objective: To introduce the students to the basic classical data structures of computer science

Neil Armstrong Family Memorial Service

NASA Image and Video Library

2012-08-31

Apollo 13 Astronaut Jim Lovell, left, former NASA Administrator Dan Goldin, Sen. John Glenn, third from left, and NASA Administrator Charles Bolden, right, talk at a private memorial service celebrating the life of Neil Armstrong, Aug. 31, 2012, at the Camargo Club in Cincinnati. Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Bill Ingalls)

96. (Credit BLV) View locking West at Cross Lake dam ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

96. (Credit BLV) View locking West at Cross Lake dam and spillway constructed immediately west of Kansas City Southern railroad bridge. Booster station located at left. Note cribbing at bridge abutment in upper left which straddles gravity flow canduit installed in 1924-1926 and supports extra suction line (installed in 1930) on top. - McNeil Street Pumping Station, McNeil Street & Cross Bayou, Shreveport, Caddo Parish, LA

The Effects of Increasing Information Processing Demands on Rating Outcomes.

DTIC Science & Technology

1986-10-01

Resources Research THE EFFECTS OF INCREASING INFORMATION PROCESSING DEMANDS ON RATING OUTCOMES Roseanne J. Foti € and Neil M.A. Hauenstein October...j** ~-- .. ~ 87 7 0O2 p. THE EFFECTS OF INCREASING INFORMATION PROCESSING DEMANDS ON RATING OUTCOMES Roseanne J. Foti and -Neil M.A. Hauenstein...5- % Performance Ratings 2 Effects of Increasing Information Processing Demands on Rating Outcomes Abstract This research investigated the cognitive

Mentoring and Supervision in Healthcare Gopee Neil Mentoring and Supervision in Healthcare Sage Publications £22.99 304pp 9780857024190 0857024191 [Formula: see text].

PubMed

2011-10-26

THIS VOLUME is an excellent resource for experienced and new mentors and preceptors, with Neil Gopee setting out the knowledge base, skills and attitudes for successful mentoring. This second edition encompasses developments in health care and the recent standards and competencies that have been introduced for mentors and supervisors, with advice on how to implement them in clinical practice.

Neil Armstrong Family Memorial Service

NASA Image and Video Library

2012-08-31

U.S. Navy F/A-18 jets from Strike Fighter Squadron (VFA) 106 and Strike Fighter Squadron (VFA) 34, from Naval Air Station Oceana (Va.) fly in a "Missing Man" formation over the Camargo Club following a memorial service celebrating the life of Neil Armstrong, Friday, Aug. 31, 2012, in Cincinnati. Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Bill Ingalls)

Wessex Helicopter/Sonar Dynamics Study. ARL Program Description and Operation.

DTIC Science & Technology

1979-02-01

s): 5. Document Date: S illiams, Neil V. February, 1979 Guy, Christopher R. Williams, Maxwell J. 6. Type of Report and Period Covered: Gilbert, Neil...form with the aid of an analog computer type of block diagram, comprising a number of linked modules (called blocks), each one representing a particular...three types of statement, viz. configuration, parameter and function statements. The configuration statements describe the blocks used and specify the

The Right US Strategy for Iran

DTIC Science & Technology

2007-04-01

King , King of Kings , King of countries containing all kinds of men, King in this great earth far and wide, son of Hystaspes, an Achaemenian , a...Highlights of the Iraq Strategy Review, January 2007, http://www.whitehouse.gov/nsc/iraq/2007/iraq-strategy011007. pdf . 13 Greg Jaffe and Neil King Jr...do if Iraq Implodes?” August 2006, Brookings Report, (Washington DC) http://www.brook.edu/views/articles/pollack/20060820. pdf . 21 Neil King Jr. and

Sustaining Air Force Aging Aircraft into the 21st Century

DTIC Science & Technology

2011-08-01

Yankel, AFMC CXI SAB Members: Mrs. Natalie Crawford Prof Mark Goorsky Mr. Neil Kacena Prof. David W. Miller Dr. Robert Schafrik Prof. Douglas...D. Eick Professor Mark S. Goorsky Mr. Neil G. Kacena Professor David W. Miller Dr. Robert E. Schafrik Dr. Douglas C. Schmidt Professor Daniel L...AFB, UT. Ivey, R., & Heath , R. (2011, April). Implementing MECSIP Through a Reliability Centered Maintenance Program for the Air Force C-130 SPO

Defense Acquisition Research Journal. Volume 18, Number 4, Issue 60, October 2011

DTIC Science & Technology

2011-10-01

addition to the Defense Acquisition Profes- sional’s Reading List is Neil Sheehan’s comprehensive look at the cold war development of the...accomplishment has been completed (DoD, 2005a). 5. Defense Contract Management Agency 14 Point Schedule Assessment—A set of standardized schedule heath and...Ultimate Weapon author(s): Neil Sheehan Publisher: New York, Random House Copyright Date: 2009 iSBN: 0679422846 Hard/Softcover: Hardcover: 560

Set Based Program Analysis

DTIC Science & Technology

1992-10-01

Philosophy Thesis Committee: Peter Lee, Co-Chair Frank Pfenning, Co-chair Dana Scott Joxan Jaffar, IBM Neil Jones, DIKU, Copenhagen Copyright C 1992...much of this thesis represents joint work with him. I am also indebted to Peter Lee and Frank Pfenning, my advisors at CMU. Their encouragement...I am very grateful to Peter , Frank, Joxan and CMU that this has been a synergistic experience. I would like to thank Neil Jones and Dana Scott for

Effectiveness of Interagency Cooperation at the Provincial Reconstruction Team Level in Afghanistan

DTIC Science & Technology

2011-04-07

Carlisle, PA: Strategic Studies Institute, U.S. Army War College, 2009. Marcella , Gabriel, ed. Affairs of State: The Interagency and National Security...Joint Operations, vi. 12 O’Neil, 4. 13 Gabriel Marcella , ed., Affairs of State: The Interagency and National Security (Carlisle, PA: Strategic Studies...O’Neil, 4. 16 Marcella , 4-6. 17 Michele A. Flournoy, "Prepared Statement For House Armed Services Subcommittee on Oversight and Investigations

How DRB-XCL burners and air heater upgrade reduced NO sub x and improved efficiency at a western utility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Becker, W.; Stalcup, T.; Schild, V.

1992-01-01

The Neil Simpson Unit is a 220,000 lb/hr pulverized coal boiler that was designed to fire a local Wyoming subbituminous coal. During the late 1980s, the Wyoming Department of Air Quality imposed emission limits on the Black Hills Power and Light Co., Neil Simpson Station. The new limits required Black Hills power to control not only particulate and sulfur dioxide (SO{sub 2}) emissions, but also nitrogen oxide (NO{sub x}) emissions. At the same time, Black Hills Power initiated an efficiency improvement study at Neil Simpson Station to investigate methods for reducing net electrical generation costs. This paper addresses the plantmore » efficiency and emissions studies, startup activities, the operating problems and successful operating solutions for NO{sub x} control when firing a Wyoming subbituminous coal. Also included is a summary of the post-0retrofit boiler performance data.« less

34. (Credit JTL) Front (north side) of three water tube ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

34. (Credit JTL) Front (north side) of three water tube boilers built by the Heine Safety Boiler Co. of St. Louis, Missouri in 1917; rebuilt in 1938. Front doors opened on center boiler to show water header and inspection plugs for water tubes. Smaller doors beneath open into firebox; boilers presently equipped for gas firing. Operating pressure approx. 150 psi (saturated steam). - McNeil Street Pumping Station, McNeil Street & Cross Bayou, Shreveport, Caddo Parish, LA

Air and Space Museum Apollo 40th Celebration

NASA Image and Video Library

2009-07-19

Jazz pianist and singer Diana Krall holds a montage given to her by the STS-125 space shuttle crew along with Apollo 11 Astronaut Neil Armstrong at the Apollo 40th anniversary celebration held at the National Air and Space Museum, Monday, July 20, 2009 in Washington. From left, Michael J. Massimino, Michael T. Good, Gregory C. Johnson, Andrew J. Feustel, Krall, Scott D. Altman, Neil Armstrong, John M. Grunsfeld and Megan McArthur. Photo Credit: (NASA/Bill Ingalls)

Assessing the Impact of and Needs for Navy Language, Regional Expertise, and Culture Training

DTIC Science & Technology

2012-10-01

Assessing the Impact of and Needs for Navy Language, Regional Expertise, and Culture Training Neil B. Carey • Edward J. Schmitz • Zachary T...Francisco, CA, gives medication to a child during a medical & dental community assistance project (MEDCAP/DENCAP). Petty Officer Barker is stationed aboard...concerns about this questionnaire, please refer them to Neil Carey , Ph.D., at 703-824-2356 or careyn@cna.org. 77 78 Appendix D Appendix D

Fyn: A Key Regulator of Metastasis in Prostate Cancer

DTIC Science & Technology

2013-06-01

CSMC with Drs. Leland Chung, Michael Freeman, Neil Bhowmick, Beatrice Knudsen, Hyung Kim, Dolores DiVizio, Howard Sandler, and Stuart Holden... Heath EI, Posadas EM, Yu EY, Harrison MR, Bruce JY, Cho SY, Wilding GE, Fetterly GJ, Hangauer DG, Kwan MF, Dyster LM, Carducci MA. A phase 2 study of...assays of Fyn and Met Neil Bhowmick, PhD- cysteine as a biomarker in PCa (forthcoming clinical trial) Beatrice Knudsen, MD-PhD- MET/SRC/FYN

52. (Credit JTL) Interior view looking west at the two ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

52. (Credit JTL) Interior view looking west at the two crank-and-fly wheel high service engines. Steam cylinders of engines are to the left; water pumps and condensers to the right. The Worthington-Snow engine in the foreground was built with 18"x36" and 40"x36" cylinders; its pumps can deliver 5 mgd total from two 15" diameter plungers. - McNeil Street Pumping Station, McNeil Street & Cross Bayou, Shreveport, Caddo Parish, LA

New paradigms in the repair of oxidative damage in human genome: mechanisms ensuring repair of mutagenic base lesions during replication and involvement of accessory proteins.

PubMed

Dutta, Arijit; Yang, Chunying; Sengupta, Shiladitya; Mitra, Sankar; Hegde, Muralidhar L

2015-05-01

Oxidized bases in the mammalian genome, which are invariably mutagenic due to their mispairing property, are continuously induced by endogenous reactive oxygen species and more abundantly after oxidative stress. Unlike bulky base adducts induced by UV and other environmental mutagens in the genome that block replicative DNA polymerases, oxidatively damaged bases such as 5-hydroxyuracil, produced by oxidative deamination of cytosine in the template strand, do not block replicative polymerases and thus need to be repaired prior to replication to prevent mutation. Following up our earlier studies, which showed that the Nei endonuclease VIII like 1 (NEIL1) DNA glycosylase, one of the five base excision repair (BER)-initiating enzymes in mammalian cells, has enhanced expression during the S-phase and higher affinity for replication fork-mimicking single-stranded (ss) DNA substrates, we recently provided direct experimental evidence for NEIL1's role in replicating template strand repair. The key requirement for this event, which we named as the 'cow-catcher' mechanism of pre-replicative BER, is NEIL1's non-productive binding (substrate binding without product formation) to the lesion base in ss DNA template to stall DNA synthesis, causing fork regression. Repair of the lesion in reannealed duplex is then carried out by NEIL1 in association with the DNA replication proteins. NEIL1 (and other BER-initiating enzymes) also interact with several accessory and non-canonical proteins including the heterogeneous nuclear ribonucleoprotein U and Y-box-binding protein 1 as well as high mobility group box 1 protein, whose precise roles in BER are still obscure. In this review, we have discussed the recent advances in our understanding of oxidative genome damage repair pathways with particular focus on the pre-replicative template strand repair and the role of scaffold factors like X-ray repairs cross-complementing protein 1 and poly (ADP-ribose) polymerase 1 and other accessory proteins guiding distinct BER sub-pathways.

Plan for the Assessment and Evaluation of Individual and Team Proficiencies Developed by the DARWARS Environments

DTIC Science & Technology

2004-12-31

Research, 58( 1 ), 47-77. Herl, H. E., O’Neil, H. F ., Jr., Chung, G., & Schacter, J. (1999) Reliability and validity of a computer-based knowledge mapping...simulation: A meta analysis. International Journal of Instructional Media, 26( 1 ), 71-85. Leemkuil, H., de Jong, T., de Hoog , R., & Christoph, N. (2003...FINAL REPORT ON PLAN FOR THE ASSESSMENT AND EVALUATION OF INDIVIDUAL AND TEAM PROFICIENCIES DEVELOPED BY THE DARWARS ENVIRONMENTS Harold F . O’Neil

Determine the Impact of Novel BRCA1 Translation Start Sites on Therapy Resistance in Ovarian Cancer

DTIC Science & Technology

2017-09-01

Award Number: W81XWH-15-1-0197 TITLE: PRINCIPAL INVESTIGATOR: Neil Johnson, Ph.D. CONTRACTING ORGANIZATION: Institute for Cancer Research...Therapy Resistance in Ovarian Cancer The views, opinions and/or findings contained in this report are those of the author(s) and should not be...Start Sites on Therapy 5b. GRANT NUMBER Resistance in Ovarian Cancer W81XWH-15-1-0197 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER Neil

43. (Credit JTL) View down into # 3 low service ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

43. (Credit JTL) View down into # 3 low service pump pit from elevator car. Worthington low service pump frame on left with pumps at bottom. Tunnel opening leads to #1 low service pump pit. Electric pump housing closest to tunnel opening installed in 1943; pump could deliver 6 mgd. Certrifugal pump near steps was installed in 1947 and is driven by a shaft from a motor at the top of the pit. - McNeil Street Pumping Station, McNeil Street & Cross Bayou, Shreveport, Caddo Parish, LA

A US Strategy for Iran (Walker Paper, Number 11)

DTIC Science & Technology

2008-04-01

fpc .state.gov/documents/organization/23591. pdf . Keddie, Nikkie R. Modern Iran. New Haven, CT: Yale University Press, 2006. King , Neil, Jr., and Greg...for Iran. Note . Neil King Jr. and Greg Jaffe, “If Iraq Worsens, Allies See ‘Nightmare’ Case,” Wall Street Journal, 9 January 2007. Chapter 2...Iran’s Perceptions and Patterns—Historic Roots I am Darius the Great King , King of Kings , King of coun- tries containing all kinds of men, King in this

Artists concept of Apollo 11 Astronaut Neil Armstrong on the moon

NASA Technical Reports Server (NTRS)

1969-01-01

A Grumman Aircraft Engineering Corporation artist's concept depicting mankind's first walk on another celestianl body. Here, Astronaut Neil Armstrong, Apollo 11 commander, is making his first step onto the surface of the moon. In the background is the Earth, some 240,000 miles away. Armstrong. They are continuing their postflight debriefings. The three astronauts will be released from quarantine on August 11, 1969. Donald K. Slayton (right), MSC Director of Flight Crew Operations; and Lloyd Reeder, training coordinator.

WAZP Observations during MILDEX October-November 1983.

DTIC Science & Technology

1984-03-01

SIGMAR T TAPE 16 NEIL BROWN SENSOR FILE 16 01T 10 20 C30 s- 60 ’.4 70 10 15 20 22 24 26 33.0 33.5 34..0 * V S S *** * 22o 26-OCT-83 22 *37 TEMP, SALINITY... SIGMAR T TAPE 17 NEIL BROWN SENSOR FILE 3 0 10 20 3 0 I- so- .1*r 60 70 a a wl10 15 20 22 24. 26 33.0 33.5 34..0 26-OCT-83 23󈧕 TEMIP, SFLINITY

Aging and cholinergic responses in bovine trachealis muscle.

PubMed Central

Wills, M.; Douglas, J. S.

1988-01-01

1. The relative potencies of muscarinic agonists on bovine tracheal smooth muscle were unchanged as a consequence of aging and were carbachol greater than oxotremorine greater than muscarine greater than pilocarpine greater than McNeil A-343. 2. During aging, the potencies of carbachol, oxotremorine, McNeil A-343 and pilocarpine, but not muscarine, were reduced. 3. Maximal induced tensions to all the agents studied were reduced as a consequence of age. 4. Irreversible antagonism with benzilylcholine mustard showed that agonist efficacy was significantly reduced during aging. 5. Estimated receptor occupancy at the EC50 was significantly greater in tracheal tissues from the mature versus immature cows for every agonist studied. 6. The dissociation constants for full agonists (carbachol, oxotremorine and methacholine) were decreased with maturation while the converse was observed with partial agonists (McNeil A-343, pilocarpine). 7. We conclude that there are significant changes in the properties and coupling of muscarinic receptors during aging. These changes may contribute to the reduced airway reactivity seen in vivo. PMID:3390660

KSC-2011-6815

NASA Image and Video Library

2011-09-08

CAPE CANAVERAL, Fla. – Astrophysicist Dr. Neil deGrasse Tyson with the American Museum of Natural History’s Hayden Planetarium in New York, speaks to a group of Tweetup participants at NASA Kennedy Space Center’s NASA Causeway launch viewing site in Florida during prelaunch activities for the agency’s Gravity Recovery and Interior Laboratory (GRAIL) mission. Participants toured the center and got a close-up view of Space Launch Complex 17B at Cape Canaveral Air Force Station. The tweeters will share their experiences with followers through the social networking site Twitter. GRAIL will fly twin spacecraft in tandem around the moon to precisely measure and map variations in the moon’s gravitational field. The mission will provide the most accurate global gravity field to date for any planet, including Earth. This detailed information will reveal differences in the density of the moon’s crust and mantle and will help answer fundamental questions about the moon’s internal structure, thermal evolution, and history of collisions with asteroids. The aim is to map the moon’s gravity field so completely that future lunar vehicles can safely navigate anywhere on the moon’s surface. Launch is scheduled for 8:37:06 a.m. EDT Sept. 8. For more information, visit http://www.nasa.gov/grail. Photo credit: NASA/Kim Shiflett

KSC-2011-6814

NASA Image and Video Library

2011-09-08

CAPE CANAVERAL, Fla. – Astrophysicist Dr. Neil deGrasse Tyson with the American Museum of Natural History’s Hayden Planetarium in New York, speaks to a group of Tweetup participants at NASA Kennedy Space Center’s NASA Causeway launch viewing site in Florida during prelaunch activities for the agency’s Gravity Recovery and Interior Laboratory (GRAIL) mission. Participants toured the center and got a close-up view of Space Launch Complex 17B at Cape Canaveral Air Force Station. The tweeters will share their experiences with followers through the social networking site Twitter.GRAIL will fly twin spacecraft in tandem around the moon to precisely measure and map variations in the moon’s gravitational field. The mission will provide the most accurate global gravity field to date for any planet, including Earth. This detailed information will reveal differences in the density of the moon’s crust and mantle and will help answer fundamental questions about the moon’s internal structure, thermal evolution, and history of collisions with asteroids. The aim is to map the moon’s gravity field so completely that future lunar vehicles can safely navigate anywhere on the moon’s surface. Launch is scheduled for 8:37:06 a.m. EDT Sept. 8. For more information, visit http://www.nasa.gov/grail. Photo credit: NASA/Kim Shiflett

KSC-2011-6800

NASA Image and Video Library

2011-09-07

CAPE CANAVERAL, Fla. – Astrophysicist Dr. Neil deGrasse Tyson with the American Museum of Natural History’s Hayden Planetarium in New York, speaks to a group of Tweetup participants at the Kennedy Space Center Visitor Complex in Florida during prelaunch activities for the agency’s Gravity Recovery and Interior Laboratory (GRAIL) mission. Participants toured NASA’s Kennedy Space Center and got a close-up view of Space Launch Complex 17B at Cape Canaveral Air Force Station. The tweeters will share their experiences with followers through the social networking site Twitter. GRAIL will fly twin spacecraft in tandem around the moon to precisely measure and map variations in the moon’s gravitational field. The mission will provide the most accurate global gravity field to date for any planet, including Earth. This detailed information will reveal differences in the density of the moon’s crust and mantle and will help answer fundamental questions about the moon’s internal structure, thermal evolution, and history of collisions with asteroids. The aim is to map the moon’s gravity field so completely that future lunar vehicles can safely navigate anywhere on the moon’s surface. Launch is scheduled for 8:37:06 a.m. EDT Sept. 8. For more information, visit http://www.nasa.gov/grail. Photo credit: NASA/Gianni Woods

Direct Broad-Range Detection of Alphaviruses in Mosquito Extracts

DTIC Science & Technology

2007-11-25

D.J., Robbins, D.W., Hannis , J.C., Harrell, P.M., Massire, C., Hall, T.A., Jiang, Y., Ranken, R., Drader, J.J., White, N., McNeil, J.A., Crooke, S.T...962. Hofstadler, S.A., Sampath, R., Blyn, L.B., Eshoo, M.W., Hall, T.A., Jiang, Y., Drader, J.J., Hannis , J.C., Sannes-Lowery, K.A., Cummins, L.L...H., Hannis , J., Harrell, P.M., Neuman, B., Buchmeier, M.J., Jiang, Y., Ranken, R., Drader, J., Samant, V., Griffey, R.H., McNeil, J.A., Crooke, S.T

49. (Credit JTL) View looking northeast at #1 high service ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

49. (Credit JTL) View looking northeast at #1 high service pumping engine built in 1900 by Henry R. Worthington Hydraulic Works. This engine is a direct-acting, horizontal, triple expansion condensing engine with 12"x24", 19"x24" and 30"x24" cylinders and a pumping capacity of 3 to 4 mgd. Engine was in service until mid 1970's and remained on stand-by until August 1980. Doors behind engine lead to filter rooms. - McNeil Street Pumping Station, McNeil Street & Cross Bayou, Shreveport, Caddo Parish, LA

46. (Credit LSU) High service pumping room, c1904. The # ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

46. (Credit LSU) High service pumping room, c1904. The # 1 Worthington horizontal, triple expansion, high service engine is in the background. The pump whose steam end is in the foreground is a Blake compound, duplex horizontal engine, installed c1904. The engine in the center of the illustration is one of the original 1887 Blake high service engines (compound, duplex). It was shortly after removed. (From: Shreveport Progressive League, Shreveport of To-Day, September 1904, p. 47) - McNeil Street Pumping Station, McNeil Street & Cross Bayou, Shreveport, Caddo Parish, LA

X-Ray Outburst from Young Star in McNeil's Nebula

NASA Astrophysics Data System (ADS)

2004-07-01

Observations with NASA's Chandra X-ray Observatory captured an X-ray outburst from a young star, revealing a probable scenario for the intermittent brightening of the recently discovered McNeil's Nebula. It appears the interaction between the young star's magnetic field and an orbiting disk of gas can cause dramatic, episodic increases in the light from the star and disk, illuminating the surrounding gas. "The story of McNeil's Nebula is a wonderful example of the importance of serendipity in science," said Joel Kastner of the Rochester Institute of Technology in Rochester, New York, lead author of a paper in the July 22 issue of Nature describing the X-ray results. "Visible-light images were made of this region several months before Jay McNeil made his discovery, so it could be determined approximately when and by how much the star flared up to produce McNeil's Nebula." The small nebula, which lies in the constellation Orion about 1300 light years from Earth, was discovered with a 3-inch telescope by McNeil, an amateur astronomer from Paducah, Kentucky, in January 2004. In November 2002, a team led by Ted Simon of the Institute for Astronomy in Hawaii had observed the star-rich region with Chandra in search of young, X-ray emitting stars, and had detected several objects. Optical and infrared astronomers had, as part of independent surveys, also observed the region about a year later, in 2003. After the announcement of McNeil's discovery, optical, infrared and X-ray astronomers rushed to observe the region again. They found that a young star buried in the nebula had flared up, and was illuminating the nebula. This star was coincident with one of the X-ray sources discovered earlier by Simon. Chandra observations obtained by Kastner's group just after the optical outburst showed that the source had brightened fifty-fold in X-rays when compared to Simon's earlier observation. The visible-light eruption provides evidence that the cause of the X-ray outburst is the sudden infall of matter onto the surface of the star from an orbiting disk of gas. In general, the coupling of the magnetic field of the star and the magnetic field of its circumstellar disk regulates the inflow of gas from the disk onto the star. This slow, steady inflow suddenly can become much more rapid if a large amount of gas accumulates in the disk, and the disk and the star are rotating at different rates. The differing rotation rates would twist and shear the magnetic field, storing up energy. This energy is eventually released in an energetic, X-ray producing outburst as the magnetic field violently rearranges back to a more stable state. During this period, a large amount of gas can fall onto the star, producing the observed optical and infrared outburst. A new buildup of gas in the disk could lead to a new outburst in the future. Such a scenario may explain why the brightness of McNeil's Nebula appears to vary with time. It is faintly present in surveys of this region of Orion in images taken in the 1960s, but absent from images taken in the 1950s and 1990s. NASA's Marshall Space Flight Center, Huntsville, Ala., manages the Chandra program for NASA's Office of Space Science, Washington. Northrop Grumman of Redondo Beach, Calif., formerly TRW, Inc., was the prime development contractor for the observatory. The Smithsonian Astrophysical Observatory controls science and flight operations from the Chandra X-ray Center in Cambridge, Mass. Additional information and images are available at: http://chandra.harvard.edu and http://chandra.nasa.gov

Formation and processing of DNA damage substrates for the hNEIL enzymes.

PubMed

Fleming, Aaron M; Burrows, Cynthia J

2017-06-01

Reactive oxygen species (ROS) are harnessed by the cell for signaling at the same time as being detrimental to cellular components such as DNA. The genome and transcriptome contain instructions that can alter cellular processes when oxidized. The guanine (G) heterocycle in the nucleotide pool, DNA, or RNA is the base most prone to oxidation. The oxidatively-derived products of G consistently observed in high yields from hydroxyl radical, carbonate radical, or singlet oxygen oxidations under conditions modeling the cellular reducing environment are discussed. The major G base oxidation products are 8-oxo-7,8-dihydroguanine (OG), 5-carboxamido-5-formamido-2-iminohydantoin (2Ih), spiroiminodihydantoin (Sp), and 5-guanidinohydantoin (Gh). The yields of these products show dependency on the oxidant and the reaction context that includes nucleoside, single-stranded DNA (ssDNA), double-stranded DNA (dsDNA), and G-quadruplex DNA (G4-DNA) structures. Upon formation of these products in cells, they are recognized by the DNA glycosylases in the base excision repair (BER) pathway. This review focuses on initiation of BER by the mammalian Nei-like1-3 (NEIL1-3) glycosylases for removal of 2Ih, Sp, and Gh. The unique ability of the human NEILs to initiate removal of the hydantoins in ssDNA, bulge-DNA, bubble-DNA, dsDNA, and G4-DNA is outlined. Additionally, when Gh exists in a G4 DNA found in a gene promoter, NEIL-mediated repair is modulated by the plasticity of the G4-DNA structure provided by additional G-runs flanking the sequence. On the basis of these observations and cellular studies from the literature, the interplay between DNA oxidation and BER to alter gene expression is discussed. Copyright © 2017 Elsevier Inc. All rights reserved.

Why So Many More Americans Die in Fires

NASA Astrophysics Data System (ADS)

Cranberg, Lawrence

2009-03-01

``Why So Many More Americans Die in Fires'' is the headline on Page 3 of The New York Times' full-page story on December 22, l991, by D. G. McNeil, Jr. This is a partial report based on personal experience with domestic fire making for thermal comfort since l975 (1) and a published claim (2) of unique safety benefits.The McNeil report attributes the problem to ``A Case of Bad Attitude'' and ``A Reliance on Technology.'' That implies a ``bad attitude'' on the part of technologists - a conclusion consistent with this technologist's thirty-five years of experience with fellow technologists, who has found ``buck-passing'' the favorite recourse of technologists in the highest places in government even though, as McNeil has written, ``Many children never wake up. Smoke or toxic gases overcome them as they sleep. When fire fighters lift them, their imprints remain.'' Regrettably, in this author's experience, the courts have also displayed a ``bad attitude'' where ``life and death issues'' have been pleaded. 1. L. Cranberg, Slot Flame Stablity with Hohlraum Radiation Pattern, BAPS, Series II, Vol. 20, No. 9, Sept., l978. 2. L. Cranberg, Fireplace Firesafety, Fire Journal, Letter, May/June,l987

The West family chiropractic dynasty: celebrating a century of accomplishment in Canada: Part II: Samson J. West, David I. West, Neil A. West, Megan L. West, R. Ian Buchanan and James L. West.

PubMed

Brown, Douglas M

2011-06-01

This historical paper documents the unbroken legacy of the West family of chiropractors which has flourished in Canada for over 100 years. Part I, unearthed the origins, development and careers of Archibald West, the founder of this dynasty, his son Samuel and grandson Stephen. Part II, delves into the life of Archie's brother Samson, and Samson's chiropractic progeny: grandsons David and Neil, and great granddaughter Megan. Then it goes back to look at Stephen West's nephew, R. Ian Buchanan and ends with a descendant of another branch of the family tree, James L. West.

Saturn Apollo Program

NASA Image and Video Library

1969-08-03

The Apollo 11 mission, the first manned lunar mission, launched from the Kennedy Space Center, Florida via the Marshall Space Flight Center (MSFC) developed Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. Aboard the space craft were astronauts Neil A. Armstrong, commander; Michael Collins, Command Module (CM) pilot; and Edwin E. Aldrin Jr., Lunar Module (LM) pilot. The CM, piloted by Michael Collins remained in a parking orbit around the Moon while the LM, named “Eagle’’, carrying astronauts Neil Armstrong and Edwin Aldrin, landed on the Moon. During 2½ hours of surface exploration, the crew collected 47 pounds of lunar surface material for analysis back on Earth. The recovery operation took place in the Pacific Ocean where Navy para-rescue men recovered the capsule housing the 3-man Apollo 11 crew. The crew was airlifted to safety aboard the U.S.S. Hornet, where they were quartered in a Mobile Quarantine Facility (MQF) which served as their home until they reached the NASA Manned Spacecraft Center (MSC) Lunar Receiving Laboratory in Houston, Texas. The three are seen here at the MSC, still inside the MQF, undergoing their first debriefing on Sunday, August 3, 1969. Behind the glass are (L-R): Edwin Aldrin, Michael Collins, and Neil Armstrong.

Neil A. Armstrong

NASA Technical Reports Server (NTRS)

1958-01-01

Neil A. Armstrong joined the National Advisory Committee for Aeronautics at the Lewis Flight Propulsion Laboratory, Cleveland, Ohio, in 1955. He transferred to the NACA High-Speed Flight Station at Edwards Air Force Base, California, in July 1955, as an aeronautical research scientist. He became a research pilot later that year. Neil was named as one of nine astronauts for NASA's Gemini and Apollo Projects, leaving the Center for the National Aeronautics and Space Administration's Manned Spacecraft Center, Houston, Texas, in September 1962. Upon graduation from High School in 1947, Armstrong received a scholarship from the U.S. Navy. He enrolled at Purdue University to begin the study of aeronautical engineering. In 1949, the Navy called him to active duty and he became a navy pilot. In 1950, he was sent to Korea where he flew 78 combat missions from the carrier USS Essex in a Grumman F9F-2 Panther. He received the Air Medal and two Gold Stars. In 1952, Armstrong returned to Purdue University and graduated with a bachelors degree in aeronautical engineering in 1955. He later earned a masters degree in aerospace engineering from the University of Southern California. At the High-Speed Flight Station (which later became the NASA Dryden Flight Research Center) Armstrong served as project pilot on the North American F-100A and -C aircraft, McDonnell F-101, and the Lockheed F-104A. He also flew the Bell X-1B (4 flights, first on August 15, 1957), Bell X-5 (one flight, the last in the program, on October 25, 1955) and the Paresev. On November 30, 1960, Armstrong made his first flight in the X-15. He made a total of seven flights in the rocket plane reaching an altitude of 207,500 feet in the X-15-3 and a Mach number of 5.74 (3,989 mph) in the X-15-1. He left the Flight Research Center with a total of 2450 flying hours in more than 50 aircraft types. He was a member of the USAF-NASA Dyna-Soar Pilot Consultant Group, and studied X-20 Dyna-Soar approaches and abort maneuvers through use of the F-102A and F5D jet aircraft. Armstrong later accumulated a total of 8 days and 14 hours in space, including 2 hours and 48 minutes walking on the Moon. In March 1966, he was commander of the Gemini 8 mission that performed the first successful docking of two vehicles in space. As spacecraft commander for the Apollo 11 lunar mission, on July 20, 1969, he became the first human to set foot on the Moon. In 1970 he was appointed Deputy Associate Administrator for Aeronautics at NASA Headquarters. He resigned in 1971. Neil wrote several technical reports and presented a number of research papers. In June 1962, the Octave Chanute Award was presented to Neil by the Institute of the Aerospace Sciences. Other awards received by Neil have included the NASA Distinguished Service Medal and the NASA Exceptional Service Medal.

Neil Popovich | NREL

Science.gov Websites

(SEPIO). His areas of expertise include low temperature geothermal power production systems; mineral recovery from geothermal brines; fuel cell systems analysis/manufacturing/engineering; instrumentation

Charles L. Brewer Award for distinguished teaching of psychology: Neil Lutsky.

PubMed

2011-01-01

The American Psychological Foundation (APF) Charles L. Brewer Award for Distinguished Teaching of Psychology recognizes an outstanding career contribution to the teaching of psychology. The 2011 recipient of the Distinguished Teaching Award is Neil Lutsky. Dorothy W. Cantor, president of the APF, will present the APF Distinguished Teaching Award at the 119th Annual Convention of the American Psychological Association on August 5, 2011, at 4:00 p.m. Members of the 2011 APF Board of Trustees are Dorothy W. Cantor, president; William Howell, vice president/secretary; Gerald Koocher, treasurer; Elisabeth R. Straus, executive vice president/executive director; Norman Anderson; David H. Barlow, Camilla Benbow; Sharon Stephens Brehm; Charles L. Brewer; Connie Chan; Anthony Jackson; Ronald F. Levant; Sandra Shullman; Archie L. Turner; and Kurt Geisinger, APA Board of Directors liaison.

Dr. Neil deGrasse Tyson Visits NASA Goddard

NASA Image and Video Library

2017-12-08

Dr. Neil deGrasse Tyson visited with Goddard's Space Flight Center Director Chris Scolese and the James Webb Space Telescope team at Goddard in Greenbelt, Md. on June 3, 2014. Tyson spoke to the team and was able to see the giant vacuum test chamber that now holds the heart of the telescope, the Integrated Science Instrument Module. ..Learn more about JWST: www.jwst.nasa.gov..Credit: NASA/Goddard/Rebecca Roth..NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

Dr. Neil deGrasse Tyson Visits NASA Goddard

NASA Image and Video Library

2014-06-03

Dr. Neil deGrasse Tyson visited with Goddard's Space Flight Center Director Chris Scolese and the James Webb Space Telescope team at Goddard in Greenbelt, Md. on June 3, 2014. Tyson spoke to the team and was able to see the giant vacuum test chamber that now holds the heart of the telescope, the Integrated Science Instrument Module. ..Learn more about JWST: www.jwst.nasa.gov..Credit: NASA/Goddard/Rebecca Roth..NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

BIRTHDAY - ASTRONAUT NEIL A. ARMSTRONG

NASA Image and Video Library

1969-08-06

S69-40958 (5 August 1969) --- Astronaut Neil A. Armstrong, commander of the historic Apollo 11 lunar landing mission, and the first man to set foot on the Moon, cuts his birthday cake as he celebrated his 39th birthday. The crew still confined to the Crew Reception Area (CRA) of the Manned Spacecraft Center's (MSC) Lunar Receiving Laboratory (LRL). Armstrong was born on August 5, 1930, in Wapakoneta, Ohio. The cake was described as "standard two-layer, plain vanilla" on which was placed 39 candles. Eighteen of the persons quarantined with Armstrong assembled and sang happy birthday; and a champagne toast was offered. CRA support personnel are in the background. Astronauts Armstrong; Michael Collins, command module pilot; and Edwin E. Aldrin Jr., lunar module pilot, will be released from quarantine on August 11, 1969.

NASA Advisory Council Meeting

NASA Image and Video Library

2005-11-29

Dr. Neil DeGrasse Tyson, NASA Advisory Council member listens during a meeting of the council at the Rayburn House Office Building, Tuesday, Nov. 29, 2005, in Washington. Photo Credit: (NASA/Bill Ingalls)

Publications - GMC 280 | Alaska Division of Geological & Geophysical

Science.gov Websites

Publications Search Statewide Maps New Releases Sales Interactive Maps Databases Sections Geologic please see our publication sales page for more information. Bibliographic Reference Piggott, Neil, and

Prader-Willi syndrome

MedlinePlus

... Committee on Genetics. Clinical report - health supervision for children with Prader-Willi syndrome. Pediatrics. 2011;127(1):195-204. PMID: 21187304 www.ncbi.nlm.nih.gov/pubmed/21187304 . Review Date 4/19/2016 Updated by: Neil K. ...

Publications - GMC 275 | Alaska Division of Geological & Geophysical

Science.gov Websites

DGGS GMC 275 Publication Details Title: Geochemical analyses from the following North Slope oil/gas Piggott, Neil, 1997, Geochemical analyses from the following North Slope oil/gas exploratory well

Prenatal diagnosis of two fetuses with deletions of 8p23.1, critical region for congenital diaphragmatic hernia and heart defects.

PubMed

Keitges, Elisabeth A; Pasion, Romela; Burnside, Rachel D; Mason, Carla; Gonzalez-Ruiz, Antonio; Dunn, Teresa; Masiello, Meredith; Gebbia, Joseph A; Fernandez, Carlos O; Risheg, Hiba

2013-07-01

Microdeletions of 8p23.1 are mediated by low copy repeats and can cause congenital diaphragmatic hernia (CDH) and cardiac defects. Within this region, point mutations of the GATA4 gene have been shown to cause cardiac defects. However, the cause of CDH in these deletions has been difficult to determine due to the paucity of mutations that result in CDH, the lack of smaller deletions to refine the region and the reduced penetrance of CDH in these large deletions. Mice deficient for one copy of the Gata4 gene have been described with CDH and heart defects suggesting mutations in Gata4 can cause the phenotype in mice. We report on the SNP microarray analysis on two fetuses with deletions of 8p23.1. The first had CDH and a ventricular septal defect (VSD) on ultrasonography and a family history of a maternal VSD. Microarray analysis detected a 127-kb deletion which included the GATA4 and NEIL2 genes which was inherited from the mother. The second fetus had an incomplete atrioventricular canal defect on ultrasonography. Microarray analysis showed a 315-kb deletion that included seven genes, GATA4, NEIL2, FDFT1, CTSB, DEFB136, DEFB135, and DEFB134. These results suggest that haploinsufficiency of the two genes in common within 8p23.1; GATA4 and NEIL2 can cause CDH and cardiac defects in humans. Copyright © 2013 Wiley Periodicals, Inc.

12. Photocopy of sketch (original in possession of WACC) George ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. Photocopy of sketch (original in possession of WACC) George Dunn, photographer, 1892 'ORIGINAL HOME OF MR. AND MRS. NEIL ERICKSON IN BONITA CANYON ABOUT 1892' - Faraway Ranch, Willcox, Cochise County, AZ

Atmospheric Measurements for Flight Test at NASAs Neil A. Armstrong Flight Research Center

NASA Technical Reports Server (NTRS)

Teets, Edward H.

2016-01-01

Information enclosed is to be shared with students of Atmospheric Sciences, Engineering and High School STEM programs. Information will show the relationship between atmospheric Sciences and aeronautical flight testing.

View of Mission Control during lunar surface Apollo 11 EVA

NASA Image and Video Library

1969-07-20

Overall view of the Mission Operations Control Room in the Mission Control Center, bldg 30, during the lunar surface extravehicular activity (EVA) of Apollo 11 Astronauts Neil A. Armstrong and Edwin E. Aldrin Jr.

14. Photocopy of negative (original in possession of WACC), photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. Photocopy of negative (original in possession of WACC), photographer unknown, c.1908 EMMA AND NEIL ERICKSON IN FRONT OF BOARD AND BATTEN SOUTH WALL OF MAIN HOUSE - Faraway Ranch, Willcox, Cochise County, AZ

Multiple Sclerosis: Hope Through Research | NIH MedlinePlus the Magazine

MedlinePlus

... turn Javascript on. Feature: Multiple Sclerosis Hope Through Research Past Issues / Spring 2012 Table of Contents Neil ... a champion for those with MS and for research to find the causes and cures for the ...

The relative importance of fluid and kinetic frequency shifts of an electron plasma wave

NASA Astrophysics Data System (ADS)

Winjum, B. J.; Fahlen, J.; Mori, W. B.

2007-10-01

The total nonlinear frequency shift of a plasma wave including both fluid and kinetic effects is estimated when the phase velocity of the wave is much less than the speed of light. Using a waterbag or fluid model, the nonlinear frequency shift due to harmonic generation is calculated for an arbitrary shift in the wavenumber. In the limit where the wavenumber does not shift, the result is in agreement with previously published work [R. L. Dewar and J. Lindl, Phys. Fluids 15, 820 (1972); T. P. Coffey, Phys. Fluids 14, 1402 (1971)]. This shift is compared to the kinetic shift of Morales and O'Neil [G. J. Morales and T. M. O'Neil, Phys. Rev. Lett. 28, 417 (1972)] for wave amplitudes and values of kλD of interest to Raman backscatter of a laser driver in inertial confinement fusion.

Saturn Apollo Program

NASA Image and Video Library

1969-07-24

The Apollo 11 mission, the first manned lunar mission, launched from the Kennedy Space Center, Florida via the Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. The Saturn V vehicle was developed by the Marshall Space Flight Center (MSFC) under the direction of Dr. Wernher von Braun. Aboard were Neil A. Armstrong, commander; Michael Collins, Command Module (CM) pilot; and Edwin E. Aldrin Jr., Lunar Module (LM) pilot. The CM, piloted by Michael Collins remained in a parking orbit around the Moon while the LM, named “Eagle’’, carrying astronauts Neil Armstrong and Edwin Aldrin, landed on the Moon. Armstrong was the first human to ever stand on the lunar surface, followed by Edwin (Buzz) Aldrin. During 2½ hours of surface exploration, the crew collected 47 pounds of lunar surface material for analysis back on Earth. The recovery operation took place in the Pacific Ocean where Navy para-rescue men recovered the capsule housing the 3-man Apollo 11 crew. The crew was airlifted by helicopter and taken to safety aboard the U.S.S. Hornet, where they were quartered in a Mobile Quarantine Facility (MQF). Shown here are the Apollo 11 crew members (L to R) Neil Armstrong, Michael Collins, and Edwin Aldrin inside the MQF as U.S. President Richard Milhous Nixon speaks to them via intercom. The president was aboard the recovery vessel awaiting return of the astronauts. With the success of Apollo 11, the national objective to land men on the Moon and return them safely to Earth had been accomplished.

Saturn Apollo Program

NASA Image and Video Library

1969-07-24

Donned in biological isolation garments, the Apollo 11 crew members, (L-R) Edwin Aldrin, Neil Armstrong (waving), and Michael Collins exit the recovery pick up helicopter to board the U.S.S. Hornet aircraft carrier after splashdown. The recovery operation took place in the Pacific Ocean where Navy para-rescue men recovered the capsule housing the 3-man Apollo 11 crew. The crew was airlifted to safety aboard the U.S.S. Hornet, where they were quartered in a Mobile Quarantine Facility (MQF). This portable facility served as their home until they reached the NASA Manned Spacecraft Center (MSC) Lunar Receiving Laboratory in Houston, Texas. The Apollo 11 mission, the first manned lunar mission, launched from the Kennedy Space Center (KSC), Florida via the Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. Aboard were Neil A. Armstrong, commander; Michael Collins, Command Module (CM) pilot; and Edwin E. Aldrin Jr., Lunar Module (LM) pilot. The CM, piloted by Michael Collins remained in a parking orbit around the Moon while the LM, named “Eagle’’, carrying astronauts Neil Armstrong and Edwin Aldrin, landed on the Moon. Armstrong was the first human to ever stand on the lunar surface, followed by Aldrin. During 2½ hours of surface exploration, the crew collected 47 pounds of lunar surface material for analysis back on Earth. With the success of Apollo 11, the national objective to land men on the Moon and return them safely to Earth had been accomplished. The Saturn V vehicle was developed by the Marshall Space Flight Center (MSFC) under the direction of Dr. Werher von Braun.

Quarantined Apollo 11 Astronauts Addressed by U.S. President Nixon

NASA Technical Reports Server (NTRS)

1969-01-01

The Apollo 11 mission, the first manned lunar mission, launched from the Kennedy Space Center, Florida via the Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. The Saturn V vehicle was developed by the Marshall Space Flight Center (MSFC) under the direction of Dr. Wernher von Braun. Aboard were Neil A. Armstrong, commander; Michael Collins, Command Module (CM) pilot; and Edwin E. Aldrin Jr., Lunar Module (LM) pilot. The CM, piloted by Michael Collins remained in a parking orbit around the Moon while the LM, named 'Eagle'', carrying astronauts Neil Armstrong and Edwin Aldrin, landed on the Moon. Armstrong was the first human to ever stand on the lunar surface, followed by Edwin (Buzz) Aldrin. During 2½ hours of surface exploration, the crew collected 47 pounds of lunar surface material for analysis back on Earth. The recovery operation took place in the Pacific Ocean where Navy para-rescue men recovered the capsule housing the 3-man Apollo 11 crew. The crew was airlifted by helicopter and taken to safety aboard the U.S.S. Hornet, where they were quartered in a Mobile Quarantine Facility (MQF). Shown here are the Apollo 11 crew members (L to R) Neil Armstrong, Michael Collins, and Edwin Aldrin inside the MQF as U.S. President Richard Milhous Nixon speaks to them via intercom. The president was aboard the recovery vessel awaiting return of the astronauts. With the success of Apollo 11, the national objective to land men on the Moon and return them safely to Earth had been accomplished.

4. Photocopy of photograph (original in possession of Western Archeological ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Photocopy of photograph (original in possession of Western Archeological and Conservation Center (WACC), Tucson, Arizona), photographer unknown, undated NEIL ERICKSON WORKING OUTSIDE OFFICE/GARAGE WHEN IT WAS NEW - Faraway Ranch, Office-Garage, Willcox, Cochise County, AZ

Air and Space Museum Apollo 40th Celebration

NASA Image and Video Library

2009-07-19

Director of the Hayden Planetarium Neil deGrasse Tyson speaks as host of the Apollo 40th anniversary celebration held at the National Air and Space Museum, Monday, July 20, 2009 in Washington. Photo Credit: (NASA/Bill Ingalls)

Air and Space Museum Apollo 40th Celebration

NASA Image and Video Library

2009-07-19

Director of the Hayden Planetarium Neil deGrasse Tyson speaks as host of the Apollo 40th anniversary celebration held at the National Air and Space Museum, Monday, July 20, 2009 in Washington. Photo Credit: (NASA/Carla Cioffi)

Saturn Apollo Program

NASA Image and Video Library

1969-07-01

The crowning achievement for the Saturn V rocket came when it launched Apollo 11 astronauts, Neil Armstrong, Edwin (Buzz) Aldrin, and Michael Collins, to the Moon in July 1969. In this photograph, astronaut Aldrin takes his first step onto the surface of the Moon.

ARC-2011-ACD11-0206-036

NASA Image and Video Library

2011-12-01

Neil DeGrasse Tyson, Astrophysicist with Hayden Planetarium, the American Museum of Natural History, visits the Ames Kepler Science Team during the 1000 days since Launch Review. at reception speaking with Dr. David Morrison, Ames Serior Scientist, NASA Astrobiology, on right.

In Search of the Modern Hero.

ERIC Educational Resources Information Center

Shugar, Carol E.

1988-01-01

Provides profiles of contemporary figures who can serve as appropriate role models (heroes and heroines) for today's young people. Profiled are Desmond Tutu, Neil Armstrong, Mother Teresa, Lech Walesa, Jesse Jackson, Jacques Cousteau, Sharon Christa McAuliffe, and Anatoly Shcharansky. (SKC)

78 FR 65701 - Notice of Availability of the Nevada and Northeastern California Greater Sage-Grouse Draft Land...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-01

.../White Pine, Clan Alpine, Cortez; Desatoya, Desert, East Valley, Fish Creek, Gollaher, Islands, Lincoln, Lone Willow, Massacre, Monitor, North Fork, O'Neil Basin, Pine Forest, Reese River, Ruby Valley, Santa...

75 FR 42745 - Production Incentives for Cellulosic Biofuels: Notice of Program Intent

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-22

... gives notice that the Office of Biomass Program, in the Office of Energy Efficiency and Renewable Energy...: Questions may be directed to: Mr. Neil Rossmeissl, Office of the Biomass Program, U.S. Department of Energy...

41. Photocopy of negative (original in possession of WACC), photographer ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

41. Photocopy of negative (original in possession of WACC), photographer unknown, 1935 NEIL ERICKSON IN FRONT OF 'GARFIELD' FIREPLACE/CHIMNEY (NOTE: REAR PORCH IS ENCLOSED) - Faraway Ranch, Erickson-Riggs Ranch House, State Highway 181, Willcox, Cochise County, AZ

Apollo 11 Moon Landing

NASA Technical Reports Server (NTRS)

1969-01-01

The crowning achievement for the Saturn V rocket came when it launched Apollo 11 astronauts, Neil Armstrong, Edwin (Buzz) Aldrin, and Michael Collins, to the Moon in July 1969. In this photograph, astronaut Aldrin takes his first step onto the surface of the Moon.

Genome, Epigenome and RNA sequences of Monozygotic Twins Discordant for Multiple Sclerosis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Miller, Neil

2010-06-02

Neil Miller, Deputy Director of Software Engineering at the National Center for Genome Resources, discusses a monozygotic twin study on June 2, 2010 at the "Sequencing, Finishing, Analysis in the Future" meeting in Santa Fe, NM.

Evaluation of adaptive signal control technology--volume 1 : before-conditions data collection and analysis.

DOT National Transportation Integrated Search

2017-04-01

Field evaluation of adaptive signal control technologies (ASCT) is very important in understanding the systems contribution to safety : and operational efficiency. Data were collected at six intersections along the Neil Street corridor in Champaig...

Genome, Epigenome and RNA sequences of Monozygotic Twins Discordant for Multiple Sclerosis

ScienceCinema

Miller, Neil

2018-01-22

Neil Miller, Deputy Director of Software Engineering at the National Center for Genome Resources, discusses a monozygotic twin study on June 2, 2010 at the "Sequencing, Finishing, Analysis in the Future" meeting in Santa Fe, NM.

Short philtrum

MedlinePlus

... Textbook of Pediatrics . 20th ed. Philadelphia, PA: Elsevier; 2016:chap 125. Jones KL, Jones MC, Del Campo M. Facial-limb defects as major feature. In: Jones KL, Jones MC, Del Campo M, eds. Smith's Recognizable Patterns of Human ... Updated by: Neil K. Kaneshiro, MD, MHA, Clinical ...

Books for Summer Reading.

ERIC Educational Resources Information Center

Phi Delta Kappan, 1999

1999-01-01

"Kappan" editors recommend Michael Ignatieff's biography of Isaiah Berlin and insightful novels by Barbara Kingsolver, Pat Conroy, Wally Lamb, Edwidge Danticat, and Doris Lessing. Neil Postman's "The End of Education" (1995) advocates exploiting diversity to define standards. Ernest House's "Schools for Sale" (1998)…

The nucleotide-dependent interaction of FlaH and FlaI is essential for assembly and function of the archaellum motor

DOE PAGES

Chaudhury, Paushali; Neiner, Tomasz; D'Imprima, Edoardo; ...

2015-10-28

The motor of the membrane-anchored archaeal motility structure, the archaellum, contains FlaX, FlaI and FlaH. FlaX forms a 30 nm ring structure that acts as a scaffold protein and was shown to interact with the bifunctional ATPase FlaI and FlaH. However, the structure and function of FlaH has been enigmatic. Here we present structural and functional analyses of isolated FlaH and archaellum motor subcomplexes. The FlaH crystal structure reveals a RecA/Rad51 family fold with an ATP bound on a conserved and exposed surface, which presumably forms an oligomerization interface. FlaH does not hydrolyze ATP in vitro, but ATP binding tomore » FlaH is essential for its interaction with FlaI and for archaellum assembly. FlaH interacts with the C-terminus of FlaX, which was earlier shown to be essential for FlaX ring formation and to mediate interaction with FlaI. Electron microscopy reveals that FlaH assembles as a second ring inside the FlaX ring in vitro. Collectively these data reveal central structural mechanisms for FlaH interactions in mediating archaellar assembly: FlaH binding within the FlaX ring and nucleotide-regulated FlaH binding to FlaI form the archaellar basal body core.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chaudhury, Paushali; Neiner, Tomasz; D'Imprima, Edoardo

The motor of the membrane-anchored archaeal motility structure, the archaellum, contains FlaX, FlaI and FlaH. FlaX forms a 30 nm ring structure that acts as a scaffold protein and was shown to interact with the bifunctional ATPase FlaI and FlaH. However, the structure and function of FlaH has been enigmatic. Here we present structural and functional analyses of isolated FlaH and archaellum motor subcomplexes. The FlaH crystal structure reveals a RecA/Rad51 family fold with an ATP bound on a conserved and exposed surface, which presumably forms an oligomerization interface. FlaH does not hydrolyze ATP in vitro, but ATP binding tomore » FlaH is essential for its interaction with FlaI and for archaellum assembly. FlaH interacts with the C-terminus of FlaX, which was earlier shown to be essential for FlaX ring formation and to mediate interaction with FlaI. Electron microscopy reveals that FlaH assembles as a second ring inside the FlaX ring in vitro. Collectively these data reveal central structural mechanisms for FlaH interactions in mediating archaellar assembly: FlaH binding within the FlaX ring and nucleotide-regulated FlaH binding to FlaI form the archaellar basal body core.« less

2008 Leaders to Watch

ERIC Educational Resources Information Center

Technology Teacher, 2008

2008-01-01

This article features individuals who were selected by International Technology Education Association (ITEA) for their outstanding leadership ability as technology educators. These individuals include William F. Bertrand, Gerald F. Day, Neil Hancey, L. Bernard Hixson, Thomas Loveland, Kris Martini, and Jerianne Taylor. This article also details…

Air and Space Museum Apollo 40th Celebration

NASA Image and Video Library

2009-07-19

NASA Apollo 11 Mission Commander and first man to set foot on the Moon, Neil Armstrong speaks at the Apollo 40th anniversary celebration held at the National Air and Space Museum, Monday, July 20, 2009 in Washington. Photo Credit: (NASA/Bill Ingalls)

Air and Space Museum Apollo 40th Celebration

NASA Image and Video Library

2009-07-19

NASA Apollo 11 Mission Commander and first man to set foot on the Moon, Neil Armstrong speaks at the Apollo 40th anniversary celebration held at the National Air and Space Museum, Monday, July 20, 2009 in Washington. Photo Credit: (NASA/Carla Cioffi)

Minimization of Dependency Length in Written English

ERIC Educational Resources Information Center

Temperley, David

2007-01-01

Gibson's Dependency Locality Theory (DLT) [Gibson, E. 1998. "Linguistic complexity: locality of syntactic dependencies." "Cognition," 68, 1-76; Gibson, E. 2000. "The dependency locality theory: A distance-based theory of linguistic complexity." In A. Marantz, Y. Miyashita, & W. O'Neil (Eds.), "Image,…

Standards and Dialects in English.

ERIC Educational Resources Information Center

Shopen, Timothy; Williams, Joseph M.

A collection of essays on linguistic variation in English that distinguishes communities and social groups from one another includes: "Standard English: Biography of a Symbol" (Shirley Brice Heath); "The Rise of Standard English" (Margaret Shaklee); "English Orthography" (Wayne O'Neil); "How Pablo Says 'Love' and…

The NEIL Memory Research Unit: psychosocial, biological, physiological and lifestyle factors associated with healthy ageing: study protocol.

PubMed

Hannigan, Caoimhe; Coen, Robert F; Lawlor, Brian A; Robertson, Ian H; Brennan, Sabina

2015-01-01

Population ageing is a global phenomenon that has characterised demographic trends during the 20th and 21st century. The rapid growth in the proportion of older adults in the population, and resultant increase in the incidence of age-related cognitive decline, dementia and Alzheimer's disease, brings significant social, economic and healthcare challenges. Decline in cognitive abilities represents the most profound threat to active and healthy ageing. Current evidence suggests that a significant proportion of cases of age-related cognitive decline and dementia may be preventable through the modification of risk factors including education, depressive symptomology, physical activity, social engagement and participation in cognitively stimulating activities. The NEIL Memory Research Unit cohort study was established to investigate factors related to brain health and the maintenance of cognitive function. A cohort of 1000 normally ageing adults aged 50 years and over are being recruited to participate in comprehensive assessments at baseline, and at follow-up once every 2 years. The assessment protocol comprises a comprehensive neuropsychological battery, some basic physical measures, psychosocial scales, questionnaire measures related to a range of health, lifestyle and behavioural factors, and a measure of resting state activity using electroencephalography (EEG). The NEIL Memory Research Unit cohort study will address key questions about brain health and cognitive ageing in the population aged 50+, with a particular emphasis on the influence of potentially modifiable factors on cognitive outcomes. Analyses will be conducted with a focus on factors involved in the maintenance of cognitive function among older adults, and therefore will have the potential to contribute significant knowledge related to key questions within the field of cognitive ageing, and to inform the development of public health interventions aimed at preventing cognitive decline and promoting active and healthy ageing.

Comprehensive profiling of DNA repair defects in breast cancer identifies a novel class of endocrine therapy resistance drivers.

PubMed

Anurag, Meenakshi; Punturi, Nindo; Hoog, Jeremy; Bainbridge, Matthew N; Ellis, Matthew J; Haricharan, Svasti

2018-05-23

This study was undertaken to conduct a comprehensive investigation of the role of DNA damage repair (DDR) defects in poor outcome ER+ disease. Expression and mutational status of DDR genes in ER+ breast tumors were correlated with proliferative response in neoadjuvant aromatase inhibitor therapy trials (discovery data set), with outcomes in METABRIC, TCGA and Loi data sets (validation data sets), and in patient derived xenografts. A causal relationship between candidate DDR genes and endocrine treatment response, and the underlying mechanism, was then tested in ER+ breast cancer cell lines. Correlations between loss of expression of three genes: CETN2 (p<0.001) and ERCC1 (p=0.01) from the nucleotide excision repair (NER) and NEIL2 (p=0.04) from the base excision repair (BER) pathways were associated with endocrine treatment resistance in discovery data sets, and subsequently validated in independent patient cohorts. Complementary mutation analysis supported associations between mutations in NER and BER pathways and reduced endocrine treatment response. A causal role for CETN2, NEIL2 and ERCC1 loss in intrinsic endocrine resistance was experimentally validated in ER+ breast cancer cell lines, and in ER+ patient-derived xenograft models. Loss of CETN2, NEIL2 or ERCC1 induced endocrine treatment response by dysregulating G1/S transition, and therefore, increased sensitivity to CDK4/6 inhibitors. A combined DDR signature score was developed that predicted poor outcome in multiple patient cohorts. This report identifies DDR defects as a new class of endocrine treatment resistance drivers and indicates new avenues for predicting efficacy of CDK4/6 inhibition in the adjuvant treatment setting. Copyright ©2018, American Association for Cancer Research.

Serving My Family.

ERIC Educational Resources Information Center

Reclaiming Children and Youth, 2001

2001-01-01

The recipient of the year 2000 Kellogg's Hannah Neil World of Children Award was Father William Wasson, founder of Neustros Pequenos Hermanos [NPH], a network of orphanages in Mexico and Latin America. Since its beginning in 1953 the entire fabric of NPH is woven around the ethic of service. (Author)

9. Photocopy of photograph (original print in possession of WACC), ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Photocopy of photograph (original print in possession of WACC), photographer unknown, c.1900's NEIL ERICKSON ON LEDGE OVERLOOKING BONITA CANYON WITH STAFFORD CABIN IN FOREGROUND AND ERICKSON HOUSE IN DISTANCE (BOARD AND BATTEN PERIOD) - Faraway Ranch, Willcox, Cochise County, AZ

Identifying Determinants of PARP Inhibitor Sensitivity in Ovarian Cancer

DTIC Science & Technology

2015-10-01

such as those lacking functional BRCA1 are highly sensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. Ovarian cancer patients that harbored...Principal Investigator (Last, first, middle): Johnson, Neil  Dr. Johnson’s mentor, Dr. Jeffrey Boyd, left Fox Chase for Florida International

Air and Space Museum Apollo 40th Celebration

NASA Image and Video Library

2009-07-19

Director of the Hayden Planetarium Neil deGrasse Tyson watches as a video is played recognizing journalist Walter Cronkite during the Apollo 40th anniversary celebration held at the National Air and Space Museum, Monday, July 20, 2009 in Washington. Photo Credit: (NASA/Bill Ingalls)

X-15 AIRCRAFT - EDWARDS AFB (EAFB), CA

NASA Image and Video Library

1963-11-01

S63-19148 (1963) --- Neil A. Armstrong, a civilian, was a member of the second group of astronauts selected by the National Aeronautics and Space Administration. Armstrong was one of the nine picked in September, 1962. He was an aeronautical research pilot before becoming an astronaut.

FIELD MEASUREMENT OF DISSOLVED OXYGEN: A COMPARISON OF METHODS: JOURNAL ARTICLE

EPA Science Inventory

NRMRL-ADA- 00160 Wilkin*, R.T., McNeil*, M.S., Adair*, C.J., and Wilson*, J.T. Field Measurement of Dissolved Oxygen: A Comparison of Methods. Ground Water Monitoring and Remediation (Fall):124-132 (2001). EPA/600/J-01/403. The abili...

Reason and Culture in Cosmopolitan Education

ERIC Educational Resources Information Center

Waks, Leonard J.

2009-01-01

In this essay, Leonard Waks reviews three recent books on cosmopolitan education: Kwame Anthony Appiah's "Cosmopolitanism: Ethics in a World of Strangers"; Neil Burtonwood's "Cultural Diversity, Liberal Pluralism, and Schools: Isaiah Berlin and Education"; and Thomas Popkewitz's "Cosmopolitanism and the Age of School Reform: Science, Education and…

Evaluation of Adaptive Signal Control Technology—Volume 2 : Comparison of Base Condition to the First Year After Implementation

DOT National Transportation Integrated Search

2018-05-01

Field evaluation of adaptive signal control technologies (ASCT) is very important in understanding the systems contribution to safety and operational efficiency. Data were collected at six intersections along the Neil Street corridor in Champaign,...

Self-consistent Langmuir waves in resonantly driven thermal plasmas

NASA Astrophysics Data System (ADS)

Lindberg, R. R.; Charman, A. E.; Wurtele, J. S.

2007-12-01

The longitudinal dynamics of a resonantly driven Langmuir wave are analyzed in the limit that the growth of the electrostatic wave is slow compared to the bounce frequency. Using simple physical arguments, the nonlinear distribution function is shown to be nearly invariant in the canonical particle action, provided both a spatially uniform term and higher-order spatial harmonics are included along with the fundamental in the longitudinal electric field. Requirements of self-consistency with the electrostatic potential yield the basic properties of the nonlinear distribution function, including a frequency shift that agrees closely with driven, electrostatic particle simulations over a range of temperatures. This extends earlier work on nonlinear Langmuir waves by Morales and O'Neil [G. J. Morales and T. M. O'Neil, Phys. Rev. Lett. 28, 417 (1972)] and Dewar [R. L. Dewar, Phys. Plasmas 15, 712 (1972)], and could form the basis of a reduced kinetic treatment of plasma dynamics for accelerator applications or Raman backscatter.

DNA glycosylases search for and remove oxidized DNA bases.

PubMed

Wallace, Susan S

2013-12-01

This review article presents, an overview of the DNA glycosylases that recognize oxidized DNA bases using the Fpg/Nei family of DNA glycosylases as models for how structure can inform function. For example, even though human NEIL1 and the plant and fungal orthologs lack the zinc finger shown to be required for binding, DNA crystal structures revealed a "zincless finger" with the same properties. Moreover, the "lesion recognition loop" is not involved in lesion recognition, rather, it stabilizes 8-oxoG in the active site pocket. Unlike the other Fpg/Nei family members, Neil3 lacks two of the three void-filling residues that stabilize the DNA duplex and interact with the opposite strand to the damage which may account for its preference for lesions in single-stranded DNA. Also single-molecule approaches show that DNA glycosylases search for their substrates in a sea of undamaged DNA by using a wedge residue that is inserted into the DNA helix to probe for the presence of damage. Copyright © 2013 Wiley Periodicals, Inc.

Saturn Apollo Program

NASA Image and Video Library

1969-06-24

The Apollo 11 mission, the first manned lunar mission, launched from the Kennedy Space Center, Florida via the Marshall Space Flight Center (MSFC) developed Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. Aboard he space craft were astronauts Neil A. Armstrong, commander; Michael Collins, Command Module (CM) pilot; and Edwin E. Aldrin Jr., Lunar Module (LM) pilot. The CM, piloted by Michael Collins remained in a parking orbit around the Moon while the LM, named “Eagle’’, carrying astronauts Neil Armstrong and Edwin Aldrin, landed on the Moon. During 2½ hours of surface exploration, the crew collected 47 pounds of lunar surface material for analysis back on Earth. Splashdown occurred in the Pacific Ocean on July 24, 1969. This overall view of the Mission Operations Control Room in the Mission Control Center at the NASA Manned Spacecraft Center (MSC) in Houston Texas shows the jubilation of the celebration of mission success. Mission controllers wave their American flags just after Apollo 11 had been recovered from the Pacific Ocean.

Saturn Apollo Program

NASA Image and Video Library

1969-07-09

In this photograph, laboratory technician Bart Ruark visually inspects a Japanese Qail confined within a class III cabinet in the Intervertebrae, Aves, and Fish Laboratory of the Lunar Receiving Laboratory, Building 37 of the Manned Spacecraft Center (MSC) in Houston, Texas. This laboratory was part of the overall physical, chemical, and biological test program of the Apollo 11 returned lunar samples. Aboard the Marshall Space Flight Center (MSFC) developed Saturn V launch vehicle, the Apollo 11 mission launched from The Kennedy Space Center, Florida on July 16, 1969 and safely returned to Earth on July 24, 1969. The 3-man crew aboard the flight consisted of astronauts Neil A. Armstrong, commander; Edwin Aldrin, Lunar Module (LM) pilot; and Michael Collins, Command Module (CM) pilot. The CM, piloted by Michael Collins remained in a parking orbit around the Moon while the LM, named “Eagle’’, carrying astronauts Neil Armstrong and Edwin Aldrin, landed on the Moon. In 2 1/2 hours, the crew collected 47 pounds of lunar surface material which was returned to Earth for analysis.

Saturn Apollo Program

NASA Image and Video Library

1969-07-09

In this photograph, a laboratory technician handles a portion of the more than 20 different plant lines that were used within the Lunar Receiving Laboratory, Building 37 of the Manned Spacecraft Center (MSC) in Houston, Texas. This laboratory was part of the overall physical, chemical, and biological test program of the Apollo 11 returned lunar samples. Aboard the Marshall Space Flight Center (MSFC) developed Saturn V launch vehicle, the Apollo 11 mission launched from The Kennedy Space Center, Florida on July 16, 1969 and safely returned to Earth on July 24, 1969. The 3-man crew aboard the flight consisted of astronauts Neil A. Armstrong, commander; Edwin Aldrin, Lunar Module (LM) pilot; and Michael Collins, Command Module (CM) pilot. The CM, piloted by Michael Collins remained in a parking orbit around the Moon while the LM, named “Eagle’’, carrying astronauts Neil Armstrong and Edwin Aldrin, landed on the Moon. In 2 1/2 hours, the crew collected 47 pounds of lunar surface material which was returned to Earth for analysis.

Project Neil Bone: a great success!

NASA Astrophysics Data System (ADS)

Miles, R.

2010-08-01

Last October, the ARPS initiated a new observing project to make photometric observations of asteroids which reach a phase angle of 0.2° or less at opposition. The stimulus for this followed the naming last year of asteroid (7102) in honour of Neil Bone, our former Meteor Section Director, who sadly died last year. It turned out that (7102) would reach opposition on January 18 this year at an unusually low phase angle - just 0.03°. This is so small an angle that if you were standing on the asteroid on this date, you would be able to see the Earth transiting across the face of the Sun! The probability that (7102) would attain such a low phase angle is about once in several hundred years. So our project was set up with a view to observing its namesake along with a selection of thirteen other asteroids, which also happened to pass through very low phase angle at their opposition during the period 2009 October-2010 March.

A critical re-assessment of DNA repair gene promoter methylation in non-small cell lung carcinoma

PubMed Central

Do, Hongdo; Wong, Nicholas C.; Murone, Carmel; John, Thomas; Solomon, Benjamin; Mitchell, Paul L.; Dobrovic, Alexander

2014-01-01

DNA repair genes that have been inactivated by promoter methylation offer potential therapeutic targets either by targeting the specific repair deficiency, or by synthetic lethal approaches. This study evaluated promoter methylation status for eight selected DNA repair genes (ATM, BRCA1, ERCC1, MGMT, MLH1, NEIL1, RAD23B and XPC) in 56 non-small cell lung cancer (NSCLC) tumours and 11 lung cell lines using the methylation-sensitive high resolution melting (MS-HRM) methodology. Frequent methylation in NEIL1 (42%) and infrequent methylation in ERCC1 (2%) and RAD23B (2%) are reported for the first time in NSCLC. MGMT methylation was detected in 13% of the NSCLCs. Contrary to previous studies, methylation was not detected in ATM, BRCA1, MLH1 and XPC. Data from The Cancer Genome Atlas (TCGA) was consistent with these findings. The study emphasises the importance of using appropriate methodology for accurate assessment of promoter methylation. PMID:24569633

FlaA proteins in Leptospira interrogans are essential for motility and virulence but are not required for formation of the flagellum sheath.

PubMed

Lambert, Ambroise; Picardeau, Mathieu; Haake, David A; Sermswan, Rasana W; Srikram, Amporn; Adler, Ben; Murray, Gerald A

2012-06-01

Spirochetes have periplasmic flagella composed of a core surrounded by a sheath. The pathogen Leptospira interrogans has four flaB (proposed core subunit) and two flaA (proposed sheath subunit) genes. The flaA genes are organized in a locus with flaA2 immediately upstream of flaA1. In this study, flaA1 and flaA2 mutants were constructed by transposon mutagenesis. Both mutants still produced periplasmic flagella. The flaA1 mutant did not produce FlaA1 but continued to produce FlaA2 and retained normal morphology and virulence in a hamster model of infection but had reduced motility. The flaA2 mutant did not produce either the FlaA1 or the FlaA2 protein. Cells of the flaA2 mutant lacked the distinctive hook-shaped ends associated with L. interrogans and lacked translational motility in liquid and semisolid media. These observations were confirmed with a second, independent flaA2 mutant. The flaA2 mutant failed to cause disease in animal models of acute infection. Despite lacking FlaA proteins, the flagella of the flaA2 mutant were of the same thickness as wild-type flagella, as measured by electron microscopy, and exhibited a normal flagellum sheath, indicating that FlaA proteins are not essential for the synthesis of the flagellum sheath, as observed for other spirochetes. This study shows that FlaA subunits contribute to leptospiral translational motility, cellular shape, and virulence.

Enhancing Thinking through Cooperative Learning.

ERIC Educational Resources Information Center

Davidson, Neil, Ed.; Worsham, Toni, Ed.

This collection of papers provides a theoretical foundation on current practice in cooperative thinking. The papers offer many practical methods that can be applied to a full range of classroom settings. After an introduction, "HOTSICLE: Higher Order Thinking Skills in Cooperative Learning Environments" (Neil Davidson and Toni Worsham),…

A Research Program in Computer Technology

DTIC Science & Technology

1975-09-01

Dale M. Chase Neil M. Goldman Jeannette Christen~sen Norton R. Green feld Kathie Cole grove John F. Heafner Nancy Dechter James Koda Oralio E. Garza...Thomas L. Boynton Stephen L. Casner E. Randolph Cole James Koda Robert Parker Paul Raveling Dono Van-Mierop Research Assistant: John K. Kastner

Journal of Business and Training Education, 1996.

ERIC Educational Resources Information Center

Journal of Business and Training Education, 1996

1996-01-01

This annual serial issue contains six papers dealing with business education and training. "A Direction for Focusing Business Curricula" (Sharon Lund O'Neil) discusses the standards against which business curricula of the future must be measured. The importance of business communication in general education programs is emphasized in…

50th Anniversary First American to Orbit Earth

NASA Image and Video Library

2012-02-20

Apollo 11 Astronaut Neil Armstrong speaks during a celebration dinner at Ohio State University honoring the 50th anniversary of John Glenn's historic flight aboard Friendship 7 Monday, Feb. 20, 2012, in Columbus, Ohio. Glenn was the first American to orbit Earth. Photo Credit: (NASA/Bill Ingalls)

Speaking of Reading.

ERIC Educational Resources Information Center

Rosenthal, Nadine

Written in the tradition of Studs Terkel, this book presents oral histories of 77 diverse readers (from avid to infrequent readers) about how reading affects their lives. Sprinkled throughout the book are narratives of nationally recognized personalities, such as Maxine Hong-Kingston, Robert MacNeil, Gloria Steinem, Linus Pauling, Julie Harris,…

77 FR 44310 - Quarterly Publication of Individuals, Who Have Chosen To Expatriate, as Required by Section 6039G

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-27

... JACINTA YEUNG CHEONG CHANG MICHAEL YIO-HOW CHENG NICOLAS VINCENT CHI TELLY TAI HSUAN CHINOY SAMIR MUSTAPHA... TONJA YVONNE SU JIN CHIN SU XIAOBO SARA SHAO SUEN SAMSON C. L. SY KEVIN NEIL TAN LAI HING THARALDSEN...

Aldrin, Edwin Eugene, Jr [`Buzz'] (1930-)

NASA Astrophysics Data System (ADS)

Murdin, P.

2000-11-01

Astronaut, born in Montclair, NJ, trained as a fighter pilot (Korean War), he space-walked during the Gemini 12 mission, and was pilot of the lunar module of Apollo 11, the first manned lunar landing. Aldrin followed NEIL ARMSTRONG as the second man to walk on the Moon....

Viewpoint: Back to the Basics in Social Studies? Personal Statements by Three Canadian Educators

ERIC Educational Resources Information Center

Sutherland, Neil; And Others

1977-01-01

Neil Sutherland discusses the historical context of the back to basics movement in social studies. Ken Osborne points out that the movement is stifling innovation. Max van Manen addresses the question of what curricula should be considered basic. (Author/RM)

President Obama Meets with Crew of Apollo 11

NASA Image and Video Library

2009-07-19

President Barack Obama poses with Apollo 11 astronauts, from left, Buzz Aldrin, Michael Collins, and Neil Armstrong, Monday, July 20, 2009, in the Oval Office of the White House in Washington, on the 40th anniversary of the Apollo 11 lunar landing. Photo Credit: (NASA/Bill Ingalls)

Variability Of Microcystin-LR Standards Available From Commercial Vendors

EPA Science Inventory

VARIABILITY OF MICROCYSTIN-LR STANDARDS AVAILABLE FROM COMMERCIAL VENDORS II: TOXICOLOGICAL EVALUATION Donna Hill1, Neil Chernoff1, Thao Le2, Johnsie R. Lang2, Judy Schmid1 1 NHEERL, U.S. Environmental Protection Agency, Research Triangle Park, NC 2 Oak Ridge Institute for Sci...

Prince Rabbiteye Blueberry

USDA-ARS?s Scientific Manuscript database

'Prince' is a new early ripening rabbiteye blueberry released by the U.S. Depaertment of Agriculture's Agricultural Research Service. Prince was selected from a cross of MS 598 and FL 80-11 in 1996, and tested in field plantings at McNeil and Stone County, MS beginning in 2000. Prince flowers and...

WATER EGRESS

NASA Image and Video Library

1965-07-16

S65-28459 (16 July 1965) --- Astronaut Neil A. Armstrong, command pilot for the Gemini-5 backup crew, inside the Gemini Static Article 5 spacecraft prior to water egress training in the Gulf of Mexico. The training is part of the prelaunch schedule for prime and backup crew on the Gemini-5 mission.

Senate Hearing

NASA Image and Video Library

2012-03-07

Astrophysicist, American Museum of Natural History and Director, Hayden Planetarium Dr. Neil deGrasse Tyson testifies during a U.S. Senate Committee on Commerce, Science, and Transportation hearing on Wednesday, March 7, 2012 in Washington. NASA Administrator Charles Bolden testified at the same hearing prior to Tyson. Photo Credit: (NASA/Bill Ingalls)

Diversity Challenged: Evidence on the Impact of Affirmative Action.

ERIC Educational Resources Information Center

Orfield, Gary, Ed.

This collection of papers explores research on how increasing minority enrollment changes and enriches the educational process. The papers are: (1) "Student Diversity and Higher Learning" (Neil L. Rudenstine); (2) "A Policy Framework for Reconceptualizing the Legal Debate Concerning Affirmative Action in Higher Education"…

Children and Chess: A Guide for Educators

ERIC Educational Resources Information Center

Root, Alexey

2006-01-01

"Children and Chess: A Guide for Educators" is the first book to show the connection between accepted educational theories and chess. The relationship of chess to academic and humanistic educational goals is convincingly illustrated as curriculum and psychological theories from John D. McNeil, Mihaly Csikszentmihalyi, and Howard Gardner are…

House Hearing NASA Human Spaceflight Plan

NASA Image and Video Library

2010-05-25

Apollo 11 Commander Neil Armstrong makes a point as he testifies during a hearing before the House Science and Technology Committee, Tuesday, May 26, 2010, at the Rayburn House office building on Capitol Hill in Washington. The hearing was to review proposed human spaceflight plan by NASA. Photo Credit: (NASA/Paul E. Alers)

Measuring Motivation, Morale and Job Satisfaction in Army Careers

DTIC Science & Technology

1975-05-30

outcomes for people in general to estimate their relative effectiveness as reinforcers or incentives. Datel & Legters (1971) and Bialek & McNeil (1968...This editing should be done so the outcomes are made fairly specific, perhaps not as specific as the outcomes used by Datel & Legters (1971) (e.g

Air and Space Museum Apollo 40th Celebration

NASA Image and Video Library

2009-07-19

Former Maryland Lieutenant Governor and niece of President John F. Kennedy, Kathleen Kennedy Townsend speaks As Neil Armstrong, Background, and others approach the stage at the Apollo 40th anniversary celebration held at the National Air and Space Museum, Monday, July 20, 2009 in Washington. Photo Credit: (NASA/Bill Ingalls)

The Need for Developmental Models in Supervising School Counselors

ERIC Educational Resources Information Center

Gallo, Laura L.

2013-01-01

Developmental models, like Stoltenberg, McNeil, and Delworth's integrated developmental model (IDM) for supervision (1998), provide supervisors with an important resource in understanding and managing the counseling student's development and experience. The current status of school counseling supervision is discussed as well as the…

Armstrong Memorial Service

NASA Image and Video Library

2012-09-13

Musician Diana Krall sings ""Fly Me to the Moon" during a memorial service celebrating the life of Neil Armstrong at the Washington National Cathedral, Thursday, Sept. 13, 2012. Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Paul E. Alers)

Institute for the Study of Human Capabilities: Summary Descriptions of Research for the Period December 1989 through September 1990

DTIC Science & Technology

1991-05-30

Gallaudet Univesity Hearing & Communication W. Neil Charman. Ph.D. University of Manchester Visual Sciences Institute of Science & Technology Paul M...Capabilities, Indiana University, Bloomington, IN. Formal properties of cognitive representations. Port, van Gelder Since September, 1990, Timothy van

Engineered Bio-Molecular Nano-Devices/Systems

DTIC Science & Technology

2009-03-01

molecules with proper size will be captured by BCD and produce current blockage events, including, e.g., ibuprofen and thalidomide [37]. However, since...detection of enantiomers ," J. Am. Chem. Soc, vol. 128, pp. 10684-10685, 2006. [38] F. Sachs, J. Neil, and N. Barkakati, "The Automated-Analysis of

Crew Quarters Modifications

NASA Image and Video Library

2018-03-30

Modifications and upgrades are underway inside the Astronaut Crew Quarters in the Neil Armstrong Operations and Checkout Building at NASA's Kennedy Space Center in Florida. The crew quarters are being prepared for the next generation of space explorers. The historic facility housed Apollo and space shuttle astronauts before and after their missions into space.

KSC-as11-44-6549

NASA Image and Video Library

1969-07-19

JOHNSON SPACE CENTER, HOUSTON, TEXAS - A view of the Earth appears over the lunar horizon as the Apollo 11 Command Module comes into view of the Moon before astronauts Neil Armstrong and Edwin Aldrin Jr. leave in the Lunar Module, Eagle, to become the first men to walk on the Moon's surface.

Technology, Media Monopolies and Curriculum.

ERIC Educational Resources Information Center

Beadle, Mary E.

Neil Postman describes the United States in the late 20th century as the only "technopoly" (a society that has totally surrendered to technology, information, and science) in the world, and he asks educators to resist technopoly by changing curriculum. In his book "Technopoly," Postman proposes that cultures may be classified…

Armstrong Memorial Service

NASA Image and Video Library

2012-09-13

Former Secretary of the Treasury John Snow speaks during a memorial service celebrating the life of Neil Armstrong at the Washington National Cathedral, Thursday, Sept. 13, 2012. Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Bill Ingalls)

Swift UVOT Observations of SN2018apl/ASASSN-18gq

NASA Astrophysics Data System (ADS)

Brown, Peter J.

2018-04-01

SN2018apl/ASASSN-18gq (ATEL #11500) was observed by the Neil Gehrels Swift Observatory beginning 2018-04-03 15:28:06. We measured the magnitudes below from summed images from the first orbit of observations using the Swift Optical Ultraviolet Supernova Archive (SOUSA; Brown et al. 2014).

Sounds Alive: A Noise Workbook.

ERIC Educational Resources Information Center

Dickman, Donna McCord

Sarah Screech, Danny Decibel, Sweetie Sound and Neil Noisy describe their experiences in the world of sound and noise to elementary students. Presented are their reports, games and charts which address sound measurement, the effects of noise on people, methods of noise control, and related areas. The workbook is intended to stimulate students'…

Badhwar-O'Neil 2007 Galactic Cosmic Ray (GCR) Model Using Advanced Composition Explorer (ACE) Measurements for Solar Cycle 23

NASA Technical Reports Server (NTRS)

ONeill, P. M.

2007-01-01

Advanced Composition Explorer (ACE) satellite measurements of the galactic cosmic ray flux and correlation with the Climax Neutron Monitor count over Solar Cycle 23 are used to update the Badhwar O'Neill Galactic Cosmic Ray (GCR) model.

President Nixon welcomes the Apollo 11 astronauts aboard the U.S.S. Hornet

NASA Technical Reports Server (NTRS)

1969-01-01

President Richard M. Nixon welcomes the Apollo 11 astronauts aboard the U.S.S. Hornet. Already confined to the Mobile Quarantine Facility are (left to right) Neil A. Armstrong, commander; Michael Collins, command module pilot; and Edwin E. Aldrin Jr., lunar module pilot.

Enhancements and Extensions of Formal Models for Risk Assessment in Software Projects

DTIC Science & Technology

2002-09-01

the five defect categories. Cosmetic Defects. The name that corresponds to QSM®’s cosmetic defects. Cosmetic defects can be described as deferred...California. June 2002. (Fent00) Fenton , N. E. and Neil, M., Software Metrics: Roadmap. Proceedings of the Conference on the Future of Software

Gorsuch, the Judicious Judge: A Common-Sense Approach to Education Issues

ERIC Educational Resources Information Center

Bolick, Clint

2017-01-01

This article discusses concerns about how Neil M. Gorsuch, a U.S. Supreme Court nominee, might influence decisions regarding cases involving the appropriate scope of services guaranteed by federal special-education law, government aid to religious institutions providing educational services, and how intellectual property law applies to sports…

Language and Power: English as a Patriarchal Language.

ERIC Educational Resources Information Center

Stanley, Julia Penelope

In an "Esquire" magazine column, John Simon attempts to trivialize, through visual satire, the articulation by Wayne O'Neil of the linguistic position that teaching standard English perpetuates oppression and is itself oppressive; but his attempt provides, instead, a vivid representation of the political relationship between the teaching of…

A National Look at Children and Families Entering Early Intervention

ERIC Educational Resources Information Center

Scarborough, Anita A.; Spiker, Donna; Mallik, Sangeeta; Hebbeler, Kathleen M.; Bailey Jr., Donald B.; Simeonsson, Rune J.

2004-01-01

The National Early Intervention Longitudinal Study (NEILS) is the first study of Part C of the Individuals With Disabilities Education Act (IDEA) early intervention system with a nationally representative sample of infants and toddlers with disabilities. This article presents national estimates of characteristics of infants and toddlers and their…

Apollo 11 Geology training

NASA Image and Video Library

1969-03-05

S69-25944 (25 Feb. 1969) --- These two Apollo 11 crew astronauts study rock samples during a geological field trip to the Quitman Mountains area near the Fort Quitman ruins in far west Texas. Neil A. Armstrong (in background) is the Apollo 11 commander; and Edwin E. Aldrin Jr. is the lunar module pilot.

Department of Transportation Semiannual Regulatory Agenda

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-26

... enable the public to be more aware of and allow it to more effectively participate in the Department's... INFORMATION CONTACT: General You should direct all comments and inquiries on the agenda in general to Neil R... inquiries on particular items in the agenda to the individual listed for the regulation or the general...

Discretion over Valor: The AAUP during the McCarthy Years

ERIC Educational Resources Information Center

Aby, Stephen H.

2009-01-01

In recent years, there has been considerable and renewed interest in the effects of McCarthyism on academia. Ellen Schrecker's "No Ivory Tower" (1986), Lionel Lewis' "Cold War on Campus" (1988), David Holmes' "Stalking the Academic Communist" (1989), Charles McCormick's "This Nest of Vipers" (1989), Neil Hamilton's "Zealotry and Academic Freedom"…

View - Mission Control Center (MCC) - Lunar Surface - Apollo XI Extravehicular Activity (EVA) - MSC

NASA Image and Video Library

1969-07-20

S69-39815 (20 July 1969) --- Interior view of the Mission Operations Control Room (MOCR) in the Mission Control Center (MCC) during the Apollo 11 lunar extravehicular activity (EVA). The television monitor shows astronauts Neil A. Armstrong and Edwin E. Aldrin Jr. on the surface of the moon.

76 FR 63960 - NGP Capital Resources Company, et al.;

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-14

...: Bruce R. MacNeil, Senior Counsel, at (202) 551-6817, or Janet M. Grossnickle, Assistant Director, at... has a five-member board of directors (``Board'') of which three members are not interested persons of the Company within the meaning of section 2(a)(19) of the Act (``Independent Directors''). \\1\\ Section...

Welcoming a New Generation to College: The Millennial Students

ERIC Educational Resources Information Center

Elam, Carol; Stratton, Terry; Gibson, Denise D.

2007-01-01

High on any required reading list for college-level student affairs officers and high school counselors is "Millennials Rising: The Next Great Generation" by Neil Howe and William Strauss (2000). Experts on generational change in the United States, the authors contend that the current generation of college-age and pre-college-age…

Orion Crew Module Structural Test Article Arrival

NASA Image and Video Library

2016-11-14

NASA’s Super Guppy aircraft touches down at the Shuttle Landing Facility at the agency’s Kennedy Space Center in Florida, carrying the Orion crew module structural test article (STA). The STA will be offloaded and transported to the Neil Armstrong Operations and Checkout Building high bay for further testing. Photo credit: NASA/Kim Shiflett

When Social Identities Collide: Commentary on "Gender in the Management Education Classroom"

ERIC Educational Resources Information Center

Patton, Eric

2010-01-01

This commentary to "Gender in the Management Education Classroom" (Bilimoria, O'Neil, Hopkins, & Murphy, 2010) employs social identity and self-categorization theory to analyze the incident described in the article. In any MBA classroom, students are dealing with multiple group memberships. Similar to workplace settings, when the focus is on…

2009 Joint Service Power Expo volume 2 video

DTIC Science & Technology

2009-05-07

8483 - “A Field-Portable Lithium Ion Battery Charger with UPS Back-up Capability”, Mr. Neil Steven Graves, Acumentrics · 8394 - “Kestrel...Control”, Mr. Rick Silva, Sr. System Engineer, Custom Manufacturing & Engineering, Inc · 8371 - “New Application of Lithium - Ion Battery in Hybrid Power Supply System”, Mr. Takefumi Inoue, GS Yuasa Corporation

Disaster Planning Guidelines for Fire Chiefs.

DTIC Science & Technology

1980-07-01

book Money Receipts e I pad white squared paper * I roll masking tape (8 X 13) (-" × 60yds) * 3 spring clips * 3 felt tip markers (red, e I pkg. freezer...Avenue COMMIT EE HaRm Washington. D.C. 20012 C.Holy Redeemer Rectory (202) 723-0800 C. Neil Molenaar 9705 Summit Avenue Director, Domestic Programs

78 FR 25128 - Self-Regulatory Organizations; Fixed Income Clearing Corporation; Notice of Filing of Amended...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-29

...: The Securities and Exchange Commission published a document in the Federal Register of April 17, 2013... contained an incorrect citation regarding the Director of the Division of Trading and Markets' delegated authority to publish notice of such an application. FOR FURTHER INFORMATION CONTACT: Neil Lombardo, Division...

The University and the Inner City: A Redefinition of Relationships.

ERIC Educational Resources Information Center

Spikes, W. Franklin, Ed.

The university and the inner city is examined in this collection of papers. Chapters include: Establishing an Urban Commuter University: The Need for Community (Reynold Feldman and Barbara Hursh); Adult and Community Education: Mobilizing the Resources of the City (Roger Hiemstra); The Arts and Humanities in an Urban Environment (Neil Rudin);…

Values Education at Greenfield Lower School: The Seamless Robe

ERIC Educational Resources Information Center

Alexander, Elise; Thomas, Diane

2004-01-01

In this article the author describes a whole-school values education programme at Greenfield Lower School, a small village school near the town of Flitwick, England. The programme, based on the work of Neil Hawkes, senior advisor with Oxfordshire LEA, is designed "to help the school community think about and reflect upon positive universal…

Enhanced X-ray Activity of the UHBL Source 1ES 0033+595

NASA Astrophysics Data System (ADS)

Kapanadze, Bidzina

2018-04-01

The TeV-detected ultra-high-energy peaked BL Lacertae source (UHBL) 1ES 0033+595 was observed 87 times with X-Ray Telescope (XRT) onboard the Neil Geherels Swift Observatory since 2005 April 1 with a total exposure of 117 ks (Mostly, in the framework of our ToO requests).

Orion Space Hardware In-Production inside the Operations and Che

NASA Image and Video Library

2017-10-03

Thermal protection system panels are in view in the high bay of the Neil Armstrong Operations and Checkout Building at NASA's Kennedy Space Center in Florida. The Orion crew module for NASA’s Exploration Mission 1 (EM-1) is being prepared for its first integrated flight atop the Space Launch System rocket.

Publications - GMC 279 | Alaska Division of Geological & Geophysical

Science.gov Websites

DGGS GMC 279 Publication Details Title: Geochemistry of oil show intervals from ARCO Alaska Inc. Fiord #3 and Fiord #3A Authors: Piggott, Neil, and LGC Geochemistry Publication Date: 1998 Publisher , and LGC Geochemistry, 1998, Geochemistry of oil show intervals from ARCO Alaska Inc. Fiord #3 and

Factors Associated with Successful Learning in Pupils with Dyslexia: A Motivational Analysis

ERIC Educational Resources Information Center

Burden, Robert; Burdett, Julia

2005-01-01

In 2002, Neil Humphrey and Patricia Mullins published their research into personal constructs and attribution for academic success and failure in dyslexia in BJSE's "Research Section". Their work suggested that pupils with dyslexia, in a range of settings, experience real challenges to their self-esteem and that dyslexia leads to "negative…

Proceedings of the Interservice/Industry Training Equipment Conference (4th) Held at Kissimmee, Florida on 15-18 November 1982. Volume 2

DTIC Science & Technology

1982-01-01

Ohio State University Craig , Charles D. 1501 Neil Avenue Training Devices Group Supervisor Columbus, OH 43202 Lockheed California Company P.O. Box...Manager Arlington, VA 22202 Maritime Administration U.S. Merchant Marine Academy Deegan , Paul A. Kingspoint, NY 11024 Editor-Military Simulators

Gemini 8 prime and backup crews during press conference

NASA Image and Video Library

1966-02-26

S66-24380 (26 Feb. 1966) --- Gemini-8 prime and backup crews during press conference. Left to right are astronauts David R. Scott, prime crew pilot; Neil A. Armstrong, prime crew command pilot; Charles Conrad Jr., backup crew command pilot; and Richard F. Gordon Jr., backup crew pilot. Photo credit: NASA

Armstrong Memorial Service

NASA Image and Video Library

2012-09-13

Members of the Cathedral Choirsters sing "For the Beauty of the Earth" during a memorial service celebrating the life of Neil Armstrong at the Washington National Cathedral, Thursday, Sept. 13, 2012. Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit:(NASA/Paul E. Alers)

Armstrong Memorial Service

NASA Image and Video Library

2012-09-13

John H. Dalton, former United States Secretary of the Navy, delivers the Reading during a memorial service celebrating the life of Neil Armstrong at the Washington National Cathedral, Thursday, Sept. 13, 2012. Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Bill Ingalls)

Neurophysiological Research Supporting the Investigation of Adaptive Network Architectures

DTIC Science & Technology

1988-05-01

cadmium . Eur. J. Pharm. 90, 289-292, (1983). p 2, .S PAGE 59 Curriculum Vita Neil E. Berthier April 1983 I• Personal: Born July 1, 1953; Married; SSN...Birt Birth Date: August 20, 1946 Place of Birth: Wabash , Indiana Nationality: U.S. Education: B.S., Purdue University, June 1968. Major: Psychology

Multimedia Landscapes

ERIC Educational Resources Information Center

Sterling, Joan

2009-01-01

In this article, the author describes a culmination activity for a technology unit wherein students would have to create a work of art on the computer that was as artistic as any painting done using oils or acrylics. The painting lesson was based on the song and book, "America the Beautiful," by Katharine Lee Bates and illustrated by Neil Waldman.

Sensory Dysfunction in Early Parkinson’s Disease

DTIC Science & Technology

2011-07-01

Hall, Ph.D., Neil T. Shepard , Ph.D., Allen Osman, Ph.D. 5e. TASK NUMBER E-Mail: doty@mail.med.upenn.edu 5f. WORK UNIT NUMBER 7. PERFORMING...scores of this measure. 4b. Spatial Tactile Sensation JVP domes (Lafayette Instrument Co., Chicago , IL) were used to assess spatial tactile

GEMINI-8 - TRAINING - WATER EGRESS TRAINING - GULF

NASA Image and Video Library

1966-01-15

S66-17288 (15 Jan. 1966) --- Astronauts Neil A. Armstrong (on left), command pilot, and David R. Scott, pilot of the Gemini-8 prime crew, use a boilerplate model of a Gemini spacecraft during water egress training in the Gulf of Mexico. Three Manned Spacecraft Center swimmers assist in the training exercise. Photo credit: NASA

Apollo 11 Technical Air-to-Ground Voice Transcription (GOSS NET 1)

NASA Technical Reports Server (NTRS)

1969-01-01

This is the transcription of the Technical Air-to-Ground Voice Transmission (GOSS NET 1) from the Apollo 11 mission. Communicators in the text may be identified according to the following list [in part]: Commander: Neil A. Armstrong; Command Module Pilot: Michael Collins; Lunar Module Pilot: Edwin E. Aldrin, Jr.

Orion EM-1 Crew Module Adapter Lift & Move to Stand

NASA Image and Video Library

2016-11-11

The Orion crew module adapter (CMA) for Exploration Mission 1 was lifted for the first and only time, Nov. 11, during its processing flow inside the Neil Armstrong Operations and Checkout (O&C) Building high bay at the agency's Kennedy Space Center in Florida. The CMA is now undergoing secondary structure outfitting.

Brain Drain: A Child's Brain on Poverty. Poverty Fact Sheet

ERIC Educational Resources Information Center

Damron, Neil

2015-01-01

"Brain Drain: A Child's Brain on Poverty," released in March 2015 and prepared by intern Neil Damron, explores the brain's basic anatomy and recent research findings suggesting that poverty affects the brain development of infants and young children and the potential lifelong effects of the changes. The sheet draws from a variety of…

Proceedings of the National Technical Literacy Conference (8th, Arlington, Virginia, January 15-17, 1993).

ERIC Educational Resources Information Center

National Association for Science, Technology, and Society, University Park, PA.

This document of conference proceedings is divided into five sections. The first, STS (Science Technology and Society) Studies, contains five papers: (1) "Scientific Discourse and Public Policy" (Jane C. Webb; George R. Webb; Charolette Webb); (2) "An Answer to Neil Postman's 'Technopoly'" (David K. Nations); (3)…

KSC-391c6479-10

NASA Image and Video Library

2000-05-02

Original photo and caption dated October 8, 1991: "Plant researchers Lisa Ruffe and Neil Yorio prepare to harvest a crop of Waldann's Green Lettuce from KSC's Biomass Production Chamber (BPC). KSC researchers have grown several different crops in the BPC to determine which plants will better produce food, water and oxygen on long-duration space missions."

KSC-391c6479-21

NASA Image and Video Library

2000-05-02

Original photo and caption dated October 8, 1991: "Plant researchers Neil Yorio and Lisa Ruffe prepare to harvest a crop of Waldann's Green Lettuce from KSC's Biomass Production Chamber (BPC). KSC researchers have grown several different crops in the BPC to determine which plants will better produce food, water and oxygen on long-duration space missions."

Action Research. Case Studies in TESOL Practice Series.

ERIC Educational Resources Information Center

Edge, Julian, Ed.

Chapter titles in this book include the following: "Attitude and Access: Building a New Teaching/Learning Community in TESOL" (Julian Edge); "Here It Is, Rough Though It May Be: Basic Computer for ESL" (Alison Perkins); "An 'It's Not Action Research Yet, but I'm Getting There' Approach to Teaching Writing" (Neil Cowie); "Early Reflections:…

Updating Board Bylaws: A Guide for Colleges and Universities

ERIC Educational Resources Information Center

O'Neil, Robert M.

2013-01-01

"Updating Board Bylaws: A Guide for Colleges and Universities" represents the latest thinking on good governance in higher education by providing a concise deconstruction of the essential clauses in college, university, and system bylaws. Written by Robert O'Neil, former professor of law and president of the University of Wisconsin System and the…

Apollo 11 Astronaut Neil Armstrong During Lunar Rock Collection Training

NASA Technical Reports Server (NTRS)

1969-01-01

In this photograph, Apollo 11 astronaut Neil A. Armstrong uses a geologist's hammer in selecting rock specimens during a geological field trip to the Quitman Mountains area near the Fort Quitman ruins in far west Texas. Armstrong, alongside astronaut Edwin (Buzz) Aldrin, practiced gathering rock specimens using special lunar geological tools in preparation for the first Lunar landing. Mission was accomplished in July of the same year. Aboard the Marshall Space Fight center (MSFC) developed Saturn V launch vehicle, the Apollo 11 mission launched from The Kennedy Space Center, Florida on July 16, 1969 and safely returned to Earth on July 24, 1969. The 3-man crew aboard the flight consisted of Armstrong, commander; Aldrin, Lunar Module pilot; and a third astronaut Michael Collins, Command Module pilot. Armstrong was the first human to ever stand on the lunar surface, followed by Aldrin, while Collins remained in lunar orbit. The crew collected 47 pounds of lunar surface material which was returned to Earth for analysis. The lunar surface exploration was concluded in 2½ hours.

Revisiting Neil Armstrongs Moon-Landing Quote: Implications for Speech Perception, Function Word Reduction, and Acoustic Ambiguity

PubMed Central

Baese-Berk, Melissa M.; Dilley, Laura C.; Schmidt, Stephanie; Morrill, Tuuli H.; Pitt, Mark A.

2016-01-01

Neil Armstrong insisted that his quote upon landing on the moon was misheard, and that he had said one small step for a man, instead of one small step for man. What he said is unclear in part because function words like a can be reduced and spectrally indistinguishable from the preceding context. Therefore, their presence can be ambiguous, and they may disappear perceptually depending on the rate of surrounding speech. Two experiments are presented examining production and perception of reduced tokens of for and for a in spontaneous speech. Experiment 1 investigates the distributions of several acoustic features of for and for a. The results suggest that the distributions of for and for a overlap substantially, both in terms of temporal and spectral characteristics. Experiment 2 examines perception of these same tokens when the context speaking rate differs. The perceptibility of the function word a varies as a function of this context speaking rate. These results demonstrate that substantial ambiguity exists in the original quote from Armstrong, and that this ambiguity may be understood through context speaking rate. PMID:27603209

Revisiting Neil Armstrongs Moon-Landing Quote: Implications for Speech Perception, Function Word Reduction, and Acoustic Ambiguity.

PubMed

Baese-Berk, Melissa M; Dilley, Laura C; Schmidt, Stephanie; Morrill, Tuuli H; Pitt, Mark A

2016-01-01

Neil Armstrong insisted that his quote upon landing on the moon was misheard, and that he had said one small step for a man, instead of one small step for man. What he said is unclear in part because function words like a can be reduced and spectrally indistinguishable from the preceding context. Therefore, their presence can be ambiguous, and they may disappear perceptually depending on the rate of surrounding speech. Two experiments are presented examining production and perception of reduced tokens of for and for a in spontaneous speech. Experiment 1 investigates the distributions of several acoustic features of for and for a. The results suggest that the distributions of for and for a overlap substantially, both in terms of temporal and spectral characteristics. Experiment 2 examines perception of these same tokens when the context speaking rate differs. The perceptibility of the function word a varies as a function of this context speaking rate. These results demonstrate that substantial ambiguity exists in the original quote from Armstrong, and that this ambiguity may be understood through context speaking rate.

Saturn Apollo Program

NASA Image and Video Library

1989-03-09

The Apollo 11 mission, the first manned lunar mission, launched from the Kennedy Space Center, Florida via the Marshall Space Flight Center (MSFC) developed Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. Aboard the space craft were astronauts Neil A. Armstrong, commander; Michael Collins, Command Module (CM) pilot; and Edwin E. Aldrin Jr., Lunar Module (LM) pilot. The CM, piloted by Michael Collins remained in a parking orbit around the Moon while the LM, named “Eagle’’, carrying astronauts Neil Armstrong and Edwin Aldrin, landed on the Moon. During 2½ hours of surface exploration, the crew collected 47 pounds of lunar surface material for analysis back on Earth. With the success of Apollo 11, the national objective to land men on the Moon and return them safely to Earth had been accomplished. This logo represents the Commemorative 20th Anniversary of the Apollo 11 Lunar mission. Housed inside the zero of the numeral twenty is the original flight insignia in which an Eagle descending upon the lunar surface depicts the LM, named “Eagle’’.

Who will save the tokamak - Harry Potter, Arnold Schwarzenegger, or Shaquille O'Neil?

NASA Astrophysics Data System (ADS)

Freidberg, J.; Mangiarotti, F.; Minervini, J.

2014-10-01

The tokamak is the current leading contender for a fusion power reactor. The reason for the preeminence of the tokamak is its high quality plasma physics performance relative to other concepts. Even so, it is well known that the tokamak must still overcome two basic physics challenges before becoming viable as a DEMO and ultimately a reactor: (1) the achievement of non-inductive steady state operation, and (2) the achievement of robust disruption free operation. These are in addition to the PMI problems faced by all concepts. The work presented here demonstrates by means of a simple but highly credible analytic calculation that a ``standard'' tokamak cannot lead to a reactor - it is just not possible to simultaneously satisfy all the plasma physics plus engineering constraints. Three possible solutions, some more well-known than others, to the problem are analyzed. These visual image generating solutions are defined as (1) the Harry Potter solution, (2) the Arnold Schwarzenegger solution, and (3) the Shaquille O'Neil solution. Each solution will be described both qualitatively and quantitatively at the meeting.

DNA Glycosylases Search for and Remove Oxidized DNA Bases

PubMed Central

Wallace, Susan S.

2014-01-01

The following mini review summarizes recent research from the Author’s laboratory as presented to the Environmental Mutagen Society in October 2012. It provides an overview of the DNA glycosylases that recognize oxidized DNA bases using the Fpg/Nei family of DNA glycosylases as models for how structure can inform function. For example, even though human NEIL1 and the plant and fungal orthologs lack the zinc finger shown to be required for binding, DNA crystal structures revealed a “zincless finger” with the same properties. Also the “lesion recognition loop” is not involved in lesion recognition rather stabilization of 8-oxoG in the active site pocket. Unlike the other Fpg/Nei family members, Neil3 lacks two of the three void-filling residues that stabilize the duplex and interact with the opposite strand which may account for its preference for lesions in single stranded DNA. We also showed, using single molecule approaches, that DNA glycosylases search for their substrates in a sea of undamaged DNA by using a wedge residue that is inserted into the DNA helix to probe for the presence of damage. PMID:24123395

Saturn Apollo Program

NASA Image and Video Library

1969-07-09

In this photograph, technicians are transferring mice from a support germ free isolator, through a hypochlorite dunk tank, into the class III cabinetry in the Germ-free and Conventional Animal Laboratories of the Lunar Receiving Laboratory, building 37, of the Manned Spacecraft Center in Houston, Texas. This laboratory was part of the overall physical, chemical, and biological test program of the Apollo 11 returned lunar samples. Aboard the Marshall Space Flight Center (MSFC) developed Saturn V launch vehicle, the Apollo 11 mission launched from The Kennedy Space Center, Florida on July 16, 1969 and safely returned to Earth on July 24, 1969. The 3-man crew aboard the flight consisted of astronauts Neil A. Armstrong, commander; Edwin Aldrin, Lunar Module (LM) pilot; and Michael Collins, Command Module (CM) pilot. The CM, piloted by Michael Collins remained in a parking orbit around the Moon while the LM, named “Eagle’’, carrying astronauts Neil Armstrong and Edwin Aldrin, landed on the Moon. In 2 1/2 hours, the crew collected 47 pounds of lunar surface material which was returned to Earth for analysis.

A Role for the Fifth G-Track in G-Quadruplex Forming Oncogene Promoter Sequences during Oxidative Stress: Do These "Spare Tires" Have an Evolved Function?

PubMed

Fleming, Aaron M; Zhou, Jia; Wallace, Susan S; Burrows, Cynthia J

2015-08-26

Uncontrolled inflammation or oxidative stress generates electron-deficient species that oxidize the genome increasing its instability in cancer. The G-quadruplex (G4) sequences regulating the c-MYC , KRAS , VEGF , BCL-2 , HIF-1α , and RET oncogenes, as examples, are targets for oxidation at loop and 5'-core guanines (G) as showcased in this study by CO 3 •- oxidation of the VEGF G4. Products observed include 8-oxo-7,8-dihydroguanine (OG), spiroiminodihydantoin (Sp), and 5-guanidinohydantoin (Gh). Our previous studies found that OG and Gh, when present in the four G-tracks of the solved structure for VEGF and c-MY C, were not substrates for the base excision repair (BER) DNA glycosylases in biologically relevant KCl solutions. We now hypothesize that a fifth G-track found a few nucleotides distant from the G4 tracks involved in folding can act as a "spare tire," facilitating extrusion of a damaged G-run into a large loop that then becomes a substrate for BER. Thermodynamic, spectroscopic, and DMS footprinting studies verified the fifth domain replacing a damaged G-track with OG or Gh at a loop or core position in the VEGF G4. These new "spare tire"-containing strands with Gh in loops are now found to be substrates for initiation of BER with the NEIL1, NEIL2, and NEIL3 DNA glycosylases. The results support a hypothesis in which regulatory G4s carry a "spare-tire" fifth G-track for aiding in the repair process when these sequences are damaged by radical oxygen species, a feature observed in a large number of these sequences. Furthermore, formation and repair of oxidized bases in promoter regions may constitute an additional example of epigenetic modification, in this case of guanine bases, to regulate gene expression in which the G4 sequences act as sensors of oxidative stress.

Genetic Diversity of the Flagellin Genes of Clostridium botulinum Groups I and II

PubMed Central

Woudstra, Cedric; Lambert, Dominic; Anniballi, Fabrizio; De Medici, Dario; Austin, John

2013-01-01

Botulinum neurotoxins (BoNTs) are produced by phenotypically and genetically different Clostridium species, including Clostridium botulinum and some strains of Clostridium baratii (serotype F) and Clostridium butyricum (serotype E). BoNT-producing clostridia responsible for human botulism encompass strains of group I (secreting proteases, producing toxin serotype A, B, or F, and growing optimally at 37°C) and group II (nonproteolytic, producing toxin serotype E, B, or F, and growing optimally at 30°C). Here we report the development of real-time PCR assays for genotyping C. botulinum strains of groups I and II based on flaVR (variable region sequence of flaA) sequences and the flaB gene. Real-time PCR typing of regions flaVR1 to flaVR10 and flaB was optimized and validated with 62 historical and Canadian C. botulinum strains that had been previously typed. Analysis of 210 isolates of European origin allowed the identification of four new C. botulinum flaVR types (flaVR11 to flaVR14) and one new flaVR type specific to C. butyricum type E (flaVR15). The genetic diversity of the flaVR among C. botulinum strains investigated in the present study reveals the clustering of flaVR types into 5 major subgroups. Subgroups 1, 3, and 4 contain proteolytic Clostridium botulinum, subgroup 2 is made up of nonproteolytic C. botulinum only, and subgroup 5 is specific to C. butyricum type E. The genetic variability of the flagellin genes carried by C. botulinum and the possible association of flaVR types with certain geographical areas make gene profiling of flaVR and flaB promising in molecular surveillance and epidemiology of C. botulinum. PMID:23603687

Structural Characterization of the Fla2 Flagellum of Rhodobacter sphaeroides

PubMed Central

de la Mora, Javier; Uchida, Kaoru; del Campo, Ana Martínez; Camarena, Laura; Aizawa, Shin-Ichi

2015-01-01

ABSTRACT Rhodobacter sphaeroides is a free-living alphaproteobacterium that contains two clusters of functional flagellar genes in its genome: one acquired by horizontal gene transfer (fla1) and one that is endogenous (fla2). We have shown that the Fla2 system is normally quiescent and under certain conditions produces polar flagella, while the Fla1 system is always active and produces a single flagellum at a nonpolar position. In this work we purified and characterized the structure and analyzed the composition of the Fla2 flagellum. The number of polar filaments per cell is 4.6 on average. By comparison with the Fla1 flagellum, the prominent features of the ultra structure of the Fla2 HBB are the absence of an H ring, thick and long hooks, and a smoother zone at the hook-filament junction. The Fla2 helical filaments have a pitch of 2.64 μm and a diameter of 1.4 μm, which are smaller than those of the Fla1 filaments. Fla2 filaments undergo polymorphic transitions in vitro and showed two polymorphs: curly (right-handed) and coiled. However, in vivo in free-swimming cells, we observed only a bundle of filaments, which should probably be left-handed. Together, our results indicate that Fla2 cell produces multiple right-handed polar flagella, which are not conventional but exceptional. IMPORTANCE R. sphaeroides possesses two functional sets of flagellar genes. The fla1 genes are normally expressed in the laboratory and were acquired by horizontal transfer. The fla2 genes are endogenous and are expressed in a Fla1− mutant grown phototrophically and in the absence of organic acids. The Fla1 system produces a single lateral or subpolar flagellum, and the Fla2 system produces multiple polar flagella. The two kinds of flagella are never expressed simultaneously, and both are used for swimming in liquid media. The two sets of genes are certainly ready for responding to specific environmental conditions. The characterization of the Fla2 system will help us to understand its role in the physiology of this microorganism. PMID:26124240

Armstrong Memorial Service

NASA Image and Video Library

2012-09-13

Apollo 17 mission commander Gene Cernan, the last man to walk on the moon, looks skyward during a memorial service celebrating the life of Neil Armstrong at the Washington National Cathedral, Thursday, Sept. 13, 2012. Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Bill Ingalls)

Armstrong Memorial Service

NASA Image and Video Library

2012-09-13

Apollo 17 mission commander Gene Cernan, the last man to walk on the moon, speaks during a memorial service celebrating the life of Neil Armstrong at the Washington National Cathedral, Thursday, Sept. 13, 2012. Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Bill Ingalls)

Armstrong Memorial Service

NASA Image and Video Library

2012-09-13

Apollo 17 astronaut Gene Cernan, the last man to walk on the moon, speaks during a memorial service celebrating the life of Neil Armstrong at the Washington National Cathedral, Thursday, Sept. 13, 2012. Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Paul E. Alers)

Activation of Operational Thinking during Arithmetic Practice Hinders Learning and Transfer

ERIC Educational Resources Information Center

Chesney, Dana L.; McNeil, Nicole M.

2014-01-01

Many children in the U.S. initially come to understand the equal sign operationally, as a symbol meaning "add up the numbers" rather than relationally, as an indication that the two sides of an equation share a common value. According to a change-resistance account (McNeil & Alibali, 2005b), children's operational ways of thinking…

Apollo 11 crewmen released from quarantine

NASA Image and Video Library

1969-08-07

Astronaut Neil A. Armstrong (center), is greeted by friends in the crew reception area of the Lunar Receiving Laboratory. Dr. Gilruth is pictured just to right of Armstrong. Donald K. Slayton, Director of Space Flight Crew Operations, is behind ArmstrongThe Apollo 11 crew left the crew reception area of the Lunar Receiving Laboratory at 9 p.m., Aug. 10, 1969.

Fatal Amusements: Contemplating the Tempest of Contemporary Media and American Culture

ERIC Educational Resources Information Center

Strate, Lance

2016-01-01

Our use of the electronic media to conduct serious discourse raises the question of whether "we are amusing ourselves to death," as Neil Postman argued. The approach known as "media ecology," the study of media as environments, which emphasizes the need to understand context and find balance, provides a basis for the analysis…

View of Mission Control Center (MCC) - Lunar Surface - Apollo XI - Extravehicular Activity (EVA) - MSC

NASA Image and Video Library

1969-07-20

S69-39817 (20 July 1969) --- Interior view of the Mission Operations Control Room (MOCR) in the Mission Control Center (MCC), Building 30, during the Apollo 11 lunar extravehicular activity (EVA). The television monitor shows astronauts Neil A. Armstrong and Edwin E. Aldrin Jr. on the surface of the moon.

Why There Are No Conservative Professors and Why Do Conservatives Care: Implications for Christian Scholarship

ERIC Educational Resources Information Center

Brow, Mark V.

2017-01-01

The dearth of conservative professors in many disciplinary fields in higher education has been the concern, oddly enough, of liberal scholars. Perhaps one of the most prolific apologists of the liberal professorate has been professor of sociology Neil Gross at the University of British Columbia. Gross attributes the abundance of liberal professors…

Ten Year Revision of the Brief Behavioral Activation Treatment for Depression: Revised Treatment Manual

ERIC Educational Resources Information Center

Lejuez, C. W.; Hopko, Derek R.; Acierno, Ron; Daughters, Stacey B.; Pagoto, Sherry L.

2011-01-01

Following from the seminal work of Ferster, Lewinsohn, and Jacobson, as well as theory and research on the Matching Law, Lejuez, Hopko, LePage, Hopko, and McNeil developed a reinforcement-based depression treatment that was brief, uncomplicated, and tied closely to behavioral theory. They called this treatment the brief behavioral activation…

Algorithm for Automatic Detection, Localization and Characterization of Magnetic Dipole Targets Using the Laser Scalar Gradiometer

DTIC Science & Technology

2016-06-01

TECHNICAL REPORT Algorithm for Automatic Detection, Localization and Characterization of Magnetic Dipole Targets Using the Laser Scalar...Automatic Detection, Localization and Characterization of Magnetic Dipole Targets Using the Laser Scalar Gradiometer Leon Vaizer, Jesse Angle, Neil...of Magnetic Dipole Targets Using LSG i June 2016 TABLE OF CONTENTS INTRODUCTION

50th Anniversary First American to Orbit Earth

NASA Image and Video Library

2012-02-20

Sen. John Glenn, left, and Apollo 11 Astronaut Neil Armstrong are seen prior to the start of a dinner at Ohio State University that honored the 50th anniversary of John Glenn's historic flight aboard Friendship 7 Monday, Feb. 20, 2012, in Columbus, Ohio. Glenn was the first American to orbit Earth. Photo Credit: (NASA/Bill Ingalls)

Q&A: The space crusader

NASA Astrophysics Data System (ADS)

Cowen, Ron

2014-05-01

US astronomer Neil deGrasse Tyson, director of New York's Hayden Planetarium, currently hosts the television series Cosmos -- an update of Carl Sagan's 1980 show -- broadcast in 181 countries and 45 languages. As it winds down, Tyson talks about the rich mix of science and pop culture, the 'neurosynaptic snapshot' of public responses to his tweets, and his momentous meeting with Sagan.

The Presence of the Past: History "For" and "Against" Minorities.

ERIC Educational Resources Information Center

Clearinghouse for Civil Rights Research, 1980

1980-01-01

In this paper, the subject of bias in historical materials is examined. Three articles and two reviews are presented. The articles are: (1) "How Multicultural Educational Materials Affect Children," by Neil J. Kressel and James W. Loewen; (2) "Pluralist History and Public Relations History," by James W. Loewen; and (3) "Televised History and Race…

Ground Rules for Talk: The Acceptable Face of Prescription

ERIC Educational Resources Information Center

Lambirth, Andrew

2009-01-01

In this second article on the theory of "ground rules for talk" I extend a debate between myself and Professor Neil Mercer over the introduction of "ground rules" into classrooms. I critique ground rules through the use of sociological theory and argue that advocates of the ground rules perspective need to recognise the ideological nature of their…

Meeting the Needs of Able Learners through Flexible Pacing. ERIC Digest #464.

ERIC Educational Resources Information Center

ERIC Clearinghouse on Handicapped and Gifted Children, Reston, VA.

This information sheet, based on "Flexible Pacing for Able Learners" by Neil Daniel and June Cox, defines flexible pacing as any program in which students are taught material that is appropriately challenging for their ability and allows them to move forward in the curriculum as they master content and skill. The document outlines…

Apollo 11 Facts Project [EVA Training/Washington, D. C. Tour

NASA Technical Reports Server (NTRS)

1994-01-01

Footage shows the crew of Apollo 11, Commander Neil Armstrong, Lunar Module Pilot Edwin Aldrin Jr., and Command Module Pilot Michael Collins, during various pre-mission activities. They are seen training for the extravehicular activity on the surface of the Moon, giving speeches in front of the White House, and during a parade in Houston.

Research Planning Conference on Language Development in Disadvantaged Children, June 7-8, 1966.

ERIC Educational Resources Information Center

Yeshiva Univ., New York, NY. Graduate School of Education.

These proceedings contain six conference papers with commentary and discussion: (1) Dell Hymes, "On Communicative Competence," (2) David McNeill, "How to Learn a First Language," (3) Wayne O'Neil, "A Theory of Linguistic Performance," (4) William Stewart, "Social Dialect," (5) Paul Cohen, "Some Methods in Sociolinguistic Research," and (6) S. Alan…

Does Implementing an Emotional Intelligence Program Guarantee Student Achievement?

ERIC Educational Resources Information Center

Wilkens, Coral L.; Wilmore, Elaine

2015-01-01

Being a 21st century learner may require a shift in the education paradigm. To be successful students may need to possess a different type of intelligence. Cherniss (2001), Goleman (1995), and O'Neil (1996), suggest that the key to positive life outcomes might consider emotional intelligence as more important than intellectual quotient (IQ).…

The Gender Role Conflict Literature: Fruits of Sustained Commitment

ERIC Educational Resources Information Center

Heppner, P. Paul; Heppner, Mary J.

2008-01-01

Twenty-five years ago, when the men's movement was in its beginning stages, O'Neil recognized the importance of understanding more about the impact of men's gender role conflict. This ensuing quarter century of research has produced a much more nuanced and sophisticated understanding of gender role conflict than we had then. In his integrative…

Jazz Leader Helps a Band Take Giant Steps

ERIC Educational Resources Information Center

Kelderman, Eric

2008-01-01

This article profiles Neil Slater, the longtime leader of the jazz program at the University of North Texas who encouraged both musical perfection and artistic freedom among his star pupils. Standards are high at North Texas, which has become a Camelot where aspiring jazz musicians have come to hone their skills since 1947, when it offered one of…

GEMINI-TITAN-8 - TRAINING - WATER EGRESS

NASA Image and Video Library

1966-01-15

S66-17253 (15 Jan. 1966) --- Astronauts Neil A. Armstrong (center), command pilot, and David R. Scott (right), pilot of the Gemini-8 prime crew, are suited up for water egress training aboard the NASA Motor Vessel Retriever in the Gulf of Mexico. At left is Dr. Kenneth N. Beers, M.D., Flight Medicine Branch, Center Medical Office. Photo credit: NASA

Armstrong Memorial Service

NASA Image and Video Library

2012-09-13

Former U.S. Sen. John Glenn, left, and musician Diana Krall bow there heads in prayer during a memorial service celebrating the life of Neil Armstrong, Thursday, Sept. 13, 2012, at the Washington National Cathedral. Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Bill Ingalls)

Views of the Apollo 11 Twentieth Anniversary Black Tie reception

NASA Technical Reports Server (NTRS)

1989-01-01

Views of the Apollo 11 Twentieth Anniversary Black Tie reception at the downtown Houston Hyatt Regency Hotel. Views include former JSC Directors Robert Gilruth and Christopher C. Kraft Jr. reminiscing with keynote speaker Walter Cronkite (39934); Apollo astronauts Tom Stafford (left) and Neil Armstrong (right) talk with former Soviet cosmonaut Alexei Leonov (center) at the gala (39935).

Thinking Complexly about Men, Gender Role Conflict, and Counseling Psychology

ERIC Educational Resources Information Center

Wester, Stephen R.

2008-01-01

O'Neil (2008) defines male gender role conflict (GRC) as a psychological state in which the socialized male gender role has negative consequences for the person or others. Building on this, many now realize that the mechanisms through which these negative consequences occur, rather than being global, are instead contextual. That is, different men…

Teacher Educator Identity Emerging through Positioning Self and Others

ERIC Educational Resources Information Center

Pinnegar, Stefinee; Murphy, M. Shaun

2011-01-01

Research exploring the process of becoming a teacher educator always reveals the difficult balancing act that developing an identity as a teacher educator involves and the articles in this issue do just that. The Rice and McNeil studies of teacher educator identity in this issue are very revealing; they were conducted from the perspective of…

The Leader's Leader: Examining the HR Executive's Role as Performance Coach at the Management Level

ERIC Educational Resources Information Center

Strodel, Neil; Novak, Christopher

2005-01-01

Higher education human resource professionals know the importance of performance management and coaching for university employees. However, the standards of performance often are not enforced to those in high-level positions. Neil Strodel and Christopher Novak examine how HR leaders are in a unique position to extend performance coaching to those…

Graphical Man/Machine Communications

DTIC Science & Technology

1972-12-01

several others. The principal accomplishments are the development of a homomorphic imane deblurring method by E. Randolph Cole, the research into human...visual modelling by Patrick Baudelair, the impressive demonstrations of background noise elimination by Neil J. Miller, and the innovation of...characteristics for the homomorphical ly estimated restoration filter in the presence of additive noise were derived, and they show that the

Teaching Literature Overseas. Language-Based Approaches. ELT Documents 115. First Edition.

ERIC Educational Resources Information Center

Brumfit, C. J., Ed.

A collection of papers concerning the application of language studies to the instruction and promotion of English literature appreciation in foreign countries includes an introduction by Neil Gilroy-Scott and these essays: "The Deviant Language of Poetry" (H. G. Widdowson); "Approaches to the Study of Literature: A Practitioner's View" (H. L. B.…

10 Years of Media Literacy Education in K-12 Schools

ERIC Educational Resources Information Center

Daunic, Rhys

2011-01-01

When the author started working with teachers and students on classroom multimedia productions a little over 10 years ago, he had not yet encountered the term "media literacy", nor did he realize he had joined a long standing international movement of media literacy educators. Serendipitous exposure to "old-media" texts by Neil Postman and Noam…

The Unaffiliated Unite

ERIC Educational Resources Information Center

Lim, Victoria

2011-01-01

Neil Carter of Ridgeland, Miss., is about to take a leap of faith--based on his lack of faith. In a state where 91 percent of residents say they believe in God "with absolute certainty," according to the Pew Research Center, Carter began "coming out" recently to friends as an atheist. The 41-year-old special education teacher is also exploring…

Identification of a second flagellin gene and functional characterization of a sigma70-like promoter upstream of a Leptospira borgpetersenii flaB gene.

PubMed

Lin, Min; Dan, Hanhong; Li, Yijing

2004-02-01

Leptospira borgpetersenii, one of the causative agents of leptospirosis in both animals and humans, is a bacterial pathogen with characteristic motility that is mediated by the rotation of two periplasmic flagella (PF). The flaB gene coding for a core polypeptide subunit of PF was previously characterized by sequence analysis of its open reading frame (ORF) (M. Lin, J Biochem Mol Biol Biophys 2:181-187, 1999). The present study was undertaken to isolate and clone the uncharacterized sequence upstream of the flaB gene by using a PCR-based genome walking procedure. This has resulted in a 1470-bp genomic DNA sequence in which an 846-bp ORF coding for a 281-amino acid polypeptide (31.3 kDa) is identified 455 bp upstream from the flaB start codon. The encoded protein exhibits 72% amino acid identity to the deduced FlaB protein sequence of L. borgpetersenii and a high degree of sequence homology to the FlaB proteins of other spirochaetes. This has demonstrated for the first time that a second flaB gene homolog is present in a Leptospira species. The newly identified gene is designated flaB1, and the previously cloned flaB renamed flaB2. Within the intergenic sequence between flaB1 and flaB2, a potential stem-loop structure (12-bp inverted repeats) was identified 25 bp downstream of the flaB1 stop codon; this could serve as a transcription terminator for the flaB1 mRNA. Three E. coli-like promoter regions (I, II, and III) for binding Esigma(70), a regulatory sequence uncommonly found in flagellar genes, were predicted upstream of the flaB2 ORF. Only promoter region II contains a promoter that is functional in E. coli, as revealed at phenotypic and transcriptional levels by its capability of directing the expression of the chloramphenicol acetyltransferase (CAT) gene in the promoter probe vector pKK232-8. These observations may suggest that flaB1 and flaB2 are transcribed separately and do not form a transcriptional operon controlled by a single promoter.

Evaluation of FlaB1, FlaB2, FlaB3, and Tp0463 of Treponema pallidum for serodiagnosis of syphilis.

PubMed

Jiang, Chuanhao; Xiao, Jinhong; Xie, Yafeng; Xiao, Yongjian; Wang, Chuan; Kuang, Xingxing; Xu, Man; Li, Ranhui; Zeng, Tiebing; Liu, Shuanquan; Yu, Jian; Zhao, Feijun; Wu, Yimou

2016-02-01

Syphilis is a multistage disease caused by the invasive spirochete Treponema pallidum subsp. pallidum, and accurate diagnosis is important for the prevention and treatment of syphilis. Here, to identify appropriate diagnostic antigens for serodiagnosis of syphilis, 6 recombinant proteins were expressed in Escherichia coli and purified, including flagellins (FlaB1 [Tp0868], FlaB2 [Tp0792], and FlaB3 [Tp0870]), Tp0463, Tp0751, and Tp1038. The sensitivities were determined by screening sera from individuals with primary (n=82), secondary (n=115), latent (n=105), and congenital (n=65) syphilis. The specificities were determined by screening sera from uninfected controls (n=30) and potentially cross-reactive infections including Lyme disease (n=30), leptospirosis (n=5), and hepatitis B (n=30). Our data showed that FlaB1, FlaB2, FlaB3, Tp0463, and Tp1038 exhibited higher overall sensitivities and specificities for detecting IgG antibody, with 95.4% and 98.9%, 92.6% and 95.8%, 95.1% and 95.8%, 92.6% and 97.9%, and 95.9% and 98.9%, respectively. In contrast, Tp0751 demonstrated only an overall sensitivity of 39.2%. For comparison, the sensitivity and specificity of Architect Syphilis TP were determined to be 98.1% and 93.7%, respectively. In addition, FlaB1, FlaB2, FlaB3, and Tp0463 demonstrated excellent performance for detecting IgM antibody in primary and congenital syphilis, with sensitivities of 76.8% and 83.1%, 72.0% and 87.7%, 74.4% and 89.2%, and 64.6% and 75.3%, respectively. These results indicate that FlaB1, FlaB2, FlaB3, and Tp0463 could be as novel diagnostic candidates for serodiagnosis of syphilis. Copyright © 2016 Elsevier Inc. All rights reserved.

Why Liberal State Funding of Denominational Schools Cannot be Unconditional: A Reply to Neil Burtonwood

ERIC Educational Resources Information Center

Snik, Ger; De Jong, Johan

2005-01-01

In this article we take up Burtonwood's criticism of our view that liberal states should, under certain conditions, fund denominational schools. We not only reject his plea for the accommodation of strong faith schools by liberalism but also criticise his portrayal of the character of the conflict between liberals and strong faith school…

Portrait of seven original Mercury astronauts plus new members

NASA Technical Reports Server (NTRS)

1963-01-01

Portrait of the seven original Mercury astronauts plus new members of the astronaut corps. Seated from left to right are: Gordon Cooper, Gus Grissom, Scott Carpenter, Wally Schirra, John Glenn, Alan Shepard, and Deke Slayton. Standing from left to right are: Edward White, James McDivitt, John Young, Elliot See, Charles Conrad, Frank Borman, Neil Armstrong, Thomas Stafford, and James Lovell.

The Restoration of an Ilkak'mana: A Chief Called Multnomah

ERIC Educational Resources Information Center

Fulton, Ann

2007-01-01

An ilkak'mana called Multnomah once lived near the river where New England merchants chopped Portland, Oregon, out of a Douglas-fir forest. With a bow and shield slung behind his back, the chief stood imperiously in Hermon A. MacNeil's 1904 statuette inscribed at its base with his name. Nearby tribes preserved Multnomah in words, but years later…

Setting Priorities for Graduate Medical Education,

DTIC Science & Technology

1996-02-01

assist the work of these staffs. 14. SUBJECT TERMS Attrition, data bases, education , mathematical models, medical personnel, military medicine, naval...CRM 95-209 / February 1996 Setting Priorities for Graduate Medical Education Neil B. Carey • Marjorie D. Curia • Oliver A. Smith 19960718 027...the tirae for reviewing instructions, searching existing data sources gathering and maintaining the data needed, and reviewing the collection of

Orion Crew Module Structural Test Article Arrival

NASA Image and Video Library

2016-11-14

NASA’s Super Guppy aircraft arrives on the tarmac after touching down at the Shuttle Landing Facility at the agency’s Kennedy Space Center in Florida. The guppy is carrying the Orion crew module structural test article (STA). The STA will be offloaded and transported to the Neil Armstrong Operations and Checkout Building high bay for further testing. Photo credit: NASA/Kim Shiflett

LUNAR SAMPLES - APOLLO 11

NASA Image and Video Library

1969-08-03

S69-40749 (July 1969) --- Dr. Grant Heikan, MSC and a Lunar Sample Preliminary Examination Team member, examines lunar material in a sieve from the bulk sample container which was opened in the Biopreparation Laboratory of the Lunar Receiving Laboratory. The samples were collected by astronauts Neil A. Armstrong and Edwin E. Aldrin Jr. during their lunar surface extravehicular activity on July 20, 1969.

Viewing Extensive Reading from Different Vantage Points

ERIC Educational Resources Information Center

Stoller, Fredricka L.

2015-01-01

Some years ago (in about 2007), this author was asked by Professor Neil J. Anderson, known for his expertise in second language (L2) reading, to identify his top-five priorities for teachers of L2 reading. As it turns out, it was an interesting intellectual exercise to narrow down key issues in teaching L2 reading to a grand total of five. To…

KSC-97pc584

NASA Image and Video Library

1997-04-04

Apollo 11 Commander Neil A. Armstrong and his wife, Carol, were among the many special NASA STS-83 launch guests who witnessed the liftoff of the Space Shuttle Columbia April 4 at the Banana Creek VIP Viewing Site at KSC. Columbia took off from Launch Pad 39A at 2:20:32 p.m. EST to begin the 16-day Microgravity Science Laboratory-1 (MSL-1) mission

Deconstructing the Metanarrative of the 21st Century Skills Movement

ERIC Educational Resources Information Center

Greenlaw, Jim

2015-01-01

If Neil Postman, were alive today, what would he say to Prensky, the originator of the term, "digital native", about the ways in which teachers should approach the wonders and perils of e-learning in their classrooms? As the Dean of a faculty of education which is devoted to both creating and critiquing a variety of digital teaching and…

The End(s) of Advocacy: Responding to Our Own Mandates Instead of Creating New Leadership

ERIC Educational Resources Information Center

Cee, Vincent

2013-01-01

In this paper Vincent Cee provides a synthesis of ideas published by several authors who wrote in the late 1960s through the early 1980s. Remarkably, these authors arrived at similar conclusions in disparate ways and disciplines, all of which hold rich implications for music education. The works examined include Neil Postman's and Charles…

Former Spencer Artillery Range, Tennessee Classification Demonstration Open Field and Dynamic Areas

DTIC Science & Technology

2016-01-01

DEMONSTRATION REPORT Former Spencer Artillery Range, Tennessee Classification Demonstration Open Field and Dynamic Areas ESTCP...AVAILABILITY STATEMENT 13. SUPPLEMENTARY NOTES 14. ABSTRACT 15. SUBJECT TERMS 16. SECURITY CLASSIFICATION OF: a. REPORT b. ABSTRACT c. THIS PAGE 17...2016 Technical Report N/A Former Spencer Artillery Range, Tennessee Classification Demonstration Open Field and Dynamic Areas Richard MacNeil, USA

Armstrong, Neil Alden (1930-)

NASA Astrophysics Data System (ADS)

Murdin, P.

2000-11-01

Astronaut, born in Auglaize County, OH, trained as a pilot (Korean War). He flew on Gemini 8 and in 1969, with Michael Collins and EDWIN ALDRIN, took Apollo 11 to the Moon. On 21 July 1969, at 02:56 GMT, Armstrong became the first man to walk on the Moon, with the famous statement, 'That's one small step for a man, one giant leap for mankind'....

PIN - APOLLO 11

NASA Image and Video Library

1969-08-05

S69-40941 (July 1969) --- This picture is of the gold replica of an olive branch, the traditional symbol of peace, which was left on the moon's surface by Apollo 11 crewmembers. Astronaut Neil A. Armstrong, commander, was in charge of placing the small replica (less than half a foot in length) on the moon. The gesture represents a fresh wish for peace for all mankind.

Apollo 11 Facts Project [On-Orbit Lunar Module Checkout

NASA Technical Reports Server (NTRS)

1994-01-01

Footage is shown of the crew of Apollo 11 (Commander Neil Armstrong, Lunar Module Pilot Edwin Aldrin Jr., and Command Module Pilot Michael Collins) inside the spacecraft as they fly from the Earth to the Moon. The Moon is seen in its entirety and in close detail. Aldrin gives a brief demonstration on how the astronauts eat in space.

Recurrent nova M31N 2008-12a: The 2017-eruption X-ray turn-off seen by Swift/XRT

NASA Astrophysics Data System (ADS)

Henze, M.; Darnley, M. J.; Shafter, A. W.; Kafka, S.; Kato, M.; Williams, S. C.; et al.

2018-01-01

The detection of supersoft X-ray source (SSS) emission from the 2017 eruption (ATel #11116) of the rapidly recurring nova M31N 2008-12a (Henze et al. 2014, 2015a, 2015b; Darnley et al. 2014, 2015, 2016) with the Neil Gehrels Swift observatory was announced in ATel #11130.

Self-Directed and Incidental Learning. Symposium 26. [Concurrent Symposium Session at AHRD Annual Conference, 2000.

ERIC Educational Resources Information Center

2000

This packet contains three papers on self-directed and incidental learning from a symposium on human resource development (HRD). The first paper, "Self-Directed Learning for Supervisory Development" (Judy O'Neil, Maria Lamattina), reports on a study that looks at what research says needs to be in place to engage workers in self-directed learning…

President Obama Meets with Crew of Apollo 11

NASA Image and Video Library

2014-07-22

President Barack Obama meets with Apollo 11 astronauts Michael Collins, seated left, Buzz Aldrin, center, Carol Armstrong, widow of Apollo 11 commander, Neil Armstrong, and NASA Administrator Charles Bolden, Tuesday, July 22, 2014, in the Oval Office of the White House in Washington, during the 45th anniversary week of the Apollo 11 lunar landing. Photo Credit: (NASA/Bill Ingalls)

NoSQL Data Store Technologies

DTIC Science & Technology

2014-09-01

NoSQL Data Store Technologies John Klein, Software Engineering Institute Patrick Donohoe, Software Engineering Institute Neil Ernst...REPORT TYPE N/A 3. DATES COVERED 4. TITLE AND SUBTITLE NoSQL Data Store Technologies 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT...distribute data 4. Data Replication – determines how a NoSQL database facilitates reliable, high performance data replication to build

To redesignate the Dryden Flight Research Center as the Neil A. Armstrong Flight Research Center and the Western Aeronautical Test Range as the Hugh L. Dryden Aeronautical Test Range.

THOMAS, 112th Congress

Rep. McCarthy, Kevin [R-CA-22

2012-11-29

Senate - 01/01/2013 Received in the Senate and Read twice and referred to the Committee on Commerce, Science, and Transportation. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

NATO Regional Capacity Building: The Foundation for Success in the Counter-Piracy Campaign

DTIC Science & Technology

2011-04-16

could best tailor 68 Nana K. Poku, Neil Renwick, and Joao Gomes Porto, “Human Security and...be established for 79 Alberto Bin, “NATO’s Mediterranean dialogue,” in The Future of the...nations. 81 Alberto Bin, “NATO’s Mediterranean dialogue,” in The Future of the Euro-Mediterranean Security Dialogue, ed. Martin Ortega (Paris

Effects of Weave Styles and Crimp Gradients on Damage Tolerance and Energy-Absorption Capacities of Woven Kevlar/Epoxy Composites

DTIC Science & Technology

2015-09-01

Technology Office ( Neil J. Dubois (00T1)) and the Office of Naval Research. The principal investigator was Paul V. Cavallaro (Code 7023). The...Office (RDRL-RO-EN (D. Stepp, W. Mullins)) 2 Navy Clothing and Textile Research Facility, Natick, MA (B. Avellini, L. Caulfield, T. Hart, C. Heath

Assessing and Evaluating Department of Defense Efforts to Inform, Influence, and Persuade: An Annotated Reading List

DTIC Science & Technology

2015-01-01

reading, but the read- ings in this section may be given a lower priority. Paul W. Farris, Neil T. Bendle, Phillip E. Pfeifer, and David J. Reibstein...inform, influence, and persuade. Chip Heath and Dan Heath , Made to Stick: Why Some Ideas Survive and Others Die, New York: Random House, 2007. This

Department of Defense and Department of State Planning and Coordination Efforts in West Africa

DTIC Science & Technology

2016-06-10

www.acsscommunity.org. 37 the U.S. had new initiatives: (1) Train as many as 500 health care workers a week, (2) Erect 17 heath care facilities in Liberia of 100...Kollie K. Karsor, C. Sanford Wesseh, Sonpon Sieh, Alex Gasasira, Peter Graaff, Lisa Hensley, Hans Rosling, Terrence Lo, Satish K. Pillai, Neil Gupta

OBSANP Data Acquisition System: Operator’s Manual and System Overview

DTIC Science & Technology

2013-10-01

SN  11  –  updated  TCR  from  Arlie  Farlie  during  expedition   52   Figure  28.     Octopus  Wiring  Diagram...Operator’s Manual and System Overview Page 53 of 54 Figure 28. Octopus Wiring Diagram / Neil McPhee (WHOI) WHOI-2013-06 OBSANP Data Acquisition

No Place to Call Home: Child & Youth Homelessness in the United States. Poverty Fact Sheet

ERIC Educational Resources Information Center

Damron, Neil

2015-01-01

"No Place to Call Home: Child and Youth Homelessness in the United States," prepared by intern Neil Damron and released in May 2015, presents the statistics on child and youth homelessness and recent trends in Wisconsin and the United States. It explores the major challenges faced by homeless minors, and, drawing from recent research by…

Armstrong Memorial Service

NASA Image and Video Library

2012-09-13

Apollo 11 command module pilot Michael Collins is framed by the upraised Bible held by the Rev. Gina Gilland Campbell during a memorial service celebrating the life of Neil Armstrong at the Washington National Cathedral, Thursday, Sept. 13, 2012. Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Bill Ingalls)

A Cognitive Approach to COIN: Countering Dangerous Beliefs

DTIC Science & Technology

2009-05-13

College 686 Cushing Road Newport, RI 02841-1207 9. SPONSORING/MONITORING AGENCY NAME( S ) AND ADDRESS(ES...CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR( S ) 5d. PROJECT NUMBER...Jeffrey A. McNeil, Maj, USA 5e. TASK NUMBER Paper Advisor: Dr. Donald Chisholm 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME( S ) AND

EFFECT OF INHALED ENDOTOXIN ON AIRWAY AND CIRCULATING INFLAMMATORY CELL PHAGOCYTOSIS AND CD11B EXPRESSION IN ATOPIC ASTHMATIC SUBJECTS

EPA Science Inventory

Effect of inhaled endotoxin on airway and circulating inflammatory cell phagocytosis and CD11b expression in atopic asthmatic subjects

Neil E. Alexis, PhD, Marlowe W. Eldridge, MD, David B. Peden, MD, MS

Chapel Hill and Research Triangle Park, NC

Backgrou...

n/a

NASA Image and Video Library

1969-07-25

The Apollo 11 mission, the first manned lunar mission, launched aboard the Saturn V launch vehicle from the Kennedy Space Center, Florida on July 16, 1969 and safely returned to Earth on July 24, 1969. Aboard were astronauts Neil A. Armstrong, commander; Michael Collins, Command Module (CM) pilot; and Edwin E. Aldrin Jr., Lunar Module (LM) pilot. The CM, piloted by Michael Collins, remained in a parking orbit around the Moon while the LM, named “Eagle’’, carrying astronauts Neil Armstrong and Edwin Aldrin, landed on the Moon. Armstrong was the first human to ever stand on the lunar surface, followed by Edwin (Buzz) Aldrin. The surface exploration was concluded in 2½ hours. Once the crew collected 47 pounds of lunar surface material for analysis back on Earth, the LM redocked with the CM for the crew’s return to Earth. Following splash down in the Pacific Ocean, Navy para-rescue men recovered the capsule housing the 3-man crew. The crew was airlifted to safety aboard the U.S.S. Hornet, where they were quartered in a Mobile Quarantine Facility (MQF). Astronaut Collins took this snapshot of astronauts Armstrong (center) and Aldrin inside of the MQF.

Saturn Apollo Program

NASA Image and Video Library

1969-07-09

In preparation of the nation’s first Lunar landing mission, Apollo 11 crew members underwent training activities to practice activities they would be performing during the mission. In this photograph, Neil Armstrong, donned in his space suit, practices getting back to the first rung of the ladder on the Lunar Module (LM). The Apollo 11 mission launched from the Kennedy Space Center (KSC) in Florida via the Marshall Space Flight Center (MSFC) developed Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. Aboard the space craft were astronauts Neil A. Armstrong, commander; Michael Collins, Command Module (CM) pilot; and Edwin E. (Buzz) Aldrin Jr., Lunar Module (LM) pilot. The CM, “Columbia”, piloted by Collins, remained in a parking orbit around the Moon while the LM, “Eagle’’, carrying astronauts Armstrong and Aldrin, landed on the Moon. On July 20, 1969, Armstrong was the first human to ever stand on the lunar surface, followed by Aldrin. During 2½ hours of surface exploration, the crew collected 47 pounds of lunar surface material for analysis back on Earth. With the success of Apollo 11, the national objective to land men on the Moon and return them safely to Earth had been accomplished.

Saturn Apollo Program

NASA Image and Video Library

1969-07-20

This is a detailed view of the back side of Moon in the vicinity of Crater No. 308 taken during the Apollo 11 mission. Apollo 11, the first manned lunar mission, launched from The Kennedy Space Center, Florida via a Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. The Saturn V vehicle was developed by the Marshall Space Flight Center (MSFC) under the direction of Dr. Wernher von Braun. The 3-man crew aboard the flight consisted of Neil A. Armstrong, commander; Michael Collins, Command Module pilot; and Edwin E. Aldrin Jr., Lunar Module pilot. The Lunar Module (LM), named “Eagle, carrying astronauts Neil Armstrong and Edwin Aldrin, was the first crewed vehicle to land on the Moon. Meanwhile, astronaut Collins piloted the Command Module in a parking orbit around the Moon. Armstrong was the first human to ever stand on the lunar surface, followed by Edwin (Buzz) Aldrin. The crew collected 47 pounds of lunar surface material which was returned to Earth for analysis. The surface exploration was concluded in 2½ hours. With the success of Apollo 11, the national objective to land men on the Moon and return them safely to Earth had been accomplished.

Saturn Apollo Program

NASA Image and Video Library

1969-07-09

In preparation of the nation’s first lunar landing mission, Apollo 11, crew members underwent training to practice activities they would be performing during the mission. In this photograph Neil Armstrong approaches the helicopter he flew to practice landing the Lunar Module (LM) on the Moon. The Apollo 11 mission launched from the Kennedy Space Center (KSC) in Florida via the Marshall Space Flight Center (MSFC) developed Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. Aboard the space craft were astronauts Neil A. Armstrong, commander; Michael Collins, Command Module (CM) pilot; and Edwin E. (Buzz) Aldrin Jr., Lunar Module (LM) pilot. The CM, “Columbia”, piloted by Collins, remained in a parking orbit around the Moon while the LM, “Eagle’’, carrying astronauts Armstrong and Aldrin, landed on the Moon. On July 20, 1969, Armstrong was the first human to ever stand on the lunar surface, followed by Aldrin. During 2½ hours of surface exploration, the crew collected 47 pounds of lunar surface material for analysis back on Earth. With the success of Apollo 11, the national objective to land men on the Moon and return them safely to Earth had been accomplished

Partial loss of the DNA repair scaffolding protein, Xrcc1, results in increased brain damage and reduced recovery from ischemic stroke in mice

PubMed Central

Ghosh, Somnath; Canugovi, Chandrika; Yoon, Jeong Seon; Wilson, David M.; Croteau, Deborah L.; Mattson, Mark P.; Bohr, Vilhelm A.

2017-01-01

Oxidative DNA damage is mainly repaired by base excision repair (BER). Previously, our lab showed that mice lacking the BER glycosylases Ogg1 or Neil1 recover more poorly from focal ischemic stroke than wild-type mice. Here, a mouse model was used to investigate whether loss of one of the two alleles of Xrcc1, which encodes a non-enzymatic scaffold protein required for BER, alters recovery from stroke. Ischemia and reperfusion caused higher brain damage and lower functional recovery in Xrcc1+/− mice than in wild-type mice. Additionally, a greater percentage of Xrcc1+/− mice died as a result of the stroke. Brain samples from human individuals who died of stroke and individuals who died of non-neurological causes were assayed for various steps of BER. Significant losses of thymine glycol incision, abasic endonuclease incision and single nucleotide incorporation activities were identified, as well as lower expression of XRCC1 and NEIL1 proteins in stroke brains compared to controls. Together, these results suggest that impaired BER is a risk factor in ischemic brain injury and contributes to its recovery. PMID:25971543

Official Portrait of Astronaut Neil Armstrong

NASA Technical Reports Server (NTRS)

1969-01-01

Neil Armstrong, donned in his space suit, poses for his official Apollo 11 portrait. Armstrong began his flight career as a naval aviator. He flew 78 combat missions during the Korean War. Armstrong joined the NASA predecessor, NACA (National Advisory Committee for Aeronautics), as a research pilot at the Lewis Laboratory in Cleveland and later transferred to the NACA High Speed Flight Station at Edwards AFB, California. He was a project pilot on many pioneering high speed aircraft, including the 4,000 mph X-15. He has flown over 200 different models of aircraft, including jets, rockets, helicopters, and gliders. In 1962, Armstrong was transferred to astronaut status. He served as command pilot for the Gemini 8 mission, launched March 16, 1966, and performed the first successful docking of two vehicles in space. In 1969, Armstrong was commander of Apollo 11, the first manned lunar landing mission, and gained the distinction of being the first man to land a craft on the Moon and the first man to step on its surface. Armstrong subsequently held the position of Deputy Associate Administrator for Aeronautics, NASA Headquarters Office of Advanced Research and Technology, from 1970 to 1971. He resigned from NASA in 1971.

Saturn Apollo Program

NASA Image and Video Library

1969-07-27

The Apollo 11 mission, the first manned lunar mission, launched from the Kennedy Space Center, Florida via the Marshall Space Flight Center (MSFC) developed Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. Aboard the space craft were astronauts Neil A. Armstrong, commander; Michael Collins, Command Module (CM) pilot; and Edwin E. Aldrin Jr., Lunar Module (LM) pilot. The CM, piloted by Michael Collins remained in a parking orbit around the Moon while the LM, named “Eagle’’, carrying astronauts Neil Armstrong and Edwin Aldrin, landed on the Moon. During 2½ hours of surface exploration, the crew collected 47 pounds of lunar surface material for analysis back on Earth. The recovery operation took place in the Pacific Ocean where Navy para-rescue men recovered the capsule housing the 3-man Apollo 11 crew. The crew was airlifted to safety aboard the U.S.S. Hornet, where they were quartered in a Mobile Quarantine Facility (MQF) which served as their home until they reached the NASA Manned Spacecraft Center (MSC) Lunar Receiving Laboratory in Houston, Texas. In this close up of the MQF, commander Armstrong can be seen through the facility window after its arrival at the MSC.

7 CFR 351.2 - Location of inspectors.

Code of Federal Regulations, 2011 CFR

2011-01-01

..., Hoboken, N.J., Honolulu, Hawaii, Houston, Tex., Jacksonville, Fla., Jamaica, L.I., N.Y., Key West, Fla..., Calif., Savannah, Ga., Seattle, Wash., Tampa, Fla., Toledo, Ohio, Washington, DC, West Palm Beach, Fla...

7 CFR 351.2 - Location of inspectors.

Code of Federal Regulations, 2013 CFR

2013-01-01

..., Hoboken, N.J., Honolulu, Hawaii, Houston, Tex., Jacksonville, Fla., Jamaica, L.I., N.Y., Key West, Fla..., Calif., Savannah, Ga., Seattle, Wash., Tampa, Fla., Toledo, Ohio, Washington, DC, West Palm Beach, Fla...

7 CFR 351.2 - Location of inspectors.

Code of Federal Regulations, 2014 CFR

2014-01-01

..., Hoboken, N.J., Honolulu, Hawaii, Houston, Tex., Jacksonville, Fla., Jamaica, L.I., N.Y., Key West, Fla..., Calif., Savannah, Ga., Seattle, Wash., Tampa, Fla., Toledo, Ohio, Washington, DC, West Palm Beach, Fla...

7 CFR 351.2 - Location of inspectors.

Code of Federal Regulations, 2012 CFR

2012-01-01

..., Hoboken, N.J., Honolulu, Hawaii, Houston, Tex., Jacksonville, Fla., Jamaica, L.I., N.Y., Key West, Fla..., Calif., Savannah, Ga., Seattle, Wash., Tampa, Fla., Toledo, Ohio, Washington, DC, West Palm Beach, Fla...

33 CFR 334.590 - Atlantic Ocean off Cape Canaveral, Fla.; Air Force missile testing area, Patrick Air Force Base...

Code of Federal Regulations, 2010 CFR

2010-07-01

..., Fla.; Air Force missile testing area, Patrick Air Force Base, Fla. 334.590 Section 334.590 Navigation... RESTRICTED AREA REGULATIONS § 334.590 Atlantic Ocean off Cape Canaveral, Fla.; Air Force missile testing area, Patrick Air Force Base, Fla. (a) The danger zone. An area in the Atlantic Ocean immediately offshore from...

Flagellin diversity in Clostridium botulinum groups I and II: a new strategy for strain identification.

PubMed

Paul, Catherine J; Twine, Susan M; Tam, Kevin J; Mullen, James A; Kelly, John F; Austin, John W; Logan, Susan M

2007-05-01

Strains of Clostridium botulinum are traditionally identified by botulinum neurotoxin type; however, identification of an additional target for typing would improve differentiation. Isolation of flagellar filaments and analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) showed that C. botulinum produced multiple flagellin proteins. Nano-liquid chromatography-tandem mass spectrometry (nLC-MS/MS) analysis of in-gel tryptic digests identified peptides in all flagellin bands that matched two homologous tandem flagellin genes identified in the C. botulinum Hall A genome. Designated flaA1 and flaA2, these open reading frames encode the major structural flagellins of C. botulinum. Colony PCR and sequencing of flaA1/A2 variable regions classified 80 environmental and clinical strains into group I or group II and clustered isolates into 12 flagellar types. Flagellar type was distinct from neurotoxin type, and epidemiologically related isolates clustered together. Sequencing a larger PCR product, obtained during amplification of flaA1/A2 from type E strain Bennett identified a second flagellin gene, flaB. LC-MS analysis confirmed that flaB encoded a large type E-specific flagellin protein, and the predicted molecular mass for FlaB matched that observed by SDS-PAGE. In contrast, the molecular mass of FlaA was 2 to 12 kDa larger than the mass predicted by the flaA1/A2 sequence of a given strain, suggesting that FlaA is posttranslationally modified. While identification of FlaB, and the observation by SDS-PAGE of different masses of the FlaA proteins, showed the flagellin proteins of C. botulinum to be diverse, the presence of the flaA1/A2 gene in all strains examined facilitates single locus sequence typing of C. botulinum using the flagellin variable region.

Male Gender Role Conflict, Depression, and Anxiety: Clarification and Generalizability to Women

ERIC Educational Resources Information Center

Zamarripa, Manuel X.; Wampold, Bruce E.; Gregory, Erik

2003-01-01

The purpose of this study was (a) to determine whether the relationship between male gender role conflict variables and mental health generalizes to women and (b) to investigate other aspects of social gender roles and mental health. An adaptation of the Gender Role Conflict Scale (I. M. O'Neil, B. J. Helms, R. K. Gable. L. David, & L. S.…

ASTRONAUT GROUP - PORTRAIT

NASA Image and Video Library

1962-10-01

S62-06759 (1962) --- This is the second group of pilot astronauts chosen by the National Aeronautics and Space Administration (NASA). These astronaut pilots are (kneeling left to right) Charles Conrad, Jr., Frank Borman, Neil A. Armstrong, and John W. Young; (standing in the back row - left to right) Elliot M. See, Jr., James A. McDivitt, James A. Lovell, Jr., Edward H. White II, and Thomas P. Stafford.

Geospace Plasma Dynamics Laboratory Annual Task Report (FY11)

DTIC Science & Technology

2012-03-01

Site Contractors: Nagendra Singh, Ph.D., Physicist , 0.5 MY Neil Grossbard, M.S., Mathematician , 0.7 MY Visitors: Publications: Articles in...PhD Project Manager Division Chief, RVB This report is published in the interest of scientific and technical...Annual Task Report (FY11) 5c. PROGRAM ELEMENT NUMBER 61102F 6. AUTHOR(S) 5d. PROJECT NUMBER 2311 Daniel Ober 5e. TASK NUMBER

Military Retirement and Wealth Forecasting During DOD Manpower Drawdown

DTIC Science & Technology

2013-09-01

DRAWDOWN 5. FUNDING NUMBERS 6. AUTHOR( S ) Steven D. Mays 7. PERFORMING ORGANIZATION NAME( S ) AND ADDRESS(ES) Naval Postgraduate School Monterey, CA...93943-5000 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING /MONITORING AGENCY NAME( S ) AND ADDRESS(ES) N/A 10. SPONSORING/MONITORING...through retirement (McNeil, 2013). The imposed drawdown parameters lessen that likelihood. B. RETIREMENT BEHAVIORS 1. Age Maestas (2009) and

KSC-97pc582

NASA Image and Video Library

1997-04-04

Apollo l1 Commander Neil A. Armstrong and his wife, Carol, were among the many special NASA STS-83 launch guests who witnessed the liftoff of the Space Shuttle Columbia April 4 at the Banana Creek VIP Viewing Site at KSC. Columbia took off from Launch Pad 39A at 2:20:32 p.m. EST to begin the 16-day Microgravity Science Laboratory-1 (MSL-1) mission

Automated System for Holographic Lightfield 3D Display Metrology (HL3DM)

DTIC Science & Technology

2015-04-01

see that: Equation 7 - X = L* TAN (Ɵ)  Ɵ = ATAN(X/L) Equation 8 - L^2 + (X + W/2)^2 = P^2  P = sqrt( L^2 + (X + W/2)^2 ) Equation 9 - P...Physiol. Opt 2011, 31, 111–122. (2011, The College of Optometrists) 12. Nicolas S. Holliman, Neil A. Dodgson, Gregg E. Favalora, and Lachlan Pockett

Chemoprevention of Ovarian Cancer

DTIC Science & Technology

2006-10-01

negotiated with Ortho-McNeil to formulate had expired. We then had to work with the local drug representative to find adequate amounts of drug for the...difficulty in accessing the ovaries in their intraperitoneal location, and, unlike the uterine cervix or endometrium, the necessity for an anesthetic ...a palatable treat by a veterinary phar- macist. Doses of 4HPR (Fenretide: RW Johnson Pharmaceutical Research Institute, San Diego, Calif.) and OCP

Understandings and Tendencies of Edutainment in Turkey: An Evaluation Based on Neil Postman's Criticism on Education, Entertainment and Technology

ERIC Educational Resources Information Center

Yaylaci, Filiz Goktuna; Yaylaci, Ali Faruk

2016-01-01

There have been a wide range of studies on the interplay between education and technology. Furthermore, there are many other studies aimed at analyzing the scholarly output on this subject with a holistic approach. However the studies are mostly focused on the facilitator role of technology. Although the idea that educational processes have become…

Canadian Association for the Study of Adult Education. Proceedings of the Annual Conferences (6th, Hamilton, Ontario, Canada, May 29-31, 1987).

ERIC Educational Resources Information Center

Gillen, Marie A., Ed.; Burkholder, Avon, Ed.

These proceedings contain 14 papers and notes from 2 symposia in English and 2 papers in French. Abstracts appear at the beginning of the volume. The following papers are included: "Symposium Notes: What Is the Future of Adult Education in Canada?" (Bernard, MacNeil, Selman); "John Dewey Dialogues with an Adult Educator in…

Defense.gov - Special Report - 2009 Employer Support Freedom Awards

Science.gov Websites

updated and may no longer be applicable as a result of changes in law, regulation and/or administration Jackson Parish (La.) Sheriff’s Office WASHINGTON, Sept. 14, 2009 – Law enforcement and military service . Story Marks, O’Neil, O’Brien and Courtney Law Firm WASHINGTON, Aug. 28, 2009 – The past five years

Werner von Braun relaxes after successful Apollo 11 Saturn V launch

NASA Technical Reports Server (NTRS)

1969-01-01

Dr. Wernher von Braun, director of the Marshall Space Flight Center, Huntsville, Alabama, relaxes after the successful launch of Apollo 11 astronauts Neil A. Armstrong, Michael Collins and Edwin Aldrin Jr. today. Their historic lunar landing mission began at 9:32 a.m. EDT, July 16, 1969, when an Apollo/Saturn V space vehicle lifted off from the spaceport's Launch Complex 39A.

The Normals to a Parabola and the Real Roots of a Cubic

ERIC Educational Resources Information Center

Bains, Majinder S.; Thoo, J. B.

2007-01-01

The geometric problem of finding the number of normals to the parabola y = x[squared] through a given point is equivalent to the algebraic problem of finding the number of distinct real roots of a cubic equation. Apollonius solved the former problem, and Cardano gave a solution to the latter. The two problems are bridged by Neil's (semi-cubical)…

Reliability and Validity of the Computerized Revised Token Test: Comparison of Reading and Listening Versions in Persons with and without Aphasia

ERIC Educational Resources Information Center

McNeil, Malcolm R.; Pratt, Sheila R.; Szuminsky, Neil; Sung, Jee Eun; Fossett, Tepanta R. D.; Fassbinder, Wiltrud; Lim, Kyoung Yuel

2015-01-01

Purpose: This study assessed the reliability and validity of intermodality associations and differences in persons with aphasia (PWA) and healthy controls (HC) on a computerized listening and 3 reading versions of the Revised Token Test (RTT; McNeil & Prescott, 1978). Method: Thirty PWA and 30 HC completed the test versions, including a…

Satellite SAR Exploitation and Imaging and Measurement of Oceanic Phenomena

DTIC Science & Technology

2014-09-30

252-4407, email: hgraber@rsmas.miami.edu William M. Drennan Rosenstiel School of Marine and Atmospheric Science University of Miami 4600...School of Marine and Atmospheric Science University of Miami 4600 Rickenbacker Causeway Miami, Florida 33149-1098 phone: (305) 421-4645, fax: (305...421-4701, email: rromeiser@miami.edu Neil J. Williams Rosenstiel School of Marine and Atmospheric Science University of Miami 4600

Toward Determining the Comprehensibility of Machine Translations

DTIC Science & Technology

2012-01-01

responses to a stimulus (Macmillan and Creelman , 1991). It has been applied in areas such as lie detection (truth/lie), inspection (ac- ceptable...1-1/(2N) (Macmil- lan and Creelman , 1991). Negative values, which usually indicate response confusion, were eliminated. The results of...Macmillan, Neil and C. Douglas Creelman . (1991). Detection theory: A User’s guide. Cambridge Univer- sity Press, pp. 10 &125. Marchant

Merida Initiative: Insight Into U.S. Mexico Relations

DTIC Science & Technology

2016-09-01

investigations against money laundering , improving interdiction capability, and by supporting effective command and control centers across Mexico.”147 The...the “Marijuana Boom,” the Colombian government “helped to institutionalize money laundering , enabling contraband importers and exporters to carry on...United States must also address money laundering . According to O’Neil, “Federal investigators believe that over the course of a few years, Mexico’s

LUNAR SAMPLES - APOLLO XI - MSC

NASA Image and Video Library

1969-08-03

S69-40740 (July 1969) --- Dr. Ross Taylor (seated), Australian National University, and John Allen, Brown and Root-Northrop technician, review preliminary data from the optical emission spectrograph in the Spectrographic Laboratory of the Physical-Chemical Test Laboratory. Tests were being conducted on lunar surface material collected by astronauts Neil A. Armstrong and Edwin E. Aldrin Jr. during their lunar surface extravehicular activity on July 20, 1969.

A Role for the Fifth G-Track in G-Quadruplex Forming Oncogene Promoter Sequences during Oxidative Stress: Do These “Spare Tires” Have an Evolved Function?

PubMed Central

2015-01-01

Uncontrolled inflammation or oxidative stress generates electron-deficient species that oxidize the genome increasing its instability in cancer. The G-quadruplex (G4) sequences regulating the c-MYC, KRAS, VEGF, BCL-2, HIF-1α, and RET oncogenes, as examples, are targets for oxidation at loop and 5′-core guanines (G) as showcased in this study by CO3•– oxidation of the VEGF G4. Products observed include 8-oxo-7,8-dihydroguanine (OG), spiroiminodihydantoin (Sp), and 5-guanidinohydantoin (Gh). Our previous studies found that OG and Gh, when present in the four G-tracks of the solved structure for VEGF and c-MYC, were not substrates for the base excision repair (BER) DNA glycosylases in biologically relevant KCl solutions. We now hypothesize that a fifth G-track found a few nucleotides distant from the G4 tracks involved in folding can act as a “spare tire,” facilitating extrusion of a damaged G-run into a large loop that then becomes a substrate for BER. Thermodynamic, spectroscopic, and DMS footprinting studies verified the fifth domain replacing a damaged G-track with OG or Gh at a loop or core position in the VEGF G4. These new “spare tire”-containing strands with Gh in loops are now found to be substrates for initiation of BER with the NEIL1, NEIL2, and NEIL3 DNA glycosylases. The results support a hypothesis in which regulatory G4s carry a “spare-tire” fifth G-track for aiding in the repair process when these sequences are damaged by radical oxygen species, a feature observed in a large number of these sequences. Furthermore, formation and repair of oxidized bases in promoter regions may constitute an additional example of epigenetic modification, in this case of guanine bases, to regulate gene expression in which the G4 sequences act as sensors of oxidative stress. PMID:26405692

Construction of recombinant Mip-FlaA dominant epitope vaccine against Legionella pneumophila and evaluation of the immunogenicity and protective immunity.

PubMed

He, Jinlei; Zhang, Junrong; He, Yanxia; Huang, Fan; Li, Jiao; Chen, Qiwei; Chen, Dali; Chen, Jianping

2016-02-01

Legionnaires' disease, a kind of systemic disease with pneumonia as the main manifestation, is caused by Legionella pneumophila (L. pneumophila). In order to prevent the disease, we optimized Mip and FlaA, the virulence factors of L. pneumophila, to design recombinant Mip-FlaA dominant epitope vaccine against the pathogen. Firstly, the coding sequences of mip and flaA were optimized by DNAStar software and Expasy protein analysis system, and then, the tertiary structure and function of recombinant Mip-FlaA were predicted by PHYRE2 Protein Fold Recognition Server. After that, the optimized mip, flaA and mip-flaA were cloned, expressed and purified, and the proteins were used as dominant epitope vaccines to immunize BABL/c mice. Moreover, the IgG titers, histological changes in lung and the level of TNF-α, IFN-γ, IL-6 and IL-1β were detected to reflect the immunogenicity and protective immunity of the vaccines. The results of SDS-PAGE and Western blot proved the recombinant Mip-FlaA was successfully expressed. ELISA results of IgG titers and these cytokines showed Mip-FlaA group was capable to induce the strongest immune response, compared to PBS, Mip and FlaA groups. In addition, histopathology analysis demonstrated the mice immunized with Mip-FlaA showed better immune protection. Therefore, the work indicated that the above-described biological tools were useful in optimization of epitope vaccine. Antigenic characterization and immune protection of recombinant Mip-FlaA would be of great value in understanding the immunopathogenesis of the disease and in developing possible vaccine against the pathogen.

Flagellin Diversity in Clostridium botulinum Groups I and II: a New Strategy for Strain Identification▿

PubMed Central

Paul, Catherine J.; Twine, Susan M.; Tam, Kevin J.; Mullen, James A.; Kelly, John F.; Austin, John W.; Logan, Susan M.

2007-01-01

Strains of Clostridium botulinum are traditionally identified by botulinum neurotoxin type; however, identification of an additional target for typing would improve differentiation. Isolation of flagellar filaments and analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) showed that C. botulinum produced multiple flagellin proteins. Nano-liquid chromatography-tandem mass spectrometry (nLC-MS/MS) analysis of in-gel tryptic digests identified peptides in all flagellin bands that matched two homologous tandem flagellin genes identified in the C. botulinum Hall A genome. Designated flaA1 and flaA2, these open reading frames encode the major structural flagellins of C. botulinum. Colony PCR and sequencing of flaA1/A2 variable regions classified 80 environmental and clinical strains into group I or group II and clustered isolates into 12 flagellar types. Flagellar type was distinct from neurotoxin type, and epidemiologically related isolates clustered together. Sequencing a larger PCR product, obtained during amplification of flaA1/A2 from type E strain Bennett identified a second flagellin gene, flaB. LC-MS analysis confirmed that flaB encoded a large type E-specific flagellin protein, and the predicted molecular mass for FlaB matched that observed by SDS-PAGE. In contrast, the molecular mass of FlaA was 2 to 12 kDa larger than the mass predicted by the flaA1/A2 sequence of a given strain, suggesting that FlaA is posttranslationally modified. While identification of FlaB, and the observation by SDS-PAGE of different masses of the FlaA proteins, showed the flagellin proteins of C. botulinum to be diverse, the presence of the flaA1/A2 gene in all strains examined facilitates single locus sequence typing of C. botulinum using the flagellin variable region. PMID:17351097

POTENTIALLY PATHOGENIC FREE-LIVING AMOEBAE IN SOME FLOOD-AFFECTED AREAS DURING 2011 CHIANG MAI FLOOD

PubMed Central

Wannasan, Anchalee; Uparanukraw, Pichart; Songsangchun, Apichart; Morakote, Nimit

2013-01-01

SUMMARY The survey was carried out to investigate the presence of potentially pathogenic free-living amoebae (FLA) during flood in Chiang Mai, Thailand in 2011. From different crisis flood areas, seven water samples were collected and tested for the presence of amoebae using culture and molecular methods. By monoxenic culture, FLA were detected from all samples at 37 °C incubation. The FLA growing at 37 °C were morphologically identified as Acanthamoeba spp., Naegleria spp. and some unidentified amoebae. Only three samples (42.8%), defined as thermotolerant FLA, continued to grow at 42 °C. By molecular methods, two non-thermotolerant FlA were shown to have 99% identity to Acanthamoeba sp. and 98% identity to Hartmannella vermiformis while the two thermotolerant FLA were identified as Echinamoeba exundans (100% identity) and Hartmannella sp. (99% identity). This first report of the occurrence of FLA in water during the flood disaster will provide information to the public to be aware of potentially pathogenic FLA. PMID:24213194

Potentially pathogenic free-living amoebae in some flood-affected areas during 2011 Chiang Mai flood.

PubMed

Wannasan, Anchalee; Uparanukraw, Pichart; Songsangchun, Apichart; Morakote, Nimit

2013-01-01

The survey was carried out to investigate the presence of potentially pathogenic free-living amoebae (FLA) during flood in Chiang Mai, Thailand in 2011. From different crisis flood areas, seven water samples were collected and tested for the presence of amoebae using culture and molecular methods. By monoxenic culture, FLA were detected from all samples at 37 °C incubation. The FLA growing at 37 °C were morphologically identified as Acanthamoeba spp., Naegleria spp. and some unidentified amoebae. Only three samples (42.8%), defined as thermotolerant FLA, continued to grow at 42 °C. By molecular methods, two non-thermotolerant FlA were shown to have 99% identity to Acanthamoeba sp. and 98% identity to Hartmannella vermiformis while the two thermotolerant FLA were identified as Echinamoeba exundans (100% identity) and Hartmannella sp. (99% identity). This first report of the occurrence of FLA in water during the flood disaster will provide information to the public to be aware of potentially pathogenic FLA.

Acanthamoeba and other free-living amoebae in bat guano, an extreme habitat.

PubMed

Mulec, Janez; Dietersdorfer, Elisabeth; Üstüntürk-Onan, Miray; Walochnik, Julia

2016-04-01

Several representatives of the so-called free-living amoebae (FLA) are of medical relevance, not only as facultative pathogens but also as vehicles for pathogenic bacteria. Some FLA can survive and even grow under extreme environmental conditions. Bat guano is an exceptional habitat, the conditions becoming gradually more extreme with aging. In the current study, samples of bat guano of different ages from five caves in Slovenia were screened for the presence of FLA. FLA were isolated from almost all guano samples, including guano with a pH of 3.5. Only the two samples that had been drawn from >20-year-old guano were negative for FLA. Generally, FLA diversity correlated to high concentrations of cultivable bacteria (∼10(8) CFU/g) and fungi (∼10(5) CFU/g). Interestingly, the absence of FLA in seasoned guanos was mirrored by the presence of dictyostelid slime moulds. The isolated amoebae were identified as belonging to the genera Acanthamoeba, Copromyxa, Naegleria, Sappinia, Tetramitus, Thecamoeba, Vahlkampfia, Vannella and Vermamoeba. To the best of our knowledge, this is the first study on the diversity of FLA in guano.

Protection against Legionnaire's Disease: Recombinant Flagellin A of Legionella pneumophila Can Induce Protective Immunity against Bacteremia in a BALB/c Murine Model.

PubMed

Mohabati Mobarez, Ashraf; Ahmadrajabi, Roya; Khoramabadi, Nima; Salmanian, Ali-Hatef

2017-01-01

To investigate the immunoprotective effects of the recombinant type A flagellin (FLA), the flaA gene of Legionella pneumophila serogroup 1 strain Paris was cloned into pET28a(+). Recombinant FLA (rFLA) was overexpressed in E. coli BL21 (DE3) and purified by Ni2+ exchange chromatography. Female BALB/c aged 6-8 weeks were immunized with 20 μg of rFLA. Nonimmunized mice along with mice inoculated with a sublethal dose of live L. pneumophila intravenously were considered as negative and positive controls, respectively. A significant serum antibody response was observed in female BALB/c mice immunized with rFLA. Production of IFN-γ and IL-12, and TNF-α in the serum and the splenocyte cultures, and antigen-specific splenocyte proliferation suggested a strong innate and adaptive cell-mediated immunity response in rFLA-immunized mice. Intravenous lethal challenge with L. pneumophila serogroup 1 (strain Paris) showed that 60% of mice immunized with rFLA survived in a 10-day follow-up survey. These results show that rFLA from L. pneumophila can elicit strong innate and adaptive immune responses and suggest the possibility of a long-term immunity against lethal challenge with L. pneumophila. © 2017 S. Karger AG, Basel.

Apollo XI Crewmen - Dining - Crew Reception Area - Lunar Receiving Lab (LRL) - MSC

NASA Image and Video Library

1969-07-30

S69-40306 (30 July 1969) --- The crewmen of the historic Apollo 11 lunar landing mission are seen dining in the Crew Reception Area of the Lunar Receiving Laboratory, Building 37, Manned Spacecraft Center. Left to right, are astronauts Edwin E. Aldrin Jr., Michael Collins, and Neil A. Armstrong. They are continuing their postflight debriefings. The astronauts will be released from quarantine on Aug. 11, 1969.

Is There Future Utility in Nuclear Weapons Nuclear Weapons Save Lives

DTIC Science & Technology

2014-02-13

operate with relative impunity short of large-scale conflict. Some point to a nuclear India and Pakistan as an example of instability concern. In...1997, South Asia observer Neil Joeck argued that “ India and Pakistan’s nuclear capabilities have not created strategic stability (and) do not reduce...elimination of illiteracy , provision of sustainable energy, debt relief for developing countries, clearance of landmines and more has been estimated

Detection And Classification Of Web Robots With Honeypots

DTIC Science & Technology

2016-03-01

CLASSIFICATION OF WEB ROBOTS WITH HONEYPOTS by Sean F. McKenna March 2016 Thesis Advisor: Neil Rowe Second Reader: Justin P. Rohrer THIS...Master’s thesis 4. TITLE AND SUBTITLE DETECTION AND CLASSIFICATION OF WEB ROBOTS WITH HONEYPOTS 5. FUNDING NUMBERS 6. AUTHOR(S) Sean F. McKenna 7...DISTRIBUTION CODE 13. ABSTRACT (maximum 200 words) Web robots are automated programs that systematically browse the Web , collecting information. Although

CTC Sentinel. Volume 4, Issue 8

DTIC Science & Technology

2011-08-01

direct threat to national security and public safety because of their sup- port for terrorism. As a result, they are being monitored by German law...proper) Muslim way of life. Therefore, they often quit habits such as drinking alcohol and eating pork . Many converts have mentioned difficult times...Neil (Ibrahim) Golightly, a 34-year-old convert from Glasgow, was killed while trying to bring food and supplies to besieged Sarajevo in August 1995

ARC-2008-ACD08-0186-005

NASA Image and Video Library

2008-07-30

NASA Ames Robotics Academy Interns at the Lunar Science Institute (LSI) building 17 Interns: David Black, Michael Zwach, Guy Chriqui, Mark Mordarski Jr., Katy Levinson, Daniela Buchman, Scott Strutner, Patrick Crownover, Neil Bhateja, Michael Buchman, John Mueller, Michelle Grau, Ben Silver, Jacques Dolan, Alex Golec Windell Jones, Colin Wilson, Joe DeBlasio, Nick Hayes, Jordan Olive, William Shaw, Ames Education Dept., Mark Leon, Ames Robotics, Josh Weiner, jack Biesiadecki, Andrew Pilloud

Sustainable Range Management of RDX and TNT by Phytoremediation with Engineered Plants

DTIC Science & Technology

2016-04-01

FINAL REPORT Sustainable Range Management of RDX and TNT by Phytoremediation with Engineered Plants SERDP Project ER-1498 APRIL 2016...specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise, does not necessarily constitute or imply its...by Phyoremediation with Engineered Plants 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER ER-1498 Neil C

Keeping Kids Safe: Exploring Public/Private Partnerships To Prevent Abuse and Strengthen Families. Hearing before the Select Committee on Children, Youth, and Families, House of Representatives, One Hundred Second Congress, Second Session.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. House Select Committee on Children, Youth, and Families.

The text of a hearing on successful efforts to prevent child abuse and strengthen families is presented in this document. After an opening statement by chairwoman Representative Patricia Schroeder, statements are presented by Representatives Robert E. "Bud" Cramer, Jr., Neil Abercrombie, Blackwell, Gerry Sikorski, Matthew Martinez, Frank…

30. Photocopy of a photograph (original print in the collection ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

30. Photocopy of a photograph (original print in the collection of the New Hampshire Water Resources Board, Concord, New Hampshire) 1934, photographer unknown 3 1/4 X 4 5/8 inch negative INTAKE TO THE POWER CANAL AT DAM No. 5. IDE'S 'ROUND BUILDING' IN THE FREEMAN AND O'NEIL COMPLEX IS VISIBLE ON THE LEFT. - Claremont Village Industrial District, Between B, Claremont, Sullivan County, NH