Sample records for fleet craf program

  1. DoD Capability Benefits from Preserving the Civil Reserve Air Fleet (CRAF)

    DTIC Science & Technology

    2011-04-23

    Master of Military Studies Research Paper September 2010- April 2011 4. TITLE AND SUBTITLE DoP capability benefits from preserving the Civil Reserve Air...capability benefits from preserving the Civil Reserve Air Fleet (CRAF) SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER...1 Executive Summary Title: DOD capability benefits from preserving the Civil Reserve Air Fleet (CRAF) Author: Major Constantine E. Tsoukatos

  2. Set Up to Fail: Charter Passenger Airlines and the Civil Reserve Air Fleet

    DTIC Science & Technology

    2011-08-21

    1. 16 Teagan, Shawn E. CRAF 2002-An Analysis of CRAF Participation Since September 2001. Graduate Research Project. AFIT/ GMO /ENS/02E-12. Graduate...Teagan, Shawn E. CRAF 2002-An Analysis of CRAF Participation Since September 2001. Graduate Research Project. AFIT/ GMO /ENS/02E-12. Graduate School

  3. Sustaining the Civil Reserve Air Fleet (CRAF) Program

    DTIC Science & Technology

    2003-05-01

    means to build international networks and global marketing alliances. These arrangements have permitted alliances to exploit the regional competitive...next major phase occurred in the 1990s—the linking of networks in different countries through code sharing alliances and global marketing alliances

  4. Allocation and Routing of CRAF MD80 Aircraft

    DTIC Science & Technology

    1990-03-01

    8217I0P N2 COF Allocation and Routing of CRAF MD80 Aircraft William B. Carter Captain, USAF AFIT/GST/ENS/90M-4 DISTRIBUTION STATEMENT A D0TE4 I C...posture. My experience as an airlift pilot drew me to this topic dealing with a very special part of our airlift forces, aeromedical evacuation. This...thesis attempts to make a "first cut" in the analysis of how the new Civil Reserve Air Fleet (CRAF) aeromedical evacuation mission should operate. My

  5. Transforming the Civil Reserve Air Fleet (CRAF) to Enable Combat Power in a Fiscally Constrained Environment

    DTIC Science & Technology

    2010-10-27

    provides global reach through a mix of organic 1 Mr. Craig Koontz , “USTRANSCOM,” Powerpoint...Executive Working Group 20 May 2010." Powerpoint. 20 May 2010. Koontz , Craig. “USTRANSCOM.” Powerpoint. 13 September 2010. Lude, Col Carl

  6. Space science: Causes and impacts of cutbacks to NASA's outer solar system exploration missions. Report to the Chairman, Subcommittee on Investigations and Oversight, Committee on Science, Space, and Technology, House of Representatives

    NASA Astrophysics Data System (ADS)

    Degnan, Frank

    1993-12-01

    The Comet Rendezvous Asteroid Flyby (CRAF)/Cassini program was first funded by the Congress in fiscal year 1990. Since then, it has encountered difficulties that resulted in the cancellation of CRAF, reduction of Cassini's original scientific capabilities, and extension of its launch date. At the request of the former Chairman of the Investigations and Oversight Subcommittee, House Committee on Science, Space, and Technology, GAO reviewed the program to identify the factors that led to the cancellation of the CRAF project and the prospects for continuation of the Cassini project.

  7. Outward to the Beginning: the CRAF and Cassini Missions of the Mariner Mark 2 Program

    NASA Technical Reports Server (NTRS)

    1988-01-01

    Two successive journeys will soon offer a perspective on the origin of the solar system and perhaps provide clues on the origin of life as well. The missions, the Comet Rendezvous Asteroid Flyby (CRAF) and Cassini (the Saturn orbiter/Titan probe), combine to form the first initiative of the Mariner Mark 2 program, a series of planetary missions whose common objective is to explore primitive bodies and the outer solar system, toward the ultimate goal of understanding the nature of our origins. Cassini and CRAF are exciting planetary missions. The objectives that they share, the region of the solar system in which comets, asteroids, and the Saturnian system have evolved and now reside, and the spacecraft that will carry both sets of experiments to their targets in the outer solar system are described.

  8. Impaired neuronal maturation of hippocampal neural progenitor cells in mice lacking CRAF.

    PubMed

    Pfeiffer, Verena; Götz, Rudolf; Camarero, Guadelupe; Heinsen, Helmut; Blum, Robert; Rapp, Ulf Rüdiger

    2018-01-01

    RAF kinases are major constituents of the mitogen activated signaling pathway, regulating cell proliferation, differentiation and cell survival of many cell types, including neurons. In mammals, the family of RAF proteins consists of three members, ARAF, BRAF, and CRAF. Ablation of CRAF kinase in inbred mouse strains causes major developmental defects during fetal growth and embryonic or perinatal lethality. Heterozygous germline mutations in CRAF result in Noonan syndrome, which is characterized by neurocognitive impairment that may involve hippocampal physiology. The role of CRAF signaling during hippocampal development and generation of new postnatal hippocampal granule neurons has not been examined and may provide novel insight into the cause of hippocampal dysfunction in Noonan syndrome. In this study, by crossing CRAF-deficiency to CD-1 outbred mice, a CRAF mouse model was established which enabled us to investigate the interplay of neural progenitor proliferation and postmitotic differentiation during adult neurogenesis in the hippocampus. Albeit the general morphology of the hippocampus was unchanged, CRAF-deficient mice displayed smaller granule cell layer (GCL) volume at postnatal day 30 (P30). In CRAF-deficient mice a substantial number of abnormal, chromophilic, fast dividing cells were found in the subgranular zone (SGZ) and hilus of the dentate gyrus (DG), indicating that CRAF signaling contributes to hippocampal neural progenitor proliferation. CRAF-deficient neural progenitor cells showed an increased cell death rate and reduced neuronal maturation. These results indicate that CRAF function affects postmitotic neural cell differentiation and points to a critical role of CRAF-dependent growth factor signaling pathway in the postmitotic development of adult-born neurons.

  9. Impaired neuronal maturation of hippocampal neural progenitor cells in mice lacking CRAF

    PubMed Central

    Götz, Rudolf; Camarero, Guadelupe; Heinsen, Helmut; Blum, Robert; Rapp, Ulf Rüdiger

    2018-01-01

    RAF kinases are major constituents of the mitogen activated signaling pathway, regulating cell proliferation, differentiation and cell survival of many cell types, including neurons. In mammals, the family of RAF proteins consists of three members, ARAF, BRAF, and CRAF. Ablation of CRAF kinase in inbred mouse strains causes major developmental defects during fetal growth and embryonic or perinatal lethality. Heterozygous germline mutations in CRAF result in Noonan syndrome, which is characterized by neurocognitive impairment that may involve hippocampal physiology. The role of CRAF signaling during hippocampal development and generation of new postnatal hippocampal granule neurons has not been examined and may provide novel insight into the cause of hippocampal dysfunction in Noonan syndrome. In this study, by crossing CRAF-deficiency to CD-1 outbred mice, a CRAF mouse model was established which enabled us to investigate the interplay of neural progenitor proliferation and postmitotic differentiation during adult neurogenesis in the hippocampus. Albeit the general morphology of the hippocampus was unchanged, CRAF-deficient mice displayed smaller granule cell layer (GCL) volume at postnatal day 30 (P30). In CRAF-deficient mice a substantial number of abnormal, chromophilic, fast dividing cells were found in the subgranular zone (SGZ) and hilus of the dentate gyrus (DG), indicating that CRAF signaling contributes to hippocampal neural progenitor proliferation. CRAF-deficient neural progenitor cells showed an increased cell death rate and reduced neuronal maturation. These results indicate that CRAF function affects postmitotic neural cell differentiation and points to a critical role of CRAF-dependent growth factor signaling pathway in the postmitotic development of adult-born neurons. PMID:29590115

  10. MEK-1 Activates C-Raf Through a Ras-Independent Mechanism

    PubMed Central

    Leicht, Deborah T.; Balan, Vitaly; Zhu, Jun; Kaplun, Alexander; Bronisz, Agnieszka; Rana, Ajay; Tzivion, Guri

    2013-01-01

    C-Raf is a member of the Ras-Raf-MEK-ERK mitogen-activated protein kinase (MAPK) signaling pathway that plays key roles in diverse physiological processes and is upregulated in many human cancers. C-Raf activation involves binding to Ras, increased phosphorylation and interactions with co-factors. Here, we describe a Ras-independent in vivo pathway for C-Raf activation by its downstream target MEK. Using 32P-metabolic labeling and 2D-phosphopeptide mapping experiments, we show that MEK increases C-Raf phosphorylation by up-to 10-fold. This increase was associated with C-Raf kinase activation, matching the activity seen with growth factor stimulation. Consequently, coexpression of wildtype C-Raf and MEK was sufficient for full and constitutive activation of ERK. Notably, the ability of MEK to activate C-Raf was completely Ras independent, since mutants impaired in Ras binding that are irresponsive to growth factors or Ras were fully activated by MEK. The ability of MEK to activate C-Raf was only partially dependent on MEK kinase activity but required MEK binding to C-Raf, suggesting that the binding results in a conformational change that increases C-Raf susceptibility to phosphorylation and activation or in the stabilization of the phosphorylated-active form. These findings propose a novel Ras-independent mechanism for activating C-Raf and the MAPK pathway without the need for mutations in the pathway. This mechanism could be of significance in pathological conditions or cancers overexpressing C-Raf and MEK or in conditions where C-Raf-MEK interaction is enhanced due to the downregulation of RKIP and MST2. PMID:23360980

  11. C-RAF function at the genome-wide transcriptome level: A systematic view.

    PubMed

    Huang, Ying; Zhang, Xin-Yu; An, Su; Yang, Yang; Liu, Ying; Hao, Qian; Guo, Xiao-Xi; Xu, Tian-Rui

    2018-05-20

    C-RAF was the first member of the RAF kinase family to be discovered. Since its discovery, C-RAF has been found to regulate many fundamental cell processes, such as cell proliferation, cell death, and metabolism. However, the majority of these functions are achieved through interactions with different proteins; the genes regulated by C-RAF in its active or inactive state remain unclear. In the work, we used RNA-seq analysis to study the global transcriptomes of C-RAF bearing or C-RAF knockout cells in quiescent or EGF activated states. We identified 3353 genes that are promoted or suppressed by C-RAF. Gene ontology and Kyoto Encyclopedia of Genes and Genomes analyses revealed that these genes are involved in drug addiction, cardiomyopathy, autoimmunity, and regulation of cell metabolism. Our results provide a panoramic view of C-RAF function, including known and novel functions, and have revealed potential targets for elucidating the role of C-RAF. Copyright © 2018 Elsevier B.V. All rights reserved.

  12. Activation of c-Raf-1 kinase signal transduction pathway in alpha(7) integrin-deficient mice.

    PubMed

    Saher, G; Hildt, E

    1999-09-24

    Integrin alpha(7)-deficient mice develop a novel form of muscular dystrophy. Here we report that deficiency of alpha(7) integrin causes an activation of the c-Raf-1/mitogen-activated protein (MAP) 2 kinase signal transduction pathway in muscle cells. The observed activation of c-Raf-1/MAP2 kinases is a specific effect, because the alpha(7) integrin deficiency does not cause unspecific stress as determined by measurement of the Hsp72/73 level and activity of the JNK2 kinase. Because an increased level of activated FAK was found in muscle of alpha(7) integrin-deficient mice, the activation of c-Raf-1 kinase is triggered most likely by an integrin-dependent pathway. In accordance with this, in the integrin alpha(7)-deficient mice, part of the integrin beta(1D) variant in muscle is replaced by the beta(1A) variant, which permits the FAK activation. A recent report describes that integrin activity can be down-modulated by the c-Raf-1/MAP2 kinase pathway. Specific activation of the c-Raf-1/MAP2 kinases by cell-permeable peptides in skeletal muscle of rabbits causes degeneration of muscle fibers. Therefore, we conclude that in alpha(7) integrin-deficient mice, the continuous activation of c-Raf-1 kinase causes a permanent reduction of integrin activity diminishing integrin-dependent cell-matrix interactions and thereby contributing to the development of the dystrophic phenotype.

  13. c-Raf in KRas Mutant Cancers: A Moving Target.

    PubMed

    McCormick, Frank

    2018-02-12

    Therapies for KRas cancers remain a major clinical need. In the current issue of Cancer Cell, Sanclemente and coworkers in Mariano Barbacid's group validate c-Raf as a prime target for these cancers. c-Raf ablation caused regression of advanced KRas G12V /Trp53 tumors, without obvious systemic toxicity and without affecting MAPK signaling. Copyright © 2018 Elsevier Inc. All rights reserved.

  14. The Tumor Suppressor DiRas3 Forms a Complex with H-Ras and C-RAF Proteins and Regulates Localization, Dimerization, and Kinase Activity of C-RAF*

    PubMed Central

    Baljuls, Angela; Beck, Matthias; Oenel, Ayla; Robubi, Armin; Kroschewski, Ruth; Hekman, Mirko; Rudel, Thomas; Rapp, Ulf R.

    2012-01-01

    The maternally imprinted Ras-related tumor suppressor gene DiRas3 is lost or down-regulated in more than 60% of ovarian and breast cancers. The anti-tumorigenic effect of DiRas3 is achieved through several mechanisms, including inhibition of cell proliferation, motility, and invasion, as well as induction of apoptosis and autophagy. Re-expression of DiRas3 in cancer cells interferes with the signaling through Ras/MAPK and PI3K. Despite intensive research, the mode of interference of DiRas3 with the Ras/RAF/MEK/ERK signal transduction is still a matter of speculation. In this study, we show that DiRas3 associates with the H-Ras oncogene and that activation of H-Ras enforces this interaction. Furthermore, while associated with DiRas3, H-Ras is able to bind to its effector protein C-RAF. The resulting multimeric complex consisting of DiRas3, C-RAF, and active H-Ras is more stable than the two protein complexes H-Ras·C-RAF or H-Ras·DiRas3, respectively. The consequence of this complex formation is a DiRas3-mediated recruitment and anchorage of C-RAF to components of the membrane skeleton, suppression of C-RAF/B-RAF heterodimerization, and inhibition of C-RAF kinase activity. PMID:22605333

  15. Novel Cancer Therapeutics with Allosteric Modulation of the Mitochondrial C-Raf-DAPK Complex by Raf Inhibitor Combination Therapy.

    PubMed

    Tsai, Yi-Ta; Chuang, Mei-Jen; Tang, Shou-Hung; Wu, Sheng-Tang; Chen, Yu-Chi; Sun, Guang-Huan; Hsiao, Pei-Wen; Huang, Shih-Ming; Lee, Hwei-Jen; Yu, Cheng-Ping; Ho, Jar-Yi; Lin, Hui-Kuan; Chen, Ming-Rong; Lin, Chung-Chih; Chang, Sun-Yran; Lin, Victor C; Yu, Dah-Shyong; Cha, Tai-Lung

    2015-09-01

    Mitochondria are the powerhouses of cells. Mitochondrial C-Raf is a potential cancer therapeutic target, as it regulates mitochondrial function and is localized to the mitochondria by its N-terminal domain. However, Raf inhibitor monotherapy can induce S338 phosphorylation of C-Raf (pC-Raf(S338)) and impede therapy. This study identified the interaction of C-Raf with S308 phosphorylated DAPK (pDAPK(S308)), which together became colocalized in the mitochondria to facilitate mitochondrial remodeling. Combined use of the Raf inhibitors sorafenib and GW5074 had synergistic anticancer effects in vitro and in vivo, but targeted mitochondrial function, rather than the canonical Raf signaling pathway. C-Raf depletion in knockout MEF(C-Raf-/-) or siRNA knockdown ACHN renal cancer cells abrogated the cytotoxicity of combination therapy. Crystal structure simulation showed that GW5074 bound to C-Raf and induced a C-Raf conformational change that enhanced sorafenib-binding affinity. In the presence of pDAPK(S308), this drug-target interaction compromised the mitochondrial targeting effect of the N-terminal domain of C-Raf, which induced two-hit damages to cancer cells. First, combination therapy facilitated pC-Raf(S338) and pDAPK(S308) translocation from mitochondria to cytoplasm, leading to mitochondrial dysfunction and reactive oxygen species (ROS) generation. Second, ROS facilitated PP2A-mediated dephosphorylation of pDAPK(S308) to DAPK. PP2A then dissociated from the C-Raf-DAPK complex and induced profound cancer cell death. Increased pDAPK(S308) modification was also observed in renal cancer tissues, which correlated with poor disease-free survival and poor overall survival in renal cancer patients. Besides mediating the anticancer effect, pDAPK(S308) may serve as a predictive biomarker for Raf inhibitors combination therapy, suggesting an ideal preclinical model that is worthy of clinical translation. ©2015 American Association for Cancer Research.

  16. Cometary Matter Analyser (COMA/CRAF)

    NASA Technical Reports Server (NTRS)

    Buechler, K.; Igenbergs, E.; Klein, J. W.; Krueger, F. R.; Kuczera, H.; Morfill, G.; Palme, H.; Roessler, K.; Weishaupt, U.; Zerrull, R.; hide

    1994-01-01

    This project was part of an international program under which the chemical composition of cometary dust particles was to be measured 'in situ' during a rendezvous and flyby mission of a Mariner Mark 2 space probe and a comet (depending on the time of launch). Two necessary tasks, preliminary hardware development and interface definition, have been completed within the projects submitted for approval. As a result a model close to the flight configuration has been created, which was to be made available to the flight hardware contractor and his purposes. The Comet Rendezvous and Asteroid Flyby (CRAF) mission was abandoned after joint resolution adopted by NASA and the Federal Ministry for Research and Technology in 1992. Since an instrument like CoMA is an important contribution both to future cometary rendezvous missions, such as ROSETTA, as well as for accompanying laboratory activities, this project was terminated in a 'qualified conclusion'. In the process, components suitable for the laboratory developed from the preliminary units were produced and put into operation.

  17. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Guo, Wenjing; Hao, Baixia; Wang, Qian

    Extracellular signal-regulated kinases (ERKs) have been implicated to be dispensable for self-renewal of mouse embryonic stem (ES) cells, and simultaneous inhibition of both ERK signaling and glycogen synthase kinase 3 (GSK3) not only allows mouse ES cells to self-renew independent of extracellular stimuli but also enables more efficient derivation of naïve ES cells from mouse and rat strains. Interestingly, some ERKs stay active in mouse ES cells which are maintained in regular medium containing leukemia inhibitory factor (LIF) and bone morphogenetic protein (BMP). Yet, the upstream signaling for ERK activation and their roles in mouse ES cells, other than promotingmore » or priming differentiation, have not been determined. Here we found that mouse ES cells express three forms of Raf kinases, A-Raf, B-Raf, and C-Raf. Knocking-down each single Raf member failed to affect the sustained ERK activity, neither did A-Raf and B-Raf double knockdown or B-Raf and C-Raf double knockdown change it in ES cells. Interestingly, B-Raf and C-Raf double knockdown, not A-Raf and B-Raf knockdown, inhibited the maximal ERK activation induced by LIF, concomitant with the slower growth of ES cells. On the other hand, A-Raf, B-Raf, and C-Raf triple knockdown markedly inhibited both the maximal and sustained ERK activity in ES cells. Moreover, Raf triple knockdown, similar to the treatment of U-0126, an MEK inhibitor, significantly inhibited the survival and proliferation of ES cells, thereby compromising the colony propagation of mouse ES cells. In summary, our data demonstrate that all three Raf members are required for ERK activation in mouse ES cells and are involved in growth and survival of mouse ES cells. - Highlights: ●Mouse ES (mES) cells express all three Raf members, A-Raf, B-Raf, and C-Raf. ●Leukemia inhibitory factor (LIF) temporally activates ERKs in mES cells. ●B-Raf and C-Raf are required for LIF-induced maximal ERKs activity in mES cells. ●All Raf members are required for LIF-induced sustained ERK activity in mES cells. ●All Raf members are required the survival and proliferation of mES cells.« less

  18. 77 FR 14482 - Petroleum Reduction and Alternative Fuel Consumption Requirements for Federal Fleets

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-12

    ... agencies to use this methodology to determine fleet inventory targets and to prepare fleet management plans.... Department of Energy, Office of Energy Efficiency and Renewable Energy, Federal Energy Management Program (EE... DOE receives will be made available on the Federal Energy Management Program's Federal Fleet...

  19. 40 CFR 88.305-94 - Clean-fuel fleet vehicle labeling requirements for heavy-duty vehicles.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 21 2012-07-01 2012-07-01 false Clean-fuel fleet vehicle labeling requirements for heavy-duty vehicles. 88.305-94 Section 88.305-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CLEAN-FUEL VEHICLES Clean-Fuel Fleet Program § 88.305-94 Clean-fuel fleet vehicle labeling...

  20. 40 CFR 88.305-94 - Clean-fuel fleet vehicle labeling requirements for heavy-duty vehicles.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 21 2013-07-01 2013-07-01 false Clean-fuel fleet vehicle labeling requirements for heavy-duty vehicles. 88.305-94 Section 88.305-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CLEAN-FUEL VEHICLES Clean-Fuel Fleet Program § 88.305-94 Clean-fuel fleet vehicle labeling...

  1. 40 CFR 88.305-94 - Clean-fuel fleet vehicle labeling requirements for heavy-duty vehicles.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 20 2014-07-01 2013-07-01 true Clean-fuel fleet vehicle labeling requirements for heavy-duty vehicles. 88.305-94 Section 88.305-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CLEAN-FUEL VEHICLES Clean-Fuel Fleet Program § 88.305-94 Clean-fuel fleet vehicle labeling...

  2. 40 CFR 88.305-94 - Clean-fuel fleet vehicle labeling requirements for heavy-duty vehicles.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 20 2011-07-01 2011-07-01 false Clean-fuel fleet vehicle labeling requirements for heavy-duty vehicles. 88.305-94 Section 88.305-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CLEAN-FUEL VEHICLES Clean-Fuel Fleet Program § 88.305-94 Clean-fuel fleet vehicle labeling...

  3. The effect of arrestin conformation on the recruitment of c-Raf1, MEK1, and ERK1/2 activation.

    PubMed

    Coffa, Sergio; Breitman, Maya; Hanson, Susan M; Callaway, Kari; Kook, Seunghyi; Dalby, Kevin N; Gurevich, Vsevolod V

    2011-01-01

    Arrestins are multifunctional signaling adaptors originally discovered as proteins that "arrest" G protein activation by G protein-coupled receptors (GPCRs). Recently GPCR complexes with arrestins have been proposed to activate G protein-independent signaling pathways. In particular, arrestin-dependent activation of extracellular signal-regulated kinase 1/2 (ERK1/2) has been demonstrated. Here we have performed in vitro binding assays with pure proteins to demonstrate for the first time that ERK2 directly binds free arrestin-2 and -3, as well as receptor-associated arrestins-1, -2, and -3. In addition, we showed that in COS-7 cells arrestin-2 and -3 association with β(2)-adrenergic receptor (β2AR) significantly enhanced ERK2 binding, but showed little effect on arrestin interactions with the upstream kinases c-Raf1 and MEK1. Arrestins exist in three conformational states: free, receptor-bound, and microtubule-associated. Using conformationally biased arrestin mutants we found that ERK2 preferentially binds two of these: the "constitutively inactive" arrestin-Δ7 mimicking microtubule-bound state and arrestin-3A, a mimic of the receptor-bound conformation. Both rescue arrestin-mediated ERK1/2/activation in arrestin-2/3 double knockout fibroblasts. We also found that arrestin-2-c-Raf1 interaction is enhanced by receptor binding, whereas arrestin-3-c-Raf1 interaction is not.

  4. The Effect of Arrestin Conformation on the Recruitment of c-Raf1, MEK1, and ERK1/2 Activation

    PubMed Central

    Coffa, Sergio; Breitman, Maya; Hanson, Susan M.; Callaway, Kari; Kook, Seunghyi; Dalby, Kevin N.; Gurevich, Vsevolod V.

    2011-01-01

    Arrestins are multifunctional signaling adaptors originally discovered as proteins that “arrest” G protein activation by G protein-coupled receptors (GPCRs). Recently GPCR complexes with arrestins have been proposed to activate G protein-independent signaling pathways. In particular, arrestin-dependent activation of extracellular signal-regulated kinase 1/2 (ERK1/2) has been demonstrated. Here we have performed in vitro binding assays with pure proteins to demonstrate for the first time that ERK2 directly binds free arrestin-2 and -3, as well as receptor-associated arrestins-1, -2, and -3. In addition, we showed that in COS-7 cells arrestin-2 and -3 association with β2-adrenergic receptor (β2AR) significantly enhanced ERK2 binding, but showed little effect on arrestin interactions with the upstream kinases c-Raf1 and MEK1. Arrestins exist in three conformational states: free, receptor-bound, and microtubule-associated. Using conformationally biased arrestin mutants we found that ERK2 preferentially binds two of these: the “constitutively inactive” arrestin-Δ7 mimicking microtubule-bound state and arrestin-3A, a mimic of the receptor-bound conformation. Both rescue arrestin-mediated ERK1/2/activation in arrestin-2/3 double knockout fibroblasts. We also found that arrestin-2-c-Raf1 interaction is enhanced by receptor binding, whereas arrestin-3-c-Raf1 interaction is not. PMID:22174878

  5. The Retrofit Puzzle Extended: Optimal Fleet Owner Behavior over Multiple Time Periods

    DOT National Transportation Integrated Search

    2009-08-04

    In "The Retrofit Puzzle: Optimal Fleet Owner Behavior in the Context of Diesel Retrofit Incentive Programs" (1) an integer program was developed to model profit-maximizing diesel fleet owner behavior when selecting pollution reduction retrofits. Flee...

  6. The Impact of Long-Run CRAF Activation Risk on International Routes

    DTIC Science & Technology

    2011-06-01

    CRAF Stage II activations. United Airlines’ Los Angeles ( LAX ) to Tokyo, Japan (NRT) route scored a low .236, while the country risk for United in...0.5969 3.0173 16.5955 CO EWR MUC 0.0038 0.0213 3.0173 16.5955 UA LAX NRT 0.0333 0.2363 4.7173 28.4942 Route Risk Score Ranges - Low: 0 - .5...International Airport LAX – Los Angles International Airport ORD – Chicago O’Hare International Airport SFO – San Francisco International Airport

  7. The Capability Portfolio Analysis Tool (CPAT): A Mixed Integer Linear Programming Formulation for Fleet Modernization Analysis (Version 2.0.2).

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Waddell, Lucas; Muldoon, Frank; Henry, Stephen Michael

    In order to effectively plan the management and modernization of their large and diverse fleets of vehicles, Program Executive Office Ground Combat Systems (PEO GCS) and Program Executive Office Combat Support and Combat Service Support (PEO CS&CSS) commis- sioned the development of a large-scale portfolio planning optimization tool. This software, the Capability Portfolio Analysis Tool (CPAT), creates a detailed schedule that optimally prioritizes the modernization or replacement of vehicles within the fleet - respecting numerous business rules associated with fleet structure, budgets, industrial base, research and testing, etc., while maximizing overall fleet performance through time. This paper contains a thor-more » ough documentation of the terminology, parameters, variables, and constraints that comprise the fleet management mixed integer linear programming (MILP) mathematical formulation. This paper, which is an update to the original CPAT formulation document published in 2015 (SAND2015-3487), covers the formulation of important new CPAT features.« less

  8. Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF.

    PubMed

    Hu, Jiancheng; Yu, Haiyang; Kornev, Alexandr P; Zhao, Jianping; Filbert, Erin L; Taylor, Susan S; Shaw, Andrey S

    2011-04-12

    Because mutations in RAS and BRAF represent the most common mutations found in human tumors, identification of inhibitors has been a major goal. Surprisingly, new oncogenic BRAF specific inhibitors inhibit cells transformed with mutated BRAF but paradoxically stimulate the growth of cells transformed with RAS. Here, we show that the mechanism for activation is via drug-induced dimer formation between CRAF and kinase suppressor of Ras (KSR)1. To understand the function of KSR1, we generated a KSR1 mutant that cannot bind ATP but stabilizes the closed, active conformation of KSR1. Molecular modeling suggested that the mutant stabilizes the two hydrophobic spines critical for the closed active conformation. We, therefore, could use the mutant to discriminate between the scaffold versus kinase functions of KSR1. The KSR1 mutant bound constitutively to RAF and mitogen-activated protein kinase kinase (MEK) but could not reconstitute activity suggesting that the catalytic activity of KSR1 is required for its function. Analogous mutations in BRAF and CRAF allowed us to test the generality of the model. The mutation induced changes consistent with the active, closed conformation of both kinases and confirmed that BRAF functions distinctly from CRAF in the MAP kinase pathway. Not only does this work suggest that KSR1 may function as a kinase, we anticipate that the mutation that we generated may be broadly applicable to stabilize the closed conformation of other kinases many of which may also form dimers.

  9. Effects of Butyltins (BTs) on Mitogen-Activated-Protein Kinase Kinase Kinase (MAP3K) and Ras Activity in Human Natural Killer Cells

    PubMed Central

    Celada, Lindsay J.; Whalen, Margaret M.

    2013-01-01

    Butyltins (BTs) contaminate the environment and are found in human blood. BTs, tributyltin (TBT) and dibutyltin (DBT), diminish the cytotoxic function and levels of key proteins of human natural killer (NK) cells. NK cells are an initial immune defense against tumors, virally-infected cells and antibody-coated cells and thus critical to human health. The signaling pathways that regulate NK cell functions include mitogen-activated protein kinases (MAPKs). Studies have shown that exposure to BTs leads to the activation of specific MAPKs and MAPK kinases (MAP2Ks) in human NK cells. MAP2K kinases (MAP3Ks) are upstream activators of MAP2Ks, which then activate MAPKs. The current study examined if BT-induced activation of MAP3Ks was responsible for MAP2K and thus, MAPK activation. This study examines the effects of TBT and DBT on the total levels of two MAP3Ks, c-Raf and ASK1, as well as activating and inhibitory phosphorylation sites on these MAP3Ks. In addition, the immediate upstream activator of c-Raf, Ras, was examined for BT-induced alterations. Our results show significant activation of the MAP3K, c-Raf, in human NK cells within 10 minutes of TBT exposure and the MAP3K, ASK1, after one hour exposures to TBT. In addition, our results suggest that both TBT and DBT are impacting the regulation of c-Raf. PMID:24038145

  10. Fleet Management | Climate Neutral Research Campuses | NREL

    Science.gov Websites

    Fleet Management Fleet Management Research campuses often own and operate vehicles to carry out Sample Project Related Links Fleet Management Options The goal of fleet management within climate action alternative fuel use. The U.S. Department of Energy (DOE) Federal Energy Management Program (FEMP) outlines

  11. Alternative Fleet Architecture Design

    DTIC Science & Technology

    2005-08-01

    Alternative Fleet Architecture Design Stuart E. Johnson and Arthur K. Cebrowski Center...2005 4. TITLE AND SUBTITLE Alternative Fleet Architecture Design 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d...these principles in mind. An alternative fleet architecture design and three examples of future fleet platform architectures are presented in this

  12. Electric vehicles look promising for use in utility fleets

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Minner, D.

    1984-06-01

    The Electric Vehicle Development Corp. (EVDV) expects EV fleets to find a market for urban driving, especially among service fleets, once mass production begins. Electric utilities joined to form EVDC in order to keep abreast of research developments and the results of demonstrations taking place in several cities, where driver acceptance in utility demonstration programs is high. Major auto makers still need persuasion to develop a commercial prototype. Marketing will focus on controlled fleets having the management skills and the motivation to make the program work.

  13. Tug fleet and ground operations schedules and controls. Volume 1: Executive summary

    NASA Technical Reports Server (NTRS)

    1975-01-01

    This study presents Tug Fleet and Ground Operations Schedules and Controls plan. This plan was developed and optimized out of a combination of individual Tug program phased subplans, special emphasis studies, contingency analyses and sensitivity analyses. The subplans cover the Tug program phases: (1) Tug operational, (2) Interim Upper Stage (IUS)/Tug fleet utilization, (3) and IUS/Tug payload integration, (4) Tug site activation, (5) IUS/Tug transition, (6) Tug acquisition. Resource requirements (facility, GSE, TSE, software, manpower, logistics) are provided in each subplan, as are appropriate Tug processing flows, active and total IUS and Tug fleet requirements, fleet management and Tug payload integration concepts, facility selection recommendations, site activation and IUS to Tug transition requirements. The impact of operational concepts on Tug acquisition is assessed and the impact of operating Tugs out of KSC and WTR is analyzed and presented showing WTR as a delta. Finally, cost estimates for fleet management and ground operations of the DDT&E and operational phases of the Tug program are given.

  14. Alternative Fuels Data Center

    Science.gov Websites

    Fuel-Efficient Green Fleets Policy and Fleet Management Program Development The Alabama Green Fleets Review Committee (Committee) established a Green Fleets Policy (Policy) outlining a procedure for managers must classify their vehicle inventory for compliance with the Policy and submit annual plans for

  15. The MAZ transcription factor is a downstream target of the oncoprotein Cyr61/CCN1 and promotes pancreatic cancer cell invasion via CRAF-ERK signaling.

    PubMed

    Maity, Gargi; Haque, Inamul; Ghosh, Arnab; Dhar, Gopal; Gupta, Vijayalaxmi; Sarkar, Sandipto; Azeem, Imaan; McGregor, Douglas; Choudhary, Abhishek; Campbell, Donald R; Kambhampati, Suman; Banerjee, Sushanta K; Banerjee, Snigdha

    2018-03-23

    Myc-associated zinc-finger protein (MAZ) is a transcription factor with dual roles in transcription initiation and termination. Deregulation of MAZ expression is associated with the progression of pancreatic ductal adenocarcinoma (PDAC). However, the mechanism of action of MAZ in PDAC progression is largely unknown. Here, we present evidence that MAZ mRNA expression and protein levels are increased in human PDAC cell lines, tissue samples, a subcutaneous tumor xenograft in a nude mouse model, and spontaneous cancer in the genetically engineered PDAC mouse model. We also found that MAZ is predominantly expressed in pancreatic cancer stem cells. Functional analysis indicated that MAZ depletion in PDAC cells inhibits invasive phenotypes such as the epithelial-to-mesenchymal transition, migration, invasion, and the sphere-forming ability of PDAC cells. Mechanistically, we detected no direct effects of MAZ on the expression of K-Ras mutants, but MAZ increased the activity of CRAF-ERK signaling, a downstream signaling target of K-Ras. The MAZ-induced activation of CRAF-ERK signaling was mediated via p21-activated protein kinase (PAK) and protein kinase B (AKT/PKB) signaling cascades and promoted PDAC cell invasiveness. Moreover, we found that the matricellular oncoprotein cysteine-rich angiogenic inducer 61 (Cyr61/CCN1) regulates MAZ expression via Notch-1-sonic hedgehog signaling in PDAC cells. We propose that Cyr61/CCN1-induced expression of MAZ promotes invasive phenotypes of PDAC cells not through direct K-Ras activation but instead through the activation of CRAF-ERK signaling. Collectively, these results highlight key molecular players in PDAC invasiveness and may help inform therapeutic strategies to improve clinical management and outcomes of PDAC.

  16. 77 FR 66577 - Fisheries Off West Coast States; Pacific Coast Groundfish Fishery; Trawl Rationalization Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-06

    ... Pacific Fishery Management Council's Web site at http://www.pcouncil.org/ . Background In January 2011... groundfish fishery's trawl fleet. The trawl rationalization program consists of an IFQ program for the shorebased trawl fleet (including whiting and non-whiting fisheries); and cooperative (coop) programs for the...

  17. State and Alternative Fuel Provider Fleets - Fleet Compliance Annual Report: Model Year 2015, Fiscal Year 2016

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    The U.S. Department of Energy (DOE) regulates covered state government and alternative fuel provider fleets, pursuant to the Energy Policy Act of 1992 (EPAct), as amended. Covered fleets may meet their EPAct requirements through one of two compliance methods: Standard Compliance or Alternative Compliance. For model year (MY) 2015, the compliance rate with this program for the more than 3011 reporting fleets was 100%. More than 294 fleets used Standard Compliance and exceeded their aggregate MY 2015 acquisition requirements by 8% through acquisitions alone. The seven covered fleets that used Alternative Compliance exceeded their aggregate MY 2015 petroleum use reductionmore » requirements by 46%.« less

  18. Report: EPA’s Fleet Management Program Needs Improvement

    EPA Pesticide Factsheets

    Report #15-P-0001, October 6, 2014. If oversight of the EPA’s fleet is not improved, the $6 million-per-year program could be ineffective and inefficient in supporting the agency’s mission and reporting data to the federal system.

  19. Fleet Feedback and Fleet Efficiency Metrics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Singer, Mark R

    The Marine Corps have 10 years of experience implementing a telematics program and several lessons to share with partner agencies. This presentation details results of a Marine Corps survey as well as methods of using telematics to promote fleet efficiency and optimize the vehicle acquisition process.

  20. National Clean Fleets Partnership (Fact Sheet)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    2012-01-01

    Provides an overview of Clean Cities National Clean Fleets Partnership (NCFP). The NCFP is open to large private-sector companies that have fleet operations in multiple states. Companies that join the partnership receive customized assistance to reduce petroleum use through increased efficiency and use of alternative fuels. This initiative provides fleets with specialized resources, expertise, and support to successfully incorporate alternative fuels and fuel-saving measures into their operations. The National Clean Fleets Partnership builds on the established success of DOE's Clean Cities program, which reduces petroleum consumption at the community level through a nationwide network of coalitions that work with localmore » stakeholders. Developed with input from fleet managers, industry representatives, and Clean Cities coordinators, the National Clean Fleets Partnership goes one step further by working with large private-sector fleets.« less

  1. School Bus Fleet Safety: Planning and Development.

    ERIC Educational Resources Information Center

    Bieber, Robert M.

    1984-01-01

    To ensure worker safety, fleet safety managers need professional staffs, good access to top management, and sufficient authority to discharge their duties. Safety programs should include careful driver hiring; training, including orientation, testing, and practice; comprehensive accident reporting; and cooperative compliance programs with…

  2. Alternative Fuels Data Center

    Science.gov Websites

    Fleet Grants The Texas Commission on Environmental Quality (TCEQ) administers the Texas Clean Fleet Program (TCFP) as part of the Texas Emissions Reduction Plan (TERP). TCFP encourages owners of fleets current application periods, see the TCEQ TERP website. (Reference Senate Bill 1731, 2017, Texas Statutes

  3. 76 FR 68381 - Approval and Promulgation of Air Quality Implementation Plans; Pennsylvania; Pennsylvania Clean...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-04

    ... period within which vehicle manufacturers could comply with the program's fleet average non-methane... year meets the specified phase-in requirements according to the fleet average non- methane hydrocarbon requirement for that year. The fleet average non- methane hydrocarbon emission limits become progressively...

  4. The comet rendezvous asteroid flyby mission to Comet Kopff - Getting there is half the fun

    NASA Technical Reports Server (NTRS)

    Sweetser, Theodore H.; Kiedron, Krystyna

    1990-01-01

    The goal of the Comet Rendezvous Asteroid Flyby mission (CRAF) is to fly 'outward to the beginning', to examine closely what are thought to be remnants of the origins of the solar system. In particular, the CRAF spacecraft will use a two-year delta-V-earth-gravity-assist (delta-V-EGA) trajectory to reach a rendezvous point near the aphelion of the Comet Kopff, flying by the asteroid 449 Hamburga on the way. This paper discusses the trajectory used to get to the comet. Topics covered include the launch period, possible additional asteroid flybys, the earth flyby, the Hamburga flyby, and the rendezvous with Comet Kopff.

  5. The PreS2 activator MHBst of hepatitis B virus activates c-raf-1/Erk2 signaling in transgenic mice

    PubMed Central

    Hildt, Eberhard; Munz, Barbara; Saher, Gesine; Reifenberg, Kurt; Hofschneider, Peter Hans

    2002-01-01

    The large hepatitis B virus (HBV) surface protein (LHBs) and C-terminally truncated middle size surface proteins (MHBst) form the family of the PreS2 activator proteins of HBV. Their transcriptional activator function is based on the cytoplasmic orientation of the PreS2 domain. MHBst activators are paradigmatic for this class of activators. Here we report that MHBst is protein kinase C (PKC)-dependently phosphorylated at Ser28. The integrity of the phosphorylation site is essential for the activator function. MHBst triggers PKC-dependent activation of c-Raf-1/Erk2 signaling that is a prerequisite for MHBst-dependent activation of AP-1 and NF-κB. To analyze the pathophysiological relevance of these data in vivo, transgenic mice were established that produce the PreS2 activator MHBst specifically in the liver. In these mice, a permanent PreS2-dependent specific activation of c-Raf-1/Erk2 signaling was observed, resulting in an increased hepatocyte proliferation rate. In transgenics older than 15 months, an increased incidence of liver tumors occurs. These data suggest that PreS2 activators LHBs and MHBst exert a tumor promoter-like function by activation of key enzymes of proliferation control. PMID:11847101

  6. The PreS2 activator MHBs(t) of hepatitis B virus activates c-raf-1/Erk2 signaling in transgenic mice.

    PubMed

    Hildt, Eberhard; Munz, Barbara; Saher, Gesine; Reifenberg, Kurt; Hofschneider, Peter Hans

    2002-02-15

    The large hepatitis B virus (HBV) surface protein (LHBs) and C-terminally truncated middle size surface proteins (MHBs(t)) form the family of the PreS2 activator proteins of HBV. Their transcriptional activator function is based on the cytoplasmic orientation of the PreS2 domain. MHBs(t) activators are paradigmatic for this class of activators. Here we report that MHBs(t) is protein kinase C (PKC)-dependently phosphorylated at Ser28. The integrity of the phosphorylation site is essential for the activator function. MHBs(t) triggers PKC-dependent activation of c-Raf-1/Erk2 signaling that is a prerequisite for MHBs(t)-dependent activation of AP-1 and NF-kappaB. To analyze the pathophysiological relevance of these data in vivo, transgenic mice were established that produce the PreS2 activator MHBs(t) specifically in the liver. In these mice, a permanent PreS2-dependent specific activation of c-Raf-1/Erk2 signaling was observed, resulting in an increased hepatocyte proliferation rate. In transgenics older than 15 months, an increased incidence of liver tumors occurs. These data suggest that PreS2 activators LHBs and MHBs(t) exert a tumor promoter-like function by activation of key enzymes of proliferation control.

  7. Tug fleet and ground operations schedules and controls. Volume 2: part 1

    NASA Technical Reports Server (NTRS)

    1975-01-01

    This Tug Fleet and Ground Operations Schedules and Controls Study addresses both ground operational data and technical requirements that span the Tug planning phase and operations phase. A similar study covering mission operations (by others) provides the complimentary flight operations details. The two studies provide the planning data requirements, resource allocation, and control milestones for supporting the requirements of the STS program. This Tug Fleet and Ground Operations Schedules and Controls Study incorporates the basic ground operations requirements and concepts provided by previous studies with the interrelationships of the planning, IUS transition, and Tug fleet operations phases. The interrelationships of these phases were studied as a system to optimize overall program benefits and minimize operational risk factors.

  8. NREL Document Profiles Natural Gas Fueling, Fleet Operation

    Science.gov Websites

    , Waste Management's LNG Truck Fleet Start-Up Experience, offers solid evidence that LNG-powered vehicles program from concept to start-up to present-day operation, describing the vehicle, engine and fueling . The document Waste Management's LNG Truck Fleet Start-Up Experience is one of a series of NREL

  9. Phase I study of liposome-encapsulated c-raf antisense oligodeoxyribonucleotide infusion in combination with radiation therapy in patients with advanced malignancies.

    PubMed

    Dritschilo, Anatoly; Huang, Chao H; Rudin, Charles M; Marshall, John; Collins, Brian; Dul, Jeanne L; Zhang, Chuanbo; Kumar, Deepak; Gokhale, Prafulla C; Ahmad, Ateeq; Ahmad, Imran; Sherman, Jeffrey W; Kasid, Usha N

    2006-02-15

    Raf proteins are key elements of growth-related cellular signaling pathways and are a component of cancer cell resistance to radiation therapy. Antisense oligonucleotides to c-raf-1 permit highly selective inhibition of the gene product and offer a strategy for sensitizing cancer cells to radiation therapy. In this dose escalation study, we evaluated the safety of combined liposomal formulation of raf antisense oligonucleotide (LErafAON) and radiation therapy in patients with advanced malignancies. Patients with advanced solid tumors were treated with LErafAON in a phase I dose escalation study while receiving palliative radiation therapy. Drug-related and radiation-related toxicities were monitored. Pharmacokinetics and expression of c-raf-1 mRNA and Raf-1 protein were determined in peripheral blood mononuclear cells. Seventeen patients with palliative indications for radiation therapy were entered into this study. Thirteen patients received daily infusions of LErafAON and four received twice-weekly infusions. Radiation therapy was delivered in daily 300-cGy fractions over 2 weeks. Patients tolerated radiation, and no unexpected radiation-related side effects were observed. Drug-related reactions (grade > or =2), such as back pain, chills, dyspnea, fatigue, fever, flushing, and hypertension, were observed in most patients and were managed by premedication with corticosteroids and antihistamines. Serious adverse events occurred in five patients, including acute infusion-related symptoms, abnormal liver function tests, hypoxia, dehydration, diarrhea, esophagitis, fever, hypokalemia, pharyngitis, and tachypnea. Twelve of 17 patients were evaluable for tumor response at completion of treatment; four showed partial response, four showed stable disease, and four experienced progressive disease. The intact rafAON was detected in plasma for 30 minutes to several hours. Six patients with partial response or stable disease were evaluable for c-raf-1 mRNA and/or Raf-1 protein expression. Inhibition of c-raf-1 mRNA was observed in three of five patients. Raf-1 protein was inhibited in four of five patients. This is the first report of the combined modality treatment using antisense oligonucleotides with radiation therapy in patients with advanced cancer. A dose of 2.0 mg/kg of LErafAON administered twice weekly is tolerated with premedication and does not enhance radiation toxicity in patients. The observation of dose-dependent, infusion-related reactions has led to further modification of the liposomal composition for use in future clinical trials.

  10. 78 FR 35090 - Agency Information Collection Activity Under OMB Review; Reports, Forms and Recordkeeping...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-11

    ... forwarded to the Office of Management and Budget (OMB) for review and approval. The nature of the... qualified vessels in the Maritime Security Program Fleet. Applications and amendments are used to select vessels for the fleet. Periodic reporting is used to monitor adherence of contractors to program...

  11. 76 FR 6182 - Reports, Forms and Recordkeeping Requirements; Agency Information Collection Activity Under OMB...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-03

    ... forwarded to the Office of Management and Budget (OMB) for review and approval. The nature of the... qualified vessels in the Maritime Security Program Fleet. Applications and amendments are used to select vessels for the fleet. Periodic reporting is used to monitor adherence of contractors to program...

  12. The CPAT 2.0.2 Domain Model - How CPAT 2.0.2 "Thinks" From an Analyst Perspective.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Waddell, Lucas; Muldoon, Frank; Melander, Darryl J.

    To help effectively plan the management and modernization of their large and diverse fleets of vehicles, the Program Executive Office Ground Combat Systems (PEO GCS) and the Program Executive Office Combat Support and Combat Service Support (PEO CS &CSS) commissioned the development of a large - scale portfolio planning optimization tool. This software, the Capability Portfolio Analysis Tool (CPAT), creates a detailed schedule that optimally prioritizes the modernization or replacement of vehicles within the fleet - respecting numerous business rules associated with fleet structure, budgets, industrial base, research and testing, etc., while maximizing overall fleet performance through time. This reportmore » contains a description of the organizational fleet structure and a thorough explanation of the business rules that the CPAT formulation follows involving performance, scheduling, production, and budgets. This report, which is an update to the original CPAT domain model published in 2015 (SAND2015 - 4009), covers important new CPAT features. This page intentionally left blank« less

  13. Materiel Acquisition Management of U.S. Army Attack Helicopters

    DTIC Science & Technology

    1989-06-02

    used to evaluate the existing helicopter program periodically in order to determine utility in reference to all evaluation criteria. Defintion of... mixed integer linear programming model, the Phoenix model has demonstrated the potential to assist in the analysis of strategic and operational issues in...Fleet Max i of Aircraft per Fleet Programmed Buys .. -- Technology Unit Production mix Retirement Start-up ROTIE Flying Hour Aviation Overheadl I Aviation

  14. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Two online resources help fleets evaluate the economic soundness of a compressed natural gas program. The National Renewable Energy Laboratory's (NREL's) Vehicle Infrastructure and Cash-Flow Evaluation (VICE 2.0) model and the accompanying report, Building a Business Case for Compressed Natural Gas in Fleet Applications, are uniquely designed for fleet managers considering an investment in CNG and can help ensure wise investment decisions about CNG vehicles and infrastructure.

  15. Telematics and Data Science: Informing Energy-Efficient Mobility: October 25, 2016 - October 31, 2017

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sears, Edward B; Daley, Ryan; Helm, Matthew

    The University of Connecticut (UCONN) is exploring the possibility of adding electric vehicles (EVs) - including battery electric vehicles (BEVs), plug-in hybrid electric vehicles (PHEVs), or both - to its vehicle fleet. This report presents results of the UCONN fleet EV Suitability pilot program and offers recommendations for transitioning fleet vehicles to EVs as well as implementing adequate charging infrastructure.

  16. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    This guidebook addresses the primary requirements of the Alternative Fuel Transportation Program to help state and alternative fuel provider fleets comply with the Energy Policy Act via the Standard Compliance option. It also addresses the topics that covered fleets ask about most frequently.

  17. Aliphatic acetogenin constituents of avocado fruits inhibit human oral cancer cell proliferation by targeting the EGFR/RAS/RAF/MEK/ERK1/2 pathway

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    D'Ambrosio, Steven M.; Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210; Han, Chunhua

    2011-06-10

    Highlights: {yields} The aliphatic acetogenins [(2S,4S)-2,4-dihydroxyheptadec-16-enyl acetate] (1) and [(2S,4S)-2,4-dihydroxyheptadec-16-ynyl acetate] (2) isolated from avocado fruit inhibit phosphorylation of c-RAF (Ser338) and ERK1/2 (Thr202/Tyr204). {yields} Aliphatic acetogenin 2, but not 1, prevents EGF-induced activation of EGFR (Tyr1173). {yields} Combination of both aliphatic acetogenins synergistically inhibits c-RAF (Ser338) and ERK1/2 (Thr202/Tyr204) phosphorylation and human oral cancer cell proliferation. {yields} The potential anticancer activity of avocado fruits is due to a combination of specific aliphatic acetogenins targeting two key components of the EGFR/RAS/RAF/MEK/ERK1/2 cancer pathway. {yields} Providing a double hit on a critical cancer pathway such as EGFR/RAS/RAF/MEK/ERK1/2 by phytochemicals like thosemore » found in avocado fruit could lead to more effective approach toward cancer prevention. -- Abstract: Avocado (Persea americana) fruits are consumed as part of the human diet and extracts have shown growth inhibitory effects in various types of human cancer cells, although the effectiveness of individual components and their underlying mechanism are poorly understood. Using activity-guided fractionation of the flesh of avocado fruits, a chloroform-soluble extract (D003) was identified that exhibited high efficacy towards premalignant and malignant human oral cancer cell lines. From this extract, two aliphatic acetogenins of previously known structure were isolated, compounds 1 [(2S,4S)-2,4-dihydroxyheptadec-16-enyl acetate] and 2 [(2S,4S)-2,4-dihydroxyheptadec-16-ynyl acetate]. In this study, we show for the first time that the growth inhibitory efficacy of this chloroform extract is due to blocking the phosphorylation of EGFR (Tyr1173), c-RAF (Ser338), and ERK1/2 (Thr202/Tyr204) in the EGFR/RAS/RAF/MEK/ERK1/2 cancer pathway. Compounds 1 and 2 both inhibited phosphorylation of c-RAF (Ser338) and ERK1/2 (Thr202/Tyr204). Compound 2, but not compound 1, prevented EGF-induced activation of the EGFR (Tyr1173). When compounds 1 and 2 were combined they synergistically inhibited c-RAF (Ser338) and ERK1/2 (Thr202/Tyr204) phosphorylation, and human oral cancer cell proliferation. The present data suggest that the potential anticancer activity of avocado fruits is due to a combination of specific aliphatic acetogenins that target two key components of the EGFR/RAS/RAF/MEK/ERK1/2 cancer pathway.« less

  18. Missouri Soybean Association Biodiesel Demonstration Project: Final Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ludwig, Dale; Hamilton, Jill

    The Missouri Soybean Association (MSA) and the National Biodiesel Board (NBB) partnered together to implement the MSA Biodiesel Demonstration project under a United States Department of Energy (DOE) grant. The goal of this project was to provide decision makers and fleet managers with information that could lead to the increased use of domestically produced renewable fuels and could reduce the harmful impacts of school bus diesel exhaust on children. This project was initiated in September 2004 and completed in April 2011. The project carried out a broad range of activities organized under four areas: 1. Petroleum and related industry educationmore » program for fuel suppliers; 2. Fleet evaluation program using B20 with a Missouri school district; 3. Outreach and awareness campaign for school district fleet managers; and 4. Support of ongoing B20 Fleet Evaluation Team (FET) data collection efforts with existing school districts. Technical support to the biodiesel industry was also provided through NBB’s Troubleshooting Hotline. The hotline program was established in 2008 to troubleshoot fuel quality issues and help facilitate smooth implementation of the RFS and is described in greater detail under Milestone A.1 - Promote Instruction and Guidance on Best Practices. As a result of this project’s efforts, MSA and NBB were able to successfully reach out to and support a broad spectrum of biodiesel users in Missouri and New England. The MSA Biodiesel Demonstration was funded through a FY2004 Renewable Energy Resources Congressional earmark. The initial focus of this project was to test and evaluate biodiesel blends coupled with diesel oxidation catalysts as an emissions reduction technology for school bus fleets in the United States. The project was designed to verify emissions reductions using Environmental Protection Agency (EPA) protocols, then document – with school bus fleet experience – the viability of utilizing B20 blends. The fleet experience was expected to support ongoing industry efforts to collect existing data and to increase awareness and knowledge among school district fleet managers. However, three years into the project, the original intent of the engine verification was no longer deemed by equipment manufacturers to be of sufficient economic interest to enter into a partnership. In response, MSA requested a project extension and re-scope to eliminate the aftermarket equipment verification and replace it with a petroleum education program. The revised project maintained four task areas with the following modifications. The first component was directed at increasing national compliance with newly initiated state level fuel blend mandates through a distributor education program. Component two was modified to eliminate the verification element and, instead, document operational data from biodiesel use in a district school bus fleet. Components three and four were unchanged and maintained their purpose of expanding upon the existing knowledge base of biodiesel use in school bus fleets.« less

  19. DOE Office of Scientific and Technical Information (OSTI.GOV)

    This annual report of the Alternative Fuel Transportation Program, which ensures compliance with DOE regulations covering state government and alternative fuel provider fleets pursuant to the Energy Policy Act of 1992 (EPAct), as amended, provides fleet compliance results for manufacturing year 2014 / fiscal year 2015.

  20. 75 FR 16229 - Urbanized Area Formula Program: Notice of Final Circular

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-31

    ... revision. A. Chapter I--Introduction and Background Chapter I of the revised circular is the introductory... comprehensive fleet age and condition statistics are necessary for FTA to estimate fleet condition on a national...

  1. A Model for Forecasting Enlisted Student IA Billet Requirements

    DTIC Science & Technology

    2016-03-01

    Professional Apprentice Career Track PCS Permanent Change of Station PG Paygrade PFY Previous Fiscal Year POM Program Objectives Memorandum RCN Rating...paygrade levels contribute to fleet manning issues. Rating Control Number ( RCN ) Fit measures fleet manning levels for each community. Excess manning in one...lower RCN Fit levels. Second, authorized billets in TFMMS serve as the primary input for generating Enlisted Programmed Authorizations (EPA

  2. 10 CFR 490.200 - Purpose and scope.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false Purpose and scope. 490.200 Section 490.200 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State Fleet... duty motor vehicles acquired for State fleets be alternative fueled vehicles. ...

  3. 10 CFR 490.200 - Purpose and scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 3 2014-01-01 2014-01-01 false Purpose and scope. 490.200 Section 490.200 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State Fleet... duty motor vehicles acquired for State fleets be alternative fueled vehicles. ...

  4. 10 CFR 490.200 - Purpose and scope.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 3 2012-01-01 2012-01-01 false Purpose and scope. 490.200 Section 490.200 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State Fleet... duty motor vehicles acquired for State fleets be alternative fueled vehicles. ...

  5. 10 CFR 490.200 - Purpose and scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Purpose and scope. 490.200 Section 490.200 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State Fleet... duty motor vehicles acquired for State fleets be alternative fueled vehicles. ...

  6. 10 CFR 490.200 - Purpose and scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Purpose and scope. 490.200 Section 490.200 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State Fleet... duty motor vehicles acquired for State fleets be alternative fueled vehicles. ...

  7. From Concept to Design: Progress on the J-2X Upper Stage Engine for the Ares Launch Vehicles

    NASA Technical Reports Server (NTRS)

    Byrd, Thomas

    2008-01-01

    In accordance with national policy and NASA's Global Exploration Strategy, the Ares Projects Office is embarking on development of a new launch vehicle fleet to fulfill the national goals of replacing the space shuttle fleet, returning to the moon, and exploring farther destinations like Mars. These goals are shaped by the decision to retire the shuttle fleet by 2010, budgetary constraints, and the requirement to create a new fleet that is safer, more reliable, operationally more efficient than the shuttle fleet, and capable of supporting long-range exploration goals. The present architecture for the Constellation Program is the result of extensive trades during the Exploration Systems Architecture Study and subsequent refinement by the Ares Projects Office at Marshall Space Flight Center.

  8. Quantifying the Impact of Vehicle and Motor Fuel Provisions from the Energy Policy Act on the Sustainability and Resilience of U.S. Cities: Preprint

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Steward, Darlene; Sears, Ted

    The Energy Policy Act (EPAct) of 1992, with later amendments, was enacted with the goal of reducing U.S. petroleum consumption by building a core market for alternative fuels and vehicles. The U.S. Department of Energy manages three federal programs related to EPAct; the Sustainable Federal Fleets Program, the State and Alternative Fuel Provider Program, and Clean Cities. Federal agencies and State and Alternative Fuel Provider Fleets are required to submit annual reports that document their compliance with the legislation. Clean Cities is a voluntary program aimed at building partnerships and providing technical expertise to encourage cities to reduce petroleum usemore » in transportation. This study reviews the evolution of these three programs in relation to alternative fuel and vehicle markets and private sector adoption of alternative fueled vehicles to assess the impact of the programs on reduction in petroleum use and greenhouse gas emissions both within the regulated fleets and through development of alternative fuel and vehicle markets. The increased availability of alternative fuels and use of alternative fuels in regulated fleets is expected to improve cities' ability to respond to and quickly recover from both local disasters and short- and long-term regional or national fuel supply interruptions. Our analysis examines the benefits as well as potential drawbacks of alternative fuel use for the resiliency of U.S. cities.« less

  9. Managing railcar maintenance : a primer on practices and improvement opportunities for the U.S. transit industry.

    DOT National Transportation Integrated Search

    2013-09-01

    This report surveys the state-of-practice of transit railcar maintenance management and fleet management practices. It emphasizes a lifecycle management approach to fleet management. It also emphasizes the role of performance improvement programs and...

  10. Department of the Navy Amended FY 1992/FY 1993 Biennial Budget Estimates. R,D,T, and E Descriptive Summaries Submitted to Congress January 1992. Research, Development, Test and Evaluation, Navy

    DTIC Science & Technology

    1992-01-01

    counications between technology producer (Navy RDT&X community) and technology customer (Navy/MarLne Corps operating forces). Program technological...Additional programs as rwured by Fleet customer . 3. (U) 1t 1993 Planes Identify issues and provide link to RDT&3 community. Projects will vary according to...fleet customer requLrements. 4. (U) Program to Cmpletions This is a continuing program. D. (U) WORK pIRFORIpD l: iN-DOSE: NsWC Dahlgren, VA; AC

  11. Aberrant Expression of COT Is Related to Recurrence of Papillary Thyroid Cancer

    PubMed Central

    Lee, Jandee; Jeong, Seonhyang; Park, Jae Hyun; Lee, Cho Rok; Ku, Cheol Ryong; Kang, Sang-Wook; Jeong, Jong Ju; Nam, Kee-Hyun; Shin, Dong Yeob; Lee, Eun Jig; Chung, Woong Youn; Jo, Young Suk

    2015-01-01

    Abstract Aberrant expression of Cancer Osaka Thyroid Oncogene mitogen-activated protein kinase kinase kinase 8 (COT) (MAP3K8) is a driver of resistance to B-RAF inhibition. However, the de novo expression and clinical implications of COT in papillary thyroid cancer (PTC) have not been investigated. The aim of this study is to investigate the expression of A-, B-, C-RAF, and COT in PTC (n = 167) and analyze the clinical implications of aberrant expression of these genes. Quantitative polymerase chain reaction (qPCR) and immunohistochemical staining (IHC) were performed on primary thyroid cancers. Expression of COT was compared with clinicopathological characteristics including recurrence-free survival. Datasets from public repository (NCBI) were subjected to Gene Set Enrichment Analysis (GSEA). qPCR data showed that the relative mRNA expression of A-, B-, C-RAF and COT of PTC were higher than normal tissues (all P < 0.01). In addition, the expression of COT mRNA in PTC showed positive correlation with A- (r = 0.4083, P < 0.001), B- (r = 0.2773, P = 0.0003), and C-RAF (r = 0.5954, P < 0.001). The mRNA expressions of A-, B,- and C-RAF were also correlated with each other (all P < 0.001). In IHC, the staining intensities of B-RAF and COT were higher in PTC than in normal tissue (P < 0.001). Interestingly, moderate-to-strong staining intensities of B-RAF and COT were more frequent in B-RAFV600E-positive PTC (P < 0.001, P = 0.013, respectively). In addition, aberrant expression of COT was related to old age at initial diagnosis (P = 0.045) and higher recurrence rate (P = 0.025). In multivariate analysis, tumor recurrence was persistently associated with moderate-to-strong staining of COT after adjusting for age, sex, extrathyroidal extension, multifocality, T-stage, N-stage, TNM stage, and B-RAFV600E mutation (odds ratio, 4.662; 95% confidence interval 1.066 − 21.609; P = 0.045). Moreover, moderate-to-strong COT expression in PTC was associated with shorter recurrence-free survival (mean follow-up duration, 14.2 ± 4.1 years; P = 0.0403). GSEA indicated that gene sets related to B-RAF-RAS (P < 0.0001, false discovery rate [FDR] q-value = 0.000) and thyroid differentiation (P = 0.048, FDR q-value = 0.05) scores were enriched in lower COT expression group and gene sets such as T-cell receptor signaling pathway and Toll-like receptor signaling pathway are coordinately upregulated in higher COT expression group (both, P < 0.0001, FDR q-value = 0.000). Aberrant expression of A-, B-, and C-RAF, and COT is frequent in PTC; increased expression of COT is correlated with recurrence of PTC. PMID:25674762

  12. Aberrant expression of COT is related to recurrence of papillary thyroid cancer.

    PubMed

    Lee, Jandee; Jeong, Seonhyang; Park, Jae Hyun; Lee, Cho Rok; Ku, Cheol Ryong; Kang, Sang-Wook; Jeong, Jong Ju; Nam, Kee-Hyun; Shin, Dong Yeob; Lee, Eun Jig; Chung, Woong Youn; Jo, Young Suk

    2015-02-01

    Aberrant expression of Cancer Osaka Thyroid Oncogene mitogen-activated protein kinase kinase kinase 8 (COT) (MAP3K8) is a driver of resistance to B-RAF inhibition. However, the de novo expression and clinical implications of COT in papillary thyroid cancer (PTC) have not been investigated.The aim of this study is to investigate the expression of A-, B-, C-RAF, and COT in PTC (n = 167) and analyze the clinical implications of aberrant expression of these genes.Quantitative polymerase chain reaction (qPCR) and immunohistochemical staining (IHC) were performed on primary thyroid cancers. Expression of COT was compared with clinicopathological characteristics including recurrence-free survival. Datasets from public repository (NCBI) were subjected to Gene Set Enrichment Analysis (GSEA).qPCR data showed that the relative mRNA expression of A-, B-, C-RAF and COT of PTC were higher than normal tissues (all P < 0.01). In addition, the expression of COT mRNA in PTC showed positive correlation with A- (r = 0.4083, P < 0.001), B- (r = 0.2773, P = 0.0003), and C-RAF (r = 0.5954, P < 0.001). The mRNA expressions of A-, B,- and C-RAF were also correlated with each other (all P < 0.001). In IHC, the staining intensities of B-RAF and COT were higher in PTC than in normal tissue (P < 0.001). Interestingly, moderate-to-strong staining intensities of B-RAF and COT were more frequent in B-RAF-positive PTC (P < 0.001, P = 0.013, respectively). In addition, aberrant expression of COT was related to old age at initial diagnosis (P = 0.045) and higher recurrence rate (P = 0.025). In multivariate analysis, tumor recurrence was persistently associated with moderate-to-strong staining of COT after adjusting for age, sex, extrathyroidal extension, multifocality, T-stage, N-stage, TNM stage, and B-RAF mutation (odds ratio, 4.662; 95% confidence interval 1.066 - 21.609; P = 0.045). Moreover, moderate-to-strong COT expression in PTC was associated with shorter recurrence-free survival (mean follow-up duration, 14.2 ± 4.1 years; P = 0.0403). GSEA indicated that gene sets related to B-RAF-RAS (P < 0.0001, false discovery rate [FDR] q-value = 0.000) and thyroid differentiation (P = 0.048, FDR q-value = 0.05) scores were enriched in lower COT expression group and gene sets such as T-cell receptor signaling pathway and Toll-like receptor signaling pathway are coordinately upregulated in higher COT expression group (both, P < 0.0001, FDR q-value = 0.000).Aberrant expression of A-, B-, and C-RAF, and COT is frequent in PTC; increased expression of COT is correlated with recurrence of PTC.

  13. The CRAF/Cassini power subsystem - Preliminary design update

    NASA Technical Reports Server (NTRS)

    Atkins, Kenneth L.; Brisendine, Philip; Clark, Karla; Klein, John; Smith, Richard

    1991-01-01

    A chronology is provided of the rationale leading from the early Mariner spacecraft to the CRAF/Cassini Mariner Mark II power subsystem architecture. The display pathway began with a hybrid including a solar photovoltaic array, a radioisotope thermoelectric generator (RTG), and a battery supplying a power profile with a peak loading of about 300 W. The initial concept was to distribute power through a new solid-state, programmable switch controlled by an embedded microprocessor. As the overall mission, science, and project design matured, the power requirements increased. The design evolved from the hybrid to two RTG plus batteries to meet peak loadings of near 500 W in 1989. Later that year, circumstances led to abandonment of the distributed computer concept and a return to centralized control. Finally, as power requirements continued to grow, a third RTG was added to the design and the battery removed, with the return to the discharge-controller for transients during fault recovery procedures.

  14. Transportation Deployment Support | Transportation Research | NREL

    Science.gov Websites

    initiative complements the NPS Climate Friendly Parks program. Commercial Fleets Through the National Clean clearinghouse of medium- and heavy-duty commercial fleet vehicle operating data for optimizing vehicle improvement. Commercial Vehicle Technology Evaluations NREL conducts real-world evaluations of commercial

  15. A Coastal Risk Assessment Framework Tool to Identify Hotspots at the Regional Scale

    NASA Astrophysics Data System (ADS)

    Van Dongeren, A.; Viavattene, C.; Jimenez, J. A.; Ferreira, O.; Bolle, A.; Owen, D.; Priest, S.

    2016-02-01

    Extreme events in combination with an increasing population on the coast, future sea level rise and the deterioration of coastal defences can lead to catastrophic consequences for coastal communities and their activities. The Resilience-Increasing Strategies for Coasts - toolkit (RISC-KIT) FP7 EU project is producing a set of EU-coherent open-source and open-access tools in support of coastal managers and decision-makers. This paper presents one of these tools, the Coastal Risk Assessment Framework (CRAF) which assesses coastal risk at a regional scale to identify potential impact hotspots for more detailed assessment. Applying a suite of complex models at a full and detailed regional scale remains difficult and may not be efficient, therefore a 2-phase approach is adopted. CRAF Phase 1 is a screening process based on a coastal-index approach delimiting several hotspots in alongshore length by assessing the potential exposure for every kilometre along the coast. CRAF Phase 2 uses a suite of more complex modelling process (including X-beach 1D, inundation model, impact assessment and Multi-Criteria Analysis approach) to analyse and compare the risks between the aforementioned identified hotspots. Results of its application are compared on 3 European Case Studies, the Flemish highly protected low-lying coastal plain with important urbanization and harbors, a Portuguese coastal lagoon protected by a multi-inlet barrier system, the highly urbanized Catalonian coast with touristic activities at threat. The flexibility of the tool allows tailoring the comparative analysis to these different contexts and to adapt to the quality of resources and data available. Key lessons will be presented.

  16. Mobility Case Studies : Where Integrated Corridor Management Has Worked and Why

    DOT National Transportation Integrated Search

    2018-01-11

    Background: Modifying the task load of Emergency Medical Services (EMS) personnel may mitigate fatigue, sleep quality and fatigue related risks. A review of the literature addressing task load interventions may benefit EMS administrators as they craf...

  17. Sulfur dioxide inhibits vascular smooth muscle cell proliferation via suppressing the Erk/MAP kinase pathway mediated by cAMP/PKA signaling

    PubMed Central

    Liu, D; Huang, Y; Bu, D; Liu, A D; Holmberg, L; Jia, Y; Tang, C; Du, J; Jin, H

    2014-01-01

    The present study was designed to investigate the role of endogenous sulfur dioxide (SO2) in vascular smooth muscle cell (VSMC) proliferation, and explore the possible role of cross-talk between cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) and extracellular signal-regulated kinase (Erk)/mitogen-activated protein kinase (MAPK) pathways in this action. By cell counting, growth curve depict, flow cytometry and bromodeoxyuridine (BrdU) labeling assays, we found that SO2 inhibited VSMC proliferation by preventing cell cycle progression from G1 to S phase and by reducing DNA synthesis. SO2 synthase aspartate aminotransferase (AAT1 and AAT2) overexpression significantly inhibited serum-induced proliferating cell nuclear antigen (PCNA) protein expression in VSMCs, demonstrated by western blot analysis. Moreover, overexpression of AAT1 or AAT2 markedly reduced incorporation of BrdU in serum-treated VSMCs. By contrast, either AAT1 or AAT2 knockdown significantly exacerbated serum-stimulated VSMC proliferation. Thus, both exogenous- and endogenous-derived SO2 suppressed serum-induced VSMC proliferation. However, annexin V-propidium iodide (PI) staining and cell cycle analysis demonstrated that SO2 did not influence VSMC apoptosis in the serum-induced proliferation model. In a platelet-derived growth factor (PDGF)-BB-stimulated VSMC proliferation model, SO2 dephosphorylated the active sites of Erk1/2, MAPK kinase 1/2 and RAF proto-oncogene serine/threonine-protein kinase (c-Raf) induced by PDGF-BB. However, the inactivation of the three kinases of the Erk/MAPK pathway was not due to the separate interferences on them by SO2 simultaneously, but a consequence of the influence on the upstream activity of the c-Raf molecule. Hence, we examined the cAMP/PKA pathway, which could inhibit Erk/MAPK transduction in VSMCs. The results showed that SO2 could stimulate the cAMP/PKA pathway to block c-Raf activation, whereas the Ser259 site on c-Raf had an important role in SO2-induced suppression of Erk/MAPK pathway. The present study firstly demonstrated that SO2 exerted a negative regulation of VSMC proliferation via suppressing the Erk/MAPK pathway mediated by cAMP/PKA signaling. PMID:24853429

  18. Air Quality in Mexico City: Policies Implemented for its Improvement

    NASA Astrophysics Data System (ADS)

    Paramo, V.

    2007-12-01

    Ozone and suspended particles (PM) are two pollutants in the atmosphere of Mexico City Metropolitan Area (MCMA) that still exceed the recommended Mexican health standards. The other criteria pollutants very seldom exceed their corresponding standards. In 2006, the maximum ozone concentrations were above the health standard (0.11 ppm in 1 hour) during 59 percent of the days for an average of 2.2 hours and 130 points of the Air Quality Index (Índice Metropolitano de la Calidad del Aire - IMECA). In contrast, in 1991, 98 percent of the days exceeded the ozone health standard for an average of 6.6 hours and 200 IMECA points. With regards to PM10, in 2006, 80 percent of the sampled concentrations were below the health standard of 120 µg/m3 in 24 hours. However, the annual health standard of 50 µg/m3 is still exceeded. The air quality management in the MCMA is a difficult task due to several adverse factors. The main one is the large population that increased from nearly 15 million in 1992 to more than 18 million at present. As a result, the urban area grows in the adjoined municipalities of the State of Mexico. The vehicular fleet increases also to almost 4 million and the number of industrial facilities is at present 50,000. Consequently, the fuel consumption is very high. The daily energy consumption is estimated to be 44 million liters of equivalent of gasoline. Despite the fact that the air quality has improved in recent years, the related health standards are still exceeded and therefore it is necessary to continue applying the most cost-effective actions to improve the environment quality. Some actions that have contributed most to the reduction of pollutant emissions are the following: Continuous update of the inspection and maintenance program of the vehicular fleet; substitution of the catalytic converters at the end of their useful life; self-regulation of the diesel fleet; use of alternative fuels; update the No-Driving-Day program; establishment of more stringent emission levels of the gasoline fleet; update the detention of pollutant vehicles program; partial exemption of the inspection and maintenance program for cleaner and or highly efficient vehicles; substitution of 3,000 microbuses, 40,000 taxis and 1,200 buses; commissioning of the first Bus Rapid Transit system; implementation of a program for the emissions reduction for the 300 most polluted industrial facilities; and continuous update of the air quality environmental management programs. To continue improving the air quality in the MCMA, the environmental authorities will continue the implementation of the 2002-2010 Air Quality Improvement Program. In 2007 the Green Program was started, this includes those actions that have proven to be effective reduction of pollutant emissions and incorporates new actions for the reduction of local and global pollutant emissions. The most important of these new actions are: substitution of 9,500 microbuses; renewal of all the taxis fleet; commissioning of 10 Bus Rapid Transit lines; commissioning of Line 12 of the underground system; schedules and routes limitations to the cargo fleet; increase 5 percent the number of non-motorized trips (bicycling and walking); regulation of the private public transport passenger stops; requirement of private schools to provide school transport; regulation of non-occupied taxis in circulation; modifications to the circulation of 350 critical crossing points in the city; adoption of intelligent traffic lights systems; complete substitution of the local government vehicle's fleet; implement the inspection and maintenance of the cargo fleet; introduction of low- sulfur diesel, among other measures.

  19. ITS Technologies in Military Wheeled Tactical Vehicles: Status Quo and the Future

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Knee, H.E.

    2001-07-02

    The U.S. Army operates and maintains the largest trucking fleet in the United States. Its fleet consists of over 246,000 trucks, and it is responsible for buying and developing trucks for all branches of the armed forces. The Army's tactical wheeled vehicle fleet is the logistical backbone of the Army, and annually, the fleet logs about 823 million miles. The fleet consists of a number of types of vehicles. They include eight different families of trucks from the High Mobility Multi-Purpose Wheeled Vehicles to M900 series line haul tractors and special bodies. The average age of all the trucks withinmore » the Army fleet is 15 years, and very few have more than traditional driving instrumentation on-board. Over the past decade, the Department of Transportation's (DOT's) Intelligent Transportation Systems (ITS) Program has conducted research and deployment activities in a number of areas including in-vehicle systems, communication and telematics technologies. Many current model passenger vehicles have demonstrated the assimilation of these technologies to enhance safety and trip quality. Commercial vehicles are also demonstrating many new electronic devices that are assisting in making them safer and more efficient. Moreover, a plethora of new technologies are about to be introduced to drivers that promise greater safety, enhanced efficiency, congestion avoidance, fuel usage reduction, and enhanced trip quality. The U.S. Army has special needs with regard to fleet management, logistics, sustainability, reliability, survivability, and fuel consumption that goes beyond similar requirements within the private industry. In order to effectively apply emerging ITS technologies to the special needs of the U.S. Army, planning for the conduct of the Army's Vehicle Intelligence Program (AVIP) has now commenced. The AVIP will be focused on the conduct of research that: (1) will apply ITS technologies to the special needs of the Army, and (2) will conduct research for special needs wi th regard to vehicle control, driver assistance, integration of vehicle intelligence and robotic technologies, managing effectively the information flow to drivers, enhanced logistics capabilities and sustainability of the Army's fleet during battlefield conditions. This paper will highlight the special needs of the Army, briefly describe two programs, which are embracing ITS technologies to a limited extent, will outline the AVIP, and will provide some insight into future Army vehicle intelligence efforts.« less

  20. Management Training, Yes! Excellence?

    ERIC Educational Resources Information Center

    Davis, Gary E.

    1990-01-01

    Management training programs are a necessity for transportation supervisors. Basic and advanced training programs are available through associations for business officials and university fleet management training programs. (MLF)

  1. Proceedings of the Tri-Service Conference on Corrosion Held in Atlantic City, New Jersey on 17-19 October 1989

    DTIC Science & Technology

    1989-10-19

    installation. 4. Corrosion inhibiting compounds need to be applied in the final assealbly of models to all corrosion prone areas of the structure, e.g...Figure 12 shows an example of poor surface treatment of a previously repaired stringer area. Application of a corrosion inhibiting compound may have... compounds and a good corrosion control maintenance program. REFERENCE U. G. Goranson and M. Miller, "Aging Fleet - Aging Fleet Evaluation Program

  2. Lessons from cross-fleet/cross-airline observations - Evaluating the impact of CRM/LOFT training

    NASA Technical Reports Server (NTRS)

    Butler, Roy E.

    1991-01-01

    A review is presented of the crew resource management/line oriented flight training (CRM/LOFT) program to help determine the level of standardization across fleets and airlines in the critical area of evaluating crew behavior and performance. One of the goals of the project is to verify that check airmen and LOFT instructors within organizations are evaluating CRM issues consistently and that differences observed between fleets are not a function of idiosyncracies on the part of observers. Attention is given to the research tools for crew evaluation.

  3. Strategic Sealift: Part of the National Defense Reserve Fleet Is No Longer Needed

    DTIC Science & Technology

    1991-10-01

    would prevent MARAD from obtaining fair value for the scrapped ships and affect its ability to acquire newer ships for the Reserve Fleet. They also...Ship Exchange Program Offers are reviewed by a three-member MARAD vessel disposal committee to determine whether they reflect fair value for the

  4. Aliphatic acetogenin constituents of avocado fruits inhibit human oral cancer cell proliferation by targeting the EGFR/RAS/RAF/MEK/ERK1/2 pathway

    PubMed Central

    D’Ambrosio, Steven M.; Han, Chunhua; Pan, Li; Kinghorn, A. Douglas; Ding, Haiming

    2011-01-01

    Avocado (Persea americana) fruits are consumed as part of the human diet and extracts have shown growth inhibitory effects in various types of human cancer cells, although the effectiveness of individual components and their underlying mechanism are poorly understood. Using activity-guided fractionation of the flesh of avocado fruits, a chloroform-soluble extract (D003), was identified that exhibited high efficacy towards premalignant and malignant human oral cancer cell lines. From this extract, two aliphatic acetogenins of previously known structure were isolated, compounds 1 [(2S,4S)-2,4-dihydroxyheptadec-16-enyl acetate] and 2 [(2S,4S)-2,4-dihydroxyheptadec-16-ynyl acetate]. In this study, we show for the first time that the growth inhibitory efficacy of this chloroform extract is due to blocking the phosphorylation of EGFR (Tyr1173), c-RAF (Ser338), and ERK1/2 (Thr202/Tyr204) in the EGFR/RAS/RAF/MEK/ERK1/2 cancer pathway. Compound 1 and 2 both inhibited phosphorylation of c-RAF (Ser338) and ERK1/2 (Thr202/Tyr204). Compound 2, but not compound 1, prevented EGF-induced activation of EGFR (Tyr1173). When compounds 1 and 2 were combined they synergistically inhibited c-RAF (Ser338) and ERK1/2 (Thr202/Tyr204) phosphorylation, and human oral cancer cell proliferation. The present data suggest that the potential anticancer activity of avocado fruits is due to a combination of specific aliphatic acetogenins that target two key components of the EGFR/RAS/RAF/MEK/ERK1/2 cancer pathway. PMID:21596018

  5. Aliphatic acetogenin constituents of avocado fruits inhibit human oral cancer cell proliferation by targeting the EGFR/RAS/RAF/MEK/ERK1/2 pathway.

    PubMed

    D'Ambrosio, Steven M; Han, Chunhua; Pan, Li; Kinghorn, A Douglas; Ding, Haiming

    2011-06-10

    Avocado (Persea americana) fruits are consumed as part of the human diet and extracts have shown growth inhibitory effects in various types of human cancer cells, although the effectiveness of individual components and their underlying mechanism are poorly understood. Using activity-guided fractionation of the flesh of avocado fruits, a chloroform-soluble extract (D003) was identified that exhibited high efficacy towards premalignant and malignant human oral cancer cell lines. From this extract, two aliphatic acetogenins of previously known structure were isolated, compounds 1 [(2S,4S)-2,4-dihydroxyheptadec-16-enyl acetate] and 2 [(2S,4S)-2,4-dihydroxyheptadec-16-ynyl acetate]. In this study, we show for the first time that the growth inhibitory efficacy of this chloroform extract is due to blocking the phosphorylation of EGFR (Tyr1173), c-RAF (Ser338), and ERK1/2 (Thr202/Tyr204) in the EGFR/RAS/RAF/MEK/ERK1/2 cancer pathway. Compounds 1 and 2 both inhibited phosphorylation of c-RAF (Ser338) and ERK1/2 (Thr202/Tyr204). Compound 2, but not compound 1, prevented EGF-induced activation of the EGFR (Tyr1173). When compounds 1 and 2 were combined they synergistically inhibited c-RAF (Ser338) and ERK1/2 (Thr202/Tyr204) phosphorylation, and human oral cancer cell proliferation. The present data suggest that the potential anticancer activity of avocado fruits is due to a combination of specific aliphatic acetogenins that target two key components of the EGFR/RAS/RAF/MEK/ERK1/2 cancer pathway. Copyright © 2011 Elsevier Inc. All rights reserved.

  6. Hyperactive ERK and persistent mTOR signaling characterize vemurafenib resistance in papillary thyroid cancer cells.

    PubMed

    Hanly, Elyse K; Tuli, Neha Y; Bednarczyk, Robert B; Suriano, Robert; Geliebter, Jan; Moscatello, Augustine L; Darzynkiewicz, Zbigniew; Tiwari, Raj K

    2016-02-23

    Clinical studies evaluating targeted BRAFV600E inhibitors in advanced thyroid cancer patients are currently underway. Vemurafenib (BRAFV600E inhibitor) monotherapy has shown promising results thus far, although development of resistance is a clinical challenge. The objective of this study was to characterize development of resistance to BRAFV600E inhibition and to identify targets for effective combination therapy. We created a line of BCPAP papillary thyroid cancer cells resistant to vemurafenib by treating with increasing concentrations of the drug. The resistant BCPAP line was characterized and compared to its sensitive counterpart with respect to signaling molecules thought to be directly related to resistance. Expression and phosphorylation of several critical proteins were analyzed by Western blotting and dimerization was evaluated by immunoprecipitation. Resistance to vemurafenib in BCPAP appeared to be mediated by constitutive overexpression of phospho-ERK and by resistance to inhibition of both phospho-mTOR and phospho-S6 ribosomal protein after vemurafenib treatment. Expression of potential alternative signaling molecule, CRAF, was not increased in the resistant line, although formation of CRAF dimers appeared increased. Expression of membrane receptors HER2 and HER3 was greatly amplified in the resistant cancer cells. Papillary thyroid cancer cells were capable of overcoming targeted BRAFV600E inhibition by rewiring of cell signal pathways in response to prolonged vemurafenib therapy. Our study suggests that in vitro culture of cancer cells may be useful in assessing molecular resistance pathways. Potential therapies in advanced thyroid cancer patients may combine vemurafenib with inhibitors of CRAF, HER2/HER3, ERK, and/or mTOR to delay or abort development of resistance.

  7. 40 CFR 86.1862-04 - Maintenance of records and submittal of information relevant to compliance with fleet average NOX...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Control of Air Pollution From New and In-Use Light-Duty Vehicles, Light-Duty Trucks, and Complete Otto... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF... NOX value achieved; and (iv) All values used in calculating the fleet average NOX value achieved. (2...

  8. 40 CFR 86.1862-04 - Maintenance of records and submittal of information relevant to compliance with fleet average NOX...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Control of Air Pollution From New and In-Use Light-Duty Vehicles, Light-Duty Trucks, and Complete Otto... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF... NOX value achieved; and (iv) All values used in calculating the fleet average NOX value achieved. (2...

  9. 40 CFR 86.1862-04 - Maintenance of records and submittal of information relevant to compliance with fleet average NOX...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Control of Air Pollution From New and In-Use Light-Duty Vehicles, Light-Duty Trucks, and Complete Otto... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF... NOX value achieved; and (iv) All values used in calculating the fleet average NOX value achieved. (2...

  10. 40 CFR 86.1862-04 - Maintenance of records and submittal of information relevant to compliance with fleet average NOX...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Control of Air Pollution From New and In-Use Light-Duty Vehicles, Light-Duty Trucks, and Complete Otto... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF... NOX value achieved; and (iv) All values used in calculating the fleet average NOX value achieved. (2...

  11. Space transportation architecture: Reliability sensitivities

    NASA Technical Reports Server (NTRS)

    Williams, A. M.

    1992-01-01

    A sensitivity analysis is given of the benefits and drawbacks associated with a proposed Earth to orbit vehicle architecture. The architecture represents a fleet of six vehicles (two existing, four proposed) that would be responsible for performing various missions as mandated by NASA and the U.S. Air Force. Each vehicle has a prescribed flight rate per year for a period of 31 years. By exposing this fleet of vehicles to a probabilistic environment where the fleet experiences failures, downtimes, setbacks, etc., the analysis involves determining the resiliency and costs associated with the fleet of specific vehicle/subsystem reliabilities. The resources required were actual observed data on the failures and downtimes associated with existing vehicles, data based on engineering judgement for proposed vehicles, and the development of a sensitivity analysis program.

  12. Compressed/reconstructed test images for CRAF/Cassini

    NASA Technical Reports Server (NTRS)

    Dolinar, S.; Cheung, K.-M.; Onyszchuk, I.; Pollara, F.; Arnold, S.

    1991-01-01

    A set of compressed, then reconstructed, test images submitted to the Comet Rendezvous Asteroid Flyby (CRAF)/Cassini project is presented as part of its evaluation of near lossless high compression algorithms for representing image data. A total of seven test image files were provided by the project. The seven test images were compressed, then reconstructed with high quality (root mean square error of approximately one or two gray levels on an 8 bit gray scale), using discrete cosine transforms or Hadamard transforms and efficient entropy coders. The resulting compression ratios varied from about 2:1 to about 10:1, depending on the activity or randomness in the source image. This was accomplished without any special effort to optimize the quantizer or to introduce special postprocessing to filter the reconstruction errors. A more complete set of measurements, showing the relative performance of the compression algorithms over a wide range of compression ratios and reconstruction errors, shows that additional compression is possible at a small sacrifice in fidelity.

  13. Challenges and Opportunities of Air Quality Management in Mexico City

    NASA Astrophysics Data System (ADS)

    Paramo, V.

    2013-05-01

    The Mexico City Metropolitan Area (MCMA) is located in the central plateau of Mexico and is the capital of the country. Its natural characteristics present favorable conditions for air pollution formation and accumulation: mountains surrounding the city, frequent thermal inversions, high isolation all around the year and weak winds. To these natural conditions, a population of more than 20 million inhabitants, a fleet of 4.5 million vehicles and more than 4 thousands industries, make air quality management a real challenge for governments of the region. Intensive air quality improvement actions and programs began at the end of the 1980's and continued nowadays. Since then criteria air pollutants concentrations have decreased in such a way that currently most of pollutants meet the Mexican air quality standards, except for ozone and particulate matter. Applied measures comprised of fuel quality improvements, fuel replacements, regulations for combustion processes, closing of high polluting refineries and industries, regulations of emissions for new and on road vehicles, mandatory I/M programs for vehicles, circulation restrictions for vehicles (Day without car program), alert program for elevated air pollution episodes, improvement of public transportation, among others. Recent researches (MILAGRO 2006 campaign) found that currently it is necessary to implement emissions reduction actions for Volatile Organic Compounds, particulate matter with a diameter of less than 2.5 micrometers PM2.5 and Nitrogen Oxides, in order to reduce concentrations of ozone and fine particulate matter. Among the new measures to be implemented are: regulations for VOCs emissions in the industry and commercial sectors; regulation of the diesel fleet that includes fleets renewal, filters and particulate traps for in use vehicles and regulation of the cargo fleet; new schemes for reducing the number of vehicles circulating in the city; implementation of non-motorized mobility programs; among others.

  14. Focus on Energy: A School Transportation Handbook. Proceedings of the Midwest School Transportation Fleet Management Seminar (Lansing, Michigan, November 28-29, 1979).

    ERIC Educational Resources Information Center

    Michigan State Dept. of Commerce, Lansing.

    Presented are proceedings and supplementary reports of the Midwest School Transportation Fleet Management Seminar, which was held in Lansing, Michigan, November 28-29, 1979. Among the school bus energy management topics discussed are energy feasibility studies, the use of programmed information systems, energy conservation strategies, and…

  15. Tough budget year ahead, says NASA's Fisk

    NASA Astrophysics Data System (ADS)

    Cole, Stephen

    1992-02-01

    Lennard Fisk, head of NASA's space science and applications division, painted a bleak picture for space scientists on February 14 as the Bush administration's fiscal 1993 budget headed to Congress. Speaking at the annual meeting of the Space Science Working Group in Washington, D.C., Fisk said “It's going to take a miracle to get the $2,985 billion request” for space science in this year's NASA budget.Fisk held out no hope that programs already cut from the budget, such as the Comet Rendezvous/Asteroid Flyby mission, would be reinstated. The CRAF cancellation was “a $50 million issue in fiscal 1993,” said Fisk, “and it was $50 million that simply wasn't there.” His office “was under enormous pressure to take something off the plate,” he said.

  16. Mathematical optimization techniques for managing selective catalytic reduction for a fleet of coal-fired power plants

    NASA Astrophysics Data System (ADS)

    Alanis Pena, Antonio Alejandro

    Major commercial electricity generation is done by burning fossil fuels out of which coal-fired power plants produce a substantial quantity of electricity worldwide. The United States has large reserves of coal, and it is cheaply available, making it a good choice for the generation of electricity on a large scale. However, one major problem associated with using coal for combustion is that it produces a group of pollutants known as nitrogen oxides (NO x). NOx are strong oxidizers and contribute to ozone formation and respiratory illness. The Environmental Protection Agency (EPA) regulates the quantity of NOx emitted to the atmosphere in the United States. One technique coal-fired power plants use to reduce NOx emissions is Selective Catalytic Reduction (SCR). SCR uses layers of catalyst that need to be added or changed to maintain the required performance. Power plants do add or change catalyst layers during temporary shutdowns, but it is expensive. However, many companies do not have only one power plant, but instead they can have a fleet of coal-fired power plants. A fleet of power plants can use EPA cap and trade programs to have an outlet NOx emission below the allowances for the fleet. For that reason, the main aim of this research is to develop an SCR management mathematical optimization methods that, with a given set of scheduled outages for a fleet of power plants, minimizes the total cost of the entire fleet of power plants and also maintain outlet NO x below the desired target for the entire fleet. We use a multi commodity network flow problem (MCFP) that creates edges that represent all the SCR catalyst layers for each plant. This MCFP is relaxed because it does not consider average daily NOx constraint, and it is solved by a binary integer program. After that, we add the average daily NOx constraint to the model with a schedule elimination constraint (MCFPwSEC). The MCFPwSEC eliminates, one by one, the solutions that do not satisfy the average daily NOx constraint and the worst NH 3 slip until it finds the solution that satisfies that requirement. We introduce an algorithm called heuristic MCFPwSEC (HMCFPwSEC). When HMCFPwSEC algorithm starts, we calculate the cost of the edges estimating the average NH3 slip level, but after we have a schedule that satisfies the average daily NOx constraint and the worst NH3 slip, we update the cost of the edges with the average NH3 slip for this schedule. We repeat this process until we have the solution. Because HMCFPwSEC does not guarantee optimality, we compare its results with SGO, which is optimal, using computational experiments. The results between both models are very similar, the only important difference is the time to solve each model. Then, a fleet HMCFPwSEC (FHMCFPwSEC) uses HMCFPwSEC to create the SCR management plan for each plant of the fleet, with a discrete NOx emissions value for each plant. FHMCFPwSEC repeats this process with different discrete levels of NOx emissions, for each plant, in order to create a new problem with schedules with different cost and NO x emissions for each plant of the fleet. Finally, FHMCFPwSEC solves this new problem with a binary integer program, in order to satisfy a NO x emission value for the fleet that also minimizes the total cost for the fleet, and using each plant once. FHMCFPwSEC can work with single cut and also with multi-cut methods. Because FHMCFPwSEC does not guarantee optimality, we compare its results with fleet SGO (FSGO) using computational experiments. The results between both models are very similar, the only important difference is the time to solve each model. In the experiments, FHMCFPwSEC multi-cut targeting new layer always uses less time than FSGO.

  17. 46 CFR 131.420 - Manning and supervision.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Manning and supervision. 131.420 Section 131.420 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS OPERATIONS Sufficiency and Supervision of Crew of Survival Craft § 131.420 Manning and supervision. (a) There must be enough trained persons aboard each survival craf...

  18. Spacecraft on-board propulsion

    NASA Technical Reports Server (NTRS)

    Byers, D.

    1991-01-01

    The topics presented are covered in viewgraph form and include the following: (1) planetary dual mode; and (2) space station H/O and H2O/gas resistojet. The major benefits identified by users are: (1) 280 kG payload for MMII CRAF class mission; and (2) eliminate orbiter/year and N2H4 COF.

  19. Alternative Fuels Data Center: Propane Rolls on as Reliable Fleet Fuel

    Science.gov Websites

    AddThis.com... March 6, 2015 Propane Rolls on as Reliable Fleet Fuel " If we can save the district money alternative fuels program for our buses as a way to save money and clean up the air and environment for our can save the district money and prevent pollution for our kids' sake in the process, I don't see a

  20. The hepatitis B virus large surface protein (LHBs) is a transcriptional activator.

    PubMed

    Hildt, E; Saher, G; Bruss, V; Hofschneider, P H

    1996-11-01

    It has been shown that a C-terminally truncated form of the middle-sized hepatitis B virus (HBV) surface protein (MHBst) functions as a transcriptional activator. This function is dependent on the cytosolic orientation of the N-terminal PreS2 domain of MHBst, but in the case of wild-type MHBs, the PreS2 domain is contranslationally translocated into the ER lumen. Recent reports demonstrated that the PreS2 domain of the large HBV surface protein (LHBs) initially remains on the cytosolic side of the ER membrane after translation. Therefore, the question arose as to whether the LHBs protein exhibits the same transcriptional activator function as MHBst. We show that LHBs, like MHBst, is indeed able to activate a variety of promoter elements. There is evidence for a PKC-dependent activation of AP-1 and NF-kappa B by LHBs. Downstream of the PKC the functionality of c-Raf-1 kinase is a prerequisite for LHBs-dependent activation of AP-1 and NF-kappa B since inhibition of c-Raf-1 kinase abolishes LHBs-dependent transcriptional activation of AP-1 and NF-kappa B.

  1. 7 CFR 2903.2 - Purpose of the program.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., DEPARTMENT OF AGRICULTURE BIODIESEL FUEL EDUCATION PROGRAM General Information § 2903.2 Purpose of the program. The Biodiesel Fuel Education Program seeks to familiarize public and private vehicle fleet operators, other interested entities, and the public, with the benefits of biodiesel, a relatively new fuel...

  2. 7 CFR 2903.2 - Purpose of the program.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., DEPARTMENT OF AGRICULTURE BIODIESEL FUEL EDUCATION PROGRAM General Information § 2903.2 Purpose of the program. The Biodiesel Fuel Education Program seeks to familiarize public and private vehicle fleet operators, other interested entities, and the public, with the benefits of biodiesel, a relatively new fuel...

  3. 7 CFR 2903.2 - Purpose of the program.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., DEPARTMENT OF AGRICULTURE BIODIESEL FUEL EDUCATION PROGRAM General Information § 2903.2 Purpose of the program. The Biodiesel Fuel Education Program seeks to familiarize public and private vehicle fleet operators, other interested entities, and the public, with the benefits of biodiesel, a relatively new fuel...

  4. 7 CFR 2903.2 - Purpose of the program.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., DEPARTMENT OF AGRICULTURE BIODIESEL FUEL EDUCATION PROGRAM General Information § 2903.2 Purpose of the program. The Biodiesel Fuel Education Program seeks to familiarize public and private vehicle fleet operators, other interested entities, and the public, with the benefits of biodiesel, a relatively new fuel...

  5. 7 CFR 2903.2 - Purpose of the program.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., DEPARTMENT OF AGRICULTURE BIODIESEL FUEL EDUCATION PROGRAM General Information § 2903.2 Purpose of the program. The Biodiesel Fuel Education Program seeks to familiarize public and private vehicle fleet operators, other interested entities, and the public, with the benefits of biodiesel, a relatively new fuel...

  6. Inhibition of Chronic Pancreatitis and Murine Pancreatic Intraepithelial Neoplasia by a Dual Inhibitor of c-RAF and Soluble Epoxide Hydrolase in LSL-KrasG12D/Pdx-1-Cre Mice

    PubMed Central

    LIAO, JIE; HWANG, SUNG HEE; LI, HAONAN; LIU, JUN-YAN; HAMMOCK, BRUCE D.; YANG, GUANG-YU

    2016-01-01

    Mutation of Kirsten rat sarcoma viral oncogene homolog (KRAS) and chronic pancreatitis are the most common pathogenic events involved in human pancreatic carcinogenesis. In the process of long-standing chronic inflammation, aberrant metabolites of arachidonic acid play a crucial role in promoting carcinogenesis, in which the soluble epoxide hydrolase (sEH), as a pro-inflammatory enzyme, generally inactivates anti-inflammatory epoxyeicosatrienoic acids (EETs). Herein, we determined the effect of our newly-synthesized novel compound trans-4-{4-[3-(4-chloro-3-trifluoromethyl-phenyl)-ureido]-cyclohexyloxy}-pyridine-2-carboxylic acid methylamide (t-CUPM), a dual inhibitor of sEH and RAF1 proto-oncogene serine/threonine kinase (c-RAF), on inhibiting the development of pancreatitis and pancreatic intraepithelial neoplasia (mPanIN) in LSL-KrasG12D/Pdx1-Cre mice. The results showed that t-CUPM significantly reduced the severity of chronic pancreatitis, as measured by the extent of acini loss, inflammatory cell infiltration and stromal fibrosis. The progression of low-grade mPanIN I to high-grade mPanIN II/III was significantly suppressed. Inhibition of mutant Kras-transmitted phosphorylation of mitogen-activated protein kinase’s kinase/extracellular signal-regulated kinases was demonstrated in pancreatic tissues by western blots. Quantitative real-time polymerase chain reaction analysis revealed that t-CUPM treatment significantly reduced the levels of inflammatory cytokines including tumor necrosis facor-α, monocyte chemoattractant protein-1, as well as vascular adhesion molecule-1, and the levels of Sonic hedgehog and Gli transcription factor (Hedgehog pathway). Analysis of the eicosanoid profile revealed a significant increase of the EETs/dihydroxyeicosatrienoic acids ratio, which further confirmed sEH inhibition by t-CUPM. These results indicate that simultaneous inhibition of sEH and c-RAF by t-CUPM is important in preventing chronic pancreatitis and carcinogenesis. PMID:26722025

  7. Automotive fuel economy program

    DOT National Transportation Integrated Search

    2002-09-01

    The Automotive Fuel Economy Program Annual Update summarizes the fuel economy performance of the vehicle fleet and the activities of the National Highway Traffic Safety Administration (NHTSA) during 2001. Included in this report is a section summariz...

  8. Automotive fuel economy program

    DOT National Transportation Integrated Search

    2003-09-01

    The Automotive Fuel Economy Program Annual Update summarizes the fuel economy performance of the vehicle fleet and the activities of the National Highway Traffic Safety Administration (NHTSA) during 2002. Included in this report is a section summariz...

  9. Automotive fuel economy program

    DOT National Transportation Integrated Search

    2005-01-01

    The Automotive Fuel Economy Program Annual Update summarizes the fuel economy performance of the vehicle fleet during 2004, and the activities of the National Highway Traffic Safety Administration (NHTSA) to date, including a section summarizing curr...

  10. 76 FR 32359 - Privacy Act of 1974; System of Records

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-06

    ... Readiness (FFR) Internship Program (March 10, 2008, 73 FR 12713). Reason: Commander, Navy Installations...) employees at an installation level. N12308- 1, The Navy Fleet and Family Readiness (FFR) Internship Program...

  11. An assessment of the benefits of the use of NASA developed fuel conservative technology in the US commercial aircraft fleet

    NASA Technical Reports Server (NTRS)

    1975-01-01

    Cost and benefits of a fuel conservative aircraft technology program proposed by NASA are estimated. NASA defined six separate technology elements for the proposed program: (a) engine component improvement (b) composite structures (c) turboprops (d) laminar flow control (e) fuel conservative engine and (f) fuel conservative transport. There were two levels postulated: The baseline program was estimated to cost $490 million over 10 years with peak funding in 1980. The level two program was estimated to cost an additional $180 million also over 10 years. Discussions with NASA and with representatives of the major commercial airframe manufacturers were held to estimate the combinations of the technology elements most likely to be implemented, the potential fuel savings from each combination, and reasonable dates for incorporation of these new aircraft into the fleet.

  12. Examination of the costs, benefits and enery conservation aspects of the NASA aircraft fuel conservation technology program

    NASA Technical Reports Server (NTRS)

    1975-01-01

    The costs and benefits of the NASA Aircraft Fuel Conservation Technology Program are discussed. Consideration is given to a present worth analysis of the planned program expenditures, an examination of the fuel savings to be obtained by the year 2005 and the worth of this fuel savings relative to the investment required, a comparison of the program funding with that planned by other Federal agencies for energy conservation, an examination of the private industry aeronautical research and technology financial posture for the period FY 76 - FY 85, and an assessment of the potential impacts on air and noise pollution. To aid in this analysis, a computerized fleet mix forecasting model was developed. This model enables the estimation of fuel consumption and present worth of fuel expenditures for selected commerical aircraft fleet mix scenarios.

  13. Freight Wing Trailer Aerodynamics Final Technical Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sean Graham

    2007-10-31

    Freight Wing Incorporated utilized the opportunity presented by a DOE category two Inventions and Innovations grant to commercialize and improve upon aerodynamic technology for semi-tuck trailers, capable of decreasing heavy vehicle fuel consumption, related environmental damage, and U.S. consumption of foreign oil. Major project goals included the demonstration of aerodynamic trailer technology in trucking fleet operations, and the development and testing of second generation products. A great deal of past scientific research has demonstrated that streamlining box shaped semi-trailers can significantly reduce a truck’s fuel consumption. However, significant design challenges have prevented past concepts from meeting industry needs. Freight Wingmore » utilized a 2003 category one Inventions and Innovations grant to develop practical solutions to trailer aerodynamics. Fairings developed for the front, rear, and bottom of standard semi-trailers together demonstrated a 7% improvement to fuel economy in scientific tests conducted by the Transportation Research Center (TRC). Operational tests with major trucking fleets proved the functionality of the products, which were subsequently brought to market. This category two grant enabled Freight Wing to further develop, test and commercialize its products, resulting in greatly increased understanding and acceptance of aerodynamic trailer technology. Commercialization was stimulated by offering trucking fleets 50% cost sharing on trial implementations of Freight Wing products for testing and evaluation purposes. Over 230 fairings were implemented through the program with 35 trucking fleets including industry leaders such as Wal-Mart, Frito Lay and Whole Foods. The feedback from these testing partnerships was quite positive with product performance exceeding fleet expectations in many cases. Fleet feedback also was also valuable from a product development standpoint and assisted the design of several second generation products intended to further improve efficiency, lower costs, and enhance durability. Resulting products demonstrated a 30% efficiency improvement in full scale wind tunnel tests. The fuel savings of our most promising product, the “Belly Fairing” increased from 4% to 6% in scientific track and operational tests. The project successfully demonstrated the economic feasibility of trailer aerodynamics and positioned the technology to realize significant public benefits. Scientific testing conducted with partners such as the EPA Smartway program and Transport Canada clearly validated the fuel and emission saving potential of the technology. The Smartway program now recommends trailer aerodynamics as a certified fuel saving technology and is offering incentives such as low interest loans. Trailer aerodynamics can save average trucks over 1,100 gallons of fuel an 13 tons of emissions every 100,000 miles, a distance many trucks travel annually. These fuel savings produce a product return on investment period of one to two years in average fleet operations. The economic feasibility of the products was validated by participating fleets, several of which have since completed large implementations or demonstrated an interest in volume orders. The commercialization potential of the technology was also demonstrated, resulting in a national distribution and manufacturing partnership with a major industry supplier, Carrier Transicold. Consequently, Freight Wing is well positioned to continue marketing trailer aerodynamics to the trucking industry. The participation of leading fleets in this project served to break down the market skepticism that represents a primary barrier to widespread industry utilization. The benefits of widespread utilization of the technology could be quite significant for both the transportation industry and the public. Trailer aerodynamics could potentially save the U.S. trucking fleet over a billion gallons of fuel and 20 million tons of emissions annually.« less

  14. Micro-Controllable, Multi-Functional Interface Module for Digital MP: A Wearable Computer Security Application

    DTIC Science & Technology

    2004-05-01

    Army Soldier System Command: http://www.natick.armv.mil Role Name Facial Recognition Program Manager, Army Technical Lead Mark Chandler...security force with a facial recognition system. Mike Holloran, technology officer with the 6 Fleet, directed LCDR Hoa Ho and CAPT(s) Todd Morgan to...USN 6th Fleet was accomplished with the admiral expressing his support for continuing the evaluation of the a facial recognition system. This went

  15. Automotive fuel economy program

    DOT National Transportation Integrated Search

    2004-11-01

    The Automotive Fuel Economy Program Annual Update summarizes the fuel economy performance of the vehicle fleet during 2003, and the activities of the National Highway Traffic Safety Administration (NHTSA) to date. Included in this report is a section...

  16. 40 CFR 52.1073 - Approval status.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... following exception: (i) Distributors and retailers of gasoline-ethanol blends as defined by 40 CFR 80.27(d... either the Federal clean fuel fleet program or an alternative substitute program by May 15, 1994. (e)-(g...

  17. 40 CFR 52.1073 - Approval status.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... following exception: (i) Distributors and retailers of gasoline-ethanol blends as defined by 40 CFR 80.27(d... either the Federal clean fuel fleet program or an alternative substitute program by May 15, 1994. (e)-(g...

  18. The AKT-mTOR signalling pathway in kidney cancer tissues

    NASA Astrophysics Data System (ADS)

    Spirina, L. V.; Usynin, Y. A.; Kondakova, I. V.; Yurmazov, Z. A.; Slonimskaya, E. M.; Kolegova, E. S.

    2015-11-01

    An increased expression of phospho-AKT, m-TOR, glycogen regulator GSK-3-beta and transcription inhibitor 4E-BP1 was observed in kidney cancer tissues. Tumor size growth was associated with a high level of c-Raf and low content of phospho-m-TOR. Cancer metastasis development led to a decreased PTEN and phospho-AKT expression.

  19. Integrated operations payloads/fleet analysis study extension report

    NASA Technical Reports Server (NTRS)

    1971-01-01

    An analysis of the factors affecting the cost effectiveness of space shuttle operations is presented. The subjects discussed are: (1)payload data bank, (2) program risk analysis, (3)navigation satellite program, and (4) reusable launch systems.

  20. The atmospheric effects of stratospheric aircraft: A topical review

    NASA Technical Reports Server (NTRS)

    Johnston, Harold S.; Prather, M. J.; Watson, R. T.

    1991-01-01

    In the late 1960s the aircraft industry became interested in developing a fleet of supersonic transports (SSTs). Between 1972 and 1975, the Climatic Impact Assessment Program (CIAP) studied the possible environmental impact of SSTs. For environmental and economic reasons, the fleet of SSTs was not developed. The Upper Atmosphere Research Program (UARP) has recently undertaken the responsibility of directing scientific research needed to assess the atmospheric impact of supersonic transports. The UARP and the High-Speed Research Program asked Harold Johnston to review the current understanding of aircraft emissions and their effect on the stratosphere. Johnston and his colleagues have recently re-examined the SST problem using current models for stratospheric ozone chemistry. A unique view is given here of the current scientific issues and the lessons learned since the beginning of CIAP, and it links the current research program with the assessment process that began two years ago.

  1. Site operator program final report for fiscal years 1992 through 1996

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Francfort, J.E.; Bassett, R.R.; Birasco, S.

    The Site Operator Program was an electric vehicle testing and evaluation program sponsored by US Department of Energy and managed at the Idaho National Engineering and Environmental Laboratory. The Program`s goals included the field evaluation of electric vehicles in real-world applications and environments; the support of electric vehicle technology advancement; the development of infrastructure elements necessary to support significant electric vehicle use; and increasing the awareness and acceptance of electric vehicles. This report covers Program activities from 1992 to 1996. The Site Operator Program ended in September 1996, when it was superseded by the Field Operations Program. Electric vehicle testingmore » included baseline performance testing, which was performed in conjunction with EV America. The baseline performance parameters included acceleration, braking, range, energy efficiency, and charging time. The Program collected fleet operations data on electric vehicles operated by the Program`s thirteen partners, comprising electric utilities, universities, and federal agencies. The Program`s partners had over 250 electric vehicles, from vehicle converters and original equipment manufacturers, in their operating fleets. Test results are available via the World Wide Web site at http://ev.inel.gov/sop.« less

  2. Integration of fuzzy analytic hierarchy process and probabilistic dynamic programming in formulating an optimal fleet management model

    NASA Astrophysics Data System (ADS)

    Teoh, Lay Eng; Khoo, Hooi Ling

    2013-09-01

    This study deals with two major aspects of airlines, i.e. supply and demand management. The aspect of supply focuses on the mathematical formulation of an optimal fleet management model to maximize operational profit of the airlines while the aspect of demand focuses on the incorporation of mode choice modeling as parts of the developed model. The proposed methodology is outlined in two-stage, i.e. Fuzzy Analytic Hierarchy Process is first adopted to capture mode choice modeling in order to quantify the probability of probable phenomena (for aircraft acquisition/leasing decision). Then, an optimization model is developed as a probabilistic dynamic programming model to determine the optimal number and types of aircraft to be acquired and/or leased in order to meet stochastic demand during the planning horizon. The findings of an illustrative case study show that the proposed methodology is viable. The results demonstrate that the incorporation of mode choice modeling could affect the operational profit and fleet management decision of the airlines at varying degrees.

  3. Broadband Outdoor Radiometer Calibration Process for the Atmospheric Radiation Measurement Program

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dooraghi, Michael

    2015-09-01

    The Atmospheric Radiation Measurement program (ARM) maintains a fleet of monitoring stations to aid in the improved scientific understanding of the basic physics related to radiative feedback processes in the atmosphere, particularly the interactions among clouds and aerosols. ARM obtains continuous measurements and conducts field campaigns to provide data products that aid in the improvement and further development of climate models. All of the measurement campaigns include a suite of solar measurements. The Solar Radiation Research Laboratory at the National Renewable Energy Laboratory supports ARM's full suite of stations in a number of ways, including troubleshooting issues that arise asmore » part of the data-quality reviews; managing engineering changes to the standard setup; and providing calibration services and assistance to the full fleet of solar-related instruments, including pyranometers, pyrgeometers, pyrheliometers, as well as the temperature/relative humidity probes, multimeters, and data acquisition systems that are used in the calibrations performed at the Southern Great Plains Radiometer Calibration Facility. This paper discusses all aspects related to the support provided to the calibration of the instruments in the solar monitoring fleet.« less

  4. Aviation Safety Modeling and Simulation (ASMM) Propulsion Fleet Modeling: A Tool for Semi-Automatic Construction of CORBA-based Applications from Legacy Fortran Programs

    NASA Technical Reports Server (NTRS)

    Sang, Janche

    2003-01-01

    Within NASA's Aviation Safety Program, NASA GRC participates in the Modeling and Simulation Project called ASMM. NASA GRC s focus is to characterize the propulsion systems performance from a fleet management and maintenance perspective by modeling and through simulation predict the characteristics of two classes of commercial engines (CFM56 and GE90). In prior years, the High Performance Computing and Communication (HPCC) program funded, NASA Glenn in developing a large scale, detailed simulations for the analysis and design of aircraft engines called the Numerical Propulsion System Simulation (NPSS). Three major aspects of this modeling included the integration of different engine components, coupling of multiple disciplines, and engine component zooming at appropriate level fidelity, require relatively tight coupling of different analysis codes. Most of these codes in aerodynamics and solid mechanics are written in Fortran. Refitting these legacy Fortran codes with distributed objects can increase these codes reusability. Aviation Safety s modeling and simulation use in characterizing fleet management has similar needs. The modeling and simulation of these propulsion systems use existing Fortran and C codes that are instrumental in determining the performance of the fleet. The research centers on building a CORBA-based development environment for programmers to easily wrap and couple legacy Fortran codes. This environment consists of a C++ wrapper library to hide the details of CORBA and an efficient remote variable scheme to facilitate data exchange between the client and the server model. Additionally, a Web Service model should also be constructed for evaluation of this technology s use over the next two- three years.

  5. Designing of a Fleet-Leader Program for Carbon Composite Overwrapped Pressure Vessels

    NASA Technical Reports Server (NTRS)

    Murthy, Pappu L.N.; Phoenix, S. Leigh

    2009-01-01

    Composite Overwrapped Pressure Vessels (COPVs) are often used for storing pressurant gases on board spacecraft when mass saving is a prime requirement. Substantial weight savings can be achieved compared to all metallic pressure vessels. For example, on the space shuttle, replacement of all metallic pressure vessels with Kevlar COPVs resulted in a weight savings of about 30 percent. Mass critical space applications such as the Ares and Orion vehicles are currently being planned to use as many COPVs as possible in place of all-metallic pressure vessels to minimize the overall mass of the vehicle. Due to the fact that overwraps are subjected to sustained loads during long periods of a mission, stress rupture failure is a major concern. It is, therefore, important to ascertain the reliability of these vessels by analysis, since it is practically impossible to show by experimental testing the reliability of flight quality vessels. Also, it is a common practice to set aside flight quality vessels as "fleet leaders" in a test program where these vessels are subjected to slightly accelerated operating conditions so that they lead the actual flight vessels both in time and load. The intention of fleet leaders is to provide advanced warning if there is a serious design flaw in the vessels so that a major disaster in the flight vessels can be averted with advance warning. On the other hand, the accelerating conditions must be not so severe as to be prone to false alarms. The primary focus of the present paper is to provide an analytical basis for designing a viable fleet leader program for carbon COPVs. The analysis is based on a stress rupture behavior model incorporating Weibull statistics and power-law sensitivity of life to fiber stress level.

  6. Sustainable Federal Fleets: Deploying Electric Vehicles and Electric Vehicle Supply Equipment

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    The U.S. Department of Energy (DOE) Federal Energy Management Program (FEMP) helps federal agencies reduce petroleum consumption and increase alternative fuel use through its resources for Sustainable Federal Fleets. To assist agencies with the transition to plug-in electric vehicles (PEVs), including battery electric vehicles (BEVs) and plug-in hybrid electric vehicles (PHEVs), FEMP offers technical guidance on electric vehicle supply equipment (EVSE) installations and site-specific planning through partnerships with the National Renewable Energy Laboratory's (NREL's) EVSE Tiger Teams.

  7. System of systems design: Evaluating aircraft in a fleet context using reliability and non-deterministic approaches

    NASA Astrophysics Data System (ADS)

    Frommer, Joshua B.

    This work develops and implements a solution framework that allows for an integrated solution to a resource allocation system-of-systems problem associated with designing vehicles for integration into an existing fleet to extend that fleet's capability while improving efficiency. Typically, aircraft design focuses on using a specific design mission while a fleet perspective would provide a broader capability. Aspects of design for both the vehicles and missions may be, for simplicity, deterministic in nature or, in a model that reflects actual conditions, uncertain. Toward this end, the set of tasks or goals for the to-be-planned system-of-systems will be modeled more accurately with non-deterministic values, and the designed platforms will be evaluated using reliability analysis. The reliability, defined as the probability of a platform or set of platforms to complete possible missions, will contribute to the fitness of the overall system. The framework includes building surrogate models for metrics such as capability and cost, and includes the ideas of reliability in the overall system-level design space. The concurrent design and allocation system-of-systems problem is a multi-objective mixed integer nonlinear programming (MINLP) problem. This study considered two system-of-systems problems that seek to simultaneously design new aircraft and allocate these aircraft into a fleet to provide a desired capability. The Coast Guard's Integrated Deepwater System program inspired the first problem, which consists of a suite of search-and-find missions for aircraft based on descriptions from the National Search and Rescue Manual. The second represents suppression of enemy air defense operations similar to those carried out by the U.S. Air Force, proposed as part of the Department of Defense Network Centric Warfare structure, and depicted in MILSTD-3013. The two problems seem similar, with long surveillance segments, but because of the complex nature of aircraft design, the analysis of the vehicle for high-speed attack combined with a long loiter period is considerably different from that for quick cruise to an area combined with a low speed search. However, the framework developed to solve this class of system-of-systems problem handles both scenarios and leads to a solution type for this kind of problem. On the vehicle-level of the problem, different technology can have an impact on the fleet-level. One such technology is Morphing, the ability to change shape, which is an ideal candidate technology for missions with dissimilar segments, such as the aforementioned two. A framework, using surrogate models based on optimally-sized aircraft, and using probabilistic parameters to define a concept of operations, is investigated; this has provided insight into the setup of the optimization problem, the use of the reliability metric, and the measurement of fleet level impacts of morphing aircraft. The research consisted of four phases. The two initial phases built and defined the framework to solve system-of-systems problem; these investigations used the search-and-find scenario as the example application. The first phase included the design of fixed-geometry and morphing aircraft for a range of missions and evaluated the aircraft capability using non-deterministic mission parameters. The second phase introduced the idea of multiple aircraft in a fleet, but only considered a fleet consisting of one aircraft type. The third phase incorporated the simultaneous design of a new vehicle and allocation into a fleet for the search-and-find scenario; in this phase, multiple types of aircraft are considered. The fourth phase repeated the simultaneous new aircraft design and fleet allocation for the SEAD scenario to show that the approach is not specific to the search-and-find scenario. The framework presented in this work appears to be a viable approach for concurrently designing and allocating constituents in a system, specifically aircraft in a fleet. The research also shows that new technology impact can be assessed at the fleet level using conceptual design principles.

  8. The challenge to NOx emission control for heavy-duty diesel vehicles in China

    NASA Astrophysics Data System (ADS)

    Wu, Y.; Zhang, S. J.; Li, M. L.; Ge, Y. S.; Shu, J. W.; Zhou, Y.; Xu, Y. Y.; Hu, J. N.; Liu, H.; Fu, L. X.; He, K. B.; Hao, J. M.

    2012-07-01

    China's new "Twelfth Five-Year Plan" set a target for total NOx emission reduction of 10% for the period of 2011-2015. Heavy-duty diesel vehicles (HDDVs) have been considered a major contributor to NOx emissions in China. Beijing initiated a comprehensive vehicle test program in 2008. This program included a sub-task for measuring on-road emission profiles of hundreds of HDDVs using portable emission measurement systems (PEMS). The major finding is that neither the on-road distance-specific (g km -1) nor brake-specific (g kW h-1) NOx emission factors for diesel buses and heavy-duty diesel trucks improved in most cases as emission standards became more stringent. For example, the average NOx emission factors for Euro II, Euro III and Euro IV buses are 11.3±3.3 g km-1, 12.5± 1.3 g km-1, and 11.8±2.0 g km-1, respectively. No statistically significant difference in NOx emission factors was observed between Euro II and III buses. Even for Euro IV buses equipped with SCR systems, the NOx emission factors are similar to Euro III buses. The data regarding real-time engine performance of Euro IV buses suggest the engine certification cycles did not reflect their real-world operating conditions. These new on-road test results indicate that previous estimates of total NOx emissions for HDDV fleet may be significantly underestimated. The new estimate in total NOx emissions for the Beijing HDDV fleet in 2009 is 37.0 Gg, an increase of 45% compared to the previous study. Further, we estimate that the total NOx emissions for the national HDDV fleet in 2009 are approximately 4.0 Tg, higher by 1.0 Tg (equivalent to 18% of total NOx emissions for vehicle fleet in 2009) than that estimated in the official report. This would also result in 4% increase in estimation of national anthropogenic NOx emissions. More effective control measures (such as promotion of CNG buses and a new in-use compliance testing program) are urged to secure the goal of total NOxmitigation for the HDDV fleet in the future.

  9. The challenge to NOx emission control for heavy-duty diesel vehicles in China

    NASA Astrophysics Data System (ADS)

    Wu, Y.; Zhang, S. J.; Li, M. L.; Ge, Y. S.; Shu, J. W.; Zhou, Y.; Xu, Y. Y.; Hu, J. N.; Liu, H.; Fu, L. X.; He, K. B.; Hao, J. M.

    2012-10-01

    China's new "Twelfth Five-Year Plan" set a target for total NOx emission reduction of 10% for the period of 2011-2015. Heavy-duty diesel vehicles (HDDVs) have been considered a major contributor to NOx emissions in China. Beijing initiated a comprehensive vehicle test program in 2008. This program included a sub-task for measuring on-road emission profiles of hundreds of HDDVs using portable emission measurement systems (PEMS). The major finding is that neither the on-road distance-specific (g km-1) nor brake-specific (g kWh-1) NOx emission factors for diesel buses and heavy-duty diesel trucks improved in most cases as emission standards became more stringent. For example, the average NOx emission factors for Euro II, Euro III and Euro IV buses are 11.3 ± 3.3 g km-1, 12.5 ± 1.3 g km-1, and 11.8 ± 2.0 g km-1, respectively. No statistically significant difference in NOx emission factors was observed between Euro II and III buses. Even for Euro IV buses equipped with SCR systems, the NOx emission factors are similar to Euro III buses. The data regarding real-time engine performance of Euro IV buses suggest the engine certification cycles did not reflect their real-world operating conditions. These new on-road test results indicate that previous estimates of total NOx emissions for HDDV fleet may be significantly underestimated. The new estimate in total NOx emissions for the Beijing HDDV fleet in 2009 is 37.0 Gg, an increase of 45% compared to the previous study. Further, we estimate that the total NOx emissions for the national HDDV fleet in 2009 are approximately 4.0 Tg, higher by 1.0 Tg (equivalent to 18% of total NOx emissions for vehicle fleet in 2009) than that estimated in the official report. This would also result in 4% increase in estimation of national anthropogenic NOx emissions. More effective control measures (such as promotion of CNG buses and a new in-use compliance testing program) are urged to secure the goal of total NOx mitigation for the HDDV fleet in the future.

  10. Robust Constrained Blackbox Optimization with Surrogates

    DTIC Science & Technology

    2015-05-21

    algorithms with OPAL . Mathematical Programming Computation, 6(3):233–254, 2014. 6. M.S. Ouali, H. Aoudjit, and C. Audet. Replacement scheduling of a fleet of...Orban. Optimization of Algorithms with OPAL . Mathematical Programming Computation, 6(3), 233-254, September 2014. DISTRIBUTION A: Distribution

  11. 10 CFR 490.206 - Violations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Violations. 490.206 Section 490.206 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State Fleet Program § 490.206 Violations. Violations of this subpart are subject to investigation and enforcement under subpart...

  12. 10 CFR 490.206 - Violations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Violations. 490.206 Section 490.206 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State Fleet Program § 490.206 Violations. Violations of this subpart are subject to investigation and enforcement under subpart...

  13. 10 CFR 490.206 - Violations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 3 2014-01-01 2014-01-01 false Violations. 490.206 Section 490.206 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State Fleet Program § 490.206 Violations. Violations of this subpart are subject to investigation and enforcement under subpart...

  14. 10 CFR 490.206 - Violations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 3 2012-01-01 2012-01-01 false Violations. 490.206 Section 490.206 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State Fleet Program § 490.206 Violations. Violations of this subpart are subject to investigation and enforcement under subpart...

  15. 10 CFR 490.206 - Violations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false Violations. 490.206 Section 490.206 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State Fleet Program § 490.206 Violations. Violations of this subpart are subject to investigation and enforcement under subpart...

  16. 78 FR 68764 - Fisheries Off West Coast States; Pacific Coast Groundfish Fishery Management Plan; Commercial...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-15

    ... (coop) programs for the at-sea mothership and catcher/processor trawl fleets (whiting only). Since that... permit holder (vessel owner) to change their vessel ownership, 9. Clarify that the processor obligation..., Mothership Coop (MS) Program--Whiting At-sea Trawl Fishery, and Catcher-Processor (C/P) Coop Program--Whiting...

  17. The Role of Dimerization in Raf Signaling | Center for Cancer Research

    Cancer.gov

    One frequently mutated pathway in a variety of cancers and developmental disorders is the Ras-Raf-MEK-ERK cascade. Normally, binding of a growth factor to its receptor switches on Ras, which, in turn, activates one or more of the Raf kinase family members, A-Raf, B-Raf, and C-Raf. Rafs perpetuate the signal by phosphorylating and activating MEK, another kinase that

  18. 78 FR 75268 - Fisheries Off West Coast States; Pacific Coast Groundfish Fishery; Trawl Rationalization Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-11

    ... toward environmental conservation and economic sustainability before cost recovery. NMFS should... fleet's flexibility and economic efficiency will enhance the trawl rationalization program's durability... before economic benefits have been adequately realized and while fishermen are struggling to pay...

  19. 10 CFR 490.502 - Creditable actions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 3 2012-01-01 2012-01-01 false Creditable actions. 490.502 Section 490.502 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Fueled Vehicle Credit Program § 490.502 Creditable actions. A fleet or covered person becomes entitled to alternative...

  20. 10 CFR 490.201 - Alternative fueled vehicle acquisition mandate schedule.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 3 2012-01-01 2012-01-01 false Alternative fueled vehicle acquisition mandate schedule. 490.201 Section 490.201 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State Fleet Program § 490.201 Alternative fueled vehicle acquisition mandate...

  1. 10 CFR 490.201 - Alternative fueled vehicle acquisition mandate schedule.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Alternative fueled vehicle acquisition mandate schedule. 490.201 Section 490.201 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State Fleet Program § 490.201 Alternative fueled vehicle acquisition mandate...

  2. 10 CFR 490.502 - Creditable actions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Creditable actions. 490.502 Section 490.502 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Fueled Vehicle Credit Program § 490.502 Creditable actions. A fleet or covered person becomes entitled to alternative...

  3. 10 CFR 490.201 - Alternative fueled vehicle acquisition mandate schedule.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Alternative fueled vehicle acquisition mandate schedule. 490.201 Section 490.201 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State Fleet Program § 490.201 Alternative fueled vehicle acquisition mandate...

  4. 10 CFR 490.502 - Creditable actions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 3 2014-01-01 2014-01-01 false Creditable actions. 490.502 Section 490.502 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Fueled Vehicle Credit Program § 490.502 Creditable actions. A fleet or covered person becomes entitled to alternative...

  5. 10 CFR 490.201 - Alternative fueled vehicle acquisition mandate schedule.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false Alternative fueled vehicle acquisition mandate schedule. 490.201 Section 490.201 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State Fleet Program § 490.201 Alternative fueled vehicle acquisition mandate...

  6. 10 CFR 490.201 - Alternative fueled vehicle acquisition mandate schedule.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 3 2014-01-01 2014-01-01 false Alternative fueled vehicle acquisition mandate schedule. 490.201 Section 490.201 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State Fleet Program § 490.201 Alternative fueled vehicle acquisition mandate...

  7. 10 CFR 490.502 - Creditable actions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false Creditable actions. 490.502 Section 490.502 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Fueled Vehicle Credit Program § 490.502 Creditable actions. A fleet or covered person becomes entitled to alternative...

  8. Magnetic-based NDE of prestressed and post-tensioned concrete members : the MFL system : tech brief.

    DOT National Transportation Integrated Search

    1997-02-01

    This report assesses the effectiveness of vehicle retirement programs in reducing emissions from the motor vehicle fleets, as well as examining the effect of a program's timing on the magnitude of these reductions. First, the eastern Massachusetts no...

  9. Design, development and evaluation of driver wellness programs. Technical memorandum 3 : pilot test results and marketing plan

    DOT National Transportation Integrated Search

    1999-10-31

    In May, 1997, the National Private Truck Councils (NPTC) Private Fleet Management Institute (PFMI) began a research program in cooperation with Sue Roberts Health Concepts, Inc., ATA Foundation, Inc., and the Federal Motor Carrier Safety Administr...

  10. 10 CFR 490.502 - Creditable actions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Creditable actions. 490.502 Section 490.502 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Fueled Vehicle Credit Program § 490.502 Creditable actions. A fleet or covered person becomes entitled to alternative...

  11. The United States Naval Nuclear Propulsion Program - Over 151 Million Miles Safely Steamed on Nuclear Power

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None, None

    NNSA’s third mission pillar is supporting the U.S. Navy’s ability to protect and defend American interests across the globe. The Naval Reactors Program remains at the forefront of technological developments in naval nuclear propulsion and ensures a commanding edge in warfighting capabilities by advancing new technologies and improvements in naval reactor performance and reliability. In 2015, the Naval Nuclear Propulsion Program pioneered advances in nuclear reactor and warship design – such as increasing reactor lifetimes, improving submarine operational effectiveness, and reducing propulsion plant crewing. The Naval Reactors Program continued its record of operational excellence by providing the technical expertise requiredmore » to resolve emergent issues in the Nation’s nuclear-powered fleet, enabling the Fleet to safely steam more than two million miles. Naval Reactors safely maintains, operates, and oversees the reactors on the Navy’s 82 nuclear-powered warships, constituting more than 45 percent of the Navy’s major combatants.« less

  12. Air Vehicle Integration and Technology Research (AVIATR). Task Order 0003: Condition-Based Maintenance Plus Structural Integrity (CBM+SI) Demonstration (September 2011 to March 2012)

    DTIC Science & Technology

    2012-03-01

    the potential maintenance plans are compared via the TPMs , which are related to the cost of ownership of the fleet and to aircraft availability. 7...due to maintenance of the wing system is reported because this measure has a straightforward interpretation. This TPM is referred to as Fleet DT...3.2.2. Maintenance Parameters The F-15 Program has indicated that, in practice , maintenance actions are generally performed on multiples of 200 FH. For

  13. Improving aircraft energy efficiency

    NASA Technical Reports Server (NTRS)

    Povinelli, F. P.; Klineberg, J. M.; Kramer, J. J.

    1976-01-01

    Investigations conducted by a NASA task force concerning the development of aeronautical fuel-conservation technology are considered. The task force estimated the fuel savings potential, prospects for implementation in the civil air-transport fleet, and the impact of the technology on air-transport fuel use. Propulsion advances are related to existing engines in the fleet, to new production of current engine types, and to new engine designs. Studies aimed at the evolutionary improvement of aerodynamic design and a laminar flow control program are discussed and possibilities concerning the use of composite structural materials are examined.

  14. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Compliance rates for covered state government and alternative fuel provider fleets under the Alternative Fuel Transportation Program (pursuant to the Energy Policy Act or EPAct) are reported for MY 2013/FY 2014 in this publication.

  15. Delivering Savings with Open Architecture and Product Lines

    DTIC Science & Technology

    2011-04-30

    p.m. Chair: Christopher Deegan , Executive Director, Program Executive Office for Integrated Warfare Systems Delivering Savings with Open...Architectures Walt Scacchi and Thomas Alspaugh, Institute for Software Research Christopher Deegan —Executive Director, Program Executive Officer...Integrated Warfare Systems (PEO IWS). Mr. Deegan directs the development, acquisition, and fleet support of 150 combat weapon system programs managed by 350

  16. 78 FR 54242 - 36(b)(1) Arms Sales Notification

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-03

    ... elements of logistical and program support. The estimated cost is $1.2 billion. This proposed sale will... support services, and other related elements of logistical and program support. (iv) Military Department... logistical support to sustain the combat and operational readiness of its existing aircraft fleet. The...

  17. 10 CFR 490.506 - Alternative fueled vehicle credit transfers.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Alternative fueled vehicle credit transfers. 490.506 Section 490.506 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Fueled Vehicle Credit Program § 490.506 Alternative fueled vehicle credit transfers. (a) Any fleet...

  18. 10 CFR 490.506 - Alternative fueled vehicle credit transfers.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false Alternative fueled vehicle credit transfers. 490.506 Section 490.506 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Fueled Vehicle Credit Program § 490.506 Alternative fueled vehicle credit transfers. (a) Any fleet...

  19. 10 CFR 490.506 - Alternative fueled vehicle credit transfers.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Alternative fueled vehicle credit transfers. 490.506 Section 490.506 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Fueled Vehicle Credit Program § 490.506 Alternative fueled vehicle credit transfers. (a) Any fleet...

  20. 10 CFR 490.506 - Alternative fueled vehicle credit transfers.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 3 2012-01-01 2012-01-01 false Alternative fueled vehicle credit transfers. 490.506 Section 490.506 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Fueled Vehicle Credit Program § 490.506 Alternative fueled vehicle credit transfers. (a) Any fleet...

  1. 10 CFR 490.506 - Alternative fueled vehicle credit transfers.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 3 2014-01-01 2014-01-01 false Alternative fueled vehicle credit transfers. 490.506 Section 490.506 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Fueled Vehicle Credit Program § 490.506 Alternative fueled vehicle credit transfers. (a) Any fleet...

  2. Integrated operations/payloads/fleet analysis. Volume 2: Payloads

    NASA Technical Reports Server (NTRS)

    1971-01-01

    The payloads for NASA and non-NASA missions of the integrated fleet are analyzed to generate payload data for the capture and cost analyses for the period 1979 to 1990. Most of the effort is on earth satellites, probes, and planetary missions because of the space shuttle's ability to retrieve payloads for repair, overhaul, and maintenance. Four types of payloads are considered: current expendable payload; current reusable payload; low cost expendable payload, (satellite to be used with expendable launch vehicles); and low cost reusable payload (satellite to be used with the space shuttle/space tug system). Payload weight analysis, structural sizing analysis, and the influence of mean mission duration on program cost are also discussed. The payload data were computerized, and printouts of the data for payloads for each program or mission are included.

  3. An Integer Programming Model For Solving Heterogeneous Vehicle Routing Problem With Hard Time Window considering Service Choice

    NASA Astrophysics Data System (ADS)

    Susilawati, Enny; Mawengkang, Herman; Efendi, Syahril

    2018-01-01

    Generally a Vehicle Routing Problem with time windows (VRPTW) can be defined as a problem to determine the optimal set of routes used by a fleet of vehicles to serve a given set of customers with service time restrictions; the objective is to minimize the total travel cost (related to the travel times or distances) and operational cost (related to the number of vehicles used). In this paper we address a variant of the VRPTW in which the fleet of vehicle is heterogenic due to the different size of demand from customers. The problem, called Heterogeneous VRP (HVRP) also includes service levels. We use integer programming model to describe the problem. A feasible neighbourhood approach is proposed to solve the model.

  4. Shaping Air Mobility Forces for Future Relevance

    DTIC Science & Technology

    2017-01-01

    Published by Air University Press in January 2017 Disclaimer Opinions, conclusions, and recommendations expressed or implied within are solely those of the...other decision makers. Each paper can also be a valuable tool for defining further research. These studies are available elec- tronically or in...CRAF, 415 of which were large and mostly wide-body aircraft suited to international operations.3 The military compo- nents of the NAMS are twofold and

  5. CoMA: A high resolution Time-Of-Flight Secondary Ion Mass Spectrometer (TOF-SIMS) for in situ analysis of cometary matter

    NASA Technical Reports Server (NTRS)

    Zscheeg, Harry; Kissel, J.; Natour, G.

    1992-01-01

    A lot of clues concerning the origin of the solar system can be found by sending an exploring spacecraft to a rendezvous with a comet. The space experiment CoMA, which will measure the elemental, isotopic, and molecular composition of cometary dust grains is described. It will be flown on NASA's Comet Rendezvous Asteroid Flyby (CRAF) mission.

  6. Spacecraft telecommunications system mass estimates

    NASA Technical Reports Server (NTRS)

    Yuen, J. H.; Sakamoto, L. L.

    1988-01-01

    Mass is the most important limiting parameter for present-day planetary spacecraft design, In fact, the entire design can be characterized by mass. The more efficient the design of the spacecraft, the less mass will be required. The communications system is an essential and integral part of planetary spacecraft. A study is presented of the mass attributable to the communications system for spacecraft designs used in recent missions in an attempt to help guide future design considerations and research and development efforts. The basic approach is to examine the spacecraft by subsystem and allocate a portion of each subsystem to telecommunications. Conceptually, this is to divide the spacecraft into two parts, telecommunications and nontelecommunications. In this way, it is clear what the mass attributable to the communications system is. The percentage of mass is calculated using the actual masses of the spacecraft parts, except in the case of CRAF. In that case, estimated masses are used since the spacecraft was not yet built. The results show that the portion of the spacecraft attributable to telecommunications is substantial. The mass fraction for Voyager, Galileo, and CRAF (Mariner Mark 2) is 34, 19, and 18 percent, respectively. The large reduction of telecommunications mass from Voyager to Galileo is mainly due to the use of a deployable antenna instead of the solid antenna on Voyager.

  7. Design and Discovery of N -(2-Methyl-5'-morpholino-6'-((tetrahydro-2 H -pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nishiguchi, Gisele A.; Rico, Alice; Tanner, Huw

    RAS oncogenes have been implicated in >30% of human cancers, all representing high unmet medical need. The exquisite dependency on CRAF kinase in KRAS mutant tumors has been established in genetically engineered mouse models and human tumor cells. To date, many small molecule approaches are under investigation to target CRAF, yet kinase-selective and cellular potent inhibitors remain challenging to identify. Herein, we describe 14 (RAF709) [Aversa, Biaryl amide compounds as kinase inhibitors and their preparation. WO 2014151616, 2014], a selective B/C RAF inhibitor, which was developed through a hypothesis-driven approach focusing on drug-like properties. A key challenge encountered in themore » medicinal chemistry campaign was maintaining a balance between good solubility and potent cellular activity (suppression of pMEK and proliferation) in KRAS mutant tumor cell lines. We investigated the small molecule crystal structure of lead molecule 7 and hypothesized that disruption of the crystal packing would improve solubility, which led to a change from N-methylpyridone to a tetrahydropyranyl oxy-pyridine derivative. 14 proved to be soluble, kinase selective, and efficacious in a KRAS mutant xenograft model.« less

  8. 49 CFR 396.19 - Inspector qualifications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... mechanic or inspector in a motor carrier or intermodal equipment maintenance program; (C) Experience as a mechanic or inspector in commercial motor vehicle maintenance at a commercial garage, fleet leasing company...

  9. 49 CFR 396.19 - Inspector qualifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... mechanic or inspector in a motor carrier or intermodal equipment maintenance program; (C) Experience as a mechanic or inspector in commercial motor vehicle maintenance at a commercial garage, fleet leasing company...

  10. 49 CFR 396.19 - Inspector qualifications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... mechanic or inspector in a motor carrier or intermodal equipment maintenance program; (C) Experience as a mechanic or inspector in commercial motor vehicle maintenance at a commercial garage, fleet leasing company...

  11. 49 CFR 396.19 - Inspector qualifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... mechanic or inspector in a motor carrier or intermodal equipment maintenance program; (C) Experience as a mechanic or inspector in commercial motor vehicle maintenance at a commercial garage, fleet leasing company...

  12. 49 CFR 396.19 - Inspector qualifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... mechanic or inspector in a motor carrier or intermodal equipment maintenance program; (C) Experience as a mechanic or inspector in commercial motor vehicle maintenance at a commercial garage, fleet leasing company...

  13. Alternative Fuels Data Center

    Science.gov Websites

    of the following measures: Payment of incentives to customers that install EVSE; Time-of-use rates customers; and Technical assistance programs for government fleets and private organizations. Utilities may

  14. Major Impact of Fleet Renewal Over Airports Located in the Most Important Region of Brazil

    NASA Technical Reports Server (NTRS)

    Maters, Rafael Waltz; deRoodeTorres, Roberta; Santo, Respicio A. Espirito, Jr.

    2003-01-01

    The present article discusses and analyses the major impacts of the Brazilian carriers fleet renewal regarding Brazilian airport infrastructure in the most important region of the country, the Southeast (SE). A brief historical overview of the country's airline fleet will be presented, demonstrating the need for its renewal (m fact, Brazilian carriers started a major fleet renewal program m the last five years), while analyzing the periods in which a new breed of aircraft was put into service by the major carriers operating in the SE region. The trend of operating the classic regional jets plus the forthcoming entry into service of the "large regional jets" (LRJ, 70-115 seaters) in several point-to-point routes are presented along with the country's carriers" reality of operating these former aircraft in several high-capacity and medium-range routes. The article will focus on the ability of four of the major Southeast's airports to cope with the fleet modernization, mainly due to the fact that the region studied is the most socioeconomic developed, by far, with the largest demand for air transportation, thus making the impacts much more perceptible for the communities and the airport management involved. With the emergence of these impacts, several new projects and investments are being discussed and pushed forward, despite budgetary constrains being a reality in almost every Brazilian city, even in the SE region. In view of this, the paper presents how the general planning could be carried out in order to adapt the airports' infrastructures in function of the proposed (and in some cases, necessary) fleet renewal. Ultimately, we will present the present picture and two future scenarios m order to determine the level of service in the existent passenger terminal facilities in the wake of the possible operation of several new aircraft. Keywords: Airline fleet planning, Airport planning, Regional development, Regional Jets.

  15. Discrete Optimization Model for Vehicle Routing Problem with Scheduling Side Cosntraints

    NASA Astrophysics Data System (ADS)

    Juliandri, Dedy; Mawengkang, Herman; Bu'ulolo, F.

    2018-01-01

    Vehicle Routing Problem (VRP) is an important element of many logistic systems which involve routing and scheduling of vehicles from a depot to a set of customers node. This is a hard combinatorial optimization problem with the objective to find an optimal set of routes used by a fleet of vehicles to serve the demands a set of customers It is required that these vehicles return to the depot after serving customers’ demand. The problem incorporates time windows, fleet and driver scheduling, pick-up and delivery in the planning horizon. The goal is to determine the scheduling of fleet and driver and routing policies of the vehicles. The objective is to minimize the overall costs of all routes over the planning horizon. We model the problem as a linear mixed integer program. We develop a combination of heuristics and exact method for solving the model.

  16. 10 CFR 490.203 - Light Duty Alternative Fueled Vehicle Plan.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false Light Duty Alternative Fueled Vehicle Plan. 490.203 Section 490.203 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State Fleet Program § 490.203 Light Duty Alternative Fueled Vehicle Plan. (a) General Provisions...

  17. 10 CFR 490.203 - Light Duty Alternative Fueled Vehicle Plan.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Light Duty Alternative Fueled Vehicle Plan. 490.203 Section 490.203 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State Fleet Program § 490.203 Light Duty Alternative Fueled Vehicle Plan. (a) General Provisions...

  18. 10 CFR 490.203 - Light Duty Alternative Fueled Vehicle Plan.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 3 2014-01-01 2014-01-01 false Light Duty Alternative Fueled Vehicle Plan. 490.203 Section 490.203 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State Fleet Program § 490.203 Light Duty Alternative Fueled Vehicle Plan. (a) General Provisions...

  19. 10 CFR 490.203 - Light Duty Alternative Fueled Vehicle Plan.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 3 2012-01-01 2012-01-01 false Light Duty Alternative Fueled Vehicle Plan. 490.203 Section 490.203 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State Fleet Program § 490.203 Light Duty Alternative Fueled Vehicle Plan. (a) General Provisions...

  20. 10 CFR 490.203 - Light Duty Alternative Fueled Vehicle Plan.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Light Duty Alternative Fueled Vehicle Plan. 490.203 Section 490.203 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State Fleet Program § 490.203 Light Duty Alternative Fueled Vehicle Plan. (a) General Provisions...

  1. 76 FR 4637 - Taking and Importing Marine Mammals; U.S. Navy's Atlantic Fleet Active Sonar Training

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-26

    ... issuance of a Letter of Authorization; request for comments on Integrated Comprehensive Management Program... (Navy) to take marine mammals incidental to Navy training, maintenance, and research, development... notice that the Integrated Comprehensive Management Program (ICMP) Plan, which is intended for use as a...

  2. Probabilistic Guidance of Swarms using Sequential Convex Programming

    DTIC Science & Technology

    2014-01-01

    quadcopter fleet [24]. In this paper, sequential convex programming (SCP) [25] is implemented using model predictive control (MPC) to provide real-time...in order to make Problem 1 convex. The details for convexifying this problem can be found in [26]. The main steps are discretizing the problem using

  3. 10 CFR 611.2 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... average of the combined fuel economy of all vehicles in a fleet, which were subject to CAFE. Advanced... loan under this Program. CAFE means the Corporate Average Fuel Economy program of the Energy Policy and... gallon values, as are reported in accordance with section 32904 of title 49, United States Code. If CAFE...

  4. Path Planning Algorithms for the Adaptive Sensor Fleet

    NASA Technical Reports Server (NTRS)

    Stoneking, Eric; Hosler, Jeff

    2005-01-01

    The Adaptive Sensor Fleet (ASF) is a general purpose fleet management and planning system being developed by NASA in coordination with NOAA. The current mission of ASF is to provide the capability for autonomous cooperative survey and sampling of dynamic oceanographic phenomena such as current systems and algae blooms. Each ASF vessel is a software model that represents a real world platform that carries a variety of sensors. The OASIS platform will provide the first physical vessel, outfitted with the systems and payloads necessary to execute the oceanographic observations described in this paper. The ASF architecture is being designed for extensibility to accommodate heterogenous fleet elements, and is not limited to using the OASIS platform to acquire data. This paper describes the path planning algorithms developed for the acquisition phase of a typical ASF task. Given a polygonal target region to be surveyed, the region is subdivided according to the number of vessels in the fleet. The subdivision algorithm seeks a solution in which all subregions have equal area and minimum mean radius. Once the subregions are defined, a dynamic programming method is used to find a minimum-time path for each vessel from its initial position to its assigned region. This path plan includes the effects of water currents as well as avoidance of known obstacles. A fleet-level planning algorithm then shuffles the individual vessel assignments to find the overall solution which puts all vessels in their assigned regions in the minimum time. This shuffle algorithm may be described as a process of elimination on the sorted list of permutations of a cost matrix. All these path planning algorithms are facilitated by discretizing the region of interest onto a hexagonal tiling.

  5. A Short Guide for Aviation Resources for Community College Libraries

    ERIC Educational Resources Information Center

    Cunningham, Jim

    2009-01-01

    Community colleges are often venues for flight training programs. Since such programs are often housed off-campus at a local airport, the library may not even be aware of their existence. These programs range from small single courses done in conjunction with a local airport to full-fledged varieties with a fleet of aircraft owned by the college.…

  6. Coastal flooding impact evaluation using an INtegrated DisRuption Assessment (INDRA) model for Varna region, Western Black Sea

    NASA Astrophysics Data System (ADS)

    Andreeva, Nataliya; Eftimova, Petya; Valchev, Nikolay; Prodanov, Bogdan

    2017-04-01

    The study presents evaluation and comparative analysis of storm induced flooding impacts on different coastal receptors at a scale of Varna region using INtegrated DisRuption Assessment (INDRA) model. The model was developed within the FP7 RISC-KIT project, as a part of Coastal Risk Assessment Framework (CRAF) consisting of two phases. CRAF Phase 1 is a screening process that evaluates coastal risk at a regional scale by means of coastal indices approach, which helps to identify potentially vulnerable coastal sectors: hot spots (HS). CRAF Phase 2 has the objective to assess and rank identified hotspots by detailed risk analysis done by jointly performing a hazard assessment and an impact evaluation on different categories (population, businesses, ecosystems, transport and utilities) using INDRA model at a regional level. Basically, the model assess the shock of events by estimating the impact on directly exposed to flooding hazard receptors of different vulnerability, as well as the potential ripple effects during an event in order to assess the "indirect" impacts, which occur outside the hazard area and/or continue after the event for all considered categories. The potential impacts are expressed in terms of uniform "Impact Indicators", which independently score the indirect impacts of these categories assessing disruption and recovery of the receptors. The ultimate hotspot ranking is obtained through the use of a Multi Criteria analysis (MCA) incorporated in the model, considering preferences of stakeholders. The case study area - Varna regional coast - is located on the western Black Sea, Bulgaria. The coastline, with a length of about 70 km, stretches from cape Ekrene to cape St. Atanas and includes Varna Bay. After application of CRAF Phase 1 three hotspots were selected for further analysis: Kabakum beach (HS1), Varna Central beach plus Port wall (HS2) and Artificial Island (HS3). For first two hotspots beaches and associated infrastructure are the assets that attract holiday-makers and tourists in summer season. For HS3 the exposed area is occupied by storage premises for industrial goods and oil/fuel tanks. Flooding hazard was assessed through coupled use of XBeach 1D and LISFLOOD 2D inundation models at the selected hotspots. The "response" approach was adopted as 75 extreme storm events were simulated to obtain storm maxima series of overtopping discharges, flood depth, depth-velocity and berm retreat. The selected return periods within the extreme value analysis were 20, 50 and 100 years. For impact evaluation by INDRA model the categories "Population" and "Business" were considered. Impacts on Population were addressed by 3 impact indicators: "Risk to Life", "Household Displacement Time" and "Household Financial Recovery", while for Business category only by "Business Financial Recovery". Hotspots ranking was done using MCA by weighting of the evaluated indicators: focused on Risk to Life (F1) and on Business Financial Recovery (F2). MCA scoring focused on Household displacement/recovery was not evaluated because modelling results revealed quite a low number of flooded household receptors. Results show that for both F1 and F2 and for all considered return periods HS2 has the highest scores, which makes it a final hotspot.

  7. Real-time science and outreach from the UNOLS fleet via HiSeasNet

    NASA Astrophysics Data System (ADS)

    Foley, S.; Berger, J.; Orcutt, J. A.; Brice, D.; Coleman, D. F.; Grabowski, E. M.

    2010-12-01

    The HiSeasNet satellite communications network has ben providing cost-effective, reliable, continuous Internet connectivity to the UNOLS oceanographic research fleet for nearly nine years. During that time, HiSeasNet has supported science and outreach programs with a variety of real-time interactions back to shore including videoconferencing, webcasting, shared whiteboards, and streaming high-definition video feeds. Solutions have varied in scale, cost, and capability. As real-time science and outreach becomes more common, experience with a variety of technologies continues to build, and more opportunities yet to explore.

  8. 40 CFR 88.311-93 - Emissions standards for Inherently Low-Emission Vehicles.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (CONTINUED) AIR PROGRAMS (CONTINUED) CLEAN-FUEL VEHICLES Clean-Fuel Fleet Program § 88.311-93 Emissions... fuel vapor emissions which are five or less total grams per test as measured by the current Federal... control devices (canister, purge system, etc.) related to control of evaporative emissions, the fuel vapor...

  9. The atmospheric effects of stratospheric aircraft

    NASA Technical Reports Server (NTRS)

    Stolarski, Richard S. (Editor); Wesoky, Howard L. (Editor)

    1993-01-01

    This document presents a second report from the Atmospheric Effects of Stratospheric Aircraft (AESA) component of NASA's High-Speed Research Program (HSRP). This document presents a second report from the Atmospheric Effects of Stratospheric Aircraft (AESA) component of NASA's High Speed Research Program (HSRP). Market and technology considerations continue to provide an impetus for high-speed civil transport research. A recent United Nations Environment Program scientific assessment has shown that considerable uncertainty still exists about the possible impact of aircraft on the atmosphere. The AESA was designed to develop the body of scientific knowledge necessary for the evaluation of the impact of stratospheric aircraft on the atmosphere. The first Program report presented the basic objectives and plans for AESA. This second report presents the status of the ongoing research as reported by the principal investigators at the second annual AESA Program meeting in May 1992: Laboratory studies are probing the mechanism responsible for many of the heterogeneous reactions that occur on stratospheric particles. Understanding how the atmosphere redistributes aircraft exhaust is critical to our knowing where the perturbed air will go and for how long it will remain in the stratosphere. The assessment of fleet effects is dependent on the ability to develop scenarios which correctly simulate fleet operations.

  10. Motor carrier technology - fleet operational impacts and implications for ITS/CVO

    DOT National Transportation Integrated Search

    2000-03-01

    The Intelligent Transportation Systems/Commercial Vehicle Operations (ITS/CVO) Program is a cooperative effort between the Federal Motor Carrier Safety Administration (FMSCA), the Federal Highway Administration, States, Motor carriers, and other tran...

  11. Long non-coding RNA BANCR regulates cancer stem cell markers in papillary thyroid cancer via the RAF/MEK/ERK signaling pathway.

    PubMed

    Wang, Yuanyuan; Lin, Xiangde; Fu, Xinghao; Yan, Wei; Lin, Fusheng; Kuang, Penghao; Luo, Yezhe; Lin, Ende; Hong, Xiaoquan; Wu, Guoyang

    2018-06-18

    Thyroid cancer is one of the most common malignant tumors of the endocrine system. Among all thyroid cancers, papillary thyroid carcinoma (PTC) is the most common type. The BRAF-activated non-coding RNA (BANCR) is a 693-bp nucleotide transcript which was first identified in melanoma. However, the role of BANCR in the development of thyroid cancer remains unclear. Therefore, the present study investigated the potential involvement of BANCR in the development of thyroid cancer in vitro using patient tissue samples and a panel of thyroid cancer cell lines, and in vivo using a xenograft mouse model. We observed that BANCR was expressed at a higher level in human thyroid tumor tissues than that noted in the adjacent normal tissues. The expression level of BANCR differed between cultured thyroid cancer cell lines; BANCR expression was lower in the BCPAP cell line than that observed in the CAL-62, WRO and FTC-133 cell lines. Western blot analysis and flow cytometry revealed that overexpression of BANCR in the BCPAP cell line resulted in increased expression of the cancer stem cell markers, LGR5 and EpCAM. Single-clone formation experiments showed that upregulated expression of BANCR in the BCPAP cell line promoted an increase in the number of clones formed. Similarly, in microsphere formation experiments, overexpression of BANCR resulted in increased number and size of microspheres compared with the control cell line. Western blotting experiments showed that BANCR overexpression in BCPAP upregulated the expression of phosphorylated c-Raf, MEK1/2 and ERK1/2. Inhibition of c-Raf via U0126 decreased the expression of LGR5 and EpCAM, as well as phosphorylated levels of c-Raf, MEK1/2 and ERK1/2 in the BCPAP cells, compared to levels in the DMSO controls. In the xenograft mouse model, BANCR overexpression in the thyroid cancer cells significantly increased tumor growth. Taken together, these results suggest that BANCR plays a role in PTC development by regulating the expression of cancer stem cell markers LGR5 and EpCAM via the c-Raf/MEK/ERK signaling pathway. Therefore, BANCR may be used as a novel prognostic marker for PTC.

  12. An Optimization-Based Approach to Determine Requirements and Aircraft Design under Multi-domain Uncertainties

    NASA Astrophysics Data System (ADS)

    Govindaraju, Parithi

    Determining the optimal requirements for and design variable values of new systems, which operate along with existing systems to provide a set of overarching capabilities, as a single task is challenging due to the highly interconnected effects that setting requirements on a new system's design can have on how an operator uses this newly designed system. This task of determining the requirements and the design variable values becomes even more difficult because of the presence of uncertainties in the new system design and in the operational environment. This research proposed and investigated aspects of a framework that generates optimum design requirements of new, yet-to-be-designed systems that, when operating alongside other systems, will optimize fleet-level objectives while considering the effects of various uncertainties. Specifically, this research effort addresses the issues of uncertainty in the design of the new system through reliability-based design optimization methods, and uncertainty in the operations of the fleet through descriptive sampling methods and robust optimization formulations. In this context, fleet-level performance metrics result from using the new system alongside other systems to accomplish an overarching objective or mission. This approach treats the design requirements of a new system as decision variables in an optimization problem formulation that a user in the position of making an acquisition decision could solve. This solution would indicate the best new system requirements-and an associated description of the best possible design variable variables for that new system-to optimize the fleet level performance metric(s). Using a problem motivated by recorded operations of the United States Air Force Air Mobility Command for illustration, the approach is demonstrated first for a simplified problem that only considers demand uncertainties in the service network and the proposed methodology is used to identify the optimal design requirements and optimal aircraft sizing variables of new, yet-to-be-introduced aircraft. With this new aircraft serving alongside other existing aircraft, the fleet of aircraft satisfy the desired demand for cargo transportation, while maximizing fleet productivity and minimizing fuel consumption via a multi-objective problem formulation. The approach is then extended to handle uncertainties in both the design of the new system and in the operations of the fleet. The propagation of uncertainties associated with the conceptual design of the new aircraft to the uncertainties associated with the subsequent operations of the new and existing aircraft in the fleet presents some unique challenges. A computationally tractable hybrid robust counterpart formulation efficiently handles the confluence of the two types of domain-specific uncertainties. This hybrid formulation is tested on a larger route network problem to demonstrate the scalability of the approach. Following the presentation of the results obtained, a summary discussion indicates how decision-makers might use these results to set requirements for new aircraft that meet operational needs while balancing the environmental impact of the fleet with fleet-level performance. Comparing the solutions from the uncertainty-based and deterministic formulations via a posteriori analysis demonstrates the efficacy of the robust and reliability-based optimization formulations in addressing the different domain-specific uncertainties. Results suggest that the aircraft design requirements and design description determined through the hybrid robust counterpart formulation approach differ from solutions obtained from the simplistic deterministic approach, and leads to greater fleet-level fuel savings, when subjected to real-world uncertain scenarios (more robust to uncertainty). The research, though applied to a specific air cargo application, is technically agnostic in nature and can be applied to other facets of policy and acquisition management, to explore capability trade spaces for different vehicle systems, mitigate risks, define policy and potentially generate better returns on investment. Other domains relevant to policy and acquisition decisions could utilize the problem formulation and solution approach proposed in this dissertation provided that the problem can be split into a non-linear programming problem to describe the new system sizing and the fleet operations problem can be posed as a linear/integer programming problem.

  13. 40 CFR Appendix - Tables to Subpart C of Part 88

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 21 2013-07-01 2013-07-01 false Tables to Subpart C of Part 88 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CLEAN-FUEL VEHICLES Clean-Fuel Fleet Program Incentives for the purchase of Inherently Low-Emission Vehicles. Pt. 88, Subpt. C, Tables Tables to Subpart C of Par...

  14. 40 CFR Appendix - Tables to Subpart C of Part 88

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Tables to Subpart C of Part 88 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CLEAN-FUEL VEHICLES Clean-Fuel Fleet Program Incentives for the purchase of Inherently Low-Emission Vehicles. Pt. 88, Subpt. C, Tables Tables to Subpart C of Par...

  15. 40 CFR Appendix - Tables to Subpart C of Part 88

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 20 2011-07-01 2011-07-01 false Tables to Subpart C of Part 88 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CLEAN-FUEL VEHICLES Clean-Fuel Fleet Program Incentives for the purchase of Inherently Low-Emission Vehicles. Pt. 88, Subpt. C, Tables Tables to Subpart C of Par...

  16. 40 CFR Appendix - Tables to Subpart C of Part 88

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 20 2014-07-01 2013-07-01 true Tables to Subpart C of Part 88 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CLEAN-FUEL VEHICLES Clean-Fuel Fleet Program Incentives for the purchase of Inherently Low-Emission Vehicles. Pt. 88, Subpt. C, Tables Tables to Subpart C of Part...

  17. 40 CFR Appendix - Tables to Subpart C of Part 88

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 21 2012-07-01 2012-07-01 false Tables to Subpart C of Part 88 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CLEAN-FUEL VEHICLES Clean-Fuel Fleet Program Incentives for the purchase of Inherently Low-Emission Vehicles. Pt. 88, Subpt. C, Tables Tables to Subpart C of Par...

  18. How to Cut Costs by Saving School Bus Fuel.

    ERIC Educational Resources Information Center

    Seiff, Hank

    A program started in Washington County, Maryland in 1980 has been successful in saving school bus fuel and bringing down transportation costs incurred by its fleet of 200 buses. Driver training and motivation, as well as a partial transfer to diesel buses, are at the heart of the program. The drivers are taught five fuel saving techniques: cut…

  19. Virtual Impact: Leveraging Citizen Airmen’s Complementary Skills For Increased Cyber Mission Effectiveness

    DTIC Science & Technology

    2013-05-01

    A well-regulated militia was advocated by Washington, Jefferson, and Madison, and attempts were made to enable a law to insure an effective...Shadow Warriors: OSS and the Origins of the CIA, 11–12, 15, 21. The now known to be myth of Germany fifth column activities were persuasive enough...contractually, yet re-sell their CRAF flights. The combined impacts of deregulation and corporate financing require predictability in the “fixed buy

  20. IUE observations of periodic comets Tempel-2, Kopff, and Tempel-1

    NASA Technical Reports Server (NTRS)

    Feldman, Paul D.; Festou, Michel C.

    1992-01-01

    We summarize the results of observations made between 10 Jun. - 18 Dec. 1988 with the International Ultraviolet Explorer (IUS) of comet P/Tempel-2 during its 1988 appearance. The derived water production rate and relative gas/dust ratio are compared with those of P/Halley, observed with IUE in 1985-86, and other potential Comet Rendezvous/Asteroid Flyby (CRAF) target comets, P/Kopff and P/Tempel-1, both observed with IUE in 1983.

  1. Modeling tandem AAG8-MEK inhibition in melanoma cells

    PubMed Central

    Sun, Bing; Kawahara, Masahiro; Nagamune, Teruyuki

    2014-01-01

    Drug resistance presents a challenge to the treatment of cancer patients, especially for melanomas, most of which are caused by the hyperactivation of MAPK signaling pathway. Innate or acquired drug-resistant relapse calls for the investigation of the resistant mechanisms and new anti-cancer drugs to provide implications for the ultimate goal of curative therapy. Aging-associated gene 8 (AAG8, encoded by the SIGMAR1 gene) is a chaperone protein profoundly elaborated in neurology. However, roles of AAG8 in carcinogenesis remain unclear. Herein, we discover AAG8 antagonists as new MEK inhibitors in melanoma cells and propose a novel drug combination strategy for melanoma therapy by presenting the experimental evidences. We report that specific antagonism of AAG8, efficiently suppresses melanoma cell growth and migration through, at least in part, the inactivation of the RAS-CRAF-MEK signaling pathway. We further demonstrate that melanoma cells that are resistant to AAG8 antagonist harbor refractory CRAF-MEK activity. MEK acts as a central mediator for anti-cancer effects and also for the resistance mechanism, leading to our proposal of tandem AAG8-MEK inhibition in melanoma cells. Combination of AAG8 antagonist and very low concentration of a MEK inhibitor synergistically restricts the growth of drug-resistant cells. These data collectively pinpoint AAG8 as a potential target and delineate a promising drug combination strategy for melanoma therapy. PMID:24634165

  2. Malaria vaccine research.

    PubMed

    Ballou, W R; Diggs, C L; Landry, S; Hall, B F

    1994-12-16

    In our report "Activation of Raf as a result of recruitment to the plasma membrane" (3 June, p. 1463) (1), panels E and F of figure 1 on page 1464 were incorrect. The correct photographs appear below. In addition, the [See figure in the PDF file] second sentence of the legend to figure 1 should have read, "The Raf constructs were tagged at the COOH-terminus with a Glu-Glu epitope (MEYMPME) (24) for c-Raf, or at the NH(2)-terminus with both the Glu-Glu and the Myc (MEQKLISEEDL) (23) epitopes for RafCAAX"; the next-to-the-last sentence of the legend to figure 1 should have read, "The c-Raf constructs in (A through D) are Glu-Glu-tagged and were detected by using an anti Glu-Glu antibody, and the RafCAAX and Raf6QCAAX constructs used in E and F were detected by using the antibody to Raf COOH-terminal peptide"; and the third sentence of note 26 should have read, "After blocking with 5% milk in phosphate-buffered saline (M-PBS), cells were incubated with a mouse monoclonal antibody to Glu-Glu or a rabbit polyclonal antibody to a 20-amino acid COOH-terminal peptide of Raf-1 (Santa Cruz Biotechnology, Santa Cruz, California), washed, and incubated with donkey antibodies to mouse or rabbit IgG combined with Texas Red (Jackson) in M-PBS, washed, and mounted in FITC-Guard (Testog)."

  3. Alternative fuelds in urban fleets

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lindsay, T.

    1994-12-31

    In this presentation the author addresses four main objectives. They are to: discuss programs that are driving the introduction of alternative fuels into fleet operations in urban areas around the country; define alternative fuels; quantify the present use and future projections on alternative fuel vehicles (AVFs) in the Chicago metropolitan statistical area; and discuss benefits of increased use of alternative fuels in urban areas. Factors which touch on these points include: present domestic dependence on petroleum for autos, with usage exceeding production; the large populations in urban areas which do not meet Clean Air Standards; recent legislative initiatives which givemore » guidance and aid in the adoption of such strategies.« less

  4. Assessment of the Effects of High-Speed Aircraft in the Stratosphere: 1998

    NASA Technical Reports Server (NTRS)

    Kawa, S. Randolph; Anderson, James G.; Baughcum, Steven L.; Brock, Charles A.; Brune, William H.; Cohen, Ronald C.; Kinnison, Douglas E.; Newman, Paul A.; Rodriquez, Jose M.; Stolarski, Richard S.; hide

    1999-01-01

    This report assesses the potential atmospheric impacts of a proposed fleet of high-speed civil transport (HSCT) aircraft. The purpose of the report is to assess the effects of HSCT's on atmospheric composition and climate in order to provide a scientific basis for making technical, commercial, and environmental policy decisions regarding the HSCT fleet. The work summarized here was carried out as part of NASA's Atmospheric Effects of Aviation Project (a component of the High-Speed Research Program) as well as other NASA, U.S., and international research programs. The principal focus is on change in stratospheric ozone concentrations. The impact on climate change is also a concern. The report describes progress in understanding atmospheric processes, the current state of understanding of HSCT emissions, numerical model predictions of HSCT impacts, the principal uncertainties in atmospheric predictions, and the associated sensitivities in predicted effects of HSCT's.

  5. Assessment of the Effects of High-Speed Aircraft in the Stratosphere: 1998

    NASA Technical Reports Server (NTRS)

    Kawa, S. Randolph; Anderson, James G.; Baughcum, Steven L.; Brock, Charles A.; Brune, William H.; Cohen, Ronald C.; Kinnison, Douglas E.; Newman, Paul A.; Rodriguez, Jose M.; Stolarski, Richard S.; hide

    1999-01-01

    This report assesses the potential atmospheric impacts of a proposed fleet of high-speed civil transport (HSCT) aircraft. The purpose of the report is to assess the effects of HSCT's on atmospheric composition and climate in order to provide a scientific basis for making technical, commercial, and environmental policy decisions regarding the HSCT fleet. The work summarized here was carried out as part of NASA's Atmospheric Effects of Aviation Project (a component of the High-Speed Research Program) as well as other NASA, U.S., and international research programs. The principal focus is on change in stratospheric ozone concentrations. The impact on climate change is also a concern. The report describes progress in understanding atmospheric processes, the current state of understanding of HSCT emissions, numerical model predictions of HSCT impacts, the principal uncertainties in atmospheric predictions, and the associated sensitivities in predicted effects of HSCT'S.

  6. Underride safety protection: benefit-cost assessment of rear-impact guards for the North Dakota farm truck fleet.

    PubMed

    Vachal, Kimberly; Tumuhairwe, Esther K; Berwick, Mark

    2009-04-01

    The North Dakota Legislature recently passed a law exempting the state's agricultural truck fleet from a federal safety program requirement for rear-guard equipment on large trucks. This equipment has been shown to reduce crash severity when a passenger vehicle collides with the rear of the truck. This study uses truck fleet, truck crash, and injury severity data to estimate the public safety benefit derived from passenger-vehicle underride protection during rear-end crashes involving large agricultural trucks in North Dakota. A benefit-cost analysis of crash injury avoidance is developed based on the frequency and severity of rear-end truck collisions in North Dakota between 2001 and 2007. The injury avoidance benefits and commercial vehicle safety grant benefits are estimated to be $11.4 to $20.2 million during the seven-year depreciable truck life. The public safety benefits for rear-impact guards are higher than the estimated lifetime cost for the equipment and maintenance of $8.1 million.

  7. In-Use Fleet Evaluation of Fast-Charge Battery Electric Transit Buses

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Prohaska, Robert; Kelly, Kenneth; Eudy

    2016-06-27

    With support from the U.S. Department of Energy's Vehicle Technologies Office, the National Renewable Energy Laboratory (NREL) conducts real-world performance evaluations of advanced medium- and heavy-duty fleet vehicles. Evaluation results can help vehicle manufacturers fine-tune their designs and assist fleet managers in selecting fuel-efficient, low-emission vehicles that meet their economic and operational goals. In 2015, NREL launched an in-service evaluation of 12 battery electric buses (BEBs) compared to conventional compressed natural gas (CNG) buses operated by Foothill Transit in West Covina, California. The study aims to improve understanding of the overall usage and effectiveness of fast-charge BEBs and associated chargingmore » infrastructure in transit operation. To date, NREL researchers have analyzed more than 148,000 km of in-use operational data, including driving and charging events. Foothill Transit purchased the BEBs with grant funding from the Federal Transit Administration's Transit Investments for Greenhouse Gas and Energy Reduction Program.« less

  8. The Potential Impact of Collaborative and Three-Dimensional Imaging Technology on SHIPMAIN Fleet Modernization Plan

    DTIC Science & Technology

    2008-01-01

    Degree in Business Administration and was commissioned an Ensign in April of 2002 via the Inservice Procurement Program. LT Seaman reported for duty as...Florida for duty as an instructor/trainer and ran the Emergency Medical Technician training program and served as an Affiliate Faculty for the American...Heart Association’s Basic Life Support Program. Through the Inservice Procurement Program, he was commissioned as an Ensign in the Medical Service

  9. The Potential Impact of Collaborative and Three-dimensional Imaging Technology on SHIPMAIN Fleet Modernization Plan

    DTIC Science & Technology

    2007-10-26

    Ensign in April of 2002 via the Inservice Procurement Program. LT Seaman reported for duty as a staff hospital corpsman assigned to Naval Hospital Camp...Emergency Medical Technician training program and served as an Affiliate Faculty for the American Heart Association’s Basic Life Support Program. Through...the Inservice Procurement Program, he was commissioned as an Ensign in the Medical Service Corps in April of 2002 and completed Officer

  10. 41 CFR 102-34.330 - What is the Federal Fleet Report?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Fleet Report? 102-34.330 Section 102-34.330 Public Contracts and Property Management Federal Property... MANAGEMENT Federal Fleet Report § 102-34.330 What is the Federal Fleet Report? The Federal Fleet Report (FFR..., in evaluating the effectiveness of the operation and management of individual fleets to determine...

  11. Effects of diesel particle filter retrofits and accelerated fleet turnover on drayage truck emissions at the Port of Oakland.

    PubMed

    Dallmann, Timothy R; Harley, Robert A; Kirchstetter, Thomas W

    2011-12-15

    Heavy-duty diesel drayage trucks have a disproportionate impact on the air quality of communities surrounding major freight-handling facilities. In an attempt to mitigate this impact, the state of California has mandated new emission control requirements for drayage trucks accessing ports and rail yards in the state beginning in 2010. This control rule prompted an accelerated diesel particle filter (DPF) retrofit and truck replacement program at the Port of Oakland. The impact of this program was evaluated by measuring emission factor distributions for diesel trucks operating at the Port of Oakland prior to and following the implementation of the emission control rule. Emission factors for black carbon (BC) and oxides of nitrogen (NO(x)) were quantified in terms of grams of pollutant emitted per kilogram of fuel burned using a carbon balance method. Concentrations of these species along with carbon dioxide were measured in the exhaust plumes of individual diesel trucks as they drove by en route to the Port. A comparison of emissions measured before and after the implementation of the truck retrofit/replacement rule shows a 54 ± 11% reduction in the fleet-average BC emission factor, accompanied by a shift to a more highly skewed emission factor distribution. Although only particulate matter mass reductions were required in the first year of the program, a significant reduction in the fleet-average NO(x) emission factor (41 ± 5%) was observed, most likely due to the replacement of older trucks with new ones.

  12. 76 FR 38620 - International Fisheries; Atlantic Highly Migratory Species; Bluefin Tuna Import, Export, Re-Export

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-01

    ...: Libya's inability to participate in the ICCAT regional observer program this year as confirmed by the... the bluefin tuna fishery. Thus, any product taken by Libya's purse seine fleet under these conditions...

  13. Transition to Glass: Pilot Training for High-Technology Transport Aircraft

    NASA Technical Reports Server (NTRS)

    Wiener, Earl L.; Chute, Rebecca D.; Moses, John H.

    1999-01-01

    This report examines the activities of a major commercial air carrier between 1993 and late 1996 as it acquired an advanced fleet of high-technology aircraft (Boeing 757). Previously, the airline's fleet consisted of traditional (non-glass) aircraft, and this report examines the transition from a traditional fleet to a glass one. A total of 150 pilots who were entering the B-757 transition training volunteered for the study, which consisted of three query phases: (1) first day of transition training, (2) 3 to 4 months after transition training, and (3) 12 to 14 months after initial operating experience. Of these initial 150 pilots, 99 completed all three phases of the study, with each phase consisting of probes on attitudes and experiences associated with their training and eventual transition to flying the line. In addition to the three questionnaires, 20 in-depth interviews were conducted. Although the primary focus of this study was on the flight training program, additional factors such as technical support, documentation, and training aids were investigated as well. The findings generally indicate that the pilot volunteers were highly motivated and very enthusiastic about their training program. In addition, the group had low levels of apprehension toward automation and expressed a high degree of satisfaction toward their training. However, there were some concerns expressed regarding the deficiencies in some of the training aids and lack of a free-play flight management system training device.

  14. Cost/Benefit Evaluation of Three English Language Training Programs for Potential Navy Use.

    ERIC Educational Resources Information Center

    Swope, William M.; And Others

    As part of its plans to recruit Hispanic personnel who speak English as a second language, the U.S. Navy will have to provide English language training as well as technical training to prepare these personnel for fleet duty. A cost/benefit analysis was conducted of three English language training programs: the English Technical Language School…

  15. Naval Reserve Medicine: Recruitment Difficulties in the Medical Corps

    DTIC Science & Technology

    2016-03-01

    Reserve Naval Nurse Corps ..............24  4.  Evaluating the Effectiveness of Navy Medical Corps Accession Programs...the Navy EMF Expeditionary Medical Facility FTS Full Time Support GME Graduate Medical Education HPSP Health Professions Scholarship Program IDT...A. BACKGROUND The Department of the Navy (DON) provides operational support to the fleet by ensuring a sufficient number of medical professionals

  16. Aircraft noise prediction program validation

    NASA Technical Reports Server (NTRS)

    Shivashankara, B. N.

    1980-01-01

    A modular computer program (ANOPP) for predicting aircraft flyover and sideline noise was developed. A high quality flyover noise data base for aircraft that are representative of the U.S. commercial fleet was assembled. The accuracy of ANOPP with respect to the data base was determined. The data for source and propagation effects were analyzed and suggestions for improvements to the prediction methodology are given.

  17. Functional Proteomic Analysis of Signaling Networks and Response to Targeted Therapy

    DTIC Science & Technology

    2008-03-01

    of biochemical networks. Trends Biochemical Sci 31: 284–291. 56. Blinov ML, Faeder JR, Goldstein B , Hlavacek WS (2006) A network model of early events...activation is dependent on the nature of connectivity of the two receptors to B -Raf and C-Raf, which form a partially incoherent bifan. The incoherent bifan...Wooster, R., Stratton, M. R., and Futreal, P. A. (2002) Mutations of the BRaf gene in human cancer. Nature 417, 949–954 11. Goydos, J. S., Mann, B

  18. A New Age for Aerostats: Proving Airfield-Centric MANPADS Defense for Civil Aircraft Supporting Military Operations

    DTIC Science & Technology

    2010-04-01

    Maintaining Readiness, RAND Report MR-1506 (Santa Monica, CA: RAND, 2003, 58. 15 Graham, David R . Statement before the U.S. Congress Committee on...2. 19 Ibid., 4. 20 Ibid., 2. 21 Bolkcom, Christopher, CRAF, 9. 22 Graham, David R ., 3. 23 Cortez, Robert K. Statement before the U.S...Retrieved from http://www.state.gov/ r /pa/prs/ps/2009/july/126397.htm on 8 Dec 2009. 30 GlobalSecurity.org. “Man Portable Air Defense Systems (MANPADS

  19. An evaluation of the LPG vehicles program in the metropolitan area of Mexico City.

    PubMed

    Schifter, I; Díaz, L; López-Salinas, E; Rodríguez, R; Avalos, S; Guerrero, V

    2000-02-01

    The environmental agency in the metropolitan area of Mexico City has launched a program to introduce more energy-efficient modes of transport, one of which is the use of alternative and less polluting fuels. With the perspective in mind, a liquefied petroleum gas (LPG) fleet of vehicles is exempt of the mandatory "one day without a car" program if the emission of pollutants is below the standard authorized for that specific purpose. Today, about 28,000 light-duty vehicles and heavy-duty trucks circulate in the area, most of them as aftermarket converted vehicles. In this work, we evaluated regulated exhaust emission and other parameters on 134 representative vehicles of that fleet. From the data obtained, an estimate of emission factors and their contribution to the global emission in the metropolitan area is provided. It is concluded that more than 95% of the in-use vehicles using LPG presented regulated emissions which exceeded in one or more the environmental regulations values required for certification. The poor maintenance of the vehicles and the type of conversion kit installed could be the culprits of the results obtained.

  20. U.S. Coast Guard Pollution Abatement Program : Cutter Estimated Exhaust Emissions.

    DOT National Transportation Integrated Search

    1975-09-01

    The gaseous and particulate emissions of the Coast Guard cutter fleet are estimated by using measured emission factors and derived operational duty cycles. These data are compared to previous estimates by using emission factors found in the literatur...

  1. Cross-modal work helps OMC improve the safety of commercial transportation

    DOT National Transportation Integrated Search

    1997-01-01

    This article describes the Commercial Vehicle Information System (CVIS), designed to deploy a national safety program for the U.S. commercial trucking fleet. CVIS is built around a safety analysis algorithm called SafeStat which constructs a profile ...

  2. 40 CFR 52.351 - United States Postal Service substitute Clean Fuel Fleet Program.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... State Implementation Plan, carbon monoxide NAAQS, United States Postal Service substitute clean-fuel... of section 246 of the Clean Air Act for the Denver Metropolitan carbon monoxide nonattainment area.... [66 FR 64758, Dec. 14, 2001] ...

  3. Contributing Data to the Fleet DNA Project (Brochure)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    2014-09-01

    The Fleet DNA clearinghouse of commercial fleet transportation data helps vehicle manufacturers and developers optimize vehicle designs and helps fleet managers choose advanced technologies for their fleets. This online tool - available at www.nrel.gov/fleetdna - provides data summaries and visualizations similar to real-world 'genetics' for medium- and heavy-duty commercial fleet vehicles operating within a variety of vocations. To contribute your fleet data, please contact Adam Duran of the U.S. Department of Energy's National Renewable Energy Laboratory (NREL) at adam.duran@nrel.gov or 303-275-4586.

  4. Refueling Behavior of Flexible Fuel Vehicle Drivers in the Federal Fleet

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Daley, R.; Nangle, J.; Boeckman, G.

    2014-05-01

    Federal fleets are a frequent subject of legislative and executive efforts to lead a national transition to alternative fuels and advanced vehicle technologies. Section 701 of the Energy Policy Act of 2005 requires that all dual-fueled alternative fuel vehicles in the federal fleet be operated on alternative fuel 100% of the time when they have access to it. However, in Fiscal Year (FY) 2012, drivers of federal flex fuel vehicles (FFV) leased through the General Services Administration refueled with E85 24% of the time when it was available--falling well short of the mandate. The U.S. Department of Energy's National Renewablemore » Energy Laboratory completed a 2-year Laboratory Directed Research and Development project to identify the factors that influence the refueling behavior of federal FFV drivers. The project began with two primary hypotheses. First, information scarcity increases the tendency to miss opportunities to purchase E85. Second, even with perfect information, there are limits to how far drivers will go out of their way to purchase E85. This paper discusses the results of the project, which included a June 2012 survey of federal fleet drivers and an empirical analysis of actual refueling behavior from FY 2009 to 2012. This research will aid in the design and implementation of intervention programs aimed at increasing alternative fuel use and reducing petroleum consumption.« less

  5. 41 CFR 101-39.104-1 - Consolidations into a fleet management system.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... fleet management system. 101-39.104-1 Section 101-39.104-1 Public Contracts and Property Management..., TRANSPORTATION, AND MOTOR VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.1-Establishment, Modification, and Discontinuance of Interagency Fleet Management Systems § 101-39.104-1 Consolidations into a fleet management...

  6. An approach to the drone fleet survivability assessment based on a stochastic continues-time model

    NASA Astrophysics Data System (ADS)

    Kharchenko, Vyacheslav; Fesenko, Herman; Doukas, Nikos

    2017-09-01

    An approach and the algorithm to the drone fleet survivability assessment based on a stochastic continues-time model are proposed. The input data are the number of the drones, the drone fleet redundancy coefficient, the drone stability and restoration rate, the limit deviation from the norms of the drone fleet recovery, the drone fleet operational availability coefficient, the probability of the drone failure-free operation, time needed for performing the required tasks by the drone fleet. The ways for improving the recoverable drone fleet survivability taking into account amazing factors of system accident are suggested. Dependencies of the drone fleet survivability rate both on the drone stability and the number of the drones are analysed.

  7. 10 CFR 490.3 - Excluded vehicles.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false Excluded vehicles. 490.3 Section 490.3 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM General Provisions § 490.3... has a fleet or to calculate alternative fueled vehicle acquisition requirements, the following...

  8. 10 CFR 490.3 - Excluded vehicles.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 3 2014-01-01 2014-01-01 false Excluded vehicles. 490.3 Section 490.3 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM General Provisions § 490.3... has a fleet or to calculate alternative fueled vehicle acquisition requirements, the following...

  9. 10 CFR 490.3 - Excluded vehicles.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Excluded vehicles. 490.3 Section 490.3 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM General Provisions § 490.3... has a fleet or to calculate alternative fueled vehicle acquisition requirements, the following...

  10. 10 CFR 490.3 - Excluded vehicles.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 3 2012-01-01 2012-01-01 false Excluded vehicles. 490.3 Section 490.3 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM General Provisions § 490.3... has a fleet or to calculate alternative fueled vehicle acquisition requirements, the following...

  11. 10 CFR 490.3 - Excluded vehicles.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Excluded vehicles. 490.3 Section 490.3 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM General Provisions § 490.3... has a fleet or to calculate alternative fueled vehicle acquisition requirements, the following...

  12. Los Angeles congestion reduction demonstration (Metro ExpressLanes) program. National evaluation : cost benefit analysis test plan.

    DOT National Transportation Integrated Search

    1997-10-01

    The Federal Highway Administration (FHWA) commissioned this study to determine whether there are commercial vehicle fleet management needs that can be met through public sector involvement in the development of Intelligent Transportation Systems (ITS...

  13. Sustainability | NREL

    Science.gov Websites

    . Employees reduce mobile greenhouse gas emissions generated from commuting to work by biking to work instead infrastructure and programs significantly reduce petroleum use campus-wide via alternative fuel fleet vehicles goals like reducing mobile emissions by participating in alternative work schedules and using

  14. An Assessment of Operational Energy Capability Improvement Fund (OECIF) Programs 17-S-2544

    DTIC Science & Technology

    2017-09-19

    persistently attack key operational energy problems . OECIF themes are summarized in Table 1, and Appendix A includes more detail on the programs within... problems FY 2014 Analytical methods and tools FY 2015 Improving fuel economy for the current tactical ground fleet FY 2016 Increasing the operational...involve a variety of organizations to solve operational energy problems . In FY 2015, the OECIF program received a one-time $14.1M Congressional plus-up

  15. Advances in the Acquisition of Secure Systems Based on Open Architectures

    DTIC Science & Technology

    2011-04-30

    2011 11:15 a.m. – 12:45 p.m. Chair: Christopher Deegan , Executive Director, Program Executive Office for Integrated Warfare Systems Delivering...Systems Based on Open Architectures Walt Scacchi and Thomas Alspaugh, Institute for Software Research Christopher Deegan —Executive Director, Program...Executive Officer, Integrated Warfare Systems (PEO IWS). Mr. Deegan directs the development, acquisition, and fleet support of 150 combat weapon system

  16. 40 CFR 86.1861-04 - How do the Tier 2 and interim non-Tier 2 NOX averaging, banking and trading programs work?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 2 NOX averaging, banking and trading programs work? 86.1861-04 Section 86.1861-04 Protection of... work? (a) General provisions for Tier 2 credits and debits. (1) A manufacturer whose Tier 2 fleet... to a full useful life of 100,000 miles, provided that the credits are prorated by a multiplicative...

  17. Chinas Future SSBN Command and Control Structure

    DTIC Science & Technology

    2016-11-01

    ndupress.ndu.edu SF No. 299 1 China’s ongoing modernization program is transforming the country’s nuclear arsenal from one consisting of a few...also be mediated by bureaucratic poli- tics, including the time-honored tradition of interservice rivalry. The emergent SSBN fleet may represent a prime...represent a reliable source of resources. China has dedicated substantial resources to undertaking a nuclear modernization program designed to ensure

  18. Expanding the Telepresence Paradigm to the UNOLS Fleet

    NASA Astrophysics Data System (ADS)

    Coleman, D.; Scowcroft, G.

    2014-12-01

    The Inner Space Center (ISC) at the University of Rhode Island Graduate School of Oceanography (URI-GSO) has been at the forefront of developing the tools, techniques, and protocols for telepresence-enabled ocean science exploration and education programs. Working primarily with the Ocean Exploration Trust's E/V Nautilus and the NOAA Ship Okeanos Explorer, the ISC facility and staff have supported dozens of research cruises with significant shore-based support, while delivering related educational programming across the globe. Through a partnership with the University National Oceanographic Laboratory System (UNOLS), the ISC is broadening its reach and capabilities to serve vessels in the U.S. academic research fleet, managed by UNOLS. The ISC has developed and used a portable shipboard "mobile telepresence unit" (MTU) on several UNOLS ships to support projects led by ocean scientists that employed the telepresence paradigm as part of their research and outreach programs. Utilizing the ISC facilities provides opportunities for effective, successful broader impact activities and shore-based remote science connectivity. With new UNOLS ships coming online, including the R/V Sikuliaq, the R/V Neil Armstrong, and the R/V Sally Ride, in addition to future Regional Class Research Vessels (RCRVs), telepresence capability has become a technical requirement for a variety of reasons. Older vessels are being retrofit with this forward-looking technology, and URI's research vessel, the R/V Endeavor, has been recently configured with technology to support telepresence operations. This presentation will provide an overview of the future of telepresence technology, its use in ocean science research and education, and advantages for using this capability to support broader impact activities. In addition, ISC successes, challenges, and lessons learned in employing telepresence technologies and methodologies onboard the academic research fleet will be discussed.

  19. Modeling tandem AAG8-MEK inhibition in melanoma cells.

    PubMed

    Sun, Bing; Kawahara, Masahiro; Nagamune, Teruyuki

    2014-06-01

    Drug resistance presents a challenge to the treatment of cancer patients, especially for melanomas, most of which are caused by the hyperactivation of MAPK signaling pathway. Innate or acquired drug-resistant relapse calls for the investigation of the resistant mechanisms and new anti-cancer drugs to provide implications for the ultimate goal of curative therapy. Aging-associated gene 8 (AAG8, encoded by the SIGMAR1 gene) is a chaperone protein profoundly elaborated in neurology. However, roles of AAG8 in carcinogenesis remain unclear. Herein, we discover AAG8 antagonists as new MEK inhibitors in melanoma cells and propose a novel drug combination strategy for melanoma therapy by presenting the experimental evidences. We report that specific antagonism of AAG8, efficiently suppresses melanoma cell growth and migration through, at least in part, the inactivation of the RAS-CRAF-MEK signaling pathway. We further demonstrate that melanoma cells that are resistant to AAG8 antagonist harbor refractory CRAF-MEK activity. MEK acts as a central mediator for anti-cancer effects and also for the resistance mechanism, leading to our proposal of tandem AAG8-MEK inhibition in melanoma cells. Combination of AAG8 antagonist and very low concentration of a MEK inhibitor synergistically restricts the growth of drug-resistant cells. These data collectively pinpoint AAG8 as a potential target and delineate a promising drug combination strategy for melanoma therapy. © 2014 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

  20. Lowered expression of microRNA-125a-5p in human hepatocellular carcinoma and up-regulation of its oncogenic targets sirtuin-7, matrix metalloproteinase-11, and c-Raf

    PubMed Central

    Coppola, Nicola; de Stefano, Giorgio; Panella, Marta; Onorato, Lorenzo; Iodice, Valentina; Minichini, Carmine; Mosca, Nicola; Desiato, Luisa; Farella, Nunzia; Starace, Mario; Liorre, Giulia; Potenza, Nicoletta; Sagnelli, Evangelista; Russo, Aniello

    2017-01-01

    Human microRNA-125a-5p (miR-125a) is expressed in most tissues where it downregulates the expression of membrane receptors or intracellular transductors of mitogenic signals, thus limiting cell proliferation. Expression of this miRNA generally increases with cell differentiation whereas it is downregulated in several types of tumors, such as breast, lung, ovarian, gastric, colon, and cervical cancers, neuroblastoma, medulloblastoma, glioblastoma, and retinoblastoma. In this study, we focused on hepatocellular carcinoma and used real-time quantitative PCR to measure miR-125a expression in 55 tumor biopsies and in matched adjacent non-tumor liver tissues. This analysis showed a downregulation of miR-125a in 80 % of patients, with a mean decrease of 4.7-fold. Comparison of miRNA downregulation with clinicopathological parameters of patients didn't yield significant correlations except for serum bilirubin. We then evaluated the expression of known targets of miR-125a and found that sirtuin-7, matrix metalloproteinase-11, and c-Raf were up-regulated in tumor tissue by 2.2-, 3-, and 1.7-fold, respectively. Overall, these data support a tumor suppressor role for miR-125a and encourage further studies aimed at the comprehension of the molecular mechanisms governing its expression, eventually leading to treatments to restore its expression in tumor cells. PMID:28445974

  1. Executive Order 13514: Federal Leadership in Environmental, Energy, and Economic Performance; Comprehensive Federal Fleet Management Handbook (Book)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Daley, R.; Ahdieh, N.; Bentley, J.

    2014-01-01

    A comprehensive Federal Fleet Management Handbook that builds upon the "Guidance for Federal Agencies on E.O. 13514 Section 12-Federal Fleet Management" and provides information to help fleet managers select optimal greenhouse gas and petroleum reduction strategies for each location, meeting or exceeding related fleet requirements, acquiring vehicles to support these strategies while minimizing fleet size and vehicle miles traveled, and refining strategies based on agency performance.

  2. 48 CFR 51.204 - Use of interagency fleet management system (IFMS) vehicles and related services.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Contractor Use of Interagency Fleet Management System (IFMS) 51.204 Use of interagency fleet management system (IFMS) vehicles and related services. Contractors authorized to use interagency fleet management... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Use of interagency fleet...

  3. Cargo transportation by airships: a systems study. Final report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Huang, C.J.; Dalton, C.

    1976-05-01

    A systems engineering study of a lighter than air airship transportation system was conducted. The feasibility of the use of airships in hauling cargo was demonstrated. Social, legal, environmental and political factors were considered as well as the technical factors necessary to design an effective airship transportation system. In order to accomplish an effective airship transportation program two phases of implementation were recommended. Phase I would involve a fleet of rigid airships of 3.5 million cubic feet displacement capable of carrying 25 tons of cargo internal to the helium-filled gas bag. The Phase I fleet would demonstrate the economic andmore » technical feasibility of modern-day airships while providing a training capability for the construction and operation of larger airships. The Phase II portion would be a fleet of rigid airships of 12 million cubic feet displacement capable of carrying a cargo of 100 tons a distance of 2,000 miles at a cruising speed of 60 mph. An economic analysis is given for a variety of missions for both Phase I and Phase II airships.« less

  4. Cargo transportation by airships: A systems study

    NASA Technical Reports Server (NTRS)

    Huang, C. J.; Dalton, C.

    1976-01-01

    A systems engineering study of a lighter than air airship transportation system was conducted. The feasibility of the use of airships in hauling cargo was demonstrated. Social, legal, environmental and political factors were considered as well as the technical factors necessary to design an effective airship transportation system. In order to accomplish an effective airship transportation program two phases of implementation were recommended. Phase I would involve a fleet of rigid airships of 3.5 million cubic feet displacement capable of carrying 25 tons of cargo internal to the helium-filled gas bag. The Phase I fleet would demonstrate the economic and technical feasibility of modern-day airships while providing a training capability for the construction and operation of larger airships. The Phase II portion would be a fleet of rigid airships of 12 million cubic feet displacement capable of carrying a cargo of 100 tons a distance of 2,000 miles at a cruising speed of 60 mph. An economic analysis is given for a variety of missions for both Phase I and Phase II airships.

  5. 40 CFR 141.806 - Reporting requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... fleet; (ii) Change in status (active or inactive) of any aircraft as an aircraft water system as defined... to or removed from the water system. (iv) Change to whether the aircraft water system can be... Section 141.806 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS...

  6. 40 CFR 141.806 - Reporting requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... fleet; (ii) Change in status (active or inactive) of any aircraft as an aircraft water system as defined... to or removed from the water system. (iv) Change to whether the aircraft water system can be... Section 141.806 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS...

  7. USCG Pollution Abatement Program : A Preliminary Study of Vessel and Boat Exhaust Emissions

    DOT National Transportation Integrated Search

    1971-11-30

    A preliminary study of exhaust emissions from Coast Guard vessels and boats indicates that the Coast Guard fleet is an insignificant contributor to air pollution on a national and regional basis. Based upon fuel usage data, emission estimates by vess...

  8. 10 CFR 490.205 - Reporting requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 3 2014-01-01 2014-01-01 false Reporting requirements. 490.205 Section 490.205 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State Fleet... of new light duty alternative fueled vehicles that are required to be acquired during the model year...

  9. 10 CFR 490.205 - Reporting requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Reporting requirements. 490.205 Section 490.205 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State Fleet... of new light duty alternative fueled vehicles that are required to be acquired during the model year...

  10. 10 CFR 490.505 - Credit accounts.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false Credit accounts. 490.505 Section 490.505 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Fueled Vehicle... covered person who obtains an alternative fueled vehicle credit. (b) DOE shall send to each fleet and...

  11. 10 CFR 490.505 - Credit accounts.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 3 2012-01-01 2012-01-01 false Credit accounts. 490.505 Section 490.505 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Fueled Vehicle... covered person who obtains an alternative fueled vehicle credit. (b) DOE shall send to each fleet and...

  12. 10 CFR 490.505 - Credit accounts.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Credit accounts. 490.505 Section 490.505 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Fueled Vehicle... covered person who obtains an alternative fueled vehicle credit. (b) DOE shall send to each fleet and...

  13. 10 CFR 490.205 - Reporting requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 3 2012-01-01 2012-01-01 false Reporting requirements. 490.205 Section 490.205 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State Fleet... of new light duty alternative fueled vehicles that are required to be acquired during the model year...

  14. 10 CFR 490.205 - Reporting requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Reporting requirements. 490.205 Section 490.205 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State Fleet... of new light duty alternative fueled vehicles that are required to be acquired during the model year...

  15. 10 CFR 490.205 - Reporting requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false Reporting requirements. 490.205 Section 490.205 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State Fleet... of new light duty alternative fueled vehicles that are required to be acquired during the model year...

  16. 10 CFR 490.505 - Credit accounts.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 3 2014-01-01 2014-01-01 false Credit accounts. 490.505 Section 490.505 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Fueled Vehicle... covered person who obtains an alternative fueled vehicle credit. (b) DOE shall send to each fleet and...

  17. 10 CFR 490.505 - Credit accounts.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Credit accounts. 490.505 Section 490.505 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Fueled Vehicle... covered person who obtains an alternative fueled vehicle credit. (b) DOE shall send to each fleet and...

  18. Climatic Impact Assessment Program, Proceedings of the Survey Conference, February 15-16, 1972

    DOT National Transportation Integrated Search

    1972-09-01

    The report contains the proceedings of a survey conference, concerning the impact of climatic changes which might result from perturbation of the upper atmosphere by the exhaust effluent of a world high-altitude aircraft fleet, as projected to 1990. ...

  19. Development of a modal emissions model using data from the Cooperative Industry/Government Exhaust Emission test program

    DOT National Transportation Integrated Search

    2003-06-22

    The Environmental Protection Agencys (EPAs) recommended model, MOBILE5a, has been : used extensively to predict emission factors based on average speeds for each fleet type. : Because average speeds are not appropriate in modeling intersections...

  20. Evaporative Emissions from In-Use Vehicles: Test Fleet Expansion (CRC E-77-2b) Final Report

    EPA Pesticide Factsheets

    Report describes the ongoing investigation into the evaporative emission performance of aging light-duty vehicles. The objective was to add additional data to the Coordinating Research Council's (CRC) E-77-2 evaporative emission/permeation test program

  1. Material Issues in Space Shuttle Composite Overwrapped Pressure Vessels

    NASA Technical Reports Server (NTRS)

    Sutter, James K.; Jensen, Brian J.; Gates, Thomas S.; Morgan, Roger J.; Thesken, John C.; Phoenix, S. Leigh

    2006-01-01

    Composite Overwrapped Pressure Vessels (COPV) store gases used in four subsystems for NASA's Space Shuttle Fleet. While there are 24 COPV on each Orbiter ranging in size from 19-40", stress rupture failure of a pressurized Orbiter COPV on the ground or in flight is a catastrophic hazard and would likely lead to significant damage/loss of vehicle and/or life and is categorized as a Crit 1 failure. These vessels were manufactured during the late 1970's and into the early 1980's using Titanium liners, Kevlar 49 fiber, epoxy matrix resin, and polyurethane coating. The COPVs are pressurized periodically to 3-5ksi and therefore experience significant strain in the composite overwrap. Similar composite vessels were developed in a variety of DOE Programs (primarily at Lawrence Livermore National Laboratories or LLNL), as well as for NASA Space Shuttle Fleet Leader COPV program. The NASA Engineering Safety Center (NESC) formed an Independent Technical Assessment (ITA) team whose primary focus was to investigate whether or not enough composite life remained in the Shuttle COPV in order to provide a strategic rationale for continued COPV use aboard the Space Shuttle Fleet with the existing 25-year-old vessels. Several material science issues were examined and will be discussed in this presentation including morphological changes to Kevlar 49 fiber under stress, manufacturing changes in Kevlar 49 and their effect on morphology and tensile strength, epoxy resin strain, composite creep, degradation of polyurethane coatings, and Titanium yield characteristics.

  2. Initial development of a practical safety audit tool to assess fleet safety management practices.

    PubMed

    Mitchell, Rebecca; Friswell, Rena; Mooren, Lori

    2012-07-01

    Work-related vehicle crashes are a common cause of occupational injury. Yet, there are few studies that investigate management practices used for light vehicle fleets (i.e. vehicles less than 4.5 tonnes). One of the impediments to obtaining and sharing information on effective fleet safety management is the lack of an evidence-based, standardised measurement tool. This article describes the initial development of an audit tool to assess fleet safety management practices in light vehicle fleets. The audit tool was developed by triangulating information from a review of the literature on fleet safety management practices and from semi-structured interviews with 15 fleet managers and 21 fleet drivers. A preliminary useability assessment was conducted with 5 organisations. The audit tool assesses the management of fleet safety against five core categories: (1) management, systems and processes; (2) monitoring and assessment; (3) employee recruitment, training and education; (4) vehicle technology, selection and maintenance; and (5) vehicle journeys. Each of these core categories has between 1 and 3 sub-categories. Organisations are rated at one of 4 levels on each sub-category. The fleet safety management audit tool is designed to identify the extent to which fleet safety is managed in an organisation against best practice. It is intended that the audit tool be used to conduct audits within an organisation to provide an indicator of progress in managing fleet safety and to consistently benchmark performance against other organisations. Application of the tool by fleet safety researchers is now needed to inform its further development and refinement and to permit psychometric evaluation. Copyright © 2012 Elsevier Ltd. All rights reserved.

  3. U.S. Army Methanol-Fueled Administrative Vehicle Demonstration Program

    DTIC Science & Technology

    1989-08-01

    for either fuel when compared with published production specifications. iii Also, four Chevrolet vehicles, two each with L-4 engines and two with V-6...With Manufacturer’s Production Specifications ... 217 G CRC Deposit Ratings for Inspected Vehicles ...................... 235 Viii LIST OF ILLUSTRATIONS...vehicles within the Government’s administrative fleet and to stimulate further the production and use of methanol-fueled vehicles. This program was

  4. The atmospheric effects of stratospheric aircraft: A current consensus

    NASA Technical Reports Server (NTRS)

    Douglass, A. R.; Carroll, M. A.; Demore, W. B.; Holton, J. R.; Isaksen, I. S. A.; Johnston, H. S.; Ko, M. K. W.

    1991-01-01

    In the early 1970's, a fleet of supersonic aircraft flying in the lower stratosphere was proposed. A large fleet was never built for economic, political, and environmental reasons. Technological improvements may make it economically feasible to develop supersonic aircraft for current markets. Some key results of earlier scientific programs designed to assess the impact of aircraft emissions on stratospheric ozone are reviewed, and factors that must be considered to assess the environmental impact of aircraft exhaust are discussed. These include the amount of nitrogen oxides injected in the stratosphere, horizontal transport, and stratosphere/troposphere assessment models are presented. Areas in which improvements in scientific understanding and model representation must be made to reduce the uncertainty in model calculations are identified.

  5. The Application of Probabilistic Methods to the Mistuning Problem

    NASA Technical Reports Server (NTRS)

    Griffin, J. H.; Rossi, M. R.; Feiner, D. M.

    2004-01-01

    FMM is a reduced order model for efficiently calculating the forced response of a mistuned bladed disk. FMM ID is a companion program which determines the mistuning in a particular rotor. Together, these methods provide a way to acquire data on the mistuning in a population of bladed disks, and then simulate the forced response of the fleet. This process is tested experimentally, and the simulated results are compared with laboratory measurements of a fleet of test rotors. The method is shown to work quite well. It is found that accuracy of the results depends on two factors: the quality of the statistical model used to characterize mistuning, and how sensitive the system is to errors in the statistical modeling.

  6. Partners in Freedom: Contributions of the Langley Research Center to U.S. Military Aircraft of the 1990's

    NASA Technical Reports Server (NTRS)

    Chambers, Joseph R.

    2000-01-01

    Established in 1917 as the nation#s first civil aeronautics research laboratory under the National Advisory Commit-tee for Aeronautics (NACA), Langley was a small laboratory that solved the problems of flight for military and civil aviation. Throughout history, Langley has maintained a working partnership with the Department of Defense, U.S. industry, universities, and other government agencies to support the defense of the nation with research. During World War II, Langley directed virtually all of its workforce and facilities to research for military aircraft. Following the war, a balanced program of military and civil projects was undertaken. In some instances Langley research from one aircraft program helped solve a problem in another. At the conclusion of some programs, Langley obtained the research models for additional tests to learn more about previously unknown phenomena. The data also proved useful in later developmental programs. Many of the military aircraft in the U.S. inventory as of late 1999 were over 20 years old. Langley activities that contributed to the development of some of these aircraft began over 50 years prior. This publication documents the role, from early concept stages to problem solving for fleet aircraft, that Langley played in the military aircraft fleet of the United States for the 1990's.

  7. Monitoring Report - Automobile Voluntary Fuel Economy Improvement Program

    DOT National Transportation Integrated Search

    1976-04-01

    On October 8, 1974, President Ford announced the goal of a 40% improvement in fuel economy of automobiles to be achieved in the 1980 new car fleet compared to 14.0 MPH for 1974. The Secretary of Transportation was given the lead in developing the pro...

  8. Human factors evaluation of the work environment of operators engaged in the inspection and repair of aging aircraft.

    DOT National Transportation Integrated Search

    1992-01-01

    Site evaluations of air carriers and repair stations conducting inspections and heavy maintenance on PART 121 aging aircraft were conducted during 1989-90 under the FAA's Office of Flight Standards Aging Fleet Evaluation Program. This report presents...

  9. 76 FR 39771 - Special Local Regulations for Marine Events; Lake Gaston, Enterprise, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-07

    ..., Program Manager, Docket Operations, telephone 202-366-9826. SUPPLEMENTARY INFORMATION: Regulatory... the Waterview Restaurant. A fleet of spectator vessels are expected to gather near the event site to..., design, or operation; test methods; sampling procedures; and related management systems practices) that...

  10. Room To Grow? Facilities Programming for Colleges and Universities.

    ERIC Educational Resources Information Center

    Thompson, Roger; Adams, Tom

    2001-01-01

    Asserts that campus space needs could be remedied by moving centrally located service delivery organizations, such as fleet vehicle maintenance facilities. Describes the process of operational and space needs assessment; this process provides information that enables architects to plan for appropriate adjacencies, correct space allocation, and…

  11. 75 FR 74134 - State of Good Repair Bus and Bus Facilities Discretionary Program Funds

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-30

    ... public agencies, private companies engaged in public transportation, or private non-profit organizations... public transportation bus fleet, infrastructure, and equipment in a state of good repair. Grantees... DEPARTMENT OF TRANSPORTATION Federal Transit Administration State of Good Repair Bus and Bus...

  12. 10 CFR 490.805 - Application for waiver.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false Application for waiver. 490.805 Section 490.805 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Compliance § 490... alternative compliance and whether the fleet is in compliance with Clean Air Act vehicle emission standards...

  13. 10 CFR 490.805 - Application for waiver.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Application for waiver. 490.805 Section 490.805 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Compliance § 490... alternative compliance and whether the fleet is in compliance with Clean Air Act vehicle emission standards...

  14. 10 CFR 490.805 - Application for waiver.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 3 2014-01-01 2014-01-01 false Application for waiver. 490.805 Section 490.805 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Compliance § 490... alternative compliance and whether the fleet is in compliance with Clean Air Act vehicle emission standards...

  15. 10 CFR 490.805 - Application for waiver.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 3 2012-01-01 2012-01-01 false Application for waiver. 490.805 Section 490.805 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Compliance § 490... alternative compliance and whether the fleet is in compliance with Clean Air Act vehicle emission standards...

  16. 10 CFR 490.805 - Application for waiver.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Application for waiver. 490.805 Section 490.805 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Compliance § 490... alternative compliance and whether the fleet is in compliance with Clean Air Act vehicle emission standards...

  17. Alternative Fuels Data Center

    Science.gov Websites

    Light-Duty Alternative Fuel Vehicle Rebates Clean Vehicle and Infrastructure Grants Clean Fleet Grants Clean School Bus Program Clean Vehicle Replacement Vouchers Diesel Fuel Blend Tax Exemption Idle Reduction Weight Exemption Natural Gas Vehicle (NGV) Weight Exemption Utility/Private Incentives Plug-In

  18. 40 CFR 86.1866-12 - CO2 fleet average credit programs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... technologies designed to reduce air conditioning refrigerant leakage over the useful life of their passenger....1865-12 by implementing specific air conditioning system technologies designed to reduce air... performance improvement for the system of greater than 10% when compared to previous industry standard designs...

  19. 49 CFR 535.7 - Averaging, banking, and trading (ABT) program.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... averaging set. With the exception of FCC earned for advance technologies as further clarified below, a... transactions. Traded FCC, other than advanced technology credits, may be used by a manufacturer only within the... fleet includes conventional vehicles (gasoline, diesel and alternative fuel) and advanced technology...

  20. 49 CFR 535.7 - Averaging, banking, and trading (ABT) program.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... averaging set. With the exception of FCC earned for advance technologies as further clarified below, a... transactions. Traded FCC, other than advanced technology credits, may be used by a manufacturer only within the... fleet includes conventional vehicles (gasoline, diesel and alternative fuel) and advanced technology...

  1. Cometary Coma Chemical Composition (C4) Mission

    NASA Technical Reports Server (NTRS)

    Carle, Glenn C.; Clark, Benton C.; Knocke, Philip C.; OHara, Bonnie J.; Adams, Larry; Niemann, Hasso B.; Alexander, Merle; Veverka, Joseph; Goldstein, Raymond; Huebner, Walter; hide

    1994-01-01

    Cometary exploration remains of great importance to virtually all of space science. Because comets are presumed to be remnants of the early solar nebula, they are expected to provide fundamental knowledge as to the origin and development of the solar system as well as to be key to understanding of the source of volatiles and even life itself in the inner solar system. Clearly the time for a detailed study of the composition of these apparent messages from the past has come. A comet rendezvous mission, the Cometary Coma Chemical Composition (C4) Mission, is now being studied as a candidate for the new Discovery program. This mission is a highly-focussed and usefully-limited subset of the Cometary Rendezvous Asteroid Flyby (CRAF) Mission. The C4 mission will concentrate on measurements that will produce an understanding of the composition and physical makeup of a cometary nucleus. The core science goals of the C4 mission are 1) to determine the chemical, elemental, and isotopic composition of a cometary nucleus and 2) to characterize the chemical and isotopic nature of its atmosphere. A related goal is to obtain temporal information about the development of the cometary coma as a function of time and orbital position. The four short-period comets -- Tempel 1, Tempel 2, Churyumov-Gerasimenko, and Wirtanen -which all appear to have acceptable dust production rates, were identified as candidate targets. Mission opportunities have been identified beginning as early as 1998. Tempel I with a launch in 1999, however, remains the baseline comet for studies of and planning the C4 mission. The C4 mission incorporates two science instruments and two engineering instruments in the payload to obtain the desired measurements. The science instruments include an advanced version of the Cometary Ice and Dust Experiment (CIDEX), a mini-CIDEX with a sample collection system, an X-ray Fluorescence Spectrometer and a Pyrolysis-Gas Chromatograph, and a simplified version of the Neutral Gas and Ion Mass Spectrometer (NIGMS). Both of these instruments have substantial heritage as they are based on those developed for the CRAF Mission. The engineering instruments include a simplified Comet Dust Environmental Monitor (SCODEM) and a navigational Camera, NAVCAM. While neither of the instruments will be permitted to establish science requirements, it is anticipated that significant science return will be accomplished Radio science will also be included.

  2. Alternative Fuels Data Center: Santa Fe Metro Fleet Runs on Natural Gas

    Science.gov Websites

    Santa Fe Metro Fleet Runs on Natural Gas to someone by E-mail Share Alternative Fuels Data Center : Santa Fe Metro Fleet Runs on Natural Gas on Facebook Tweet about Alternative Fuels Data Center: Santa Fe Metro Fleet Runs on Natural Gas on Twitter Bookmark Alternative Fuels Data Center: Santa Fe Metro Fleet

  3. Financing commercial RLVs: Considering government incentives

    NASA Astrophysics Data System (ADS)

    Greenberg, Joel S.

    1997-01-01

    There appears to be a national goal to achieve a commercial space transportation industry that provides launch services utilizing a fleet of reusable launch vehicles (RLVs). Because of the combination of large required investment, inadequate rate of return, and perceived high risk, industry has indicated that this goal may not be achievable without government support. What form of government support will likely be necessary? Government programs and policies can effect private sector investment decisions by reducing risk perceptions, reducing capital requirements, and increasing expected rates of return. Different programs and policies will have different impacts. For example, tax policies will affect expected return on investment but are likely to have little or no effect on risk perceptions and magnitude of required investment, whereas anchor tenancy is likely to alter risk perceptions and may increase expected rates of return. This paper is concerned with the development of an approach that may be used to identify packages of government incentives that may be required to influence private sector investment decisions so as to achieve the desired goal of a commercial space transportation industry that provides launch services utilizing a fleet of RLVs. The paper discusses the relationship of government incentive programs and policies to the RLV investment decision.

  4. An investigation of rental rates for centralized fleet vehicles.

    DOT National Transportation Integrated Search

    1999-01-01

    This report details a study to investigate the current rental rate structure used by the Division of Fleet Management (Fleet Management) to charge state agencies for the use of centralized fleet vehicles. The researchers conducted a literature review...

  5. CleanFleet final report. Volume 8, fleet economics

    DOT National Transportation Integrated Search

    1995-12-01

    The costs that face a fleet operator in implementing alternative motor fuels : into fleet operations are examined. The cost assessment is built upon a list of thirteen cost factors grouped into the three catagories: infrastructure costs, vehicle owni...

  6. FleetDASH

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Singer, Mark R

    2017-09-06

    FleetDASH helps federal fleet managers maximize their use of alternative fuel. This presentation explains how the dashboard works and demonstrates the newest capabilities added to the tool. It also reviews complementary online tools available to fleet managers on the Alternative Fuel Data Center.

  7. 41 CFR 101-39.106 - Unlimited exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.1-Establishment, Modification, and Discontinuance of Interagency Fleet Management Systems § 101-39.106 Unlimited exemptions. Unlimited exemptions from inclusion in the fleet... below. Unlimited exemptions do not preclude agencies from requesting fleet management services, if...

  8. Increasing Fleet Readiness Through Improved Distance Support

    DTIC Science & Technology

    2013-03-01

    gis tic s D ata Pro ce ss  Tra ini ng  Da ta An aly ze  Da ta An...Format Fleet Maintenance Formatted Data /sData F.2.2 • ... Fleet Support Infrastructure Data ~ Formatted Trainin~ ata l Obtain and Format Fleet...system either by using a form or a spreadsheet F.2.2 Obtain Data from Fleet Recorded System Performance Data is downloaded from ship either manually

  9. Multi-vehicle mobility allowance shuttle transit (MAST) system : an analytical model to select the fleet size and a scheduling heuristic.

    DOT National Transportation Integrated Search

    2012-06-01

    The mobility allowance shuttle transit (MAST) system is a hybrid transit system in which vehicles are : allowed to deviate from a fixed route to serve flexible demand. A mixed integer programming (MIP) : formulation for the static scheduling problem ...

  10. 76 FR 68819 - State of Good Repair Bus and Bus Facilities Discretionary Program Funds

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-07

    ... that are public agencies, private companies engaged in public transportation, or private non-profit... Table 1 will provide funds to help maintain the nation's public transportation bus fleet, infrastructure... DEPARTMENT OF TRANSPORTATION Federal Transit Administration State of Good Repair Bus and Bus...

  11. 10 CFR 490.204 - Process for granting exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false Process for granting exemptions. 490.204 Section 490.204 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State...) Alternative fuels that meet the normal requirements and practices of the principal business of the State fleet...

  12. 10 CFR 490.204 - Process for granting exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 3 2014-01-01 2014-01-01 false Process for granting exemptions. 490.204 Section 490.204 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State...) Alternative fuels that meet the normal requirements and practices of the principal business of the State fleet...

  13. 10 CFR 490.204 - Process for granting exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 3 2012-01-01 2012-01-01 false Process for granting exemptions. 490.204 Section 490.204 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State...) Alternative fuels that meet the normal requirements and practices of the principal business of the State fleet...

  14. 10 CFR 490.204 - Process for granting exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Process for granting exemptions. 490.204 Section 490.204 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State...) Alternative fuels that meet the normal requirements and practices of the principal business of the State fleet...

  15. Medical Play in Kernel Blitz 󈨥: Findings and Recommendations

    DTIC Science & Technology

    1998-01-01

    telemedicine, the blood program, and oxygen. We include analyses of oxygen because in Kernel Blitz (KB) 󈨣 it was discovered that the LHA ran out of oxygen...and scabies ), the CEGs at some platforms did not complete a survey. We obtained surveys from the surgical company, the fleet hospital, Tarawa

  16. 10 CFR 490.703 - Biodiesel fuel use credit allocation.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 3 2012-01-01 2012-01-01 false Biodiesel fuel use credit allocation. 490.703 Section 490.703 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Biodiesel Fuel Use Credit § 490.703 Biodiesel fuel use credit allocation. (a) DOE shall allocate to a fleet or...

  17. 10 CFR 490.703 - Biodiesel fuel use credit allocation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false Biodiesel fuel use credit allocation. 490.703 Section 490.703 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Biodiesel Fuel Use Credit § 490.703 Biodiesel fuel use credit allocation. (a) DOE shall allocate to a fleet or...

  18. 10 CFR 490.703 - Biodiesel fuel use credit allocation.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false Biodiesel fuel use credit allocation. 490.703 Section 490.703 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Biodiesel Fuel Use Credit § 490.703 Biodiesel fuel use credit allocation. (a) DOE shall allocate to a fleet or...

  19. 10 CFR 490.703 - Biodiesel fuel use credit allocation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 3 2014-01-01 2014-01-01 false Biodiesel fuel use credit allocation. 490.703 Section 490.703 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Biodiesel Fuel Use Credit § 490.703 Biodiesel fuel use credit allocation. (a) DOE shall allocate to a fleet or...

  20. 10 CFR 490.703 - Biodiesel fuel use credit allocation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Biodiesel fuel use credit allocation. 490.703 Section 490.703 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Biodiesel Fuel Use Credit § 490.703 Biodiesel fuel use credit allocation. (a) DOE shall allocate to a fleet or...

  1. Navy Virginia (SSN 774) Class Attack Submarine Procurement: Background and Issues for Congress

    DTIC Science & Technology

    2016-04-14

    programs before the Seapower subcommittee of the Senate Armed Services Committee, the following exchange occurred: SENATOR KELLY AYOTTE (continuing... Bryan Bender, “Navy Eyes Cutting Submarine Force,” Boston Globe, May 12, 2004, p. 1; Lolita C. Baldor, “Study Recommends Cutting Submarine Fleet

  2. S/EV 1992: Solar and Electric Vehicles. Volume 1: Proceedings

    NASA Astrophysics Data System (ADS)

    These proceedings include the morning plenary sessions and then sessions on each of the following topics: Electric Vehicle (EV) fundamentals, advanced EV's, photovoltaics, policy, and fleets. Many individual topics are considered to include: EV races, environmental benefits, demonstration programs, lightweight composite materials, advanced components, and electric batteries.

  3. 40 CFR 86.1867-12 - Optional early CO2 credit programs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... efficiency credits, early advanced technology credits, and early off-cycle technology credits. Manufacturers... an approved value. (F) Carbon-related exhaust emission values for electric, fuel cell, and plug-in hybrid electric model types shall be included in the fleet average determined under paragraph (a)(1) of...

  4. 40 CFR 86.1871-12 - Optional early CO2 credit programs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... efficiency credits, early advanced technology credits, and early off-cycle technology credits. Manufacturers... manufacturer may use such an approved value. (F) Carbon-related exhaust emission values for electric, fuel cell, and plug-in hybrid electric model types shall be included in the fleet average determined under...

  5. 41 CFR 101-39.102 - Determinations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.1-Establishment, Modification, and Discontinuance of Interagency Fleet Management Systems § 101-39.102 Determinations. Each determination to establish a fleet management system... name of the executive agency designated to be responsible for operating the fleet management system and...

  6. Alternative fuel options and costs for use in Kansas and surrounding states

    DOT National Transportation Integrated Search

    1998-09-01

    To meet state and federal mandates, state fleets, federal fleets, and fuel provider fleets must acquire alternatively fueled vehicles (AFVs). The Kansas House Bill 95-2161 exceeds the federal energy policy act regulations for state fleets. AFVs inclu...

  7. National Clean Fleets Partnership (Fact Sheet)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None, None

    2014-01-01

    Clean Cities' National Clean Fleets Partnership establishes strategic alliances with large fleets to help them explore and adopt alternative fuels and fuel economy measures to cut petroleum use. The initiative leverages the strength of nearly 100 Clean Cities coalitions, nearly 18,000 stakeholders, and more than 20 years of experience. It provides fleets with top-level support, technical assistance, robust tools and resources, and public acknowledgement to help meet and celebrate fleets' petroleum-use reductions.

  8. Commercial vehicle fleet management and information systems. Technical memorandum 3 : ITS fleet management technology resource guide

    DOT National Transportation Integrated Search

    1997-05-01

    In todays increasingly competitive economic environment, effective management of commercial vehicle fleets is important for all types of carriers and for the trucking industry as a whole. To meet fleet management needs, carriers increasingly are t...

  9. 41 CFR 101-39.203 - Obtaining motor vehicles for short-term use.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., AND MOTOR VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.2-GSA Interagency Fleet Management... Fleet Management System (IFMS). Short-term use vehicles may be provided through Military Traffic... General Services Administration IFMS fleet management center. [56 FR 59888, Nov. 26, 1991] ...

  10. 41 CFR 101-39.202 - Contractor authorized services.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.2-GSA Interagency Fleet Management System Services... related GSA Interagency Fleet Management System (IFMS) services solely for official purposes. (b) To the... -leased equipment which is not controlled by a GSA IFMS fleet management center, or for authorized...

  11. 78 FR 23935 - Federal Acquisition Regulation; Information Collection; Contractor Use of Interagency Fleet...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-23

    ...; Information Collection; Contractor Use of Interagency Fleet Management System Vehicles AGENCY: Department of... previously approved information collection requirement concerning contractor use of interagency fleet... Collection 9000- 0032, Contractor Use of Interagency Fleet Management System Vehicles, by any of the...

  12. 78 FR 64499 - Federal Acquisition Regulation; Submission for OMB Review; Contractor Use of Interagency Fleet...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-29

    ...; Submission for OMB Review; Contractor Use of Interagency Fleet Management System Vehicles AGENCY: Department... previously approved information collection requirement concerning contractor use of interagency fleet... comments identified by Information Collection 9000- 0032, Contractor Use of Interagency Fleet Management...

  13. U. S. Navy’s Superconductivity Programs; Scientific Curosity To Fleet Utility

    DTIC Science & Technology

    2010-10-01

    NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND...ADDRESS(ES) Naval Research Laboratory,Washington,DC,20375 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS...classes of materials studied for superconductivity were ternary alloys13, and organic materials14. The dilution refrigerator largely replaced

  14. Role of U.S. Security Assistance in Modernizing the Portuguese Armed Forces: A Historical Analysis.

    DTIC Science & Technology

    1986-09-01

    Portuguese Air Force Fiscal Year 1986 IMET/FMS Training Program Security Assistance Management Manual * "Portuguese Navy: A Naval Fleet that is...of the techniques of fiscal management and, within the limits that he had set for the regime, his program of economic recovery succeeded .... What...1984). Currency: Escudo * Agriculture: generally developed; 8.8,% of GDP; main crops - grains, potatoes, olives, grapes (wine); deficit foods - sugar

  15. An optimization method for condition based maintenance of aircraft fleet considering prognostics uncertainty.

    PubMed

    Feng, Qiang; Chen, Yiran; Sun, Bo; Li, Songjie

    2014-01-01

    An optimization method for condition based maintenance (CBM) of aircraft fleet considering prognostics uncertainty is proposed. The CBM and dispatch process of aircraft fleet is analyzed first, and the alternative strategy sets for single aircraft are given. Then, the optimization problem of fleet CBM with lower maintenance cost and dispatch risk is translated to the combinatorial optimization problem of single aircraft strategy. Remain useful life (RUL) distribution of the key line replaceable Module (LRM) has been transformed into the failure probability of the aircraft and the fleet health status matrix is established. And the calculation method of the costs and risks for mission based on health status matrix and maintenance matrix is given. Further, an optimization method for fleet dispatch and CBM under acceptable risk is proposed based on an improved genetic algorithm. Finally, a fleet of 10 aircrafts is studied to verify the proposed method. The results shows that it could realize optimization and control of the aircraft fleet oriented to mission success.

  16. An Optimization Method for Condition Based Maintenance of Aircraft Fleet Considering Prognostics Uncertainty

    PubMed Central

    Chen, Yiran; Sun, Bo; Li, Songjie

    2014-01-01

    An optimization method for condition based maintenance (CBM) of aircraft fleet considering prognostics uncertainty is proposed. The CBM and dispatch process of aircraft fleet is analyzed first, and the alternative strategy sets for single aircraft are given. Then, the optimization problem of fleet CBM with lower maintenance cost and dispatch risk is translated to the combinatorial optimization problem of single aircraft strategy. Remain useful life (RUL) distribution of the key line replaceable Module (LRM) has been transformed into the failure probability of the aircraft and the fleet health status matrix is established. And the calculation method of the costs and risks for mission based on health status matrix and maintenance matrix is given. Further, an optimization method for fleet dispatch and CBM under acceptable risk is proposed based on an improved genetic algorithm. Finally, a fleet of 10 aircrafts is studied to verify the proposed method. The results shows that it could realize optimization and control of the aircraft fleet oriented to mission success. PMID:24892046

  17. Application of Strategic Planning Process with Fleet Level Analysis Methods

    NASA Technical Reports Server (NTRS)

    Mavris, Dimitri N.; Pfaender, Holger; Jimenez, Hernando; Garcia, Elena; Feron, Eric; Bernardo, Jose

    2016-01-01

    The goal of this work is to quantify and characterize the potential system-wide reduction of fuel consumption and corresponding CO2 emissions, resulting from the introduction of N+2 aircraft technologies and concepts into the fleet. Although NASA goals for this timeframe are referenced against a large twin aisle aircraft we consider their application across all vehicle classes of the commercial aircraft fleet, from regional jets to very large aircraft. In this work the authors describe and discuss the formulation and implementation of the fleet assessment by addressing the main analytical components: forecasting, operations allocation, fleet retirement, fleet replacement, and environmental performance modeling.

  18. Evolution of the deep-sea fleet that supports Canada's international trade

    DOT National Transportation Integrated Search

    2002-01-01

    This study identifies the flag-related trends of fleets used in Canada's international sea-borne trade relative to the world fleet during the 15-year period from 1985 to 1999. The goal is to determine if there is any indication that fleets that serve...

  19. A methodology to enable rapid evaluation of aviation environmental impacts and aircraft technologies

    NASA Astrophysics Data System (ADS)

    Becker, Keith Frederick

    Commercial aviation has become an integral part of modern society and enables unprecedented global connectivity by increasing rapid business, cultural, and personal connectivity. In the decades following World War II, passenger travel through commercial aviation quickly grew at a rate of roughly 8% per year globally. The FAA's most recent Terminal Area Forecast predicts growth to continue at a rate of 2.5% domestically, and the market outlooks produced by Airbus and Boeing generally predict growth to continue at a rate of 5% per year globally over the next several decades, which translates into a need for up to 30,000 new aircraft produced by 2025. With such large numbers of new aircraft potentially entering service, any negative consequences of commercial aviation must undergo examination and mitigation by governing bodies so that growth may still be achieved. Options to simultaneously grow while reducing environmental impact include evolution of the commercial fleet through changes in operations, aircraft mix, and technology adoption. Methods to rapidly evaluate fleet environmental metrics are needed to enable decision makers to quickly compare the impact of different scenarios and weigh the impact of multiple policy options. As the fleet evolves, interdependencies may emerge in the form of tradeoffs between improvements in different environmental metrics as new technologies are brought into service. In order to include the impacts of these interdependencies on fleet evolution, physics-based modeling is required at the appropriate level of fidelity. Evaluation of environmental metrics in a physics-based manner can be done at the individual aircraft level, but will then not capture aggregate fleet metrics. Contrastingly, evaluation of environmental metrics at the fleet level is already being done for aircraft in the commercial fleet, but current tools and approaches require enhancement because they currently capture technology implementation through post-processing, which does not capture physical interdependencies that may arise at the aircraft-level. The goal of the work that has been conducted here was the development of a methodology to develop surrogate fleet approaches that leverage the capability of physics-based aircraft models and the development of connectivity to fleet-level analysis tools to enable rapid evaluation of fuel burn and emissions metrics. Instead of requiring development of an individual physics-based model for each vehicle in the fleet, the surrogate fleet approaches seek to reduce the number of such models needed while still accurately capturing performance of the fleet. By reducing the number of models, both development time and execution time to generate fleet-level results may also be reduced. The initial steps leading to surrogate fleet formulation were a characterization of the commercial fleet into groups based on capability followed by the selection of a reference vehicle model and a reference set of operations for each group. Next, three potential surrogate fleet approaches were formulated. These approaches include the parametric correction factor approach, in which the results of a reference vehicle model are corrected to match the aggregate results of each group; the average replacement approach, in which a new vehicle model is developed to generate aggregate results of each group, and the best-in-class replacement approach, in which results for a reference vehicle are simply substituted for the entire group. Once candidate surrogate fleet approaches were developed, they were each applied to and evaluated over the set of reference operations. Then each approach was evaluated for their ability to model variations in operations. Finally, the ability of each surrogate fleet approach to capture implementation of different technology suites along with corresponding interdependencies between fuel burn and emissions was evaluated using the concept of a virtual fleet to simulate the technology response of multiple aircraft families. The results of experimentation led to a down selection to the best approach to use to rapidly characterize the performance of the commercial fleet for accurately in the context of acceptability of current fleet evaluation methods. The parametric correction factor and average replacement approaches were shown to be successful in capturing reference fleet results as well as fleet performance with variations in operations. The best-in-class replacement approach was shown to be unacceptable as a model for the larger fleet in each of the scenarios tested. Finally, the average replacement approach was the only one that was successful in capturing the impact of technologies on a larger fleet. These results are meaningful because they show that it is possible to calculate the fuel burn and emissions of a larger fleet with a reduced number of physics-based models within acceptable bounds of accuracy. At the same time, the physics-based modeling also provides the ability to evaluate the impact of technologies on fleet-level fuel burn and emissions metrics. The value of such a capability is that multiple future fleet scenarios involving changes in both aircraft operations and technology levels may now be rapidly evaluated to inform and equip policy makers of the implications of impacts of changes on fleet-level metrics.

  20. A Framework for Creating Value from Fleet Data at Ecosystem Level

    NASA Astrophysics Data System (ADS)

    Kinnunen, Sini-Kaisu; Hanski, Jyri; Marttonen-Arola, Salla; Kärri, Timo

    2017-09-01

    As companies have recently gotten more interested in utilizing the increasingly gathered data and realizing the potential of data analysis, the ability to upgrade data into value for business has been recognized as an advantage. Companies gain competitive advantage if they are able to benefit from the fleet data that is produced both in and outside the boundaries of the company. Benefits of fleet management are based on the possibility to have access to the massive amounts of asset data that can then be utilized e.g. to gain cost savings and to develop products and services. The ambition of the companies is to create value from fleet data but this requires that different actors in ecosystem are working together for a common goal - to get the most value out of fleet data for the ecosystem. In order that this could be possible, we need a framework to meet the requirements of the fleet life-cycle data utilization. This means that the different actors in the ecosystem need to understand their role in the fleet data refining process in order to promote the value creation from fleet data. The objective of this paper is to develop a framework for knowledge management in order to create value from fleet data in ecosystems. As a result, we present a conceptual framework which helps companies to develop their asset management practices related to the fleet of assets.

  1. 33 CFR 162.270 - Restricted areas in vicinity of Maritime Administration Reserve Fleets.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Maritime Administration Reserve Fleets. 162.270 Section 162.270 Navigation and Navigable Waters COAST GUARD... REGULATIONS § 162.270 Restricted areas in vicinity of Maritime Administration Reserve Fleets. (a) The... National Defense Reserve Fleets of the Maritime Administration, Department of Transportation: (1) James...

  2. Alternative Fuels Data Center: Fleet Application for Public Transit

    Science.gov Websites

    Vehicles Public Transit Vehicles to someone by E-mail Share Alternative Fuels Data Center : Fleet Application for Public Transit Vehicles on Facebook Tweet about Alternative Fuels Data Center : Fleet Application for Public Transit Vehicles on Twitter Bookmark Alternative Fuels Data Center: Fleet

  3. Alternative Fuels Data Center: Fleet Applications for Vehicles

    Science.gov Websites

    Applications for Vehicles to someone by E-mail Share Alternative Fuels Data Center: Fleet Applications for Vehicles on Facebook Tweet about Alternative Fuels Data Center: Fleet Applications for Vehicles on Twitter Bookmark Alternative Fuels Data Center: Fleet Applications for Vehicles on Google

  4. 41 CFR 101-39.208 - Vehicles removed from defined areas.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.2-GSA Interagency Fleet Management System Services... operated outside the geographical area served by the issuing GSA IFMS fleet management center. However... shall notify the issuing GSA IFMS fleet management center of the following: (1) The location at which...

  5. 50 CFR 660.338 - Limited entry permits-small fleet.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Limited entry permits-small fleet. 660.338 Section 660.338 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND... Groundfish Fisheries § 660.338 Limited entry permits-small fleet. (a) Small limited entry fisheries fleets...

  6. 41 CFR 101-39.107 - Limited exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.1-Establishment, Modification, and Discontinuance of Interagency Fleet... incorporated in the fleet management system, if the exemption has been mutually agreed upon by the... of the fleet management system. [51 FR 11023, Apr. 1, 1986, as amended at 56 FR 59888, Nov. 26, 1991] ...

  7. 41 CFR 101-39.204 - Obtaining motor vehicles for indefinite assignment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., TRANSPORTATION, AND MOTOR VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.2-GSA Interagency Fleet Management... related services of the GSA Interagency Fleet Management System (IFMS) are provided to requesting agencies... have been consolidated into the supporting GSA IFMS fleet management center, and no agency-owned...

  8. 48 CFR 970.5223-5 - DOE motor vehicle fleet fuel efficiency.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... and Contract Clauses for Management and Operating Contracts 970.5223-5 DOE motor vehicle fleet fuel..., insert the following clause in contracts providing for Contractor management of the motor vehicle fleet... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false DOE motor vehicle fleet...

  9. The Advanced Surface Force Fleet: A Proposal for an Alternate Surface Force Structure and Its Impact in the Asian Pacific Theater

    DTIC Science & Technology

    2015-12-01

    B. THE PROSPECTIVE 2040 7TH FLEET FORCES Based on the current and planned naval forces allocated to 7th Fleet, it is assumed that the Navy’s 2040...approximately 15 percent of The Advanced Surface Force Fleet, or 20 ships, are allocated to 7th Fleet. Furthermore, 12 of The Advanced Surface...production, personnel support for cleanup and recovery efforts, berthing capability, and medical support.90 After determining the critical missions

  10. Electric and Hybrid Vehicles Program. Sixteenth annual report to Congress for fiscal year 1992

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1993-08-01

    This report describes the progress achieved in developing electric and hybrid vehicle technologies, beginning with highlights of recent accomplishments in FY 1992. Detailed descriptions are provided of program activities during FY 1992 in the areas of battery, fuel cell, and propulsion system development, and testing and evaluation of new technology in fleet site operations and in laboratories. This Annual Report also contains a status report on incentives and use of foreign components, as well as a list of publications resulting from the DOE program.

  11. DORCA computer program. Volume 1: User's guide

    NASA Technical Reports Server (NTRS)

    Wray, S. T., Jr.

    1971-01-01

    The Dynamic Operational Requirements and Cost Analysis Program (DORCA) was written to provide a top level analysis tool for NASA. DORCA relies on a man-machine interaction to optimize results based on external criteria. DORCA relies heavily on outside sources to provide cost information and vehicle performance parameters as the program does not determine these quantities but rather uses them. Given data describing missions, vehicles, payloads, containers, space facilities, schedules, cost values and costing procedures, the program computes flight schedules, cargo manifests, vehicle fleet requirements, acquisition schedules and cost summaries. The program is designed to consider the Earth Orbit, Lunar, Interplanetary and Automated Satellite Programs. A general outline of the capabilities of the program are provided.

  12. Alternative Fuels Data Center: Seattle Rideshare Fleet Adds EVs, Enjoys

    Science.gov Websites

    Fuels Data Center: Seattle Rideshare Fleet Adds EVs, Enjoys Success on Facebook Tweet about Alternative Fuels Data Center: Seattle Rideshare Fleet Adds EVs, Enjoys Success on Twitter Bookmark Alternative Fuels Data Center: Seattle Rideshare Fleet Adds EVs, Enjoys Success on Google Bookmark Alternative Fuels

  13. 41 CFR 101-39.105-1 - Transfers from discontinued or curtailed fleet management systems.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... discontinued or curtailed fleet management systems. 101-39.105-1 Section 101-39.105-1 Public Contracts and... AVIATION, TRANSPORTATION, AND MOTOR VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.1-Establishment, Modification, and Discontinuance of Interagency Fleet Management Systems § 101-39.105-1 Transfers from...

  14. Alternative Fuels Data Center: New Mexico Utility Sparks Change with Fleet

    Science.gov Websites

    Electrification New Mexico Utility Sparks Change with Fleet Electrification to someone by E -mail Share Alternative Fuels Data Center: New Mexico Utility Sparks Change with Fleet Electrification on Facebook Tweet about Alternative Fuels Data Center: New Mexico Utility Sparks Change with Fleet

  15. 75 FR 8563 - Safety Zone; Fleet Week Maritime Festival, Pier 66, Elliott Bay, Seattle, WA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-25

    ...-AA00 Safety Zone; Fleet Week Maritime Festival, Pier 66, Elliott Bay, Seattle, WA AGENCY: Coast Guard... Fleet Week Maritime Festival. Entry into, transit through, mooring, or anchoring within these zones is... Fleet Week Maritime Festival. This safety zone is necessary as these events have historically resulted...

  16. 75 FR 71638 - Safety Zone; Fleet Week Maritime Festival, Pier 66, Elliot Bay, Seattle, WA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-24

    ...-AA00 Safety Zone; Fleet Week Maritime Festival, Pier 66, Elliot Bay, Seattle, WA AGENCY: Coast Guard...) entitled ``Safety Zone; Fleet Week Maritime Festival, Pier 66, Elliot Bay, Seattle, WA'' (Docket number...; Fleet Week Maritime Festival, Pier 66, Elliott Bay, Seattle, Washington. (a) Location. The following...

  17. Modelling the spatial behaviour of a tropical tuna purse seine fleet.

    PubMed

    Davies, Tim K; Mees, Chris C; Milner-Gulland, E J

    2014-01-01

    Industrial tuna fisheries operate in the Indian, Atlantic and Pacific Oceans, but concerns over sustainability and environmental impacts of these fisheries have resulted in increased scrutiny of how they are managed. An important but often overlooked factor in the success or failure of tuna fisheries management is the behaviour of fishers and fishing fleets. Uncertainty in how a fishing fleet will respond to management or other influences can be reduced by anticipating fleet behaviour, although to date there has been little research directed at understanding and anticipating the human dimension of tuna fisheries. The aim of this study was to address gaps in knowledge of the behaviour of tuna fleets, using the Indian Ocean tropical tuna purse seine fishery as a case study. We use statistical modelling to examine the factors that influence the spatial behaviour of the purse seine fleet at broad spatiotemporal scales. This analysis reveals very high consistency between years in the use of seasonal fishing grounds by the fleet, as well as a forcing influence of biophysical ocean conditions on the distribution of fishing effort. These findings suggest strong inertia in the spatial behaviour of the fleet, which has important implications for predicting the response of the fleet to natural events or management measures (e.g., spatial closures).

  18. 75 FR 3183 - Approval and Promulgation of Air Quality Implementation Plan: Kentucky; Approval Section 110(a)(1...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-20

    ...) Federal motor vehicle control program; (2) fleet turnover of automobiles; (3) low reid vapor pressure of... vehicles standard; (6) large nonroad diesel engines rule; (7) nonroad spark ignition engines and recreational engines standard; (8) point source emission reductions; (9) Air Products and Chemicals -21-157...

  19. DEVELOPMENT OF CRITERIA AND METHODS FOR EVALUATING TRAINER AIRCRAFT EFFECTIVENESS.

    ERIC Educational Resources Information Center

    KUSEWITT, J.B.

    THE PURPOSE OF THIS STUDY WAS TO DEVELOP A METHOD FOR DETERMINING OBJECTIVE MEASURES OF TRAINER AIRCRAFT EFFECTIVENESS TO EVALUATE PROGRAM ALTERNATIVES FOR TRAINING PILOTS FOR FLEET FIGHTER AND ATTACK-TYPE AIRCRAFT. THE TRAINING SYLLABUS WAS BASED ON AVERAGE STUDENT ABILITY. THE BASIC PROBLEM WAS TO ESTABLISH QUANTITATIVE TIME-DIFFICULTY…

  20. 10 CFR 490.705 - Use of credits.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Biodiesel Fuel Use Credit § 490... the Energy Policy Act of 1992. (c) A fleet or covered person that is a biodiesel alternative fuel... person may not trade or bank biodiesel fuel credits. [64 FR 27174, May 19, 1999, as amended at 66 FR 2210...

  1. 10 CFR 490.705 - Use of credits.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Biodiesel Fuel Use Credit § 490... the Energy Policy Act of 1992. (c) A fleet or covered person that is a biodiesel alternative fuel... person may not trade or bank biodiesel fuel credits. [64 FR 27174, May 19, 1999, as amended at 66 FR 2210...

  2. 10 CFR 490.705 - Use of credits.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Biodiesel Fuel Use Credit § 490... the Energy Policy Act of 1992. (c) A fleet or covered person that is a biodiesel alternative fuel... person may not trade or bank biodiesel fuel credits. [64 FR 27174, May 19, 1999, as amended at 66 FR 2210...

  3. 10 CFR 490.705 - Use of credits.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Biodiesel Fuel Use Credit § 490... the Energy Policy Act of 1992. (c) A fleet or covered person that is a biodiesel alternative fuel... person may not trade or bank biodiesel fuel credits. [64 FR 27174, May 19, 1999, as amended at 66 FR 2210...

  4. 10 CFR 490.705 - Use of credits.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Biodiesel Fuel Use Credit § 490... the Energy Policy Act of 1992. (c) A fleet or covered person that is a biodiesel alternative fuel... person may not trade or bank biodiesel fuel credits. [64 FR 27174, May 19, 1999, as amended at 66 FR 2210...

  5. 76 FR 31881 - Fisheries of the Exclusive Economic Zone Off Alaska; Groundfish Retention Standard; Emergency...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-02

    ... from the groundfish retention standard (GRS) program in the Bering Sea and Aleutian Islands management... that considered by the North Pacific Fishery Management Council or that implemented by NMFS. As a... level of retention and to generate an unanticipated level of noncompliance in the Amendment 80 fleet...

  6. 77 FR 44572 - Second Fishing Capacity Reduction Program for the Longline Catcher Processor Subsector of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-30

    ... the economic viability of members of the fleet and increased the economic and social burden on fishery... the number of harvesters in the fishery, increase the economic efficiency of harvesting, and... of the Regulatory Flexibility Act (RFA), to describe the economic impacts that this proposed rule, if...

  7. 40 CFR 86.1866-12 - CO2 fleet average credit programs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... technologies designed to reduce air conditioning refrigerant leakage over the useful life of their passenger... implementing specific air conditioning system technologies designed to reduce air conditioning-related CO2... than 10% when compared to previous industry standard designs): 1.1 g/mi. (viii) Oil separator: 0.6 g/mi...

  8. 40 CFR 86.1866-12 - CO2 fleet average credit programs.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... technologies designed to reduce air conditioning refrigerant leakage over the useful life of their passenger... implementing specific air conditioning system technologies designed to reduce air conditioning-related CO2... than 10% when compared to previous industry standard designs): 1.1 g/mi. (viii) Oil separator: 0.6 g/mi...

  9. 46 CFR 295.12 - Priority for awarding agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... to all vessels within a priority set forth herein, MARAD shall award to each eligible applicant in... 46 Shipping 8 2010-10-01 2010-10-01 false Priority for awarding agreements. 295.12 Section 295.12... OPERATORS MARITIME SECURITY PROGRAM (MSP) Establishment of MSP Fleet and Eligibility § 295.12 Priority for...

  10. Reliability-Growth Assessment, Prediction, and Control for Electronic Engine Control (GAPCEEC)

    DTIC Science & Technology

    1984-04-01

    COMPEtTIN FOR Control (GAPCEEC) 4. PERFORMING ORG. REPORT NUMUR ______________________________ P&W/GPD/FR-17847 7. AUTI4OR(e) Michael E. McGlone...Control for Electronic Engine Control (GAPCEEC) program was performed under contract F33615-81 -C-2015. This 22-month program I. was formulated to study and...and (3) that data should be tracked c-ontinuously on an indiidual and fleet basis. UNCLASSIFIED 86CURITY CLASSIICATION OF THIS PAGErWmm Doe Rateio

  11. Air transportation noise technology overview

    NASA Technical Reports Server (NTRS)

    Maggin, B.; Chestnutt, D.

    1973-01-01

    The NASA and DOT technology program planning for quieter air transportation systems is reviewed. To put this planning in context, the nature of the noise problem and the projected nature of the air transportation fleet are identified. The technology program planning reviewed here is discussed in relation to the following areas of activity: systems analysis, community acceptance, basic research and technology, and the various classes of civil aircraft, i.e. existing and advanced transports, powered-lift transports, and general aviation.

  12. Alternative Fuels Data Center: Golden Eagle Distributors Inc. to Convert

    Science.gov Websites

    several years. Golden Eagle will convert all fleet vehicles to CNG in their six branch operations Entire Fleet to CNG Golden Eagle Distributors Inc. to Convert Entire Fleet to CNG to someone by E-mail Share Alternative Fuels Data Center: Golden Eagle Distributors Inc. to Convert Entire Fleet

  13. 41 CFR 102-34.340 - Do we need a fleet management information system?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... management information system? 102-34.340 Section 102-34.340 Public Contracts and Property Management Federal... VEHICLE MANAGEMENT Federal Fleet Report § 102-34.340 Do we need a fleet management information system? Yes, you must have a fleet management information system at the department or agency level that — (a...

  14. Alternative Fuels Data Center: New Hampshire Fleet Revs up With Natural Gas

    Science.gov Websites

    New Hampshire Fleet Revs up With Natural Gas to someone by E-mail Share Alternative Fuels Data Center: New Hampshire Fleet Revs up With Natural Gas on Facebook Tweet about Alternative Fuels Data Center: New Hampshire Fleet Revs up With Natural Gas on Twitter Bookmark Alternative Fuels Data Center

  15. Alternative Fuels Data Center: District of Columbia's Government Fleet Uses

    Science.gov Websites

    a Wide Variety of Alternative FuelsA> District of Columbia's Government Fleet Uses a Wide Variety Government Fleet Uses a Wide Variety of Alternative Fuels on Facebook Tweet about Alternative Fuels Data Center: District of Columbia's Government Fleet Uses a Wide Variety of Alternative Fuels on Twitter

  16. 75 FR 20778 - Security Zone; Portland Rose Festival Fleet Week, Willamette River, Portland, OR

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-21

    ...-AA87 Security Zone; Portland Rose Festival Fleet Week, Willamette River, Portland, OR AGENCY: Coast... during the Portland Rose Festival Fleet Week from June 2, 2010, through June 7, 2010. The security zone... is a need to provide a security zone for the 2010 Portland Rose Festival Fleet Week, and there is...

  17. 76 FR 30014 - Safety Zone; Fleet Week Maritime Festival, Pier 66, Elliott Bay, Seattle, WA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-24

    ...-AA00 Safety Zone; Fleet Week Maritime Festival, Pier 66, Elliott Bay, Seattle, WA AGENCY: Coast Guard...) entitled ``Safety Zone; Fleet Week Maritime Festival, Pier 66, Elliott Bay, Seattle, WA'' in the Federal... is added to read as follows: Sec. 165.1330 Safety Zone; Fleet Week Maritime Festival, Pier 66...

  18. 41 CFR 102-34.340 - Do we need a fleet management information system?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... management information system? 102-34.340 Section 102-34.340 Public Contracts and Property Management Federal... VEHICLE MANAGEMENT Federal Fleet Report § 102-34.340 Do we need a fleet management information system? Yes, you must have a fleet management information system at the department or agency level that — (a...

  19. 41 CFR 102-34.340 - Do we need a fleet management information system?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... management information system? 102-34.340 Section 102-34.340 Public Contracts and Property Management Federal... VEHICLE MANAGEMENT Federal Fleet Report § 102-34.340 Do we need a fleet management information system? Yes, you must have a fleet management information system at the department or agency level that — (a...

  20. 41 CFR 102-34.340 - Do we need a fleet management information system?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... management information system? 102-34.340 Section 102-34.340 Public Contracts and Property Management Federal... VEHICLE MANAGEMENT Federal Fleet Report § 102-34.340 Do we need a fleet management information system? Yes, you must have a fleet management information system at the department or agency level that — (a...

  1. 41 CFR 102-34.340 - Do we need a fleet management information system?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... management information system? 102-34.340 Section 102-34.340 Public Contracts and Property Management Federal... VEHICLE MANAGEMENT Federal Fleet Report § 102-34.340 Do we need a fleet management information system? Yes, you must have a fleet management information system at the department or agency level that — (a...

  2. 77 FR 75257 - Proposed Collection of Information: Medium- and Heavy-Duty Truck Fleet Survey

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-19

    ...-0170] Proposed Collection of Information: Medium- and Heavy-Duty Truck Fleet Survey AGENCY: National... collection of information will be in the form of a one-time survey of medium- and heavy-duty truck fleet... collection. OMB Control Number: To be issued at time of approval. Title: Medium- and Heavy-Duty Truck Fleet...

  3. Assessment and Correlation of Customer and Rater Response to Cold-Start and Warmup Driveability

    DTIC Science & Technology

    1993-08-01

    Customer satisfaction fleet Year N % 1986 13 18 1988 10 14 1987 12 18 1988 12 16 1989 14 19 1990 9 12 1991 3 4 Consumer I Rater Fleet Hydrocarbon fuel...2 4 1991 0 0 Fuel system * Customer satisfaction fleet Fuel system N % Carbureted 19 26 PFI 33 48 1T1 21 29 Consumer I Rater Fleet Hydrooarbon fuel...between the customer fleet and one of the consumer /rater subfleets; these vehicles are included in both places in the tables above. 30 TABLE 2 AVERAGE

  4. COMPARATIVE STUDY ON EXHAUST EMISSIONS FROM DIESEL- AND CNG-POWERED URBAN BUSES

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    COROLLER, P; PLASSAT, G

    2003-08-24

    Couple years ago, ADEME engaged programs dedicated to the urban buses exhaust emissions studies. The measures associated with the reduction of atmospheric and noise pollution has particular importance in the sector of urban buses. In many cases, they illustrate the city's environmental image and contribute to reinforcing the attractiveness of public transport. France's fleet in service, presently put at about 14,000 units, consumes about 2 per cent of the total energy of city transport. It causes about 2 per cent of the HC emissions and from 4 to 6 per cent of the NOx emissions and particles. These vehicles typicallymore » have a long life span (about 15 years) and are relatively expensive to buy, about 150.000 euros per unit. Several technical solutions were evaluated to quantify, on a real condition cycle for buses, on one hand pollutants emissions, fuel consumption and on the other hand reliability, cost in real existing fleet. This paper presents main preliminary results on urban buses exhaust emission on two different cases: - existing Diesel buses, with fuel modifications (Diesel with low sulphur content), Diesel with water emulsion and bio-Diesel (30% oil ester in standard Diesel fuel); renovating CNG powered Euro II buses fleet, over representative driving cycles, set up by ADEME and partners. On these cycles, pollutants (regulated and unregulated) were measured as well as fuel consumption, at the beginning of a program and one year after to quantify reliability and increase/decrease of pollutants emissions. At the same time, some after-treatment technologies were tested under real conditions and several vehicles. Information such as fuel consumption, lubricant analysis, problem on the technology were following during a one year program. On the overall level, it is the combination of various action, pollution-reduction and renewal that will make it possible to meet the technological challenge of reducing emissions and fuel consumption by urban bus networks.« less

  5. Investigation of Dynamic and Physical Processes in the Upper Troposphere and Lower Stratosphere

    NASA Technical Reports Server (NTRS)

    Selkirk, Henry B.; Pfister, Leonhard (Technical Monitor)

    2002-01-01

    Research under this Cooperative Agreement has been funded by several NASA Earth Science programs: the Atmospheric Effects of Radiation Program (AEAP), the Upper Atmospheric Research Program (UARP), and most recently the Atmospheric Chemistry and Modeling Assessment Program (ACMAP). The purpose of the AEAP was to understand the impact of the present and future fleets of conventional jet traffic on the upper troposphere and lower stratosphere, while complementary airborne observations under UARP seek to understand the complex interactions of dynamical and chemical processes that affect the ozone layer. The ACMAP is a more general program of modeling and data analysis in the general area of atmospheric chemistry and dynamics, and the Radiation Sciences program.

  6. Developing a Fleet Standardization Index for Airline Planning

    NASA Technical Reports Server (NTRS)

    deBorgesPan, Alexis George; EspiritoSanto, Respicio A., Jr.

    2003-01-01

    Quantifying subjective aspects is a difficult task that requires a great dedication of time from researchers and analysts. Nevertheless, one of the main objectives of it is to pave the way for a better understanding of the focused aspects. Fleet standardization is one of these subjective aspects that is extremely difficult to mm into numbers. Although, it is of great importance to know the benefits that may come with a higher level of standardization for airlines, which may be economical advantages, maintenance facilitation and others. A more standardized fleet may represent lower costs of operations and maintenance facilitation and others. A more standardized fleet may represent lower costs of operations and maintenance plus a much better planning of routes and flights. This study presents the first step on developing an index, hereto called "Fleet Standardization Index" or FSI (or IPF in Portuguese, for "Indice de Padronizacao de Frotas"), that will allow senior airline planners to compare different fleets and also simulate some results from maintaining or renewing their fleets. Although being a preliminary study, the results obtained may already be tested to compare different fleets (different airlines) and also analyze some possible impacts of a fleet renewal before it takes place. Therefore, the main objective of this paper is to introduce the proposed IPF index and to demonstrate that it is inversely proportional to the number of different airplane models, engines and other equipment, such as avionics.

  7. Long-Term Fuel-Specific NO x and Particle Emission Trends for In-Use Heavy-Duty Vehicles in California.

    PubMed

    Haugen, Molly J; Bishop, Gary A

    2018-05-15

    Two California heavy-duty fleets have been measured in 2013, 2015, and 2017 using the On-Road Heavy-Duty Measurement System. The Port of Los Angeles drayage fleet has increased in age by 3.3 model years (4.2-7.5 years old) since 2013, with little fleet turnover. Large increases in fuel-specific particle emissions (PM) observed in 2015 were reversed in 2017, returning to near 2013 levels, suggesting repairs and or removal of high emitting vehicles. Fuel-specific oxides of nitrogen (NO x ) emissions of this fleet have increased, and NO x after-treatment systems do not appear to perform ideally in this setting. At the Cottonwood weigh station in northern California, the fleet age has declined (7.8 to 6 years old) since 2013 due to fleet turnover, significantly lowering the average fuel-specific emissions for PM (-87%), black carbon (-76%), and particle number (-64%). Installations of retrofit-diesel particulate filters in model year 2007 and older vehicles have further decreased particle emissions. Cottonwood fleet fuel-specific NO x emissions have decreased slightly (-8%) during this period; however, newer technology vehicles with selective catalytic reduction systems (SCR) promise an additional factor of 4-5 further reductions in the long-haul fleet emissions as California transitions to an all SCR-equipped fleet.

  8. Light Water Reactor Sustainability Program: Digital Technology Business Case Methodology Guide

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Thomas, Ken; Lawrie, Sean; Hart, Adam

    The Department of Energy’s (DOE’s) Light Water Reactor Sustainability Program aims to develop and deploy technologies that will make the existing U.S. nuclear fleet more efficient and competitive. The program has developed a standard methodology for determining the impact of new technologies in order to assist nuclear power plant (NPP) operators in building sound business cases. The Advanced Instrumentation, Information, and Control (II&C) Systems Technologies Pathway is part of the DOE’s Light Water Reactor Sustainability (LWRS) Program. It conducts targeted research and development (R&D) to address aging and reliability concerns with the legacy instrumentation and control and related information systemsmore » of the U.S. operating light water reactor (LWR) fleet. This work involves two major goals: (1) to ensure that legacy analog II&C systems are not life-limiting issues for the LWR fleet and (2) to implement digital II&C technology in a manner that enables broad innovation and business improvement in the NPP operating model. Resolving long-term operational concerns with the II&C systems contributes to the long-term sustainability of the LWR fleet, which is vital to the nation’s energy and environmental security. The II&C Pathway is conducting a series of pilot projects that enable the development and deployment of new II&C technologies in existing nuclear plants. Through the LWRS program, individual utilities and plants are able to participate in these projects or otherwise leverage the results of projects conducted at demonstration plants. Performance advantages of the new pilot project technologies are widely acknowledged, but it has proven difficult for utilities to derive business cases for justifying investment in these new capabilities. Lack of a business case is often cited by utilities as a barrier to pursuing wide-scale application of digital technologies to nuclear plant work activities. The decision to move forward with funding usually hinges on demonstrating actual cost reductions that can be credited to budgets and thereby truly reduce O&M or capital costs. Technology enhancements, while enhancing work methods and making work more efficient, often fail to eliminate workload such that it changes overall staffing and material cost requirements. It is critical to demonstrate cost reductions or impacts on non-cost performance objectives in order for the business case to justify investment by nuclear operators. The Business Case Methodology (BCM) addresses the “benefit” side of the analysis—as opposed to the cost side—and how the organization evaluates discretionary projects (net present value (NPV), accounting effects of taxes, discount rates, etc.). The cost and analysis side is not particularly difficult for the organization and can usually be determined with a fair amount of precision (not withstanding implementation project cost overruns). It is in determining the "benefits" side of the analysis that utilities have more difficulty in technology projects and that is the focus of this methodology.« less

  9. Alternative Fuels Data Center: Kansas City Greens Its Fleet With Natural

    Science.gov Websites

    Gas and Biodiesel Kansas City Greens Its Fleet With Natural Gas and Biodiesel to someone by E -mail Share Alternative Fuels Data Center: Kansas City Greens Its Fleet With Natural Gas and Biodiesel and Biodiesel on Twitter Bookmark Alternative Fuels Data Center: Kansas City Greens Its Fleet With

  10. Pages - U.S. Fleet Cyber Command

    Science.gov Websites

    Links Expand Links : U.S. Fleet Cyber Command Help (new window) Site Help Page Content Website 2nd Banner.jpg Since its establishment on Jan. 29, 2010, U.S. Fleet Cyber Command (FCC)/U.S. TENTH Fleet (C10F civilians organized into 26 active commands, 40 Cyber Mission Force units, and 27 reserve commands around

  11. DOE Office of Scientific and Technical Information (OSTI.GOV)

    The U.S. Department of Energy (DOE) and U.S. General Services Administration (GSA) are issuing comprehensive guidance on the federal fleet requirements of Executive Order (E.O.) 13693, Planning for Federal Sustainability in the Next Decade (E.O. 13693), to help federal agencies subject to the executive order develop an overall approach for reducing total fleet greenhouse gas (GHG) emissions and fleet-wide per-mile GHG emissions, and ensure the approach helps these agencies meet their requirements. Three key GHG emissions reduction strategies - right-sizing fleets to mission, increasing fleet fuel efficiency, and displacing petroleum with alternative fuel use - are essential to meeting themore » requirements and are discussed further in this document. This guidance document is intended to help agency Chief Sustainability Officers (CSOs) and headquarters fleet managers craft tailored executable plans that achieve the purpose of E.O. 13693. The guidance will assist agencies in completing the first phase of a comprehensive fleet management framework by identifying the strategies each agency will then implement to meet or exceed its requirements.« less

  12. Proton exchange membrane fuel cell system diagnosis based on the signed directed graph method

    NASA Astrophysics Data System (ADS)

    Hua, Jianfeng; Lu, Languang; Ouyang, Minggao; Li, Jianqiu; Xu, Liangfei

    The fuel-cell powered bus is becoming the favored choice for electric vehicles because of its extended driving range, zero emissions, and high energy conversion efficiency when compared with battery-operated electric vehicles. In China, a demonstration program for the fuel cell bus fleet operated at the Beijing Olympics in 2008 and the Shanghai Expo in 2010. It is necessary to develop comprehensive proton exchange membrane fuel cell (PEMFC) diagnostic tools to increase the reliability of these systems. It is especially critical for fuel-cell city buses serving large numbers of passengers using public transportation. This paper presents a diagnostic analysis and implementation study based on the signed directed graph (SDG) method for the fuel-cell system. This diagnostic system was successfully implemented in the fuel-cell bus fleet at the Shanghai Expo in 2010.

  13. Improving Transportation Services for the University of the Thai Chamber of Commerce: A Case Study on Solving the Mixed-Fleet Vehicle Routing Problem with Split Deliveries

    NASA Astrophysics Data System (ADS)

    Suthikarnnarunai, N.; Olinick, E.

    2009-01-01

    We present a case study on the application of techniques for solving the Vehicle Routing Problem (VRP) to improve the transportation service provided by the University of The Thai Chamber of Commerce to its staff. The problem is modeled as VRP with time windows, split deliveries, and a mixed fleet. An exact algorithm and a heuristic solution procedure are developed to solve the problem and implemented in the AMPL modeling language and CPLEX Integer Programming solver. Empirical results indicate that the heuristic can find relatively good solutions in a small fraction of the time required by the exact method. We also perform sensitivity analysis and find that a savings in outsourcing cost can be achieved with a small increase in vehicle capacity.

  14. Controlled Speed Accessory Drive demonstration program

    NASA Technical Reports Server (NTRS)

    Hoehn, F. W.

    1981-01-01

    A Controlled Speed Accessory Drive System was examined in an effort to improve the fuel economy of passenger cars. Concept feasibility and the performance of a typical system during actual road driving conditions were demonstrated. The CSAD system is described as a mechanical device which limits engine accessory speeds, thereby reducing parasitic horsepower losses and improving overall vehicle fuel economy. Fuel consumption data were compiled for fleets of GSA vehicles. Various motor pool locations were selected, each representing different climatic conditions. On the basis of a total accumulated fleet usage of nearly three million miles, an overall fuel economy improvement of 6 percent to 7 percent was demonstrated. Coincident chassis dynamometer tests were accomplished on selected vehicles to establish the effect of different accessory drive systems on exhaust emissions, and to evaluate the magnitude of the mileage benefits which could be derived.

  15. Light Water Reactor Sustainability Program Advanced Instrumentation, Information, and Control Systems Technologies Technical Program Plan for FY 2016

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hallbert, Bruce Perry; Thomas, Kenneth David

    2015-10-01

    Reliable instrumentation, information, and control (II&C) systems technologies are essential to ensuring safe and efficient operation of the U.S. light water reactor (LWR) fleet. These technologies affect every aspect of nuclear power plant (NPP) and balance-of-plant operations. In 1997, the National Research Council conducted a study concerning the challenges involved in modernization of digital instrumentation and control systems in NPPs. Their findings identified the need for new II&C technology integration.

  16. NASA Space Shuttle Program: Shuttle Environmental Assurance (SEA) Initiative

    NASA Technical Reports Server (NTRS)

    Glover, Steve E.; McCool, Alex (Technical Monitor)

    2002-01-01

    The first Space Shuttle flight was in 1981 and the fleet was originally expected to be replaced with a new generation vehicle in the early 21st century. Space Shuttle Program (SSP) elements proactively address environmental and obsolescence concerns and continue to improve safety and supportability. The SSP manager created the Shuttle Environmental Assurance (SEA) Initiative in 2000. SEA is to provide an integrated approach for the SSP to promote environmental excellence, proactively manage materials obsolescence, and optimize associated resources.

  17. Tailoring Shipboard Training to Fleet Performance Needs: III. Development of Deckplate Procedural Training for the Shipboard Propulsion Plant Operator Training (SPPOT) Program.

    DTIC Science & Technology

    1981-10-01

    McMichael 7/i Released by James F. Kelly, Jr. Commanding Officer Navy Personnel Research and Development Center San Diego, California 92152 UNCLASSIFTED...Shipboard training media, Training Aids. 20., AGSTRACT (Cfnust on resee ofE. It neep se n ~11 by Wleek Mabee .) In designing a shipboard training program...Engineering Department personnel of CONSTELLATION. Without their help, the design and the development of SPPOT would not have been possible. JAMES F. KELLY

  18. Fleet/TYCOM Level Survey of Armament Handling Problems - Task One of the Naval Aviation Armament Support Equipment Program Management Study

    DTIC Science & Technology

    1977-06-21

    7. AUTHOR(#) 6. CONTRACT OR GRANT NUMBER(#) PILA /UDERIAN 9. PERFORMING ORGANIZATION NAME AND ADDRESS 10. PROGRAM ELEMENT. PROJECT, TASK...mechanically complex (i.e. contains an internal combustion engine) and/or comes in direct support of the aircraft is managed and maintained by the AIMD. The...an internal combustion engine. Accordingly, only the Aero 33D/E Trailer, Aero 51B Trailer, 21A/C Bomb Skid, and Aero 47A Weapons Loader are maintained

  19. Harrier Information Management System (HIMS): The system and the approach

    NASA Astrophysics Data System (ADS)

    Reynolds, D. J.

    1990-01-01

    The Harrier GR5 is to be fleet-fitted with an engine monitoring system. The ground station known as HIMS was developed to enable engineers to analyze parameter exceedance and component life count data collected from it. The HIMS and its development program are reviewed. Counts can vary from aircraft to aircraft for a given number of flying hours and lifting on this basis is expected to yield considerable savings. Aspects relevant to future aircraft health monitoring programs are considered.

  20. Imaging spectrometer concepts for next-generation planetary missions

    NASA Technical Reports Server (NTRS)

    Herring, M.; Juergens, D. W.; Kupferman, P. N.; Vane, G.

    1984-01-01

    In recent years there has been an increasing interest in the imaging spectrometer concept, in which imaging is accomplished in multiple, contiguous spectral bands at typical intervals of 5 to 20 nm. There are two implementations of this concept under consideration for upcoming planetary missions. One is the scanning, or 'whisk-broom' approach, in which each picture element (pixel) of the scene is spectrally dispersed onto a linear array of detectors; the spatial information is provided by a scan mirror in combination with the vehicle motion. The second approach is the 'push-broom' imager, in which a line of pixels from the scene is spectrally dispersed onto a two-dimensional (area-array) detector. In this approach, the scan mirror is eliminated, but the optics and focal plane are more complex. This paper discusses the application of these emerging instrument concepts to the planetary program. Key issues are the trade-off between the two types of imaging spectrometer, the available data rate from a typical planetary mission, and the focal-plane cooling requirements. Specific straw-man conceptual designs for the Mars Geoscience/Climatology Orbiter (MGCO) and the Mariner Mark II Comet Rendezvous/Asteroid Flyby (CRAF) missions are discussed.

  1. 40 CFR 86.1710-99 - Fleet average non-methane organic gas exhaust emission standards for light-duty vehicles and...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 20 2012-07-01 2012-07-01 false Fleet average non-methane organic gas....1710-99 Fleet average non-methane organic gas exhaust emission standards for light-duty vehicles and... follows: Table R99-15—Fleet Average Non-Methane Organic Gas Standards (g/mi) for Light-Duty Vehicles and...

  2. 40 CFR 86.1710-99 - Fleet average non-methane organic gas exhaust emission standards for light-duty vehicles and...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 19 2011-07-01 2011-07-01 false Fleet average non-methane organic gas....1710-99 Fleet average non-methane organic gas exhaust emission standards for light-duty vehicles and... follows: Table R99-15—Fleet Average Non-Methane Organic Gas Standards (g/mi) for Light-Duty Vehicles and...

  3. 40 CFR 86.1710-99 - Fleet average non-methane organic gas exhaust emission standards for light-duty vehicles and...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 20 2013-07-01 2013-07-01 false Fleet average non-methane organic gas....1710-99 Fleet average non-methane organic gas exhaust emission standards for light-duty vehicles and... follows: Table R99-15—Fleet Average Non-Methane Organic Gas Standards (g/mi) for Light-Duty Vehicles and...

  4. 75 FR 34927 - Safety Zone; Parade of Ships, Seattle SeaFair Fleet Week, Pier 66, Elliott Bay, WA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-21

    ...-AA00 Safety Zone; Parade of Ships, Seattle SeaFair Fleet Week, Pier 66, Elliott Bay, WA AGENCY: Coast... Seattle SeaFair Fleet Week. This action is intended to restrict vessel traffic movement and entry into... of Ships for the annual Seattle SeaFair Fleet Week. For the purposes of this rule the Parade of Ships...

  5. Alternative Fuels Data Center: Ozinga Adds 14 Natural Gas Concrete Mixers

    Science.gov Websites

    to Its Fleet Ozinga Adds 14 Natural Gas Concrete Mixers to Its Fleet to someone by E-mail Share Alternative Fuels Data Center: Ozinga Adds 14 Natural Gas Concrete Mixers to Its Fleet on Facebook Tweet about Alternative Fuels Data Center: Ozinga Adds 14 Natural Gas Concrete Mixers to Its Fleet on Twitter Bookmark

  6. 40 CFR 86.1710-99 - Fleet average non-methane organic gas exhaust emission standards for light-duty vehicles and...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 19 2010-07-01 2010-07-01 false Fleet average non-methane organic gas....1710-99 Fleet average non-methane organic gas exhaust emission standards for light-duty vehicles and... follows: Table R99-15—Fleet Average Non-Methane Organic Gas Standards (g/mi) for Light-Duty Vehicles and...

  7. 77 FR 34215 - Special Local Regulations for Marine Events, Swim Event; Lake Gaston, Littleton, NC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-11

    ... material to the docket, call Renee V. Wright, Program Manager, Docket Operations, telephone (202) 366-9826... along the western side of Eaton Ferry Bridge to the Waterview Restaurant. A fleet of spectator vessels... operation of any support vessel participating in the event, at any time it is deemed necessary for the...

  8. Flight Hour Reductions in Fleet Replacement Pilot Training through Simulation.

    ERIC Educational Resources Information Center

    Smode, Alfred F.

    A project was undertaken to integrate the 2F87F operational flight trainer into the program for training replacement patrol plane pilots. The objectives were to determine the potential of the simulator as a substitute environment for learning aircraft tasks and to effectively utilize the simulator in pilot training. The students involved in the…

  9. Bridge Programs « Coast Guard Maritime Commons

    Science.gov Websites

    network migration impact on maritime distress and safety services Editor's note: This post was updated our blog post. Inmarsat announced that it will migrate Inmarsat-C, Mini C, and Fleet77 used for Global meeting in Washington, DC, Jan. 7-11, 2018. This post offers a condensed version of his remarks, which

  10. Case Study - Propane Bakery Delivery Step Vans

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Laughlin, M.; Burnham, A.

    2016-04-01

    A switch to propane from diesel by a major Midwest bakery fleet showed promising results, including a significant displacement of petroleum, a drop in greenhouse gases and a fuel cost savings of seven cents per mile, according to a study recently completed by the U.S. Department of Energy's Argonne National Laboratory for the Clean Cities program.

  11. Alternative Fuels Data Center: City of Hoover Fleet Boasts 200-Plus Flex

    Science.gov Websites

    Quality (CMAQ) Improvement Program. In response, the City of Hoover submitted a proposal to install a flex-fuel vehicles (FFVs) in hopes of reducing emissions and improving the region's air quality. At the : Municipal Fuel: E85 Flex Fuel Vehicles: 212 Infrastructure: Municipal E85 station Motivations: Air quality

  12. CF6 jet engine performance improvement program. Task 1: Feasibility analysis

    NASA Technical Reports Server (NTRS)

    Fasching, W. A.

    1979-01-01

    Technical and economic engine improvement concepts selected for subsequent development include: (1) fan improvement; (2) short core exhaust; (3) HP turbine aerodynamic improvement; (4) HP turbine roundness control; (5) HP turbine active clearance control; and (6) cabin air recirculation. The fuel savings for the selected engine modification concepts for the CF6 fleet are estimated.

  13. Improved Aviation Readiness and Inventory Reductions Through Repair Cycle Time Reductions Using Modeling and Simulation.

    DTIC Science & Technology

    1997-12-01

    three NADEP’s within the continental United States and fleet repair sites in Italy and Japan. These facilities are located to support specific...number order. This same morning, P&E’s have a last opportunity to edit the induction file through the Planner and Estimator Cancellation Program ( PECAN

  14. Richard Nixon's "Pragmatic" Space Race: Metaphorically Crafting a National Identity.

    ERIC Educational Resources Information Center

    Krug, Linda T.

    President Richard Nixon decided in 1970 to commission the construction of a fleet of reusable space shuttles. Nixon's rhetoric on the space shuttle program (examined here in the light of Kenneth Burke's theory of symbolic action) shows how a philosophy of pragmatism was crafted out of a philosophy of wonderment. That one cannot now remember…

  15. MD PHEV/EV ARRA Project Data Collection and Reporting (Presentation)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Walkowicz, K.; Ramroth, L.; Duran, A.

    2012-01-01

    This presentation describes a National Renewable Energy Laboratory project to collect and analyze commercial fleet deployment data from medium-duty plug-in hybrid electric and all-electric vehicles that were deployed using funds from the American Recovery and Reinvestment Act. This work supports the Department of Energy's Vehicle Technologies Program and its Advanced Vehicle Testing Activity.

  16. Study of turbofan engines designed for low energy consumption

    NASA Technical Reports Server (NTRS)

    Gray, D. E.

    1976-01-01

    The near-term technology improvements which can reduce the fuel consumed in the JT9D, JT8D, and JT3D turbofans in commercial fleet operation through the 1980's are identified. Projected technology advances are identified and evaluated for new turbofans to be developed after 1985. Programs are recommended for developing the necessary technology.

  17. Fleet logistics system : data administration plans and procedures manual

    DOT National Transportation Integrated Search

    1996-01-23

    This manual provides data administration (DA) procedures for developers and maintainers of Coast Guard fleet logistics information systems. Fleet logistics includes a community of supply, logistics, maintenance, and shipboard functions. The informati...

  18. NASA airframe structural integrity program

    NASA Technical Reports Server (NTRS)

    Harris, Charles E.

    1991-01-01

    NASA has initiated a research program with the long-term objective of supporting the aerospace industry in addressing issues related to the aging commercial transport fleet. The interdisciplinary program combines advanced fatigue crack growth prediction methodology with innovative nondestructive examination technology with the focus on multi-site damage (MSD) at riveted connections. A fracture mechanics evaluation of the concept of pressure proof testing the fuselage to screen for MSD has been completed. Also, a successful laboratory demonstration of the ability of the thermal flux method to detect disbonds at riveted lap splice joints has been conducted. All long-term program elements have been initiated and the plans for the methodology verification program are being coordinated with the airframe manufacturers.

  19. NASA airframe structural integrity program

    NASA Technical Reports Server (NTRS)

    Harris, Charles E.

    1990-01-01

    NASA initiated a research program with the long-term objective of supporting the aerospace industry in addressing issues related to the aging of the commercial transport fleet. The program combines advanced fatigue crack growth prediction methodology with innovative nondestructive examination technology with the focus on multi-stage damage (MSD) at rivited connections. A fracture mechanics evaluation of the concept of pressure proof testing the fuselage to screen for MSD was completed. A successful laboratory demonstration of the ability of the thermal flux method to detect disbonds at rivited lap splice joints was conducted. All long-term program elements were initiated, and the plans for the methodology verification program are being coordinated with the airframe manufacturers.

  20. NASA advanced turboprop research and concept validation program

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Whitlow, J.B. Jr.; Sievers, G.K.

    1988-01-01

    NASA has determined by experimental and analytical effort that use of advanced turboprop propulsion instead of the conventional turbofans in the older narrow-body airline fleet could reduce fuel consumption for this type of aircraft by up to 50 percent. In cooperation with industry, NASA has defined and implemented an Advanced Turboprop (ATP) program to develop and validate the technology required for these new high-speed, multibladed, thin, swept propeller concepts. This paper presents an overview of the analysis, model-scale test, and large-scale flight test elements of the program together with preliminary test results, as available.

  1. Persistent Identifiers for Field Expeditions: A Next Step for the US Oceanographic Research Fleet

    NASA Astrophysics Data System (ADS)

    Arko, Robert; Carbotte, Suzanne; Chandler, Cynthia; Smith, Shawn; Stocks, Karen

    2016-04-01

    Oceanographic research cruises are complex affairs, typically requiring an extensive effort to secure the funding, plan the experiment, and mobilize the field party. Yet cruises are not typically published online as first-class digital objects with persistent, citable identifiers linked to the scientific literature. The Rolling Deck to Repository (R2R; info@rvdata.us) program maintains a master catalog of oceanographic cruises for the United States research fleet, currently documenting over 6,000 expeditions on 37 active and retired vessels. In 2015, R2R started routinely publishing a Digital Object Identifier (DOI) for each completed cruise. Cruise DOIs, in turn, are linked to related persistent identifiers where available including the Open Researcher and Contributor ID (ORCID) for members of the science party, the International Geo Sample Number (IGSN) for physical specimens collected during the cruise, the Open Funder Registry (FundRef) codes that supported the experiment, and additional DOIs for datasets, journal articles, and other products resulting from the cruise. Publishing a persistent identifier for each field expedition will facilitate interoperability between the many different repositories that hold research products from cruises; will provide credit to the investigators who secured the funding and carried out the experiment; and will facilitate the gathering of fleet-wide altmetrics that demonstrate the broad impact of oceanographic research.

  2. c-Raf/MEK/ERK pathway controls protein kinase C-mediated p70S6K activation in adult cardiac muscle cells.

    PubMed

    Iijima, Yoshihiro; Laser, Martin; Shiraishi, Hirokazu; Willey, Christopher D; Sundaravadivel, Balasubramanian; Xu, Lin; McDermott, Paul J; Kuppuswamy, Dhandapani

    2002-06-21

    p70S6 kinase (S6K1) plays a pivotal role in hypertrophic cardiac growth via ribosomal biogenesis. In pressure-overloaded myocardium, we show S6K1 activation accompanied by activation of protein kinase C (PKC), c-Raf, and mitogen-activated protein kinases (MAPKs). To explore the importance of the c-Raf/MAPK kinase (MEK)/MAPK pathway, we stimulated adult feline cardiomyocytes with 12-O-tetradecanoylphorbol-13-acetate (TPA), insulin, or forskolin to activate PKC, phosphatidylinositol-3-OH kinase, or protein kinase A (PKA), respectively. These treatments resulted in S6K1 activation with Thr-389 phosphorylation as well as mammalian target of rapamycin (mTOR) and S6 protein phosphorylation. Thr-421/Ser-424 phosphorylation of S6K1 was observed predominantly in TPA-treated cells. Dominant negative c-Raf expression or a MEK1/2 inhibitor (U0126) treatment showed a profound blocking effect only on the TPA-stimulated phosphorylation of S6K1 and mTOR. Whereas p38 MAPK inhibitors exhibited only partial effect, MAPK-phosphatase-3 expression significantly blocked the TPA-stimulated S6K1 and mTOR phosphorylation. Inhibition of mTOR with rapamycin blocked the Thr-389 but not the Thr-421/Ser-424 phosphorylation of S6K1. Therefore, during PKC activation, the c-Raf/MEK/extracellular signal-regulated kinase-1/2 (ERK1/2) pathway mediates both the Thr-421/Ser-424 and the Thr-389 phosphorylation in an mTOR-independent and -dependent manner, respectively. Together, our in vivo and in vitro studies indicate that the PKC/c-Raf/MEK/ERK pathway plays a major role in the S6K1 activation in hypertrophic cardiac growth.

  3. RGD-containing peptides activate S6K1 through beta3 integrin in adult cardiac muscle cells.

    PubMed

    Balasubramanian, Sundaravadivel; Kuppuswamy, Dhandapani

    2003-10-24

    The enzyme p70S6 kinase (S6K1) is critical for cell growth, and we have reported its activation during cardiac hypertrophy. Because cardiac hypertrophy also involves integrin activation, we analyzed whether integrins could contribute to S6K1 activation. Using adult feline cardiomyocytes, here we report that integrin-interacting Arg-Gly-Asp (RGD) peptides activate S6K1 as observed by band shifting, kinase activity and phosphorylation at Thr-389 and Thr-421/Ser-424 of S6K1, and S6 protein phosphorylation. Perturbation of specific integrin function with blocking antibodies and by overexpressing the beta1A cytoplasmic tail revealed that beta3 but not beta1 integrin mediates the RGD-induced S6K1 activation. This activation is focal adhesion complex-independent and is accompanied by the activation of extracellular signal-regulated kinases 1/2 (ERK) and mammalian target of rapamycin (mTOR). Studies using specific inhibitors and dominant negative c-Raf expression in cardiomyocytes indicate that the S6K1 activation involves mTOR, MEK/ERK, and phosphatidylinositol 3-kinase pathways and is independent of protein kinase C and c-Raf. Finally, addition of fluorescent-labeled RGD peptide to cardiomyocytes exhibits its internalization and localization to the endocytic vesicles, and pretreatment of cardiomyocytes with endocytic inhibitors reduced the S6K1 activation. These data suggest that RGD interaction with beta3 integrin and its subsequent endocytosis trigger specific signaling pathway(s) for S6K1 activation in cardiomyocytes and that this process may contribute to hypertrophic growth and remodeling of myocardium.

  4. The role of P2X7R/ERK signaling in dorsal root ganglia satellite glial cells in the development of chronic postsurgical pain induced by skin/muscle incision and retraction (SMIR).

    PubMed

    Song, Jingnian; Ying, Yanlu; Wang, Wei; Liu, Xianguo; Xu, Xuebing; Wei, Xuhong; Ruan, Xiangcai

    2018-03-01

    The mechanisms of chronic postsurgical pain remain to be elucidated. We reported here that skin/muscle incision and retraction (SMIR), a rat model of postsurgical pain, phosphorylated the extracellular regulated protein kinases (ERK) signaling components c-Raf, MEK (ERK kinase) and ERK1/2 in lumbar 3 dorsal root ganglion (L3 DRG) in rats. Intrathecal injection of ERK specific inhibitor SCH772984 suppressed the mechanical allodynia induced by SMIR. Furthermore, SMIR upregulated tumor necrosis factor alpha (TNFα) in L3 DRG, which could be inhibited by SCH772984. Intrathecal injection of TNF antagonist Etanercept could also inhibit the mechanical allodynia and the increased ERK phosphorylation in L3 DRG induced by SMIR. In addition, immunofluorescent data showed that P2X7R was located exclusively in GFAP labeled satellite glial cells and was highly colocalized with p-ERK1/2 following SMIR. Pretreatment with P2X7R antagonist Brilliant Blue G (BBG) could also block the mechanical allodynia, inhibited the phosphorylation of c-Raf, MEK, ERK1/2, and decrease the expression of TNF-α. Finally, intrathecal injection of BzATP produced mechanical allodynia and induced ERK phosphorylation in satellite glial cells in L3 DRG. Thus, P2X7R activation in satellite glial cells in L3 DRG, leading to a positive feedback between ERK pathway activation and TNF-α production, is suggested to be involved in the induction of chronic postsurgical pain following SMIR. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. The development of a vulnerabilities indicator library for coastal flood risk management at a European scale

    NASA Astrophysics Data System (ADS)

    Owen, Damon; Viavattene, Christophe; Priest, Sally; Micou, Paula; Parker, Dennis

    2015-04-01

    Recent and historic low-frequency, high-impact events (Xynthia, Ligurian Flash Floods, the 1953 North Sea storm surge etc) have demonstrated the flood risks faced by exposed coastal areas in Europe. The hazard probability is likely to increase due to a changing climate with more frequent and violent instances of surge-driven floods, wind damage, erosion, overtopping and rain-driven flash flooding. The number and value of receptors in the coastal area also increases due to continued economic development and population growth. As part of the FP7 EU RISCKIT (Resilience-Increasing Strategies for Coasts toolkit) project, a coastal vulnerability indicator library has been produced incorporating ecosystems, built environment, human population, critical infrastructure and the overall characteristics of the coastal system. The library will include data at European, national and local levels and will be gathered, in large part, through a multitude of interviews with various members of the coastal community at 11 case study sites across Europe. The presentation will give a brief outline of the challenges in developing vulnerability indicators - particularly for countries where specific data is limited or lacking - and how the library will be organised to facilitate the use of the data. Finally, the presentation will describe how the vulnerability library will feed into a Coastal Risk Assessment Framework (CRAF). The CRAF will evaluate coastal risk at regional scale and identify "hot spots" to assist coastal practitioners to choose the best prevention, mitigation and preparedness measures for their coast. The work described in this abstract was supported by the European Community's 7th Framework Programme through the grant to the budget of RISC-KIT, contract no. 603458, and by contributions by the partner institutes.

  6. Airport-Based Alternative Fuel Vehicle Fleets

    DOT National Transportation Integrated Search

    2001-01-01

    Airports represent attractive opportunities for the expanded use of alternative fuel vehicles (AFVs). They are commonly served by dozens of fleets operating thousands of vehicles. These fleets include both ground service equipment such as tugs, tows,...

  7. Fleet equipment performance measure preventive maintenance model.

    DOT National Transportation Integrated Search

    2013-02-28

    The Texas Department of Transportation : (TxDOT) operates a large fleet of on-road and : off-road equipment. Consequently, fleet : maintenance procedures (specifically preventive : maintenance such as oil changes) represent a : significant cost to th...

  8. 41 CFR 109-39.107 - Limited exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., AND MOTOR VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.1-Establishment, Modification, and Discontinuance of Interagency Fleet Management Systems § 109-39.107 Limited exemptions. The Director, Office of... exemptions from the fleet management system. ...

  9. Optimized deployment of emission reduction technologies for large fleets.

    DOT National Transportation Integrated Search

    2011-06-01

    This research study produced an optimization framework for determining the most efficient emission : reduction strategies among vehicles and equipment in a large fleet. The Texas Department of : Transportations (TxDOTs) fleet data were utilized...

  10. CleanFleet final report. Volume 7, vehicle emissions

    DOT National Transportation Integrated Search

    1995-12-01

    CleanFleet, formally known as the South Coast Alternative Fuels Demonstration, : was a comprehensive demonstration of alternative fuel vehicles (AFVs) in daily : commercial service. Measurements of exhaust and evaporative emissions from CleanFleet va...

  11. Clean Cities case study : Barwood Cab Fleet study summary

    DOT National Transportation Integrated Search

    1999-05-21

    Barwood Cab Fleet Study Summary is the second in a new series called 'Alternative Fuel Information Case Studies', designed to present real-world experiences with alternative fuels to fleet managers and other industry stakeholders.

  12. 41 CFR 101-39.100 - General.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... FEDERAL PROPERTY MANAGEMENT REGULATIONS AVIATION, TRANSPORTATION, AND MOTOR VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.1-Establishment, Modification, and Discontinuance of Interagency Fleet Management... fleet management systems. (a) Based on these studies, the Administrator of General Services, with the...

  13. Telematics Framework for Federal Agencies: Lessons from the Marine Corps Fleet

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hodge, Cabell; Singer, Mark R.

    Executive Order 13693 requires federal agencies to acquire telematics for their light- and medium-duty vehicles as appropriate. This report is intended to help agencies that are deploying telematics systems and seeking to integrate them into their fleet management process. It provides an overview of telematics capabilities, lessons learned from the deployment of telematics in the Marine Corps fleet, and recommendations for federal fleet managers to maximize value from telematics.

  14. Fleet equipment performance measurement preventive maintenance model : final report.

    DOT National Transportation Integrated Search

    2014-04-01

    The concept of preventive maintenance is very important in the effective management and deployment of : vehicle fleets. The Texas Department of Transportation (TxDOT) operates a large fleet of on-road and offroad : equipment. Newer engines and vehicl...

  15. 41 CFR 101-39.001 - Authority.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... FEDERAL PROPERTY MANAGEMENT REGULATIONS AVIATION, TRANSPORTATION, AND MOTOR VEHICLES 39-INTERAGENCY FLEET... establishing fleet management systems to serve the needs of executive agencies; and (b) provide for the establishment, maintenance, and operation (including servicing and storage) of fleet management systems for...

  16. Ohio's first ethanol-fueled light-duty fleet

    DOT National Transportation Integrated Search

    1998-12-31

    In 1996, the State of Ohio established a : project to demonstrate the effectiveness of : ethanol as an alternative to gasoline in : fleet operations. The state purchased and : incorporated a number of flexible-fuel : vehicles (FFVs) into its fleet. F...

  17. Ares I First Stage Propulsion System Status

    NASA Technical Reports Server (NTRS)

    Priskos, Alex S.

    2010-01-01

    With the retirement of the Space Shuttle inevitable, the US is faced with the need to loft a reliable cost-effective, technologically viable solution to bring the nation s fleet of spacecraft back up to industry standard. It must not only support the International Space Station (ISS), it must also be capable of supporting human exploration beyond low Earth orbit (LEO). NASA created the Constellation Program to develop a new fleet including the launch vehicles, the spacecraft, and the mission architecture to meet those objectives. The Ares First Stage Team is tasked with developing a propulsion system capable of safely, dependably and repeatedly lofting that new fleet. To minimize technical risks and development costs, the Solid Rocket Boosters (SRBs) of Shuttle were used as a starting point in the design and production of a new first stage element. While the first stage will provide the foundation, the structural backbone, power, and control for launch, the new propulsive element will also provide a greater total impulse to loft a safer, more powerful, fleet of space flight vehicles. Substantial design and system upgrades were required to meet the mass and trajectory requisites of the new fleet. Noteworthy innovations and design features include new forward structures, new propellant grain geometry, a new internal insulation system, and a state-of-the art avionics system. Additional advances were in materials and composite structures development, case bond liners, and thermal protection systems. Significant progress has been made in the design, development and testing of the propulsion and avionics systems for the new first stage element. Challenges, such as those anticipated with thrust oscillation, have been better characterized, and are being effectively mitigated. The test firing of the first development motor (DM-1) was a success that validated much of the engineering development to date. Substantive data has been collected and analyzed, allowing the Ares First Stage team to move forward, fine-tune the design, and advance to production of the second development motor (DM-2), which is now in fabrication. This paper will provide an overview of the design, development, challenges, and progress on the production of the new Ares First Stage propulsion system

  18. Mitsubishi iMiEV: An Electric Mini-Car in NREL's Advanced Technology Vehicle Fleet (Fact Sheet)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    This fact sheet highlights the Mitsubishi iMiEV, an electric mini-car in the advanced technology vehicle fleet at the National Renewable Energy Laboratory (NREL). In support of the U.S. Department of Energy's fast-charging research efforts, NREL engineers are conducting charge and discharge performance testing on the vehicle. NREL's advanced technology vehicle fleet features promising technologies to increase efficiency and reduce emissions without sacrificing safety or comfort. The fleet serves as a technology showcase, helping visitors learn about innovative vehicles that are available today or are in development. Vehicles in the fleet are representative of current, advanced, prototype, and emerging technologies.

  19. DOE-NE Light Water Reactor Sustainability Program and EPRI Long-Term Operations Program. Joint Research and Development Plan

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Williams, Don

    2014-04-01

    Nuclear power has contributed almost 20% of the total amount of electricity generated in the United States over the past two decades. High capacity factors and low operating costs make nuclear power plants (NPPs) some of the most economical power generators available. Further, nuclear power remains the single largest contributor (nearly 70%) of non-greenhouse gas-emitting electric power generation in the United States. Even when major refurbishments are performed to extend operating life, these plants continue to represent cost-effective, low-carbon assets to the nation’s electrical generation capability. By the end of 2014, about one-third of the existing domestic fleet will havemore » passed their 40th anniversary of power operations, and about one-half of the fleet will reach the same 40-year mark within this decade. Recognizing the challenges associated with pursuing extended service life of commercial nuclear power plants, the U.S. Department of Energy’s (DOE) Office of Nuclear Energy (NE) and the Electric Power Research Institute (EPRI) have established separate but complementary research and development programs (DOE-NE’s Light Water Reactor Sustainability [LWRS] Program and EPRI’s Long-Term Operations [LTO] Program) to address these challenges. To ensure that a proper linkage is maintained between the programs, DOE-NE and EPRI executed a memorandum of understanding in late 2010 to “establish guiding principles under which research activities (between LWRS and LTO) could be coordinated to the benefit of both parties.” This document represents the third annual revision to the initial version (March 2011) of the plan as called for in the memorandum of understanding.« less

  20. Future Jet Technologies, Part C

    NASA Astrophysics Data System (ADS)

    Gal-Or, Benjamin

    2013-06-01

    This updated, PART C REVIEW, covers the dangerous global spread of JS-stealth, drone technology [1-91], canard-free, stealth, new agile drones and the highly debated, 480 billion F-35 International Program as reported on March 13, 2013 to the U.S. Congress [92]. Due to serious design issues, spiraling high costs and years in delays, alternatives are analyzed here, depicted and proposed, mainly from the propulsion-design point of view. These include fleets of low-cost, stealth, jet-steered-drones mixed with non-stealthy, low-cost, ready-to-be-delivered, U.S. or European or Russian fighter aircraft. Can a few F-35s win against large fleets of stealth agile drones? To understand the dangers and critical issues involved, the author's own, past classified information is partly disclosed, while resorting to images in Figs. 2(a) and 2(b) taken from his book [2] and from Wikipedia, the "Free Encyclopedia", in all other images.

  1. Site Operator technical report. Final report (1992--1996)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1996-12-01

    The Southern California Edison Company (SCE) and the US Department of Energy (DOE) entered into cooperative agreement No. DE-FC07-91ID13077 on August 23, 1991, which expired on August 3, 1996. This cooperative agreement provided SCE with DOE cofunding for participation in the DOE`s Electric and Hybrid Vehicle Site Operator Program. In return, SCE provided the DOE with quarterly progress reports which include operating and maintenance data for the electric (EVs) vehicles in SCE`s fleet. Herein is SCE`s final report for the 1992 to 1996 agreement period. As of September 1, 1996 the SCE fleet had 65 electric vehicles in service. Amore » total of 578,200 miles had been logged. During the agreement period, SCE sent the DOE a total of 19 technical reports (Appendix B). This report summarizes the technical achievements which took place during a long, productive and rewarding, relationship with the DOE.« less

  2. Ares V: Progress Towards a Heavy Lift Capability for the Moon and Beyond

    NASA Technical Reports Server (NTRS)

    Creech, Steve

    2008-01-01

    NASA's new exploration initiative will again take humans beyond low Earth orbit, to the moon, and into deep space. The space agency is developing a new fleet of launch vehicles that will fulfill the national goals of replacing the Space Shuttle fleet, completing the International Space Station, establishing a permanent outpost on the moon, and eventually traveling to Mars. Separate crew and cargo vehicles emerged from mission architecture studies - the Ares I to carry the Orion crew exploration vehicle and its crew of4 to 6 astronauts, and the Ares V to carry the Altair lunar lander or other supplies to support future exploration missions. (Figure 1) These vehicles will be designed to be safe, affordable, sustainable, reliable, operable with the safety, reliability, flexibility, and operability to serve this nation's manned and unmanned exploration programs for the coming decades. This paper discusses recent and current progress on the Ares V and planned future activities.

  3. U.S. Air Force Energy Program

    DTIC Science & Technology

    2011-05-01

    prepared to acquire 50% of domestic aviation fuel requirements via an alternative fuel blend by 2016 Installation Energy  Reduce energy intensity by...FY10  On track to certify fleet on synthetic fuel blend by early 2011 Installation Energy  Reduced installation energy intensity nearly 15% since... Winglets Manufacturing Methods Propulsion Integration Alt Fuels Analysis New Efficient Engines Legacy Aircraft Energy Harvesting Weight-optimized

  4. 75 FR 32993 - Fisheries Off West Coast States; Pacific Coast Groundfish Fishery Management Plan; Amendments 20...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-10

    ... for illegal landings will not count for allocation of QS. Landings made under non-whiting Experimental... individual fishing quota (IFQ) program for the shore-based trawl fleet (including whiting and non-whiting..., or vessels may choose to fish in a non-coop fishery which would be unaffiliated with a coop. For the...

  5. Capital Requirements for the Air Transport Industry

    NASA Technical Reports Server (NTRS)

    James, G. W.

    1972-01-01

    In recent years the U.S. scheduled airline industry has been involved in the largest re-equipment program that involves the addition of hundreds of new aircraft to the airline fleet. The costs associated with the purchase of this new equipment, along with the other costs involving such matters as the environment and security, are presenting the carriers with significant financial challenges.

  6. Coast Guard Deepwater Program: Background, Oversight Issues, and Options for Congress

    DTIC Science & Technology

    2007-02-20

    NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e . TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Congressional...Appendix E: NGSS Testimony . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39 Appendix F: Lockheed Martin Testimony...stopped at eight hulls (rather than the entire fleet of 49) due to deck cracking, hull buckling, and shaft alignment problems. These patrol boat

  7. Network Centric Warfare in the U.S. Navy’s Fifth Fleet. Network-Supported Operational Level Command and Control in Operation Enduring Freedom

    DTIC Science & Technology

    2004-06-01

    Mark Adkins Director of Research Ph.D Human Communication adkins@arizona.edu Dr. John Kruse Director of Programming Ph.D Management Information Systems...Theory • Network Centric Warfare • Technology Adoption – Technology Adoption Model – Technology Transition Model • Human Communication – Social Context

  8. The Development and Evaluation of Training Methods for Group IV Personnel. 1. Orientation and Implementation of the Training Methods Development School (TMDS).

    ERIC Educational Resources Information Center

    Steinemann, John H.

    The investigation is part of continuing Navy research on the Trainability of Group IV (low ability) personnel intended to maximize the utilization and integration of marginal personnel in the fleet. An experimental Training Methods Development School (TMDS) was initiated to provide an experimental training program, with research controls, for…

  9. Fleet Readiness Center - Southeast Technology Development Program (Cadmium & Hexavalent Chromium Reduction)

    DTIC Science & Technology

    2014-11-01

    Industrial Waste Water Treatment  Aircraft & Component Paint Removal (ABM & Chemical)  Chrome Electroplating  Corrosion Treatment  Aircraft...Hex Chrome post treatment )  Energy Use; Electrical (& Steam)  NDI- Florescent Penetrant  Solvent Tank Cleaning  Water (& Sanitary) Use...Engineer Corrosion Science & Engineering NAVAIR Jacksonville Phone: (904) 790-6405 Email: john.benfer@navy.mil ASETS Technical Workshop (NOV

  10. Fleet Astronomy

    NASA Astrophysics Data System (ADS)

    Klebe, D. I.; Colorado College Student Astronomy Instrument Team; Pikes Peak Observatory Team

    1999-12-01

    The Colorado College Student Astronomy Instrument Team (CCSAIT) and the Pikes Peak Observatory (PPO) present preliminary optical and mechanical designs as well as discussion on a fleet of small research-class 0.4-0.5-meter telescopes. Each telescope is being designed to accommodate a variety of visible and near-infrared instrumentation, ranging from wide-field imaging cameras to moderate resolution spectrometers. The design of these telescopes is predicated on the use of lightweight primary mirrors, which will enable the entire optical telescope assembly (OTA) including instrumentation to come in under 50 kilograms. The lightweight OTA’s will further allow the use of inexpensive high-quality off-the-shelf robotic telescope mounts for future access and computer control of these telescopes over the Internet. The basic idea is to provide astronomers with a comprehensive arsenal of modest instrumentation at their fingertips in order to conduct a wide variety of interesting scientific research programs. Some of these research programs are discussed and input from the astronomical community is strongly encouraged. Connectivity and Internet control issues are also briefly discussed as development in this area is already underway through a collaborative effort between the PPO and the Cowan-Fouts Foundation of Woodland Park, Colorado.

  11. U.S. Department of Energy FreedomCAR & Vehicle Technologies Program Oil Bypass Filter Technology Evaluation Fifth Quarterly Report October - December 2003

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Larry Zirker; James Francfort

    2004-02-01

    This Oil Bypass Filter Technology Evaluation quarterly report (October-December 2003) details the ongoing fleet evaluation of an oil bypass filter technology by the Idaho National Engineering and Environmental Laboratory (INEEL) for the U.S. Department of Energy's FreedomCAR & Vehicle Technologies Program. Eight four-cycle diesel-engine buses used to transport INEEL employees on various routes have been equipped with oil bypass filter systems from the puraDYN Corporation. The bypass filters are reported to have engine oil filtering capability of <1 micron and a built-in additive package to facilitate extended oil-drain intervals. To date, the eight buses have accumulated 324,091 test miles. Thismore » represents an avoidance of 27 oil changes, which equate to 952 quarts (238 gallons) of new oil not conserved and therefore, 952 quarts of waste oil not generated. To validate the extended oil-drain intervals, an oil-analysis regime is used to evaluate the fitness of the oil for continued service by monitoring the presence of necessary additives, undesirable contaminants, and engine-wear metals. The test fleet has been expanded to include six Chevrolet Tahoe sport utility vehicles with gasoline engines.« less

  12. NASA's Subsonic Jet Transport Noise Reduction Research

    NASA Technical Reports Server (NTRS)

    Powell, Clemans A.; Preisser, John S.

    2000-01-01

    Although new jet transport airplanes in today s fleet are considerably quieter than the first jet transports introduced about 40 years ago, airport community noise continues to be an important environmental issue. NASA s Advanced Subsonic Transport (AST) Noise Reduction program was begun in 1994 as a seven-year effort to develop technology to reduce jet transport noise 10 dB relative to 1992 technology. This program provides for reductions in engine source noise, improvements in nacelle acoustic treatments, reductions in the noise generated by the airframe, and improvements in the way airplanes are operated in the airport environs. These noise reduction efforts will terminate at the end of 2001 and it appears that the objective will be met. However, because of an anticipated 3-8% growth in passenger and cargo operations well into the 21st Century and the slow introduction of new the noise reduction technology into the fleet, world aircraft noise impact will remain essentially constant until about 2020 to 2030 and thereafter begin to rise. Therefore NASA has begun planning with the Federal Aviation Administration, industry, universities and environmental interest groups in the USA for a new noise reduction initiative to provide technology for significant further reductions.

  13. DOE Office of Scientific and Technical Information (OSTI.GOV)

    None, None

    Document contains guidance on the federal fleet requirements of Executive Order 13693: Planning for Federal Sustainability in the Next Decade and helps federal agencies subject to the executive order develop an overall approach for reducing total fleet greenhouse gas (GHG) emissions and fleet-wide per-mile GHG emissions.

  14. Municipal Fleet Vehicle Electrification and Photovoltaic Power In the City of Pittsburgh.

    DOT National Transportation Integrated Search

    2016-01-01

    This document reports the results of a cost benefit analysis on potential photovoltaic projects : in Pittsburgh and electrifying the citys light duty civilian vehicle fleet. Currently the : city of Pittsburgh has a civilian passenger vehicle fleet...

  15. 48 CFR 51.201 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... GOVERNMENT SOURCES BY CONTRACTORS Contractor Use of Interagency Fleet Management System (IFMS) 51.201 Policy... contractors to obtain, for official purposes only, interagency fleet management system (IFMS) vehicles and... instance. (c) Government contractors shall not be authorized to obtain interagency fleet management system...

  16. 41 CFR 101-39.003 - Financing.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... FEDERAL PROPERTY MANAGEMENT REGULATIONS AVIATION, TRANSPORTATION, AND MOTOR VEHICLES 39-INTERAGENCY FLEET..., and operation of fleet management systems. (b) When an agency other than GSA operates an interagency fleet management system, the financing and accounting methods shall be developed by GSA in cooperation...

  17. CleanFleet final report. Volume 2, project design and implementation

    DOT National Transportation Integrated Search

    1995-12-01

    The South Coast Alternative Fuels Demonstration, called CleanFleet, was conducted in the Los Angeles area from April 1992 through September 1994. The project evaluated five alternative motor fuels in commercial fleet service over a two-year period. T...

  18. Reserve fleet manual [3rd ed., 1st rev.

    DOT National Transportation Integrated Search

    2003-03-17

    The purpose of this document is to provide policy to the Regional Headquarters regarding vessel maintenance in the National Defense Reserve Fleet anchorages (fleet sites). This policy is for the acceptance of ships into, the maintenance of ships in, ...

  19. Potential applications of MMC and aluminum-lithium alloys in cameras for CRAF spacecraft. [Comet Rendezvous Asteroid Flyby Mission

    NASA Technical Reports Server (NTRS)

    Lane, Marc; Hsieh, Cheng; Adams, Lloyd

    1989-01-01

    In undertaking the design of a 2000-mm focal length camera for the Mariner Mark II series of spacecraft, JPL sought novel materials with the requisite dimensional and thermal stability, outgassing and corrosion resistance, low mass, high stiffness, and moderate cost. Metal-matrix composites and Al-Li alloys have, in addition to excellent mechanical properties and low density, a suitably low coefficient of thermal expansion, high specific stiffness, and good electrical conductivity. The greatest single obstacle to application of these materials to camera structure design is noted to have been the lack of information regarding long-term dimensional stability.

  20. Integrated operations/payloads/fleet analysis. Volume 3: System costs. Appendix A: Program direct costs

    NASA Technical Reports Server (NTRS)

    1971-01-01

    Individualized program direct costs for each satellite program are presented. This breakdown provides the activity level dependent costs for each satellite program. The activity level dependent costs, or, more simply, program direct costs, are comprised of the total payload costs (as these costs are strictly program dependent) and the direct launch vehicle costs. Only those incremental launch vehicle costs associated directly with the satellite program are considered. For expendable launch vehicles the direct costs include the vehicle investment hardware costs and the launch operations costs. For the reusable STS vehicles the direct costs include only the launch operations, recovery operations, command and control, vehicle maintenance, and propellant support. The costs associated with amortization of reusable vehicle investment, RDT&E range support, etc., are not included.

  1. High-Mileage Light-Duty Fleet Vehicle Emissions: Their Potentially Overlooked Importance.

    PubMed

    Bishop, Gary A; Stedman, Donald H; Burgard, Daniel A; Atkinson, Oscar

    2016-05-17

    State and local agencies in the United States use activity-based computer models to estimate mobile source emissions for inventories. These models generally assume that vehicle activity levels are uniform across all of the vehicle emission level classifications using the same age-adjusted travel fractions. Recent fuel-specific emission measurements from the SeaTac Airport, Los Angeles, and multi-year measurements in the Chicago area suggest that some high-mileage fleets are responsible for a disproportionate share of the fleet's emissions. Hybrid taxis at the airport show large increases in carbon monoxide, hydrocarbon, and oxide of nitrogen emissions in their fourth year when compared to similar vehicles from the general population. Ammonia emissions from the airport shuttle vans indicate that catalyst reduction capability begins to wane after 5-6 years, 3 times faster than is observed in the general population, indicating accelerated aging. In Chicago, the observed, on-road taxi fleet also had significantly higher emissions and an emissions share that was more than double their fleet representation. When compounded by their expected higher than average mileage accumulation, we estimate that these small fleets (<1% of total) may be overlooked as a significant emission source (>2-5% of fleet emissions).

  2. 41 CFR 101-39.300 - General.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... FEDERAL PROPERTY MANAGEMENT REGULATIONS AVIATION, TRANSPORTATION, AND MOTOR VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.3-Use and Care of GSA Interagency Fleet Management System Vehicles § 101-39.300 General. (a) The objective of the General Services Administration (GSA) Interagency Fleet Management System...

  3. 41 CFR 101-39.302 - Rotation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... FEDERAL PROPERTY MANAGEMENT REGULATIONS AVIATION, TRANSPORTATION, AND MOTOR VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.3-Use and Care of GSA Interagency Fleet Management System Vehicles § 101-39.302 Rotation. GSA Interagency Fleet Management System (IFMS) vehicles on high mileage assignments may be...

  4. 41 CFR 109-39.103 - Agency appeals.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., AND MOTOR VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.1-Establishment, Modification, and Discontinuance of Interagency Fleet Management Systems § 109-39.103 Agency appeals. The Director, Office of... request exemption from, a determination made by GSA concerning the establishment of a fleet management...

  5. 48 CFR 51.203 - Means of obtaining service.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... MANAGEMENT USE OF GOVERNMENT SOURCES BY CONTRACTORS Contractor Use of Interagency Fleet Management System... interagency fleet management system (IFMS) vehicles and related services in writing to the appropriate GSA regional Federal Supply Service Bureau, Attention: Regional fleet manager, except that requests for more...

  6. 41 CFR 101-39.403 - Investigation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... FEDERAL PROPERTY MANAGEMENT REGULATIONS AVIATION, TRANSPORTATION, AND MOTOR VEHICLES 39-INTERAGENCY FLEET... Interagency Fleet Management System (IFMS) vehicle shall be investigated and a report furnished to the manager of the GSA IFMS fleet management center which issued the vehicle. (b) The agency employing the...

  7. 48 CFR 51.205 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... USE OF GOVERNMENT SOURCES BY CONTRACTORS Contractor Use of Interagency Fleet Management System (IFMS... Fleet Management System (IFMS) Vehicles and Related Services, in solicitations and contracts when a cost... interagency fleet management system (IFMS) vehicles and related services. [48 FR 42476, Sept. 19, 1983, as...

  8. A Manpower Comparison of Three U.S. Navies: The Current Fleet, a Projected 313 Ship Fleet, and a More Distributed Bimodal Alternative

    DTIC Science & Technology

    2009-09-01

    Large, Medium-speed, Roll-on/Roll-off Ships T- AKR ,” 2009) The ships can support humanitarian missions as well. LMSRs normally have a crew size of 26...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release; distribution is unlimited A MANPOWER...COMPARISON OF THREE U. S. NAVIES: THE CURRENT FLEET, A PROJECTED 313 SHIP FLEET, AND A MORE DISTRIBUTED BIMODAL ALTERNATIVE by Juan L. Carrasco

  9. Navy Force Structure: A Bigger Fleet Background and Issues for Congress

    DTIC Science & Technology

    2016-10-20

    20, 2016; Hope Hodge Seck, “Overtaxed Fleet Needs Shorter Deployments,” Military.com, March 19, 2016; David Larter, “Carrier Scramble: CENTCOM, PACOM...example, Hope Hodge Seck, “CNO: Navy to Hit Seven-Month Deployments by End of Year,” Military.com, February 12, 2016; Chris Church, “Analysts: Truman...Will Harm the Fleet,” Navy Times, April 20, 2016; Hope Hodge Seck, “Overtaxed Fleet Needs Shorer Deployments,” Military.com, March 19, 2016; Bryan

  10. KSC All Hands

    NASA Image and Video Library

    2018-01-11

    Mic Woltman, chief of the Fleet Systems Integration Branch of NASA's Launch Services Program, speaks to Kennedy Space Center employees about plans for the coming year. The event took place in the Lunar Theater at the Kennedy Space Center Visitor Complex’s Apollo Saturn V Center. The year will be highlighted with NASA's partners preparing test flights for crewed missions to the International Space Station as part of the agency's Commercial Crew Program and six launches by the Launch Services Program. Exploration Ground Systems will be completing facilities to support the Space Launch System rocket and Orion spacecraft. Exploration Research and Technology Programs will continue to provide supplies to the space station launched as part of the Commercial Resupply Services effort.

  11. Toyota Prius Plug-In HEV: A Plug-In Hybrid Electric Car in NREL's Advanced Technology Vehicle Fleet (Fact Sheet)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    This fact sheet highlights the Toyota Prius plug-in HEV, a plug-in hybrid electric car in the advanced technology vehicle fleet at the National Renewable Energy Laboratory (NREL). In partnership with the University of Colorado, NREL uses the vehicle for grid-integration studies and for testing new hardware and charge-management algorithms. NREL's advanced technology vehicle fleet features promising technologies to increase efficiency and reduce emissions without sacrificing safety or comfort. The fleet serves as a technology showcase, helping visitors learn about innovative vehicles that are available today or are in development. Vehicles in the fleet are representative of current, advanced, prototype, andmore » emerging technologies.« less

  12. Hybrid Taxis Give Fuel Economy a Lift, Clean Cities, Fleet Experiences, April 2009 (Fact Sheet)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    2009-04-01

    Clean Cities helped Boston, San Antonio, and Cambridge create hybrid taxi programs. The hybrid taxis are able to achieve about twice the gas mileage of a conventional taxi while helping cut gasoline use and fuel costs. Tax credits and other incentives are helping both company owners and drivers make the switch to hybrids. Program leaders have learned some important lessons other cities can benefit from including learning a city's taxi structure, relaying benefits to drivers, and understanding the needs of owners.

  13. Plug-In Electric Vehicle Handbook for Fleet Managers (Brochure)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    2012-04-01

    Plug-in electric vehicles (PEVs) are entering the automobile market and are viable alternatives to conventional vehicles. This guide for fleet managers describes the basics of PEV technology, PEV benefits for fleets, how to select the right PEV, charging a PEV, and PEV maintenance.

  14. 48 CFR 970.2307-1 - Motor vehicle fleet operations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Environment, Energy and Water Efficiency... that the Federal motor vehicle fleet will serve as an example and provide a leadership role in the... management contracts which include Federal motor vehicle fleet operations. Section 506 of Executive Order...

  15. Telematics Options and Capabilities

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hodge, Cabell

    This presentation describes the data tracking and analytical capabilities of telematics devices. Federal fleet managers can use the systems to keep their drivers safe, maintain a fuel efficient fleet, ease their reporting burden, and save money. The presentation includes an example of how much these capabilities can save fleets.

  16. 41 CFR 101-39.104-1 - Consolidations into a fleet management system.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... fleet management system. 101-39.104-1 Section 101-39.104-1 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS AVIATION, TRANSPORTATION, AND MOTOR VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.1-Establishment, Modification, and...

  17. Commercial vehicle fleet management and information systems. Technical memorandum 2 : summary of case study interviews

    DOT National Transportation Integrated Search

    1997-10-01

    The FHWA has commissioned the Commercial Vehicle Fleet Management and Information Systems study to determine if there are fleet management needs that the public sector can address through the development of ITS for commercial vehicle operations. As p...

  18. 41 CFR 101-39.105-2 - Agency requests to withdraw participation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., AND MOTOR VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.1-Establishment, Modification, and Discontinuance of Interagency Fleet Management Systems § 101-39.105-2 Agency requests to withdraw participation. (a) Executive agencies receiving motor vehicle services from fleet management systems may request...

  19. 41 CFR 109-39.106 - Unlimited exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., AND MOTOR VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.1-Establishment, Modification, and Discontinuance of Interagency Fleet Management Systems § 109-39.106 Unlimited exemptions. The Director, Office of... determination that an unlimited exemption from inclusion of a motor vehicle in a fleet management system is...

  20. Alternative Fuels Data Center: Tools

    Science.gov Websites

    Calculator Compare cost of ownership and emissions for most vehicle models. mobile Petroleum Reduction ROI and payback period for natural gas vehicles and infrastructure. AFLEET Tool Calculate a fleet's , hydrogen, or fuel cell infrastructure. GREET Fleet Footprint Calculator Calculate your fleet's petroleum

  1. Game Theory in Fleet Management

    NASA Astrophysics Data System (ADS)

    Dulai, Tibor; Jaskó, Szilárd; Muhi, Dániel

    2008-11-01

    In this survey we attempt to apply the results of cooperative game theory on fleet management problems. We deal with the aspect of a fleet where the members have their own goal, however the fleet has a common purpose too. These goals are to reach all destinations and get back to the center as quickly as possible. If we draw the map of the area-which contains the destination points and their environment-as a graph, we should determinate circles in it for each member of the fleet. Separating the nodes for each member, we should find Hamilton-circles of the sub-graphs. How to separate the destination points between the fleet members? How to route the members? What happens if there is an accident on a road which changes the way of a member? It may influence the other members' route too. What to communicate for getting the relevant information? How to change the routes in real time? We use cooperative game theory to find the solution.

  2. Developing a dispersant spraying capability

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gill, S.D.

    1979-01-01

    In developing a national dispersant spraying capability, the Canadian Coast Guard (CCG) has undertaken a modification program to enable the conventional offshore spraying gear to be mounted on almost any vessel of convenience. Smaller, more versatile inshore spraying vessels and pumps have been designed and built. With the popularization of concentrated dispersants, the inshore pumping equipment can be used aboard hovercraft for special application situations. A program of acquiring mobile dispersant storage tanks has been undertaken with auxiliary equipment that will facilitate the shipment of dispersants in bulk by air freight. Work also has commenced on extending the dispersant applicationmore » program to include the CCG fleet of helicopters.« less

  3. Sandia National Laboratories, California Environmental Management System program manual.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Larsen, Barbara L.

    2012-03-01

    The Sandia National Laboratories, California (SNL/CA) Environmental Management System (EMS) Program Manual documents the elements of the site EMS Program. The SNL/CA EMS Program conforms to the International Standard on Environmental Management Systems, ISO 14001:2004and Department of Energy (DOE) Order 436.1. Sandia National Laboratories, California (SNL/CA) has maintained functional environmental programs to assist with regulatory compliance for more than 30 years. During 2005, these existing programs were rolled into a formal environmental management system (EMS) that expands beyond the traditional compliance focus to managing and improving environmental performance and stewardship practices for all site activities. An EMS is a setmore » of inter-related elements that represent a continuing cycle of planning, implementing, evaluating, and improving processes and actions undertaken to achieve environmental policy and goals. The SNL/CA EMS Program conforms to the International Standard for Environmental Management Systems, ISO 14001:2004 (ISO 2004). The site first received ISO 14001 certification in September 2006 and recertification in 2009. SNL/CA's EMS Program is applicable to the Sandia, Livermore site only. Although SNL/CA operates as one organizational division of the overall Sandia National Laboratories, the EMS Program is site-specific, with site-specific objectives and targets. SNL/CA (Division 8000) benefits from the organizational structure as it provides corporate level policies, procedures, and standards, and established processes that connect to and support elements of the SNL/CA EMS Program. Additionally, SNL/CA's EMS Program benefits from two corporate functional programs (Facilities Energy and Water Resource Management and Fleet Services programs) that maintain responsibility for energy management and fleet services for all Sandia locations. Each EMS element is further enhanced with site-specific processes and standards. Division 8000 has several groups operating at Sandia National Laboratories, New Mexico (SNL/NM). Although these groups, from an organizational perspective, are part of Division 8000, they are managed locally and fall under the environmental requirements specific to their New Mexico location. The New Mexico groups in Division 8000 follow the corporate EMS Program for New Mexico operations.« less

  4. Clean Cities Plug-In Electric Vehicle Handbook for Fleet Managers

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    2012-04-01

    Plug-in electric vehicles (PEVs) are entering the automobile market and are viable alternatives to conventional vehicles. This guide for fleet managers describes the basics of PEV technology, PEV benefits for fleets, how to select the right PEV, charging a PEV, and PEV maintenance.

  5. Alternative Fuels Data Center

    Science.gov Websites

    advanced lean burn vehicles. Fleets that use fuel blends containing at least 20% biodiesel (B20) may earn Energy Independence and Security Act of 2007, including fleet management plan requirements (Section 142 infrastructure installation requirements (Section 246). For more information, see the Federal Fleet Management

  6. 41 CFR 101-39.105 - Discontinuance or curtailment of service.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., AND MOTOR VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.1-Establishment, Modification, and Discontinuance of Interagency Fleet Management Systems § 101-39.105 Discontinuance or curtailment of service. (a... efficiencies are realized from the operation of any fleet management system, the Administrator, GSA, will...

  7. 41 CFR 109-39.101-1 - Agency cooperation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., AND MOTOR VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.1-Establishment, Modification, and Discontinuance of Interagency Fleet Management Systems § 109-39.101-1 Agency cooperation. The Director, Office of... representatives to coordinate with GSA concerning the establishment of a GSA fleet management system to serve...

  8. 41 CFR 109-39.105-2 - Agency requests to withdraw participation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... AVIATION, TRANSPORTATION, AND MOTOR VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.1-Establishment, Modification, and Discontinuance of Interagency Fleet Management Systems § 109-39.105-2 Agency requests to... of participation by a DOE organization of a given interagency fleet management system, the...

  9. 48 CFR 251.205 - Contract clause.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Fleet Management System (IFMS) Vehicles 251.205 Contract clause. Use the clause at 252.251-7001, Use of Interagency Fleet Management System (IFMS)Vehicles and Related Services, in solicitations and contracts which include the clause at FAR 52.251-2, Interagency Fleet Management System (IFMS) Vehicles and Related...

  10. 41 CFR 101-39.201 - Services available.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.2-GSA Interagency Fleet Management System Services § 101-39.201 Services available. GSA Interagency Fleet Management System (IFMS) vehicles and services shall be used in... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Services available. 101...

  11. 49 CFR 531.5 - Fuel economy standards.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PASSENGER AUTOMOBILE AVERAGE FUEL ECONOMY STANDARDS § 531.5 Fuel... automobiles shall comply with the fleet average fuel economy standards in Table I, expressed in miles per... passenger automobile fleet shall comply with the fleet average fuel economy level calculated for that model...

  12. 49 CFR 531.5 - Fuel economy standards.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PASSENGER AUTOMOBILE AVERAGE FUEL ECONOMY STANDARDS § 531.5 Fuel... automobiles shall comply with the fleet average fuel economy standards in Table I, expressed in miles per... passenger automobile fleet shall comply with the fleet average fuel economy level calculated for that model...

  13. 41 CFR 101-39.104 - Notice of establishment of a fleet management system.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... management system in order to work out any problems pertaining to establishing and operating fleet management... of a fleet management system. 101-39.104 Section 101-39.104 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS AVIATION...

  14. 41 CFR 101-39.104 - Notice of establishment of a fleet management system.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... management system in order to work out any problems pertaining to establishing and operating fleet management... of a fleet management system. 101-39.104 Section 101-39.104 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS AVIATION...

  15. 41 CFR 101-39.104 - Notice of establishment of a fleet management system.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... management system in order to work out any problems pertaining to establishing and operating fleet management... of a fleet management system. 101-39.104 Section 101-39.104 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS AVIATION...

  16. 41 CFR 101-39.104 - Notice of establishment of a fleet management system.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... management system in order to work out any problems pertaining to establishing and operating fleet management... of a fleet management system. 101-39.104 Section 101-39.104 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS AVIATION...

  17. ARMY CYBER STRUCTURE ALIGNMENT

    DTIC Science & Technology

    2016-02-16

    Director of Navy Staff Vice Admiral J. M. Bird , Missions, Functions, and Tasks of Commander, U.S. Fleet Cyber Command and Commander, U.S. Tenth Fleet...www.doncio.navy.mil/ContentView.aspx?ID=649. Director of Navy Staff Vice Admiral J. M. Bird , Missions, Functions, and Tasks of Commander, U.S. Fleet Cyber

  18. 75 FR 11880 - California State Nonroad Engine Pollution Control Standards; California Nonroad Compression...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-12

    ... EPA that it has adopted amendments to its emission standards for fleets that operate nonroad, diesel..., CARB requested that EPA authorize California to enforce its In-Use Off-Road Diesel-Fueled Fleets... through 2449.3). CARB's regulations require fleets that operate nonroad, diesel-fueled equipment with...

  19. 41 CFR 101-39.304 - Modification or installation of accessory equipment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., TRANSPORTATION, AND MOTOR VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.3-Use and Care of GSA Interagency Fleet Management System Vehicles § 101-39.304 Modification or installation of accessory equipment. The modification of a GSA Interagency Fleet Management System (IFMS) vehicle or the permanent installation of...

  20. 41 CFR 101-39.206 - Seasonal or unusual requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.2-GSA Interagency Fleet Management System Services... requirements for vehicles or related services shall inform the GSA IFMS fleet management center as far in... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Seasonal or unusual...

  1. 41 CFR 101-39.102-1 - Records, facilities, personnel, and appropriations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., TRANSPORTATION, AND MOTOR VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.1-Establishment, Modification, and Discontinuance of Interagency Fleet Management Systems § 101-39.102-1 Records, facilities, personnel, and appropriations. (a) If GSA decides to establish a fleet management system, GSA, with the assistance of the...

  2. 41 CFR 109-39.300 - General.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.3-Use and Care of GSA Interagency Fleet Management System... operators and passengers in GSA Interagency Fleet Management System (IFMS) motor vehicles are aware of the... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false General. 109-39.300...

  3. Commercial Vehicle Fleet Management And Information Systems, Technical Memorandum 1, Classification Of Fleet Operations, And Selection Of Candidate Case-Study Fleets

    DOT National Transportation Integrated Search

    1994-11-04

    THE ECONOMIC WELL-BEING AND COMPETITIVENESS OF THE U.S. ECONOMY DEPEND HEAVILY ON RELIABLE AND EFFICIENT FREIGHT MOVEMENTS. TRUCKING ACCOUNTS FOR ABOUT 75 PERCENT ($270 BILLION) OF THE $350 BILLION SPENT ANNUALLY ON FREIGHT TRANSPORTATION. THE APPLIC...

  4. Analysis of required fleet size and private sector cost comparisons for the USCG inland construction tender fleet : final report

    DOT National Transportation Integrated Search

    1994-05-01

    This report documents an analysis performed in support of the United States Coast Guard in managing its fleet of construction tenders (WLICs). The project was sponsored by the Coast Guard's Office of Navigation Safety and Waterway Services, Short Ran...

  5. 40 CFR 86.001-22 - Approval of application for certification; test fleet selections; determinations of parameters...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... certification; test fleet selections; determinations of parameters subject to adjustment for certification and..., and for 1985 and Later Model Year New Gasoline Fueled, Natural Gas-Fueled, Liquefied Petroleum Gas...; test fleet selections; determinations of parameters subject to adjustment for certification and...

  6. 40 CFR 86.001-22 - Approval of application for certification; test fleet selections; determinations of parameters...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... certification; test fleet selections; determinations of parameters subject to adjustment for certification and..., and for 1985 and Later Model Year New Gasoline Fueled, Natural Gas-Fueled, Liquefied Petroleum Gas...; test fleet selections; determinations of parameters subject to adjustment for certification and...

  7. 47 CFR 87.25 - Filing of applications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... rules. (c) One application may be submitted for the total number of aircraft stations in the fleet (fleet license). (d) One application for aeronautical land station license may be submitted for the total number of stations in the fleet. (e) One application for modification or transfer of control may be...

  8. 47 CFR 87.25 - Filing of applications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... rules. (c) One application may be submitted for the total number of aircraft stations in the fleet (fleet license). (d) One application for aeronautical land station license may be submitted for the total number of stations in the fleet. (e) One application for modification or transfer of control may be...

  9. 47 CFR 87.25 - Filing of applications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... rules. (c) One application may be submitted for the total number of aircraft stations in the fleet (fleet license). (d) One application for aeronautical land station license may be submitted for the total number of stations in the fleet. (e) One application for modification or transfer of control may be...

  10. 47 CFR 87.25 - Filing of applications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... rules. (c) One application may be submitted for the total number of aircraft stations in the fleet (fleet license). (d) One application for aeronautical land station license may be submitted for the total number of stations in the fleet. (e) One application for modification or transfer of control may be...

  11. AVTA Federal Fleet PEV Readiness Data Logging and Characterization Study: Final Report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Schey, Stephen; Francfort, Jim

    2015-06-01

    Collect and evaluate data on federal fleet operations as part of the Advanced Vehicle Testing Activity’s Federal Fleet Vehicle Data Logging and Characterization Study. The Advanced Vehicle Testing Activity study seeks to collect and evaluate data to validate the utilization of advanced plug-in electric vehicle (PEV) transportation. This report summarizes the fleets studied to identify daily operational characteristics of select vehicles and report findings on vehicle and mission characterizations to support the successful introduction of PEVs into the agencies’ fleets. Individual observations of these selected vehicles provide the basis for recommendations related to electric vehicle adoption and whether a batterymore » electric vehicle or plug-in hybrid electric vehicle (collectively referred to as PEVs) can fulfill the mission requirements.« less

  12. Fleet DNA (Presentation)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Walkokwicz, K.; Duran, A.

    2014-06-01

    The Fleet DNA project objectives include capturing and quantifying drive cycle and technology variation for the multitude of medium- and heavy-duty vocations; providing a common data storage warehouse for medium- and heavy-duty vehicle fleet data across DOE activities and laboratories; and integrating existing DOE tools, models, and analyses to provide data-driven decision making capabilities. Fleet DNA advantages include: for Government - providing in-use data for standard drive cycle development, R&D, tech targets, and rule making; for OEMs - real-world usage datasets provide concrete examples of customer use profiles; for fleets - vocational datasets help illustrate how to maximize return onmore » technology investments; for Funding Agencies - ways are revealed to optimize the impact of financial incentive offers; and for researchers -a data source is provided for modeling and simulation.« less

  13. P-8A Poseidon Multi-Mission Maritime Aircraft (P-8A)

    DTIC Science & Technology

    2013-12-01

    NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND...2013 rated the P-8A as operationally effective , operationally suitable, and recommended Fleet introduction. Integrated testing of deficiency...lot through effective negotiations with the prime contractor and through development and implementation of production process improvement

  14. Defense Small Business Innovation Research Program (SBIR) Abstracts of Phase 1 Awards 1983.

    DTIC Science & Technology

    1984-04-06

    STRATEGY, THE INTERPLAY BETWEEN ELECTROMAGNETIC EMISSION CON- TROL AND FLEET OPERATION. THE TECHNICAL APPROACH IS BASED ON AN ANALYSIS OF EMCON...THEM AND A BOTTOM UP APPROACH . THE REQUIREMENTS AND ARCHITECTURAL ASPECTS WILL BE EXPLORED FROM THE MORE ENCOMPASSING PERSPECTIVE OF THE TOTAL...AN AI APPROACH TO INFORMATION FUSION INCLUDING KNOW- LEDGE ORGANIZATION, HYPOTHESIS REPRESENTATIVES, DOMAIN KNOWLEDGE RE- PRESENTATION, HYPOTHESIS

  15. Alternative Fuels Data Center: Propane Mowers Help National Park Cut

    Science.gov Websites

    vehicle fleet will run on alternative fuels by 2014. With the increased number of AFVs, the park is said that the project has had a positive influence on park staff, other NPS units, local municipality national park in Texas to meet the requirements of the Climate Friendly Parks (CFP) program. CFP is one

  16. Analysis of Elements of the Continuous Monitoring Program

    DTIC Science & Technology

    2009-12-01

    reasons for differences in financial reporting between the CMP and BOR and provide COMNAVSURFOR the opportunity to increase financial reporting timeliness...accuracy, and completeness of the surface fleet. A methodology was developed to analyze financial reporting within the cruiser and frigate classes...the different groupings. A Beta Test was run on six ships for two months, which tested the recommended alternatives to financial reporting and

  17. ESTEEM - Encouraging School Transportation Effective Energy Management - Fuel Economy Management Handbook for Directors of Pupil Transportation, School District Administrators, Transportation Department Management.

    ERIC Educational Resources Information Center

    BRI Systems, Inc., Phoenix, AZ.

    This publication is a guide for school districts to reduce pupil transportation costs and save energy. The information presented is based upon: (1) energy saving programs implemented by school districts; (2) government and industry research efforts in fuel economy; (3) the successful experiences of commercial trucking fleets to save fuel; and (4)…

  18. Navy Future Fleet Platform Architecture Study

    DTIC Science & Technology

    2016-07-01

    Aircraft Carriers Source: GAO Report GAO/NSIAD-98-1, Navy Aircraft Carriers: Cost - Effectiveness of Conventionally and Nuclear - Powered Carriers...and Russia. The analysis shows the U.S. Navy has a decisive advantage in terms of striking power from aircraft carriers, surface combatants, and...conventional power , but roughly the same displacement and an emphasis on containing costs now that some of the Nuclear Propulsion Program requirements no

  19. Roles and Functions, Assessment of the Chairman of the Joint Chiefs Of Staff Report

    DTIC Science & Technology

    1993-07-01

    investments . In October 1992, the Director, Defense Test and Evaluation, informed the Chairman of ... in draft form for the past few years, addressed future test investments as opposed to consolidation of test capabilities and a reduced test and...construction program, the improvements in quieting achieved by the Russian submarine fleet, the level of Russian See comment 10. investment in

  20. R2R Eventlogger: Community-wide Recording of Oceanographic Cruise Science Events

    NASA Astrophysics Data System (ADS)

    Maffei, A. R.; Chandler, C. L.; Stolp, L.; Lerner, S.; Avery, J.; Thiel, T.

    2012-12-01

    Methods used by researchers to track science events during a science research cruise - and to note when and where these occur - varies widely. Handwritten notebooks, printed forms, watch-keeper logbooks, data-logging software, and customized software have all been employed. The quality of scientific results is affected by the consistency and care with which such events are recorded and integration of multi-cruise results is hampered because recording methods vary widely from cruise to cruise. The Rolling Deck to Repository (R2R) program has developed an Eventlogger system that will eventually be deployed on most vessels in the academic research fleet. It is based on the open software package called ELOG (http://midas.psi.ch/elog/) originally authored by Stefan Ritt and enhanced by our team. Lessons have been learned in its development and use on several research cruises. We have worked hard to find approaches that encourage cruise participants to use tools like the eventlogger. We examine these lessons and several eventlogger datasets from past cruises. We further describe how the R2R Science Eventlogger works in concert with the other R2R program elements to help coordinate research vessels into a coordinated mobile observing fleet. Making use of data collected on different research cruises is enabled by adopting common ways of describing science events, the science instruments employed, the data collected, etc. The use of controlled vocabularies and the practice of mapping these local vocabularies to accepted oceanographic community vocabularies helps to bind shipboard research events from different cruises into a more cohesive set of fleet-wide events that can be queried and examined in a cross-cruise manner. Examples of the use of the eventlogger during multi-cruise oceanographic research programs along with examples of resultant eventlogger data will be presented. Additionally we will highlight the importance of vocabulary use strategies to the success of the Eventlogger use by the research community. The R2R Science Eventlogger runs on a dedicated "plugable" linux computer installed on each research vessel network. This R2R web server has been designed so it can be extended to support future R2R services. Best practice documents supporting increased consistency for underway instrument data collection, quality assessment of underway instrument data, and other useful capabilities made available on this common shipboard server platform will begin to provide a common set of web-services and science software tools for the "fleet-observatory".; Screenshot of customizable science event entry form that is part of the R2R Science Eventlogger software package. Latitude and Longitude are automatically added at the time the entry is made.

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