Sample records for flash thick-target experiment

  1. Flash characteristics of plasma induced by hypervelocity impact

    NASA Astrophysics Data System (ADS)

    Zhang, Kai; Long, Renrong; Zhang, Qingming; Xue, Yijiang; Ju, Yuanyuan

    2016-08-01

    Using a two-stage light gas gun, a series of hypervelocity impact experiments was conducted in which 6.4-mm-diameter spherical 2024-aluminum projectiles impact 23-mm-thick targets made of the same material at velocities of 5.0, 5.6, and 6.3 km/s. Both an optical pyrometer composed of six photomultiplier tubes and a spectrograph were used to measure the flash of the plasma during hypervelocity impact. Experimental results show that, at a projectile velocity of 6.3 km/s, the strong flash lasted about 10 μs and reached a temperature of 4300 K. Based on the known emission lines of AL I, spectral methods can provide the plasma electron temperature. An electron-temperature comparison between experiment and theoretical calculation indicates that single ionization and secondary ionization are the two main ionizing modes at velocities 5.0-6.3 km/s.

  2. Flash characteristics of plasma induced by hypervelocity impact

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhang, Kai; Beijing Automotive Technology Center, Beijing 100021; Long, Renrong, E-mail: longrenrong@bit.edu.cn, E-mail: qmzhang@bit.edu.cn

    2016-08-15

    Using a two-stage light gas gun, a series of hypervelocity impact experiments was conducted in which 6.4-mm-diameter spherical 2024-aluminum projectiles impact 23-mm-thick targets made of the same material at velocities of 5.0, 5.6, and 6.3 km/s. Both an optical pyrometer composed of six photomultiplier tubes and a spectrograph were used to measure the flash of the plasma during hypervelocity impact. Experimental results show that, at a projectile velocity of 6.3 km/s, the strong flash lasted about 10 μs and reached a temperature of 4300 K. Based on the known emission lines of AL I, spectral methods can provide the plasma electron temperature. An electron-temperaturemore » comparison between experiment and theoretical calculation indicates that single ionization and secondary ionization are the two main ionizing modes at velocities 5.0–6.3 km/s.« less

  3. Egocentric and Allocentric Localization During Induced Motion

    PubMed Central

    Post, Robert B.; Welch, Robert B.; Whitney, David

    2009-01-01

    This research examined motor measures of the apparent egocentric location and perceptual measures of the apparent allocentric location of a target that was being seen to undergo induced motion (IM). In Experiments 1 and 3, subjects fixated a stationary dot (IM target) while a rectangular surround stimulus (inducing stimulus) oscillated horizontally. The inducing stimulus motion caused the IM target to appear to move in the opposite direction. In Experiment 1, two dots (flashed targets) were flashed above and below the IM target when the surround had reached its leftmost or rightmost displacement from the subject’s midline. Subjects pointed open loop at either the apparent egocentric location of the IM target or at the bottom of the two flashed targets. On separate trials, subjects made judgments of the Vernier alignment of the IM target with the flashed targets at the endpoints of the surround’s oscillation. The pointing responses were displaced in the direction of the previously seen IM for the IM target and to a lesser degree for the bottom flashed target. However, the allocentric Vernier judgments demonstrated no perceptual displacement of the IM target relative to the flashed targets. Thus, IM results in a dissociation of egocentric location measures from allocentric location measures. In Experiment 2, pointing and Vernier measures were obtained with stationary horizontally displaced surrounds and there was no dissociation of egocentric location measures from allocentric location measures. These results indicate that the Roelofs effect did not produce the pattern of results in Experiment 1. In Experiment 3, pointing and Vernier measures were obtained when the surround was at the midpoint of an oscillation. In this case, egocentric pointing responses were displaced in the direction of surround motion (opposite IM) for the IM target and to a greater degree for the bottom flashed target. However, there was no apparent displacement of the IM target relative to the flashed targets in the allocentric Vernier judgments. Therefore, in Experiment 3 egocentric location measures were again dissociated from allocentric location measures. The results of this experiment also demonstrate that IM does not generate an allocentric displacement illusion analogous to the “flash-lag” effect. PMID:18751688

  4. Flash trajectory imaging of target 3D motion

    NASA Astrophysics Data System (ADS)

    Wang, Xinwei; Zhou, Yan; Fan, Songtao; He, Jun; Liu, Yuliang

    2011-03-01

    We present a flash trajectory imaging technique which can directly obtain target trajectory and realize non-contact measurement of motion parameters by range-gated imaging and time delay integration. Range-gated imaging gives the range of targets and realizes silhouette detection which can directly extract targets from complex background and decrease the complexity of moving target image processing. Time delay integration increases information of one single frame of image so that one can directly gain the moving trajectory. In this paper, we have studied the algorithm about flash trajectory imaging and performed initial experiments which successfully obtained the trajectory of a falling badminton. Our research demonstrates that flash trajectory imaging is an effective approach to imaging target trajectory and can give motion parameters of moving targets.

  5. Non-invasive online wavelength measurements at FLASH2 and present benchmark

    PubMed Central

    Braune, Markus; Buck, Jens; Kuhlmann, Marion; Grunewald, Sören; Düsterer, Stefan; Viefhaus, Jens; Tiedtke, Kai

    2018-01-01

    At FLASH2, the free-electron laser radiation wavelength is routinely measured by an online spectrometer based on photoionization of gas targets. Photoelectrons are detected with time-of-flight spectrometers and the wavelength is determined by means of well known binding energies of the target species. The wavelength measurement is non-invasive and transparent with respect to running user experiments due to the low gas pressure applied. Sophisticated controls for setting the OPIS operation parameters have been created and integrated into the distributed object-oriented control system at FLASH2. Raw and processed data can be stored on request in the FLASH data acquisition system for later correlation with data from user experiments or re-analysis. In this paper, the commissioning of the instrument at FLASH2 and the challenges of space charge effects on wavelength determination are reported. Furthermore, strategies for fast data reduction and online data processing are presented. PMID:29271744

  6. Compatibility of motion facilitates visuomotor synchronization.

    PubMed

    Hove, Michael J; Spivey, Michael J; Krumhansl, Carol L

    2010-12-01

    Prior research indicates that synchronized tapping performance is very poor with flashing visual stimuli compared with auditory stimuli. Three finger-tapping experiments compared flashing visual metronomes with visual metronomes containing a spatial component, either compatible, incompatible, or orthogonal to the tapping action. In Experiment 1, synchronization success rates increased dramatically for spatiotemporal sequences of both geometric and biological forms over flashing sequences. In Experiment 2, synchronization performance was best when target sequences and movements were directionally compatible (i.e., simultaneously down), followed by orthogonal stimuli, and was poorest for incompatible moving stimuli and flashing stimuli. In Experiment 3, synchronization performance was best with auditory sequences, followed by compatible moving stimuli, and was worst for flashing and fading stimuli. Results indicate that visuomotor synchronization improves dramatically with compatible spatial information. However, an auditory advantage in sensorimotor synchronization persists.

  7. Menopausal Hot Flashes and Carotid Intima Media Thickness Among Midlife Women.

    PubMed

    Thurston, Rebecca C; Chang, Yuefang; Barinas-Mitchell, Emma; Jennings, J Richard; Landsittel, Doug P; Santoro, Nanette; von Känel, Roland; Matthews, Karen A

    2016-12-01

    There has been a longstanding interest in the role of menopause and its correlates in the development of cardiovascular disease (CVD) in women. Menopausal hot flashes are experienced by most midlife women; emerging data link hot flashes to CVD risk indicators. We tested whether hot flashes, measured via state-of-the-art physiologic methods, were associated with greater subclinical atherosclerosis as assessed by carotid ultrasound. We considered the role of CVD risk factors and estradiol concentrations in these associations. A total of 295 nonsmoking women free of clinical CVD underwent ambulatory physiologic hot flash assessments; a blood draw; and carotid ultrasound measurement of intima media thickness and plaque. Associations between hot flashes and subclinical atherosclerosis were tested in regression models controlling for CVD risk factors and estradiol. More frequent physiologic hot flashes were associated with higher carotid intima media thickness (for each additional hot flash: β [SE]=0.004 [0.001]; P=0.0001; reported hot flash: β [SE]=0.008 [0.002]; P=0.002, multivariable) and plaque (eg, for each additional hot flash, odds ratio [95% confidence interval] plaque index ≥2=1.07 [1.003-1.14]; P=0.04, relative to no plaque, multivariable] among women reporting daily hot flashes; associations were not accounted for by CVD risk factors or by estradiol. Among women reporting hot flashes, hot flashes accounted for more variance in intima media thickness than most CVD risk factors. Among women reporting daily hot flashes, frequent hot flashes may provide information about a woman's vascular status beyond standard CVD risk factors and estradiol. Frequent hot flashes may mark a vulnerable vascular phenotype among midlife women. © 2016 American Heart Association, Inc.

  8. FLASH hydrodynamic simulations of experiments to explore the generation of cosmological magnetic fields

    NASA Astrophysics Data System (ADS)

    Scopatz, A.; Fatenejad, M.; Flocke, N.; Gregori, G.; Koenig, M.; Lamb, D. Q.; Lee, D.; Meinecke, J.; Ravasio, A.; Tzeferacos, P.; Weide, K.; Yurchak, R.

    2013-03-01

    We report the results of FLASH hydrodynamic simulations of the experiments conducted by the University of Oxford High Energy Density Laboratory Astrophysics group and its collaborators at the Laboratoire pour l'Utilisation de Lasers Intenses (LULI). In these experiments, a long-pulse laser illuminates a target in a chamber filled with Argon gas, producing shock waves that generate magnetic fields via the Biermann battery mechanism. The simulations show that the result of the laser illuminating the target is a series of complex hydrodynamic phenomena.

  9. Moving target detection in flash mode against stroboscopic mode by active range-gated laser imaging

    NASA Astrophysics Data System (ADS)

    Zhang, Xuanyu; Wang, Xinwei; Sun, Liang; Fan, Songtao; Lei, Pingshun; Zhou, Yan; Liu, Yuliang

    2018-01-01

    Moving target detection is important for the application of target tracking and remote surveillance in active range-gated laser imaging. This technique has two operation modes based on the difference of the number of pulses per frame: stroboscopic mode with the accumulation of multiple laser pulses per frame and flash mode with a single shot of laser pulse per frame. In this paper, we have established a range-gated laser imaging system. In the system, two types of lasers with different frequency were chosen for the two modes. Electric fan and horizontal sliding track were selected as the moving targets to compare the moving blurring between two modes. Consequently, the system working in flash mode shows more excellent performance in motion blurring against stroboscopic mode. Furthermore, based on experiments and theoretical analysis, we presented the higher signal-to-noise ratio of image acquired by stroboscopic mode than flash mode in indoor and underwater environment.

  10. Opposite ERP effects for conscious and unconscious semantic processing under continuous flash suppression.

    PubMed

    Yang, Yung-Hao; Zhou, Jifan; Li, Kuei-An; Hung, Tifan; Pegna, Alan J; Yeh, Su-Ling

    2017-09-01

    We examined whether semantic processing occurs without awareness using continuous flash suppression (CFS). In two priming tasks, participants were required to judge whether a target was a word or a non-word, and to report whether the masked prime was visible. Experiment 1 manipulated the lexical congruency between the prime-target pairs and Experiment 2 manipulated their semantic relatedness. Despite the absence of behavioral priming effects (Experiment 1), the ERP results revealed that an N4 component was sensitive to the prime-target lexical congruency (Experiment 1) and semantic relatedness (Experiment 2) when the prime was rendered invisible under CFS. However, these results were reversed with respect to those that emerged when the stimuli were perceived consciously. Our findings suggest that some form of lexical and semantic processing can occur during CFS-induced unawareness, but are associated with different electrophysiological outcomes. Copyright © 2017 Elsevier Inc. All rights reserved.

  11. Remote collection and analysis of witness reports on flash floods

    NASA Astrophysics Data System (ADS)

    Gourley, Jonathan; Erlingis, Jessica; Smith, Travis; Ortega, Kiel; Hong, Yang

    2010-05-01

    Typically, flash floods are studied ex post facto in response to a major impact event. A complement to field investigations is developing a detailed database of flash flood events, including minor events and null reports (i.e., where heavy rain occurred but there was no flash flooding), based on public survey questions conducted in near-real time. The Severe Hazards Analysis and Verification Experiment (SHAVE) has been in operation at the National Severe Storms Laboratory (NSSL) in Norman, OK, USA during the summers since 2006. The experiment employs undergraduate students to analyse real-time products from weather radars, target specific regions within the conterminous US, and poll public residences and businesses regarding the occurrence and severity of hail, wind, tornadoes, and now flash floods. In addition to providing a rich learning experience for students, SHAVE has been successful in creating high-resolution datasets of severe hazards used for algorithm and model verification. This talk describes the criteria used to initiate the flash flood survey, the specific questions asked and information entered to the database, and then provides an analysis of results for flash flood data collected during the summer of 2008. It is envisioned that specific details provided by the SHAVE flash flood observation database will complement databases collected by operational agencies and thus lead to better tools to predict the likelihood of flash floods and ultimately reduce their impacts on society.

  12. Targeting an efficient target-to-target interval for P300 speller brain–computer interfaces

    PubMed Central

    Sellers, Eric W.; Wang, Xingyu

    2013-01-01

    Longer target-to-target intervals (TTI) produce greater P300 event-related potential amplitude, which can increase brain–computer interface (BCI) classification accuracy and decrease the number of flashes needed for accurate character classification. However, longer TTIs requires more time for each trial, which will decrease the information transfer rate of BCI. In this paper, a P300 BCI using a 7 × 12 matrix explored new flash patterns (16-, 18- and 21-flash pattern) with different TTIs to assess the effects of TTI on P300 BCI performance. The new flash patterns were designed to minimize TTI, decrease repetition blindness, and examine the temporal relationship between each flash of a given stimulus by placing a minimum of one (16-flash pattern), two (18-flash pattern), or three (21-flash pattern) non-target flashes between each target flashes. Online results showed that the 16-flash pattern yielded the lowest classification accuracy among the three patterns. The results also showed that the 18-flash pattern provides a significantly higher information transfer rate (ITR) than the 21-flash pattern; both patterns provide high ITR and high accuracy for all subjects. PMID:22350331

  13. Experimental Platform for Ultra-high Dose Rate FLASH Irradiation of Small Animals Using a Clinical Linear Accelerator

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Schüler, Emil; Trovati, Stefania; King, Gregory

    Purpose: A key factor limiting the effectiveness of radiation therapy is normal tissue toxicity, and recent preclinical data have shown that ultra-high dose rate irradiation (>50 Gy/s, “FLASH”) potentially mitigates this effect. However, research in this field has been strongly limited by the availability of FLASH irradiators suitable for small animal experiments. We present a simple methodologic approach for FLASH electron small animal irradiation with a clinically available linear accelerator (LINAC). Methods and Materials: We investigated the FLASH irradiation potential of a Varian Clinac 21EX in both clinical mode and after tuning of the LINAC. We performed detailed FLUKA Monte Carlomore » and experimental dosimetric characterization at multiple experimental locations within the LINAC head. Results: Average dose rates of ≤74 Gy/s were achieved in clinical mode, and the dose rate after tuning exceeded 900 Gy/s. We obtained 220 Gy/s at 1-cm depth for a >4-cm field size with 90% homogeneity throughout a 2-cm-thick volume. Conclusions: We present an approach for using a clinical LINAC for FLASH irradiation. We obtained dose rates exceeding 200 Gy/s after simple tuning of the LINAC, with excellent dosimetric properties for small animal experiments. This will allow for increased availability of FLASH irradiation to the general research community.« less

  14. Remote collection and analysis of witness reports on flash floods

    NASA Astrophysics Data System (ADS)

    Gourley, J. J.; Erlingis, J. M.; Smith, T. M.; Ortega, K. L.; Hong, Y.

    2010-11-01

    SummaryTypically, flash floods are studied ex post facto in response to a major impact event. A complement to field investigations is developing a detailed database of flash flood events, including minor events and null reports (i.e., where heavy rain occurred but there was no flash flooding), based on public survey questions conducted in near-real time. The Severe hazards analysis and verification experiment (SHAVE) has been in operation at the National Severe Storms Laboratory (NSSL) in Norman, OK, USA during the summers since 2006. The experiment employs undergraduate students to analyse real-time products from weather radars, target specific regions within the conterminous US, and poll public residences and businesses regarding the occurrence and severity of hail, wind, tornadoes, and now flash floods. In addition to providing a rich learning experience for students, SHAVE has also been successful in creating high-resolution datasets of severe hazards used for algorithm and model verification. This paper describes the criteria used to initiate the flash flood survey, the specific questions asked and information entered to the database, and then provides an analysis of results for flash flood data collected during the summer of 2008. It is envisioned that specific details provided by the SHAVE flash flood observation database will complement databases collected by operational agencies (i.e., US National Weather Service Storm Data reports) and thus lead to better tools to predict the likelihood of flash floods and ultimately reduce their impacts on society.

  15. Experimental check of bremsstrahlung dosimetry predictions for 0.75 MeV electrons

    NASA Astrophysics Data System (ADS)

    Sanford, T. W. L.; Halbleib, J. A.; Beezhold, W.

    Bremsstrahlung dose in CaF2 TLDs from the radiation produced by 0.75 MeV electrons incident on Ta/C targets is measured and compared with that calculated via the CYLTRAN Monte Carlo code. The comparison was made to validate the code, which is used to predict and analyze radiation environments of flash X-ray simulators measured by TLDs. Over a wide range of Ta target thicknesses and radiation angles the code is found to agree with the 5% measurements. For Ta thickness near those that optimize the radiation output, however, the code overestimates the radiation dose at small angles. Maximum overprediction is about 14 + or - 5%. The general agreement, nonetheless, gives confidence in using the code at this energy and in the TLD calibration procedure. For the bulk of the measurements, a standard TLD employing a 2.2 mm thick Al equilibrator was used. In this paper we also show that this thickness can significantly attenuate the free-field dose and introduces significant photon buildup in the equalibrator.

  16. Neutral location cues and cost/benefit analysis of visual attention shifts.

    PubMed

    Wright, R D; Richard, C M; McDonald, J J

    1995-12-01

    The effects of location cuing on target responses can be examined by comparing informative and neutral cuing conditions. In particular, the magnitudes of costs of invalid location cuing and of benefits of valid location cuing can be determined by comparing invalid and valid cue responses to location-nonspecific neutral cue responses. Cost/benefit analysis is based on the assumption that neutral baseline measures reflect a general warning effect about the impending target's onset but no other specific target information. The experiments we report were carried out to determine the appropriateness of two baseline measures for cost/benefit analyses of direct (nonsymbolic) location cuing effects. We found that a multiple-cue baseline attenuated the benefits of valid cuing, and that a background-flash baseline arbitrarily attenuated costs or benefits depending on flash intensity. It is proposed that a background flash is the more suitable neutral cue because it is target-location-nonspecific, but that its intensity should be adjusted to elicit a target-onset warning signal of the same magnitude as the location cues with which it will be compared.

  17. Menopausal Hot Flashes and Carotid Intima Media Thickness among Midlife Women

    PubMed Central

    Thurston, Rebecca C.; Chang, Yuefang; Barinas-Mitchell, Emma; Jennings, J. Richard; Landsittel, Doug P.; Santoro, Nanette; von Känel, Roland; Matthews, Karen A.

    2016-01-01

    Background and Purpose There has been a longstanding interest in the role of menopause and its correlates in the development of cardiovascular disease (CVD) in women. Menopausal hot flashes are experienced by most midlife women; emerging data link hot flashes to CVD risk indicators. We tested whether hot flashes, measured via state-of-the-art physiologic methods, were associated with greater subclinical atherosclerosis as assessed by carotid ultrasound. We considered the role of CVD risk factors and estradiol concentrations in these associations. Methods 295 nonsmoking women free of clinical CVD underwent ambulatory physiologic hot flash assessments; a blood draw; and carotid ultrasound measurement of IMT and plaque. Associations between hot flashes and subclinical atherosclerosis were tested in regression models controlling for CVD risk factors and estradiol. Results More frequent physiologic hot flashes were associated with higher carotid intima media thickness [IMT; for each additional hot flash: beta (standard error)=.004(.001), p=.0001; reported hot flash: beta (standard error)=.008(.002), p=.002, multivariable] and plaque [e.g., for each additional hot flash, odds ratio (95% confidence interval) plaque index ≥2=1.07(1.003–1.14, p=.04), relative to no plaque, multivariable] among women reporting daily hot flashes; associations were not accounted for by CVD risk factors or by estradiol. Among women reporting hot flashes, hot flashes accounted for more variance in IMT than most CVD risk factors. Conclusions Among women reporting daily hot flashes, frequent hot flashes may provide information about a woman’s vascular status beyond standard CVD risk factors and estradiol. Frequent hot flashes may mark a vulnerable vascular phenotype among midlife women. PMID:27834746

  18. Hypnosis for Hot Flashes and Associated Symptomsin Women with Breast Cancer.

    PubMed

    Roberts, R Lynae; Na, Hyeji; Yek, Ming Hwei; Elkins, Gary

    2017-10-01

    Women with breast cancer experience a host of physical and psychological symptoms, including hot flashes, sleep difficulties, anxiety, and depression. Therefore, treatment for women with breast cancer should target these symptoms and be individualized to patients' specific presentations. The current article reviews the common symptoms associated with breast cancer in women, then examines clinical hypnosis as a treatment for addressing these symptoms and improving the quality of life of women with breast cancer. Clinical hypnosis is an effective, nonpharmaceutical treatment for hot flashes and addressing many symptoms typically experienced by breast cancer patients. A case example is provided to illustrate the use of clinical hypnosis for the treatment of hot flashes with a patient with breast cancer.

  19. CFS MATLAB toolbox: An experiment builder for continuous flash suppression (CFS) task.

    PubMed

    Nuutinen, Mikko; Mustonen, Terhi; Häkkinen, Jukka

    2017-09-15

    CFS toolbox is an open-source collection of MATLAB functions that utilizes PsychToolbox-3 (PTB-3). It is designed to allow a researcher to create and run continuous flash suppression experiments using a variety of experimental parameters (i.e., stimulus types and locations, noise characteristics, and experiment window settings). In a CFS experiment, one of the eyes at a time is presented with a dynamically changing noise pattern, while the other eye is concurrently presented with a static target stimulus, such as a Gabor patch. Due to the strong interocular suppression created by the dominant noise pattern mask, the target stimulus is rendered invisible for an extended duration. Very little knowledge of MATLAB is required for using the toolbox; experiments are generated by modifying csv files with the required parameters, and result data are output to text files for further analysis. The open-source code is available on the project page under a Creative Commons License ( http://www.mikkonuutinen.arkku.net/CFS_toolbox/ and https://bitbucket.org/mikkonuutinen/cfs_toolbox ).

  20. Simulations of bremsstrahlung emission in ultra-intense laser interactions with foil targets

    NASA Astrophysics Data System (ADS)

    Vyskočil, Jiří; Klimo, Ondřej; Weber, Stefan

    2018-05-01

    Bremsstrahlung emission from interactions of short ultra-intense laser pulses with solid foils is studied using particle-in-cell (PIC) simulations. A module for simulating bremsstrahlung has been implemented in the PIC loop to self-consistently account for the dynamics of the laser–plasma interaction, plasma expansion, and the emission of gamma ray photons. This module made it possible to study emission from thin targets, where refluxing of hot electrons plays an important role. It is shown that the angular distribution of the emitted photons exhibits a four-directional structure with the angle of emission decreasing with the increase of the width of the target. Additionally, a collimated forward flash consisting of high energy photons has been identified in thin targets. The conversion efficiency of the energy of the laser pulse to the energy of the gamma rays rises with both the driving pulse intensity, and the thickness of the target. The amount of gamma rays also increases with the atomic number of the target material, despite a lower absorption of the driving laser pulse. The angular spectrum of the emitted gamma rays is directly related to the increase of hot electron divergence during their refluxing and its measurement can be used in experiments to study this process.

  1. Blast-Wave Generation and Propagation in Rapidly Heated Laser-Irradiated Targets

    NASA Astrophysics Data System (ADS)

    Ivancic, S. T.; Stillman, C. R.; Nilson, P. M.; Solodov, A. A.; Froula, D. H.

    2017-10-01

    Time-resolved extreme ultraviolet (XUV) spectroscopy was used to study the creation and propagation of a >100-Mbar blast wave in a target irradiated by an intense (>1018WWcm2 cm2) laser pulse. Blast waves provide a platform to generate immense pressures in the laboratory. A temporal double flash of XUV radiation was observed when viewing the rear side of the target, which is attributed to the emergence of a blast wave following rapid heating by a fast-electron beam generated from the laser pulse. The time-history of XUV emission in the photon energy range of 50 to 200 eV was recorded with an x-ray streak camera with 7-ps temporal resolution. The heating and expansion of the target was simulated with an electron transport code coupled to 1-D radiation-hydrodynamics simulations. The temporal delay between the two flashes measured in a systematic study of target thickness and composition was found to evolve in good agreement with a Sedov-Taylor blast-wave solution. This material is based upon work supported by the Department of Energy National Nuclear Security Administration under Award Number DE-NA0001944 and Department of Energy Office of Science Award Number DE-SC-0012317.

  2. Impact Flash Physics: Modeling and Comparisons With Experimental Results

    NASA Astrophysics Data System (ADS)

    Rainey, E.; Stickle, A. M.; Ernst, C. M.; Schultz, P. H.; Mehta, N. L.; Brown, R. C.; Swaminathan, P. K.; Michaelis, C. H.; Erlandson, R. E.

    2015-12-01

    Hypervelocity impacts frequently generate an observable "flash" of light with two components: a short-duration spike due to emissions from vaporized material, and a long-duration peak due to thermal emissions from expanding hot debris. The intensity and duration of these peaks depend on the impact velocity, angle, and the target and projectile mass and composition. Thus remote sensing measurements of planetary impact flashes have the potential to constrain the properties of impacting meteors and improve our understanding of impact flux and cratering processes. Interpreting impact flash measurements requires a thorough understanding of how flash characteristics correlate with impact conditions. Because planetary-scale impacts cannot be replicated in the laboratory, numerical simulations are needed to provide this insight for the solar system. Computational hydrocodes can produce detailed simulations of the impact process, but they lack the radiation physics required to model the optical flash. The Johns Hopkins University Applied Physics Laboratory (APL) developed a model to calculate the optical signature from the hot debris cloud produced by an impact. While the phenomenology of the optical signature is understood, the details required to accurately model it are complicated by uncertainties in material and optical properties and the simplifications required to numerically model radiation from large-scale impacts. Comparisons with laboratory impact experiments allow us to validate our approach and to draw insight regarding processes that occur at all scales in impact events, such as melt generation. We used Sandia National Lab's CTH shock physics hydrocode along with the optical signature model developed at APL to compare with a series of laboratory experiments conducted at the NASA Ames Vertical Gun Range. The experiments used Pyrex projectiles to impact pumice powder targets with velocities ranging from 1 to 6 km/s at angles of 30 and 90 degrees with respect to horizontal. High-speed radiometer measurements were made of the time-dependent impact flash at wavelengths of 350-1100 nm. We will present comparisons between these measurements and the output of APL's model. The results of this validation allow us to determine basic relationships between observed optical signatures and impact conditions.

  3. Hot Flashes and Carotid Intima Media Thickness among Midlife Women

    PubMed Central

    Thurston, Rebecca C.; Sutton-Tyrrell, Kim; Everson-Rose, Susan A.; Hess, Rachel; Powell, Lynda H.; Matthews, Karen A.

    2010-01-01

    Objective Emerging evidence suggests associations between menopausal hot flashes and cardiovascular risk. Whether hot flashes are associated with intima media thickness (IMT) or IMT changes over time is unknown. We hypothesized that reported hot flashes would be associated with greater IMT cross-sectionally and with greater IMT progression over two years. Methods Participants were 432 women ages 45-58 at baseline participating in SWAN Heart, an ancillary study to the Study of Women's Health Across the Nation. Measures at the SWAN Heart baseline and follow-up visit two years later included a carotid artery ultrasound, reported hot flashes (past two weeks: none, 1-5, ≥6 days), and a blood sample for measurement of estradiol. Results Women reporting hot flashes ≥6 days in the prior two weeks had significantly higher IMT than women without hot flashes at baseline (mean difference(SE), mm =0.02(0.01), p=0.03) and follow-up (mean difference(SE), mm =0.02(0.01), p=0.04) visits, controlling for demographic factors and cardiovascular risk factors. Reporting hot flashes at both study visits was associated with higher follow-up IMT relative to reporting hot flashes at neither visit (mean difference(SE), mm=0.03(0.01), p=0.03). Associations between hot flashes and IMT largely remained after adjusting for estradiol. An interaction between hot flashes and obesity status was observed (p=0.05) such that relations between hot flashes and IMT were observed principally among overweight/obese women. Hot flashes were not associated with IMT progression. Conclusions These findings provided some indication that women reporting hot flashes ≥6 days in the prior two weeks may have higher IMT than women without hot flashes, particularly for women who are overweight or obese. Further work should determine whether hot flashes mark adverse underlying vascular changes. PMID:21242820

  4. The influence of cognitive load on spatial search performance.

    PubMed

    Longstaffe, Kate A; Hood, Bruce M; Gilchrist, Iain D

    2014-01-01

    During search, executive function enables individuals to direct attention to potential targets, remember locations visited, and inhibit distracting information. In the present study, we investigated these executive processes in large-scale search. In our tasks, participants searched a room containing an array of illuminated locations embedded in the floor. The participants' task was to press the switches at the illuminated locations on the floor so as to locate a target that changed color when pressed. The perceptual salience of the search locations was manipulated by having some locations flashing and some static. Participants were more likely to search at flashing locations, even when they were explicitly informed that the target was equally likely to be at any location. In large-scale search, attention was captured by the perceptual salience of the flashing lights, leading to a bias to explore these targets. Despite this failure of inhibition, participants were able to restrict returns to previously visited locations, a measure of spatial memory performance. Participants were more able to inhibit exploration to flashing locations when they were not required to remember which locations had previously been visited. A concurrent digit-span memory task further disrupted inhibition during search, as did a concurrent auditory attention task. These experiments extend a load theory of attention to large-scale search, which relies on egocentric representations of space. High cognitive load on working memory leads to increased distractor interference, providing evidence for distinct roles for the executive subprocesses of memory and inhibition during large-scale search.

  5. High-speed photography and stress-gauge studies of the impact and penetration of plates by rods

    NASA Astrophysics Data System (ADS)

    Bourne, Neil K.; Forde, Lucy C.; Field, John E.

    1997-05-01

    There has been much study of the penetration of semi- infinite and finite thickness targets by long rods at normal incidence. The effects of oblique impact have received relatively little attention and techniques of modeling are thus less developed. It was decided to conduct an experimental investigation of the effects of rod penetration at various angles of impact at zero yaw. The rods were mounted in a reverse ballistic configuration so that their response could be quantified through the impact. Scale copper, mild steel and tungsten alloy rods with hemispherical ends were suspended at the end of the barrel of a 50 mm gas gun at the University of Cambridge. The rods were instrumented with embedded manganin piezoresistive stress gauges. Annealed aluminum, duraluminum and rolled homogeneous armor plates of varying thickness and obliquity were fired at the rods at one of two velocities. The impacts were backlit and photographed with an Ultranac FS501 programmable high-speed camera operated in framing mode. The gauges were monitored using a 2 GH s-1 storage oscilloscope. Rods and plates were recovered after the impact for microstructural examination. Additionally, penetration of borosilicate glass targets was investigated using high-speed photography and a localized Xe flash source and schlieren optics. Additional data was obtained by the use of flash X-ray. Waves and damage were visualized in the glass. High-speed sequences and gauge records are presented showing the mechanisms of penetration and exit seen during impact.

  6. Adaptive P300 based control system

    PubMed Central

    Jin, Jing; Allison, Brendan Z.; Sellers, Eric W.; Brunner, Clemens; Horki, Petar; Wang, Xingyu; Neuper, Christa

    2015-01-01

    An adaptive P300 brain-computer interface (BCI) using a 12 × 7 matrix explored new paradigms to improve bit rate and accuracy. During online use, the system adaptively selects the number of flashes to average. Five different flash patterns were tested. The 19-flash paradigm represents the typical row/column presentation (i.e., 12 columns and 7 rows). The 9- and 14-flash A & B paradigms present all items of the 12 × 7 matrix three times using either nine or 14 flashes (instead of 19), decreasing the amount of time to present stimuli. Compared to 9-flash A, 9-flash B decreased the likelihood that neighboring items would flash when the target was not flashing, thereby reducing interference from items adjacent to targets. 14-flash A also reduced adjacent item interference and 14-flash B additionally eliminated successive (double) flashes of the same item. Results showed that accuracy and bit rate of the adaptive system were higher than the non-adaptive system. In addition, 9- and 14-flash B produced significantly higher performance than their respective A conditions. The results also show the trend that the 14-flash B paradigm was better than the 19-flash pattern for naïve users. PMID:21474877

  7. CD uniformity control for thick resist process

    NASA Astrophysics Data System (ADS)

    Huang, Chi-hao; Liu, Yu-Lin; Wang, Weihung; Yang, Mars; Yang, Elvis; Yang, T. H.; Chen, K. C.

    2017-03-01

    In order to meet the increasing storage capacity demand and reduce bit cost of NAND flash memories, 3D stacked flash cell array has been proposed. In constructing 3D NAND flash memories, the higher bit number per area is achieved by increasing the number of stacked layers. Thus the so-called "staircase" patterning to form electrical connection between memory cells and word lines has become one of the primarily critical processes in 3D memory manufacture. To provide controllable critical dimension (CD) with good uniformity involving thick photo-resist has also been of particular concern for staircase patterning. The CD uniformity control has been widely investigated with relatively thinner resist associated with resolution limit dimension but thick resist coupling with wider dimension. This study explores CD uniformity control associated with thick photo-resist processing. Several critical parameters including exposure focus, exposure dose, baking condition, pattern size and development recipe, were found to strongly correlate with the thick photo-resist profile accordingly affecting the CD uniformity control. To minimize the within-wafer CD variation, the slightly tapered resist profile is proposed through well tailoring the exposure focus and dose together with optimal development recipe. Great improvements on DCD (ADI CD) and ECD (AEI CD) uniformity as well as line edge roughness were achieved through the optimization of photo resist profile.

  8. Spatial decoupling of targets and flashing stimuli for visual brain-computer interfaces

    NASA Astrophysics Data System (ADS)

    Waytowich, Nicholas R.; Krusienski, Dean J.

    2015-06-01

    Objective. Recently, paradigms using code-modulated visual evoked potentials (c-VEPs) have proven to achieve among the highest information transfer rates for noninvasive brain-computer interfaces (BCIs). One issue with current c-VEP paradigms, and visual-evoked paradigms in general, is that they require direct foveal fixation of the flashing stimuli. These interfaces are often visually unpleasant and can be irritating and fatiguing to the user, thus adversely impacting practical performance. In this study, a novel c-VEP BCI paradigm is presented that attempts to perform spatial decoupling of the targets and flashing stimuli using two distinct concepts: spatial separation and boundary positioning. Approach. For the paradigm, the flashing stimuli form a ring that encompasses the intended non-flashing targets, which are spatially separated from the stimuli. The user fixates on the desired target, which is classified using the changes to the EEG induced by the flashing stimuli located in the non-foveal visual field. Additionally, a subset of targets is also positioned at or near the stimulus boundaries, which decouples targets from direct association with a single stimulus. This allows a greater number of target locations for a fixed number of flashing stimuli. Main results. Results from 11 subjects showed practical classification accuracies for the non-foveal condition, with comparable performance to the direct-foveal condition for longer observation lengths. Online results from 5 subjects confirmed the offline results with an average accuracy across subjects of 95.6% for a 4-target condition. The offline analysis also indicated that targets positioned at or near the boundaries of two stimuli could be classified with the same accuracy as traditional superimposed (non-boundary) targets. Significance. The implications of this research are that c-VEPs can be detected and accurately classified to achieve comparable BCI performance without requiring potentially irritating direct foveation of flashing stimuli. Furthermore, this study shows that it is possible to increase the number of targets beyond the number of stimuli without degrading performance. Given the superior information transfer rate of c-VEP paradigms, these results can lead to the development of more practical and ergonomic BCIs.

  9. floodX: urban flash flood experiments monitored with conventional and alternative sensors

    NASA Astrophysics Data System (ADS)

    Moy de Vitry, Matthew; Dicht, Simon; Leitão, João P.

    2017-09-01

    The data sets described in this paper provide a basis for developing and testing new methods for monitoring and modelling urban pluvial flash floods. Pluvial flash floods are a growing hazard to property and inhabitants' well-being in urban areas. However, the lack of appropriate data collection methods is often cited as an impediment for reliable flood modelling, thereby hindering the improvement of flood risk mapping and early warning systems. The potential of surveillance infrastructure and social media is starting to draw attention for this purpose. In the floodX project, 22 controlled urban flash floods were generated in a flood response training facility and monitored with state-of-the-art sensors as well as standard surveillance cameras. With these data, it is possible to explore the use of video data and computer vision for urban flood monitoring and modelling. The floodX project stands out as the largest documented flood experiment of its kind, providing both conventional measurements and video data in parallel and at high temporal resolution. The data set used in this paper is available at https://doi.org/10.5281/zenodo.830513.

  10. Numerical Modeling of Complex Targets for High-Energy- Density Experiments with Ion Beams and other Drivers

    DOE PAGES

    Koniges, Alice; Liu, Wangyi; Lidia, Steven; ...

    2016-04-01

    We explore the simulation challenges and requirements for experiments planned on facilities such as the NDCX-II ion accelerator at LBNL, currently undergoing commissioning. Hydrodynamic modeling of NDCX-II experiments include certain lower temperature effects, e.g., surface tension and target fragmentation, that are not generally present in extreme high-energy laser facility experiments, where targets are completely vaporized in an extremely short period of time. Target designs proposed for NDCX-II range from metal foils of order one micron thick (thin targets) to metallic foam targets several tens of microns thick (thick targets). These high-energy-density experiments allow for the study of fracture as wellmore » as the process of bubble and droplet formation. We incorporate these physics effects into a code called ALE-AMR that uses a combination of Arbitrary Lagrangian Eulerian hydrodynamics and Adaptive Mesh Refinement. Inclusion of certain effects becomes tricky as we must deal with non-orthogonal meshes of various levels of refinement in three dimensions. A surface tension model used for droplet dynamics is implemented in ALE-AMR using curvature calculated from volume fractions. Thick foam target experiments provide information on how ion beam induced shock waves couple into kinetic energy of fluid flow. Although NDCX-II is not fully commissioned, experiments are being conducted that explore material defect production and dynamics.« less

  11. Lasers' spectral and temporal profile can affect visual glare disability.

    PubMed

    Beer, Jeremy M A; Freeman, David A

    2012-12-01

    Experiments measured the effects of laser glare on visual orientation and motion perception. Laser stimuli were varied according to spectral composition and temporal presentation as subjects identified targets' tilt (Experiment 1) and movement (Experiment 2). The objective was to determine whether the glare parameters would alter visual disruption. Three spectral profiles (monochromatic Green vs. polychromatic White vs. alternating Red-Green) were used to produce a ring of laser glare surrounding a target. Two experiments were performed to measure the minimum contrast required to report target orientation or motion direction. The temporal glare profile was also varied: the ring was illuminated either continuously or discontinuously. Time-averaged luminance of the glare stimuli was matched across all conditions. In both experiments, threshold (deltaL) values were approximately 0.15 log units higher in monochromatic Green than in polychromatic White conditions. In Experiment 2 (motion identification), thresholds were approximately 0.17 log units higher in rapidly flashing (6, 10, or 14 Hz) than in continuous exposure conditions. Monochromatic extended-source laser glare disrupted orientation and motion identification more than polychromatic glare. In the motion task, pulse trains faster than 6 Hz (but below flicker fusion) elevated thresholds more than continuous glare with the same time-averaged luminance. Under these conditions, alternating the wavelength of monochromatic glare over time did not aggravate disability relative to green-only glare. Repetitively flashing monochromatic laser glare induced occasional episodes of impaired motion identification, perhaps resulting from cognitive interference. Interference speckle might play a role in aggravating monochromatic glare effects.

  12. Constitutive relationships and physical basis of fault strength due to flash heating

    USGS Publications Warehouse

    Beeler, N.M.; Tullis, T.E.; Goldsby, D.L.

    2008-01-01

    We develop a model of fault strength loss resulting from phase change at asperity contacts due to flash heating that considers a distribution of contact sizes and nonsteady state evolution of fault strength with displacement. Laboratory faulting experiments conducted at high sliding velocities, which show dramatic strength reduction below the threshold for bulk melting, are well fit by the model. The predicted slip speed for the onset of weakening is in the range of 0.05 to 2 m/s, qualitatively consistent with the limited published observations. For this model, earthquake stress drops and effective shear fracture energy should be linearly pressure-dependent, whereas the onset speed may be pressure-independent or weakly pressure-dependent. On the basis of the theory, flash weakening is expected to produce large dynamic stress drops, small effective shear fracture energy, and undershoot. Estimates of the threshold slip speed, stress drop, and fracture energy are uncertain due to poor knowledge of the average ontact dimension, shear zone thickness and gouge particle size at seismogenic depths. Copyright 2008 by the American Geophysical Union.

  13. FLASH LIDAR Based Relative Navigation

    NASA Technical Reports Server (NTRS)

    Brazzel, Jack; Clark, Fred; Milenkovic, Zoran

    2014-01-01

    Relative navigation remains the most challenging part of spacecraft rendezvous and docking. In recent years, flash LIDARs, have been increasingly selected as the go-to sensors for proximity operations and docking. Flash LIDARS are generally lighter and require less power that scanning Lidars. Flash LIDARs do not have moving parts, and they are capable of tracking multiple targets as well as generating a 3D map of a given target. However, there are some significant drawbacks of Flash Lidars that must be resolved if their use is to be of long-term significance. Overcoming the challenges of Flash LIDARs for navigation-namely, low technology readiness level, lack of historical performance data, target identification, existence of false positives, and performance of vision processing algorithms as intermediaries between the raw sensor data and the Kalman filter-requires a world-class testing facility, such as the Lockheed Martin Space Operations Simulation Center (SOSC). Ground-based testing is a critical step for maturing the next-generation flash LIDAR-based spacecraft relative navigation. This paper will focus on the tests of an integrated relative navigation system conducted at the SOSC in January 2014. The intent of the tests was to characterize and then improve the performance of relative navigation, while addressing many of the flash LIDAR challenges mentioned above. A section on navigation performance and future recommendation completes the discussion.

  14. Reconstruction of Axial Energy Deposition in Magnetic Liner Inertial Fusion Based on PECOS Shadowgraph Unfolds Using the AMR Code FLASH

    NASA Astrophysics Data System (ADS)

    Adams, Marissa; Jennings, Christopher; Slutz, Stephen; Peterson, Kyle; Gourdain, Pierre; U. Rochester-Sandia Collaboration

    2017-10-01

    Magnetic Liner Inertial Fusion (MagLIF) experiments incorporate a laser to preheat a deuterium filled capsule before compression via a magnetically imploding liner. In this work, we focus on the blast wave formed in the fuel during the laser preheat component of MagLIF, where approximately 1kJ of energy is deposited in 3ns into the capsule axially before implosion. To model blast waves directly relevant to experiments such as MagLIF, we inferred deposited energy from shadowgraphy of laser-only experiments preformed at the PECOS target chamber using the Z-Beamlet laser. These energy profiles were used to initialize 2-dimensional simulations using by the adaptive mesh refinement code FLASH. Gradients or asymmetries in the energy deposition may seed instabilities that alter the fuel's distribution, or promote mix, as the blast wave interacts with the liner wall. The AMR capabilities of FLASH allow us to study the development and dynamics of these instabilities within the fuel and their effect on the liner before implosion. Sandia Natl Labs is managed by NTES of Sandia, LLC., a subsidiary of Honeywell International, Inc, for the U.S. DOEs NNSA under contract DE-NA0003525.

  15. Effect of starting point formation on the crystallization of amorphous silicon films by flash lamp annealing

    NASA Astrophysics Data System (ADS)

    Sato, Daiki; Ohdaira, Keisuke

    2018-04-01

    We succeed in the crystallization of hydrogenated amorphous silicon (a-Si:H) films by flash lamp annealing (FLA) at a low fluence by intentionally creating starting points for the trigger of explosive crystallization (EC). We confirm that a partly thick a-Si part can induce the crystallization of a-Si films. A periodic wavy structure is observed on the surface of polycrystalline silicon (poly-Si) on and near the thick parts, which is a clear indication of the emergence of EC. Creating partly thick a-Si parts can thus be effective for the control of the starting point of crystallization by FLA and can realize the crystallization of a-Si with high reproducibility. We also compare the effects of creating thick parts at the center and along the edge of the substrates, and a thick part along the edge of the substrates leads to the initiation of crystallization at a lower fluence.

  16. Porosity Measurement in Laminated Composites by Thermography and FEA

    NASA Technical Reports Server (NTRS)

    Chu, Tsuchin Philip; Russell, Samuel S.; Walker, James L.; Munafo, Paul M. (Technical Monitor)

    2001-01-01

    This paper presents the correlation between the through-thickness thermal diffusivity and the porosity of composites. Finite element analysis (FEA) was used to determine the transient thermal response of composites that were subjected to laser heating. A series of finite element models were built and thermal responses for isotropic and orthographic materials with various thermal diffusivities subjected to different heating conditions were investigated. Experiments were conducted to verify the models and to estimate the unknown parameters such as the amount of heat flux. The analysis and experimental results show good correlation between thermal diffusivity and porosity in the composite materials. They also show that both laser and flash heating can be used effectively to obtain thermal diffusivity. The current infrared thermography system is developed for use with flash heating. The laser heating models and the FEA results can provide useful tools to develop practical thermal diffusivity measurement scheme using laser heat.

  17. The Function of Consciousness in Multisensory Integration

    ERIC Educational Resources Information Center

    Palmer, Terry D.; Ramsey, Ashley K.

    2012-01-01

    The function of consciousness was explored in two contexts of audio-visual speech, cross-modal visual attention guidance and McGurk cross-modal integration. Experiments 1, 2, and 3 utilized a novel cueing paradigm in which two different flash suppressed lip-streams cooccured with speech sounds matching one of these streams. A visual target was…

  18. Conspicuity of target lights: The influence of color

    NASA Technical Reports Server (NTRS)

    Connors, M. M.

    1975-01-01

    The conspicuity (or attention-getting qualities) were investigated of foveally-equated, colored lights, when seen against a star background. Subjects who were periodically engaged in a distracting cockpit task were required to search a large visual field and report the appearance of a target light as quickly as possible. Targets were red, yellow, white, green, and blue, and appeared either as steady or as flashing lights. Results indicate that red targets were missed more frequently and responded to more slowly than lights of other hues. Yellow targets were acquired more slowly than white, green, or blue targets; responses to white targets were significantly slower than responses to green or blue targets. In general, flashing lights were superior to steady lights, but this was not found for all hues. For red, the 2 Hz flash was superior to all other flash rates and to the steady light, none of which differed significantly from each other. Over all hues, conspicuity was found to peak at 2-3 Hz. Response time was found to be fastest, generally, for targets appearing at between 3 and 8 from the center of the visual field. However, this pattern was not repeated for every hue. Conspicuity response times suggest a complex relationship between hue and position in the visual field that is explained only partially by retinal sensitivity.

  19. Improved identification of the palmar fibrocartilage of the navicular bone with saline magnetic resonance bursography.

    PubMed

    Schramme, Michael; Kerekes, Zoltan; Hunter, Stuart; Nagy, Krisztina; Pease, Anthony

    2009-01-01

    Fibrocartilage degeneration is the earliest pathologic finding in navicular disease but remains difficult to detect, even with magnetic resonance (MR) imaging. We hypothesized that injection of the navicular bursa with saline would improve accuracy of MR imaging evaluation of palmar fibrocartilage. Thoracic limbs were collected from 11 horses within 6 h of death. Imaging was performed with a 1.5 T magnet using sagittal 2D proton density and transverse 3D FLASH sequences with fat saturation. For the purpose of determining sensitivity and specificity of the MR images, fibrocartilage was classified as normal or abnormal, based on combination of the findings of gross and microscopic pathology. Thickness of fibrocartilage was measured on histologic sections and corresponding transverse FLASH MR images before and after injection of saline. A paired Student's t-test was used for comparison of measurements. Partial thickness fibrocartilage loss was present in 6 of 22 limbs. Sensitivity of precontrast MR images for detection of lesions was 100% while specificity was 6%. Saline MR arthrography resulted in both sensitivity and specificity of 100% based on consensus review. Mean histologic fibrocartilage thickness was 0.75 +/- 0.12 mm. Mean fibrocartilage thickness on precontrast transverse FLASH images was 0.93 +/- 0.065 and 0.73 +/- 0.09 mm on postsaline images. The histologic cartilage thickness was signficantly different from that in precontrast images (P<0.001) but not in images acquired after saline injection (P = 0.716). Based on our results, and using pulse sequences as described herein, navicular fibrocartilage can only be evaluated reliably for the presence of partial thickness lesions after intrabursal injection of saline.

  20. Dynamic thermal tomography for nondestructive inspection of aging aircraft

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Del Grande, N.K.; Dolan, K.W.; Durbin, P.F.

    1993-11-01

    The authors apply dual-band infrared (DBIR) imaging as a dynamic thermal tomography tool for wide area inspection of a Boeing 737 aircraft and several Boeing KC-135 aircraft panels. The analyses are discussed in this report. After flash-heating the aircraft skin, they record synchronized DBIR images every 40 ms, from onset to 8 seconds after the heat flash. They analyze selective DBIR image ratios which enhance surface temperature contrast and remove surface-emissivity clutter. The Boeing 737 and KC-135 aircraft fuselage panels have varying percent thickness losses from corrosion. They established the correlation of percent thickness loss with surface temperature rise (abovemore » ambient) for a partially corroded F-18 wing box structure and several aluminum plates which had 6 to 60% thickness losses at milled flat-bottom hole sites. Based on this correlation, lap splice temperatures rise 1C per 24 {plus_minus} 5% material loss at 0.4 s after the heat flash. They tabulate and map corrosion-related percent thickness loss effects for the riveted Boeing 737, and the riveted Boeing KKC-135. They map the fuselage composite thermal inertia, based on the (inverse) slope of the surface temperature versus inverse square root of time. Composite thermal inertia maps characterized shallow skin defects within the lap splice at early times (< 0.3 s) and deeper skin defects within the lap splice at late times (> 0.4 s). Late time composite thermal inertia maps depict where corrosion-related thickness losses occur (e.g., on the inside of the Boeing 737 lap splice, beneath the galley and the latrine). Lap splice sites on a typical Boeing KC-135 panel with low composite thermal inertia values had high skin-thickness losses from corrosion.« less

  1. An Artistic Exploration of Inattention Blindness†

    PubMed Central

    Levy, Ellen K.

    2012-01-01

    An experiment about inattention blindness was conducted within the context of an art exhibition as opposed to a laboratory context in order to investigate the potential of art as a vehicle to study attention and its disorders. The project utilized a flash animation, Stealing Attention, that was modeled after the movie by Simons and Chabris (1999) but with significant experimental differences, involving context and staging, the emotional salience of the objects depicted, and the prior art viewing experience of participants. The study involved two components: observing if viewers watching an animation in a gallery could be distracted from noticing the disappearance of stolen museum antiquities (the targets) by the overlaid flashing images of a card game (the distractors) and then observing whether repetition of the depicted targets throughout the gallery installation could facilitate a re-direction of attention that allowed viewers to perceive the targets not initially noted in the animation. My findings were that, after viewing the entire installation and then re-viewing the animation, 64% of the viewers who did not initially remark on the targets in the animation were then able to see them. The discussion elaborates on these findings and then considers ways in which the implications of inattention blindness paradigms might be more fully rendered by uniting insights from the two disciplines of art and neuroscience than by either alone. PMID:22232588

  2. Liquid crystals as on-demand, variable thickness targets for intense laser applications

    NASA Astrophysics Data System (ADS)

    Poole, Patrick L.; Andereck, C. David; Schumacher, Douglass W.

    2014-10-01

    Laser-based ion acceleration is currently studied for its applications to advanced imaging and cancer therapy, among others. Targets for these and other high-intensity laser experiments are often small metallic foils with few to sub-micron thicknesses, where the thickness determines the physics of the dominant acceleration mechanism. We have developed liquid crystal films that preserve the planar target geometry advantageous to ion acceleration schemes while providing on-demand thickness variation between 50 and 5000 nm. This thickness control is obtained in part by varying the temperature at which films are formed, which governs the phase (and hence molecular ordering) of the liquid crystal material. Liquid crystals typically have vapor pressures well below the 10-6 Torr operating pressures of intense laser target chambers, and films formed in air maintain their thickness during chamber evacuation. Additionally, the minute volume that comprises each film makes the cost of each target well below one cent, in stark contrast to many standard solid targets. We will discuss the details of liquid crystal film control and formation, as well as characterization experiments performed at the Scarlet laser facility. This work was performed with support from DARPA and NNSA.

  3. Pair production by high intensity picosecond laser interacting with thick solid target at XingGuangIII

    NASA Astrophysics Data System (ADS)

    Wu, Yuchi; Dong, Kegong; Yan, Yonghong; Zhu, Bin; Zhang, Tiankui; Chen, Jia; Yu, Minghai; Tan, Fang; Wang, Shaoyi; Han, Dan; Lu, Feng; Gu, Yuqiu

    2017-06-01

    An experiment for pair production by high intensity laser irradiating thick solid targets is present. The experiment used picosecond beam of the XingGuangIII laser facility, with intensities up to several 1019 W/cm2, pulse durations about 0.8 ps and laser energies around 120 J. Pairs were generated from 1 mm-thick tantalum disk targets with different diameters from 1 mm to 10 mm. Energy spectra of hot electron from targetrear surface represent a Maxwellian distribution and obey a scaling of ∼(Iλ2)0.5. Large quantity of positrons were observed at the target rear normal direction with a yield up to 2.8 × 109 e+/sr. Owing to the target rear surface sheath field, the positrons behave as a quasi-monoenergetic beam with peak energy of several MeV. Our experiment shows that the peak energy of positron beam is inversely proportional to the target diameter.

  4. Multi- and unisensory visual flash illusions.

    PubMed

    Courtney, Jon R; Motes, Michael A; Hubbard, Timothy L

    2007-01-01

    The role of stimulus structure in multisensory and unisensory interactions was examined. When a flash (17 ms) was accompanied by multiple tones (each 7 ms, SOA < or =100 ms) multiple flashes were reported, and this effect has been suggested to reflect the role of stimulus continuity in multisensory interactions. In experiments 1 and 2 we examined if stimulus continuity would affect concurrently presented stimuli. When a relatively longer flash (317 ms) was accompanied by multiple tones (each 7 ms), observers reported perceiving multiple flashes. In experiment 3 we tested whether a flash presented near fixation would induce an illusory flash further in the periphery. One flash (17 ms) presented 5 degrees below fixation was reported as multiple flashes if presented with two flashes (each 17 ms, SOA =100 ms) 2 degrees above fixation. The extent to which these data support a phenomenological continuity principle and whether this principle applies to unisensory perception is discussed.

  5. Identification of Soldier Behaviors Associated with Search and Target Acquisition (STA)

    DTIC Science & Technology

    2010-05-01

    specifically concentrated on representing Soldier and small unit behavior engaging "non-acquired" targets and "non-standard" entities, such as: muzzle ...Forces Are Targeting (e.g., weapon orientation, bullet impacts) Area Where Fire Coming From (e.g., muzzle Flash) Target Handoff...Surveys Cue Average Sum* Participants Muzzle Flash 7.51 34 Hostile Behaviors 7.35 40 Outgoing Fire 7.22 18 Suspicious Behaviors/Activities 6.91

  6. The role of visual attention in multiple object tracking: evidence from ERPs.

    PubMed

    Doran, Matthew M; Hoffman, James E

    2010-01-01

    We examined the role of visual attention in the multiple object tracking (MOT) task by measuring the amplitude of the N1 component of the event-related potential (ERP) to probe flashes presented on targets, distractors, or empty background areas. We found evidence that visual attention enhances targets and suppresses distractors (Experiment 1 & 3). However, we also found that when tracking load was light (two targets and two distractors), accurate tracking could be carried out without any apparent contribution from the visual attention system (Experiment 2). Our results suggest that attentional selection during MOT is flexibly determined by task demands as well as tracking load and that visual attention may not always be necessary for accurate tracking.

  7. Numerical design of a magnetized turbulence experiment at the National Ignition Facility

    NASA Astrophysics Data System (ADS)

    Feister, Scott; Tzeferacos, Petros; Meinecke, Jena; Bott, Archie; Caprioli, Damiano; Laune, Jt; Bell, Tony; Casner, Alexis; Koenig, Michel; Li, Chikang; Miniati, Francesco; Petrasso, Richard; Remington, Bruce; Reville, Brian; Ross, J. Steven; Ryu, Dongsu; Ryutov, Dmitri; Sio, Hong; Turnbull, David; Zylstra, Alex; Schekochihin, Alexander; Froula, Dustin; Park, Hye-Sook; Lamb, Don; Gregori, Gianluca

    2017-10-01

    The origin and amplification of magnetic fields remains an active astrophysical research topic. We discuss design (using three-dimensional FLASH simulations) of a magnetized turbulence experiment at the National Ignition Facility (NIF). NIF lasers drive together two counter-propagating plasma flows to form a hot, turbulent plasma at the center. In the simulations, plasma temperatures are high enough to reach super-critical values of magnetic Reynolds number (Rm). Biermann battery seed magnetic fields (generated during laser-target interaction) are advected into the turbulent region and amplified by fluctuation dynamo in the above-unity Prandtl number regime. Plasma diagnostics are modeled with FLASH for planning and direct comparison with NIF experimental data. This work was supported in part at the University of Chicago by the DOE NNSA, the DOE Office of Science, and the NSF. The numerical simulations were conducted at ALCF's Mira under the auspices of the DOE Office of Science ALCC program.

  8. In2Ga2ZnO7 oxide semiconductor based charge trap device for NAND flash memory.

    PubMed

    Hwang, Eun Suk; Kim, Jun Shik; Jeon, Seok Min; Lee, Seung Jun; Jang, Younjin; Cho, Deok-Yong; Hwang, Cheol Seong

    2018-04-01

    The programming characteristics of charge trap flash memory device adopting amorphous In 2 Ga 2 ZnO 7 (a-IGZO) oxide semiconductors as channel layer were evaluated. Metal-organic chemical vapor deposition (MOCVD) and RF-sputtering processes were used to grow a 45 nm thick a-IGZO layer on a 20 nm thick SiO 2 (blocking oxide)/p ++ -Si (control gate) substrate, where 3 nm thick atomic layer deposited Al 2 O 3 (tunneling oxide) and 5 nm thick low-pressure CVD Si 3 N 4 (charge trap) layers were intervened between the a-IGZO and substrate. Despite the identical stoichiometry and other physicochemical properties of the MOCVD and sputtered a-IGZO, a much faster programming speed of MOCVD a-IGZO was observed. A comparable amount of oxygen vacancies was found in both MOCVD and sputtered a-IGZO, confirmed by x-ray photoelectron spectroscopy and bias-illumination-instability test measurements. Ultraviolet photoelectron spectroscopy analysis revealed a higher Fermi level (E F ) of the MOCVD a-IGZO (∼0.3 eV) film than that of the sputtered a-IGZO, which could be ascribed to the higher hydrogen concentration in the MOCVD a-IGZO film. Since the programming in a flash memory device is governed by the tunneling of electrons from the channel to charge trapping layer, the faster programming performance could be the result of a higher E F of MOCVD a-IGZO.

  9. In2Ga2ZnO7 oxide semiconductor based charge trap device for NAND flash memory

    NASA Astrophysics Data System (ADS)

    Hwang, Eun Suk; Kim, Jun Shik; Jeon, Seok Min; Lee, Seung Jun; Jang, Younjin; Cho, Deok-Yong; Hwang, Cheol Seong

    2018-04-01

    The programming characteristics of charge trap flash memory device adopting amorphous In2Ga2ZnO7 (a-IGZO) oxide semiconductors as channel layer were evaluated. Metal-organic chemical vapor deposition (MOCVD) and RF-sputtering processes were used to grow a 45 nm thick a-IGZO layer on a 20 nm thick SiO2 (blocking oxide)/p++-Si (control gate) substrate, where 3 nm thick atomic layer deposited Al2O3 (tunneling oxide) and 5 nm thick low-pressure CVD Si3N4 (charge trap) layers were intervened between the a-IGZO and substrate. Despite the identical stoichiometry and other physicochemical properties of the MOCVD and sputtered a-IGZO, a much faster programming speed of MOCVD a-IGZO was observed. A comparable amount of oxygen vacancies was found in both MOCVD and sputtered a-IGZO, confirmed by x-ray photoelectron spectroscopy and bias-illumination-instability test measurements. Ultraviolet photoelectron spectroscopy analysis revealed a higher Fermi level (E F) of the MOCVD a-IGZO (∼0.3 eV) film than that of the sputtered a-IGZO, which could be ascribed to the higher hydrogen concentration in the MOCVD a-IGZO film. Since the programming in a flash memory device is governed by the tunneling of electrons from the channel to charge trapping layer, the faster programming performance could be the result of a higher E F of MOCVD a-IGZO.

  10. Penetration experiments in aluminum 1100 targets using soda-lime glass projectiles

    NASA Technical Reports Server (NTRS)

    Horz, Friedrich; Cintala, Mark J.; Bernhard, Ronald P.; Cardenas, Frank; Davidson, William E.; Haynes, Gerald; See, Thomas H.; Winkler, Jerry L.

    1995-01-01

    The cratering and penetration behavior of annealed aluminum 1100 targets, with thickness varied from several centimeters to ultra-thin foils less than 1 micrometer thick, were experimentally investigated using 3.2 mm diameter spherical soda-lime glass projectiles at velocities from 1 to 7 km/s. The objective was to establish quantitative, dimensional relationships between initial impact conditions (impact velocity, projectile diameter, and target thickness) and the diameter of the resulting crater or penetration hole. Such dimensional relationships and calibration experiments are needed to extract the diameters and fluxes of hypervelocity particles from space-exposed surfaces and to predict the performance of certain collisional shields. The cratering behavior of aluminum 1100 is fairly well predicted. However, crater depth is modestly deeper for our silicate impactors than the canonical value based on aluminum projectiles and aluminum 6061-T6 targets. The ballistic-limit thickness was also different. These differences attest to the great sensitivity of detailed crater geometry and penetration behavior on the physical properties of both the target and impactor. Each penetration experiment was equipped with a witness plate to monitor the nature of the debris plume emanating from the rear of the target. This plume consists of both projectile fragments and target debris. Both penetration hole and witness-plate spray patterns systematically evolve in response to projectile diameter/target thickness. The relative dimensions of the projectile and target totally dominate the experimental products documented in this report; impact velocity is an important contributor as well to the evolution of penetration holes, but is of subordinate significance for the witness-plate spray patterns.

  11. New stimulation pattern design to improve P300-based matrix speller performance at high flash rate

    NASA Astrophysics Data System (ADS)

    Polprasert, Chantri; Kukieattikool, Pratana; Demeechai, Tanee; Ritcey, James A.; Siwamogsatham, Siwaruk

    2013-06-01

    Objective. We propose a new stimulation pattern design for the P300-based matrix speller aimed at increasing the minimum target-to-target interval (TTI). Approach. Inspired by the simplicity and strong performance of the conventional row-column (RC) stimulation, the proposed stimulation is obtained by modifying the RC stimulation through alternating row and column flashes which are selected based on the proposed design rules. The second flash of the double-flash components is then delayed for a number of flashing instants to increase the minimum TTI. The trade-off inherited in this approach is the reduced randomness within the stimulation pattern. Main results. We test the proposed stimulation pattern and compare its performance in terms of selection accuracy, raw and practical bit rates with the conventional RC flashing paradigm over several flash rates. By increasing the minimum TTI within the stimulation sequence, the proposed stimulation has more event-related potentials that can be identified compared to that of the conventional RC stimulations, as the flash rate increases. This leads to significant performance improvement in terms of the letter selection accuracy, the raw and practical bit rates over the conventional RC stimulation. Significance. These studies demonstrate that significant performance improvement over the RC stimulation is obtained without additional testing or training samples to compensate for low P300 amplitude at high flash rate. We show that our proposed stimulation is more robust to reduced signal strength due to the increased flash rate than the RC stimulation.

  12. Time-Space Position of Warm Dense Matter in Laser Plasma Interaction Process

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cao, L F; Uschmann, I; Forster, E

    2006-09-25

    Laser plasma interaction experiments have been perform performed using an fs Titanium Sapphire laser. Plasmas have been generated from planar PMMA targets using single laser pulses with 3.3 mJ pulse energy, 50 fs pulse duration at 800 nm wavelength. Electron density distributions of the plasmas in different delay times have been characterized by means of Nomarski Interferometry. Experimental data were cautiously compared with relevant 1D numerical simulation. Finally these results provide a first experience of searching for the time-space position of the so-called warm dense plasma in an ultra fast laser target interaction process. These experiments aim to prepare nearmore » solid-density plasmas for Thomson scattering experiments using the short wavelength free-electron laser FLASH, DESY Hamburg.« less

  13. Saccades to remembered targets: the effects of smooth pursuit and illusory stimulus motion

    NASA Technical Reports Server (NTRS)

    Zivotofsky, A. Z.; Rottach, K. G.; Averbuch-Heller, L.; Kori, A. A.; Thomas, C. W.; Dell'Osso, L. F.; Leigh, R. J.

    1996-01-01

    1. Measurements were made in four normal human subjects of the accuracy of saccades to remembered locations of targets that were flashed on a 20 x 30 deg random dot display that was either stationary or moving horizontally and sinusoidally at +/-9 deg at 0.3 Hz. During the interval between the target flash and the memory-guided saccade, the "memory period" (1.4 s), subjects either fixated a stationary spot or pursued a spot moving vertically sinusoidally at +/-9 deg at 0.3 Hz. 2. When saccades were made toward the location of targets previously flashed on a stationary background as subjects fixated the stationary spot, median saccadic error was 0.93 deg horizontally and 1.1 deg vertically. These errors were greater than for saccades to visible targets, which had median values of 0.59 deg horizontally and 0.60 deg vertically. 3. When targets were flashed as subjects smoothly pursued a spot that moved vertically across the stationary background, median saccadic error was 1.1 deg horizontally and 1.2 deg vertically, thus being of similar accuracy to when targets were flashed during fixation. In addition, the vertical component of the memory-guided saccade was much more closely correlated with the "spatial error" than with the "retinal error"; this indicated that, when programming the saccade, the brain had taken into account eye movements that occurred during the memory period. 4. When saccades were made to targets flashed during attempted fixation of a stationary spot on a horizontally moving background, a condition that produces a weak Duncker-type illusion of horizontal movement of the primary target, median saccadic error increased horizontally to 3.2 deg but was 1.1 deg vertically. 5. When targets were flashed as subjects smoothly pursued a spot that moved vertically on the horizontally moving background, a condition that induces a strong illusion of diagonal target motion, median saccadic error was 4.0 deg horizontally and 1.5 deg vertically; thus the horizontal error was greater than under any other experimental condition. 6. In most trials, the initial saccade to the remembered target was followed by additional saccades while the subject was still in darkness. These secondary saccades, which were executed in the absence of visual feedback, brought the eye closer to the target location. During paradigms involving horizontal background movement, these corrections were more prominent horizontally than vertically. 7. Further measurements were made in two subjects to determine whether inaccuracy of memory-guided saccades, in the horizontal plane, was due to mislocalization at the time that the target flashed, misrepresentation of the trajectory of the pursuit eye movement during the memory period, or both. 8. The magnitude of the saccadic error, both with and without corrections made in darkness, was mislocalized by approximately 30% of the displacement of the background at the time that the target flashed. The magnitude of the saccadic error also was influenced by net movement of the background during the memory period, corresponding to approximately 25% of net background movement for the initial saccade and approximately 13% for the final eye position achieved in darkness. 9. We formulated simple linear models to test specific hypotheses about which combinations of signals best describe the observed saccadic amplitudes. We tested the possibilities that the brain made an accurate memory of target location and a reliable representation of the eye movement during the memory period, or that one or both of these was corrupted by the illusory visual stimulus. Our data were best accounted for by a model in which both the working memory of target location and the internal representation of the horizontal eye movements were corrupted by the illusory visual stimulus. We conclude that extraretinal signals played only a minor role, in comparison with visual estimates of the direction of gaze, in planning eye movements to remembered targ.

  14. Electron Acceleration from the Interaction of VULCAN 100TW Laser with Au Foils and its Dependence on Laser Polarisation

    NASA Astrophysics Data System (ADS)

    Nagel, S. R.; Bellei, C.; Kneip, S.; Mangles, S. P. D.; Palmer, C.; Willingale, L.; Dangor, A. E.; Najmudin, Z.; Clarke, R. J.; Heathcote, R.; Henig, A.; Schreiber, J.; Saevert, A.; Kaluza, M.

    2008-11-01

    Electrons as well as ions can be accelerated to high energies (MeV) by high intensity laser interactions with solid targets. An overview of an experiment on the Vulcan laser (pulse length cτ˜150μm, energy on target ˜60 J), will be presented. In this experiment electron acceleration from thick overdense plasmas is investigated by conducting thickness scans using Au foil targets ranging from 10 to 100 μm. The electron spectra, of the most energetic electrons produced in the interaction, are measured along the laser direction and extend up to 40MeV. Surprisingly the electron acceleration depends on target thickness. Simultaneously rear surface proton beam profiles show a dependence of target thickness. Both effects are attributed to electron recirculation. In addition the effects of polarisation was investigated. A decrease in number and effective temperature of energetic electrons is observed for circular polarisation as compared to linear polarisation.

  15. Phototoxic effects of commercial photographic flash lamp on rat eyes.

    PubMed

    Inoue, Makoto; Shinoda, Kei; Ohde, Hisao; Tezuka, Keiji; Hida, Tetsuo

    2006-11-01

    To determine whether exposure of the cornea and retina of rats to flashes from a commercial photographic flash lamp is phototoxic. Sprague-Dawley rats were exposed to 10, 100, or 1,000 flashes of the OPTICAM 16M photographic flash lamp (Fujikoeki, Japan) placed 0.1, 1, or 3 m from the eyes. Corneal damage was assessed by a fluorescein staining score, and the retinal damage by eletroretinography (ERG) and histology before and 24 h after exposure. Exposure of the eyes to 1,000 flashes at 0.1 m increased the fluorescein staining score significantly (P = 0.009, the Mann-Whitney test). Scanning electron microscopy (SEM) of the cornea showed a detachment of the epithelial cells from the surface after this exposure. The amplitude of the a-wave was decreased significantly by 23.0% (P = 0.026) of the amplitude before the exposure, and the b-wave by 19.7% (P = 0.0478) following 1,000 flashes at 0.1 m but not by the other exposures. TUNEL-positive cells were present in the outer nuclear layer only after the extreme exposure, but no significant decrease in retinal thickness was seen under any condition. The fluorescein staining score and ERGs recovered to control levels within 1 week. Light exposure to a photographic flash lamp does not induce damage to the cornea and retina except when they are exposed to 1,000 flashes at 0.1 m.

  16. Digital analysis of wind tunnel imagery to measure fluid thickness

    NASA Technical Reports Server (NTRS)

    Easton, Roger L., Jr.; Enge, James

    1992-01-01

    Documented here are the procedure and results obtained from the application of digital image processing techniques to the problem of measuring the thickness of a deicing fluid on a model airfoil during simulated takeoffs. The fluid contained a fluorescent dye and the images were recorded under flash illumination on photographic film. The films were digitized and analyzed on a personal computer to obtain maps of the fluid thickness.

  17. DYNAMIC PROPERTIES OF SHOCK LOADED THIN URANIUM FOILS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Robbins, D. L.; Kelly, A. M.; Alexander, D. J.

    A series of spall experiments has been completed with thin depleted uranium targets, nominally 0.1 mm thick. The first set of uranium spall targets was cut and ground to final thickness from electro-refined, high-purity, cast uranium. The second set was rolled to final thickness from low purity uranium. The impactors for these experiments were laser-launched 0.05-mm thick copper flyers, 3 mm in diameter. Laser energies were varied to yield a range of flyer impact velocities. This resulted in varying degrees of damage to the uranium spall targets, from deformation to complete spall or separation at the higher velocities. Dynamic measurementsmore » of the uranium target free surface velocities were obtained with dual velocity interferometers. Uranium targets were recovered and sectioned after testing. Free surface velocity profiles were similar for the two types of uranium, but spall strengths (estimated from the magnitude of the pull-back signal) are higher for the high-purity cast uranium. Velocity profiles and microstructural evidence of spall from the sectioned uranium targets are presented.« less

  18. High-energy photon spectra from a coaxial gas-puff experiment

    NASA Astrophysics Data System (ADS)

    Warren, S. W. R.; Degnan, J. H.; Beason, C. W.; Price, D. W.; Snell, M. P.

    1987-04-01

    An array of plastic scintillator/photomultiplier detectors was used to determine the high-energy (h x nu greater than 35 keV) photon spectra of a 130-kJ, 60-kV gas-injected coaxial-gun experiment. The detector array used six different filter-material/thickness combinations. High-energy photon signals were readily observed. The spectra were determined by deconvolution. The spectra have three characteristic components: radiative emission from high-Z impurities in the plasma, beam-target excited line emission, and thick-target bremsstrahlung from an electron beam generated in the plasma column. The electron beam consistent with the thick-target bremsstrahlung assumption was of the order of 100 A above 10 keV.

  19. Overlay degradation induced by film stress

    NASA Astrophysics Data System (ADS)

    Huang, Chi-hao; Liu, Yu-Lin; Luo, Shing-Ann; Yang, Mars; Yang, Elvis; Hung, Yung-Tai; Luoh, Tuung; Yang, T. H.; Chen, K. C.

    2017-03-01

    The semiconductor industry has continually sought the approaches to produce memory devices with increased memory cells per memory die. One way to meet the increasing storage capacity demand and reduce bit cost of NAND flash memories is 3D stacked flash cell array. In constructing 3D NAND flash memories, increasing the number of stacked layers to build more memory cell number per unit area necessitates many high-aspect-ratio etching processes accordingly the incorporation of thick and unique etching hard-mask scheme has been indispensable. However, the ever increasingly thick requirement on etching hard-mask has made the hard-mask film stress control extremely important for maintaining good process qualities. The residual film stress alters the wafer shape consequently several process impacts have been readily observed across wafer, such as wafer chucking error on scanner, film peeling, materials coating and baking defects, critical dimension (CD) non-uniformity and overlay degradation. This work investigates the overlay and residual order performance indicator (ROPI) degradation coupling with increasingly thick advanced patterning film (APF) etching hard-mask. Various APF films deposited by plasma enhanced chemical vapor deposition (PECVD) method under different deposition temperatures, chemicals combinations, radio frequency powers and chamber pressures were carried out. And -342MPa to +80MPa film stress with different film thicknesses were generated for the overlay performance study. The results revealed the overlay degradation doesn't directly correlate with convex or concave wafer shapes but the magnitude of residual APF film stress, while increasing the APF thickness will worsen the overlay performance and ROPI strongly. High-stress APF film was also observed to enhance the scanner chucking difference and lead to more serious wafer to wafer overlay variation. To reduce the overlay degradation from ever increasingly thick APF etching hard-mask, optimizing the film stress of APF is the most effective way and high order overlay compensation is also helpful.

  20. M and D SIG progress report: Laboratory simulations of LDEF impact features

    NASA Technical Reports Server (NTRS)

    Horz, Friedrich; Bernhard, R. P.; See, T. H.; Atkinson, D.; Allbrooks, M.

    1992-01-01

    Laboratory impact experiments are needed to understand the relationship between a measured penetration hole diameter and associated projectile dimension in the thermal blankets of experiment A0178, which occupied some 16 sq. m. These blankets are composed of 125 micron thick Teflon that has an Ag/enconel second mirror surface, backed by organic binder and Chemglaze paint for a total thickness of some 170 microns. While dedicated experiments are required to understand the penetration behavior of this compound target in detail, we report here on impact simulations sponsored by other projects into pure Teflon and aluminum targets. These experiments will allow first order interpretations of impact features on the Long Duration Exposure Facility (LDEF), and they will serve as guides for dedicated experiments that employ the real LDEF blankets, both exposed and unexposed, for a refined understanding of the LDEF's collisional environment. We employed a light gas gun to launch soda-lime glass spheres from 50 to 3200 microns in diameter that impacted targets of variable thickness. Penetration measurements are given.

  1. Compact and reliable triggering method for near muzzle flash radiography

    NASA Astrophysics Data System (ADS)

    Lee, Eun S.; Hwang, Eul H.; Yim, Dong W.; Song, So Y.

    1993-01-01

    Precise timing for x-ray bursts is crucial in acquiring useful information from flash radiographic experiments. Triggering the flash x-ray system near the muzzle is a difficult task because of the intrinsic nature of the muzzle blast. In this work a compact and reliable triggering method for near muzzle flash radiography is introduced; a piezoelectric pin probe attached at the end of the barrel. These types of probes have not been activated by the precursor shock wave, but they have been activated by the main blast wave only. Reliability in triggering the flash x-ray system has been confirmed throughout a series of flash radiographic experiments near the muzzle for gun barrels with calibers up to 105 mm.

  2. SUMO regulates proteasome-dependent degradation of FLASH/Casp8AP2

    PubMed Central

    Vennemann, Astrid; Hofmann, Thomas G.

    2013-01-01

    FLASH/Casp8AP2 is a huge multifunctional protein involved in multiple cellular processes, reaching from death receptor signaling to regulation of histone gene transcription and histone mRNA processing. Previous work has shown that FLASH localizes to Cajal bodies and promyelocytic leukemia (PML) bodies. However, the function of its nuclear body association remains unclear. Here we demonstrate that murine FLASH is covalently modified by SUMO at Lys residue 1792. Interestingly, ectopic expression of SUMO results in proteasome-dependent degradation of FLASH. A point mutant of FLASH with a mutated SUMO acceptor lysine residue, FLASHK1792R, is resistant to SUMO-induced degradation. Finally, we show that arsenic trioxide, a drug known to potentiate SUMO modification and degradation of PML, triggers recruitment of FLASH to PML bodies and concomitant loss of FLASH protein. Our data suggest that SUMO targets FLASH for proteasome-dependent degradation, which is associated with recruitment of FLASH to PML bodies. PMID:23673342

  3. Studies of Ion Acceleration from Thin Solid-Density Targets on High-Intensity Lasers

    NASA Astrophysics Data System (ADS)

    Willis, Christopher R.

    Over the past two decades, a number of experiments have been performed demonstrating the acceleration of ions from the interaction of an intense laser pulse with a thin, solid density target. These ions are accelerated by quasi-static electric fields generated by energetic electrons produced at the front of the target, resulting in ion energies up to tens of MeV. These ions have been widely studied for a variety of potential applications ranging from treatment of cancer to the production of neutrons for advanced radiography techniques. However, realization of these applications will require further optimization of the maximum energy, spectrum, or species of the accelerated ions, which has been a primary focus of research to date. This thesis presents two experiments designed to optimize several characteristics of the accelerated ion beam. The first of these experiments took place on the GHOST laser system at the University of Texas at Austin, and was designed to demonstrate reliable acceleration of deuterium ions, as needed for the most efficient methods of neutron generation from accelerated ions. This experiment leveraged cryogenically cooled targets coated in D2 O ice to suppress the protons which typically dominate the accelerated ions, producing as many as 2 x 1010 deuterium ions per 1 J laser shot, exceeding the proton yield by an average ratio of 5:1. The second major experiment in this work was performed on the Scarlet laser system at The Ohio State University, and studied the accelerated ion energy, yield, and spatial distribution as a function of the target thickness. In principle, the peak energy increases with decreasing target thickness, with the thinnest targets accessing additional acceleration mechanisms which provide favorable scaling with the laser intensity. However, laser prepulse characteristics provide a lower bound for the target thickness, yielding an optimum target thickness for ion acceleration which is dependent on the laser system. This experiment utilized new liquid crystal film targets developed at OSU, which may be formed at variable thicknesses from tens of nanometers to several microns. On this experiment, an optimum ion energy and flux was reached for targets of 600-900 nm, providing a peak proton energy of 24 MeV, and total ion flux of > 109 protons over 3.4 MeV from 5.5 J of laser energy at an intensity of 1 x 1020 W cm -2. The primary ion diagnostics for these two experiments are described in detail, including the analysis techniques needed to extract absolutely calibrated spatial and spectral distributions of the accelerated ions. Additionally, a new technique for target alignment is presented, providing repeatable target alignment on the micron scale. This allows for a repeatable laser intensity on target, allowing improved shot to shot consistency on high intensity experiments. In addition to these two experiments, work on the upgrade and characterization of the 400 TW Scarlet laser is discussed, including several calculations critical to the design and upgrade of the laser system, as well as prepulse characterization needed for experiments on thin targets.

  4. Antipodal fragment velocities for porous and weak targets at catastrophic impacts

    NASA Technical Reports Server (NTRS)

    Yanagisawa, M.; Itoi, T.

    1993-01-01

    Mortar, porous alumina, and sand targets, which were spherical in shape and from 11 to 15 cm in diameter, were impacted normally by plastic (polycarbonate) projectiles of nearly 1 g in mass at velocities about 6 km/s. Fragment velocity at the antipole of impact site (antipodal velocity, V(sub a)), for each experiment, was obtained from two Flash X-ray images recorded prior to and at predetermined delayed time after impact event. It has been revealed that the velocities for the same E/M(sub t) (impact energy divided by target mass) depend strongly on target material, and differ about an order of magnitude between the sand and basalt.

  5. Antipodal fragment velocities for porous and weak targets at catastrophic impacts

    NASA Astrophysics Data System (ADS)

    Yanagisawa, M.; Itoi, T.

    1993-03-01

    Mortar, porous alumina, and sand targets, which were spherical in shape and from 11 to 15 cm in diameter, were impacted normally by plastic (polycarbonate) projectiles of nearly 1 g in mass at velocities about 6 km/s. Fragment velocity at the antipole of impact site (antipodal velocity, V(sub a)), for each experiment, was obtained from two Flash X-ray images recorded prior to and at predetermined delayed time after impact event. It has been revealed that the velocities for the same E/M(sub t) (impact energy divided by target mass) depend strongly on target material, and differ about an order of magnitude between the sand and basalt.

  6. Design and evaluation of web-based image transmission and display with different protocols

    NASA Astrophysics Data System (ADS)

    Tan, Bin; Chen, Kuangyi; Zheng, Xichuan; Zhang, Jianguo

    2011-03-01

    There are many Web-based image accessing technologies used in medical imaging area, such as component-based (ActiveX Control) thick client Web display, Zerofootprint thin client Web viewer (or called server side processing Web viewer), Flash Rich Internet Application(RIA) ,or HTML5 based Web display. Different Web display methods have different peformance in different network environment. In this presenation, we give an evaluation on two developed Web based image display systems. The first one is used for thin client Web display. It works between a PACS Web server with WADO interface and thin client. The PACS Web server provides JPEG format images to HTML pages. The second one is for thick client Web display. It works between a PACS Web server with WADO interface and thick client running in browsers containing ActiveX control, Flash RIA program or HTML5 scripts. The PACS Web server provides native DICOM format images or JPIP stream for theses clients.

  7. Differentiation of debris-flow and flash-flood deposits: implications for paleoflood investigations

    USGS Publications Warehouse

    Waythomas, Christopher F.; Jarrett, Robert D.; ,

    1993-01-01

    Debris flows and flash floods are common geomorphic processes in the Colorado Rocky Mountain Front Range and foothills. Usually, debris flows and flash floods are associated with excess summer rainfall or snowmelt, in areas were unconsolidated surficial deposits are relatively thick and slopes are steep. In the Front Range and foothills, flash flooding is limited to areas below about 2300m whereas, debris flow activity is common throughout the foothill and alpine zones and is not necessarily elevation limited. Because flash floods and debris flows transport large quantities of bouldery sediment, the resulting deposits appear somewhat similar even though such deposits were produced by different processes. Discharge estimates based on debris-flow deposits interpreted as flash-flood deposits have large errors because techniques for discharge retrodiction were developed for water floods with negligible sediment concentrations. Criteria for differentiating between debris-flow and flash-flood deposits are most useful for deposits that are fresh and well-exposed. However, with the passage of time, both debris-flow and flash-flood deposits become modified by the combined effects of weathering, colluviation, changes in surface morphology, and in some instances removal of interstitial sediment. As a result, some of the physical characteristics of the deposits become more alike. Criteria especially applicable to older deposits are needed. We differentiate flash-flood from debris-flow and other deposits using clast fabric measurements and other morphologic and sedimentologic techniques (e.g., deposit morphology, clast lithology, particle size and shape, geomorphic setting).

  8. Study of meteoroid impact craters on various materials (AO 138-1). Attempt at dust debris collection with stacked detectors (AO 138-2)

    NASA Technical Reports Server (NTRS)

    Mandeville, Jean Claude

    1991-01-01

    Part of the Long Duration Exposure Facility (LDEF) tray allocated to French experiments, known as FRECOPA payload, was devoted to the study of dust particles. Two passive experiments were flown: one composed of a set of glass and metallic samples and one composed of multilayer thin foils detectors. In addition to these experiments, a broad variety of materials were exposed to the bombardment of microparticles and provide more data. Thick target experiment comprises selected metallic (Al, Au, Cu, W, Stainless Steel) 250 microns thick and glass surfaces 1.5 mm thick. Crater size distribution from these thick target experiments enable, with the aid of lab calibrations by solid particle accelerators, the evaluation of the incident microparticle flux in the near earth environment. The aim of the multiple foil penetration and collection experiment is primarily to study the feasibility of multilayer thin film detectors acting as energy sorters in order to collect micrometeoroids, if not in their original shape, at least as 'breakup' fragments suitable for chemical analysis. Foil thicknesses range from 0.75 to 5 microns of Al.

  9. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kwan, T.J.T.; Moir, D.C.; Snell, C.M.

    In high resolution flash x-ray imaging technology the electric field developed between the electron beam and the converter target is large enough to draw ions from the target surface. The ions provide fractional neutralization and cause the electron beam to focus radially inward, and the focal point subsequently moves upstream due to the expansion of the ion column. A self-bias target concept is proposed and verified via computer simulation that the electron charge deposited on the target can generate an electric potential, which can effectively limit the ion motion and thereby stabilize the growth of the spot size. A targetmore » chamber using the self bias target concept was designed and tested in the Integrated Test Stand (ITS). The authors have obtained good agreement between computer simulation and experiment.« less

  10. Flash Floods Simulation Using a Physical based hydrological Model at the Eastern Nile Basin: Case studies; Wadi Assiut, Egypt and Wadi Gumara, Lake Tana, Ethiopia.

    NASA Astrophysics Data System (ADS)

    Saber, M.; Sefelnasr, A.; Yilmaz, K. K.

    2015-12-01

    Flash flood is a natural hydrological phenomenon which affects many regions of the world. The behavior and effect of this phenomenon is different from one region to the other regions depending on several issues such as climatology and hydrological and topographical conditions at the target regions. Wadi assiut, Egypt as arid environment, and Gumara catchment, Lake Tana, Ethiopia, as humid conditions have been selected for application. The main target of this work is to simulate flash floods at both catchments considering the difference between them on the flash flood behaviors based on the variability of both of them. In order to simulate the flash floods, remote sensing data and a physical-based distributed hydrological model, Hydro-BEAM-WaS (Hydrological River Basin Environmental Assessment Model incorporating Wadi System) have been integrated used in this work. Based on the simulation results of flash floods in these regions, it was found that the time to reach the maximum peak is very short and consequently the warning time is very short as well. It was found that the flash floods starts from zero flow in arid environment, but on the contrary in humid arid, it starts from Base flow which is changeable based on the simulated events. Distribution maps of flash floods showing the vulnerable regions of these selected areas have been developed. Consequently, some mitigation strategies relying on this study have been introduced. The proposed methodology can be applied effectively for flash flood forecasting at different climate regions, however the paucity of observational data.

  11. Beam Research Program

    DTIC Science & Technology

    1984-04-01

    wavelengths. A direct application of such a laser is isotope separation. 2. For a brief status report of the Laboratory’s high- explosive flash...operation in the fall of 1982. in a 50-MeV Advanced Test Accelerator Facility (the ATA)1 that we are con- structing at our high- explosives test loca...chemical explosives in target-damage studies. Potential hazards associated with the ATA experiments were considered in choosing our site. LLNL’s

  12. Dual-band infrared imaging for quantitative corrosion detection in aging aircraft

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Del Grande, N.K.

    1993-12-31

    Aircraft skin thickness-loss from corrosion has been measured using dual-band infrared (DBIR) imaging on a flash-heated Boeing 737 fuselage structure. The authors mapped surface temperature differences of 0.2 to 0.6 C for 5 to 14 % thickness losses within corroded lap splices at 0.4 seconds after the heat flash. The procedure mapped surface temperature differences at sites without surface-emissivity clutter (from dirt, dents, tape, markings, ink, sealants, uneven paint, paint stripper, exposed metal and roughness variations). They established the correlation of percent thickness loss with surface temperature rise using a partially corroded F-18 wing box and several aluminum panels whichmore » had thickness losses from milled flat-bottom holes. The authors mapped the lap splice composite thermal inertia, (k{rho}c){sup 1/2}, which characterized shallow skin defects within the lap splice at early times (<0.3 s) and deeper skin defects within the lap splice at late times (>0.4 s). Corrosion invaded the inside of the Boeing 737 lap splice, beneath the galley and the latrine, where they observed ``pillowing`` from volume build-up of corrosion by-products.« less

  13. Dual-band infrared (DBIR) imaging inspections of Boeing 737 and KC-135 aircraft panels

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Del Grande, N.K.; Dolan, K.W.; Durbin, P.F.

    1993-08-27

    We apply dual-band infrared (DBIR) imaging as a dynamic thermal tomography tool for wide area inspection of a Boeing 737 aircraft, and several Boeing KC-135 aircraft panels. Our analyses are discussed in this report. After flash-heating the aircraft skin, we record synchronized DBIR images every 40 ms, from onset to 8 seconds after the heat flash. We analyze selective DBIR image ratios which enhance surface temperature contrast and remove surface-emissivity clutter (from dirt, dents, tape, markings, ink, sealants, uneven paint, paint stripper, exposed metal and roughness variations). The Boeing 737 and KC-135 aircraft fuselage panels have varying percent thickness lossesmore » from corrosion. We established the correlation of percent thickness loss with surface temperature rise (above ambient) for a partially corroded F-18 wing box structure and several aluminum reference panels. Based on this correlation, lap splice temperatures rise 1{degrees}C per 24 {plus_minus} 5 % material loss at 0.4 s after the heat flash. We show tables, charts and temperature maps of typical lap splice material losses for the riveted (and bonded) Boeing 737, and the riveted (but unbonded) Boeing KC-135. We map the fuselage composite thermal inertia, based on the (inverse) slope of the surface temperature versus inverse square root of time. Composite thermal inertia maps characterize shallow skin defects within the lap splice at early times (<0.3 s) and deeper skin defects within the lap splice at late times (>0.4 s). Late time composite thermal inertia maps depict where corrosion-related thickness losses occur. Lap splice sites on a typical Boeing KC-135 panel with low composite thermal inertia values had high skin-thickness losses from corrosion.« less

  14. Evaluation of intervertebral disc cartilaginous endplate structure using magnetic resonance imaging.

    PubMed

    Moon, Sung M; Yoder, Jonathon H; Wright, Alexander C; Smith, Lachlan J; Vresilovic, Edward J; Elliott, Dawn M

    2013-08-01

    The cartilaginous endplate (CEP) is a thin layer of hyaline cartilage positioned between the vertebral endplate and nucleus pulposus (NP) that functions both as a mechanical barrier and as a gateway for nutrient transport into the disc. Despite its critical role in disc nutrition and degeneration, the morphology of the CEP has not been well characterized. The objective of this study was to visualize and report observations of the CEP three-dimensional morphology, and quantify CEP thickness using an MRI FLASH (fast low-angle shot) pulse sequence. MR imaging of ex vivo human cadaveric lumbar spine segments (N = 17) was performed in a 7T MRI scanner with sequence parameters that were selected by utilizing high-resolution T1 mapping, and an analytical MRI signal model to optimize image contrast between CEP and NP. The CEP thickness at five locations along the mid-sagittal AP direction (center, 5 mm, 10 mm off-center towards anterior and posterior) was measured, and analyzed using two-way ANOVA and a post hoc Bonferonni test. For further investigation, six in vivo volunteers were imaged with a similar sequence in a 3T MRI scanner. In addition, decalcified and undecalcified histology was performed, which confirmed that the FLASH sequence successfully detected the CEP. CEP thickness determined by MRI in the mid-sagittal plane across all lumbar disc levels and locations was 0.77 ± 0.24 mm ex vivo. The CEP thickness was not different across disc levels, but was thinner toward the center of the disc. This study demonstrates the potential of MRI FLASH imaging for structural quantification of the CEP geometry, which may be developed as a technique to evaluate changes in the CEP with disc degeneration in future applications.

  15. Proton Energy Optimization and Spatial Distribution Analysis from a Thickness Study Using Liquid Crystal Targets

    NASA Astrophysics Data System (ADS)

    Willis, Christopher; Poole, Patrick; Schumacher, Douglas; Freeman, Richard; van Woerkom, Linn

    2016-10-01

    Laser-accelerated ions from thin targets have been widely studied for applications including secondary radiation sources and cancer therapy, with recent studies trending towards thinner targets which can provide improved ion energies and yields. Here we discuss results from an experiment on the Scarlet laser at OSU using variable thickness liquid crystal targets. On this experiment, the spatial and spectral distributions of accelerated ions were measured along target normal and laser axes at varying thicknesses from 150nm to 2000nm at a laser intensity of 1 ×1020W /cm2 . Maximum ion energy was observed for targets in the 600 - 800nm thickness range, with proton energies reaching 24MeV . The ions were further characterized using radiochromic film, revealing an unusual spatial distribution on many laser shots. Here, the peak ion yield falls in an annular ring surrounding the target normal, with an increasing divergence angle as a function of ion energy. Details of these spatial and spectral ion distributions will be presented, including spectral deconvolution of the RCF data, revealing additional trends in the accelerated ion distributions. Supported by the DARPA PULSE program through a Grant from AMRDEC, and by the NNSA under contract DE-NA0001976.

  16. An investigation of life circumstances associated with the experience of hot flashes in Campeche, Mexico.

    PubMed

    Huicochea-Gómez, Laura; Sievert, Lynnette Leidy; Cahuich-Campos, Diana; Brown, Daniel E

    2017-01-01

    The purpose of this study was to better understand the experience of calores (hot flashes) in the state of Campeche, Mexico, and characteristics of women's lives. This study was carried out to understand the sociocultural context of women's lives before conducting a larger semistructured survey in the same communities. Eighty-five women from rural and urban settings participated in open-ended interviews about the menopausal transition, with particular attention to hot flashes. Univariate and logistic regression analyses identified potential determinants of hot flashes. Qualitative responses were analyzed for central themes from the 40 women who experienced "calores" associated with menopause at the time of interview. The word "calores" was used to describe a variety of sensations and experiences related to the hot climate, infections, going in and out of air-conditioning, emotional stress, and physical exertion, as well as the symptom associated with menopause. In quantitative analyses, the likelihood of experiencing hot flashes varied by menopause status and rural/urban residence. In qualitative analyses, themes that characterized the lives of women with hot flashes were as follows: the search for, and the availability of, biomedical care; presence or absence of networks of social support; marital status and quality of the relationship; and occupational stress. Hot flash questionnaires can elicit different symptom frequencies depending on the language used and the sociocultural context of women's lives. Qualitative findings suggest that the themes most likely to influence the perception and experience of hot flashes in Campeche are biomedicine, social support, marriage, and stress.

  17. GROWING WHITE DWARFS TO THE CHANDRASEKHAR LIMIT: THE PARAMETER SPACE OF THE SINGLE DEGENERATE SN Ia CHANNEL

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hillman, Y.; Prialnik, D.; Kovetz, A.

    Can a white dwarf (WD), accreting hydrogen-rich matter from a non-degenerate companion star, ever exceed the Chandrasekhar mass and explode as a SN Ia? We explore the range of accretion rates that allow a WD to secularly grow in mass, and derive limits on the accretion rate and on the initial mass that will allow it to reach 1.4M{sub ⊙}—the Chandrasekhar mass. We follow the evolution through a long series of hydrogen flashes, during which a thick helium shell accumulates. This determines the effective helium mass accretion rate for long-term, self-consistent evolutionary runs with helium flashes. We find that netmore » mass accumulation always occurs despite helium flashes. Although the amount of mass lost during the first few helium shell flashes is a significant fraction of that accumulated prior to the flash, that fraction decreases with repeated helium shell flashes. Eventually no mass is ejected at all during subsequent flashes. This unexpected result occurs because of continual heating of the WD interior by the helium shell flashes near its surface. The effect of heating is to lower the electron degeneracy throughout the WD, especially in the outer layers. This key result yields helium burning that is quasi-steady state, instead of explosive. We thus find a remarkably large parameter space within which long-term, self-consistent simulations show that a WD can grow in mass and reach the Chandrasekhar limit, despite its helium flashes.« less

  18. Fluid Physics

    NASA Image and Video Library

    2001-05-31

    Whipped cream and the filling for pumpkin pie are two familiar materials that exhibit the shear-thinning effect seen in a range of industrial applications. It is thick enough to stand on its own atop a piece of pie, yet flows readily when pushed through a tube. This demonstrates the shear-thinning effect that was studied with the Critical Viscosity of Xenon Experiment (CVX-2) on the STS-107 Research 1 mission in 2002. CVX observed the behavior of xenon, a heavy inert gas used in flash lamps and ion rocket engines, at its critical point. The principal investigator was Dr. Robert Berg of the National Institutes of Standards and Technology in Gaithersburg, MD.

  19. Thick-target transmission method for excitation functions of interaction cross sections

    NASA Astrophysics Data System (ADS)

    Aikawa, M.; Ebata, S.; Imai, S.

    2016-09-01

    We propose a method, called as thick-target transmission (T3) method, to obtain an excitation function of interaction cross sections. In an ordinal experiment to measure the excitation function of interaction cross sections by the transmission method, we need to change the beam energy for each cross section. In the T3 method, the excitation function is derived from the beam attenuations measured at the targets of different thicknesses without changing the beam energy. The advantage of the T3 method is the simplicity and availability for radioactive beams. To confirm the availability, we perform a simulation for the 12C + 27Al system with the PHITS code instead of actual experiments. Our results have large uncertainties but well reproduce the tendency of the experimental data.

  20. The scotopic electroretinogram of the sugar glider related to histological features of its retina.

    PubMed

    Akula, James D; Esdaille, Tricia M; Caffé, A Romeo; Naarendorp, Franklin

    2011-11-01

    The flash electroretinogram (ERG) was used to characterize the scotopic retinal function in a marsupial. Key parameter values of the a- and b-waves of adult male sugar gliders, Petaurus breviceps breviceps, elicited with ganzfeld flashes were determined under dark- and light-adapted conditions. Using standard histological methods, the thicknesses of the major layers of the retina were assessed to provide insight into the nature of the ERG responses. The ERG and histological results were compared to corresponding data for placental C57Bl/6 mice to establish whether the functional retinal specialization that underlies scotopic visual function in a marsupial parallels that of a placental mouse. The sensitivity of the a-wave assessed with the Lamb and Pugh (Invest Ophthalmol Vis Sci 47:5138-5152, 2006) "model" and that of the b-wave assessed with standard methods were lower in the sugar glider compared to the mouse. The thickness of the sugar glider retina was two-third of that of the mouse. The high-intensity flash ERG of the sugar glider substantially differed in shape from that of the mouse reflecting perhaps structural and functional differences between the two species at the level of the inner retina.

  1. Mossbauer studies of bulk and thin-film FeTe

    NASA Technical Reports Server (NTRS)

    Aggarwal, K.; Escue, W. T.; Mendiratta, R. G.

    1978-01-01

    In study, dependence of Mossbauer parameters on film thickness and film substrate was measured and related to iron tellurium structure. Report also describes film deposition technique (flash deposition) and Mossbauer apparatus.

  2. Flash radiography with 24 GeV/c protons

    NASA Astrophysics Data System (ADS)

    Morris, C. L.; Ables, E.; Alrick, K. R.; Aufderheide, M. B.; Barnes, P. D.; Buescher, K. L.; Cagliostro, D. J.; Clark, D. A.; Clark, D. J.; Espinoza, C. J.; Ferm, E. N.; Gallegos, R. A.; Gardner, S. D.; Gomez, J. J.; Greene, G. A.; Hanson, A.; Hartouni, E. P.; Hogan, G. E.; King, N. S. P.; Kwiatkowski, K.; Liljestrand, R. P.; Mariam, F. G.; Merrill, F. E.; Morgan, D. V.; Morley, K. B.; Mottershead, C. T.; Murray, M. M.; Pazuchanics, P. D.; Pearson, J. E.; Sarracino, J. S.; Saunders, A.; Scaduto, J.; Schach von Wittenau, A. E.; Soltz, R. A.; Sterbenz, S.; Thompson, R. T.; Vixie, K.; Wilke, M. D.; Wright, D. M.; Zumbro, J. D.

    2011-05-01

    The accuracy of density measurements and position resolution in flash (40 ns) radiography of thick objects with 24 Gev/c protons is investigated. A global model fit to step wedge data is shown to give a good description spanning the periodic table. The parameters obtained from the step wedge data are used to predict transmission through the French Test Object (FTO), a test object of nested spheres, to a precision better than 1%. Multiple trials have been used to show that the systematic errors are less than 2%. Absolute agreement between the average radiographic measurements of the density and the known density is 1%. Spatial resolution has been measured to be 200 μm at the center of the FTO. These data verify expectations of the benefits provided by high energy hadron radiography for thick objects.

  3. Phase transformation in the alumina-titania system during flash sintering experiments

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jha, S. K.; Lebrun, J. M.; Raj, R.

    2016-02-01

    We show that phase transformation in the alumina–titania system, which produces aluminum-titanate, follows an unusual trajectory during flash sintering. The experiments begin with mixed powders of alumina–titania and end in dense microstructures that are transformed into aluminum-titanate. The sintering and the phase transformation are separated in time, with the sintering occurs during Stage II, and phase transformation during Stage III of the flash sintering experiment. Stage III is the steady-state condition of flash activated state that is established under current control, while Stage II is the period of transition from voltage to current control. The extent of phase transformation increasesmore » with the current density and the hold time in Stage III.« less

  4. Measurement of O and Ti atom displacements in TiO 2 during flash sintering experiments

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yoon, Bola; Yadav, Devinder; Raj, Rishi

    In-situ flash experiments on rutile TiO 2 were performed at the synchrotron at the Brookhaven National Laboratory. Pair distribution function analysis of total X-ray scattering measurements yielded mean-square atomic displacements of oxygen and titanium atoms during the progression of the 3 stages of flash. The displacements are measured to be far greater for oxygen atoms than for titanium atoms. Thus, these large displacements may signal an “elastic softening” of the lattice, which, recently, has been predicted as a precursor to the onset of flash.

  5. Measurement of O and Ti atom displacements in TiO 2 during flash sintering experiments

    DOE PAGES

    Yoon, Bola; Yadav, Devinder; Raj, Rishi; ...

    2017-12-29

    In-situ flash experiments on rutile TiO 2 were performed at the synchrotron at the Brookhaven National Laboratory. Pair distribution function analysis of total X-ray scattering measurements yielded mean-square atomic displacements of oxygen and titanium atoms during the progression of the 3 stages of flash. The displacements are measured to be far greater for oxygen atoms than for titanium atoms. Thus, these large displacements may signal an “elastic softening” of the lattice, which, recently, has been predicted as a precursor to the onset of flash.

  6. Muzzle flash issues related to the Waco FLIR analysis

    NASA Astrophysics Data System (ADS)

    Grant, Barbara G.; Hardy, David T.

    2001-09-01

    The controversy surrounding the origin of flashes on the Mt. Carmel FLIR videotape acquired on April 19, 1993, is introduced. The characteristics of muzzle flash are reviewed. A comparative weapons description is offered. The temporal, spatial, and radiance characteristics of thermal infrared muzzle flash are addressed. Data acquired from a field experiment are presented. The authors conclude that the spatial characteristics of muzzle flash enable its detection by equipment such as the FLIR in use at Mt. Carmel on April 19, 1993; that while flashes obtained in the field appear highly radiant, measurements are necessary to quantify their values; and that the temporal behavior of muzzle flash deserves further study.

  7. MemFlash device: floating gate transistors as memristive devices for neuromorphic computing

    NASA Astrophysics Data System (ADS)

    Riggert, C.; Ziegler, M.; Schroeder, D.; Krautschneider, W. H.; Kohlstedt, H.

    2014-10-01

    Memristive devices are promising candidates for future non-volatile memory applications and mixed-signal circuits. In the field of neuromorphic engineering these devices are especially interesting to emulate neuronal functionality. Therefore, new materials and material combinations are currently investigated, which are often not compatible with Si-technology processes. The underlying mechanisms of the device often remain unclear and are paired with low device endurance and yield. These facts define the current most challenging development tasks towards a reliable memristive device technology. In this respect, the MemFlash concept is of particular interest. A MemFlash device results from a diode configuration wiring scheme of a floating gate transistor, which enables the persistent device resistance to be varied according to the history of the charge flow through the device. In this study, we investigate the scaling conditions of the floating gate oxide thickness with respect to possible applications in the field of neuromorphic engineering. We show that MemFlash cells exhibit essential features with respect to neuromorphic applications. In particular, cells with thin floating gate oxides show a limited synaptic weight growth together with low energy dissipation. MemFlash cells present an attractive alternative for state-of-art memresitive devices. The emulation of associative learning is discussed by implementing a single MemFlash cell in an analogue circuit.

  8. Scannerless loss modulated flash color range imaging

    DOEpatents

    Sandusky, John V [Albuquerque, NM; Pitts, Todd Alan [Rio Rancho, NM

    2008-09-02

    Scannerless loss modulated flash color range imaging methods and apparatus are disclosed for producing three dimensional (3D) images of a target within a scene. Apparatus and methods according to the present invention comprise a light source providing at least three wavelengths (passbands) of illumination that are each loss modulated, phase delayed and simultaneously directed to illuminate the target. Phase delayed light backscattered from the target is spectrally filtered, demodulated and imaged by a planar detector array. Images of the intensity distributions for the selected wavelengths are obtained under modulated and unmodulated (dc) illumination of the target, and the information contained in the images combined to produce a 3D image of the target.

  9. Scannerless loss modulated flash color range imaging

    DOEpatents

    Sandusky, John V [Albuquerque, NM; Pitts, Todd Alan [Rio Rancho, NM

    2009-02-24

    Scannerless loss modulated flash color range imaging methods and apparatus are disclosed for producing three dimensional (3D) images of a target within a scene. Apparatus and methods according to the present invention comprise a light source providing at least three wavelengths (passbands) of illumination that are each loss modulated, phase delayed and simultaneously directed to illuminate the target. Phase delayed light backscattered from the target is spectrally filtered, demodulated and imaged by a planar detector array. Images of the intensity distributions for the selected wavelengths are obtained under modulated and unmodulated (dc) illumination of the target, and the information contained in the images combined to produce a 3D image of the target.

  10. FlashPhotol: Using a Flash Photolysis Apparatus Simulator to Introduce Students to the Kinetics of Transient Species and Fast Reactions

    ERIC Educational Resources Information Center

    Bigger, Stephen W.

    2016-01-01

    FlashPhotol is an educational software package that introduces students to the kinetics of transient species and fast reactions. This is achieved by means of a computer-simulated flash photolysis apparatus that comprises all major functional elements and that students can use to perform various experiments. The experimental interface presents a…

  11. Modeling experimental plasma diagnostics in the FLASH code: Thomson scattering

    NASA Astrophysics Data System (ADS)

    Weide, Klaus; Flocke, Norbert; Feister, Scott; Tzeferacos, Petros; Lamb, Donald

    2017-10-01

    Spectral analysis of the Thomson scattering of laser light sent into a plasma provides an experimental method to quantify plasma properties in laser-driven plasma experiments. We have implemented such a synthetic Thomson scattering diagnostic unit in the FLASH code, to emulate the probe-laser propagation, scattering and spectral detection. User-defined laser rays propagate into the FLASH simulation region and experience scattering (change in direction and frequency) based on plasma parameters. After scattering, the rays propagate out of the interaction region and are spectrally characterized. The diagnostic unit can be used either during a physics simulation or in post-processing of simulation results. FLASH is publicly available at flash.uchicago.edu. U.S. DOE NNSA, U.S. DOE NNSA ASC, U.S. DOE Office of Science and NSF.

  12. Fermi GBM Observations of Terrestrial Gamma Flashes

    NASA Technical Reports Server (NTRS)

    Wilson-Hodge, Colleen A.; Briggs, M. S.; Connaughton, V.; Fishman, G. J.; Bhat, P. N.; Paciesas, W. S.; Preece, R. D.; Kippen, R. M.; vonKienlin, A.; Dwyer, J. R.; hide

    2010-01-01

    In its first two years of operation, the Fermi Gamma Ray Burst Monitor (GBM) has observed 79 Terrestrial Gamma Flashes (TGFs). The thick Bismuth Germanate (BGO) detectors are excellent for TGF spectroscopy, having a high probability of recording the full energy of an incident photon, spanning a broad energy range from 150 keV to 40 MeV, and recording a large number of photons per TGF. Correlations between GBM TGF triggers and lightning sferics detected with the World-Wide Lightning Location Network indicate that TGFs and lightning are simultaneous to within tens of microseconds.

  13. Global Positioning System Synchronized Active Light Autonomous Docking System

    NASA Technical Reports Server (NTRS)

    Howard, Richard T. (Inventor); Book, Michael L. (Inventor); Bryan, Thomas C. (Inventor); Bell, Joseph L. (Inventor)

    1996-01-01

    A Global Positioning System Synchronized Active Light Autonomous Docking System (GPSSALADS) for automatically docking a chase vehicle with a target vehicle comprising at least one active light emitting target which is operatively attached to the target vehicle. The target includes a three-dimensional array of concomitantly flashing lights which flash at a controlled common frequency. The GPSSALADS further comprises a visual tracking sensor operatively attached to the chase vehicle for detecting and tracking the target vehicle. Its performance is synchronized with the flash frequency of the lights by a synchronization means which is comprised of first and second internal clocks operatively connected to the active light target and visual tracking sensor, respectively, for providing timing control signals thereto, respectively. The synchronization means further includes first and second Global Positioning System receivers operatively connected to the first and second internal clocks, respectively, for repeatedly providing simultaneous synchronization pulses to the internal clocks, respectively. In addition, the GPSSALADS includes a docking process controller means which is operatively attached to the chase vehicle and is responsive to the visual tracking sensor for producing commands for the guidance and propulsion system of the chase vehicle.

  14. Global Positioning System Synchronized Active Light Autonomous Docking System

    NASA Technical Reports Server (NTRS)

    Howard, Richard (Inventor)

    1994-01-01

    A Global Positioning System Synchronized Active Light Autonomous Docking System (GPSSALADS) for automatically docking a chase vehicle with a target vehicle comprises at least one active light emitting target which is operatively attached to the target vehicle. The target includes a three-dimensional array of concomitantly flashing lights which flash at a controlled common frequency. The GPSSALADS further comprises a visual tracking sensor operatively attached to the chase vehicle for detecting and tracking the target vehicle. Its performance is synchronized with the flash frequency of the lights by a synchronization means which is comprised of first and second internal clocks operatively connected to the active light target and visual tracking sensor, respectively, for providing timing control signals thereto, respectively. The synchronization means further includes first and second Global Positioning System receivers operatively connected to the first and second internal clocks, respectively, for repeatedly providing simultaneous synchronization pulses to the internal clocks, respectively. In addition, the GPSSALADS includes a docking process controller means which is operatively attached to the chase vehicle and is responsive to the visual tracking sensor for producing commands for the guidance and propulsion system of the chase vehicle.

  15. The Role of Serotonin in Hot Flashes after Breast Cancer

    DTIC Science & Technology

    2009-03-01

    physiological mechanisms involved in hot flashes c.fter breast cancer will enable us to develop more targeted behavioral and/or pharmacological therapi ...s to be used in lieu of, or in addition to, currently available therapies so that we can eradicate hot flashes and improve the quality of life for...flavorings were most palatable - chocolate mint and orange. We rejected a lemon flavoring as being unpalatable. We eliminated the mid-day snack per

  16. Does underwater flash photography affect the behaviour, movement and site persistence of seahorses?

    PubMed

    Harasti, D; Gladstone, W

    2013-11-01

    The effect of flash photography on seahorse species has never been tested. An experiment was established to test the effect of flash photography and the handling of Hippocampus whitei, a medium-sized seahorse species endemic to Australia, on their behavioural responses, movements and site persistence. A total of 24 H. whitei were utilized in the experiment with eight in each of the three treatments (flash photography, handling and control). The effect of underwater flash photography on H. whitei movements was not significant; however, the effect of handling H. whitei to take a photograph had a significant effect on their short-term behavioural responses to the photographer. Kaplan-Meier log-rank test revealed that there was no significant difference in site persistence of H. whitei from each of the three treatments and that flash photography had no long-term effects on their site persistence. It is concluded that the use of flash photography by divers is a safe and viable technique with H. whitei, particularly if photographs can be used for individual identification purposes. © 2013 The Fisheries Society of the British Isles.

  17. Colour Terms Affect Detection of Colour and Colour-Associated Objects Suppressed from Visual Awareness

    PubMed Central

    Forder, Lewis; Taylor, Olivia; Mankin, Helen; Scott, Ryan B.; Franklin, Anna

    2016-01-01

    The idea that language can affect how we see the world continues to create controversy. A potentially important study in this field has shown that when an object is suppressed from visual awareness using continuous flash suppression (a form of binocular rivalry), detection of the object is differently affected by a preceding word prime depending on whether the prime matches or does not match the object. This may suggest that language can affect early stages of vision. We replicated this paradigm and further investigated whether colour terms likewise influence the detection of colours or colour-associated object images suppressed from visual awareness by continuous flash suppression. This method presents rapidly changing visual noise to one eye while the target stimulus is presented to the other. It has been shown to delay conscious perception of a target for up to several minutes. In Experiment 1 we presented greyscale photos of objects. They were either preceded by a congruent object label, an incongruent label, or white noise. Detection sensitivity (d’) and hit rates were significantly poorer for suppressed objects preceded by an incongruent label compared to a congruent label or noise. In Experiment 2, targets were coloured discs preceded by a colour term. Detection sensitivity was significantly worse for suppressed colour patches preceded by an incongruent colour term as compared to a congruent term or white noise. In Experiment 3 targets were suppressed greyscale object images preceded by an auditory presentation of a colour term. On congruent trials the colour term matched the object’s stereotypical colour and on incongruent trials the colour term mismatched. Detection sensitivity was significantly poorer on incongruent trials than congruent trials. Overall, these findings suggest that colour terms affect awareness of coloured stimuli and colour- associated objects, and provide new evidence for language-perception interaction in the brain. PMID:27023274

  18. Colour Terms Affect Detection of Colour and Colour-Associated Objects Suppressed from Visual Awareness.

    PubMed

    Forder, Lewis; Taylor, Olivia; Mankin, Helen; Scott, Ryan B; Franklin, Anna

    2016-01-01

    The idea that language can affect how we see the world continues to create controversy. A potentially important study in this field has shown that when an object is suppressed from visual awareness using continuous flash suppression (a form of binocular rivalry), detection of the object is differently affected by a preceding word prime depending on whether the prime matches or does not match the object. This may suggest that language can affect early stages of vision. We replicated this paradigm and further investigated whether colour terms likewise influence the detection of colours or colour-associated object images suppressed from visual awareness by continuous flash suppression. This method presents rapidly changing visual noise to one eye while the target stimulus is presented to the other. It has been shown to delay conscious perception of a target for up to several minutes. In Experiment 1 we presented greyscale photos of objects. They were either preceded by a congruent object label, an incongruent label, or white noise. Detection sensitivity (d') and hit rates were significantly poorer for suppressed objects preceded by an incongruent label compared to a congruent label or noise. In Experiment 2, targets were coloured discs preceded by a colour term. Detection sensitivity was significantly worse for suppressed colour patches preceded by an incongruent colour term as compared to a congruent term or white noise. In Experiment 3 targets were suppressed greyscale object images preceded by an auditory presentation of a colour term. On congruent trials the colour term matched the object's stereotypical colour and on incongruent trials the colour term mismatched. Detection sensitivity was significantly poorer on incongruent trials than congruent trials. Overall, these findings suggest that colour terms affect awareness of coloured stimuli and colour- associated objects, and provide new evidence for language-perception interaction in the brain.

  19. Measurements of the effective atomic numbers of minerals using bremsstrahlung produced by low-energy electrons

    NASA Astrophysics Data System (ADS)

    Czarnecki, S.; Williams, S.

    2017-12-01

    The accuracy of a method for measuring the effective atomic numbers of minerals using bremsstrahlung intensities has been investigated. The method is independent of detector-efficiency and maximum accelerating voltage. In order to test the method, experiments were performed which involved low-energy electrons incident on thick malachite, pyrite, and galena targets. The resultant thick-target bremsstrahlung was compared to bremsstrahlung produced using a standard target, and experimental effective atomic numbers were calculated using data from a previous study (in which the Z-dependence of thick-target bremsstrahlung was studied). Comparisons of the results to theoretical values suggest that the method has potential for implementation in energy-dispersive X-ray spectroscopy systems.

  20. Theoretical and experimental study of the formation conditions of stepped leaders in negative flashes

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Xie, Shijun, E-mail: sj-xie@163.com; State Key Laboratory of Control and Simulation of Power System and Generation Equipment, Department of Electrical Engineering, Tsinghua University, Beijing 100084; Zeng, Rong

    2015-08-15

    Natural lightning flashes are stochastic and uncontrollable, and thus, it is difficult to observe the formation process of a downward negative stepped leader (NSL) directly and in detail. This situation has led to some dispute over the actual NSL formation mechanism, and thus has hindered improvements in the lightning shielding analysis model. In this paper, on the basis of controllable long air gap discharge experiments, the formation conditions required for NSLs in negative flashes have been studied. First, a series of simulation experiments on varying scales were designed and carried out. The NSL formation processes were observed, and several ofmore » the characteristic process parameters, including the scale, the propagation velocity, and the dark period, were obtained. By comparing the acquired formation processes and the characteristic parameters with those in natural lightning flashes, the similarity between the NSLs in the simulation experiments and those in natural flashes was proved. Then, based on the local thermodynamic equation and the space charge estimation method, the required NSL formation conditions were deduced, and the space background electric field (E{sub b}) was proposed as the primary parameter for NSL formation. Finally, the critical value of E{sub b} required for the formation of NSLs in natural flashes was determined to be approximately 75 kV/m by extrapolation of the results of the simulation experiments.« less

  1. NDCX-II target experiments and simulations

    DOE PAGES

    Barnard, J. J.; More, R. M.; Terry, M.; ...

    2013-06-13

    The ion accelerator NDCX-II is undergoing commissioning at Lawrence Berkeley National Laboratory (LBNL). Its principal mission is to explore ion-driven High Energy Density Physics (HEDP) relevant to Inertial Fusion Energy (IFE) especially in the Warm Dense Matter (WDM) regime. We have carried out hydrodynamic simulations of beam-heated targets for parameters expected for the initial configuration of NDCX-II. For metal foils of order one micron thick (thin targets), the beam is predicted to heat the target in a timescale comparable to the hydrodynamic expansion time for experiments that infer material properties from measurements of the resulting rarefaction wave. We have alsomore » carried out hydrodynamic simulations of beam heating of metallic foam targets several tens of microns thick (thick targets) in which the ion range is shorter than the areal density of the material. In this case shock waves will form and we derive simple scaling laws for the efficiency of conversion of ion energy into kinetic energy of fluid flow. Geometries with a tamping layer may also be used to study the merging of a tamper shock with the end-of-range shock. As a result, this process can occur in tamped, direct drive IFE targets.« less

  2. The Triple-Flash Illusion Reveals a Driving Role of Alpha-Band Reverberations in Visual Perception.

    PubMed

    Gulbinaite, Rasa; İlhan, Barkın; VanRullen, Rufin

    2017-07-26

    The modulatory role of spontaneous brain oscillations on perception of threshold-level stimuli is well established. Here, we provide evidence that alpha-band (∼10 Hz) oscillations not only modulate perception of threshold-level sensory inputs but also can drive perception and generate percepts without a physical stimulus being present. We used the "triple-flash" illusion: Occasional perception of three flashes when only two spatially coincident veridical ones, separated by ∼100 ms, are presented. The illusion was proposed to result from superposition of two hypothetical oscillatory impulse response functions generated in response to each flash: When the delay between flashes matches the period of the oscillation, the superposition enhances a later part of the oscillation that is normally damped; when this enhancement crosses perceptual threshold, a third flash is erroneously perceived (Bowen, 1989). In Experiment 1, we varied stimulus onset asynchrony and validated Bowen's theory: The optimal stimulus onset asynchrony for illusion to occur was correlated, across human subjects (both genders), with the subject-specific impulse response function period determined from a separate EEG experiment. Experiment 2 revealed that prestimulus parietal, but no occipital, alpha EEG phase and power, as well as poststimulus alpha phase-locking, together determine the occurrence of the illusion on a trial-by-trial basis. Thus, oscillatory reverberations create something out of nothing: A third flash where there are only two. SIGNIFICANCE STATEMENT We highlight a novel property of alpha-band (∼10 Hz) oscillations based on three experiments (two EEG and one psychophysics) by demonstrating that alpha-band oscillations do not merely modulate perception, but can also drive perception. We show that human participants report seeing a third flash when only two are presented (the "triple-flash" illusion) most often when the interflash delay matches the period of participant's oscillatory impulse response function reverberating in alpha. Within-subject, the phase and power of ongoing parietal, but not occipital, alpha-band oscillations at the time of the first flash determine illusory percept on a trial-by-trial basis. We revealed a physiologically plausible mechanism that validates and extends the original theoretical account of the triple-flash illusion proposed by Bowen in 1989. Copyright © 2017 the authors 0270-6474/17/377219-12$15.00/0.

  3. Anxiogenic CO2 Stimulus Elicits Exacerbated Hot Flash-like Responses in a Rat Menopause Model and Hot Flashes in Menopausal Women

    PubMed Central

    Federici, Lauren M.; Roth, Sarah Dorsey; Krier, Connie; Fitz, Stephanie D.; Skaar, Todd; Shekhar, Anantha; Carpenter, Janet S.; Johnson, Philip L.

    2016-01-01

    Objective Since longitudinal studies determined that anxiety is a strong risk factor for hot flashes, we hypothesized that an anxiogenic stimulus that signals air hunger (hypercapnic, normoxic gas) would trigger an exacerbated hot flash-associated increase in tail skin temperature (TST) in a rat ovariectomy (OVEX) model of surgical menopause and hot flashes in symptomatic menopausal women. We also assessed TST responses in OVEX serotonin transporter (SERT)+/− rats that models a common polymorphism that is associated with increased climacteric symptoms in menopausal women and increases in anxiety traits. Methods OVEX and sham-OVEX rats (initial experiment) and wildtype and SERT+/− OVEX rats (subsequent experiment) were exposed to a 5 min infusion of 20%CO2 normoxic gas while measuring TST. Menopausal women were given brief 20% and 35%CO2 challenges, and hot flashes were self-reported and objectively verified. Results Compared to controls, OVEX rats had exacerbated increases in TST, and SERT+/− OVEX rats had prolonged TST increases following CO2. Most women reported mild/moderate hot flashes after CO2 challenges, and the hot flash severity to CO2 was positively correlated with daily hot flash frequency. Conclusions The studies demonstrate that this anxiogenic stimulus is capable of inducing cutaneous vasomotor responses in OVEX rats, and eliciting hot flashes in menopausal women. In rats, the severity of the response was mediated by loss of ovarian function and increased anxiety traits (SERT+/−), and, in women, by daily hot flash frequency. These findings may provide insights into anxiety related triggers and genetic risk factors for hot flashes in thermoneutral environments. PMID:27465717

  4. Quasi-monoenergetic protons accelerated by laser radiation pressure and shocks in thin gaseous targets

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    He Minqing; Shao Xi; Liu Chuansheng

    Recent experiments and simulations have demonstrated effective CO{sub 2} laser acceleration of quasi-monoenergetic protons from thick gaseous hydrogen target (of thickness tens of laser wavelengths) via hole boring and shock accelerations. We present here an alternative novel acceleration scheme by combining laser radiation pressure acceleration with shock acceleration of protons in a thin gaseous target of thickness several laser wavelengths. The laser pushes the thin gaseous plasma forward while compressing it with protons trapped in it. We demonstrated the combined acceleration with two-dimensional particle-in-cell simulation and obtained quasi-monoenergetic protons {approx}44 MeV in a gas target of thickness twice of themore » laser wavelength irradiated by circularly polarized CO{sub 2} laser with normalized laser amplitude a{sub 0}=10.« less

  5. Visual search guidance is best after a short delay

    PubMed Central

    Schmidt, Joseph; Zelinsky, Gregory J.

    2011-01-01

    Search displays are typically presented immediately after a target cue, but in the real-world, delays often exist between target designation and search. Experiments 1 and 2 asked how search guidance changes with delay. Targets were cued using a picture or text label, each for 3000ms, followed by a delay up to 9000ms before the search display. Search stimuli were realistic objects, and guidance was quantified using multiple eye movement measures. Text-based cues showed a non-significant trend towards greater guidance following any delay relative to a no-delay condition. However, guidance from a pictorial cue increased sharply 300–600 msec after preview offset. Experiment 3 replicated this guidance enhancement using shorter preview durations while equating the time from cue onset to search onset, demonstrating that the guidance benefit is linked to preview offset rather than a more complete encoding of the target. Experiment 4 showed that enhanced guidance persists even with a mask flashed at preview offset, suggesting an explanation other than visual priming. We interpret our findings as evidence for the rapid consolidation of target information into a guiding representation, which attains its maximum effectiveness shortly after preview offset. PMID:21295053

  6. Visual search guidance is best after a short delay.

    PubMed

    Schmidt, Joseph; Zelinsky, Gregory J

    2011-03-25

    Search displays are typically presented immediately after a target cue, but in the real-world, delays often exist between target designation and search. Experiments 1 and 2 asked how search guidance changes with delay. Targets were cued using a picture or text label, each for 3000ms, followed by a delay up to 9000ms before the search display. Search stimuli were realistic objects, and guidance was quantified using multiple eye movement measures. Text-based cues showed a non-significant trend towards greater guidance following any delay relative to a no-delay condition. However, guidance from a pictorial cue increased sharply 300-600ms after preview offset. Experiment 3 replicated this guidance enhancement using shorter preview durations while equating the time from cue onset to search onset, demonstrating that the guidance benefit is linked to preview offset rather than a more complete encoding of the target. Experiment 4 showed that enhanced guidance persists even with a mask flashed at preview offset, suggesting an explanation other than visual priming. We interpret our findings as evidence for the rapid consolidation of target information into a guiding representation, which attains its maximum effectiveness shortly after preview offset. Copyright © 2011 Elsevier Ltd. All rights reserved.

  7. Flash Radiographic Studies of Hypervelocity Projectile Interactions with Explosives

    DTIC Science & Technology

    1992-07-01

    radiography . Explosive/metal target assemblies were designed to be representative of various aspects of explosive filled ordnance or components. The...with Explosives 1. Introduction Flash radiography (flash X-ray) is an effective instrumentation technique that can be used to record ultra high speed...firing chamber and provide a stable mount for the X-ray tubehead. i_ 11 611 Fmim A \\.\\\\ / \\,\\\\ // "-.. .•\\ /i--" " "’ ’i Xray source ColliatorBase X-ray

  8. An investigation of the phototropic effect on seedling orientation in a microgravity environment: A student involvement project. [radish germination

    NASA Technical Reports Server (NTRS)

    Barainca, J. W.

    1984-01-01

    A microgravity growth chamber was designed to investigate the phototropic response of radish seedlings. Enclosed in a one fourth inch thick, hexagonal, fiberglass-foam spacepak nineteen inches across corners, the experiment consists of a growth chamber and germination tray, a water reservoir and solenoid valve, a fluorescent light for photo simulation, a Minolta X700 camera with programmable back, a 50 mm macro lens and flash, a battery pack, and a computer controller. Two temperature sensors and one light sensor located in the walls of the growth chamber provide temperature and illumination data. A computer provides 8 K command and 34 K data storage capability. The experiment was not activated during the STS flight because a malfunctioning latching relay stuck and reduced the battery power level.

  9. The role of hot electrons in the dynamics of a laser-driven strong converging shock

    DOE PAGES

    Llor Aisa, E.; Ribeyre, X.; Duchateau, G.; ...

    2017-11-30

    Experiments on strong shock excitation in spherical plastic targets conducted at the Omega Laser Facility are interpreted with the radiation–hydrodynamics code CHIC to account for parametric instabilities excitation and hot-electron generation. The effects of hot electrons on the shock-pressure amplification and upstream preheat are analyzed. In this study, it is demonstrated that both effects contribute to an increase in shock velocity. Comparison of the measured laser reflectivity and shock flash time with numerical simulations make it possible to reconstitute the time history of the ablation and shock pressures. Finally, consequences of this analysis for the shock-ignition target design are discussed.

  10. The role of hot electrons in the dynamics of a laser-driven strong converging shock

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Llor Aisa, E.; Ribeyre, X.; Duchateau, G.

    Experiments on strong shock excitation in spherical plastic targets conducted at the Omega Laser Facility are interpreted with the radiation–hydrodynamics code CHIC to account for parametric instabilities excitation and hot-electron generation. The effects of hot electrons on the shock-pressure amplification and upstream preheat are analyzed. In this study, it is demonstrated that both effects contribute to an increase in shock velocity. Comparison of the measured laser reflectivity and shock flash time with numerical simulations make it possible to reconstitute the time history of the ablation and shock pressures. Finally, consequences of this analysis for the shock-ignition target design are discussed.

  11. Effects of monitoring under high and low taskload on detection of flashing and colored radar targets.

    DOT National Transportation Integrated Search

    1990-01-01

    While midair collisions between aircraft are extremely rare occurrences, "near midair" incidents are more common. The present study sought to evaluate the gains in conspicuity that might be realized if flashing or color were added as redundant cues t...

  12. Novel conformal organic antireflective coatings for advanced I-line lithography

    NASA Astrophysics Data System (ADS)

    Deshpande, Shreeram V.; Nowak, Kelly A.; Fowler, Shelly; Williams, Paul; Arjona, Mikko

    2001-08-01

    Flash memory chips are playing a critical role in semiconductor devices due to increased popularity of hand held electronic communication devices such as cell phones and PDAs (personal Digital Assistants). Flash memory offers two primary advantages in semiconductor devices. First, it offers flexibility of in-circuit programming capability to reduce the loss from programming errors and to significantly reduce commercialization time to market for new devices. Second, flash memory has a double density memory capability through stacked gate structures which increases the memory capability and thus saves significantly on chip real estate. However, due to stacked gate structures the requirements for manufacturing of flash memory devices are significantly different from traditional memory devices. Stacked gate structures also offer unique challenges to lithographic patterning materials such as Bottom Anti-Reflective Coating (BARC) compositions used to achieve CD control and to minimize standing wave effect in photolithography. To be applicable in flash memory manufacturing a BARC should form a conformal coating on high topography of stacked gate features as well as provide the normal anti-reflection properties for CD control. In this paper we report on a new highly conformal advanced i-line BARC for use in design and manufacture of flash memory devices. Conformal BARCs being significantly thinner in trenches than the planarizing BARCs offer the advantage of reducing BARC overetch and thus minimizing resist thickness loss.

  13. Compatibility of Motion Facilitates Visuomotor Synchronization

    ERIC Educational Resources Information Center

    Hove, Michael J.; Spivey, Michael J.; Krumhansl, Carol L.

    2010-01-01

    Prior research indicates that synchronized tapping performance is very poor with flashing visual stimuli compared with auditory stimuli. Three finger-tapping experiments compared flashing visual metronomes with visual metronomes containing a spatial component, either compatible, incompatible, or orthogonal to the tapping action. In Experiment 1,…

  14. Cross-modal detection using various temporal and spatial configurations.

    PubMed

    Schirillo, James A

    2011-01-01

    To better understand temporal and spatial cross-modal interactions, two signal detection experiments were conducted in which an auditory target was sometimes accompanied by an irrelevant flash of light. In the first, a psychometric function for detecting a unisensory auditory target in varying signal-to-noise ratios (SNRs) was derived. Then auditory target detection was measured while an irrelevant light was presented with light/sound stimulus onset asynchronies (SOAs) between 0 and ±700 ms. When the light preceded the sound by 100 ms or was coincident, target detection (d') improved for low SNR conditions. In contrast, for larger SOAs (350 and 700 ms), the behavioral gain resulted from a change in both d' and response criterion (β). However, when the light followed the sound, performance changed little. In the second experiment, observers detected multimodal target sounds at eccentricities of ±8°, and ±24°. Sensitivity benefits occurred at both locations, with a larger change at the more peripheral location. Thus, both temporal and spatial factors affect signal detection measures, effectively parsing sensory and decision-making processes.

  15. Optimized ion acceleration using high repetition rate, variable thickness liquid crystal targets

    NASA Astrophysics Data System (ADS)

    Poole, Patrick; Willis, Christopher; Cochran, Ginevra; Andereck, C. David; Schumacher, Douglass

    2015-11-01

    Laser-based ion acceleration is a widely studied plasma physics topic for its applications to secondary radiation sources, advanced imaging, and cancer therapy. Recent work has centered on investigating new acceleration mechanisms that promise improved ion energy and spectrum. While the physics of these mechanisms is not yet fully understood, it has been observed to dominate for certain ranges of target thickness, where the optimum thickness depends on laser conditions including energy, pulse width, and contrast. The study of these phenomena is uniquely facilitated by the use of variable-thickness liquid crystal films, first introduced in P. L. Poole et al. PoP21, 063109 (2014). Control of the formation parameters of these freely suspended films such as volume, temperature, and draw speed allows on-demand thickness variability between 10 nanometers and several 10s of microns, fully encompassing the currently studied thickness regimes with a single target material. The low vapor pressure of liquid crystal enables in-situ film formation and unlimited vacuum use of these targets. Details on the selection and optimization of ion acceleration mechanism with target thickness will be presented, including recent experiments on the Scarlet laser facility and others. This work was performed with support from the DARPA PULSE program through a grant from AMRDEC and by the NNSA under contract DE-NA0001976.

  16. NASA MUST Paper: Infrared Thermography of Graphite/Epoxy

    NASA Technical Reports Server (NTRS)

    Comeaux, Kayla; Koshti, Ajay

    2010-01-01

    The focus of this project is to use Infrared Thermography, a non-destructive test, to detect detrimental cracks and voids beneath the surface of materials used in the space program. This project will consist of developing a simulation model of the Infrared Thermography inspection of the Graphite/Epoxy specimen. The simulation entails finding the correct physical properties for this specimen as well as programming the model for thick voids or flat bottom holes. After the simulation is completed, an Infrared Thermography inspection of the actual specimen will be made. Upon acquiring the experimental test data, an analysis of the data for the actual experiment will occur, which includes analyzing images, graphical analysis, and analyzing numerical data received from the infrared camera. The simulation will then be corrected for any discrepancies between it and the actual experiment. The optimized simulation material property inputs can then be used for new simulation for thin voids. The comparison of the two simulations, the simulation for the thick void and the simulation for the thin void, provides a correlation between the peak contrast ratio and peak time ratio. This correlation is used in the evaluation of flash thermography data during the evaluation of delaminations.

  17. Determining the coordinates of lamps in an illumination dome

    NASA Astrophysics Data System (ADS)

    MacDonald, Lindsay W.; Ahmadabadian, Ali H.; Robson, Stuart

    2015-05-01

    The UCL Dome consists of an acrylic hemisphere of nominal diameter 1030 mm, fitted with 64 flash lights, arranged in three tiers of 16, one tier of 12, and one tier of 4 lights at approximately equal intervals. A Nikon D200 digital camera is mounted on a rigid steel frame at the `north pole' of the dome pointing vertically downwards with its optical axis normal to the horizontal baseboard in the `equatorial' plane. It is used to capture sets of images in pixel register for visualisation and surface reconstruction. Three techniques were employed for the geometric calibration of flash light positions in the dome: (1) the shadow cast by a vertical pin onto graph paper; (2) multi-image photogrammetry with retro-reflective targets; and (3) multi-image photogrammetry using the flash lights themselves as targets. The precision of the coordinates obtained by the three techniques was analysed, and it was found that although photogrammetric methods could locate individual targets to an accuracy of 20 μm, the uncertainty of locating the centroids of the flash lights was approximately 1.5 mm. This result was considered satisfactory for the purposes of using the dome for photometric imaging, and in particular for the visualisation of object surfaces by the polynomial texture mapping (PTM) technique.

  18. Manufacturing of calcium, lithium and molybdenum targets for use in nuclear physics experiments

    NASA Astrophysics Data System (ADS)

    Kheswa, N. Y.; Papka, P.; Buthelezi, E. Z.; Lieder, R. M.; Neveling, R.; Newman, R. T.

    2010-02-01

    This paper describes methods used in the manufacturing of chemically reactive targets such as calcium ( natCa), lithium-6 ( 6Li) and molybdenum-97 ( 97Mo) for nuclear physics experiments at the iThemba LABS cyclotron facility (Faure, South Africa). Due to the chemical properties of these materials a suitable and controlled environment was established in order to minimize oxygen contamination of targets. Calcium was prepared by means of vacuum evaporation while lithium was cold rolled to a desired thickness. In the case of molybdenum, the metallic powder was melted under vacuum using an e-gun followed by cold rolling of the metal bead to a desired thickness. In addition, latest developments toward the establishment of a dedicated nuclear physics target laboratory are discussed.

  19. FLASH2: Operation, beamlines, and photon diagnostics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Plönjes, Elke, E-mail: elke.ploenjes@desy.de; Faatz, Bart; Kuhlmann, Marion

    2016-07-27

    FLASH2, a major extension of the soft X-ray free-electron laser FLASH at DESY, turns FLASH into a multi-user FEL facility. A new undulator line is located in a separate accelerator tunnel and driven additionally by the FLASH linear accelerator. First lasing of FLASH2 was achieved in August 2014 with simultaneous user operation at FLASH1. The new FLASH2 experimental hall offers space for up to six experimental end stations, some of which will be installed permanently. The wide wavelength range spans from 4-60 nm and 0.8 nm in the 5{sup th} harmonic and in the future deep into the water windowmore » in the fundamental. While this is of high interest to users, it is challenging from the beamline instrumentation point of view. Online diagnostics - which are mostly pulse resolved - for beam intensity, position, wavelength, wave front, and pulse length have been to a large extent developed at FLASH(1) and have now been optimized for FLASH2. Pump-probe facilities for XUV-XUV, XUV optical and XUV-THz experiments will complete the FLASH2 user facility.« less

  20. Local thermal pressurization triggered by flash heating causes dramatic weakening in water-saturated gouges at subseismic slip rates

    NASA Astrophysics Data System (ADS)

    Yao, Lu; Ma, Shengli; Shimamoto, Toshihiko; Togo, Tetsuhiro; Chen, Jianye; Kitajima, Hiroko; Wang, Yu; He, Honglin

    2017-04-01

    High-velocity friction studies on water-saturated gouges in recent years have demonstrated that the wet gouges subjected to high-velocity shear tend to have smaller peak and steady-state friction, much shorter slip-weakening distance and lower fracture energy, as compared to the air-dry gouges. Thermal pressurization, compaction-induced pressurization, and flash heating were previously recognized to be the important weakening mechanisms in causing these behaviors. However, in spite of theoretical expectation, there is few evidence to support the occurrence of flash heating in wet gouges, mainly due to the superimposition of multiple weakening mechanisms especially for thermal pressurization. We devised friction experiments to study the role of flash heating in dynamic weakening of water-saturated gouges. In each experiment, we used a pressure vessel to impose a pore pressure of 2.0 MPa on the gouge layer sandwiched between porous ceramics blocks, and applied a long preslide of 1.0 m in displacement before starting the experiment at the target slip rate. By doing so we could (1) suppress rapid thermal pressurization in the bulk gouge layer by means of the designed drained condition and elevated temperature of phase transition of pore water; (2) suppress or even eliminate the pressurization effects due to compaction especially at the very beginning of the experiment. The experiments were performed on a granular gouge (mainly quartz, plagioclase, calcite and illite) and a clay-rich gouge (illite and chlorite ˜58 wt%), which were both collected from the Qingchuan fault of the Longmenshan fault system. For the granular gouge, the steady-state friction coefficients (μss) are 0.39-0.42 at slip rates (V ) of 100 μm/s-10 mm/s; however, at V ≥40 mm/s, the friction coefficients (μ) decrease suddenly at the onset of the slip. For instance, μ reduces by 0.29 within displacement of 0.05-0.08m at V =100 mm/s. For the clay-rich gouge, μss increases from 0.24 to 0.34 as V increasing from 10 μm/s to 100 mm/s. At V =0.4 and 1.0 m/s, the evolutions of friction are characterized by sharp weakening, quick strengthening and slight weakening as slip proceeds. It is noteworthy that the sharp initial weakening is always accompanied by a contemporaneous axial dilatancy of 10-20 μm for both gouges, and the latter friction evolutions are accompanied by axial shortening for the granular gouge and by further dilatancy for the clay-rich gouge. Moreover, microstructure observations reveal that only 40% of the gouge layer was involved in shear deformation for the granular gouge at V =10-100 mm/s, as compared to distributed shear over the entire clay-rich gouge layer at all the tested velocities. The observed data, microstructures and modeling results suggest that flash heating probably triggers thermal pressurization at asperity-contacts or within extremely localized slip zones, causing the sudden initial weakening and contemporaneous dilatancy. The difference in the efficiency of flash heating could explain the different frictional behaviors of the two gouges. Given the extremely fast weakening caused by flash heating and the resulting local thermal pressurization, seismic faults could be weakened more rapidly at much lower slip rates below characteristic weakening velocities previously recognized.

  1. Measuring hot flash phenomenonology using ambulatory prospective digital diaries

    PubMed Central

    Fisher, William I.; Thurston, Rebecca C.

    2016-01-01

    Objective This study provides the description, protocol, and results from a novel prospective ambulatory digital hot flash phenomenon diary. Methods This study included 152 midlife women with daily hot flashes who completed an ambulatory electronic hot flash diary continuously for the waking hours of 3 consecutive days. In this diary, women recorded their hot flashes and accompanying characteristics and associations as the hot flashes occurred. Results Self-reported hot flash severity on the digital diaries indicated that the majority of hot flashes were rated as mild (41.3%) or moderate (43.7%). Severe (13.1%) and very severe (1.8%) hot flashes were less common. Hot flash bother ratings were rated as mild (43%), or moderate (33.5%), with fewer hot flashes reported bothersome (17.5%) or very bothersome (6%). The majority of hot flashes were reported as occurring on the on the face (78.9%), neck (74.7%), and chest (61.3%). Prickly skin was reported concurrently with 32% of hot flashes, 7% with anxiety and 5% with nausea. A novel finding, 38% of hot flashes were accompanied by a premonitory aura. Conclusion A prospective electronic digital hot flash diary allows for a more precise quantitation of hot flashes while overcoming many of the limitations of commonly employed retrospective questionnaires and paper diaries. Unique insights into the phenomenology, loci and associated characteristics of hot flashes were obtained using this device. The digital hot flash phenomenology diary is recommended for future ambulatory studies of hot flashes as a prospective measure of the hot flash experience. PMID:27404030

  2. Measuring hot flash phenomenonology using ambulatory prospective digital diaries.

    PubMed

    Fisher, William I; Thurston, Rebecca C

    2016-11-01

    This study provides the description, protocol, and results from a novel prospective ambulatory digital hot flash phenomenon diary. This study included 152 midlife women with daily hot flashes who completed an ambulatory electronic hot flash diary continuously for the waking hours of three consecutive days. In this diary, women recorded their hot flashes and accompanying characteristics and associations as the hot flashes occurred. Self-reported hot flash severity on the digital diaries indicated that the majority of hot flashes were rated as mild (41.3%) or moderate (43.7%). Severe (13.1%) and very severe (1.8%) hot flashes were less common. Hot flash bother ratings were rated as mild (43%), or moderate (33.5%), with fewer hot flashes reported bothersome (17.5%) or very bothersome (6%). The majority of hot flashes were reported as occurring on the face (78.9%), neck (74.7%), and chest (61.3%). Of all reported hot flashes, 32% occurred concurrently with prickly skin, 7% with anxiety, and 5% with nausea. A novel finding from the study was that 38% of hot flashes were accompanied by a premonitory aura. A prospective electronic digital hot flash diary allows for a more precise quantitation of hot flashes while overcoming many of the limitations of commonly used retrospective questionnaires and paper diaries. Unique insights into the phenomenology, loci, and associated characteristics of hot flashes were obtained using this device. The digital hot flash phenomenology diary is recommended for future ambulatory studies of hot flashes as a prospective measure of the hot flash experience.

  3. Dual-band infrared imaging for quantitative corrosion detection in aging aircraft

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Del Grande, N.K.

    1993-11-01

    Aircraft skin thickness-loss from corrosion has been measured using dual-band infrared (DBIR) imaging on a flash-heated Boeing 737 fuselage structure. We mapped surface temperature differences of 0.2 to 0.6 {degrees}C for 5 to 14% thickness losses within corroded lap splices at 0.4 seconds after the heat flash. Our procedure mapped surface temperature differences at sites without surface-emissivity clutter (from dirt, dents, tape, markings, ink, sealants, uneven paint, paint stripper, exposed metal and roughness variations). We established the correlation of percent thickness loss with surface temperature rise using a partially corroded F-18 wing box and several aluminum panels which had thicknessmore » losses from milled flat-bottom holes. We mapped the lap splice composite thermal inertia, (kpc){sup {1/2}}, which characterized shallow skin defects within the lap splice at early times (<0.3 s) and deeper skin defects within the lap splice at late times (>0.4 s). Corrosion invaded the inside of the Boeing 737 lap splice, beneath the galley and the latrine, where we observed ``pillowing`` from volume build-up of corrosion by-products.« less

  4. Multi-periodic pulsations of a stripped red-giant star in an eclipsing binary system.

    PubMed

    Maxted, Pierre F L; Serenelli, Aldo M; Miglio, Andrea; Marsh, Thomas R; Heber, Ulrich; Dhillon, Vikram S; Littlefair, Stuart; Copperwheat, Chris; Smalley, Barry; Breedt, Elmé; Schaffenroth, Veronika

    2013-06-27

    Low-mass white-dwarf stars are the remnants of disrupted red-giant stars in binary millisecond pulsars and other exotic binary star systems. Some low-mass white dwarfs cool rapidly, whereas others stay bright for millions of years because of stable fusion in thick surface hydrogen layers. This dichotomy is not well understood, so the potential use of low-mass white dwarfs as independent clocks with which to test the spin-down ages of pulsars or as probes of the extreme environments in which low-mass white dwarfs form cannot fully be exploited. Here we report precise mass and radius measurements for the precursor to a low-mass white dwarf. We find that only models in which this disrupted red-giant star has a thick hydrogen envelope can match the strong constraints provided by our data. Very cool low-mass white dwarfs must therefore have lost their thick hydrogen envelopes by irradiation from pulsar companions or by episodes of unstable hydrogen fusion (shell flashes). We also find that this low-mass white-dwarf precursor is a type of pulsating star not hitherto seen. The observed pulsation frequencies are sensitive to internal processes that determine whether this star will undergo shell flashes.

  5. A Modern Apparatus for Performing Flash Chromatography: An Experiment for the Organic Laboratory

    ERIC Educational Resources Information Center

    Naumiec, Gregory R.; Del Padre, Angela N.; Hooper, Matthew M.; Germaine, Alison St.; DeBoef, Brenton

    2013-01-01

    A modern apparatus for performing flash chromatography using commercially available, prepacked silica cartridges has been developed. The key advantage of this system, when compared to traditional flash chromatography, is its use of commercially available silica cartridges, which obviates the need for students to handle silica gel. The apparatus…

  6. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Thornhill, Tom Finley, III; Reinhart, William Dodd; Lawrence, Raymond Jeffery Jr.

    Kill assessment continues to be a major problem for the nation's missile defense program. A potential approach for addressing this issue involves spectral and temporal analysis of the short-time impact flash that occurs when a kill vehicle intercepts and engages a target missile. This can provide identification of the materials involved in the impact event, which will, in turn, yield the data necessary for target identification, engagement analysis, and kill assessment. This report describes the first phases of a project under which we are providing laboratory demonstrations of the feasibility and effectiveness of this approach. We are using two majormore » Sandia facilities, the Z-Pinch accelerator, and the two- and three-stage gas guns at the Shock Thermodynamics and Applied Research (STAR) facility. We have looked at the spectral content of impact flash at velocities up to 25 km/s on the Z-Pinch machine to establish the capability for spectroscopy for these types of events, and are looking at similar experiments at velocities from 6 to 11 km/s on the gas guns to demonstrate a similar capability for a variety of research-oriented and applied materials. The present report describes only the work performed on the Z machine.« less

  7. Strong electromagnetic pulses generated in high-intensity short-pulse laser interactions with thin foil targets

    NASA Astrophysics Data System (ADS)

    Rączka, P.; Dubois, J.-L.; Hulin, S.; Tikhonchuk, V.; Rosiński, M.; Zaraś-Szydłowska, A.; Badziak, J.

    2017-12-01

    Measurements are reported of the target neutralization current, the target charge, and the tangential component of the magnetic field generated as a result of laser-target interaction by pulses with the energy in the range of 45 mJ to 92 mJ on target and the pulse duration from 39 fs to 1000 fs. The experiment was performed at the Eclipse facility in CELIA, Bordeaux. The aim of the experiment was to extend investigations performed for the thick (mm scale) targets to the case of thin (micrometer thickness) targets in a way that would allow for a straightforward comparison of the results. We found that thin foil targets tend to generate 20 to 50 percent higher neutralization current and the target charge than the thick targets. The measurement of the tangential component of the magnetic field had shown that the initial spike is dominated by the 1 ns pulse consistent with the 1 ns pulse of the neutralization current, but there are some differences between targets of different type on sub-ns scale, which is an effect going beyond a simple picture of the target acting as an antenna. The sub-ns structure appears to be reproducible to surprising degree. We found that there is in general a linear correlation between the maximum value of the magnetic field and the maximum neutralization current, which supports the target-antenna picture, except for pulses hundreds of fs long.

  8. Flash Floods Simulation using a Physical-Based Hydrological Model at Different Hydroclimatic Regions

    NASA Astrophysics Data System (ADS)

    Saber, Mohamed; Kamil Yilmaz, Koray

    2016-04-01

    Currently, flash floods are seriously increasing and affecting many regions over the world. Therefore, this study will focus on two case studies; Wadi Abu Subeira, Egypt as arid environment, and Karpuz basin, Turkey as Mediterranean environment. The main objective of this work is to simulate flash floods at both catchments considering the hydrometeorological differences between them which in turn effect their flash flood behaviors. An integrated methodology incorporating Hydrological River Basin Environmental Assessment Model (Hydro-BEAM) and remote sensing observations was devised. Global Satellite Mapping of Precipitation (GSMAP) were compared with the rain gauge network at the target basins to estimate the bias in an effort to further use it effectively in simulation of flash floods. Based on the preliminary results of flash floods simulation on both basins, we found that runoff behaviors of flash floods are different due to the impacts of climatology, hydrological and topographical conditions. Also, the simulated surface runoff hydrographs are reasonably coincide with the simulated ones. Consequently, some mitigation strategies relying on this study could be introduced to help in reducing the flash floods disasters at different climate regions. This comparison of different climatic basins would be a reasonable implication for the potential impact of climate change on the flash floods frequencies and occurrences.

  9. Direct evidence for a position input to the smooth pursuit system.

    PubMed

    Blohm, Gunnar; Missal, Marcus; Lefèvre, Philippe

    2005-07-01

    When objects move in our environment, the orientation of the visual axis in space requires the coordination of two types of eye movements: saccades and smooth pursuit. The principal input to the saccadic system is position error, whereas it is velocity error for the smooth pursuit system. Recently, it has been shown that catch-up saccades to moving targets are triggered and programmed by using velocity error in addition to position error. Here, we show that, when a visual target is flashed during ongoing smooth pursuit, it evokes a smooth eye movement toward the flash. The velocity of this evoked smooth movement is proportional to the position error of the flash; it is neither influenced by the velocity of the ongoing smooth pursuit eye movement nor by the occurrence of a saccade, but the effect is absent if the flash is ignored by the subject. Furthermore, the response started around 85 ms after the flash presentation and decayed with an average time constant of 276 ms. Thus this is the first direct evidence of a position input to the smooth pursuit system. This study shows further evidence for a coupling between saccadic and smooth pursuit systems. It also suggests that there is an interaction between position and velocity error signals in the control of more complex movements.

  10. Small SWAP 3D imaging flash ladar for small tactical unmanned air systems

    NASA Astrophysics Data System (ADS)

    Bird, Alan; Anderson, Scott A.; Wojcik, Michael; Budge, Scott E.

    2015-05-01

    The Space Dynamics Laboratory (SDL), working with Naval Research Laboratory (NRL) and industry leaders Advanced Scientific Concepts (ASC) and Hood Technology Corporation, has developed a small SWAP (size, weight, and power) 3D imaging flash ladar (LAser Detection And Ranging) sensor system concept design for small tactical unmanned air systems (STUAS). The design utilizes an ASC 3D flash ladar camera and laser in a Hood Technology gyro-stabilized gimbal system. The design is an autonomous, intelligent, geo-aware sensor system that supplies real-time 3D terrain and target images. Flash ladar and visible camera data are processed at the sensor using a custom digitizer/frame grabber with compression. Mounted in the aft housing are power, controls, processing computers, and GPS/INS. The onboard processor controls pointing and handles image data, detection algorithms and queuing. The small SWAP 3D imaging flash ladar sensor system generates georeferenced terrain and target images with a low probability of false return and <10 cm range accuracy through foliage in real-time. The 3D imaging flash ladar is designed for a STUAS with a complete system SWAP estimate of <9 kg, <0.2 m3 and <350 W power. The system is modeled using LadarSIM, a MATLAB® and Simulink®- based ladar system simulator designed and developed by the Center for Advanced Imaging Ladar (CAIL) at Utah State University. We will present the concept design and modeled performance predictions.

  11. Engineering Customized TALE Nucleases (TALENs) and TALE Transcription Factors by Fast Ligation-based Automatable Solid-phase High-throughput (FLASH) Assembly

    PubMed Central

    Reyon, Deepak; Maeder, Morgan L.; Khayter, Cyd; Tsai, Shengdar Q.; Foley, Jonathan E.; Sander, Jeffry D.; Joung, J. Keith

    2013-01-01

    Customized DNA-binding domains made using Transcription Activator-Like Effector (TALE) repeats are rapidly growing in importance as widely applicable research tools. TALE nucleases (TALENs), composed of an engineered array of TALE repeats fused to the FokI nuclease domain, have been used successfully for directed genome editing in multiple different organisms and cell types. TALE transcription factors (TALE-TFs), consisting of engineered TALE repeat arrays linked to a transcriptional regulatory domain, have been used to up- or down-regulate expression of endogenous genes in human cells and plants. Here we describe a detailed protocol for practicing the recently described Fast Ligation-based Automatable Solid-phase High-throughput (FLASH) assembly method. FLASH enables automated high-throughput construction of engineered TALE repeats using an automated liquid handling robot or manually using a multi-channel pipet. With the automated version of FLASH, a single researcher can construct up to 96 DNA fragments encoding various length TALE repeat arrays in one day and then clone these to construct sequence-verified TALEN or TALE-TF expression plasmids in one week or less. Plas-mids required to practice FLASH are available by request from the Joung Lab (http://www.jounglab.org/). We also describe here improvements to the Zinc Finger and TALE Targeter (ZiFiT Targeter) webserver (http://ZiFiTBeta.partners.org) that facilitate the design and construction of FLASH TALE repeat arrays in high-throughput. PMID:23821439

  12. 'Flash-forwards' and suicidal ideation: A prospective investigation of mental imagery, entrapment and defeat in a cohort from the Hong Kong Mental Morbidity Survey.

    PubMed

    Ng, Roger M K; Di Simplicio, Martina; McManus, Freda; Kennerley, Helen; Holmes, Emily A

    2016-12-30

    'Flash-forwards' - mental images of suicide - have been reported in selected Caucasian samples. Perceptions of defeat and entrapment are considered to be associated with suicidal ideation. We aimed to investigate (1) the presence of suicidal flash-forwards in people with recent suicidal ideation versus those without such ideation in an Asian sample, and (2) associations between suicidal flash-forwards, and perceptions of entrapment accounting for suicidal ideation. Eighty two suicidal and 80 non-suicidal participants from the Hong Kong Mental Morbidity Survey completed questionnaires including suicidal ideation, presence of suicidal flash-forward images, defeat and entrapment, at baseline and seven weeks later. Suicidal 'flash-forwards' were present only in suicidal cases. People with recent suicidal ideation and suicidal flash-forwards had more severe suicidal ideation than those without flash-forwards. Compared to those without suicidal ideation, people with recent suicidal ideation reported higher entrapment and defeat levels. Resolution of suicidal ideation over time was associated with fewer suicidal flash-forwards and reduced entrapment perceptions. At baseline and seven weeks, suicidal ideation was predicted by an interaction between suicidal flash-forwards presence and perceptions of entrapment. Mental imagery of suicide appears to be associated with suicidal ideation, and may represent a novel target in suicidal risk assessment and prevention. Copyright © 2016 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.

  13. A parametric multivariate drought index and its application in the attribution and projection of flash drought change in China

    NASA Astrophysics Data System (ADS)

    Yuan, X.; Wang, L.; Zhang, M.

    2017-12-01

    Rainfall deficit in the crop growing seasons is usually accompanied by heat waves. Abnormally high temperature increases evapotranspiration and decreases soil moisture rapidly, and ultimately results in a type of drought with a rapid onset, short duration but devastating impact, which is called "Flash drought". With the increase in global temperature, flash drought is expected to occur more frequently. However, there is no consensus on the definition of flash drought so far. Moreover, large uncertainty exists in the estimation of the flash drought and its trend, and the underlying mechanism for its long-term change is not clear. In this presentation, a parametric multivariate drought index that characterizes the joint probability distribution of key variables of flash drought will be developed, and the historical changes in flash drought over China will be analyzed. In addition, a set of land surface model simulations driven by IPCC CMIP5 models with different forcings and future scenarios, will be used for the detection and attribution of flash drought change. This study is targeted at quantifying the influences of natural and anthropogenic climate change on the flash drought change, projecting its future change as well as the corresponding uncertainty, and improving our understanding of the variation of flash drought and its underlying mechanism in a changing climate.

  14. Understanding the creative processes of phenomenological research: The life philosophy of Løgstrup.

    PubMed

    Norlyk, Annelise; Dreyer, Pia; Haahr, Anita; Martinsen, Bente

    2011-01-01

    The creative processes of understanding patients' experiences in phenomenological research are difficult to articulate. Drawing on life philosophy as represented by the Danish philosopher K.E. Løgstrup (1905-1981), this article aims to illustrate Løgstrup's thinking as a way to elaborate the creation of cognition and understanding of patients' experiences. We suggest that Løgstrup's thoughts on sensation can add new dimensions to an increased understanding of the creative process of phenomenological research, and that his thinking can be seen as an epistemological ground for these processes. We argue with Løgstrup that sense-based impressions can facilitate an flash of insight, i.e., the spontaneous, intuitive flash of an idea. Løgstrup stresses that an "flash of insight" is an important source in the creation of cognition and understanding. Relating to three empirical phenomenological studies of patients' experiences, we illustrate how the notions of impression and flash of insight can add new dimensions to increased understanding of the creative processes in phenomenological research that have previously not been discussed. We illustrate that sense-based impressions can facilitate creative flash of insights that open for understanding of patients' experiences in the research process as well as in the communication of the findings. The nature of impression and flash of insight and their relevance in the creation of cognition and understanding contributes to the sparse descriptions in the methodological phenomenological research literature of the creative processes of this research. An elaboration of the creative processes in phenomenological research can help researchers to articulate these processes. Thus, Løgstrup's life philosophy has proven to be valuable in adding new dimensions to phenomenological empirical research as well as embracing lived experience.

  15. Understanding the creative processes of phenomenological research: The life philosophy of Løgstrup

    PubMed Central

    Dreyer, Pia; Haahr, Anita; Martinsen, Bente

    2011-01-01

    The creative processes of understanding patients’ experiences in phenomenological research are difficult to articulate. Drawing on life philosophy as represented by the Danish philosopher K.E. Løgstrup (1905–1981), this article aims to illustrate Løgstrup's thinking as a way to elaborate the creation of cognition and understanding of patients’ experiences. We suggest that Løgstrup's thoughts on sensation can add new dimensions to an increased understanding of the creative process of phenomenological research, and that his thinking can be seen as an epistemological ground for these processes. We argue with Løgstrup that sense-based impressions can facilitate an flash of insight, i.e., the spontaneous, intuitive flash of an idea. Løgstrup stresses that an “flash of insight” is an important source in the creation of cognition and understanding. Relating to three empirical phenomenological studies of patients’ experiences, we illustrate how the notions of impression and flash of insight can add new dimensions to increased understanding of the creative processes in phenomenological research that have previously not been discussed. We illustrate that sense-based impressions can facilitate creative flash of insights that open for understanding of patients’ experiences in the research process as well as in the communication of the findings. The nature of impression and flash of insight and their relevance in the creation of cognition and understanding contributes to the sparse descriptions in the methodological phenomenological research literature of the creative processes of this research. An elaboration of the creative processes in phenomenological research can help researchers to articulate these processes. Thus, Løgstrup's life philosophy has proven to be valuable in adding new dimensions to phenomenological empirical research as well as embracing lived experience. PMID:22076123

  16. Optimization methods for locating lightning flashes using magnetic direction finding networks

    NASA Technical Reports Server (NTRS)

    Goodman, Steven J.

    1989-01-01

    Techniques for producing best point estimates of target position using direction finder bearing information are reviewed. The use of an algorithm that calculates the cloud-to-ground flash location given multiple bearings is illustrated and the position errors are described. This algorithm can be used to analyze direction finder network performance.

  17. Additions and improvements to the high energy density physics capabilities in the FLASH code

    NASA Astrophysics Data System (ADS)

    Lamb, D.; Bogale, A.; Feister, S.; Flocke, N.; Graziani, C.; Khiar, B.; Laune, J.; Tzeferacos, P.; Walker, C.; Weide, K.

    2017-10-01

    FLASH is an open-source, finite-volume Eulerian, spatially-adaptive radiation magnetohydrodynamics code that has the capabilities to treat a broad range of physical processes. FLASH performs well on a wide range of computer architectures, and has a broad user base. Extensive high energy density physics (HEDP) capabilities exist in FLASH, which make it a powerful open toolset for the academic HEDP community. We summarize these capabilities, emphasizing recent additions and improvements. We describe several non-ideal MHD capabilities that are being added to FLASH, including the Hall and Nernst effects, implicit resistivity, and a circuit model, which will allow modeling of Z-pinch experiments. We showcase the ability of FLASH to simulate Thomson scattering polarimetry, which measures Faraday due to the presence of magnetic fields, as well as proton radiography, proton self-emission, and Thomson scattering diagnostics. Finally, we describe several collaborations with the academic HEDP community in which FLASH simulations were used to design and interpret HEDP experiments. This work was supported in part at U. Chicago by DOE NNSA ASC through the Argonne Institute for Computing in Science under FWP 57789; DOE NNSA under NLUF Grant DE-NA0002724; DOE SC OFES Grant DE-SC0016566; and NSF Grant PHY-1619573.

  18. A study on flash sintering and related phenomena in titania and its composite with alumina

    NASA Astrophysics Data System (ADS)

    Shikhar

    In 2010, Cologna et. al. [1] reported that with a help of small electric field 120 Vcm-1, the sintering temperature of 3 mol % yittria stabilized zirconia could be brought down to 850°C from 1450°C. On top of reducing the temperature requirements, the green sample could be sintered from starting density of 50% to near full density in mere 5 seconds, a sintering rate three orders of magnitude higher than conventional methods. This discovery led to the emergence of a new field of enhanced sintering with electric field, named "Flash Sintering". The objective of this thesis is to understand the phenomenological behavior of flash-sintering and related phenomena on titania and its composites with alumina at elevated temperature. The possible mechanisms to explain flash sintering are discussed: Joule heating and the avalanche of defect generation [2], both induced by the rapid rise in conductivity just before the onset of the flash. Apparently, both mechanisms play a role. The thesis covers the response of pure titania and composites of titania-alumina under flash and compared with conventional sintering. We start with the sintering behavior of pure titania and observe lowering of sintering temperature requirements with higher applied electric field. The conductivity of titania during flash is also measured, and compared with the nominal conductivity of titania at equivalent temperatures. The conductivity during flash is determined to be have a different activation energy. For the composites of titania-alumina, effect of flash on the constrained sintering was studied. It is a known fact that sintering of one component of composite slows down when the other component of a different densification rate is added to it, called constrained sintering. In our case, large inclusions of alumina particles were added to nano-grained titania green compact that hindered its densification. Flash sintering was found to be overcoming this problem and near full densification was achieved. In another experiment, effect of high current density and hold time under flash on the chemical reaction (phase transformation) of titania and alumina to form Al2TiO5 is studied. It was found that not only flash enhances the kinetics of reaction when compared with conventional heating at equivalent temperatures, but also brought down the phase transformation temperature for this spinel formation, as reported by the phase diagram. In-situ X-ray diffraction experiments were performed at the synchrotron facility in Argonne National Laboratory. The specimen temperature were measured during the experiment on the basis of peak shift with temperature and were found to be matching with our predicted values by Black-Body-Radiation model. We also observed the instant evolution of texture in grain orientation of pure titania under flash and their disappearance as the fields were switched off. Study on chemical kinetics between titania and alumina were also performed which supported our findings of in-house experiments.

  19. Deconstructing Interocular Suppression: Attention and Divisive Normalization

    PubMed Central

    Li, Hsin-Hung; Carrasco, Marisa; Heeger, David J.

    2015-01-01

    In interocular suppression, a suprathreshold monocular target can be rendered invisible by a salient competitor stimulus presented in the other eye. Despite decades of research on interocular suppression and related phenomena (e.g., binocular rivalry, flash suppression, continuous flash suppression), the neural processing underlying interocular suppression is still unknown. We developed and tested a computational model of interocular suppression. The model included two processes that contributed to the strength of interocular suppression: divisive normalization and attentional modulation. According to the model, the salient competitor induced a stimulus-driven attentional modulation selective for the location and orientation of the competitor, thereby increasing the gain of neural responses to the competitor and reducing the gain of neural responses to the target. Additional suppression was induced by divisive normalization in the model, similar to other forms of visual masking. To test the model, we conducted psychophysics experiments in which both the size and the eye-of-origin of the competitor were manipulated. For small and medium competitors, behavioral performance was consonant with a change in the response gain of neurons that responded to the target. But large competitors induced a contrast-gain change, even when the competitor was split between the two eyes. The model correctly predicted these results and outperformed an alternative model in which the attentional modulation was eye specific. We conclude that both stimulus-driven attention (selective for location and feature) and divisive normalization contribute to interocular suppression. PMID:26517321

  20. Deconstructing Interocular Suppression: Attention and Divisive Normalization.

    PubMed

    Li, Hsin-Hung; Carrasco, Marisa; Heeger, David J

    2015-10-01

    In interocular suppression, a suprathreshold monocular target can be rendered invisible by a salient competitor stimulus presented in the other eye. Despite decades of research on interocular suppression and related phenomena (e.g., binocular rivalry, flash suppression, continuous flash suppression), the neural processing underlying interocular suppression is still unknown. We developed and tested a computational model of interocular suppression. The model included two processes that contributed to the strength of interocular suppression: divisive normalization and attentional modulation. According to the model, the salient competitor induced a stimulus-driven attentional modulation selective for the location and orientation of the competitor, thereby increasing the gain of neural responses to the competitor and reducing the gain of neural responses to the target. Additional suppression was induced by divisive normalization in the model, similar to other forms of visual masking. To test the model, we conducted psychophysics experiments in which both the size and the eye-of-origin of the competitor were manipulated. For small and medium competitors, behavioral performance was consonant with a change in the response gain of neurons that responded to the target. But large competitors induced a contrast-gain change, even when the competitor was split between the two eyes. The model correctly predicted these results and outperformed an alternative model in which the attentional modulation was eye specific. We conclude that both stimulus-driven attention (selective for location and feature) and divisive normalization contribute to interocular suppression.

  1. Numerical Simulation of Laser Ablative Shock Waves From Aluminum in Presence of Helium Gas At Different Ambient Pressures

    NASA Astrophysics Data System (ADS)

    Paturi, Prem Kiran; Durvasula, P. S. L. Kameswari; S, Sai Shiva; Acrhem, University Of Hyderabad Team

    2017-06-01

    A two dimensional comparative study of Laser Ablative Shock Wave into the Aluminum target in the presence of Helium gas at different ambient pressures over a range of 690 - 105 Pa performed using FLASH hydrodynamic codes will be presented. The irradiation of Aluminum target (thickness 2 mm and radius 3 mm) with a 7 ns laser pulse of energy 175 mJ, spot size of 150 µm on the target surface at a wavelength of 532 nm at normal incidence is simulated. Helium gas enclosed in a chamber of height 3 mm and width 3 mm. The electron-ion inverse bremsstrahlung absorption coefficient is considered in the laser energy deposition process. The simulation was performed over a duration of 1 μs. It was observed that an ablative shock is launched into the Helium gas for the pressures of 0.5 atm and above. However, for pressure less than the 0.5 atm the plasma expanded into the He gas upto 12ns and after which due to pressure equilibration with the surroundings and plume splitting shock wave is launched in to Al. Authors acknowledge funding from DRDO, India.

  2. Target depth dependence of damage rate in metals by 150 MeV proton irradiation

    NASA Astrophysics Data System (ADS)

    Yoshiie, T.; Ishi, Y.; Kuriyama, Y.; Mori, Y.; Sato, K.; Uesugi, T.; Xu, Q.

    2015-01-01

    A series of irradiation experiments with 150 MeV protons was performed. The relationship between target depth (or shield thickness) and displacement damage during proton irradiation was obtained by in situ electrical resistance measurements at 20 K. Positron annihilation lifetime measurements were also performed at room temperature after irradiation, as a function of the target thickness. The displacement damage was found to be high close to the beam incident surface area, and decreased with increasing target depth. The experimental results were compared with damage production calculated with an advanced Monte Carlo particle transport code system (PHITS).

  3. Seeing for speaking: Semantic and lexical information provided by briefly presented, naturalistic action scenes

    PubMed Central

    Bölte, Jens; Hofmann, Reinhild; Meier, Claudine C.; Dobel, Christian

    2018-01-01

    At the interface between scene perception and speech production, we investigated how rapidly action scenes can activate semantic and lexical information. Experiment 1 examined how complex action-scene primes, presented for 150 ms, 100 ms, or 50 ms and subsequently masked, influenced the speed with which immediately following action-picture targets are named. Prime and target actions were either identical, showed the same action with different actors and environments, or were unrelated. Relative to unrelated primes, identical and same-action primes facilitated naming the target action, even when presented for 50 ms. In Experiment 2, neutral primes assessed the direction of effects. Identical and same-action scenes induced facilitation but unrelated actions induced interference. In Experiment 3, written verbs were used as targets for naming, preceded by action primes. When target verbs denoted the prime action, clear facilitation was obtained. In contrast, interference was observed when target verbs were phonologically similar, but otherwise unrelated, to the names of prime actions. This is clear evidence for word-form activation by masked action scenes. Masked action pictures thus provide conceptual information that is detailed enough to facilitate apprehension and naming of immediately following scenes. Masked actions even activate their word-form information–as is evident when targets are words. We thus show how language production can be primed with briefly flashed masked action scenes, in answer to long-standing questions in scene processing. PMID:29652939

  4. Capturing Evidence for Past Life in the Martian Loess

    NASA Astrophysics Data System (ADS)

    Schultz, P. H.; Harris, R. S.; Clemett, S. J.; Thomas-Keprta, K. L.; Zárate, M.

    2014-12-01

    Vast loess deposits in Europe and the US accumulated after the last glacial maxima (<20 kyrs). In Argentina, however, they gradually accumulated from dried riverbeds that carried sediments from the Andes over the last 12 myrs [1]. These 300m-thick loessoid deposits resemble the accumulations of unconformable deposits found on Mars, some exceeding 3km in thickness. While short-lived as surface materials on the Earth (e.g., <12 myrs in Argentina), they remain exposed for billions of years on Mars (since the Late Noachian). Unlithified loessoid deposits represent a special target type affecting both crater excavation and melt generation. Craters as large as 20km in diameter may not reach the underlying "basement" (e.g., cratered highlands). Porous targets also result in greater amounts of impact melt derived from different levels [2, 3]. Moreover, melt breccias can be soft captured, buried, and trapped until re-exposed [4]. In Argentina, some folded vesicular glasses as old as 9.3 myrs contain flash-heated yet well-preserved biomatter (down to < 5 microns) including plant materials [5] and even partially vitrified cartilage fragments [6]. The entrained plant materials also contain organic relicts such as derivatives of chlorophyll. This biomatter becomes trapped as the melt is rolled and folded during excavation or emplacement. Exploratory impact experiments at the NASA Ames Vertical Gun Range simulated this process at a much smaller scale (5km/s at 45 deg impact angle). Fragments of wetted Pampas grass and tardigrades buried near the surface were entrained within small, twisted and folded glasses. Grass positioned uprange of the impact, however, survived intact within a projectile radius of the impact point. Consequently, the low impact speeds available in the experiments could be more than offset by an uprange location for a much higher speed impact. While plant material should not be expected, other primitive forms could be mixed within seams and folds within proximal impact melts. [1] Zarate, M. A. (2003), Quat. Sci. Revs. 22, p. 1987-2006; [2] Schultz, P. H. et al. (2004), EPSL, v. 219, 221-238; [3] Schultz, P. H. et al. (2006), MAPS, v. 41, 749-771; [4] Schultz and Mustard (2004), JGR 109, doi: 10.1029/ 2002JE002025; [5] Schultz et al. (2014), Geology, 42, 515-518; [6] Harris and Schultz (2007), LPSC 38, #2306.

  5. Penetration of tungsten-alloy rods into composite ceramic targets: Experiments and 2-D simulations

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rosenberg, Z.; Dekel, E.; Hohler, V.

    1998-07-10

    A series of terminal ballistics experiments, with scaled tungsten-alloy penetrators, was performed on composite targets consisting of ceramic tiles glued to thick steel backing plates. Tiles of silicon-carbide, aluminum nitride, titanium-dibroide and boron-carbide were 20-80 mm thick, and impact velocity was 1.7 km/s. 2-D numerical simulations, using the PISCES code, were performed in order to simulate these shots. It is shown that a simplified version of the Johnson-Holmquist failure model can account for the penetration depths of the rods but is not enough to capture the effect of lateral release waves on these penetrations.

  6. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tomlinson, Kurt; Seagle, C. T.; Huang, H.

    A measurement instrument utilizing dual, chromatic, confocal, distance sensors has been jointly developed by General Atomics (GA) and Sandia National Laboratories (SNL) for thickness and flatness measurement of target components used in dynamic materials properties (DMP) experiments on the SNL Z-Machine (Z). Compared to previous methods used in production of these types of targets, the tool saves time and yields a 4x reduction in thickness uncertainty which is one of the largest sources of error in equation of state (EOS) measurements critical to supporting the NNSA’s Stockpile Stewardship program and computer modeling of high energy density experiments. It has numerousmore » differences from earlier instruments operating on the dual confocal sensor principle to accommodate DMP components including larger lateral travel, longer working distance, ability to measure flatness in addition to thickness, built-in thickness calibration standards for quickly checking calibration before and after each measurement, and streamlined operation. Thickness and flatness of 0.2mm-3.3mm thick sections of diamond machined copper and aluminum can be measured to “sub-micron” accuracy. Sections up to 6mm thick can be measured with as-yet undermined accuracy. Furthermore, samples must have one surface which is flat to within 300µm, lateral dimensions of no more than 50mm x 50mm, and height less than 40mm.« less

  7. Enhanced Dual Confocal Measurement System

    DOE PAGES

    Tomlinson, Kurt; Seagle, C. T.; Huang, H.; ...

    2017-11-29

    A measurement instrument utilizing dual, chromatic, confocal, distance sensors has been jointly developed by General Atomics (GA) and Sandia National Laboratories (SNL) for thickness and flatness measurement of target components used in dynamic materials properties (DMP) experiments on the SNL Z-Machine (Z). Compared to previous methods used in production of these types of targets, the tool saves time and yields a 4x reduction in thickness uncertainty which is one of the largest sources of error in equation of state (EOS) measurements critical to supporting the NNSA’s Stockpile Stewardship program and computer modeling of high energy density experiments. It has numerousmore » differences from earlier instruments operating on the dual confocal sensor principle to accommodate DMP components including larger lateral travel, longer working distance, ability to measure flatness in addition to thickness, built-in thickness calibration standards for quickly checking calibration before and after each measurement, and streamlined operation. Thickness and flatness of 0.2mm-3.3mm thick sections of diamond machined copper and aluminum can be measured to “sub-micron” accuracy. Sections up to 6mm thick can be measured with as-yet undermined accuracy. Furthermore, samples must have one surface which is flat to within 300µm, lateral dimensions of no more than 50mm x 50mm, and height less than 40mm.« less

  8. An Overview of the Lightning - Atmospheric Chemistry Aspects of the Deep Convective Clouds and Chemistry (DC3) Experiment

    NASA Technical Reports Server (NTRS)

    Pickering, K. E.; Barth, M. C.; Koshak, W.; Bucsela, E. J.; Allen, D. J.; Weinheimer, A.; Ryerson, T.; Huntrieser, H.; Bruning, E.; MacGorman, D.; hide

    2012-01-01

    Some of the major goals of the DC3 experiment are to determine the contribution of lightning to NO(x) in the anvils of observed thunderstorms, examine the relationship of lightning NO(x) production to flash rates and to lightning channel lengths, and estimate the relative production per flash for cloud-to-ground flashes and intracloud flashes. In addition, the effects of lightning NO(x) production on photochemistry downwind of thunderstorms is also being examined. The talk will survey the observation types that were conducted during DC3 relevant to these goals and provide an overview of the analysis and modeling techniques which are being used to achieve them. NO(x) was observed on three research aircraft during DC3 (the NCAR G-V, the NASA DC-8, and the DLR Falcon) in flights through storm anvils in three study regions (NE Colorado, Central Oklahoma to West Texas, and northern Alabama) where lightning mapping arrays (LMAs) and radar coverage were available. Initial comparisons of the aircraft NOx observations in storm anvils relative to flash rates have been conducted, which will be followed with calculations of the flux of NO(x) through the anvils, which when combined with observed flash rates can be used to estimate storm-average lightning NOx production per flash. The WRF-Chem model will be run for cloud-resolved simulations of selected observed storms during DC3. Detailed lightning information from the LMAs (flash rates and flash lengths as a function of time and vertical distributions of flash channel segments) will be input to the model along with assumptions concerning NO(x) production per CG flash and per IC flash. These assumptions will be tested through comparisons with the aircraft NOx data from anvil traverses. A specially designed retrieval method for lightning NO2 column amounts from the OMI instrument on NASA fs Aura satellite has been utilized to estimate NO2 over the region affected by selected DC3 storms. Combined with NO(x) to NO2 ratios from the aircraft data and WRF-Chem model and observed flash rates, average NO(x) production per flash can be estimated. Ozone production downwind of observed storms can be estimated from the WRF-Chem simulations and the specific downwind flights.

  9. Permeation fill-tube design for inertial confinement fusion target capsules

    DOE PAGES

    Rice, B. S.; Ulreich, J.; Fella, C.; ...

    2017-03-22

    A unique approach for permeation filling of nonpermeable inertial confinement fusion target capsules with deuterium–tritium (DT) is presented. This process uses a permeable capsule coupled into the final target capsule with a 0.03-mm-diameter fill tube. Leak free permeation filling of glow-discharge polymerization (GDP) targets using this method have been successfully demonstrated, as well as ice layering of the target, yielding an inner ice surface roughness of 1-more » $$\\unicode[STIX]{x03BC}$$m rms (root mean square). Finally, the measured DT ice-thickness profile for this experiment was used to validate a thermal model’s prediction of the same thickness profile.« less

  10. Moderate repetition rate ultra-intense laser targets and optics using variable thickness liquid crystal films

    DOE PAGES

    Poole, P. L.; Willis, C.; Cochran, G. E.; ...

    2016-10-10

    Liquid crystal films are variable thickness, planar targets for ultra-intense laser matter experiments such as ion acceleration. Their target qualities also make them ideal for high-power laser optics such as plasma mirrors and waveplates. By controlling parameters of film formation, thickness can be varied on-demand from 10 nm to above 50 μm, enabling real-time optimization of laser interactions. Presented here are results using a device that draws films from a bulk liquid crystal source volume with any thickness in the aforementioned range. Films form within 2 μm of the same location each time, well within the Rayleigh range of evenmore » tight F/# systems, thus removing the necessity for realignment between shots. As a result, the repetition rate of the device exceeds 0.1 Hz for sub-100nm films, facilitating higher repetition rate operation of modern laser facilities.« less

  11. Moderate repetition rate ultra-intense laser targets and optics using variable thickness liquid crystal films

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Poole, P. L.; Willis, C.; Cochran, G. E.

    Liquid crystal films are variable thickness, planar targets for ultra-intense laser matter experiments such as ion acceleration. Their target qualities also make them ideal for high-power laser optics such as plasma mirrors and waveplates. By controlling parameters of film formation, thickness can be varied on-demand from 10 nm to above 50 μm, enabling real-time optimization of laser interactions. Presented here are results using a device that draws films from a bulk liquid crystal source volume with any thickness in the aforementioned range. Films form within 2 μm of the same location each time, well within the Rayleigh range of evenmore » tight F/# systems, thus removing the necessity for realignment between shots. As a result, the repetition rate of the device exceeds 0.1 Hz for sub-100nm films, facilitating higher repetition rate operation of modern laser facilities.« less

  12. Minimizing the Disruptive Effects of Prospective Memory in Simulated Air Traffic Control

    PubMed Central

    Loft, Shayne; Smith, Rebekah E.; Remington, Roger

    2015-01-01

    Prospective memory refers to remembering to perform an intended action in the future. Failures of prospective memory can occur in air traffic control. In two experiments, we examined the utility of external aids for facilitating air traffic management in a simulated air traffic control task with prospective memory requirements. Participants accepted and handed-off aircraft and detected aircraft conflicts. The prospective memory task involved remembering to deviate from a routine operating procedure when accepting target aircraft. External aids that contained details of the prospective memory task appeared and flashed when target aircraft needed acceptance. In Experiment 1, external aids presented either adjacent or non-adjacent to each of the 20 target aircraft presented over the 40min test phase reduced prospective memory error by 11% compared to a condition without external aids. In Experiment 2, only a single target aircraft was presented a significant time (39min–42min) after presentation of the prospective memory instruction, and the external aids reduced prospective memory error by 34%. In both experiments, costs to the efficiency of non-prospective memory air traffic management (non-target aircraft acceptance response time, conflict detection response time) were reduced by non-adjacent aids compared to no aids or adjacent aids. In contrast, in both experiments, the efficiency of the prospective memory air traffic management (target aircraft acceptance response time) was facilitated by adjacent aids compared to non-adjacent aids. Together, these findings have potential implications for the design of automated alerting systems to maximize multi-task performance in work settings where operators monitor and control demanding perceptual displays. PMID:24059825

  13. Strong electromagnetic pulses generated in laser-matter interactions with 10TW-class fs laser

    NASA Astrophysics Data System (ADS)

    Rączka, Piotr; Rosiński, Marcin; Zaraś-Szydłowska, Agnieszka; Wołowski, Jerzy; Badziak, Jan

    2018-01-01

    The results of an experiment on the generation of electromagnetic pulses (EMP) in the interaction of 10TW fs pulses with thick (mm scale) and thin foil (μm scale) targets are described. Such pulses, with frequencies in the GHz range, may pose a threat to safe and reliable operation of high-power, high-intensity laser facilities. The main point of the experiment is to investigate the fine temporal structure of such pulses using an oscilloscope capable of measurements at very high sampling rate. It is found that the amazing reproducibility of such pulses is confirmed at this high sampling rate. Furthermore, the differences between the EMP signals generated from thick and thin foil targets are clearly seen, which indicates that besides electric polarization of the target and the target neutralization current there may be other factors essential for the EMP emission.

  14. Hot flash report and measurement among Bangladeshi migrants, their London neighbors, and their community of origin.

    PubMed

    Sievert, L L; Begum, K; Sharmeen, T; Murphy, L; Whitcomb, B W; Chowdhury, O; Muttukrishna, S; Bentley, G R

    2016-12-01

    To examine hot flashes in relation to climate and activity patterns, and to compare subjective and objective hot flashes among Bangladeshi immigrants to London, their white London neighbors, and women still living in their community of origin, Sylhet, Bangladesh ("sedentees"). Ninety-five women, aged 40-55, wore the Biolog ambulatory hot flash monitor. Objective measurements and subjective hot flash reports were examined in relation to demographic, reproductive, anthropometric, and lifestyle variables; temperature and humidity at 12:00 and 18:00; and time spent on housework and cooking. Concordance of objective and subjective hot flashes was assessed by Kappa statistics and by sensitivity of hot flash classification. During the study period, Bangladeshi sedentees reported more subjective hot flashes (p < .05), but there was no difference in number of objective hot flashes. White Londoners were more likely to describe hot flashes on their face and neck compared to Bangladeshis (p < .05). Sedentees were more likely to describe hot flashes on their feet (p < .05). Postmenopausal status, increasing parity, and high levels of housework were significant determinants of subjective hot flashes, while ambient temperature and humidity were not. Measures of subjective/objective concordance were low but similar across groups (10-20%). The proportion of objective hot flashes that were also self-reported was lowest among immigrants. Hot flashes were not associated with warmer temperatures, but were associated with housework and with site-specific patterns of cooking. The number of objective hot flash measures did not differ, but differences in subjective experience suggest the influence of culture. © 2016 Wiley Periodicals, Inc.

  15. Flash Inactivation of Oxygen Evolution

    PubMed Central

    Frasch, Wayne D.; Cheniae, George M.

    1980-01-01

    Brief saturating light flashes were used to probe the mechanism of inactivation of O2 evolution by Tris in chloroplasts. Maximum inactivation with a single flash and an oscillation with period of four on subsequent flashes was observed. Analyses of the oscillations suggested that only the charge-collecting O2-evolving catalyst of photosystem II (S2-state) was a target of inactivation by Tris. This conclusion was supported by the following observations: (a) hydroxylamine preequilibration caused a three-flash delay in the inactivation pattern; (b) the lifetimes of the Tris-inactivable and S2-states were similar; and (c) reagents accelerating S2 deactivation decreased the lifetime of the inactivable state. Inactivation proved to be moderated by F, the precursor of Signal IIs, as shown by a one flash delay with chloroplasts having high abundance of F. Evidence was obtained for cooperativity effects in inactivation and NH3 was shown to be a competitive inhibitor of the Tris-induced inactivation. S2-dependent inactivation was inhibited by glutaraldehyde fixation of chloroplasts, possibly suggesting that inactivation proceeds via conformational changes of the S2-state. PMID:16661270

  16. Energy transfer dynamics in strongly inhomogeneous hot-dense-matter systems

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Stillman, C. R.; Nilson, P. M.; Sefkow, A. B.

    Direct measurements of energy transfer across steep density and temperature gradients in a hot-dense-matter system are presented. Hot dense plasma conditions were generated by high-intensity laser irradiation of a thin-foil target containing a buried metal layer. Energy transfer to the layer was measured using picosecond time-resolved x-ray emission spectroscopy. Here, the data show two x-ray flashes in time. Fully explicit, coupled particle-in-cell and collisional-radiative atomic kinetics model predictions reproduce these observations, connecting the two x-ray flashes with staged radial energy transfer within the target.

  17. Energy transfer dynamics in strongly inhomogeneous hot-dense-matter systems

    DOE PAGES

    Stillman, C. R.; Nilson, P. M.; Sefkow, A. B.; ...

    2018-06-25

    Direct measurements of energy transfer across steep density and temperature gradients in a hot-dense-matter system are presented. Hot dense plasma conditions were generated by high-intensity laser irradiation of a thin-foil target containing a buried metal layer. Energy transfer to the layer was measured using picosecond time-resolved x-ray emission spectroscopy. Here, the data show two x-ray flashes in time. Fully explicit, coupled particle-in-cell and collisional-radiative atomic kinetics model predictions reproduce these observations, connecting the two x-ray flashes with staged radial energy transfer within the target.

  18. MRI Quantification of Human Spine Cartilage Endplate Geometry: Comparison With Age, Degeneration, Level, and Disc Geometry

    PubMed Central

    DeLucca, John F.; Peloquin, John M.; Smith, Lachlan J.; Wright, Alexander C.; Vresilovic, Edward J.; Elliott, Dawn M.

    2017-01-01

    Geometry is an important indicator of disc mechanical function and degeneration. While the geometry and associated degenerative changes in the nucleus pulposus and the annulus fibrosus are well-defined, the geometry of the cartilage endplate (CEP) and its relationship to disc degeneration are unknown. The objectives of this study were to quantify CEP geometry in three dimensions using an MRI FLASH imaging sequence and evaluate relationships between CEP geometry and age, degeneration, spinal level, and overall disc geometry. To do so, we assessed the MRI-based measurements for accuracy and repeatability. Next, we measured CEP geometry across a larger sample set and correlated CEP geometric parameters to age, disc degeneration, level, and disc geometry. The MRI-based measures resulted in thicknesses (0.3–1 mm) that are comparable to prior measurements of CEP thickness. CEP thickness was greatest at the anterior/posterior (A/P) margins and smallest in the center. The CEP A/P thickness, axial area, and lateral width decreased with age but were not related to disc degeneration. Age-related, but not degeneration-related, changes in geometry suggest that the CEP may not follow the progression of disc degeneration. Ultimately, if the CEP undergoes significant geometric changes with aging and if these can be related to low back pain, a clinically feasible translation of the FLASH MRI-based measurement of CEP geometry presented in this study may prove a useful diagnostic tool. PMID:27232974

  19. Flakeboard thickness swelling. Part I, Stress relaxation in a flakeboard mat

    Treesearch

    R. L. Geimer; J. H. Kwon; J. Bolton

    1998-01-01

    The steam injection schedule best suited for dimensionally stabilizing a flake mat is one in which steam treatment is initiated before the press is closed and is continued at least until the mat attains target thickness. Experiments showed that resinless mats treated with 20 sec of steam at 600 kPa had maximum thickness swelling of 205% compared to 350% for resinless...

  20. Kappa Agonists as a Novel Therapy for Menopausal Hot Flashes

    PubMed Central

    Oakley, Amy E.; Steiner, Robert A.; Chavkin, Charles; Clifton, Donald K.; Ferrara, Laura K.; Reed, Susan D.

    2015-01-01

    Objective Postmenopausal hot flash etiology is poorly understood, making it difficult to develop and target ideal therapies. A network of hypothalamic estrogen-sensitive neurons producing Kisspeptin, Neurokinin B, and Dynorphin (KNDy neurons), located adjacent to the thermoregulatory center, regulate pulsatile secretion of GnRH and LH. Dynorphin may inhibit this system by binding kappa opioid receptors within the vicinity of KNDy neurons. We hypothesize that hot flashes are reduced by KNDy neuron manipulation. Methods A double-blind, cross-over, placebo-controlled pilot study evaluated the effect of a kappa agonist (KA).Hot flash frequency was the primary outcome. Twelve healthy postmenopausal women with moderate-severe hot flashes, ages 48-60 years, were randomized. Eight women with sufficient baseline hot flashes for statistical analysis completed all 3 interventions: placebo, standard Pentazocine/Naloxone (50/0.5 mg) or low-dose Pentazocine/Naloxone (25/0.25 mg). In an inpatient research setting, each participant received the 3 interventions, in randomized order, on 3 separate days. On each day, an intravenous catheter was inserted for luteinizing hormone (LH) blood sampling, and skin conductance and Holter monitors were placed. Subjective hot flash frequency and severity were recorded. Results Mean hot flash frequency 2-7 hours following therapy initiation was lower than that for placebo (KA standard-dose: 4.75 ± 0.67; KA low-dose: 4.50 ± 0.57; and placebo: 5.94 ± 0.78 hot flashes/5 hours; p =0.025). Hot flash intensity did not vary between interventions. LH pulsatility mirrored objective hot flashes in some, but not all women. Conclusions This pilot suggests that kappa agonists may affect menopausal vasomotor symptoms. PMID:25988798

  1. Mitochondrial Flash: Integrative Reactive Oxygen Species and pH Signals in Cell and Organelle Biology

    PubMed Central

    Gong, Guohua; Wang, Xianhua; Wei-LaPierre, Lan; Cheng, Heping; Dirksen, Robert

    2016-01-01

    Abstract Significance: Recent breakthroughs in mitochondrial research have advanced, reshaped, and revolutionized our view of the role of mitochondria in health and disease. These discoveries include the development of novel tools to probe mitochondrial biology, the molecular identification of mitochondrial functional proteins, and the emergence of new concepts and mechanisms in mitochondrial function regulation. The discovery of “mitochondrial flash” activity has provided unique insights not only into real-time visualization of individual mitochondrial redox and pH dynamics in live cells but has also advanced understanding of the excitability, autonomy, and integration of mitochondrial function in vivo. Recent Advances: The mitochondrial flash is a transient and stochastic event confined within an individual mitochondrion and is observed in a wide range of organisms from plants to Caenorhabditis elegans to mammals. As flash events involve multiple transient concurrent changes within the mitochondrion (e.g., superoxide, pH, and membrane potential), a number of different mitochondrial targeted fluorescent indicators can detect flash activity. Accumulating evidence indicates that flash events reflect integrated snapshots of an intermittent mitochondrial process arising from mitochondrial respiration chain activity associated with the transient opening of the mitochondrial permeability transition pore. Critical Issues: We review the history of flash discovery, summarize current understanding of flash biology, highlight controversies regarding the relative roles of superoxide and pH signals during a flash event, and bring forth the integration of both signals in flash genesis. Future Directions: Investigations using flash as a biomarker and establishing its role in cell signaling pathway will move the field forward. Antioxid. Redox Signal. 25, 534–549. PMID:27245241

  2. Mutational analysis of FLASH and PTPN13 genes in colorectal carcinomas.

    PubMed

    Jeong, Eun Goo; Lee, Sung Hak; Yoo, Nam Jin; Lee, Sug Hyung

    2008-01-01

    The Fas-Fas ligand system is considered a major pathway for induction of apoptosis in cells and tissues. FLASH was identified as a pro-apoptotic protein that transmits apoptosis signal during Fas-mediated apoptosis. PTPN13 interacts with Fas and functions as both suppressor and inducer of Fas-mediated apoptosis. There are polyadenine tracts in both FLASH (A8 and A9 in exon 8) and PTPN13 (A8 in exon 7) genes that could be frameshift mutation targets in colorectal carcinomas. Because genes encoding proteins in Fas-mediated apoptosis frequently harbor somatic mutations in cancers, we explored the possibility as to whether mutations of FLASH and PTPN13 are a feature of colorectal carcinomas. We analysed human FLASH in exon 8 and PTPN13 in exon 7 for the detection of somatic mutations in 103 colorectal carcinomas by a polymerase chain reaction (PCR)- based single-strand conformation polymorphism (SSCP). We detected two mutations in FLASH gene, but none in PTPN13 gene. However, the two mutations were not frameshift (deletion or insertion) mutations in the polyadenine tracts of FLASH. The two mutations consisted of a deletion mutation (c.3734-3737delAGAA) and a missense mutation (c.3703A>C). These data indicate that frameshift mutation in the polyadenine tracts in both FLASH and PTPN13 genes is rare in colorectal carcinomas. Also, the data suggest that both FLASH and PTPN13 mutations in the polyadenine tracts may not have a crucial role in the pathogenesis of colorectal carcinomas.

  3. Secondary light-ion transport from intermediate-energy hadron experiments

    NASA Astrophysics Data System (ADS)

    Srikrishna, Ashwin P.; Castellanos, Luis A.; McGirl, Natalie A.; Heilbronn, Lawrence H.; Tessas, Chiara La; Rusek, Adam; Sivertz, Michael; Blattnig, Steve; Clowdsley, Martha; Slaba, Tony; Zeitlin, Cary

    2017-09-01

    The aim of this research is to produce double differential thick target yields, angular distributions and integrated yields for the inclusive production of neutrons, protons, deuterons, tritons, 3He, and 4He from intermediate heavy-ion interactions on thick targets of aluminium, polyethylene and other targets of interest to the radiation shielding program as specified by the National Aeronautics and Space Administration (NASA). In tandem with the experimental research, transport model calculations of these thick target yields were also performed. The first such experimental run was conducted in May 2015, with the expectation of improved experimental results at a following March 2016 run at the NASA Space Radiation Laboratory (NSRL) on the campus of Brookhaven National Laboratory (BNL). The May 2015 commissioning run served to test the electronics of the experimental setup, as well as the various detectors and other equipment under the conditions in which the following measurements will be run. The series of future accelerator-based experiments will rely on the inclusion of two separate upstream and downstream targets. Analysis of the data from both sets of detectors - liquid scintillator and sodium iodide - using both pulse height and time-of-flight methods will allow NASA to perform uncertainty quantification and sensitivity analysis on their transport codes and future shielding studies.

  4. Thermonuclear flashes on hydrogen/helium accreting carbon monoxide white dwarfs and structure of exotic nuclei

    NASA Astrophysics Data System (ADS)

    Mitchell, Joseph P.

    We studied H-shell flashes on CO WDs accreting Hydrogen rich matter in regimes where they are believed to be on the border of stable accretion and of having dynamical mass loss. These systems are believed to be progenitors of SNe Ia, however, there is still some question of what range of accretion rates and WD masses allow for growth to the Chandrasekhar mass, if any do at all. Flashes that result in mass loss are also of interest as they enrich the Inter Stellar Medium. Use of an explicit hydro code has allowed for the observation of a new physical effect from wave dissipation. With our high time resolution, energy transport via waves, and detailed EOS, we found that at the onset of the flash, a reduction in the degeneracy pressure due to electron captures, results in a reduction of the total pressure. With a gravitational acceleration on the order of 108 in the shell, a reduction of the total pressure by 1% results in an in fall acceleration of 10 kms2 . With such a strong in fall, compressional heating results in a hotter flash, with results showing temperatures over a billion degrees in all models. These high temperatures had consequences on the nucleosynthesis, as they allowed for rp-breakout during the flash. The effect of a "double" flash was found in one model. This resulted when the flash stalled in the H-shell, resulting in high temperature burning in only a portion of the shell. Once the H was exhausted in the flash region, cooling occurred and there was contraction of the H exhausted region. This contraction caused an in fall of the un-exhausted region which via compressional heating resulted in the flash to occur in the un-exhausted region. Such an effect may happen in any progenitor system in which the flash stalls and compression afterwards is suitable for a re-start of the flash. This effect may be observable with the current generation of instruments. With the high temperatures found in the flashes, rp-breakout nucleosynthesis was found to occur. Occurrence of rp-nucleosynthesis in these objects may make important sources of the chemical enrichment of isotopes below the iron group that are not know to be synthesized in hydrostatic stellar burning. The existence of rp-breakout in the flashes, shows the importance of nuclear physics in these objects. More precise nuclear reaction rate data are needed for proper energy generation and chemical evolution. With the occurrence of rp-nucleosynthesis in our models, it is especially advantageous to study radioactive proton rich nuclei. These studies are not without many difficulties in the laboratory, as many of the studies require the use of low intensity radioactive beams making clean, high statistic studies difficult. To address this issue, the hybrid target technique was used. This target technique was found to be a great tool for studying resonant proton scattering with exotic beams. It has been used to measure elastic and inelastic excitation functions in the study of 8B via 7Be+p scattering, as well as 12N+p elastic scattering. With such success, the hybrid target technique can be a very useful tool for studying reactions that are important in the rp-process. We have studied the structure of the astrophysically important, radioactive isotope 8B. Three new resonances have been suggested, a 0+1,2+2 , and 1+2 which were predominantly in the inelastic channel and never before seen in previous studies. However, due to their high excitation energies and narrow width, none of the resonances are expected to effect the astrophysically important 7Be(p, gamma) reaction rate. Results were compared to continuum shell model as well as ab initio calculations and found to be in good agreement with both sets of predictions, with the notable exception of the 2+2 state. (Abstract shortened by UMI.)

  5. A sensitive EUV Schwarzschild microscope for plasma studies with sub-micrometer resolution

    DOE PAGES

    Zastrau, U.; Rodel, C.; Nakatsutsumi, M.; ...

    2018-02-05

    We present an extreme ultraviolet (EUV) microscope using a Schwarzschild objective which is optimized for single-shot sub-micrometer imaging of laser-plasma targets. The microscope has been designed and constructed for imaging the scattering from an EUV-heated solid-density hydrogen jet. Here, imaging of a cryogenic hydrogen target was demonstrated using single pulses of the free-electron laser in Hamburg (FLASH) free-electron laser at a wavelength of 13.5 nm. In a single exposure, we observe a hydrogen jet with ice fragments with a spatial resolution in the sub-micrometer range. In situ EUV imaging is expected to enable novel experimental capabilities for warm dense mattermore » studies of micrometer-sized samples in laser-plasma experiments.« less

  6. A sensitive EUV Schwarzschild microscope for plasma studies with sub-micrometer resolution

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zastrau, U.; Rodel, C.; Nakatsutsumi, M.

    We present an extreme ultraviolet (EUV) microscope using a Schwarzschild objective which is optimized for single-shot sub-micrometer imaging of laser-plasma targets. The microscope has been designed and constructed for imaging the scattering from an EUV-heated solid-density hydrogen jet. Here, imaging of a cryogenic hydrogen target was demonstrated using single pulses of the free-electron laser in Hamburg (FLASH) free-electron laser at a wavelength of 13.5 nm. In a single exposure, we observe a hydrogen jet with ice fragments with a spatial resolution in the sub-micrometer range. In situ EUV imaging is expected to enable novel experimental capabilities for warm dense mattermore » studies of micrometer-sized samples in laser-plasma experiments.« less

  7. Jitter-correction for IR/UV-XUV pump-probe experiments at the FLASH free-electron laser

    DOE PAGES

    Savelyev, Evgeny; Boll, Rebecca; Bomme, Cedric; ...

    2017-04-10

    In pump-probe experiments employing a free-electron laser (FEL) in combination with a synchronized optical femtosecond laser, the arrival-time jitter between the FEL pulse and the optical laser pulse often severely limits the temporal resolution that can be achieved. Here, we present a pump-probe experiment on the UV-induced dissociation of 2,6-difluoroiodobenzene C 6H 3F 2I) molecules performed at the FLASH FEL that takes advantage of recent upgrades of the FLASH timing and synchronization system to obtain high-quality data that are not limited by the FEL arrival-time jitter. Here, we discuss in detail the necessary data analysis steps and describe the originmore » of the time-dependent effects in the yields and kinetic energies of the fragment ions that we observe in the experiment.« less

  8. A Hydrocarbon Fuel Flash Vaporization System for a Pulsed Detonation Engine

    DTIC Science & Technology

    2006-12-01

    Experiments were performed in the Air Force Research Laboratory (AFRL) Pulsed Detonation Research Facility at Wright Patterson AFB, Ohio. The PDE ...AFRL-MN-EG-TP-2006-7420 A HYDROCARBON FUEL FLASH VAPORIZATION SYSTEM FOR A PULSED DETONATION ENGINE (PREPRINT) K. Colin Tucker...85,7<&/$66,),&$7,212) E7(/(3+21(180%(5 ,QFOXGHDUHDFRGH A Hydrocarbon Fuel Flash Vaporization System for a Pulsed Detonation Engine K

  9. Target Fabrication Technology and New Functional Materials for Laser Fusion and Laser-Plasma Experiment

    NASA Astrophysics Data System (ADS)

    Nagai, Keiji; Norimatsu, Takayoshi; Izawa, Yasukazu

    Target fabrication technique is a key issue of laser fusion. We present a comprehensive, up-to-data compilation of laser fusion target fabrication and relating new materials. To achieve highly efficient laser implosion, organic and inorganic highly spherical millimeter-sized capsules and cryogenic hydrogen layers inside should be uniform in diameter and thickness within sub-micrometer ˜ nanometer error. Porous structured targets and molecular cluster targets are required for laser-plasma experiments and applications. Various technologies and new materials concerning above purposes are summarized including fast-ignition targets, equation-of-state measurement targets, high energy ion generation targets, etc.

  10. Mistaking the recent past for the present: false seeing by older adults.

    PubMed

    Jacoby, Larry L; Rogers, Chad S; Bishara, Anthony J; Shimizu, Yujiro

    2012-03-01

    Results of three experiments revealed that older, as compared to young, adults are more reliant on context when "seeing" a briefly flashed word that was preceded by a prime. In a congruent condition, the prime was the same word as flashed (e.g., DIRT dirt) whereas in an incongruent condition, the prime differed in a single letter from the word that was flashed (DART dirt). Following their attempt to identify the flashed word, participants were asked to report whether they had "seen" the flashed word or, instead, had responded on some other basis (knowing or guessing). Older adults showed dramatically higher false seeing by reporting the prime on incongruent trials and claiming to have seen it flashed. This was true even though a titration procedure was used to equate the performance of young and older adults on baseline trials which did not provide a biasing context. Results of Experiment 3 related age differences in false seeing to willingness to respond when given the option to withhold responses. Convergence of results with those showing higher false memory and false hearing are interpreted as evidence that older adults are less able to avoid misleading effects of context. That lessened ability may be associated with decline in frontal lobe functioning.

  11. Penetration experiments in aluminum and Teflon targets of widely variable thickness

    NASA Technical Reports Server (NTRS)

    Hoerz, F.; Cintala, Mark J.; Bernhard, R. P.; See, T. H.

    1994-01-01

    The morphologies and detailed dimensions of hypervelocity craters and penetration holes on space-exposed surfaces faithfully reflect the initial impact conditions. However, current understanding of this postmortem evidence and its relation to such first-order parameters as impact velocity or projectile size and mass is incomplete. While considerable progress is being made in the numerical simulation of impact events, continued impact simulations in the laboratory are needed to obtain empirical constraints and insights. This contribution summarizes such experiments with Al and Teflon targets that were carried out in order to provide a better understanding of the crater and penetration holes reported from the Solar Maximum Mission (SMM) and the Long Duration Exposure Facility (LDEF) satellites. A 5-mm light gas gun was used to fire spherical soda-lime glass projectiles from 50 to 3175 microns in diameter (D(sub P)), at a nominal 6 km/s, into Al (1100 series; annealed) and Teflon (Teflon(sup TFE)) targets. Targets ranged in thickness (T) from infinite halfspace targets (T approx. equals cm) to ultrathin foils (T approx. equals micron), yielding up to 3 degrees of magnitude variation in absolute and relative (D(sub P)/T) target thickness. This experimental matrix simulates the wide range in D(sub P)/T experienced by a space-exposed membrane of constant T that is being impacted by projectiles of widely varying sizes.

  12. Coupling Radar Rainfall Estimation and Hydrological Modelling For Flash-flood Hazard Mitigation

    NASA Astrophysics Data System (ADS)

    Borga, M.; Creutin, J. D.

    Flood risk mitigation is accomplished through managing either or both the hazard and vulnerability. Flood hazard may be reduced through structural measures which alter the frequency of flood levels in the area. The vulnerability of a community to flood loss can be mitigated through changing or regulating land use and through flood warning and effective emergency response. When dealing with flash-flood hazard, it is gener- ally accepted that the most effective way (and in many instances the only affordable in a sustainable perspective) to mitigate the risk is by reducing the vulnerability of the involved communities, in particular by implementing flood warning systems and community self-help programs. However, both the inherent characteristics of the at- mospheric and hydrologic processes involved in flash-flooding and the changing soci- etal needs provide a tremendous challenge to traditional flood forecasting and warning concepts. In fact, the targets of these systems are traditionally localised like urbanised sectors or hydraulic structures. Given the small spatial scale that characterises flash floods and the development of dispersed urbanisation, transportation, green tourism and water sports, human lives and property are exposed to flash flood risk in a scat- tered manner. This must be taken into consideration in flash flood warning strategies and the investigated region should be considered as a whole and every section of the drainage network as a potential target for hydrological warnings. Radar technology offers the potential to provide information describing rain intensities almost contin- uously in time and space. Recent research results indicate that coupling radar infor- mation to distributed hydrologic modelling can provide hydrologic forecasts at all potentially flooded points of a region. Nevertheless, very few flood warning services use radar data more than on a qualitative basis. After a short review of current under- standing in this area, two issues are examined: advantages and caveats of using radar rainfall estimates in operational flash flood forecasting, methodological problems as- sociated to the use of hydrological models for distributed flash flood forecasting with rainfall input estimated from radar.

  13. Utilization of 3D imaging flash lidar technology for autonomous safe landing on planetary bodies

    NASA Astrophysics Data System (ADS)

    Amzajerdian, Farzin; Vanek, Michael; Petway, Larry; Pierrottet, Diego; Busch, George; Bulyshev, Alexander

    2010-01-01

    NASA considers Flash Lidar a critical technology for enabling autonomous safe landing of future large robotic and crewed vehicles on the surface of the Moon and Mars. Flash Lidar can generate 3-Dimensional images of the terrain to identify hazardous features such as craters, rocks, and steep slopes during the final stages of descent and landing. The onboard flight comptuer can use the 3-D map of terain to guide the vehicle to a safe site. The capabilities of Flash Lidar technology were evaluated through a series of static tests using a calibrated target and through dynamic tests aboard a helicopter and a fixed wing airctarft. The aircraft flight tests were perfomed over Moonlike terrain in the California and Nevada deserts. This paper briefly describes the Flash Lidar static and aircraft flight test results. These test results are analyzed against the landing application requirements to identify the areas of technology improvement. The ongoing technology advancement activities are then explained and their goals are described.

  14. Utilization of 3-D Imaging Flash Lidar Technology for Autonomous Safe Landing on Planetary Bodies

    NASA Technical Reports Server (NTRS)

    Amzajerdian, Farzin; Vanek, Michael; Petway, Larry; Pierrotter, Diego; Busch, George; Bulyshev, Alexander

    2010-01-01

    NASA considers Flash Lidar a critical technology for enabling autonomous safe landing of future large robotic and crewed vehicles on the surface of the Moon and Mars. Flash Lidar can generate 3-Dimensional images of the terrain to identify hazardous features such as craters, rocks, and steep slopes during the final stages of descent and landing. The onboard flight computer can use the 3-D map of terrain to guide the vehicle to a safe site. The capabilities of Flash Lidar technology were evaluated through a series of static tests using a calibrated target and through dynamic tests aboard a helicopter and a fixed wing aircraft. The aircraft flight tests were performed over Moon-like terrain in the California and Nevada deserts. This paper briefly describes the Flash Lidar static and aircraft flight test results. These test results are analyzed against the landing application requirements to identify the areas of technology improvement. The ongoing technology advancement activities are then explained and their goals are described.

  15. Throughput increase by adjustment of the BARC drying time with coat track process

    NASA Astrophysics Data System (ADS)

    Brakensiek, Nickolas L.; Long, Ryan

    2005-05-01

    Throughput of a coater module within the coater track is related to the solvent evaporation rate from the material that is being coated. Evaporation rate is controlled by the spin dynamics of the wafer and airflow dynamics over the wafer. Balancing these effects is the key to achieving very uniform coatings across a flat unpatterned wafer. As today"s coat tracks are being pushed to higher throughputs to match the scanner, the coat module throughput must be increased as well. For chemical manufacturers the evaporation rate of the material depends on the solvent used. One measure of relative evaporation rates is to compare flash points of a solvent. The lower the flash point, the quicker the solvent will evaporate. It is possible to formulate products with these volatile solvents although at a price. Shipping and manufacturing a more flammable product increase chances of fire, thereby increasing insurance premiums. Also, the end user of these chemicals will have to take extra precautions in the fab and in storage of these more flammable chemicals. An alternative coat process is possible which would allow higher throughput in a distinct coat module without sacrificing safety. A tradeoff is required for this process, that being a more complicated coat process and a higher viscosity chemical. The coat process uses the fact that evaporation rate depends on the spin dynamics of the wafer by utilizing a series of spin speeds that first would set the thickness of the material followed by a high spin speed to remove the residual solvent. This new process can yield a throughput of over 150 wafers per hour (wph) given two coat modules. The thickness uniformity of less than 2 nm (3 sigma) is still excellent, while drying times are shorter than 10 seconds to achieve the 150 wph throughput targets.

  16. Optimal flash rate and duty cycle for flashing visual indicators.

    NASA Technical Reports Server (NTRS)

    Markowitz, J.

    1971-01-01

    This experiment examined the ability of observers to determine, as quickly as possible, whether a visual indicator was steadily on or flashing. Six flash rates (periods) were combined factorially with three duty cycles (on-off ratios) to define 18 ?types' of intermittent signals. Experimental sessions were divided into six runs of 100 trials, each run utilizing one of the six flash rates. On any given trial in a run, the probability of a steady signal occurring was 0.5 and the probability of a flashing signal occurring was 0.5. A different duty cycle was employed daily for each experimental session. In all, 400 trials were devoted to each of the flash rates at each duty cycle. Accuracy and latency of response were the dependent variables of interest. The results show that the observers view the light for an interval of time appropriate to the expected flash rate and duty cycle; whether they judge the light to be steady or intermittent depends upon whether the light is extinguished during the predetermined waiting period. Adoption of this temporal criterion delays responding in comparison to those tasks involving responses to light onset. The decision or response criteria held by the observers are also sensitive to the parameters of the flashing light: observers become increasingly willing to call a flashing light ?steady' as flash duration increases.

  17. Engineering customized TALE nucleases (TALENs) and TALE transcription factors by fast ligation-based automatable solid-phase high-throughput (FLASH) assembly.

    PubMed

    Reyon, Deepak; Maeder, Morgan L; Khayter, Cyd; Tsai, Shengdar Q; Foley, Jonathan E; Sander, Jeffry D; Joung, J Keith

    2013-07-01

    Customized DNA-binding domains made using transcription activator-like effector (TALE) repeats are rapidly growing in importance as widely applicable research tools. TALE nucleases (TALENs), composed of an engineered array of TALE repeats fused to the FokI nuclease domain, have been used successfully for directed genome editing in various organisms and cell types. TALE transcription factors (TALE-TFs), consisting of engineered TALE repeat arrays linked to a transcriptional regulatory domain, have been used to up- or downregulate expression of endogenous genes in human cells and plants. This unit describes a detailed protocol for the recently described fast ligation-based automatable solid-phase high-throughput (FLASH) assembly method. FLASH enables automated high-throughput construction of engineered TALE repeats using an automated liquid handling robot or manually using a multichannel pipet. Using the automated approach, a single researcher can construct up to 96 DNA fragments encoding TALE repeat arrays of various lengths in a single day, and then clone these to construct sequence-verified TALEN or TALE-TF expression plasmids in a week or less. Plasmids required for FLASH are available by request from the Joung lab (http://eGenome.org). This unit also describes improvements to the Zinc Finger and TALE Targeter (ZiFiT Targeter) web server (http://ZiFiT.partners.org) that facilitate the design and construction of FLASH TALE repeat arrays in high throughput. © 2013 by John Wiley & Sons, Inc.

  18. Using Artificial Soil and Dry-Column Flash Chromatography to Simulate Organic Substance Leaching Process: A Colorful Environmental Chemistry Experiment

    ERIC Educational Resources Information Center

    de Avellar, Isa G. J.; Cotta, Tais A. P. G.; Neder, Amarilis de V. Finageiv

    2012-01-01

    Soil is an important and complex environmental compartment and soil contamination contributes to the pollution of aquifers and other water basins. A simple and low-cost experiment is described in which the mobility of three organic compounds in an artificial soil is examined using dry-column flash chromatography. The compounds were applied on top…

  19. ManPortable and UGV LIVAR: advances in sensor suite integration bring improvements to target observation and identification for the electronic battlefield

    NASA Astrophysics Data System (ADS)

    Lynam, Jeff R.

    2001-09-01

    A more highly integrated, electro-optical sensor suite using Laser Illuminated Viewing and Ranging (LIVAR) techniques is being developed under the Army Advanced Concept Technology- II (ACT-II) program for enhanced manportable target surveillance and identification. The ManPortable LIVAR system currently in development employs a wide-array of sensor technologies that provides the foot-bound soldier and UGV significant advantages and capabilities in lightweight, fieldable, target location, ranging and imaging systems. The unit incorporates a wide field-of-view, 5DEG x 3DEG, uncooled LWIR passive sensor for primary target location. Laser range finding and active illumination is done with a triggered, flash-lamp pumped, eyesafe micro-laser operating in the 1.5 micron region, and is used in conjunction with a range-gated, electron-bombarded CCD digital camera to then image the target objective in a more- narrow, 0.3$DEG, field-of-view. Target range determination is acquired using the integrated LRF and a target position is calculated using data from other onboard devices providing GPS coordinates, tilt, bank and corrected magnetic azimuth. Range gate timing and coordinated receiver optics focus control allow for target imaging operations to be optimized. The onboard control electronics provide power efficient, system operations for extended field use periods from the internal, rechargeable battery packs. Image data storage, transmission, and processing performance capabilities are also being incorporated to provide the best all-around support, for the electronic battlefield, in this type of system. The paper will describe flash laser illumination technology, EBCCD camera technology with flash laser detection system, and image resolution improvement through frame averaging.

  20. Mitochondrial flash as a novel biomarker of mitochondrial respiration in the heart.

    PubMed

    Gong, Guohua; Liu, Xiaoyun; Zhang, Huiliang; Sheu, Shey-Shing; Wang, Wang

    2015-10-01

    Mitochondrial respiration through electron transport chain (ETC) activity generates ATP and reactive oxygen species in eukaryotic cells. The modulation of mitochondrial respiration in vivo or under physiological conditions remains elusive largely due to the lack of appropriate approach to monitor ETC activity in a real-time manner. Here, we show that ETC-coupled mitochondrial flash is a novel biomarker for monitoring mitochondrial respiration under pathophysiological conditions in cultured adult cardiac myocyte and perfused beating heart. Through real-time confocal imaging, we follow the frequency of a transient bursting fluorescent signal, named mitochondrial flash, from individual mitochondria within intact cells expressing a mitochondrial matrix-targeted probe, mt-cpYFP (mitochondrial-circularly permuted yellow fluorescent protein). This mt-cpYFP recorded mitochondrial flash has been shown to be composed of a major superoxide signal with a minor alkalization signal within the mitochondrial matrix. Through manipulating physiological substrates for mitochondrial respiration, we find a close coupling between flash frequency and the ETC electron flow, as measured by oxygen consumption rate in cardiac myocyte. Stimulating electron flow under physiological conditions increases flash frequency. On the other hand, partially block or slowdown electron flow by inhibiting the F0F1 ATPase, which represents a pathological condition, transiently increases then decreases flash frequency. Limiting electron entrance at complex I by knocking out Ndufs4, an assembling subunit of complex I, suppresses mitochondrial flash activity. These results suggest that mitochondrial electron flow can be monitored by real-time imaging of mitochondrial flash. The mitochondrial flash frequency could be used as a novel biomarker for mitochondrial respiration under physiological and pathological conditions. Copyright © 2015 the American Physiological Society.

  1. Strong electromagnetic pulses generated in high-intensity laser-matter interactions

    NASA Astrophysics Data System (ADS)

    Rączka, P.; Dubois, J.-L.; Hulin, S.; Rosiński, M.; Zaraś-Szydłowska, A.; Badziak, J.

    2018-01-01

    Results are reported of an experiment performed at the Eclipse laser facility in CELIA, Bordeaux, on the generation of strong electromagnetic pulses. Measurements were performed of the target neutralization current, the total target charge and the tangential component of the magnetic field for the laser energies ranging from 45 mJ to 92 mJ with the pulse duration approximately 40 fs, and for the pulse durations ranging from 39 fs to 1000 fs, with the laser energy approximately 90 mJ. It was found that the values obtained for thick (mm scale) Cu targets are visibly higher than values reported in previous experiments, which is argued to be a manifestation of a strong dependence of the target electric polarization process on the laser contrast and hence on the amount of preplasma. It was also found that values obtained for thin (μm scale) Al foils were visibly higher than values for thick Cu targets, especially for pulse durations longer than 100 fs. The correlations between the total target charge versus the maximum value of the target neutralization current, and the maximum value of the tangential component of the magnetic field versus the total target charge were analysed. They were found to be in very good agreement with correlations seen in data from previous experiments, which provides a good consistency check on our experimental procedures.

  2. 800-MeV magnetic-focused flash proton radiography for high-contrast imaging of low-density biologically-relevant targets using an inverse-scatter collimator

    NASA Astrophysics Data System (ADS)

    Freeman, Matthew S.; Allison, Jason; Espinoza, Camilo; Goett, John Jerome; Hogan, Gary; Hollander, Brian; Kwiatkowski, Kris; Lopez, Julian; Mariam, Fesseha; Martinez, Michael; Medina, Jason; Medina, Patrick; Merrill, Frank E.; Morley, Deborah; Morris, Chris; Murray, Matthew; Nedrow, Paul; Saunders, Alexander; Schurman, Tamsen; Sisneros, Thomas; Tainter, Amy; Trouw, Frans; Tupa, Dale; Tybo, Josh; Wilde, Carl

    2016-03-01

    Proton radiography shows great promise as a tool to guide proton beam therapy (PBT) in real time. Here, we demonstrate two ways in which the technology may progress towards that goal. Firstly, with a proton beam that is 800 MeV in energy, target tissue receives a dose of radiation with very tight lateral constraint. This could present a benefit over the traditional treatment energies of ~200 MeV, where up to 1 cm of lateral tissue receives scattered radiation at the target. At 800 MeV, the beam travels completely through the object with minimal deflection, thus constraining lateral dose to a smaller area. The second novelty of this system is the utilization of magnetic quadrupole refocusing lenses that mitigate the blur caused by multiple Coulomb scattering within an object, enabling high resolution imaging of thick objects, such as the human body. This system is demonstrated on ex vivo salamander and zebrafish specimens, as well as on a realistic hand phantom. The resulting images provide contrast sufficient to visualize thin tissue, as well as fine detail within the target volumes, and the ability to measure small changes in density. Such a system, combined with PBT, would enable the delivery of a highly specific dose of radiation that is monitored and guided in real time.

  3. Influence of removal of invisible fixation on the saccadic and manual gap effect.

    PubMed

    Ueda, Hiroshi; Takahashi, Kohske; Watanabe, Katsumi

    2014-01-01

    Saccadic and manual reactions to a peripherally presented target are facilitated by removing a central fixation stimulus shortly before a target onset (the gap effect). The present study examined the effects of removal of a visible and invisible fixation point on the saccadic gap effect and the manual gap effect. Participants were required to fixate a central fixation point and respond to a peripherally presented target as quickly and accurately as possible by making a saccade (Experiment 1) or pressing a corresponding key (Experiment 2). The fixation point was dichoptically presented, and visibility was manipulated by using binocular rivalry and continuous flash suppression technique. In both saccade and key-press tasks, removing the visible fixation strongly quickened the responses. Furthermore, the invisible fixation, which remained on the display but suppressed, significantly delayed the saccadic response. Contrarily, the invisible fixation had no effect on the manual task. These results indicate that partially different processes mediate the saccadic gap effect and the manual gap effect. In particular, unconscious processes might modulate an oculomotor-specific component of the saccadic gap effect, presumably via subcortical mechanisms.

  4. Ultra-bright γ-ray flashes and dense attosecond positron bunches from two counter-propagating laser pulses irradiating a micro-wire target.

    PubMed

    Li, Han-Zhen; Yu, Tong-Pu; Hu, Li-Xiang; Yin, Yan; Zou, De-Bin; Liu, Jian-Xun; Wang, Wei-Quan; Hu, Shun; Shao, Fu-Qiu

    2017-09-04

    We propose a novel scheme to generate ultra-bright ultra-short γ-ray flashes and high-energy-density attosecond positron bunches by using multi-dimensional particle-in-cell simulations with quantum electrodynamics effects incorporated. By irradiating a 10 PW laser pulse with an intensity of 10 23 W/cm 2 onto a micro-wire target, surface electrons are dragged-out of the micro-wire and are effectively accelerated to several GeV energies by the laser ponderomotive force, forming relativistic attosecond electron bunches. When these electrons interact with the probe pulse from the other side, ultra-short γ-ray flashes are emitted with an ultra-high peak brightness of 1.8 × 10 24 photons s -1 mm -2 mrad -2 per 0.1%BW at 24 MeV. These photons propagate with a low divergence and collide with the probe pulse, triggering the Breit-Wheeler process. Dense attosecond e - e + pair bunches are produced with the positron energy density as high as 10 17 J/m 3 and number of 10 9 . Such ultra-bright ultra-short γ-ray flashes and secondary positron beams may have potential applications in fundamental physics, high-energy-density physics, applied science and laboratory astrophysics.

  5. Flash Diffusivity Technique Applied to Individual Fibers

    NASA Technical Reports Server (NTRS)

    Mayeaux, Brian; Yowell, Leonard; Wang, Hsin

    2007-01-01

    A variant of the flash diffusivity technique has been devised for determining the thermal diffusivities, and thus the thermal conductivities, of individual aligned fibers. The technique is intended especially for application to nanocomposite fibers, made from narrower fibers of polyphenylene benzobisthiazole (PBZT) and carbon nanotubes. These highly aligned nanocomposite fibers could exploit the high thermal conductivities of carbon nanotubes for thermal-management applications. In the flash diffusivity technique as practiced heretofore, one or more heat pulse(s) is (are) applied to the front face of a plate or disk material specimen and the resulting time-varying temperature on the rear face is measured. Usually, the heat pulse is generated by use of a xenon flash lamp, and the variation of temperature on the rear face is measured by use of an infrared detector. The flash energy is made large enough to produce a usefully high temperature rise on the rear face, but not so large as to significantly alter the specimen material. Once the measurement has been completed, the thermal diffusivity of the specimen is computed from the thickness of the specimen and the time dependence of the temperature variation on the rear face. Heretofore, the infrared detector used in the flash diffusivity technique has been a single-point detector, which responds to a spatial average of the thermal radiation from the rear specimen surface. Such a detector cannot distinguish among regions of differing diffusivity within the specimen. Moreover, two basic assumptions of the thermaldiffusivity technique as practiced heretofore are that the specimen is homogeneous and that heat flows one-dimensionally from the front to the rear face. These assumptions are not valid for an inhomogeneous (composite) material.

  6. Anatomy of a Flash Flood in the Amargosa Desert, U.S.A.

    NASA Astrophysics Data System (ADS)

    Stonestrom, D. A.; Prudic, D. E.; Glancy, P. A.; Beck, D. A.

    2004-12-01

    In August 2004, intense convective rainstorms caused flash flooding throughout the Amargosa River drainage network, temporarily closing Death Valley National Park and causing two fatalities when runoff from Furnace Creek and other channels overtopped roadways in the Park. In 1998, we began installing streambed temperature loggers, pressure transducers, and scour chains in the normally dry channel and selected tributaries of the river in the Amargosa Desert and Oasis Valley. The primary objective of this work is to improve understanding of ground-water recharge from ephemeral streamflows under current climatic conditions. Two weeks after the flash flooding, we visited instrumented sites and estimated peak flows by surveying high-water marks and corresponding channel geometries. Time series of temperatures and stages, together with peak-flow estimates, reveal the routing and evolution of distinct flood pulses in the upper Amargosa River basin. The data also reveal previously undocumented details of individual flash-flood hydrographs, including initial and subsequent flood pulses at two sites. Arid environments are prone to flash flooding not only because vegetation is sparse, but also because the surface-water network is decoupled from underlying ground water by a thick unsaturated zone. Nonlinear interactions between runoff (with energy potentials on the order of a meter of head) and the unsaturated zone (with energy potentials on the order of negative hundreds of meters of head) keep advancing fronts of flood pulses sharp. Profiles of water content beneath the main channel before and after the passage of a flood pulse, together with down-channel attenuation of flow volume within individual pulses, show the leaky nature of dry alluvial channels and the efficiency at which flash floods become potential recharge.

  7. Fabrication and characterization of carbon-backed thin 208Pb targets.

    PubMed

    Thakur, Meenu; Dubey, R; Abhilash, S R; Behera, B R; Mohanty, B P; Kabiraj, D; Ojha, Sunil; Duggal, Heena

    2016-01-01

    Thin carbon-backed isotopically enriched 208 Pb targets were required for our experiment aimed to study the reaction dynamics for 48 Ti +  208 Pb system, populating the near super-heavy nucleus 256 Rf, through mass-energy correlation of the fission fragments. Purity and thickness of the targets are of utmost importance in such studies as these factors have strong influence on the measurement accuracy of mass and energy distribution of fission fragments. 208 Pb targets with thickness ranging from 60 μg/cm 2 to 250 μg/cm 2 have been fabricated in high vacuum environment using physical vapor deposition method. Important points in the method are as follows: • 208 Pb was deposited using resistive heating method, whereas carbon (backing foil) deposition was performed by using the electron beam bombardment technique.•Different characterization techniques such as Particle Induced X-ray Emission (PIXE), Energy Dispersive X-Ray Fluorescence (EDXRF) and Rutherford Backscattering Spectrometry (RBS) were used to assert the purity and thickness of the targets.•These targets have successfully been used to accomplish our experimental objectives.

  8. Space-Time Characterization of Laser Plasma Interactions in the Warm Dense Matter Regime

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cao, L F; Uschmann, I; Forster, E

    2008-04-30

    Laser plasma interaction experiments have been performed using a fs Titanium Sapphire laser. Plasmas have been generated from planar PMMA targets using single laser pulses with 3.3 mJ pulse energy, 50 fs pulse duration at 800 nm wavelength. The electron density distributions of the plasmas in different delay times have been characterized by means of Nomarski Interferometry. Experimental data were compared with hydrodynamic simulation. First results to characterize the plasma density and temperature as a function of space and time are obtained. This work aims to generate plasmas in the warm dense matter (WDM) regime at near solid-density in anmore » ultra-fast laser target interaction process. Plasmas under these conditions can serve as targets to develop x-ray Thomson scattering as a plasma diagnostic tool, e.g., using the VUV free-electron laser (FLASH) at DESY Hamburg.« less

  9. Temporal Binding Window of the Sound-Induced Flash Illusion in Amblyopia.

    PubMed

    Narinesingh, Cindy; Goltz, Herbert C; Wong, Agnes M F

    2017-03-01

    Amblyopia is a neurodevelopmental visual disorder caused by abnormal visual experience in childhood. In addition to known visual deficits, there is evidence for changes in audiovisual integration in amblyopia using explicit tasks. We examined audiovisual integration in amblyopia using an implicit task that is more relevant in a real-world context. A total of 11 participants with amblyopia and 16 controls were tested binocularly and monocularly on the sound-induced flash illusion, in which flashes and beeps are presented concurrently and the perceived number of flashes is influenced by the number of beeps. The task used 1 to 2 rapid peripheral flashes presented with 0 to 2 beeps, at 5 stimulus onset asynchronies, that is, beep (-200 milliseconds, -100 milliseconds) or flash leading (100 milliseconds, 200 milliseconds) or simultaneous (0 milliseconds). Participants reported the number of perceived flashes. Susceptibility was indicated by a "2 flashes" response to "fission" (1 flash, 2 beeps) or "1 flash" to "fusion" (2 flashes, 1 beep). For fission with the beep leading during binocular viewing, controls showed an expected decrease in illusion strength as stimulus onset asynchronies increased, whereas the illusion strength remained constant in participants with amblyopia, indicating a wider temporal binding window in amblyopia (P = 0.007). For fusion, participants with amblyopia showed reduced illusion strength during amblyopic eye viewing (P = 0.044) with the flash leading. Amblyopia is associated with the widening of the temporal binding window, specifically for fission when viewing binocularly with the beep leading. This suggests a developmental adaptation to delayed amblyopic eye visual processing to optimize audiovisual integration.

  10. Preparation of iridium targets by electrodeposition for neutron capture cross section measurements

    DOE PAGES

    Bond, Evelyn M.; Moody, W. Allen; Arnold, Charles; ...

    2016-03-01

    Here, the preparation of 191Ir and 193Ir electrodeposits for neutron capture cross-section measurements at the detector for advanced neutron capture experiments located at the at Los Alamos Neutron Science Center is described. The electrodeposition of iridium in the desired thickness of 0.4–1 mg/cm 2 is challenging. Better yields and thicknesses were obtained using electrodeposition from isopropyl alcohol solutions than from ammonium sulfate solutions. 191Ir and 193Ir targets were initially prepared using the standard single-sided electrodeposition cell. Iridium electrodepositions using a double-sided electrodeposition cell were developed and were optimized, resulting in thick, uniform iridium deposits. LA UR 15-22475.

  11. Fast-moving dislocations trigger flash weakening in carbonate-bearing faults during earthquakes.

    PubMed

    Spagnuolo, Elena; Plümper, Oliver; Violay, Marie; Cavallo, Andrea; Di Toro, Giulio

    2015-11-10

    Rupture fronts can cause fault displacement, reaching speeds up to several ms(-1) within a few milliseconds, at any distance away from the earthquake nucleation area. In the case of silicate-bearing rocks the abrupt slip acceleration results in melting at asperity contacts causing a large reduction in fault frictional strength (i.e., flash weakening). Flash weakening is also observed in experiments performed in carbonate-bearing rocks but evidence for melting is lacking. To unravel the micro-physical mechanisms associated with flash weakening in carbonates, experiments were conducted on pre-cut Carrara marble cylinders using a rotary shear apparatus at conditions relevant to earthquakes propagation. In the first 5 mm of slip the shear stress was reduced up to 30% and CO2 was released. Focused ion beam, scanning and transmission electron microscopy investigations of the slipping zones reveal the presence of calcite nanograins and amorphous carbon. We interpret the CO2 release, the formation of nanograins and amorphous carbon to be the result of a shock-like stress release associated with the migration of fast-moving dislocations. Amorphous carbon, given its low friction coefficient, is responsible for flash weakening and promotes the propagation of the seismic rupture in carbonate-bearing fault patches.

  12. First demonstration of multi-MeV proton acceleration from a cryogenic hydrogen ribbon target

    NASA Astrophysics Data System (ADS)

    Kraft, Stephan D.; Obst, Lieselotte; Metzkes-Ng, Josefine; Schlenvoigt, Hans-Peter; Zeil, Karl; Michaux, Sylvain; Chatain, Denis; Perin, Jean-Paul; Chen, Sophia N.; Fuchs, Julien; Gauthier, Maxence; Cowan, Thomas E.; Schramm, Ulrich

    2018-04-01

    We show efficient laser driven proton acceleration up to 14 MeV from a 62 μm thick cryogenic hydrogen ribbon. Pulses of the short pulse laser ELFIE at LULI with a pulse length of ≈350 fs at an energy of 8 J per pulse are directed onto the target. The results are compared to proton spectra from metal and plastic foils with different thicknesses and show a similarly good performance both in maximum energy as well as in proton number. Thus, this target type is a promising candidate for experiments with high repetition rate laser systems.

  13. First demonstration of multi-MeV proton acceleration from a cryogenic hydrogen ribbon target

    DOE PAGES

    Kraft, Stephan; Obst, Lieselotte; Metzkes-Ng, Josefine; ...

    2018-02-09

    We show efficient laser driven proton acceleration up to 14 MeV from a 50 μm thick cryogenic hydrogen ribbon. Pulses of the short pulse laser ELFIE at LULI with a pulse length of ≈ 350 fs at an energy of 8 J per pulse are directed onto the target. The results were then compared to proton spectra from metal and plastic foils with different thicknesses and show a similar good performance both in maximum energy as well as in proton number. Thus, this target type is a promising candidate for experiments with high repetition rate laser systems.

  14. First demonstration of multi-MeV proton acceleration from a cryogenic hydrogen ribbon target

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kraft, Stephan; Obst, Lieselotte; Metzkes-Ng, Josefine

    We show efficient laser driven proton acceleration up to 14 MeV from a 50 μm thick cryogenic hydrogen ribbon. Pulses of the short pulse laser ELFIE at LULI with a pulse length of ≈ 350 fs at an energy of 8 J per pulse are directed onto the target. The results were then compared to proton spectra from metal and plastic foils with different thicknesses and show a similar good performance both in maximum energy as well as in proton number. Thus, this target type is a promising candidate for experiments with high repetition rate laser systems.

  15. Report on in-situ studies of flash sintering of uranium dioxide

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Raftery, Alicia Marie

    Flash sintering is a novel type of field assisted sintering that uses an electric field and current to provide densification of materials on very short time scales. The potential for field assisted sintering techniques to be used in producing nuclear fuel is gaining recognition due to the potential economic benefits and improvements in material properties. The flash sintering behavior has so far been linked to applied and material parameters, but the underlying mechanisms active during flash sintering have yet to be identified. This report summarizes the efforts to investigate flash sintering of uranium dioxide using dilatometer studies at Los Alamosmore » National Laboratory and two separate sets of in-situ studies at Brookhaven National Laboratory’s NSLS-II XPD-1 beamline. The purpose of the dilatometer studies was to understand individual parameter (applied and material) effects on the flash behavior and the purpose of the in-situ studies was to better understand the mechanisms active during flash sintering. As far as applied parameters, it was found that stoichiometry, or oxygen-to-metal ratio, has a significant effect on the flash behavior (time to flash and speed of flash). Composite systems were found to have degraded sintering behavior relative to pure UO 2. The critical field studies are complete for UO 2.00 and will be analyzed against an existing model for comparison. The in-situ studies showed that the strength of the field and current are directly related to the sample temperature, with temperature-driven phase changes occurring at high values. The existence of an ‘incubation time’ has been questioned, due to a continuous change in lattice parameter values from the moment that the field is applied. Some results from the in-situ experiments, which should provide evidence regarding ion migration, are still being analyzed. Some preliminary conclusions can be made from these results with regard to using field assisted sintering to fabricate nuclear fuel. First, the pure UO 2-based system shows promising behavior with flash sintering, but composite systems are likely to show better sintering behavior with spark plasma sintering. Efforts to develop these methods should therefore be tailored towards the likelihood of success. Additionally, modeling is a rapidly developing aspect of current flash sintering research and should be used in parallel with experiments. Ultimately, ongoing flash sintering studies on various materials, like those summarized in this report, are rapidly contributing to the feasibility of controlling this method for use in the future.« less

  16. Drogue tracking using 3D flash lidar for autonomous aerial refueling

    NASA Astrophysics Data System (ADS)

    Chen, Chao-I.; Stettner, Roger

    2011-06-01

    Autonomous aerial refueling (AAR) is an important capability for an unmanned aerial vehicle (UAV) to increase its flying range and endurance without increasing its size. This paper presents a novel tracking method that utilizes both 2D intensity and 3D point-cloud data acquired with a 3D Flash LIDAR sensor to establish relative position and orientation between the receiver vehicle and drogue during an aerial refueling process. Unlike classic, vision-based sensors, a 3D Flash LIDAR sensor can provide 3D point-cloud data in real time without motion blur, in the day or night, and is capable of imaging through fog and clouds. The proposed method segments out the drogue through 2D analysis and estimates the center of the drogue from 3D point-cloud data for flight trajectory determination. A level-set front propagation routine is first employed to identify the target of interest and establish its silhouette information. Sufficient domain knowledge, such as the size of the drogue and the expected operable distance, is integrated into our approach to quickly eliminate unlikely target candidates. A statistical analysis along with a random sample consensus (RANSAC) is performed on the target to reduce noise and estimate the center of the drogue after all 3D points on the drogue are identified. The estimated center and drogue silhouette serve as the seed points to efficiently locate the target in the next frame.

  17. High Intensity e-beam Diode Development for Flash X-ray Radiography

    NASA Astrophysics Data System (ADS)

    Oliver, Bryan

    2007-11-01

    A variety of electron beam diodes are being used and developed for the purpose of creating high-brightness, flash x-ray radiography sources. In these diodes, high energy (multi MeV), high current (multi kA), small spot (multi mm) electron beams are generated and stopped in high atomic number anode-targets (typically Ta or W). Beam stopping in the target creates copious amounts of bremsstrahlung radiation. In addition, beam heating of the target liberates material, either in the form of low density (˜10^12-10^14 cm-3) ion emission or higher density (> 10^15 cm-3) plasma. In all cases, beam/target collective effects dominate the diode and beam characteristics, affecting the radiation properties (dose and spot-size). Recent experiments at Sandia National Laboratories have demonstrated diodes capable of producing > 350 rad@m with 1.7mm FWHM x-ray source distributions. A review of our present theoretical understanding of the diode (s) operation and our experimental and simulation methods to investigate them will be presented. Emphasis will be given to e- beam sources used on state-of-the-art Inductive Voltage Adder (IVA) pulsed-power accelerators. In particular, the physics of magnetically pinched diodes (e.g. the rod-pinch [1,2]), gas-cell focusing diodes [3] and the magnetically immersed [4] diode will be discussed. Various proposed methods to optimize the x-ray intensity and the direction of future diode research will be discussed. [1] G. Cooperstein, et al., Phys. Plasmas 8, 4618 (2001).[2] B.V. Oliver et al., Phys. Plasmas 11, 3976 (2004)[3] B.V. Oliver, et al., IEEE Trans. on Plasma Science 33, 704 (2005).[4] M.G. Mazarakis, et al., Appl. Phys. Lett. 70, 832 (1997)

  18. Circulating interleukin-8 and tumor necrosis factor-α are associated with hot flashes in healthy postmenopausal women.

    PubMed

    Huang, Wan-Yu; Hsin, I-Lun; Chen, Dar-Ren; Chang, Chia-Chu; Kor, Chew-Teng; Chen, Ting-Yu; Wu, Hung-Ming

    2017-01-01

    Hot flashes have been postulated to be linked to systemic inflammation. This study aimed to investigate the relationship between hot flashes, pro-inflammatory factors, and leukocytes in healthy, non-obese postmenopausal women. In this cross-sectional study, a total of 202 women aged 45-60 years were stratified into one of four groups according to their hot-flash status: never experienced hot flashes (Group N), mild hot flashes (Group m), moderate hot flashes (Group M), and severe hot flashes (Group S). Variables measured in this study included clinical parameters, hot flash experience, leukocytes, and fasting plasma levels of nine circulating cytokines/chemokines measured by using multiplex assays. Multiple linear regression analysis was used to evaluate the associations of hot flashes with these pro-inflammatory factors. The study was performed in a hospital medical center. The mean values of leukocyte number were not different between these four groups. The hot flash status had a positive tendency toward increased levels of circulating IL-6 (P-trend = 0.049), IL-8 (P-trend < 0.001), TNF-α (P-trend = 0.008), and MIP1β (P-trend = 0.04). Multivariate linear regression analysis revealed that hot-flash severity was significantly associated with IL-8 (P-trend < 0.001) and TNFα (P-trend = 0.007) among these nine cytokines/chemokines after adjustment for age, menopausal duration, BMI and FSH. Multivariate analysis further revealed that severe hot flashes were strongly associated with a higher IL-8 (% difference, 37.19%; 95% confidence interval, 14.98,63.69; P < 0.001) and TNFα (51.27%; 6.64,114.57; P < 0.05). The present study provides evidence that hot flashes are associated with circulating IL-8 and TNF-α in healthy postmenopausal women. It suggests that hot flashes might be related to low-grade systemic inflammation.

  19. Circulating interleukin-8 and tumor necrosis factor-α are associated with hot flashes in healthy postmenopausal women

    PubMed Central

    Huang, Wan-Yu; Hsin, I-Lun; Chen, Dar-Ren; Chang, Chia-Chu; Kor, Chew-Teng; Chen, Ting-Yu

    2017-01-01

    Introduction Hot flashes have been postulated to be linked to systemic inflammation. This study aimed to investigate the relationship between hot flashes, pro-inflammatory factors, and leukocytes in healthy, non-obese postmenopausal women. Participants and design In this cross-sectional study, a total of 202 women aged 45–60 years were stratified into one of four groups according to their hot-flash status: never experienced hot flashes (Group N), mild hot flashes (Group m), moderate hot flashes (Group M), and severe hot flashes (Group S). Variables measured in this study included clinical parameters, hot flash experience, leukocytes, and fasting plasma levels of nine circulating cytokines/chemokines measured by using multiplex assays. Multiple linear regression analysis was used to evaluate the associations of hot flashes with these pro-inflammatory factors. Settings The study was performed in a hospital medical center. Results The mean values of leukocyte number were not different between these four groups. The hot flash status had a positive tendency toward increased levels of circulating IL-6 (P-trend = 0.049), IL-8 (P-trend < 0.001), TNF-α (P-trend = 0.008), and MIP1β (P-trend = 0.04). Multivariate linear regression analysis revealed that hot-flash severity was significantly associated with IL-8 (P-trend < 0.001) and TNFα (P-trend = 0.007) among these nine cytokines/chemokines after adjustment for age, menopausal duration, BMI and FSH. Multivariate analysis further revealed that severe hot flashes were strongly associated with a higher IL-8 (% difference, 37.19%; 95% confidence interval, 14.98,63.69; P < 0.001) and TNFα (51.27%; 6.64,114.57; P < 0.05). Conclusion The present study provides evidence that hot flashes are associated with circulating IL-8 and TNF-α in healthy postmenopausal women. It suggests that hot flashes might be related to low-grade systemic inflammation. PMID:28846735

  20. Fermi GBM Observations of Terrestrial Gamma Flashes

    NASA Technical Reports Server (NTRS)

    Wilson-Hodge, Colleen A.; Briggs, M. S.; Fishman, G. J.; Bhat, P. N.; Paciesas, W. S.; Preece, R.; Kippen, R. M.; von Kienlin, A.; Dwyer, J. R.; Smith, D. M.; hide

    2010-01-01

    In its first two years of operation, the Fermi Gamma Ray Burst Monitor (GBM) has observed more than 77 Terrestrial Gamma Flashes (TGFs). The thick Bismuth Germanate (BGO) detectors are excellent for TGF spectroscopy, having a high probability of recording the full energy of an incident photon, spanning a broad energy range from 150 keV to 40 MeV, and recording a large number of photons per TGF. Correlations between GBM TGF triggers and lightning sferics detected with the World-Wide Lightning Location Network indicate that TGFs and lightning are simultaneous to within tens of microseconds. The energy spectra of some TGFs have strong 511 keV positron annihilation lines, indicating that these TGFs contain a large fraction of positrons

  1. Fabrication of 94Zr thin target for recoil distance doppler shift method of lifetime measurement

    NASA Astrophysics Data System (ADS)

    Gupta, C. K.; Rohilla, Aman; Abhilash, S. R.; Kabiraj, D.; Singh, R. P.; Mehta, D.; Chamoli, S. K.

    2014-11-01

    A thin isotopic 94Zr target of thickness 520 μg /cm2 has been prepared for recoil distance Doppler shift method (RDM) lifetime measurement by using an electron beam deposition method on tantalum backing of 3.5 mg/cm2 thickness at Inter University Accelerator Center (IUAC), New Delhi. To meet the special requirement of smoothness of surface for RDM lifetime measurement and also to protect the outer layer of 94Zr from peeling off, a very thin layer of gold has been evaporated on a 94Zr target on a specially designed substrate holder. In all, 143 mg of 99.6% enriched 94Zr target material was utilized for the fabrication of 94Zr targets. The target has been successfully used in a recent RDM lifetime measurement experiment at IUAC.

  2. Discrimination of short-duration (two-pulse) flashes as a function of signal luminance and method of measurement.

    DOT National Transportation Integrated Search

    1971-11-01

    The recent introduction of strobe lights for anticollision purposes raises the possibility of using temporal patterns of short duration flashes as information carrying signals. The current experiments are concerned with the detection of the minimum d...

  3. Opacplot2: Enabling tabulated EoS and opacity compatibility for HEDLP simulations with the FLASH code

    NASA Astrophysics Data System (ADS)

    Laune, Jordan; Tzeferacos, Petros; Feister, Scott; Fatenejad, Milad; Yurchak, Roman; Flocke, Norbert; Weide, Klaus; Lamb, Donald

    2017-10-01

    Thermodynamic and opacity properties of materials are necessary to accurately simulate laser-driven laboratory experiments. Such data are compiled in tabular format since the thermodynamic range that needs to be covered cannot be described with one single theoretical model. Moreover, tabulated data can be made available prior to runtime, reducing both compute cost and code complexity. This approach is employed by the FLASH code. Equation of state (EoS) and opacity data comes in various formats, matrix-layouts, and file-structures. We discuss recent developments on opacplot2, an open-source Python module that manipulates tabulated EoS and opacity data. We present software that builds upon opacplot2 and enables easy-to-use conversion of different table formats into the IONMIX format, the native tabular input used by FLASH. Our work enables FLASH users to take advantage of a wider range of accurate EoS and opacity tables in simulating HELP experiments at the National Laser User Facilities.

  4. Is frictional heating needed to cause dramatic weakening of nanoparticle gouge during seismic slip? Insights from friction experiments with variable thermal evolutions

    NASA Astrophysics Data System (ADS)

    Yao, Lu; Ma, Shengli; Niemeijer, André R.; Shimamoto, Toshihiko; Platt, John D.

    2016-07-01

    To examine whether faults can be lubricated by preexisting and newly formed nanoparticles, we perform high-velocity friction experiments on periclase (MgO) nanoparticles and on bare surfaces of Carrara marble cylinders/slices, respectively. Variable temperature conditions were simulated by using host blocks of different thermal conductivities. When temperature rises are relatively low, we observe high friction in nano-MgO tests and unexpected slip strengthening following initial weakening in marble slice tests, suggesting that the dominant weakening mechanisms are of thermal origin. Solely the rolling of nanoparticles without significant temperature rise is insufficient to cause dynamic fault weakening. For nano-MgO experiments, comprehensive investigations suggest that flash heating is the most likely weakening mechanism. In marble experiments, flash heating controls the unique evolutions of friction, and the competition between bulk temperature rise and wear-induced changes of asperity contact numbers seems to strongly affect the efficiency of flash heating.

  5. Experimental approach to measure thick target neutron yields induced by heavy ions for shielding

    NASA Astrophysics Data System (ADS)

    Trinh, N. D.; Fadil, M.; Lewitowicz, M.; Brouillard, C.; Clerc, T.; Damoy, S.; Desmezières, V.; Dessay, E.; Dupuis, M.; Grinyer, G. F.; Grinyer, J.; Jacquot, B.; Ledoux, X.; Madeline, A.; Menard, N.; Michel, M.; Morel, V.; Porée, F.; Rannou, B.; Savalle, A.

    2017-09-01

    Double differential (angular and energy) neutron distributions were measured using an activation foil technique. Reactions were induced by impinging two low-energy heavy-ion beams accelerated with the GANIL CSS1 cyclotron: (36S (12 MeV/u) and 208Pb (6.25 MeV/u)) onto thick natCu targets. Results have been compared to Monte-Carlo calculations from two codes (PHITS and FLUKA) for the purpose of benchmarking radiation protection and shielding requirements. This comparison suggests a disagreement between calculations and experiment, particularly for high-energy neutrons.

  6. Fast neutron production from lithium converters and laser driven protons

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Storm, M.; Jiang, S.; Wertepny, D.

    2013-05-15

    Experiments to generate neutrons from the {sup 7}Li(p,n){sup 7}Be reaction with 60 J, 180 fs laser pulses have been performed at the Texas Petawatt Laser Facility at the University of Texas at Austin. The protons were accelerated from the rear surface of a thin target membrane using the target-normal-sheath-acceleration mechanism. The neutrons were generated in nuclear reactions caused by the subsequent proton bombardment of a pure lithium foil of natural isotopic abundance. The neutron energy ranged up to 2.9 MeV. The total yield was estimated to be 1.6 × 10{sup 7} neutrons per steradian. An extreme ultra-violet light camera, usedmore » to image the target rear surface, correlated variations in the proton yield and peak energy to target rear surface ablation. Calculations using the hydrodynamics code FLASH indicated that the ablation resulted from a laser pre-pulse of prolonged intensity. The ablation severely limited the proton acceleration and neutron yield.« less

  7. FLASH protects ZEB1 from degradation and supports cancer cells' epithelial-to-mesenchymal transition

    PubMed Central

    Abshire, C F; Carroll, J L; Dragoi, A-M

    2016-01-01

    Cancer metastasis remains a significant challenge and the leading cause of cancer-associated deaths. It is postulated that during metastasis cells undergo epithelial-to-mesenchymal transition (EMT), a process characterized by loss of cell–cell contacts and increased migratory and invasive potential. ZEB1 is one the most prominent transcriptional repressors of genes associated with EMT. We identified caspase-8-associated protein 2 (CASP8AP2 or FLASH) as a novel posttranscriptional regulator of ZEB1. Here we demonstrate that FLASH protects ZEB1 from proteasomal degradation brought by the action of the ubiquitin ligases SIAH1 and F-box protein FBXO45. As a result, loss of FLASH rapidly destabilized ZEB1 and reversed EMT cellular characteristics. Importantly, loss of FLASH blocked transforming growth factor-β-induced EMT and enhanced sensitivity to chemotherapy. Thus, we propose that FLASH–ZEB1 interplay may be a protective mechanism against ZEB1 degradation in cells undergoing EMT and may be an efficacious target for therapies aimed to block EMT progression. PMID:27526108

  8. Flash/crazing effects on simulator pursuit tracking performance

    NASA Astrophysics Data System (ADS)

    Stamper, D. A.; Lund, D. J.; Levine, R. R.; Molchany, J. W.; Best, P.

    1986-03-01

    Day sights which are purposefully or inadvertently irradiated with laser radiation may become nonfunctional due to cracking or crazing of the optical glass. The degree of performance degradation may be related to the amount of damage to the glass and possible flash blindness from reradiation. Thirty-two male enlisted men and officers tracked a scale model tank through a constant arc at a simulated distance of 1 km, using a laboratory constructed viscous-damped tracking device. There were four crazing groups (4 men/group) under bright and dim ambient light conditions for a total of eight groups. Each man tracked the target during three flash/crazing and three crazing only trials, which were randomly presented during 30 trials. The simulated countermeasure which included the flash and crazing had dramatic effects on tracking performance, even under daylight conditions. Under the most severe degree of crazing, tracking performance was not possible under either ambient light condition. The relatively small amounts of laser radiation used to craze the BK-7 glass used in this study, which lead to significant performance decrements, demonstrates the potential impact of flash/crazing effects on operators of day sights.

  9. A conserved interaction that is essential for the biogenesis of histone locus bodies.

    PubMed

    Yang, Xiao-cui; Sabath, Ivan; Kunduru, Lalitha; van Wijnen, Andre J; Marzluff, William F; Dominski, Zbigniew

    2014-12-05

    Nuclear protein, ataxia-telangiectasia locus (NPAT) and FLICE-associated huge protein (FLASH) are two major components of discrete nuclear structures called histone locus bodies (HLBs). NPAT is a key co-activator of histone gene transcription, whereas FLASH through its N-terminal region functions in 3' end processing of histone primary transcripts. The C-terminal region of FLASH contains a highly conserved domain that is also present at the end of Yin Yang 1-associated protein-related protein (YARP) and its Drosophila homologue, Mute, previously shown to localize to HLBs in Drosophila cells. Here, we show that the C-terminal domain of human FLASH and YARP interacts with the C-terminal region of NPAT and that this interaction is essential and sufficient to drive FLASH and YARP to HLBs in HeLa cells. Strikingly, only the last 16 amino acids of NPAT are sufficient for the interaction. We also show that the C-terminal domain of Mute interacts with a short region at the end of the Drosophila NPAT orthologue, multi sex combs (Mxc). Altogether, our data indicate that the conserved C-terminal domain shared by FLASH, YARP, and Mute recognizes the C-terminal sequence of NPAT orthologues, thus acting as a signal targeting proteins to HLBs. Finally, we demonstrate that the C-terminal domain of human FLASH can be directly joined with its N-terminal region through alternative splicing. The resulting 190-amino acid MiniFLASH, despite lacking 90% of full-length FLASH, contains all regions necessary for 3' end processing of histone pre-mRNA in vitro and accumulates in HLBs. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

  10. Shapes displayed with durations in the microsecond range do not obey Bloch's law of temporal summation

    PubMed Central

    Greene, Ernest; Ogden, R. Todd

    2013-01-01

    Shape patterns were displayed with simultaneous brief flashes from a light-emitting diode array. Flash durations in the microsecond range and luminous intensities were adjusted to vary the degree of successful shape recognition. Four experiments were conducted to test whether Bloch's law would apply in this task. Bloch's law holds that for very brief flashes the perceptual threshold is determined by the total number of photons being delivered, i.e., there is reciprocity of intensity and duration. The present results did not find that effectiveness of flashes was based on the total quantity of photons, as predicted by Bloch's law. Additionally, the evidence points to a visual mechanism that has ultra-high temporal precision that either registers the rate of photon flux or the duration of flashes. PMID:24349700

  11. a Plutonium Ceramic Target for Masha

    NASA Astrophysics Data System (ADS)

    Wilk, P. A.; Shaughnessy, D. A.; Moody, K. J.; Kenneally, J. M.; Wild, J. F.; Stoyer, M. A.; Patin, J. B.; Lougheed, R. W.; Ebbinghaus, B. B.; Landingham, R. L.; Oganessian, Yu. Ts.; Yeremin, A. V.; Dmitriev, S. N.

    2005-09-01

    We are currently developing a plutonium ceramic target for the MASHA mass separator. The MASHA separator will use a thick plutonium ceramic target capable of tolerating temperatures up to 2000 °C. Promising candidates for the target include oxides and carbides, although more research into their thermodynamic properties will be required. Reaction products will diffuse out of the target into an ion source, where they will then be transported through the separator to a position-sensitive focal-plane detector array. Experiments on MASHA will allow us to make measurements that will cement our identification of element 114 and provide for future experiments where the chemical properties of the heaviest elements are studied.

  12. Role of Cerenkov radiation in the eye-flashes observed by Apollo astronauts.

    PubMed

    McNulty, P J; Pease, V P; Bond, V P

    1976-01-01

    Visual phenomena in the form of colorless flashes of light were observed by astronauts in deep space when their eyes were closed and adapted to darkness. We describe in this paper laboratory experiments and calculations which indicate that many of these flashes are the result of visible light generated within the astronauts' eyeball in the form of Cerenkov radiation when a relativistic HZE particle traverses it. The sensitivity to Cerenkov radiation measured for three subjects exposed to pulses of pions and muons and the visual phenomena observed were found to be consistent with the reports of flashes observed at rates as high as 2 per minute on Apollo missions 11 through 17.

  13. A SONOS device with a separated charge trapping layer for improvement of charge injection

    NASA Astrophysics Data System (ADS)

    Ahn, Jae-Hyuk; Moon, Dong-Il; Ko, Seung-Won; Kim, Chang-Hoon; Kim, Jee-Yeon; Kim, Moon-Seok; Seol, Myeong-Lok; Moon, Joon-Bae; Choi, Ji-Min; Oh, Jae-Sub; Choi, Sung-Jin; Choi, Yang-Kyu

    2017-03-01

    A charge trapping layer that is separated from the primary gate dielectric is implemented on a FinFET SONOS structure. By virtue of the reduced effective oxide thickness of the primary gate dielectric, a strong gate-to-channel coupling is obtained and thus short-channel effects in the proposed device are effectively suppressed. Moreover, a high program/erase speed and a large shift in the threshold voltage are achieved due to the improved charge injection by the reduced effective oxide thickness. The proposed structure has potential for use in high speed flash memory.

  14. Circulating leptin and adiponectin are associated with insulin resistance in healthy postmenopausal women with hot flashes.

    PubMed

    Huang, Wan-Yu; Chang, Chia-Chu; Chen, Dar-Ren; Kor, Chew-Teng; Chen, Ting-Yu; Wu, Hung-Ming

    2017-01-01

    Hot flashes have been postulated to be linked to the development of metabolic disorders. This study aimed to evaluate the relationship between hot flashes, adipocyte-derived hormones, and insulin resistance in healthy, non-obese postmenopausal women. In this cross-sectional study, a total of 151 women aged 45-60 years were stratified into one of three groups according to hot-flash status over the past three months: never experienced hot flashes (Group N), mild-to-moderate hot flashes (Group M), and severe hot flashes (Group S). Variables measured in this study included clinical parameters, hot flash experience, fasting levels of circulating glucose, lipid profiles, plasma insulin, and adipocyte-derived hormones. Multiple linear regression analysis was used to evaluate the associations of hot flashes with adipocyte-derived hormones, and with insulin resistance. The study was performed in a hospital medical center. The mean (standard deviation) of body-mass index was 22.8(2.7) for Group N, 22.6(2.6) for Group M, and 23.5(2.4) for Group S, respectively. Women in Group S displayed statistically significantly higher levels of leptin, fasting glucose, and insulin, and lower levels of adiponectin than those in Groups M and N. Multivariate linear regression analysis revealed that hot-flash severity was significantly associated with higher leptin levels, lower adiponectin levels, and higher leptin-to-adiponectin ratio. Univariate linear regression analysis revealed that hot-flash severity was strongly associated with a higher HOMA-IR index (% difference, 58.03%; 95% confidence interval, 31.00-90.64; p < 0.001). The association between hot flashes and HOMA-IR index was attenuated after adjusting for leptin or adiponectin and was no longer significant after simultaneously adjusting for leptin and adiponectin. The present study provides evidence that hot flashes are associated with insulin resistance in postmenopausal women. It further suggests that hot flash association with insulin resistance is dependent on the combination of leptin and adiponectin variables.

  15. Extracting a mix parameter from 2D radiography of variable density flow

    NASA Astrophysics Data System (ADS)

    Kurien, Susan; Doss, Forrest; Livescu, Daniel

    2017-11-01

    A methodology is presented for extracting quantities related to the statistical description of the mixing state from the 2D radiographic image of a flow. X-ray attenuation through a target flow is given by the Beer-Lambert law which exponentially damps the incident beam intensity by a factor proportional to the density, opacity and thickness of the target. By making reasonable assumptions for the mean density, opacity and effective thickness of the target flow, we estimate the contribution of density fluctuations to the attenuation. The fluctuations thus inferred may be used to form the correlation of density and specific-volume, averaged across the thickness of the flow in the direction of the beam. This correlation function, denoted by b in RANS modeling, quantifies turbulent mixing in variable density flows. The scheme is tested using DNS data computed for variable-density buoyancy-driven mixing. We quantify the deficits in the extracted value of b due to target thickness, Atwood number, and modeled noise in the incident beam. This analysis corroborates the proposed scheme to infer the mix parameter from thin targets at moderate to low Atwood numbers. The scheme is then applied to an image of counter-shear flow obtained from experiments at the National Ignition Facility. US Department of Energy.

  16. Liquid crystal films as on-demand, variable thickness (50–5000 nm) targets for intense lasers

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Poole, P. L., E-mail: poole.134@osu.edu; Andereck, C. D.; Schumacher, D. W.

    2014-06-15

    We have developed a new type of target for intense laser-matter experiments that offers significant advantages over those currently in use. The targets consist of a liquid crystal film freely suspended within a metal frame. They can be formed rapidly on-demand with thicknesses ranging from nanometers to micrometers, where the particular value is determined by the liquid crystal temperature and initial volume as well as by the frame geometry. The liquid crystal used for this work, 8CB (4′-octyl-4-cyanobiphenyl), has a vapor pressure below 10{sup −6} Torr, so films made at atmospheric pressure maintain their initial thickness after pumping to high vacuum.more » Additionally, the volume per film is such that each target costs significantly less than one cent to produce. The mechanism of film formation and relevant physics of liquid crystals are described, as well as ion acceleration data from the first shots on liquid crystal film targets at the Ohio State University Scarlet laser facility.« less

  17. Spark Generated by ChemCam Laser During Tests

    NASA Image and Video Library

    2010-09-21

    The ChemCam instrument for NASA Mars Science Laboratory mission uses a pulsed laser beam to vaporize a pinhead-size target, producing a flash of light from the ionized material plasma that can be analyzed to identify chemical elements in the target.

  18. Do the flash-lag effect and representational momentum involve similar extrapolations?

    PubMed Central

    Hubbard, Timothy L.

    2013-01-01

    In the flash-lag effect (FLE) and in representational momentum (RM), the represented position of a moving target is displaced in the direction of motion. Effects of numerous variables on the FLE and on RM are briefly considered. In many cases, variables appear to have the same effect on the FLE and on RM, and this is consistent with a hypothesis that displacements in the FLE and in RM result from overlapping or similar mechanisms. In other cases, variables initially appear to have different effects on the FLE and on RM, but accounts reconciling those apparent differences with a hypothesis of overlapping or similar mechanisms are suggested. Given that RM is simpler and accounts for a wider range of findings (i.e., RM involves a single stimulus rather than the relationship between two stimuli, RM accounts for displacement in absolute position of a single stimulus and for differences in relative position of two stimuli), it is suggested that (at least some cases of) the FLE might be a special case of RM in which the position of the target is assessed relative to the position of another stimulus (i.e., the flashed object) rather than relative to the actual position of the target. PMID:23734140

  19. Evaluating Non-In-Place Update Techniques for Flash-Based Transaction Processing Systems

    NASA Astrophysics Data System (ADS)

    Wang, Yongkun; Goda, Kazuo; Kitsuregawa, Masaru

    Recently, flash memory is emerging as the storage device. With price sliding fast, the cost per capacity is approaching to that of SATA disk drives. So far flash memory has been widely deployed in consumer electronics even partly in mobile computing environments. For enterprise systems, the deployment has been studied by many researchers and developers. In terms of the access performance characteristics, flash memory is quite different from disk drives. Without the mechanical components, flash memory has very high random read performance, whereas it has a limited random write performance because of the erase-before-write design. The random write performance of flash memory is comparable with or even worse than that of disk drives. Due to such a performance asymmetry, naive deployment to enterprise systems may not exploit the potential performance of flash memory at full blast. This paper studies the effectiveness of using non-in-place-update (NIPU) techniques through the IO path of flash-based transaction processing systems. Our deliberate experiments using both open-source DBMS and commercial DBMS validated the potential benefits; x3.0 to x6.6 performance improvement was confirmed by incorporating non-in-place-update techniques into file system without any modification of applications or storage devices.

  20. TRAC based sensing for autonomous rendezvous

    NASA Technical Reports Server (NTRS)

    Everett, Louis J.; Monford, Leo

    1991-01-01

    The Targeting Reflective Alignment Concept (TRAC) sensor is to be used in an effort to support an Autonomous Rendezvous and Docking (AR&D) flight experiment. The TRAC sensor uses a fixed-focus, fixed-iris CCD camera and a target that is a combination of active and passive components. The system experiment is anticipated to fly in 1994 using two Commercial Experiment Transporters (COMET's). The requirements for the sensor are: bearing error less than or equal to 0.075 deg; bearing error rate less than 0.3 deg/sec; attitude error less than 0.5 deg.; and attitude rate error less than 2.0 deg/sec. The range requirement depends on the range and the range rate of the vehicle. The active component of the target is several 'kilo-bright' LED's that can emit 2500 millicandela with 40 milliwatts of input power. Flashing the lights in a known pattern eliminates background illumination. The system should be able to rendezvous from 300 meters all the way to capture. A question that arose during the presentation: What is the life time of the LED's and their sensitivity to radiation? The LED's should be manufactured to Military Specifications, coated with silicon dioxide, and all other space qualified precautions should be taken. The LED's will not be on all the time so they should easily last the two-year mission.

  1. Optimal proximity correction: application for flash memory design

    NASA Astrophysics Data System (ADS)

    Chen, Y. O.; Huang, D. L.; Sung, K. T.; Chiang, J. J.; Yu, M.; Teng, F.; Chu, Lung; Rey, Juan C.; Bernard, Douglas A.; Li, Jiangwei; Li, Junling; Moroz, V.; Boksha, Victor V.

    1998-06-01

    Proximity Correction is the technology for which the most of IC manufacturers are committed already. The final intended result of correction is affected by many factors other than the optical characteristics of the mask-stepper system, such as photoresist exposure, post-exposure bake and development parameters, etch selectivity and anisotropy, and underlying topography. The most advanced industry and research groups already reported immediate need to consider wafer topography as one of the major components during a Proximity Correction procedure. In the present work we are discussing the corners rounding effect (which eventually cause electrical leakage) observed for the elements of Poly2 layer for a Flash Memory Design. It was found that the rounding originated by three- dimensional effects due to variation of photoresist thickness resulting from the non-planar substrate. Our major goal was to understand the reasons and correct corner rounding. As a result of this work highly effective layout correction methodology was demonstrated and manufacturable Depth Of Focus was achieved. Another purpose of the work was to demonstrate complete integration flow for a Flash Memory Design based on photolithography; deposition/etch; ion implantation/oxidation/diffusion; and device simulators.

  2. Supernova shock breakout through a wind

    NASA Astrophysics Data System (ADS)

    Balberg, Shmuel; Loeb, Abraham

    2011-06-01

    The breakout of a supernova shock wave through the progenitor star's outer envelope is expected to appear as an X-ray flash. However, if the supernova explodes inside an optically thick wind, the breakout flash is delayed. We present a simple model for estimating the conditions at shock breakout in a wind based on the general observable quantities in the X-ray flash light curve; the total energy EX, and the diffusion time after the peak, tdiff. We base the derivation on the self-similar solution for the forward-reverse shock structure expected for an ejecta plowing through a pre-existing wind at large distances from the progenitor's surface. We find simple quantitative relations for the shock radius and velocity at breakout. By relating the ejecta density profile to the pre-explosion structure of the progenitor, the model can also be extended to constrain the combination of explosion energy and ejecta mass. For the observed case of XRO08109/SN2008D, our model provides reasonable constraints on the breakout radius, explosion energy and ejecta mass, and predicts a high shock velocity which naturally accounts for the observed non-thermal spectrum.

  3. Collecting Response Times using Amazon Mechanical Turk and Adobe Flash

    PubMed Central

    Simcox, Travis; Fiez, Julie A.

    2017-01-01

    Crowdsourcing systems like Amazon's Mechanical Turk (AMT) allow data to be collected from a large sample of people in a short amount of time. This use has garnered considerable interest from behavioral scientists. So far, most experiments conducted on AMT have focused on survey-type instruments because of difficulties inherent in running many experimental paradigms over the Internet. This article investigated the viability of presenting stimuli and collecting response times using Adobe Flash to run ActionScript 3 code in conjunction with AMT. First, the timing properties of Adobe Flash were investigated using a phototransistor and two desktop computers running under several conditions mimicking those that may be present in research using AMT. This experiment revealed some strengths and weaknesses of the timing capabilities of this method. Next, a flanker task and a lexical decision task implemented in Adobe Flash were administered to participants recruited with AMT. The expected effects in these tasks were replicated. Power analyses were conducted to describe the number of participants needed to replicate these effects. A questionnaire was used to investigate previously undescribed computer use habits of 100 participants on AMT. We conclude that a Flash program in conjunction with AMT can be successfully used for running many experimental paradigms that rely on response times, although experimenters must understand the limitations of the method. PMID:23670340

  4. Fast-moving dislocations trigger flash weakening in carbonate-bearing faults during earthquakes

    PubMed Central

    Spagnuolo, Elena; Plümper, Oliver; Violay, Marie; Cavallo, Andrea; Di Toro, Giulio

    2015-01-01

    Rupture fronts can cause fault displacement, reaching speeds up to several ms−1 within a few milliseconds, at any distance away from the earthquake nucleation area. In the case of silicate-bearing rocks the abrupt slip acceleration results in melting at asperity contacts causing a large reduction in fault frictional strength (i.e., flash weakening). Flash weakening is also observed in experiments performed in carbonate-bearing rocks but evidence for melting is lacking. To unravel the micro-physical mechanisms associated with flash weakening in carbonates, experiments were conducted on pre-cut Carrara marble cylinders using a rotary shear apparatus at conditions relevant to earthquakes propagation. In the first 5 mm of slip the shear stress was reduced up to 30% and CO2 was released. Focused ion beam, scanning and transmission electron microscopy investigations of the slipping zones reveal the presence of calcite nanograins and amorphous carbon. We interpret the CO2 release, the formation of nanograins and amorphous carbon to be the result of a shock-like stress release associated with the migration of fast-moving dislocations. Amorphous carbon, given its low friction coefficient, is responsible for flash weakening and promotes the propagation of the seismic rupture in carbonate-bearing fault patches. PMID:26552964

  5. The Flash ADC system and PMT waveform reconstruction for the Daya Bay experiment

    NASA Astrophysics Data System (ADS)

    Huang, Yongbo; Chang, Jinfan; Cheng, Yaping; Chen, Zhang; Hu, Jun; Ji, Xiaolu; Li, Fei; Li, Jin; Li, Qiuju; Qian, Xin; Jetter, Soeren; Wang, Wei; Wang, Zheng; Xu, Yu; Yu, Zeyuan

    2018-07-01

    To better understand the energy response of the Antineutrino Detector (AD), the Daya Bay Reactor Neutrino Experiment installed a full Flash ADC readout system on one AD that allowed for simultaneous data taking with the current readout system. This paper presents the design, data acquisition, and simulation of the Flash ADC system, and focuses on the PMT waveform reconstruction algorithms. For liquid scintillator calorimetry, the most critical requirement to waveform reconstruction is linearity. Several common reconstruction methods were tested but the linearity performance was not satisfactory. A new method based on the deconvolution technique was developed with 1% residual non-linearity, which fulfills the requirement. The performance was validated with both data and Monte Carlo (MC) simulations, and 1% consistency between them has been achieved.

  6. ``Flash'' synthesis of ``giant'' Mn-doped CdS/ZnSe/ZnS nanocrystals with ZnSe layer as hole quantum-well

    NASA Astrophysics Data System (ADS)

    Xu, Ruilin; Zhang, Jiayu

    Usually, exciton-Mn energy transfer in Mn-doped CdS/ZnS nanocrystals (NCs) can readily outcompete the exciton trapping by an order of magnitude. However, with the accumulation of non-radiative defects in the giant shell during the rapid growth of the thick shell (up to ~20 monolayers in no more than 10 minutes), the photoluminescence (PL) quantum yield of this kind of ``giant'' NCs is significantly reduced by the accumulation of non-radiative defects during the rapid growth of thick shell. That is because the exciton-Mn energy transfer in Mn-doped CdS/ZnS NCs is significantly inhibited by the hole trapping as the major competing process, resulting from the insufficient hole-confinement in CdS/ZnS NCs. Accordingly ``flash'' synthesis of giant Mn-doped CdS/ZnSe/ZnS NCs with ZnSe layer as hole quantum-well is developed to suppress the inhibition. Meanwhile Mn2+ PL peak changes profoundly from ~620 nm to ~540 nm after addition of ZnSe layer. Studies are under the way to explore the relevant mechanisms.

  7. A Self-consistent Model for a Full Cycle of Recurrent Novae—Wind Mass-loss Rate and X-Ray Luminosity

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kato, Mariko; Saio, Hideyuki; Hachisu, Izumi, E-mail: mariko.kato@hc.st.keio.ac.jp

    2017-04-01

    An unexpectedly slow evolution in the pre-optical-maximum phase was suggested in the very short recurrence period of nova M31N 2008-12a. To obtain reasonable nova light curves we have improved our calculation method by consistently combining optically thick wind solutions of hydrogen-rich envelopes with white dwarf (WD) structures calculated by a Henyey-type evolution code. The wind mass-loss rate is properly determined with high accuracy. We have calculated light curve models for 1.2 M {sub ⊙} and 1.38 M {sub ⊙} WDs with mass accretion rates corresponding to recurrence periods of 10 yr and 1 yr, respectively. The outburst lasts 590/29 days,more » in which the pre-optical-maximum phase is 82/16 days, for 1.2/1.38 M {sub ⊙}, respectively. Optically thick winds start at the end of the X-ray flash and cease at the beginning of the supersoft X-ray phase. We also present supersoft X-ray light curves including a prompt X-ray flash and later supersoft X-ray phase.« less

  8. Structural characterization and gas reactions of small metal particles by high-resolution TEM and TED

    NASA Technical Reports Server (NTRS)

    Heinemann, K.

    1985-01-01

    The interaction of 100 and 200 keV electron beams with amorphous alumina, titania, and aluminum nitride substrates and nanometer-size palladium particulate deposits was investigated for the two extreme cases of (1) large-area electron-beam flash-heating and (2) small-area high-intensity electron-beam irradiation. The former simulates a short-term heating effect with minimum electron irradiation exposure, the latter simulates high-dosage irradiation with minimum heating effect. All alumina and titania samples responded to the flash-heating treatment with significant recrystallization. However, the size, crystal structure, shape, and orientation of the grains depended on the type and thickness of the films and the thickness of the Pd deposit. High-dosage electron irradiation also readily crystallized the alumina substrate films but did not affect the titania films. The alumina recrystallization products were usually either all in the alpha phase, or they were a mixture of small grains in a number of low-temperature phases including gamma, delta, kappa, beta, theta-alumina. Palladium deposits reacted heavily with the alumina substrates during either treatment, but they were very little effected when supported on titania. Both treatments had the same, less prominent localized crystallization effect on aluminum nitride films.

  9. Experimental Test of Spatial Updating Models for Monkey Eye-Head Gaze Shifts

    PubMed Central

    Van Grootel, Tom J.; Van der Willigen, Robert F.; Van Opstal, A. John

    2012-01-01

    How the brain maintains an accurate and stable representation of visual target locations despite the occurrence of saccadic gaze shifts is a classical problem in oculomotor research. Here we test and dissociate the predictions of different conceptual models for head-unrestrained gaze-localization behavior of macaque monkeys. We adopted the double-step paradigm with rapid eye-head gaze shifts to measure localization accuracy in response to flashed visual stimuli in darkness. We presented the second target flash either before (static), or during (dynamic) the first gaze displacement. In the dynamic case the brief visual flash induced a small retinal streak of up to about 20 deg at an unpredictable moment and retinal location during the eye-head gaze shift, which provides serious challenges for the gaze-control system. However, for both stimulus conditions, monkeys localized the flashed targets with accurate gaze shifts, which rules out several models of visuomotor control. First, these findings exclude the possibility that gaze-shift programming relies on retinal inputs only. Instead, they support the notion that accurate eye-head motor feedback updates the gaze-saccade coordinates. Second, in dynamic trials the visuomotor system cannot rely on the coordinates of the planned first eye-head saccade either, which rules out remapping on the basis of a predictive corollary gaze-displacement signal. Finally, because gaze-related head movements were also goal-directed, requiring continuous access to eye-in-head position, we propose that our results best support a dynamic feedback scheme for spatial updating in which visuomotor control incorporates accurate signals about instantaneous eye- and head positions rather than relative eye- and head displacements. PMID:23118883

  10. ANXIETY AS A RISK FACTOR FOR MENOPAUSAL HOT FLASHES: EVIDENCE FROM THE PENN OVARIAN AGING COHORT

    PubMed Central

    Freeman, Ellen W.; Sammel, Mary D.

    2016-01-01

    Objective The aim of this study was to identify temporal associations of anxiety dimensions with menopausal hot flashes in women progressing through the menopause transition. We hypothesized that associations of both somatic and affective dimensions of anxiety with hot flashes increased in the menopause transition, and that somatic anxiety was an independent risk factor for menopausal hot flashes. Methods Hot flashes, anxiety symptoms, hormone levels and other psychosocial variables were assessed annually for 14 years of follow-up. The 233 women were premenopausal at baseline and continued through one year or more after the final menstrual period. Anxiety dimensions were assessed with the Zung Anxiety Scale (ZAS), a validated measure of affective anxiety and somatic anxiety. Summed item scores were divided by the number of items rated, so that ranges of the two dimensions were comparable. Results Seventy-two percent of the sample reported moderate/severe hot flashes during the 14-year interval. There was no significant interaction between anxiety dimensions and menopausal stages. However, when adjusted for menopausal stage, the magnitude of association between somatic anxiety and hot flashes dramatically increased (OR 3.03, 95% CI: 2.12, 4.32, P<0.001), while the association between affective anxiety and hot flashes increased to a lesser extent (OR 1.27, 95% CI: 1.03, 1.57, P=0.024). Women with high levels of somatic anxiety (top third of the sample) had the greatest risk of hot flashes (P<0.001). When the anxiety dimensions were considered in combination, the additive effect of high affective anxiety symptoms was minimal, with no significant difference between the group with high affective/low somatic symptoms and the low symptom group in incident hot flashes at each menopausal stage (P=0.54). In multivariable analysis, somatic anxiety increased the risk of hot flashes more than 3 times (OR 3.13, 95% CI: 2.16, 4.53, P<0.001), but affective anxiety was not significantly associated with hot flashes after adjustment for other study variables (OR 1.19, 95% CI: 0.96, 1.48, P=0.117). Time-lagged somatic anxiety scores significantly predicted hot flashes, with a 71% increase in risk (OR 1.71, 95% CI: 1.21, 2.41, P=0.002). Time-lagged affective anxiety scores did not predict hot flashes, (OR 1.06, 95% CI: 0.87, 1.31, P=0.58). Conclusions This study showed a strong predictive association of somatic anxiety with the risk of menopausal hot flashes. The temporal associations suggest that somatic anxiety is not simply a redundant measure of hot flashes but predicts the risk of menopausal hot flashes and may be a potential target in clinical management of perimenopausal women. PMID:27433864

  11. Total Lightning and Radar Storm Characteristics Associated with Severe Storms in Central Florida

    NASA Technical Reports Server (NTRS)

    Goodman, Steven J; Raghavan, R.; Buechler, Dennis; Hodanish, S.; Sharp, D.; Williams, E.; Boldi, B.; Matlin, A.; Weber, M.

    1998-01-01

    This paper examines the three dimensional characteristics of lightning flashes and severe storms observed in Central Florida during 1997-1998. The lightning time history of severe and tornadic storms were captured during the on-going ground validation campaign supporting the Lightning Imaging Sensor (LIS) experiment on the Tropical Rainfall Measuring Mission (TRMM). The ground validation campaign is a collaborative experiment that began in 1997 and involves scientists at the Global Hydrology and Climate Center, MIT/Lincoln Laboratories, and the NWS Forecast Office at Melbourne, FL. Lightning signatures that may provide potential early warning of severe storms are being evaluated by the forecasters at the NWS/MLB office. Severe storms with extreme flash rates sometimes exceeding 300 per minute and accompanying rapid increases in flash rate prior to the onset of the severe weather (hall, damaging winds, tornadoes) have been reported by Hodanish et al. and Williams et al. (1998-this conference). We examine the co-evolving changes in storm structure (mass, echo top, shear, latent heat release) and kinematics associated with these extreme and rapid flash rate changes over time. The flash frequency and density are compared with the three dimensional radar reflectivity structure of the storm to help interpret the possible mechanisms producing the extreme and rapidly increasing flash rates. For two tornadic storms examined thus far, we find the burst of lightning is associated with the development of upper level rotation in the storm. In one case, the lightning burst follows the formation of a bounded weak echo region (BWER). The flash rates diminish with time as the rotation develops to the ground in conjunction with the decent of the reflectivity core. Our initial findings suggest the dramatic increase of flash rates is associated with a sudden and dramatic increase in storm updraft intensity which we hypothesize is stretching vertical vorticity as well as enhancing the development of the mixed phase region of the storm. We discuss the importance of these factors in producing both the observed extreme flash rates and the severe weather that follows in these storms and others to be presented.

  12. Viewing Spark Generated by ChemCam Laser for Mars Rover

    NASA Image and Video Library

    2010-09-21

    The ChemCam instrument for NASA Mars Science Laboratory mission uses a pulsed laser beam to vaporize a pinhead-size target, producing a flash of light from the ionized material plasma that can be analyzed to identify chemical elements in the target.

  13. EEG character identification using stimulus sequences designed to maximize mimimal hamming distance.

    PubMed

    Fukami, Tadanori; Shimada, Takamasa; Forney, Elliott; Anderson, Charles W

    2012-01-01

    In this study, we have improved upon the P300 speller Brain-Computer Interface paradigm by introducing a new character encoding method. Our concept in detection of the intended character is not based on a classification of target and nontarget responses, but based on an identifaction of the character which maximize the difference between P300 amplitudes in target and nontarget stimuli. Each bit included in the code corresponds to flashing character, '1', and non-flashing, '0'. Here, the codes were constructed in order to maximize the minimum hamming distance between the characters. Electroencephalography was used to identify the characters using a waveform calculated by adding and subtracting the response of the target and non-target stimulus according the codes respectively. This stimulus presentation method was applied to a 3×3 character matrix, and the results were compared with that of a conventional P300 speller of the same size. Our method reduced the time until the correct character was obtained by 24%.

  14. Risk of long-term hot flashes after natural menopause: evidence from the Penn Ovarian Aging Study cohort.

    PubMed

    Freeman, Ellen W; Sammel, Mary D; Sanders, Richard J

    2014-09-01

    This study aims to estimate the risk of hot flashes relative to natural menopause and to evaluate the associations of hormone levels, behavioral variables, and demographic variables with the risk of hot flashes after menopause. We performed annual assessment of 255 women who were premenopausal at baseline and reached natural menopause within 16 years of follow-up. The prevalence of moderate/severe hot flashes increased in each premenopausal year, reaching a peak of 46% in the first 2 years after the final menstrual period (FMP). Hot flashes decreased slowly after menopause and did not return to premenopausal levels until 9 years after the FMP. The mean (SD) duration of moderate/severe hot flashes after the FMP was 4.6 (2.9) years (for any hot flashes, 4.9 [3.1] y). One third of women at 10 years or more after menopause continued to experience moderate/severe hot flashes. African-American women (obese and nonobese) and obese white women had significantly greater risks of hot flashes compared with nonobese white women (interaction, P = 0.01). In multivariable analysis, increasing follicle-stimulating hormone levels before the FMP (P < 0.001), decreasing estradiol (odds ratio, 0.87; 95% CI, 0.78-0.96; P = 0.008), and increasing anxiety (odds ratio, 1.05; 95% CI, 1.03-1.06; P < 0.001) were significant risk factors for hot flashes, whereas higher education levels were protective (odds ratio, 0.66; 95% CI, 0.47-0.91; P = 0.011). Moderate/severe hot flashes continue, on average, for nearly 5 years after menopause; more than one third of women observed for 10 years or more after menopause have moderate/severe hot flashes. Continuation of hot flashes for more than 5 years after menopause underscores the importance of determining individual risks/benefits when selecting hormone or nonhormone therapy for menopausal symptoms.

  15. RISK OF LONG TERM HOT FLASHES AFTER NATURAL MENOPAUSE: EVIDENCE FROM THE PENN OVARIAN AGING COHORT

    PubMed Central

    Freeman, Ellen W.; Sammel, Mary D.; Sanders, Richard J.

    2015-01-01

    Objectives To estimate the risk of hot flashes relative to natural menopause and evaluate associations of hormone levels, behavioral and demographic variables with the risk of hot flashes following menopause. Methods Annual assessments of 255 women who were premenopausal at baseline and reached natural menopause during 16 years of follow-up. Results The prevalence of moderate/severe hot flashes increased in each premenopausal year, reaching a peak of 46% in the first two years after the final menstrual period (FMP). Hot flashes decreased slowly following menopause and did not return to premenopausal levels until 9 years after FMP. The mean duration of moderate/severe hot flashes after FMP was 4.6 (SD2.9) years (4.9, SD3.1 years for any hot flashes). One-third of women at 10 or more years following menopause continued to experience moderate/severe hot flashes. African American women (obese and non-obese) and obese white women had significantly greater risk of hot flashes compared to non-obese white women (interaction P=0.01). In multivariable analysis, increasing FSH levels before FMP (P<0.001), decreasing estradiol (OR 0.87, 95% CI: 0.78–0.96, P=0.008), and increasing anxiety (OR 1.05, 95% CI: 1.03–1.06, P<0.001) were significant risk factors for hot flashes, while higher education levels were protective (OR 0.66, 95% CI: 0.47–0.91, P=0.011). Conclusions Moderate/severe hot flashes continued on average for nearly 5 years following menopause; more than one- third of women observed for 10 or more years following menopause had moderate/severe hot flashes. Continuation of hot flashes for more than 5 years following menopause underscores the importance of determining individual risk/benefit when selecting hormone or non-hormonal therapy for menopausal symptoms. PMID:24473530

  16. Effect with high density nano dot type storage layer structure on 20 nm planar NAND flash memory characteristics

    NASA Astrophysics Data System (ADS)

    Sasaki, Takeshi; Muraguchi, Masakazu; Seo, Moon-Sik; Park, Sung-kye; Endoh, Tetsuo

    2014-01-01

    The merits, concerns and design principle for the future nano dot (ND) type NAND flash memory cell are clarified, by considering the effect of storage layer structure on NAND flash memory characteristics. The characteristics of the ND cell for a NAND flash memory in comparison with the floating gate type (FG) is comprehensively studied through the read, erase, program operation, and the cell to cell interference with device simulation. Although the degradation of the read throughput (0.7% reduction of the cell current) and slower program time (26% smaller programmed threshold voltage shift) with high density (10 × 1012 cm-2) ND NAND are still concerned, the suppress of the cell to cell interference with high density (10 × 1012 cm-2) plays the most important part for scaling and multi-level cell (MLC) operation in comparison with the FG NAND. From these results, the design knowledge is shown to require the control of the number of nano dots rather than the higher nano dot density, from the viewpoint of increasing its memory capacity by MLC operation and suppressing threshold voltage variability caused by the number of dots in the storage layer. Moreover, in order to increase its memory capacity, it is shown the tunnel oxide thickness with ND should be designed thicker (>3 nm) than conventional designed ND cell for programming/erasing with direct tunneling mechanism.

  17. Musicians have enhanced audiovisual multisensory binding: experience-dependent effects in the double-flash illusion.

    PubMed

    Bidelman, Gavin M

    2016-10-01

    Musical training is associated with behavioral and neurophysiological enhancements in auditory processing for both musical and nonmusical sounds (e.g., speech). Yet, whether the benefits of musicianship extend beyond enhancements to auditory-specific skills and impact multisensory (e.g., audiovisual) processing has yet to be fully validated. Here, we investigated multisensory integration of auditory and visual information in musicians and nonmusicians using a double-flash illusion, whereby the presentation of multiple auditory stimuli (beeps) concurrent with a single visual object (flash) induces an illusory perception of multiple flashes. We parametrically varied the onset asynchrony between auditory and visual events (leads and lags of ±300 ms) to quantify participants' "temporal window" of integration, i.e., stimuli in which auditory and visual cues were fused into a single percept. Results show that musically trained individuals were both faster and more accurate at processing concurrent audiovisual cues than their nonmusician peers; nonmusicians had a higher susceptibility for responding to audiovisual illusions and perceived double flashes over an extended range of onset asynchronies compared to trained musicians. Moreover, temporal window estimates indicated that musicians' windows (<100 ms) were ~2-3× shorter than nonmusicians' (~200 ms), suggesting more refined multisensory integration and audiovisual binding. Collectively, findings indicate a more refined binding of auditory and visual cues in musically trained individuals. We conclude that experience-dependent plasticity of intensive musical experience extends beyond simple listening skills, improving multimodal processing and the integration of multiple sensory systems in a domain-general manner.

  18. The impact of red light running camera flashes on younger and older drivers' attention and oculomotor control.

    PubMed

    Wright, Timothy J; Vitale, Thomas; Boot, Walter R; Charness, Neil

    2015-12-01

    Recent empirical evidence has suggested that the flashes associated with red light running cameras (RLRCs) distract younger drivers, pulling attention away from the roadway and delaying processing of safety-relevant events. Considering the perceptual and attentional declines that occur with age, older drivers may be especially susceptible to the distracting effects of RLRC flashes, particularly in situations in which the flash is more salient (a bright flash at night compared with the day). The current study examined how age and situational factors potentially influence attention capture by RLRC flashes using covert (cuing effects) and overt (eye movement) indices of capture. We manipulated the salience of the flash by varying its luminance and contrast with respect to the background of the driving scene (either day or night scenes). Results of 2 experiments suggest that simulated RLRC flashes capture observers' attention, but, surprisingly, no age differences in capture were observed. However, an analysis examining early and late eye movements revealed that older adults may have been strategically delaying their eye movements in order to avoid capture. Additionally, older adults took longer to disengage attention following capture, suggesting at least 1 age-related disadvantage in capture situations. Findings have theoretical implications for understanding age differences in attention capture, especially with respect to capture in real-world scenes, and inform future work that should examine how the distracting effects of RLRC flashes influence driver behavior. (c) 2015 APA, all rights reserved).

  19. The Impact of Red Light Running Camera Flashes on Younger and Older Drivers' Attention and Oculomotor Control

    PubMed Central

    Wright, Timothy J.; Vitale, Thomas; Boot, Walter R; Charness, Neil

    2015-01-01

    Recent empirical evidence suggests that the flashes associated with red light running cameras (RLRCs) distract younger drivers, pulling attention away from the roadway and delaying processing of safety-relevant events. Considering the perceptual and attentional declines that occur with age, older drivers may be especially susceptible to the distracting effects of RLRC flashes, particularly in situations in which the flash is more salient (a bright flash at night compared to the day). The current study examined how age and situational factors potentially influence attention capture by RLRC flashes using covert (cuing effects) and overt (eye movement) indices of capture. We manipulated the salience of the flash by varying its luminance and contrast with respect to the background of the driving scene (either day or night scenes). Results of two experiments suggest that simulated RLRC flashes capture observers' attention, but, surprisingly, no age differences in capture were observed. However, an analysis examining early and late eye movements revealed that older adults may have been strategically delaying their eye movements in order to avoid capture. Additionally, older adults took longer to disengage attention following capture, suggesting at least one age-related disadvantage in capture situations. Findings have theoretical implications for understanding age differences in attention capture, especially with respect to capture in real-world scenes, and inform future work that should examine how the distracting effects of RLRC flashes influence driver behavior. PMID:26479014

  20. Brain Mapping of Low and High Implusivity based P300 Signals

    NASA Astrophysics Data System (ADS)

    Turnip, Arjon; Dwi, Esti K.; Hidayat, Taufik; Hidayat, Teddy

    2018-04-01

    Impulsiveness is defined as action without good planning and with little consideration the consequences. Impulsive actions are typically poorly conceived, prematurely expressed, or inappropriate to the undesirable situation such as abuse of drugs. Instead of taking treatment for an addiction subject, it is better take prevention. In this paper, an implusivity detection based EEG-P300 potential is proposed. Twenty four subjects consist of three groups (addiction, methadone, and control) are involved in the experiment. Five different pictures (one picture related drug is used as a target) were randomly flashed to the subjects. The subject is asked to comfortly sit in a chair and to silently count the appearance number of the target. The high amplitude of the P300 component with shortest latency and dominant brain activity are indicated by high implusive group.

  1. A Plutonium Ceramic Target for MASHA

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wilk, P A; Shaughnessy, D A; Moody, K J

    2004-07-06

    We are currently developing a plutonium ceramic target for the MASHA mass separator. The MASHA separator will use a thick plutonium ceramic target capable of tolerating temperatures up to 2000 C. Promising candidates for the target include oxides and carbides, although more research into their thermodynamic properties will be required. Reaction products will diffuse out of the target into an ion source, where they will then be transported through the separator to a position-sensitive focal-plane detector array. Experiments on MASHA will allow us to make measurements that will cement our identification of element 114 and provide for future experiments wheremore » the chemical properties of the heaviest elements are studied.« less

  2. Flash LIDAR Systems for Planetary Exploration

    NASA Astrophysics Data System (ADS)

    Dissly, Richard; Weinberg, J.; Weimer, C.; Craig, R.; Earhart, P.; Miller, K.

    2009-01-01

    Ball Aerospace offers a mature, highly capable 3D flash-imaging LIDAR system for planetary exploration. Multi mission applications include orbital, standoff and surface terrain mapping, long distance and rapid close-in ranging, descent and surface navigation and rendezvous and docking. Our flash LIDAR is an optical, time-of-flight, topographic imaging system, leveraging innovations in focal plane arrays, readout integrated circuit real time processing, and compact and efficient pulsed laser sources. Due to its modular design, it can be easily tailored to satisfy a wide range of mission requirements. Flash LIDAR offers several distinct advantages over traditional scanning systems. The entire scene within the sensor's field of view is imaged with a single laser flash. This directly produces an image with each pixel already correlated in time, making the sensor resistant to the relative motion of a target subject. Additionally, images may be produced at rates much faster than are possible with a scanning system. And because the system captures a new complete image with each flash, optical glint and clutter are easily filtered and discarded. This allows for imaging under any lighting condition and makes the system virtually insensitive to stray light. Finally, because there are no moving parts, our flash LIDAR system is highly reliable and has a long life expectancy. As an industry leader in laser active sensor system development, Ball Aerospace has been working for more than four years to mature flash LIDAR systems for space applications, and is now under contract to provide the Vision Navigation System for NASA's Orion spacecraft. Our system uses heritage optics and electronics from our star tracker products, and space qualified lasers similar to those used in our CALIPSO LIDAR, which has been in continuous operation since 2006, providing more than 1.3 billion laser pulses to date.

  3. Radiation effects on active camera electronics in the target chamber at the National Ignition Facility

    NASA Astrophysics Data System (ADS)

    Dayton, M.; Datte, P.; Carpenter, A.; Eckart, M.; Manuel, A.; Khater, H.; Hargrove, D.; Bell, P.

    2017-08-01

    The National Ignition Facility's (NIF) harsh radiation environment can cause electronics to malfunction during high-yield DT shots. Until now there has been little experience fielding electronic-based cameras in the target chamber under these conditions; hence, the performance of electronic components in NIF's radiation environment was unknown. It is possible to purchase radiation tolerant devices, however, they are usually qualified for radiation environments different to NIF, such as space flight or nuclear reactors. This paper presents the results from a series of online experiments that used two different prototype camera systems built from non-radiation hardened components and one commercially available camera that permanently failed at relatively low total integrated dose. The custom design built in Livermore endured a 5 × 1015 neutron shot without upset, while the other custom design upset at 2 × 1014 neutrons. These results agreed with offline testing done with a flash x-ray source and a 14 MeV neutron source, which suggested a methodology for developing and qualifying electronic systems for NIF. Further work will likely lead to the use of embedded electronic systems in the target chamber during high-yield shots.

  4. Visual Masking During Pursuit Eye Movements

    ERIC Educational Resources Information Center

    White, Charles W.

    1976-01-01

    Visual masking occurs when one stimulus interferes with the perception of another stimulus. Investigates which matters more for visual masking--that the target and masking stimuli are flashed on the same part of the retina, or, that the target and mask appear in the same place. (Author/RK)

  5. Additions and improvements to the high energy density physics capabilities in the FLASH code

    NASA Astrophysics Data System (ADS)

    Lamb, D. Q.; Flocke, N.; Graziani, C.; Tzeferacos, P.; Weide, K.

    2016-10-01

    FLASH is an open source, finite-volume Eulerian, spatially adaptive radiation magnetohydrodynamics code that has the capabilities to treat a broad range of physical processes. FLASH performs well on a wide range of computer architectures, and has a broad user base. Extensive high energy density physics (HEDP) capabilities have been added to FLASH to make it an open toolset for the academic HEDP community. We summarize these capabilities, emphasizing recent additions and improvements. In particular, we showcase the ability of FLASH to simulate the Faraday Rotation Measure produced by the presence of magnetic fields; and proton radiography, proton self-emission, and Thomson scattering diagnostics with and without the presence of magnetic fields. We also describe several collaborations with the academic HEDP community in which FLASH simulations were used to design and interpret HEDP experiments. This work was supported in part at the University of Chicago by the DOE NNSA ASC through the Argonne Institute for Computing in Science under field work proposal 57789; and the NSF under Grant PHY-0903997.

  6. Flash photolysis of rhodopsin in the cat retina

    PubMed Central

    1981-01-01

    The bleaching of rhodopsin by short-duration flashes of a xenon discharge lamp was studied in vivo in the cat retina with the aid of a rapid, spectral-scan fundus reflectometer. Difference spectra recorded over a broad range of intensities showed that the bleaching efficacy of high-intensity flashes was less than that of longer duration, steady lights delivering the same amount of energy. Both the empirical results and those derived from a theoretical analysis of flash photolysis indicate that, under the conditions of these experiments, the upper limit of the flash bleaching of rhodopsin in cat is approximately 90%. Although the fact that a full bleach could not be attained is attributable to photoreversal, i.e., the photic regeneration of rhodopsin from its light-sensitive intermediates, the 90% limit is considerably higher than the 50% (or lower) value obtained under other experimental circumstances. Thus, it appears that the duration (approximately 1 ms) and spectral composition of the flash, coupled with the kinetic parameters of the thermal and photic reactions in the cat retina, reduce the light-induced regeneration of rhodopsin to approximately 10%. PMID:7252476

  7. Evolution of Gas Cell Targets for Magnetized Liner Inertial Fusion Experiments at the Sandia National Laboratories PECOS Test Facility

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Paguio, R. R.; Smith, G. E.; Taylor, J. L.

    Z-Beamlet (ZBL) experiments conducted at the PECOS test facility at Sandia National Laboratories (SNL) investigated the nonlinear processes in laser plasma interaction (or laserplasma instabilities LPI) that complicate the deposition of laser energy by enhanced absorption, backscatter, filamentation and beam-spray that can occur in large-scale laser-heated gas cell targets. These targets and experiments were designed to provide better insight into the physics of the laser preheat stage of the Magnetized Liner Inertial Fusion (MagLIF) scheme being tested on the SNL Z-machine. The experiments aim to understand the tradeoffs between laser spot size, laser pulse shape, laser entrance hole (LEH) windowmore » thickness, and fuel density for laser preheat. Gas cell target design evolution and fabrication adaptations to accommodate the evolving experiment and scientific requirements are also described in this paper.« less

  8. Evolution of Gas Cell Targets for Magnetized Liner Inertial Fusion Experiments at the Sandia National Laboratories PECOS Test Facility

    DOE PAGES

    Paguio, R. R.; Smith, G. E.; Taylor, J. L.; ...

    2017-12-04

    Z-Beamlet (ZBL) experiments conducted at the PECOS test facility at Sandia National Laboratories (SNL) investigated the nonlinear processes in laser plasma interaction (or laserplasma instabilities LPI) that complicate the deposition of laser energy by enhanced absorption, backscatter, filamentation and beam-spray that can occur in large-scale laser-heated gas cell targets. These targets and experiments were designed to provide better insight into the physics of the laser preheat stage of the Magnetized Liner Inertial Fusion (MagLIF) scheme being tested on the SNL Z-machine. The experiments aim to understand the tradeoffs between laser spot size, laser pulse shape, laser entrance hole (LEH) windowmore » thickness, and fuel density for laser preheat. Gas cell target design evolution and fabrication adaptations to accommodate the evolving experiment and scientific requirements are also described in this paper.« less

  9. Analog pixel array detectors.

    PubMed

    Ercan, A; Tate, M W; Gruner, S M

    2006-03-01

    X-ray pixel array detectors (PADs) are generally thought of as either digital photon counters (DPADs) or X-ray analog-integrating pixel array detectors (APADs). Experiences with APADs, which are especially well suited for X-ray imaging experiments where transient or high instantaneous flux events must be recorded, are reported. The design, characterization and experimental applications of several APAD designs developed at Cornell University are discussed. The simplest design is a ;flash' architecture, wherein successive integrated X-ray images, as short as several hundred nanoseconds in duration, are stored in the detector chips for later off-chip digitization. Radiography experiments using a prototype flash APAD are summarized. Another design has been implemented that combines flash capability with the ability to continuously stream X-ray images at slower (e.g. milliseconds) rates. Progress is described towards radiation-hardened APADs that can be tiled to cover a large area. A mixed-mode PAD, design by combining many of the attractive features of both APADs and DPADs, is also described.

  10. Investigation of multi-scale flash-weakening of rock surfaces during high speed slip

    NASA Astrophysics Data System (ADS)

    Barbery, M. R.; Saber, O.; Chester, F. M.; Chester, J. S.

    2017-12-01

    A significant reduction in the coefficient of friction of rock can occur if sliding velocity approaches seismic rates as a consequence of weakening of microscopic sliding contacts by flash heating. Using a high-acceleration and -speed biaxial apparatus equipped with a high-speed Infra-Red (IR) camera to capture thermographs of the sliding surface, we have documented the heterogeneous distribution of temperature on flash-heated decimetric surfaces characterized by linear arrays of high-temperature, mm-size spots, and streaks. Numerical models that are informed by the character of flash heated surfaces and that consider the coupling of changes in temperature and changes in the friction of contacts, supports the hypothesis that independent mechanisms of flash weakening operate at different contact scales. Here, we report on new experiments that provide additional constraints on the life-times and rest-times of populations of millimeter-scale contacts. Rock friction experiments conducted on Westerly granite samples in a double-direct shear configuration achieve velocity steps from 1 mm/s to 900 mm/s at 100g accelerations over 2 mm of displacement with normal stresses of 22-36 MPa and 30 mm of displacement during sustained high-speed sliding. Sliding surfaces are machined to roughness similar to natural fault surfaces and that allow us to control the characteristics of millimeter-scale contact populations. Thermographs of the sliding surface show temperatures up to 200 C on millimeter-scale contacts, in agreement with 1-D heat conduction model estimates of 180 C. Preliminary comparison of thermal modeling results and experiment observations demonstrate that we can distinguish the different life-times and rest-times of contacts in thermographs and the corresponding frictional weakening behaviors. Continued work on machined surfaces that lead to different contact population characteristics will be used to test the multi-scale and multi-mechanism hypothesis for flash weakening during seismic slip on rough fault surfaces.

  11. The absence of attenuating effect of red light exposure on pre-existing melanopsin-driven post-illumination pupil response.

    PubMed

    Lei, Shaobo; Goltz, Herbert C; Sklar, Jaime C; Wong, Agnes M F

    2016-07-01

    It has been proposed that after activation by blue light, activated melanopsin is converted back to its resting state by long wavelength red light exposure, a putative mechanism of melanopsin chromophore recovery in vivo. We tested this hypothesis by investigating whether red light attenuates the ongoing post-illumination pupil response (PIPR) induced by melanopsin-activating blue light. Pupillary light responses were tested using "Blue+Red" double flashes and "Blue Only" single flash stimuli in 10 visually normal subjects. For "Blue+Red" conditions, PIPR was induced with an intense blue flash, followed by experimental red light exposure of variable intensity and duration (Experiment 1) immediately or 9s after the offset of the blue flash (Experiment 2). For "Blue Only" conditions, only the PIPR-inducing blue stimuli were presented (reference condition). PIPR was defined as the mean pupil size from 10 to 30s (Experiment 1) and from 25 to 60s (Experiment 2) after the offset of blue light stimuli. The results showed that PIPR from "Blue+Red" conditions did not differ significantly from those of "Blue Only" conditions (p=0.55) in Experiment 1. The two stimulation conditions also did not differ in Experiment 2 (p=0.38). We therefore conclude that red light exposure does not alter the time course of PIPR induced by blue light. This finding does not support the hypothesis that long wavelength red light reverses activated melanopsin; rather it lends support to the hypothesis that the wavelengths of stimuli driving both the forward and backward reactions of melanopsin may be similar. Copyright © 2016. Published by Elsevier Ltd.

  12. Circulating leptin and adiponectin are associated with insulin resistance in healthy postmenopausal women with hot flashes

    PubMed Central

    Huang, Wan-Yu; Chang, Chia-Chu; Chen, Dar-Ren; Kor, Chew-Teng; Chen, Ting-Yu; Wu, Hung-Ming

    2017-01-01

    Introduction Hot flashes have been postulated to be linked to the development of metabolic disorders. This study aimed to evaluate the relationship between hot flashes, adipocyte-derived hormones, and insulin resistance in healthy, non-obese postmenopausal women. Participants and design In this cross-sectional study, a total of 151 women aged 45–60 years were stratified into one of three groups according to hot-flash status over the past three months: never experienced hot flashes (Group N), mild-to-moderate hot flashes (Group M), and severe hot flashes (Group S). Variables measured in this study included clinical parameters, hot flash experience, fasting levels of circulating glucose, lipid profiles, plasma insulin, and adipocyte-derived hormones. Multiple linear regression analysis was used to evaluate the associations of hot flashes with adipocyte-derived hormones, and with insulin resistance. Settings The study was performed in a hospital medical center. Results The mean (standard deviation) of body-mass index was 22.8(2.7) for Group N, 22.6(2.6) for Group M, and 23.5(2.4) for Group S, respectively. Women in Group S displayed statistically significantly higher levels of leptin, fasting glucose, and insulin, and lower levels of adiponectin than those in Groups M and N. Multivariate linear regression analysis revealed that hot-flash severity was significantly associated with higher leptin levels, lower adiponectin levels, and higher leptin-to-adiponectin ratio. Univariate linear regression analysis revealed that hot-flash severity was strongly associated with a higher HOMA-IR index (% difference, 58.03%; 95% confidence interval, 31.00–90.64; p < 0.001). The association between hot flashes and HOMA-IR index was attenuated after adjusting for leptin or adiponectin and was no longer significant after simultaneously adjusting for leptin and adiponectin. Conclusion The present study provides evidence that hot flashes are associated with insulin resistance in postmenopausal women. It further suggests that hot flash association with insulin resistance is dependent on the combination of leptin and adiponectin variables. PMID:28448547

  13. Flash Kα radiography of laser-driven solid sphere compression for fast ignition

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sawada, H.; Lee, S.; Shiroto, T.

    2016-06-20

    Time-resolved compression of a laser-driven solid deuterated plastic sphere with a cone was measured with flash Kα x-ray radiography. A spherically converging shockwave launched by nanosecond GEKKO XII beams was used for compression while a flash of 4.51 keV Ti Kα x-ray backlighter was produced by a high-intensity, picosecond laser LFEX (Laser for Fast ignition EXperiment) near peak compression for radiography. Areal densities of the compressed core were inferred from two-dimensional backlit x-ray images recorded with a narrow-band spherical crystal imager. The maximum areal density in the experiment was estimated to be 87 ± 26 mg/cm 2. Lastly, the temporalmore » evolution of the experimental and simulated areal densities with a 2-D radiation-hydrodynamics code is in good agreement.« less

  14. Flash Kα radiography of laser-driven solid sphere compression for fast ignition

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sawada, H.; Lee, S.; Nagatomo, H.

    2016-06-20

    Time-resolved compression of a laser-driven solid deuterated plastic sphere with a cone was measured with flash Kα x-ray radiography. A spherically converging shockwave launched by nanosecond GEKKO XII beams was used for compression while a flash of 4.51 keV Ti Kα x-ray backlighter was produced by a high-intensity, picosecond laser LFEX (Laser for Fast ignition EXperiment) near peak compression for radiography. Areal densities of the compressed core were inferred from two-dimensional backlit x-ray images recorded with a narrow-band spherical crystal imager. The maximum areal density in the experiment was estimated to be 87 ± 26 mg/cm{sup 2}. The temporal evolution of the experimental andmore » simulated areal densities with a 2-D radiation-hydrodynamics code is in good agreement.« less

  15. The Thermal Diffusivity Measurement of the Two-layer Ceramics Using the Laser Flash Methodn

    NASA Astrophysics Data System (ADS)

    Akoshima, Megumi; Ogwa, Mitsue; Baba, Tetsuya; Mizuno, Mineo

    Ceramics-based thermal barrier coatings are used as heat and wear shields of gas turbines. There are strong needs to evaluate thermophysical properties of coating, such as thermal conductivity, thermal diffusivity and heat capacity of them. Since the coatings are attached on substrates, it is no easy to measure these properties separately. The laser flash method is one of the most popular thermal diffusivity measurement methods above room temperature for solid materials. The surface of the plate shape specimen is heated by the pulsed laser-beam, then the time variation of the temperature of the rear surface is observed by the infrared radiometer. The laser flash method is non-contact and short time measurement. In general, the thermal diffusivity of solids that are dense, homogeneous and stable, are measured by this method. It is easy to measure thermal diffusivity of a specimen which shows heat diffusion time about 1 ms to 1 s consistent with the specimen thickness of about 1 mm to 5 mm. On the other hand, this method can be applied to measure the specific heat capacity of the solids. And it is also used to estimate the thermal diffusivity of an unknown layer in the layered materials. In order to evaluate the thermal diffusivity of the coating attached on substrate, we have developed a measurement procedure using the laser flash method. The multi-layer model based on the response function method was applied to calculate the thermal diffusivity of the coating attached on substrate from the temperature history curve observed for the two-layer sample. We have verified applicability of the laser flash measurement with the multi-layer model using the measured results and the simulation. It was found that the laser flash measurement for the layered sample using the multi-layer model was effective to estimate the thermal diffusivity of an unknown layer in the sample. We have also developed the two-layer ceramics samples as the reference materials for this procedure.

  16. SMIS PBX-9502 Test Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Marr-Lyon, Mark; Sandoval, Thomas D.; Herrera, Dennis H.

    2014-04-11

    Two impact experiments in the Specific Munitions Impact Scenario (SMIS) configuration [1{3] were performed on September 3 and 4, 2013 at Lower Slobbovia ring site. Targets of the high explosive PBX-9502 were impacted with 1/2-inch diameter low-carbon steel spheres red from a 30-mm powder gun at velocities of approximately 2.5 km/s. In one experiment the target was cased in a steel cylinder with steel end plates, and in the second the target was cased in a plastic cylinder with a thin steel front cover plate and a thick steel rear plate. In neither experiment did the PBX-9502 detonate, though somemore » material reacted in the impact« less

  17. Lα and Mαβ X-ray production cross-sections of Bi by 6-30 keV electron impact

    NASA Astrophysics Data System (ADS)

    Liang, Y.; Xu, M. X.; Yuan, Y.; Wu, Y.; Qian, Z. C.; Chang, C. H.; Mei, C. S.; Zhu, J. J.; Moharram, K.

    2017-12-01

    In this paper, the Lα and Mαβ X-ray production cross-sections for Bi impacted by 6-30 keV electron have been measured. The experiments were performed at a Scanning Electron Microscope equipped with a silicon drift detector. The thin film with thick C substrate and the thin film deposited on self-supporting thin C film were both used as the targets to make a comparison. For the thick carbon substrate target, the Monte Carlo method has been used to eliminate the contribution of backscattering particles. The measured data are compared with the DWBA theoretical model and the experimental results in the literature. The experimental data for the thin film with thick C substrate target and the thin film deposited on self-supporting thin C film target are within reasonable gaps. The DWBA theoretical model gives good fit to the experimental data both for L- and M- shells. Besides, we also analyze the reasons why the discrepancies exist between our measurements and the experimental results in the literature.

  18. A comparative study on the effect of "black cohosh" and "evening primrose oil" on menopausal hot flashes.

    PubMed

    Mehrpooya, Maryam; Rabiee, Soghra; Larki-Harchegani, Amir; Fallahian, Amir-Mohammad; Moradi, Abbas; Ataei, Sara; Javad, Masoumeh Taravati

    2018-01-01

    Hot flashes are considered to be a common experience for menopausal women and they can compromise the quality of life. The objective of this study is to assess the efficacy of Cimicifuga racemosa in comparison with evening primrose oil (EPO) in postmenopausal women with menopause-related symptoms. This study was performed on 80 postmenopausal women with hot flashes. The participants were randomly divided into two groups by blocked randomization. The participants of one group received black cohosh and the other group received EPO for 8 weeks. The severity and number of hot flashes and quality of life were measured by four-point scale, and the Menopause-Specific Quality of Life (MENQOL) questionnaire at pre-intervention, 1 st , 4 th , and 8 th weeks after treatment. Data were analyzed in SPSS Version 16 using independent t -test, Chi-square, and Fisher's exact test. Average severity of hot flashes in both groups and number of hot flashes in black cohosh group in 8 th week were significantly lower than 1 st week ( P < 0.001), but number of hot flashes in primrose oil group in 8 th week showed no significant differences ( P = 0.32). The number of hot flashes and quality of life score in black cohosh arm compared to EPO showed a significant decrease in the 8 th week ( P < 0.05). All MENQOL scores were significantly improved in two groups ( P < 0.05), but the percentage of improvement in black cohosh arm was significantly superior to EPO group. Both herbs were effective in reduction of severity of hot flashes and improvement of the quality of life, but it seems that black cohosh is more effective than primrose oil because it was able to reduce the number of hot flashes too.

  19. A comparison of colour, shape, and flash induced illusory line motion.

    PubMed

    Hamm, Jeff P

    2017-04-01

    When a bar suddenly appears between two boxes, the bar will appear to shoot away from the box that matches it in colour or in shape-a phenomenon referred to as attribute priming of illusory line motion (ILM; colour ILM and shape ILM, respectively). If the two boxes are identical, ILM will still occur away from a box if it changes luminance shortly before the presentation of the bar ( flash ILM). This flash condition has been suggested to produce the illusory motion due to the formation of an attentional gradient surrounding the flashed location. However, colour ILM and shape ILM cannot be explained by an attentional gradient as there is no way for attention to select the matching box prior to the presentation of the bar. These findings challenge the attentional gradient explanation for ILM, but only if it is assumed that ILM arises for the same underlying reason. Two experiments are presented that address the question of whether or not flash ILM is the same as colour ILM or shape ILM. The results suggest that while colour ILM and shape ILM reflect a common illusion, flash ILM arises for a different reason. Therefore, the attentional gradient explanation for flash ILM is not refuted by the occurrence of colour ILM or shape ILM, which may reflect transformational apparent motion (TAM).

  20. Spectral measurements of muzzle flash with multispectral and hyperspectral sensor

    NASA Astrophysics Data System (ADS)

    Kastek, M.; Dulski, R.; Trzaskawka, P.; Piątkowski, T.; Polakowski, H.

    2011-08-01

    The paper presents some practical aspects of the measurements of muzzle flash signatures. Selected signatures of sniper shot in typical scenarios has been presented. Signatures registered during all phases of muzzle flash were analyzed. High precision laboratory measurements were made in a special ballistic laboratory and as a result several flash patterns were registered. The field measurements of a muzzle flash were also performed. During the tests several infrared cameras were used, including the measurement class devices with high accuracy and frame rates. The registrations were made in NWIR, SWIR and LWIR spectral bands simultaneously. An ultra fast visual camera was also used for visible spectra registration. Some typical infrared shot signatures were presented. Beside the cameras, the LWIR imaging spectroradiometer HyperCam was also used during the laboratory experiments and the field tests. The signatures collected by the HyperCam device were useful for the determination of spectral characteristics of the muzzle flash, whereas the analysis of thermal images registered during the tests provided the data on temperature distribution in the flash area. As a result of the measurement session the signatures of several types handguns, machine guns and sniper rifles were obtained which will be used in the development of passive infrared systems for sniper detection.

  1. Undergraduate Separations Utilizing Flash Chromatography

    NASA Astrophysics Data System (ADS)

    Horowitz, G.

    2000-02-01

    This article describes the procedures used to carry out four flash chromatography experiments: the isolation of the carotenes, chlorophylls and xanthophylls from a spinach extract; the separation of ß-carotene from tetraphenyl cyclopentadienone; the isolation of (+) and (-) carvone from caraway and spearmint oil; and the purification of benzil from benzoin. Apparatus used is nonbreakable, easy to use, and inexpensive.

  2. A low power flash-FPGA based brain implant micro-system of PID control.

    PubMed

    Lijuan Xia; Fattah, Nabeel; Soltan, Ahmed; Jackson, Andrew; Chester, Graeme; Degenaar, Patrick

    2017-07-01

    In this paper, we demonstrate that a low power flash FPGA based micro-system can provide a low power programmable interface for closed-loop brain implant inter- faces. The proposed micro-system receives recording local field potential (LFP) signals from an implanted probe, performs closed-loop control using a first order control system, then converts the signal into an optogenetic control stimulus pattern. Stimulus can be implemented through optoelectronic probes. The long term target is for both fundamental neuroscience applications and for clinical use in treating epilepsy. Utilizing our device, closed-loop processing consumes only 14nJ of power per PID cycle compared to 1.52μJ per cycle for a micro-controller implementation. Compared to an application specific digital integrated circuit, flash FPGA's are inherently programmable.

  3. Selective attention and subjective confidence calibration.

    PubMed

    Schoenherr, Jordan R; Leth-Steensen, Craig; Petrusic, William M

    2010-02-01

    In the present experiments, failures of selective visual attention were invoked using the B. A. Eriksen and C. W. Eriksen (1974) flanker task. On each trial, a three-letter stimulus array was flashed briefly, followed by a mask. The identity of the two flanking letters was response congruent, neutral, or incongruent with the identity of the middle target letter. On half of the trials, confidence ratings were obtained after each response. In the first three experiments, participants were highly overconfident in the accuracy of their responding to incongruent flanker stimulus arrays. In a final experiment, presenting a prestimulus target location cue greatly reduced both selective attention failure and overconfidence. The findings demonstrate that participants are often unaware of such selective attention failures and provide support for the notion that, in these cases, decisional processing is driven largely by the identities of the incongruent flankers. In addition, responding was invariably slower and sometimes more accurate when confidence was required than when it was not required, demonstrating that the need to provide posttrial confidence reports can affect decisional processing. Moreover, there was some evidence that the presence of neutral contextual flanking information can slow responding, suggesting that such nondiagnostic information can, indeed, contribute to decisional processing.

  4. Non-contact online thickness measurement system for metal films based on eddy current sensing with distance tracking technique.

    PubMed

    Li, Wei; Wang, Hongbo; Feng, Zhihua

    2016-04-01

    This paper proposes an online, non-contact metal film thickness measurement system based on eddy current sensing. The slope of the lift-off curve (LOC) is used for characterizing target thickness. Theoretical derivation was conducted to prove that the slope is independent of the lift-off variation. In practice, the measurement has some immunity to the lift-off, but not perfect. The slope of LOC is still affected at some extent by the lift-off. Hence, a height tracking system was also proposed, which could stabilize the distance between the sensor and the target and significantly reduce the lift-off effect. The height tracking system contains a specially designed probe, which could vibrate rapidly to obtain a fast measurement speed, and its height can be adjusted up and down continuously to stabilize the lift-off. The sensor coil in the thickness measurement system was also used as the height sensor in the height tracking system. Several experiments were conducted to test the system performances under static and dynamic conditions. This measurement system demonstrated significant advantages, such as simple and clear conversion between the slope of LOC and target thickness, high resolution and stability, and minimized effect of lift-off variation.

  5. Optical countermeasures against CLOS weapon systems

    NASA Astrophysics Data System (ADS)

    Toet, Alexander; Benoist, Koen W.; van Lingen, Joost N. J.; Schleijpen, H. Ric M. A.

    2013-10-01

    There are many weapon systems in which a human operator acquires a target, tracks it and designates it. Optical countermeasures against this type of systems deny the operator the possibility to fulfill this visual task. We describe the different effects that result from stimulation of the human visual system with high intensity (visible) light, and the associated potential operational impact. Of practical use are flash blindness, where an intense flash of light produces a temporary "blind-spot" in (part of) the visual field, flicker distraction, where strong intensity and/or color changes at a discomfortable frequency are produced, and disability glare where a source of light leads to contrast reduction. Hence there are three possibilities to disrupt the visual task of an operator with optical countermeasures such as flares or lasers or a combination of these; namely, by an intense flash of light, by an annoying light flicker or by a glare source. A variety of flares for this purpose is now available or under development: high intensity flash flares, continuous burning flares or strobe flares which have an oscillating intensity. The use of flare arrays seems particularly promising as an optical countermeasure. Lasers are particularly suited to interfere with human vision, because they can easily be varied in intensity, color and size, but they have to be directed at the (human) target, and issues like pointing and eye-safety have to be taken into account. Here we discuss the design issues and the operational impact of optical countermeasures against human operators.

  6. THz pulses from 4th generation X-ray light sources: Perspectives for fully synchronized THz pump X-ray probe experiments

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gensch, M.

    2010-02-03

    In this paper the prospects of terahertz (THz) pulses generated at 4th generation X-ray light sources are presented on the example of recent results from a prototype set-up at the soft X-ray FEL FLASH. It is shown, that the THz pulses from the relativistic ultra short electron bunches have unique properties, that at FLASH are utilized for novel THz pump X-ray probe experiments with a robust few fs resolution. Based on these experiences it is discussed, how future facilities can benefit from implementation of similar or further improved instrumentation.

  7. The Effect of Arrow Mass and Shape on Penetration into a Target

    NASA Astrophysics Data System (ADS)

    Shyam, S.; Gurram, A.; Madireddy, S.

    2016-12-01

    We conducted an archery experiment in order to quantify how aerodynamic design impacted the depth of arrow impact. Research shows that the smaller the surface area of an object, the more easily it travels through the air and the deeper it penetrates a target (Benson 2014). Momentum also affects how far and fast the arrow will go and therefore, how deep it will penetrate into the target. Therefore, a combination of an arrow with greater momentum and better aerodynamics will help the arrow fly faster and penetrate the target deeper. Mass, velocity, momentum, acceleration, force, and drag are the factors that acted on our experiment and produced its results. We hypothesized that the arrow with a thin shaft and pointed arrowhead would penetrate deepest, as opposed to both arrows with no arrowheads or arrows with thick shafts and blunt arrowheads. We tested our hypothesis by having a well-trained archer shoot different types of arrows into a target. We used arrows with shaft lengths of 7 cm and 5.3 cm, coupled with either pointed, blunt, or no arrowhead. We measured the time to target and arrow penetration (in cm) to see which style reached the target the fastest and penetrated the deepest. The results demonstrated that arrows with thin shafts and pointed arrowheads penetrated our target the deepest, followed by arrows with thick shafts and blunt arrowheads. Arrows with thin shafts and blunt arrowheads came after, and arrows with thick shafts and pointed arrowheads came last in depth of penetration. The arrows with no arrowheads either barely penetrated the target, or bounced back. We were able to conclude that the thinner the shaft and the more pointed the arrowhead, the better the arrow cuts the air. This is because, according to the principles of aerodynamics, it creates less drag since the surface area is smaller. However, mass also plays an important role in force through momentum, which also significantly affected our results.

  8. Lightning-Generated NO(x) Seen By OMI during NASA's TC-4 Experiment: First Results

    NASA Technical Reports Server (NTRS)

    Bucsela, Eric; Pickering, Kenneth E.; Huntemann, Tabitha; Cohen, Ronald; Perring, Anne; Gleason, James; Blakeslee, Richard; Navarro, Dylana Vargas; Segura, Ileana Mora; Hernandez, Alexia Pacheco; hide

    2009-01-01

    We present here case studies identifying upper-tropospheric NO2 produced in convective storms during NASA's Tropical Composition, Cloud and Climate Coupling Experiment (TCi)n July and August 2007. DC8 aircraft missions, flown from the mission base in Costa Rica, recorded in situ NO2 profiles near active storms and in relatively quiet areas. We combine these data with measurements from the Ozone Monitoring Instrument (OMI) on the Aura satellite to estimate the amount of NO2 produced by lightning (LN02) above background levels in the regions influenced by storms. In our analysis, improved off-line processing techniques are employed to minimize known artifacts in the OM1 data. Information on lightning flashes (primarily CG) observed by the surface network operated by the Instituto Costarricense de Electricidad are examined upwind of regions where OM1 indicates enhanced LNO2. Comparisons of the observed flash data with measurements by the TRMM/LIS satellite instrument are used to obtain the lightning detection efficiency for total flashes. Finally, using the NO/NO2 ratio estimated from DC-8 observations, we estimate the average NO(x) production per lightning flash for each case in this study. The magnitudes of the measured NO(x) enhancements are compared with those observed by the DC-8 and with similar OM1 measurements analyzed in mid-latitude experiments.

  9. Final report SI 08-SI-004: Fusion application targets

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Biener, J; Kucheyev, S O; Wang, M Y

    2010-12-03

    Complex target structures are necessary to take full advantage of the unique laboratory environment created by inertial confinement fusion experiments. For example, uses-of-ignition targets that contain a thin layer of a low density nanoporous material inside a spherical ablator shell allow placing dopants in direct contact with the DT fuel. The ideal foam for this application is a low-density hydrocarbon foam that is strong enough to survive wetting with cryogenic hydrogen, and low enough in density (density less than {approx}30 mg/cc) to not reduce the yield of the target. Here, we discuss the fabrication foam-lined uses-of-ignition targets, and the developmentmore » of low-density foams that can be used for this application. Much effort has been directed over the last 20 years toward the development of spherical foam targets for direct-drive and fast-ignition experiments. In these targets, the spherical foam shell is used to define the shape of the cryogenic DT fuel layer, or acts as a surrogate to simulate the cryogenic fuel layer. These targets are fabricated from relatively high-density aerogels (>100 mg/cc) and coated with a few micron thick permeation barrier. With exception of the above mentioned fast ignition targets, the wall of these targets is typically larger than 100 microns. In contrast, the fusion application targets for indirect-drive experiments on NIF will require a much thinner foam shell surrounded by a much thicker ablator shell. The design requirements for both types of targets are compared in Table 1. The foam shell targets for direct-drive experiments can be made in large quantities and with reasonably high yields using an encapsulation technique pioneered by Takagi et al. in the early 90's. In this approach, targets are made by first generating unsupported foam shells using a triple-orifice droplet generator, followed by coating the dried foam shells with a thin permeation barrier. However, this approach is difficult, if not impossible, to transfer to the lower density and thinner wall foam shells required for indirect-drive uses-of-ignition targets for NIF that then would have to be coated with an at least hundred-micron-thick ablator film. So far, the thinnest shells that have been fabricated using the triple-orifice-droplet generator technique had a wall thickness of {approx}20 microns, but despite of being made from a higher-density foam formulation, the shells were mechanically very sensitive, difficult to dry, and showed large deviations from roundness. We thus decided to explore a different approach based on using prefabricated thick-walled spherical ablator shells as templates for the thin-walled foam shell. As in the case of the above mentioned encapsulation technique, the foam is made by sol-gel chemistry. However, our approach removes much the requirements on the mechanical stability of the foam shell as the foam shell is never handled in its free-standing form, and promises superior ablator uniformity and surface roughness. As discussed below, the success of this approach depends strongly on the availability of suitable aerogel chemistries (ideally pure hydrocarbon (CH)-based systems) with suitable rheological properties (high viscosity and high modulus near the gel point) that produce low-density and mechanically strong foams.« less

  10. Micrometer-thickness liquid sheet jets flowing in vacuum

    NASA Astrophysics Data System (ADS)

    Galinis, Gediminas; Strucka, Jergus; Barnard, Jonathan C. T.; Braun, Avi; Smith, Roland A.; Marangos, Jon P.

    2017-08-01

    Thin liquid sheet jet flows in vacuum provide a new platform for performing experiments in the liquid phase, for example X-ray spectroscopy. Micrometer thickness, high stability, and optical flatness are the key characteristics required for successful exploitation of these targets. A novel strategy for generating sheet jets in vacuum is presented in this article. Precision nozzles were designed and fabricated using high resolution (0.2 μm) 2-photon 3D printing and generated 1.49 ± 0.04 μm thickness, stable, and <λ /20-flat jets in isopropanol under normal atmosphere and under vacuum at 5 × 10-1 mbar. The thin sheet technology also holds great promise for advancing the fields of high harmonic generation in liquids, laser acceleration of ions as well as other fields requiring precision and high repetition rate targets.

  11. Investigations in x-radiation stimulation

    NASA Astrophysics Data System (ADS)

    Gupta, K. D.

    1982-03-01

    The objective is to invent a crystal x-ray laser. Investigations in the Radiation Research Lab. at Texas Tech University have established in a very straightforward way the line narrowing associated with a threshold pumping and a nonlinear rise in intensity. Recent work on x-ray Borrmann channeling via monocrystals has demonstrated the existence of a monochromatic x-ray beam without any vertical divergence. This would allow the transport of x-ray energy in space for thousands of miles without any loss of power. Preliminary experiments with a monocrystal excited by pulsed x-rays at Air Force Weapons Laboratory, KAFB, Albuquerque, seem to indicate a gain in intensity of the nondivergent hot spot with a concomitant fading of the regular Laue pattern. Current investigations in this line indicates that with proper doping of the monocrystal the nondivergent beam could be increased in intensity using a flash x-ray tube to pump the doped monocrystal. A concial target double beam flash x-ray line source instrument has been constructed to obtain a beam of nondivergent, stimulated, coherent, and monochromatic x-rays from doped monocrystals. A generation of stimulated x-rays using bunched electrons from pulsed high power klystron striking a monocrystal has been conceived.

  12. Laser flash-photolysis and gas discharge in N2O-containing mixture: kinetic mechanism

    NASA Astrophysics Data System (ADS)

    Kosarev, Ilya; Popov, Nikolay; Starikovskaia, Svetlana; Starikovskiy, Andrey; mipt Team

    2011-10-01

    The paper is devoted to further experimental and theoretical analysis of ignition by ArF laser flash-photolysis and nanosecond discharge in N2O-containing mixture has been done. Additional experiments have been made to assure that laser emission is distributed uniformly throughout the cross-section. The series of experiments was proposed and carried out to check validity of O(1D) determination in experiments on plasma assisted ignition initiated by flash-photolysis. In these experiments, ozone density in the given mixture (mixture composition and kinetics has been preliminary analyzed) was measured using UV light absorption in Hartley band. Good coincidence between experimental data and results of calculations have been obtained Temporal behavior of energy input, electric field and electric current has been measured and analyzed. These data are considered as initial conditions for numerical modeling of the discharge in O2:N2O:H2:Ar = 0.3:1:3:5 mixture. Ion-molecular reactions and reactions of active species production in Ar:H2:O2:N2O mixture were analyzed. The set of reactions to describe chemical transformation in the system due to the discharge action has been selected.

  13. Monte Carlo Radiative Transfer Modeling of Lightning Observed in Galileo Images of Jupiter

    NASA Technical Reports Server (NTRS)

    Dyudine, U. A.; Ingersoll, Andrew P.

    2002-01-01

    We study lightning on Jupiter and the clouds illuminated by the lightning using images taken by the Galileo orbiter. The Galileo images have a resolution of 25 km/pixel and axe able to resolve the shape of the single lightning spots in the images, which have full widths at half the maximum intensity in the range of 90-160 km. We compare the measured lightning flash images with simulated images produced by our ED Monte Carlo light-scattering model. The model calculates Monte Carlo scattering of photons in a ED opacity distribution. During each scattering event, light is partially absorbed. The new direction of the photon after scattering is chosen according to a Henyey-Greenstein phase function. An image from each direction is produced by accumulating photons emerging from the cloud in a small range (bins) of emission angles. Lightning bolts are modeled either as points or vertical lines. Our results suggest that some of the observed scattering patterns axe produced in a 3-D cloud rather than in a plane-parallel cloud layer. Lightning is estimated to occur at least as deep as the bottom of the expected water cloud. For the six cases studied, we find that the clouds above the lightning are optically thick (tau > 5). Jovian flashes are more regular and circular than the largest terrestrial flashes observed from space. On Jupiter there is nothing equivalent to the 30-40-km horizontal flashes which axe seen on Earth.

  14. Imaging Flash Lidar for Safe Landing on Solar System Bodies and Spacecraft Rendezvous and Docking

    NASA Technical Reports Server (NTRS)

    Amzajerdian, Farzin; Roback, Vincent E.; Bulyshev, Alexander E.; Brewster, Paul F.; Carrion, William A; Pierrottet, Diego F.; Hines, Glenn D.; Petway, Larry B.; Barnes, Bruce W.; Noe, Anna M.

    2015-01-01

    NASA has been pursuing flash lidar technology for autonomous, safe landing on solar system bodies and for automated rendezvous and docking. During the final stages of the landing from about 1 kilometer to 500 meters above the ground, the flash lidar can generate 3-Dimensional images of the terrain to identify hazardous features such as craters, rocks, and steep slopes. The onboard flight computer can then use the 3-D map of terrain to guide the vehicle to a safe location. As an automated rendezvous and docking sensor, the flash lidar can provide relative range, velocity, and bearing from an approaching spacecraft to another spacecraft or a space station. NASA Langley Research Center has developed and demonstrated a flash lidar sensor system capable of generating 16,000 pixels range images with 7 centimeters precision, at 20 Hertz frame rate, from a maximum slant range of 1800 m from the target area. This paper describes the lidar instrument and presents the results of recent flight tests onboard a rocket-propelled free-flyer vehicle (Morpheus) built by NASA Johnson Space Center. The flights were conducted at a simulated lunar terrain site, consisting of realistic hazard features and designated landing areas, built at NASA Kennedy Space Center specifically for this demonstration test. This paper also provides an overview of the plan for continued advancement of the flash lidar technology aimed at enhancing its performance to meet both landing and automated rendezvous and docking applications.

  15. Effect of Target Thickness on Cratering and Penetration of Projectiles Impacting at Velocities to 13,000 Feet Per Second

    NASA Technical Reports Server (NTRS)

    Kinard, William H.; Lambert, C. H., Jr.; Schryer, David R.; Casey, Francis W., Jr.

    1958-01-01

    In order to determine the effects of target thickness on the penetration and cratering of a target resulting from impacts by high-velocity projectiles, a series of experimental tests have been run. The projectile-target material combinations investigated were aluminum projectiles impacting aluminum targets and steel projectiles impacting aluminum and copper targets. The velocity spectrum ranged from 4,000 ft/sec to 13,000 ft/sec. It has been found that the penetration is a function of target thickness provided that the penetration is greater than 20 percent of the target thickness. Targets of a thickness such that the penetration amounts to less than 20 percent of the thickness may be regarded as quasi-infinite. An empirical formula has been established relating the penetration to the target thickness and to the penetration of a projectile of the same mass, configuration, and velocity into a quasi- infinite target. In particular, it has been found that a projectile can completely penetrate a target whose thickness is approximately one and one-half times as great as the penetration of a similar projectile into a quasi-infinite target. The diameter of a crater has also been found to be a function of the target thickness provided that the target thickness is not greater than the projectile length in the case of cylindrical projectiles and not greater than two to three times the projectile diameter in the case of spherical projectiles.

  16. The magnetically driven plasma jet produces a pressure of 33 GPa on PTS

    NASA Astrophysics Data System (ADS)

    Xu, Qiang; Dan, Jiakun; Wang, Guilin; Guo, Shuai; Zhang, Siqun; Cai, Hongchun; Ren, Xiao; Wang, Kunlun; Zhou, Shaotong; Zhang, Zhaohui; Huang, Xianbin

    2017-01-01

    We report on experiments in which a magnetically driven plasma jet was used to hit a 500 μm thick planar aluminum target. The plasma jet was produced by using a 50 μm thick aluminum radial foil, which was subjected to 4 MA, 90 ns rising time current on the primary test stand pulsed power facility. The subsequent magnetic bubbles propagate with radial velocity reaching 200 km/s and an axial velocity of 230 km/s. After the plasma knocks onto the target, a shock forms in the target. When the shock gets to the backside of the target, we measure the velocity of the moving surface using dual laser heterodyne velocimetry. By using the Hugoniot relations, we know that the plasma jet produced a pressure of 33 GPa. According to the measured pressure and the velocity of the plasma jet, the density of the jet can be also roughly estimated.

  17. Diurnal rhythm and concordance between objective and subjective hot flashes: the Hilo Women's Health Study.

    PubMed

    Sievert, Lynnette L; Reza, Angela; Mills, Phoebe; Morrison, Lynn; Rahberg, Nichole; Goodloe, Amber; Sutherland, Michael; Brown, Daniel E

    2010-01-01

    The aims of this study were to test for a diurnal pattern in hot flashes in a multiethnic population living in a hot, humid environment and to examine the rates of concordance between objective and subjective measures of hot flashes using ambulatory and laboratory measures. Study participants aged 45 to 55 years were recruited from the general population of Hilo, HI. Women wore a Biolog hot flash monitor (UFI, Morro Bay, CA), kept a diary for 24 hours, and also participated in 3-hour laboratory measures (n = 199). Diurnal patterns were assessed using polynomial regression. For each woman, objectively recorded hot flashes that matched subjective experience were treated as true-positive readings. Subjective hot flashes were considered the standard for computing false-positive and false-negative readings. True-positive, false-positive, and false-negative readings were compared across ethnic groups by chi analyses. Frequencies of sternal, nuchal, and subjective hot flashes peaked at 1500 +/- 1 hours with no difference by ethnicity. Laboratory results supported the pattern seen in ambulatory monitoring. Sternal and nuchal monitoring showed the same frequency of true-positive measures, but nonsternal electrodes picked up more false-positive readings. Laboratory monitoring showed very low frequencies of false negatives. There were no ethnic differences in the frequency of true-positive or false-positive measures. Women of European descent were more likely to report hot flashes that were not objectively demonstrated (false-negative measures). The diurnal pattern and peak in hot flash occurrence in the hot humid environment of Hilo were similar to results from more temperate environments. Lack of variation in sternal versus nonsternal measures and in true-positive measures across ethnicities suggests no appreciable effect of population variation in sweating patterns.

  18. Diurnal rhythm and concordance between objective and subjective hot flashes: The Hilo Women’s Health Study

    PubMed Central

    Sievert, Lynnette L.; Reza, Angela; Mills, Phoebe; Morrison, Lynn; Rahberg, Nichole; Goodloe, Amber; Sutherland, Michael; Brown, Daniel E.

    2010-01-01

    Objective To test for a diurnal pattern in hot flashes in a multi-ethnic population living in a hot, humid environment. To examine rates of concordance between objective and subjective measures of hot flashes using ambulatory and laboratory measures. Methods Study participants aged 45–55 were recruited from the general population of Hilo, Hawaii. Women wore a Biolog hot flash monitor, kept a diary for 24-hours, and also participated in 3-hour laboratory measures (n=199). Diurnal patterns were assessed using polynomial regression. For each woman, objectively recorded hot flashes that matched subjective experience were treated as true positive readings. Subjective hot flashes were considered the standard for computing false positive and false negative readings. True positive, false positive, and false negative readings were compared across ethnic groups by chi-square analyses. Results Frequencies of sternal, nuchal and subjective hot flashes peaked at 15:00 ± 1 hour with no difference by ethnicity. Laboratory results supported the pattern seen in ambulatory monitoring. Sternal and nuchal monitoring showed the same frequency of true positive measures, but non-sternal electrodes picked up more false positive readings. Laboratory monitoring showed very low frequencies of false negatives. There were no ethnic differences in the frequency of true positive or false positive measures. Women of European descent were more likely to report hot flashes that were not objectively demonstrated (false negative measures). Conclusions The diurnal pattern and peak in hot flash occurrence in the hot humid environment of Hilo was similar to results from more temperate environments. Lack of variation in sternal vs. non-sternal measures, and in true positive measures across ethnicities suggests no appreciable effect of population variation in sweating patterns. PMID:20220538

  19. Light flash phenomena induced by HzE particles

    NASA Technical Reports Server (NTRS)

    Mcnulty, P. J.; Pease, V. P.

    1980-01-01

    Astronauts and Apollo and Skylab missions have reported observing a variety of visual phenomena when their eyes are closed and adapted to darkness. These phenomena have been collectively labelled as light flashes. Visual phenomena which are similar in appearance to those observed in space have been demonstrated at the number of accelerator facilities by expressing the eyes of human subjects to beams of various types of radiation. In some laboratory experiments Cerenkov radiation was found to be the basis for the flashes observed while in other experiments Cerenkov radiation could apparently be ruled out. Experiments that differentiate between Cerenkov radiation and other possible mechanisms for inducing visual phenomena was then compared. The phenomena obtained in the presence and absence of Cerenkov radiation were designed and conducted. A new mechanism proposed to explain the visual phenomena observed by Skylab astronauts as they passed through the South Atlantic Anomaly, namely nuclear interactions in and near the sensitive layer of the retina, is covered. Also some studies to search for similar transient effects of space radiation on sensors and microcomputer memories are described.

  20. Shielded Heavy-Ion Environment Linear Detector (SHIELD): an experiment for the Radiation and Technology Demonstration (RTD) Mission.

    PubMed

    Shavers, M R; Cucinotta, F A; Miller, J; Zeitlin, C; Heilbronn, L; Wilson, J W; Singleterry, R C

    2001-01-01

    Radiological assessment of the many cosmic ion species of widely distributed energies requires the use of theoretical transport models to accurately describe diverse physical processes related to nuclear reactions in spacecraft structures, planetary atmospheres and surfaces, and tissues. Heavy-ion transport models that were designed to characterize shielded radiation fields have been validated through comparison with data from thick-target irradiation experiments at particle accelerators. With the RTD Mission comes a unique opportunity to validate existing radiation transport models and guide the development of tools for shield design. For the first time, transport properties will be measured in free-space to characterize the shielding effectiveness of materials that are likely to be aboard interplanetary space missions. Target materials composed of aluminum, advanced composite spacecraft structure and other shielding materials, helium (a propellant) and tissue equivalent matrices will be evaluated. Large solid state detectors will provide kinetic energy and charge identification for incident heavy-ions and for secondary ions created in the target material. Transport calculations using the HZETRN model suggest that 8 g cm -2 thick targets would be adequate to evaluate the shielding effectiveness during solar minimum activity conditions for a period of 30 days or more.

  1. An Evaluation of Lightning Flash Rate Parameterizations Based on Observations of Colorado Storms during DC3

    NASA Astrophysics Data System (ADS)

    Basarab, B.; Fuchs, B.; Rutledge, S. A.

    2013-12-01

    Predicting lightning activity in thunderstorms is important in order to accurately quantify the production of nitrogen oxides (NOx = NO + NO2) by lightning (LNOx). Lightning is an important global source of NOx, and since NOx is a chemical precursor to ozone, the climatological impacts of LNOx could be significant. Many cloud-resolving models rely on parameterizations to predict lightning and LNOx since the processes leading to charge separation and lightning discharge are not yet fully understood. This study evaluates predicted flash rates based on existing lightning parameterizations against flash rates observed for Colorado storms during the Deep Convective Clouds and Chemistry Experiment (DC3). Evaluating lightning parameterizations against storm observations is a useful way to possibly improve the prediction of flash rates and LNOx in models. Additionally, since convective storms that form in the eastern plains of Colorado can be different thermodynamically and electrically from storms in other regions, it is useful to test existing parameterizations against observations from these storms. We present an analysis of the dynamics, microphysics, and lightning characteristics of two case studies, severe storms that developed on 6 and 7 June 2012. This analysis includes dual-Doppler derived horizontal and vertical velocities, a hydrometeor identification based on polarimetric radar variables using the CSU-CHILL radar, and insight into the charge structure using observations from the northern Colorado Lightning Mapping Array (LMA). Flash rates were inferred from the LMA data using a flash counting algorithm. We have calculated various microphysical and dynamical parameters for these storms that have been used in empirical flash rate parameterizations. In particular, maximum vertical velocity has been used to predict flash rates in some cloud-resolving chemistry simulations. We diagnose flash rates for the 6 and 7 June storms using this parameterization and compare to observed flash rates. For the 6 June storm, a preliminary analysis of aircraft observations of storm inflow and outflow is presented in order to place flash rates (and other lightning statistics) in the context of storm chemistry. An approach to a possibly improved LNOx parameterization scheme using different lightning metrics such as flash area will be discussed.

  2. Flash Location, Size, and Rates Relative to the Evolving Kinematics and Microphysics of the 29 May 2012 DC3 Supercell Storm

    NASA Astrophysics Data System (ADS)

    MacGorman, D. R.; DiGangi, E.; Ziegler, C.; Biggerstaff, M. I.; Betten, D.; Bruning, E. C.

    2014-12-01

    A supercell thunderstorm was observed on 29 May 2012 during the Deep Convective Clouds and Chemistry (DC3) experiment. This storm was part of a cluster of severe storms and produced 5" hail, an EF-1 tornado, and copious lightning over the course of a few hours. During a period in which flash rates were increasing rapidly, observations were obtained from mobile polarimetric radars and a balloon-borne electric field meter (EFM) and particle imager, while aircraft sampled the chemistry of the inflow and anvil. In addition, the storm was within the domain of the 3-dimensional Oklahoma Lightning Mapping Array (LMA) and the S-band KTLX WSR-88D radar. The focus of this paper is the evolution of flash rates, the location of flash initiations, and the distribution of flash size and flash extent density as they relate to the evolving kinematics and microphysics of the storm for the approximately 30-minute period in which triple-Doppler coverage was available. Besides analyzing reflectivity structure and three-dimensional winds for the entire period, we examine mixing ratios of cloud water, cloud ice, rain, and graupel/hail that have been retrieved by a Lagrangian analysis for three select times, one each at the beginning, middle, and end of the period. Flashes in an around the updraft of this storm were typically small. Flash size tended to increase, and flash rates tended to decrease as distance from the updraft increased. Although flash initiations were most frequent near the updraft, some flashes were initiated near the edge of 30 dBZ cores and propagated into the anvil. Later, some flashes were initiated in the anvil itself, in vertical cells that formed and became electrified tens of kilometers downshear of the main body of the storm. Considerable lightning structure was inferred to be in regions dominated by cloud ice in the upper part of the storm. The continual small discharges in the overshooting top of the storm tended to be near or within 15 dBZ contours, although occasional discharges appeared to extend above the storm.

  3. Graphics performance in rich Internet applications.

    PubMed

    Hoetzlein, Rama C

    2012-01-01

    Rendering performance for rich Internet applications (RIAs) has recently focused on the debate between using Flash and HTML5 for streaming video and gaming on mobile devices. A key area not widely explored, however, is the scalability of raw bitmap graphics performance for RIAs. Does Flash render animated sprites faster than HTML5? How much faster is WebGL than Flash? Answers to these questions are essential for developing large-scale data visualizations, online games, and truly dynamic websites. A new test methodology analyzes graphics performance across RIA frameworks and browsers, revealing specific performance outliers in existing frameworks. The results point toward a future in which all online experiences might be GPU accelerated.

  4. On numerical heat transfer characteristic study of flat surface subjected to variation in geometric thickness

    NASA Astrophysics Data System (ADS)

    Umair, Siddique Mohammed; Kolawale, Abhijeet Rangnath; Bhise, Ganesh Anurath; Gulhane, Nitin Parashram

    Thermal management in the looming world of electronic packaging system is the most prior and conspicuous issue as far as the working efficiency of the system is concerned. The cooling in such systems can be achieved by impinging air jet over the heat sink as jet impingement cooling is one of the cooling technologies which are widely studied now. Here the modulation in impinging and geometric parameters results in the establishment of the characteristic cooling rate over the target surface. The characteristic cooling curve actually resembles non-uniformity in cooling rate. This non-uniformity favors the area average heat dissipation rate. In order to study the non-uniformity in cooling characteristic, the present study takes an initiative in plotting the local Nusselt number magnitude against the non-dimensional radial distance of the different thickness of target surfaces. For this, the steady temperature distribution over the target surface under the impingement of air jet is being determined numerically. The work is completely inclined towards the determination of critical value of geometric thickness below which the non-uniformity in the Nusselt profile starts. This is done by numerically examining different target surfaces under constant Reynolds number and nozzle-target spacing. The occurrences of non-uniformity in Nusselt profile contributes to over a 42% enhancement in area average Nusselt magnitude. The critical value of characteristic thickness (t/d) reported in the present investigation approximate to 0.05. Below this value, the impingement of air jet generates a discrete pressure zones over the target surface in the form of pressure spots. As a result of this, the air flowing in contact with the target surface experiences a damping potential, in due of which it gets more time and contact with the surface to dissipate heat.

  5. All-digital full waveform recording photon counting flash lidar

    NASA Astrophysics Data System (ADS)

    Grund, Christian J.; Harwit, Alex

    2010-08-01

    Current generation analog and photon counting flash lidar approaches suffer from limitation in waveform depth, dynamic range, sensitivity, false alarm rates, optical acceptance angle (f/#), optical and electronic cross talk, and pixel density. To address these issues Ball Aerospace is developing a new approach to flash lidar that employs direct coupling of a photocathode and microchannel plate front end to a high-speed, pipelined, all-digital Read Out Integrated Circuit (ROIC) to achieve photon-counting temporal waveform capture in each pixel on each laser return pulse. A unique characteristic is the absence of performance-limiting analog or mixed signal components. When implemented in 65nm CMOS technology, the Ball Intensified Imaging Photon Counting (I2PC) flash lidar FPA technology can record up to 300 photon arrivals in each pixel with 100 ps resolution on each photon return, with up to 6000 range bins in each pixel. The architecture supports near 100% fill factor and fast optical system designs (f/#<1), and array sizes to 3000×3000 pixels. Compared to existing technologies, >60 dB ultimate dynamic range improvement, and >104 reductions in false alarm rates are anticipated, while achieving single photon range precision better than 1cm. I2PC significantly extends long-range and low-power hard target imaging capabilities useful for autonomous hazard avoidance (ALHAT), navigation, imaging vibrometry, and inspection applications, and enables scannerless 3D imaging for distributed target applications such as range-resolved atmospheric remote sensing, vegetation canopies, and camouflage penetration from terrestrial, airborne, GEO, and LEO platforms. We discuss the I2PC architecture, development status, anticipated performance advantages, and limitations.

  6. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bond, Evelyn M.; Moody, W. Allen; Arnold, Charles

    Here, the preparation of 191Ir and 193Ir electrodeposits for neutron capture cross-section measurements at the detector for advanced neutron capture experiments located at the at Los Alamos Neutron Science Center is described. The electrodeposition of iridium in the desired thickness of 0.4–1 mg/cm 2 is challenging. Better yields and thicknesses were obtained using electrodeposition from isopropyl alcohol solutions than from ammonium sulfate solutions. 191Ir and 193Ir targets were initially prepared using the standard single-sided electrodeposition cell. Iridium electrodepositions using a double-sided electrodeposition cell were developed and were optimized, resulting in thick, uniform iridium deposits. LA UR 15-22475.

  7. Inductive voltage adder advanced hydrodynamic radiographic technology demonstration

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mazarakis, M.G.; Poukey, J.W.; Maenchen

    This paper presents the design, results, and analysis of a high-brightness electron beam technology demonstration experiment completed at Sandia National Laboratories, performed in collaboration with Los Alamos National Laboratory. The anticipated electron beam parameters were: 12 MeV, 35-40 kA, 0.5-mm rms radius, and 40-ns full width half maximum (FWHM) pulse duration. This beam, on an optimum thickness tantalum converter, should produce a very intense x-ray source of {approximately} 1.5-mm spot size and 1 kR dose @ 1 m. The accelerator utilized was SABRE, a pulsed inductive voltage adder, and the electron source was a magnetically immersed foilless electron diode. Formore » these experiments, SABRE was modified to high-impedance negative-polarity operation. A new 100-ohm magnetically insulated transmission line cathode electrode was designed and constructed; the cavities were rotated 180{degrees} poloidally to invert the central electrode polarity to negative; and only one of the two pulse forming lines per cavity was energized. A twenty- to thirty-Tesla solenoidal magnet insulated the diode and contained the beam at its extremely small size. These experiments were designed to demonstrate high electron currents in submillimeter radius beams resulting in a high-brightness high-intensity flash x-ray source for high-resolution thick-object hydrodynamic radiography. The SABRE facility high-impedance performance was less than what was hoped. The modifications resulted in a lower amplitude (9 MV), narrower-than-anticipated triangular voltage pulse, which limited the dose to {approximately} 20% of the expected value. In addition, halo and ion-hose instabilities increased the electron beam spot size to > 1.5 mm. Subsequent, more detailed calculations explain these reduced output parameters. An accelerator designed (versus retrofit) for this purpose would provide the desired voltage and pulse shape.« less

  8. Influence of the geometry of protective barriers on the propagation of shock waves

    NASA Astrophysics Data System (ADS)

    Sochet, I.; Eveillard, S.; Vinçont, J. Y.; Piserchia, P. F.; Rocourt, X.

    2017-03-01

    The protection of industrial facilities, classified as hazardous, against accidental or intentional explosions represents a major challenge for the prevention of personal injury and property damage, which also involves social and economic issues. We consider here the use of physical barriers against the effects of these explosions, which include the pressure wave, the projection of fragments and the thermal flash. This approach can be recommended for the control of major industrial risks, but no specific instructions are available for its implementation. The influence of a protective barrier against a detonation-type explosion is studied in small-scale experiments. The effects of overpressure are examined over the entire path of the shock wave across the barrier and in the downstream zone to be protected. Two series of barrier structures are studied. The first series (A) of experiments investigates two types of barrier geometry with dimensions based on NATO recommendations. These recommendations stipulate that the barrier should be 2 m higher than the charge height, the thickness at the crest should be more than 0.5 m, while its length should be equal to twice the protected structure length and the bank slope should be equivalent to the angle of repose of the soil. The second series (B) of experiments investigates the influence of geometrical parameters of the barrier (thickness at the crest and inclination angles of the front and rear faces) on its protective effects. This project leads to an advance in our understanding of the physical phenomena involved in the propagation of blast waves resulting from an external explosion, in the area around a protective physical barrier. The study focuses on the dimensioning of protective barriers against overpressure effects arising from detonation and shows the advantage of using a barrier with a vertical front or rear face.

  9. Projectile-target mixing in melted ejecta formed during a hypervelocity impact cratering event

    NASA Technical Reports Server (NTRS)

    Evans, Noreen Joyce; Ahrens, Thomas J.; Shahinpoor, M.; Anderson, W. W.

    1993-01-01

    Tektites contain little to no projectile contamination while, in contrast, some distal ejecta deposits can be relatively projectile-rich (e.g. the Cretaceous-Tertiary (K-T) boundary clay). This compositional difference motivated an experimental study of hypervelocity target-projectile mixing processes. We hope to scale up the results from these experiments and apply them to terrestrial impact structures like the Chicxulub Crater, Yucutan, Mexico, the leading contender as the site for the impact that caused the mass extinction that marks the K-T boundary. Shock decomposition of the approximately 500m thickness of anhydrite, or greater thickness of limestone, in the target rocks at Chicxulub may have been a critical mechanism for either global cooling via SO3, and subsequently H2SO4, formation, or possibly, global warming via increased CO2 formation. Understanding target-projectile mixing processes during hypervelocity impact may permit more accurate estimates of the amount of potentially toxic, target-derived material reaching stratospheric heights.

  10. Direct observation of feedout-related areal mass oscillations in planar plastic targets.

    NASA Astrophysics Data System (ADS)

    Aglitskiy, Y.; Metzler, N.; Velikovich, A. L.; Karasik, M.; Serlin, V.; Pawley, C.; Mostovych, A. N.; Schmitt, A. J.; Obenschain, S. P.; Gardner, J. H.

    2001-10-01

    "Feedout" means the transfer of mass perturbations from the rear to the front surface of a driven target. The oscillations are expected if the perturbation wavelength λ is not large compared to 2π L_s, where Ls is the shock-compressed target thickness. We report the first direct experimental observation of areal mass oscillation associated with feedout, followed by the onset of exponential RT growth. Our experiments were performed with the Nike KrF laser at irradiation 50 TW/cm^2. The mass redistribution in the target was observed with the aid of monochromatic x-ray imaging coupled to a streak camera. We used 40 to 60 μm thick CH targets rippled on the rear side with wavelengths of either 30 or 45 μm, the ratio 2π L_s/λ thus being close to 2. Two phase reversals of mass variation predicted by the theory and simulations were consistently observed both on the original images and on the time histories of Fourier amplitudes.

  11. Polar-direct-drive experiments with contoured-shell targets on OMEGA

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Marshall, F. J.; Radha, P. B.; Bonino, M. J.

    Polar-driven direct-drive experiments recently performed on the OMEGA Laser System have demonstrated the efficacy of using a target with a contoured shell with varying thickness to improve the symmetry and fusion performance of the implosion. The polar-driven contoured-shell implosions have substantially reduced low mode perturbations compared to polar-driven spherical-shell implosions as diagnosed by x-ray radiographs up to shell stagnation. As a result, fusion yields were increased by more than a factor of ~2 without increasing the energy of the laser by the use of contoured shells.

  12. Polar-direct-drive experiments with contoured-shell targets on OMEGA

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Marshall, F. J.; Radha, P. B.; Bonino, M. J.

    Polar-driven direct-drive experiments recently performed on the OMEGA Laser System have demonstrated the efficacy of using a target with a contoured shell with varying thickness to improve the symmetry and fusion performance of the implosion. The polar-driven contoured-shell implosions have substantially reduced low mode perturbations compared to polar-driven spherical-shell implosions as diagnosed by x-ray radiographs up to shell stagnation. Fusion yields were increased by more than a factor of ∼2 without increasing the energy of the laser by the use of contoured shells.

  13. Polar-direct-drive experiments with contoured-shell targets on OMEGA

    DOE PAGES

    Marshall, F. J.; Radha, P. B.; Bonino, M. J.; ...

    2016-01-28

    Polar-driven direct-drive experiments recently performed on the OMEGA Laser System have demonstrated the efficacy of using a target with a contoured shell with varying thickness to improve the symmetry and fusion performance of the implosion. The polar-driven contoured-shell implosions have substantially reduced low mode perturbations compared to polar-driven spherical-shell implosions as diagnosed by x-ray radiographs up to shell stagnation. As a result, fusion yields were increased by more than a factor of ~2 without increasing the energy of the laser by the use of contoured shells.

  14. Pushing the P300-based brain-computer interface beyond 100 bpm: extending performance guided constraints into the temporal domain.

    PubMed

    Townsend, G; Platsko, V

    2016-04-01

    A new presentation paradigm for the P300-based brain-computer interface (BCI) referred to as the 'asynchronous paradigm' (ASP) is introduced and studied. It is based on the principle of performance guided constraints (Townsend et al 2012 Neurosci. Lett. 531 63-8) extended from the spatial domain into the temporal domain. The traditional constraint of flashing targets in predefined constant epochs of time is eliminated and targets flash asynchronously with timing based instead on constraints intended to improve performance. We propose appropriate temporal constraints to derive the ASP and compare its performance to that of the 'checkerboard paradigm' (CBP), which has previously been shown to be superior to the standard 'row/column paradigm' introduced by Farwell and Donchin (1988 Electroencephalogr. Clin. Neurophysiol. 70 510-23). Ten participants were tested in the ASP and CBP conditions both with traditional flashing items and with flashing faces in place of the targets (see Zhang et al 2012 J. Neural Eng. 9 026018; Kaufmann and Kübler 2014 J. Neural Eng. 11 ; Chen et al 2015 J. Neurosci. Methods 239 18-27). Eleven minutes of calibration data were used as input to a stepwise linear discriminant analysis to derive classification coefficients used for online classification. Accuracy was consistently high for both paradigms (87% and 93%) while information transfer rate was 45% higher for the ASP than the CBP. In a free spelling task, one subject spelled a 66 character sentence (from a 72 item matrix) with 100% accuracy in 3 min and 24 s demonstrating a practical throughput of 120 bits per minute (bpm) with a theoretical upper bound of 258 bpm. The subject repeated the task three times in a row without error. This work represents an advance in P300 speller technology and raises the ceiling that was being reached on P300-based BCIs. Most importantly, the research presented here is a novel and effective general strategy for organising timing for flashing items. The ASP is only one possible implementation of this work since in general it can be used to describe all previous existing presentation paradigms as well as any possible new ones. This may be especially important for people with neuromuscular disabilities.

  15. Development of IR Contrast Data Analysis Application for Characterizing Delaminations in Graphite-Epoxy Structures

    NASA Technical Reports Server (NTRS)

    Havican, Marie

    2012-01-01

    Objective: Develop infrared (IR) flash thermography application based on use of a calibration standard for inspecting graphite-epoxy laminated/honeycomb structures. Background: Graphite/Epoxy composites (laminated and honeycomb) are widely used on NASA programs. Composite materials are susceptible for impact damage that is not readily detected by visual inspection. IR inspection can provide required sensitivity to detect surface damage in composites during manufacturing and during service. IR contrast analysis can provide characterization of depth, size and gap thickness of impact damage. Benefits/Payoffs: The research provides an empirical method of calibrating the flash thermography response in nondestructive evaluation. A physical calibration standard with artificial flaws such as flat bottom holes with desired diameter and depth values in a desired material is used in calibration. The research devises several probability of detection (POD) analysis approaches to enable cost effective POD study to meet program requirements.

  16. Systems-wide RNAi analysis of CASP8AP2/FLASH shows transcriptional deregulation of the replication-dependent histone genes and extensive effects on the transcriptome of colorectal cancer cells

    PubMed Central

    2012-01-01

    Background Colorectal carcinomas (CRC) carry massive genetic and transcriptional alterations that influence multiple cellular pathways. The study of proteins whose loss-of-function (LOF) alters the growth of CRC cells can be used to further understand the cellular processes cancer cells depend upon for survival. Results A small-scale RNAi screen of ~400 genes conducted in SW480 CRC cells identified several candidate genes as required for the viability of CRC cells, most prominently CASP8AP2/FLASH. To understand the function of this gene in maintaining the viability of CRC cells in an unbiased manner, we generated gene specific expression profiles following RNAi. Silencing of CASP8AP2/FLASH resulted in altered expression of over 2500 genes enriched for genes associated with cellular growth and proliferation. Loss of CASP8AP2/FLASH function was significantly associated with altered transcription of the genes encoding the replication-dependent histone proteins as a result of the expression of the non-canonical polyA variants of these transcripts. Silencing of CASP8AP2/FLASH also mediated enrichment of changes in the expression of targets of the NFκB and MYC transcription factors. These findings were confirmed by whole transcriptome analysis of CASP8AP2/FLASH silenced cells at multiple time points. Finally, we identified and validated that CASP8AP2/FLASH LOF increases the expression of neurofilament heavy polypeptide (NEFH), a protein recently linked to regulation of the AKT1/ß-catenin pathway. Conclusions We have used unbiased RNAi based approaches to identify and characterize the function of CASP8AP2/FLASH, a protein not previously reported as required for cell survival. This study further defines the role CASP8AP2/FLASH plays in the regulating expression of the replication-dependent histones and shows that its LOF results in broad and reproducible effects on the transcriptome of colorectal cancer cells including the induction of expression of the recently described tumor suppressor gene NEFH. PMID:22216762

  17. Systems-wide RNAi analysis of CASP8AP2/FLASH shows transcriptional deregulation of the replication-dependent histone genes and extensive effects on the transcriptome of colorectal cancer cells.

    PubMed

    Hummon, Amanda B; Pitt, Jason J; Camps, Jordi; Emons, Georg; Skube, Susan B; Huppi, Konrad; Jones, Tamara L; Beissbarth, Tim; Kramer, Frank; Grade, Marian; Difilippantonio, Michael J; Ried, Thomas; Caplen, Natasha J

    2012-01-04

    Colorectal carcinomas (CRC) carry massive genetic and transcriptional alterations that influence multiple cellular pathways. The study of proteins whose loss-of-function (LOF) alters the growth of CRC cells can be used to further understand the cellular processes cancer cells depend upon for survival. A small-scale RNAi screen of ~400 genes conducted in SW480 CRC cells identified several candidate genes as required for the viability of CRC cells, most prominently CASP8AP2/FLASH. To understand the function of this gene in maintaining the viability of CRC cells in an unbiased manner, we generated gene specific expression profiles following RNAi. Silencing of CASP8AP2/FLASH resulted in altered expression of over 2500 genes enriched for genes associated with cellular growth and proliferation. Loss of CASP8AP2/FLASH function was significantly associated with altered transcription of the genes encoding the replication-dependent histone proteins as a result of the expression of the non-canonical polyA variants of these transcripts. Silencing of CASP8AP2/FLASH also mediated enrichment of changes in the expression of targets of the NFκB and MYC transcription factors. These findings were confirmed by whole transcriptome analysis of CASP8AP2/FLASH silenced cells at multiple time points. Finally, we identified and validated that CASP8AP2/FLASH LOF increases the expression of neurofilament heavy polypeptide (NEFH), a protein recently linked to regulation of the AKT1/ß-catenin pathway. We have used unbiased RNAi based approaches to identify and characterize the function of CASP8AP2/FLASH, a protein not previously reported as required for cell survival. This study further defines the role CASP8AP2/FLASH plays in the regulating expression of the replication-dependent histones and shows that its LOF results in broad and reproducible effects on the transcriptome of colorectal cancer cells including the induction of expression of the recently described tumor suppressor gene NEFH.

  18. Observations of Stratiform Lightning Flashes and Their Microphysical and Kinematic Environments

    NASA Technical Reports Server (NTRS)

    Lang, Timothy J.; Williams, Earle

    2016-01-01

    During the Midlatitude Continental Convective Clouds Experiment (MC3E), combined observations of clouds and precipitation were made from airborne and ground-based in situ and remote sensing platforms. These observations were coordinated for multiple mesoscale convective systems (MCSs) that passed over the MC3E domain in northern Oklahoma. Notably, during a storm on 20 May 2011 in situ and remote sensing airborne observations were made near the times and locations of stratiform positive cloud-to-ground (+CG) lightning flashes. These +CGs resulted from extremely large stratiform lightning flashes that were hundreds of km in length and lasted several seconds. This dataset provides an unprecedented look at kinematic and microphysical environments in the vicinity of large, powerful, and long-lived stratiform lightning flashes. We will use this dataset to understand the influence of low liquid water contents (LWCs) in the electrical charging of MCS stratiform regions.

  19. Observations of Stratiform Lightning Flashes and Their Microphysical and Kinematic Environments

    NASA Technical Reports Server (NTRS)

    Lang, Timothy J.; Williams, Earle

    2017-01-01

    During the Midlatitude Continental Convective Clouds Experiment (MC3E), combined observations of clouds and precipitation were made from airborne and ground-based in situ and remote sensing platforms. These observations were coordinated for multiple mesoscale convective systems (MCSs) that passed over the MC3E domain in northern Oklahoma. Notably, during a storm on 20 May 2011 in situ and remote sensing airborne observations were made near the times and locations of stratiform positive cloud-to-ground (+CG) lightning flashes. These +CGs resulted from extremely large stratiform lightning flashes that were hundreds of km in length and lasted several seconds. This dataset provides an unprecedented look at kinematic and microphysical environments in the vicinity of large, powerful, and long-lived stratiform lightning flashes. We will use this dataset to understand the influence of low liquid water contents (LWCs) in the electrical charging of MCS stratiform regions.

  20. Models for Total-Dose Radiation Effects in Non-Volatile Memory

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Campbell, Philip Montgomery; Wix, Steven D.

    The objective of this work is to develop models to predict radiation effects in non- volatile memory: flash memory and ferroelectric RAM. In flash memory experiments have found that the internal high-voltage generators (charge pumps) are the most sensitive to radiation damage. Models are presented for radiation effects in charge pumps that demonstrate the experimental results. Floating gate models are developed for the memory cell in two types of flash memory devices by Intel and Samsung. These models utilize Fowler-Nordheim tunneling and hot electron injection to charge and erase the floating gate. Erase times are calculated from the models andmore » compared with experimental results for different radiation doses. FRAM is less sensitive to radiation than flash memory, but measurements show that above 100 Krad FRAM suffers from a large increase in leakage current. A model for this effect is developed which compares closely with the measurements.« less

  1. Correlation of individual cosmic ray nuclei with the observation of light flashes by Apollo astronauts. [nuclear emulsion detector design and operation

    NASA Technical Reports Server (NTRS)

    Pinsky, L. S.; Osborne, W. Z.; Bailey, J. V.

    1975-01-01

    A nuclear emulsion detector known as the Apollo Light Flash Moving Emulsion Detector (ALFMED) was designed: (1) to record tracks of primary cosmic rays; (2) to provide time-of-passage information via a relative plate translation technique; (3) to provide particle trajectory information; and (4) to fit into a masklike device that could be located about the head and eyes of an astronaut. An ALFMED device was worn by an astronaut observing light flashes for 60 minutes on each of the last two Apollo missions. During the Apollo 17 experiment seventeen separate flashes were reported by the observer. With one-third of the total plate area completely analyzed, two definite correlations have been found between Z greater than 8 cosmic ray nuclei traversing an eye and the reports of visual sensations.

  2. Timing in a FLASH

    NASA Astrophysics Data System (ADS)

    Hoek, M.; Cardinali, M.; Corell, O.; Dickescheid, M.; Ferretti B., M. I.; Lauth, W.; Schlimme, B. S.; Sfienti, C.; Thiel, M.

    2017-12-01

    A prototype detector, called FLASH (Fast Light Acquiring Start Hodoscope), was built to provide precise Time-of-Flight (TOF) measurements and reference timestamps for detector setups at external beam lines. Radiator bars, made of synthetic fused silica, were coupled to a fast MCP-PMT with 64 channels and read out with custom electronics using Time-over-Threshold (TOT) for signal characterization. The TRB3 system, a high-precision TDC implemented in an FPGA, was used as data acquisition system. The performance of a system consisting of two FLASH units was investigated at a dedicated test experiment at the Mainz Microtron (MAMI) accelerator using its 855 MeV electron beam. The TOT measurement enabled time walk corrections and an overall TOF resolution of ∼70 ps could be achieved which translates into a resolution of ∼50 ps per FLASH unit. The intrinsic resolution of the frontend electronics including the TDC was measured to be less than 25 ps.

  3. Target switching in curved human arm movements is predicted by changing a single control parameter.

    PubMed

    Hoffmann, Heiko

    2011-01-01

    Straight-line movements have been studied extensively in the human motor-control literature, but little is known about how to generate curved movements and how to adjust them in a dynamic environment. The present work studied, for the first time to my knowledge, how humans adjust curved hand movements to a target that switches location. Subjects (n = 8) sat in front of a drawing tablet and looked at a screen. They moved a cursor on a curved trajectory (spiral or oval shaped) toward a goal point. In half of the trials, this goal switched 200 ms after movement onset to either one of two alternative positions, and subjects smoothly adjusted their movements to the new goal. To explain this adjustment, we compared three computational models: a superposition of curved and minimum-jerk movements (Flash and Henis in J Cogn Neurosci 3(3):220-230, 1991), Vector Planning (Gordon et al. in Exp Brain Res 99(1):97-111, 1994) adapted to curved movements (Rescale), and a nonlinear dynamical system, which could generate arbitrarily curved smooth movements and had a point attractor at the goal. For each model, we predicted the trajectory adjustment to the target switch by changing only the goal position in the model. As result, the dynamical model could explain the observed switch behavior significantly better than the two alternative models (spiral: P = 0.0002 vs. Flash, P = 0.002 vs. Rescale; oval: P = 0.04 vs. Flash; P values obtained from Wilcoxon test on R (2) values). We conclude that generalizing arbitrary hand trajectories to new targets may be explained by switching a single control command, without the need to re-plan or re-optimize the whole movement or superimpose movements.

  4. 3-D Modeling of Planar Target-Mount Perturbation Experiments on OMEGA

    NASA Astrophysics Data System (ADS)

    Collins, T. J. B.; Marshall, F. J.; Marozas, J. A.; Bonino, M. J.; Forties, R.; Goncharov, V. N.; Igumenshchev, I. V.; McKenty, P. W.; Smalyuk, V. A.

    2008-11-01

    OMEGA cryogenic targets are suspended in the target chamber using four spider silks attached to a C-shaped mount. The spider silks are typically composed of two entwined protein strands comparable to 1 μm in diameter. The silks and mount refract the incident laser light and cast shadows on the target surface. Experiments to measure the effects of the silks on target illumination have been performed in planar geometry using silks suspended parallel to a 20-μm-thick laser-driven target. The evolution of the surface perturbations introduced by the silks was measured using x-ray backlighting. The results of these experiments will be compared to simulations performed with DRACO, employing three-dimensional (3-D) planar hydrodynamics and a new 3-D refractive ray-trace package written specifically for this geometry. This work was supported by the U.S. Department of Energy Office of Inertial Confinement Fusion under Cooperative Agreement No. DE-FC52-08NA28302.

  5. First internal and external experiments at COSY Juelich

    NASA Astrophysics Data System (ADS)

    Prasuhn, D.; Maier, R.; Bechstedt, U.; Dietrich, J.; Hacker, U.; Martin, S.; Stockhorst, H.; Tölle, R.; Grzonka, D.; Nake, C.; Mosel, F.

    1995-02-01

    The inauguration of the cooler synchrotron COSY Jülich was celebrated on April 1st, 1993. After the first successful acceleration to proton momenta above 800 GeV/ c, beamtimes for experiments were scheduled in parallel to further machine development. The first experiment was the internal target experiment EDDA, which investigated the energy dependence of the p-p interaction. It makes use of a 3 × 4 μm 2 thin CH 2 fiber as an internal target. The thickness of the fiber is more than adequate to achieve high luminosities, so the intensity of the stored beam has to be reduced to 10 7 p. On the other hand, it is thin enough to achieve beam lifetimes of 3 s at 1.4 GeV/ c. Details of the target fabrication and the first experimental results will be discussed. Both external experimental facilities at COSY, the time-of-flight spectrometer, and the magnetic spectrometer BIG KARL use a liquid hydrogen (deuterium) target. The first experiments were carried out at proton energies between 300 MeV and 500 MeV. Also, these experimental data will be presented. Two further internal experiments are prepared for the installation into the COSY ring. The target for the first experiment is a gas-jet target, the second experiment uses ribbon targets for the interaction. The status of both experimental setups will be shown.

  6. Impact of ablator thickness and laser drive duration on a platform for supersonic, shockwave-driven hydrodynamic instability experiments

    DOE PAGES

    Wan, W. C.; Malamud, Guy; Shimony, A.; ...

    2016-12-07

    Here, we discuss changes to a target design that improved the quality and consistency of data obtained through a novel experimental platform that enables the study of hydrodynamic instabilities in a compressible regime. The experiment uses a laser to drive steady, supersonic shockwave over well-characterized initial perturbations. Early experiments were adversely affected by inadequate experimental timescales and, potentially, an unintended secondary shockwave. These issues were addressed by extending the 4 x 10 13 W/cm 2 laser pulse from 19 ns to 28 ns, and increasing the ablator thickness from 185 µm to 500 µm. We present data demonstrating the performancemore » of the platform.« less

  7. Impact of ablator thickness and laser drive duration on a platform for supersonic, shockwave-driven hydrodynamic instability experiments

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wan, W. C.; Malamud, Guy; Shimony, A.

    Here, we discuss changes to a target design that improved the quality and consistency of data obtained through a novel experimental platform that enables the study of hydrodynamic instabilities in a compressible regime. The experiment uses a laser to drive steady, supersonic shockwave over well-characterized initial perturbations. Early experiments were adversely affected by inadequate experimental timescales and, potentially, an unintended secondary shockwave. These issues were addressed by extending the 4 x 10 13 W/cm 2 laser pulse from 19 ns to 28 ns, and increasing the ablator thickness from 185 µm to 500 µm. We present data demonstrating the performancemore » of the platform.« less

  8. Laser beam-profile impression and target thickness impact on laser-accelerated protons

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Schollmeier, M.; Harres, K.; Nuernberg, F.

    Experimental results on the influence of the laser focal spot shape onto the beam profile of laser-accelerated protons from gold foils are reported. The targets' microgrooved rear side, together with a stack of radiochromic films, allowed us to deduce the energy-dependent proton source-shape and size, respectively. The experiments show, that shape and size of the proton source depend only weakly on target thickness as well as shape of the laser focus, although they strongly influence the proton's intensity distribution. It was shown that the laser creates an electron beam that closely follows the laser beam topology, which is maintained duringmore » the propagation through the target. Protons are then accelerated from the rear side with an electron created electric field of a similar shape. Simulations with the Sheath-Accelerated Beam Ray-tracing for IoN Analysis code SABRINA, which calculates the proton distribution in the detector for a given laser-beam profile, show that the electron distribution during the transport through a thick target (50 {mu}m Au) is only modified due to multiple small angle scattering. Thin targets (10 {mu}m) show large source sizes of over 100 {mu}m diameter for 5 MeV protons, which cannot be explained by multiple scattering only and are most likely the result of refluxing electrons.« less

  9. Cryogenic Target-Implosion Experiments on OMEGA

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Harding, D.R.; Meyerhofer, D.D.; Sangster, T.C.

    The University of Rochester’s Laboratory for Laser Energetics has been imploding thick cryogenic targets for six years. Improvements in the Cryogenic Target Handling System and the ability to accurately design laser pulse shapes that properly time shocks and minimize electron preheat, produced high fuel areal densities in deuterium cryogenic targets (202+/-7 mg/cm^2). The areal density was inferred from the energy loss of secondary protons in the fuel (D2) shell. Targets were driven on a low final adiabat (alpha = 2) employing techniques to radially grade the adiabat (the highest adiabat at the ablation surface). The ice layer meets the target-designmore » toughness specification for DT ice of 1-um rms (all modes), while D2 ice layers average 3.0-um-rms roughness. The implosion experiments and the improvements in the quality and understanding of cryogenic targets are presented.« less

  10. Presentation and response timing accuracy in Adobe Flash and HTML5/JavaScript Web experiments.

    PubMed

    Reimers, Stian; Stewart, Neil

    2015-06-01

    Web-based research is becoming ubiquitous in the behavioral sciences, facilitated by convenient, readily available participant pools and relatively straightforward ways of running experiments: most recently, through the development of the HTML5 standard. Although in most studies participants give untimed responses, there is a growing interest in being able to record response times online. Existing data on the accuracy and cross-machine variability of online timing measures are limited, and generally they have compared behavioral data gathered on the Web with similar data gathered in the lab. For this article, we took a more direct approach, examining two ways of running experiments online-Adobe Flash and HTML5 with CSS3 and JavaScript-across 19 different computer systems. We used specialist hardware to measure stimulus display durations and to generate precise response times to visual stimuli in order to assess measurement accuracy, examining effects of duration, browser, and system-to-system variability (such as across different Windows versions), as well as effects of processing power and graphics capability. We found that (a) Flash and JavaScript's presentation and response time measurement accuracy are similar; (b) within-system variability is generally small, even in low-powered machines under high load; (c) the variability of measured response times across systems is somewhat larger; and (d) browser type and system hardware appear to have relatively small effects on measured response times. Modeling of the effects of this technical variability suggests that for most within- and between-subjects experiments, Flash and JavaScript can both be used to accurately detect differences in response times across conditions. Concerns are, however, noted about using some correlational or longitudinal designs online.

  11. Imaging Flash Lidar for Autonomous Safe Landing and Spacecraft Proximity Operation

    NASA Technical Reports Server (NTRS)

    Amzajerdian, Farzin; Roback, Vincent E.; Brewster, Paul F.; Hines, Glenn D.; Bulyshev, Alexander E.

    2016-01-01

    3-D Imaging flash lidar is recognized as a primary candidate sensor for safe precision landing on solar system bodies (Moon, Mars, Jupiter and Saturn moons, etc.), and autonomous rendezvous proximity operations and docking/capture necessary for asteroid sample return and redirect missions, spacecraft docking, satellite servicing, and space debris removal. During the final stages of landing, from about 1 km to 500 m above the ground, the flash lidar can generate 3-Dimensional images of the terrain to identify hazardous features such as craters, rocks, and steep slopes. The onboard fli1ght computer can then use the 3-D map of terrain to guide the vehicle to a safe location. As an automated rendezvous and docking sensor, the flash lidar can provide relative range, velocity, and bearing from an approaching spacecraft to another spacecraft or a space station from several kilometers distance. NASA Langley Research Center has developed and demonstrated a flash lidar sensor system capable of generating 16k pixels range images with 7 cm precision, at a 20 Hz frame rate, from a maximum slant range of 1800 m from the target area. This paper describes the lidar instrument design and capabilities as demonstrated by the closed-loop flight tests onboard a rocket-propelled free-flyer vehicle (Morpheus). Then a plan for continued advancement of the flash lidar technology will be explained. This proposed plan is aimed at the development of a common sensor that with a modest design adjustment can meet the needs of both landing and proximity operation and docking applications.

  12. Inner surface flash-over of insulator of low-inductance high-voltage self-breakdown gas switch and its application

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhang, Hong-bo, E-mail: walkman67@163.com; Liu, Jin-liang

    2014-04-15

    In this paper, the inner surface flash-over of high-voltage self-breakdown switch, which is used as a main switch of pulse modulator, is analyzed in theory by employing the method of distributed element equivalent circuit. Moreover, the field distortion of the switch is simulated by using software. The results of theoretical analysis and simulation by software show that the inner surface flash-over usually starts at the junction points among the stainless steel, insulator, and insulation gas in the switch. A switch with improved structure is designed and fabricated according to the theoretical analysis and simulation results. Several methods to avoid innermore » surface flash-over are used to improve the structure of switch. In experiment, the inductance of the switch is no more than 100 nH, the working voltage of the switch is about 600 kV, and the output voltage and current of the accelerator is about 500 kV and 50 kA, respectively. And the zero-to-peak rise time of output voltage at matched load is less than 30 ns due to the small inductance of switch. The original switch was broken-down after dozens of experiments, and the improved switch has been worked more than 200 times stably.« less

  13. Relation between film character and wafer alignment: critical alignment issues on HV device for VLSI manufacturing

    NASA Astrophysics Data System (ADS)

    Lo, Yi-Chuan; Lee, Chih-Hsiung; Lin, Hsun-Peng; Peng, Chiou-Shian

    1998-06-01

    Several continuous splits for wafer alignment target topography conditions to improve epitaxy film alignment were applied. The alignment evaluation among former layer pad oxide thickness (250 angstrom - 500 angstrom), drive oxide thickness (6000 angstrom - 10000 angstrom), nitride film thickness (600 angstrom - 1500 angstrom), initial oxide etch (fully wet etch, fully dry etch and dry plus wet etch) will be split to this experiment. Also various epitaxy deposition recipe such as: epitaxy source (SiHCl2 or SiCHCl3) and growth rate (1.3 micrometer/min approximately 2.0 micrometer/min) will be used to optimize the process window for alignment issue. All the reflectance signal and cross section photography of alignment target during NIKON stepper alignment process will be examined. Experimental results show epitaxy recipe plays an important role to wafer alignment. Low growth rate with good performance conformity epitaxy lead to alignment target avoid washout, pattern shift and distortion. All the results (signal monitor and film character) combined with NIKON's stepper standard laser scanning alignment system will be discussed in this paper.

  14. Summary of experimental studies, at CERN, on a positron source using crystal effects

    NASA Astrophysics Data System (ADS)

    Artru, X.; Baier, V.; Beloborodov, K.; Bogdanov, A.; Bukin, A.; Burdin, S.; Chehab, R.; Chevallier, M.; Cizeron, R.; Dauvergne, D.; Dimova, T.; Druzhinin, V.; Dubrovin, M.; Gatignon, L.; Golubev, V.; Jejcic, A.; Keppler, P.; Kirsch, R.; Kulibaba, V.; Lautesse, Ph.; Major, J.; Poizat, J.-C.; Potylitsin, A.; Remillieux, J.; Serednyakov, S.; Shary, V.; Strakhovenko, V.; Sylvia, C.

    2005-11-01

    A new kind of positron sources for future linear colliders, where the converter is an aligned tungsten crystal, oriented on the <1 1 1>-axis, has been studied at CERN in the WA103 experiment with tertiary electron beams from the SPS. In such sources the photons resulting from channeling radiation and coherent bremsstrahlung create the e+e- pairs. Electron beams, of 6 and 10 GeV, were impinging on different kinds of targets: a 4 mm thick crystal, a 8 mm thick crystal and a compound target made of 4 mm crystal followed by 4 mm amorphous disk. An amorphous tungsten target 20 mm thick was also used for the sake of comparison with the 8 mm crystal and to check the ability of the detection system to provide the correct track reconstruction. The charged particles coming out from the target were detected in a drift chamber immersed partially in a magnetic field. The reconstruction of the particle trajectories provided the energy and angular spectrum of the positrons in a rather wide energy range (up to 150 MeV) and angular domain (up to 30°). The experimental approach presented in this article provides a full description of this kind of source. A presentation of the measured positron distribution in momentum space (longitudinal versus transverse) is given to allow an easy determination of the available yield for a given momentum acceptance. Results on photons, measured downstream of the positron detector, are also presented. A significant enhancement of photon and positron production is clearly observed. This enhancement, for a 10 GeV incident beam, is of 4 for the 4 mm thick crystal and larger than 2 for the 8 mm thick crystal. Another important result concerns the validation of the simulations for the crystals, for which a quite good agreement was met between the simulations and the experiment, for positrons as well as for photons. These results are presented after a short presentation of the experimental setup and of the track reconstruction procedure.

  15. Apollo-Soyuz pamphlet no. 6: Cosmic ray dosage. [experimental designiradiation hazards and dosage

    NASA Technical Reports Server (NTRS)

    Page, L. W.; From, T. P.

    1977-01-01

    The radiation hazard inside spacecraft is discussed with emphasis on its effects on the crew, biological specimens, and spacecraft instruments. The problem of light flash sensations in the eyes of astronauts is addressed and experiment MA-106 is described. In this experiment, light flashes seen by blindfolded astronauts were counted and high energy cosmic ray intensity in the command module cabin were measured. The damage caused by cosmic ray hits on small living organisms was investigated in the Biostack 3 experiment (MA-107). Individual cosmic rays were tracked through layers of bacterial spores, small seeds, and eggs interleaved with layers of AgCl-crystal wafers, special plastic, and special photographic film that registered each cosmic ray particle passed.

  16. An improved P300 pattern in BCI to catch user’s attention

    NASA Astrophysics Data System (ADS)

    Jin, Jing; Zhang, Hanhan; Daly, Ian; Wang, Xingyu; Cichocki, Andrzej

    2017-06-01

    Objective. Brain-computer interfaces (BCIs) can help patients who have lost control over most muscles but are still conscious and able to communicate or interact with the environment. One of the most popular types of BCI is the P300-based BCI. With this BCI, users are asked to count the number of appearances of target stimuli in an experiment. To date, the majority of visual P300-based BCI systems developed have used the same character or picture as the target for every stimulus presentation, which can bore users. Consequently, users attention may decrease or be negatively affected by adjacent stimuli. Approach. In this study, a new stimulus is presented to increase user concentration. Honeycomb-shaped figures with 1-3 red dots were used as stimuli. The number and the positions of the red dots in the honeycomb-shaped figure were randomly changed during BCI control. The user was asked to count the number of the dots presented in each flash instead of the number of times they flashed. To assess the performance of this new stimulus, another honeycomb-shaped stimulus, without red dots, was used as a control condition. Main results. The results showed that the honeycomb-shaped stimuli with red dots obtained significantly higher classification accuracies and information transfer rates (p  <  0.05) compared to the honeycomb-shaped stimulus without red dots. Significance. The results indicate that this proposed method can be a promising approach to improve the performance of the BCI system and can be an efficient method in daily application.

  17. An improved P300 pattern in BCI to catch user's attention.

    PubMed

    Jin, Jing; Zhang, Hanhan; Daly, Ian; Wang, Xingyu; Cichocki, Andrzej

    2017-06-01

    Brain-computer interfaces (BCIs) can help patients who have lost control over most muscles but are still conscious and able to communicate or interact with the environment. One of the most popular types of BCI is the P300-based BCI. With this BCI, users are asked to count the number of appearances of target stimuli in an experiment. To date, the majority of visual P300-based BCI systems developed have used the same character or picture as the target for every stimulus presentation, which can bore users. Consequently, users attention may decrease or be negatively affected by adjacent stimuli. In this study, a new stimulus is presented to increase user concentration. Honeycomb-shaped figures with 1-3 red dots were used as stimuli. The number and the positions of the red dots in the honeycomb-shaped figure were randomly changed during BCI control. The user was asked to count the number of the dots presented in each flash instead of the number of times they flashed. To assess the performance of this new stimulus, another honeycomb-shaped stimulus, without red dots, was used as a control condition. The results showed that the honeycomb-shaped stimuli with red dots obtained significantly higher classification accuracies and information transfer rates (p  <  0.05) compared to the honeycomb-shaped stimulus without red dots. The results indicate that this proposed method can be a promising approach to improve the performance of the BCI system and can be an efficient method in daily application.

  18. Space-Borne Observations of Intense Gamma-Ray Flashes (TGFs) Above Thunderstorms

    NASA Technical Reports Server (NTRS)

    Fishman, Gerald J.

    2011-01-01

    Intense millisecond flashes of MeV photons have been observed with space-borne detectors. These terrestrial gamma-ray flashes (TGFs) were discovered with the Burst and Transient Source Experiment (BATSE) aboard the Compton Gamma- Ray Observatory (CGRO) in the early 1990s. They are now being observed with several other instruments, including the Gamma-ray Burst Monitor (GBM) detectors on the Fermi Gamma-ray Space Telescope. Although Fermi-GBM was designed and optimized for the observation of cosmic gamma-ray bursts (GRBs), it has unprecedented capabilities for these TGF observations. On several occasions, intense beams of high-energy electrons and positrons have been observed at the geomagnetic conjugate points of TGFs.

  19. EFFECTS OF LASER RADIATION ON MATTER: Simulation of photon acceleration upon irradiation of a mylar target by femtosecond laser pulses

    NASA Astrophysics Data System (ADS)

    Andreev, Stepan N.; Rukhadze, Anri A.; Tarakanov, V. P.; Yakutov, B. P.

    2010-01-01

    Acceleration of protons is simulated by the particle-in-cell (PIC) method upon irradiation of mylar targets of different thicknesses by femtosecond plane-polarised pulsed laser radiation and at different angles of radiation incidence on the target. The comparison of the results of calculations with the experimental data obtained in recent experiments shows their good agreement. The optimal angle of incidence (458) at which the proton energy achieves its absolute maximum is obtained.

  20. Synchronized flash photolysis and pulse deposition in matrix isolation experiments

    NASA Technical Reports Server (NTRS)

    Allamandola, Louis J.; Lucas, Donald; Pimentel, George C.

    1978-01-01

    An apparatus is described which permits flash photolysis of a pulse-deposited gas mixture in a matrix isolation experiment. This technique obviates the limitations of in situ photolysis imposed by the cage effect and by secondary photolysis. The matrix is deposited in pulses at 30-s intervals and photolyzed sequentially by four synchronized flashlamps approximately 1 ms before the pulse strikes the cold surface. Pulsed deposition maintains adequate isolation and causes line narrowing, which enhances spectral sensitivity. The efficacy of flash photolysis combined with pulsed deposition for producing and trapping transient species was demonstrated by infrated detection of CF3 (from photolysis of CF3I/Ar mixtures) and of ClCO (from photolysis of Cl2/CO/Ar mixtures). The apparatus was used to study the photolytic decomposition of gaseous tricarbonylironcyclobutadiene, C4H4Fe(CO)3. The results indicate that the primary photolytic step is not elimination of C4H4, as suggested earlier, but rather of CO.

  1. Pathological proof of cellular death in radiofrequency ablation therapy and correlation with flash echo imaging--an experiment study.

    PubMed

    Fujiki, Kei

    2004-01-01

    The aims of this study were to clarify the geographic distribution of complete cell death in the radiofrequency ablated area in a porcine liver experiment, and to evaluate the efficacy of ultrasonography using contrast media in detecting the area of Radiofrequency-induced cell death. Radiofrequency ablation was performed at 3 sites in each liver in seven swine with a RF2000TM radiofrequency generator using an expandable type needle electrode. The ablation area was investigated histologically by Hematoxylin-Eosin staining and NADH staining. The area of radiofrequency-induced cell death was correlated to the ultrasonographic findings using contrast media, by means of contrast harmonic imaging, flash echo imaging-subtraction and flash echo imaging-power Doppler. The ablation area showed three distinct regions. Although the HE staining did not indicate necrosis, the NADH staining showed a complete loss of cellular activity in the inner and middle layers of the ablation area. However, in the outer layer cells displaying cellular integrity were intermingled with the necrotic cells, indicating that some of the cells in this layer had a chance to survive. Further, in some cases the outer layer of the ablated area had irregular margins. The flash-echo power-doppler images were accurately correlated in size and shape to the pathologically proved region of complete cell death in the radiofrequency-induced lesions. In the marginal part of the radiofrequency ablation area, cell death was incomplete. Flash echo imaging-power doppler was a useful and sensitive real time imaging technique for accurate evaluation of the region of complete cell death.

  2. The Use of MCNP in Flash Radiographic Applications at AWE

    NASA Astrophysics Data System (ADS)

    Quillin, S.; Crotch, I.; McAlpin, S.; O'Malley, J.

    AWE performs experiments to investigate the hydrodynamic behavior of explosive metal systems in order to underwrite the UK nuclear deterrent. The experiments involve the manufacture of a device to mock up some aspect of the weapon. Inert simulant materials replace fissile weapon components. The device is then detonated under remote control within specially designed explosive containment buildings called firing chambers. During the experiment a very brief, intense, collimated flash of high energy x-rays are used to take a snapshot of the implosion (see Fig. 1). Prom the resulting image measurements of the dynamic configuration and density distribution of the components in the device are inferred. These are then used to compare with calculations of the hydrodynamic operation of the weapon and understand how the device would perform under various conditions. This type of experiment is known as a core punch experiment.

  3. The kinematic and microphysical control of lightning rate, extent, and NOX production

    NASA Astrophysics Data System (ADS)

    Carey, Lawrence D.; Koshak, William; Peterson, Harold; Mecikalski, Retha M.

    2016-07-01

    This study investigates the kinematic and microphysical control of lightning properties, particularly those that may govern the production of nitrogen oxides (NOX = NO + NO2) via lightning (LNOX), such as flash rate, type, and extent. The NASA Lightning Nitrogen Oxides Model (LNOM) is applied to lightning observations following multicell thunderstorms through their lifecycle in a Lagrangian sense over Northern Alabama on 21 May 2012 during the Deep Convective Clouds and Chemistry (DC3) experiment. LNOM provides estimates of flash rate, type, channel length distributions, channel segment altitude distributions (SADs), and LNOX production profiles. The LNOM-derived lightning characteristics and LNOX production are compared to the evolution of radar-inferred updraft and precipitation properties. Intercloud, intracloud (IC) flash SAD comprises a significant fraction of the total (IC + cloud-to-ground [CG]) SAD, while increased CG flash SAD at altitudes >6 km occurs after the simultaneous peaks in several thunderstorm properties (i.e., total [IC + CG] and IC flash rate, graupel volume/mass, convective updraft volume, and maximum updraft speed). At heights <6 km, the CG LNOX production dominates the column-integrated total LNOX production. Unlike the SAD, total LNOX production consists of a more equal contribution from IC and CG flashes for heights >6 km. Graupel volume/mass, updraft volume, and maximum updraft speed are all well correlated to the total flash rate (correlation coefficient, ρ ≥ 0.8) but are less correlated to total flash extent (ρ ≥ 0.6) and total LNOX production (ρ ≥ 0.5). Although LNOM transforms lightning observations into LNOX production values, these values are estimates and are subject to further independent validation.

  4. A global flash flood forecasting system

    NASA Astrophysics Data System (ADS)

    Baugh, Calum; Pappenberger, Florian; Wetterhall, Fredrik; Hewson, Tim; Zsoter, Ervin

    2016-04-01

    The sudden and devastating nature of flash flood events means it is imperative to provide early warnings such as those derived from Numerical Weather Prediction (NWP) forecasts. Currently such systems exist on basin, national and continental scales in Europe, North America and Australia but rely on high resolution NWP forecasts or rainfall-radar nowcasting, neither of which have global coverage. To produce global flash flood forecasts this work investigates the possibility of using forecasts from a global NWP system. In particular we: (i) discuss how global NWP can be used for flash flood forecasting and discuss strengths and weaknesses; (ii) demonstrate how a robust evaluation can be performed given the rarity of the event; (iii) highlight the challenges and opportunities in communicating flash flood uncertainty to decision makers; and (iv) explore future developments which would significantly improve global flash flood forecasting. The proposed forecast system uses ensemble surface runoff forecasts from the ECMWF H-TESSEL land surface scheme. A flash flood index is generated using the ERIC (Enhanced Runoff Index based on Climatology) methodology [Raynaud et al., 2014]. This global methodology is applied to a series of flash floods across southern Europe. Results from the system are compared against warnings produced using the higher resolution COSMO-LEPS limited area model. The global system is evaluated by comparing forecasted warning locations against a flash flood database of media reports created in partnership with floodlist.com. To deal with the lack of objectivity in media reports we carefully assess the suitability of different skill scores and apply spatial uncertainty thresholds to the observations. To communicate the uncertainties of the flash flood system output we experiment with a dynamic region-growing algorithm. This automatically clusters regions of similar return period exceedence probabilities, thus presenting the at-risk areas at a spatial resolution appropriate to the NWP system. We then demonstrate how these warning areas could eventually complement existing global systems such as the Global Flood Awareness System (GloFAS), to give warnings of flash floods. This work demonstrates the possibility of creating a global flash flood forecasting system based on forecasts from existing global NWP systems. Future developments, in post-processing for example, will need to address an under-prediction bias, for extreme point rainfall, that is innate to current-generation global models.

  5. Composite uranium carbide targets at TRIUMF: Development and characterization with SEM, XRD, XRF and L-edge densitometry

    NASA Astrophysics Data System (ADS)

    Kunz, Peter; Bricault, Pierre; Dombsky, Marik; Erdmann, Nicole; Hanemaayer, Vicky; Wong, John; Lützenkirchen, Klaus

    2013-09-01

    The production of radioactive ion beams (RIB) from spallation targets by irradiation with a continuous 500 MeV proton beam, has been routine at TRIUMF for several years. Based on the experience with composite refractory carbide targets a procedure for the fabrication of UC2/C targets was developed. It includes the preparation of UC2 by carbothermal reduction of UO2, the slip-casting of fine-grained UC2/C slurry on graphite foil under inert gas atmosphere and the cutting of composite target discs which are stacked up to a lamellar structure. The thermal properties of such an arrangement are adequate to withstand the high power deposition of an intense, continuous proton beam and also beneficial for the fast release of short-lived radioactive isotopes. Molecular structure, particle size and the impact of sintering of the target discs were investigated via XRD and SEM. Thickness and mass distribution were measured with position-sensitive LIII-edge densitometry. The results confirm that the properties of the UC2/C target material are well suited for RIB production at TRIUMF while there is still room for improvement with regard to uniformity of mass distribution in target disc thickness.

  6. Neural basis of superior performance of action videogame players in an attention-demanding task.

    PubMed

    Mishra, Jyoti; Zinni, Marla; Bavelier, Daphne; Hillyard, Steven A

    2011-01-19

    Steady-state visual evoked potentials (SSVEPs) were recorded from action videogame players (VGPs) and from non-videogame players (NVGPs) during an attention-demanding task. Participants were presented with a multi-stimulus display consisting of rapid sequences of alphanumeric stimuli presented at rates of 8.6/12 Hz in the left/right peripheral visual fields, along with a central square at fixation flashing at 5.5 Hz and a letter sequence flashing at 15 Hz at an upper central location. Subjects were cued to attend to one of the peripheral or central stimulus sequences and detect occasional targets. Consistent with previous behavioral studies, VGPs detected targets with greater speed and accuracy than NVGPs. This behavioral advantage was associated with an increased suppression of SSVEP amplitudes to unattended peripheral sequences in VGPs relative to NVGPs, whereas the magnitude of the attended SSVEPs was equivalent in the two groups. Group differences were also observed in the event-related potentials to targets in the alphanumeric sequences, with the target-elicited P300 component being of larger amplitude in VGPS than NVGPs. These electrophysiological findings suggest that the superior target detection capabilities of the VGPs are attributable, at least in part, to enhanced suppression of distracting irrelevant information and more effective perceptual decision processes.

  7. Object width modulates object-based attentional selection.

    PubMed

    Nah, Joseph C; Neppi-Modona, Marco; Strother, Lars; Behrmann, Marlene; Shomstein, Sarah

    2018-04-24

    Visual input typically includes a myriad of objects, some of which are selected for further processing. While these objects vary in shape and size, most evidence supporting object-based guidance of attention is drawn from paradigms employing two identical objects. Importantly, object size is a readily perceived stimulus dimension, and whether it modulates the distribution of attention remains an open question. Across four experiments, the size of the objects in the display was manipulated in a modified version of the two-rectangle paradigm. In Experiment 1, two identical parallel rectangles of two sizes (thin or thick) were presented. Experiments 2-4 employed identical trapezoids (each having a thin and thick end), inverted in orientation. In the experiments, one end of an object was cued and participants performed either a T/L discrimination or a simple target-detection task. Combined results show that, in addition to the standard object-based attentional advantage, there was a further attentional benefit for processing information contained in the thick versus thin end of objects. Additionally, eye-tracking measures demonstrated increased saccade precision towards thick object ends, suggesting that Fitts's Law may play a role in object-based attentional shifts. Taken together, these results suggest that object-based attentional selection is modulated by object width.

  8. Phase Contrast Imaging of Damage Initiation During Ballistic Impact of Boron Carbide

    NASA Astrophysics Data System (ADS)

    Schuster, Brian; Tonge, Andrew; Ramos, Kyle; Rigg, Paulo; Iverson, Adam; Schuman, Adam; Lorenzo, Nicholas

    2017-06-01

    For several decades, flash X-ray imaging has been used to perform time-resolved investigations of the response of ceramics under ballistic impact. Traditional absorption based contrast offers little insight into the early initiation of inelastic deformation mechanisms and instead typically only shows the gross deformation and fracture behavior. In the present work, we employed phase contrast imaging (PCI) at the Dynamic Compression Sector (DCS) at the Advanced Photon Source, Argonne National Laboratory, to investigate crack initiation and propagation following the impact of copper penetrators into boron carbide targets. These experiments employed a single-stage propellant gun to launch small-scale (0.6 mm diameter by 3 mm long) pure copper impactors at velocities ranging from 0.9 to 1.9 km/s into commercially available boron carbide targets that were 8 mm on a side. At the lowest striking velocities the penetrator undergoes dwell or interface defeat and the target response is consistent with the cone crack formation at the impact site. At higher striking velocities there is a distinct transition to massive fragmentation leading to the onset of penetration.

  9. Mitochondrial flashes: From indicator characterization to in vivo imaging.

    PubMed

    Wang, Wang; Zhang, Huiliang; Cheng, Heping

    2016-10-15

    Mitochondrion is an organelle critically responsible for energy production and intracellular signaling in eukaryotic cells and its dysfunction often accompanies and contributes to human disease. Superoxide is the primary reactive oxygen species (ROS) produced in mitochondria. In vivo detection of superoxide has been a challenge in biomedical research. Here we describe the methods used to characterize a circularly permuted yellow fluorescent protein (cpYFP) as a biosensor for mitochondrial superoxide and pH dynamics. In vitro characterization reveals the high selectivity of cpYFP to superoxide over other ROS species and its dual sensitivity to pH. Confocal and two-photon imaging in conjunction with transgenic expression of the biosensor cpYFP targeted to the mitochondrial matrix detects mitochondrial flash events in living cells, perfused intact hearts, and live animals. The mitochondrial flashes are discrete and stochastic single mitochondrial events triggered by transient mitochondrial permeability transition (tMPT) and composed of a bursting superoxide signal and a transient alkalization signal. The real-time monitoring of single mitochondrial flashes provides a unique tool to study the integrated dynamism of mitochondrial respiration, ROS production, pH regulation and tMPT kinetics under diverse physiological and pathophysiological conditions. Copyright © 2016 Elsevier Inc. All rights reserved.

  10. Impact cratering experiments in brittle targets with variable thickness: Implications for deep pit craters on Mars

    NASA Astrophysics Data System (ADS)

    Michikami, T.; Hagermann, A.; Miyamoto, H.; Miura, S.; Haruyama, J.; Lykawka, P. S.

    2014-06-01

    High-resolution images reveal that numerous pit craters exist on the surface of Mars. For some pit craters, the depth-to-diameter ratios are much greater than for ordinary craters. Such deep pit craters are generally considered to be the results of material drainage into a subsurface void space, which might be formed by a lava tube, dike injection, extensional fracturing, and dilational normal faulting. Morphological studies indicate that the formation of a pit crater might be triggered by the impact event, and followed by collapse of the ceiling. To test this hypothesis, we carried out laboratory experiments of impact cratering into brittle targets with variable roof thickness. In particular, the effect of the target thickness on the crater formation is studied to understand the penetration process by an impact. For this purpose, we produced mortar targets with roof thickness of 1-6 cm, and a bulk density of 1550 kg/m3 by using a mixture of cement, water and sand (0.2 mm) in the ratio of 1:1:10, by weight. The compressive strength of the resulting targets is 3.2±0.9 MPa. A spherical nylon projectile (diameter 7 mm) is shot perpendicularly into the target surface at the nominal velocity of 1.2 km/s, using a two-stage light-gas gun. Craters are formed on the opposite side of the impact even when no target penetration occurs. Penetration of the target is achieved when craters on the opposite sides of the target connect with each other. In this case, the cross section of crater somehow attains a flat hourglass-like shape. We also find that the crater diameter on the opposite side is larger than that on the impact side, and more fragments are ejected from the crater on the opposite side than from the crater on the impact side. This result gives a qualitative explanation for the observation that the Martian deep pit craters lack a raised rim and have the ejecta deposit on their floor instead. Craters are formed on the opposite impact side even when no penetration occurs. Penetration is achieved when craters of both sides are connected. Crater diameter on the opposite side is larger than that on the impact side. More fragments are ejected from the opposite side than from the impact side. We present a qualitative explanation for the shapes of Martian deep pit craters.

  11. Single-particle coherent diffractive imaging with a soft x-ray free electron laser: towards soot aerosol morphology

    NASA Astrophysics Data System (ADS)

    Bogan, Michael J.; Starodub, Dmitri; Hampton, Christina Y.; Sierra, Raymond G.

    2010-10-01

    The first of its kind, the Free electron LASer facility in Hamburg, FLASH, produces soft x-ray pulses with unprecedented properties (10 fs, 6.8-47 nm, 1012 photons per pulse, 20 µm diameter). One of the seminal FLASH experiments is single-pulse coherent x-ray diffractive imaging (CXDI). CXDI utilizes the ultrafast and ultrabright pulses to overcome resolution limitations in x-ray microscopy imposed by x-ray-induced damage to the sample by 'diffracting before destroying' the sample on sub-picosecond timescales. For many lensless imaging algorithms used for CXDI it is convenient when the data satisfy an oversampling constraint that requires the sample to be an isolated object, i.e. an individual 'free-standing' portion of disordered matter delivered to the centre of the x-ray focus. By definition, this type of matter is an aerosol. This paper will describe the role of aerosol science methodologies used for the validation of the 'diffract before destroy' hypothesis and the execution of the first single-particle CXDI experiments being developed for biological imaging. FLASH CXDI now enables the highest resolution imaging of single micron-sized or smaller airborne particulate matter to date while preserving the native substrate-free state of the aerosol. Electron microscopy offers higher resolution for single-particle analysis but the aerosol must be captured on a substrate, potentially modifying the particle morphology. Thus, FLASH is poised to contribute significant advancements in our knowledge of aerosol morphology and dynamics. As an example, we simulate CXDI of combustion particle (soot) morphology and introduce the concept of extracting radius of gyration of fractal aggregates from single-pulse x-ray diffraction data. Future upgrades to FLASH will enable higher spatially and temporally resolved single-particle aerosol dynamics studies, filling a critical technological need in aerosol science and nanotechnology. Many of the methodologies described for FLASH will directly translate to use at hard x-ray free electron lasers.

  12. Richtmyer-Meshkov jet formation from rear target ripples in plastic and plastic/aluminum laser targets

    NASA Astrophysics Data System (ADS)

    Aglitskiy, Y.; Velikovich, A. L.; Karasik, M.; Serlin, V.; Weaver, J. L.; Schmitt, A. J.; Obenschain, S. P.

    2015-11-01

    We report experimental observations of jets produced from the rear surface of laser targets after a passage of the laser-driven shock wave. As in our previous work, Aglitskiy et al., Phys. Plasmas (2012), the jets are produced via the shaped-charge mechanism, a manifestation of a Richtmyer-Meshkov instability for a particular case of the Atwood number A =-1. The experiments done on the KrF Nike laser facility with laser wavelength 248 nm, a 4 ns pulse, and low-energy drive regime that used only 1 to 3 overlapping Nike beams and generated ablative pressure below 1 Mbar. Our 50 um thick planar targets were rippled on the rear side with wavelength 45 μm and peak-to-valley amplitude 15 μm. The targets were made either of solid plastic or of aluminum with a 10 μm thick plastic ablator attached to avoid the radiation preheat. The jets were extremely well collimated, which made possible our side-on observations with monochromatic x-ray imaging. We saw a regular set of jets, clearly separated along the 500 μm line of sight. Aluminum jets were found to be slightly better collimated than plastic jets. A quasi-spherical late-time expansion of Al jets starting from the tips has not been previously seen in experiments or simulations. Work supported by the US DOE/NNSA.

  13. D-T Neutron Skyshine Experiments at JAERI/FNS

    NASA Astrophysics Data System (ADS)

    Nishitani, Takeo; Ochiai, Kentaro; Yoshida, Shigeo; Tanaka, Ryohei; Wakisaka, Masashi; Nakao, Makoto; Sato, Satoshi; Yamauchi, Michinori; Hori, Jun-Ichi; Takahashi, Akito; Kaneko, Jun-Ichi; Sawamura, Teruko

    The D-T neutron skyshine experiments have been carried out at the Fusion Neutronics Source (FNS) of JAERI with the neutron yield of ˜1.7×1011n/s. The concrete thickness of the roof and the wall of a FNS target room are 1.15 and 2 m, respectively. The FNS skyshine port with a size of 0.9 × 0.9 m2 was open during the experimental period.The radiation dose rate outside the target room was measured as far as about 550 m away from the D-T target point with a spherical rem-counter. The highest neutron dose was about 0.5 μSv/hr at a distance of 30 m from the D-T target point and the dose rate was attenuated to 0.002 μSv/hr at a distance of 550 m. The measured neutron dose distribution was analyzed with Monte Carlo code MCNP-4B and a simple line source model. The MCNP calculation overestimates the neutron dose in the distance range larger than 250 m. The neutron spectra were evaluated with a 3He detector with different thickness of polyethylene neutron moderators. Secondary gamma-rays were measured with high purity Ge detectors and NaI scintillation detectors.

  14. Simulation Experiments of Reacting Two-Phase Flow

    DTIC Science & Technology

    1987-04-06

    to 50 % of the lower gas explosion limit (4 % ofhydrogen in the surrounding air ). Then, this device automatically stops the filling procedure...and the discharge of the rifle into air 68 36. Final chamber pressure versus time (Charge pr’,ssure P, = 12 MPa; closed bomb mode) 70 37. Final...surrounding air , which is entrained turbulently, a combustion process can take place that results in a high intensity flash, called muzzle flash [6

  15. Physics Flash December 2016

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kippen, Karen Elizabeth

    This is the December 2016 issue of Physics Flash, the newsletter of the Physics Division of Los Alamos National Laboratory (LANL). In this issue, the following topics are covered: Novel liquid helium technique to aid highly sensitive search for a neutron electrical dipole moment; Silverleaf: Prototype Red Sage experiments performed at Q-site; John L. Kline named 2016 APS Fellow; Physics students in the news; First Entropy Engine quantum random number generator hits the market; and celebrating service.

  16. Therapeutic options for the management of hot flashes in breast cancer survivors: an evidence-based review.

    PubMed

    Bordeleau, Louise; Pritchard, Kathleen; Goodwin, Pamela; Loprinzi, Charles

    2007-02-01

    Women with breast cancer may experience treatment-induced menopausal symptoms or natural menopause. Menopausal symptoms, particularly hot flashes, are reported at a high frequency in this group and tend to be more severe, distressing, and of greater duration than in controls. Because of the contribution of sex hormones to breast cancer, the use of hormonal agents for the control of hot flashes is problematic in these women. Safer nonhormonal alternatives are recommended for this patient group. This was a systematic review of the therapeutic options for the treatment of hot flashes in breast cancer survivors. MEDLINE was searched from 1990 to July 2006 using the disease-specific term breast neoplasms and the subheadings menopause and hot flashes. EMBASE was searched from 1990 to March 2006 using the disease-specific subject headings breast tumor/ breast cancer and menopause and the key word hot flashes. The reference lists of the identified articles and relevant review articles were examined for additional publications. Pertinent articles and abstracts of large randomized controlled trials focusing on the treatment of hot flashes in breast cancer survivors were selected for review. Pilot studies were excluded. A number of nonpharmacologic approaches are available for the treatment of hot flashes in breast cancer survivors, although they appear to be of limited effectiveness. Complementary alternative medicine therapies and vitamin E have been found to have modest effectiveness at best, and data on their long-term safety are not available. Centrally active agents such as the antidepressants venlafaxine and paroxetine and the anti seizure agent gabapentin have shown clinical effectiveness and appear to be reasonably well tolerated in this population. Centrally active agents (eg, venlafaxine, paroxetine, gabapentin) are regarded as the most promising nonhormonal treatments for hot flashes in breast cancer survivors. Nonpharmacologic and complementary alternative medicine therapies have limited effectiveness.

  17. Gabapentin for hot flashes in 420 women with breast cancer: a randomised double-blind placebo-controlled trial

    PubMed Central

    Pandya, K J; Morrow, G R; Roscoe, J A; Hickok, J T; Zhao, H; Pajon, E; Sweeney, T J; Banerjee, T K; Flynn, P J

    2005-01-01

    Summary Background Most women receiving systemic therapy for breast cancer experience hot flashes. We undertook a randomised, double-blind, placebo-controlled, multi-institutional trial to assess the efficacy of gabapentin in controlling hot flashes in women with breast cancer. Methods 420 women with breast cancer who were having two or more hot flashes per day were randomly assigned placebo, gabapentin 300 mg/day, or gabapentin 900 mg/day by mouth in three divided doses for 8 weeks. Each patient kept a 1-week, self-report diary on the frequency, severity, and duration of hot flashes before the start of the study and during weeks 4 and 8 of treatment. Analyses were by intention to treat. Findings Evaluable data were available on 371 participants at 4 weeks (119 placebo, 123 gabapentin 300 mg, and 129 gabapentin 900 mg) and 347 at 8 weeks (113 placebo, 114 gabapentin 300 mg, and 120 gabapentin 900 mg). The percentage decreases in hot-flash severity score between baseline and weeks 4 and 8, respectively were: 21% (95% CI 12 to 30) and 15% (1 to 29) in the placebo group; 33% (23 to 43) and 31% (16 to 46) in the group assigned gabapentin 300 mg; and 49% (42 to 56) and 46% (34 to 58) in the group assigned gabapentin 900 mg. The differences between the groups were significant (p=0.0001 at 4 weeks and p=0.007 at 8 weeks by ANCOVA for overall treatment effect, adjusted for baseline values); only the higher dose of gabapentin was associated with significant decreases in hot-flash frequency and severity. Interpretation Gabapentin is effective in the control of hot flashes at a dose of 900 mg/day, but not at a dose of 300 mg/day. This drug should be considered for treatment of hot flashes in women with breast cancer. PMID:16139656

  18. Suppressing flashes of items surrounding targets during calibration of a P300-based brain-computer interface improves performance

    NASA Astrophysics Data System (ADS)

    Frye, G. E.; Hauser, C. K.; Townsend, G.; Sellers, E. W.

    2011-04-01

    Since the introduction of the P300 brain-computer interface (BCI) speller by Farwell and Donchin in 1988, the speed and accuracy of the system has been significantly improved. Larger electrode montages and various signal processing techniques are responsible for most of the improvement in performance. New presentation paradigms have also led to improvements in bit rate and accuracy (e.g. Townsend et al (2010 Clin. Neurophysiol. 121 1109-20)). In particular, the checkerboard paradigm for online P300 BCI-based spelling performs well, has started to document what makes for a successful paradigm, and is a good platform for further experimentation. The current paper further examines the checkerboard paradigm by suppressing items which surround the target from flashing during calibration (i.e. the suppression condition). In the online feedback mode the standard checkerboard paradigm is used with a stepwise linear discriminant classifier derived from the suppression condition and one classifier derived from the standard checkerboard condition, counter-balanced. The results of this research demonstrate that using suppression during calibration produces significantly more character selections/min ((6.46) time between selections included) than the standard checkerboard condition (5.55), and significantly fewer target flashes are needed per selection in the SUP condition (5.28) as compared to the RCP condition (6.17). Moreover, accuracy in the SUP and RCP conditions remained equivalent (~90%). Mean theoretical bit rate was 53.62 bits/min in the suppression condition and 46.36 bits/min in the standard checkerboard condition (ns). Waveform morphology also showed significant differences in amplitude and latency.

  19. Observation and modeling of deflagration-to-detonation transition (DDT) in low-density HMX

    NASA Astrophysics Data System (ADS)

    Tringe, Joseph W.; Vandersall, Kevin S.; Reaugh, John E.; Levie, Harold W.; Henson, Bryan F.; Smilowitz, Laura B.; Parker, Gary R.

    2017-01-01

    We employ simultaneous flash x-ray radiography and streak imaging, together with a multi-phase finite element model, to understand deflagration-to-detonation transition (DDT) phenomena in low-density (˜1.2 gm/cm3) powder of the explosive cyclotetramethylene-tetranitramine (HMX). HMX powder was lightly hand-tamped in a 12.7 mm diameter column, relatively lightly-confined in an optically-transparent polycarbonate cylinder with wall thickness 25.4 mm. We observe apparent compaction of the powder in advance of the detonation transition by the motion of small steel spheres pre-emplaced throughout the length of explosive. High-speed imaging along the explosive cylinder length provides a more temporally continuous record of the transition that is correlated with the high-resolution x-ray image record. Preliminary simulation of these experiments with the HERMES model implemented in the ALE3D code enables improved understanding of the explosive particle burning, compaction and detonation phenomena which are implied by the observed reaction rate and transition location within the cylinder.

  20. Neural Responses in Parietal and Occipital Areas in Response to Visual Events Are Modulated by Prior Multisensory Stimuli

    PubMed Central

    Innes-Brown, Hamish; Barutchu, Ayla; Crewther, David P.

    2013-01-01

    The effect of multi-modal vs uni-modal prior stimuli on the subsequent processing of a simple flash stimulus was studied in the context of the audio-visual ‘flash-beep’ illusion, in which the number of flashes a person sees is influenced by accompanying beep stimuli. EEG recordings were made while combinations of simple visual and audio-visual stimuli were presented. The experiments found that the electric field strength related to a flash stimulus was stronger when it was preceded by a multi-modal flash/beep stimulus, compared to when it was preceded by another uni-modal flash stimulus. This difference was found to be significant in two distinct timeframes – an early timeframe, from 130–160 ms, and a late timeframe, from 300–320 ms. Source localisation analysis found that the increased activity in the early interval was localised to an area centred on the inferior and superior parietal lobes, whereas the later increase was associated with stronger activity in an area centred on primary and secondary visual cortex, in the occipital lobe. The results suggest that processing of a visual stimulus can be affected by the presence of an immediately prior multisensory event. Relatively long-lasting interactions generated by the initial auditory and visual stimuli altered the processing of a subsequent visual stimulus. PMID:24391939

  1. A Unified Flash Flood Database across the United States

    USGS Publications Warehouse

    Gourley, Jonathan J.; Hong, Yang; Flamig, Zachary L.; Arthur, Ami; Clark, Robert; Calianno, Martin; Ruin, Isabelle; Ortel, Terry W.; Wieczorek, Michael; Kirstetter, Pierre-Emmanuel; Clark, Edward; Krajewski, Witold F.

    2013-01-01

    Despite flash flooding being one of the most deadly and costly weather-related natural hazards worldwide, individual datasets to characterize them in the United States are hampered by limited documentation and can be difficult to access. This study is the first of its kind to assemble, reprocess, describe, and disseminate a georeferenced U.S. database providing a long-term, detailed characterization of flash flooding in terms of spatiotemporal behavior and specificity of impacts. The database is composed of three primary sources: 1) the entire archive of automated discharge observations from the U.S. Geological Survey that has been reprocessed to describe individual flooding events, 2) flash-flooding reports collected by the National Weather Service from 2006 to the present, and 3) witness reports obtained directly from the public in the Severe Hazards Analysis and Verification Experiment during the summers 2008–10. Each observational data source has limitations; a major asset of the unified flash flood database is its collation of relevant information from a variety of sources that is now readily available to the community in common formats. It is anticipated that this database will be used for many diverse purposes, such as evaluating tools to predict flash flooding, characterizing seasonal and regional trends, and improving understanding of dominant flood-producing processes. We envision the initiation of this community database effort will attract and encompass future datasets.

  2. Managing Systematic Errors in a Polarimeter for the Storage Ring EDM Experiment

    NASA Astrophysics Data System (ADS)

    Stephenson, Edward J.; Storage Ring EDM Collaboration

    2011-05-01

    The EDDA plastic scintillator detector system at the Cooler Synchrotron (COSY) has been used to demonstrate that it is possible using a thick target at the edge of the circulating beam to meet the requirements for a polarimeter to be used in the search for an electric dipole moment on the proton or deuteron. Emphasizing elastic and low Q-value reactions leads to large analyzing powers and, along with thick targets, to efficiencies near 1%. Using only information obtained comparing count rates for oppositely vector-polarized beam states and a calibration of the sensitivity of the polarimeter to rate and geometric changes, the contribution of systematic errors can be suppressed below the level of one part per million.

  3. HARP targets pion production cross section and yield measurements: Implications for MiniBooNE neutrino flux

    NASA Astrophysics Data System (ADS)

    Wickremasinghe, Don Athula Abeyarathna

    The prediction of the muon neutrino flux from a 71.0 cm long beryllium target for the MiniBooNE experiment is based on a measured pion production cross section which was taken from a short beryllium target (2.0 cm thick - 5% nuclear interaction length) in the Hadron Production (HARP) experiment at CERN. To verify the extrapolation to our longer target, HARP also measured the pion production from 20.0 cm and 40.0 cm beryllium targets. The measured production yields on targets of 50% and 100% nuclear interaction lengths in the kinematic rage of momentum from 0.75 GeV/c to 6.5 GeV/c and the range of angle from 30 mrad to 210 mrad are presented along with an update of the short target cross sections. The best fitted extended Sanford-Wang (SW) model parameterization for updated short beryllium target positive pion production cross section is presented. Yield measurements for all three targets are also compared with that from the Monte Carlo predictions in the MiniBooNE experiment for different SW parameterization. The comparisons of muon neutrino flux predictions for updated SW model is presented.

  4. Chromatic induction in space and time.

    PubMed

    Coia, Andrew J; Shevell, Steven K

    2018-04-01

    The color appearance of a light depends on variation in the complete visual field over both space and time. In the spatial domain, a chromatic stimulus within a patterned chromatic surround can appear a different hue than the same stimulus within a uniform surround. In the temporal domain, a stimulus presented as an element of a continuously changing chromaticity can appear a different color compared to the identical stimulus, presented simultaneously but viewed alone. This is the flash-lag effect for color, which has an analog in the domain of motion: a pulsed object seen alone can appear to lag behind an identical pulsed object that is an element of a motion sequence. Studies of the flash-lag effect for motion have considered whether it is mediated by a neural representation for the moving physical stimulus or, alternatively, for the perceived motion. The current study addresses this question for the flash-lag effect for color by testing whether the color flash lag depends on a representation of only the changing chromatic stimulus or, alternatively, its color percept, which can be altered by chromatic induction. baseline measurements for spatial chromatic induction determined the chromaticity of a flashed ring within a uniform surround that matched a flashed ring within a patterned surround. Baseline measurements for the color flash-lag effect determined the chromaticity of a pulsed ring presented alone (within a uniform surround) that matched a pulsed ring presented in a sequence of changing chromaticity over time (also within a uniform surround). Finally, the main experiments combined chromatic induction from a patterned surround and the flash-lag effect, in three conditions: (1) both the changing and pulsed rings were within a patterned chromatic surround; (2) the changing ring was within a patterned surround and the pulsed ring within a uniform surround; and (3) the changing ring was within a uniform surround and the pulsed ring within a patterned surround. the flash-lag measurements for a changing chromaticity were affected by perceptual changes induced by the surrounding chromatic pattern. Thus, the color shifts induced by a chromatic surround are incorporated in the neural representation mediating the flash-lag effect for color.

  5. Spatial Probability Dynamically Modulates Visual Target Detection in Chickens

    PubMed Central

    Sridharan, Devarajan; Ramamurthy, Deepa L.; Knudsen, Eric I.

    2013-01-01

    The natural world contains a rich and ever-changing landscape of sensory information. To survive, an organism must be able to flexibly and rapidly locate the most relevant sources of information at any time. Humans and non-human primates exploit regularities in the spatial distribution of relevant stimuli (targets) to improve detection at locations of high target probability. Is the ability to flexibly modify behavior based on visual experience unique to primates? Chickens (Gallus domesticus) were trained on a multiple alternative Go/NoGo task to detect a small, briefly-flashed dot (target) in each of the quadrants of the visual field. When targets were presented with equal probability (25%) in each quadrant, chickens exhibited a distinct advantage for detecting targets at lower, relative to upper, hemifield locations. Increasing the probability of presentation in the upper hemifield locations (to 80%) dramatically improved detection performance at these locations to be on par with lower hemifield performance. Finally, detection performance in the upper hemifield changed on a rapid timescale, improving with successive target detections, and declining with successive detections at the diagonally opposite location in the lower hemifield. These data indicate the action of a process that in chickens, as in primates, flexibly and dynamically modulates detection performance based on the spatial probabilities of sensory stimuli as well as on recent performance history. PMID:23734188

  6. Studying the hydro-meteorological extremes. The benefits from the European Flash Flood research oriented HYDRATE project.

    NASA Astrophysics Data System (ADS)

    Tsanis, Ioannis K.; Koutroulis, Aristeidis G.; Daliakopoulos, Ioannis N.; Grillakis, Emmanouil G.

    2010-05-01

    The present paper summarizes the advances of flash flood research for the Greek case study, within the frame of HYDRATE EC funded project. As a first step, a collation of homogenous primary data on flash floods occurred in Greece based on various data sources resulted in 21 documented events, enriching the HYDRATE database. Specific major events were selected for further detailed data collation and analysis. A common intensive post event field survey was conducted by various researchers with different skills and experience, in order to document the 18th of September 2007, Western Slovenia flash flood event. The observation strategy and the lessons learned during this campaign were applied successfully for surveying an event in Crete. Two flash flood events occurred in Crete were selected for detailed analysis, the 13th of January 1994 event occurred in Giofiros basin and the 17th of October 2006 event occurred in Almirida basin. Several techniques, like distributed rainfall-runoff modelling, hydraulic modelling, indirect and empirical peak discharge estimation, were applied for the understanding of the dominant flash flood processes and the effect of initial conditions on peak discharge. In a more general framework, the seasonality of the hydrometeorologic characteristics of floods that occurred in Crete during the period 1990-2007 and the atmospheric circulation conditions during the flood events were examined. During the three and a half years research period, many lessons have learnt from a fruitful collaboration among the project partners. HYDRATE project improved the scientific basis of flash flood research and provided research knowledge on flood risk management.

  7. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Savelyev, Evgeny; Boll, Rebecca; Bomme, Cedric

    In pump-probe experiments employing a free-electron laser (FEL) in combination with a synchronized optical femtosecond laser, the arrival-time jitter between the FEL pulse and the optical laser pulse often severely limits the temporal resolution that can be achieved. Here, we present a pump-probe experiment on the UV-induced dissociation of 2,6-difluoroiodobenzene C 6H 3F 2I) molecules performed at the FLASH FEL that takes advantage of recent upgrades of the FLASH timing and synchronization system to obtain high-quality data that are not limited by the FEL arrival-time jitter. Here, we discuss in detail the necessary data analysis steps and describe the originmore » of the time-dependent effects in the yields and kinetic energies of the fragment ions that we observe in the experiment.« less

  8. Mobile computing device as tools for college student education: a case on flashcards application

    NASA Astrophysics Data System (ADS)

    Kang, Congying

    2012-04-01

    Traditionally, college students always use flash cards as a tool to remember massive knowledge, such as nomenclature, structures, and reactions in chemistry. Educational and information technology have enabled flashcards viewed on computers, like Slides and PowerPoint, works as tunnels of drilling and feedback for the learners. The current generation of students is more capable of information technology and mobile computing devices. For example, they use their Mobile phones much more intensively everyday day. Trends of using Mobile phone as an educational tool is analyzed and a educational technology initiative is proposed, which use Mobile phone flash cards applications to help students learn biology and chemistry. Experiments show that users responded positively to these mobile flash cards.

  9. Experimental impacts into Teflon targets and LDEF thermal blankets

    NASA Astrophysics Data System (ADS)

    Hoerz, F.; Cintala, M. J.; Zolensky, M. E.; Bernhard, R. P.; See, T. H.

    1994-03-01

    The Long Duration Exposure Facility (LDEF) exposed approximately 20 sq m of identical thermal protective blankets, predominantly on the Ultra-Heavy Cosmic Ray Experiment (UHCRE). Approximately 700 penetration holes greater than 300 micron in diameter were individually documented, while thousands of smaller penetrations and craters occurred in these blankets. As a result of their 5.7 year exposure and because they pointed into a variety of different directions relative to the orbital motion of the nonspinning LDEF platform, these blankets can reveal important dynamic aspects of the hypervelocity particle environment in near-earth orbit. The blankets were composed of an outer teflon layer (approximately 125 micron thick), followed by a vapor-deposited rear mirror of silver (less than 1000 A thick) that was backed with an organic binder and a thermal protective paint (approximately 50 to 75 micron thick), resulting in a cumulative thickness (T) of approximately 175 to 200 microns for the entire blanket. Many penetrations resulted in highly variable delaminations of the teflon/metal or metal/organic binder interfaces that manifest themselves as 'dark' halos or rings, because of subsequent oxidation of the exposed silver mirror. The variety of these dark albedo features is bewildering, ranging from totally absent, to broad halos, to sharp single or multiple rings. Over the past year experiments were conducted over a wide range of velocities (i.e., 1 to 7 km/s) to address velocity dependent aspects of cratering and penetrations of teflon targets. In addition, experiments were performed with real LDEF thermal blankets to duplicate the LDEF delaminations and to investigate a possible relationship of initial impact conditions on the wide variety of dark halo and ring features.

  10. Defining the unknowns of sonoluminescence

    NASA Astrophysics Data System (ADS)

    Barber, Bradley P.; Hiller, Robert A.; Löfstedt, Ritva; Putterman, Seth J.; Weninger, Keith R.

    1997-03-01

    As the intensity of a standing sound wave is increased the pulsations of a bubble of gas trapped at a velocity node attain sufficient amplitude so as to emit picosecond flashes of light with a broadband spectrum that increases into the ultraviolet. The acoustic resonator can be tuned so that the flashes of light occur with a clocklike regularity: one flash for each cycle of sound with a jitter in the time between flashes that is also measured in picoseconds. This phenomenon (sonoluminescence or “SL”) is remarkable because it is the only means of generating picosecond flashes of light that does not use a laser and the input acoustic energy density must be concentrated by twelve orders of magnitude in order to produce light. Light scattering measurements indicate that the bubble wall is collapsing at more than 4 times the ambient speed of sound in the gas just prior to the light emitting moment when the gas has been compressed to a density determined by its van der Waals hard core. Experiments indicate that the collapse is remarkably spherical, water is the best fluid for SL, some noble gas is essential for stable SL, and that the light intensity increases as the ambient temperature is lowered. In the extremely stable experimental configuration consisting of an air bubble in water, measurements indicate that the bubble chooses an ambient radius that is not explained by mass diffusion. Experiments have not yet been able to map out the complete spectrum because above 6 eV it is obscured by the cutoff imposed by water, and furthermore experiments have only determined an upper bound on the flash widths. In addition to the above puzzles, the theory for the light emitting mechanism is still open. The scenario of a supersonic bubble collapse launching an imploding shock wave which ionizes the bubble contents so as to cause it to emit Bremsstrahlung radiation is the best candidate theory but it has not been shown how to extract from it the richness of this phenomenon. Most exciting is the issue of whether SL is a classical effect or whether Planck's constant should be invoked to explain how energy which enters a medium at the macroscopic scale holds together and focuses so as to be emitted at the microscopic scale.

  11. Joint effects of smoking and gene variants involved in sex steroid metabolism on hot flashes in late reproductive-age women.

    PubMed

    Butts, Samantha F; Freeman, Ellen W; Sammel, Mary D; Queen, Kaila; Lin, Hui; Rebbeck, Timothy R

    2012-06-01

    Although smoking has a known association with hot flashes, the factors distinguishing smokers at greatest risk for menopausal symptoms have not been well delineated. Recent evidence supports a relationship between menopausal symptoms and variants in several genes encoding enzymes that metabolize substrates such as sex steriods, xenobiotics, and catechols. It is currently not known whether the impact of smoking on hot flashes is modified by the presence of such variants. The objective of the study was to investigate the relationship between smoking and hot flash occurrence as a function of genetic variation in sex steroid-metabolizing enzymes. A cross-sectional analysis of data from the Penn Ovarian Aging study, an ongoing population-based cohort of late reproductive-aged women, was performed. Smoking behavior was characterized. Single-nucleotide polymorphisms in five genes were investigated: COMT Val158Met (rs4680), CYP1A2*1F (rs762551), CYP1B1*4 (Asn452Ser, rs1800440), CYP1B1*3 (Leu432Val, rs1056836), and CYP3A4*1B (rs2740574). Compared with nonsmokers, European-American COMT Val158Met double-variant carriers who smoked had increased odds of hot flashes [adjusted odds ratio (AOR) 6.15, 95% confidence interval (CI) 1.32-28.78)]; European-American COMT Val158Met double-variant carriers who smoked heavily had more frequent moderate or severe hot flashes than nonsmokers (AOR 13.7, 95% CI 1.2-154.9). European-American CYP 1B1*3 double-variant carriers who smoked described more frequent moderate or severe hot flashes than nonsmoking (AOR 20.6, 95% CI 1.64-257.93) and never-smoking (AOR 20.59, 95% CI 1.39-304.68) carriers, respectively. African-American single-variant CYP 1A2 carriers who smoked were more likely to report hot flashes than the nonsmoking carriers (AOR 6.16, 95% CI 1.11-33.91). This is the first report demonstrating the effects of smoking within the strata of gene variants involved in sex steroid metabolism on hot flashes in late reproductive-age women. The identification of individuals with a genetic susceptibility to smoking-related menopausal symptoms could contribute to interventions targeted at reducing reproductive morbidity both in the menopause and across the reproductive life course.

  12. Variable Thickness Liquid Crystal Films for High Repetition Rate Laser Applications

    NASA Astrophysics Data System (ADS)

    Poole, Patrick; Willis, Christopher; Cochran, Ginevra; Hanna, Randall; Andereck, C. David; Schumacher, Douglass

    2015-05-01

    The presentation of a clean target or target substrate at high repetition rates is of importance to a number of photoelectron spectroscopy and free electron laser applications, often in high vacuum environments. Additionally, high intensity laser facilities are approaching the 10 Hz shot rate at petawatt powers, but are currently unable to insert targets at these rates. We have developed liquid crystal films to address this need for high rep rate targets while preserving the planar geometry advantageous to many applications. The molecular ordering of liquid crystal is variable with temperature and can be manipulated to form a layered thin film. In this way temperature and volume control can be used to vary film thickness in vacuo and on-demand between 10 nm and over 10 μm. These techniques were previously applied to a single-shot ion acceleration experiment in, where target thickness critically determines the physics of the acceleration. Here we present an automatic film formation device that utilizes a linear sliding rail to form liquid crystal films within the aforementioned range at rates up to 0.1 Hz. The design ensures film formation location within 2 μm RMS, well within the Rayleigh range of even short f-number systems. Details of liquid crystal films and this target formation device will be shown as well as recent experimental data from the Scarlet laser facility at OSU. This work was supported by DARPA through a grant from AMRDEC.

  13. Microstructure and microchemistry of flash sintered K 0.5Na 0.5NbO 3

    DOE PAGES

    Corapcioglu, Gulcan; Gulgun, Mehmet Ali; Kisslinger, Kim; ...

    2016-04-30

    In this paper, flash sintering experiments were performed, for the first time, on sodium potassium niobate (KNN) ceramics. A theoretical density of 94% was achieved in 30 s under 250 V/cm electric-field at 990°C. These conditions are ~100°C lower and faster than the conventional sintering conditions. Grains tended to grow after 30 s. flash sintering duration under constant electric-field. Detailed microstructural and chemical investigations of the sample showed that there was inhomogenous Na, K distribution and it resembles a core–shell structure where K is more in the shell and Na is more in the core region. The inhomogenous distribution ofmore » Na and K was correlated with the doubling of the unit cell within the grain along 002 direction. Compositional equilibrium is achieved after a heat treatment at 1000°C for 4 h. Finally, the compositional variations appeared to have been linked to grain boundary melting during flash and consequent recrystallization as the sample cooled.« less

  14. On-shot characterization of single plasma mirror temporal contrast improvement

    NASA Astrophysics Data System (ADS)

    Obst, L.; Metzkes-Ng, J.; Bock, S.; Cochran, G. E.; Cowan, T. E.; Oksenhendler, T.; Poole, P. L.; Prencipe, I.; Rehwald, M.; Rödel, C.; Schlenvoigt, H.-P.; Schramm, U.; Schumacher, D. W.; Ziegler, T.; Zeil, K.

    2018-05-01

    We report on the setup and commissioning of a compact recollimating single plasma mirror (PM) for temporal contrast enhancement at the Draco 150 TW laser during laser-proton acceleration experiments. The temporal contrast with and without PM is characterized single-shot by means of self-referenced spectral interferometry with extended time excursion at unprecedented dynamic and temporal range. This allows for the first single-shot measurement of the PM trigger point, which is interesting for the quantitative investigation of the complex pre-plasma formation process at the surface of the target used for proton acceleration. As a demonstration of high contrast laser plasma interaction we present proton acceleration results with ultra-thin liquid crystal targets of ∼ 1 μm down to 10 nm thickness. Focus scans of different target thicknesses show that highest proton energies are reached for the thinnest targets at best focus. This indicates that the contrast enhancement is effective such that the acceleration process is not limited by target pre-expansion induced by laser light preceding the main laser pulse.

  15. Tailoring the heat transfer on the injection moulding cavity by plasma sprayed ceramic coatings

    NASA Astrophysics Data System (ADS)

    Bobzin, K.; Hopmann, Ch; Öte, M.; Knoch, M. A.; Alkhasli, I.; Dornebusch, H.; Schmitz, M.

    2017-03-01

    Inhomogeneous material shrinkage in injection moulding can cause warpage in thermoplastic components. To minimise the deformations of the injection moulding parts, the heat transfer during the cooling phase can be adjusted according to the local cooling demand on the surface of the mould cavity by means of plasma sprayed coatings with locally variable thermal resistance over the surface of the mould. Thermal resistance is a function of thermal conductivity and thickness of the coatings, where thermal conductivity of thermal barrier coatings can be adjusted by altering the chemical composition and the microstructure, which is depending on the thickness. This work evaluates the application of plasma sprayed coatings with variable thickness as thermal barrier coatings in the mould cavity. The thermal resistance of the coating and thereby the heat transfer from the melt into the mould will be influenced locally by varying the coating thickness over the cavity area according to the local cooling demand. Using the laser flash method, the thermal conduction of coatings with different thicknesses will be determined. On the basis of the experimentally determined thermal conduction, the effect of the coatings on the temperature field of the mould cavity will be numerically calculated and the required thickness distribution of the coating for an optimal temperature gradient will be determined.

  16. Storm Physics and Lightning Properties over Northern Alabama during DC3

    NASA Astrophysics Data System (ADS)

    Matthee, R.; Carey, L. D.; Bain, A. L.

    2013-12-01

    The Deep Convective Clouds and Chemistry (DC3) experiment seeks to examine the relationship between deep moist convection (DMC) and the production of nitrogen oxides (NOx) via lightning (LNOx). The focus of this study will be to examine integrated storm microphysics and lightning properties of DMC across northern Alabama (NA) during the DC3 campaign through use of polarimetric radar [UAHuntsville's Advanced Radar for Meteorological and Operational Radar (ARMOR)] and lightning mapping [National Aeronautical and Space Administration's (NASA) north Alabama Lightning Mapping Array (NA LMA)] platforms. Specifically, ARMOR and NA LMA are being used to explore the ability of radar inferred microphysical (e.g., ice mass, graupel volume) measurements to parameterize flash rates (F) and flash area for estimation of LNOX production in cloud resolving models. The flash area was calculated by using the 'convex hull' method. This method essentially draws a polygon around all the sources that comprise a flash. From this polygon, the convex hull area that describes the minimum polygon that circumscribes the flash extent is calculated. Two storms have been analyzed so far; one on 21 May 2012 (S1) and another on 11 June 2012 (S2), both of which were aircraft-penetrated during DC3. For S1 and S2, radar reflectivity (Z) estimates of precipitation ice mass (M) within the mixed-phase zone (-10°C to -40°C) were well correlated to the trend of lightning flash rate. However, a useful radar-based F parameterization must provide accurate quantification of rates in addition to proper trends. The difference reflectivity was used to estimate Z associated with ice and then a single Z-M relation was employed to calculate M in the mixed-phase zone. Using this approach it was estimated that S1 produced an order of magnitude greater M, but produced about a third of the total amount of flashes compared to S2. Expectations based on the non-inductive charging (NIC) theory suggest that the M-to-F ratio (M/F) should be stable from storm-to-storm, amongst other factors, all else being equal. Further investigation revealed that the mean mixed-phase Z was 11 dB higher in S1 compared to S2, suggesting larger diameters and lower concentrations of ice particles in S1. Reduction by an order of magnitude of the intercept parameter (N0) of an assumed exponential ice particle size distribution within the Z-M relation for S1 resulted in a proportional reduction in S1's inferred M and therefore a more comparable M/F ratio between the storms. Flash statistics between S1 and S2 revealed the following: S1 produced 1.92 flashes/minute and a total of 102 flashes, while S2 produced 3.45 flashes/minute and a total of 307 flashes. On average, S1 (S2) produced 212 (78) sources per flash and an average flash area of 89.53 km2 (53.85 km2). Thus, S1 produced fewer flashes, a lower F, but more sources per flash and larger flash areas as compared to S2. Ongoing analysis is exploring the tuning of N0 within the Z-M relation by the mean Z in the mixed-phase zone. The suitability of various M estimates and other radar properties (graupel volume, ice fluxes, anvil ice mass) for parameterizing F, flash area and LNOX will be investigated on different storm types across NA.

  17. 1st Joint European Conference on Therapeutic Targets and Medicinal Chemistry (TTMC 2015)

    PubMed Central

    Le Borgne, Marc; Haidar, Samer; Duval, Olivier; Wünsch, Bernhard; Jose, Joachim

    2015-01-01

    The European Conference on Therapeutic Targets and Medicinal Chemistry is a new two-day meeting on drug discovery that is focused on therapeutic targets and the use of tools to explore all fields of drug discovery and drug design such as molecular modelling, bioorganic chemistry, NMR studies, fragment screening, in vitro assays, in vivo assays, structure activity relationships, autodisplay. Abstracts of keynote lectures, plenary lectures, junior lectures, flash presentations, and posters presented during the meeting are collected in this report. PMID:26712767

  18. Areas for improvement in community optometry: flashes and floaters take priority.

    PubMed

    Duncan, Eilidh M; Cassie, Heather; Pooley, Janet; Elouafakoui, Paula; Prior, Maria; Gibb, Elizabeth; Ramsay, Craig; Young, Linda

    2018-07-01

    A common response to rising demand for healthcare is to extend the role of health professionals and the range of their service provision. Community optometry in Scotland is a recent example of this. Within this context of innovation and change there are challenges to ensuring quality in optometry practice. The purpose of this research is to establish what the priorities are for practice improvement within community optometry and to start a programme to inform strategies to improve practice. A four stage study was conducted: (1) a service-driven topic prioritisation exercise to identify priorities for optometry practice improvement; (2) a review of national and international guidance and UK protocols relating to the identified priority topic; (3) a national theory-based survey identifying current practice and the barriers and facilitators to the target behaviour; and (4) the identification of theory-based intervention options to improve practice. The Behaviour Change Wheel approach to behaviour change intervention development and Theoretical Domains Framework (TDF) provided the underlying theoretical framework. Stakeholders identified 'patients presenting with flashes and floaters' as an important priority for practice improvement. The decision about whether or not to refer patients on to secondary care for further examination is the target behaviour. Guidance for optometrists on this topic is lacking. Six TDF domains were related to the decision about whether or not to refer patients with flashes and floaters to secondary care - 'social influences', 'emotion', 'beliefs about capabilities', 'beliefs about consequences', 'behavioural regulation' and 'reinforcement'. This study has examined current practice in relation to the management of patients with flashes and floaters, identified the most salient targets for future strategies to improve optometry practice and highlighted what form these strategies may take. It demonstrates the use of a flexible, theory-informed approach, which can be used to engage with stakeholders and professionals to inform the design and development of efforts to improve practice in a variety of healthcare settings. © 2018 The Authors. Ophthalmic and Physiological Optics published by John Wiley & Sons Ltd on behalf of College of Optometrists.

  19. Bibliography on Cold Regions Science and Technology. Volume 52. Part 2,

    DTIC Science & Technology

    1998-12-01

    eng] 52-5087 spheric gases from antarctic ice cores. Gillaik, T., et al, in sediments and biota from four US arctic lakes. Allen-Gil, Study of the...1996,eng] 52-2678 52-690 Solomon , S., et at, [1997,eng] 52-879 Studies of cloud ice water path and optical thickness during Homogeneous ice...of clouds: a wave ota, D., et al, [1995,eng] 52-5364 flash rate. Solomon , R.C., [1997,eng] 52-1070 cloud case study . Ackerman, S.A., et al, [1998,eng

  20. Modeling midwave infrared muzzle flash spectra from unsuppressed and flash-suppressed large caliber munitions

    NASA Astrophysics Data System (ADS)

    Steward, Bryan J.; Perram, Glen P.; Gross, Kevin C.

    2012-07-01

    Time-resolved infrared spectra of firings from a 152 mm howitzer were acquired over an 1800-6000 cm-1 spectral range using a Fourier-transform spectrometer. The instrument collected primarily at 32 cm-1 spectral and 100 Hz temporal resolutions. Munitions included unsuppressed and chemically flash suppressed propellants. Secondary combustion occurred with unsuppressed propellants resulting in flash emissions lasting ˜100 ms and dominated by H2O and CO2 spectral structure. Non-combusting plume emissions were one-tenth as intense and approached background levels within 20-40 ms. A low-dimensional phenomenological model was used to reduce the data to temperatures, soot absorbances, and column densities of H2O, CO2, CH4, and CO. The combusting plumes exhibit peak temperatures of ˜1400 K, areas of greater than 32 m2, low soot emissivity of ˜0.04, with nearly all the CO converted to CO2. The non-combusting plumes exhibit lower temperatures of ˜1000 K, areas of ˜5 m2, soot emissivity of greater than 0.38 and CO as the primary product. Maximum fit residual relative to peak intensity are 14% and 8.9% for combusting and non-combusting plumes, respectively. The model was generalized to account for turbulence-induced variations in the muzzle plumes. Distributions of temperature and concentration in 1-2 spatial regions demonstrate a reduction in maximum residuals by 40%. A two-region model of combusting plumes provides a plausible interpretation as a ˜1550 K, optically thick plume core and ˜2550 K, thin, surface-layer flame-front. Temperature rate of change was used to characterize timescales and energy release for plume emissions. Heat of combustion was estimated to be ˜5 MJ/kg.

  1. Impact penetration experiments in teflon targets of variable thickness

    NASA Astrophysics Data System (ADS)

    Hoerz, F.; Cintala, M. J.; Bernhard, R. P.; See, T. H.

    1993-03-01

    Approximately 20.4 sq m of Teflon thermal blankets on the nonspinning Long Duration Exposure Facility (LDEF) were exposed to the orbital debris and micrometeoroid environment in low-Earth orbit (LEO) for approximately 5.7 years. Each blanket consisted of an outer layer (approximately 125 micron thick) of FEP Teflon that was backed by a vapor-deposited metal mirror (Inconel; less than 1 micron thick). The inner surface consisted of organic binders and Chemglaze thermal protective paint (approximately 50 micron thick) resulting in a somewhat variable, total blanket thickness of approximately 180 to 200 microns. There was at least one of these blankets, each exposing approximately 1.2 sq m of surface area, on nine of LDEF's 12 principal pointing directions, the exceptions being Rows 3, 9, and 12. As a consequence, these blankets represent a significant opportunity for micrometeoroid and debris studies, in general, and specifically they provide an opportunity to address those issues that require information about pointing direction (i.e., spatial density of impact events as a function of instrument orientation). During deintegration of the LDEF spacecraft at KSC, all penetration holes greater than or equal to 300 micron in diameter were documented and were recently synthesized in terms of spatial density as a function of LDEF viewing direction by. The present report describes ongoing cratering and penetration experiments in pure Teflon targets, which are intended to establish the relationships between crater or penetration-hole diameters and the associated projectile dimensions at laboratory velocities (i.e., 6 km/s). The ultimate objective of these efforts is to extract reliable mass-frequencies and associated fluxes of hypervelocity particles in LEO.

  2. Numerical and experimental study of the dynamics of a superheated jet

    NASA Astrophysics Data System (ADS)

    Sinha, Avick; Gopalakrishnan, Shivasubramanian; Balasubramanian, Sridhar

    2015-11-01

    Flash-boiling is a phenomenon where a liquid experiences low pressures in a system resulting in it getting superheated. The sudden drop in pressures results in accelerated expansion and violent vapour formation. Understanding the physics behind the jet disintegration and flash-boiling phenomenon is still an open problem, with applications in automotive and aerospace combustors. The behaviour of a flash-boiling jet is highly dependent on the input parameters, inlet temperature and pressure. In the present study, the external (outside nozzle) and the internal (inside nozzle) flow characteristics of the two-phase flow has been studied numerically and experimentally. The phase change from liquid to vapour takes place over a finite period of time, modeled sing Homogeneous Relaxation Model (HRM). In order to validate the numerical results, controlled experiments were performed. Optical diagnostic techniques such as Particle Image Velocimetry (PIV) and Shadowgraphy were used to study the flow characteristics. Spray angle, penetration depth, droplet spectra were obtained which provides a better understanding of the break-up mechanism. Linear stability analysis is performed to study the stability characteristics of the jet.

  3. Design of a Small-Scale Multi-Inlet Vortex Mixer for Scalable Nanoparticle Production and Application to the Encapsulation of Biologics by Inverse Flash NanoPrecipitation.

    PubMed

    Markwalter, Chester E; Prud'homme, Robert K

    2018-05-14

    Flash NanoPrecipitation (FNP) is a scalable approach to generate polymeric nanoparticles using rapid micromixing in specially-designed geometries such as a confined impinging jets (CIJ) mixer or a Multi-Inlet Vortex Mixer (MIVM). A major limitation of formulation screening using the MIVM is that a single run requires tens of milligrams of the therapeutic. To overcome this, we have developed a scaled-down version of the MIVM, requiring as little as 0.2 mg of therapeutic, for formulation screening. The redesigned mixer can then be attached to pumps for scale-up of the identified formulation. It was shown that Reynolds Number allowed accurate scaling between the two MIVM designs. The utility of the small-scale MIVM for formulation development was demonstrated through the encapsulation of a number of hydrophilic macromolecules using inverse Flash NanoPrecipitation with target loadings as high as 50% by mass. Copyright © 2018. Published by Elsevier Inc.

  4. Is it a bird? Is it a plane? Ultra-rapid visual categorisation of natural and artifactual objects.

    PubMed

    VanRullen, R; Thorpe, S J

    2001-01-01

    Visual processing is known to be very fast in ultra-rapid categorisation tasks where the subject has to decide whether a briefly flashed image belongs to a target category or not. Human subjects can respond in under 400 ms, and event-related-potential studies have shown that the underlying processing can be done in less than 150 ms. Monkeys trained to perform the same task have proved even faster. However, most of these experiments have only been done with biologically relevant target categories such as animals or food. Here we performed the same study on human subjects, alternating between a task in which the target category was 'animal', and a task in which the target category was 'means of transport'. These natural images of clearly artificial objects contained targets as varied as cars, trucks, trains, boats, aircraft, and hot-air balloons. However, the subjects performed almost identically in both tasks, with reaction times not significantly longer in the 'means of transport' task. These reaction times were much shorter than in any previous study on natural-image processing. We conclude that, at least for these two superordinate categories, the speed of ultra-rapid visual categorisation of natural scenes does not depend on the target category, and that this processing could rely primarily on feed-forward, automatic mechanisms.

  5. Modeling Studies of Inhomogeneity Effects during Laser Flash Photolysis Experiments: A Reaction-Diffusion Approach.

    PubMed

    Dóka, Éva; Lente, Gábor

    2017-04-13

    This work presents a rigorous mathematical study of the effect of unavoidable inhomogeneities in laser flash photolysis experiments. There are two different kinds of inhomegenities: the first arises from diffusion, whereas the second one has geometric origins (the shapes of the excitation and detection light beams). Both of these are taken into account in our reported model, which gives rise to a set of reaction-diffusion type partial differential equations. These equations are solved by a specially developed finite volume method. As an example, the aqueous reaction between the sulfate ion radical and iodide ion is used, for which sufficiently detailed experimental data are available from an earlier publication. The results showed that diffusion itself is in general too slow to influence the kinetic curves on the usual time scales of laser flash photolysis experiments. However, the use of the absorbances measured (e.g., to calculate the molar absorption coefficients of transient species) requires very detailed mathematical consideration and full knowledge of the geometrical shapes of the excitation laser beam and the separate detection light beam. It is also noted that the usual pseudo-first-order approach to evaluating the kinetic traces can be used successfully even if the usual large excess condition is not rigorously met in the reaction cell locally.

  6. Introduction to the Laser-HANE Experiment and Summary of Low-Pressure Interaction Results.

    DTIC Science & Technology

    1984-02-22

    NUMBER ORGANIZATION Efi .FFUcablej Defense Nuclear Agency r____________________ S. ADDRESS IC0lY.7f ande~ ZIP Code# 10. SOURCE O FUNDING NOS. PROGRAM...of Atmospheric Effects (RAAE), initiated a laser-target HANE-simulation experiment at the Naval Research Laboratory in early 1982. The objective of...The experiment involves focusing beams from the NRL-Pharos II Nd-laser (1.05 ljm wavelength) onto a small (< 1 rmm dia, few-microns thick foil ) solid

  7. Three-dimensional FLASH Laser Radar Range Estimation via Blind Deconvolution

    DTIC Science & Technology

    2009-10-01

    scene can result in errors due to several factors including the optical spatial impulse response, detector blurring, photon noise , timing jitter, and...estimation error include spatial blur, detector blurring, noise , timing jitter, and inter-sample targets. Unlike previous research, this paper ac- counts...for pixel coupling by defining the range image mathematical model as a 2D convolution between the system spatial impulse response and the object (target

  8. Flash melting of tantalum in a diamond cell to 85 GPa

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Karandikar, Amol; Boehler, Reinhard

    2016-02-09

    Here, we demonstrate a new level of precision in measuring melting temperatures at high pressure using laser flash-heating followed by Scanning Electron Microscopy and Focused Ion Beam Milling. Furthermore, the new measurements on tantalum put unprecedented constraints on its highly debated melting slope, calling for a reevaluation of theoretical, shock compression and diamond cell approaches to determine melting at high pressure. X-ray analysis of the recovered samples confirmed the absence of chemical reactions, which likely played a significant role in previous experiments.

  9. Unconscious response priming during continuous flash suppression

    PubMed Central

    Grassini, Simone

    2018-01-01

    Continuous flash suppression (CFS) has become a popular tool for studying unconscious processing, but the level at which unconscious processing of visual stimuli occurs under CFS is not clear. Response priming is a robust and well-understood phenomenon, in which the prime stimulus facilitates overt responses to targets if the prime and target are associated with the same response. We used CFS to study unconscious response priming of shape: arrows with left or right orientation served as primes and targets. The prime was presented near the limen of consciousness and each trial was followed by subjective rating of visibility and a forced-choice response concerning the orientation of the prime in counterbalanced order. In trials without any reported awareness of the presence of the prime, discrimination of the prime’s orientation was at chance level. However, priming was elicited in such unconscious trials. Unconscious priming was not influenced by the prime-target onset-asynchrony (SOA)/prime duration, whereas conscious processing, as indicated by the enhanced discriminability of the prime’s orientation and conscious priming, increased at the longest SOAs/prime durations. These results show that conscious and unconscious processes can be dissociated with CFS and that CFS-masking does not completely suppress unconscious visual processing of shape. PMID:29401503

  10. ACOUSTIC SIGNATURES OF THE HELIUM CORE FLASH

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bildsten, Lars; Paxton, Bill; Moore, Kevin

    2012-01-15

    All evolved stars with masses M {approx}< 2 M{sub Sun} undergo an initiating off-center helium core flash in their M{sub c} Almost-Equal-To 0.48 M{sub Sun} He core as they ascend the red giant branch (RGB). This off-center flash is the first of a few successive helium shell subflashes that remove the core electron degeneracy over 2 Myr, converting the object into a He-burning star. Though characterized by Thomas over 40 years ago, this core flash phase has yet to be observationally probed. Using the Modules for Experiments in Stellar Astrophysics (MESA) code, we show that red giant asteroseismology enabled bymore » space-based photometry (i.e., Kepler and CoRoT) can probe these stars during the flash. The rapid ({approx}< 10{sup 5} yr) contraction of the red giant envelope after the initiating flash dramatically improves the coupling of the p-modes to the core g-modes, making the detection of l = 1 mixed modes possible for these 2 Myr. This duration implies that 1 in 35 stars near the red clump in the H-R diagram will be in their core flash phase. During this time, the star has a g-mode period spacing of {Delta}P{sub g} Almost-Equal-To 70-100 s, lower than the {Delta}P{sub g} Almost-Equal-To 250 s of He-burning stars in the red clump, but higher than the RGB stars at the same luminosity. This places them in an underpopulated part of the large frequency spacing ({Delta}{nu}) versus {Delta}P{sub g} diagram that should ease their identification among the thousands of observed red giants.« less

  11. Ballistic Experiments with Titanium and Aluminum Targets

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gogolewski, R.; Morgan, B.R.

    1999-11-23

    During the course of the project we conducted two sets of fundamental experiments in penetration mechanics in the LLNL Terminal Ballistics Laboratory of the Physics Directorate. The first set of full-scale experiments was conducted with a 14.5mm air propelled launcher. The object of the experiments was to determine the ballistic limit speed of 6Al-4V-alloy titanium, low fineness ratio projectiles centrally impacting 2024-T3 alloy aluminum flat plates and the failure modes of the projectiles and the targets. The second set of one-third scale experiments was conducted with a 14.5mm powder launcher. The object of these experiments was to determine the ballisticmore » limit speed of 6Al-4V alloy titanium high fineness ratio projectiles centrally impacting 6Al-4V alloy titanium flat plates and the failure modes of the projectiles and the target. We employed radiography to observe a projectile just before and after interaction with a target plate. Early on, we employed a non-damaging ''soft-catch'' technique to capture projectiles after they perforated targets. Once we realized that a projectile was not damaged during interaction with a target, we used a 4-inch thick 6061-T6-alloy aluminum witness block with a 6.0-inch x 6.0-inch cross-section to measure projectile residual penetration. We have recorded and tabulated below projectile impact speed, projectile residual (post-impact) speed, projectile failure mode, target failure mode, and pertinent comments for the experiments. The ballistic techniques employed for the experiments are similar to those employed in an earlier study.« less

  12. Polyurethane Foam Impact Experiments and Simulations

    NASA Astrophysics Data System (ADS)

    Kipp, M. E.; Chhabildas, L. C.; Reinhart, W. D.; Wong, M. K.

    1999-06-01

    Uniaxial strain impact experiments with a rigid polyurethane foam of nominal density 0.22g/cc are reported. A 6 mm thick foam impactor is mounted on the face of a projectile and impacts a thin (1 mm) target plate of aluminum or copper, on which the rear free surface velocity history is acquired with a VISAR. Impact velocities ranged from 300 to 1500 m/s. The velocity record monitors the initial shock from the foam transmitted through the target, followed by a reverberation within the target plate as the wave interacts with the compressed foam at the impact interface and the free recording surface. These one-dimensional uniaxial strain impact experiments were modeled using a traditional p-alpha porous material model for the distended polyurethane, which generally captured the motion imparted to the target by the foam. Some of the high frequency aspects of the data, reflecting the heterogeneous nature of the foam, can be recovered with computations of fully 3-dimensional explicit representations of this porous material.

  13. Exploring Chondrule and CAI Rims Using Micro- and Nano-Scale Petrological and Compositional Analysis

    NASA Astrophysics Data System (ADS)

    Cartwright, J. A.; Perez-Huerta, A.; Leitner, J.; Vollmer, C.

    2017-12-01

    As the major components within chondrites, chondrules (mm-sized droplets of quenched silicate melt) and calcium-aluminum-rich inclusions (CAI, refractory) represent the most abundant and the earliest materials that solidified from the solar nebula. However, the exact formation mechanisms of these clasts, and whether these processes are related, remains unconstrained, despite extensive petrological and compositional study. By taking advantage of recent advances in nano-scale tomographical techniques, we have undertaken a combined micro- and nano-scale study of CAI and chondrule rim morphologies, to investigate their formation mechanisms. The target lithologies for this research are Wark-Lovering rims (WLR), and fine-grained rims (FGR) around CAIs and chondrules respectively, present within many chondrites. The FGRs, which are up to 100 µm thick, are of particular interest as recent studies have identified presolar grains within them. These grains predate the formation of our Solar System, suggesting FGR formation under nebular conditions. By contrast, WLRs are 10-20 µm thick, made of different compositional layers, and likely formed by flash-heating shortly after CAI formation, thus recording nebular conditions. A detailed multi-scale study of these respective rims will enable us to better understand their formation histories and determine the potential for commonality between these two phases, despite reports of an observed formation age difference of up to 2-3 Myr. We are using a combination of complimentary techniques on our selected target areas: 1) Micro-scale characterization using standard microscopic and compositional techniques (SEM-EBSD, EMPA); 2) Nano-scale characterization of structures using transmission electron microscopy (TEM) and elemental, isotopic and tomographic analysis with NanoSIMS and atom probe tomography (APT). Preliminary nano-scale APT analysis of FGR morphologies within the Allende carbonaceous chondrite has successfully discerned complex chondritic mineralogies and compositional differences across boundaries, which is one of the first applications of in-situ APT techniques to chondrites. Further data reduction will allow us to characterize the exact phases present, and further chondrite analyses are in progress.

  14. 19 F(α,n) thick target yield from 3.5 to 10.0 MeV

    DOE PAGES

    Norman, E.B.; Chupp, T.E.; Lesko, K.T.; ...

    2015-09-01

    Using a target of PbF2, the thick-target yield from the 19F(α,n) reaction was measured from Eα=3.5–10 MeV. From these results, we infer the thick-target neutron yields from targets of F2 and UF6 over this same alpha-particle energy range.

  15. Determination of the temperature of bremsstrahlung photon generated by ultraintense laser using various thickness attenuators

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hasegawa, Shuichi; Takashima, Ryuta; Todoriki, Masaru

    2011-03-15

    We evaluate the simplified method using the Lambert-Beer law to measure the temperature of bremsstrahlung photon generated by an ultraintense laser. Analytical values are compared to the results of the Monte Carlo calculation of GEANT4 and they agreed very well on the condition of the appropriate distance between the attenuator and the detector. We performed the experiment to measure the temperature of bremsstrahlung x-ray emitted from a metal target irradiated by a Ti:sapphire laser with 76 mJ, 72 fs, 2.2 x 10{sup 18} W/cm{sup 2}. For a Cu target of 30 {mu}m thick, the photon temperature was reasonably determined tomore » be 0.18 MeV, which is in good agreement with previous studies.« less

  16. Liquid-phase explosive crystallization of electron-beam-evaporated a-Si films induced by flash lamp annealing

    NASA Astrophysics Data System (ADS)

    Ohdaira, Keisuke; Matsumura, Hideki

    2013-01-01

    We succeed in the formation of micrometer-order-thick polycrystalline silicon (poly-Si) films through the flash-lamp-induced liquid-phase explosive crystallization (EC) of precursor a-Si films prepared by electron-beam (EB) evaporation. The velocity of the explosive crystallization (vEC) is estimated to be ˜14 m/s, which is close to the velocity of the liquid-phase epitaxy (LPE) of Si at a temperature around the melting point of a-Si of 1418 K. Poly-Si films formed have micrometer-order-long grains stretched along a lateral crystallization direction, and X-ray diffraction (XRD) and electron diffraction pattern measurements reveal that grains in poly-Si films tend to have a particular orientation. These features are significantly different from our previous results: the formation of poly-Si films containing randomly-oriented 10-nm-sized fine grains formed from a-Si films prepared by catalytic chemical vapor deposition (Cat-CVD) or sputtering. One possible reason for the emergence of a different EC mode in EB-evaporated a-Si films is the suppression of solid-phase nucleation (SPN) during Flash Lamp Annealing (FLA) due to tensile stress which precursor a-Si films originally hold. Poly-Si films formed from EB-evaporated a-Si films would contribute to the realization of high-efficiency thin-film poly-Si solar cells because of large and oriented grains.

  17. Thermal conductivity of ZrO2-4mol%Y2O3 thin coatings by pulsed thermal imaging method

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jang, Byung-Koog; Sun, Jiangang; Kim, Seongwon

    Thin ZrO2-4mol% Y2O3 coatings were deposited onto ZrO2 substrates by electron beam-physical vapor deposition. The coated samples revealed a feather-like columnar microstructure. The main phase of the ZrO2-4mol% Y2O3 coatings was the tetragonal phase. To evaluate the influence of the coating’s thickness on the thermal conductivity of thin ZrO2-4mol% Y2O3 coatings, the pulsed thermal imaging method was employed to obtain the thermal conductivity of the coating layer in the two-layer (coating and substrate) samples with thickness between 56 and 337 micrometers. The thermal conductivity of the coating layer was successfully evaluated and compared well with those obtained by the lasermore » flash method for similar coatings. The thermal conductivity of coatings shows an increasing tendency with an increase in the coating’s thickness.« less

  18. Synchronizing flash-melting in a diamond cell with synchrotron X ray diffraction (XRD)

    NASA Astrophysics Data System (ADS)

    Karandikar, Amol; Boehler, Reinhard; Meng, Yue; Rod, Eric; Shen, Guoyin

    2013-06-01

    The major challenges in measuring melting temperatures in laser heated diamond cells are sample instability, thermal runaway and chemical reactions. To circumvent these problems, we developed a ``flash heating'' method using a modulated CW fiber laser and fast X ray detection capability at APS (Pilatus 1M detector). As an example, Pt spheres of 5 micron diameter were loaded in a single crystal sapphire encapsulation in the diamond cell at 65 GPa and heated in a single flash heating event for 20 ms to reach a desired temperature. A CCD spectrometer and the Pilatus were synchronized to measure the temperature and the XRD signal, respectively, when the sample reached the thermal steady state. Each successive flash heating was done at a higher temperature. The integrated XRD pattern, collected during and after (300 K) each heating, showed no chemical reaction up to 3639 K, the highest temperature reached in the experiment. Pt111 and 200 peak intensity variation showed gradual recrystalization and complete diminishing at about 3600 K, indicating melting. Thus, synchronized flash heating with novel sample encapsulation circumvents previous notorious problems and enables accurate melting temperature measurement in the diamond cell using synchrotron XRD probe. Affiliation 2: Geowissenschaeften, Goethe-Universitaet, Altenhoeferallee 1, D-60438 Frankfurt a.M., Germany.

  19. HARP targets pion production cross section and yield measurements. Implications for MiniBooNE neutrino flux

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wickremasinghe, Don Athula Abeyarathna

    2015-07-01

    The prediction of the muon neutrino flux from a 71.0 cm long beryllium target for the MiniBooNE experiment is based on a measured pion production cross section which was taken from a short beryllium target (2.0 cm thick - 5% nuclear interaction length) in the Hadron Production (HARP) experiment at CERN. To verify the extrapolation to our longer target, HARP also measured the pion production from 20.0 cm and 40.0 cm beryllium targets. The measured production yields, d 2N π± (p; θ )=dpd Ω, on targets of 50% and 100% nuclear interaction lengths in the kinematic rage of momentum frommore » 0.75 GeV/c to 6.5 GeV/c and the range of angle from 30 mrad to 210 mrad are presented along with an update of the short target cross sections. The best fitted extended Sanford-Wang (SW) model parameterization for updated short beryllium target π + production cross section is presented. Yield measurements for all three targets are also compared with that from the Monte Carlo predictions in the MiniBooNE experiment for different SW parameterization. The comparisons of v μ flux predictions for updated SW model is presented.« less

  20. Microdose Induced Data Loss on Floating Gate Memories

    NASA Technical Reports Server (NTRS)

    Guertin, Steven M.; Nguyen, Duc M.; Patterson, Jeffrey D.

    2006-01-01

    Heavy ion irradiation of flash memories shows loss of stored data. The fluence dependence is indicative of microdose effects. Other qualitative factors identifying the effect as microdose are discussed. The data is presented, and compared to statistical results of a microdose target-based model.

  1. Advantage of hole stimulus in rivalry competition.

    PubMed

    Meng, Qianli; Cui, Ding; Zhou, Ke; Chen, Lin; Ma, Yuanye

    2012-01-01

    Mounting psychophysical evidence suggests that early visual computations are sensitive to the topological properties of stimuli, such as the determination of whether the object has a hole or not. Previous studies have demonstrated that the hole feature took some advantages during conscious perception. In this study, we investigate whether there exists a privileged processing for hole stimuli during unconscious perception. By applying a continuous flash suppression paradigm, the target was gradually introduced to one eye to compete against a flashed full contrast Mondrian pattern which was presented to the other eye. This method ensured that the target image was suppressed during the initial perceptual period. We compared the initial suppressed duration between the stimuli with and without the hole feature and found that hole stimuli required less time than no-hole stimuli to gain dominance against the identical suppression noise. These results suggest the hole feature could be processed in the absence of awareness, and there exists a privileged detection of hole stimuli during suppressed phase in the interocular rivalry.

  2. Laser Driven Compression Equations of State and Hugoniot Pressure Measurements in Thick Solid Metallic Targets at ˜0.17-13 TW/cm2

    NASA Astrophysics Data System (ADS)

    Remo, John L.

    2010-10-01

    An electro-optic laser probe was developed to obtain parameters for high energy density equations of state (EoS), Hugoniot pressures (PH), and strain rates for high energy density laser irradiation intensity, I, experiments at ˜170 GW/cm2 (λ = 1064 nm) to ˜13 TW/cm2 (λ = 527 nm) on Al, Cu, Ti, Fe, Ni metal targets in a vacuum. At I ˜7 TW/cm2 front surface plasma pressures and temperatures reached 100's GPa and over two million K. Rear surface PH ranged from 7-120 GPa at average shock wave transit velocities 4.2-8.5 km/s, depending on target thickness and I. A surface plasma compression ˜100's GPa generated an impulsive radial expanding shock wave causing compression, rarefactions, and surface elastic and plastic deformations depending on I. A laser/fiber optic system measured rear surface shock wave emergence and particle velocity with ˜3 GHz resolution by monitoring light deflection from diamond polished rear surfaces of malleable metallic targets, analogous to an atomic force microscope. Target thickness, ˜0.5-2.9 mm, prevented front surface laser irradiation penetration, due to low radiation skin depth, from altering rear surface reflectivity (refractive index). At ˜10 TW electromagnetic plasma pulse noise generated from the target chamber overwhelmed detector signals. Pulse frequency analysis using Moebius loop antennae probed transient noise characteristics. Average shock (compression) and particle (rear surface displacement) velocity measurements determined rear surface PH and GPa) EoS that are compared with gas guns.

  3. Neurobehavioral and neurometabolic (SPECT) correlates of paranormal information: involvement of the right hemisphere and its sensitivity to weak complex magnetic fields.

    PubMed

    Roll, W G; Persinger, M A; Webster, D L; Tiller, S G; Cook, C M

    2002-02-01

    Experiments were designed to help elucidate the neurophysiological correlates for the experiences reported by Sean Harribance. For most of his life he has routinely experienced "flashes of images" of objects that were hidden and of accurate personal information concerning people with whom he was not familiar. The specificity of details for target pictures of people was correlated positively with the proportion of occipital alpha activity. Results from a complete neuropsychological assessment, Single Photon Emission Computed Tomography (SPECT), and screening electroencephalography suggested that his experiences were associated with increased activity within the parietal lobe and occipital regions of the right hemisphere. Sensed presences (subjectively localized to his left side) were evoked when weak, magnetic fields, whose temporal structure simulated long-term potentiation in the hippocampus, were applied over his right temporoparietal lobes. These results suggest that the phenomena attributed to paranormal or "extrasensory" processes are correlated quantitatively with morphological and functional anomalies involving the right parietotemporal cortices (or its thalamic inputs) and the hippocampal formation.

  4. Results of TLE and TGF Observation in RELEC Experiment onboard "Vernov" Mission

    NASA Astrophysics Data System (ADS)

    Klimov, Pavel; Garipov, Gali; Klimov, Stanislav; Rothkaehl, Hanna; Khrenov, Boris; Pozanenko, Alexei; Morozenko, Violetta; Iyudin, Anatoly; Bogomolov, Vitalij V.; Svertilov, Sergey; Panasyuk, Mikhail; Saleev, Kirill; Kaznacheeva, Margarita; Maximov, Ivan

    2016-07-01

    "Vernov" satellite with RELEC experiment onboard was launched on 2014 July, 8 into a polar solar-synchronous orbit. The payload includes DUV ultraviolet and red photometer and DRGE gamma-ray spectrometer providing measurements in 10-3000 keV energy range with four detectors. Both instruments directed to the atmosphere. Total area of DRGE detectors is ˜500 cm ^{2}. The data were recorded both in monitoring and gamma by gamma modes with timing accuracy ˜15 μs. Several TGF candidates with 10-40 gammas in a burst with duration <1 ms were detected. Analysis of data from other instruments on-board "Vernov" satellite shows the absence of significant electromagnetic pulses around correspondent time moments. Comparison with a world wide lightning location network (WWLLN) data base also indicates that there were no thunderstorms connected with most of detected TGF candidates. Possible connection of TGF candidates with electron precipitations is discussed. Observations of transient luminous events (TLEs) were made in UV (240-400 nm) and IR (>610 nm) wavelength bands. More than 8 thousands of flashes with duration between 1 and 128 ms were detected from the atmosphere. Time profiles of detected flashes are very diverse. There are single peak events with significant UV and IR signal, multi-peak structures visible in the both UV and IR channels and very complicated events mixed from UV and IR signals and UV flashes which can continue even during the whole waveform. In addition, there are flashes of various temporal duration and structure measured only in UV wavelength range. Number of UV photons released in the atmosphere varies in a wide range from 10 ^{20} to 10 ^{26}. Apart from the events detected in the thunderstorm regions over the continents, many flashes were observed outside of thunderstorm areas, above the ocean and even at rather high latitudes. Such events are not associated with the thunderstorm and lightning activity measured by WWLLN. Various types of UV and IR flashes measurements and their interpretation, geographical, energy and spectral distribution are presented and discussed.

  5. Design, construction and performance evaluation of the target tissue thickness measurement system in intraoperative radiotherapy for breast cancer

    NASA Astrophysics Data System (ADS)

    Yazdani, Mohammad Reza; Setayeshi, Saeed; Arabalibeik, Hossein; Akbari, Mohammad Esmaeil

    2017-05-01

    Intraoperative electron radiation therapy (IOERT), which uses electron beams for irradiating the target directly during the surgery, has the advantage of delivering a homogeneous dose to a controlled layer of tissue. Since the dose falls off quickly below the target thickness, the underlying normal tissues are spared. In selecting the appropriate electron energy, the accuracy of the target tissue thickness measurement is critical. In contrast to other procedures applied in IOERT, the routine measurement method is considered to be completely traditional and approximate. In this work, a novel mechanism is proposed for measuring the target tissue thickness with an acceptable level of accuracy. An electronic system has been designed and manufactured with the capability of measuring the tissue thickness based on the recorded electron density under the target. The results indicated the possibility of thickness measurement with a maximum error of 2 mm for 91.35% of data. Aside from system limitation in estimating the thickness of 5 mm phantom, for 88.94% of data, maximum error is 1 mm.

  6. Validity, cut-points, and minimally important differences for two hot flash-related daily interference scales.

    PubMed

    Carpenter, Janet S; Bakoyannis, Giorgos; Otte, Julie L; Chen, Chen X; Rand, Kevin L; Woods, Nancy; Newton, Katherine; Joffe, Hadine; Manson, JoAnn E; Freeman, Ellen W; Guthrie, Katherine A

    2017-08-01

    To conduct psychometric analyses to condense the Hot Flash-Related Daily Interference Scale (HFRDIS) into a shorter form termed the Hot Flash Interference (HFI) scale; evaluate cut-points for both scales; and establish minimally important differences (MIDs) for both scales. We analyzed baseline and postrandomization patient-reported data pooled across three randomized trials aimed at reducing vasomotor symptoms (VMS) in 899 midlife women. Trials were conducted across five MsFLASH clinical sites between July 2009 and October 2012. We eliminated HFRDIS items based on experts' content validity ratings and confirmatory factor analysis, and evaluated cut-points and established MIDs by mapping HFRDIS and HFI to other measures. The three-item HFI (interference with sleep, mood, and concentration) demonstrated strong internal consistency (alphas of 0.830 and 0.856), showed good fit to the unidimensional "hot flash interference factor," and strong convergent validity with HFRDIS scores, diary VMS, and menopausal quality of life. For both scales, cut-points of mild (0-3.9), moderate (4-6.9), and severe (7-10) interference were associated with increasing diary VMS ratings, sleep, and anxiety. The average MID was 1.66 for the HFRDIS and 2.34 for the HFI. The HFI is a brief assessment of VMS interference and will be useful in busy clinics to standardize VMS assessment or in research studies where response burden may be an issue. The scale cut-points and MIDs should prove useful in targeting those most in need of treatment, monitoring treatment response, and interpreting existing and future research findings.

  7. An X-ray monitor for measurement of a titanium tritide target thickness

    NASA Technical Reports Server (NTRS)

    Alger, D. L.; Steinberg, R.

    1972-01-01

    An X-ray device capable of measuring titanium tritide film thickness from 0.1 to 30 micrometers has been built and tested. The monitor was designed for use in a rotating target system which used thick targets and incorporated a sputtering electrode to remove depleted layers from the target surface. The thickness measurement can be done in the presence of an intense background of bremsstrahlung and characteristic titanium X-radiation. A measurement can be accomplished in situ in two hours with reasonable accuracy.

  8. New Developments in Proton Radiography at the Los Alamos Neutron Science Center (LANSCE)

    DOE PAGES

    Morris, C. L.; Brown, E. N.; Agee, C.; ...

    2015-12-30

    An application of nuclear physics, a facility for using protons for flash radiography, was developed at the Los Alamos Neutron Science Center (LANSCE). Protons have proven far superior to high energy x-rays for flash radiography because of their long mean free path, good position resolution, and low scatter background. Although this facility is primarily used for studying very fast phenomena such as high explosive driven experiments, it is finding increasing application to other fields, such as tomography of static objects, phase changes in materials and the dynamics of chemical reactions. The advantages of protons are discussed, data from some recentmore » experiments will be reviewed and concepts for new techniques are introduced.« less

  9. [Design and implementation of controlling smart car systems using P300 brain-computer interface].

    PubMed

    Wang, Jinjia; Yang, Chengjie; Hu, Bei

    2013-04-01

    Using human electroencephalogram (EEG) to control external devices in order to achieve a variety of functions has been focus of the field of brain-computer interface (BCI) research. P300 is experiments which stimulate the eye to produce EEG by using letters flashing, and then identify the corresponding letters. In this paper, some improvements based on the P300 experiments were made??. Firstly, the matrix of flashing letters were modified into words which represent a certain sense. Secondly, the BCI2000 procedures were added with the corresponding source code. Thirdly, the smart car systems were designed using the radiofrequency signal. Finally it was realized that the evoked potentials were used to control the state of the smart car.

  10. Shock timing measurements in DT ice layers

    NASA Astrophysics Data System (ADS)

    Robey, H. F.; Celliers, P. M.; Moody, J. D.; Sater, J.; Parham, T.; Kozioziemski, B.; Dylla-Spears, R. J.; Ross, J. S.; Lepape, S.; Ralph, J. E.; Berzak Hopkins, L. F.; Kroll, J. J.; Yoxall, B. E.; Hamza, A. V.; Boehly, T. R.; Nikroo, A.; Landen, O. L.; Edwards, M. J.

    2013-10-01

    Shock timing experiments on the National Ignition Facility (NIF) are routinely conducted using the keyhole target geometry, in which the strength and timing of multiple shocks are measured in a liquid-deuterium (D2) filled capsule interior. These targets have recently been modified to improve the surrogacy to ignition implosions by replacing the standard, continuous liquid D2 capsule fill with a deuterium-tritium (DT) ice layer with a central DT gas fill. These experiments remove any possible material surrogacy difference between D2 and DT as well as incorporating the physics of multiple shock release and recompression events from an ice layer of finite thickness, an effect that is absent in the liquid-filled targets. Experimental results and comparisons with numerical simulation are presented. Prepared by LLNL under Contract DE-AC52-07NA27344.

  11. Description of an Audio-Based Paced Respiration Intervention for Vasomotor Symptoms

    PubMed Central

    Burns, Debra S.; Drews, Michael R.; Carpenter, Janet S.

    2013-01-01

    Millions of women experience menopause-related hot flashes or flushes that may have a negative effect on their quality of life. Hormone therapy is an effective treatment, however, it may be contraindicated or unacceptable for some women based on previous health complications or an undesirable risk–benefit ratio. Side effects and the unacceptability of hormone therapy have created a need for behavioral interventions to reduce hot flashes. A variety of complex, multimodal behavioral, relaxation-based interventions have been studied with women (n = 88) and showed generally favorable results. However, currently extensive resource commitments reduce the translation of these interventions into standard care. Slow, deep breathing is a common component in most interventions and may be the active ingredient leading to reduced hot flashes. This article describes the content of an audio-based program designed to teach paced breathing to reduce hot flashes. Intervention content was based on skills training theory and music entrainment. The audio intervention provides an efficient way to deliver a breathing intervention that may be beneficial to other clinical populations. PMID:23914283

  12. Hy-wire and fast electric field change measurements near an isolated thunderstorm, appendix C

    NASA Technical Reports Server (NTRS)

    Holzworth, R. H.; Levine, D. M.

    1983-01-01

    Electric field measurements near an isolated thunderstorm at 6.4 km distance are presented from both a tethered balloon experiment called Hy-wire and also from ground based fast and slow electric field change systems. Simultaneous measurements were made of the electric fields during several lightning flashes at the beginning of the storm which the data clearly indicate were cloud-to-ground flashes. In addition to providing a comparison between the Hy-wire technique for measuring electric fields and more traditional methods, these data are interesting because the lightning flashes occurred prior to changes in the dc electric field, although Hy-wire measured changes in the dc field of up to 750 V/m in the direction opposite to the fair weather field a short time later. Also, the dc electric field was observed to decay back to its preflash value after each flash. The data suggest that Hy-wire was at the field reversal distance from this storm and suggest the charge realignment was taking place in the cloud with a time constant on the order of 20 seconds.

  13. Joint Effects of Smoking and Gene Variants Involved in Sex Steroid Metabolism on Hot Flashes in Late Reproductive-Age Women

    PubMed Central

    Freeman, Ellen W.; Sammel, Mary D.; Queen, Kaila; Lin, Hui; Rebbeck, Timothy R.

    2012-01-01

    Background: Although smoking has a known association with hot flashes, the factors distinguishing smokers at greatest risk for menopausal symptoms have not been well delineated. Recent evidence supports a relationship between menopausal symptoms and variants in several genes encoding enzymes that metabolize substrates such as sex steriods, xenobiotics, and catechols. It is currently not known whether the impact of smoking on hot flashes is modified by the presence of such variants. Objective: The objective of the study was to investigate the relationship between smoking and hot flash occurrence as a function of genetic variation in sex steroid-metabolizing enzymes. Methods: A cross-sectional analysis of data from the Penn Ovarian Aging study, an ongoing population-based cohort of late reproductive-aged women, was performed. Smoking behavior was characterized. Single-nucleotide polymorphisms in five genes were investigated: COMT Val158Met (rs4680), CYP1A2*1F (rs762551), CYP1B1*4 (Asn452Ser, rs1800440), CYP1B1*3 (Leu432Val, rs1056836), and CYP3A4*1B (rs2740574). Results: Compared with nonsmokers, European-American COMT Val158Met double-variant carriers who smoked had increased odds of hot flashes [adjusted odds ratio (AOR) 6.15, 95% confidence interval (CI) 1.32–28.78)]; European-American COMT Val158Met double-variant carriers who smoked heavily had more frequent moderate or severe hot flashes than nonsmokers (AOR 13.7, 95% CI 1.2–154.9). European-American CYP 1B1*3 double-variant carriers who smoked described more frequent moderate or severe hot flashes than nonsmoking (AOR 20.6, 95% CI 1.64–257.93) and never-smoking (AOR 20.59, 95% CI 1.39–304.68) carriers, respectively. African-American single-variant CYP 1A2 carriers who smoked were more likely to report hot flashes than the nonsmoking carriers (AOR 6.16, 95% CI 1.11–33.91). Conclusion: This is the first report demonstrating the effects of smoking within the strata of gene variants involved in sex steroid metabolism on hot flashes in late reproductive-age women. The identification of individuals with a genetic susceptibility to smoking-related menopausal symptoms could contribute to interventions targeted at reducing reproductive morbidity both in the menopause and across the reproductive life course. PMID:22466345

  14. Cratering and penetration experiments in Teflon targets at velocities from 1 to 7 km/s

    NASA Technical Reports Server (NTRS)

    Hoerz, Friedrich; Bernhard, Ronald P.; Cintala, Mark J.; See, Thomas H.

    1995-01-01

    Approximately 20 sq m of protective thermal blankets, largely composed of Teflon, were retrieved from the Long Duration Exposure Facility (LDEF) after the spacecraft had spent approximately 5.7 years in space. Examination of these blankets revealed that they contained thousands of hypervelocity impact features ranging from micron-sized craters to penetration holes several millimeters in diameter. We conducted impact experiments in an effort to reproduce such features and to -- hopefully -- understand the relationships between projectile size and the resulting crater or penetration-hole diameter over a wide range of impact velocity. Such relationships are needed to derive the size- and mass-frequency distribution and flux of natural and man-made particles in low-Earth orbit. Powder propellant and light-gas guns were used to launch soda-lime glass spheres of 3.175 mm (1/8 inch) nominal diameter (Dp) into pure Teflon FEP targets at velocities ranging from 1 to 7 km/s. Target thickness (T) was varied over more than three orders of magnitude from infinite halfspace targets (Dp/T less than 0.1) to very thin films (Dp/T greater than 100). Cratering and penetration of massive Teflon targets is dominated by brittle failure and the development of extensive spall zones at the target's front and, if penetrated, the target's rear side. Mass removal by spallation at the back side of Teflon targets may be so severe that the absolute penetration-hole diameter (Dh) can become larger than that of a standard crater (Dc) at relative target thicknesses of Dp/T = 0.6-0.9. The crater diameter is infinite halfspace Teflon targets increases -- at otherwise constant impact conditions -- with encounter velocity by a factor of V0.44. In contrast, the penetration-hole size is very thin foils (Dp/T greater than 50) is essentially unaffected by impact velocity. Penetrations at target thicknesses intermediate to these extremes will scale with variable exponents of V. Our experimental matrix is sufficiently systematic and complete, up to 7 km/s, to make reasonable recommendations for the velocity-scaling of Teflon craters and penetrations. We specifically suggest that cratering behavior and associated equations dominate all impacts in which the shock-pulse duration of the projectile (tp) is shorter than that of the target (tt). We also demonstrate that each penetration hole from space-retrieved surfaces may be assigned a unique projectile size, provided an impact velocity is known or assumed. This calibration seems superior to the traditional ballistic-limit approach.

  15. Cratering and penetration experiments in Teflon targets at velocities from 1 to 7 km/s

    NASA Astrophysics Data System (ADS)

    Hoerz, Friedrich; Bernhard, Ronald P.; Cintala, Mark J.; See, Thomas H.

    1995-02-01

    Approximately 20 sq m of protective thermal blankets, largely composed of Teflon, were retrieved from the Long Duration Exposure Facility (LDEF) after the spacecraft had spent approximately 5.7 years in space. Examination of these blankets revealed that they contained thousands of hypervelocity impact features ranging from micron-sized craters to penetration holes several millimeters in diameter. We conducted impact experiments in an effort to reproduce such features and to -- hopefully -- understand the relationships between projectile size and the resulting crater or penetration-hole diameter over a wide range of impact velocity. Such relationships are needed to derive the size- and mass-frequency distribution and flux of natural and man-made particles in low-Earth orbit. Powder propellant and light-gas guns were used to launch soda-lime glass spheres of 3.175 mm (1/8 inch) nominal diameter (Dp) into pure Teflon FEP targets at velocities ranging from 1 to 7 km/s. Target thickness (T) was varied over more than three orders of magnitude from infinite halfspace targets (Dp/T less than 0.1) to very thin films (Dp/T greater than 100). Cratering and penetration of massive Teflon targets is dominated by brittle failure and the development of extensive spall zones at the target's front and, if penetrated, the target's rear side. Mass removal by spallation at the back side of Teflon targets may be so severe that the absolute penetration-hole diameter (Dh) can become larger than that of a standard crater (Dc) at relative target thicknesses of Dp/T = 0.6-0.9. The crater diameter is infinite halfspace Teflon targets increases -- at otherwise constant impact conditions -- with encounter velocity by a factor of V0.44. In contrast, the penetration-hole size is very thin foils (Dp/T greater than 50) is essentially unaffected by impact velocity. Penetrations at target thicknesses intermediate to these extremes will scale with variable exponents of V. Our experimental matrix is sufficiently systematic and complete, up to 7 km/s, to make reasonable recommendations for the velocity-scaling of Teflon craters and penetrations. We specifically suggest that cratering behavior and associated equations dominate all impacts in which the shock-pulse duration of the projectile (tp) is shorter than that of the target (tt). We also demonstrate that each penetration hole from space-retrieved surfaces may be assigned a unique projectile size, provided an impact velocity is known or assumed. This calibration seems superior to the traditional ballistic-limit approach.

  16. A Thick Target for Synchrotrons and Betatrons

    DOE R&D Accomplishments Database

    McMillan, E. M.

    1950-09-19

    If a wide x-ray beam from an electron synchrotron or betatron is desired, in radiographic work with large objects for example, the usually very thin target may be replaced by a thick one, provided the resulting distortion of the x-ray spectrum due to multiple radiative processes is permissible. It is difficult to make the circulating electron beam traverse a thick target directly because of the small spacing between successive turns. Mounting a very thin beryllium, or other low-z material, fin on the edge of the thick target so that the fin projects into the beam will cause the beam to lose sufficient energy, and therefore radium, to strike the thick target the next time around. Sample design calculations are given.

  17. Region based Brain Computer Interface for a home control application.

    PubMed

    Akman Aydin, Eda; Bay, Omer Faruk; Guler, Inan

    2015-08-01

    Environment control is one of the important challenges for disabled people who suffer from neuromuscular diseases. Brain Computer Interface (BCI) provides a communication channel between the human brain and the environment without requiring any muscular activation. The most important expectation for a home control application is high accuracy and reliable control. Region-based paradigm is a stimulus paradigm based on oddball principle and requires selection of a target at two levels. This paper presents an application of region based paradigm for a smart home control application for people with neuromuscular diseases. In this study, a region based stimulus interface containing 49 commands was designed. Five non-disabled subjects were attended to the experiments. Offline analysis results of the experiments yielded 95% accuracy for five flashes. This result showed that region based paradigm can be used to select commands of a smart home control application with high accuracy in the low number of repetitions successfully. Furthermore, a statistically significant difference was not observed between the level accuracies.

  18. Defect Implosion Experiments (DIME) at OMEGA

    NASA Astrophysics Data System (ADS)

    Cobble, J. A.; Schmitt, M. J.; Tregillis, I. L.; Obrey, K. D.; Magelssen, G. R.; Wilke, M. D.; Glebov, V.; Marshall, F. J.; Kim, Y. H.; Bradley, P. A.; Batha, S. H.

    2010-11-01

    The Los Alamos DIME campaign involves perturbed spherical implosions, driven by 60 OMEGA beams with uniform, symmetrical illumination. D-T-filled CH-shell targets with equatorial-plane defects are designed to produce a non-spherical neutron burn region. The objectives of the DIME series are to observe the non-spherical burn with the neutron imaging system (NIS) and to simulate the physics of the neutron and x-ray production. We have demonstrated adequate neutron yield for NIS imaging with targets of diameter 860 μm. All targets are filled with 5 atm of DT. We used two separate shell thicknesses: 8 μm and 15 μm, thus testing both exploding pusher and ablative designs. Defect channel depth ranges from 0 -- 8 μm. Width is 20 -- 40 μm. Perfect targets have no defect. Numerical simulations predict enhanced x-ray emission, that is suggested by experiment. Results from a recent DIME campaign will be discussed.

  19. Dispersion of Projectile and Target Debris Upon Penetration of Thin Targets

    NASA Astrophysics Data System (ADS)

    Gwynn, D.; Bernhard, R. P.; See, T. H.; Horz, F.

    1996-03-01

    We continue to conduct penetration experiments of thin foils to support the development of cosmic-dust flight instruments that utilize thin films for the measurement of particle trajectories, or for the potential soft capture of hypervelocity impactors for subsequent compositional analysis upon retrieval to Earth. Each experiment is equipped with a witness plate, mounted to the rear of the target and fabricated from soft Aluminum-1100, ~30 x 30 cm in size and ranging from 2 to 5 mm thick; these witness plates essentially simulate the rear wall of a capture cell onto which the projectile material will plate out, including material that is being dislodged from the penetrated foil itself. Using compositionally contrasting projectile and foil materials in the laboratory, such as soda-lime glass impactors and aluminum targets, one produces two distinct populations of craters on the witness plates.

  20. Fabrication of aerogel capsule, bromine-doped capsule, and modified gold cone in modified target for the Fast Ignition Realization Experiment (FIREX) Project

    NASA Astrophysics Data System (ADS)

    Nagai, Keiji; Yang, H.; Norimatsu, T.; Azechi, H.; Belkada, F.; Fujimoto, Y.; Fujimura, T.; Fujioka, K.; Fujioka, S.; Homma, H.; Ito, F.; Iwamoto, A.; Jitsuno, T.; Kaneyasu, Y.; Nakai, M.; Nemoto, N.; Saika, H.; Shimoyama, T.; Suzuki, Y.; Yamanaka, K.; Mima, K.

    2009-09-01

    The development of target fabrication for the Fast Ignition Realization EXperiment (FIREX) Project is described in this paper. For the first stage of the FIREX Project (FIREX-I), the previously designed target has been modified by using a bromine-doped ablator and coating the inner gold cone with a low-density material. A high-quality bromine-doped capsule without vacuoles was fabricated from bromine-doped deuterated polystyrene. The gold surface was coated with a low-density material by electrochemical plating. For the cryogenic fuel target, a brand new type of aerogel material, phloroglucinol/formaldehyde (PF), was investigated and encapsulated to meet the specifications of 500 µm diameter and 20 µm thickness, with 30 nm nanopores. Polystyrene-based low-density materials were investigated and the relationship between the crosslinker content and the nanopore structure was observed.

  1. Laboratory study of hyper-elocity impact-driven chemical reactions and surface evolution in icy targets.

    NASA Astrophysics Data System (ADS)

    Ulibarri, Z.; Munsat, T.; Dee, R.; Horanyi, M.; James, D.; Kempf, S.; Nagle, M.; Sternovsky, Z.

    2017-12-01

    Although ice is prevalent in the solar system and the long-term evolution of many airless icy bodies is affected by hypervelocity micrometeoroid bombardment, there has been little experimental investigation into these impact phenomena, especially at the impact speeds encountered in space. For example, there is little direct information about how dust impacts alter the local chemistry, and dust impacts may be an important mechanism for creating complex organic molecules necessary for life. Laser ablation and light-gas gun experiments simulating dust impacts have successfully created amino acid precursors from base components in ice surfaces. Additionally, the Cassini mission revealed CO2 deposits in icy satellites of Saturn, which may have been created by dust impacts. With the creation of a cryogenically cooled ice target for the dust accelerator facility at the NASA SSERVI-funded Institute for Modeling Plasma, Atmospheres, and Cosmic Dust (IMPACT), it is now possible to study the effects of micrometeoroid impacts in a controlled environment under conditions and at energies typically encountered in nature. Complex ice-target mixtures are created with a flash-freezing target which allows for homogeneous mixtures to be frozen in place even with salt mixtures that otherwise would form inhomogeneous ice surfaces. Coupled with the distinctive capabilities of the IMPACT dust facility, highly valuable data concerning the evolution of icy bodies under hypervelocity bombardment and the genesis of complex organic chemistry on these icy bodies can be gathered in unique and tightly controlled experiments. Results from recent and ongoing investigations will be presented.

  2. SU-E-T-489: Incorporating Skin Flash Into VMAT WBI: Impacts On Surface Dosimetry

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Buele, A Bejarano; Tanny, S; Warrell, G

    Purpose: Increased use of inverse planning limits the amount of skin flash in whole breast irradiation (WBI). Strategies to incorporate flash into inverse-planned treatments involve overriding air to the density of water or tissue. This introduces uncertainties to the superficial dose distribution, potentially degrading the coverage at the skin-bolus interface. We investigate the accuracy of various commonly used bolus materials to incorporate flash in VMAT WBI plans while minimizing the perturbation near the skin. Methods: We obtained a CT-simulation of an anthropomorphic phantom with a breast attachment. Three VMAT plans were created with different boluses: 1 cm of 1 g/cm{supmore » 3} bolus (Superflab), 1 cm of 0.65 g/cm{sup 3} bolus (wet towels), and 1 cm of g/cm{sup 3} bolus with 2 dose levels accounting for the difference between bolus and tissue density. The PTV was extended into the bolus, outside the patient body contour to incorporate flash. OSLDs were used to obtain surface doses at the medial, lateral and tip sites of the breast. Each plan was irradiated four times using CBCT for positioning and dosimeter localization. Results: The average thickness of the wet-towel bolus on delivery was 8 mm with a CBCT-measured density of 0.6 g/cm{sup 3}. OSLD measurements demonstrated good agreement with predicted doses from Pinnacle. Average deviations were −5.7%, −2.5%, and −2.6% for plans 1, 2, and 3, respectively. OSLDs placed at the medial and lateral portions of the breast showed the largest average deviations. The maximum recorded deviation from planned values was −8.6%. The largest dose fluctuations occurred near areas where the bolus failed to properly conform to the breast contour. Conclusion: Use of wet-towel bolus improved dose delivery accuracy compared to standard Superflab bolus. Areas of poor bolus conformity adversely affected dose delivery. We recommend the use of wet-towel bolus over Superflab bolus for VMAT WBI.« less

  3. Progress in Fast Ignition Studies with Electrons and Protons

    NASA Astrophysics Data System (ADS)

    MacKinnon, A. J.; Akli, K. U.; Bartal, T.; Beg, F. N.; Chawla, S.; Chen, C. D.; Chen, H.; Chen, S.; Chowdhury, E.; Fedosejevs, R.; Freeman, R. R.; Hey, D.; Higginson, D.; Key, M. H.; King, J. A.; Link, A.; Ma, T.; MacPhee, A. G.; Offermann, D.; Ovchinnikov, V.; Pasley, J.; Patel, P. K.; Ping, Y.; Schumacher, D. W.; Stephens, R. B.; Tsui, Y. Y.; Wei, M. S.; Van Woerkom, L. D.

    2009-09-01

    Isochoric heating of inertially confined fusion plasmas by laser driven MeV electrons or protons is an area of great topical interest in the inertial confinement fusion community, particularly with respect to the fast ignition (FI) concept for initiating burn in a fusion capsule. In order to investigate critical aspects needed for a FI point design, experiments were performed to study 1) laser-to-electrons or protons conversion issues and 2) laser-cone interactions including prepulse effects. A large suite of diagnostics was utilized to study these important parameters. Using cone—wire surrogate targets it is found that pre-pulse levels on medium scale lasers such as Titan at Lawrence Livermore National Laboratory produce long scale length plasmas that strongly effect coupling of the laser to FI relevant electrons inside cones. The cone wall thickness also affects coupling to the wire. Conversion efficiency to protons has also been measured and modeled as a function of target thickness, material. Conclusions from the proton and electron source experiments will be presented. Recent advances in modeling electron transport and innovative target designs for reducing igniter energy and increasing gain curves will also be discussed. In conclusion, a program of study will be presented based on understanding the fundamental physics of the electron or proton source relevant to FI.

  4. High-resolution myocardial T1 mapping using single-shot inversion recovery fast low-angle shot MRI with radial undersampling and iterative reconstruction

    PubMed Central

    Joseph, Arun A; Kalentev, Oleksandr; Merboldt, Klaus-Dietmar; Voit, Dirk; Roeloffs, Volkert B; van Zalk, Maaike; Frahm, Jens

    2016-01-01

    Objective: To develop a novel method for rapid myocardial T1 mapping at high spatial resolution. Methods: The proposed strategy represents a single-shot inversion recovery experiment triggered to early diastole during a brief breath-hold. The measurement combines an adiabatic inversion pulse with a real-time readout by highly undersampled radial FLASH, iterative image reconstruction and T1 fitting with automatic deletion of systolic frames. The method was implemented on a 3-T MRI system using a graphics processing unit-equipped bypass computer for online application. Validations employed a T1 reference phantom including analyses at simulated heart rates from 40 to 100 beats per minute. In vivo applications involved myocardial T1 mapping in short-axis views of healthy young volunteers. Results: At 1-mm in-plane resolution and 6-mm section thickness, the inversion recovery measurement could be shortened to 3 s without compromising T1 quantitation. Phantom studies demonstrated T1 accuracy and high precision for values ranging from 300 to 1500 ms and up to a heart rate of 100 beats per minute. Similar results were obtained in vivo yielding septal T1 values of 1246 ± 24 ms (base), 1256 ± 33 ms (mid-ventricular) and 1288 ± 30 ms (apex), respectively (mean ± standard deviation, n = 6). Conclusion: Diastolic myocardial T1 mapping with use of single-shot inversion recovery FLASH offers high spatial resolution, T1 accuracy and precision, and practical robustness and speed. Advances in knowledge: The proposed method will be beneficial for clinical applications relying on native and post-contrast T1 quantitation. PMID:27759423

  5. Laser irradiation effects on thin aluminum plates subjected to surface flow

    NASA Astrophysics Data System (ADS)

    Jiang, Houman; Zhao, Guomin; Chen, Minsun; Peng, Xin

    2016-10-01

    The irradiation effects of LD laser on thin aluminum alloy plates are studied in experiments characterized by relatively large laser spot and the presence of 0.3Ma surface airflow. A high speed profilometer is used to record the profile change along a vertical line in the rear surface of the target, and the history of the displacement along the direction of thickness of the central point at the rear surface is obtained. The results are compared with those without airflow and those by C. D. Boley. We think that it is the temperature rise difference along the direction of thickness instead of the pressure difference caused by the airflow that makes the thin target bulge into the incoming beam, no matter whether the airflow is blown or not, and that only when the thin aluminum target is heated thus softened enough by the laser irradiation, can the aerodynamic force by the surface airflow cause non-ignorable localized plastic deformation and result a burn-through without melting in the target. However, though the target isn't softened enough in terms of the pressure difference, it might have experienced notable deformation as it is heated from room temperature to several hundred degree centigrade.

  6. Simulations and experiments of ejecta generation in twice-shocked metals

    NASA Astrophysics Data System (ADS)

    Karkhanis, Varad; Ramaprabhu, Praveen; Buttler, William; Hammerberg, James; Cherne, Frank; Andrews, Malcolm

    2016-11-01

    Using continuum hydrodynamics embedded in the FLASH code, we model ejecta generation in recent target experiments, where a metallic surface was loaded by two successive shock waves. The experimental data were obtained from a two-shockwave, high-explosive tool at Los Alamos National Laboratory, capable of generating ejecta from a shocked tin surface in to a vacuum. In both simulations and experiment, linear growth is observed following the first shock event, while the second shock strikes a finite-amplitude interface leading to nonlinear growth. The timing of the second incident shock was varied systematically in our simulations to realize a finite-amplitude re-initialization of the RM instability driving the ejecta. We find the shape of the interface at the event of second shock is critical in determining the amount of ejecta, and thus must be used as an initial condition to evaluate subsequent ejected mass using a source model. In particular, the agreement between simulations, experiments and the mass model is improved when shape effects associated with the interface at second shock are incorporated. This work was supported in part by the (U.S.) Department of Energy (DOE) under Contract No. DE-AC52-06NA2-5396.

  7. Experiments To Demonstrate Chemical Process Safety Principles.

    ERIC Educational Resources Information Center

    Dorathy, Brian D.; Mooers, Jamisue A.; Warren, Matthew M.; Mich, Jennifer L.; Murhammer, David W.

    2001-01-01

    Points out the need to educate undergraduate chemical engineering students on chemical process safety and introduces the content of a chemical process safety course offered at the University of Iowa. Presents laboratory experiments demonstrating flammability limits, flash points, electrostatic, runaway reactions, explosions, and relief design.…

  8. Ensemble: a web-based system for psychology survey and experiment management.

    PubMed

    Tomic, Stefan T; Janata, Petr

    2007-08-01

    We provide a description of Ensemble, a suite of Web-integrated modules for managing and analyzing data associated with psychology experiments in a small research lab. The system delivers interfaces via a Web browser for creating and presenting simple surveys without the need to author Web pages and with little or no programming effort. The surveys may be extended by selecting and presenting auditory and/or visual stimuli with MATLAB and Flash to enable a wide range of psychophysical and cognitive experiments which do not require the recording of precise reaction times. Additionally, one is provided with the ability to administer and present experiments remotely. The software technologies employed by the various modules of Ensemble are MySQL, PHP, MATLAB, and Flash. The code for Ensemble is open source and available to the public, so that its functions can be readily extended by users. We describe the architecture of the system, the functionality of each module, and provide basic examples of the interfaces.

  9. Point Cloud Based Relative Pose Estimation of a Satellite in Close Range

    PubMed Central

    Liu, Lujiang; Zhao, Gaopeng; Bo, Yuming

    2016-01-01

    Determination of the relative pose of satellites is essential in space rendezvous operations and on-orbit servicing missions. The key problems are the adoption of suitable sensor on board of a chaser and efficient techniques for pose estimation. This paper aims to estimate the pose of a target satellite in close range on the basis of its known model by using point cloud data generated by a flash LIDAR sensor. A novel model based pose estimation method is proposed; it includes a fast and reliable pose initial acquisition method based on global optimal searching by processing the dense point cloud data directly, and a pose tracking method based on Iterative Closest Point algorithm. Also, a simulation system is presented in this paper in order to evaluate the performance of the sensor and generate simulated sensor point cloud data. It also provides truth pose of the test target so that the pose estimation error can be quantified. To investigate the effectiveness of the proposed approach and achievable pose accuracy, numerical simulation experiments are performed; results demonstrate algorithm capability of operating with point cloud directly and large pose variations. Also, a field testing experiment is conducted and results show that the proposed method is effective. PMID:27271633

  10. Spatial interpolation of GPS PWV and meteorological variables over the west coast of Peninsular Malaysia during 2013 Klang Valley Flash Flood

    NASA Astrophysics Data System (ADS)

    Suparta, Wayan; Rahman, Rosnani

    2016-02-01

    Global Positioning System (GPS) receivers are widely installed throughout the Peninsular Malaysia, but the implementation for monitoring weather hazard system such as flash flood is still not optimal. To increase the benefit for meteorological applications, the GPS system should be installed in collocation with meteorological sensors so the precipitable water vapor (PWV) can be measured. The distribution of PWV is a key element to the Earth's climate for quantitative precipitation improvement as well as flash flood forecasts. The accuracy of this parameter depends on a large extent on the number of GPS receiver installations and meteorological sensors in the targeted area. Due to cost constraints, a spatial interpolation method is proposed to address these issues. In this paper, we investigated spatial distribution of GPS PWV and meteorological variables (surface temperature, relative humidity, and rainfall) by using thin plate spline (tps) and ordinary kriging (Krig) interpolation techniques over the Klang Valley in Peninsular Malaysia (longitude: 99.5°-102.5°E and latitude: 2.0°-6.5°N). Three flash flood cases in September, October, and December 2013 were studied. The analysis was performed using mean absolute error (MAE), root mean square error (RMSE), and coefficient of determination (R2) to determine the accuracy and reliability of the interpolation techniques. Results at different phases (pre, onset, and post) that were evaluated showed that tps interpolation technique is more accurate, reliable, and highly correlated in estimating GPS PWV and relative humidity, whereas Krig is more reliable for predicting temperature and rainfall during pre-flash flood events. During the onset of flash flood events, both methods showed good interpolation in estimating all meteorological parameters with high accuracy and reliability. The finding suggests that the proposed method of spatial interpolation techniques are capable of handling limited data sources with high accuracy, which in turn can be used to predict future floods.

  11. Proceedings of the Workshop on the Chemical Suppression of Rocket Afterburning and of Gun Muzzle Flash

    DTIC Science & Technology

    1987-03-01

    We report here the first results of this gun simulator used in the study of muzzle flash. The test setup used is shown in Figure 18. Pressure ports...experiments. For the first tests , the exploding wires mentioned above ignited the gas mixture. Later, "soft" ignition by means of a single tungsten...wire, placed axially in the chamber, was also tested . The voltage pulse applied across this hot wire is shown in Figure 19. This "soft" ignition

  12. Large-scale uniform bilayer graphene prepared by vacuum graphitization of 6H-SiC(0001) substrates

    NASA Astrophysics Data System (ADS)

    Wang, Qingyan; Zhang, Wenhao; Wang, Lili; He, Ke; Ma, Xucun; Xue, Qikun

    2013-03-01

    We report on the preparation of large-scale uniform bilayer graphenes on nominally flat Si-polar 6H-SiC(0001) substrates by flash annealing in ultrahigh vacuum. The resulting graphenes have a single thickness of one bilayer and consist of regular terraces separated by the triple SiC bilayer steps on the 6H-SiC(0001) substrates. In situ scanning tunneling microscopy reveals that suppression of pit formation on terraces and uniformity of SiC decomposition at step edges are the key factors to the uniform thickness. By studying the surface morphologies prepared under different annealing rates, it is found that the annealing rate is directly related to SiC decomposition, diffusion of the released Si/C atoms and strain relaxation, which together determine the final step structure and density of defects.

  13. Large-scale uniform bilayer graphene prepared by vacuum graphitization of 6H-SiC(0001) substrates.

    PubMed

    Wang, Qingyan; Zhang, Wenhao; Wang, Lili; He, Ke; Ma, Xucun; Xue, Qikun

    2013-03-06

    We report on the preparation of large-scale uniform bilayer graphenes on nominally flat Si-polar 6H-SiC(0001) substrates by flash annealing in ultrahigh vacuum. The resulting graphenes have a single thickness of one bilayer and consist of regular terraces separated by the triple SiC bilayer steps on the 6H-SiC(0001) substrates. In situ scanning tunneling microscopy reveals that suppression of pit formation on terraces and uniformity of SiC decomposition at step edges are the key factors to the uniform thickness. By studying the surface morphologies prepared under different annealing rates, it is found that the annealing rate is directly related to SiC decomposition, diffusion of the released Si/C atoms and strain relaxation, which together determine the final step structure and density of defects.

  14. Torsion Induced Traumatic Optic Neuropathy (TITON): Animal Model for Diagnostics, Drugs Delivery, and Therapeutics for Injuries to the Cental Nervous System

    DTIC Science & Technology

    2016-06-01

    neck and the eye coils are actively decoupled. The following parameters will be used: slice thickness = 1 mm, TR = 4 s, TE = 13 ms, label duration... Eyes were removed with 3-5 mm of optic nerve intact taking care not to stretch or otherwise injure the nerve. Eyes were flash frozen in liquid...nitrogen, then stored at -80°C. The eyes were then sectioned through the optic nerve using a cryostat, then transferred to indium titanium oxide-coated

  15. Results of operating LIA-2 in radiograph mode

    NASA Astrophysics Data System (ADS)

    Starostenko, D. A.; Logachev, P. V.; Akimov, A. V.; Korepanov, A. A.; Bak, P. A.; Panov, A. N.; Pachkov, A. A.; Eliseev, A. A.; Ottmar, A. V.; Kulenko, Ya. V.; Bolkhovityanov, D. Yu.; Fatkin, G. A.; Pavlov, O. A.; Kuznetsov, G. I.; Nikolaev, I. V.; Batazova, M. A.; Batrakov, A. M.; Boimelshtein, Yu. M.; Pavlenko, A. V.

    2014-09-01

    The LIA-2 linear induction accelerator was developed at the Budker Institute of Nuclear Physics as an electron beam injector for a building induction accelerator at energy of 20 MeV, on the basis of which a complex for flash radiography will be developed. The LIA-2, which was started up in 2010, is currently used as an independent X-ray unit for raying objects with an optic thickness up to 70 mm in the lead equivalent. The effective diameter of the X-ray source is 0.6-0.7 mm.

  16. Two-photon coincident emission from thick targets for 70-keV incident electrons

    NASA Astrophysics Data System (ADS)

    Liu, J.; Kahler, D. L.; Quarles, C. A.

    1993-04-01

    Two-photon coincidence yields have been measured in thick targets of C, Al, Ag, and Ta for 70 keV incident electrons and photons radiated at +/-45° to the incident beam. A theoretical model, which is more rigorous, has been developed to simulate the two-photon processes of coherent thick-target double bremsstrahlung (TTDB) and the incoherent emission of two single-bremsstrahlung (SBSB) photons in a thick-target environment. The model is based on an integration of the thin-target cross sections over the target thickness taking into account electron energy loss, electron backscattering, and photon attenuation. It predicts a yield that is much lower than that of the previous model. The prediction of the model fits the present experimental data well by adjusting the relative weight of the two competing processes, and we find that TTDB dominates at low Z and incoherent SBSB dominates at higher Z.

  17. Synchronization to auditory and visual rhythms in hearing and deaf individuals

    PubMed Central

    Iversen, John R.; Patel, Aniruddh D.; Nicodemus, Brenda; Emmorey, Karen

    2014-01-01

    A striking asymmetry in human sensorimotor processing is that humans synchronize movements to rhythmic sound with far greater precision than to temporally equivalent visual stimuli (e.g., to an auditory vs. a flashing visual metronome). Traditionally, this finding is thought to reflect a fundamental difference in auditory vs. visual processing, i.e., superior temporal processing by the auditory system and/or privileged coupling between the auditory and motor systems. It is unclear whether this asymmetry is an inevitable consequence of brain organization or whether it can be modified (or even eliminated) by stimulus characteristics or by experience. With respect to stimulus characteristics, we found that a moving, colliding visual stimulus (a silent image of a bouncing ball with a distinct collision point on the floor) was able to drive synchronization nearly as accurately as sound in hearing participants. To study the role of experience, we compared synchronization to flashing metronomes in hearing and profoundly deaf individuals. Deaf individuals performed better than hearing individuals when synchronizing with visual flashes, suggesting that cross-modal plasticity enhances the ability to synchronize with temporally discrete visual stimuli. Furthermore, when deaf (but not hearing) individuals synchronized with the bouncing ball, their tapping patterns suggest that visual timing may access higher-order beat perception mechanisms for deaf individuals. These results indicate that the auditory advantage in rhythmic synchronization is more experience- and stimulus-dependent than has been previously reported. PMID:25460395

  18. Neutron Skyshine Considerations For The NIF Shielding Design

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Singh, M S; Mecozzi, J M; Tobin, M T

    2004-01-28

    A series of coupled neutron-photon transport Monte-Carlo calculations was performed to estimate the roof shielding required to limit the skyshine dose to less than 1 mrem/y at the site boundary when conducting DT experiments with annual fusion yields up to 1200 MJ (4.2E20 neutrons/y). The NIF shielding design consists of many different components. The basic components include 10-cm-thick Al chamber with 40-cm-thick target chamber gunite shield having multiple penetrations, 1.83-m-thick concrete Target Bay walls, 1.37-m-thick concrete roof, and multiple concrete floors with numerous penetrations. Under this shielding configuration, the skyshine dose at the nearest site-boundary was calculated to be lessmore » than 0.2 mrem/y for all possible target illumination configurations. The potential dose at the site boundary would be about one-tenth of the cosmic neutron dose that we measured with bubble neutron detectors on board a commercial roundtrip flight from SF to Rochester. This incremental dose increase is well within the normal fluctuations (noise) of the natural background radiation in the Livermore area. The skyshine dose has no impact on the public. The skyshine dose trends at ground and elevated levels are plotted as a function of distance from 20 m to 1000 m from the center of the target bay. The differential neutron and photon energy flux emerging from the NIF roof and at several locations on the ground is plotted to show how it shifts with distance. The results of this study are compared with the neutron skyshine studies done at high-energy accelerators by R. H. Thomas.« less

  19. A multi-layered active target for the study of neutron-unbound nuclides at NSCL

    NASA Astrophysics Data System (ADS)

    Freeman, Jessica; Gueye, Paul; Redpath, Thomas; MoNA Collaboration

    2017-01-01

    The characteristics of neutron-unbound nuclides were investigated using a multi-layered Si/Be active target designed for use with the MoNA/LISA setup at the National Superconducting Cyclotron (NSCL). The setup consists of the MoNA/LISA arrays (for neutron detection) and a superconducting sweeper magnet (for charged separation) to identify products following the decay of neutron unbound states. The segmented target consisted of three 700 mg/cm2 beryllium targets and four 0.14 mm thick 62x62 mm2 silicon detectors. As a commissioning experiment for the target the decay of two-neutron unbound 26O populated in a one-proton removal reaction from a radioactive 27F beam was performed. The 27F secondary radioactive beam from the NSCL's Coupled Cyclotron Facility was produced from the fragmentation of a 140 MeV/u 48Ca beam incident on a thick beryllium target and then cleanly selected by the A1900 fragment separator. The energy loss and position spectra of the incoming beam and reaction products were used to calibrate the Silicon detectors to within 1.5% in both energy and position. A dedicated Geant4 model of the target was developed to simulate the energy loss within the target. A description of the experimental setup, simulation work, and energy and position calibration will be presented. DoE/NNSA - DE-NA0000979.

  20. Influence of micromachined targets on laser accelerated proton beam profiles

    NASA Astrophysics Data System (ADS)

    Dalui, Malay; Permogorov, Alexander; Pahl, Hannes; Persson, Anders; Wahlström, Claes-Göran

    2018-03-01

    High intensity laser-driven proton acceleration from micromachined targets is studied experimentally in the target-normal-sheath-acceleration regime. Conical pits are created on the front surface of flat aluminium foils of initial thickness 12.5 and 3 μm using series of low energy pulses (0.5-2.5 μJ). Proton acceleration from such micromachined targets is compared with flat foils of equivalent thickness at a laser intensity of 7 × 1019 W cm-2. The maximum proton energy obtained from targets machined from 12.5 μm thick foils is found to be slightly lower than that of flat foils of equivalent remaining thickness, and the angular divergence of the proton beam is observed to increase as the depth of the pit approaches the foil thickness. Targets machined from 3 μm thick foils, on the other hand, show evidence of increasing the maximum proton energy when the depths of the structures are small. Furthermore, shallow pits on 3 μm thick foils are found to be efficient in reducing the proton beam divergence by a factor of up to three compared to that obtained from flat foils, while maintaining the maximum proton energy.

  1. Why Flash Type Matters: A Statistical Analysis

    NASA Astrophysics Data System (ADS)

    Mecikalski, Retha M.; Bitzer, Phillip M.; Carey, Lawrence D.

    2017-09-01

    While the majority of research only differentiates between intracloud (IC) and cloud-to-ground (CG) flashes, there exists a third flash type, known as hybrid flashes. These flashes have extensive IC components as well as return strokes to ground but are misclassified as CG flashes in current flash type analyses due to the presence of a return stroke. In an effort to show that IC, CG, and hybrid flashes should be separately classified, the two-sample Kolmogorov-Smirnov (KS) test was applied to the flash sizes, flash initiation, and flash propagation altitudes for each of the three flash types. The KS test statistically showed that IC, CG, and hybrid flashes do not have the same parent distributions and thus should be separately classified. Separate classification of hybrid flashes will lead to improved lightning-related research, because unambiguously classified hybrid flashes occur on the same order of magnitude as CG flashes for multicellular storms.

  2. Semantic Categorization Precedes Affective Evaluation of Visual Scenes

    ERIC Educational Resources Information Center

    Nummenmaa, Lauri; Hyona, Jukka; Calvo, Manuel G.

    2010-01-01

    We compared the primacy of affective versus semantic categorization by using forced-choice saccadic and manual response tasks. Participants viewed paired emotional and neutral scenes involving humans or animals flashed rapidly in extrafoveal vision. Participants were instructed to categorize the targets by saccading toward the location occupied by…

  3. Lag and light-transfer characteristics of amorphous selenium photoconductive film with tellurium-doped layer

    NASA Astrophysics Data System (ADS)

    Park, Wug-Dong; Tanioka, Kenkichi

    2016-07-01

    Amorphous selenium (a-Se) high-gain avalanche rushing amorphous photoconductor (HARP) films have been used for highly sensitive imaging devices. To study a-Se HARP films for a solid-state image sensor, current-voltage, lag, spectral response, and light-transfer characteristics of 0.4-µm-thick a-Se HARP films are investigated. Also, to clarify a suitable Te-doped a-Se layer thickness in the a-Se photoconductor, we considered the effects of Te-doped layer thickness on the lag, spectral response, and light-transfer characteristics of 0.4-µm-thick a-Se HARP films. The threshold field, at which avalanche multiplication occurs in the a-Se HARP targets, decreases when the Te-doped layer thickness increases. The lag of 0.4-µm-thick a-Se HARP targets with Te-doped layers is higher than that of the target without Te doping. The lag of the targets with Te-doped layers is caused by the electrons trapped in the Te-doped layers within the 0.4-µm-thick a-Se HARP films. From the results of the spectral response measurement of about 15 min, the 0.4-µm-thick a-Se HARP targets with Te-doped layers of 90 and 120 nm are observed to be unstable owing to the electrons trapped in the Te-doped a-Se layer. From the light-transfer characteristics of 0.4-µm-thick a-Se HARP targets, as the slope at the operating point of signal current-voltage characteristics in the avalanche mode increases, the γ of the a-Se HARP targets decreases. Considering the effects of dark current on the lag and spectral response characteristics, a Te-doped layer of 60 nm is suitable for 0.4-µm-thick a-Se HARP films.

  4. Experimental constraints on phreatic eruption processes at Whakaari (White Island volcano)

    NASA Astrophysics Data System (ADS)

    Mayer, Klaus; Scheu, Bettina; Gilg, H. Albert; Heap, Michael J.; Kennedy, Ben M.; Lavallée, Yan; Letham-Brake, Mark; Dingwell, Donald B.

    2015-09-01

    Vigorous hydrothermal activity interspersed by sequences of phreatic and phreatomagmatic eruptions occur at Whakaari (White Island volcano), New Zealand. Here, we investigate the influence of sample type (hydrothermally altered cemented ash tuffs and unconsolidated ash/lapilli) and fragmentation mechanism (steam flashing versus gas expansion) on fragmentation and ejection velocities as well as on particle-size and shape. Our rapid decompression experiments show that fragmentation and ejection speeds of two ash tuffs, cemented by alunite and amorphous opal, increase with increasing porosity and that both are significantly enhanced in the presence of steam flashing. Ejection speeds of unconsolidated samples are higher than ejection speeds of cemented tuffs, as less energy is consumed by fragmentation. Fragmentation dominated by steam flashing results in increased fragmentation energy and a higher proportion of fine particles. Particle shape analyses before and after fragmentation reveal that both steam flashing and pure gas expansion produce platy or bladed particles from fracturing parallel to the decompression front. Neither fragmentation mechanisms nor sample type show a significant influence on the shape. Our results emphasize that, under identical pressure and temperature conditions, eruptions accompanied by the process of liquid water flashing to steam are significantly more violent than those driven simply by gas expansion. Therefore, phase changes during decompression and cementation are both important considerations for hazard assessment and modeling of eruptions in hydrothermally active environments.

  5. A novel scattering switch-on detection technique for target-induced plasmon-coupling based sensing by single-particle optical anisotropy imaging.

    PubMed

    Peng, Lan; Cao, Xuan; Xiong, Bin; He, Yan; Yeung, Edward S

    2016-06-18

    We reported a novel scattering switch-on detection technique using flash-lamp polarization darkfield microscopy (FLPDM) for target-induced plasmon-coupling based sensing in homogeneous solution. With this method, we demonstrated sub-nM sensitivity for hydrogen sulfide (H2S) detection over a dynamic range of five orders of magnitude. This robust technique holds great promise for applications in toxic environmental pollutants and biological molecules.

  6. Development of cable fed flash X-ray (FXR) system

    NASA Astrophysics Data System (ADS)

    Menon, Rakhee; Mitra, S.; Patel, A. S.; Kumar, R.; Singh, G.; Senthil, K.; Kumar, Ranjeet; Kolge, T. S.; Roy, Amitava; Acharya, S.; Biswas, D.; Sharma, Archana

    2017-08-01

    Flash X-ray sources driven by pulsed power find applications in industrial radiography, and a portable X-ray source is ideal where the radiography needs to be taken at the test site. A compact and portable flash X-ray (FXR) system based on a Marx generator has been developed with the high voltage fed to the FXR tube via a cable feed-through arrangement. Hard bremsstrahlung X-rays of few tens of nanosecond duration are generated by impinging intense electron beams on an anode target of high Z material. An industrial X-ray source is developed with source size as low as 1 mm. The system can be operated from 150 kV to 450 kV peak voltages and a dose of 10 mR has been measured at 1 m distance from the source window. The modeling of the FXR source has been carried out using particle-in-cell and Monte Carlo simulations for the electron beam dynamics and X-ray generation, respectively. The angular dose profile of X-ray has been measured and compared with the simulation.

  7. Generation and dose distribution measurement of flash x-ray in KALI-5000 system

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Menon, Rakhee; Roy, Amitava; Mitra, S.

    2008-10-15

    Flash x-ray generation studies have been carried out in KALI-5000 Pulse power system. The intense relativistic electron beam has been bombarded on a tantalum target at anode to produce flash x-ray via bremsstrahlung conversion. The typical electron beam parameter was 360 kV, 18 kA, and 100 ns, with a few hundreds of A/cm{sup 2} current density. The x-ray dose has been measured with calcium sulfate:dysposium (CaSO{sub 4}:Dy) thermoluminescent dosimeter and the axial dose distribution has been characterized. It has been observed that the on axis dose falls of with distance {approx}1/x{sup n}, where n varies from 1.8 to 1.85. Amore » maximum on axis dose of 46 mrad has been measured at 1 m distance from the source. A plastic scintillator with optical fiber coupled to a photomultiplier tube has been developed to measure the x-ray pulse width. The typical x-ray pulse width varied from 50 to 80 ns.« less

  8. On the feasibility to perform integral transmission experiments in the GELINA target hall at IRMM

    NASA Astrophysics Data System (ADS)

    Leconte, Pierre; Jean, Cyrille De Saint; Geslot, Benoit; Plompen, Arjan; Belloni, Francesca; Nyman, Markus

    2017-09-01

    Shielding experiments are relevant to validate elastic and inelastic scattering cross sections in the fast energy range. In this paper, we are focusing on the possibility to use the pulsed white neutron time-of-flight facility GELINA to perform this kind of measurement. Several issues need to be addressed: neutron source intensity, room return effect, distance of the materials to be irradiated from the source, and the sensitivity of various reaction rate distributions through the material to different input cross sections. MCNP6 and TRIPOLI4 calculations of the outgoing neutron spectrum are compared, based on electron/positron/gamma/neutron simulations. A first guess of an integral transmission experiment through a 238U slab is considered. It shows that a 10 cm thickness of uranium is sufficient to reach a high sensitivity to the 238U inelastic scattering cross section in the [2-5 MeV] energy range, with small contributions from elastic and fission cross sections. This experiment would contribute to reduce the uncertainty on this nuclear data, which has a significant impact on the power distribution in large commercial reactors. Other materials that would be relevant for the ASTRID 4th generation prototype reactor are also tested, showing that a sufficient sensitivity to nuclear data would be obtained by using a 50 to 100cm thick slab of side 60x60cm. This study concludes on the feasibility and interest of such experiments in the target hall of the GELINA facility.

  9. In-flight radiographic study of two nonaxisymmetric, explosively formed penetrators

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Schwalbe, L.A.; Mueller, K.H. Jr.; Christian, J.M.

    1988-03-01

    We present in-flight radiographic images of two explosively formed penetrators (EFPs) of tantalum. The data were obtained with Ecto, a flash x-ray source that delivers a single, 50-ns pulse of radiation with an effective mean energy of 1.4)pulse))minus) 0.1 MeV. The enrgy and flux of the beam are sufficient to penetrate the EFPs and reveal their internal structure. The subjects of this study are two warheads of an identical nonaxisymmetric design. One warhead was fired in each of two separate experiments. The warheads were oriented perpendicular to one another to provide separate orthogonal views of their EFPs. The radiographs weremore » then digitized and subjected to several numerical analyses, which include estimates of the masses of the EFPs, their center-of-mass coordinates, and plots of the attenuation lengths (or material thicknesses) at various positions. Optical photographs were also taken of the front and profile of one EFP. The optical data aid in interpretating the radioagraphy by allowing identification of the visible external features. 3 refs., 16 figs.« less

  10. Generation of monoenergetic ion beams via ionization dynamics (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Lin, Chen; Kim, I. Jong; Yu, Jinqing; Choi, Il Woo; Ma, Wenjun; Yan, Xueqing; Nam, Chang Hee

    2017-05-01

    The research on ion acceleration driven by high intensity laser pulse has attracted significant interests in recent decades due to the developments of laser technology. The intensive study of energetic ion bunches is particularly stimulated by wide applications in nuclear fusion, medical treatment, warm dense matter production and high energy density physics. However, to implement such compact accelerators, challenges are still existing in terms of beam quality and stability, especially in applications that require higher energy and narrow bandwidth spectra ion beams. We report on the acceleration of quasi-mono-energetic ion beams via ionization dynamics in the interaction of an intense laser pulse with a solid target. Using ionization dynamics model in 2D particle-in-cell (PIC) simulations, we found that high charge state contamination ions can only be ionized in the central spot area where the intensity of sheath field surpasses their ionization threshold. These ions automatically form a microstructure target with a width of few micron scale, which is conducive to generate mono-energetic beams. In the experiment of ultraintense (< 10^21 W/cm^2) laser pulses irradiating ultrathin targets each attracted with a contamination layer of nm-thickness, high quality < 100 MeV mono-energetic ion bunches are generated. The peak energy of the self-generated micro-structured target ions with respect to different contamination layer thickness is also examined This is relatively newfound respect, which is confirmed by the consistence between experiment data and the simulation results.

  11. Human Visuospatial Updating After Passive Translations In Three-Dimensional Space

    PubMed Central

    Klier, Eliana M.; Hess, Bernhard J. M.; Angelaki, Dora E.

    2013-01-01

    To maintain a stable representation of the visual environment as we move, the brain must update the locations of targets in space using extra-retinal signals. Humans can accurately update after intervening active whole-body translations. But can they also update for passive translations (i.e., without efference copy signals of an outgoing motor command)? We asked six head-fixed subjects to remember the location of a briefly flashed target (five possible targets were located at depths of 23, 33, 43, 63 and 150cm in front of the cyclopean eye) as they moved 10cm left, right, up, down, forward or backward, while fixating a head-fixed target at 53cm. After the movement, the subjects made a saccade to the remembered location of the flash with a combination of version and vergence eye movements. We computed an updating ratio where 0 indicates no updating and 1 indicates perfect updating. For lateral and vertical whole-body motion, where updating performance is judged by the size of the version movement, the updating ratios were similar for leftward and rightward translations, averaging 0.84±0.28 (mean±SD), as compared to 0.51±0.33 for downward and 1.05±0.50 for upward translations. For forward/backward movements, where updating performance is judged by the size of the vergence movement, the average updating ratio was 1.12±0.45. Updating ratios tended to be larger for far targets than near targets, although both intra- and inter-subject variabilities were smallest for near targets. Thus, in addition to self-generated movements, extra-retinal signals involving otolith and proprioceptive cues can also be used for spatial constancy. PMID:18256164

  12. Cultivation of Scenedesmus obliquus in liquid hydrolysate from flash hydrolysis for nutrient recycling

    PubMed Central

    Barbera, Elena; Sforza, Eleonora; Kumar, Sandeep; Morosinotto, Tomas; Bertucco, Alberto

    2016-01-01

    The production of biofuels from microalgae is associated with high demands of nutrients (nitrogen and phosphorus) required for growth. Recycling nutrients from the residual biomass is essential to obtain a sustainable production. In this work, the aqueous phase obtained from flash hydrolysis of Scenedesmus sp. was used as cultivation medium for a microalga of the same genus, to assess the feasibility of this technique for nutrient recycling purposes. Batch and continuous cultivations were carried out, to determine growth performances in this substrate compared to standard media, and verify if a stable biomass production could be obtained. In continuous experiments, the effect of hydrolysate inlet concentration and of residence time were assessed to optimize nutrient supply in relation to productivity. Results obtained show that nutrient recycling is feasible by treating biomass with flash hydrolysis, and Scenedesmus is capable of recycling large amounts of recovered nutrients. PMID:26868157

  13. Simultaneous operation of two soft x-ray free-electron lasers driven by one linear accelerator

    NASA Astrophysics Data System (ADS)

    Faatz, B.; Plönjes, E.; Ackermann, S.; Agababyan, A.; Asgekar, V.; Ayvazyan, V.; Baark, S.; Baboi, N.; Balandin, V.; von Bargen, N.; Bican, Y.; Bilani, O.; Bödewadt, J.; Böhnert, M.; Böspflug, R.; Bonfigt, S.; Bolz, H.; Borges, F.; Borkenhagen, O.; Brachmanski, M.; Braune, M.; Brinkmann, A.; Brovko, O.; Bruns, T.; Castro, P.; Chen, J.; Czwalinna, M. K.; Damker, H.; Decking, W.; Degenhardt, M.; Delfs, A.; Delfs, T.; Deng, H.; Dressel, M.; Duhme, H.-T.; Düsterer, S.; Eckoldt, H.; Eislage, A.; Felber, M.; Feldhaus, J.; Gessler, P.; Gibau, M.; Golubeva, N.; Golz, T.; Gonschior, J.; Grebentsov, A.; Grecki, M.; Grün, C.; Grunewald, S.; Hacker, K.; Hänisch, L.; Hage, A.; Hans, T.; Hass, E.; Hauberg, A.; Hensler, O.; Hesse, M.; Heuck, K.; Hidvegi, A.; Holz, M.; Honkavaara, K.; Höppner, H.; Ignatenko, A.; Jäger, J.; Jastrow, U.; Kammering, R.; Karstensen, S.; Kaukher, A.; Kay, H.; Keil, B.; Klose, K.; Kocharyan, V.; Köpke, M.; Körfer, M.; Kook, W.; Krause, B.; Krebs, O.; Kreis, S.; Krivan, F.; Kuhlmann, J.; Kuhlmann, M.; Kube, G.; Laarmann, T.; Lechner, C.; Lederer, S.; Leuschner, A.; Liebertz, D.; Liebing, J.; Liedtke, A.; Lilje, L.; Limberg, T.; Lipka, D.; Liu, B.; Lorbeer, B.; Ludwig, K.; Mahn, H.; Marinkovic, G.; Martens, C.; Marutzky, F.; Maslocv, M.; Meissner, D.; Mildner, N.; Miltchev, V.; Molnar, S.; Mross, D.; Müller, F.; Neumann, R.; Neumann, P.; Nölle, D.; Obier, F.; Pelzer, M.; Peters, H.-B.; Petersen, K.; Petrosyan, A.; Petrosyan, G.; Petrosyan, L.; Petrosyan, V.; Petrov, A.; Pfeiffer, S.; Piotrowski, A.; Pisarov, Z.; Plath, T.; Pototzki, P.; Prandolini, M. J.; Prenting, J.; Priebe, G.; Racky, B.; Ramm, T.; Rehlich, K.; Riedel, R.; Roggli, M.; Röhling, M.; Rönsch-Schulenburg, J.; Rossbach, J.; Rybnikov, V.; Schäfer, J.; Schaffran, J.; Schlarb, H.; Schlesselmann, G.; Schlösser, M.; Schmid, P.; Schmidt, C.; Schmidt-Föhre, F.; Schmitz, M.; Schneidmiller, E.; Schöps, A.; Scholz, M.; Schreiber, S.; Schütt, K.; Schütz, U.; Schulte-Schrepping, H.; Schulz, M.; Shabunov, A.; Smirnov, P.; Sombrowski, E.; Sorokin, A.; Sparr, B.; Spengler, J.; Staack, M.; Stadler, M.; Stechmann, C.; Steffen, B.; Stojanovic, N.; Sychev, V.; Syresin, E.; Tanikawa, T.; Tavella, F.; Tesch, N.; Tiedtke, K.; Tischer, M.; Treusch, R.; Tripathi, S.; Vagin, P.; Vetrov, P.; Vilcins, S.; Vogt, M.; de Zubiaurre Wagner, A.; Wamsat, T.; Weddig, H.; Weichert, G.; Weigelt, H.; Wentowski, N.; Wiebers, C.; Wilksen, T.; Willner, A.; Wittenburg, K.; Wohlenberg, T.; Wortmann, J.; Wurth, W.; Yurkov, M.; Zagorodnov, I.; Zemella, J.

    2016-06-01

    Extreme-ultraviolet to x-ray free-electron lasers (FELs) in operation for scientific applications are up to now single-user facilities. While most FELs generate around 100 photon pulses per second, FLASH at DESY can deliver almost two orders of magnitude more pulses in this time span due to its superconducting accelerator technology. This makes the facility a prime candidate to realize the next step in FELs—dividing the electron pulse trains into several FEL lines and delivering photon pulses to several users at the same time. Hence, FLASH has been extended with a second undulator line and self-amplified spontaneous emission (SASE) is demonstrated in both FELs simultaneously. FLASH can now deliver MHz pulse trains to two user experiments in parallel with individually selected photon beam characteristics. First results of the capabilities of this extension are shown with emphasis on independent variation of wavelength, repetition rate, and photon pulse length.

  14. Emotion-induced impairments in speeded word recognition tasks.

    PubMed

    Zeelenberg, René; Bocanegra, Bruno R; Pecher, Diane

    2011-01-01

    Recent studies show that emotional stimuli impair the identification of subsequently presented, briefly flashed stimuli. In the present study, we investigated whether emotional distractors (primes) impaired target processing when presentation of the target stimulus was not impoverished. In lexical decision, animacy decision, rhyme decision, and nonword naming, targets were presented in such a manner that they were clearly visible (i.e., targets were not masked and presented until participants responded). In all tasks taboo-sexual distractors caused a slowdown in responding to the subsequent neutral target. Our results indicate that the detrimental effects of emotional distractors are not confined to paradigms in which visibility of the target is limited. Moreover, impairments were obtained even when semantic processing of stimuli was not required.

  15. Investigation of Hypervelocity Impact Phenomena Using Real-Time Concurrent Diagnostics

    NASA Astrophysics Data System (ADS)

    Mihaly, Jonathan Michael

    Hypervelocity impact of meteoroids and orbital debris poses a serious and growing threat to spacecraft. To study hypervelocity impact phenomena, a comprehensive ensemble of real-time concurrently operated diagnostics has been developed and implemented in the Small Particle Hypervelocity Impact Range (SPHIR) facility. This suite of simultaneously operated instrumentation provides multiple complementary measurements that facilitate the characterization of many impact phenomena in a single experiment. The investigation of hypervelocity impact phenomena described in this work focuses on normal impacts of 1.8 mm nylon 6/6 cylinder projectiles and variable thickness aluminum targets. The SPHIR facility two-stage light-gas gun is capable of routinely launching 5.5 mg nylon impactors to speeds of 5 to 7 km/s. Refinement of legacy SPHIR operation procedures and the investigation of first-stage pressure have improved the velocity performance of the facility, resulting in an increase in average impact velocity of at least 0.57 km/s. Results for the perforation area indicate the considered range of target thicknesses represent multiple regimes describing the non-monotonic scaling of target perforation with decreasing target thickness. The laser side-lighting (LSL) system has been developed to provide ultra-high-speed shadowgraph images of the impact event. This novel optical technique is demonstrated to characterize the propagation velocity and two-dimensional optical density of impact-generated debris clouds. Additionally, a debris capture system is located behind the target during every experiment to provide complementary information regarding the trajectory distribution and penetration depth of individual debris particles. The utilization of a coherent, collimated illumination source in the LSL system facilitates the simultaneous measurement of impact phenomena with near-IR and UV-vis spectrograph systems. Comparison of LSL images to concurrent IR results indicates two distinctly different phenomena. A high-speed, pressure-dependent IR-emitting cloud is observed in experiments to expand at velocities much higher than the debris and ejecta phenomena observed using the LSL system. In double-plate target configurations, this phenomena is observed to interact with the rear-wall several micro-seconds before the subsequent arrival of the debris cloud. Additionally, dimensional analysis presented by Whitham for blast waves is shown to describe the pressure-dependent radial expansion of the observed IR-emitting phenomena. Although this work focuses on a single hypervelocity impact configuration, the diagnostic capabilities and techniques described can be used with a wide variety of impactors, materials, and geometries to investigate any number of engineering and scientific problems.

  16. Measurement of g Using a Flashing LED

    NASA Astrophysics Data System (ADS)

    Terzella, T.; Sundermier, J.; Sinacore, J.; Owen, C.; Takai, H.

    2008-10-01

    In one of the classic free-fall experiments, a small mass is attached to a strip of paper tape and both are allowed to fall through a spark timer, where sparks are generated at regular time intervals. Students analyze marks (dots) left on the tape by the timer, thereby generating distance-versus-time data, which they analyze to extract the acceleration due to gravity g with good results. The apparatus, however, is cumbersome and often frustrating for students. High-tech versions of this experiment are done with an object dropped and followed by a motion sensor connected to a computer. The sensor relies on ultrasonic ranging to record distance and time data, which may then be displayed graphically. Students inspect the graphs to determine the value of g. Although the results are excellent, the emphasis on the computer's ability to collect and analyze data leaves little analysis for the students to perform.2 Furthermore, neither technique gives an intuitive display of what is happening. The motivation for our work was to overcome these issues by developing an innovative method for measuring g. In our version of the experiment, students drop a flashing LED at a known frequency and record its trajectory using long exposure photography with a digital camera. Proper choice of flashing LED timing parameters produces an image that allows for an accurate measurement of g and at the same time helps to explain what happens during free fall. The experiment remains high-tech in the sense that students learn to use updated equipment to record data and to carry out the analysis.

  17. Hypervelocity impacts into ice-topped layered targets: Investigating the effects of ice crust thickness and subsurface density on crater morphology

    NASA Astrophysics Data System (ADS)

    Harriss, Kathryn H.; Burchell, Mark J.

    2017-07-01

    Many bodies in the outer solar system are theorized to have an ice shell with a different subsurface material below, be it chondritic, regolith, or a subsurface ocean. This layering can have a significant influence on the morphology of impact craters. Accordingly, we have undertaken laboratory hypervelocity impact experiments on a range of multilayered targets, with interiors of water, sand, and basalt. Impact experiments were undertaken using impact speeds in the range of 0.8-5.3 km s-1, a 1.5 mm Al ball bearing projectile, and an impact incidence of 45°. The surface ice crust had a thickness between 5 and 50 mm, i.e., some 3-30 times the projectile diameter. The thickness of the ice crust as well as the nature of the subsurface layer (liquid, well consolidated, etc.) have a marked effect on the morphology of the resulting impact crater, with thicker ice producing a larger crater diameter (at a given impact velocity), and the crater diameter scaling with impact speed to the power 0.72 for semi-infinite ice, but with 0.37 for thin ice. The density of the subsurface material changes the structure of the crater, with flat crater floors if there is a dense, well-consolidated subsurface layer (basalt) or steep, narrow craters if there is a less cohesive subsurface (sand). The associated faulting in the ice surface is also dependent on ice thickness and the substrate material. We find that the ice layer (in impacts at 5 km s-1) is effectively semi-infinite if its thickness is more than 15.5 times the projectile diameter. Below this, the crater diameter is reduced by 4% for each reduction in ice layer thickness equal to the impactor diameter. Crater depth is also affected. In the ice thickness region, 7-15.5 times the projectile diameter, the crater shape in the ice is modified even when the subsurface layer is not penetrated. For ice thicknesses, <7 times the projectile diameter, the ice layer is breached, but the nature of the resulting crater depends heavily on the subsurface material. If the subsurface is noncohesive (loose) material, a crater forms in it. If it is dense, well-consolidated basalt, no crater forms in the exposed subsurface layer.

  18. Exterior Rigid Foam Insulation at the Edge of a Slab Foundation, Fresno, California (Fact Sheet)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    Exterior rigid foam insulation at the edge of the slab foundation was a unique feature for this low-load, unoccupied test house in a hot-dry climate and may be more appropriate for climates with higher heating loads. U.S. Department of Energy Building America research team IBACOS worked with National Housing Quality Award winner Wathen-Castanos Hybrid Homes, Inc., to assess the performance of this feature in a single-family detached ranch house with three bedrooms and two full bathrooms constructed on a slab-on-grade foundation in Fresno, California. One challenge during installation of the system was the attachment of the butyl flashing to themore » open framing. To solve this constructability issue, the team added a nailer to the base of the wall to properly attach and lap the flashing. In this strategy, R-7.5, 1.5-in.-thick extruded polystyrene was installed on the exterior of the slab for a modeled savings of 4,500 Btu/h on the heating load.« less

  19. New Whole-House Solutions Case Study: Exterior Rigid Foam Insulation at the Edge of a Slab Foundation, Fresno, California

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    Exterior rigid foam insulation at the edge of the slab foundation was a unique feature for this low-load, unoccupied test house in a hot-dry climate and may be more appropriate for climates with higher heating loads. U.S. Department of Energy Building America research team IBACOS worked with National Housing Quality Award winner Wathen-Castanos Hybrid Homes, Inc., to assess the performance of this feature in a single-family detached ranch house with three bedrooms and two full bathrooms constructed on a slab-on-grade foundation in Fresno, California. One challenge during installation of the system was the attachment of the butyl flashing to themore » open framing. To solve this constructability issue, the team added a nailer to the base of the wall to properly attach and lap the flashing. In this strategy, R-7.5, 1.5-in.-thick extruded polystyrene was installed on the exterior of the slab for a modeled savings of 4,500 Btu/h on the heating load.« less

  20. Turbulent spots and scalar flashes in pipe transition

    NASA Astrophysics Data System (ADS)

    Adrian, Ronald; Wu, Xiaohua; Moin, Parviz

    2017-11-01

    Recent study (Wu et al., PNAS, 1509451112, 2015) demonstrated the feasibility and accuracy of direct computation of the Osborne Reynolds' pipe transition experiment without the unphysical axially periodic boundary condition. Here we use this approach to address three questions: (1) What are the dynamics of turbulent spot generation in pipe transition? (2) How is the succession of scalar flashes, as observed and sketched by Osborne Reynolds, created? (3) What happens to the succession of flashes further downstream? In this study, the inlet disturbance is of radial-mode type imposed through a narrow, three-degree numerical wedge; and the simulation Reynolds number is 6500. Numerical dye is introduced at the inlet plane locally very close to the pipe axis, similar to the needle injection by O. Reynolds. Inception of infant turbulent spots occurs when normal, forward inclined hairpin packets form near the walls from the debris of the inlet perturbations. However, the young and mature turbulent spots consist almost exclusively of reverse, backward leaning hairpin vortices. Scalar flashes appear successively downstream and persist well into the fully-developed turbulent region. Their creation mechanism is addressed. RJA gratefully acknowledges support of the National Science Foundation with NSF Award CBET-0933848.

  1. Sounds can boost the awareness of visual events through attention without cross-modal integration.

    PubMed

    Pápai, Márta Szabina; Soto-Faraco, Salvador

    2017-01-31

    Cross-modal interactions can lead to enhancement of visual perception, even for visual events below awareness. However, the underlying mechanism is still unclear. Can purely bottom-up cross-modal integration break through the threshold of awareness? We used a binocular rivalry paradigm to measure perceptual switches after brief flashes or sounds which, sometimes, co-occurred. When flashes at the suppressed eye coincided with sounds, perceptual switches occurred the earliest. Yet, contrary to the hypothesis of cross-modal integration, this facilitation never surpassed the assumption of probability summation of independent sensory signals. A follow-up experiment replicated the same pattern of results using silent gaps embedded in continuous noise, instead of sounds. This manipulation should weaken putative sound-flash integration, although keep them salient as bottom-up attention cues. Additional results showed that spatial congruency between flashes and sounds did not determine the effectiveness of cross-modal facilitation, which was again not better than probability summation. Thus, the present findings fail to fully support the hypothesis of bottom-up cross-modal integration, above and beyond the independent contribution of two transient signals, as an account for cross-modal enhancement of visual events below level of awareness.

  2. Pilot plant test of the advanced flash stripper for CO2 capture.

    PubMed

    Lin, Yu-Jeng; Chen, Eric; Rochelle, Gary T

    2016-10-20

    Alternative stripping processes have been proposed to reduce energy use for CO 2 capture, but only a few have been applied to pilot-scale experiments. This paper presents the first pilot plant test results of one of the most promising stripper configurations, the advanced flash stripper with cold and warm rich solvent bypass. The campaign using aqueous piperazine was carried out at UT Austin in 2015. The advanced flash stripper improves the heat duty by over 25% compared to previous campaigns using the two-stage flash, achieving 2.1 GJ per tonne CO 2 of heat duty and 32 kJ mol -1 CO 2 of total equivalent work. The bypass control strategy proposed minimized the heat duty. The test successfully demonstrated the remarkable energy performance and the operability of this advanced system. An Aspen Plus® model was validated using the pilot plant data and used to explore optimum operating and design conditions. The irreversibility analysis showed that the pilot plant performance has attained 50% thermodynamic efficiency and further energy improvement should focus on the absorber and the cross exchanger by increasing absorption rate and solvent capacity.

  3. Characterization of Thermal Stability and High-Temperature Tribological Behavior of Electroless Ni-B Coating

    NASA Astrophysics Data System (ADS)

    Pal, Soupitak; Sarkar, Rohit; Jayaram, Vikram

    2018-05-01

    A preliminary study has been conducted using sequences of isothermal heat treatments and unidirectional high-temperature wear test following ball-on-flat geometry against an alumina counterface, to assess thermal stability and high-temperature tribological properties of the crystalline electroless Ni-B coating, a potential candidate for high-temperature solid lubricant coating. Isothermal heat treatment of 450 °C/15 h causes a significant amount of B diffusion into the Fe substrate without altering the coating's through-thickness hardness and nanostructure. At room temperature, a very low wear rate is observed, which increases up to two orders of magnitude above a testing temperature of 100 °C. Room-temperature wear behavior is mostly governed by oxidative wear, where friction-induced heating produces a thick oxide scale on the wear track, which subsequently decreases the wear rate by preventing direct contact between the coating and counterface. In the case of wear tests above 100 °C, removal of the same oxide layer occurs through local plastic deformation, essentially plastic ratcheting at the contacting region by flow softening of the contacting surface layer due to a local rise in temperature. Worn track morphology shows similarity with the severe wear seen in steel-steel contacts. Experimental observations have been explained and validated using the concept of contact point flash temperature. A quantitative assessment of contact point flash temperature has been carried out adopting the methodology, proposed by Ashby et al. The effects of applied normal load, test geometry, choice of counterface material, and testing temperatures on the transition of wear mechanism are critically discussed.

  4. Diode magnetic-field influence on radiographic spot size

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ekdahl, Carl A. Jr.

    2012-09-04

    Flash radiography of hydrodynamic experiments driven by high explosives is a well-known diagnostic technique in use at many laboratories. The Dual-Axis Radiography for Hydrodynamic Testing (DARHT) facility at Los Alamos was developed for flash radiography of large hydrodynamic experiments. Two linear induction accelerators (LIAs) produce the bremsstrahlung radiographic source spots for orthogonal views of each experiment ('hydrotest'). The 2-kA, 20-MeV Axis-I LIA creates a single 60-ns radiography pulse. For time resolution of the hydrotest dynamics, the 1.7-kA, 16.5-MeV Axis-II LIA creates up to four radiography pulses by slicing them out of a longer pulse that has a 1.6-{micro}s flattop. Bothmore » axes now routinely produce radiographic source spot sizes having full-width at half-maximum (FWHM) less than 1 mm. To further improve on the radiographic resolution, one must consider the major factors influencing the spot size: (1) Beam convergence at the final focus; (2) Beam emittance; (3) Beam canonical angular momentum; (4) Beam-motion blur; and (5) Beam-target interactions. Beam emittance growth and motion in the accelerators have been addressed by careful tuning. Defocusing by beam-target interactions has been minimized through tuning of the final focus solenoid for optimum convergence and other means. Finally, the beam canonical angular momentum is minimized by using a 'shielded source' of electrons. An ideal shielded source creates the beam in a region where the axial magnetic field is zero, thus the canonical momentum zero, since the beam is born with no mechanical angular momentum. It then follows from Busch's conservation theorem that the canonical angular momentum is minimized at the target, at least in principal. In the DARHT accelerators, the axial magnetic field at the cathode is minmized by using a 'bucking coil' solenoid with reverse polarity to cancel out whatever solenoidal beam transport field exists there. This is imperfect in practice, because of radial variation of the total field across the cathode surface, solenoid misalignments, and long-term variability of solenoid fields for given currents. Therefore, it is useful to quantify the relative importance of canonical momentum in determining the focal spot, and to establish a systematic methodology for tuning the bucking coils for minimum spot size. That is the purpose of this article. Section II provides a theoretical foundation for understanding the relative importance of the canonical momentum. Section III describes the results of simulations used to quantify beam parameters, including the momentum, for each of the accelerators. Section IV compares the two accelerators, especially with respect to mis-tuned bucking coils. Finally, Section IV concludes with a methodology for optimizing the bucking coil settings.« less

  5. Measurement And Calculation of High-Energy Neutron Spectra Behind Shielding at the CERF 120-GeV/C Hadron Beam Facility

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nakao, N.; /SLAC; Taniguchi, S.

    Neutron energy spectra were measured behind the lateral shield of the CERF (CERN-EU High Energy Reference Field) facility at CERN with a 120 GeV/c positive hadron beam (a mixture of mainly protons and pions) on a cylindrical copper target (7-cm diameter by 50-cm long). An NE213 organic liquid scintillator (12.7-cm diameter by 12.7-cm long) was located at various longitudinal positions behind shields of 80- and 160-cm thick concrete and 40-cm thick iron. The measurement locations cover an angular range with respect to the beam axis between 13 and 133{sup o}. Neutron energy spectra in the energy range between 32 MeVmore » and 380 MeV were obtained by unfolding the measured pulse height spectra with the detector response functions which have been verified in the neutron energy range up to 380 MeV in separate experiments. Since the source term and experimental geometry in this experiment are well characterized and simple and results are given in the form of energy spectra, these experimental results are very useful as benchmark data to check the accuracies of simulation codes and nuclear data. Monte Carlo simulations of the experimental set up were performed with the FLUKA, MARS and PHITS codes. Simulated spectra for the 80-cm thick concrete often agree within the experimental uncertainties. On the other hand, for the 160-cm thick concrete and iron shield differences are generally larger than the experimental uncertainties, yet within a factor of 2. Based on source term simulations, observed discrepancies among simulations of spectra outside the shield can be partially explained by differences in the high-energy hadron production in the copper target.« less

  6. Narrow Energy Spread Protons and Ions from High-Intensity, High-Contrast Laser Solid Target Interactions

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dollar, Franklin; Matsuoka, Takeshi; McGuffey, Christopher

    2010-11-04

    Recent simulations show that an idealized, high intensity, short pulse laser can generate quasi-monoenergetic proton beams with energies over 100 MeV in an interaction with a thin film. However, most short pulse laser facilities with sufficient intensity have difficulty controlling the nanosecond and picosecond contrast necessary to realize such a regime. Experiments were performed to investigate proton and ion acceleration from a high contrast, short pulse laser by employing dual plasma mirrors along with a deformable mirror at the HERCULES laser facility at the Center for Ultrafast Optical Sciences, University of Michigan. Plasma mirrors were characterized, allowing a 50% throughputmore » with an intensity contrast increase of 105. The focal spot quality was also exceptional, showing a 1.1 micron full width at half maximum (FWHM) focal diameter. Experiments were done using temporally cleaned 30 TW, 32 fs pulses to achieve an intensity of up to 10{sup 21} Wcm{sup -2} on Si{sub 3}N{sub 4} and Mylar targets with thicknesses ranging 50 nm to 13 microns. Proton beams with energy spreads below 2 MeV were observed from all thicknesses, peaking with energies up to 10.3 MeV and an energy spread of 0.8 MeV. Similar narrow energy spreads were observed for oxygen, nitrogen, and carbon at the silicon nitride thickness of 50 nm with energies up to 24 MeV with an energy spread of 3 MeV, whereas the energy spread is greatly increased at a larger thickness. Maximum energies were confirmed with CR39 track detectors, while a Thomson ion spectrometer was used to gauge the monoenergetic nature of the beam.« less

  7. Dissociable contribution of the parietal and frontal cortex to coding movement direction and amplitude

    PubMed Central

    Davare, Marco; Zénon, Alexandre; Desmurget, Michel; Olivier, Etienne

    2015-01-01

    To reach for an object, we must convert its spatial location into an appropriate motor command, merging movement direction and amplitude. In humans, it has been suggested that this visuo-motor transformation occurs in a dorsomedial parieto-frontal pathway, although the causal contribution of the areas constituting the “reaching circuit” remains unknown. Here we used transcranial magnetic stimulation (TMS) in healthy volunteers to disrupt the function of either the medial intraparietal area (mIPS) or dorsal premotor cortex (PMd), in each hemisphere. The task consisted in performing step-tracking movements with the right wrist towards targets located in different directions and eccentricities; targets were either visible for the whole trial (Target-ON) or flashed for 200 ms (Target-OFF). Left and right mIPS disruption led to errors in the initial direction of movements performed towards contralateral targets. These errors were corrected online in the Target-ON condition but when the target was flashed for 200 ms, mIPS TMS manifested as a larger endpoint spreading. In contrast, left PMd virtual lesions led to higher acceleration and velocity peaks—two parameters typically used to probe the planned movement amplitude—irrespective of the target position, hemifield and presentation condition; in the Target-OFF condition, left PMd TMS induced overshooting and increased the endpoint dispersion along the axis of the target direction. These results indicate that left PMd intervenes in coding amplitude during movement preparation. The critical TMS timings leading to errors in direction and amplitude were different, namely 160–100 ms before movement onset for mIPS and 100–40 ms for left PMd. TMS applied over right PMd had no significant effect. These results demonstrate that, during motor preparation, direction and amplitude of goal-directed movements are processed by different cortical areas, at distinct timings, and according to a specific hemispheric organization. PMID:25999837

  8. Enhanced Laser-Driven Ion Acceleration by Superponderomotive Electrons Generated from Near-Critical-Density Plasma

    NASA Astrophysics Data System (ADS)

    Bin, J. H.; Yeung, M.; Gong, Z.; Wang, H. Y.; Kreuzer, C.; Zhou, M. L.; Streeter, M. J. V.; Foster, P. S.; Cousens, S.; Dromey, B.; Meyer-ter-Vehn, J.; Zepf, M.; Schreiber, J.

    2018-02-01

    We report on the experimental studies of laser driven ion acceleration from a double-layer target where a near-critical density target with a few-micron thickness is coated in front of a nanometer-thin diamondlike carbon foil. A significant enhancement of proton maximum energies from 12 to ˜30 MeV is observed when a relativistic laser pulse impinges on the double-layer target under linear polarization. We attributed the enhanced acceleration to superponderomotive electrons that were simultaneously measured in the experiments with energies far beyond the free-electron ponderomotive limit. Our interpretation is supported by two-dimensional simulation results.

  9. White light velocity interferometer

    DOEpatents

    Erskine, D.J.

    1999-06-08

    The invention is a technique that allows the use of broadband and incoherent illumination. Although denoted white light velocimetry, this principle can be applied to any wave phenomenon. For the first time, powerful, compact or inexpensive sources can be used for remote target velocimetry. These include flash and arc lamps, light from detonations, pulsed lasers, chirped frequency lasers, and lasers operating simultaneously in several wavelengths. The technique is demonstrated with white light from an incandescent source to measure a target moving at 16 m/s. 41 figs.

  10. White light velocity interferometer

    DOEpatents

    Erskine, David J.

    1997-01-01

    The invention is a technique that allows the use of broadband and incoherent illumination. Although denoted white light velocimetry, this principle can be applied to any wave phenomenon. For the first time, powerful, compact or inexpensive sources can be used for remote target velocimetry. These include flash and arc lamps, light from detonations, pulsed lasers, chirped frequency lasers, and lasers operating simultaneously in several wavelengths. The technique is demonstrated with white light from an incandescent source to measure a target moving at 16 m/s.

  11. White light velocity interferometer

    DOEpatents

    Erskine, David J.

    1999-01-01

    The invention is a technique that allows the use of broadband and incoherent illumination. Although denoted white light velocimetry, this principle can be applied to any wave phenomenon. For the first time, powerful, compact or inexpensive sources can be used for remote target velocimetry. These include flash and arc lamps, light from detonations, pulsed lasers, chirped frequency lasers, and lasers operating simultaneously in several wavelengths. The technique is demonstrated with white light from an incandescent source to measure a target moving at 16 m/s.

  12. White light velocity interferometer

    DOEpatents

    Erskine, D.J.

    1997-06-24

    The invention is a technique that allows the use of broadband and incoherent illumination. Although denoted white light velocimetry, this principle can be applied to any wave phenomenon. For the first time, powerful, compact or inexpensive sources can be used for remote target velocimetry. These include flash and arc lamps, light from detonations, pulsed lasers, chirped frequency lasers, and lasers operating simultaneously in several wavelengths. The technique is demonstrated with white light from an incandescent source to measure a target moving at 16 m/s. 41 figs.

  13. Numerical modelling of impact crater formation associated with isolated lunar skylight candidates on lava tubes

    NASA Astrophysics Data System (ADS)

    Martellato, E.; Foing, B. H.; Benkhoff, J.

    2013-09-01

    Skylights are openings on subsurface voids as lava tubes and caves. Recently deep hole structures, possibly skylights, were discovered on lunar photo images by the JAXA SELenological and ENgineering Explorer (SELENE)-Kaguya mission, and successively confirmed by the NASA Lunar Reconnaissance Orbiter (LRO) mission. Vertical hole structures and possibly underlying subsurface voids have high potential as resources for scientific study, and future unmanned and manned activities on the Moon. One mechanism proposed for their formation is impact cratering. The collapse of craters is due to the back spallation phenomena on the rear surface of the lava tube roofs. Previous analysis in this topic was based on small-scales laboratory experiments. These have pointed out that (i) the target thickness-to-crater diameter ratio is 0.7, and (ii) the projectile diameter-to-target thickness ratio is 0.16, at the ballistic limit once extrapolated to planetary conditions.

  14. Production of 92Y via the 92Zr(n,p) reaction using the C(d,n) accelerator neutron source

    NASA Astrophysics Data System (ADS)

    Kin, Tadahiro; Sanzen, Yukimasa; Kamida, Masaki; Watanabe, Yukinobu; Itoh, Masatoshi

    2017-09-01

    We have proposed a new method of producing medical radioisotope 92Y as a candidate of alternatives of 111In bioscan prior to 90Y ibritumomab tiuxetan treatment. The 92Y isotope is produced via the 92Zr (n,p) reaction using accelerator neutrons generated by the interaction of deuteron beams with carbon. A feasibility experiment was performed at Cyclotron and Radioisotope Center, Tohoku University. A carbon thick target was irradiated by 20-MeV deuterons to produce accelerator neutrons. The thick target neutron yield (TTNY) was measured by using the multiple foils activation method. The foils were made of Al, Fe, Co, Ni, Zn, Zr, Nb, and Au. The production amount of 92Y and induced impurities were estimated by simulation with the measured TTNY and the JENDL-4.0 nuclear data.

  15. Comparison of the BCI Performance between the Semitransparent Face Pattern and the Traditional Face Pattern.

    PubMed

    Cheng, Jiao; Jin, Jing; Wang, Xingyu

    2017-01-01

    Brain-computer interface (BCI) systems allow users to communicate with the external world by recognizing the brain activity without the assistance of the peripheral motor nervous system. P300-based BCI is one of the most common used BCI systems that can obtain high classification accuracy and information transfer rate (ITR). Face stimuli can result in large event-related potentials and improve the performance of P300-based BCI. However, previous studies on face stimuli focused mainly on the effect of various face types (i.e., face expression, face familiarity, and multifaces) on the BCI performance. Studies on the influence of face transparency differences are scarce. Therefore, we investigated the effect of semitransparent face pattern (STF-P) (the subject could see the target character when the stimuli were flashed) and traditional face pattern (F-P) (the subject could not see the target character when the stimuli were flashed) on the BCI performance from the transparency perspective. Results showed that STF-P obtained significantly higher classification accuracy and ITR than those of F-P ( p < 0.05).

  16. Applicability of a Bonner Shere technique for pulsed neutron in 120 GeV proton facility

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sanami, T.; Hagiwara, M.; Iwase, H.

    2008-02-01

    The data on neutron spectra and intensity behind shielding are important for radiation safety design of high-energy accelerators since neutrons are capable of penetrating thick shielding and activating materials. Corresponding particle transport codes--that involve physics models of neutron and other particle production, transportation, and interaction--have been developed and used world-wide [1-8]. The results of these codes have been ensured through plenty of comparisons with experimental results taken in simple geometries. For neutron generation and transport, several related experiments have been performed to measure neutron spectra, attenuation length and reaction rates behind shielding walls of various thicknesses and materials in energymore » range up to several hundred of MeV [9-11]. The data have been used to benchmark--and modify if needed--the simulation modes and parameters in the codes, as well as the reference data for radiation safety design. To obtain such kind of data above several hundred of MeV, Japan-Fermi National Accelerator Laboratory (FNAL) collaboration for shielding experiments has been started in 2007, based on suggestion from the specialist meeting of shielding, Shielding Aspects of Target, Irradiation Facilities (SATIF), because of very limited data available in high-energy region (see, for example, [12]). As a part of this shielding experiment, a set of Bonner sphere (BS) was tested at the antiproton production target facility (pbar target station) at FNAL to obtain neutron spectra induced by a 120-GeV proton beam in concrete and iron shielding. Generally, utilization of an active detector around high-energy accelerators requires an improvement on its readout to overcome burst of secondary radiation since the accelerator delivers an intense beam to a target in a short period after relatively long acceleration period. In this paper, we employ BS for a spectrum measurement of neutrons that penetrate the shielding wall of the pbar target station in FNAL.« less

  17. Sleep Characteristics and Carotid Atherosclerosis Among Midlife Women.

    PubMed

    Thurston, Rebecca C; Chang, Yuefang; von Känel, Roland; Barinas-Mitchell, Emma; Jennings, J Richard; Hall, Martica H; Santoro, Nanette; Buysse, Daniel J; Matthews, Karen A

    2017-02-01

    Midlife, which encompasses the menopause transition in women, can be a time of disrupted sleep and accelerated atherosclerosis accumulation. Short or poor sleep quality has been associated with cardiovascular disease (CVD) risk; few studies have investigated relations among midlife women. We tested whether shorter actigraphy sleep time or poorer subjective sleep quality was associated with carotid atherosclerosis among midlife women. Two hundred fifty-six peri- and postmenopausal women aged 40-60 years completed 3 days of wrist actigraphy, hot flash monitoring, questionnaires (Pittsburgh Sleep Quality Index [PSQI], Berlin), a blood draw, and carotid ultrasound [intima media thickness (IMT), plaque]. Associations of objective (actigraphy) and subjective (PSQI) sleep with IMT/plaque were tested in regression models (covariates: age, race, education, body mass index, blood pressure, lipids, insulin resistance, medications, snoring, depressive symptoms, sleep hot flashes, and estradiol). Shorter objective sleep time was associated with higher odds of carotid plaque (for each hour shorter sleep, plaque score ≥ 2, odds ratio (OR) [95% confidence interval, CI] = 1.58 [1.11-2.27], p = .01; plaque score = 1, OR [95% CI] = 0.95 [0.68-1.32], p = .75, vs. no plaque, multivariable). Poorer subjective sleep quality was associated with higher mean IMT [β, b (standard error, SE) = 0.004 (0.002), p = .03], maximal IMT [b (SE) = 0.009 (0.003), p = .005], and plaque [plaque score ≥ 2, OR (95% CI) = 1.23 (1.09-1.40), p = .001; score = 1, OR (95% CI) = 1.06 (0.93-1.21), p = .37, vs. no plaque] in multivariable models. Findings persisted additionally adjusting for sleep hot flashes and estradiol. Shorter actigraphy-assessed sleep time and poorer subjective sleep quality were associated with increased carotid atherosclerosis among midlife women. Associations persisted adjusting for CVD risk factors, hot flashes, and estradiol. © Sleep Research Society 2016. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.

  18. A line-imaging velocity interferometer technique for shock diagnostics without x-ray preheat limitation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wang Feng; Peng Xiaoshi; Liu Shenye

    2011-10-15

    A study was conducted with a line-imaging velocity interferometer on sandwich targets at the Shen Guang-III prototype laser facility in China, with the goal of eliminating the preheat effect. A sandwich target structure was used to reduce the x-ray preheat limitation (radiation temperature {approx}170 eV) in a radiative drive shock experiment. With a thick ablator, the preheat effect appeared before the shock arrived at the window. After adding a shield layer of high-Z material on the ablator, x-rays which penetrated the ablator were so weak that the blank-out effect could not be measured. This experiment indicates that the sandwich targetmore » may provide a valuable technique in experiments such as equation of state and shock timing for inertial confinement fusion studies.« less

  19. Human visual response to nuclear particle exposures

    NASA Technical Reports Server (NTRS)

    Tobias, C. A.; Budinger, T. F.; Lyman, J. T.

    1972-01-01

    Experiments with accelerated helium ions were performed in an effort to localize the site of initial radiation interactions in the eye that lead to light flash observations by astronauts during spaceflight. The character and efficiency of helium ion induction of visual sensations depended on the state of dark adaptation of the retina; also, the same events were seen with different efficiencies and details when particle flux density changed. It was concluded that fast particles cause interactions in the retina, particularly in the receptor layer, and thus give rise to the sensations of light flashes, streaks, and supernovae.

  20. Role of target thickness in proton acceleration from near-critical mass-limited plasmas

    NASA Astrophysics Data System (ADS)

    Kuri, Deep Kumar; Das, Nilakshi; Patel, Kartik

    2017-07-01

    The role played by the target thickness in generating high energetic protons by a circularly polarized laser from near-critical mass-limited targets (MLT) has been investigated with the help of three-dimensional (3D) particle-in-cell (PIC) simulations. The radiation pressure accelerates protons from the front side of the target. Due to hole boring, the target front side gets deformed resulting in a change in the effective angle of incidence which causes vacuum heating and hence generates hot electrons. These hot electrons travel through the target at an angle with the laser axis and hence get more diverged along transverse directions for large target thickness. The hot electrons form sheath fields on the target rear side which accelerates protons via target normal sheath acceleration (TNSA). It is observed that the collimation of radiation pressure accelerated protons gets degraded on reaching the target rear side due to TNSA. The effect of transverse hot electron recirculations gets suppressed and the energetic protons get highly collimated on decreasing target thickness as the radiation pressure acceleration (RPA) starts dominating the acceleration process.

  1. Plume Image Profiling of UV Laser Desorbed Biomolecules

    NASA Astrophysics Data System (ADS)

    Merrigan, T. L.; Hunniford, C. A.; Timson, D. J.; Catney, M.; McCullough, R. W.

    2008-12-01

    An experimental system, based upon the techniques of UV and IR laser desorption with time of flight mass spectrometry, has been constructed to enable the production and characterization of neutral biomolecular targets. The feasibility of the laser desorption technique for the purpose of radiation interaction experiments is investigated here. Fluorescent dye tagging and laser induced fluorescence imaging has been used to help characterize the laser produced plumes of biomolecules revealing their spatial density profiles and temporal evolution. Peak target thicknesses of 2×1012 molecules cm-2 were obtained 30 μs after laser desorption.

  2. Optimizing soft X-ray NEXAFS spectroscopy in the laboratory

    NASA Astrophysics Data System (ADS)

    Mantouvalou, I.; Jonas, A.; Witte, K.; Jung, R.; Stiel, H.; Kanngießer, B.

    2017-05-01

    Near edge X-ray absorption fine structure (NEXAFS) spectroscopy in the soft X-ray range is feasible in the laboratory using laser-produced plasma sources. We present a study using seven different target materials for optimized data analysis. The emission spectra of the materials with atomic numbers ranging from Z = 6 to Z = 79 show distinct differences, rendering the adapted selection of a suitable target material for specialized experiments feasible. For NEXAFS spectroscopy a 112.5 nm thick polyimide film is investigated as a reference exemplifying the superiority of quasi-continuum like emission spectra.

  3. Experimental determination of drag coefficients in low-density polyurethane foam

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Adams, M L

    2006-04-18

    We describe several experiments performed at the LLNL Site 300 firing range and on the LLNL 1/3 scale gun to investigate the deceleration of small projectiles (l {approx} 3-5 [mm]) in low-density foam ({rho} {approx} 0.08-0.32 [g/cm{sup 3}]). The experiments at the firing range researched a passive velocity diagnostic based on Faraday's law of induction, while experiments on the 1/3 scale gun investigated the effects of varying projectile surface area, projectile shape, and foam density on the drag coefficient c{sub d}. Analysis shows that the velocity diagnostic has an uncertainty on the order of 1 percent for projectiles with velocitymore » v {approx} 0.8-1.2 [km/s]. The 1/3 scale gun experiments, dubbed the Krispy Kreme series, included nine shots considering the combinations of 3 projectile surface areas with 3 target densities. The experiments used Tantalum square surface area block projectiles (with an initial velocity v{sub 0} {approx} 1.2 [km/s], a common thickness T = 2.67 [mm], and square side lengths of 3, 4, and 5 [mm]) decelerating in polyurethane foams (with densities {rho}{sub f} of 0.08, 0.16 and 0.32 [g/cm{sup 3}]). Standard fluid models of the Krispy Kreme experiments predict Reynolds numbers Re {approx} 10{sup 5} - 10{sup 6}, Mach numbers Ma {approx} 0.5-2.0, and drag coefficients c{sub d} {approx} 2-3. However, the data indicate that c{sub d} = 1.1-1.2 (c{sub d} = 1.7) for all three block projectiles in the 0.08 and 0.16 [g/cm{sup 3}] targets (0.32 [g/cm{sup 3}] target). First, we conclude that the drag force on projectiles in solid polyurethane foam is less than in fluids with equivalent dimensionless parameters. This result is also supported by an additional Krispy Kreme experiment that used a disk projectile (with diameter d = 4.51 [mm] and thickness T = 2.67 [mm]) penetrating a target with density {rho} = 0.16 [g/cm{sup 3}], i.e., the fluid-like c{sub d} = 1.15 while the measured c{sub d} = 0.63. Second, we conclude that the measured drag coefficient in the lower density foam targets is less than in the larger density foam target. This result is corroborated by firing range experiments with M855 NATO bullets (with diameter 5.56 [mm], mass 4.1 [g], and initial velocity {nu}{sub 0} {approx} 800 [m/s]) fired from an M16 rifle, i.e., c{sub d} = 0.3 (c{sub d} = 0.6) in the 0.16 [g/cm{sup 3}] (0.32 [g/cm{sup 3}]) target. We propose future 1/3 scale gun experiments using a passive velocity diagnostic with increased spatial resolution as well as simple spherical projectiles with 0.5 and 1.0 [cm] diameters.« less

  4. [The optimization of chondromalacia patellae diagnosis by NMR tomography. The use of an apparatus for cartilage compression].

    PubMed

    König, H; Dinkelaker, F; Wolf, K J

    1991-08-01

    The aim of this study was to improve the MRI diagnosis of CMP, with special reference to the early stages and accurate staging. For this purpose, the retropatellar cartilage was examined by MRI while compression was carried out, using 21 patients and five normal controls. The compression was applied by means of a specially constructed device. Changes in cartilage thickness and signal intensity were evaluated quantitatively during FLASH and FISP sequences. In all patients the results of arthroscopies were available and in 12 patients, cartilage biopsies had been obtained. CMP stage I could be distinguished from normal cartilage by reduction in cartilage thickness and signal increase from the oedematous cartilage during compression. In CMP stages II/III, abnormal protein deposition of collagen type I could be demonstrated by its compressibility. In stages III and IV, the method does not add any significant additional information.

  5. Glued to Which Face? Attentional Priority Effect of Female Babyface and Male Mature Face

    PubMed Central

    Zheng, Wenwen; Luo, Ting; Hu, Chuan-Peng; Peng, Kaiping

    2018-01-01

    A more babyfaced individual is perceived as more child-like and this impression from babyface, as known as babyface effect, has an impact on social life among various age groups. In this study, the influence of babyfaces on visual selective attention was tested by cognitive task, demonstrating that the female babyface and male mature face would draw participants’ attention so that they take their eyes off more slowly. In Experiment 1, a detection task was applied to test the influence of babyfaces on visual selective attention. In this experiment, a babyface and a mature face with the same gender were presented simultaneously with a letter on one of them. The reaction time was shorter when the target letter was overlaid with a female babyface or male mature face, suggesting an attention capture effect. To explore how this competition influenced by attentional resources, we conducted Experiment 2 with a spatial cueing paradigm and controlled the attentional resources by cueing validity and inter-stimulus interval. In this task, the female babyface and male mature face prolonged responses to the spatially separated targets under the condition of an invalid and long interval pre-cue. This observation replicated the result of Experiment 1. This indicates that the female babyface and male mature face glued visual selective attention once attentional resources were directed to them. To further investigate the subliminal influence from a babyface, we used continuous flash suppression paradigm in Experiment 3. The results, again, showed the advantage of the female babyfaces and male mature faces: they broke the suppression faster than other faces. Our results provide primary evidence that the female babyfaces and male mature faces can reliably glue the visual selective attention, both supra- and sub-liminally. PMID:29559946

  6. Glued to Which Face? Attentional Priority Effect of Female Babyface and Male Mature Face.

    PubMed

    Zheng, Wenwen; Luo, Ting; Hu, Chuan-Peng; Peng, Kaiping

    2018-01-01

    A more babyfaced individual is perceived as more child-like and this impression from babyface, as known as babyface effect, has an impact on social life among various age groups. In this study, the influence of babyfaces on visual selective attention was tested by cognitive task, demonstrating that the female babyface and male mature face would draw participants' attention so that they take their eyes off more slowly. In Experiment 1, a detection task was applied to test the influence of babyfaces on visual selective attention. In this experiment, a babyface and a mature face with the same gender were presented simultaneously with a letter on one of them. The reaction time was shorter when the target letter was overlaid with a female babyface or male mature face, suggesting an attention capture effect. To explore how this competition influenced by attentional resources, we conducted Experiment 2 with a spatial cueing paradigm and controlled the attentional resources by cueing validity and inter-stimulus interval. In this task, the female babyface and male mature face prolonged responses to the spatially separated targets under the condition of an invalid and long interval pre-cue. This observation replicated the result of Experiment 1. This indicates that the female babyface and male mature face glued visual selective attention once attentional resources were directed to them. To further investigate the subliminal influence from a babyface, we used continuous flash suppression paradigm in Experiment 3. The results, again, showed the advantage of the female babyfaces and male mature faces: they broke the suppression faster than other faces. Our results provide primary evidence that the female babyfaces and male mature faces can reliably glue the visual selective attention, both supra- and sub-liminally.

  7. Avalanche multiplication and impact ionization in amorphous selenium photoconductive target

    NASA Astrophysics Data System (ADS)

    Park, Wug-Dong; Tanioka, Kenkichi

    2014-03-01

    The avalanche multiplication factor and the hole ionization coefficient in the amorphous selenium (a-Se) high-gain avalanche rushing amorphous photoconductor (HARP) target depend on the electric field. The phenomenon of avalanche multiplication and impact ionization in the 0.4-µm-thick a-Se HARP target is investigated. The hot carrier energy in the 0.4-µm-thick a-Se HARP target increases linearly as the target voltage increases. The energy relaxation length of hot carriers in the a-Se photoconductor of the 0.4-µm-thick HARP target saturates as the electric field increases. The average energy Eav of a hot carrier and the energy relaxation length λE in the a-Se photoconductor of the 0.4-µm-thick HARP target at 1 × 108 V/m were 0.25 eV and 2.5 nm, respectively. In addition, the hole ionization coefficient β and the avalanche multiplication factor M are derived as a function of the electric field, the average energy of a hot carrier, and the impact ionization energy. The experimental hole ionization coefficient β and the avalanche multiplication factor M in the 0.4-µm-thick a-Se HARP target agree with the theoretical results.

  8. Green FLASH: energy efficient real-time control for AO

    NASA Astrophysics Data System (ADS)

    Gratadour, D.; Dipper, N.; Biasi, R.; Deneux, H.; Bernard, J.; Brule, J.; Dembet, R.; Doucet, N.; Ferreira, F.; Gendron, E.; Laine, M.; Perret, D.; Rousset, G.; Sevin, A.; Bitenc, U.; Geng, D.; Younger, E.; Andrighettoni, M.; Angerer, G.; Patauner, C.; Pescoller, D.; Porta, F.; Dufourcq, G.; Flaischer, A.; Leclere, J.-B.; Nai, A.; Palazzari, P.; Pretet, D.; Rouaud, C.

    2016-07-01

    The main goal of Green Flash is to design and build a prototype for a Real-Time Controller (RTC) targeting the European Extremely Large Telescope (E-ELT) Adaptive Optics (AO) instrumentation. The E-ELT is a 39m diameter telescope to see first light in the early 2020s. To build this critical component of the telescope operations, the astronomical community is facing technical challenges, emerging from the combination of high data transfer bandwidth, low latency and high throughput requirements, similar to the identified critical barriers on the road to Exascale. With Green Flash, we will propose technical solutions, assess these enabling technologies through prototyping and assemble a full scale demonstrator to be validated with a simulator and tested on sky. With this R&D program we aim at feeding the E-ELT AO systems preliminary design studies, led by the selected first-light instruments consortia, with technological validations supporting the designs of their RTC modules. Our strategy is based on a strong interaction between academic and industrial partners. Components specifications and system requirements are derived from the AO application. Industrial partners lead the development of enabling technologies aiming at innovative tailored solutions with potential wide application range. The academic partners provide the missing links in the ecosystem, targeting their application with mainstream solutions. This increases both the value and market opportunities of the developed products. A prototype harboring all the features is used to assess the performance. It also provides the proof of concept for a resilient modular solution to equip a large scale European scientific facility, while containing the development cost by providing opportunities for return on investment.

  9. Dynamics and materials physics of fault rupture and glacial processes

    NASA Astrophysics Data System (ADS)

    Platt, John Daniel

    This thesis focuses on two main topics, the physics governing how faults rapidly weaken during an earthquake and the thermal and mechanical structure of ice stream shear margins. The common theme linking these two projects is the desire to understand how the complicated interactions between stress and temperature control deformation and failure. All of the problems in this thesis are attacked using a combination of analytic and numerical methods, and the interplay between these two approaches provides a powerful way to understand the different physical balances that dominate in different regimes. We also use aspects of materials science to understand how the often complicated rheologies are controlled by underlying physical phenomena such as melting, phase transitions, diffusion, and dislocation motion. With regards to fault mechanics, we begin by showing how co-seismic weakening mechanisms driven by elevated pore fluid pressures lead to micron-scale strain localization during an earthquake. We solve for the localized zone thickness for a range of fault temperatures, test these predictions using numerical simulations, and show how the onset of localization accelerates fault weakening. Next we present the first solutions to account for thermal decomposition reactions during a dynamic rupture, showing that the activation of thermal decomposition may lead to a larger slip duration and total slip. Finally we present a new set of experiments studying flash heating of serpentinite, highlighting the dependence of friction on normal stress and the presence of gouge, and producing the first model to explain the hysteresis commonly observed in flash heating experiments. With regards to ice stream shear margins, we begin by extending the work of Perol and Rice [2011] to study the formation of temperate ice in shear margins, and quantify the total melt that may be generated within the shear margins. We conclude by investigating how the presence of such a channel alters the stress on and strength of the undeforming bed in the shear margin, showing that the transition from a deforming to an undeforming bed across a channel is stable when the water flux in the channel exceeds a critical value.

  10. Centering on Sea Life in the Classroom.

    ERIC Educational Resources Information Center

    Gruendike, Janis L.

    1982-01-01

    Describes an oceanography learning center for elementary/middle school students, focusing on use of games (review jeopardy), instructional tapes, flash cards, activity felt boards, picture puzzles, reading materials, science displays, and experiment stations. (JN)

  11. Generation and Transport of Hot Electrons in Cone-Wire Targets

    NASA Astrophysics Data System (ADS)

    Beg, Farhat

    2009-11-01

    We present results from a series of experiments where cone-wire targets in various configurations were employed both to assess hot electron coupling efficiency, and to reveal the source temperature of the hot electrons. Initial experiments were performed on the Vulcan petawatt laser at the Rutherford Appleton Laboratory and Titan laser at the Lawrence Livermore National Laboratory. Results with aluminum cones joined to Cu wires of diameters from 10 to 40 μm show that the laser coupling efficiency to electron energy within the wire is proportional to the cross sectional area of the wire. In addition, coupling into the wire was observed to decrease with the laser prepulse and cone-wall thickness. More recently, this study was extended, using the OMEGA EP laser. The resulting changes in coupling energy give indications of the scaling as we approach FI-relevant conditions. Requirements for FI scale fast ignition cone parameters: tip thickness, wall thickness, laser prepulse and laser pulse length, will be discussed. In collaboration with T. Yabuuchi, T. Ma, D. Higginson, H. Sawada, J. King, M.H. Key, K.U. Akli, Al Elsholz, D. Batani, H. Chen, R.R. Freeman, L. Gizzi, J. Green, S. Hatchett, D. Hey, P. Jaanimagi, J. Koch, K. L. Lancaster, D.Larson, A.J. MacKinnon, H. McLean, A. MacPhee, P.A. Norreys, P.K Patel, R. B. Stephens, W. Theobald, R. Town, M. Wei, S. Wilks, Roger Van Maren, B. Westover and L. VanWoerkom.

  12. Daily Physical Activity and Hot Flashes in the Study of Women's Health Across the Nation FLASHES Study

    PubMed Central

    Gibson, Carolyn; Matthews, Karen; Thurston, Rebecca

    2014-01-01

    Objective To examine the role of physical activity in menopausal hot flashes. Competing models conceptualize physical activity as a risk or protective factor for hot flashes. Few studies have examined this relationship prospectively using physiologic measures of hot flashes and physical activity. Design Over two 48 hour-periods, 51 participants wore a physiologic hot flash monitor and activity monitor, and reported their hot flashes in an electronic diary. Physiologic hot flashes, reported hot flashes and reported hot flashes without physiological corroboration were related to activity changes using hierarchical generalized linear modeling, adjusting for potential confounders. Setting Community. Patients Midlife women. Interventions None. Main Outcome Measures Physiologically-detected hot flashes and reported hot flashes with and without physiologic corroboration. Results Hot flash reports without physiologic corroboration were more likely after activity increases (OR 1.04, 95% CI: 1.00-1.10, p=.01), particularly among women with higher levels of depressive symptoms (interaction p=.02). No other types of hot flashes were related to physical activity. Conclusion Acute increases in physical activity were associated with increased reporting of hot flashes lacking physiologic corroboration, particularly among women with depressive symptoms. Clinicians should consider the role of symptom perception and reporting in relations between physical activity and hot flashes. PMID:24491454

  13. Does evaluative conditioning depend on awareness? Evidence from a continuous flash suppression paradigm.

    PubMed

    Högden, Fabia; Hütter, Mandy; Unkelbach, Christian

    2018-02-26

    The role of awareness in evaluative learning has been thoroughly investigated with a variety of theoretical and methodological approaches. We investigated evaluative conditioning (EC) without awareness with an approach that conceptually provides optimal conditions for unaware learning - the Continuous Flash Suppression paradigm (CFS). In CFS, a stimulus presented to one eye can be rendered invisible for a prolonged duration by presenting a high-contrast dynamic pattern to the other eye. The suppressed stimulus is nevertheless processed. First, Experiment 1 established EC effects in a pseudo-CFS setup without suppression. Experiment 2 then employed CFS to suppress conditioned stimuli (CSs) from awareness while the unconditioned stimuli (USs) were visible. While Experiment 1 and 2 used a between-participants manipulation of CS suppression, Experiments 3 and 4 both manipulated suppression within participants. We observed EC effects when CSs were not suppressed, but found no EC effects when the CS was suppressed from awareness. We relate our finding to previous research and discuss theoretical implications for EC. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

  14. THz pulse doubler at FLASH: double pulses for pump–probe experiments at X-ray FELs

    PubMed Central

    Zapolnova, Ekaterina; Golz, Torsten; Pan, Rui; Klose, Karsten; Stojanovic, Nikola

    2018-01-01

    FLASH, the X-ray free-electron laser in Hamburg, Germany, employs a narrowband high-field accelerator THz source for unique THz pump X-ray probe experiments. However, the large difference in optical paths of the THz and X-ray beamlines prevents utilization of the machine’s full potential (e.g. extreme pulse energies in the soft X-ray range). To solve this issue, lasing of double electron bunches, separated by 28 periods of the driving radiofrequency (at 1.3 GHz), timed for the temporal overlap of THz and X-ray pulses at the experimental station has been employed. In order to optimize conditions for a typical THz pump X-ray probe experiment, X-ray lasing of the first bunch to one-sixth of that of the second has been suppressed. Finally, synchronization of THz radiation pulses was measured to be ∼20 fs (r.m.s.), and a solution for monitoring the arrival time for achieving higher temporal resolution is presented. PMID:29271749

  15. Auditory presentation and synchronization in Adobe Flash and HTML5/JavaScript Web experiments.

    PubMed

    Reimers, Stian; Stewart, Neil

    2016-09-01

    Substantial recent research has examined the accuracy of presentation durations and response time measurements for visually presented stimuli in Web-based experiments, with a general conclusion that accuracy is acceptable for most kinds of experiments. However, many areas of behavioral research use auditory stimuli instead of, or in addition to, visual stimuli. Much less is known about auditory accuracy using standard Web-based testing procedures. We used a millisecond-accurate Black Box Toolkit to measure the actual durations of auditory stimuli and the synchronization of auditory and visual presentation onsets. We examined the distribution of timings for 100 presentations of auditory and visual stimuli across two computers with difference specs, three commonly used browsers, and code written in either Adobe Flash or JavaScript. We also examined different coding options for attempting to synchronize the auditory and visual onsets. Overall, we found that auditory durations were very consistent, but that the lags between visual and auditory onsets varied substantially across browsers and computer systems.

  16. THz pulse doubler at FLASH: double pulses for pump-probe experiments at X-ray FELs.

    PubMed

    Zapolnova, Ekaterina; Golz, Torsten; Pan, Rui; Klose, Karsten; Schreiber, Siegfried; Stojanovic, Nikola

    2018-01-01

    FLASH, the X-ray free-electron laser in Hamburg, Germany, employs a narrowband high-field accelerator THz source for unique THz pump X-ray probe experiments. However, the large difference in optical paths of the THz and X-ray beamlines prevents utilization of the machine's full potential (e.g. extreme pulse energies in the soft X-ray range). To solve this issue, lasing of double electron bunches, separated by 28 periods of the driving radiofrequency (at 1.3 GHz), timed for the temporal overlap of THz and X-ray pulses at the experimental station has been employed. In order to optimize conditions for a typical THz pump X-ray probe experiment, X-ray lasing of the first bunch to one-sixth of that of the second has been suppressed. Finally, synchronization of THz radiation pulses was measured to be ∼20 fs (r.m.s.), and a solution for monitoring the arrival time for achieving higher temporal resolution is presented.

  17. New beam monitoring tool for radiobiology experiments at the cyclotron ARRONAX.

    PubMed

    Schwob, L; Koumeir, C; Servagent, N; Cherel, M; Guertin, A; Haddad, F; Métivier, V; Michel, N; Poirier, F; Rahmani, A; Varmenot, N

    2015-09-01

    The ARRONAX cyclotron is able to deliver alpha particles at 68 MeV. In the frame of radiological research, a new method is studied to infer in situ the deposited dose: it is based on the online measurement of the bremsstrahlung (>1 keV) produced by the interaction of the incident particle with the medium. Experiments are made using bombarded poly(methyl methacrylate) (PMMA)-equivalent water targets in order to characterise this continuous X-ray spectrum. The intensity of the bremsstrahlung spectrum allows for the beam monitoring. A simulation code of the bremsstrahlung has been built, and a good agreement is found with the experimental spectra. With this simulation, it is possible to predict the sensibility of this method: it varies with the target thickness, showing a good sensibility for thin target (<1000 µm) and saturation for thicker ones. Bremsstrahlung spectrum also shows a sensibility on the target's chemical composition. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  18. Implosion of multilayered cylindrical targets driven by intense heavy ion beams.

    PubMed

    Piriz, A R; Portugues, R F; Tahir, N A; Hoffmann, D H H

    2002-11-01

    An analytical model for the implosion of a multilayered cylindrical target driven by an intense heavy ion beam has been developed. The target is composed of a cylinder of frozen hydrogen or deuterium, which is enclosed in a thick shell of solid lead. This target has been designed for future high-energy-density matter experiments to be carried out at the Gesellschaft für Schwerionenforschung, Darmstadt. The model describes the implosion dynamics including the motion of the incident shock and the first reflected shock and allows for calculation of the physical conditions of the hydrogen at stagnation. The model predicts that the conditions of the compressed hydrogen are not sensitive to significant variations in target and beam parameters. These predictions are confirmed by one-dimensional numerical simulations and thus allow for a robust target design.

  19. DOE Office of Scientific and Technical Information (OSTI.GOV)

    R. Camp

    Over the past four years, the Electrical Safety Program at PPPL has evolved in addressing changing regulatory requirements and lessons learned from accident events, particularly in regards to arc flash hazards and implementing NFPA 70E requirements. This presentation will discuss PPPL's approaches to the areas of electrical hazards evaluation, both shock and arc flash; engineered solutions for hazards mitigation such as remote racking of medium voltage breakers, operational changes for hazards avoidance, targeted personnel training and hazard appropriate personal protective equipment. Practical solutions for nominal voltage identification and zero voltage checks for lockout/tagout will also be covered. Finally, we willmore » review the value of a comprehensive electrical drawing program, employee attitudes expressed as a personal safety work ethic, integrated safety management, and sustained management support for continuous safety improvement.« less

  20. Simulation study of neutron production in thick beryllium targets by 35 MeV and 50.5 MeV proton beams

    NASA Astrophysics Data System (ADS)

    Shin, Jae Won; Park, Tae-Sun

    2017-09-01

    A data-driven nuclear model dedicated to an accurate description of neutron productions in beryllium targets bombarded by proton beams is developed as a custom development that can be used as an add-on to GEANT4 code. The developed model, G4Data(Endf7.1), takes as inputs the total and differential cross section data of ENDF/B-VII.1 for not only the charge-exchange 9Be(p,n)9B reaction which produces discrete neutrons but also the nuclear reactions relevant for the production of continuum neutrons such as 9Be(p,pn)8Be and 9Be(p,n α) 5Li . In our benchmarking simulations for two experiments with 35 MeV and 50.5 MeV proton beams impinged on 1.16 and 1.05 cm thick beryllium targets, respectively, we find that the G4Data(Endf7.1) model can reproduce both the total amounts and the spectral shapes of the measured neutron yield data in a satisfactory manner, while all the considered hadronic models of GEANT4 cannot.

  1. Implications of HARP Results for the Energy of the Proton Driver for a Neutrino Factory and Muon Collider

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Strait, J.; Mokhov, N.V.; Striganov, S.I.

    2010-06-09

    Cross-section data from the HARP experiment for pion production by protons from a tantalum target have been convoluted with the acceptance of the front-end channel for the proposed neutrino factory or muon collider and integrated over the full phase space measured by HARP, to determine the beam-energy dependence of the muon yield. This permits a determination of the optimal beam energy for the proton driver for these projects. The cross-section data are corrected for the beam-energy dependent 'amplification' due to the development of hadronic showers in a thick target. The conclusion is that, for constant beam power, the yield ismore » maximum for a beam energy of about 7 GeV, but it is within 10% of this maximum for 4 < T{sub beam} < 11 GeV, and within 20% of the maximum for T{sub beam} as low as 2 GeV. This result is insensitive to which of the two HARP groups results are used, and to which pion generator is used to compute the thick target effects.« less

  2. Quantitative comparison of the application accuracy between NDI and IGT tracking systems

    NASA Astrophysics Data System (ADS)

    Li, Qinghang; Zamorano, Lucia J.; Jiang, Charlie Z. W.; Gong, JianXing; Diaz, Fernando

    1999-07-01

    The application accuracy is a crucial factor for the stereotactic surgical localization system in which space digitization system is one of the most important part of equipment. In this study we compared the application accuracy of using the OPTOTRAK space digitization system (OPTOTRAK 3020, Northern Digital, Waterloo, CAN) and FlashPoint Model 3000 and 5000 3-D digitizer systems (FlashPoint Model 3000 and 5000, Image Guided Surgery Technology Inc., Boulder, CO 80301, USA) for interactive localization of intracranial lesions. A phantom was mounted with the implantable frameless marker system (Fischer- Leibinger, Freiburg, Germany) which randomly distributed markers on the surface of the phantom. The target point was digitized and the coordinates were recorded and compared with reference points. The differences from the reference points were used as the deviation from the `true point'. The mean square root was calculated to show the sum of vectors. A paired t-test was used to analyze results. The results of the phantom showed that the mean square roots were 0.76 +/- 0.54 mm for the OPTOTRAK system and 1.23 +/- 0.53 mm for FlashPoint Model 3000 3-D digitizer system and 1.00 +/- 0.42 mm for FlashPoint Model 3000 3-D digitizer system in the 1 mm sections of CT scan. This preliminary results showed that there is no significant difference between two tracking systems. Both of them can be used for image guided surgery procedure.

  3. An EOG-Based Human-Machine Interface for Wheelchair Control.

    PubMed

    Huang, Qiyun; He, Shenghong; Wang, Qihong; Gu, Zhenghui; Peng, Nengneng; Li, Kai; Zhang, Yuandong; Shao, Ming; Li, Yuanqing

    2017-07-27

    Non-manual human-machine interfaces (HMIs) have been studied for wheelchair control with the aim of helping severely paralyzed individuals regain some mobility. The challenge is to rapidly, accurately and sufficiently produce control commands, such as left and right turns, forward and backward motions, acceleration, deceleration, and stopping. In this paper, a novel electrooculogram (EOG)-based HMI is proposed for wheelchair control. Thirteen flashing buttons are presented in the graphical user interface (GUI), and each of the buttons corresponds to a command. These buttons flash on a one-by-one manner in a pre-defined sequence. The user can select a button by blinking in sync with its flashes. The algorithm detects the eye blinks from a channel of vertical EOG data and determines the user's target button based on the synchronization between the detected blinks and the button's flashes. For healthy subjects/patients with spinal cord injuries (SCIs), the proposed HMI achieved an average accuracy of 96.7%/91.7% and a response time of 3.53 s/3.67 s with 0 false positive rates (FPRs). Using only one channel of vertical EOG signals associated with eye blinks, the proposed HMI can accurately provide sufficient commands with a satisfactory response time. The proposed HMI provides a novel non-manual approach for severely paralyzed individuals to control a wheelchair. Compared with a newly established EOG-based HMI, the proposed HMI can generate more commands with higher accuracy, lower FPR and fewer electrodes.

  4. Deuteron irradiation of W and WO 3 for production of high specific activity 186Re: Challenges associated with thick target preparation

    DOE PAGES

    Balkin, Ethan R.; Gagnon, Katherine; Strong, Kevin T.; ...

    2016-06-28

    This investigation evaluated target fabrication and beam parameters for scale-up production of high specific activity 186Re using deuteron irradiation of enriched 186W via the 186W(d,2n) 186Re reaction. Thick W and WO 3 targets were prepared, characterized and evaluated in deuteron irradiations. Full-thickness targets, as determined using SRIM, were prepared by uniaxi-ally pressing powdered natural abundance W and WO 3, or 96.86% enriched 186W, into Al target supports. Alternatively, thick targets were prepared by pressing 186W between two layers of graphite powder or by placing pre-sintered (1105°C, 12 hours) natural abundance WO 3 pellets into an Al target support. Assessments ofmore » structural integrity were made on each target pre-pared. Prior to irradiation, material composition analyses were conducted using SEM, XRD, and Raman spectroscopy. With-in a minimum of 24 hours post irradiation, gamma-ray spectroscopy was performed on all targets to assess production yields and radionuclidic byproducts. Problems were encountered with the structural integrity of some pressed W and WO 3 pellets before and during irradiation, and target material characterization results could be correlated with the structural integrity of the pressed target pellets. Under the conditions studied, the findings suggest that all WO 3 targets prepared and studied were unacceptable. By contrast, 186W metal was found to be a viable target material for 186Re production. Lastly, thick targets prepared with powdered 186W pressed between layers of graphite provided a particularly robust target configuration.« less

  5. Deuteron irradiation of W and WO3 for production of high specific activity (186)Re: Challenges associated with thick target preparation.

    PubMed

    Balkin, Ethan R; Gagnon, Katherine; Strong, Kevin T; Smith, Bennett E; Dorman, Eric F; Emery, Robert C; Pauzauskie, Peter J; Fassbender, Michael E; Cutler, Cathy S; Ketring, Alan R; Jurisson, Silvia S; Wilbur, D Scott

    2016-09-01

    This investigation evaluated target fabrication and beam parameters for scale-up production of high specific activity (186)Re using deuteron irradiation of enriched (186)W via the (186)W(d,2n)(186)Re reaction. Thick W and WO3 targets were prepared, characterized and evaluated in deuteron irradiations. Full-thickness targets, as determined using SRIM, were prepared by uniaxially pressing powdered natural abundance W and WO3, or 96.86% enriched (186)W, into Al target supports. Alternatively, thick targets were prepared by pressing (186)W between two layers of graphite powder or by placing pre-sintered (1105°C, 12h) natural abundance WO3 pellets into an Al target support. Assessments of structural integrity were made on each target prepared. Prior to irradiation, material composition analyses were conducted using SEM, XRD, and Raman spectroscopy. Within a minimum of 24h post irradiation, gamma-ray spectroscopy was performed on all targets to assess production yields and radionuclidic byproducts. Problems were encountered with the structural integrity of some pressed W and WO3 pellets before and during irradiation, and target material characterization results could be correlated with the structural integrity of the pressed target pellets. Under the conditions studied, the findings suggest that all WO3 targets prepared and studied were unacceptable. By contrast, (186)W metal was found to be a viable target material for (186)Re production. Thick targets prepared with powdered (186)W pressed between layers of graphite provided a particularly robust target configuration. Copyright © 2016 Elsevier Ltd. All rights reserved.

  6. Upper limit set for level of lightning activity on Titan

    NASA Technical Reports Server (NTRS)

    Desch, M. D.; Kaiser, M. L.

    1990-01-01

    Because optically thick cloud and haze layers prevent lightning detection at optical wavelength on Titan, a search was conducted for lightning-radiated signals (spherics) at radio wavelengths using the planetary radioastronomy instrument aboard Voyager 1. Given the maximum ionosphere density of about 3000/cu cm, lightning spherics should be detectable above an observing frequency of 500 kHz. Since no evidence for spherics is found, an upper limit to the total energy per flash in Titan lightning of about 10 to the 6th J, or about 1000 times weaker than that of typical terrestrial lightning, is inferred.

  7. ELROI Extremely Low Resource Optical Identifier. A license plate for your satellite, and more.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Palmer, David

    ELROI (Extremely Low Resource Optical Identifier) is a license plate for your satellite; a small tag that flashes an optical identification code that can be read by a small telescope on the ground. The final version of the tag will be the size of a thick postage stamp and fully autonomous: you can attach it to everything that goes into space, including small cubesats and inert debris like rocket stages, and it will keep blinking even after the satellite is shut down, reliably identifying the object from launch until re-entry.

  8. Stimulus-driven changes in the direction of neural priming during visual word recognition.

    PubMed

    Pas, Maciej; Nakamura, Kimihiro; Sawamoto, Nobukatsu; Aso, Toshihiko; Fukuyama, Hidenao

    2016-01-15

    Visual object recognition is generally known to be facilitated when targets are preceded by the same or relevant stimuli. For written words, however, the beneficial effect of priming can be reversed when primes and targets share initial syllables (e.g., "boca" and "bono"). Using fMRI, the present study explored neuroanatomical correlates of this negative syllabic priming. In each trial, participants made semantic judgment about a centrally presented target, which was preceded by a masked prime flashed either to the left or right visual field. We observed that the inhibitory priming during reading was associated with a left-lateralized effect of repetition enhancement in the inferior frontal gyrus (IFG), rather than repetition suppression in the ventral visual region previously associated with facilitatory behavioral priming. We further performed a second fMRI experiment using a classical whole-word repetition priming paradigm with the same hemifield procedure and task instruction, and obtained well-known effects of repetition suppression in the left occipito-temporal cortex. These results therefore suggest that the left IFG constitutes a fast word processing system distinct from the posterior visual word-form system and that the directions of repetition effects can change with intrinsic properties of stimuli even when participants' cognitive and attentional states are kept constant. Copyright © 2015 Elsevier Inc. All rights reserved.

  9. Adverse Effects of Induced Hot Flashes on Objectively Recorded and Subjectively Reported Sleep: Results of a Gonadotropin-Releasing Hormone Agonist Experimental Protocol

    PubMed Central

    Joffe, Hadine; White, David P.; Crawford, Sybil L.; McCurnin, Kristin E.; Economou, Nicole; Connors, Stephanie; Hall, Janet E.

    2013-01-01

    Objectives The impact of hot flashes on sleep is of great clinical interest, but results are inconsistent, especially when both hot flashes and sleep are measured objectively. Using objective and subjective measurements, we examined the impact of hot flashes on sleep by inducing hot flashes with a gonadotropin-releasing hormone agonist (GnRHa). Methods The GnRHa leuprolide was administered to 20 healthy premenopausal volunteers without hot flashes or sleep disturbances. Induced hot flashes were assessed objectively (skin-conductance monitor) and subjectively (daily diary) during one-month follow-up. Changes from baseline in objective (actigraphy) and subjective sleep quality (Pittsburgh Sleep Quality Index [PSQI]) were compared between women who did and did not develop objective hot flashes, and, in parallel analyses, subjective hot flashes. Results New-onset hot flashes were recorded in 14 (70%) and reported by 14 (70%) women (80% concordance). Estradiol was universally suppressed. Objective sleep efficiency worsened in women with objective hot flashes and improved in women without objective hot flashes (median decrease 2.6%, increase 4.2%, p=0.005). Subjective sleep quality worsened more in those with than without subjective hot flashes (median increase PSQI 2.5 vs. 1.0, p=0.03). Objective hot flashes were not associated with subjective sleep quality, nor were subjective symptoms linked to objective sleep measures. Conclusions This experimental model of induced hot flashes demonstrates a causal relationship between hot flashes and poor sleep quality. Objective hot flashes result in worse objective sleep efficiency, while subjective hot flashes worsen perceived sleep quality. PMID:23481119

  10. Optimization of the photoneutron target geometry for e-accelerator based BNCT.

    PubMed

    Chegeni, Nahid; Pur, Saleh Boveiry; Razmjoo, Sasan; Hoseini, Seydeh Khadijed

    2017-06-01

    Today, electron accelerators are taken into consideration as photoneutron sources. Therefore, for maximum production of epithermal neutron flux, designing a photoneutron target is of significant importance. In this paper, the effect of thickness and geometric shape of a photoneutron target on neutron output were investigated. In this study, a pencil photon source with 13, 15, 18, 20 and 25 MeV energies and a diameter of 2 mm was investigated using Monte Carlo simulation method using MCNP code. To optimize the design of the photoneutron target, the tungsten target with various geometries and thicknesses was investigated. The maximum neutron flux produced for all target geometries and thicknesses occurred at neutron energy peak of around 0.46 MeV. As the thickness increased to 2 cm, neutron flux increased and then a decreasing trend was observed. For various geometrical shapes, the determining factor in photoneutron output was the effective target thickness in the photon interaction path that increased by the increase in the area of interaction. Another factor was the angle of the photon's incidence with the target surface that resulted in a significant decrease in photoneutron output in cone-shaped targets. Three factors including the total neutron flux, neutrons energy spectrum, and convergence of neutrons plays an important role in the selection of geometry and shape of the target that should be investigated considering beam shaping assembly (BSA) shape.

  11. Simulation of cosmic irradiation conditions in thick target arrangements

    NASA Technical Reports Server (NTRS)

    Theis, S.; Englert, P.; Reedy, R. C.; Arnold, J. R.

    1986-01-01

    One approach to simulate 2-pi irradiation conditions of planetary surfaces which has been widely applied in the past are bombardments of so called thick targets. A very large thick target was exposed recently to 2.1 GeV protons at the Bevatron-Bevalac in Berkeley. In a 100x100x180 cm steel-surrounded granodiorite target radioactive medium and high energy spallation products of the incident primary and of secondary particles were analyzed along the beam axis down to depths of 140 g/cm(2) in targets such as Cu, Ni, Co, Fe, T, Si, SiO2 and Al. Activities of these nuclides were exclusively determined via instrumental gamma-ray spectroscopy. Relative yields of neutron capture and spallation products induced in Co and Cu targets during the thick target bombardment are shown as a function of depth. The majority of the medium energy products such as Co-58 from Co targets exhibit a maximum at shallow depths of 40-60 g/cm(2) and then decrease exponentially. In a comparable 600 MeV proton bombarded thick target such a slight maximum for medium energy products was not observed. Rather, Co-58 activities in Co decreased steadily with the highest activity at the surface. The activities of the n-capture product Co-60 increase steadily starting at the surface. This indicates the rapidly growing flux of low energy neutrons within the target.

  12. Investigation of mixed ion fields in the forward direction for 220.5 MeV/u helium ion beams: comparison between water and PMMA targets.

    PubMed

    Aricò, G; Gehrke, T; Jakubek, J; Gallas, R; Berke, S; Jäkel, O; Mairani, A; Ferrari, A; Martišíková, M

    2017-10-03

    Currently there is a rising interest in helium ion beams for radiotherapy. For benchmarking of the physical beam models used in treatment planning, there is a need for experimental data on the composition and spatial distribution of mixed ion fields. Of particular interest are the attenuation of the primary helium ion fluence and the build-up of secondary hydrogen ions due to nuclear interactions. The aim of this work was to provide such data with an enhanced precision. Moreover, the validity and limits of the mixed ion field equivalence between water and PMMA targets were investigated. Experiments with a 220.5 MeV/u helium ion pencil beam were performed at the Heidelberg Ion-Beam Therapy Center in Germany. The compact detection system used for ion tracking and identification was solely based on Timepix position-sensitive semiconductor detectors. In comparison to standard techniques, this system is two orders of magnitude smaller, and provides higher precision and flexibility. The numbers of outgoing helium and hydrogen ions per primary helium ion as well as the lateral particle distributions were quantitatively investigated in the forward direction behind water and PMMA targets with 5.2-18 cm water equivalent thickness (WET). Comparing water and PMMA targets with the same WET, we found that significant differences in the amount of outgoing helium and hydrogen ions and in the lateral particle distributions arise for target thicknesses above 10 cm WET. The experimental results concerning hydrogen ions emerging from the targets were reproduced reasonably well by Monte Carlo simulations using the FLUKA code. Concerning the amount of outgoing helium ions, significant differences of 3-15% were found between experiments and simulations. We conclude that if PMMA is used in place of water in dosimetry, differences in the dose distributions could arise close to the edges of the field, in particular for deep seated targets.

  13. Radiographic detection of 100 A thickness variations in 1-. mu. m-thick coatings applied to submillimeter-diameter laser fusion targets

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Stupin, D.M.

    1986-01-01

    We have developed x-ray radiography to measure thickness variations of coatings on laser fusion targets. Our technique is based on measuring the variation in x-ray transmission through the targets. The simplest targets are hollow glass microshells or microballoons 100 to 500 ..mu..m in diameter, that have several layers of metals or plastics, 1 to 100 ..mu..m thick. Our goal is to examine these opaque coatings for thickness variations as small as 1% or 0.1%, depending on the type of defect. Using contact radiography we have obtained the desired sensitivity for concentric and elliptical defects of 1%. This percentage corresponds tomore » thickness variations as small as 100 A in a 1-..mu..m-thick coating. For warts and dimples, the desired sensitivity is a function of the area of the defect, and we are developing a system to detect 0.1% thickness variations that cover an area 10 ..mu..m by 10 ..mu..m. We must use computer analysis of contact radiographs to measure 1% thickness variations in either concentricity or ellipticity. Because this analysis takes so long on our minicomputer, we preselect the radiographs by looking for defects at the 10% level on a video image analysis system.« less

  14. Menopausal hot flashes: Randomness or rhythmicity

    NASA Astrophysics Data System (ADS)

    Kronenberg, Fredi

    1991-10-01

    Menopausal hot flashes are episodes of flushing, increased heart rate, skin blood flow and skin temperature, and a sensation of heat. The thermoregulatory and cardiovascular concomitants of hot flashes are associated with peaks in the levels of various hormones and neurotransmitters in the peripheral circulation. Although hot flashes affect about 75% of women, and are the primary reason that women at menopause seek medical attention, the mechanism of hot flashes is still not understood. Hot flashes vary in frequency and intensity both within and between individuals, and have been thought of as occurring randomly. Yet, some women report that their hot flashes are worse at a particular time of day or year. Initial examination of subjects' recordings of their hot flashes showed diurnal patterns of hot flash occurrence. There also seems to be a diurnal rhythm of hot flash intensity. Continuous physiological monitoring of hot flashes is facilitating the analysis of these patterns, which is revealing circadian and ultradian periodicities. The occurrence of hot flashes can be modulated by external and internal factors, including ambient temperature and fever. Rhythms of thermoregulatory and endocrine functions also may influence hot flash patterns. Examination of the interrelationships between the various systems of the body involved in hot flashes, and a multidisciplinary approach to the analysis of hot flash patterns, will aid our understanding of this complex phenomenon.

  15. Automated analysis of lightning leader speed, local flash rates and electric charge structure in thunderstorms

    NASA Astrophysics Data System (ADS)

    Van Der Velde, O. A.; Montanya, J.; López, J. A.

    2017-12-01

    A Lightning Mapping Array (LMA) maps radio pulses emitted by lightning leaders, displaying lightning flash development in the cloud in three dimensions. Since the last 10 years about a dozen of these advanced systems have become operational in the United States and in Europe, often with the purpose of severe weather monitoring or lightning research. We introduce new methods for the analysis of complex three-dimensional lightning data produced by LMAs and illustrate them by cases of a mid-latitude severe weather producing thunderstorm and a tropical thunderstorm in Colombia. The method is based on the characteristics of bidrectional leader development as observed in LMA data (van der Velde and Montanyà, 2013, JGR-Atmospheres), where mapped positive leaders were found to propagate at characteristic speeds around 2 · 104 m s-1, while negative leaders typically propagate at speeds around 105 m s-1. Here, we determine leader speed for every 1.5 x 1.5 x 0.75 km grid box in 3 ms time steps, using two time intervals (e.g., 9 ms and 27 ms) and circles (4.5 km and 2.5 km wide) in which a robust Theil-Sen fitting of the slope is performed for fast and slow leaders. The two are then merged such that important speed characteristics are optimally maintained in negative and positive leaders, and labeled with positive or negative polarity according to the resulting velocity. The method also counts how often leaders from a lightning flash initiate or pass through each grid box. This "local flash rate" may be used in severe thunderstorm or NOx production studies and shall be more meaningful than LMA source density which is biased by the detection efficiency. Additionally, in each grid box the median x, y and z components of the leader propagation vectors of all flashes result in a 3D vector grid which can be compared to vectors in numerical models of leader propagation in response to cloud charge structure. Finally, the charge region altitudes, thickness and rates are summarized from vertical profiles of positive and negative leader rates where these exceed their 7-point averaged profiles. The summarized data can be used to follow charge structure evolution over time, and will be useful for climatological studies and statistical comparison against the parameters of the meteorological environment of storms.

  16. TU-H-CAMPUS-TeP2-02: FLASH Irradiation Improves the Therapeutic Index Following GI Tract Irradiation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Schueler, E; Trovati, S; King, G

    Purpose: To investigate and characterize the radiobiological effectiveness of very high dose rate radiotherapy (FLASH) compared to conventional irradiation in an in vivo model. Methods: The gastrointestinal (GI) tract of C57BL/6 mice were irradiated with doses ranging between 10 and 18 Gy using a custom stereotactic jig. A Varian Clinac 21EX was modified to allow dose rates ranging from 0.05 to 240 Gy/s at the position of the mirror. With the gantry at 180 degrees, the jig holding the individual animals was placed above the mirror to take advantage of the reduced source to target distance. Mice were irradiated withmore » 20MeV electrons. Following irradiation, the mice were monitored twice daily for morbidity and daily for weight changes. Results: Mice irradiated with FLASH irradiation had lower weight loss compared to the mice receiving conventional irradiation. Following FLASH irradiation, a maximum weight loss of ∼20% was observed at day 6 with subsequent recovery, while following conventional irradiation, higher weight losses was observed with fewer instances of recovery. Concerning survival, all mice in the conventionally irradiated groups had a 100% mortality in the range of 15.5–18 Gy, while the mice irradiated with FLASH irradiation had a 100% survival in the same range. Conclusion: These results have demonstrated proof of principle that FLASH irradiations have a dramatic impact on the overall survival of mice following GI tract irradiations. If the increase in the therapeutic window can be validated and understood, this would revolutionize the field of radiation oncology and lead to increased cure rates with reduced side effects following treatment, resulting in increased quality of life for cancer survivors. Funding: DoD, Award#:W81XWH-14-1-0014, Weston Havens Foundation, Bio-X (Stanford University), the Office of the Dean of the Medical School, the Office of the Provost (Stanford University), and the Swedish Childhood Cancer Foundation; BL and PM are founders of TibaRay,Inc.; BL and PM have received research grants from Varian and RaySearch Laboratory.« less

  17. Using flash cards to engage Indonesian nursing students in reflection on their practice.

    PubMed

    Wanda, Dessie; Fowler, Cathrine; Wilson, Valerie

    2016-03-01

    Reflective practice is now widely used as a critical learning tool in undergraduate and postgraduate nursing programs in most developed countries. However in developing countries, reflective practice is in its infancy. To introduce reflective practice to postgraduate students in an Indonesian nursing education institution. This paper presents the positive meanings of reflection and reflective practice experienced by the students and the way they used reflection within their practice. A descriptive qualitative study was conducted to explore the meaning of reflection or reflective practice using flashcards. A clinical reflective practice model taking into consideration Indonesian culture was developed and applied during students' clinical placement. A few weeks post clinical placement, 21 students participated in an evaluation session. The meaning of reflection or reflective practice was explored using flash cards containing images of people and environment with different situations and events. Students were asked to choose a card that represented their viewpoints about reflective practice and share it with the group. Data were digitally captured and analyzed using thematic analysis. Reflection provided a positive experience for the students. In their own words, they discussed their journey of using reflection during the clinical placement period. The use of reflection was identified as expanding their view of nursing practice, providing a safe place to explore their experiences and clarity when they encountered challenging situations during their clinical practice. Reflecting on practice experiences resulted in increased self-awareness, and enhanced their learning. The findings indicate that reflective practice can be implemented successfully in Indonesia and may have value for other Eastern countries that share similar cultural characteristics. The use of flash cards assisted the students describe through stories their experiences of participating in this reflective practice program. Copyright © 2015 Elsevier Ltd. All rights reserved.

  18. Cratering and penetration experiments in teflon targets at velocities from 1 to 7 km/s

    NASA Technical Reports Server (NTRS)

    Horz, Friedrich; Cintala, Mark; Bernhard, Ronald P.; Cardenas, Frank; Davidson, William; Haynes, Gerald; See, Thomas H.; Winkler, Jerry; Knight, Jeffrey

    1994-01-01

    Approximately 20 sq m of protective thermal blankets, largely composed of Teflon, were retrieved from the Long Duration Exposure Facility after the spacecraft spent approximately 5.7 years in space. Examination of these blankets revealed that they contained thousands of hypervelocity impact features ranging from micron-sized craters to penetration holes several millimeters in diameter. We conducted impact experiments to reproduce such features and to understand the relationships between projectile size and the resulting crater or penetration hole diameter over a wide range of impact velocities. Such relationships are needed to derive the size and mass frequency distribution and flux of natural and man-made particles in low-earth orbit. Powder propellant and light-gas guns were used to launch soda-lime glass spheres into pure Teflon targets at velocities ranging from 1 to 7 km/s. Target thickness varied over more than three orders of magnitude from finite halfspace targets to very thin films. Cratering and penetration of massive Teflon targets is dominated by brittle failure and the development of extensive spall zones at the target's front and, if penetrated, the target's rear side. Mass removal by spallation at the back side of Teflon targets may be so severe that the absolute penetration hole diameter can become larger than that of a standard crater. The crater diameter in infinite halfspace Teflon targets increases, at otherwise constant impact conditions, with encounter velocity by a factor of V (exp 0.44). In contrast, the penetration hole size in very thin foils is essentially unaffected by impact velocity. Penetrations at target thicknesses intermediate to these extremes will scale with variable exponents of V. Our experimental matrix is sufficiently systematic and complete, up to 7 km/s, to make reasonable recommendations for velocity-scaling of Teflon craters and penetrations. We specifically suggest that cratering behavior and associated equations apply to all impacts in which the shock-pulse duration of the projectile is shorter than that assigned a unique projectile size, provided an impact velocity is known or assumed. This calibration seems superior to the traditional ballistic-limit approach.

  19. Attentional bias induced by solving simple and complex addition and subtraction problems.

    PubMed

    Masson, Nicolas; Pesenti, Mauro

    2014-01-01

    The processing of numbers has been shown to induce shifts of spatial attention in simple probe detection tasks, with small numbers orienting attention to the left and large numbers to the right side of space. Recently, the investigation of this spatial-numerical association has been extended to mental arithmetic with the hypothesis that solving addition or subtraction problems may induce attentional displacements (to the right and to the left, respectively) along a mental number line onto which the magnitude of the numbers would range from left to right, from small to large numbers. Here we investigated such attentional shifts using a target detection task primed by arithmetic problems in healthy participants. The constituents of the addition and subtraction problems (first operand; operator; second operand) were flashed sequentially in the centre of a screen, then followed by a target on the left or the right side of the screen, which the participants had to detect. This paradigm was employed with arithmetic facts (Experiment 1) and with more complex arithmetic problems (Experiment 2) in order to assess the effects of the operation, the magnitude of the operands, the magnitude of the results, and the presence or absence of a requirement for the participants to carry or borrow numbers. The results showed that arithmetic operations induce some spatial shifts of attention, possibly through a semantic link between the operation and space.

  20. The Use of Water Vapor for Detecting Environments that Lead to Convectively Produced Heavy Precipitation and Flash Floods

    NASA Technical Reports Server (NTRS)

    Scofield, Rod; Vicente, Gilberto; Hodges, Mike

    2000-01-01

    This Tech Report summarizes years of study and experiences on using GOES Water vapor (6.7 micron and precipitable water) and Special Sensor Microwave Imager (SSM/1) from the Defense Meteorological Satellite Program (DMSP) derived Precipitable Water (PNAI) for detecting environments favorable for convectively produced flash floods. An emphasis is on the moisture. upper air flow, and equivalent potential temperature (Theta(sub e)) patterns that lead to devastating flood events. The 15 minute 6.7 micron water vapor imagery is essential for tracking middle to upper tropospheric disturbances that produce upward vertical motion and initiate flash flood producing systems. Water vapor imagery at 6.7 micron is also used to detect surges of upper level moisture (called tropical water vapor plumes) that have been associated with extremely heavy rainfall. Since the water vapor readily depicts lifting mechanisms and upper level moisture, water vapor imagery is often an excellent source of data for recognizing patterns of heavy precipitation and flash floods. In order to analyze the depth of the moisture, the PW aspects of the troposphere must be measured. The collocation (or nearby location) of high values ofP\\V and instability are antecedent conditions prior to the flash flood or heavy rainfall events. Knowledge of PW magnitudes have been used as thresholds for impending flash flood events, PW trends are essential in flash flood prediction. Conceptual models and water vapor products are used to study some of the characteristics of convective systems that occurred over the United States of America (USA) during the summer of 1997 and the 1997-1998 El Nino. P\\V plumes were associated with most of the \\vest coast heavy precipitation events examined during the winter season of 1997 - 1998, In another study, conducted during the summer season of 1997. results showed that the collocation of water vapor (6.7 micron) and P\\N' plumes possessed higher correlations with predicted rainfall amounts than when PW plumes occurred by themselves (i.e.. without the presence of 6.7 micron water vapor plumes). Satellite Analysis Branch (SAB) meteorologists use the 6.7 micron water and P\\V products for their QPE's (interactive Flash Flood Analyzer (IFFA) and Auto-Estimator precipitation estimates), Outlooks, and heavy precipitation briefings with the Hydrometeorological Prediction Center/National Center for Environmental Prediction.

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