46 CFR 160.027-3 - Additional requirements for life floats.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 6 2010-10-01 2010-10-01 false Additional requirements for life floats. 160.027-3..., CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Life Floats for Merchant Vessels § 160.027-3 Additional requirements for life floats. (a) Each life float must have a platform designed...

46 CFR 160.027-3 - Additional requirements for life floats.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 6 2011-10-01 2011-10-01 false Additional requirements for life floats. 160.027-3..., CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Life Floats for Merchant Vessels § 160.027-3 Additional requirements for life floats. (a) Each life float must have a platform designed...

14 CFR 29.757 - Hull and auxiliary float strength.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Hull and auxiliary float strength. 29.757... AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Design and Construction Floats and Hulls § 29.757 Hull and auxiliary float strength. The hull, and auxiliary floats if used, must withstand the...

46 CFR 160.027-3 - Additional requirements for life floats.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 6 2014-10-01 2014-10-01 false Additional requirements for life floats. 160.027-3..., CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Life Floats for Merchant Vessels § 160.027-3 Additional requirements for life floats. (a) Each life float must have a platform designed...

46 CFR 160.027-3 - Additional requirements for life floats.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 6 2013-10-01 2013-10-01 false Additional requirements for life floats. 160.027-3..., CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Life Floats for Merchant Vessels § 160.027-3 Additional requirements for life floats. (a) Each life float must have a platform designed...

46 CFR 160.027-3 - Additional requirements for life floats.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 6 2012-10-01 2012-10-01 false Additional requirements for life floats. 160.027-3..., CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Life Floats for Merchant Vessels § 160.027-3 Additional requirements for life floats. (a) Each life float must have a platform designed...

14 CFR 23.753 - Main float design.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Main float design. 23.753 Section 23.753... STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES Design and Construction Floats and Hulls § 23.753 Main float design. Each seaplane main float must meet the requirements of § 23.521. [Doc...

14 CFR 25.753 - Main float design.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Main float design. 25.753 Section 25.753 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Design and Construction Floats and Hulls § 25.753 Main float design...

Finite element analysis and clinical complications in mandibular implant-overdentures opposing maxillary dentures.

PubMed

Khuder, Tameem; Yunus, Norsiah; Sulaiman, Eshamsul; Dabbagh, Ali

2017-11-01

Denture fracture is a common clinical complication caused by improper material selection, design, or fabrication technique. This study aimed to investigate the effect of two attachment systems on fracture risk of the implant-overdentures (IOD) via finite element analysis (FEA), using the force distributions obtained from patients' occlusal analyses and to compare the obtained results with the clinical complications associated with these attachments. A three-dimensional jaw model comprised of the edentulous bones was constructed. Three types of mandibular prostheses including complete denture (CD) (model LCD), IOD with Locator attachment (model LID-L), and IOD with telescopic attachment (model LID-T), as well as a maxillary CD (model UCD) were assembled. The vertical occlusal forces at anterior and posterior quadrants were obtained from the patients wearing mandibular CDs or IODs. The FEA results were further compared with the mechanical failures of different prostheses observed at patient recalls. In overall, the fracture risk of mandibular prostheses was lower than the maxillary compartments. The UCD opposing LCD underwent higher strains than that opposing LID-L and LID-T, which was mostly concentrated at the anterior mid-palatal polished surface. On the other hand, LID-L showed the lowest strain, followed by LID-T, and LCD. The obtained results were consistent with the clinical complications observed in the patient recalls. Copyright © 2017 Elsevier Ltd. All rights reserved.

The Ω-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function

PubMed Central

Johnson, Troy A.; Holyoak, Todd

2012-01-01

Phosphoenolpyruvate carboxykinase (PEPCK) is an essential metabolic enzyme operating in the gluconeogenesis and glyceroneogenesis pathways. Recent studies have demonstrated that the enzyme contains a mobile active site lid domain that transitions between an open/disorded conformation to a closed/ordered conformation as the enzyme progresses through the catalytic cycle. The understanding of how this mobile domain functions in catalysis is incomplete. Previous studies show that the closure of the lid domain stabilizes the reaction intermediate and protects the reactive intermediate from spurious protonation and thus contributes to the fidelity of the enzyme. In order to more fully investigate the roles of the lid domain in PEPCK function we created three mutations that replaced the 11-residue lid domain with one, two or three glycine residues. Kinetic analysis of the mutant enzymes demonstrates that none of the enzyme constructs exhibit any measurable kinetic activity resulting in a decrease in the catalytic parameters by at least 106. Structural characterization of the mutants in complexes representing the catalytic cycle suggest that the inactivity is due to a role for the lid domain in the formation of the fully closed state of the enzyme that is required for catalytic function. In the absence of the lid domain, the enzyme is unable to achieve the fully closed state and is rendered inactive despite possessing all of the residues and substrates required for catalytic function. This work demonstrates how enzyme catalytic function can be abolished through the alteration of conformational equilibria despite all elements required for chemical conversion of substrates to products remaining intact. PMID:23127136

77 FR 44544 - Safety Zone; Gilmerton Bridge Center Span Float-In, Elizabeth River; Norfolk, Portsmouth, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-30

...-AA00 Safety Zone; Gilmerton Bridge Center Span Float-In, Elizabeth River; Norfolk, Portsmouth, and... withdrawing its proposed rule concerning the Gilmerton Bridge Center Span Float-in and bridge construction of... ``Safety Zone; Gilmerton Bridge Center Span Float-in, Elizabeth River; Norfolk, Portsmouth, and Chesapeake...

Using Tensor Completion Method to Achieving Better Coverage of Traffic State Estimation from Sparse Floating Car Data

PubMed Central

Ran, Bin; Song, Li; Cheng, Yang; Tan, Huachun

2016-01-01

Traffic state estimation from the floating car system is a challenging problem. The low penetration rate and random distribution make available floating car samples usually cover part space and time points of the road networks. To obtain a wide range of traffic state from the floating car system, many methods have been proposed to estimate the traffic state for the uncovered links. However, these methods cannot provide traffic state of the entire road networks. In this paper, the traffic state estimation is transformed to solve a missing data imputation problem, and the tensor completion framework is proposed to estimate missing traffic state. A tensor is constructed to model traffic state in which observed entries are directly derived from floating car system and unobserved traffic states are modeled as missing entries of constructed tensor. The constructed traffic state tensor can represent spatial and temporal correlations of traffic data and encode the multi-way properties of traffic state. The advantage of the proposed approach is that it can fully mine and utilize the multi-dimensional inherent correlations of traffic state. We tested the proposed approach on a well calibrated simulation network. Experimental results demonstrated that the proposed approach yield reliable traffic state estimation from very sparse floating car data, particularly when dealing with the floating car penetration rate is below 1%. PMID:27448326

Using Tensor Completion Method to Achieving Better Coverage of Traffic State Estimation from Sparse Floating Car Data.

PubMed

Ran, Bin; Song, Li; Zhang, Jian; Cheng, Yang; Tan, Huachun

2016-01-01

Traffic state estimation from the floating car system is a challenging problem. The low penetration rate and random distribution make available floating car samples usually cover part space and time points of the road networks. To obtain a wide range of traffic state from the floating car system, many methods have been proposed to estimate the traffic state for the uncovered links. However, these methods cannot provide traffic state of the entire road networks. In this paper, the traffic state estimation is transformed to solve a missing data imputation problem, and the tensor completion framework is proposed to estimate missing traffic state. A tensor is constructed to model traffic state in which observed entries are directly derived from floating car system and unobserved traffic states are modeled as missing entries of constructed tensor. The constructed traffic state tensor can represent spatial and temporal correlations of traffic data and encode the multi-way properties of traffic state. The advantage of the proposed approach is that it can fully mine and utilize the multi-dimensional inherent correlations of traffic state. We tested the proposed approach on a well calibrated simulation network. Experimental results demonstrated that the proposed approach yield reliable traffic state estimation from very sparse floating car data, particularly when dealing with the floating car penetration rate is below 1%.

SoLid Detector Technology

NASA Astrophysics Data System (ADS)

Labare, Mathieu

2017-09-01

SoLid is a reactor anti-neutrino experiment where a novel detector is deployed at a minimum distance of 5.5 m from a nuclear reactor core. The purpose of the experiment is three-fold: to search for neutrino oscillations at a very short baseline; to measure the pure 235U neutrino energy spectrum; and to demonstrate the feasibility of neutrino detectors for reactor monitoring. This report presents the unique features of the SoLid detector technology. The technology has been optimised for a high background environment resulting from low overburden and the vicinity of a nuclear reactor. The versatility of the detector technology is demonstrated with a 288 kg detector prototype which was deployed at the BR2 nuclear reactor in 2015. The data presented includes both reactor on, reactor off and calibration measurements. The measurement results are compared with Monte Carlo simulations. The 1.6t SoLid detector is currently under construction, with an optimised design and upgraded material technology to enhance the detector capabilities. Its deployement on site is planned for the begin of 2017 and offers the prospect to resolve the reactor anomaly within about two years.

On Ceramics.

ERIC Educational Resources Information Center

School Arts, 1982

1982-01-01

Presents four ceramics activities for secondary-level art classes. Included are directions for primitive kiln construction and glaze making. Two ceramics design activities are described in which students make bizarrely-shaped lidded jars, feet, and footwear. (AM)

46 CFR 160.073-1 - Scope.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Float-Free Link or Life Floats and Buoyant Apparatus § 160.073-1 Scope. (a... apparatus painter to a vessel. The float-free link is designed to be broken by the buoyant force of the life...

Top-down solidification of lunar magma ocean

NASA Astrophysics Data System (ADS)

Zhu, D.; Zhang, M.; Xu, Y.

2017-12-01

The early Moon was wholly or mostly molten, known as Lunar Magma Ocean (LMO) [1]. Most models suggest that the solidification of the LMO is bottom-up crystallization, because the liquidus temperature of the LMO increases with pressure more quickly than the adiabatic temperature [2]. In addition, the quenched lid is simply assumed to founder into the LMO [3, 4], because this solid lid is denser than the magma ocean liquids. Therefore, the dominated model for the solidification of the LMO is: olivine and pyroxene crystallized first at the base of the LMO and form the Moon's mantle; after ˜80% of the LMO had solidified, plagioclase began to crystallize and floated from dense silicate melt to the surface to form a global crust of anorthosite [5]. However, as the observational data on lunar meteorites accumulated, the standard model received challenges [6, 7]. Here we propose a new model suggesting the solidification of the LMO is top-down. Our model considers that olivine, pyroxene and plagioclase would crystalize at the mush region between the initially quenched lid and the interior of the LMO at the initial stage. Then the crystallized plagioclase floated and collected at the Moon's surface to form a stable anorthosite-crust; while the crystallized olivine and pyroxene would descend into the LMO and completely remelt away because the LMO interior is super-liquidus [2]. The overall result of our model is that plagioclase existed stably prior to olivine and pyroxene, rather than it crystallized after ˜80% LMO solidification. So, the model here is fundamentally different from previous models [5]. The plagioclase can crystallize from the very beginning to the end of the LMO, that is consistent with the ancient anorthosite age and long anorthosite-crystallization span which is over 200 Myr [6]. Importantly, our model can explain the coexistence of ferroan and magnesian anorthosite [7]. In addition, it is also understandable that the whole lunar mantle is depleted in Eu, Al2O3 and enriched in FeO and TiO2. [1] Wood, J.A. (1986) in Origin of the Moon, 17; [2] Solomatov et al. (2000), in Origin of the Earth and Moon, 323; [3] Spera (1992) GCA 56, 2253; [4] Walker et al. (1980) LPSC, 1196; [5] Snyder et al. (1992) GCA 56, 3809; [6] Pernet-Fisher et al. (2016) Astronomy & Geophysics 57, 1.26; [7] Gross et al. (2014) EPSL 388, 318.

Molecular cloning, expression and immunological properties of LiD1, a protein from the dermonecrotic family of Loxosceles intermedia spider venom.

PubMed

Kalapothakis, Evanguedes; Araujo, Simone Costa; de Castro, Cibele Soares; Mendes, Thais Melo; Gomez, Marcus Vinícius; Mangili, Oldemir C; Gubert, Ida C; Chávez-Olórtegui, Carlos

2002-12-01

The present report describes the identification and molecular characterization of LiD1, a protein expressed in the venom gland of the brown spider Loxosceles intermedia. LiD1 belongs to a family of proteins with dermonecrotic activity and members of this family have been found in spiders from the genus Loxosceles. The necrotic lesions caused by this group of proteins may lead to serious socio-economic problems such as surgical tissue reconstitution and even patient death. LiD1 was cloned using a cDNA library constructed from the venom gland of L. intermedia and antibodies against proteins with dermonecrotic activity isolated from the crude venom of this spider. The amino acid sequence deduced from the cDNA revealed a mature protein of approximately 31 kDa, with a pI of 7.37. The cDNA also revealed the existence of a signal peptide, a propeptide and also an untranslated 3' region with 218 nucleotides. LiD1 was expressed as a protein fused with beta-galactoside protein using the vector pBK-CMV, resulting in the recombinant protein recLiD1 with important immunological properties. recLiD1 was strongly recognised by anti-dermonecrotic antibodies and was also able to generate reactive antibodies against native dermonecrotic proteins isolated from the venom of L. intermedia.

NPSNET: Dynamic Terrain and Cultured Feature Depiction

DTIC Science & Technology

1992-09-01

defaults. bridge(terrain *ptr, vertex pos, bridge mattype bmat ); This constructor takes only the pointer to the underlying terrain, a placement, and a...material to use for construction. bridge(terrain *ptr, vertex pos, bridge-mattype bmat , float dir); This constructor takes a terrain pointer, a...placement position, a material to use, and a direction to run. bridge(terrain *ptr, vertex pos, bridge-mattype bmat , float dir, float width, float height

The Goals and Status of SoLid Experiment

NASA Astrophysics Data System (ADS)

Park, Jaewon

2016-09-01

SoLid is a short baseline sterile neutrino oscillation search experiment using the BR2 compact core reactor in Belgium. Ruling out or confirming sterile neutrino is one of main interests in the neutrino physics field. Highly segmented scintillator cube detector with 6LiF:ZnS(Ag) neutron screen provides high purity neutron tagging by pulse shape discrimination (PSD), and capture position identification. These capabilities from this novel detector are critical to isolate neutrino interactions in a high background environment. The prototype detector (SM1) provides important feedback for validating the performance of the detector design. Recent results from SM1 will be presented. Construction of the SoLid Phase-1 detector is underway. The three-ton detector with three years running will allow us to reach the sterile neutrino exclusion limit of sin2 2 θ < 0 . 03 at Δm2 2eV2 at the 99% confidence level.

77 FR 35900 - Safety Zone; Gilmerton Bridge Center Span Float-in, Elizabeth River; Norfolk, Portsmouth, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-15

...-AA00 Safety Zone; Gilmerton Bridge Center Span Float-in, Elizabeth River; Norfolk, Portsmouth, and... navigable waters during the Gilmerton Bridge Center Span Float- in and bridge construction of span placement... the existing bascule spans from the Gilmerton Bridge, transport the new center span from the Eastern...

Optimal capacity design of LID facility for conserving natural water cycle and its sensitivity analysis

NASA Astrophysics Data System (ADS)

Lee, O.; Choi, J.; Lee, J.; Kim, S.

2017-12-01

Since the 20th century, urbanization has resulted in increased impermeable land surface and reduced infiltration capacity in catchment scale. Especially, when agriculture area or forest area would be developed into urban area, it can cause more runoff in the same climate condition. Such urbanization causes problems such as changes in hydrological cycle and ecosystem disturbance. Various methods have been proposed worldwide to reduce the impact of such urbanization. Among the various strategies, the low-impact development is a development strategy that aims to return to pre-development state by minimizing the change of the hydrological cycle due to urbanization. In this strategy, the infiltration and/or surface storage of stormwater runoff can be increased through the installation of various facilities. In this study, a facility capacity design strategy is proposed to return into the natural water cycle through the installation of various LID facilities. This is accomplished by determining the optimal LID facility design capacity through which flow duration curves remain the same before and after urban development. For this purpose, EPA-SWMM is constructed with a part of Busan Metropolitan City Noksan Industrial Complex as a virtual processing area. Under the various land-use scenarios, the optimum design capacity of various LID facilities capable of retaining the flow duration curve before and after development is determined. In addition, the sensitivity of the optimal design capacity of LID facilities is analyzed according to the design specifications of various LID facilities, the local rainfall characteristics, and the size of the treatment area. Acknowledgement This research was supported by a grant (2016000200002) from Public Welfare Technology Development Program funded by Ministry of Environment of Korean government.

40 CFR 60.693-2 - Alternative standards for oil-water separators.

Code of Federal Regulations, 2010 CFR

2010-07-01

...-water separators. (a) An owner or operator may elect to construct and operate a floating roof on an oil... requirements of this subpart which meets the following specifications. (1) Each floating roof shall be equipped... the liquid between the wall of the separator and the floating roof. A mechanical shoe seal means a...

77 FR 73541 - Safety Zone: Gilmerton Bridge Center Span Float-in, Elizabeth River; Norfolk, Portsmouth, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-11

...-AA00 Safety Zone: Gilmerton Bridge Center Span Float-in, Elizabeth River; Norfolk, Portsmouth, and... Gilmerton Bridge Center Span Float- in and bridge construction of span placement. This action is intended to... rulemaking (NPRM) proposing a safety zone in the Gilmerton Bridge Area (77 FR 43557) on September 5-9, 2012...

Tiny Bubbles.

ERIC Educational Resources Information Center

Kim, Hy

1985-01-01

A simple oxygen-collecting device (easily constructed from glass jars and a lid) can show bubbles released by water plants during photosynthesis. Suggestions are given for: (1) testing the collected gas; (2) using various carbon dioxide sources; and (3) measuring respiration. (DH)

A Simplified Design with a Toothed Belt and Non-Circular Pulleys to Separate Parts from a Magazine File

NASA Astrophysics Data System (ADS)

Hanke, U.; Modler, K.-H.; Neumann, R.; Fischer, C.

The objective of this paper is to simplify a very complex guidance mechanism, currently used for lid separating issues in a packaging-machine. The task of this machine is to pick up a lid from a magazine file, rotate it around 180° and place it on tins. The developed mechanism works successfully but with a very complex construction. It consists of a planetary cam mechanism, combined with a toothed gear (with a constant transmission ratio) and a guiding mechanism with a toothed belt and circular pulleys. Such complex constructions are very common in industrial solutions. The idea of the authors is to show a much simpler design in solving the same problem. They developed a guidance mechanism realizing the same function, consisting only of a toothed belt with non-circular pulleys. The used parts are common trade articles.

Integral stormwater management master plan and design in an ecological community.

PubMed

Che, Wu; Zhao, Yang; Yang, Zheng; Li, Junqi; Shi, Man

2014-09-01

Urban stormwater runoff nearly discharges directly into bodies of water through gray infrastructure in China, such as sewers, impermeable ditches, and pump stations. As urban flooding, water shortage, and other environment problems become serious, integrated water environment management is becoming increasingly complex and challenging. At more than 200ha, the Oriental Sun City community is a large retirement community located in the eastern side of Beijing. During the beginning of its construction, the project faced a series of serious water environment crises such as eutrophication, flood risk, water shortage, and high maintenance costs. To address these issues, an integral stormwater management master plan was developed based on the concept of low impact development (LID). A large number of LID and green stormwater infrastructure (GSI) approaches were designed and applied in the community to replace traditional stormwater drainage systems completely. These approaches mainly included bioretention (which captured nearly 85th percentile volume of the annual runoff in the site, nearly 5.4×10(5)m(3) annually), swales (which functioned as a substitute for traditional stormwater pipes), waterscapes, and stormwater wetlands. Finally, a stormwater system plan was proposed by integrating with the gray water system, landscape planning, an architectural master plan, and related consultations that supported the entire construction period. After more than 10 years of planning, designing, construction, and operation, Oriental Sun City has become one of the earliest modern large-scale LID communities in China. Moreover, the project not only addressed the crisis efficiently and effectively, but also yielded economic and ecological benefits. Copyright © 2014. Published by Elsevier B.V.

Removal of nutrients and veterinary antibiotics from swine wastewater by a constructed macrophyte floating bed system.

PubMed

Xian, Qiming; Hu, Lixia; Chen, Hancheng; Chang, Zhizhou; Zou, Huixian

2010-12-01

The potential of three varieties of Italian ryegrass (Lolium multiflorum Lam.), Dryan, Tachimasari and Waseyutaka, to improve the water quality of swine wastewater was evaluated using a constructed macrophyte floating bed system. With respect to reductions in levels of nutrients, chemical oxygen demand (COD), and sulfonamide antimicrobials (SAs, including sulfadiazine, sulfamethazine, and sulfamethoxazole), Dryan performed better than Tachimasari and Waseyutaka. For Dryan, total N was reduced by 84.0%, total P by 90.4%, COD by 83.4% and sulfonamide antimicrobials by 91.8-99.5%. Similar results were observed for Tachimasari and Waseyutaka. The results indicated that the treatment of swine wastewater using the constructed macrophyte floating bed system was effective in the removal of nutrients and veterinary antibiotics. Copyright © 2010 Elsevier Ltd. All rights reserved.

Light yield and energy resolution studies for SoLid phase 1

NASA Astrophysics Data System (ADS)

Boursette, Delphine; SoLid Collaboration

2017-09-01

The SoLid experiment is searching for sterile neutrinos at a nuclear research reactor. It looks for inverse beta decays (producing a positron and a neutron in delayed coincidence) with a very segmented detector made of thousands of scintillating cubes. SoLid has a very innovative hybrid technology with two different scintillators which have different light emissions: polyvynil-toluene cubes (PVT) to detect the positrons and 6LiF:ZnS sheets on two faces of each PVT cube to detect the neutrons. It allows us to do an efficient pulse shape analysis to identify the signals from neutrons and positrons. The 288 kg detector prototype (SM1) took data in 2015. It demonstrated the detection principle and background rejection efficiency. The construction of SoLid phase I (˜ 1.5 t) has now started. To improve the energy resolution of SoLid phase I, we have tried to increase the light yield studying separately the two scintillators: PVT and ZnS. A test bench has been built to fully characterize and improve the neutron detection with the ZnS using an AmBe source. To study the positron light yield on the PVT, we have built another test bench with a 207Bi source. We have improved the design of the cubes, their wrapping or the type and the configuration of the fibers. We managed to increase the PVT light yield by about 66 % and improve the resolution of the positron energy on the test bench from 21 % to 16 % at 1 MeV.

Capture of free-floating planets by planetary systems

NASA Astrophysics Data System (ADS)

Goulinski, Nadav; Ribak, Erez N.

2018-01-01

Evidence of exoplanets with orbits that are misaligned with the spin of the host star may suggest that not all bound planets were born in the protoplanetary disc of their current planetary system. Observations have shown that free-floating Jupiter-mass objects can exceed the number of stars in our Galaxy, implying that capture scenarios may not be so rare. To address this issue, we construct a three-dimensional simulation of a three-body scattering between a free-floating planet and a star accompanied by a Jupiter-mass bound planet. We distinguish between three different possible scattering outcomes, where the free-floating planet may get weakly captured after the brief interaction with the binary, remain unbound or 'kick out' the bound planet and replace it. The simulation was performed for different masses of the free-floating planets and stars, as well as different impact parameters, inclination angles and approach velocities. The outcome statistics are used to construct an analytical approximation of the cross-section for capturing a free-floating planet by fitting their dependence on the tested variables. The analytically approximated cross-section is used to predict the capture rate for these kinds of objects, and to estimate that about 1 per cent of all stars are expected to experience a temporary capture of a free-floating planet during their lifetime. Finally, we propose additional physical processes that may increase the capture statistics and whose contribution should be considered in future simulations in order to determine the fate of the temporarily captured planets.

A Comparison of Runoff Quantity and Quality from Two Small Basins Undergoing Implementation of Conventional and Low-Impact-Development (LID) Strategies: Cross Plains, Wisconsin, Water Years 1999-2005

USGS Publications Warehouse

Selbig, William R.; Bannerman, Roger T.

2008-01-01

Environmental managers are often faced with the task of designing strategies to accommodate development while minimizing adverse environmental impacts. Low-impact development (LID) is one such strategy that attempts to mitigate environmental degradation commonly associated with impervious surfaces. The U.S. Geological Survey, in cooperation with the Wisconsin Department of Natural Resources, studied two residential basins in Cross Plains, Wis., during water years 1999?2005. A paired-basin study design was used to compare runoff quantity and quality from the two basins, one of which was developed in a conventional way and the other was developed with LID. The conventional-developed basin (herein called ?conventional basin?) consisted of curb and gutter, 40-foot street widths, and a fully connected stormwater-conveyance system. The LID basin consisted of grassed swales, reduced impervious area (32-foot street widths), street inlets draining to grass swales, a detention pond, and an infiltration basin. Data collected in the LID basin represented predevelopment through near-complete build-out conditions. Smaller, more frequent precipitation events that produced stormwater discharge from the conventional basin were retained in the LID basin. Only six events with precipitation depths less than or equal to 0.4 inch produced measurable discharge from the LID basin. Of these six events, five occurred during winter months when underlying soils are commonly frozen, and one was likely a result of saturated soil from a preceding storm. In the conventional basin, the number of discharge events, using the same threshold of precipitation depth, was 180, with nearly one-half of those resulting from precipitation depths less than 0.2 inch. Precipitation events capable of producing appreciable discharge in the LID basin were typically those of high intensity or precipitation depth or those that occurred after soils were already saturated. Total annual discharge volume measured from the conventional basin ranged from 1.3 to 9.2 times that from the LID basin. Development of the LID basin did not appreciably alter the hydrologic response to precipitation characterized during predevelopment conditions. Ninety-five percent or more of precipitation in the LID basin was retained during each year of construction from predevelopment through near-complete build-out, surpassing the 90-percent benchmark established for new development by the Wisconsin Department of Natural Resources. The amount of precipitation retained in the conventional basin did not exceed 94 percent and fell below the 90-percent standard 2 of the 6 years monitored. Much of the runoff in the LID basin was retained by an infiltration basin, the largest control structure used to mitigate storm-runoff quantity and quality. The infiltration basin also was the last best-management practice (BMP) used to treat runoff before it left the LID basin as discharge. From May 25, 2002, to September 30, 2005, only 24 of 155 precipitation events exceeded the retention/ infiltrative capacity of the infiltration basin. The overall reduction in runoff volume from these few events was 51 percent. The effectiveness of the infiltration basin decreased as precipitation intensities exceeded 0.5 inch per hour. Annual loads were estimated to characterize the overall effectiveness of low-impact design practices for mitigating delivery of total solids, total suspended solids, and total phosphorus. Annual loads of these three constituents were greater in the LID basin than in the conventional basin in 2000 and 2004. Seventy percent or more of all constituent annual loads were associated with two discharge events in 2000, and a single discharge event produced 50 percent or more of constituent annual loads in 2004. Each of these discharge events was associated with considerable precipitation depths and (or) intensities, ranging from 4.89 to 6.21 inches and from 1.13 to 1.2 inches per hour, respectively

46 CFR 160.073-5 - Certification.

Code of Federal Regulations, 2011 CFR

2011-10-01

... COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Float-Free Link or Life Floats and Buoyant Apparatus § 160.073-5... COMDTINST M16714.3 (Series), “Equipment Lists,” the manufacturer must send a letter requesting the listing...

Sustainable urban stormwater management in the tropics: An evaluation of Singapore's ABC Waters Program

NASA Astrophysics Data System (ADS)

Lim, H. S.; Lu, X. X.

2016-07-01

The Active Beautiful Clean (ABC) Waters Program was implemented in 2006 as part of Singapore's stormwater management strategy and reflects the country's move towards Water Sensitive Urbanism through the adoption of Low-Impact Development (LID) ideology and practices. It is the first holistic and comprehensive LID program in the tropics and holds promise for extension to other tropical cities. This paper presents a comprehensive summary of the goals, LID practices (ABC design features) and design considerations as well as results of several monitored sites, including a constructed wetland, two rain gardens, green roofs and three canal restoration projects. We evaluate the ABC Waters Program based on these initial results and consider the challenges, issues and the research needs for it to meet its hydrological and water quality remediation goals. So far, the ABC design features evaluated perform well in removing particulates. Performance in nutrient removal is poor. With over 60 projects completed within 10 years, post-project monitoring and evaluation is necessary and complements on-going laboratory and modelling research projects conducted by local academic institutions.

14 CFR 29.755 - Hull buoyancy.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Hull buoyancy. 29.755 Section 29.755... STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Design and Construction Floats and Hulls § 29.755 Hull buoyancy. Water-based and amphibian rotorcraft. The hull and auxiliary floats, if used, must have enough...

The VolturnUS 1:8 Floating Wind Turbine: Design, Construction, Deployment, Testing, Retrieval, and Inspection of the First Grid-Connected Offshore Wind Turbine in US

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dagher, Habib; Viselli, Anthony; Goupee, Andrew

Volume II of the Final Report for the DeepCwind Consortium National Research Program funded by US Department of Energy Award Number: DE-EE0003278.001 summarizes the design, construction, deployment, testing, numerical model validation, retrieval, and post-deployment inspection of the VolturnUS 1:8-scale floating wind turbine prototype deployed off Castine, Maine on June 2nd, 2013. The 1:8 scale VolturnUS design served as a de-risking exercise for a commercial multi-MW VolturnUS design. The American Bureau of Shipping Guide for Building and Classing Floating Offshore Wind Turbine Installations was used to design the prototype. The same analysis methods, design methods, construction techniques, deployment methods, mooring, andmore » anchoring planned for full-scale were used. A commercial 20kW grid-connected turbine was used and was the first offshore wind turbine in the US.« less

Control Scheme of River-lake System from the View of Ecological Sponge Basin aiming at Sponge City Construction

NASA Astrophysics Data System (ADS)

Ding, X.; Liu, J.; Yang, Z.

2017-12-01

China is in the rapid advance of urbanization, and is promoting the Sponge City Construction (SCC) with the characteristics of natural accumulation, natural infiltration and natural purification. The Chinese government selected 16 and 14 cities as pilot cities in 2015 and 2016 respectively to carry out SCC taking Low Impact Development (LID) as the concept. However, in 2015 and 2016, water-logging occurred in 10 cities and 9 cities respectively during the pilot cities. Therefore, relying solely on LID can not solve the problem of urban flood and waterlogging. Except for a series of LID measures during the process of SCC, corresponding control scheme of river-lake system should be established to realize water-related targets. From the view of ecological sponge basin, this study presents the general idea of SCC both in and out of the unban built-up area and the corresponding control scheme of river-lake system: for the regions outside the built-up area, the main aim of SCC is to carry out the top-level design of urban flood control and waterlogging, establish the water security system outside the city for solving the problems including flood control, water resources, water environment and water ecology; for the built-up area, the main aim of SCC is to construct different kinds of urban sponge according to local conditions and develop multi-scale drainage system responding to different intensities of rainfall taking the river-lake system as the core. Taking Fenghuang County of Hunan Province as an example for the application research, the results indicate that, after the implementation of the control scheme of river-lake system: 1) together with other SCC measures including LID, the control rate of total annual runoff in Fenghuang County is expected to be 82.9% which meets the target requirement of 80%; 2) flood control and drainage standards in Fenghuang County can be increased from the current 10-year return to 20-year return; 3) urban and rural water supply guarantee rate is expected to be 98% which meets the target requirement of 95%. Therefore, the control scheme of urban river-lake system in the county is technically feasible, and can effectively solve the problems including flood control, water resources shortage and ecological water demand in the county, thus may provide strong support and guarantee for SCC.

95. Photocopied August 1978. CRIBS BEING FLOATED INTO PLACE FOR ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

95. Photocopied August 1978. CRIBS BEING FLOATED INTO PLACE FOR THE CONSTRUCTION OF THE SECOND SET (NOS. 13-16) OF COMPENSATING GATES. NOTE THE ORIGINAL FOUR GATES IN THE BACKGROUND, MAY 14, 1915. (587) - Michigan Lake Superior Power Company, Portage Street, Sault Ste. Marie, Chippewa County, MI

77 FR 47876 - Intent To Prepare Environmental Impact Statements: Potential Commercial Wind Lease Issuance and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-10

... Statoil NA's proposed project, Hywind Maine, would consist of four 3-megawatt (MW) floating wind turbine... request by Statoil NA, is to construct a full-scale, deepwater floating wind turbine facility that... Prepare Environmental Impact Statements: Potential Commercial Wind Lease Issuance and Decision Regarding...

33 CFR 159.125 - Visible floating solids: Type I devices.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Visible floating solids: Type I devices. 159.125 Section 159.125 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION MARINE SANITATION DEVICES Design, Construction, and Testing § 159.125...

32 CFR 736.5 - Disposition of real and personal property under special statutory authority.

Code of Federal Regulations, 2011 CFR

2011-07-01

... of Naval Operations, applications for boats to the Naval Sea Systems Command, and applications for barges, floating drydocks, and other floating construction equipment to the Naval Facilities Engineering... Disposition Manual. (g) Disposition of equipment for research. Under the act of September 6, 1958 (72 Stat...

[Preliminary study on transdermal characteristics and sunface anesthetic effects of lidocaine hydrochloride loaded trans-activator of transcription peptide conjugated nano-niosome in animals].

PubMed

Wang, Yue; Zhang, Lianyun; Li, Changyi; Wang, Hanjie; Li, Qin

2015-07-01

To prepare a new dental topical anesthetics, lidocaine hydrochloride loaded trans-activator of transcription peptide conjugated nano-niosome (LID-TAT-N), and to evaluate its transdermal properties and topical anesthesia effects. LID-TAT-N was prepared using reverse-phase evaporation method, and lidocaine loaded conventional liposome (LID-CL) was prepared in the same manner as positive control. The diameter, ζ potential and encapsulation efficiency of LID-TAT-N and LID-CL were measured. The skin permeation of LID-TAT-N was examined, and compared with LID-CL and lidocaine injection (LID-IJ, as negative control), using a Franz diffusion cell mounted with depilated mouse skin in vitro for 12 hours. Each experiment was repeated six times. The anesthetic effect of the new topical anesthetic was investigated on the cornea of rabbits. The mean diameter of LID-TAT-N was smaller than that of LID-CL [(152.7 ± 10.6) nm vs. (259.5 ± 15.5) nm, P < 0.01]. The 12 h cumulative permeation amount was significantly higher in LID-TAT-N group [(1 340.0 ± 97.5) µg · cm(-2)] than those of LID-CL and LID-IJ groups [(1 060.6 ± 80.2), (282.6 ± 65.1) µg · cm(-2), respectively, P < 0.05]. Rabbit corneal reflex results showed that LID-TAT-N had anesthetic effect and the duration of analgesia [(24.8 ± 2.8) min] was also longer than that of LID-IJ [(14.5 ± 2.3) min, P < 0.05]. LID-TAT-N had good transdermal ability, and the advanced skin penetration feature can improve its tropical anesthetic effect.

Analysis of Alternative (Low Impact) Development on a Theoretical Residential Development in North Central Florida

NASA Astrophysics Data System (ADS)

Wise, W. R.

2001-05-01

Research currently in progress will evaluate land development options on a 161 +/- HA site in North Central Florida lying within a 292+/- HA watershed that contributes to Bullfrog Creek in the Camp Blanding Wildlife Management Area. The research analyzes aspects of an emerging storm-water management philosophy, called low-impact development (LID) by Prince Georges County, Maryland. LID seeks to preserve site hydrology by reducing the area of disturbance on the site, preserving natural drainage features on the site and by utilizing BMPs that promote infiltration and slower transport of runoff. This research investigates the benefits and problems associated with this design philosophy, particularly in Florida. Two scenarios will be investigated: Low density residential and Medium density residential. Within each scenario the hydrologic response of the site under conventional and LID will be explored. Furthermore, the impact of using cluster developments in LIDs will be investigated. Parameters to be measured include: peak flow, runoff volume, pollutant load generated/removed by BMPs, peak-flow timing and base flow. HEC-HMS will be used for hydrologic modeling (soil moisture accounting module). Pollutant loads generated and removed will be based on published data for land use and BMPs. An economic analysis, based on the estimated construction costs of conventional and LID, will also be done. Further sensitivity analyses will be conducted on the effect that various watershed conditions have on the hydrologic response of the site developed as a LID. This research will provide insight to several questions. In the most general sense it will indicate whether this emerging design philosophy, much of which was developed in other regions of the country, is beneficial to Florida watersheds "as it is" and what, if any, alterations should be considered. Secondly, this research will show the impact of development with different site-planning options, for example cluster development versus deed restrictions on lots. Thirdly, the research will give insight to the applicability of this land-development approach under different allowable residential densities. Lastly, the effect of different physical characteristics on the watershed can be explored.

14 CFR 27.755 - Hulls.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Hulls. 27.755 Section 27.755 Aeronautics... STANDARDS: NORMAL CATEGORY ROTORCRAFT Design and Construction Floats and Hulls § 27.755 Hulls. For each rotorcraft, with a hull and auxiliary floats, that is to be approved for both taking off from and landing on...

Monolithic LTCC seal frame and lid

DOEpatents

Krueger, Daniel S.; Peterson, Kenneth A.; Stockdale, Dave; Duncan, James Brent; Riggs, Bristen

2016-06-21

A method for forming a monolithic seal frame and lid for use with a substrate and electronic circuitry comprises the steps of forming a mandrel from a ceramic and glass based material, forming a seal frame and lid block from a ceramic and glass based material, creating a seal frame and lid by forming a compartment and a plurality of sidewalls in the seal frame and lid block, placing the seal frame and lid on the mandrel such that the mandrel fits within the compartment, and cofiring the seal frame and lid block.

Inkjet-printed selective microfluidic biosensor using CNTs functionalized by cytochrome P450 enzyme

NASA Astrophysics Data System (ADS)

Krivec, Matic; Leitner, Raimund; Überall, Florian; Hochleitner, Johannes

2017-05-01

An additive manufacturing concept, consisting of 3D photopolymer printing and Ag nanoparticle printing, was investigated for the construction of a microfluidic biosensor based on immobilized cytochrome P450 enzyme. An acylate-type microfluidic chamber composed of two parts, i.e. chamber-housing and chamber-lid was printed with a polyjet 3D printer. A 3-electrode sensor structure was inkjet-printed on the lid using a combination of Ag and graphene printing. The working electrode was covered with carbon nanotubes by drop-casting and immobilized with cytochrome P450 2D6 enzyme. The microfluidic sensor shows a significant response to a test xenobiotic, i.e. dextromethorphan; the cyclic voltammetrical measurements show a corresponding oxidation peak at 0.4 V with around 5 μM detection limit.

Development of shashlik electromagnetic calorimeter prototype for SoLID

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shen, C.; Wang, Y.; Xiao, D.

A shashlik electromagnetic calorimeter will be produced in Hall A of Jefferson Laboratory for Solenoidal large Intensity Device (SoLID) to measure the energy deposition of electrons and hadrons, and to provide particle identification after the energy of the accelerator was upgraded to 12 GeV. Tsinghua University is the member of Hall A collaboration in charge of development and production of the large shashlik electromagnetic calorimeter of SoLID. One module of that calorimeter is composed by 194 layers. Each layer consists of a 1.5 mm thick plastic scintillator put on top of a 0.5 mm thick lead plate. Scintillation light ismore » read out by wave-length shifter fibers penetrating through the calorimeter modules longitudinally along the direction of flight of the impact particle. This paper describes the design and construction of that module, as well as a few optimization studies meant to improve its performance. A detailed Geant4 simulation also shows that an energy resolution of 5%/√ E (GeV) and a good containment for electromagnetic showers can be achieved, as well as some basic electron identification. In conclusion, a prototype of that module will be tested soon with an electron beam at JLab.« less

Development of shashlik electromagnetic calorimeter prototype for SoLID

DOE PAGES

Shen, C.; Wang, Y.; Xiao, D.; ...

2017-03-07

A shashlik electromagnetic calorimeter will be produced in Hall A of Jefferson Laboratory for Solenoidal large Intensity Device (SoLID) to measure the energy deposition of electrons and hadrons, and to provide particle identification after the energy of the accelerator was upgraded to 12 GeV. Tsinghua University is the member of Hall A collaboration in charge of development and production of the large shashlik electromagnetic calorimeter of SoLID. One module of that calorimeter is composed by 194 layers. Each layer consists of a 1.5 mm thick plastic scintillator put on top of a 0.5 mm thick lead plate. Scintillation light ismore » read out by wave-length shifter fibers penetrating through the calorimeter modules longitudinally along the direction of flight of the impact particle. This paper describes the design and construction of that module, as well as a few optimization studies meant to improve its performance. A detailed Geant4 simulation also shows that an energy resolution of 5%/√ E (GeV) and a good containment for electromagnetic showers can be achieved, as well as some basic electron identification. In conclusion, a prototype of that module will be tested soon with an electron beam at JLab.« less

Overview of LIDS Docking and Berthing System Seals

NASA Technical Reports Server (NTRS)

Daniels, Christopher C.; Dunlap, Patrick H., Jr.; deGroh, Henry C., III; Steinetz, Bruce M.; Oswald, Jay J.; Smith, Ian

2007-01-01

This viewgraph presentation describes the Low Impact Docking System (LIDS) docking and berthing system seals. The contents include: 1) Description of the Application: Low Impact Docking System (LIDS); 2) LIDS Seal Locations: Vehicle Undocked (Hatch Closed); 3) LIDS Seal Locations: Mechanical Pass Thru; 4) LIDS Seal Locations: Electrical and Pyro Connectors; 5) LIDS Seal Locations: Vehicle Docked (Hatches Open); 6) LIDS Seal Locations: Main Interface Seal; 7) Main Interface Seal Challenges and Specifications; 8) Approach; 9) Seal Concepts Under Development/Evaluation; 10) Elastomer Material Evaluations; 11) Evaluation of Relevant Seal Properties; 12) Medium-Scale (12") Gask-O-Seal Compression Tests; 13) Medium-Scale Compression Results; 14) Adhesion Forces of Elliptical Top Gask-o-seals; 15) Medium-Scale Seals; 16) Medium-Scale Leakage Results: Effect of Configuration; 17) Full Scale LIDS Seal Test Rig Development; 18) Materials International Space Station Experiment (MISSE 6A and 6B); and 19) Schedule.

Selection of floating-point or fixed-point for adaptive noise canceller in somatosensory evoked potential measurement.

PubMed

Shen, Chongfei; Liu, Hongtao; Xie, Xb; Luk, Keith Dk; Hu, Yong

2007-01-01

Adaptive noise canceller (ANC) has been used to improve signal to noise ratio (SNR) of somsatosensory evoked potential (SEP). In order to efficiently apply the ANC in hardware system, fixed-point algorithm based ANC can achieve fast, cost-efficient construction, and low-power consumption in FPGA design. However, it is still questionable whether the SNR improvement performance by fixed-point algorithm is as good as that by floating-point algorithm. This study is to compare the outputs of ANC by floating-point and fixed-point algorithm ANC when it was applied to SEP signals. The selection of step-size parameter (micro) was found different in fixed-point algorithm from floating-point algorithm. In this simulation study, the outputs of fixed-point ANC showed higher distortion from real SEP signals than that of floating-point ANC. However, the difference would be decreased with increasing micro value. In the optimal selection of micro, fixed-point ANC can get as good results as floating-point algorithm.

Validity Assessment of 5 Day Repeated Forced-Swim Stress to Model Human Depression in Young-Adult C57BL/6J and BALB/cJ Mice

PubMed Central

Zheng, Jia; Goodyear, Laurie J.

2016-01-01

The development of animal models with construct, face, and predictive validity to accurately model human depression has been a major challenge. One proposed rodent model is the 5 d repeated forced swim stress (5d-RFSS) paradigm, which progressively increases floating during individual swim sessions. The onset and persistence of this floating behavior has been anthropomorphically characterized as a measure of depression. This interpretation has been under debate because a progressive increase in floating over time may reflect an adaptive learned behavioral response promoting survival, and not depression (Molendijk and de Kloet, 2015). To assess construct and face validity, we applied 5d-RFSS to C57BL/6J and BALB/cJ mice, two mouse strains commonly used in neuropsychiatric research, and measured a combination of emotional, homeostatic, and psychomotor symptoms indicative of a depressive-like state. We also compared the efficacy of 5d-RFSS and chronic social defeat stress (CSDS), a validated depression model, to induce a depressive-like state in C57BL/6J mice. In both strains, 5d-RFSS progressively increased floating behavior that persisted for at least 4 weeks. 5d-RFSS did not alter sucrose preference, body weight, appetite, locomotor activity, anxiety-like behavior, or immobility behavior during a tail-suspension test compared with nonstressed controls. In contrast, CSDS altered several of these parameters, suggesting a depressive-like state. Finally, predictive validity was assessed using voluntary wheel running (VWR), a known antidepressant intervention. Four weeks of VWR after 5d-RFSS normalized floating behavior toward nonstressed levels. These observations suggest that 5d-RFSS has no construct or face validity but might have predictive validity to model human depression. PMID:28058270

Validity Assessment of 5 Day Repeated Forced-Swim Stress to Model Human Depression in Young-Adult C57BL/6J and BALB/cJ Mice.

PubMed

Mul, Joram D; Zheng, Jia; Goodyear, Laurie J

2016-01-01

The development of animal models with construct, face, and predictive validity to accurately model human depression has been a major challenge. One proposed rodent model is the 5 d repeated forced swim stress (5d-RFSS) paradigm, which progressively increases floating during individual swim sessions. The onset and persistence of this floating behavior has been anthropomorphically characterized as a measure of depression. This interpretation has been under debate because a progressive increase in floating over time may reflect an adaptive learned behavioral response promoting survival, and not depression (Molendijk and de Kloet, 2015). To assess construct and face validity, we applied 5d-RFSS to C57BL/6J and BALB/cJ mice, two mouse strains commonly used in neuropsychiatric research, and measured a combination of emotional, homeostatic, and psychomotor symptoms indicative of a depressive-like state. We also compared the efficacy of 5d-RFSS and chronic social defeat stress (CSDS), a validated depression model, to induce a depressive-like state in C57BL/6J mice. In both strains, 5d-RFSS progressively increased floating behavior that persisted for at least 4 weeks. 5d-RFSS did not alter sucrose preference, body weight, appetite, locomotor activity, anxiety-like behavior, or immobility behavior during a tail-suspension test compared with nonstressed controls. In contrast, CSDS altered several of these parameters, suggesting a depressive-like state. Finally, predictive validity was assessed using voluntary wheel running (VWR), a known antidepressant intervention. Four weeks of VWR after 5d-RFSS normalized floating behavior toward nonstressed levels. These observations suggest that 5d-RFSS has no construct or face validity but might have predictive validity to model human depression.

Lid dynamics of porcine pancreatic lipase in non-aqueous solvents.

PubMed

Haque, Neshatul; Prabhu, N Prakash

2016-10-01

Understanding the dynamics of enzymes in organic solvents has wider implications on their industrial applications. Pancreatic lipases, which show activity in their lid open-state, demonstrate enhanced activity in organic solvents at higher temperatures. However, the lid dynamics of pancreatic lipases in non-aqueous environment is yet to be clearly understood. Dynamics of porcine pancreatic lipase (PPL) in open and closed conformations was followed in ethanol, toluene, and octanol using molecular simulation methods. In silico double mutant D250V and E254L of PPL (PPLmut-Cl) was created and its lid opening dynamics in water and in octanol was analyzed. PPL showed increase in solvent accessible surface area and decrease in packing density as the polarity of the surrounded solvent decreased. Breaking the interactions between D250-Y115, and D250-E254 in PPLmut-Cl directed the lid to attain open-state conformation. Major energy barriers during the lid movement in water and in octanol were identified. Also, the trajectories of lid movement were found to be different in these solvents. Only the double mutant at higher temperature showed lid opening movement suggesting the essential role of the three residues in holding the lid in closed conformation. The lid opening dynamics was faster in octanol than water suggesting that non-polar solvents favor open conformation of the lid. This study identifies important interactions between the lid and the residues in domain 1 which possibly keeps the lid in closed conformation. Also, it explains the rearrangements of residue-residue interactions during lid opening movement in water and in octanol. Copyright © 2016 Elsevier B.V. All rights reserved.

Lower lid retraction in thyroid orbitopathy: lamellar shortening or proptosis?

PubMed

Rajabi, Mohammad Taher; Jafari, Hajar; Mazloumi, Mehdi; Tabatabaie, Syed Ziaeddin; Rajabi, Mohammad Bagher; Hasanlou, Narges; Abtahi, Seyed-Mojtaba; Goldberg, Robert A

2014-08-01

To investigate any correlation between lower lid retraction and proptosis and also between lower lid retraction and lamellar length, as measured by fornix depth, in patients with thyroid eye disease (TED). One hundred and sixty-six eyes of 83 patients with TED were enrolled. The inferior fornix depth, Hertel exophthalmometry measurement, clinical activity score, and lower lid position were the main outcome variables. The correlation between lower lid position measurement and Hertel measurements and also between the lower lid position measurement and inferior fornix depth were evaluated using ANOVA and Pearson's tests. The mean age of subjects in patients with and without lid retraction was 42.8 ± 1.5 and 47.7 ± 1.6 years, respectively (P = 0.4). The inferior fornix depth in patients with and without lower lid retraction was 11.8 ± 1.5 and 11.8 ± 1.3 mm, respectively (P = 0.960). Pearson's analysis showed a significant correlation between the degree of proptosis and lower lid retraction in TED patients (P = 0.01). However, no significant correlation was found between the level of lower lid retraction and the fornix depth (P = 0.87). The main cause of lower lid retraction in TED is proptosis. The beneficial effect of orbital decompression on improvement of lower lid retraction must be considered during a stepwise surgical approach in TED patients.

International Low Impact Docking System (iLIDS) Project Technical Requirements Specification, Revision F

NASA Technical Reports Server (NTRS)

Lewis, James L.

2011-01-01

The NASA Docking System (NDS) is NASA's implementation for the emerging International Docking System Standard (IDSS) using low impact docking technology. The NASA Docking System Project (NDSP) is the International Space Station (ISS) Program's project to produce the NDS, Common Docking Adapter (CDA) and Docking Hub. The NDS design evolved from the Low Impact Docking System (LIDS). The acronym international Low Impact Docking System (iLIDS) is also used to describe this system as well as the Government Furnished Equipment (GFE) project designing the NDS for the NDSP. NDS and iLIDS may be used interchangeability. This document will use the acronym iLIDS. Some of the heritage documentation and implementations (e.g., software command names, requirement identification (ID), figures, etc.) used on NDS will continue to use the LIDS acronym. This specification defines the technical requirements for the iLIDS GFE delivered to the NDSP by the iLIDS project. This document contains requirements for two iLIDS configurations, SEZ29101800-301 and SEZ29101800-302. Requirements with the statement, iLIDS shall, are for all configurations. Examples of requirements that are unique to a single configuration may be identified as iLIDS (-301) shall or iLIDS (-302) shall. Furthermore, to allow a requirement to encompass all configurations with an exception, the requirement may be designated as iLIDS (excluding -302) shall. Verification requirements for the iLIDS project are identified in the Verification Matrix (VM) provided in the iLIDS Verification and Validation Document, JSC-63966. The following definitions differentiate between requirements and other statements: Shall: This is the only verb used for the binding requirements. Should/May: These verbs are used for stating non-mandatory goals. Will: This verb is used for stating facts or declaration of purpose. A Definition of Terms table is provided in Appendix B to define those terms with specific tailored uses in this document.

MEMS packaging with etching and thinning of lid wafer to form lids and expose device wafer bond pads

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chanchani, Rajen; Nordquist, Christopher; Olsson, Roy H

In wafer-level packaging of microelectromechanical (MEMS) devices a lid wafer is bonded to a MEMS wafer in a predermined aligned relationship. Portions of the lid wafer are removed to separate the lid wafer into lid portions that respectively correspond in alignment with MEMS devices on the MEMS wafer, and to expose areas of the MEMS wafer that respectively contain sets of bond pads respectively coupled to the MEMS devices.

A simple technique to reduce evaporation of crystallization droplets by using plate lids with apertures for adding liquids.

PubMed

Zipper, Lauren E; Aristide, Xavier; Bishop, Dylan P; Joshi, Ishita; Kharzeev, Julia; Patel, Krishna B; Santiago, Brianna M; Joshi, Karan; Dorsinvil, Kahille; Sweet, Robert M; Soares, Alexei S

2014-12-01

A method is described for using plate lids to reduce evaporation in low-volume vapor-diffusion crystallization experiments. The plate lids contain apertures through which the protein and precipitants were added to different crystallization microplates (the reservoir was filled before fitting the lids). Plate lids were designed for each of these commonly used crystallization microplates. This system minimizes the dehydration of crystallization droplets containing just a few nanolitres of protein and precipitant, and results in more reproducible diffraction from the crystals. For each lid design, changes in the weight of the plates were used to deduce the rate of evaporation under different conditions of temperature, air movement, droplet size and precipitant. For comparison, the state of dehydration was also visually assessed throughout the experiment. Finally, X-ray diffraction methods were used to compare the diffraction of protein crystals that were conventionally prepared against those that were prepared on plates with plate lids. The measurements revealed that the plate lids reduced the rate of evaporation by 63-82%. Crystals grown in 5 nl drops that were set up with plate lids diffracted to higher resolution than similar crystals from drops that were set up without plate lids. The results demonstrate that plate lids can be instrumental for improving few-nanolitre crystallizations.

46 CFR 194.10-20 - Magazine chest construction.

Code of Federal Regulations, 2012 CFR

2012-10-01

... lid shall have a minimum thickness of 1/8 inch. (b) Permanent sun shields shall be provided for sides... distance of 11/2 inches. Sun shields may be omitted when chests are installed “on deck protected,” shielded from direct exposure to the sun. (c) Chests shall be limited to a gross capacity of 100 cubic feet. (d...

46 CFR 194.10-20 - Magazine chest construction.

Code of Federal Regulations, 2010 CFR

2010-10-01

... lid shall have a minimum thickness of 1/8 inch. (b) Permanent sun shields shall be provided for sides... distance of 11/2 inches. Sun shields may be omitted when chests are installed “on deck protected,” shielded from direct exposure to the sun. (c) Chests shall be limited to a gross capacity of 100 cubic feet. (d...

46 CFR 194.10-20 - Magazine chest construction.

Code of Federal Regulations, 2014 CFR

2014-10-01

... lid shall have a minimum thickness of 1/8 inch. (b) Permanent sun shields shall be provided for sides... distance of 11/2 inches. Sun shields may be omitted when chests are installed “on deck protected,” shielded from direct exposure to the sun. (c) Chests shall be limited to a gross capacity of 100 cubic feet. (d...

46 CFR 194.10-20 - Magazine chest construction.

Code of Federal Regulations, 2011 CFR

2011-10-01

... lid shall have a minimum thickness of 1/8 inch. (b) Permanent sun shields shall be provided for sides... distance of 11/2 inches. Sun shields may be omitted when chests are installed “on deck protected,” shielded from direct exposure to the sun. (c) Chests shall be limited to a gross capacity of 100 cubic feet. (d...

46 CFR 194.10-20 - Magazine chest construction.

Code of Federal Regulations, 2013 CFR

2013-10-01

... lid shall have a minimum thickness of 1/8 inch. (b) Permanent sun shields shall be provided for sides... distance of 11/2 inches. Sun shields may be omitted when chests are installed “on deck protected,” shielded from direct exposure to the sun. (c) Chests shall be limited to a gross capacity of 100 cubic feet. (d...

Deployment, release and recovery of ocean riser pipes

DOEpatents

Person, Abraham; Wetmore, Sherman B.; McNary, James F.

1980-11-18

An ocean thermal energy conversion facility includes a long pipe assembly which is supported at its upper end by the hull of the floating facility. Cold water flows to the facility from deep in the ocean. The pipe assembly comprises an elongate pipe construction and a weight connected to the lower end of the construction by a line of selected length. A floatation collar is connected to the construction at its upper end to cause the construction to have positive buoyancy and a center of buoyancy closer to the upper end of the construction than its center of mass. The weight renders the entire pipe assembly negatively buoyant. In the event that support of the pipe assembly should be lost, as by release of the assembly from the facility hull in an emergency, the assembly sinks to the ocean floor where it is moored by the weight. The pipe construction floats submerged above the ocean floor in a substantially vertical attitude which facilitates recovery of the assembly.

46 CFR 161.010-2 - Design, construction, and test requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 6 2013-10-01 2013-10-01 false Design, construction, and test requirements. 161.010-2 Section 161.010-2 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL ELECTRICAL EQUIPMENT Floating Electric Waterlight § 161.010-2 Design, construction, and test...

46 CFR 161.010-2 - Design, construction, and test requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 6 2010-10-01 2010-10-01 false Design, construction, and test requirements. 161.010-2 Section 161.010-2 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL ELECTRICAL EQUIPMENT Floating Electric Waterlight § 161.010-2 Design, construction, and test...

46 CFR 161.010-2 - Design, construction, and test requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 6 2014-10-01 2014-10-01 false Design, construction, and test requirements. 161.010-2 Section 161.010-2 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL ELECTRICAL EQUIPMENT Floating Electric Waterlight § 161.010-2 Design, construction, and test...

46 CFR 161.010-2 - Design, construction, and test requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 6 2011-10-01 2011-10-01 false Design, construction, and test requirements. 161.010-2 Section 161.010-2 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL ELECTRICAL EQUIPMENT Floating Electric Waterlight § 161.010-2 Design, construction, and test...

[Autogenous tarsus transplant as spacer for treatment of lower lid retraction in Grave's disease].

PubMed

Schittkowski, M P; Fichter, N; Guthoff, R F

2008-08-01

Lower lid retraction in dysthyroid orbitopathy is of less functional concern than optic neuropathy or diplopia in central positions of gaze. However, it may lead to incomplete lid closure resulting in corneal exposure. Patients often suffer from aesthetic impairment. A retrospective analysis of 13 consecutive patients treated for lower lid retraction due to Grave's Disease between 2005 and 2007 was undertaken. In spite of regular ophthalmological examinations, specific attention was directed to measurement of the lid fissure width and scleral show for quantification of lower lid retraction. OPERATION: The lower lid is everted and the conjunctiva is opened horizontally underneath the tarsal edge. Lower lid retractors are disinserted and dissected until the lower lid might be elevated in symmetry to the fellow eye. This procedure is continued until 1 mm overcorrection is gained. A free tarsal transplant is harvested from the ipsilateral upper lid tarsus. At least 4 mm vertical tarsus have to be left. Tarsus is sutured with absorbable material. In the 13 patients operated upon (9 women, 4 men) aged 23 - 67 years, scleral show was preoperative 2.7 mm (mean) and postoperative 0.1 mm. Lid fissure width was preoperative 13 mm (10 - 16 mm) and immediately postoperative 10.3 mm (7 - 13). 6 months postoperative the lid-elevating effect was reduced by 0.5 mm in maximum in the 9 patients available for control. The lid closure deficit, which was present in 7 patients before, could be corrected completely in 5 and diminished to 1 mm in 2 patients. Using this particular technique, functional and aesthetical satisfying results are obtained. The main advantages are renunciation of allogen, xenogeny or synthetic material with its possible risks of slow-virus infection and/or extrusion. Further studies are necessary to evaluate long-term results.

A simple technique to reduce evaporation of crystallization droplets by using plate lids with apertures for adding liquids

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zipper, Lauren E.; Binghamton University, 4400 Vestal Parkway East, Vestal, NY 13902; Aristide, Xavier

This article describes the use of evaporation control lids that are fitted to crystallization plates to improve the reproducibility of trials using as little as 5 nl. The plate lids contain apertures which are large enough for the transfer of protein containing droplets, but small enough to greatly reduce the rate of evaporation during the time needed to prepare the plate. A method is described for using plate lids to reduce evaporation in low-volume vapor-diffusion crystallization experiments. The plate lids contain apertures through which the protein and precipitants were added to different crystallization microplates (the reservoir was filled before fittingmore » the lids). Plate lids were designed for each of these commonly used crystallization microplates. This system minimizes the dehydration of crystallization droplets containing just a few nanolitres of protein and precipitant, and results in more reproducible diffraction from the crystals. For each lid design, changes in the weight of the plates were used to deduce the rate of evaporation under different conditions of temperature, air movement, droplet size and precipitant. For comparison, the state of dehydration was also visually assessed throughout the experiment. Finally, X-ray diffraction methods were used to compare the diffraction of protein crystals that were conventionally prepared against those that were prepared on plates with plate lids. The measurements revealed that the plate lids reduced the rate of evaporation by 63–82%. Crystals grown in 5 nl drops that were set up with plate lids diffracted to higher resolution than similar crystals from drops that were set up without plate lids. The results demonstrate that plate lids can be instrumental for improving few-nanolitre crystallizations.« less

A simple technique to reduce evaporation of crystallization droplets by using plate lids with apertures for adding liquids

PubMed Central

Zipper, Lauren E.; Aristide, Xavier; Bishop, Dylan P.; Joshi, Ishita; Kharzeev, Julia; Patel, Krishna B.; Santiago, Brianna M.; Joshi, Karan; Dorsinvil, Kahille; Sweet, Robert M.; Soares, Alexei S.

2014-01-01

A method is described for using plate lids to reduce evaporation in low-volume vapor-diffusion crystallization experiments. The plate lids contain apertures through which the protein and precipitants were added to different crystallization microplates (the reservoir was filled before fitting the lids). Plate lids were designed for each of these commonly used crystallization microplates. This system minimizes the dehydration of crystallization droplets containing just a few nanolitres of protein and precipitant, and results in more reproducible diffraction from the crystals. For each lid design, changes in the weight of the plates were used to deduce the rate of evaporation under different conditions of temperature, air movement, droplet size and precipitant. For comparison, the state of dehydration was also visually assessed throughout the experiment. Finally, X-ray diffraction methods were used to compare the diffraction of protein crystals that were conventionally prepared against those that were prepared on plates with plate lids. The measurements revealed that the plate lids reduced the rate of evaporation by 63–82%. Crystals grown in 5 nl drops that were set up with plate lids diffracted to higher resolution than similar crystals from drops that were set up without plate lids. The results demonstrate that plate lids can be instrumental for improving few-nanolitre crystallizations. PMID:25484231

Transcriptional transactivator peptide modified lidocaine-loaded nanoparticulate drug delivery system for topical anesthetic therapy.

PubMed

Wang, Yan; Wang, Shenhui; Shi, Pengcai

2016-11-01

For the topical anesthetic, transcriptional transactivator peptide (TAT) modified lidocaine (LID) loaded nanostructured lipid carriers (TAT-NLCs-LID) were prepared and then used for improving transdermal delivery of local anesthetic drug. In this study, TAT was conjugated with Distearoyl phosphatidylethanolamine-(polyethylene glycol) 2000 -maleimide (DSPE-PEG 2000 -Mal) to obtain TAT-PEG 2000 -DSPE. TAT-NLCs-LID were successfully prepared and characterized by determination of their particle size, morphology, drug encapsulation efficiency and in vitro drug release behavior. The skin permeation of LID-LNPs was examined using a Franz diffusion cell mounted with depilated mouse skin in vitro and in vivo anesthesia effect was evaluated on mice. The results showed that TAT-NLCs-LID have substantially small mean diameter (157.9 nm) and high encapsulation efficiency (81.8%). From the in vitro skin permeation results, transdermal flux of TAT-NLCs-LID was about several times higher than that of LID solution and NLCs-LID. In vivo anesthesia effect evaluation illustrated that TAT-NLCs-LID can enhance the transdermal delivery of LID by reducing the pain threshold in mice. These results indicate that the novel TAT containing drug delivery system is very useful for overcoming the barrier function of the skin and could deliver anesthetic through the skin. TAT-NLCs-LID could function as promising topical anesthetic system.

A simple technique to reduce evaporation of crystallization droplets by using plate lids with apertures for adding liquids

DOE PAGES

Zipper, Lauren E.; Aristide, Xavier; Bishop, Dylan P.; ...

2014-11-28

A method is described for using plate lids to reduce evaporation in low-volume vapor-diffusion crystallization experiments. The plate lids contain apertures through which the protein and precipitants were added to different crystallization microplates (the reservoir was filled before fitting the lids). Plate lids were designed for each of these commonly used crystallization microplates. This system minimizes the dehydration of crystallization droplets containing just a few nanolitres of protein and precipitant, and results in more reproducible diffraction from the crystals. For each lid design, changes in the weight of the plates were used to deduce the rate of evaporation under differentmore » conditions of temperature, air movement, droplet size and precipitant. For comparison, the state of dehydration was also visually assessed throughout the experiment. Finally, X-ray diffraction methods were used to compare the diffraction of protein crystals that were conventionally prepared against those that were prepared on plates with plate lids. The measurements revealed that the plate lids reduced the rate of evaporation by 63–82%. Crystals grown in 5 nl drops that were set up with plate lids diffracted to higher resolution than similar crystals from drops that were set up without plate lids. Ultimately, the results demonstrate that plate lids can be instrumental for improving few-nanolitre crystallizations.« less

Modeling the effects of LID practices on streams health at watershed scale

NASA Astrophysics Data System (ADS)

Shannak, S.; Jaber, F. H.

2013-12-01

Increasing impervious covers due to urbanization will lead to an increase in runoff volumes, and eventually increase flooding. Stream channels adjust by widening and eroding stream bank which would impact downstream property negatively (Chin and Gregory, 2001). Also, urban runoff drains in sediment bank areas in what's known as riparian zones and constricts stream channels (Walsh, 2009). Both physical and chemical factors associated with urbanization such as high peak flows and low water quality further stress aquatic life and contribute to overall biological condition of urban streams (Maxted et al., 1995). While LID practices have been mentioned and studied in literature for stormwater management, they have not been studied in respect to reducing potential impact on stream health. To evaluate the performance and the effectiveness of LID practices at a watershed scale, sustainable detention pond, bioretention, and permeable pavement will be modeled at watershed scale. These measures affect the storm peak flows and base flow patterns over long periods, and there is a need to characterize their effect on stream bank and bed erosion, and aquatic life. These measures will create a linkage between urban watershed development and stream conditions specifically biological health. The first phase of this study is to design and construct LID practices at the Texas A&M AgriLife Research and Extension Center-Dallas, TX to collect field data about the performance of these practices on a smaller scale. The second phase consists of simulating the performance of LID practices on a watershed scale. This simulation presents a long term model (23 years) using SWAT to evaluate the potential impacts of these practices on; potential stream bank and bed erosion, and potential impact on aquatic life in the Blunn Watershed located in Austin, TX. Sub-daily time step model simulations will be developed to simulate the effectiveness of the three LID practices with respect to reducing potential erosion from stream beds and banks by studying annual average excess shear and reducing potential impact on aquatic life by studying rapid changes and variation in flow regimes in urban streams. This study will contribute to develop a methodology that evaluates the impact of hydrological changes that occur due to urban development, on aquatic life, stream bank and bed erosion. This is an ongoing research project and results will be shared and discussed at the conference.

Food packing optimization

NASA Technical Reports Server (NTRS)

1981-01-01

The development of a universal closure lid for the space shuttle food package is reported. The revised lid needs a folded configuration which, when unfolded, fully conforms to the interior surfaces of the food cup. Experimental thermoform molds were fabricated and test lids formed. The lid material not in contact with the food conformed to the cup interior without wrinkles, permitting full nesting of the cups. The final lid design was established and thermoform tooling designed and fabricated. Lids formed on these molds were tested for strength. The heating elements were replaced and repositioned to eliminate any hot spots which may cause warpage.

Serotonergic mechanisms responsible for levodopa-induced dyskinesias in Parkinson’s disease patients

PubMed Central

Politis, Marios; Wu, Kit; Loane, Clare; Brooks, David J.; Kiferle, Lorenzo; Turkheimer, Federico E.; Bain, Peter; Molloy, Sophie; Piccini, Paola

2014-01-01

Levodopa-induced dyskinesias (LIDs) are the most common and disabling adverse motor effect of therapy in Parkinson’s disease (PD) patients. In this study, we investigated serotonergic mechanisms in LIDs development in PD patients using 11C-DASB PET to evaluate serotonin terminal function and 11C-raclopride PET to evaluate dopamine release. PD patients with LIDs showed relative preservation of serotonergic terminals throughout their disease. Identical levodopa doses induced markedly higher striatal synaptic dopamine concentrations in PD patients with LIDs compared with PD patients with stable responses to levodopa. Oral administration of the serotonin receptor type 1A agonist buspirone prior to levodopa reduced levodopa-evoked striatal synaptic dopamine increases and attenuated LIDs. PD patients with LIDs that exhibited greater decreases in synaptic dopamine after buspirone pretreatment had higher levels of serotonergic terminal functional integrity. Buspirone-associated modulation of dopamine levels was greater in PD patients with mild LIDs compared with those with more severe LIDs. These findings indicate that striatal serotonergic terminals contribute to LIDs pathophysiology via aberrant processing of exogenous levodopa and release of dopamine as false neurotransmitter in the denervated striatum of PD patients with LIDs. Our results also support the development of selective serotonin receptor type 1A agonists for use as antidyskinetic agents in PD. PMID:24531549

Retrofitting LID Practices into Existing Neighborhoods: Is It Worth It?

NASA Astrophysics Data System (ADS)

Wright, Timothy J.; Liu, Yaoze; Carroll, Natalie J.; Ahiablame, Laurent M.; Engel, Bernard A.

2016-04-01

Low-impact development (LID) practices are gaining popularity as an approach to manage stormwater close to the source. LID practices reduce infrastructure requirements and help maintain hydrologic processes similar to predevelopment conditions. Studies have shown LID practices to be effective in reducing runoff and improving water quality. However, little has been done to aid decision makers in selecting the most effective practices for their needs and budgets. The long-term hydrologic impact assessment LID model was applied to four neighborhoods in Lafayette, Indiana using readily available data sources to compare LID practices by analyzing runoff volumes, implementation cost, and the approximate period needed to achieve payback on the investment. Depending on the LID practice and adoption level, 10-70 % reductions in runoff volumes could be achieved. The cost per cubic meter of runoff reduction was highly variable depending on the LID practice and the land use to which it was applied, ranging from around 3 to almost 600. In some cases the savings from reduced runoff volumes paid back the LID practice cost with interest in less than 3 years, while in other cases it was not possible to generate a payback. Decision makers need this information to establish realistic goals and make informed decisions regarding LID practices before moving into detailed designs, thereby saving time and resources.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zipper, Lauren E.; Aristide, Xavier; Bishop, Dylan P.

A method is described for using plate lids to reduce evaporation in low-volume vapor-diffusion crystallization experiments. The plate lids contain apertures through which the protein and precipitants were added to different crystallization microplates (the reservoir was filled before fitting the lids). Plate lids were designed for each of these commonly used crystallization microplates. This system minimizes the dehydration of crystallization droplets containing just a few nanolitres of protein and precipitant, and results in more reproducible diffraction from the crystals. For each lid design, changes in the weight of the plates were used to deduce the rate of evaporation under differentmore » conditions of temperature, air movement, droplet size and precipitant. For comparison, the state of dehydration was also visually assessed throughout the experiment. Finally, X-ray diffraction methods were used to compare the diffraction of protein crystals that were conventionally prepared against those that were prepared on plates with plate lids. The measurements revealed that the plate lids reduced the rate of evaporation by 63–82%. Crystals grown in 5 nl drops that were set up with plate lids diffracted to higher resolution than similar crystals from drops that were set up without plate lids. Ultimately, the results demonstrate that plate lids can be instrumental for improving few-nanolitre crystallizations.« less

Sharps container

NASA Technical Reports Server (NTRS)

Lee, Angelene M. (Inventor)

1992-01-01

This invention relates to a system for use in disposing of potentially hazardous items and more particularly a Sharps receptacle for used hypodermic needles and the like. A Sharps container is constructed from lightweight alodined nonmagnetic metal material with a cup member having an elongated tapered shape and length greater than its transverse dimensions. A magnet in the cup member provides for metal retention in the container. A nonmagnetic lid member has an opening and spring biased closure flap member. The flap member is constructed from stainless steel. A Velcro patch on the container permits selective attachment at desired locations.

Pot/Lid Illusion

PubMed Central

Kennedy, John M.

2016-01-01

A new everyday visual size illusion is presented—the Pot/Lid illusion. Observers choose an unduly large lid for a pot. We ask whether the optic slant of the pot brim would increase its apparent size or if vision underestimates the size of tilted lids. PMID:27698990

40 CFR Table 28 to Subpart G of... - Deck Seam Length Factors a (SD) for Internal Floating Roof Tanks

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 9 2011-07-01 2011-07-01 false Deck Seam Length Factors a (SD) for... (SD) for Internal Floating Roof Tanks Deck construction Typical deck seam length factor Continuous... decks only. Units for SD are feet per square feet. b SD=1/W, where W = sheet width (feet). c If no...

40 CFR Table 28 to Subpart G of... - Deck Seam Length Factors a (SD) for Internal Floating Roof Tanks

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 9 2010-07-01 2010-07-01 false Deck Seam Length Factors a (SD) for... (SD) for Internal Floating Roof Tanks Deck construction Typical deck seam length factor Continuous... decks only. Units for SD are feet per square feet. b SD=1/W, where W = sheet width (feet). c If no...

Research on the effect of rainfall flood regulation and control of wetland park based on SWMM model—a case study of wetland park in Yuanjia village, Qishan county, Shaanxi province

NASA Astrophysics Data System (ADS)

Xu, Da; Liu, Yijie

2018-02-01

Taking the wetland park of Yuan Village in Qishan County of Shaanxi Province as the research object, this paper makes a reasonable generalization of the study area, and establishes two models of low impact development (LID) and traditional development in the park. Meantime, rainwater in the surrounding built up area is introduced to into the park for digestion. SWMM model is used to simulate the variation of the total runoff, peak flow and peak time of two development models in Wetland Park under one-hour rainfall at different recurrence periods.The runoff control effect in each single LID facility in the one-hour rainfall once during five years in the built-up area is simulated. The simulation results show that the SWMM model can not only quantify the runoff reduction effect of different LID facilities, but also provide theoretical basis and data support for the urban rainfall flood problem. LID facilities have effects on runoff reduction and peak delay. However, the combined LID facility has obvious advantages for the peak time delay and peak flow control. A single LID facility is more efficient in a single runoff volume control. The order of runoff reduction by various LID facilities is as follows: Rain garden>combined LID facility> vegetative swale> bio-retention cell > permeable pavement. The order of peak time delay effect by the LID facilities is as follows: combined LID facility> Rain garden> vegetative swale> bio-retention cell > permeable pavement. The order of peak flow reduction efficiency by various LID facilities is: combined LID facility> Rain garden> bio-retention cell > vegetative swale> permeable pavement.

Enhancing a rainfall-runoff model to assess the impacts of BMPs and LID practices on storm runoff.

PubMed

Liu, Yaoze; Ahiablame, Laurent M; Bralts, Vincent F; Engel, Bernard A

2015-01-01

Best management practices (BMPs) and low impact development (LID) practices are increasingly being used as stormwater management techniques to reduce the impacts of urban development on hydrology and water quality. To assist planners and decision-makers at various stages of development projects (planning, implementation, and evaluation), user-friendly tools are needed to assess the effectiveness of BMPs and LID practices. This study describes a simple tool, the Long-Term Hydrologic Impact Assessment-LID (L-THIA-LID), which is enhanced with additional BMPs and LID practices, improved approaches to estimate hydrology and water quality, and representation of practices in series (meaning combined implementation). The tool was used to evaluate the performance of BMPs and LID practices individually and in series with 30 years of daily rainfall data in four types of idealized land use units and watersheds (low density residential, high density residential, industrial, and commercial). Simulation results were compared with the results of other published studies. The simulated results showed that reductions in runoff volume and pollutant loads after implementing BMPs and LID practices, both individually and in series, were comparable with the observed impacts of these practices. The L-THIA-LID 2.0 model is capable of assisting decision makers in evaluating environmental impacts of BMPs and LID practices, thereby improving the effectiveness of stormwater management decisions. Copyright © 2014 Elsevier Ltd. All rights reserved.

Lid for improved dendritic web growth

DOEpatents

Duncan, Charles S.; Kochka, Edgar L.; Piotrowski, Paul A.; Seidensticker, Raymond G.

1992-03-24

A lid for a susceptor in which a crystalline material is melted by induction heating to form a pool or melt of molten material from which a dendritic web of essentially a single crystal of the material is pulled through an elongated slot in the lid and the lid has a pair of generally round openings adjacent the ends of the slot and a groove extends between each opening and the end of the slot. The grooves extend from the outboard surface of the lid to adjacent the inboard surface providing a strip contiguous with the inboard surface of the lid to produce generally uniform radiational heat loss across the width of the dendritic web adjacent the inboard surface of the lid to reduce thermal stresses in the web and facilitate the growth of wider webs at a greater withdrawal rate.

Anti-natural octyl disaccharide-leprosy IDRI diagnostic (NDO-LID) antibodies as indicators of leprosy reactions and neuritis.

PubMed

Serrano-Coll, Héctor; Muñoz, Mónica; Camilo Beltrán, Juan; Duthie, Malcolm S; Cardona-Castro, Nora

2017-03-01

Leprosy is a complex infectious and neurological disease caused by Mycobacterium leprae. Nerve damage is related to immunological hypersensitivity responses known as leprosy reactions (LRs). Diagnostic tools to predict LRs are not available. We hypothesized that natural octyl disaccharide-leprosy IDRI diagnostic (NDO-LID) would be helpful as an indicator of LRs and neuritis. To assess the utility of NDO-LID in indicating reactions, ELISA were used to detect specific antibodies in serum samples from 80 Colombian leprosy patients (40 with and 40 without history of LRs). Responses were detected using a range of detection reagents detecting IgG, IgM or both isotypes. Patients with a history of LRs had an increased seropositivity rate for anti-NDO-LID antibodies compared to patients without (anti-NDO-LID protein A [p=0.02], IgG anti-NDO-LID [p=0.01] and IgM anti-NDO-LID [p=0.01]). Further analyses of patients with a history of LRs indicated that both seropositivity rate and magnitude of responses were elevated among patients with neuritis versus those without neuritis (anti-NDO-LID protein A [p=0.03], IgG anti-NDO-LID [p=0.001] and IgM anti-NDO-LID [p=0.06]). Our data indicate that testing for serum anti-NDO-LID antibodies can be a useful screen to identify patients at risk of developing LRs and neuritis. © The Author 2017. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Microneedle-assisted permeation of lidocaine carboxymethylcellulose with gelatine co-polymer hydrogel.

PubMed

Nayak, Atul; Das, Diganta B; Vladisavljević, Goran T

2014-05-01

Lidocaine hydrochloride (LidH) was formulated in sodium carboxymethyl cellulose/ gelatine (NaCMC/GEL) hydrogel and a 'poke and patch' microneedle delivery method was used to enhance permeation flux of LidH. The microparticles were formed by electrostatic interactions between NaCMC and GEL macromolecules within a water/oil emulsion in paraffin oil and the covalent crosslinking was by glutaraldehyde. The GEL to NaCMC mass ratio was varied between 1.6 and 2.7. The LidH encapsulation yield was 1.2 to 7% w/w. LidH NaCMC/GEL was assessed for encapsulation efficiency, zeta potential, mean particle size and morphology. Subsequent in vitro skin permeation studies were performed via passive diffusion and microneedle assisted permeation of LidH NaCMC/GEL to determine the maximum permeation rate through full thickness skin. LidH 2.4% w/w NaCMC/GEL 1:1.6 and 1:2.3 respectively, possessed optimum zeta potential. LidH 2.4% w/w NaCMC/GEL 1:2.3 and 1:2.7 demonstrate higher pseudoplastic behaviour. Encapsulation efficiency (14.9-17.2%) was similar for LidH 2.4% w/w NaCMC/GEL 1:1.6-1:2.3. Microneedle assisted permeation flux was optimum for LidH 2.4% w/w NaCMC/GEL 1:2.3 at 6.1 μg/ml/h. LidH 2.4% w/w LidH NaCMC/GEL 1:2.3 crossed the minimum therapeutic drug threshold with microneedle skin permeation in less than 70 min.

Low Impact Development Master Plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

Loftin, Samuel R.

This project creates a Low Impact Development (LID) Master Plan to guide and prioritize future development of LID projects at Los Alamos National Laboratory (LANL or the Laboratory). The LID Master Plan applies to developed areas across the Laboratory and focuses on identifying opportunities for storm water quality and hydrological improvements in the heavily urbanized areas of Technical Areas 03, 35 and 53. The LID Master Plan is organized to allow the addition of LID projects for other technical areas as time and funds allow in the future.

Learning to assign binary weights to binary descriptor

NASA Astrophysics Data System (ADS)

Huang, Zhoudi; Wei, Zhenzhong; Zhang, Guangjun

2016-10-01

Constructing robust binary local feature descriptors are receiving increasing interest due to their binary nature, which can enable fast processing while requiring significantly less memory than their floating-point competitors. To bridge the performance gap between the binary and floating-point descriptors without increasing the computational cost of computing and matching, optimal binary weights are learning to assign to binary descriptor for considering each bit might contribute differently to the distinctiveness and robustness. Technically, a large-scale regularized optimization method is applied to learn float weights for each bit of the binary descriptor. Furthermore, binary approximation for the float weights is performed by utilizing an efficient alternatively greedy strategy, which can significantly improve the discriminative power while preserve fast matching advantage. Extensive experimental results on two challenging datasets (Brown dataset and Oxford dataset) demonstrate the effectiveness and efficiency of the proposed method.

Quality of life associated with perceived stigma and discrimination among the floating population in Shanghai, China: a qualitative study.

PubMed

Wang, Ji-Wei; Cui, Zhi-Ting; Cui, Hong-Wei; Wei, Chang-Nian; Harada, Koichi; Minamoto, Keiko; Ueda, Kimiyo; Ingle, Kapilkumar N; Zhang, Cheng-Gang; Ueda, Atsushi

2010-12-01

The floating population refers to the large and increasing number of migrants without local household registration status and has become a new demographic phenomenon in China. Most of these migrants move from the rural areas of the central and western parts of China to the eastern and coastal metropolitan areas in pursuit of a better life. The floating population of China was composed of 121 million people in 2000, and this number was expected to increase to 300 million by 2010. Quality of life (QOL) studies of the floating population could provide a critical starting point for recognizing the potential of regions, cities and local communities to improve QOL. This study explored the construct of QOL of the floating population in Shanghai, China. We conducted eight focus groups with 58 members of the floating population (24 males and 34 females) and then performed a qualitative thematic analysis of the interviews. The following five QOL domains were identified from the analysis: personal development, jobs and career, family life, social relationships and social security. The results indicated that stigma and discrimination permeate these life domains and influence the framing of life expectations. Proposals were made for reducing stigma and discrimination against the floating population to improve the QOL of this population.

Transdermal Bioavailability in Rats of Lidocaine in the Forms of Ionic Liquids, Salts, and Deep Eutectic.

PubMed

Berton, Paula; Di Bona, Kristin R; Yancey, Denise; Rizvi, Syed A A; Gray, Marquita; Gurau, Gabriela; Shamshina, Julia L; Rasco, Jane F; Rogers, Robin D

2017-05-11

Tuning the bioavailability of lidocaine was explored by its incorporation into the ionic liquid lidocainium docusate ([Lid][Doc]) and the deep eutectic Lidocaine·Ibuprofen (Lid·Ibu) and comparing the transdermal absorption of these with the crystalline salt lidocainium chloride ([Lid]Cl). Each form of lidocaine was dissolved in a vehicle cream and topically applied to Sprague-Dawley rats. The concentrations of the active pharmaceutical ingredients (APIs) in blood plasma were monitored over time as an indication of systemic absorption. The concentration of lidocaine in plasma varied between applied API-based creams, with faster and higher systemic absorption of the hydrogen bonded deep eutectic Lid·Ibu than the absorption of the salts [Lid]Cl or [Lid][Doc]. Interestingly, a differential transdermal absorption was observed between lidocaine and ibuprofen when Lid·Ibu was applied, possibly indicating different interactions with the tissue components.

Transdermal Bioavailability in Rats of Lidocaine in the Forms of Ionic Liquids, Salts, and Deep Eutectic

PubMed Central

2017-01-01

Tuning the bioavailability of lidocaine was explored by its incorporation into the ionic liquid lidocainium docusate ([Lid][Doc]) and the deep eutectic Lidocaine·Ibuprofen (Lid·Ibu) and comparing the transdermal absorption of these with the crystalline salt lidocainium chloride ([Lid]Cl). Each form of lidocaine was dissolved in a vehicle cream and topically applied to Sprague–Dawley rats. The concentrations of the active pharmaceutical ingredients (APIs) in blood plasma were monitored over time as an indication of systemic absorption. The concentration of lidocaine in plasma varied between applied API-based creams, with faster and higher systemic absorption of the hydrogen bonded deep eutectic Lid·Ibu than the absorption of the salts [Lid]Cl or [Lid][Doc]. Interestingly, a differential transdermal absorption was observed between lidocaine and ibuprofen when Lid·Ibu was applied, possibly indicating different interactions with the tissue components. PMID:28523100

The effect of floating vegetation on denitrification and greenhouse gas production in wetland mesocosms

NASA Astrophysics Data System (ADS)

Jacobs, A. E.; Harrison, J. A.

2012-12-01

Anthropogenic intensification of nitrogen (N) loading to aquatic ecosystems is widespread and can lead to the degradation of these systems. Wetlands are important sites for N removal via denitrification, the microbially mediated reduction of reactive nitrate to inert N2 gas, but they can also produce high levels of greenhouse gases. Floating plants play an important role in encouraging denitrification, since they create low oxygen conditions that may favor denitrification. We investigated whether wetland sediments with floating plant cover had higher denitrification and greenhouse gas production rates than wetland sediments without floating plants. Replicate flow-through mesocosms with wetland sediment and water were constructed in a growth chamber to mimic the wetland where the sediment and water were collected. Mesocosm treatments were covered with floating vegetation (duckweed), an opaque tarp, or no cover to determine how cover type affects denitrification and greenhouse gas production and whether biotic or abiotic factors are likely responsible for observed differences. Denitrification and greenhouse gas production rates were calculated by measuring excess N2 gas, methane, and nitrous oxide concentrations in the water column and measuring the gas exchange rates between the water column and the atmosphere. Gas exchange rates were measured using an inert volatile tracer added to the water column and accumulation of gas in the mesocosm headspace. Additional mesocosm experiments were performed to determine how duckweed-dominated wetland systems respond to nitrogen loading and which mechanism for lowering dissolved oxygen concentrations is important in affecting denitrification under floating vegetation. Mesocosms with floating vegetation had lower dissolved oxygen than no cover or tarp-covered mesocosms, which is consistent with field and literature observations. Water flowing out of the mesocosms had statistically lower total nitrogen and nitrate concentrations compared to inflow water, and calculated denitrification was statistically higher in the floating vegetation treatments compared to the other treatments. Greenhouse gas production, measured in CO2 equivalents for N2O and CH4, was highly variable and not statistically different between the treatments. Denitrification in the tarp covered mesocosms was similar to the no-cover treatment, indicating that biotic effects in the floating vegetation treatment may be important in lowering water column oxygen levels and increasing denitrification. Understanding how floating vegetation affects total nitrogen loss, denitrification, and greenhouse gas production can be used to weigh ecological costs and benefits of different vegetation types, especially in constructed and managed wetlands.

The Versatile Lid Crease Approach to Upper Eyelid Margin Rotation.

PubMed

Cruz, Antonio A V; Akaishi, Patricia M S; Al-Dufaileej, Mohammed; Galindo-Ferreiro, Alicia

2015-01-01

Lid margin rotational procedures have been used to correct cicatricial trachomatous entropion since the 19(th) century. There are two basic types of surgeries used for lid margin rotation. The first type is based on through-and-through approach combining tarsotomy and the use of sutures on the anterior lamella. The second type of surgery was suggested by Trabut, who proposed a tarsal advancement by posterior approach. We demonstrate that using a lid crease incision combines the basic mechanisms of the anterior and posterior approaches and in addition, addresses a variety of lid problems commonly found in the aged population with cicatricial entropion. After tarsal plate exposure, a tarsotomy through conjunctiva is performed as described by Trabut. Then, instead of using external sutures secured by bolsters, internal absorbable sutures can be used to simultaneously advance the distal tarsal fragment and exert strong tension on the marginal orbicularis muscle. Sixty lids of 40 patients underwent surgery with a lid crease incision. The follow-up ranged from 1 to 12 months (mean 3.0 months ± 2.71). Forty percent of the patients (24 lids) had more than 3 months of follow-up. Adequate margin rotation was achieved in all lids but one that showed a medial eyelash touching the cornea.

Compliance and Subjective Patient Responses to Eyelid Hygiene.

PubMed

Alghamdi, Yousef A; Camp, Andrew; Feuer, William; Karp, Carol L; Wellik, Sarah; Galor, Anat

2017-07-01

Lid hygiene is a commonly prescribed first-line therapy in patients with lid margin disease, yet compliance with therapy is not well characterized. The goals of this study were to assess patient compliance with lid hygiene and evaluate which factors predict a favorable symptomatic response to treatment. This was a cross-sectional study of patients seen in the Miami Veterans Affairs eye clinic between August and December 2014. An evaluation was performed to assess dry eye symptoms and lid margin signs. All patients were then instructed to perform warm compresses and lid scrubs. A follow-up phone survey assessed compliance and subjective therapeutic response 6 weeks later. Two hundred seven of 211 (98%) patients (94% male, 60% white) completed the survey. Of the 207 patients, 188 (91%) completed the follow-up survey. Compliance with therapy was reported in 104 patients (55%); 66 reported complete improvement, 30 partial improvement, and 8 no improvement in symptoms. Patients who self-reported dry eye symptoms at first visit (n=86, 74%) were more likely to be compliant with lid hygiene than those who did not report symptoms (n=18, 25%) (P<0.0005). The only factor associated with poorer response to lid hygiene was longer time of self-reported dry eye symptoms. None of the other signs studied, including the presence of skin rosacea and lid margin telangiectasia, were associated with a differential response to lid hygiene. Patients with dry eye symptoms were moderately compliant with lid hygiene, and patients who performed the routine noted improvement in symptoms.

Optogenetic activation of striatal cholinergic interneurons regulates L-dopa-induced dyskinesias

PubMed Central

Heiss, Jaime; Zhang, Danhui; Quik, Maryka

2016-01-01

L-dopa-induced dyskinesias (LIDs) are a serious complication of L-dopa therapy for Parkinson's disease. Emerging evidence indicates that the nicotinic cholinergic system plays a role in LIDs, although the pathways and mechanisms are poorly understood. Here we used optogenetics to investigate the role of striatal cholinergic interneurons in LIDs. Mice expressing cre-recombinase under the control of the choline acetyltransferase promoter (ChAT-Cre) were lesioned by unilateral injection of 6-hydroxydopamine. AAV5-ChR2-eYFP or AAV5-control-eYFP was injected into the dorsolateral striatum, and optical fibers implanted. After stable virus expression, mice were treated with L-dopa. They were then subjected to various stimulation protocols for 2 h and LIDs rated. Continuous stimulation with a short duration optical pulse (1-5 ms) enhanced LIDs. This effect was blocked by the general muscarinic acetylcholine receptor (mAChR) antagonist atropine indicating it was mAChR-mediated. By contrast, continuous stimulation with a longer duration optical pulse (20 ms to 1 s) reduced LIDs to a similar extent as nicotine treatment (~50%). The general nicotinic acetylcholine receptor (nAChR) antagonist mecamylamine blocked the decline in LIDs with longer optical pulses showing it was nAChR-mediated. None of the stimulation regimens altered LIDs in control-eYFP mice. Lesion-induced motor impairment was not affected by optical stimulation indicating that cholinergic transmission selectively regulates LIDs. Longer pulse stimulation increased the number of c-Fos expressing ChAT neurons, suggesting that changes in this immediate early gene may be involved. These results demonstrate that striatal cholinergic interneurons play a critical role in LIDs and support the idea that nicotine treatment reduces LIDs via nAChR desensitization. PMID:26921469

X-ray crystallographic and MD simulation studies on the mechanism of interfacial activation of a family I.3 lipase with two lids.

PubMed

Angkawidjaja, Clement; Matsumura, Hiroyoshi; Koga, Yuichi; Takano, Kazufumi; Kanaya, Shigenori

2010-07-02

The interfacial activation mechanism of family I.3 lipase from Pseudomonas sp. MIS38 (PML), which has two alpha-helical lids (lid1 and lid2), was investigated using a combination of X-ray crystallography and molecular dynamics (MD) simulation. The crystal structure of PML in an open conformation was determined at 2.1 A resolution in the presence of Ca(2+) and Triton X-100. Comparison of this structure with that in the closed conformation indicates that both lids greatly change their positions and lid1 is anchored by the calcium ion (Ca1) in the open conformation. This structure was not seriously changed even when the protein was dialyzed extensively against the Ca(2+)-free buffer containing Triton X-100 before crystallization, indicating that the open conformation is fairly stable unless a micellar substance is removed. The crystal structure of the PML derivative, in which the active site serine residue (Ser207) is diethylphosphorylated by soaking the crystal of PML in the open conformation in a solution containing diethyl p-nitrophenyl phosphate, was also determined. This structure greatly resembles that in the open conformation, indicating that PML structure in the open conformation represents that in the active form. MD simulation of PML in the open conformation in the absence of micelles showed that lid2 closes first, while lid1 maintains its open conformation. Likewise, MD simulation of PML in the closed conformation in the absence of Ca(2+) and in the presence of octane or trilaurin micelles showed that lid1 opens, while lid2 remains closed. These results suggest that Ca1 functions as a hook for stabilization of a fully opened conformation of lid1 and for initiation of subsequent opening of lid2. Copyright 2010 Elsevier Ltd. All rights reserved.

Scaling and Thermal Evolution of Internally Heated Planets: Yield Stress and Thermal History.

NASA Astrophysics Data System (ADS)

Weller, M. B.; Lenardic, A.; Moore, W. B.

2014-12-01

Using coupled 3D mantle convection and planetary tectonics models of bi-stable systems, we show how system behaviors for mobile-lid and stagnant-lid states scale as functions of internal heating rates (Q) and basal Ra (Rab). With parameter ranges for temperature- and depth-dependant viscosities: 1e4 - 3e4, Rab: 1e5- 3e5, Q: 0 - 100, and yield stress: 1e4 - 2e5, it can be shown the internal temperatures, velocities, heat fluxes, and system behaviors for mobile-lid and stagnant-lid states diverge, for equivalent parameter values, as a function of increasing Q. For the mobile-lid regime, yielding behavior in the upper boundary layer strongly influences the dynamics of the system. Internal temperatures, and consequently temperature-dependant viscosities, vary strongly as a function of yield stress for a given Q. The temperature distribution across the upper and lower mantles are sub-adiabatic for low to moderate yield stress, and adiabatic to super-adiabatic for high yield stresses. Across the parameter range considered, and for fixed yield stress, the Nu across the basal boundary (Nub) is positive and only weakly dependant on Q (varies by ~ 9%). Nub varies strongly as a function of yield stress (maximum variation of ~84%). Both mobile-lid velocities and lid-thicknesses are yield stress dependant for a given Q and Ra. In contrast to mobile-lids, the stagnant-lid regime is governed by the relative inefficiency of heat transport through the surface boundary layer. Internal temperatures are yield stress independent, and are on average 30% greater. Nub has a strong dependence on heating rates and surface boundary layer thicknesses. Within the parameter space considered, the maximum stagnant-lid Nub corresponds to the minimum mobile-lid Nub (for high yield stress), and decreases with increasing Q. For high Q, super-heated stagnant-lids may develop, with Nub< 0, and changes in trends for system behaviors. Planets with high levels of internal heating and/or high yield stresses (e.g. Super-Earths), may favor super-heated stagnant-lids early in their evolution. These regimes indicate reduced heat transport efficiencies (from the nominal stagnant-lid), and as a result, increasing heat flux into the core with increasing Q. Implications for terrestrial and Super-Earth planetary evolution will be discussed.

Employability Deconstructed: Perceptions of Bologna Stakeholders

ERIC Educational Resources Information Center

Sin, Cristina; Neave, Guy

2016-01-01

The paper analyses employability as a floating signifier--a construct that accommodates different and often contending meanings. A preliminary analysis of scholarly literature identifies two opposed interpretations of employability--an individual responsibility versus a comprehensive context-aware construct. These are subsequently applied to the…

Adjustable Lid Aids Silicon-Ribbon Growth

NASA Technical Reports Server (NTRS)

Mchugh, J. P.; Steidensticker, R. G.; Duncan, C. S.

1985-01-01

Closely-spaced crucible cover speeds up solidification. Growth rate of dendritic-web silicon ribbon from molten silicon increased by controlling distance between crucible susceptor lid and liquid/solid interface. Lid held in relatively high position when crucible newly filled with chunks of polycrystalline silicon. As silicon melts and forms pool of liquid at lower level, lid gradually lowered.

Void-Free Lid for Food Packaging

NASA Technical Reports Server (NTRS)

Watson, C. D.; Farris, W. P.

1986-01-01

Flexible cover eliminates air pockets in sealed container. Universal food-package lid formed from flexible plastic. Partially folded, lid unfolded by depressing center portion. Height of flat portion of lid above flange thereby reduced. Pressure of food against central oval depression pops it out, forming dome that provides finger grip for mixing contents with water or opening lid. Therefore food stays fresh, allows compact stacking of partially filled containers, and resists crushing. Originally developed for packaging dehydrated food for use in human consumption on Space Shuttle missions. Other uses include home canning and commercial food packaging.

Term Cancellations in Computing Floating-Point Gröbner Bases

NASA Astrophysics Data System (ADS)

Sasaki, Tateaki; Kako, Fujio

We discuss the term cancellation which makes the floating-point Gröbner basis computation unstable, and show that error accumulation is never negligible in our previous method. Then, we present a new method, which removes accumulated errors as far as possible by reducing matrices constructed from coefficient vectors by the Gaussian elimination. The method manifests amounts of term cancellations caused by the existence of approximate linearly dependent relations among input polynomials.

Pharmacological strategies for the management of levodopa-induced dyskinesia in patients with Parkinson's disease.

PubMed

Schaeffer, Eva; Pilotto, Andrea; Berg, Daniela

2014-12-01

L-Dopa-induced dyskinesias (LID) are the most common adverse effects of long-term dopaminergic therapy in Parkinson's disease (PD). However, the exact mechanisms underlying dyskinesia are still unclear. For a long time, nigrostriatal degeneration and pulsatile stimulation of striatal postsynaptic receptors have been highlighted as the key factors for the development of LID. In recent years, PD models have revealed a wide range of non-dopaminergic neurotransmitter systems involved in pre- and postsynaptic changes and thereby contributing to the pathophysiology of LID. In the current review, we focus on therapeutic LID targets, mainly based on agents acting on dopaminergic, glutamatergic, serotoninergic, adrenergic, and cholinergic systems. Despite a large number of clinical trials, currently only amantadine and, to a lesser extent, clozapine are being used as effective strategies in the treatment of LID in clinical settings. Thus, in the second part of the article, we review the placebo-controlled trials on LID treatment in order to disentangle the changing scenario of drug development. Promising results include the extension of L-dopa action without inducing LID of the novel monoamine oxidase B- and glutamate-release inhibitor safinamide; however, this had no obvious effect on existing LID. Others, like the metabotropic glutamate-receptor antagonist AFQ056, showed promising results in some of the studies; however, confirmation is still lacking. Thus, to date, strategies of continuous dopaminergic stimulation seem the most promising to prevent or ameliorate LID. The success of future therapeutic strategies once moderate to severe LID occur will depend on the translation from preclinical experimental models into clinical practice in a bidirectional process.

Review on the prevalence of diabetes and risk factors and situation of disease management in floating population in China.

PubMed

Han, Kaiyi; Yao, Jingjing; Yin, Xiao; Zhao, Mei; Sun, Qiang

2017-01-01

To give a comprehensive and basic understanding of diabetes and its risk factors in floating people in China. We use "(diabetes or type 2 diabetes or chronic disease) and (floating population or employed floating population)" as the key words to search in the China academic literature database (CNKI), Wan Fang database, PubMed and Web of Science for relevant literature and extract the data about the prevalence of diabetes, relevant risk factors and disease management of the floating population in China. Twenty-one literatures are entered into analysis finally, one is English and the rest are Chinese. According to the national survey, the prevalence rate of diabetes in floating population in China was 5. 1% (95%CI, 4.9% - 5.3%), which is lower than that of the general population(11.6%,95%CI, 11.3%-11.8%),and is consistent with the results of the local surveys. The comparison result between the prevalence of floating population and that of local population in each region differs in local surveys. In addition, the prevalence of male floating population is lower than that of the female population. Finally, as the age of the population rises, so does the prevalence of diabetes. As for the risk factors of chronical diseases, the overweight rate in every region is similar but the obesity rate differs in different regions (Ningxia,26.0%;Xiangshan,14.0%), and the obesity rate of the floating population is less than half of that of the general people(4.7%,11.9%). The awareness rate, treatment rate and control rate in the floating patients differ in the regional researches, but they all can't meet the goals set by the local health departments. Compared with the general population, the prevalence of diabetes in the floating population are lower. However, Considering the growing population number and the poor disease management of the floating patients, the potential threat brought by the diabetes in floating population is imponderable. The government should establish the national surveillance system of diabetes for the floating population, strengthen the construction of the primary medical institutions, and optimize the existing funding system.

78 FR 48912 - Agency Information Collection Activities: Submission to OMB for Reinstatement, With, of a...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-12

... for analysis in the NCUA Low-Income Designation (LID) Tool. The LID Tool is a geocoding software... the member address data are obtained through the examination process and the results of the LID Tool... may send an electronic member address data file for analysis in the LID Tool. If a credit union does...

78 FR 59377 - Agency Information Collection Activities: Submission to OMB for Reinstatement, With Change, of a...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-26

... analysis in the NCUA Low-Income Designation (LID) Tool. The LID Tool is a geocoding software program which... data are obtained through the examination process and the results of the LID Tool indicate the credit... electronic member address data file for analysis in the LID Tool. If a credit union does not qualify for a...

With a flick of the lid: a novel trapping mechanism in Nepenthes gracilis pitcher plants.

PubMed

Bauer, Ulrike; Di Giusto, Bruno; Skepper, Jeremy; Grafe, T Ulmar; Federle, Walter

2012-01-01

Carnivorous pitcher plants capture prey with modified leaves (pitchers), using diverse mechanisms such as 'insect aquaplaning' on the wet pitcher rim, slippery wax crystals on the inner pitcher wall, and viscoelastic retentive fluids. Here we describe a new trapping mechanism for Nepenthes gracilis which has evolved a unique, semi-slippery wax crystal surface on the underside of the pitcher lid and utilises the impact of rain drops to 'flick' insects into the trap. Depending on the experimental conditions (simulated 'rain', wet after 'rain', or dry), insects were captured mainly by the lid, the peristome, or the inner pitcher wall, respectively. The application of an anti-slip coating to the lower lid surface reduced prey capture in the field. Compared to sympatric N. rafflesiana, N. gracilis pitchers secreted more nectar under the lid and less on the peristome, thereby directing prey mainly towards the lid. The direct contribution to prey capture represents a novel function of the pitcher lid.

With a Flick of the Lid: A Novel Trapping Mechanism in Nepenthes gracilis Pitcher Plants

PubMed Central

Bauer, Ulrike; Di Giusto, Bruno; Skepper, Jeremy; Grafe, T. Ulmar; Federle, Walter

2012-01-01

Carnivorous pitcher plants capture prey with modified leaves (pitchers), using diverse mechanisms such as ‘insect aquaplaning’ on the wet pitcher rim, slippery wax crystals on the inner pitcher wall, and viscoelastic retentive fluids. Here we describe a new trapping mechanism for Nepenthes gracilis which has evolved a unique, semi-slippery wax crystal surface on the underside of the pitcher lid and utilises the impact of rain drops to ‘flick’ insects into the trap. Depending on the experimental conditions (simulated ‘rain’, wet after ‘rain’, or dry), insects were captured mainly by the lid, the peristome, or the inner pitcher wall, respectively. The application of an anti-slip coating to the lower lid surface reduced prey capture in the field. Compared to sympatric N. rafflesiana, N. gracilis pitchers secreted more nectar under the lid and less on the peristome, thereby directing prey mainly towards the lid. The direct contribution to prey capture represents a novel function of the pitcher lid. PMID:22719998

The devil is in the details: comparison between COP9 signalosome (CSN) and the LID of the 26S proteasome.

PubMed

Meister, Cindy; Gulko, Miriam Kolog; Köhler, Anna M; Braus, Gerhard H

2016-02-01

The COP9 signalosome (CSN) and the proteasomal LID are conserved macromolecular complexes composed of at least eight subunits with molecular weights of approximately 350 kDa. CSN and LID are part of the ubiquitin–proteasome pathway and cleave isopeptide linkages of lysine side chains on target proteins. CSN cleaves the isopeptide bond of ubiquitin-like protein Nedd8 from cullins, whereas the LID cleaves ubiquitin from target proteins sentenced for degradation. CSN and LID are structurally and functionally similar but the order of the assembly pathway seems to be different. The assembly differs in at least the last subunit joining the pre-assembled subcomplex. This review addresses the similarities and differences in structure, function and assembly of CSN and LID.

[Advances in low impact development technology for urban stormwater management].

PubMed

Liu, Wen; Chen, Wei-ping; Peng, Chi

2015-06-01

Low impact development ( LID), as an innovative technology for stormwater management, is effective to mitigate urban flooding and to detain pollutants. This paper systemically introduced the LID technology system, and summarized the reduction effects of three typical LID facilities (i.e. , bio-retention, green roof and permeable pavement) on stormwater runoff and main pollutants in recent literature, as well as research outcomes and experiences of LID technology on model simulation, cost-benefit analysis and management system. On this basis, we analyzed the problems and limitations of current LID technology studies. Finally, some suggestions about future research directions, appropriate design and scientific management were put forth. This work intended to provide scientific basis and suggestions for widespread use and standard setting of LID technology in China by referencing overseas studies.

Hydraulic characteristics of low-impact development practices in northeastern Ohio, 2008–2010

USGS Publications Warehouse

Darner, Robert A.; Dumouchelle, Denise H.

2011-01-01

Low-impact development (LID) is an approach to managing stormwater as near to its source as possible; this is accomplished by minimizing impervious surfaces and promoting more natural infiltration and evapotranspiration than is typically associated with developed areas. Two newly constructed LID sites in northeastern Ohio were studied to document their hydraulic characteristics. A roadside best-management practice (BMP) was constructed by replacing about 1,400 linear feet of existing ditches with a bioswale/rain garden BMP consisting of a grassed swale interspersed with rain-garden/overflow structures. The site was monitored in 2008, 2009, and 2010. Although some overflows occurred, numerous precipitation events exceeding the 0.75-inch design storm did not result in overflows. A second study site consists of an 8,200-square-foot parking lot made of a pervious pavers and a rain garden that receives runoff from the roof of a nearby commercial building. A comparison of data from 2009 and 2010 indicates that the median runoff volume in 2010 decreased relative to 2009. The centroid lag times (time difference between centroid of precipitation and centroid of flow) decreased in 2010, most likely due to more intense, shorter duration precipitation events and maturation of the rain garden. Additional data could help quantify the relation between meteorological variables and BMP efficiency.

Detector development for Jefferson Lab's 12GeV Upgrade

DOE PAGES

Qiang, Yi

2015-05-01

Jefferson Lab will soon finish its highly anticipated 12 GeV Upgrade. With doubled maximum energy, Jefferson Lab’s Continuous Electron Beam Accelerator Facility (CEBAF) will enable a new experimental program with substantial discovery potential, addressing important topics in nuclear, hadronic and electroweak physics. In order to take full advantage of the high energy, high luminosity beam, new detectors are being developed, designed and constructed to fit the needs of different physics topics. The paper will give an overview of various new detector technologies to be used for 12 GeV experiments. It will then focus on the development of two solenoid-based spectrometers,more » the GlueX and SoLID spectrometers. The GlueX experiment in Hall D will study the complex properties of gluons through exotic hybrid meson spectroscopy. The GlueX spectrometer, a hermetic detector package designed for spectroscopy and the associated partial wave analysis, is currently in the final stage of construction. Hall A, on the other hand, is developing the SoLID spectrometer to capture the 3D image of the nucleon from semi-inclusive processes and to study the intrinsic properties of quarks through mirror symmetry breaking. Such a spectrometer will have the capability to handle very high event rates while still maintaining a large acceptance in the forward region.« less

Deiodinase activities in thyroids and tissues of iodine-deficient female rats.

PubMed

Lavado-Autric, Rosalia; Calvo, Rosa Maria; de Mena, Raquel Martinez; de Escobar, Gabriella Morreale; Obregon, Maria-Jesus

2013-01-01

Severe iodine deficiency is characterized by goiter, preferential synthesis, and secretion of T(3) in thyroids, hypothyroxinemia in plasma and tissues, normal or low plasma T(3), and slightly increased plasma TSH. We studied changes in deiodinase activities and mRNA in several tissues of rats maintained on low-iodine diets (LIDs) or LIDs supplemented with iodine (LID+I). T(4) and T(3) concentrations decreased in plasma, tissues, and thyroids of LID rats, and T(4) decreased more than T(3) (50%). The highest type 1 iodothyronine deiodinase (D1) activities were found in the thyroid, kidney, and the liver; pituitary, lung, and ovary had lower D1 activities; but the lowest levels were found in the heart and skeletal muscle. D1 activity decreased in all tissues of LID rats (10-40% of LID+I rats), except for ovary and thyroids, which D1 activity increased 2.5-fold. Maximal type 2 iodothyronine deiodinase (D2) activities were found in thyroid, brown adipose tissue, and pituitary, increasing 6.5-fold in thyroids of LID rats and about 20-fold in the whole gland. D2 always increased in response to LID, and maximal increases were found in the cerebral cortex (19-fold), thyroid, brown adipose tissue, and pituitary (6-fold). Lower D2 activities were found in the ovary, heart, and adrenal gland, which increased in LID. Type 3 iodothyronine deiodinase activity was undetectable. Thyroidal Dio1 and Dio2 mRNA increased in the LID rats, and Dio1 decreased in the lung, with no changes in mRNA expression in other tissues. Our data indicate that LID induces changes in deiodinase activities, especially in the thyroid, to counteract the low T(4) synthesis and secretion, contributing to maintain the local T(3) concentrations in the tissues with D2 activity.

Spoken language identification based on the enhanced self-adjusting extreme learning machine approach.

PubMed

Albadr, Musatafa Abbas Abbood; Tiun, Sabrina; Al-Dhief, Fahad Taha; Sammour, Mahmoud A M

2018-01-01

Spoken Language Identification (LID) is the process of determining and classifying natural language from a given content and dataset. Typically, data must be processed to extract useful features to perform LID. The extracting features for LID, based on literature, is a mature process where the standard features for LID have already been developed using Mel-Frequency Cepstral Coefficients (MFCC), Shifted Delta Cepstral (SDC), the Gaussian Mixture Model (GMM) and ending with the i-vector based framework. However, the process of learning based on extract features remains to be improved (i.e. optimised) to capture all embedded knowledge on the extracted features. The Extreme Learning Machine (ELM) is an effective learning model used to perform classification and regression analysis and is extremely useful to train a single hidden layer neural network. Nevertheless, the learning process of this model is not entirely effective (i.e. optimised) due to the random selection of weights within the input hidden layer. In this study, the ELM is selected as a learning model for LID based on standard feature extraction. One of the optimisation approaches of ELM, the Self-Adjusting Extreme Learning Machine (SA-ELM) is selected as the benchmark and improved by altering the selection phase of the optimisation process. The selection process is performed incorporating both the Split-Ratio and K-Tournament methods, the improved SA-ELM is named Enhanced Self-Adjusting Extreme Learning Machine (ESA-ELM). The results are generated based on LID with the datasets created from eight different languages. The results of the study showed excellent superiority relating to the performance of the Enhanced Self-Adjusting Extreme Learning Machine LID (ESA-ELM LID) compared with the SA-ELM LID, with ESA-ELM LID achieving an accuracy of 96.25%, as compared to the accuracy of SA-ELM LID of only 95.00%.

Spoken language identification based on the enhanced self-adjusting extreme learning machine approach

PubMed Central

Tiun, Sabrina; AL-Dhief, Fahad Taha; Sammour, Mahmoud A. M.

2018-01-01

Spoken Language Identification (LID) is the process of determining and classifying natural language from a given content and dataset. Typically, data must be processed to extract useful features to perform LID. The extracting features for LID, based on literature, is a mature process where the standard features for LID have already been developed using Mel-Frequency Cepstral Coefficients (MFCC), Shifted Delta Cepstral (SDC), the Gaussian Mixture Model (GMM) and ending with the i-vector based framework. However, the process of learning based on extract features remains to be improved (i.e. optimised) to capture all embedded knowledge on the extracted features. The Extreme Learning Machine (ELM) is an effective learning model used to perform classification and regression analysis and is extremely useful to train a single hidden layer neural network. Nevertheless, the learning process of this model is not entirely effective (i.e. optimised) due to the random selection of weights within the input hidden layer. In this study, the ELM is selected as a learning model for LID based on standard feature extraction. One of the optimisation approaches of ELM, the Self-Adjusting Extreme Learning Machine (SA-ELM) is selected as the benchmark and improved by altering the selection phase of the optimisation process. The selection process is performed incorporating both the Split-Ratio and K-Tournament methods, the improved SA-ELM is named Enhanced Self-Adjusting Extreme Learning Machine (ESA-ELM). The results are generated based on LID with the datasets created from eight different languages. The results of the study showed excellent superiority relating to the performance of the Enhanced Self-Adjusting Extreme Learning Machine LID (ESA-ELM LID) compared with the SA-ELM LID, with ESA-ELM LID achieving an accuracy of 96.25%, as compared to the accuracy of SA-ELM LID of only 95.00%. PMID:29672546

U.S. Senate examines concerns about marine debris from 2011 Japan tsunami

NASA Astrophysics Data System (ADS)

Showstack, Randy

2012-05-01

Approximately 5 million tons of debris washed into the Pacific Ocean from Japan following the 11 March 2011 tsunami, and the Japanese government estimates that 1.5 million tons may still be floating on or below the ocean surface. However, it is not known how much debris may reach U.S. shores, an official from the National Oceanic and Atmospheric Administration (NOAA) testified at a 17 May Senate hearing. "If you've got 1.5 [million tons] that's floating and you leave it in there for a year, how much of that is still going be floating and available to come ashore? We don't have a clue," David Kennedy, NOAA assistant administrator for ocean services and coastal zone management, testified before a subcommittee of the Senate Committee on Commerce, Science, and Transportation. He said that some materials pushed by the wind could be expected to float but that materials pushed by currents under the surface are difficult to find. "A whole bunch of the 1.5 million is construction debris, and do [wooden] two-by-fours still float after a year? We're not sure."

Development of Dimensionless Index Assessing Low Impact Development in Urban Areas

NASA Astrophysics Data System (ADS)

Jun, S. H.; Lee, E. H.; Kim, J. H.

2017-12-01

Because the rapid urbanization and industrialization have increased the impervious area of watersheds, inundation in urban area and water pollution of river by non-point pollutants have caused serious problems for a long time. Low Impact Development (LID) techniques have been implemented for the solution of these problems due to its cost effectiveness for mitigating the water quality and quantity impact on urban areas. There have been many studies about the effectiveness of LID, but there is a lack of research on developing an index for the assessment of LID performance. In this study, the dimensionless reliability index of LID is proposed. The index is developed using Distance Measure Method (DMM). DMM is used to consider the parameters that have different units. The parameters for reliability of LID are the amount of pollutant at the outfall and the flooding volume. Both parameters become dimensionless index by DMM. Weighted factors in dimensionless index are considered to realize the behavior of reliability for the variation of importance to the parameters. LID is applied to an actual area called Gasan city in Seoul, South Korea where inundation is frequently occurred. The reliability is estimated for 16 different rainfall events. For each rainfall event, the parameters with LID installation are compared with those of no LID installation. Depending on which parameter is considered more important, the results showed difference. In conclusion, the optimal locations of LID are suggested as the weighted factors change.

Maintaining Microclimates during Nanoliter Chemical Dispensations Using Custom-Designed Source Plate Lids.

PubMed

Foley, Bryan J; Drozd, Ashley M; Bollard, Mary T; Laspina, Denise; Podobedov, Nikita; Zeniou, Nicholas; Rao, Anjali S; Andi, Babak; Jackimowicz, Rick; Sweet, Robert M; McSweeney, Sean; Soares, Alexei S

2016-02-01

A method is described for using custom snap-on lids to protect chemicals in microtiter plates from evaporation and contamination. The lids contain apertures (diameter 1.5, 1.0, or 0.5 mm) through which the chemical building blocks can be transferred. The lid with 0.5 mm apertures was tested using a noncontact acoustic liquid handler; the 1.0 and 1.5 mm lids were tested using two tip-based liquid handlers. All of the lids reduced the rate at which solvents evaporated to room air, and greatly reduced the rate of contamination by water and oxygen from room air. In steady-state measurements, the lids reduced the rate of evaporation of methanol, 1-hexene, and water by 33% to 248%. In cycled experiments, the contamination of aqueous solvent with oxygen was reduced below detectability and the rate at which DMSO engorged atmospheric water was reduced by 81%. Our results demonstrate that the lids preserve the integrity of air-sensitive reagents during the time needed for different types of liquid handlers to perform dispensations. Controlling degradation and evaporation of chemical building blocks exposed to the atmosphere is increasingly useful as the reagent volume is reduced by advances in liquid handling technology, such as acoustic droplet ejection. © 2015 Society for Laboratory Automation and Screening.

Optimizing low impact development (LID) for stormwater runoff treatment in urban area, Korea: Experimental and modeling approach.

PubMed

Baek, Sang-Soo; Choi, Dong-Ho; Jung, Jae-Woon; Lee, Hyung-Jin; Lee, Hyuk; Yoon, Kwang-Sik; Cho, Kyung Hwa

2015-12-01

Currently, continued urbanization and development result in an increase of impervious areas and surface runoff including pollutants. Also one of the greatest issues in pollutant emissions is the first flush effect (FFE), which implies a greater discharge rate of pollutant mass in the early part in the storm. Low impact development (LID) practices have been mentioned as a promising strategy to control urban stormwater runoff and pollution in the urban ecosystem. However, this requires many experimental and modeling efforts to test LID characteristics and propose an adequate guideline for optimizing LID management. In this study, we propose a novel methodology to optimize the sizes of different types of LID by conducting intensive stormwater monitoring and numerical modeling in a commercial site in Korea. The methodology proposed optimizes LID size in an attempt to moderate FFE on a receiving waterbody. Thereby, the main objective of the optimization is to minimize mass first flush (MFF), which is an indicator for quantifying FFE. The optimal sizes of 6 different LIDs ranged from 1.2 mm to 3.0 mm in terms of runoff depths, which significantly moderate the FFE. We hope that the new proposed methodology can be instructive for establishing LID strategies to mitigate FFE. Copyright © 2015 Elsevier Ltd. All rights reserved.

152. Photographic copy of original construction drawing dated October 24, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

152. Photographic copy of original construction drawing dated October 24, 1930 (from Record Group 115, Denver Branch of the National Archives, Denver). 60 x 12 RING GATE CONTROL; FLOAT WELL ASSEMBLY AND COVER HOIST STEM-CONNECTION ROD-SLEEVE. - Owyhee Dam, Across Owyhee River, Nyssa, Malheur County, OR

Association of a neuronal nitric oxide synthase gene polymorphism with levodopa-induced dyskinesia in Parkinson's disease.

PubMed

Santos-Lobato, Bruno Lopes; Borges, Vanderci; Ferraz, Henrique Ballalai; Mata, Ignacio Fernandez; Zabetian, Cyrus P; Tumas, Vitor

2018-04-01

Levodopa-induced dyskinesia (LID) is a common complication of advanced Parkinson's disease (PD). PD physiopathology is associated with dopaminergic and non-dopaminergic pathways, including the nitric oxide system. The present study aims to examine the association of a neuronal nitric oxide synthase gene (NOS1) single nucleotide polymorphism (rs2682826) with LID in PD patients. We studied 186 PD patients using levodopa. The presence of LID was defined as a MDS-UPDRS Part IV score ≥1 on item 4.1. We tested for association between NOS1 rs2682826 and the presence, daily frequency, and functional impact of LID using regression models, adjusting for important covariates. There was no significant association between genotype and any of the LID-related variables examined. Our results suggest that this NOS1 polymorphism does not contribute to LID susceptibility or severity. However, additional studies that include a comprehensive set of NOS1 variants will be needed to fully define the role of this gene in LID. Copyright © 2017 Elsevier Inc. All rights reserved.

Optimal trajectory planning of free-floating space manipulator using differential evolution algorithm

NASA Astrophysics Data System (ADS)

Wang, Mingming; Luo, Jianjun; Fang, Jing; Yuan, Jianping

2018-03-01

The existence of the path dependent dynamic singularities limits the volume of available workspace of free-floating space robot and induces enormous joint velocities when such singularities are met. In order to overcome this demerit, this paper presents an optimal joint trajectory planning method using forward kinematics equations of free-floating space robot, while joint motion laws are delineated with application of the concept of reaction null-space. Bézier curve, in conjunction with the null-space column vectors, are applied to describe the joint trajectories. Considering the forward kinematics equations of the free-floating space robot, the trajectory planning issue is consequently transferred to an optimization issue while the control points to construct the Bézier curve are the design variables. A constrained differential evolution (DE) scheme with premature handling strategy is implemented to find the optimal solution of the design variables while specific objectives and imposed constraints are satisfied. Differ from traditional methods, we synthesize null-space and specialized curve to provide a novel viewpoint for trajectory planning of free-floating space robot. Simulation results are presented for trajectory planning of 7 degree-of-freedom (DOF) kinematically redundant manipulator mounted on a free-floating spacecraft and demonstrate the feasibility and effectiveness of the proposed method.

Life cycle implications of urban green infrastructure.

PubMed

Spatari, Sabrina; Yu, Ziwen; Montalto, Franco A

2011-01-01

Low Impact Development (LID) is part of a new paradigm in urban water management that aims to decentralize water storage and movement functions within urban watersheds. LID strategies can restore ecosystem functions and reduce runoff loadings to municipal water pollution control facilities (WPCF). This research examines the avoided energy and greenhouse gas (GHG) emissions of select LID strategies using life cycle assessment (LCA) and a stochastic urban watershed model. We estimate annual energy savings and avoided GHG emissions of 7.3 GJ and 0.4 metric tons, respectively, for a LID strategy implemented in a neighborhood in New York City. Annual savings are small compared to the energy and GHG intensity of the LID materials, resulting in slow environmental payback times. This preliminary analysis suggests that if implemented throughout an urban watershed, LID strategies may have important energy cost savings to WPCF, and can make progress towards reducing their carbon footprint. Copyright © 2011 Elsevier Ltd. All rights reserved.

Safinamide reduces dyskinesias and prolongs L-DOPA antiparkinsonian effect in parkinsonian monkeys.

PubMed

Grégoire, Laurent; Jourdain, Vincent A; Townsend, Matthew; Roach, Arthur; Di Paolo, Thérèse

2013-05-01

Safinamide is a compound under investigation for use in the treatment of Parkinson's disease for combination with pharmacological therapy currently available. The objective of this study was to test the effects of safinamide in an animal model of l-DOPA-induced dyskinesias (LID), the MPTP lesioned dyskinetic macaque monkey, in comparison to and in combination with amantadine. LID and parkinsonian symptoms were measured in dyskinetic monkeys treated with l-DOPA with and without several dose levels of safinamide, amantadine, and the two in combination. Safinamide plasma levels were monitored during the experiments. Safinamide pre-treatment (3, 10, 20 and 30 mg/kg) dose-dependently reduced LID scores, in two acute and one semi-chronic experiment. Intensity and duration of LID were reduced and inversely correlated with safinamide blood levels. All doses of safinamide tested prolonged the duration of the beneficial antiparkinsonian effect of l-DOPA. Amantadine (5 and 20 mg/kg) reduced LID, but reduced duration of antiparkinsonian response to l-DOPA. When added to amantadine (5 mg/kg), safinamide showed no (3 mg/kg) or modest (20 mg/kg) additional beneficial effects on LID while the combined treatment prevented the reduction of the duration of the l-DOPA antiparkinsonian effect observed with amantadine only. Safinamide and amantadine reduced LID in this primate model while only safinamide increased the duration of the antiparkinsonian response of l-DOPA, suggesting that safinamide may have effects on LID that are pharmacologically distinct from amantadine, which is in current clinical use for control of LID. Copyright © 2013 Elsevier Ltd. All rights reserved.

Low vibration laboratory with a single-stage vibration isolation for microscopy applications.

PubMed

Voigtländer, Bert; Coenen, Peter; Cherepanov, Vasily; Borgens, Peter; Duden, Thomas; Tautz, F Stefan

2017-02-01

The construction and the vibrational performance of a low vibration laboratory for microscopy applications comprising a 100 ton floating foundation supported by passive pneumatic isolators (air springs), which rest themselves on a 200 ton solid base plate, are discussed. The optimization of the air spring system leads to a vibration level on the floating floor below that induced by an acceleration of 10 ng for most frequencies. Additional acoustic and electromagnetic isolation is accomplished by a room-in-room concept.

An integrated circuit floating point accumulator

NASA Technical Reports Server (NTRS)

Goldsmith, T. C.

1977-01-01

Goddard Space Flight Center has developed a large scale integrated circuit (type 623) which can perform pulse counting, storage, floating point compression, and serial transmission, using a single monolithic device. Counts of 27 or 19 bits can be converted to transmitted values of 12 or 8 bits respectively. Use of the 623 has resulted in substantial savaings in weight, volume, and dollar resources on at least 11 scientific instruments to be flown on 4 NASA spacecraft. The design, construction, and application of the 623 are described.

Simulating Molecular Mechanisms of the MDM2-Mediated Regulatory Interactions: A Conformational Selection Model of the MDM2 Lid Dynamics

PubMed Central

Verkhivker, Gennady M.

2012-01-01

Diversity and complexity of MDM2 mechanisms govern its principal function as the cellular antagonist of the p53 tumor suppressor. Structural and biophysical studies have demonstrated that MDM2 binding could be regulated by the dynamics of a pseudo-substrate lid motif. However, these experiments and subsequent computational studies have produced conflicting mechanistic models of MDM2 function and dynamics. We propose a unifying conformational selection model that can reconcile experimental findings and reveal a fundamental role of the lid as a dynamic regulator of MDM2-mediated binding. In this work, structure, dynamics and energetics of apo-MDM2 are studied as a function of posttranslational modifications and length of the lid. We found that the dynamic equilibrium between “closed” and “semi-closed” lid forms may be a fundamental characteristic of MDM2 regulatory interactions, which can be modulated by phosphorylation, phosphomimetic mutation as well as by the lid size. Our results revealed that these factors may regulate p53-MDM2 binding by fine-tuning the thermodynamic equilibrium between preexisting conformational states of apo-MDM2. In agreement with NMR studies, the effect of phosphorylation on MDM2 interactions was more pronounced with the truncated lid variant that favored the thermodynamically dominant closed form. The phosphomimetic mutation S17D may alter the lid dynamics by shifting the thermodynamic equilibrium towards the ensemble of “semi-closed” conformations. The dominant “semi-closed” lid form and weakened dependence on the phosphorylation seen in simulations with the complete lid can provide a rationale for binding of small p53-based mimetics and inhibitors without a direct competition with the lid dynamics. The results suggested that a conformational selection model of preexisting MDM2 states may provide a robust theoretical framework for understanding MDM2 dynamics. Probing biological functions and mechanisms of MDM2 regulation would require further integration of computational and experimental studies and may help to guide drug design of novel anti-cancer therapeutics. PMID:22815859

Wireless telemetry system for floating bodies

NASA Technical Reports Server (NTRS)

Fain, L. T.; Cribb, H. E.

1974-01-01

Unit includes rugged waterproof cables and equipment containers, low power, sturdy antenna construction, and easy equipment setup and serviceability. Accuracy and reliability of entire measurement system were not sacrificed.

Green Infrastructure and Watershed-Scale Hydrology in a Mixed Land Cover System

NASA Astrophysics Data System (ADS)

Hoghooghi, N.; Golden, H. E.; Bledsoe, B. P.

2017-12-01

Urbanization results in replacement of pervious areas (e.g., vegetation, topsoil) with impervious surfaces such as roads, roofs, and parking lots, which cause reductions in interception, evapotranspiration, and infiltration, and increases in surface runoff (overland flow) and pollutant loads and concentrations. Research on the effectiveness of different Green Infrastructure (GI), or Low Impact Development (LID), practices to reduce these negative impacts on stream flow and water quality has been mostly focused at the local scale (e.g., plots, small catchments). However, limited research has considered the broader-scale effects of LID, such as how LID practices influence water quantity, nutrient removal, and aquatic ecosystems at watershed scales, particularly in mixed land cover and land use systems. We use the Visualizing Ecosystem Land Management Assessments (VELMA) model to evaluate the effects of different LID practices on daily and long-term watershed-scale hydrology, including infiltration surface runoff. We focus on Shayler Crossing (SHC) watershed, a mixed land cover (61% urban, 24% agriculture, 15% forest) subwatershed of the East Fork Little Miami River watershed, Ohio, United States, with a drainage area of 0.94 km2. The model was calibrated to daily stream flow at the outlet of SHC watershed from 2009 to 2010 and was applied to evaluate diverse distributions (at 25% to 100% implementation levels) and types (e.g., pervious pavement and rain gardens) of LID across the watershed. Results show reduced surface water runoff and higher rates of infiltration concomitant with increasing LID implementation levels; however, this response varies between different LID practices. The highest magnitude response in streamflow at the watershed outlet is evident when a combination of LID practices is applied. The combined scenarios elucidate that the diverse watershed-scale hydrological responses of LID practices depend primarily on the type and extent of the implemented practices. Our work provides a key advancement toward improving current understanding of the effectiveness and efficiencies of LID approaches in mixed land cover watersheds.

29 CFR 1926.1441 - Equipment with a rated hoisting/lifting capacity of 2,000 pounds or less.

Code of Federal Regulations, 2011 CFR

2011-07-01

... CONSTRUCTION Cranes and Derricks in Construction § 1926.1441 Equipment with a rated hoisting/lifting capacity... crane/derrick lifts—supplemental requirements); § 1926.1434 (Equipment modifications); § 1926.1435 (Tower cranes); § 1926.1436 (Derricks); § 1926.1437 (Floating cranes/derricks and land cranes/derricks on...

Pay As You Go: A Better Way of Funding School Construction.

ERIC Educational Resources Information Center

Carey, Kelley D.

2000-01-01

Pay-as-you-go funding (via local option sales taxes or earmarked property taxes) is superior to floating expensive bond issues to resolve school construction crises. Districts can plan projects more thoughtfully, focus on project priorities, avoid arbitrage problems and high insurance costs, and address socioeconomic considerations more equitably.…

FRAMEWORK FOR PLACEMENT OF BMP/LID IN URBAN WATERSHEDS

EPA Science Inventory

To assist stormwater management professionals in planning for BMP/LID implementation, the U.S. Environmental Protection Agency (USEPA) has funded the development of a decision support system for selection and placement of BMP/LID at strategic locations in urban watersheds. The...

Lid design for low level waste container

DOEpatents

Holbrook, R.H.; Keener, W.E.

1995-02-28

A container for low level waste includes a shell and a lid. The lid has a frame to which a planar member is welded. The lid frame includes a rectangular outer portion made of square metal tubing, a longitudinal beam extending between axial ends of the rectangular outer portion, and a transverse beam extending between opposite lateral sides of the rectangular outer portion. Two pairs of diagonal braces extend between the longitudinal beam and the four corners of the rectangular outer portion of the frame. 6 figs.

Lid design for low level waste container

DOEpatents

Holbrook, Richard H.; Keener, Wendell E.

1995-01-01

A container for low level waste includes a shell and a lid. The lid has a frame to which a planar member is welded. The lid frame includes a rectangular outer portion made of square metal tubing, a longitudinal beam extending between axial ends of the rectangular outer portion, and a transverse beam extending between opposite lateral sides of the rectangular outer portion. Two pairs of diagonal braces extend between the longitudinal beam and the four corners of the rectangular outer portion of the frame.

Results from a round robin test for the ecotoxicological evaluation of construction products using two leaching tests and an aquatic test battery.

PubMed

Gartiser, Stefan; Heisterkamp, Ines; Schoknecht, Ute; Burkhardt, Michael; Ratte, Monika; Ilvonen, Outi; Brauer, Frank; Brückmann, Jan; Dabrunz, André; Egeler, Philipp; Eisl, Andrea-Maria; Feiler, Ute; Fritz, Ines; König, Sabina; Lebertz, Herbert; Pandard, Pascal; Pötschke, Gabriele; Scheerbaum, Dirk; Schreiber, Frank; Soldán, Přemysl; Weiß, Roland; Weltens, Reinhilde

2017-05-01

A European round robin test according to ISO 5725-2 was conceptually prepared, realised, and evaluated. The aim was to determine the inter-laboratory variability of the overall process for the ecotoxicological characterization of construction products in eluates and bioassays. To this end, two construction products BAM-G1 (granulate) and HSR-2 (roof sealing sheet), both made of EPDM polymers (rubber), were selected. The granular construction product was eluted in a one stage batch test, the planar product in the Dynamic Surface Leaching test (DSLT). A total of 17 laboratories from 5 countries participated in the round robin test: Germany (12), Austria (2), Belgium (1), Czech Republic (1) and France (1). A test battery of four standardised ecotoxicity tests with algae, daphnia, luminescent bacteria and zebrafish eggs was used. As toxicity measures, EC50 and LID values were calculated. All tests, except the fish egg test, were basically able to demonstrate toxic effects and the level of toxicity. The reproducibility of test results depended on the test specimens and the test organisms. Generally, the variability of the EC50 or LID values increased with the overall level of toxicity. For the very toxic BAM-G1 eluate a relative high variability of CV = 73%-110% was observed for EC50 in all biotests, while for the less toxic HSR-2 eluate the reproducibility of EC50 varied with sensitivity: it was very good (CV = 9.3%) for the daphnia test with the lowest sensitivity, followed by the algae test (CV = 36.4%). The luminescent bacteria test, being the most sensitive bioassay for HSR-2 Eluate, showed the highest variability (CV = 74.8%). When considering the complex overall process the reproducibility of bioassays with eluates from construction products was acceptable. Copyright © 2017. Published by Elsevier Ltd.

Hydroponic root mats for wastewater treatment-a review.

PubMed

Chen, Zhongbing; Cuervo, Diego Paredes; Müller, Jochen A; Wiessner, Arndt; Köser, Heinz; Vymazal, Jan; Kästner, Matthias; Kuschk, Peter

2016-08-01

Hydroponic root mats (HRMs) are ecotechnological wastewater treatment systems where aquatic vegetation forms buoyant filters by their dense interwoven roots and rhizomes, sometimes supported by rafts or other floating materials. A preferential hydraulic flow is created in the water zone between the plant root mat and the bottom of the treatment system. When the mat touches the bottom of the water body, such systems can also function as HRM filter; i.e. the hydraulic flow passes directly through the root zone. HRMs have been used for the treatment of various types of polluted water, including domestic wastewater; agricultural effluents; and polluted river, lake, stormwater and groundwater and even acid mine drainage. This article provides an overview on the concept of applying floating HRM and non-floating HRM filters for wastewater treatment. Exemplary performance data are presented, and the advantages and disadvantages of this technology are discussed in comparison to those of ponds, free-floating plant and soil-based constructed wetlands. Finally, suggestions are provided on the preferred scope of application of HRMs.

Study on design method and vibration reduction characteristic of floating raft with periodic structure

NASA Astrophysics Data System (ADS)

Fang, Yuanyuan; Zuo, Yanyan; Xia, Zhaowang

2018-03-01

The noise level is getting higher with the development of high-power marine power plant. Mechanical noise is one of the most obvious noise sources which not only affect equipment reliability, riding comfort and working environment, but also enlarge underwater noise. The periodic truss type device which is commonly applied in fields of aerospace and architectural is introduced to floating raft construction in ship. Four different raft frame structure are designed in the paper. The vibration transmissibility is taken as an evaluation index to measure vibration isolation effect. A design scheme with the best vibration isolation effect is found by numerical method. Plate type and the optimized periodic truss type raft frame structure are processed to experimental verify vibration isolation effect of the structure of the periodic raft. The experimental results demonstrate that the same quality of the periodic truss floating raft has better isolation effect than that of the plate type floating raft.

Experimental Study on New Multi-Column Tension-Leg-Type Floating Wind Turbine

NASA Astrophysics Data System (ADS)

Zhao, Yong-sheng; She, Xiao-he; He, Yan-ping; Yang, Jian-min; Peng, Tao; Kou, Yu-feng

2018-04-01

Deep-water regions often have winds favorable for offshore wind turbines, and floating turbines currently show the greatest potential to exploit such winds. This work established proper scaling laws for model tests, which were then implemented in the construction of a model wind turbine with optimally designed blades. The aerodynamic, hydrodynamic, and elastic characteristics of the proposed new multi-column tension-leg-type floating wind turbine (WindStar TLP system) were explored in the wave tank testing of a 1:50 scale model at the State Key Laboratory of Ocean Engineering at Shanghai Jiao Tong University. Tests were conducted under conditions of still water, white noise waves, irregular waves, and combined wind, wave, and current loads. The results established the natural periods of the motion, damping, motion response amplitude operators, and tendon tensions of the WindStar TLP system under different environmental conditions, and thus could serve as a reference for further research. Key words: floating wind turbine, model test, WindStar TLP, dynamic response

The lid wiper and muco-cutaneous junction anatomy of the human eyelid margins: an in vivo confocal and histological study

PubMed Central

Knop, Erich; Knop, Nadja; Zhivov, Andrey; Kraak, Robert; Korb, Donald R; Blackie, Caroline; Greiner, Jack V; Guthoff, Rudolf

2011-01-01

The inner border of the eyelid margin is critically important for ocular surface integrity because it guarantees the thin spread of the tear film. Its exact morphology in the human is still insufficiently known. The histology in serial sections of upper and lower lid margins in whole-mount specimens from 10 human body donors was compared to in vivo confocal microscopy of eight eyes with a Heidelberg retina-tomograph (HRT II) and attached Rostock cornea module. Behind the posterior margin of the Meibomian orifices, the cornified epidermis stopped abruptly and was replaced by a continuous layer of para-keratinized (pk) cells followed by discontinuous pk cells. The pk cells covered the muco-cutaneous junction (MCJ), the surface of which corresponded to the line of Marx (0.2–0.3 mm wide). Then a stratified epithelium with a conjunctival structure of cuboidal cells, some pk cells, and goblet cells formed an epithelial elevation of typically about 100 μm initial thickness (lid wiper). This continued for 0.3–1.5 mm and formed a slope. The MCJ and lid wiper extended all along the lid margin from nasal to temporal positions in the upper and lower lids. Details of the epithelium and connective tissue were also detectable using the Rostock cornea module. The human inner lid border has distinct zones. Due to its location and morphology, the epithelial lip of the lid wiper appears a suitable structure to spread the tear film and is distinct from the MCJ/line of Marx. Better knowledge of the lid margin appears important for understanding dry eye disease and its morphology can be analysed clinically by in vivo confocal microscopy. PMID:21413985

Nicotine-mediated improvement in L-dopa-induced dyskinesias in MPTP-lesioned monkeys is dependent on dopamine nerve terminal function.

PubMed

Quik, Maryka; Mallela, Archana; Chin, Matthew; McIntosh, J Michael; Perez, Xiomara A; Bordia, Tanuja

2013-02-01

L-dopa-induced dyskinesias (LIDs) are abnormal involuntary movements that develop with long term L-dopa therapy for Parkinson's disease. Studies show that nicotine administration reduced LIDs in several parkinsonian animal models. The present work was done to understand the factors that regulate the nicotine-mediated reduction in LIDs in MPTP-lesioned nonhuman primates. To approach this, we used two groups of monkeys, one with mild-moderate and the other with more severe parkinsonism rendered dyskinetic using L-dopa. In mild-moderately parkinsonian monkeys, nicotine pretreatment (300 μg/ml via drinking water) prevented the development of LIDs by ~75%. This improvement was maintained when the nicotine dose was lowered to 50 μg/ml but was lost with nicotine removal. Nicotine re-exposure again decreased LIDs. By contrast, nicotine treatment did not reduce LIDs in monkeys with more severe parkinsonism. We next determined how nicotine's ability to reduce LIDs correlated with lesion-induced changes in the striatal dopamine transporter and (3)H-dopamine release in these two groups of monkeys. The striatal dopamine transporter was reduced to 54% and 28% of control in mild-moderately and more severely parkinsonian monkeys, respectively. However, basal, K(+), α4β2* and α6β2* nAChR-evoked (3)H-dopamine release were near control levels in striatum of mild-moderately parkinsonian monkeys. By contrast, these same release measures were reduced to a significantly greater extent in striatum of more severely parkinsonian monkeys. Thus, nicotine best improves LIDs in lesioned monkeys in which striatal dopamine transmission is still relatively intact. These data suggest that nicotine treatment would most effectively reduce LIDs in patients with mild to moderate Parkinson's disease. Copyright © 2012 Elsevier Inc. All rights reserved.

Method and apparatus for the management of hazardous waste material

DOEpatents

Murray, Jr., Holt

1995-01-01

A container for storing hazardous waste material, particularly radioactive waste material, consists of a cylindrical body and lid of precipitation hardened C17510 beryllium-copper alloy, and a channel formed between the mated lid and body for receiving weld filler material of C17200 copper-beryllium alloy. The weld filler material has a precipitation hardening temperature lower than the aging kinetic temperature of the material of the body and lid, whereby the weld filler material is post weld heat treated for obtaining a weld having substantially the same physical, thermal, and electrical characteristics as the material of the body and lid. A mechanical seal assembly is located between an interior shoulder of the body and the bottom of the lid for providing a vacuum seal.

Transnasal tendon suspension for the paralyzed lower eyelid.

PubMed

Yoo, John; Matic, Damir

2015-08-01

Paralytic ectropion is a significantly functional and esthetic problem leading to problems with lacrimation, corneal exposure, and poor palpebral closure. Limitations with traditional corrective procedures include poor apposition of the lid to the globe, suboptimal medial canthal position, and high recurrence rates. The objective of this study was to develop a technique of lower-lid suspension using transnasal wiring for the long-term maintenance of lid position. Twenty-three consecutive patients with complete unilateral facial nerve paralysis underwent the procedure, and they were followed up for a median of 27 months (1-73 months). Fifteen of 18 patients maintained their intraoperative lower-lid position beyond the 12-month follow-up. Three patients had a minimal scleral show at 3 months. One of these patients also developed lid laxity seen on the snap test. No perioperative complications were experienced. Transnasal wiring of the lower-lid tendon suspension provides consistent results that are maintained over time. Copyright © 2015 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

Evaluating Benefits of LID Practices at Multiple Spatial Scales Using SUSTAIN

EPA Science Inventory

Low impact development (LID) is a storm water management approach that essentially mimics the way nature works: infiltrate, filter, store, evaporate, and detain runoff close to its source. LID practices are distributed in nature, and they work on decentralized micro-scales and m...

Super-long bridges with floating towers: the role of multi-box decks and Hardware-In-the-Loop technology for wind tunnel tests

NASA Astrophysics Data System (ADS)

Zasso, A.; Argentini, T.; Bayati, I.; Belloli, M.; Rocchi, D.

2017-12-01

The super long fjord crossings in E39 Norwegian project pose new challenges to long span bridge design and construction technology. Proposed solutions should consider the adoption of bridge deck with super long spans or floating solutions for at least one of the towers, due to the relevant fjord depth. At the same time, the exposed fjord environment, possibly facing the open ocean, calls for higher aerodynamic stability performances. In relation to this scenario, the present paper addresses two topics: 1) the aerodynamic advantages of multi-box deck sections in terms of aeroelastic stability, and 2) an experimental setup in a wind tunnel able to simulate the aeroelastic bridge response including the wave forcing on the floating.

Floating Offshore Wind in California: Gross Potential for Jobs and Economic Impacts from Two Future Scenarios

DOE Office of Scientific and Technical Information (OSTI.GOV)

Speer, Bethany; Keyser, David; Tegen, Suzanne

Construction of the first offshore wind farm in the United States began in 2015, using fixed platform structures that are appropriate for shallow seafloors, like those located off of the East Coast and mid-Atlantic. However, floating platforms, which have yet to be deployed commercially, will likely need to anchor to the deeper seafloor if deployed off of the West Coast. To analyze the employment and economic potential for floating offshore wind along the West Coast, the Bureau of Ocean Energy Management (BOEM) has commissioned the National Renewable Energy Laboratory (NREL) to analyze two hypothetical, large-scale deployment scenarios for California: 16more » GW of offshore wind by 2050 (Scenario A) and 10 GW of offshore wind by 2050 (Scenario B). The results of this analysis can be used to better understand the general scales of economic opportunities that could result from offshore wind development. Results show total state gross domestic product (GDP) impacts of $16.2 billion in Scenario B or $39.7 billion in Scenario A for construction; and $3.5 billion in Scenario B or $7.9 billion in Scenario A for the operations phases.« less

Standard Waste Box Lid Screw Removal Option Testing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anast, Kurt Roy

This report provides results from test work conducted to resolve the removal of screws securing the standard waste box (SWB) lids that hold the remediated nitrate salt (RNS) drums. The test work evaluated equipment and process alternatives for removing the 42 screws that hold the SWB lid in place. The screws were secured with a red Loctite thread locker that makes removal very difficult because the rivets that the screw threads into would slip before the screw could be freed from the rivet, making it impossible to remove the screw and therefore the SWB lid.

Method and apparatus for the management of hazardous waste material

DOEpatents

Murray, H. Jr.

1995-02-21

A container for storing hazardous waste material, particularly radioactive waste material, consists of a cylindrical body and lid of precipitation hardened C17510 beryllium-copper alloy, and a channel formed between the mated lid and body for receiving weld filler material of C17200 copper-beryllium alloy. The weld filler material has a precipitation hardening temperature lower than the aging kinetic temperature of the material of the body and lid, whereby the weld filler material is post weld heat treated for obtaining a weld having substantially the same physical, thermal, and electrical characteristics as the material of the body and lid. A mechanical seal assembly is located between an interior shoulder of the body and the bottom of the lid for providing a vacuum seal. 40 figs.

Periorbital hemangiomas.

PubMed

Goldberg, N S; Rosanova, M A

1992-10-01

1. Any hemangioma that involves the upper or lower lid and leads to partial closure in infancy may interfere with or prevent development of normal binocular vision in a matter of days to weeks. 2. Hemangiomas least likely to interfere with vision are lower lid lesions occupying one third of the lid margin or less, not extending beyond the eyelid region, and resolving early. 3. Hemangiomas associated with deprivation amblyopia (with or without anisometropia) are lesions occupying more than one half of the lid margin, extending beyond the eyelid region, resolving late, and obstructing the visual axis. 4. Hemangiomas associated with isolated anisometropic amblyopia are local but bulky lesions that are usually but not always restricted to the upper lid, closing the eye partly and resolving late. 5. The treatment of choice for periorbital hemangiomas is corticosteroids, either systemic or intralesional.

Retrofitting the Low Impact Development Practices into Developed Urban areas Including Barriers and Potential Solution

NASA Astrophysics Data System (ADS)

Shafique, Muhammad; Kim, Reeho

2017-06-01

Low impact development (LID)/green infrastructure (GI) practices have been identified as the sustainable practices of managing the stormwater in urban areas. Due to the increasing population, most of the cities are more developing which results in the change of natural area into impervious areas (roads, buildings etc.). Moreover, urbanization and climate change are causing many water-related problems and making over cities unsafe and insecure. Under these circumstances, there is a need to introduce new stormwater management practices into developed cities to reduce the adverse impacts of urbanization. For this purpose, retrofitting low impact development practices demands more attention to reduce these water-related problems and trying to make our cities sustainable. In developed areas, there is a little space is available for the retrofitting of LID practices for the stormwater management. Therefore, the selection of an appropriate place to retrofitting LID practices needs more concern. This paper describes the successfully applied retrofitting LID practices around the globe. It also includes the process of applying retrofitting LID practices at the suitable place with the suitable combination. Optimal places for the retrofitting of different LID practices are also mentioned. This paper also highlights the barriers and potential solutions of retrofitting LID practices in urban areas.

Application of Mycobacterium Leprae-specific cellular and serological tests for the differential diagnosis of leprosy from confounding dermatoses.

PubMed

Freitas, Aline Araújo; Hungria, Emerith Mayra; Costa, Maurício Barcelos; Sousa, Ana Lúcia Osório Maroccolo; Castilho, Mirian Lane Oliveira; Gonçalves, Heitor Sá; Pontes, Maria Araci Andrade; Duthie, Malcolm S; Stefani, Mariane Martins Araújo

2016-10-01

Mycobacterium leprae-specific serological and cell-mediated-immunity/CMI test were evaluated for the differential diagnosis of multibacillary/MB, and paucibacillary/PB leprosy from other dermatoses. Whole-blood assay/WBA/IFNγ stimulated with LID-1 antigen and ELISA tests for IgG to LID-1 and IgM to PGL-I were performed. WBA/LID-1/IFNγ production was observed in 72% PB, 11% MB leprosy, 38% dermatoses, 40% healthy endemic controls/EC. The receiver operating curve/ROC for WBA/LID-1 in PB versus other dermatoses showed 72.5% sensitivity, 61.5% specificity and an area-under-the-curve/AUC=0.75; 74% positive predictive value/PPV, 59% negative predictive value/NPV. Anti PGL-I serology was positive in 67% MB, 8% PB leprosy, 6% of other dermatoses; its sensitivity for MB=66%, specificity=93%, AUC=0.89; PPV=91%, NPV=72%. Anti-LID-1 serology was positive in 87% MB, 7% PB leprosy, all other participants were seronegative; 87.5% sensitivity for MB, 100% specificity, AUC=0.97; PPV=100%, NPV=88%. In highly endemic areas anti-LID-1/PGL-I serology and WBA/LID-1-represent useful tools for the differential diagnosis of leprosy from other confounding dermatoses. Copyright © 2016 Elsevier Inc. All rights reserved.

Post Surgical Giant Epidermal Inclusion Cyst of the Lid and Orbit- A Rare Case

PubMed Central

Mandal, Aparna; Bandyopadhya, Arghya

2015-01-01

Epidermoid cyst within the lid and orbit is extremely rare. Epidermoid tumours are inclusion of ectodermal elements in the site not normally containing these structures. It is of two types; primary type related to implantation of ectoderm at the time of closure of the neural groove and secondary type caused by post traumatic inclusion of the surface epithelium. A 45-year-old male had complaint of swelling on the right upper lid and orbital region. It first appeared two years back. It was painless progressively increased in size and shape. There was difficulty in opening of eye lid due to large swelling, feeling of heaviness in the right upper lid and occasional headache. There was history of right eye ocular infection following vegetative matter injury three years back. Evisceration of right eye was done for aforementioned reason. USG report shows cystic encapsulated mass with calcification foci in right upper lid-orbital region with fat component. MRI right orbit shows fairly large hyperintense cystic lesion seen involving right orbit with posterior extension up to optic canal. No intracranial extension. FNAC confirmed epidermal inclusion cyst. We did upper lid reconstruction with removal of mass. We have successfully removed the mass without any complication and with one year follow-up there is no recurrence. PMID:26500932

Morphological and electrophysiological changes in intratelencephalic-type pyramidal neurons in the motor cortex of a rat model of levodopa-induced dyskinesia.

PubMed

Ueno, Tatsuya; Yamada, Junko; Nishijima, Haruo; Arai, Akira; Migita, Keisuke; Baba, Masayuki; Ueno, Shinya; Tomiyama, Masahiko

2014-04-01

Levodopa-induced dyskinesia (LID) is a major complication of long-term dopamine replacement therapy for Parkinson's disease, and becomes increasingly problematic in the advanced stage of the disease. Although the cause of LID still remains unclear, there is accumulating evidence from animal experiments that it results from maladaptive plasticity, resulting in supersensitive excitatory transmission at corticostriatal synapses. Recent work using transcranial magnetic stimulation suggests that the motor cortex displays the same supersensitivity in Parkinson's disease patients with LID. To date, the cellular mechanisms underlying the abnormal cortical plasticity have not been examined. The morphology of the dendritic spines has a strong relationship to synaptic plasticity. Therefore, we explored the spine morphology of pyramidal neurons in the motor cortex in a rat model of LID. We used control rats, 6-hydroxydopamine-lesioned rats (a model of Parkinson's disease), 6-hydroxydopamine-lesioned rats chronically treated with levodopa (a model of LID), and control rats chronically treated with levodopa. Because the direct pathway of the basal ganglia plays a central role in the development of LID, we quantified the density and size of dendritic spines in intratelencephalic (IT)-type pyramidal neurons in M1 cortex that project to the striatal medium spiny neurons in the direct pathway. The spine density was not different among the four groups. In contrast, spine size became enlarged in the Parkinson's disease and LID rat models. The enlargement was significantly greater in the LID model than in the Parkinson's disease model. This enlargement of the spines suggests that IT-type pyramidal neurons acquire supersensitivity to excitatory stimuli. To confirm this possibility, we monitored miniature excitatory postsynaptic currents (mEPSCs) in the IT-type pyramidal neurons in M1 cortex using whole-cell patch clamp. The amplitude of the mEPSCs was significantly increased in the LID model compared with the control. This indicates that the IT-type pyramidal neurons become hyperexcited in the LID model, paralleling the enlargement of spines. Thus, spine enlargement and the resultant hyperexcitability of IT-type pyramidal neurons in M1 cortex might contribute to the abnormal cortical neuronal plasticity in LID. Copyright © 2013 Elsevier Inc. All rights reserved.

Some Ideas on Racing Seaplanes

NASA Technical Reports Server (NTRS)

Pegna, Giovanni

1932-01-01

This report presents the author's designs and construction of various seaplanes to raced in the Schneider Cup. The results of tests are presented as well as discussions of various structures like floats and wings.

Erratum: "Low vibration laboratory with a single-stage vibration isolation for microscopy applications" [Rev. Sci. Instrum. 88, 023703 (2017)

NASA Astrophysics Data System (ADS)

Voigtländer, Bert; Coenen, Peter; Cherepanov, Vasily; Borgens, Peter; Duden, Thomas; Tautz, F. Stefan

2018-01-01

The construction and the vibrational performance of a low vibration laboratory for microscopy applications comprising a 100 ton floating foundation supported by passive pneumatic isolators (air springs), which rest themselves on a 200 ton solid base plate is discussed. The optimization of the air spring system lead to a vibration level on the floating floor below that induced by an acceleration of 10 ng for most frequencies. Additional acoustic and electromagnetic isolation is accomplished by a room-in-room concept.

Mass Fluxes of Ice and Oxygen Across the Entire Lid of Lake Vostok from Observations of Englacial Radiowave Attenuation

NASA Astrophysics Data System (ADS)

Winebrenner, D. P.; Kintner, P. M. S.; MacGregor, J. A.

2017-12-01

Over deep Antarctic subglacial lakes, spatially varying ice thickness and the pressure-dependent melting point of ice result in areas of melting and accretion at the ice-water interface, i.e., the lake lid. These ice mass fluxes drive lake circulation and, because basal Antarctic ice contains air-clathrate, affect the input of oxygen to the lake, with implications for subglacial life. Inferences of melting and accretion from radar-layer tracking and geodesy are limited in spatial coverage and resolution. Here we develop a new method to estimate rates of accretion, melting, and the resulting oxygen input at a lake lid, using airborne radar data over Lake Vostok together with ice-temperature and chemistry data from the Vostok ice core. Because the lake lid is a coherent reflector of known reflectivity (at our radar frequency), we can infer depth-averaged radiowave attenuation in the ice, with spatial resolution 1 km along flight lines. Spatial variation in attenuation depends mostly on variation in ice temperature near the lid, which in turn varies strongly with ice mass flux at the lid. We model ice temperature versus depth with ice mass flux as a parameter, thus linking that flux to (observed) depth-averaged attenuation. The resulting map of melt- and accretion-rates independently reproduces features known from earlier studies, but now covers the entire lid. We find that accretion is dominant when integrated over the lid, with an ice imbalance of 0.05 to 0.07 km3 a-1, which is robust against uncertainties.

The Kinase Fyn As a Novel Intermediate in L-DOPA-Induced Dyskinesia in Parkinson's Disease.

PubMed

Sanz-Blasco, Sara; Bordone, Melina P; Damianich, Ana; Gomez, Gimena; Bernardi, M Alejandra; Isaja, Luciana; Taravini, Irene R; Hanger, Diane P; Avale, M Elena; Gershanik, Oscar S; Ferrario, Juan E

2018-06-01

Dopamine replacement therapy with L-DOPA is the treatment of choice for Parkinson's disease; however, its long-term use is frequently associated with L-DOPA-induced dyskinesia (LID). Many molecules have been implicated in the development of LID, and several of these have been proposed as potential therapeutic targets. However, to date, none of these molecules have demonstrated full clinical efficacy, either because they lie downstream of dopaminergic signaling, or due to adverse side effects. Therefore, discovering new strategies to reduce LID in Parkinson's disease remains a major challenge. Here, we have explored the tyrosine kinase Fyn, as a novel intermediate molecule in the development of LID. Fyn, a member of the Src kinase family, is located in the postsynaptic density, where it regulates phosphorylation of the NR2B subunit of the N-methyl-D-aspartate (NMDA) receptor in response to dopamine D1 receptor stimulation. We have used Fyn knockout and wild-type mice, lesioned with 6-hydroxydopamine and chronically treated with L-DOPA, to investigate the role of Fyn in the induction of LID. We found that mice lacking Fyn displayed reduced LID, ΔFosB accumulation and NR2B phosphorylation compared to wild-type control mice. Pre-administration of saracatinib (AZD0530), an inhibitor of Fyn activity, also significantly reduced LID in dyskinetic wild-type mice. These results support that Fyn has a critical role in the molecular pathways affected during the development of LID and identify Fyn as a novel potential therapeutic target for the management of dyskinesia in Parkinson's disease.

Importance of the lid and cap domains for the catalytic activity of gastric lipases.

PubMed

Miled, N; Bussetta, C; De caro, A; Rivière, M; Berti, L; Canaan, S

2003-09-01

Human gastric lipase (HGL) is an enzyme secreted by the stomach, which is stable and active despite the highly acidic environment. It has been clearly established that this enzyme is responsible for 30% of the fat digestion processes occurring in human. This globular protein belongs to the alpha/beta hydrolase fold family and its catalytic serine is deeply buried under a domain called the extrusion domain, which is composed of a 'cap' domain and a segment consisting of 58 residues, which can be defined as a lid. The exact roles played by the cap and the lid domains during the catalytic step have not yet been elucidated. We have recently solved the crystal structure of the open form of the dog gastric lipase in complex with a covalent inhibitor. The detergent molecule and the inhibitor were mimicking a triglyceride substrate that would interact with residues belonging to both the cap and the lid domains. In this study, we have investigated the role of the cap and the lid domains, using site-directed mutagenesis procedures. We have produced truncated mutants lacking the lid and the cap. After expressing these mutants and purifying them, their activity was found to have decreased drastically in comparison with the wild type HGL. The lid and the cap domains play an important role in the catalytic reaction mechanism. Based on these results and the structural data (open form of DGL), we have pointed out the cap and the lid residues involved in the binding with the lipidic substrate.

75 FR 38878 - Transportation for Individuals With Disabilities: Passenger Vessels

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-06

..., excursion vessels, sightseeing vessels, floating restaurants, cruise ships, and others. Cruise ships are a... the PVO owns or leases the terminal or exercises control over its selection, design, construction, or...

46 CFR 160.057-3 - Materials, workmanship, construction, and performance requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... when presented with supporting data. Igniter systems shall be of corrosion-resistant metal. The... subjected to frigid or tropical climates, or both. (b) Workmanship. Floating orange smoke distress signals...

46 CFR 160.057-3 - Materials, workmanship, construction, and performance requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... when presented with supporting data. Igniter systems shall be of corrosion-resistant metal. The... subjected to frigid or tropical climates, or both. (b) Workmanship. Floating orange smoke distress signals...

46 CFR 160.057-3 - Materials, workmanship, construction, and performance requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... when presented with supporting data. Igniter systems shall be of corrosion-resistant metal. The... subjected to frigid or tropical climates, or both. (b) Workmanship. Floating orange smoke distress signals...

46 CFR 160.057-3 - Materials, workmanship, construction, and performance requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... when presented with supporting data. Igniter systems shall be of corrosion-resistant metal. The... subjected to frigid or tropical climates, or both. (b) Workmanship. Floating orange smoke distress signals...

A Leadership Identity Development Model: Applications from a Grounded Theory

ERIC Educational Resources Information Center

Komives, Susan R.; Mainella, Felicia C.; Longerbeam, Susan D.; Osteen, Laura; Owen, Julie E.

2006-01-01

This article describes a stage-based model of leadership identity development (LID) that resulted from a grounded theory study on developing a leadership identity (Komives, Owen, Longerbeam, Mainella, & Osteen, 2005). The LID model expands on the leadership identity stages, integrates the categories of the grounded theory into the LID model, and…

Green infrastructure and its catchment-scale effects: an emerging science

PubMed Central

Golden, Heather E.; Hoghooghi, Nahal

2018-01-01

Urbanizing environments alter the hydrological cycle by redirecting stream networks for stormwater and wastewater transmission and increasing impermeable surfaces. These changes thereby accelerate the runoff of water and its constituents following precipitation events, alter evapotranspiration processes, and indirectly modify surface precipitation patterns. Green infrastructure, or low-impact development (LID), can be used as a standalone practice or in concert with gray infrastructure (traditional stormwater management approaches) for cost-efficient, decentralized stormwater management. The growth in LID over the past several decades has resulted in a concomitant increase in research evaluating LID efficiency and effectiveness, but mostly at localized scales. There is a clear research need to quantify how LID practices affect water quantity (i.e., runoff and discharge) and quality at the scale of catchments. In this overview, we present the state of the science of LID research at the local scale, considerations for scaling this research to catchments, recent advances and findings in scaling the effects of LID practices on water quality and quantity at catchment scales, and the use of models as novel tools for these scaling efforts. PMID:29682288

Cu gettering by phosphorus-doped emitters in p-type silicon: Effect on light-induced degradation

NASA Astrophysics Data System (ADS)

Inglese, Alessandro; Laine, Hannu S.; Vähänissi, Ville; Savin, Hele

2018-01-01

The presence of copper (Cu) contamination is known to cause relevant light-induced degradation (Cu-LID) effects in p-type silicon. Due to its high diffusivity, Cu is generally regarded as a relatively benign impurity, which can be readily relocated during device fabrication from the wafer bulk, i.e. the region affected by Cu-LID, to the surface phosphorus-doped emitter. This contribution examines in detail the impact of gettering by industrially relevant phosphorus layers on the strength of Cu-LID effects. We find that phosphorus gettering does not always prevent the occurrence of Cu-LID. Specifically, air-cooling after an isothermal anneal at 800°C results in only weak impurity segregation to the phosphorus-doped layer, which turns out to be insufficient for effectively mitigating Cu-LID effects. Furthermore, we show that the gettering efficiency can be enhanced through the addition of a slow cooling ramp (-4°C/min) between 800°C and 600°C, resulting in the nearly complete disappearance of Cu-LID effects.

Green infrastructure and its catchment-scale effects: an emerging science.

PubMed

Golden, Heather E; Hoghooghi, Nahal

2018-01-01

Urbanizing environments alter the hydrological cycle by redirecting stream networks for stormwater and wastewater transmission and increasing impermeable surfaces. These changes thereby accelerate the runoff of water and its constituents following precipitation events, alter evapotranspiration processes, and indirectly modify surface precipitation patterns. Green infrastructure, or low-impact development (LID), can be used as a standalone practice or in concert with gray infrastructure (traditional stormwater management approaches) for cost-efficient, decentralized stormwater management. The growth in LID over the past several decades has resulted in a concomitant increase in research evaluating LID efficiency and effectiveness, but mostly at localized scales. There is a clear research need to quantify how LID practices affect water quantity (i.e., runoff and discharge) and quality at the scale of catchments. In this overview, we present the state of the science of LID research at the local scale, considerations for scaling this research to catchments, recent advances and findings in scaling the effects of LID practices on water quality and quantity at catchment scales, and the use of models as novel tools for these scaling efforts.

Nucleotide-dependent switch in proteasome assembly mediated by the Nas6 chaperone

PubMed Central

Li, Frances; Tian, Geng; Langager, Deanna; Sokolova, Vladyslava; Finley, Daniel; Park, Soyeon

2017-01-01

The proteasome is assembled via the nine-subunit lid, nine-subunit base, and 28-subunit core particle (CP). Previous work has shown that the chaperones Rpn14, Nas6, Hsm3, and Nas2 each bind a specific ATPase subunit of the base and antagonize base–CP interaction. Here, we show that the Nas6 chaperone also obstructs base–lid association. Nas6 alternates between these two inhibitory modes according to the nucleotide state of the base. When ATP cannot be hydrolyzed, Nas6 interferes with base–lid, but not base–CP, association. In contrast, under conditions of ATP hydrolysis, Nas6 obstructs base–CP, but not base–lid, association. Modeling of Nas6 into cryoelectron microscopy structures of the proteasome suggests that Nas6 controls both base–lid affinity and base–CP affinity through steric hindrance; Nas6 clashes with the lid in the ATP-hydrolysis–blocked proteasome, but clashes instead with the CP in the ATP-hydrolysis–competent proteasome. Thus, Nas6 provides a dual mechanism to control assembly at both major interfaces of the proteasome. PMID:28137839

Upper lid crease approach for margin rotation in trachomatous cicatricial entropion without external sutures.

PubMed

Cruz, Antonio Augusto Velasco E; Akaishi, Patricia M S; Al-Dufaileej, Mohammed; Galindo-Ferreiro, Alicia

2015-01-01

To describe the use of a lid crease incision for upper eyelid margin rotation in cicatricial entropion combining internal traction on the anterior lamella, tarsotomy, and tarsal overlap without external sutures. Surgical description: The main steps of the procedure consisted of exposure of the entire tarsal plate up to the eyelashes followed by tarsotomy through the conjunctiva. A double-armed 6.0 polyglactin suture was then passed through the distal tarsal fragment to the marginal section of the orbicularis oculi muscle. As the sutures were tied, the distal tarsus advanced over the marginal section, and traction was exerted on the marginal strip of the orbicularis muscle. There were no bolsters or external knots. The pretarsal skin-muscle flap was closed with a 6.0 plain gut suture. We used this procedure at a tertiary hospital in Saudi Arabia from 2013 to 2014. Sixty upper lids of 40 patients (23 women and 17 men) were operated on, with an age range of 44-99 years [mean ± standard deviation (SD) = 70.9 ± 13.01 years]. Bilateral surgery was performed on 21 patients. Follow-up ranged from 1 to 12 months (mean 3.0 ± 2.71 months). Forty percent of the patients (24 lids) had more than 3 months' follow-up. The postoperative lid margin position was good in all cases. Trichiasis (two lashes) was observed in only one patient with unilateral entropion on the medial aspect of the operated lid. The upper lid margin can be effectively rotated through a lid crease incision with internal sutures. The technique combines the main mechanisms of the Wies and Trabut approaches and avoids the use of bolsters or external sutures, which require a second consultation to be removed. Some other lid problems, such as ptosis, retraction, or dermatochalasis, can be concomitantly addressed during the procedure.

Structure of human pancreatic lipase-related protein 2 with the lid in an open conformation.

PubMed

Eydoux, Cécilia; Spinelli, Silvia; Davis, Tara L; Walker, John R; Seitova, Alma; Dhe-Paganon, Sirano; De Caro, Alain; Cambillau, Christian; Carrière, Frédéric

2008-09-09

Access to the active site of pancreatic lipase (PL) is controlled by a surface loop, the lid, which normally undergoes conformational changes only upon addition of lipids or amphiphiles. Structures of PL with their lids in the open and functional conformation have required cocrystallization with amphiphiles. Here we report two crystal structures of wild-type and unglycosylated human pancreatic lipase-related protein 2 (HPLRP2) with the lid in an open conformation in the absence of amphiphiles. These structures solved independently are strikingly similar, with some residues of the lid being poorly defined in the electron-density map. The open conformation of the lid is however different from that previously observed in classical liganded PL, suggesting different kinetic properties for HPLRP2. Here we show that the HPLRP2 is directly inhibited by E600, does not present interfacial activation, and acts preferentially on substrates forming monomers or small aggregates (micelles) dispersed in solution like monoglycerides, phospholipids and galactolipids, whereas classical PL displays reverse properties and a high specificity for unsoluble substrates like triglycerides and diglycerides forming oil-in-water interfaces. These biochemical properties imply that the lid of HPLRP2 is likely to spontaneously adopt in solution the open conformation observed in the crystal structure. This open conformation generates a large cavity capable of accommodating the digalactose polar head of galactolipids, similar to that previously observed in the active site of the guinea pig PLRP2, but absent from the classical PL. Most of the structural and kinetic properties of HPLRP2 were found to be different from those of rat PLRP2, the structure of which was previously obtained with the lid in a closed conformation. Our findings illustrate the essential role of the lid in determining the substrate specificity and the mechanism of action of lipases.

[Descriptive study on basal cell eyelid carcinoma].

PubMed

Pfeiffer, M J; Pfeiffer, N; Valor, C

2015-09-01

To describe a series of cases of basal cell carcinomas of the eyelid. A descriptive and retrospective study was conducted by reviewing the medical outcome, histopathological history, and photographic images of 200 patients with basal cell eyelid carcinomas. All were treated in the Herzog Carl Theodor Eye Hospital in Munich, Germany, between 2000 and 2013. In the present study, it was found that females are more affected than males. The mean age of presentation of the tumor occurred at the age of 70 years. In 50% of the cases the tumor was found on the lower lid, especially medially from the center of the lid. The lid margin was involved in 47% of all tumors. The mean diameter was 9.2mm. The recurrence rate after surgery with histologically clear resection margins was 5%. There was a significant relationship between tumor diameter and age. As tumors where located farther away from medial and closer to the lid margin, they became larger. There is a predominance of women affected by this tumor. This may be related to the fact that the sample was taken from those attending an oculoplastic surgery clinic, where there are generally more women than men attending. The formation of basal cell carcinomas increases with age. The infrequent involvement of the upper lid could be explained by the protection of the the eyebrow. The frequent involvement of the lower lid may be due to the light reflection (total reflection) by the cornea on the lower lid margin. Also chemical and physical effects of the tears may be more harmful on the lower lid. Patients tend to ask for medical help when they are females, younger, when the tumor is closer to the medial canthus or when the tumor is away from the lid margin. Copyright © 2014 Sociedad Española de Oftalmología. Published by Elsevier España, S.L.U. All rights reserved.

The effects of cysteamine in a mouse model of levodopa-induced dyskinesias.

PubMed

David, Linda S; Saint-Pierre, Martine; Lamontagne-Proulx, Jérôme; Cicchetti, Francesca

2018-01-01

Levo-dopa (L-DOPA) has shown significant and long-lasting efficacy in the treatment of motor features characteristic of Parkinson's disease (PD). However, the effects tend to wear off at a time typically when side-effects, such as L-DOPA induced dyskinesias (LIDs), start to emerge and for which the treatment options are very limited. In recent years, we have reported on the neuroprotective and neurorestorative properties of the compounds cystamine/cysteamine in ameliorating several aspects of PD. Building on these observations, we set out to further evaluate the benefits of cysteamine on LIDs. We thus treated mice displaying LIDs with single cysteamine challenges at various doses (20, 50 and 30mg/kg) or chronically for 2 weeks using cysteamine at a dose of 30mg/kg. None of the regimens nor doses ameliorated any LID-related behavioral impairments. Mice displaying LIDs did, however, respond to a single treatment of 60mg/kg of amantadine, a drug used to clinically manage LIDs. Taken together, our results suggest that cysteamine does not induce benefits on LIDs, at least at the doses and regimen tested in our study. However, the disease-modifying effects depicted by cystamine/cysteamine, which we have shown in several reports, would strongly encourage its continued evaluation in the clinical setting. Copyright © 2017 Elsevier B.V. All rights reserved.

Effect of topical rebamipide on goblet cells in the lid wiper of human conjunctiva

PubMed Central

Kase, Satoru; Shinohara, Toshiya; Kase, Manabu; Ishida, Susumu

2017-01-01

It has been demonstrated that topical administration of rebamipide, which is an antiulcer agent, increases the mucin level of the tear film and ameliorates ocular surface conditions such as lid wiper epitheliopathy. The aim of the present study was to analyze the changes in goblet cell number, cell proliferation, and epidermal growth factor receptor (EGFR) induced by topical rebamipide addition to the lid wiper of humans. A total of 30 eyelid tissue samples were obtained during involutional entropion surgeries, fixed in paraformaldehyde, embedded in paraffin and divided into two groups: Rebamipide or non-rebamipide. The tissues in the rebamipide group were obtained from patients who had a medical history of topical rebamipide use prior to surgery. The number of goblet cells was counted under light microscopy. A total of 22 eyelid tissue samples were further examined using immunohistochemistry with anti-Ki-67 and anti-EGFR antibodies to evaluate cell proliferation and EGFR expression, respectively. Histologically, the lid wiper and palpebral conjunctiva were clearly identified in the tissues. The number of goblet cells was significantly higher in the rebamipide group compared with the non-rebamipide group (P=0.0367). There was no significant difference in lid wiper cell proliferation between the rebamipide and non-rebamipide groups. Immunohistochemistry revealed that EGFR levels in the lid wiper epithelial cells were significantly higher in the rebamipide group compared with the non-rebamipide group (P=0.0237). These results suggest that topical rebamipide application increases the number of goblet cells in the lid wiper, which in turn upregulates the expression of EGFR. These findings may be clinically relevant and provide a therapeutic basis for the treatment of ocular disease such as dry eye and lid wiper epitheliopathy. PMID:28587435

Effect of topical rebamipide on goblet cells in the lid wiper of human conjunctiva.

PubMed

Kase, Satoru; Shinohara, Toshiya; Kase, Manabu; Ishida, Susumu

2017-06-01

It has been demonstrated that topical administration of rebamipide, which is an antiulcer agent, increases the mucin level of the tear film and ameliorates ocular surface conditions such as lid wiper epitheliopathy. The aim of the present study was to analyze the changes in goblet cell number, cell proliferation, and epidermal growth factor receptor (EGFR) induced by topical rebamipide addition to the lid wiper of humans. A total of 30 eyelid tissue samples were obtained during involutional entropion surgeries, fixed in paraformaldehyde, embedded in paraffin and divided into two groups: Rebamipide or non-rebamipide. The tissues in the rebamipide group were obtained from patients who had a medical history of topical rebamipide use prior to surgery. The number of goblet cells was counted under light microscopy. A total of 22 eyelid tissue samples were further examined using immunohistochemistry with anti-Ki-67 and anti-EGFR antibodies to evaluate cell proliferation and EGFR expression, respectively. Histologically, the lid wiper and palpebral conjunctiva were clearly identified in the tissues. The number of goblet cells was significantly higher in the rebamipide group compared with the non-rebamipide group (P=0.0367). There was no significant difference in lid wiper cell proliferation between the rebamipide and non-rebamipide groups. Immunohistochemistry revealed that EGFR levels in the lid wiper epithelial cells were significantly higher in the rebamipide group compared with the non-rebamipide group (P=0.0237). These results suggest that topical rebamipide application increases the number of goblet cells in the lid wiper, which in turn upregulates the expression of EGFR. These findings may be clinically relevant and provide a therapeutic basis for the treatment of ocular disease such as dry eye and lid wiper epitheliopathy.

Coherence of neuronal firing of the entopeduncular nucleus with motor cortex oscillatory activity in the 6-OHDA rat model of Parkinson's disease with levodopa-induced dyskinesias.

PubMed

Jin, Xingxing; Schwabe, Kerstin; Krauss, Joachim K; Alam, Mesbah

2016-04-01

The pathophysiological mechanisms leading to dyskinesias in Parkinson's disease (PD) after long-term treatment with levodopa remain unclear. This study investigates the neuronal firing characteristics of the entopeduncular nucleus (EPN), the rat equivalent of the human globus pallidus internus and output nucleus of the basal ganglia, and its coherence with the motor cortex (MCx) field potentials in the unilateral 6-OHDA rat model of PD with and without levodopa-induced dyskinesias (LID). 6-hydroxydopamine-lesioned hemiparkinsonian (HP) rats, 6-OHDA-lesioned HP rats with LID (HP-LID) rats, and naïve controls were used for recording of single-unit activity under urethane (1.4 g/kg, i.p) anesthesia in the EPN "on" and "off" levodopa. Over the MCx, the electrocorticogram output was recorded. Analysis of single-unit activity in the EPN showed enhanced firing rates, burst activity, and irregularity compared to naïve controls, which did not differ between drug-naïve HP and HP-LID rats. Analysis of EPN spike coherence and phase-locked ratio with MCx field potentials showed a shift of low (12-19 Hz) and high (19-30 Hz) beta oscillatory activity between HP and HP-LID groups. EPN theta phase-locked ratio was only enhanced in HP-LID compared to HP rats. Overall, levodopa injection had no stronger effect in HP-LID rats than in HP rats. Altered coherence and changes in the phase lock ratio of spike and local field potentials in the beta range may play a role for the development of LID.

Investigation of Preferential Flow in Low Impact Development Practice

NASA Astrophysics Data System (ADS)

Liu, L.; Cao, R.; Wang, C.; Jiang, W.; Wang, J.; Xia, Z.

2016-12-01

The characteristics of preferential flow in soil affect Low Impact Development (LID) practices in two aspects. On the one hand, preferential flow may facilitate drainage of stormwater by causing non-uniform movement of water through a small portion of media (such as cracks and holes), and thus leading to much faster transport of water and solutes in one specific direction than others. On the other hand, within a certain ranges, preferential flow may weaken the subgrade capacity of pressure and/or shear stress resistance. Therefore, for the purpose of improving LID practices, there may exist an optimum scenario with a high allowable flowrate and least negative impact of resistance capacity for a soil layer. This project aims to assist the LID design by exploring the features of preferential flow in different soil compositions, studying how different flow paths affect the stability of subgrade, preliminarily analyzing the sensitivity of preferential flow impacting on drainage capacity and subgrade stability in the LID, and further optimizing LID practices. Accordingly, the concepts of Essential Direction Path, Unessential Direction Path and the Sensitivity Coefficient are defined and analyzed to simulate a hypothetical funneling scenario in LID practice. Both irrigation apparatus experiments and numerical models are utilized in this research to investigate the features of preferential flow, effective strength and overall shear strength. The main conclusions include: (1) Investigation of preferential flow characteristics in essential direction path and unessential direction path, respectively; (2) Optimum design of preferential flow in LID practice; (3) Transport capacity determination of preferential flow path in different soils; (4) Study of preferential flow impact on roadbed stability. KEY WORDS: Preferential Flow, Subgrade stability, LID, Sensitivity Coefficient, Funneling Preferential Flow Path

Igf-I regulates pheochromocytoma cell proliferation and survival in vitro and in vivo.

PubMed

Fernández, María Celia; Venara, Marcela; Nowicki, Susana; Chemes, Héctor E; Barontini, Marta; Pennisi, Patricia A

2012-08-01

IGFs are involved in malignant transformation and growth of several tissues, including the adrenal medulla. The present study was designed to evaluate the impact of IGF-I on pheochromocytoma development. We used a murine pheochromocytoma (MPC) cell line (MPC4/30) and an animal model with a reduction of 75% in circulating IGF-I levels [liver-IGF-I-deficient (LID) mice] to perform studies in vitro and in vivo. We found that, in culture, IGF-I stimulation increases proliferation, migration, and anchorage-independent growth, whereas it inhibits apoptosis of MPC cells. When injected to control and to LID mice, MPC cells grow and form tumors with features of pheochromocytoma. Six weeks after cell inoculation, all control mice developed sc tumors. In contrast, in 73% of LID mice, tumor development was delayed to 7-12 wk, and the remaining 27% did not develop tumors up to 12 wk after inoculation. LID mice harboring MPC cells and treated with recombinant human IGF-I (LID+) developed tumors as controls. Tumors developed in control, LID, and LID+ mice had similar histology and were similarly positive for IGF-I receptor expression. The apoptotic index was higher in tumors from LID mice compared with those from control mice, whereas vascular density was decreased. In summary, our work demonstrates that IGF-I has a critical role in maintaining tumor phenotype and survival of already transformed pheochromocytoma cells and is required for the initial establishment of these tumors, providing encouragement to carry on research studies to address the IGF-I/IGF-I receptor system as a target of therapeutic strategies for pheochromocytoma treatment in the future.

The pumping lid: investigating multi-material 3D printing for equipment-free, programmable generation of positive and negative pressures for microfluidic applications.

PubMed

Begolo, Stefano; Zhukov, Dmitriy V; Selck, David A; Li, Liang; Ismagilov, Rustem F

2014-12-21

Equipment-free pumping is a challenging problem and an active area of research in microfluidics, with applications for both laboratory and limited-resource settings. This paper describes the pumping lid method, a strategy to achieve equipment-free pumping by controlled generation of pressure. Pressure was generated using portable, lightweight, and disposable parts that can be integrated with existing microfluidic devices to simplify workflow and eliminate the need for pumping equipment. The development of this method was enabled by multi-material 3D printing, which allows fast prototyping, including composite parts that combine materials with different mechanical properties (e.g. both rigid and elastic materials in the same part). The first type of pumping lid we describe was used to produce predictable positive or negative pressures via controlled compression or expansion of gases. A model was developed to describe the pressures and flow rates generated with this approach and it was validated experimentally. Pressures were pre-programmed by the geometry of the parts and could be tuned further even while the experiment was in progress. Using multiple lids or a composite lid with different inlets enabled several solutions to be pumped independently in a single device. The second type of pumping lid, which relied on vapor-liquid equilibrium to generate pressure, was designed, modeled, and experimentally characterized. The pumping lid method was validated by controlling flow in different types of microfluidic applications, including the production of droplets, control of laminar flow profiles, and loading of SlipChip devices. We believe that applying the pumping lid methodology to existing microfluidic devices will enhance their use as portable diagnostic tools in limited resource settings as well as accelerate adoption of microfluidics in laboratories.

Characterization of Upper Eyelid Tarsus and Lid Wiper Dimensions.

PubMed

Navascues-Cornago, Maria; Maldonado-Codina, Carole; Gupta, Ruchi; Morgan, Philip B

2016-09-01

To measure various dimensions of the upper tarsal plate and the area of upper lid wiper staining. The repeatability of the method of measurement was investigated. Thirty-five healthy non-contact lens wearers were enrolled. The following parameters were measured from digital images of the upper eyelid captured with a slitlamp camera: length, height, and total area of the tarsal plate and area of lid wiper staining (lissamine green). Measurements were performed in a randomized and masked fashion on two separate occasions by the same investigator using ImageJ (National Institutes of Health). Coefficients of repeatability (COR) were calculated. The dimensions (mean±SD) of the tarsal plate were 20.6±1.9 mm length, 7.9±0.8 mm height, and 103.3±18.8 mm total area. The area of lid wiper staining was 2.7±2.0 mm. No association was found between tarsal dimensions and lid wiper staining (all P>0.05). Image analysis COR values were 0.6 mm tarsal length, 0.1 mm tarsal height, 1.2 mm tarsal area, and 0.4 mm lid wiper staining. There was no significant difference between repeated measurements for any parameter (all P>0.05). Limits of agreement were narrow for all parameters, indicating good agreement between repeated measurements. This work has demonstrated that there is a wide range in the dimensions of the upper tarsal plate in an urban UK population. No association was found between the upper tarsal dimensions and lid wiper staining. ImageJ was shown to be a repeatable method to measure the dimensions of the upper tarsal plate and upper lid wiper staining.

Effect of LID (Registered) processing on the microstructure and mechanical properties of Ti-6Al-4V and Ti-6Al-2Sn-4Zr-2Mo titanium foil-gauge materials

NASA Technical Reports Server (NTRS)

Balckburn, Linda B.

1987-01-01

A study was undertaken to determine the mechanical properties and microstructures resulting from Liquid Interface Diffusion (LID -Registered) processing of foil-gauge specimens of Ti-6Al-4V and Ti-6Al-2Sn-4Zr-2Mo coated with varying amounts of LID material. In addition, the effects of various elevated temperature exposures on the concentration profiles of the LID alloying elements were investigated, using specimens with a narrow strip of LID material applied to the surface. Room and elevated temperature tensile properties were determined for both coated and uncoated specimens. Optical microscopy was used to examine alloy microstructures, and scanning electron microscopy to examine fracture surface morphologies. The chemical concentration profiles of the strip-coated specimens were determined with an electron microprobe.

IBD Selection for the 288kg Prototype SoLid Module

NASA Astrophysics Data System (ADS)

Saunders, D.; SoLid Collaboration

2017-09-01

The SoLid experiment aims to make a measurement of very short baseline neutrino oscillations using reactor antineutrinos. Key to its sensitivity are the experiment’s high spatial and energy resolution, combined with a very suitable reactor source and excellent background rejection. Placed on the surface at just 5 m from the reactor core, the cosmic flux and reactor output lead to a challenging environment. The fine segmentation of the detector, 5 cm cubes, allows the topology of events to be studied to previously unseen precision. This offers new and unexplored handles for tackling these backgrounds - a key requirement for SoLid physics aims. Using the most recent SoLid prototype (288 kg, 20% scale), we present the first selection to focus on IBD signals. This includes descriptions of SoLid signals and backgrounds, and demonstration that the segmentation can lead to gains in orders of magnitude in background rejection.

Evaluation of the capability of low-impact development practices for the removal of heavy metal from urban stormwater runoff.

PubMed

Maniquiz-Redillas, Marla C; Kim, Lee-Hyung

2016-09-01

Low-impact development (LID) and green infrastructure (GI) have recently become well-known methods to capture, collect, retain, and remove pollutants in stormwater runoff. The research was conducted to assess the efficiency of LID/GI systems applied in removing the particulate and dissolved heavy metals (Zn, Pb, Cu, Ni, Cr, Cd, and Fe) from urban stormwater runoff. A total of 82 storm events were monitored over a four-year period (2010-2014) on six LID/GI systems including infiltration trenches, tree box filter, rain garden, and hybrid constructed wetlands employed for the management of road, parking lot, and roof runoff. It was observed that the heavy metal concentration increased proportionally with the total suspended solids concentration. Among the heavy metal constituents, Fe appeared to be highly particulate-bound and was the easiest to remove followed by Zn and Pb; while metals such as Cr, Ni, Cu, and Cd were mostly dissolved and more difficult to remove. The mass fraction ratios of metal constituents at the effluent were increased relative to the influent. All the systems performed well in the removal of particulate-bound metals and were more efficient for larger storms greater than 15 mm wherein more particulate-bound metals were generated compared to smaller storms less than 5 mm that produced more dissolved metals. The efficiency of the systems in removing the particulate-bound metals was restricted during high average/peak flows; that is, high-intensity storms events and when heavy metals have low concentration levels.

Assessing the performances of low impact development alternatives by long-term simulation for a semi-arid area in Tianjin, northern China.

PubMed

Huang, Jinhui Jeanne; Li, Yu; Niu, Shuai; Zhou, Shu H

2014-01-01

For areas that are urbanized rapidly, the practice of low impact development (LID) has gained an important place in stormwater management and urban planning due to its capability and beneficial effects in restoring the original hydrological cycle. The performances of LID alternatives can vary substantially due to different climate conditions. This study investigated the performances of five LID alternatives under a semi-arid climate in northern China on water balance and flood control. A numerical model, Storm Water Management Model version 5 (US Environmental Protection Agency), was employed to run 10 years' rainfall events for these objectives. Two evaluation methods were proposed in this study: the efficiency index for water balance and a performance radar chart. The investigation of the five LID alternatives revealed that these LID alternatives functioned differently in flood control and water balance, and porous pavement performed best in all indices except the lag time. The two evaluation methods, in conjunction with the long-term numerical simulation, can facilitate design and decision making by providing a clear picture of the performance and functions for these LID alternatives.

Correction of lower lid retraction combined with entropion using an ear cartilage graft in the anophthalmic socket.

PubMed

Moon, Jun Woong; Choung, Ho Kyung; Khwarg, Sang In

2005-09-01

To investigate the surgical results of an ear cartilage graft and supplemental procedures for correcting lower lid retraction combined with entropion in anophthalmic patients. We reviewed retrospectively the medical records of 7 anophthalmic patients with lower lid retraction and entropion, who received a posterior lamellar ear cartilage graft and one or both of lateral tarsal strip or eyelash-everting procedure between March 1998 and March 2003. Preoperative and postoperative lid and socket statuses were also investigated. Ear cartilage grafts were performed in all 7 patients, lateral tarsal strips in 6, and eyelash-everting procedures in 5. Postoperative follow-up durations ranged from 4 to 28 months (average 12.6 months). Retractions were corrected during follow-up in all patients. There were no cases of entropion immediately after surgery. However, the eyelashes of the lower lid returned to an upright position in 4 patients, but not so severe as to touch the ocular prosthesis, and thus did not require surgical correction during follow up. Lower lid retraction combined with entropion in anophthalmic patients can be corrected effectively using an ear cartilage graft with selective, supplemental procedures.

Evaluation of low impact development approach for mitigating flood inundation at a watershed scale in China.

PubMed

Hu, Maochuan; Sayama, Takahiro; Zhang, Xingqi; Tanaka, Kenji; Takara, Kaoru; Yang, Hong

2017-05-15

Low impact development (LID) has attracted growing attention as an important approach for urban flood mitigation. Most studies evaluating LID performance for mitigating floods focus on the changes of peak flow and runoff volume. This paper assessed the performance of LID practices for mitigating flood inundation hazards as retrofitting technologies in an urbanized watershed in Nanjing, China. The findings indicate that LID practices are effective for flood inundation mitigation at the watershed scale, and especially for reducing inundated areas with a high flood hazard risk. Various scenarios of LID implementation levels can reduce total inundated areas by 2%-17% and areas with a high flood hazard level by 6%-80%. Permeable pavement shows better performance than rainwater harvesting against mitigating urban waterlogging. The most efficient scenario is combined rainwater harvesting on rooftops with a cistern capacity of 78.5 mm and permeable pavement installed on 75% of non-busy roads and other impervious surfaces. Inundation modeling is an effective approach to obtaining the information necessary to guide decision-making for designing LID practices at watershed scales. Copyright © 2017 Elsevier Ltd. All rights reserved.

Recent Developments in Ground-Borne Noise and Vibration Control

NASA Astrophysics Data System (ADS)

Nelson, J. T.

1996-05-01

Vibration control provisions available to the transit designer include (among others) precision straightened rail, ballast mats, floating slabs and very soft direct fixation fasteners, in addition to rail grinding, wheel truing, and continuous welded rail. Recently, the Los Angeles Metro has developed specifications for a soft resilient direct fixation fastener to fit the same base dimensions as the standard direct fixation fastener. In San Francisco, low resonance frequency (8 Hz) floating slabs have been constructed to mitigate predicted ground vibration impacts at nearby residential structures. In Atlanta, low resonance frequency loading slabs have been constructed to maintain a low vibration environment in a medical building planned to be built over the subway structure. In Portland and Pasadena, ballast mats have been recommended to control light rail transit ground vibration impacts on housing located at typically 35 feet from the alignment. Each of these provisions are briefly described in view of recent applications at U.S. transit systems.

Monitoring conformational heterogeneity of the lid of DnaK substrate-binding domain during its chaperone cycle.

PubMed

Banerjee, Rupa; Jayaraj, Gopal Gunanathan; Peter, Joshua Jebakumar; Kumar, Vignesh; Mapa, Koyeli

2016-08-01

DnaK or Hsp70 of Escherichia coli is a master regulator of the bacterial proteostasis network. Allosteric communication between the two functional domains of DnaK, the N-terminal nucleotide-binding domain (NBD) and the C-terminal substrate- or peptide-binding domain (SBD) regulate its activity. X-ray crystallography and NMR studies have provided snapshots of distinct conformations of Hsp70 proteins in various physiological states; however, the conformational heterogeneity and dynamics of allostery-driven Hsp70 activity remains underexplored. In this work, we employed single-molecule Förster resonance energy transfer (sm-FRET) measurements to capture distinct intradomain conformational states of a region within the DnaK-SBD known as the lid. Our data conclusively demonstrate prominent conformational heterogeneity of the DnaK lid in ADP-bound states; in contrast, the ATP-bound open conformations are homogeneous. Interestingly, a nonhydrolysable ATP analogue, AMP-PNP, imparts heterogeneity to the lid conformations mimicking the ADP-bound state. The cochaperone DnaJ confers ADP-like heterogeneous lid conformations to DnaK, although the presence of the cochaperone accelerates the substrate-binding rate by a hitherto unknown mechanism. Irrespective of the presence of DnaJ, binding of a peptide substrate to the DnaK-SBD leads to prominent lid closure. Lid closure is only partial upon binding to molten globule-like authentic cellular substrates, probably to accommodate non-native substrate proteins of varied structures. © 2016 Federation of European Biochemical Societies.

The Crystal Structure Analysis of Group B Streptococcus Sortase C1: A Model for the ;Lid; Movement upon Substrate Binding

DOE Office of Scientific and Technical Information (OSTI.GOV)

Khare, Baldeep; Fu, Zheng-Qing; Huang, I-Hsiu

2012-02-07

A unique feature of the class-C-type sortases, enzymes essential for Gram-positive pilus biogenesis, is the presence of a flexible 'lid' anchored in the active site. However, the mechanistic details of the 'lid' displacement, suggested to be a critical prelude for enzyme catalysis, are not yet known. This is partly due to the absence of enzyme-substrate and enzyme-inhibitor complex crystal structures. We have recently described the crystal structures of the Streptococcus agalactiae SAG2603 V/R sortase SrtC1 in two space groups (type II and type III) and that of its 'lid' mutant and proposed a role of the 'lid' as a protectormore » of the active-site hydrophobic environment. Here, we report the crystal structures of SAG2603 V/R sortase C1 in a different space group (type I) and that of its complex with a small-molecule cysteine protease inhibitor. We observe that the catalytic Cys residue is covalently linked to the small-molecule inhibitor without lid displacement. However, the type I structure provides a view of the sortase SrtC1 lid displacement while having structural elements similar to a substrate sorting motif suitably positioned in the active site. We propose that these major conformational changes seen in the presence of a substrate mimic in the active site may represent universal features of class C sortase substrate recognition and enzyme activation.« less

Formation of cratonic lithosphere during the initiation of plate tectonics

NASA Astrophysics Data System (ADS)

Moresi, L. N.; Beall, A.; Cooper, C. M.

2017-12-01

The Earth's oldest near-surface material, the cratonic crust, is typically underlain by unusually thick Archean lithosphere (<300 km). This cratonic lithosphere likely thickened in a high compressional stress environment. Mantle convection in the hotter Archean Earth would have imparted relatively low stresses on the lithosphere, whether or not tectonics was operating, so a high stress signal from the early Earth is paradoxical. We propose that a rapid transition, from a stagnant lid Earth to the onset of plate tectonics, generated the high stresses required to thicken the cratonic lithosphere. Numerical calculations are used to demonstrate that an existing buoyant and strong layer, representing harzburgite and felsic crust, can thicken and stabilize during the lid-breaking event. The peak compressional stress experienced by lithosphere is 3-4 higher than for the stagnant lid or mobile lid regimes immediately before and after. It is plausible that the cratonic lithosphere has still not returned to this high stress-state, explaining its stability. The lid-breaking thickening event reproduces craton features previously attributed to subduction: thrust structures, assembled crustal fragments and transport of basaltic upper crust to depths required to generate felsic melt. Palaeoarchean `pre-tectonic' structures can also survive the lid-breaking event, acting as strong crustal rafts. Together, the results indicate that the signature of a catastrophic switch, from a stagnant lid Earth to the initiation of plate tectonics, has been captured and preserved in the unusual characteristics of cratonic crust and lithosphere.

Multiple-camera tracking: UK government requirements

NASA Astrophysics Data System (ADS)

Hosmer, Paul

2007-10-01

The Imagery Library for Intelligent Detection Systems (i-LIDS) is the UK government's new standard for Video Based Detection Systems (VBDS). The standard was launched in November 2006 and evaluations against it began in July 2007. With the first four i-LIDS scenarios completed, the Home Office Scientific development Branch (HOSDB) are looking toward the future of intelligent vision in the security surveillance market by adding a fifth scenario to the standard. The fifth i-LIDS scenario will concentrate on the development, testing and evaluation of systems for the tracking of people across multiple cameras. HOSDB and the Centre for the Protection of National Infrastructure (CPNI) identified a requirement to track targets across a network of CCTV cameras using both live and post event imagery. The Detection and Vision Systems group at HOSDB were asked to determine the current state of the market and develop an in-depth Operational Requirement (OR) based on government end user requirements. Using this OR the i-LIDS team will develop a full i-LIDS scenario to aid the machine vision community in its development of multi-camera tracking systems. By defining a requirement for multi-camera tracking and building this into the i-LIDS standard the UK government will provide a widely available tool that developers can use to help them turn theory and conceptual demonstrators into front line application. This paper will briefly describe the i-LIDS project and then detail the work conducted in building the new tracking aspect of the standard.

Searching for Hysteresis in Models of Mantle Convection with Grain-Damage

NASA Astrophysics Data System (ADS)

Lamichhane, R.; Foley, B. J.

2017-12-01

The mode of surface tectonics on terrestrial planets is determined by whether mantle convective forces are capable of forming weak zones of localized deformation in the lithosphere, which act as plate boundaries. If plate boundaries can form then a plate tectonic mode develops, and if not convection will be in the stagnant lid regime. Episodic subduction or sluggish lid convection are also possible in between the nominal plate tectonic and stagnant lid regimes. Plate boundary formation is largely a function of the state of the mantle, e.g. mantle temperature or surface temperature, and how these conditions influence both mantle convection and the mantle rheology's propensity for forming weak, localized plate boundaries. However, a planet's tectonic mode also influences whether plate boundaries can form, as the driving forces for plate boundary formation (e.g. stress and viscous dissipation) are different in a plate tectonic versus stagnant lid regime. As a result, tectonic mode can display hysteresis, where convection under otherwise identical conditions can reach different final states as a result of the initial regime of convection. Previous work has explored this effect in pseudoplastic models, finding that it is more difficult to initiate plate tectonics starting from a stagnant lid state than it is to sustain plate tectonics when already in a mobile lid regime, because convective stresses in the lithosphere are lower in a stagnant lid regime than in a plate tectonic regime. However, whether and to what extent such hysteresis is displayed when alternative rheological models for lithospheric shear localization are used is unknown. In particular, grainsize reduction is commonly hypothesized to be a primary cause of shear localization and plate boundary formation. We use new models of mantle convection with grain-size evolution to determine how the initial mode of surface tectonics influences the final convective regime reached when convection reaches statistical steady-state. Scaling analysis is performed to quantify how subduction initiation from a stagnant lid differs from sustaining subduction in a mobile lid. The implications of our results for the evolution of the mode of surface tectonics on terrestrial planets will also be discussed.

Large-scale environmental degradation results in inequitable impacts to already impoverished communities: A case study from the floating villages of Cambodia.

PubMed

Althor, Glenn; Mahood, Simon; Witt, Bradd; Colvin, Rebecca M; Watson, James E M

2018-02-19

Cambodian subsistence communities within the Tonle Sap Great Lake area rely on resource extraction from the lake to meet livelihood needs. These fishing communities-many of which consist of dwellings floating on the lake-face potentially profound livelihood challenges because of climate change and changing hydrology due to dam construction for hydroelectricity within the Mekong Basin. We conducted interviews across five village communities, with local subsistence fisher people in the Tonle Sap in 2015, and used thematic analysis methods to reveal a fishery system that is undergoing rapid ecological decline, with local fishing communities increasingly experiencing reductions in available fish stocks. As a result, over 100 000 people living in these communities are experiencing a direct loss of well-being and livelihood. We discuss these losses and consider their implications for the future viability of Cambodian floating village communities.

An inexpensive instrument for measuring wave exposure and water velocity

USGS Publications Warehouse

Figurski, J.D.; Malone, D.; Lacy, J.R.; Denny, M.

2011-01-01

Ocean waves drive a wide variety of nearshore physical processes, structuring entire ecosystems through their direct and indirect effects on the settlement, behavior, and survivorship of marine organisms. However, wave exposure remains difficult and expensive to measure. Here, we report on an inexpensive and easily constructed instrument for measuring wave-induced water velocities. The underwater relative swell kinetics instrument (URSKI) is a subsurface float tethered by a short (<1 m) line to the seafloor. Contained within the float is an accelerometer that records the tilt of the float in response to passing waves. During two field trials totaling 358 h, we confirmed the accuracy and precision of URSKI measurements through comparison to velocities measured by an in situ acoustic Doppler velocimeter and those predicted by a standard swell model, and we evaluated how the dimensions of the devices, its buoyancy, and sampling frequency can be modified for use in a variety of environments.

Floating Offshore Wind in Hawaii: Potential for Jobs and Economic Impacts from Three Future Scenarios

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jimenez, Tony; Keyser, David; Tegen, Suzanne

Construction of the first offshore wind power plant in the United States began in 2015, off the coast of Rhode Island, using fixed platform structures that are appropriate for shallow seafloors, like those located off the East Coast and mid-Atlantic. However, floating platforms, which have yet to be deployed commercially, will likely need to be anchored to the deeper seafloor if deployed in Hawaiian waters. To analyze the employment and economic potential for floating offshore wind off Hawaii's coasts, the Bureau of Ocean Energy Management commissioned the National Renewable Energy Laboratory (NREL) to analyze two hypothetical deployment scenarios for Hawaii:more » 400 MW of offshore wind by 2050 and 800 MW of offshore wind by 2050. The results of this analysis can be used to better understand the general scale of economic opportunities that could result from offshore wind development.« less

Thin film construction and characterization and gas-sensing performances of a tailored phenylene-thienylene copolymer.

PubMed

Naso, Francesco; Babudri, Francesco; Colangiuli, Donato; Farinola, Gianluca M; Quaranta, Fabio; Rella, Roberto; Tafuro, Raffaele; Valli, Ludovico

2003-07-30

An alternating copolymer, poly(2,5-dioctyloxy-1,4-phenylene-alt-2,5-thienylene), has been synthesized and used in this research. The behavior of the floating film at the air-water interface has been investigated by measuring surface pressure versus area Langmuir isotherms and contemporaneously by reflection spectroscopy and Brewster angle microscopy. The floating films were transferred by the Langmuir-Schäfer (horizontal lifting) method onto various substrates. It is apparent from these analyses that the effective conjugation length is larger than those in other electroactive polymers and that a strong coplanarity and interchain association takes place above all in the floating film on the water surface and in the transferred multilayers. Such films were used as the active layers in resistive chemical gas sensor devices, thus revealing excellent sensitivity toward NO(2), reversibility, and time stability of the response.

ISS Plasma Interaction: Measurements and Modeling

NASA Technical Reports Server (NTRS)

Barsamian, H.; Mikatarian, R.; Alred, J.; Minow, J.; Koontz, S.

2004-01-01

Ionospheric plasma interaction effects on the International Space Station are discussed in the following paper. The large structure and high voltage arrays of the ISS represent a complex system interacting with LEO plasma. Discharge current measurements made by the Plasma Contactor Units and potential measurements made by the Floating Potential Probe delineate charging and magnetic induction effects on the ISS. Based on theoretical and physical understanding of the interaction phenomena, a model of ISS plasma interaction has been developed. The model includes magnetic induction effects, interaction of the high voltage solar arrays with ionospheric plasma, and accounts for other conductive areas on the ISS. Based on these phenomena, the Plasma Interaction Model has been developed. Limited verification of the model has been performed by comparison of Floating Potential Probe measurement data to simulations. The ISS plasma interaction model will be further tested and verified as measurements from the Floating Potential Measurement Unit become available, and construction of the ISS continues.

Evaluation of reef shell embankment : final report.

DOT National Transportation Integrated Search

1980-12-01

This report discusses a method of constructing an embankment over marshland soils by end-dumping reef shell directly onto the marshland with no other major subgrade preparation. The dumped reef shell is then spread out to form a "floating" embankment...

Floating-Point Units and Algorithms for field-programmable gate arrays

DOE Office of Scientific and Technical Information (OSTI.GOV)

Underwood, Keith D.; Hemmert, K. Scott

2005-11-01

The software that we are attempting to copyright is a package of floating-point unit descriptions and example algorithm implementations using those units for use in FPGAs. The floating point units are best-in-class implementations of add, multiply, divide, and square root floating-point operations. The algorithm implementations are sample (not highly flexible) implementations of FFT, matrix multiply, matrix vector multiply, and dot product. Together, one could think of the collection as an implementation of parts of the BLAS library or something similar to the FFTW packages (without the flexibility) for FPGAs. Results from this work has been published multiple times and wemore » are working on a publication to discuss the techniques we use to implement the floating-point units, For some more background, FPGAS are programmable hardware. "Programs" for this hardware are typically created using a hardware description language (examples include Verilog, VHDL, and JHDL). Our floating-point unit descriptions are written in JHDL, which allows them to include placement constraints that make them highly optimized relative to some other implementations of floating-point units. Many vendors (Nallatech from the UK, SRC Computers in the US) have similar implementations, but our implementations seem to be somewhat higher performance. Our algorithm implementations are written in VHDL and models of the floating-point units are provided in VHDL as well. FPGA "programs" make multiple "calls" (hardware instantiations) to libraries of intellectual property (IP), such as the floating-point unit library described here. These programs are then compiled using a tool called a synthesizer (such as a tool from Synplicity, Inc.). The compiled file is a netlist of gates and flip-flops. This netlist is then mapped to a particular type of FPGA by a mapper and then a place- and-route tool. These tools assign the gates in the netlist to specific locations on the specific type of FPGA chip used and constructs the required routes between them. The result is a "bitstream" that is analogous to a compiled binary. The bitstream is loaded into the FPGA to create a specific hardware configuration.« less

Variations in Nutrient Cycling and Meltwater Composition Between Ice-Lidded and Open System Cryoconites

NASA Astrophysics Data System (ADS)

Mass, A.

2016-12-01

Cryoconites are small melt pools on the ablation surface of glaciers created by the accumulation of aeolian sediment with a lower albedo than the surrounding ice. While many cryoconites remain open to the surrounding atmosphere, environmental conditions in the McMurdo Dry Valleys of Antarctica often lead to the formation of dense ice lids due to advection from cold winds. These lidded cryoconites are isolated from atmospheric exchange while maintaining subsurface melt in a solid-state greenhouse. The varying conditions for the formation and freeze-thaw cycle of cryoconites lead to a range of biogeochemical processes occurring within the pools. This study analyzed the biochemistry of both open and lidded cryoconite water from six glaciers in the Dry Valleys throughout the initial pulse melt, equilibrium, and refreezing periods in 2013- 2015. Many of the spatial gradients in carbon cycling, solute concentrations, and pH identified for lidded cryoconites exhibited opposite trends for pools in equilibrium with the atmosphere, while temporal gradients were less diverse for open pools.

Unveiling the nucleon tensor charge at Jefferson Lab: A study of the SoLID case

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ye, Zhihong; Sato, Nobuo; Allada, Kalyan

© 2017 The Authors Future experiments at the Jefferson Lab 12 GeV upgrade, in particular, the Solenoidal Large Intensity Device (SoLID), aim at a very precise data set in the region where the partonic structure of the nucleon is dominated by the valence quarks. One of the main goals is to constrain the quark transversity distributions. We apply recent theoretical advances of the global QCD extraction of the transversity distributions to study the impact of future experimental data from the SoLID experiments. Especially, we develop a simple strategy based on the Hessian matrix analysis that allows one to estimate themore » uncertainties of the transversity quark distributions and their tensor charges extracted from SoLID data simulation. We find that the SoLID measurements with the proton and the effective neutron targets can improve the precision of the u- and d-quark transversity distributions up to one order of magnitude in the range 0.05 < x < 0.6.« less

Analysis on LID for highly urbanized areas' waterlogging control: demonstrated on the example of Caohejing in Shanghai.

PubMed

Liao, Z L; He, Y; Huang, F; Wang, S; Li, H Z

2013-01-01

Although a commonly applied measure across the United States and Europe for alleviating the negative impacts of urbanization on the hydrological cycle, low impact development (LID) has not been widely used in highly urbanized areas, especially in rapidly urbanizing cities in developing countries like China. In this paper, given five LID practices including Bio-Retention, Infiltration Trench, Porous Pavement, Rain Barrels, and Green Swale, an analysis on LID for highly urbanized areas' waterlogging control is demonstrated using the example of Caohejing in Shanghai, China. Design storm events and storm water management models are employed to simulate the total waterlogging volume reduction, peak flow rate reduction and runoff coefficient reduction of different scenarios. Cost-effectiveness is calculated for the five practices. The aftermath shows that LID practices can have significant effects on storm water management in a highly urbanized area, and the comparative results reveal that Rain Barrels and Infiltration Trench are the two most suitable cost-effective measures for the study area.

Unveiling the nucleon tensor charge at Jefferson Lab: A study of the SoLID case

NASA Astrophysics Data System (ADS)

Ye, Zhihong; Sato, Nobuo; Allada, Kalyan; Liu, Tianbo; Chen, Jian-Ping; Gao, Haiyan; Kang, Zhong-Bo; Prokudin, Alexei; Sun, Peng; Yuan, Feng

2017-04-01

Future experiments at the Jefferson Lab 12 GeV upgrade, in particular, the Solenoidal Large Intensity Device (SoLID), aim at a very precise data set in the region where the partonic structure of the nucleon is dominated by the valence quarks. One of the main goals is to constrain the quark transversity distributions. We apply recent theoretical advances of the global QCD extraction of the transversity distributions to study the impact of future experimental data from the SoLID experiments. Especially, we develop a simple strategy based on the Hessian matrix analysis that allows one to estimate the uncertainties of the transversity quark distributions and their tensor charges extracted from SoLID data simulation. We find that the SoLID measurements with the proton and the effective neutron targets can improve the precision of the u- and d-quark transversity distributions up to one order of magnitude in the range 0.05 < x < 0.6.

Nuclear fuel pellet sintering boat unloading apparatus and method

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huggins, T.B.; Widener, W.H.; Klapper, K.K.

1990-05-22

This patent describes a method for unloading nuclear fuel pellets from a sintering boat having an open top. It comprises: pivoting a transfer housing loaded with the boat filled with nuclear fuel pellets about a generally horizontal axis from an upright position remote from a pellet deposit surface to an inverted position adjacent to the deposit surface to move the boat from an upright to inverted orientation with the pellets retained within the boat by a latched lid in a closed condition on the housing; unlatching the lid of the housing as the housing reaches its inverted position but engagingmore » the unlatched lid with the deposit surface to retain it in its closed condition; and reverse pivoting the housing from its inverted position back toward its upright position to permit the unlatched lid to pivot from the closed condition to an opened condition thereby allowing pellets to slide out of the open top of the inverted boat and down the opened lid of the housing to the deposit site.« less

Managing the Lower Eyelid Complex in the Thick-Skinned Patient.

PubMed

Floyd, Elizabeth Mia; Perkins, Stephen W

2018-02-01

Thick skin presents a unique set of challenges within the realm of facial plastic surgery, and addressing the lower lid complex is no exception. There are several procedures for addressing the lower lids, the first and foremost being lower lid blepharoplasty. However, the remaining procedures combined with surgical techniques have exclusive implications in thick skin. Understanding the anatomy and various techniques that can be applied to thick skin can help achieve aesthetically more pleasing results in comparison to those of thin skin. As will be discussed in this article, patients with skin color of Fitzpatrick's grade III or higher have several characteristics associated with their skin, including thicker dermis as well as different patterns of aging, which have implications for addressing the lower lid complex. The senior author has extensive experience performing lower lid procedures and seeks to impart how best to understand and adapt for these differences to allow for the best aesthetic result. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

The SoLid experiment

NASA Astrophysics Data System (ADS)

Kalousis, L. N.; SoLid Collaboration

2017-09-01

The SoLid experiment is a short-baseline project, probing the disappearance of reactor antineutrinos using a novel detector design. Installed at a very short distance of ˜ 5.5 - 10 m from the BR2 research reactor at SCK·CEN in Mol (Belgium) it will be able to search for active-to-sterile neutrino oscillations, exploring most of the allowed parameter region. SoLid will make use of a highly segmented detector, built from 5 cm PVT cubes, interleaved with 6LiF:ZnS(Ag) screens, and read out by optical fibers and Silicon Photomultipliers (SiPMs). The detector granularity allows for the localization of the positron and neutron signals from antineutrino interactions and the robust neutron identification capabilities, offered by the 6LiF:ZnS(Ag) inorganic scintillator, provide background suppression to an unparalleled level. This paper reviews the experimental layout and current status of SoLid. Emphasis is put on the challenges one faces towards this measurement, focusing on the decisions and strategy adapted by the SoLid collaboration. The analysis scheme and the details of the oscillation framework are also presented, highlighting the sensitivity contour and physics potential of SoLid. Finally, other physics topics, such as, reactor monitoring or measurement of the 235U spectrum are also covered.

Specialty Care Delivery: Bringing Infectious Disease Expertise to the Residents of a Veterans Affairs Long-Term Care Facility

PubMed Central

Jump, Robin L. P.; Olds, Danielle M.; Jury, Lucy A.; Sitzlar, Brett; Saade, Elie; Watts, Brook; Bonomo, Robert A.; Donskey, Curtis J.

2013-01-01

Background Residents of long-term care facilities (LTCFs) are a population vulnerable to infections and to the adverse effects of inappropriate antimicrobial prescribing. To improve the care of residents with possible infections, we initiated a LTCF Infectious Disease (LID) service that provides on-site consultations to LTCF residents. Design Clinical demonstration project Setting A 160-bed LTCF affiliated with a tertiary care Veterans Affairs (VA) hospital. Participants Residents referred to the LID Team. Measurements The reason for and source of LTCF residents’ referral to the LID team as well as their demographics, infectious disease diagnoses, interventions and hospitalizations were determined. Results Between July 2009 and December 2010, the LID consult service provided 291 consults for 250 LTCF residents. Referrals came from either the LTCF staff (75%) or the VA hospital’s ID consult service (25%). The most common diagnoses were Clostridium difficile infection (14%), asymptomatic bacteriuria (10%), and urinary tract infection (10%). More than half of referred patients were on antibiotic therapy when first seen by the LID team; 46% of patients required an intervention. The most common interventions, stopping (32%) or starting (26%) antibiotics, were made in accordance with principles of antibiotic stewardship. Conclusion The LID team represents a novel and effective means to bring subspecialty care to LTCF residents. PMID:23590125

National Stormwater Calculator: Low Impact Development ...

EPA Pesticide Factsheets

The National Stormwater Calculator (NSC) makes it easy to estimate runoff reduction when planning a new development or redevelopment site with low impact development (LID) stormwater controls. The Calculator is currently deployed as a Windows desktop application. The Calculator is organized as a wizard style application that walks the user through the steps necessary to perform runoff calculations on a single urban sub-catchment of 10 acres or less in size. Using an interactive map, the user can select the sub-catchment location and the Calculator automatically acquires hydrologic data for the site.A new LID cost estimation module has been developed for the Calculator. This project involved programming cost curves into the existing Calculator desktop application. The integration of cost components of LID controls into the Calculator increases functionality and will promote greater use of the Calculator as a stormwater management and evaluation tool. The addition of the cost estimation module allows planners and managers to evaluate LID controls based on comparison of project cost estimates and predicted LID control performance. Cost estimation is accomplished based on user-identified size (or auto-sizing based on achieving volume control or treatment of a defined design storm), configuration of the LID control infrastructure, and other key project and site-specific variables, including whether the project is being applied as part of new development or redevelopm

Development of a Tool for Siting Low Impact Development in Urban Watersheds

NASA Astrophysics Data System (ADS)

Martin-Mikle, C.; de Beurs, K.; Julian, J.

2013-12-01

Low impact development (LID) -- a comprehensive land use planning and design approach with the goal of mitigating development impacts on hydrologic/nutrient cycles and ecosystems -- is increasingly being touted as an effective approach to lessen overland runoff and pollutant loadings. Examples of LIDs include riparian buffers, grassed swales, detention/retention ponds, rain gardens, green roofs and rain barrels. Broad-scale decision support tools for siting LIDs have been developed for agricultural watersheds, but are rare for urban watersheds, largely due to greater land use complexity and lack of necessary high-resolution geospatial data. Here, we develop a framework to assist city planners and water quality managers in siting LIDs in urban watersheds. One key component of this research is a framework accessible to those interested in using it. Hence, development of the framework has centered around 1) determining optimal data requirements for siting LID in an urban watershed and 2) developing a tool compatible with both open-source and commercial GIS software. We employ a wide variety of landscape metrics to evaluate the tool. A case study of the Lake Thunderbird Watershed, an urbanized watershed southeast of Oklahoma City, illustrates the effectiveness of a tool that is capable of siting LID in an urban watershed.

Low Impact Docking System (LIDS)

NASA Technical Reports Server (NTRS)

LaBauve, Tobie E.

2009-01-01

Since 1996, NASA has been developing a docking system that will simplify operations and reduce risks associated with mating spacecraft. This effort has focused on developing and testing an original, reconfigurable, active, closed-loop, force-feedback controlled docking system using modern technologies. The primary objective of this effort has been to design a docking interface that is tunable to the unique performance requirements for all types of mating operations (i.e. docking and berthing, autonomous and piloted rendezvous, and in-space assembly of vehicles, modules and structures). The docking system must also support the transfer of crew, cargo, power, fluid, and data. As a result of the past 10 years of docking system advancement, the Low Impact Docking System or LIDS was developed. The current LIDS design incorporates the lessons learned and development experiences from both previous and existing docking systems. LIDS feasibility was established through multiple iterations of prototype hardware development and testing. Benefits of LIDS include safe, low impact mating operations, more effective and flexible mission implementation with an anytime/anywhere mating capability, system level redundancy, and a more affordable and sustainable mission architecture with reduced mission and life cycle costs. In 1996 the LIDS project, then known as the Advanced Docking Berthing System (ADBS) project, launched a four year developmental period. At the end of the four years, the team had built a prototype of the soft-capture hardware and verified the control system that will be used to control the soft-capture system. In 2001, the LIDS team was tasked to work with the X- 38 Crew Return Vehicle (CRV) project and build its first Engineering Development Unit (EDU).

Structure of Human Pancreatic Lipase-Related Protein 2 with the Lid in an Open Conformation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eydoux, Cecilia; Spinelli, Silvia; Davis, Tara L.

2008-10-02

Access to the active site of pancreatic lipase (PL) is controlled by a surface loop, the lid, which normally undergoes conformational changes only upon addition of lipids or amphiphiles. Structures of PL with their lids in the open and functional conformation have required cocrystallization with amphiphiles. Here we report two crystal structures of wild-type and unglycosylated human pancreatic lipase-related protein 2 (HPLRP2) with the lid in an open conformation in the absence of amphiphiles. These structures solved independently are strikingly similar, with some residues of the lid being poorly defined in the electron-density map. The open conformation of the lidmore » is however different from that previously observed in classical liganded PL, suggesting different kinetic properties for HPLRP2. Here we show that the HPLRP2 is directly inhibited by E600, does not present interfacial activation, and acts preferentially on substrates forming monomers or small aggregates (micelles) dispersed in solution like monoglycerides, phospholipids and galactolipids, whereas classical PL displays reverse properties and a high specificity for unsoluble substrates like triglycerides and diglycerides forming oil-in-water interfaces. These biochemical properties imply that the lid of HPLRP2 is likely to spontaneously adopt in solution the open conformation observed in the crystal structure. This open conformation generates a large cavity capable of accommodating the digalactose polar head of galactolipids, similar to that previously observed in the active site of the guinea pig PLRP2, but absent from the classical PL. Most of the structural and kinetic properties of HPLRP2 were found to be different from those of rat PLRP2, the structure of which was previously obtained with the lid in a closed conformation. Our findings illustrate the essential role of the lid in determining the substrate specificity and the mechanism of action of lipases.« less

[Correlation of insulin-like growth factor-1 (IGF-1) to angiogenesis of breast cancer in IGF-1-deficient mice].

PubMed

Tang, Hong-Bo; Ren, Yu-Ping; Zhang, Jun; Ma, Shi-Hui; Gao, Feng; Wu, Yi-Ping

2007-11-01

Insulin-like growth factors (IGFs) play important roles in the development and progression of tumors. But the mechanism of tumorigenesis in relation to IGF-1 is unclear yet. This study was to explore the correlation of circulating IGF-1 level to the angiogenesis of breast cancer in IGF-1-deficient mice. The liver-specific IGF-1-deficient (LID) mice and control mice were injected with 7,12-dimethybenz(a)anthracene (DMBA) to develop breast cancer. Ginsenoside Rg3 was used to intervene tumor growth. The occurrence rates of breast cancer were compared. The expression of vascular endothelial growth factor (VEGF) and microvessel density (MVD) was detected by immunohistochemistry. The occurrence rate of breast cancer was 66.67% in untreated control mice, 33.33% in untreated LID mice, 36.00% in Rg3-treated control mice, and 12.00% in Rg3-treated LID mice. The tumor size was (0.79+/-0.20) cm in untreated control mice, (0.37+/-0.08) cm in untreated LID mice, (0.32+/-0.08) cm in Rg3-treated control mice, and (0.15+/-0.05) cm in Rg3-treated LID mice. The average light density and positive rate of VEGF were the highest in untreated control mice (0.34+/-0.10 and 0.04+/-0.02, P<0.05), and the lowest in Rg3-treated LID mice (0.13+/-0.03 and 0.01+/-0.00, P<0.05). The MVD was 31.9+/-5.3 in untreated control mice, 26.8+/-4.9 in untreated LID mice, 20.1+/-4.9 in Rg3-treated control mice, and 14.4+/-4.9 in Rg3-treated LID mice. Circulating IGF-1 plays a role in the onset and development of breast cancer. Degrading serum IGF-1 level could inhibit angiogenesis and growth of breast cancer. Rg3 could promote this effect.

Growth hormone mediates pubertal skeletal development independent of hepatic IGF-1 production.

PubMed

Courtland, Hayden-William; Sun, Hui; Beth-On, Mordechay; Wu, Yingjie; Elis, Sebastien; Rosen, Clifford J; Yakar, Shoshana

2011-04-01

Deficiencies in either growth hormone (GH) or insulin-like growth factor 1 (IGF-1) are associated with reductions in bone size during growth in humans and animal models. Liver-specific IGF-1-deficient (LID) mice, which have 75% reductions in serum IGF-1, were created previously to separate the effects of endocrine (serum) IGF-1 from autocrine/paracrine IGF-1. However, LID mice also have two- to threefold increases in GH, and this may contribute to the observed pubertal skeletal phenotype. To clarify the role of GH in skeletal development under conditions of significantly reduced serum IGF-1 levels (but normal tissue IGF-1 levels), we studied the skeletal response of male LID and control mice to GH inhibition by pegvisomant from 4 to 8 weeks of age. Treatment of LID mice with pegvisomant resulted in significant reductions in body weight, femur length (Le), and femur total area (Tt.Ar), as well as further reductions in serum IGF-1 levels by 8 weeks of age, compared with the mean values of vehicle-treated LID mice. Reductions in both Tt.Ar and Le were proportional after treatment with pegvisomant. On the other hand, the relative amount of cortical tissue formed (RCA) in LID mice treated with pegvisomant was significantly less than that in both vehicle-treated LID and control mice, indicating that antagonizing GH action, either directly (through GH receptor signaling inhibition) or indirectly (through further reductions in serum/tissue IGF-1 levels), results in disproportionate reductions in the amount of cortical bone formed. This resulted in bones with significantly reduced mechanical properties (femoral whole-bone stiffness and work to failure were markedly decreased), suggesting that compensatory increases of GH in states of IGF-1 deficiency (LID mice) act to protect against a severe inhibition of bone modeling during growth, which otherwise would result in bones that are too weak for normal and/or extreme loading conditions. Copyright © 2011 American Society for Bone and Mineral Research.

Convection in Icy Satellites: Implications for Habitability and Planetary Protection

NASA Technical Reports Server (NTRS)

Barr, A. C.; Pappalardo, R. T.

2004-01-01

Solid-state convection and endogenic resurfacing in the outer ice shells of the icy Galilean satellites (especially Europa) may contribute to the habitability of their internal oceans and to the detectability of any biospheres by spacecraft. If convection occurs in an ice I layer, fluid motions are confined beneath a thick stagnant lid of cold, immobile ice that is too stiff to participate in convection. The thickness of the stagnant lid varies from 30 to 50% of the total thickness of the ice shell, depending on the grain size of ice. Upward convective motions deliver approximately 10(exp 9) to 10(exp 13) kg yr(sup -1) of ice to the base of the stagnant lid, where resurfacing events driven by compositional or tidal effects (such as the formation of domes or ridges on Europa, or formation of grooved terrain on Ganymede) may deliver materials from the stagnant lid onto the surface. Conversely, downward convective motions deliver the same mass of ice from the base of the stagnant lid to the bottom of the satellites ice shells. Materials from the satellites surfaces may be delivered to their oceans by downward convective motions if material from the surface can reach the base of the stagnant lid during resurfacing events. Triggering convection from an initially conductive ice shell requires modest amplitude (a few to tens of kelvins) temperature anomalies to soften the ice to permit convection, which may require tidal heating. Therefore, tidal heating, compositional buoyancy, and solid-state convection in combination may be required to permit mass transport between the surfaces and oceans of icy satellites. Callisto and probably Ganymede have thick stagnant lids with geologically inactive surfaces today, so forward contamination of their surfaces is not a significant issue. Active convection and breaching of the stagnant lid is a possibility on Europa today, so is of relevance to planetary protection policy.

Closed and open conformations of the lid domain induce different patterns of human pancreatic lipase antigenicity and immunogenicity.

PubMed

Halimi, Hubert; De Caro, Josiane; Carrière, Frédéric; De Caro, Alain

2005-12-01

Epitope mapping was performed on human pancreatic lipase (HPL) using the SPOTscan method. A set of 146 short (12 amino acid residues) synthetic overlapping peptides covering the entire amino acid sequence of HPL were used to systematically assess the immunoreactivity of antisera raised in rabbits against native HPL, HPL without a lid (HPL(-lid)) and HPL covalently inhibited by diethyl p-nitrophenyl phosphate (DP-HPL). In the latter form of HPL, the lid domain controlling the access to the active site was assumed to exist in the open conformation. All the anti-lipase sera were tested in a direct ELISA, anti-HPL serum showing the greatest antibody titer. Although from the structural point of view, the differences between the various forms of HPL were restricted to the lid domain, differences in the antigenic properties of HPL were observed with the SPOTscan method, and the anti-DP-HPL antibodies showed the strongest reactivity. Most of the peptide stretches recognized included amino acid residues which are accessible at the surface of the lipase, except for those located near the active site. Two small peptides (T173-P180, V199-A207) were identified in the vicinity of the active site, their antipeptide antibodies were produced and their reactivity towards the various forms of HPL was tested in a double sandwich ELISA. No reactivity was observed under these conditions. Two antipeptide antibodies directed against two other selected peptides, P208-V221 (belonging to the beta9 loop) and I245-F258 (belonging to the lid domain) were prepared and found to react much more strongly with DP-HPL than with HPL or HPL(-lid) in a double sandwich ELISA. These antibodies should provide useful tools for monitoring the conformational changes taking place during the opening of the HPL lid domain.

TEST CELL STUDIES OF RADON ENTRY

EPA Science Inventory

The report gives results of a study to contrast the effectiveness of slab-in-stem wall (SSW) with floating slab (FS) construction practices, to measure radon transport and entry for model testing, to develop protocols relevant to depressurized radon measurements, and to determine...

Fast orthogonal transforms and generation of Brownian paths

PubMed Central

Leobacher, Gunther

2012-01-01

We present a number of fast constructions of discrete Brownian paths that can be used as alternatives to principal component analysis and Brownian bridge for stratified Monte Carlo and quasi-Monte Carlo. By fast we mean that a path of length n can be generated in O(nlog(n)) floating point operations. We highlight some of the connections between the different constructions and we provide some numerical examples. PMID:23471545

iLIDS Simulations and Videos for Docking TIM

NASA Technical Reports Server (NTRS)

Lewis, James L.

2010-01-01

The video shows various aspects of the International Low Impact Docking System, including team members, some production, configuration, mated androgynous iLIDS, SCS Lockdown system, thermal analysis, electrical engineering aspects, the iLIDS control box and emulator, radiation testing at BNL, component environmental testing, component vibration testing, 3G processor board delivery system, GTA vibe test, EMA testbed, hook and hook disassembly, flex shaftdrive assembly, GSE cradle MISSE-6 Columbus, MISSE 6 and 7 seal experiments, actuated full scale seal test rig, LIDS on Hubble, dynamics test prep, EDU 54 mass emulation and SCS, load ring characterization, 6DOF proof test, SCS at 6DOF, machining EEMS and inner ring assembly, APAS assembly, inner ring fitting, rotation stand assembly, EEMS mating, and EEMS proof of concept demonstration.

A 40 MWe floating OTEC plant at Punta Tuna, Puerto Rico

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dambly, B.W.

1981-01-01

A development project leading to a closed-cycle ocean thermal energy conversion (OTEC) pilot plant is considered. In connection with this project, a plan was submitted for design, construction, deployment, start-up, and operation of a 40 MWe floating electric generating plant at Punta Tuna, Puerto Rico. Attention is given to the OTEC concept, organizational aspects related to the project, the major problems regarding the OTEC program, and the commercialization plan. Questions of design philosophy are examined, taking into account the need for efficient heat exchangers, the minimization of water flow, the importance of achieving maximized efficiency, and requirements for environmental safety.

[Eyelid hygiene for contact lens wearers with blepharitis. Comparative investigation of treatment with baby shampoo versus phospholipid solution].

PubMed

Khaireddin, R; Hueber, A

2013-02-01

Blepharitis due to Meibom gland dysfunction (MGD) is presumed to be one of the main reasons for dry eye symptoms which occur in up to 50% of contact lens users. Thus, MGD presumably plays an important role in dry eye in contact lens wearers. In the present prospective, randomized and double blind trial the efficacy of two established treatment options for MGD and blepharitis was evaluated in symptomatic contact lens wearers. In this prospective, randomized 2-centre trial 53 symptomatic contact lens wearers suffering from blepharitis were included. Patients were randomly selected for two treatment groups: group A performed lid margin hygiene using the commonly recommended mild baby shampoo (Bübchen Kinder Shampoo-extra augenmild, Bübchen Werk Ewald Hermes Pharmazeutische Fabrik GmbH, Soest, Germany) and group B performed lid margin hygiene using a phospholipid-liposome solution specially designed for lid hygiene (Blepha Cura, Optima, Moosburg/Wang, Germany), each for 4 weeks. Before as well as 4 weeks after initiation of this study the following tests were performed: standardized subjective assessment using the ocular surface disease index, non-invasive break-up time (NIBUT) and objective evaluation of lid-parallel conjunctival folds (LIPCOF) and further lid margin criteria by double blinded evaluation of slit lamp photographs. Of the 53 symptomatic contact lens wearers suffering from blepharitis 21 (39,6%) were randomly selected for treatment group A and 32 (60.4%) for group B. In both treatment groups there was objective and subjective improvement of symptoms of dry eye in contact lens wearers. Interestingly, there was a significantly greater improvement, subjective as well as objective, in treatment group B which used the phospholipidliposome solution for lid margin hygiene compared to group A using baby shampoo. Although both therapies improved symptoms of dry eye due to blepharitis in symptomatic contact lens wearers, patients using phospholipid-liposomal solution for lid margin hygiene demonstrated a significantly greater clinical benefit from the therapy. Thus, clinical practice recommending just baby shampoo for lid margin hygiene should be re-considered, as phospholipid-liposomal solution for lid margin hygiene appears to yield greater and faster clinical benefits for symptomatic contact lens wearers suffering from dry eye symptoms.

Base-CP proteasome can serve as a platform for stepwise lid formation

PubMed Central

Yu, Zanlin; Livnat-Levanon, Nurit; Kleifeld, Oded; Mansour, Wissam; Nakasone, Mark A.; Castaneda, Carlos A.; Dixon, Emma K.; Fushman, David; Reis, Noa; Pick, Elah; Glickman, Michael H.

2015-01-01

26S proteasome, a major regulatory protease in eukaryotes, consists of a 20S proteolytic core particle (CP) capped by a 19S regulatory particle (RP). The 19S RP is divisible into base and lid sub-complexes. Even within the lid, subunits have been demarcated into two modules: module 1 (Rpn5, Rpn6, Rpn8, Rpn9 and Rpn11), which interacts with both CP and base sub-complexes and module 2 (Rpn3, Rpn7, Rpn12 and Rpn15) that is attached mainly to module 1. We now show that suppression of RPN11 expression halted lid assembly yet enabled the base and 20S CP to pre-assemble and form a base-CP. A key role for Regulatory particle non-ATPase 11 (Rpn11) in bridging lid module 1 and module 2 subunits together is inferred from observing defective proteasomes in rpn11–m1, a mutant expressing a truncated form of Rpn11 and displaying mitochondrial phenotypes. An incomplete lid made up of five module 1 subunits attached to base-CP was identified in proteasomes isolated from this mutant. Re-introducing the C-terminal portion of Rpn11 enabled recruitment of missing module 2 subunits. In vitro, module 1 was reconstituted stepwise, initiated by Rpn11–Rpn8 heterodimerization. Upon recruitment of Rpn6, the module 1 intermediate was competent to lock into base-CP and reconstitute an incomplete 26S proteasome. Thus, base-CP can serve as a platform for gradual incorporation of lid, along a proteasome assembly pathway. Identification of proteasome intermediates and reconstitution of minimal functional units should clarify aspects of the inner workings of this machine and how multiple catalytic processes are synchronized within the 26S proteasome holoenzymes. PMID:26182356

Interconversion of Functional Motions between Mesophilic and Thermophilic Adenylate Kinases

PubMed Central

Daily, Michael D.; Phillips, George N.; Cui, Qiang

2011-01-01

Dynamic properties are functionally important in many proteins, including the enzyme adenylate kinase (AK), for which the open/closed transition limits the rate of catalytic turnover. Here, we compare our previously published coarse-grained (double-well Gō) simulation of mesophilic AK from E. coli (AKmeso) to simulations of thermophilic AK from Aquifex aeolicus (AKthermo). In AKthermo, as with AKmeso, the LID domain prefers to close before the NMP domain in the presence of ligand, but LID rigid-body flexibility in the open (O) ensemble decreases significantly. Backbone foldedness in O and/or transition state (TS) ensembles increases significantly relative to AKmeso in some interdomain backbone hinges and within LID. In contact space, the TS of AKthermo has fewer contacts at the CORE-LID interface but a stronger contact network surrounding the CORE-NMP interface than the TS of AKmeso. A “heated” simulation of AKthermo at 375K slightly increases LID rigid-body flexibility in accordance with the “corresponding states” hypothesis. Furthermore, while computational mutation of 7 prolines in AKthermo to their AKmeso counterparts produces similar small perturbations, mutation of these sites, especially positions 8 and 155, to glycine is required to achieve LID rigid-body flexibility and hinge flexibilities comparable to AKmeso. Mutating the 7 sites to proline in AKmeso reduces some hinges' flexibilities, especially hinge 2, but does not reduce LID rigid-body flexibility, suggesting that these two types of motion are decoupled in AKmeso. In conclusion, our results suggest that hinge flexibility and global functional motions alike are correlated with but not exclusively determined by the hinge residues. This mutational framework can inform the rational design of functionally important flexibility and allostery in other proteins toward engineering novel biochemical pathways. PMID:21779157

EVALUATION OF ENGINEERING CONTROLS FOR THE MIXING OF FLAVORINGS CONTAINING DIACETYL AND OTHER VOLATILE INGREDIENTS

PubMed Central

Hirst, Deborah V.L.; Dunn, Kevin H.; Shulman, Stanley A.; Hammond, Duane R.; Sestito, Nicholas

2015-01-01

Exposures to diacetyl, a primary ingredient of butter flavoring, have been shown to cause respiratory disease among workers who mix flavorings. This study focused on evaluating ventilation controls designed to reduce emissions from the flavor mixing tanks, the major source of diacetyl in the plants. Five exhaust hood configurations were evaluated in the laboratory: standard hinged lid-opened, standard hinged lid-closed, hinged lid-slotted, dome with 38-mm gap, and dome with 114-mm gap. Tracer gas tests were performed to evaluate quantitative capture efficiency for each hood. A perforated copper coil was used to simulate an area source within the 1.2-meter diameter mixing tank. Capture efficiencies were measured at four hood exhaust flow rates (2.83, 5.66, 11.3, and 17.0 cubic meters per minute) and three cross draft velocities (0, 30, and 60 meters per minute). All hoods evaluated performed well with capture efficiencies above 90% for most combinations of exhaust volume and cross drafts. The standard hinged lid was the least expensive to manufacture and had the best average capture efficiency (over 99%) in the closed configuration for all exhaust flow rates and cross drafts. The hinged lid-slotted hood had some of the lowest capture efficiencies at the low exhaust flow rates compared to the other hood designs. The standard hinged lid performed well, even in the open position, and it provided a flexible approach to controlling emissions from mixing tanks. The dome hood gave results comparable to the standard hinged lid but it is more expensive to manufacture. The results of the study indicate that emissions from mixing tanks used in the production of flavorings can be controlled using simple inexpensive exhaust hoods. PMID:24649880

Rapid Prototyping in PVS

NASA Technical Reports Server (NTRS)

Munoz, Cesar A.; Butler, Ricky (Technical Monitor)

2003-01-01

PVSio is a conservative extension to the PVS prelude library that provides basic input/output capabilities to the PVS ground evaluator. It supports rapid prototyping in PVS by enhancing the specification language with built-in constructs for string manipulation, floating point arithmetic, and input/output operations.

Curbeen during first EVA

NASA Image and Video Library

2006-12-13

ISS014-E-09523 (12 Dec. 2006) --- Astronaut Robert L. Curbeam, Jr., STS-116 mission specialist, participates in the mission's first of three planned sessions of extravehicular activity (EVA) as construction resumes on the International Space Station. A power tool, attached to Curbeam's spacesuit, floats at left.

Glove box on vehicular instrument panel

DOEpatents

Atarashi, Kazuya

1985-01-01

A glove box for the upper surface of an automobile dashboard whereby it may be positioned close to the driver. The glove box lid is pivotally supported by arms extending down either side to swing forwardly for opening. A hook is pivotally support adjacent an arm and weighted to swing into engagement with the arm to prevent opening of the lid during abrupt deceleration. A toggle spring assists in maintaining the lid in either the open or closed position.

Exploiting Hidden Layer Responses of Deep Neural Networks for Language Recognition

DTIC Science & Technology

2016-09-08

trained DNNs. We evaluated this ap- proach in NIST 2015 language recognition evaluation. The per- formances achieved by the proposed approach are very...activations, used in direct DNN-LID. Results from the LID experiments support our hypothesis. The LID experiments are performed on NIST Language Recognition...of-the-art I- vector system [3, 10, 11] in evaluation (eval) set of NIST LRE 2015. Combination of proposed technique and state-of-the-art I-vector

Normal flora of conjunctiva and lid margin, as well as its antibiotic sensitivity, in patients undergoing cataract surgery at Phramongkutklao Hospital.

PubMed

Ratnumnoi, Ravee; Keorochana, Narumon; Sontisombat, Chavalit

2017-01-01

This study aimed to evaluate the normal flora of conjunctiva and lid margin, as well as its antibiotic sensitivity. This was a prospective cross-sectional study. A prospective study was conducted on 120 patients who underwent cataract surgery at the Phramongkutklao Hospital from September 2014 to October 2014. Conjunctival and lid margin swabs were obtained from patients before they underwent cataract surgery. These swabs were used to inoculate blood agar and chocolate agar plates for culturing. After growth of the normal flora, the antibiotic sensitivity method using tobramycin, moxifloxacin, levofloxacin, and cefazolin was applied. Normal flora of conjunctiva and lid margin, along with its antibiotic sensitivity, from patients who underwent cataract surgery was assessed. A total of 120 eyes were included in this study, and bacterial isolation rates were identified. Five bacteria from the lid margin were cultured, namely, coagulase-negative staphylococcus (58.33%), Streptococcus spp. (2.5%), Corynebacterium (1.67%), Micrococcus spp. (1.67%), and Staphylococcus aureus (0.83%). Two bacteria from the conjunctiva were cultured, namely, coagulase-negative staphylococcus (30%) and Streptococcus spp. (0.83%). Results of antibiotic sensitivity test showed that all isolated bacteria are sensitive to cefazolin 100%, tobramycin 98.67%, levofloxacin 100%, and moxifloxacin 100%. Coagulase-negative staphylococci are the most common bacteria isolated from conjunctiva and lid margin.

Levodopa-induced Dyskinesia: Clinical Features, Pathophysiology, and Medical Management

PubMed Central

Pandey, Sanjay; Srivanitchapoom, Prachaya

2017-01-01

Levodopa-induced dyskinesia (LID) is commonly seen in Parkinson's disease patients treated with levodopa. This side effect is usually encountered after long duration of treatment, but occasionally, this may be seen even after few days or months of treatment. LID is broadly classified as peak-dose dyskinesia, wearing-off or off-period dyskinesia, and diphasic dyskinesia. Pathogenesis of LID is complex, and different neurotransmitters such as dopamine, glutamine, adenosine, and gamma-aminobutyric acid play important role altering the normal physiology of direct and indirect pathway of cortico-basal ganglia-thalamic loop responsible for fine motor control. Treatment of LID requires careful history taking and clinical examination to find the type of dyskinesia as different approach is required for different types. Changes in dopaminergic medication including continuous dopaminergic stimulation are very helpful in the management of peak-dose dyskinesia. Different types of surgical approaches including unilateral pallidotomy and deep brain stimulation have given very good result in patients, who cannot be managed by medications alone. The surgical management of LID is dealt with in detail in another review in this series. PMID:28904447

Levodopa-induced dyskinesias in Parkinson’s disease: emerging treatments

PubMed Central

Bargiotas, Panagiotis; Konitsiotis, Spyridon

2013-01-01

Parkinson’s disease therapy is still focused on the use of L-3,4-dihydroxyphenylalanine (levodopa or L-dopa) for the symptomatic treatment of the main clinical features of the disease, despite intensive pharmacological research in the last few decades. However, regardless of its effectiveness, the long-term use of levodopa causes, in combination with disease progression, the development of motor complications termed levodopa-induced dyskinesias (LIDs). LIDs are the result of profound modifications in the functional organization of the basal ganglia circuitry, possibly related to the chronic and pulsatile stimulation of striatal dopaminergic receptors by levodopa. Hence, for decades the key feature of a potentially effective agent against LIDs has been its ability to ensure more continuous dopaminergic stimulation in the brain. The growing knowledge regarding the pathophysiology of LIDs and the increasing evidence on involvement of nondopaminergic systems raises the possibility of more promising therapeutic approaches in the future. In the current review, we focus on novel therapies for LIDs in Parkinson’s disease, based mainly on agents that interfere with glutamatergic, serotonergic, adenosine, adrenergic, and cholinergic neurotransmission that are currently in testing or clinical development. PMID:24174877

Functions & Requirements for Debris Removal System Project A-2

DOE Office of Scientific and Technical Information (OSTI.GOV)

PRECECHTEL, D.R.

1999-12-29

This revision of the Functions and Requirements Document updates the approved Functions and Requirements for Debris Removal Subproject WHC-SD-SNF-FRD-009, Rev. 0. It has been revised in its entirety to reflect the current scope of work for Debris Removal as canisters and lids under the K Basin Projects work breakdown structure (WBS). In this revision the canisters and lids will be consider debris and a new set of Functions and Requirements have been developed to remove the canisters and lids from the basin.

78 FR 30297 - Alabama Power Company; Notice of Application Accepted for Filing and Soliciting Comments, Motions...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-22

... protests: June 14, 2013. All documents may be filed electronically via the Internet. See, 18 CFR 385.2001(a... existing boat dock into a floating pavilion; (4) install a boat ramp; (5) construct a parking area and...

Ciprofloxacin-lidocaine-based hydrogel: development, characterization, and in vivo evaluation in a second-degree burn model.

PubMed

Sanchez, María Florencia; Breda, Susana Andrea; Soria, Elio Andrés; Tártara, Luis Ignacio; Manzo, Rubén Hilario; Olivera, María Eugenia

2018-04-13

The purpose of this work was to develop an effective carbomer hydrogel to be used to treat second-degree burns that combined ciprofloxacin and lidocaine (CbCipLid hydrogel). Its antibiotic and anesthetic efficacy and the physical and chemical properties of the CbCipLid hydrogel (release rate and kinetics, rheology, appearance, and drug content) were evaluated both before and after a sterilization cycle and also after 6 months of storage. For the in vivo studies, second-degree burns were developed in a rat model. Animals were divided into three groups: CbCipLid hydrogel, silver sulfadiazine cream (reference), and carbomer hydrogel (as control). The treatments were applied daily for 21 days, and the healing was monitored by macroscopic observation and histologic evaluation. The anesthetic effect was evaluated through the corneal touch threshold in a rabbit eye model. The CbCipLid hydrogel obtained is transparent and allows the loading of ciprofloxacin above its solubility at a neutral pH, with a rheology which is convenient for topical administration. Its physical and chemical properties remained unchanged after sterilization and for at least six additional months. Both ciprofloxacin and lidocaine are reversibly released from the CbCipLid hydrogel with a kinetics fitting the Higuchi model. The presence of a biologic-like fluid increased the rate of drug delivery through an ionic exchange mechanism. Treatment with the CbCipLid hydrogel decreased the wound-healing period, compared with the reference, and was associated with a greater number of fibroblasts and a faster rate of epithelialization and dermis reconstruction. These differences were assigned to the moist environment provided by the hydrogel and also to the presence of a therapeutic concentration of ciprofloxacin. Moreover, CbCipLid hydrogel provides an immediate anesthetic effect, which is significantly more intense than that of the reference. Based on these results, it is believed that the CbCipLid hydrogel could be a potential candidate in the prophylaxis/treatment of second-degree burns.

Evaluating the effectiveness of management practices on hydrology and water quality at watershed scale with a rainfall-runoff model.

PubMed

Liu, Yaoze; Bralts, Vincent F; Engel, Bernard A

2015-04-01

The adverse influence of urban development on hydrology and water quality can be reduced by applying best management practices (BMPs) and low impact development (LID) practices. This study applied green roof, rain barrel/cistern, bioretention system, porous pavement, permeable patio, grass strip, grassed swale, wetland channel, retention pond, detention basin, and wetland basin, on Crooked Creek watershed. The model was calibrated and validated for annual runoff volume. A framework for simulating BMPs and LID practices at watershed scales was created, and the impacts of BMPs and LID practices on water quantity and water quality were evaluated with the Long-Term Hydrologic Impact Assessment-Low Impact Development 2.1 (L-THIA-LID 2.1) model for 16 scenarios. The various levels and combinations of BMPs/LID practices reduced runoff volume by 0 to 26.47%, Total Nitrogen (TN) by 0.30 to 34.20%, Total Phosphorus (TP) by 0.27 to 47.41%, Total Suspended Solids (TSS) by 0.33 to 53.59%, Lead (Pb) by 0.30 to 60.98%, Biochemical Oxygen Demand (BOD) by 0 to 26.70%, and Chemical Oxygen Demand (COD) by 0 to 27.52%. The implementation of grass strips in 25% of the watershed where this practice could be applied was the most cost-efficient scenario, with cost per unit reduction of $1m3/yr for runoff, while cost for reductions of two pollutants of concern was $445 kg/yr for Total Nitrogen (TN) and $4871 kg/yr for Total Phosphorous (TP). The scenario with very high levels of BMP and LID practice adoption (scenario 15) reduced runoff volume and pollutant loads from 26.47% to 60.98%, and provided the greatest reduction in runoff volume and pollutant loads among all scenarios. However, this scenario was not as cost-efficient as most other scenarios. The L-THIA-LID 2.1 model is a valid tool that can be applied to various locations to help identify cost effective BMP/LID practice plans at watershed scales. Copyright © 2014 Elsevier B.V. All rights reserved.

A Cross-Sectional Survey of the Association between Bilateral Topical Prostaglandin Analogue Use and Ocular Adnexal Features

PubMed Central

Shah, Mamta; Lee, Grace; Lefebvre, Daniel R.; Kronberg, Benjamin; Loomis, Stephanie; Brauner, Stacey C.; Turalba, Angela; Rhee, Douglas J.; Freitag, Suzanne K.; Pasquale, Louis R.

2013-01-01

We studied the relation between prostaglandin analogue use and ocular adnexal features. We used a prospective, cross-sectional study involving 157 current, 15 past, and 171 never users of prostaglandin analogues. Patients 50 years of age or older and without conditions affecting ocular adnexal anatomy underwent glaucoma medication use history, external digital photography and systematic external adnexal exam. Two masked readers assessed the digital photos for upper lid dermatochalasis and lower lid steatoblepharon using a validated grading scheme. Another masked clinical examiner also assessed upper lid ptosis, levator muscle function, and inferior scleral show. We performed ordinal logistic regression analysis accounting for multiple covariates to assess the relation between prostaglandin analogue use and adnexal features. Multivariable analyses indicated there was a 230-fold increased risk of incremental involution of dermatochalasis (odds ratio (OR)  =  2.30; 95% confidence interval (CI) 1.43–3.69; p = 5.44E-04) and a 249-fold increased risk of incremental loss of lower lid steatoblepharon (OR  =  2.49; 95% CI, 1.54–4.03; p =  1.98E-04) associated with current prostaglandin analogue use (bimatoprost 0.03%, travoprost 0.005%, or latanoprost 0.004%) versus prostaglandin analogue never or past users. Upper lid ptosis (OR  =  4.04; 95% CI, 2.43–6.72; p = 7.37E-08), levator dysfunction (OR =  7.51; 95% CI, 3.39–16.65; p = 6.74E-07) and lower lid retraction (OR = 2.60; 95% CI, 1.58–4.28; p = 1.72E-04) were highly associated with current prostaglandin analogue use versus prostaglandin analogue never or past users. The associations between prostaglandin analogue use and deepening of the upper lid sulci and between prostaglandin analogue use and loss of inferior periorbital fat are confirmed in this multivariable analysis. The associations between prostaglandin analogue use and levator muscle dysfunction and between prostaglandin analogue use and upper lid ptosis represent significant side effects that could impact visual function in glaucoma patients. PMID:23650502

Cesar Chavez Street Headwaters Pilot LID Project

EPA Pesticide Factsheets

Information about the SFBWQP Cesar Chavez Street LID Pilot Project, part of an EPA competitive grant program to improve SF Bay water quality focused on restoring impaired waters and enhancing aquatic resources.

Regional approach to modeling the transport of floating plastic debris in the Adriatic Sea.

PubMed

Liubartseva, S; Coppini, G; Lecci, R; Creti, S

2016-02-15

Sea surface concentrations of plastics and their fluxes onto coastlines are simulated over 2009-2015. Calculations incorporate combinations of terrestrial and maritime litter inputs, the Lagrangian model MEDSLIK-II forced by AFS ocean current simulations, and ECMWF wind analyses. With a relatively short particle half-life of 43.7 days, the Adriatic Sea is defined as a highly dissipative basin where the shoreline is, by construction, the main sink of floating debris. Our model results show that the coastline of the Po Delta receives a plastic flux of approximately 70 kg(km day)(-1). The most polluted sea surface area (>10 g km(-2) floating debris) is represented by an elongated band shifted to the Italian coastline and narrowed from northwest to southeast. Evident seasonality is found in the calculated plastic concentration fields and the coastline fluxes. Complex source-receptor relationships among the basin's subregions are quantified in impact matrices. Copyright © 2015 Elsevier Ltd. All rights reserved.

Congenital orbital teratoma.

PubMed

Aiyub, Shereen; Chan, Wengonn; Szetu, John; Sullivan, Laurence J; Pater, John; Cooper, Peter; Selva, Dinesh

2013-12-01

We present a case of mature congenital orbital teratoma managed with lid-sparing exenteration and dermis fat graft. This is a case report on the management of congenital orbital teratoma. A full-term baby was born in Fiji with prolapsed right globe which was surrounded by a nonpulsatile, cystic mass. Clinical and imaging features were consistent with congenital orbital teratoma. Due to limited surgical expertise, the patient was transferred to Adelaide, Australia for further management. The patient underwent a lid-sparing exenteration with frozen section control of the apical margin. A dermis fat graft from the groin was placed beneath the lid skin to provide volume. Histopathology revealed mature tissues from each of the three germ cell layers which confirmed the diagnosis of mature teratoma. We describe the successful use of demis fat graft in socket reconstruction following lid-sparing exenteration for congenital orbital teratoma.

Congenital orbital teratoma

PubMed Central

Aiyub, Shereen; Chan, Weng Onn; Szetu, John; Sullivan, Laurence J; Pater, John; Cooper, Peter; Selva, Dinesh

2013-01-01

We present a case of mature congenital orbital teratoma managed with lid-sparing exenteration and dermis fat graft. This is a case report on the management of congenital orbital teratoma. A full-term baby was born in Fiji with prolapsed right globe which was surrounded by a nonpulsatile, cystic mass. Clinical and imaging features were consistent with congenital orbital teratoma. Due to limited surgical expertise, the patient was transferred to Adelaide, Australia for further management. The patient underwent a lid-sparing exenteration with frozen section control of the apical margin. A dermis fat graft from the groin was placed beneath the lid skin to provide volume. Histopathology revealed mature tissues from each of the three germ cell layers which confirmed the diagnosis of mature teratoma. We describe the successful use of demis fat graft in socket reconstruction following lid-sparing exenteration for congenital orbital teratoma. PMID:23619505

NASA Docking System (NDS) Interface Definitions Document (IDD). Revision F, Dec. 15, 2011

NASA Technical Reports Server (NTRS)

Lewis, James

2011-01-01

The NASA Docking System (NDS) mating system supports low approach velocity docking and provides a modular and reconfigurable standard interface, supporting crewed and autonomous vehicles during mating and assembly operations. The NDS is NASA s implementation for the International Docking System Standard (IDSS) using low impact docking technology. All NDS configurations can mate with the configuration specified in the IDSS Interface Definition Document (IDD), Revision A, released May 13, 2011. The NDS evolved from the Low Impact Docking System (LIDS). The term (and its associated acronym), international Low Impact Docking System (iLIDS) is also used to describe this system. NDS and iLIDS may be used interchangeability. Some of the heritage documentation and implementations (e.g., software command names) used on the NDS will continue to use the LIDS acronym.

Dynamic coupling between the LID and NMP domain motions in the catalytic conversion of ATP and AMP to ADP by adenylate kinase

NASA Astrophysics Data System (ADS)

Jana, Biman; Adkar, Bharat V.; Biswas, Rajib; Bagchi, Biman

2011-01-01

The catalytic conversion of adenosine triphosphate (ATP) and adenosine monophosphate (AMP) to adenosine diphosphate (ADP) by adenylate kinase (ADK) involves large amplitude, ligand induced domain motions, involving the opening and the closing of ATP binding domain (LID) and AMP binding domain (NMP) domains, during the repeated catalytic cycle. We discover and analyze an interesting dynamical coupling between the motion of the two domains during the opening, using large scale atomistic molecular dynamics trajectory analysis, covariance analysis, and multidimensional free energy calculations with explicit water. Initially, the LID domain must open by a certain amount before the NMP domain can begin to open. Dynamical correlation map shows interesting cross-peak between LID and NMP domain which suggests the presence of correlated motion between them. This is also reflected in our calculated two-dimensional free energy surface contour diagram which has an interesting elliptic shape, revealing a strong correlation between the opening of the LID domain and that of the NMP domain. Our free energy surface of the LID domain motion is rugged due to interaction with water and the signature of ruggedness is evident in the observed root mean square deviation variation and its fluctuation time correlation functions. We develop a correlated dynamical disorder-type theoretical model to explain the observed dynamic coupling between the motion of the two domains in ADK. Our model correctly reproduces several features of the cross-correlation observed in simulations.

Urban base flow with low impact development

USGS Publications Warehouse

Bhaskar, Aditi; Hogan, Dianna M.; Archfield, Stacey A.

2016-01-01

A novel form of urbanization, low impact development (LID), aims to engineer systems that replicate natural hydrologic functioning, in part by infiltrating stormwater close to the impervious surfaces that generate it. We sought to statistically evaluate changes in a base flow regime because of urbanization with LID, specifically changes in base flow magnitude, seasonality, and rate of change. We used a case study watershed in Clarksburg, Maryland, in which streamflow was monitored during whole-watershed urbanization from forest and agricultural to suburban residential development using LID. The 1.11-km2 watershed contains 73 infiltration-focused stormwater facilities, including bioretention facilities, dry wells, and dry swales. We examined annual and monthly flow during and after urbanization (2004–2014) and compared alterations to nearby forested and urban control watersheds. We show that total streamflow and base flow increased in the LID watershed during urbanization as compared with control watersheds. The LID watershed had more gradual storm recessions after urbanization and attenuated seasonality in base flow. These flow regime changes may be because of a reduction in evapotranspiration because of the overall decrease in vegetative cover with urbanization and the increase in point sources of recharge. Precipitation that may once have infiltrated soil, been stored in soil moisture to be eventually transpired in a forested landscape, may now be recharged and become base flow. The transfer of evapotranspiration to base flow is an unintended consequence to the water balance of LID.

Movement patterns of peak-dose levodopa-induced dyskinesias in patients with Parkinson's disease.

PubMed

Gour, Jackie; Edwards, Roderick; Lemieux, Sarah; Ghassemi, Mehrdad; Jog, Mandar; Duval, Christian

2007-09-14

The present study characterized involuntary movements associated with levodopa-induced dyskinesias (LID) in patients with Parkinson's disease. We used amplitude, proportional energy, frequency dispersion and sample entropy to determine whether LID movement patterns are truly random, as clinical description seems to suggest, or possess some underlying pattern that is not visible to the naked eye. LID was captured using a magnetic tracker system, which provided 3D rendering of whole-body LID. Patients were instructed to maintain a standing position, with arms extended in front of them. We compared the measurements of the dyskinetic PD group (DPD) with 10 patients without dyskinesias (NDPD) and 10 control subjects. In comparison to the other two groups, movement patterns from the DPD group had significantly higher amplitude, confirming the presence of dyskinesias. In addition, higher frequency components in the power spectrum of velocity were detected, suggestive of higher velocity in LID movement. Furthermore, there was a concentration in narrow frequency bands, which suggested stable oscillatory activity. Finally, sample entropy revealed more regularity in the DPD group. Although not statistically significant, we found that the amplitude from the NDPD group had a tendency to be smaller than those of controls. As well, the spectra were often more dispersed for the NDPD group. In conclusion, the present results suggest that LID cannot be considered as purely random movement since they possess some deterministic pattern of motion. This may provide a way for patients to adapt to these involuntary movements while performing voluntary motor acts.

14 CFR 25.755 - Hulls.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Hulls. 25.755 Section 25.755 Aeronautics... STANDARDS: TRANSPORT CATEGORY AIRPLANES Design and Construction Floats and Hulls § 25.755 Hulls. (a) Each hull must have enough watertight compartments so that, with any two adjacent compartments flooded, the...

Probing Conformational Changes and Interfacial Recognition Site of Lipases With Surfactants and Inhibitors.

PubMed

Mateos-Diaz, E; Amara, S; Roussel, A; Longhi, S; Cambillau, C; Carrière, F

2017-01-01

Structural studies on lipases by X-ray crystallography have revealed conformational changes occurring in the presence of surfactants/inhibitors and the pivotal role played by a molecular "lid" of variable size and structure depending on the enzyme. Besides controlling the access to the enzyme active site, the lid is involved in lipase activation, formation of the interfacial recognition site (IRS), and substrate docking within the active site. The combined use of surfactants and inhibitors has been critical for a better understanding of lipase structure-function relationships. An overview of crystal structures of lipases in complex with surfactants and inhibitors reveals common structural features and shows how surfactants monomers interact with the lid in its open conformation. The location of surfactants, inhibitors, and hydrophobic residues exposed upon lid opening provides insights into the IRS of lipases. The mechanism by which surfactants promote the lid opening can be further investigated in solution by site-directed spin labeling of lipase coupled to electron paramagnetic resonance spectroscopy. These experimental approaches are illustrated here by results obtained with mammalian digestive lipases, fungal lipases, and cutinases. © 2017 Elsevier Inc. All rights reserved.

Multiobjective optimization of low impact development stormwater controls

NASA Astrophysics Data System (ADS)

Eckart, Kyle; McPhee, Zach; Bolisetti, Tirupati

2018-07-01

Green infrastructure such as Low Impact Development (LID) controls are being employed to manage the urban stormwater and restore the predevelopment hydrological conditions besides improving the stormwater runoff water quality. Since runoff generation and infiltration processes are nonlinear, there is a need for identifying optimal combination of LID controls. A coupled optimization-simulation model was developed by linking the U.S. EPA Stormwater Management Model (SWMM) to the Borg Multiobjective Evolutionary Algorithm (Borg MOEA). The coupled model is capable of performing multiobjective optimization which uses SWMM simulations as a tool to evaluate potential solutions to the optimization problem. The optimization-simulation tool was used to evaluate low impact development (LID) stormwater controls. A SWMM model was developed, calibrated, and validated for a sewershed in Windsor, Ontario and LID stormwater controls were tested for three different return periods. LID implementation strategies were optimized using the optimization-simulation model for five different implementation scenarios for each of the three storm events with the objectives of minimizing peak flow in the stormsewers, reducing total runoff, and minimizing cost. For the sewershed in Windsor, Ontario, the peak run off and total volume of the runoff were found to reduce by 13% and 29%, respectively.

Frisbees, Can Lids, and Gyroscopic Effects.

ERIC Educational Resources Information Center

Crane, H. Richard

1983-01-01

Provides an explanation for the observed motion of frisbees, can lids, "clay pidgeons," and flat stones when these objects are thrown through the air. Explanation focuses on forces (gravity and air), torque, and gyroscopic precession. (JN)

Preventing light-induced degradation in multicrystalline silicon

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lindroos, J., E-mail: jeanette.lindroos@aalto.fi; Boulfrad, Y.; Yli-Koski, M.

2014-04-21

Multicrystalline silicon (mc-Si) is currently dominating the silicon solar cell market due to low ingot costs, but its efficiency is limited by transition metals, extended defects, and light-induced degradation (LID). LID is traditionally associated with a boron-oxygen complex, but the origin of the degradation in the top of the commercial mc-Si brick is revealed to be interstitial copper. We demonstrate that both a large negative corona charge and an aluminum oxide thin film with a built-in negative charge decrease the interstitial copper concentration in the bulk, preventing LID in mc-Si.

Clamshell closure for metal drum

DOEpatents

Blanton, Paul S

2014-09-30

Closure ring to retain a lid in contact with a metal drum in central C-section conforming to the contact area between a lid and the rim of a drum and further having a radially inwardly directed flange and a vertically downwardly directed flange attached to the opposite ends of the C-section. The additional flanges reinforce the top of the drum by reducing deformation when the drum is dropped and maintain the lid in contact with the drum. The invention is particularly valuable in transportation and storage of fissile material.

Preventing light-induced degradation in multicrystalline silicon

NASA Astrophysics Data System (ADS)

Lindroos, J.; Boulfrad, Y.; Yli-Koski, M.; Savin, H.

2014-04-01

Multicrystalline silicon (mc-Si) is currently dominating the silicon solar cell market due to low ingot costs, but its efficiency is limited by transition metals, extended defects, and light-induced degradation (LID). LID is traditionally associated with a boron-oxygen complex, but the origin of the degradation in the top of the commercial mc-Si brick is revealed to be interstitial copper. We demonstrate that both a large negative corona charge and an aluminum oxide thin film with a built-in negative charge decrease the interstitial copper concentration in the bulk, preventing LID in mc-Si.

Ocular surface and tear film status among contact lens wearers and non-wearers who use VDT at work: comparing three different lens types.

PubMed

Tauste, Ana; Ronda, Elena; Baste, Valborg; Bråtveit, Magne; Moen, Bente E; Seguí Crespo, María-Del-Mar

2018-04-01

To analyze differences in the ocular surface appearance and tear film status of contact lens wearers and non-wearers in a group of visual display terminals (VDT) workers and additionally to assess differences between lens materials. Cross-sectional study of 236 office workers, of whom 92 were contact lens wearers. Workers provided information on their contact lenses (conventional hydrogel, silicone hydrogel or rigid gas permeable lenses) and exposure to VDT at work. Ocular surface and tear film status were determined by the presence of bulbar, limbal and lid redness, lid roughness and corneal staining type, and by Schirmer's and tear break-up time tests (TBUT). A generalized linear model was used to calculate the crude (cRR) and age- and sex-adjusted (aRR) relative risk to measure the association between ocular surface and tear film abnormalities and contact lens use and type. The aRR of ocular surface abnormalities was higher in contact lens wearers compared to non-wearers: bulbar redness (aRR 1.69; 95% CI 1.25-2.30), limbal redness (aRR 2.87; 1.88-4.37), lid redness (aRR 2.53; 1.35-4.73) and lid roughness (aRR 7.03; 1.31-37.82). VDT exposure > 4 h/day increased wearers' risk of limbal and lid redness. Conventional hydrogel wearers had the highest risk of ocular surface abnormalities, followed by silicone hydrogel wearers. Both contact and non-contact lens wearers had a high prevalence of altered TBUT (77.3 and 75.7% respectively) and Schirmer (51.8 and 41.3%). Regular contact lens use during VDT exposure at work increases risk of bulbar, limbal and lid redness, and lid roughness, especially in soft contact lens wearers. The high prevalence of altered TBUT and Schirmer's results in all participants suggests that VDT use greatly affects tear film characteristics.

Influence of land development on stormwater runoff from a mixed land use and land cover catchment.

PubMed

Paule-Mercado, M A; Lee, B Y; Memon, S A; Umer, S R; Salim, I; Lee, C-H

2017-12-01

Mitigating for the negative impacts of stormwater runoff is becoming a concern due to increased land development. Understanding how land development influences stormwater runoff is essential for sustainably managing water resources. In recent years, aggregate low impact development-best management practices (LID-BMPs) have been implemented to reduce the negative impacts of stormwater runoff on receiving water bodies. This study used an integrated approach to determine the influence of land development and assess the ecological benefits of four aggregate LID-BMPs in stormwater runoff from a mixed land use and land cover (LULC) catchment with ongoing land development. It used data from 2011 to 2015 that monitored 41 storm events and monthly LULC, and a Personalized Computer Storm Water Management Model (PCSWMM). The four aggregate LID-BMPs are: ecological (S1), utilizing pervious covers (S2), and multi-control (S3) and (S4). These LID-BMPs were designed and distributed in the study area based on catchment characteristics, cost, and effectiveness. PCSWMM was used to simulate the monitored storm events from 2014 (calibration: R 2 and NSE>0.5; RMSE <11) and 2015 (validation: R 2 and NSE>0.5; RMSE <12). For continuous simulation and analyzing LID-BMPs scenarios, the five-year (2011 to 2015) stormwater runoff data and LULC change patterns (only 2015 for LID-BMPs) were used. Results show that the expansion of bare land and impervious cover, soil alteration, and high amount of precipitation influenced the stormwater runoff variability during different phases of land development. The four aggregate LID-BMPs reduced runoff volume (34%-61%), peak flow (6%-19%), and pollutant concentrations (53%-83%). The results of this study, in addition to supporting local LULC planning and land development activities, also could be applied to input data for empirical modeling, and designing sustainable stormwater management guidelines and monitoring strategies. Copyright © 2017 Elsevier B.V. All rights reserved.

Wireless power-receiving assembly for a telemetry system in a high-temperature environment of a combustion turbine engine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bevly, III, Alex J.; McConkey, Joshua S.

In a telemetry system (100) in a high-temperature environment of a combustion turbine engine (10), a wireless power-receiving coil assembly (116) may be affixed to a movable component (104) of the turbine engine. Power-receiving coil assembly (116) may include a radio-frequency transparent housing (130) having an opening (132). A lid (134) may be provided to close the opening of the housing. Lid (134) may be positioned to provide support against a surface (120) of the movable component. An induction coil (133) is disposed in the housing distally away from the lid and encased between a first layer (136) and amore » last layer (140) of a potting adhesive. Lid (134) is arranged to provide vibrational buffering between the surface (120) of the movable component (104) and the layers encasing the induction coil.« less

Low entomological impact of new water supply infrastructure in southern Vietnam, with reference to dengue vectors.

PubMed

Tran, Hau P; Huynh, Trang T T; Nguyen, Yen T; Kutcher, Simon; O'Rourke, Peter; Marquart, Louise; Ryan, Peter A; Kay, Brian H

2012-10-01

We did a prospective study in southern Vietnam where new water infrastructure was added. New 1,200-L tanks may present potential breeding grounds for Aedes aegypti, particularly when sealed lids were not always supplied. Some householders in these communes received a piped water supply, however there was no reduction in water storage practices. The prevalence of Aedes aegypti immatures in tank and tap households reached 73%, but were non-significantly different from each other and from control households that received no infrastructure. In all three communes, standard jars comprised from 48% to 71% of containers but were associated with > 90% of III-IV instars and pupae on occasions. In contrast, project tanks contributed from 0-21% of the total population. Non-functional or no lids were apparent 4 months after installation in 45-76% of new tanks, but there was no difference between communes with lids and without lids.

46 CFR 160.057-7 - Procedure for approval.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 6 2014-10-01 2014-10-01 false Procedure for approval. 160.057-7 Section 160.057-7 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Floating Orange Smoke Distress Signals (15 Minutes) § 160.057-7...

46 CFR 160.057-7 - Procedure for approval.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 6 2010-10-01 2010-10-01 false Procedure for approval. 160.057-7 Section 160.057-7 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Floating Orange Smoke Distress Signals (15 Minutes) § 160.057-7...

46 CFR 160.022-7 - Procedure for approval.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 6 2012-10-01 2012-10-01 false Procedure for approval. 160.022-7 Section 160.022-7 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Floating Orange Smoke Distress Signals (5 Minutes) § 160.022-7...

46 CFR 160.022-7 - Procedure for approval.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 6 2011-10-01 2011-10-01 false Procedure for approval. 160.022-7 Section 160.022-7 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Floating Orange Smoke Distress Signals (5 Minutes) § 160.022-7...

46 CFR 160.022-7 - Procedure for approval.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 6 2014-10-01 2014-10-01 false Procedure for approval. 160.022-7 Section 160.022-7 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Floating Orange Smoke Distress Signals (5 Minutes) § 160.022-7...

46 CFR 160.057-7 - Procedure for approval.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 6 2013-10-01 2013-10-01 false Procedure for approval. 160.057-7 Section 160.057-7 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Floating Orange Smoke Distress Signals (15 Minutes) § 160.057-7...

46 CFR 160.022-7 - Procedure for approval.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 6 2013-10-01 2013-10-01 false Procedure for approval. 160.022-7 Section 160.022-7 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Floating Orange Smoke Distress Signals (5 Minutes) § 160.022-7...

46 CFR 160.057-7 - Procedure for approval.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 6 2012-10-01 2012-10-01 false Procedure for approval. 160.057-7 Section 160.057-7 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Floating Orange Smoke Distress Signals (15 Minutes) § 160.057-7...

46 CFR 160.057-7 - Procedure for approval.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 6 2011-10-01 2011-10-01 false Procedure for approval. 160.057-7 Section 160.057-7 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Floating Orange Smoke Distress Signals (15 Minutes) § 160.057-7...

46 CFR 160.022-7 - Procedure for approval.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 6 2010-10-01 2010-10-01 false Procedure for approval. 160.022-7 Section 160.022-7 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Floating Orange Smoke Distress Signals (5 Minutes) § 160.022-7...

46 CFR 63.20-1 - Specific control system requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... interlock must ensure low fire start when variable firing rates are used. (c) Water level controls and low water cutoff controls. Water level controls must be constructed and located to minimize the effects of vessel roll and pitch. Float chamber low water cutoff controls using stuffing boxes to transmit the...

46 CFR 63.20-1 - Specific control system requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... interlock must ensure low fire start when variable firing rates are used. (c) Water level controls and low water cutoff controls. Water level controls must be constructed and located to minimize the effects of vessel roll and pitch. Float chamber low water cutoff controls using stuffing boxes to transmit the...

46 CFR 63.20-1 - Specific control system requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... interlock must ensure low fire start when variable firing rates are used. (c) Water level controls and low water cutoff controls. Water level controls must be constructed and located to minimize the effects of vessel roll and pitch. Float chamber low water cutoff controls using stuffing boxes to transmit the...

Modeling Plant Uptake of Metal in Constructed Wetlands Supported by Experimentally Derived Uptake Rates.

DTIC Science & Technology

1996-12-01

nuttallii Waterweed Vallisneria spp. Wild Celery; Tape Grass Freshwater Marsh - Floating Eichhornia crassipes Water Hyacinth Lemna spp. Duckweed...for life, many others can cause toxic effects from seemingly minor exposure. All of these metals are 21 toxic to aquatic life at low concentrations

Mechanism for rapid passive-dynamic prey capture in a pitcher plant.

PubMed

Bauer, Ulrike; Paulin, Marion; Robert, Daniel; Sutton, Gregory P

2015-10-27

Plants use rapid movements to disperse seed, spores, or pollen and catch animal prey. Most rapid-release mechanisms only work once and, if repeatable, regaining the prerelease state is a slow and costly process. We present an encompassing mechanism for a rapid, repeatable, passive-dynamic motion used by a carnivorous pitcher plant to catch prey. Nepenthes gracilis uses the impact of rain drops to catapult insects from the underside of the canopy-like pitcher lid into the fluid-filled trap below. High-speed video and laser vibrometry revealed that the lid acts as a torsional spring system, driven by rain drops. During the initial downstroke, the tip of the lid reached peak velocities similar to fast animal motions and an order of magnitude faster than the snap traps of Venus flytraps and catapulting tentacles of the sundew Drosera glanduligera. In contrast to these active movements, the N. gracilis lid oscillation requires neither mechanical preloading nor metabolic energy, and its repeatability is only limited by the intensity and duration of rainfall. The underside of the lid is coated with friction-reducing wax crystals, making insects more vulnerable to perturbations. We show that the trapping success of N. gracilis relies on the combination of material stiffness adapted for momentum transfer and the antiadhesive properties of the wax crystal surface. The impact-driven oscillation of the N. gracilis lid represents a new kind of rapid plant movement with adaptive function. Our findings establish the existence of a continuum between active and passive trapping mechanisms in carnivorous plants.

Mechanism for rapid passive-dynamic prey capture in a pitcher plant

PubMed Central

Bauer, Ulrike; Paulin, Marion; Robert, Daniel; Sutton, Gregory P.

2015-01-01

Plants use rapid movements to disperse seed, spores, or pollen and catch animal prey. Most rapid-release mechanisms only work once and, if repeatable, regaining the prerelease state is a slow and costly process. We present an encompassing mechanism for a rapid, repeatable, passive-dynamic motion used by a carnivorous pitcher plant to catch prey. Nepenthes gracilis uses the impact of rain drops to catapult insects from the underside of the canopy-like pitcher lid into the fluid-filled trap below. High-speed video and laser vibrometry revealed that the lid acts as a torsional spring system, driven by rain drops. During the initial downstroke, the tip of the lid reached peak velocities similar to fast animal motions and an order of magnitude faster than the snap traps of Venus flytraps and catapulting tentacles of the sundew Drosera glanduligera. In contrast to these active movements, the N. gracilis lid oscillation requires neither mechanical preloading nor metabolic energy, and its repeatability is only limited by the intensity and duration of rainfall. The underside of the lid is coated with friction-reducing wax crystals, making insects more vulnerable to perturbations. We show that the trapping success of N. gracilis relies on the combination of material stiffness adapted for momentum transfer and the antiadhesive properties of the wax crystal surface. The impact-driven oscillation of the N. gracilis lid represents a new kind of rapid plant movement with adaptive function. Our findings establish the existence of a continuum between active and passive trapping mechanisms in carnivorous plants. PMID:26438874

Gypenosides attenuate the development of L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned rat model of Parkinson's disease.

PubMed

Shin, Keon Sung; Zhao, Ting Ting; Park, Keun Hong; Park, Hyun Jin; Hwang, Bang Yeon; Lee, Chong Kil; Lee, Myung Koo

2015-04-21

Gypenosides (GPS) and ethanol extract of Gynostemma pentaphyllum (GP-EX) show anxiolytic effects on affective disorders in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of Parkinson's disease (PD). Long-term administration of L-3,4-dihydroxyphenylalanine (L-DOPA) leads to the development of severe motor side effects such as L-DOPA-induced-dyskinesia (LID) in PD. The present study investigated the effects of GPS and GP-EX on LID in a 6-hydroxydopamine (6-OHDA)-lesioned rat model of PD. Daily administration of L-DOPA (25 mg/kg) in the 6-OHDA-lesioned rat model of PD for 22 days induced expression of LID, which was determined by the body and locomotive AIMs scores and contralateral rotational behaviors. However, co-treatments of GPS (25 and 50 mg/kg) or GP-EX (50 mg/kg) with L-DOPA significantly attenuated the development of LID without compromising the anti-parkinsonian effects of L-DOPA. In addition, the increases in ∆FosB expression and ERK1/2 phosphorylation in 6-OHDA-lesioned rats induced by L-DOPA administration were significantly reduced by co-treatment with GPS (25 and 50 mg/kg) or GP-EX (50 mg/kg). These results suggest that GPS (25 and 50 mg/kg) and GP-EX (50 mg/kg) effectively attenuate the development of LID by modulating the biomarker activities of ∆FosB expression and ERK1/2 phosphorylation in the 6-OHDA-lesioned rat model of PD. GPS and GP-EX will be useful adjuvant therapeutics for LID in PD.

A Cutinase from Trichoderma reesei with a lid-covered active site and kinetic properties of true lipases.

PubMed

Roussel, Alain; Amara, Sawsan; Nyyssölä, Antti; Mateos-Diaz, Eduardo; Blangy, Stéphanie; Kontkanen, Hanna; Westerholm-Parvinen, Ann; Carrière, Frédéric; Cambillau, Christian

2014-11-11

Cutinases belong to the α/β-hydrolase fold family of enzymes and degrade cutin and various esters, including triglycerides, phospholipids and galactolipids. Cutinases are able to degrade aggregated and soluble substrates because, in contrast with true lipases, they do not have a lid covering their catalytic machinery. We report here the structure of a cutinase from the fungus Trichoderma reesei (Tr) in native and inhibitor-bound conformations, along with its enzymatic characterization. A rare characteristic of Tr cutinase is its optimal activity at acidic pH. Furthermore, Tr cutinase, in contrast with classical cutinases, possesses a lid covering its active site and requires the presence of detergents for activity. In addition to the presence of the lid, the core of the Tr enzyme is very similar to other cutinase cores, with a central five-stranded β-sheet covered by helices on either side. The catalytic residues form a catalytic triad involving Ser164, His229 and Asp216 that is covered by the two N-terminal helices, which form the lid. This lid opens in the presence of surfactants, such as β-octylglucoside, and uncovers the catalytic crevice, allowing a C11Y4 phosphonate inhibitor to bind to the catalytic serine. Taken together, these results reveal Tr cutinase to be a member of a new group of lipolytic enzymes resembling cutinases but with kinetic and structural features of true lipases and a heightened specificity for long-chain triglycerides. Copyright © 2014 Elsevier Ltd. All rights reserved.

On the Evolution of Terrestrial Planets: Implications of Evolutionary Paths and Evolving Lid-States

NASA Astrophysics Data System (ADS)

Weller, M. B.; Lenardic, A.

2015-12-01

Growing geodynamic and geochemical evidence suggests that plate tectonics may not have operated on the early Earth, with both the timing of its onset and the length of its activity far from certain [e.g., 1, 2, and references therein]. Accordingly, information from current observations and processes have the potential of sampling portions of the Earth that has both formed under and been modified by differing tectonic regimes. Here we use coupled 3D mantle convection and planetary tectonics simulations to explore evolutionary paths and planetary tectonic regimes. Early in the geologic lifetime of a terrestrial planet, high mantle temperatures favour stagnant-lids. As radiogenics decay, an initial stagnant-lid may yield into a high temperature mobile-lid state. The transition from an initial stagnant-lid is a function of yield strength, in addition to both internal and surface temperatures. Each lid-state has specific diagnostics and implications for internal parameters, and consequently planetary evolution. The implication within this framework is that a system with a different thermal evolution has the potential to migrate through tectonic regimes at the same 'thermal time' (e.g. temperature), but very different 'temporal times'. This indicate that multiple modes of convection and surface tectonics can potentially operate on a single planetary body at different times in its evolution, as consequence of changing internal parameters, surface temperatures, and differing thermal histories. We will discuss the implications of terrestrial worlds that can alternate, and be offset between multiple tectonic states over giga-year timescales. [1] O'Neill et. al. (2013b) Geol. Soc. London; [2] Weller et al. (2015) EPSL

On the analysis of activation energy of PS 35000 in various solvents

NASA Astrophysics Data System (ADS)

Padmanaban, R.; Venkatramanan, K.

2015-08-01

Polymer is a macromolecule, composed of many repeated subunits. Polystyrene is a polymer of styrene. Polystyrene has very low impact strength. Polystyrene generally leads to lower tensile strength, crystal grades being stiff and brittle. It is used to construct clamshell packs, cookie trays, cups, forks, spoons, cushioning materials for packaging, disposable medical devices, egg cartons, fast food containers, lids, lunch boxes, meat trays and also used in civil construction (concrete form-work or weight reduction on foundations). In the present study an attempt has been made to compute the viscosity of Polystyrene (PS 35000) in toluene and benzene in different concentrations (0.5%, 1.0%, 1.5%, 2.0% & 2.5%) at different temperatures (303 K, 308 K, 313 K & 318 K). From these experimental data the activation energy is calculated and the effect of solvent is analysed.

Improved latrine cleanliness through behaviour change and changes in quality of latrine construction: a longitudinal intervention study in rural Burundi.

PubMed

Mosler, Hans-Joachim; Sonego, Ina Lucia

2017-10-01

Latrine cleanliness increased in the intervention group compared to the control group (increase from 21 to 31 % of latrines classified as clean in intervention [N = 198] and decrease from 37 to 27 % in control [N = 91]). Improved habitual latrine cleaning lead to latrines being 3.5 times more likely to improve in observed latrine cleanliness (χ 2  = 16.36, p < .001) and so did improvements in quality of latrine construction, eg households that had installed a lid were 7.39 times more likely to have a cleaner latrine (χ 2  = 4.46, p < .05). Changes in psychosocial factors, namely forgetting, personal norm, satisfaction with cleanliness, explained much of the change in habitual latrine cleaning (adj. r 2  = .46). Behaviour change interventions targeting psychosocial factors and quality of latrine construction seem promising to ensure clean and hygienic latrines.

Functional Specification and Simulation of a Floating Point Co-Processor for SPUR

DTIC Science & Technology

1986-08-01

depend on this state will not be stable until the next phase; this leaves the problem of how to control events that must occur on phi 1 of a cycle. The... problems with the structure of the chip description. The worst of these problems is the absence of Slang constructs for coding separate chip component...constructs such as UNK as well. Another related problem was the inability to explicitly declare the size of Slang node values. \\Vhile the correct

STORMWATER MANAGEMENT AND LOW IMPACT DEVELOPMENT PRESENTATION DESCRIPTION

EPA Science Inventory

Low Impact Development (LID) is the general term typically used to characterize a comprehensive array of site planning, design and pollution prevention strategies that when combined create a more economically sustainable and ecologically functional urban landscape. LID uses a dec...

DETAIL VIEW OF BRIDGE CRANE USED TO LIFT DOMED LIDS ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

DETAIL VIEW OF BRIDGE CRANE USED TO LIFT DOMED LIDS OF THE ALTITUDE CHAMBERS, FACING SOUTHWEST - Cape Canaveral Air Force Station, Launch Complex 39, Altitude Chambers, First Street, between Avenue D and Avenue E, Cape Canaveral, Brevard County, FL

Barriers to implementing low impact development approaches in Washington State roadways and highways.

DOT National Transportation Integrated Search

2010-06-04

Low impact development (LID) is an approach to stormwater management that seeks to mimic the natural hydrologic functions of stormwater runoff prior to development. In general, LID techniques emphasize infiltration and evapotranspiration to remove po...

An SDO/AIA-Observed Filament Eruption Triggered by a Lid-Removal Onset Mechanism

NASA Astrophysics Data System (ADS)

Sterling, A. C.; Moore, R. L.; Falconer, D. A.; Knox, J. M.

2013-12-01

An eruption of a solar filament often presages the onset of a more general solar eruption, often leading to a solar flare and coronal mass ejection (CME). Among the mechanisms suggested for triggering eruptions are flux cancelation, flux emergence, tether-cutting reconnection, and breakout reconnection. Here we present an example of a filament eruption due to a different trigger mechanism, which we call ``lid removal,'' whereby a magnetic structure overlying the filament is removed by a preceding adjacent eruption, rendering MHD unstable the magnetic system containing the filament and resulting in the subsequent eruption of the filament. This filament eruption occurred on 23 Jan 2013, and was well-seen in SDO/AIA 193 Ang images. Prior to its eruption the filament was at an approximately constant height above the solar surface for ~4 hours, before smoothly lifting off. Evidence for the overlying ``lid'' field was difficult to discern in 193 Ang images, but was apparent in hotter coronal images, such as SDO/AIA 335. Removal of the lid field was due to an eruption of that field visible in the hotter-corona images. In this way, the lid-removal filament-eruption mechanism is similar to recent observations of connected or cascading eruptions originating from magnetically-linked locations.

Exploring the Predisposition of the Asian Eye to Development of Dry Eye.

PubMed

Craig, Jennifer P; Wang, Michael T M; Kim, Dabin; Lee, Jung Min

2016-07-01

To investigate the influence of eyelid shape on tear film quality, ocular surface characteristics and dry eye symptomatology by comparing Asian and Caucasian populations. Seventy-four age-matched participants were recruited in a cross-sectional study. Participants were classified into Asian single lid (ASL), Asian double lid (ADL), and Caucasian double lid (CDL) groups. Dry eye symptomatology, ocular surface characteristics, and tear film quality were evaluated in a single clinical session. Meibomian gland dropout was significantly greater in both the ASL and ADL groups than in the CDL group (all P<.05). A greater proportion of ASL and ADL participants exhibited incomplete blinking than CDL patients (all P<.05). There were no significant differences in tear film quality and dry eye symptomatology between the three groups (all P>.05). Exposed ocular surface area, lissamine green staining, and lid wiper epitheliopathy were significantly greater in the ADL group compared to the CDL group (all P<.05). The CDL group displayed significantly greater anterior blepharitis and lid telangiectasia grades compared to both ASL and ADL groups (all P<.05). A higher degree of meibomian gland dropout and incomplete blinking was observed in both Asian groups compared to the Caucasian group, potentially predisposing these groups to dry eye. Copyright © 2016 Elsevier Inc. All rights reserved.

Predicting Glycerophosphoinositol Identities in Lipidomic Datasets Using VaLID (Visualization and Phospholipid Identification)—An Online Bioinformatic Search Engine

PubMed Central

McDowell, Graeme S. V.; Taylor, Graeme P.; Fai, Stephen; Bennett, Steffany A. L.

2014-01-01

The capacity to predict and visualize all theoretically possible glycerophospholipid molecular identities present in lipidomic datasets is currently limited. To address this issue, we expanded the search-engine and compositional databases of the online Visualization and Phospholipid Identification (VaLID) bioinformatic tool to include the glycerophosphoinositol superfamily. VaLID v1.0.0 originally allowed exact and average mass libraries of 736,584 individual species from eight phospholipid classes: glycerophosphates, glyceropyrophosphates, glycerophosphocholines, glycerophosphoethanolamines, glycerophosphoglycerols, glycerophosphoglycerophosphates, glycerophosphoserines, and cytidine 5′-diphosphate 1,2-diacyl-sn-glycerols to be searched for any mass to charge value (with adjustable tolerance levels) under a variety of mass spectrometry conditions. Here, we describe an update that now includes all possible glycerophosphoinositols, glycerophosphoinositol monophosphates, glycerophosphoinositol bisphosphates, and glycerophosphoinositol trisphosphates. This update expands the total number of lipid species represented in the VaLID v2.0.0 database to 1,473,168 phospholipids. Each phospholipid can be generated in skeletal representation. A subset of species curated by the Canadian Institutes of Health Research Training Program in Neurodegenerative Lipidomics (CTPNL) team is provided as an array of high-resolution structures. VaLID is freely available and responds to all users through the CTPNL resources web site. PMID:24701584

Predicting glycerophosphoinositol identities in lipidomic datasets using VaLID (Visualization and Phospholipid Identification)--an online bioinformatic search engine.

PubMed

McDowell, Graeme S V; Blanchard, Alexandre P; Taylor, Graeme P; Figeys, Daniel; Fai, Stephen; Bennett, Steffany A L

2014-01-01

The capacity to predict and visualize all theoretically possible glycerophospholipid molecular identities present in lipidomic datasets is currently limited. To address this issue, we expanded the search-engine and compositional databases of the online Visualization and Phospholipid Identification (VaLID) bioinformatic tool to include the glycerophosphoinositol superfamily. VaLID v1.0.0 originally allowed exact and average mass libraries of 736,584 individual species from eight phospholipid classes: glycerophosphates, glyceropyrophosphates, glycerophosphocholines, glycerophosphoethanolamines, glycerophosphoglycerols, glycerophosphoglycerophosphates, glycerophosphoserines, and cytidine 5'-diphosphate 1,2-diacyl-sn-glycerols to be searched for any mass to charge value (with adjustable tolerance levels) under a variety of mass spectrometry conditions. Here, we describe an update that now includes all possible glycerophosphoinositols, glycerophosphoinositol monophosphates, glycerophosphoinositol bisphosphates, and glycerophosphoinositol trisphosphates. This update expands the total number of lipid species represented in the VaLID v2.0.0 database to 1,473,168 phospholipids. Each phospholipid can be generated in skeletal representation. A subset of species curated by the Canadian Institutes of Health Research Training Program in Neurodegenerative Lipidomics (CTPNL) team is provided as an array of high-resolution structures. VaLID is freely available and responds to all users through the CTPNL resources web site.

The serotonergic system in Parkinson's patients with dyskinesia: evidence from imaging studies.

PubMed

Pagano, Gennaro; Niccolini, Flavia; Politis, Marios

2017-12-20

The purpose of review is to review the current status of positron emission tomography (PET) molecular imaging of serotonergic system in Parkinson's patients who experience levodopa-induced (LIDs) and graft-induced dyskinesias (GIDs). PET imaging studies have shown that Parkinson's disease is characterized by progressive loss of dopaminergic and serotonergic neurons. Parkinson's patients who experienced LIDs and GIDs have an aberrant spreading of serotonergic terminals, which lead to an increased serotonergic/dopaminergic terminals ratio within the putamen. Serotonergic terminals convert exogenous levodopa into dopamine in a non-physiological manner and release an abnormal amount of dopamine without an auto-regulatory feedback. This results in higher swings in synaptic levels of dopamine, which leads to the development of LIDs and GIDs. The modulation of serotonergic terminals with 5-HT 1A and 5-HT 1B receptors agonists partially reduced these motor complications. In vivo PET studies confirmed that abnormal spreading of serotonergic terminals within the putamen has a pivotal role in the development of LIDs and GIDs. However, glutamatergic, adenosinergic, opioid systems, and phosphodiesterases 10A may also play a role in the development of these motor complications. An integrative multimodal imaging approach combining PET and MRI imaging techniques is needed to fully understand the mechanisms underlying the development of LIDs and GIDs.

National Stormwater Calculator: Low Impact Development ...

EPA Pesticide Factsheets

Stormwater discharges continue to cause impairment of our Nation’s waterbodies. EPA has developed the National Stormwater Calculator (SWC) to help support local, state, and national stormwater management objectives to reduce runoff through infiltration and retention using green infrastructure practices as low impact development (LID) controls. The primary focus of the SWC is to inform site developers on how well they can meet a desired stormwater retention target with and without the use of green infrastructure. It can also be used by landscapers and homeowners. Platform. The SWC is a Windows-based desktop program that requires an internet connection. A mobile web application version that will be compatible with all operating systems is currently being developed and is expected to be released in the fall of 2017.Cost Module. An LID cost estimation module within the application allows planners and managers to evaluate LID controls based on comparison of regional and national project planning level cost estimates (capital and average annual maintenance) and predicted LID control performance. Cost estimation is accomplished based on user-identified size configuration of the LID control infrastructure and other key project and site-specific variables. This includes whether the project is being applied as part of new development or redevelopment and if there are existing site constraints.Climate Scenarios. The SWC allows users to consider how runoff may vary based

Spontaneous Blinking from a Tribological Viewpoint.

PubMed

Pult, Heiko; Tosatti, Samuele G P; Spencer, Nicholas D; Asfour, Jean-Michel; Ebenhoch, Michael; Murphy, Paul J

2015-07-01

The mechanical forces between the lid wiper and the ocular surface, and between a contact lens and the lid wiper, are reported to be related to dry eye symptoms. Furthermore, the mechanical forces between these sliding partners are assumed to be related to the ocular signs of lid-wiper epitheliopathy (LWE) and lid-parallel conjunctival folds (LIPCOF). Recent literature provides some evidence that a contact lens with a low coefficient of friction (CoF) improves wearing comfort by reducing the mechanical forces between the contact lens surface and the lid wiper. This review discusses the mechanical forces during spontaneous blinks from a tribological perspective, at both low and high sliding velocities, in a healthy subject. It concludes that the coefficient of friction of the ocular surfaces appears to be strongly comparable to that of hydrophilic polymer brushes at low sliding velocity, and that, with increased sliding velocity, there is no wear at the sliding partners' surfaces thanks to the presence of a fluid film between the two sliding partners. In contrast, in the case of dry eye, the failure to maintain a full fluid film lubrication regime at high blinking speeds may lead to increased shear rates, resulting in deformation and wear of the sliding pairs. These shear rates are most likely related to tear film viscosity. Copyright © 2015 Elsevier Inc. All rights reserved.

Eyelid reconstruction: the state of the art.

PubMed

Verity, David H; Collin, J Richard O

2004-08-01

The goals of eyelid reconstruction are corneal protection, restoration of the integrity of the lid lamellae, and improvement of facial symmetry. Inadequate reconstruction may lead to corneal exposure and sight-threatening keratopathy; in the younger patient, visual deprivation and amblyopia may also follow. The purpose of this review is to describe new materials and approaches used in reconstructing the damaged eyelid. Although the surgical principles of lid reconstruction remain unchallenged, new materials and techniques have emerged. These include the use of both autogenous and cadaveric acellular dermis in the management of lower eyelid retraction, and amniotic membrane transplantation in the management of tarsal conjunctival disease. Recent work on upper facial nerve branch reinnervation in the animal model may also offer hope for eyelid reanimation after facial palsy. The lid surgeon requires a sound knowledge of the principles involved in reconstructing the respective lamellae of the lid. Anterior lamellar reconstruction carries a significant risk of ectropion, and large defects may require several interposition flaps for optimum skin texture and color reconstruction. New materials (autogenous and cadaveric) for posterior lid reconstruction may reduce donor site morbidity and surgical time, but they may contract significantly after surgery. Recent experience with amniotic membrane transplantation may improve the prognosis for patients with entropion and symblepharon caused by conjunctival cicatricial changes.

Multiple approaches to valuation of conservation design and low-impact development features in residential subdivisions.

PubMed

Bowman, Troy; Tyndall, John C; Thompson, Janette; Kliebenstein, James; Colletti, Joe P

2012-08-15

Residents, developers and civic officials are often faced with difficult decisions about appropriate land uses in and around metropolitan boundaries. Urban expansion brings with it the potential for negative environmental impacts, but there are alternatives, such as conservation subdivision design (CSD) or low-impact development (LID), which offer the possibility of mitigating some of these effects at the development site. Many urban planning jurisdictions across the Midwest do not currently have any examples of these designs and lack information to identify public support or barriers to use of these methods. This is a case study examining consumer value for conservation and low-impact design features in one housing market by using four different valuation techniques to estimate residents' willingness to pay for CSD and LID features in residential subdivisions. A contingent valuation survey of 1804 residents in Ames, IA assessed familiarity with and perceptions of subdivision development and used an ordered value approach to estimate willingness to pay for CSD and LID features. A majority of residents were not familiar with CSD or LID practices. Residents indicated a willingness to pay for most CSD and LID features with the exception of clustered housing. Gender, age, income, familiarity with LID practices, perceptions of attractiveness of features and the perceived effect of CSD and LID features on ease of future home sales were important factors influencing residents' willingness to pay. A hypothetical referendum measured willingness to pay for tax-funded conservation land purchases and estimated that a property tax of around $50 would be the maximum increase that would pass. Twenty-seven survey respondents participated in a subsequent series of experimental real estate negotiations that used an experimental auction mechanism to estimate willingness to pay for CSD and LID features. Participants indicated that clustered housing (with interspersed preserved forest or open space areas), rain gardens, and neighborhood streams with a forested buffer were the features they were most willing to pay for. Participants were not willing to pay for neighborhood streams without buffers. Finally, a spatial hedonic price model using 2093 homes in Ames, IA was used to estimate the effect of public and private open space on housing values. The model indicated that presence of neighborhood association-owned forest and water features as well as proximity to public parks had significant positive effects on housing prices. However, proximity to a public lake had a negative effect on home values. The four methods used in this study include both stated and revealed preference techniques. Although the relative magnitude of value expressed varied, all methods indicated that residents value CSD and LID subdivision features. Subdivision features that included explicit environmental benefits were also consistently preferred over features that did not. Familiarity with alternative designs was an important factor influencing resident willingness to pay for neighborhood features, and developers and civic officials should consider ways to educate citizens about CSD and LID development techniques to increase interest in these designs. Published by Elsevier Ltd.

Leadership Identity Development: Challenges in Applying a Developmental Model

ERIC Educational Resources Information Center

Komives, Susan R.; Longerbeam, Susan D.; Mainella, Felicia; Osteen, Laura; Owen, Julie E.; Wagner, Wendy

2009-01-01

The leadership identity development (LID) grounded theory (Komives, Owen, Longerbeam, Mainella, & Osteen, 2005) and related LID model (Komives, Longerbeam, Owen, Mainella, & Osteen, 2006) present a framework for understanding how individual college students develop the social identity of being collaborative, relational leaders…

46 CFR 160.022-4 - Approval and production tests.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 6 2011-10-01 2011-10-01 false Approval and production tests. 160.022-4 Section 160.022-4 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Floating Orange Smoke Distress Signals (5 Minutes) § 160.022-4 Approval and production test...

Multipurpose floating platform for hyperspectral imaging, sampling and sensing of surface water sources used in irrigation and recreation

USDA-ARS?s Scientific Manuscript database

The objective of this work was to design, construct, and test the self-propelled aquatic platform for imaging, multi-tier water sampling, water quality sensing, and depth profiling to document microbial content and environmental covariates in the interior of irrigation ponds and reservoirs. The plat...

Linking the Scales of Scientific inquiry and Watershed Management: A Focus on Green Infrastructure

NASA Astrophysics Data System (ADS)

Golden, H. E.; Hoghooghi, N.

2017-12-01

Urbanization modifies the hydrologic cycle, resulting in potentially deleterious downstream water quality and quantity effects. However, the cumulative interacting effects of water storage, transport, and biogeochemical processes occurring within other land cover and use types of the same watershed can render management explicitly targeted to limit the negative outcomes from urbanization ineffective. For example, evidence indicates that green infrastructure, or low impact development (LID), practices can attenuate the adverse water quality and quantity effects of urbanizing systems. However, the research providing this evidence has been conducted at local scales (e.g., plots, small homogeneous urban catchments) that isolate the measurable effects of such approaches. Hence, a distinct disconnect exists between the scale of scientific inquiry and the scale of management and decision-making practices. Here we explore the oft-discussed yet rarely directly addressed scientific and management conundrum: How do we scale our well-documented scientific knowledge of the water quantity and quality responses to LID practices measured and modeled at local scales to that of "actual" management scales? We begin by focusing on LID practices in mixed land cover watersheds. We present key concepts that have emerged from LID research at the local scale, considerations for scaling this research to watersheds, recent advances and findings in scaling the effects of LID practices on water quality and quantity at watershed scales, and the use of combined novel measurements and models for these scaling efforts. We underscore these concepts with a case study that evaluates the effects of three LID practices using simulation modeling across a mixed land cover watershed. This synthesis and case study highlight that scientists are making progress toward successfully tailoring fundamental research questions with decision-making goals in mind, yet we still have a long road ahead.

A Multi-criteria Decision Analysis System for Prioritizing Sites and Types of Low Impact Development Practices

NASA Astrophysics Data System (ADS)

Song, Jae Yeol; Chung, Eun-Sung

2017-04-01

This study developed a multi-criteria decision analysis framework to prioritize sites and types of low impact development (LID) practices. This framework was systemized as a web-based system coupled with the Storm Water Management Model (SWMM) from the Environmental Protection Agency (EPA). Using the technique for order of preference by similarity to ideal solution (TOPSIS), which is a type of multi-criteria decision-making (MCDM) method, multiple types and sites of designated LID practices are prioritized. This system is named the Water Management Prioritization Module (WMPM) and is an improved version of the Water Management Analysis Module (WMAM) that automatically generates and simulates multiple scenarios of LID design and planning parameters for a single LID type. WMPM can simultaneously determine the priority of multiple LID types and sites. In this study, an infiltration trench and permeable pavement were considered for multiple sub-catchments in South Korea to demonstrate the WMPM procedures. The TOPSIS method was manually incorporated to select the vulnerable target sub-catchments and to prioritize the LID planning scenarios for multiple types and sites considering socio-economic, hydrologic and physical-geometric factors. In this application, the Delphi method and entropy theory were used to determine the subjective and objective weights, respectively. Comparing the ranks derived by this system, two sub-catchments, S16 and S4, out of 18 were considered to be the most suitable places for installing an infiltration trench and porous pavement to reduce the peak and total flow, respectively, considering both socio-economic factors and hydrological effectiveness. WMPM can help policy-makers to objectively develop urban water plans for sustainable development. Keywords: Low Impact Development, Multi-Criteria Decision Analysis, SWMM, TOPSIS, Water Management Prioritization Module (WMPM)

The effects of low impact development on urban flooding under different rainfall characteristics.

PubMed

Qin, Hua-peng; Li, Zhuo-xi; Fu, Guangtao

2013-11-15

Low impact development (LID) is generally regarded as a more sustainable solution for urban stormwater management than conventional urban drainage systems. However, its effects on urban flooding at a scale of urban drainage systems have not been fully understood particularly when different rainfall characteristics are considered. In this paper, using an urbanizing catchment in China as a case study, the effects of three LID techniques (swale, permeable pavement and green roof) on urban flooding are analyzed and compared with the conventional drainage system design. A range of storm events with different rainfall amounts, durations and locations of peak intensity are considered for holistic assessment of the LID techniques. The effects are measured by the total flood volume reduction during a storm event compared to the conventional drainage system design. The results obtained indicate that all three LID scenarios are more effective in flood reduction during heavier and shorter storm events. Their performance, however, varies significantly according to the location of peak intensity. That is, swales perform best during a storm event with an early peak, permeable pavements perform best with a middle peak, and green roofs perform best with a late peak, respectively. The trends of flood reduction can be explained using a newly proposed water balance method, i.e., by comparing the effective storage depth of the LID designs with the accumulative rainfall amounts at the beginning and end of flooding in the conventional drainage system. This paper provides an insight into the performance of LID designs under different rainfall characteristics, which is essential for effective urban flood management. Copyright © 2013 Elsevier Ltd. All rights reserved.

Complications and outcomes of grafting of posterior orbital fat into the lower lid-cheek junction during orbital decompression.

PubMed

Litwin, Andre S; Poitelea, Cornelia; Tan, Petrina; Ziahosseini, Kimia; Malhotra, Raman

2018-04-01

To report the complications of grafting of excised posterior orbital fat into the lower lid-cheek junction at the time of orbital decompression surgery. Retrospective review of consecutive patients undergoing orbital decompression combined with grafting of posterior orbital fat to the pre-malar and lateral canthal area (FG). A second group of consecutive patients undergoing orbital decompression but no orbital fat grafting (NoFG) were also studied as a form of comparative control. Standard patient data, including age, sex, visual acuity, degree of proptosis, operative details, diplopia or any other complications was collected. Independent assessment of pre- and post-operative photographs graded the lower lid-cheek junction. Thirty-four orbits of 29 patients, of which 21 orbits underwent orbital decompression with orbital fat grafting (FG). There were no intraoperative complications, postoperative infections, or visual loss. Complications relating to fat grafting included prolonged swelling in 3 (17%) patients at 3 months, in 1 case lasting 6 months, lower lid lumps in 3 (17%), and fat seepage in 1 (6%). The FG group achieved a greater improvement in the appearance of the lower-lid-cheek junction at 12 months in comparison to NoFG. Mean grade improvement 1.24 ± 1.09 vs 0 ± 0.82 (p = 0.025). Median follow-up was 20 months (range 6-30 months). Grafting of excised orbital fat during orbital decompression can improve the appearance of the lower lid-cheek junction in patients being treated for thyroid orbitopathy. However, 24% of patients will experience swelling and/or lumpiness requiring several months to settle or further fat excision.

Water-Pressure Distribution on Seaplane Float

NASA Technical Reports Server (NTRS)

Thompson, F L

1929-01-01

The investigation presented in this report was conducted for the purpose of determining the distribution and magnitude of water pressures likely to be experienced on seaplane hulls in service. It consisted of the development and construction of apparatus for recording water pressures lasting one one-hundredth second or longer and of flight tests to determine the water pressures on a UO-1 seaplane float under various conditions of taxiing, taking off, and landing. The apparatus developed was found to operate with satisfactory accuracy and is suitable for flight tests on other seaplanes. The tests on the UO-1 showed that maximum pressures of about 6.5 pounds per square inch occur at the step for the full width of the float bottom. Proceeding forward from the step the maximum pressures decrease in magnitude uniformly toward the bow, and the region of highest pressures narrows toward the keel. Immediately abaft the step the maximum pressures are very small, but increase in magnitude toward the stern and there once reached a value of about 5 pounds per square inch. (author)

Floating Offshore Wind in Oregon: Potential for Jobs and Economic Impacts from Two Future Scenarios

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jimenez, Tony; Keyser, David; Tegen, Suzanne

Construction of the first offshore wind power plant in the United States began in 2015, off the coast of Rhode Island, using fixed platform structures that are appropriate for shallow seafloors, like those located off of the East Coast and mid-Atlantic. However, floating platforms, which have yet to be deployed commercially, will likely need to anchor to the deeper seafloor if deployed off of the West Coast. To analyze the employment and economic potential for floating offshore wind along the West Coast, the Bureau of Ocean Energy Management (BOEM) commissioned the National Renewable Energy Laboratory (NREL) to analyze two hypothetical,more » large-scale deployment scenarios for Oregon: 5,500 megawatts (MW) of offshore wind deployment in Oregon by 2050 (Scenario A), and 2,900 MW of offshore wind by 2050 (Scenario B). These levels of deployment could power approximately 1,600,000 homes (Scenario A) or 870,000 homes (Scenario B). Offshore wind would contribute to economic development in Oregon in the near future, and more substantially in the long term, especially if equipment and labor are sourced from within the state. According to the analysis, over the 2020-2050 period, Oregon floating offshore wind facilities could support 65,000-97,000 job-years and add $6.8 billion-$9.9 billion to the state GDP (Scenario A).« less

[Culture of pancreatic progenitor cells in hanging drop and on floating filter].

PubMed

Ma, Feng-xia; Chen, Fang; Chi, Ying; Yang, Shao-guang; Lu, Shi-hong; Han, Zhong-chao

2013-06-01

To construct a method to culture pancreatic progenitor cells in hanging drop and on floating filter,and to examine if pancreatic progenitor cells can differentiate into mature endocrine cells with this method. Murine embryos at day 12.5 were isolated and digested into single cells,which were then cultured in hanging drop for 24h and formed spheres.Spheres were cultured on the filter for 6 days,which floated in the dish containing medium.During culture,the expressions of pancreas duodenum homeobox-1(PDX-1)and neurogenin3(Ngn3)were determined.The expressions of endocrine and exocrine markers,insulin,glucagon,and carboxypeptidase(CPA)were determined on day 7 by immunohistochemistry.Insulin secretion of spheres stimulated by glucose was detected by ELISA.The changes of pancreatic marker expressions during culture were monitored by real-time polymerase chain reaction(PCR). One day after the culture,there were still a large amount of PDX-1 positive cells in pancreatic spheres,and these cells proliferated.On day 3,high expression of Ngn3 was detected,and the Ngn3-positive cells did not proliferate.On day 7,The expressions of endocrine and exocrine markers in the differentiated pancreatic progenitor cells were detected,which were consistent with that in vivo.Insulin was secreted by spheres upon the stimulation of glucose. In hanging drop and on floating filter,pancreatic progenitor cells can differentiate into mature endocrine cells.

Critical Review of Technical Questions Facing Low Impact Development and Green Infrastructure: A Perspective from the Great Plains.

PubMed

Vogel, Jason R; Moore, Trisha L; Coffman, Reid R; Rodie, Steven N; Hutchinson, Stacy L; McDonough, Kelsey R; McLemore, Alex J; McMaine, John T

2015-09-01

Since its inception, Low Impact Development (LID) has become part of urban stormwater management across the United States, marking progress in the gradual transition from centralized to distributed runoff management infrastructure. The ultimate goal of LID is full, cost-effective implementation to maximize watershed-scale ecosystem services and enhance resilience. To reach that goal in the Great Plains, the multi-disciplinary author team presents this critical review based on thirteen technical questions within the context of regional climate and socioeconomics across increasing complexities in scale and function. Although some progress has been made, much remains to be done including continued basic and applied research, development of local LID design specifications, local demonstrations, and identifying funding mechanisms for these solutions. Within the Great Plains and beyond, by addressing these technical questions within a local context, the goal of widespread acceptance of LID can be achieved, resulting in more effective and resilient stormwater management.

On the Rigid-Lid Approximation for Two Shallow Layers of Immiscible Fluids with Small Density Contrast

NASA Astrophysics Data System (ADS)

Duchêne, Vincent

2014-08-01

The rigid-lid approximation is a commonly used simplification in the study of density-stratified fluids in oceanography. Roughly speaking, one assumes that the displacements of the surface are negligible compared with interface displacements. In this paper, we offer a rigorous justification of this approximation in the case of two shallow layers of immiscible fluids with constant and quasi-equal mass density. More precisely, we control the difference between the solutions of the Cauchy problem predicted by the shallow-water (Saint-Venant) system in the rigid-lid and free-surface configuration. We show that in the limit of a small density contrast, the flow may be accurately described as the superposition of a baroclinic (or slow) mode, which is well predicted by the rigid-lid approximation, and a barotropic (or fast) mode, whose initial smallness persists for large time. We also describe explicitly the first-order behavior of the deformation of the surface and discuss the case of a nonsmall initial barotropic mode.

Unveiling the nucleon tensor charge at Jefferson Lab: A study of the SoLID case

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ye, Zhihong; Sato, Nobuo; Allada, Kalyan

2017-01-27

Here, future experiments at the Jefferson Lab 12 GeV upgrade, in particular, the Solenoidal Large Intensity Device (SoLID), aim at a very precise data set in the region where the partonic structure of the nucleon is dominated by the valence quarks. One of the main goals is to constrain the transversity quark distributions. We apply recent theoretical advances of the global QCD extraction of the transversity distributions to study the impact of future experimental data from the SoLID. Especially, we develop a model-independent method based on the hessian matrix analysis that allows to estimate the uncertainties of the transversity quarkmore » distributions and their tensor charge contributions extracted from the pseudo-data for the SoLID. Both u and d-quark transversity distributions are shown to be very well constrained in the kinematical region of the future experiments with the proton and the effective neutron targets.« less

The influence of mantle refertilisation on the formation of TTGs in a plume-lid tectonics setting

NASA Astrophysics Data System (ADS)

Fischer, R.; Gerya, T.

2017-12-01

Higher amounts of radiogenic elements and leftover primordial heat in the early Earth both contribute to the increased temperature in the Earth's interior and it is mainly this increased mantle potential temperature that controls the dynamics of the crust and upper mantle and the predominant style of tectonics in the Early Earth. The increased upper mantle temperature precludes the modern plate tectonics regime and stabilizes another type of global tectonics often called plume-lid tectonics (Fischer and Gerya, 2016) or 'plutonic squishy lid' tectonics(Rozel et al., 2017). Plume-lid tectonics is dominated by intrusive mantle-derived magmatism which results in a thickening of the overlaying crust. The overthickened basaltic crust is transformed into eclogite and episodically recycled back into the mantle. Melt extraction from hydrated partially molten basaltic crust leads to the production of primordial tonalite-trondhjemite-granodiorite (TTG) continental crust. TTGs make up over half of the Archean crust and can be classied into low-, medium- and high-pressure types (Moyen, 2011). Field studies show that the three different types (low-, medium- and high-pressure) appear in a ratio of 20%, 60% and 20% (Moyen, 2011). Numerical models of plume-lid tectonics generally agree very well with these values (Rozel et al., 2017) but also show that the ratio between the three different TTG types varies greatly during the two phases of the plume-lid tectonics cycle: growth phase and overturn phase. Melt productivity of the mantle decreases rapidly after removal of the garnet and clinopyroxene components. Addition of new garnet and clinopyroxene-rich material into the harzburgitic residue should lead to a refertilised lherzolite which could potentially yield new melt (Bédard, 2006). Mixing of eclogite drips back into the mantle can lead to the geochemical refertilisation of already depleted mantle and allow for further extraction of melt (Bédard, 2006). We will explore this process of mantle refertilisation in our 3D petrological-magmatic-thermomechanical numerical modelling experiments and study its influence on the three types of TTGs during different phases of the plume-lid tectonics cycle.

Testing and use of radar water level sensors by the U.S. Geological Survey

USGS Publications Warehouse

Fulford, Janice M.

2016-01-01

The United States Geological Survey uses water-level (or stage) measurements to compute streamflow at over 8000 stream gaging stations located throughout the United States (waterwatch.usgs.gov, 2016). Streamflow (or discharge) is computed at five minute to hourly intervals from a relationship between water level and discharge that is uniquely determined for each station. The discharges are posted hourly to WaterWatch (waterwatch. usgs.gov) and are used by water managers to issue flood warnings and manage water supply and by other users of water information to make decisions. The accuracy of the water-level measurement is vital to the accuracy of the computed discharge. Because of the importance of water-level measurements, USGS has an accuracy policy of 0.02 ft or 0.2 percent of reading (whichever is larger) (Sauer and Turnipseed, 2010). Older technologies, such as float and shaft-encoder systems, bubbler systems and submersible pressure sensors, provide the needed accuracy but often require extensive construction to install and are prone to malfunctioning and damage from floating debris and sediment. No stilling wells or orifice lines need to be constructed for radar installations. During the last decade testing by the USGS Hydrologic Instrumentation Facility(HIF) found that radar water-level sensors can provide the needed accuracy for water-level measurements and because the sensor can be easily attached to bridges, reduce the construction required for installation. Additionally, the non-contact sensing of water level minimizes or eliminates damage and fouling from floating debris and sediment. This article is a brief summary of the testing efforts by the USGS HIF and field experiences with models of radar water-level sensors in streamflow measurement applications. Any use of trade names in this article is for descriptive purposes only and does not imply endorsement by the U.S. Government.

Segregation of isotopes of heavy metals due to light-induced drift: results and problems

NASA Astrophysics Data System (ADS)

Sapar, A.; Aret, A.; Poolamäe, R.; Sapar, L.

2008-04-01

Atutov and Shalagin (1988) proposed light-induced drift (LID) as a physically well understandable mechanism to explain the formation of isotopic anomalies observed in CP stars. We have generalized the theory of LID and applied it to diffusion of heavy elements and their isotopes in quiescent atmospheres of CP stars. Diffusional segregation of isotopes of chemical elements is described by the equations of continuity and diffusion velocity. Computations of evolutionary sequences for the abundances of mercury isotopes in several model atmospheres have been made, using the Fortran 90 program SMART composed by the authors. Results confirm predominant role of LID in separation of isotopes.

Water Quality Performance of Three Side-by-Side Permeable Pavement Surface Materials: Three Year Update

EPA Science Inventory

Communities are increasingly installing structural low impact development (LID) practices to mange stormwater and reduce pollutant loads associated with stormwater runoff. Permeable pavement is a LID practice that has limited research on working-scale, side-by-side performance o...

Identifying priority sites for low impact development (LID) in a mixed-use watershed

EPA Science Inventory

ABSTRACT: Low impact development (LID), a comprehensive land use planning and design approach with the goal of mitigating land development impacts to the environment, is increasingly being touted as an effective approach to lessen runoff and pollutant loadings to streams. Broad-s...

Complex solution of problem of all-season construction of roads and pipelines on universal composite pontoon units

NASA Astrophysics Data System (ADS)

Ryabkov, A. V.; Stafeeva, N. A.; Ivanov, V. A.; Zakuraev, A. F.

2018-05-01

A complex construction consisting of a universal floating pontoon road for laying pipelines in automatic mode on its body all year round and in any weather for Siberia and the Far North has been designed. A new method is proposed for the construction of pipelines on pontoon modules, which are made of composite materials. Pontoons made of composite materials for bedding pipelines with track-forming guides for automated wheeled transport, pipelayer, are designed. The proposed system eliminates the construction of a road along the route, ensures the buoyancy and smoothness of the self-propelled automated stacker in the form of a "centipede", which has a number of significant advantages in the construction and operation of the entire complex in the swamp and watered areas without overburden.

Lid wiper microvascular responses as an indicator of contact lens discomfort

PubMed Central

Deng, Zhihong; Wang, Jianhua; Jiang, Hong; Fadli, Zohra; Liu, Che; Tan, Jia; Zhou, Jin

2016-01-01

Purpose To analyze quantitatively the alterations in the microvascular network of the upper tarsal conjunctiva, lid wiper, and bulbar conjunctiva relative to ocular discomfort after contact lens wear. Design A prospective, cross-over clinical study. Methods Functional slit-lamp biomicroscopy (FSLB) was used to image the microvascular network of the upper tarsal conjunctiva, lid wiper, and bulbar conjunctiva. The microvascular network was automatically segmented, and fractal analyses were performed to yield the fractal dimension (Dbox) that represented vessel density. Sixteen healthy subjects (nine female and seven male) with an average age of 35.5 ± 6.7 years old (mean ± standard deviation) were recruited. The right eye was imaged at 9 AM and 3 PM at the first visit (Day 1) when the subject was not wearing contact lenses. During the second visit (Day 2), the right eye was fit with a contact lens for 6 h. Microvascular imaging was performed before (at 9 AM) and after lens wear (at 3 PM). Ocular comfort was rated using a 50-point visual analogue scale before and after 6 h of lens wear, and its relationships with microvascular parameters were analyzed. Results There were no significant differences in Dbox among the upper tarsal conjunctiva, lid wiper, and bulbar conjunctiva among the measurements at 9 AM (Day 1 and Day 2) and 3 PM (Day 1) when the subjects were not wearing the lenses (P > 0.05), whereas after 6 h of lens wear, the microvascular network densities were increased in all three of these locations. Dbox of the lid wiper increased from 1.411 ± 0.116 to 1.548 ± 0.079 after 6 h of contact lens wear (P < 0.01). Dbox of the tarsal conjunctiva was 1.731 ± 0.026 at baseline and increased to 1.740 ± 0.030 (P < 0.05). Dbox of the bulbar conjunctiva increased from 1.587 ± 0.059 to 1.632 ± 0.060 (P < 0.001). The decrease in ocular discomfort was strongly related to the Dbox change in the lid wiper (r = 0.61, P < 0.05). There were no correlations between the changes of ocular comfort and the microvascular network densities of either the tarsal or bulbar conjunctivas (P > 0.05). Conclusion This study is the first to show that the microvascular network of the lid wiper can be quantitatively analyzed in contact lens wearers. The microvascular responses of the lid wiper were significantly correlated with contact lens discomfort. PMID:27542928

Modeling watershed-scale impacts of stormwater management with traditional versus low impact development design

USGS Publications Warehouse

Sparkman, Stephanie A.; Hogan, Dianna; Hopkins, Kristina G.; Loperfido, J. V.

2017-01-01

Stormwater runoff and associated pollutants from urban areas in the greater Chesapeake Bay Watershed (CBW) impair local streams and downstream ecosystems, despite urbanized land comprising only 7% of the CBW area. More recently, stormwater best management practices (BMPs) have been implemented in a low impact development (LID) manner to treat stormwater runoff closer to its source. This approach included the development of a novel BMP model to compare traditional and LID design, pioneering the use of comprehensively digitized storm sewer infrastructure and BMP design connectivity with spatial patterns in a geographic information system at the watershed scale. The goal was to compare total watershed pollutant removal efficiency in two study watersheds with differing spatial patterns of BMP design (traditional and LID), by quantifying the improved water quality benefit of LID BMP design. An estimate of uncertainty was included in the modeling framework by using ranges for BMP pollutant removal efficiencies that were based on the literature. Our model, using Monte Carlo analysis, predicted that the LID watershed removed approximately 78 kg more nitrogen, 3 kg more phosphorus, and 1,592 kg more sediment per square kilometer as compared with the traditional watershed on an annual basis. Our research provides planners a valuable model to prioritize watersheds for BMP design based on model results or in optimizing BMP selection.

Lower Lid Laxity is Negatively Correlated with Improvement of the Ocular Surface Disease Index in Dry Eye Treatment.

PubMed

Oh, Seung Hoon; Lyu, Byul; Yim, Hye Bin; Lee, Na Young

2016-01-01

To compare the responses to dry eye treatment of patients sorted by the degree of lower lid laxity. Sixty patients were grouped into three groups according to the degree of lower lid laxity. Tear break-up time (TBUT), Schirmer test (ST) scores, ocular surface disease index (OSDI) scores, and changes in OSDI score in each group were compared, before and at 3 months after treatment. TBUT, ST, and OSDI scores were not different among the three groups at baseline. TBUT improved in each group at 3 months after treatment, and no differences between groups were found. ST scores were not increased after treatment, while OSDI were improved to 22.57 ± 5.243, 31.16 ± 11.353, and 37.85 ± 13.342 in the no, moderate, and high laxity groups, respectively; these improvements were statistically significant (p = 0.003, <0.001, <0.001, respectively). Patients with greater than moderate lower lid laxity saw the smallest improvement in response to dry eye treatment, as assessed by change in OSDI score (p = 0.005 versus moderate laxity group, p = 0.005 versus no laxity group). Lower lid laxity is one of the factors contributing to the responses to dry eye treatment assessed by change in OSDI score, independent of TBUT and ST scores.

Application of the laser induced deflection (LID) technique for low absorption measurements in bulk materials and coatings

NASA Astrophysics Data System (ADS)

Triebel, W.; Mühlig, C.; Kufert, S.

2005-10-01

Precise absorption measurements of bulk materials and coatings upon pulsed ArF laser irradiation are presented using a compact experimental setup based on the laser induced deflection technique (LID). For absorption measurements of bulk materials the influence of pure bulk and pure surface absorption on the temperature and refractive index profile and thus for the probe beam deflection is analyzed in detail. The separation of bulk and surface absorption via the commonly used variation of the sample thickness is carried out for fused silica and calcium fluoride. The experimental results show that for the given surface polishing quality the bulk absorption coefficient of fused silica can be obtained by investigating only one sample. To avoid the drawback of different bulk and surface properties amongst a thickness series, we propose a strategy based on the LID technique to generally obtain surface and bulk absorption separately by investigating only one sample. Apart from measuring bulk absorption coefficients the LID technique is applied to determine the absorption of highly reflecting (HR) coatings on CaF2 substrates. Beside the measuring strategy the experimental results of a AlF3/LaF3 based HR coating are presented. In order to investigate a larger variety of coatings, including high transmitting coatings, a general measuring strategy based on the LID technique is proposed.

Objective Brow Height Measurements Following Pretrichial Brow Lift and Upper Lid Blepharoplasty.

PubMed

Martin, Matthew; Shah, Christopher T; Attawala, Payal; Neaman, Keith; Meldrum, Melissa; Hassan, Adam S

2016-01-01

As the ptotic brow drops below the supraorbital rim, it can exacerbate dermatochalasis by pushing the adjacent skin of the upper lid further down. The purpose of this study was to evaluate the outcomes associated with a combined pretrichial brow lift and upper lid blepharoplasty in patients with dermatochalasis and mild to moderate brow ptosis. A retrospective case series of 46 patients with dermatochalasis and mild to moderate brow ptosis treated with a combined, bilateral pretrichial brow lift and upper lid blepharoplasty from January 2008 to December 2011. Main outcome measures included measurements of brow lift at 3 months post-operatively, complications encountered, patient satisfaction and surgeon satisfaction. Outcomes from 46 patients were evaluated. The mean brow lift was 1.85 mm at the lateral canthus, 1.54 mm at the lateral limbus, 1.31 mm at the mid-pupil, and 1.07 mm at the medial limbus. Brow lift at the lateral canthus was significantly more elevated than at the medial limbus (P < 0.001). Minor complications were encountered in seven of 46 patients (15.2%). Mean patient satisfaction score was 3.20 and surgeon satisfaction 3.24 (max = 4, very satisfied). The modified pretrichial brow lift offered effective lateral lift that complements an upper lid blepharoplasty. This technique was met with a high degree of patient and surgeon satisfaction, and had a minimal complication profile.

Dyskinesias and impulse control disorders in Parkinson's disease: From pathogenesis to potential therapeutic approaches.

PubMed

Jiménez-Urbieta, Haritz; Gago, Belén; de la Riva, Patricia; Delgado-Alvarado, Manuel; Marin, Concepció; Rodriguez-Oroz, María C

2015-09-01

Dopaminergic treatment in Parkinson's disease (PD) reduces the severity of motor symptoms of the disease. However, its chronic use is associated with disabling motor and behavioral side effects, among which levodopa-induced dyskinesias (LID) and impulse control disorders (ICD) are the most common. The underlying mechanisms and pathological substrate of these dopaminergic complications are not fully understood. Recently, the refinement of imaging techniques and the study of the genetics and molecular bases of LID and ICD indicate that, although different, they could share some features. In addition, animal models of parkinsonism with LID have provided important knowledge about mechanisms underlying such complications. In contrast, animal models of parkinsonism and abnormal impulsivity, although useful regarding some aspects of human ICD, do not fully resemble the clinical phenotype of ICD in patients with PD, and until now have provided limited information. Studies on animal models of addiction could complement the previous models and provide some insights into the background of these behavioral complications given that ICD are regarded as behavioral addictions. Here we review the most relevant advances in relation to imaging, genetics, biochemistry and pharmacological interventions to treat LID and ICD in patients with PD and in animal models with a view to better understand the overlapping and unique maladaptations to dopaminergic therapy that are associated with LID and ICD. Copyright © 2015 Elsevier Ltd. All rights reserved.

Initial Results from the Floating Potential Measurement Unit aboard the International Space Station

NASA Technical Reports Server (NTRS)

Wright, Kenneth H., Jr.; Swenson, Charles; Thompson, Don; Barjatya, Aroh; Koontz, Steven L.; Schneider, Todd; Vaughn, Jason; Minow, Joseph; Craven, Paul; Coffey, Victoria;

Melting-induced crustal production helps plate tectonics on Earth-like planets

NASA Astrophysics Data System (ADS)

Lourenço, Diogo L.; Rozel, Antoine; Tackley, Paul J.

2016-04-01

Within our Solar System, Earth is the only planet to be in a mobile-lid regime. It is generally accepted that the other terrestrial planets are currently in a stagnant-lid regime, with the possible exception of Venus that may be in an episodic-lid regime (Armann and Tackley, JGR 2012). Using plastic yielding to self-consistently generate plate tectonics on an Earth-like planet with strongly temperature-dependent viscosity is now well-established, but such models typically focus on purely thermal convection, whereas compositional variations in the lithosphere can alter the stress state and greatly influence the likelihood of plate tectonics. For example, Rolf and Tackley (GRL, 2011) showed that the addition of a continent can reduce the critical yield stress for mobile-lid behaviour by a factor of around two. Moreover, it has been shown that the final tectonic state of the system can depend on the initial condition (Tackley, G3 2000 - part 2). Weller and Lenardic (GRL, 2012) found that the parameter range in which two solutions are obtained increases with viscosity contrast. We can also say that partial melting has a major role in the long-term evolution of rocky planets: (1) partial melting causes differentiation in both major elements and trace elements, which are generally incompatible (Hofmann, Nature 1997). Trace elements may contain heat-producing isotopes, which contribute to the heat loss from the interior; (2) melting and volcanism are an important heat loss mechanism at early times that act as a strong thermostat, buffering mantle temperatures and preventing it from getting too hot (Xie and Tackley, JGR 2004b); (3) mantle melting dehydrates and hardens the shallow part of the mantle (Hirth and Kohlstedt, EPSL 1996) and introduces viscosity and compositional stratifications in the shallow mantle due to viscosity variations with the loss of hydrogen upon melting (Faul and Jackson, JGR 2007; Korenaga and Karato, JGR 2008). We present a set of 2D spherical annulus simulations (Hernlund and Tackley, PEPI 2008) using StagYY (Tackley, PEPI 2008), which uses a finite-volume scheme for advection of temperature, a multigrid solver to obtain a velocity-pressure solution at each timestep, tracers to track composition, and a treatment of partial melting and crustal formation. We address the question of whether melting-induced crustal production changes the critical yield stress needed to obtain mobile-lid behaviour (plate tectonics). Our results show that melting-induced crustal production strongly influences plate tectonics on Earth-like planets by strongly enhancing the mobility of the lid, replacing a stagnant lid with an episodic lid, or greatly extending the time in which a smoothly evolving mobile lid is present in a planet. Finally, we show that our results are consistent with analytically predicted critical yield stress obtained with boundary layer theory, whether melting-induced crustal production is considered or not.

A new framework for modeling decentralized low impact developments using Soil and Water Assessment Tool

USDA-ARS?s Scientific Manuscript database

Assessing the performance of Low Impact Development (LID) practices at a catchment scale is important in managing urban watersheds. Few modeling tools exist that are capable of explicitly representing the hydrological mechanisms of LIDs while considering the diverse land uses of urban watersheds. ...

Role of Importance and Distinctiveness of Semantic Features in People with Aphasia: A Replication Study

ERIC Educational Resources Information Center

Mason-Baughman, Mary Beth; Wallace, Sarah E.

2014-01-01

Previous studies suggest that people with aphasia have incomplete lexical-semantic representations with decreased low-importance distinctive (LID) feature knowledge. In addition, decreased LID feature knowledge correlates with ability to discriminate among semantically related words. The current study seeks to replicate and extend previous…

A Review of Applicability and Effectiveness of Low Impact Development/Green Infrastructure Practices in Arid/Semi-Arid United States

EPA Science Inventory

Southwestern/Western United States is among the fastest growing urbanized area and faces multiple water resource challenges. Low Impact Development (LID) /Green Infrastructure (GI) practices are increasingly popular technologies for managing stormwater; however, LID is often not ...

Recent developments in the construction and operation of all-metal airplanes

NASA Technical Reports Server (NTRS)

Dornier, C

1926-01-01

Experiments on the effect of atmosphere and of sea water on the building materials employed by us have been carried on for years in the North Sea with the aid of the Hamburg Naval Observatory. Parallel experiments are being made at the Pisa Naval Observatory in the Mediterranean Sea. Metal sheets, sections, assemblies and experimental floats are being exposed to the action of the elements. Different construction techniques are discussed and a variety of specific airplanes are presented which incorporate some of the new thinking.

The Impact of Occupational Stress on University Employees' Personality

ERIC Educational Resources Information Center

Ahmad, Nawaz; Ashraf, Muhammad

2016-01-01

This study is an effort to understand the impact of occupational stress which is classified into four constructs i.e. pressure at work, support at work, job satisfaction, and nature of job, on the personality of employees working in public as well as private sector universities. To conduct the study, a survey questionnaire was floated to six…

Critical path method applied to research project planning: Fire Economics Evaluation System (FEES)

Treesearch

Earl B. Anderson; R. Stanton Hales

1986-01-01

The critical path method (CPM) of network analysis (a) depicts precedence among the many activities in a project by a network diagram; (b) identifies critical activities by calculating their starting, finishing, and float times; and (c) displays possible schedules by constructing time charts. CPM was applied to the development of the Forest Service's Fire...

Binding and Scope Dependencies with "Floating Quantifiers" in Japanese

ERIC Educational Resources Information Center

Mukai, Emi

2012-01-01

The primary concern of this thesis is how we can achieve rigorous testability when we set the properties of the Computational System (hypothesized to be at the center of the language faculty) as our object of inquiry and informant judgments as a tool to construct and/or evaluate our hypotheses concerning the properties of the Computational System.…

Scrap tyre recycling process with molten zinc as direct heat transfer and solids separation fluid: A new reactor concept.

PubMed

Riedewald, Frank; Goode, Kieran; Sexton, Aidan; Sousa-Gallagher, Maria J

2016-01-01

Every year about 1.5 billion tyres are discarded worldwide representing a large amount of solid waste, but also a largely untapped source of raw materials. The objective of the method was to prove the concept of a novel scrap tyre recycling process which uses molten zinc as the direct heat transfer fluid and, simultaneously, uses this media to separate the solids products (i.e. steel and rCB) in a sink-float separation at an operating temperature of 450-470 °C. This methodology involved: •construction of the laboratory scale batch reactor,•separation of floating rCB from the zinc,•recovery of the steel from the bottom of the reactor following pyrolysis.

Physics of Failure Analysis of Xilinx Flip Chip CCGA Packages: Effects of Mission Environments on Properties of LP2 Underfill and ATI Lid Adhesive Materials

NASA Technical Reports Server (NTRS)

Suh, Jong-ook

2013-01-01

The Xilinx Virtex 4QV and 5QV (V4 and V5) are next-generation field-programmable gate arrays (FPGAs) for space applications. However, there have been concerns within the space community regarding the non-hermeticity of V4/V5 packages; polymeric materials such as the underfill and lid adhesive will be directly exposed to the space environment. In this study, reliability concerns associated with the non-hermeticity of V4/V5 packages were investigated by studying properties and behavior of the underfill and the lid adhesvie materials used in V4/V5 packages.

A Bipartite Interaction between Hsp70 and CHIP Regulates Ubiquitination of Chaperoned Client Proteins

DOE PAGES

Zhang, Huaqun; Amick, Joseph; Chakravarti, Ritu; ...

2015-02-12

The ubiquitin ligase CHIP plays an important role in cytosolic protein quality control by ubiquitinating proteins chaperoned by Hsp70/Hsc70 and Hsp90, thereby targeting such substrate proteins for degradation. We present a 2.91 Å resolution structure of the tetratricopeptide repeat (TPR) domain of CHIP in complex with the α-helical lid subdomain and unstructured tail of Hsc70. Surprisingly, the CHIP-TPR interacts with determinants within both the Hsc70-lid subdomain and the C-terminal PTIEEVD motif of the tail, exhibiting an atypical mode of interaction between chaperones and TPR domains. Here, we demonstrate that the interaction between CHIP and the Hsc70-lid subdomain is required formore » proper ubiquitination of Hsp70/Hsc70 or Hsp70/Hsc70-bound substrate proteins. Posttranslational modifications of the Hsc70 lid and tail disrupt key contacts with the CHIP-TPR and may regulate CHIP-mediated ubiquitination. Our study shows how CHIP docks onto Hsp70/Hsc70 and defines a bipartite mode of interaction between TPR domains and their binding partners.« less

Estimation of Stormwater Interception Rate for various LID Facilities

NASA Astrophysics Data System (ADS)

Kim, S.; Lee, O.; Choi, J.

2017-12-01

In this study, the stormwater interception rate is proposed to apply in the design of LID facilities. For this purpose, EPA-SWMM is built with some areas of Noksan National Industrial Complex where long-term observed stormwater data were monitored and stormwater interception rates for various design capacities of various LID facilities are estimated. While the sensitivity of stormwater interception rate according to design specifications of bio-retention and infiltration trench facilities is not large, the sensitivity of stormwater interception rate according to local rainfall characteristics is relatively big. As a result of comparing the present rainfall interception rate estimation method which is officially operated in Korea with the one proposed in this study, it will be presented that the present method is highly likely to overestimate the performance of the bio-retention and infiltration trench facilities. Finally, a new stormwater interception rate formulas for the bio-retention and infiltration trench LID facilities will be proposed. Acknowledgement This research was supported by a grant (2016000200002) from Public Welfare Technology Development Program funded by Ministry of Environment of Korean government.

Reanalysis of tritium production in a sphere of /sup 6/LiD irradiated by 14-MeV neutrons

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fawcett, L.R. Jr.

1985-08-01

Tritium production and activation of radiochemical detector foils in a sphere of /sup 6/LiD irradiated by a central source of 14-MeV neutrons has been reanalyzed. The /sup 6/LiD sphere consisted of 10 solid hemispherical nested shells with ampules of /sup 6/LiH, /sup 7/LiH, and activation foils located 2.2, 5, 7.7, 12.6, 20, and 30 cm from the center. The Los Alamos Monte Carlo Neutron Photon Transport Code (MCNP) was used to calculate neutron transport through the /sup 6/LiD, tritium production in the ampules, and foil activation. The MCNP input model was three-dimensional and employed ENDF/B-V cross sections for transport, tritiummore » production, and (where available) foil activation. The reanalyzed experimentally observed-to-calculated values of tritium production were 1.053 +- 2.1% in /sup 6/LiH and 0.999 +- 2.1% in /sup 7/LiH. The recalculated foil activation observed-to-calculated ratios were not generally improved over those reported in the original analysis.« less

Levodopa/benserazide microsphere (LBM) prevents L-dopa induced dyskinesia by inactivation of the DR1/PKA/P-tau pathway in 6-OHDA-lesioned Parkinson's rats

PubMed Central

Xie, Cheng-long; Wang, Wen-Wen; Zhang, Su-fang; Yuan, Ming-Lu; Che, Jun-Yi; Gan, Jing; Song, Lu; Yuan, Wei-En; Liu, Zhen-Guo

2014-01-01

L-3, 4-dihydroxyphenylalanine (L-dopa) is the gold standard for symptomatic treatment of Parkinson's disease (PD), but long-term therapy is associated with the emergence of L-dopa-induced dyskinesia (LID). In the present study, L-dopa and benserazide were loaded by poly (lactic-co-glycolic acid) microspheres (LBM), which can release levodopa and benserazide in a sustained manner in order to continuous stimulate dopaminergic receptors. We investigated the role of striatal DR1/PKA/P-tau signal transduction in the molecular event underlying LID in the 6-OHDA-lesioned rat model of PD. We found that animals rendered dyskinetic by L-dopa treatment, administration of LBM prevented the severity of AIM score, as well as improvement in motor function. Moreover, we also showed L-dopa elicits profound alterations in the activity of three LID molecular markers, namely DR1/PKA/P-tau (ser396). These modifications are totally prevented by LBM treatment, a similar way to achieve continuous dopaminergic delivery (CDD). In conclusion, our experiments provided evidence that intermittent administration of L-dopa, but not continuous delivery, and DR1/PKA/p-tau (ser396) activation played a critical role in the molecular and behavioural induction of LID in 6-OHDA-lesioned rats. In addition, LBM treatment prevented the development of LID by inhibiting the expression of DR1/PKA/p-tau, as well as PPEB mRNA in dyskintic rats. PMID:25511986

Levodopa/benserazide microsphere (LBM) prevents L-dopa induced dyskinesia by inactivation of the DR1/PKA/P-tau pathway in 6-OHDA-lesioned Parkinson's rats.

PubMed

Xie, Cheng-long; Wang, Wen-Wen; Zhang, Su-fang; Yuan, Ming-Lu; Che, Jun-Yi; Gan, Jing; Song, Lu; Yuan, Wei-En; Liu, Zhen-Guo

2014-12-16

L-3, 4-dihydroxyphenylalanine (L-dopa) is the gold standard for symptomatic treatment of Parkinson's disease (PD), but long-term therapy is associated with the emergence of L-dopa-induced dyskinesia (LID). In the present study, L-dopa and benserazide were loaded by poly (lactic-co-glycolic acid) microspheres (LBM), which can release levodopa and benserazide in a sustained manner in order to continuous stimulate dopaminergic receptors. We investigated the role of striatal DR1/PKA/P-tau signal transduction in the molecular event underlying LID in the 6-OHDA-lesioned rat model of PD. We found that animals rendered dyskinetic by L-dopa treatment, administration of LBM prevented the severity of AIM score, as well as improvement in motor function. Moreover, we also showed L-dopa elicits profound alterations in the activity of three LID molecular markers, namely DR1/PKA/P-tau (ser396). These modifications are totally prevented by LBM treatment, a similar way to achieve continuous dopaminergic delivery (CDD). In conclusion, our experiments provided evidence that intermittent administration of L-dopa, but not continuous delivery, and DR1/PKA/p-tau (ser396) activation played a critical role in the molecular and behavioural induction of LID in 6-OHDA-lesioned rats. In addition, LBM treatment prevented the development of LID by inhibiting the expression of DR1/PKA/p-tau, as well as PPEB mRNA in dyskintic rats.

Objective Brow Height Measurements Following Pretrichial Brow Lift and Upper Lid Blepharoplasty

PubMed Central

Martin, Matthew; Shah, Christopher T; Attawala, Payal; Neaman, Keith; Meldrum, Melissa; Hassan, Adam S

2016-01-01

Background: As the ptotic brow drops below the supraorbital rim, it can exacerbate dermatochalasis by pushing the adjacent skin of the upper lid further down. Aim: The purpose of this study was to evaluate the outcomes associated with a combined pretrichial brow lift and upper lid blepharoplasty in patients with dermatochalasis and mild to moderate brow ptosis. Materials and Methods: A retrospective case series of 46 patients with dermatochalasis and mild to moderate brow ptosis treated with a combined, bilateral pretrichial brow lift and upper lid blepharoplasty from January 2008 to December 2011. Main outcome measures included measurements of brow lift at 3 months post-operatively, complications encountered, patient satisfaction and surgeon satisfaction. Results: Outcomes from 46 patients were evaluated. The mean brow lift was 1.85 mm at the lateral canthus, 1.54 mm at the lateral limbus, 1.31 mm at the mid-pupil, and 1.07 mm at the medial limbus. Brow lift at the lateral canthus was significantly more elevated than at the medial limbus (P < 0.001). Minor complications were encountered in seven of 46 patients (15.2%). Mean patient satisfaction score was 3.20 and surgeon satisfaction 3.24 (max = 4, very satisfied). Conclusions: The modified pretrichial brow lift offered effective lateral lift that complements an upper lid blepharoplasty. This technique was met with a high degree of patient and surgeon satisfaction, and had a minimal complication profile. PMID:27398009

Modeling flood reduction effects of low impact development at a watershed scale.

PubMed

Ahiablame, Laurent; Shakya, Ranish

2016-04-15

Low impact development (LID) is a land development approach that seeks to mimic a site's pre-development hydrology. This study is a case study that assessed flood reduction capabilities of large-scale adoption of LID practices in an urban watershed in central Illinois using the Personal Computer Storm Water Management Model (PCSWMM). Two flood metrics based on runoff discharge were developed to determine action flood (43 m(3)/s) and major flood (95 m(3)/s). Four land use scenarios for urban growth were evaluated to determine the impacts of urbanization on runoff and flooding. Flood attenuation effects of porous pavement, rain barrel, and rain garden at various application levels were also evaluated as retrofitting technologies in the study watershed over a period of 30 years. Simulation results indicated that increase in urban land use from 50 to 94% between 1992 and 2030 increased average annual runoff and flood events by more than 30%, suggesting that urbanization without sound management would increase flood risks. The various implementation levels of the three LID practices resulted in 3-47% runoff reduction in the study watershed. Flood flow events that include action floods and major floods were also reduced by 0-40%, indicating that LID practices can be used to mitigate flood risk in urban watersheds. The study provides an insight into flood management with LID practices in existing urban areas. Copyright © 2016 Elsevier Ltd. All rights reserved.

Lines in the spectrum of /sup 6/LiD (3086--5156 A)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, K.C.

1976-01-01

The emission spectra of A/sup 1/..sigma../sup +/--X/sup 1/..sigma../sup +/ bands of /sup 6/LiD were photographed in the 3086 A - 5156 A region with a 3.4 meter Ebert Spectrograph of theoretical resolution of about 0.07 cm/sup -1/. High-purity /sup 6/LiD crystals were obtained from Oak Ridge National Laboratory. The atomic percent of /sup 6/Li in /sup 6/LiD was 95.58 percent. The discharge source is a demountable stainless steel hollow cathode lamp. The lithium deuteride crystals were packed into the cathode. Pressure in the discharge tube was about 10 to 20 torr of D/sub 2/. The discharge was run at aboutmore » 600 volts and 1.25 to 1.75 amperes. Acceptable spectra were obtained with exposure time of 6 hours. A Westinghouse iron hollow cathode was used to produce the iron spectrum for calibration. The plates were measured on the Gaertner photoplate comparator with an encoder system and on-line computer service at Argonne National Laboratory. The measured lines in the spectra of /sup 6/LiD are given in this report (COO-2326-18). Similar spectra for /sup 6/LiH and /sup 7/LiH are given in companion reports (COO-2326-17) and (COO-2326-19), respectively. The relative intensities of the lines are applicable only to short regions and do not extend over the whole spectrum.« less

Segregation of Calcium Isotopes in the Atmospheres of CP Stars as a Consequence of Light-Induced Drift

NASA Astrophysics Data System (ADS)

Parkhomenko, A. I.; Shalagin, A. M.

2018-06-01

A mechanism for the segregation of calcium isotopes in the atmospheres of chemically peculiar (CP) stars due to light-induced drift (LID) of singly charged 48Ca+ ions is discussed. One peculiarity of Ca+ is that an adequate description of the effect of LID requires taking into account several energy levels of Ca+, and thus several pairs of relative differences ( ν i - ν k )/ ν i for the transport frequencies for collisions of levels i and k with neutral atoms (hydrogen, helium). The known real (calculated ab initio) interaction potentials are used to numerically calculate the factors ( ν i - ν k )/ ν i for several states of Ca+ for collisions with H and He atoms. These computations show that, at the temperatures characteristic of the atmospheres of CP stars, T = 6600-12 000 K, fairly high values are obtained for Ca+ ions, ( ν i - ν k )/ ν i ≈ 0.4-0.6. Simple, transparent computations demonstrate that the LID rates of Ca+ ions in the atmospheres of cool CP stars ( T eff = 6600 K) exceed the drift rate due to light pressure by two orders of magnitude. The LID is directed upward in the stellar atmosphere, and the heavy isotope 48Ca is pushed into upper layers of the atmosphere. This can explain the observed predominance of the heavy isotope 48Ca in the upper atmospheric layers of CP stars; according to the radiative-diffusion theory, the action of light pressure alone (in the absence of LID) would lead to sinking of the isotope 48Ca deeper into stellar atmosphere, following the lighter main isotope 40Ca. The 48Ca+ LIDrate decreases and its drift rate due to light pressure increases with growth of the effective temperatures in the atmospheres of CP stars. The manifestations of LID and light pressure are roughly comparable in the atmospheres of CP stars with effective temperatures near T eff = 9500 K.

Long-term preservation of early formed mantle heterogeneity by mobile lid convection: Importance of grainsize evolution

NASA Astrophysics Data System (ADS)

Foley, Bradford J.; Rizo, Hanika

2017-10-01

The style of tectonics on the Hadean and Archean Earth, particularly whether plate tectonics was in operation or not, is debated. One important, albeit indirect, constraint on early Earth tectonics comes from observations of early-formed geochemical heterogeneities: 142Nd and 182W anomalies recorded in Hadean to Phanerozoic rocks from different localities indicate that chemically heterogeneous reservoirs, formed during the first ∼500 Myrs of Earth's history, survived their remixing into the mantle for over 1 Gyrs. Such a long mixing time is difficult to explain because hotter mantle temperatures, expected for the early Earth, act to lower mantle viscosity and increase convective vigor. Previous studies found that mobile lid convection typically erases heterogeneity within ∼100 Myrs under such conditions, leading to the hypothesis that stagnant lid convection on the early Earth was responsible for the observed long mixing times. However, using two-dimensional Cartesian convection models that include grainsize evolution, we find that mobile lid convection can preserve heterogeneity at high mantle temperature conditions for much longer than previously thought, because higher mantle temperatures lead to larger grainsizes in the lithosphere. These larger grainsizes result in stronger plate boundaries that act to slow down surface and interior convective motions, in competition with the direct effect temperature has on mantle viscosity. Our models indicate that mobile lid convection can preserve heterogeneity for ≈0.4-1 Gyrs at early Earth mantle temperatures when the initial heterogeneity has the same viscosity as the background mantle, and ≈1-4 Gyrs when the heterogeneity is ten times more viscous than the background mantle. Thus, stagnant lid convection is not required to explain long-term survival of early formed geochemical heterogeneities, though these heterogeneities having an elevated viscosity compared to the surrounding mantle may be essential for their preservation.

Integrated hydro-environmental impact assessment and alternative selection of low impact development practices in small urban catchments.

PubMed

Yang, Yang; Chui, Ting Fong May

2018-06-20

Attention is increasingly being paid to low impact development (LID) practices in urban stormwater management. Because LID practices offer a wide variety of hydro-environmental benefits, it is often necessary to account for these benefits collectively in cost-benefit analysis and LID alternative selection. The conventional methods of quantifying these benefits, however, can hardly incorporate the preferences of decision makers, and commonly involve tedious parameter estimations. To address these shortcomings, this study adopts a relative performance evaluation method to assess the various hydro-environmental impacts of LID alternatives in small urban catchments. This study considers several categories of hydro-environmental impacts, including water balance impact, surface pollutant load abatement, and combined sewer overflow and flood risk mitigation. Several performance indicators are used for each impact category. The system-wide effectiveness of an LID alternative is then derived by the weighted aggregation of its indicator scores, which are obtained by comparing its performance with that of all of the other alternatives. The hydro-environmental impact of green roofs and bioretention cells of varying areas in New York City, U.S. are investigated in detail. The results suggest that a green roof that covers the whole catchment is as effective as a bioretention cell that covers 3%-5% of the catchment in terms of stormwater management, and that the effectiveness of a bioretention cell doubles when its surface area increases from 2% to 10% of the catchment area. These assessment results are influenced by catchment-specific assessment criteria (e.g., the high flow threshold) and management interests, which suggests that design guidelines for different catchments should be tailored to their natural and drainage characteristics. The framework used in this study allows stakeholders' interests to be reflected in LID alternative selections and the implications of different design guidelines to be thoroughly investigated. Copyright © 2018 Elsevier Ltd. All rights reserved.

Setting appropriate pass or fail cut-off criteria for tests to reflect real life listening difficulties in children with suspected auditory processing disorder.

PubMed

Ahmmed, Ansar U; Ahmmed, Afsara A

2016-05-01

This paper explores the pass or fail cut-off criteria, the number of test fails, and the nature of tests that are most appropriate in predicting listening difficulties (LiD) in children with suspected APD (SusAPD). One hundred and nine English-speaking children (67 males, 42 females) aged between 6 and 11 years with SusAPD were assessed. The Children's Auditory Performance Scale (CHAPS) scores 2 SD below the mean were taken as markers of LiD in different listening conditions. Binary logistic regression analyses were carried out to evaluate the cut-off criterion (2 SD or 1.5 SD or 1 SD below the mean) of failing at least two tests, from the SCAN-C and IMAP test batteries, which significantly predicted LiD. Analyses were also carried out to assess if the group of auditory processing (AP) or cognitive or combination of AP plus cognitive tests were significant in predicting LiD. Receiver Operative Characteristic (ROC) curves were also explored to evaluate how the sensitivity and specificity in confirming LiD varied with the number of test fails. Filtered Words, Competing Words, Competing Sentences, VCV in ICRA noise, Digit Span, Sight Word Reading and the Cued Auditory Attention tests correlated with one or more of the CHAPS domains. Failing at least two of these tests 1.5 SD below the mean significantly predicted (p<.05) CHAPS Ideal scores 2 SD below the mean, and failing at least two of the tests 1 SD below the mean significantly predicted (p<.05) CHAPS Memory and CHAPS Attention scores 2 SD below the mean. The combination of AP plus cognitive tests had significantly higher ability to predict CHAPS Ideal, Memory and Attention scores, compared to the group of AP or cognitive tests separately. ROC curves showed that failing at least two of the tests was associated with the best sensitivity and specificity in predicting LiD. Of the different CHAPS domains only the CHAPS Ideal, Memory and Attention correlated with the APD tests. Failing at least two APD tests from a combination of AP and cognitive tests 1 SD and 1.5 SD below the mean, but not 2 SD, is more appropriate in confirming LiD. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

LDPC decoder with a limited-precision FPGA-based floating-point multiplication coprocessor

NASA Astrophysics Data System (ADS)

Moberly, Raymond; O'Sullivan, Michael; Waheed, Khurram

2007-09-01

Implementing the sum-product algorithm, in an FPGA with an embedded processor, invites us to consider a tradeoff between computational precision and computational speed. The algorithm, known outside of the signal processing community as Pearl's belief propagation, is used for iterative soft-decision decoding of LDPC codes. We determined the feasibility of a coprocessor that will perform product computations. Our FPGA-based coprocessor (design) performs computer algebra with significantly less precision than the standard (e.g. integer, floating-point) operations of general purpose processors. Using synthesis, targeting a 3,168 LUT Xilinx FPGA, we show that key components of a decoder are feasible and that the full single-precision decoder could be constructed using a larger part. Soft-decision decoding by the iterative belief propagation algorithm is impacted both positively and negatively by a reduction in the precision of the computation. Reducing precision reduces the coding gain, but the limited-precision computation can operate faster. A proposed solution offers custom logic to perform computations with less precision, yet uses the floating-point format to interface with the software. Simulation results show the achievable coding gain. Synthesis results help theorize the the full capacity and performance of an FPGA-based coprocessor.

Collision Visualization of a Laser-Scanned Point Cloud of Streets and a Festival Float Model Used for the Revival of a Traditional Procession Route

NASA Astrophysics Data System (ADS)

Li, W.; Shigeta, K.; Hasegawa, K.; Li, L.; Yano, K.; Tanaka, S.

2017-09-01

Recently, laser-scanning technology, especially mobile mapping systems (MMSs), has been applied to measure 3D urban scenes. Thus, it has become possible to simulate a traditional cultural event in a virtual space constructed using measured point clouds. In this paper, we take the festival float procession in the Gion Festival that has a long history in Kyoto City, Japan. The city government plans to revive the original procession route that is narrow and not used at present. For the revival, it is important to know whether a festival float collides with houses, billboards, electric wires or other objects along the original route. Therefore, in this paper, we propose a method for visualizing the collisions of point cloud objects. The advantageous features of our method are (1) a see-through visualization with a correct depth feel that is helpful to robustly determine the collision areas, (2) the ability to visualize areas of high collision risk as well as real collision areas, and (3) the ability to highlight target visualized areas by increasing the point densities there.

The Complex Construction of Professional Identities: Female EFL Educators in Japan Speak Out

ERIC Educational Resources Information Center

Simon-Maeda, Andrea

2004-01-01

This article reports on the life history narratives of nine female EFL teachers working in higher education in Japan. An interpretive qualitative analysis of the stories suggested that gender cannot be viewed as a free-floating attribute of individual subjectivities but rather must be seen as one of many components in an ever-evolving network of…

Notes on the Operations of 21 Army Group. 6 June 1944 - 5 May 1945

DTIC Science & Technology

1945-09-01

contained D. coosidcn~a:P1e n’JDbcr of concreto Cl~rple.cenents, due;-outs etc. All were ’,·?ired and coverc:c1 by extcnsi ve tuneficlds. Coc,st...floating piers and pierheads were of concreto and steel, some 50,000 tons of steel being usod in their construction. Concrete caissons, each some

77 FR 37707 - Draft Environmental Impact Statement on Brooks River Visitor Access for Katmai National Park and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-22

... floating bridge and sites to relocate the existing Naknek Lake barge landing area at the mouth of the... landing site on Naknek Lake. Alternative 3: This alternative evaluates construction of a new bridge and... barge landing site would be located approximately 200 feet south of the mouth of the Brooks River. A new...

Stability and Variability in Young Children's Understanding of Floating and Sinking during One Single-Task Session

ERIC Educational Resources Information Center

Meindertsma, Heidi B.; van Dijk, Marijn W. G.; Steenbeek, Henderien W.; van Geert, Paul L. C.

2014-01-01

Intraindividual variability is a key component in explaining children's development and learning. Studying this type of variability on the micro-timescale can help us understand real-time constructive processes and the subsequent long-term development. The aim of this article is to study the process of children's understanding of…

Survey of Experience Using Reinforced Concrete in Floating Marine Structures.

DTIC Science & Technology

1983-01-01

organizations involved in materials research and testing . The second largest group consists of those involved in design, consulting, and construction...This distribution is consistent with the open literature where the majority of articles are concerned with materials research, testing , and design. Only...example, organizations involved in materials research, design, testing , and certification were visited in the Netherlands, France, Norway, Scotland, and

Performance of a full scale prototype detector at the BR2 reactor for the SoLid experiment

NASA Astrophysics Data System (ADS)

Abreu, Y.; Amhis, Y.; Arnold, L.; Ban, G.; Beaumont, W.; Bongrand, M.; Boursette, D.; Castle, B. C.; Clark, K.; Coupé, B.; Cussans, D.; De Roeck, A.; D'Hondt, J.; Durand, D.; Fallot, M.; Ghys, L.; Giot, L.; Guillon, B.; Ihantola, S.; Janssen, X.; Kalcheva, S.; Kalousis, L. N.; Koonen, E.; Labare, M.; Lehaut, G.; Manzanillas, L.; Mermans, J.; Michiels, I.; Moortgat, C.; Newbold, D.; Park, J.; Pestel, V.; Petridis, K.; Piñera, I.; Pommery, G.; Popescu, L.; Pronost, G.; Rademacker, J.; Ryckbosch, D.; Ryder, N.; Saunders, D.; Schune, M.-H.; Simard, L.; Vacheret, A.; Van Dyck, S.; Van Mulders, P.; van Remortel, N.; Vercaemer, S.; Verstraeten, M.; Weber, A.; Yermia, F.

2018-05-01

The SoLid collaboration has developed a new detector technology to detect electron anti-neutrinos at close proximity to the Belgian BR2 reactor at surface level. A 288 kg prototype detector was deployed in 2015 and collected data during the operational period of the reactor and during reactor shut-down. Dedicated calibration campaigns were also performed with gamma and neutron sources. This paper describes the construction of the prototype detector with a high control on its proton content and the stability of its operation over a period of several months after deployment at the BR2 reactor site. All detector cells provide sufficient light yields to achieve a target energy resolution of better than 20%/√E(MeV). The capability of the detector to track muons is exploited to equalize the light response of a large number of channels to a precision of 3% and to demonstrate the stability of the energy scale over time. Particle identification based on pulse-shape discrimination is demonstrated with calibration sources. Despite a lower neutron detection efficiency due to triggering constraints, the main backgrounds at the reactor site were determined and taken into account in the shielding strategy for the main experiment. The results obtained with this prototype proved essential in the design optimization of the final detector.

Overview of LIDS Docking Seals Development

NASA Technical Reports Server (NTRS)

Dunlap, Pat; Steinetz, Bruce; Daniels, Chris

2008-01-01

NASA is developing a new docking system to support future space exploration missions to low-Earth orbit, the Moon, and Mars. This mechanism, called the Low Impact Docking System (LIDS), is designed to connect pressurized space vehicles and structures including the Crew Exploration Vehicle, International Space Station, and lunar lander. NASA Glenn Research Center (GRC) is playing a key role in developing the main interface seal for this new docking system. These seals will be approximately 147 cm (58 in.) in diameter. GRC is evaluating the performance of candidate seal designs under simulated operating conditions at both sub-scale and full-scale levels. GRC is ultimately responsible for delivering flight hardware seals to NASA Johnson Space Center around 2013 for integration into LIDS flight units.

Subcuticular Suture Technique: Alternative to Frost Suture to Prevent Ectropion After Transcutaneous Incision of Lower Eyelid.

PubMed

Kudva, Adarsh; Kamath, Abhay; Cariappa, K M; Gadicherla, Srikanth; Dhara, B Vasantha

2017-12-01

An ectropion is a complication that can arise from reconstruction in the infraorbital region. Often, this complication occurs despite proper positioning of the lower lid at the time of closure. Various transcutaneous approaches to orbit skeleton have investigated in view of complication arising from them. A subtarsal approach with a postoperative Frost suture gives an advantage to reduce the occurrence of ectropion especially after treatment of orbital floor fractures. This case describes a method of subcuticular suturing technique for subtarsal incision of lower lid which can be used to support the lid during healing period, thus decreasing the rate of ectropion. The technique described here is an alterative method for frost suturing with certain advantages.

Floating into Deep Space

NASA Astrophysics Data System (ADS)

La Frenais, R.; Saraceno, T.; Powell, J.

2014-04-01

Is it possible for spaceflight to become more sustainable? Artist and architect Tomas Saraceno proposes a long-term artscience research project based on his initial work with solar balloons to join with the efforts of engineers such as John Powell, working on the Airship to Orbit experiments, which describe a three stage process of using airships to fly to a large suborbital "Dark Sky Station' then literally floating into orbit with additional electrical and chemical propulsion. (See: http://www.jpaerospace.com) In his artworks Tomás Saraceno proposes cell-like flying cities as possible architectonic living spaces in direct reference to Buckminster Fuller's Cloud Nine (circa 1960). The fantastic architectural utopia Cloud Nine consists of a freely floating sphere measuring one mile in diameter that offers living space to several autonomous communities encompassing thousands of inhabitants each. The notion of the cloud is essential to the artist's work. The cloud as metaphor stands for artistic intention, for the meaning of territory and border in today's (urban) society, and for exploring possibilities for the sustainable development of the human living environment. In Saraceno's work this environment is not limited to the earth, but is explicitly conceived to reach into outer space. (Biomimetic Constructions- On the works of Tomás Saraceno By Katharina Schlüter) Saraceno is also interested in human factors experiments using his existing constructions as analogue environments for living on Mars and is proposing carry out a series of workshops, experiments and solar balloon launces in White Sands desert in early 2016 in collaboration with the curator Dr Rob La Frenais, the Rubin Center at The University of Texas at El Paso and various scientific partners.

Raft and floating radio frequency identification (RFID) antenna systems for detecting and estimating abundance of PIT-tagged fish in rivers

USGS Publications Warehouse

Fetherman, Eric R.; Avila, Brian W.; Winkelman, Dana L.

2016-01-01

Portable radio frequency identification (RFID) PIT tag antenna systems are increasingly being used in studies examining aquatic animal movement, survival, and habitat use, and their design flexibility permits application in a wide variety of settings. We describe the construction, use, and performance of two portable floating RFID PIT tag antenna systems designed to detect fish that were unavailable for recapture using stationary antennas or electrofishing. A raft antenna system was designed to detect and locate PIT-tagged fish in relatively long (i.e., ≥10 km) river reaches, and consisted of two antennas: (1) a horizontal antenna (4 × 1.2 m) installed on the bottom of the raft and used to detect fish in shallower river reaches (<1 m), and (2) a vertical antenna (2.7 × 1.2 m) for detecting fish in deeper pools (≥1 m). Detection distances of the horizontal antenna were between 0.7 and 1.0 m, and detection probability was 0.32 ± 0.02 (mean ± SE) in a field test using rocks marked with 32-mm PIT tags. Detection probability of PIT-tagged fish in the Cache la Poudre River, Colorado, using the raft antenna system, which covered 21% of the wetted area, was 0.14 ± 0.14. A shore-deployed floating antenna (14.6 × 0.6 m), which covered 100% of the wetted area, was designed for use by two operators for detecting and locating PIT-tagged fish in shorter (i.e., <2 km) river reaches. Detection distances of the shore-deployed floating antenna were between 0.7 and 0.8 m, and detection probabilities during field deployment in the St. Vrain River exceeded 0.52. The shore-deployed floating antenna was also used to estimate abundance of PIT-tagged fish. Results suggest that the shore-deployed floating antenna could be used as an alternative to estimating abundance using traditional sampling methods such as electrofishing.

Design of a toroidal device with a high temperature superconductor coil for non-neutral plasma trap

NASA Astrophysics Data System (ADS)

Ogawa, Yuichi; Morikawa, Junji; Nihei, Hitoshi; Ozawa, Daisaku; Yoshida, Zensho; Mito, Toshiyuki; Yanagi, Nagato; Iwakuma, Masataka

2002-01-01

The non-neutral plasma confinement device with a floating internal coil is under construction, where the high temperature superconductor (HTS) Ag-sheathed BSCCO-2223 is employed as the floating coil. We have two topics with this device: one is a trap of a non-neutral plasma consisting of one species, and another is an exploration of a high beta plasma based on two-fluid MHD relaxation theory. In the latter case the plasma should be non-neutralized in order to drive the plasma flow in the toroidal direction. The expected plasma parameters are discussed. Key elements of engineering issues have already developed. In addition, we have fabricated a small HTS coil and succeeded in levitating it within an accuracy of 25˜30 μm for 4 min or more.

From 16-bit to high-accuracy IDCT approximation: fruits of single architecture affliation

NASA Astrophysics Data System (ADS)

Liu, Lijie; Tran, Trac D.; Topiwala, Pankaj

2007-09-01

In this paper, we demonstrate an effective unified framework for high-accuracy approximation of the irrational co-effcient floating-point IDCT by a single integer-coeffcient fixed-point architecture. Our framework is based on a modified version of the Loeffler's sparse DCT factorization, and the IDCT architecture is constructed via a cascade of dyadic lifting steps and butterflies. We illustrate that simply varying the accuracy of the approximating parameters yields a large family of standard-compliant IDCTs, from rare 16-bit approximations catering to portable computing to ultra-high-accuracy 32-bit versions that virtually eliminate any drifting effect when pairing with the 64-bit floating-point IDCT at the encoder. Drifting performances of the proposed IDCTs along with existing popular IDCT algorithms in H.263+, MPEG-2 and MPEG-4 are also demonstrated.

Thailand national programme of the Earth Resources Technology Satellite

NASA Technical Reports Server (NTRS)

Cheosakul, P. (Principal Investigator)

1973-01-01

The author has identified the following significant results. ERTS-1 data has been used to delineate floating rice regions with a clear distinction between irrigated and nonirrigated areas and recognition of orchard and horitcultural crops. Alluvial fans marking the ancient river outlets in the northwestern portion of the Central Plain of Thailand and the shape and size of the flood plains in the central region have been identified and outlined. A new forestry map was constructed using band 5 and band 7 imagery combined with ground observations. A geologic map of Thailand has been constructed from ERTS imagery.

Lack of LTP-like plasticity in primary motor cortex in Parkinson's disease.

PubMed

Suppa, A; Marsili, L; Belvisi, D; Conte, A; Iezzi, E; Modugno, N; Fabbrini, G; Berardelli, A

2011-02-01

In this study in patients with Parkinson's disease (PD), off and on dopaminergic therapy, with and without L-dopa-induced dyskinesias (LIDs), we tested intermittent theta-burst stimulation (iTBS), a technique currently used for non-invasively inducing long-term potentiation (LTP)-like plasticity in primary motor cortex (M1). The study group comprised 20 PD patients on and off dopaminergic therapy (11 patients without and 9 patients with LIDs), and 14 age-matched healthy subjects. Patients had mild-to-moderate PD, and no additional neuropsychiatric disorders. We clinically evaluated patients using the Unified Parkinson's Disease Rating Scale (UPDRS) and the Unified Dyskinesia Rating Scale (UDysRS). The left M1 was conditioned with iTBS at 80% active motor threshold intensity. Twenty motor evoked potentials (MEPs) were recorded from right first interosseous muscle before and at 5, 15 and 30 min after iTBS. Between-group analysis of variance (ANOVA) testing healthy subjects versus patients with and without LIDs, on and off therapy showed a significant interaction between factors "Group" and "Time". After iTBS, MEP amplitudes in healthy subjects increased significantly at 5, 15 and 30 min (p<0.01 at all time-points) but in PD patients with and without LIDs, on and off therapy, remained unchanged. In PD patients with and without LIDs, on and off therapy iTBS fails to increase MEP responses. This finding suggests lack of iTBS-induced LTP-like plasticity in M1 in PD regardless of patients' clinical features. Copyright © 2010 Elsevier Inc. All rights reserved.

Urban recharge beneath low impact development and effects of climate variability and change

NASA Astrophysics Data System (ADS)

Newcomer, Michelle E.; Gurdak, Jason J.; Sklar, Leonard S.; Nanus, Leora

2014-02-01

low impact development (LID) planning and best management practices (BMPs) effects on recharge is important because of the increasing use of LID BMPs to reduce storm water runoff and improve surface-water quality. LID BMPs are microscale, decentralized management techniques such as vegetated systems, pervious pavement, and infiltration trenches to capture, reduce, filter, and slow storm water runoff. Some BMPs may enhance recharge, which has often been considered a secondary management benefit. Here we report results of a field and HYDRUS-2D modeling study in San Francisco, California, USA to quantify urban recharge rates, volumes, and efficiency beneath a LID BMP infiltration trench and irrigated lawn considering historical El Niño/Southern Oscillation (ENSO) variability and future climate change using simulated precipitation from the Geophysical Fluid Dynamic Laboratory (GFDL) A1F1 climate scenario. We find that in situ and modeling methods are complementary, particularly for simulating historical and future recharge scenarios, and the in situ data are critical for accurately estimating recharge under current conditions. Observed (2011-2012) and future (2099-2100) recharge rates beneath the infiltration trench (1750-3710 mm yr-1) were an order of magnitude greater than beneath the irrigated lawn (130-730 mm yr-1). Beneath the infiltration trench, recharge rates ranged from 1390 to 5840 mm yr-1 and averaged 3410 mm yr-1 for El Niño years (1954-2012) and from 1540 to 3330 mm yr-1 and averaged 2430 mm yr-1 for La Niña years. We demonstrate a clear benefit for recharge and local groundwater resources using LID BMPs.

The effects of internal heating and large scale climate variations on tectonic bi-stability in terrestrial planets

NASA Astrophysics Data System (ADS)

Weller, M. B.; Lenardic, A.; O'Neill, C.

2015-06-01

We use 3D mantle convection and planetary tectonics models to explore the links between tectonic regimes and the level of internal heating within the mantle of a planet (a proxy for thermal age), planetary surface temperature, and lithosphere strength. At both high and low values of internal heating, for moderate to high lithospheric yield strength, hot and cold stagnant-lid (single plate planet) states prevail. For intermediate values of internal heating, multiple stable tectonic states can exist. In these regions of parameter space, the specific evolutionary path of the system has a dominant role in determining its tectonic state. For low to moderate lithospheric yield strength, mobile-lid behavior (a plate tectonic-like mode of convection) is attainable for high degrees of internal heating (i.e., early in a planet's thermal evolution). However, this state is sensitive to climate driven changes in surface temperatures. Relatively small increases in surface temperature can be sufficient to usher in a transition from a mobile- to a stagnant-lid regime. Once a stagnant-lid mode is initiated, a return to mobile-lid is not attainable by a reduction of surface temperatures alone. For lower levels of internal heating, the tectonic regime becomes less sensitive to surface temperature changes. Collectively our results indicate that terrestrial planets can alternate between multiple tectonic states over giga-year timescales. Within parameter space regions that allow for bi-stable behavior, any model-based prediction as to the current mode of tectonics is inherently non-unique in the absence of constraints on the geologic and climatic histories of a planet.

The lid of the container for the Mobile Base System, part of the Canadian arm, is prepared for remov

NASA Technical Reports Server (NTRS)

2000-01-01

Inside the Space Station Processing Facility, workers prepare to remove the lid of a container holding the Mobile Base System (MBS). The MBS is part of the Canadian Space Agency's Space Station Remote Manipulator System (SSRMS), which is part of the payload on mission STS-100 to the International Space Station.

40 CFR 63.304 - Standards for compliance date extension.

Code of Federal Regulations, 2011 CFR

2011-07-01

...) 0.83 percent leaking topside port lids, as determined by the procedures in § 63.309(d)(1); (iii) 4.2... this section, as determined by the procedures in § 63.309(d)(1); (ii) 0.4 percent leaking topside port...) 0.4 percent leaking topside port lids, as determined by the procedures in § 63.309(d)(1); (iii) 2.5...

40 CFR 63.304 - Standards for compliance date extension.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) 0.83 percent leaking topside port lids, as determined by the procedures in § 63.309(d)(1); (iii) 4.2... this section, as determined by the procedures in § 63.309(d)(1); (ii) 0.4 percent leaking topside port...) 0.4 percent leaking topside port lids, as determined by the procedures in § 63.309(d)(1); (iii) 2.5...

Predictors of trait dissociation and peritraumatic dissociation induced via cold pressor.

PubMed

Gómez-Pérez, Lydia; López-Martínez, Alicia Eva; Asmundson, Gordon John Glenn

2013-11-30

Understanding which factors predict individual dissociative response during stressful situations is important to clarify the nature of dissociation and the mechanisms associated to its use as a coping strategy. The present study examined (1) whether experiential avoidance (EA), anxiety sensitivity (AS), depressive symptoms, and state anxiety concurrently predicted trait dissociation (TD)-absorption, amnesia, depersonalization, and total TD scores-and laboratory induced dissociation (LID); and (2) whether TD and catastrophizing predicted LID. We also examined whether catastrophizing mediated the relationships between both AS and depressive symptoms and LID. A total of 101 female undergraduate students participated in a cold pressor task, which significantly induced dissociation. Results of hierarchical regression analyses showed that AS at Time 1 (9 months before the experimental session), as well as depressive symptoms and catastrophizing at the time of the experiment (Time 2), predicted LID at Time 2. Depressive symptoms at Time 2 predicted total TD, absorption, and amnesia scores. AS at Time 1 and depressive symptoms at Time 2 predicted depersonalization. AS, depressive symptoms, and catastrophizing seem to facilitate the use of dissociative strategies by healthy individuals, even in response to non-traumatic but discomforting stress. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Integrated high pressure manifold for thermoplastic microfluidic devices

NASA Astrophysics Data System (ADS)

Aghvami, S. Ali; Fraden, Seth

2017-11-01

We introduce an integrated tubing manifold for thermoplastic microfluidic chips that tolerates high pressure. In contrast to easy tubing in PDMS microfluidic devices, tube connection has been challenging for plastic microfluidics. Our integrated manifold connection tolerates 360 psi while conventional PDMS connections fail at 50 psi. Important design considerations are incorporation of a quick-connect, leak-free and high-pressure manifold for the inlets and outlets on the lid and registration marks that allow the precise alignment of the inlets and outlets. In our method, devices are comprised of two molded pieces joined together to create a sealed device. The first piece contains the microfluidic features and the second contains the inlet and outlet manifold, a frame for rigidity and a viewing window. The mold for the lid with integrated manifold is CNC milled from aluminium. A cone shape PDMS component which acts as an O-ring, seals the connection between molded manifold and tubing. The lid piece with integrated inlet and outlets will be a standard piece and can be used for different chips and designs. Sealing the thermoplastic device is accomplished by timed immersion of the lid in a mixture of volatile and non-volatile solvents followed by application of heat and pressure.

Synaptic plasticity and levodopa-induced dyskinesia: electrophysiological and structural abnormalities.

PubMed

Picconi, Barbara; De Leonibus, Elvira; Calabresi, Paolo

2018-02-28

Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive degeneration of dopaminergic neurons located in the midbrain. The gold-standard therapy for PD is the restoration of dopamine (DA) levels through the chronic administration of the DA precursor levodopa (L-DOPA). Although levodopa therapy is the main therapeutic approach for PD, its use is limited by the development of very disabling dyskinetic movements, mainly due to the fluctuation of DA cerebral content. Experimental animal models of PD identified in DA D1/ERK-signaling pathway aberrant activation, occurring in striatal projection neurons, coupled with structural spines abnormalities, the molecular and neuronal basis of L-DOPA-induced dyskinesia (LIDs) occurrence. Different electrophysiological approaches allowed the identification of  the alteration of homeostatic structural and synaptic changes, the neuronal bases of LIDs either in vivo in parkinsonian patients or in vitro in experimental animals. Here, we report the most recent studies showing electrophysiological and morphological evidence of aberrant synaptic plasticity in parkinsonian patients during LIDs in different basal ganglia nuclei and also in cortical transmission, accounting for the complexity of the synaptic changes during dyskinesias. All together, these studies suggest that LIDs are associated with a loss of homeostatic synaptic mechanisms.

Early Earth plume-lid tectonics: A high-resolution 3D numerical modelling approach

NASA Astrophysics Data System (ADS)

Fischer, R.; Gerya, T.

2016-10-01

Geological-geochemical evidence point towards higher mantle potential temperature and a different type of tectonics (global plume-lid tectonics) in the early Earth (>3.2 Ga) compared to the present day (global plate tectonics). In order to investigate tectono-magmatic processes associated with plume-lid tectonics and crustal growth under hotter mantle temperature conditions, we conduct a series of 3D high-resolution magmatic-thermomechanical models with the finite-difference code I3ELVIS. No external plate tectonic forces are applied to isolate 3D effects of various plume-lithosphere and crust-mantle interactions. Results of the numerical experiments show two distinct phases in coupled crust-mantle evolution: (1) a longer (80-100 Myr) and relatively quiet 'growth phase' which is marked by growth of crust and lithosphere, followed by (2) a short (∼20 Myr) and catastrophic 'removal phase', where unstable parts of the crust and mantle lithosphere are removed by eclogitic dripping and later delamination. This modelling suggests that the early Earth plume-lid tectonic regime followed a pattern of episodic growth and removal also called episodic overturn with a periodicity of ∼100 Myr.

Parity Violation in DIS region with SoLID at the upgraded 12 GeV JLab

NASA Astrophysics Data System (ADS)

Tian, Ye; SoLID Collaboration

2017-09-01

In this talk, an overview of PVDIS future experiment by using a Solenoidal Large Intensity Device (SoLID) at Jefferson Lab (JLab) Hall A with the 12 GeV upgrade, along with a brief description of the proposed SoLID spectrometer is discussed. We will obtain data with high statistic and large kinematic coverage for Bjorken 0.3 < x < 0.7 and in the momentum transfer Q2 range 2 - 10 GeV2 by a polarized electron beam scattering on unpolarized deuteron and proton targets. A measurement of PVDIS in deuteron aims to extract fundamental coupling constants C1 q ,C2 q as well as the weak mixing angle sin2θw with a high precision. This measurement can also access QCD physics of searching for charge asymmetry violation in PDF's and higher-twist effects with quark-quark correlations. In addition, the proton target experiment can be a powerful probe of the d / u ratio at high x without any nuclear correction. The designed SoLID spectrometer with its unique feature of high luminosity and large acceptance provides an opportunity to probe physics beyond the Standard Model.

From Rain Tanks to Catchments: Use of Low-Impact Development To Address Hydrologic Symptoms of the Urban Stream Syndrome.

PubMed

Askarizadeh, Asal; Rippy, Megan A; Fletcher, Tim D; Feldman, David L; Peng, Jian; Bowler, Peter; Mehring, Andrew S; Winfrey, Brandon K; Vrugt, Jasper A; AghaKouchak, Amir; Jiang, Sunny C; Sanders, Brett F; Levin, Lisa A; Taylor, Scott; Grant, Stanley B

2015-10-06

Catchment urbanization perturbs the water and sediment budgets of streams, degrades stream health and function, and causes a constellation of flow, water quality, and ecological symptoms collectively known as the urban stream syndrome. Low-impact development (LID) technologies address the hydrologic symptoms of the urban stream syndrome by mimicking natural flow paths and restoring a natural water balance. Over annual time scales, the volumes of stormwater that should be infiltrated and harvested can be estimated from a catchment-scale water-balance given local climate conditions and preurban land cover. For all but the wettest regions of the world, a much larger volume of stormwater runoff should be harvested than infiltrated to maintain stream hydrology in a preurban state. Efforts to prevent or reverse hydrologic symptoms associated with the urban stream syndrome will therefore require: (1) selecting the right mix of LID technologies that provide regionally tailored ratios of stormwater harvesting and infiltration; (2) integrating these LID technologies into next-generation drainage systems; (3) maximizing potential cobenefits including water supply augmentation, flood protection, improved water quality, and urban amenities; and (4) long-term hydrologic monitoring to evaluate the efficacy of LID interventions.

Thermal Interface Materials Selection and Application Guidelines: In Perspective of Xilinx Virtex-5QV Thermal Management

NASA Technical Reports Server (NTRS)

Suh, Jong-ook; Dillon, R. Peter; Tseng, Stephen

2015-01-01

The heat from high-power microdevices for space, such as Xilinx Virtex 4 and 5 (V4 and V5), has to be removed mainly through conduction in the space vacuum environment. The class-Y type packages are designed to remove the heat from the top of the package, and the most effective method to remove heat from the class-Y type packages is to attach a heat transfer device on the lid of the package and to transfer the heat to frame or chassis. When a heat transfer device is attached to the package lid, the surfaces roughness of the package lid and the heat transfer device reduces the effective contact area between the two. The reduced contact area results in increased thermal contact resistance, and a thermal interface material is required to reduce the thermal contact resistance by filling in the gap between the surfaces of the package lid and the heat transfer device. The current report describes JPL's FY14 NEPP task study on property requirements of TIM and impact of TIM properties on the packaging reliability. The current task also developed appratuses to investigate the performances of TIMs in the actual mission environment.

Identifying strategic sites for Green-Infrastructures (GI) to manage stormwater in a miscellaneous use urban African watershed

NASA Astrophysics Data System (ADS)

Selker, J. S.; Kahsai, S. K.

2017-12-01

Green Infrastructure (GI) or Low impact development (LID), is a land use planning and design approach with the objective of mitigating land development impacts to the environment, and is ever more looked to as a way to lessen runoff and pollutant loading to receiving water bodies. Broad-scale approaches for siting GI/LID have been developed for agricultural watersheds, but are rare for urban watersheds, largely due to greater land use complexity. And it is even more challenging when it comes to Urban Africa due to the combination of poor data quality, rapid and unplanned development, and civic institutions unable to reliably carry out regular maintenance. We present a spacio-temporal simulation-based approach to identify an optimal prioritization of sites for GI/LID based on DEM, land use and land cover. Optimization used is a multi-objective optimization tool along with an urban storm water management model (SWMM) to identify the most cost-effective combination of LID/GI. This was applied to an urban watershed in NW Kampala, Lubigi Catchment (notorious for being heavily flooded every year), with a miscellaneous use watershed in Uganda, as a case-study to demonstrate the approach.

Increased putamen hypercapnic vasoreactivity in levodopa-induced dyskinesia.

PubMed

Jourdain, Vincent A; Schindlbeck, Katharina A; Tang, Chris C; Niethammer, Martin; Choi, Yoon Young; Markowitz, Daniel; Nazem, Amir; Nardi, Dominic; Carras, Nicholas; Feigin, Andrew; Ma, Yilong; Peng, Shichun; Dhawan, Vijay; Eidelberg, David

2017-10-19

In a rodent model of Parkinson's disease (PD), levodopa-induced involuntary movements have been linked to striatal angiogenesis - a process that is difficult to document in living human subjects. Angiogenesis can be accompanied by localized increases in cerebral blood flow (CBF) responses to hypercapnia. We therefore explored the possibility that, in the absence of levodopa, local hypercapnic CBF responses are abnormally increased in PD patients with levodopa-induced dyskinesias (LID) but not in their nondyskinetic (NLID) counterparts. We used H215O PET to scan 24 unmedicated PD subjects (12 LID and 12 NLID) and 12 matched healthy subjects in the rest state under normocapnic and hypercapnic conditions. Hypercapnic CBF responses were compared to corresponding levodopa responses from the same subjects. Group differences in hypercapnic vasoreactivity were significant only in the posterior putamen, with greater CBF responses in LID subjects compared with the other subjects. Hypercapnic and levodopa-mediated CBF responses measured in this region exhibited distinct associations with disease severity: the former correlated with off-state motor disability ratings but not symptom duration, whereas the latter correlated with symptom duration but not motor disability. These are the first in vivo human findings linking LID to microvascular changes in the basal ganglia.

Surgical Correction of Hallermann-Streiff Syndrome: A Case Report of Esotropia, Entropion, and Blepharoptosis

PubMed Central

Cho, Won-Kyung; Park, Joo Wan

2011-01-01

We report a case of surgical treatment for Hallermann-Streiff syndrome in a patient with ocular manifestations of esotropia, entropion, and blepharoptosis. A 54-year-old man visited Yeouido St. Mary's Hospital complaining of ocular discomfort due to cilia touching the corneas of both eyes for several years. He had a bird-like face, pinched nose, hypotrichosis of the scalp, mandibular hypoplasia with forward displacement of the temporomandibular joints, a small mouth, and proportional short stature. His ophthalmic features included sparse eyelashes and eyebrows, microphthalmia, nystagmus, lower lid entropion in the right eye, and upper lid entropion with blepharoptosis in both eyes. There was esodeviation of the eyeball of more than 100 prism diopters at near and distance, and there were limitations in ocular movement on lateral gaze. The capsulopalpebral fascia was repaired to treat the right lower lid entropion, but an additional Quickert suture was required to prevent recurrence. Blepharoplasty and levator palpebrae repair were performed for blepharoptosis and dermatochalasis. Three months after lid surgery, the right medial rectus muscle was recessed 7.5 mm, the left medial rectus was recessed 7.25 mm, and the left lateral rectus muscle was resected 8.0 mm. PMID:21461230

Sticky eyelid syndrome.

PubMed

Kortvelesy, J Scott; Buerger, George F

2004-11-01

To report on patients seen with an unusual condition affecting the eyelids. The syndrome manifests as a temporary adhesion which forms between the upper and lower eyelid associated with laxity of the lower lid retractors. This results in a peculiar closure of the lids. Retrospective case reports. Charts of affected patients were reviewed for their clinical histories, examination findings, external photographs, and the results of treatment. Ten consecutive patients with the associated findings were reviewed. All cases were unilateral. Seven patients were Asian and three were Caucasian. Nine patients were symptomatic; of these, all were treated conservatively except for one who requested surgery. Two cases are described and photographs are shown. Lower eyelid retractor laxity combined with a temporary adhesion between the upper and lower lid results in the clinical findings of Sticky Eyelid Syndrome.

Comparison of internal wave properties calculated by Boussinesq equations with/without rigid-lid assumption

NASA Astrophysics Data System (ADS)

Liu, C. M.

2017-12-01

Wave properties predicted by the rigid-lid and the free-surface Boussinesq equations for a two-fluid system are theoretically calculated and compared in this study. Boussinesq model is generally applied to numerically simulate surface waves in coastal regions to provide credible information for disaster prevention and breaker design. As for internal waves, Liu et al. (2008) and Liu (2016) respectively derived a free-surface model and a rigid-lid Boussinesq models for a two-fluid system. The former and the latter models respectively contain four and three key variables which may result in different results and efficiency while simulating. Therefore, present study shows the results theoretically measured by these two models to provide more detailed observation and useful information for motions of internal waves.

The Floating Potential Probe (FPP) taken during the third EVA of STS-97

NASA Image and Video Library

2000-12-07

STS097-376-029 (7 December 2000) --- Space walking Endeavour astronauts topped off their scheduled space walk activities with an image of an evergreen tree placed atop the P6 solar array structure, the highest point in their construction project. They then took this photo of the "tree" before returning to the shirt-sleeve environment of the Space Shuttle Endeavour.

The political use and abuse of the "pedophile".

PubMed

Hunter, James

2008-01-01

The cognitive/affective construct designated by the term pedophile is delineated on the basis of how he is presented in the popular media. His salient characteristics are listed and then examined in the light of scientific and historical data. The pedophile is discovered to be a social construct that floats in the thin air of fantasy. Since the truth-value of the construct pedophile approaches zero, we are confronted with the question of why he continues to be such a central and emotionally fraught aspect of American culture. The answer to this question is found in his political usefulness. Specifically, the religious right uses him to further its agenda of sexual repression, and the political right uses him to dismantle the machinery of a free society.

Safety Analysis of Dual Purpose Metal Cask Subjected to Impulsive Loads due to Aircraft Engine Crash

NASA Astrophysics Data System (ADS)

Shirai, Koji; Namba, Kosuke; Saegusa, Toshiari

In Japan, the first Interim Storage Facility of spent nuclear fuel away from reactor site is being planned to start its commercial operation around 2010, in use of dual-purpose metal cask in the northern part of Main Japan Island. Business License Examination for safety design approval has started since March, 2007. To demonstrate the more scientific and rational performance of safety regulation activities on each phase for the first license procedure, CREPEI has executed demonstration tests with full scale casks, such as drop tests onto real targets without impact limiters(1) and seismic tests subjected to strong earthquake motions(2). Moreover, it is important to develop the knowledge for the inherent security of metal casks under extreme mechanical-impact conditions, especially for increasing interest since the terrorist attacks from 11th September 2001(3)-(6). This paper presents dynamic mechanical behavior of the metal cask lid closure system caused by direct aircraft engine crash and describes calculated results (especially, leak tightness based on relative dynamic displacements between metallic seals). Firstly, the local penetration damage of the interim storage facility building by a big passenger aircraft engine crash (diameter 2.7m, length 4.3m, weight 4.4ton, impact velocity 90m/s) has been examined. The reduced velocity is calculated by the local damage formula for concrete structure with its thickness of 70cm. The load vs. time function for this reduced velocity (60m/s) is estimated by the impact analysis using Finite Element code LS-DYNA with the full scale engine model onto a hypothetically rigid target. Secondly, as the most critical scenarios for the metal cask, two impact scenarios (horizontal impact hitting the cask and vertical impact onto the lid metallic seal system) are chosen. To consider the geometry of all bolts for two lids, the gasket reaction forces and the inner pressure of the cask cavity, the detailed three dimensional FEM models are developed and calculated. Main criteria for estimating the maximum leakage rate for the lid metallic seal system are no loss of the pre-stress of the lid bolts, no appearance of the plastic region between the metal seal flanges, and no large relative deformation of the lid seals. Finally, in both cases, the low leakage rate for the metal cask lid closure system under the impulsive loads due to aircraft engine crash will be proved thoroughly.

Preliminary results of the on-demand vortex-generator experiments

NASA Technical Reports Server (NTRS)

Saddoughi, Seyed G.

1995-01-01

This is a report on the continuation of our experimental investigations (Saddoughi 1994) of 'on-demand' vortex generators. Conventional vortex generators as found on aircraft wings are mainly for suppression of separation during the off-design conditions. In cruise they perform no useful function and exert a significant drag penalty. Therefore, replacement of fixed rectangular or delta-wing generators by devices that could be activated when needed would be of interest. Also in our previous report, we described one example of an 'on-demand' device, which was developed by Jacobson & Reynolds (1995) at Stanford University, suitable for manufacture by micro-electro-mechanical technology. This device consists of a surface cavity elongated in the stream direction and covered with a lid cantilevered at the upstream end. The lid, which is a metal sheet with a sheet of piezoelectric ceramic bonded to it, lies flush with the boundary. On application of a voltage the ceramic expands or contracts; however, adequate amplitude can be obtained only by running at the cantilever resonance frequency and applying amplitude modulation: for 2.5 mm x 20 mm cantilevered lids, they obtained maximum tip displacements of the order of 100 pm. Thus fluid is expelled from the cavity through the gap around the lid on the downstroke. They used an asymmetrical gap configuration and found that periodic emerging jets on the narrow side induced periodic longitudinal vorticity into the boundary layer. Their device was used to modify the inner layer of the boundary layer for skin-friction reduction. The same method could be implemented for the replacement of the conventional vortex generators; however, to promote mixing and suppress separation we needed to deposit longitudinal vortices into the outer layer of the boundary layer, which required a larger vortex generator than the device built by Jacobson & Reynolds. Our vortex generator was built with a mechanically-driven cantilevered lid with an adjustable frequency. The device was made about ten times the size of Jacobson & Reynolds', the shape or size of the cavity and lid (28 mm x 250 mm) could be easily changed. The cavity depth, the cantilever-tip displacement, and the maximum lid frequency were 20 mm, 10 mm, and 60 Hz respectively. Our vortex generator was mounted on a turntable so that its yaw angle could be changed. Finally, tests over a range of ratios of vortex generator size to boundary-layer thickness could be carried out simply by changing the streamwise location of the device.

Assessing cost-effectiveness of specific LID practice designs in response to large storm events

NASA Astrophysics Data System (ADS)

Chui, Ting Fong May; Liu, Xin; Zhan, Wenting

2016-02-01

Low impact development (LID) practices have become more important in urban stormwater management worldwide. However, most research on design optimization focuses on relatively large scale, and there is very limited information or guideline regarding individual LID practice designs (i.e., optimal depth, width and length). The objective of this study is to identify the optimal design by assessing the hydrological performance and the cost-effectiveness of different designs of LID practices at a household or business scale, and to analyze the sensitivity of the hydrological performance and the cost of the optimal design to different model and design parameters. First, EPA SWMM, automatically controlled by MATLAB, is used to obtain the peak runoff of different designs of three specific LID practices (i.e., green roof, bioretention and porous pavement) under different design storms (i.e., 2 yr and 50 yr design storms of Hong Kong, China and Seattle, U.S.). Then, life cycle cost is estimated for the different designs, and the optimal design, defined as the design with the lowest cost and at least 20% peak runoff reduction, is identified. Finally, sensitivity of the optimal design to the different design parameters is examined. The optimal design of green roof tends to be larger in area but thinner, while the optimal designs of bioretention and porous pavement tend to be smaller in area. To handle larger storms, however, it is more effective to increase the green roof depth, and to increase the area of the bioretention and porous pavement. Porous pavement is the most cost-effective for peak flow reduction, followed by bioretention and then green roof. The cost-effectiveness, measured as the peak runoff reduction/thousand Dollars of LID practices in Hong Kong (e.g., 0.02 L/103 US s, 0.15 L/103 US s and 0.93 L/103 US s for green roof, bioretention and porous pavement for 2 yr storm) is lower than that in Seattle (e.g., 0.03 L/103 US s, 0.29 L/103 US s and 1.58 L/103 US s for green roof, bioretention and porous pavement for 2 yr storm). The optimal designs are influenced by the model and design parameters (i.e., initial saturation, hydraulic conductivity and berm height). However, it overall does not affect the main trends and key insights derived, and the results are therefore generic and relevant to the household/business-scale optimal design of LID practices worldwide.

Influence of Intrusive vs. Extrusive Magmatism on Venus' Tectonics and long-term Mantle Evolution: 2D and 3D Simulations

NASA Astrophysics Data System (ADS)

Tackley, Paul

2014-05-01

Here we extend the models of [1]. Numerical convection models of the thermochemical evolution of Venus are compared to present-day topography and geoid, recent resurfacing history and surface deformation. The models include melting, magmatism, decaying heat-producing elements, core cooling, realistic temperature-dependent viscosity and either stagnant lid or episodic lithospheric overturn. In [1] it was found that in stagnant lid convection the dominant mode of heat loss is magmatic heat pipe, which requires massive magmatism and produces very thick, cold crust, inconsistent with observations. Partitioning of heat-producing elements into the crust helps but does not help enough. Episodic lid overturn interspersed by periods of quiescence effectively loses Venus's heat while giving lower rates of volcanism and a thinner crust. Calculations predict 5-8 overturn events over Venus's history, each lasting ˜150 Myr, initiating in one place and then spreading globally. During quiescent periods convection keeps the lithosphere thin. Magmatism keeps the mantle temperature constant over Venus's history. Crustal recycling occurs by entrainment in stagnant lid convection, and by lid overturn in episodic mode. Venus-like amplitudes of topography and geoid can be produced in either stagnant or episodic modes, with a viscosity profile that is Earth-like but shifted to higher values. The basalt density inversion below the olivine-perovskite transition causes compositional stratification around 730 km; breakdown of this layering increases episodicity but far less than episodic lid overturn. The classical stagnant lid mode with interior temperature approximately a rheological temperature scale lower than T_CMB is not reached because mantle temperature is controlled by magmatism while the core cools slowly from a superheated start. Core heat flow decreases with time, possibly shutting off the dynamo, particularly in episodic cases. Here we extend [1] by considering intrusive magmatism as an alternative to the purely extrusive magmatism assumed in [1]. Intrusive magmatism warms and weakens the crust, resulting in substantial surface deformation and a thinner crust. This is further enhanced by using a basaltic rheology for the crust instead of assuming the same rheological parameters as for the mantle. Here we quantitatively analyse the resulting surface deformation and other signatures, and compare to observations in order to constrain the likely ratio of intrusive to extrusive magmatism. [1] Armann, M., and P. J. Tackley (2012), Simulating the thermochemical magmatic and tectonic evo- lution of Venus's mantle and lithosphere: Two-dimensional models, J. Geophys. Res., 117, E12003, doi:10.1029/2012JE004231.

Determination of the State of Strain of Large Floating Covers Using Unmanned Aerial Vehicle (UAV) Aided Photogrammetry

PubMed Central

Ong, Wern Hann; Chiu, Wing Kong; Kuen, Thomas; Kodikara, Jayantha

2017-01-01

Floating covers used in waste water treatment plants are one of the many structures formed with membrane materials. These structures are usually large and can spread over an area measuring 470 m × 170 m. The aim of this paper is to describe recent work to develop an innovative and effective approach for structural health monitoring (SHM) of such large membrane-like infrastructure. This paper will propose a potentially cost-effective non-contact approach for full-field strain and stress mapping using an unmanned aerial vehicle (UAV) mounted with a digital camera and a global positioning system (GPS) tracker. The aim is to use the images acquired by the UAV to define the geometry of the floating cover using photogrammetry. In this manner, any changes in the geometry of the floating cover due to forces acting beneath resulting from its deployment and usage can be determined. The time-scale for these changes is in terms of weeks and months. The change in the geometry can be implemented as input conditions to a finite element model (FEM) for stress prediction. This will facilitate the determination of the state of distress of the floating cover. This paper investigates the possibility of using data recorded from a UAV to predict the strain level and assess the health of such structures. An investigation was first conducted on a laboratory sized membrane structure instrumented with strain gauges for comparison against strains, which were computed from 3D scans of the membrane geometry. Upon validating the technique in the laboratory, it was applied to a more realistic scenario: an outdoor test membrane structure and capable UAV were constructed to see if the shape of the membrane could be computed. The membrane displacements were then used to calculate the membrane stress and strain, state demonstrating a new way to perform structural health monitoring on membrane structures. PMID:28788081

Determination of the State of Strain of Large Floating Covers Using Unmanned Aerial Vehicle (UAV) Aided Photogrammetry.

PubMed

Ong, Wern Hann; Chiu, Wing Kong; Kuen, Thomas; Kodikara, Jayantha

2017-07-28

Floating covers used in waste water treatment plants are one of the many structures formed with membrane materials. These structures are usually large and can spread over an area measuring 470 m × 170 m. The aim of this paper is to describe recent work to develop an innovative and effective approach for structural health monitoring (SHM) of such large membrane-like infrastructure. This paper will propose a potentially cost-effective non-contact approach for full-field strain and stress mapping using an unmanned aerial vehicle (UAV) mounted with a digital camera and a global positioning system (GPS) tracker. The aim is to use the images acquired by the UAV to define the geometry of the floating cover using photogrammetry. In this manner, any changes in the geometry of the floating cover due to forces acting beneath resulting from its deployment and usage can be determined. The time-scale for these changes is in terms of weeks and months. The change in the geometry can be implemented as input conditions to a finite element model (FEM) for stress prediction. This will facilitate the determination of the state of distress of the floating cover. This paper investigates the possibility of using data recorded from a UAV to predict the strain level and assess the health of such structures. An investigation was first conducted on a laboratory sized membrane structure instrumented with strain gauges for comparison against strains, which were computed from 3D scans of the membrane geometry. Upon validating the technique in the laboratory, it was applied to a more realistic scenario: an outdoor test membrane structure and capable UAV were constructed to see if the shape of the membrane could be computed. The membrane displacements were then used to calculate the membrane stress and strain, state demonstrating a new way to perform structural health monitoring on membrane structures.

Interdisciplinary Graduate Program: Rural Early Intervention Specialists for Low Incidence Disabilities (REIS/LID). Final Grant Performance Report [and] REIS/LID Student Guide.

ERIC Educational Resources Information Center

Maine Univ., Orono. Center for Community Inclusion.

This final report describes accomplishments and activities of a 3-year federally funded project of the University of Maine to develop and deliver a graduate Master's degree program in early intervention for infants and young children with low incidence disabilities. A curriculum was designed to prepare professionals to provide culturally relevant,…

On-Chip Hardware for Cell Monitoring: Contact Imaging and Notch Filtering

DTIC Science & Technology

2005-07-07

a polymer carrier. Spectrophotometer chosen and purchased for testing optical filters and materials. Characterization and comparison of fabricated...reproducibility of behavior. Multi-level SU8 process developed. Optimization of actuator for closing vial lids and development of lid sealing technology is...bending angles characterized as a function of temperature in NaDBS solution. " Photopatternable polymers are a viable interim packaging solution; through

Development of sustainable stormwater management using simulation-optimization approach under climate change

NASA Astrophysics Data System (ADS)

Huang, Yu-ru; Tung, Ching-pin

2015-04-01

Climate change had altered the hydrological processes globally with result that the extreme events have an increase in both the magnitude and the frequency. In particular, the high intensity rainfall cause the severe flooding had significantly impacted on human life and property in recently year. The traditional facility to handle runoff is the drainage system which is designed in accordance with the intensity-duration-frequency (IDF) curve. However, the flooding occurs once the drainage capacity is overwhelmed by excess stormwater. Thus the general solution are that expanding and upgrading the existing drainage system or increasing the design return period for new development areas to reduce flooding. Besides, another technique which is low impact development(LID) is regarded as more sustainable solution for stormwater management. The concept of LID is to control stormwater at the source by decentralized practices and mimic the predevelopment hydrologic conditions including storage, retention and high rate of infiltration. In contrast to conventional drainage system aims to move runoff away as quickly as possible, the LID approach attempts to keep runoff on site to reduce peak and volume of flow. The purpose of this research is to identify the most cost-effective measures for stormwater management after the analysis of the strategies combining drainage system and LID on various land use planning. The case study is a rural community in Hsinchu in Taiwan, and having residential areas, farms and pond. It is assumed that two land use layout are planned and drainage system are designed for 2-,and 5-year return period events. On the other hand, three LID technologies, namely green roof, porous pavement and rain barrel, are selected to place in the scenario of the drainage system for 2-year return period event, and the minimal peak flow is target to optimize LID placement by simulated annealing algorithm. Moreover, the design storm under climate change are derived from the revised IDF curve. After that the storm water management model (SWMM) is used to simulate these strategies for a spectrum of design storms, the cost and the benefit can be analyzed to provide government an advice in developing stormwater management under uncertain conditions of climate change.

Optimal selection and placement of green infrastructure to reduce impacts of land use change and climate change on hydrology and water quality: An application to the Trail Creek Watershed, Indiana.

PubMed

Liu, Yaoze; Theller, Lawrence O; Pijanowski, Bryan C; Engel, Bernard A

2016-05-15

The adverse impacts of urbanization and climate change on hydrology and water quality can be mitigated by applying green infrastructure practices. In this study, the impacts of land use change and climate change on hydrology and water quality in the 153.2 km(2) Trail Creek watershed located in northwest Indiana were estimated using the Long-Term Hydrologic Impact Assessment-Low Impact Development 2.1 (L-THIA-LID 2.1) model for the following environmental concerns: runoff volume, Total Suspended Solids (TSS), Total Phosphorous (TP), Total Kjeldahl Nitrogen (TKN), and Nitrate+Nitrite (NOx). Using a recent 2001 land use map and 2050 land use forecasts, we found that land use change resulted in increased runoff volume and pollutant loads (8.0% to 17.9% increase). Climate change reduced runoff and nonpoint source pollutant loads (5.6% to 10.2% reduction). The 2050 forecasted land use with current rainfall resulted in the largest runoff volume and pollutant loads. The optimal selection and placement of green infrastructure practices using L-THIA-LID 2.1 model were conducted. Costs of applying green infrastructure were estimated using the L-THIA-LID 2.1 model considering construction, maintenance, and opportunity costs. To attain the same runoff volume and pollutant loads as in 2001 land uses for 2050 land uses, the runoff volume, TSS, TP, TKN, and NOx for 2050 needed to be reduced by 10.8%, 14.4%, 13.1%, 15.2%, and 9.0%, respectively. The corresponding annual costs of implementing green infrastructure to achieve the goals were $2.1, $0.8, $1.6, $1.9, and $0.8 million, respectively. Annual costs of reducing 2050 runoff volume/pollutant loads were estimated, and results show green infrastructure annual cost greatly increased for larger reductions in runoff volume and pollutant loads. During optimization, the most cost-efficient green infrastructure practices were selected and implementation levels increased for greater reductions of runoff and nonpoint source pollutants. Copyright © 2016 Elsevier B.V. All rights reserved.

Filter Measurement System for Nuclear Material Storage Canisters. End of Year Report FY 2013

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moore, Murray E.; Reeves, Kirk P.

2014-02-03

A test system has been developed at Los Alamos National Laboratory to measure the aerosol collection efficiency of filters in the lids of storage canisters for special nuclear materials. Two FTS (filter test system) devices have been constructed; one will be used in the LANL TA-55 facility with lids from canisters that have stored nuclear material. The other FTS device will be used in TA-3 at the Radiation Protection Division’s Aerosol Engineering Facility. The TA-3 system will have an expanded analytical capability, compared to the TA-55 system that will be used for operational performance testing. The LANL FTS is intendedmore » to be automatic in operation, with independent instrument checks for each system component. The FTS has been described in a complete P&ID (piping and instrumentation diagram) sketch, included in this report. The TA-3 FTS system is currently in a proof-of-concept status, and TA-55 FTS is a production-quality prototype. The LANL specification for (Hagan and SAVY) storage canisters requires the filter shall “capture greater than 99.97% of 0.45-micron mean diameter dioctyl phthalate (DOP) aerosol at the rated flow with a DOP concentration of 65±15 micrograms per liter”. The percent penetration (PEN%) and pressure drop (DP) of fifteen (15) Hagan canister lids were measured by NFT Inc. (Golden, CO) over a period of time, starting in the year 2002. The Los Alamos FTS measured these quantities on June 21, 2013 and on Oct. 30, 2013. The LANL(6-21-2013) results did not statistically match the NFT Inc. data, and the LANL FTS system was re-evaluated, and the aerosol generator was replaced and the air flow measurement method was corrected. The subsequent LANL(10-30-2013) tests indicate that the PEN% results are statistically identical to the NFT Inc. results. The LANL(10-30-2013) pressure drop measurements are closer to the NFT Inc. data, but future work will be investigated. An operating procedure for the FTS (filter test system) was written, and future project milestones are on track for completion« less

Monomerization alters the dynamics of the lid region in Campylobacter jejuni CstII: an MD simulation study.

PubMed

Prabhakar, Pradeep Kumar; Srivastava, Alka; Rao, K Krishnamurthy; Balaji, Petety V

2016-01-01

CstII, a bifunctional (α2,3/8) sialyltransferase from Campylobacter jejuni, is a homotetramer. It has been reported that mutation of the interface residues Phe121 (F121D) or Tyr125 (Y125Q) leads to monomerization and partial loss of enzyme activity, without any change in the secondary or tertiary structures. MD simulations of both tetramer and monomer, with and without bound donor substrate, were performed for the two mutants and WT to understand the reasons for partial loss of activity due to monomerization since the active site is located within each monomer. RMSF values were found to correlate with the crystallographic B-factor values indicating that the simulations are able to capture the flexibility of the molecule effectively. There were no gross changes in either the secondary or tertiary structure of the proteins during MD simulations. However, interface is destabilized by the mutations, and more importantly the flexibility of the lid region (Gly152-Lys190) is affected. The lid region accesses three major conformations named as open, intermediate, and closed conformations. In both Y121Q and F121D mutants, the closed conformation is accessed predominantly. In this conformation, the catalytic base His188 is also displaced. Normal mode analysis also revealed differences in the lid movement in tetramer and monomer. This provides a possible explanation for the partial loss of enzyme activity in both interface mutants. The lid region controls the traffic of substrates and products in and out of the active site, and the dynamics of this region is regulated by tetramerization. Thus, this study provides valuable insights into the role of loop dynamics in enzyme activity of CstII.

The relief of dry eye signs and symptoms using a combination of lubricants, lid hygiene and ocular nutraceuticals.

PubMed

Ngo, William; Srinivasan, Sruthi; Houtman, Diane; Jones, Lyndon

To determine the combined effect of TheraTears ® Lubricant Eye Drops, TheraTears ® SteriLid Eyelid Cleanser, and TheraTears ® Nutrition on dry eye signs and symptoms. This prospective study enrolled 28 dry eye participants. Participants were instructed to use the Lubricant Eye Drops at least 2-4× a day, SteriLid 1-2× a day, and Nutrition 3 gel caps once a day. Participants were followed up at baseline, 1 month and 3 months. Outcome variables were the Ocular Surface Disease Index (OSDI), Symptom Assessment iN Dry Eye (SANDE) questionnaire, non-invasive tear break-up time (NIBUT), osmolarity, number of meibomian glands blocked (#MG blocked), meibum quality, eyelid margin features, Schirmer's test, tear film lipid layer thickness (LLT), meniscus height, corneal and conjunctival staining. Twenty participants (mean age=43, from 23 to 66, 17F, 3M) completed the study. Participants reported having used, on average, the Lubricant Eye Drop 2.4×/day, the SteriLid 1.1×/day, and the Nutrition 3 gel caps 1×/day. There was a significant change over time (p<0.05) for OSDI (-21.2 points), SANDE (-32.4 points), NIBUT (+0.43s), eyelid margin features (-1.1 grade), meibum quality (-1.0 grade), and #MG blocked (-4.0 glands). By using a combination of TheraTears ® Lubricant Eye Drop, SteriLid, and Nutrition, patients experience significant relief in both dry eye symptoms and signs. Copyright © 2016 Spanish General Council of Optometry. Published by Elsevier España, S.L.U. All rights reserved.

DEBS - a unification theory for dry eye and blepharitis.

PubMed

Rynerson, James M; Perry, Henry D

2016-01-01

For many years, blepharitis and dry eye disease have been thought to be two distinct diseases, and evaporative dry eye distinct from aqueous insufficiency. In this treatise, we propose a new way of looking at dry eye, both evaporative and insufficiency, as the natural sequelae of decades of chronic blepharitis. Dry eye is simply the late form and late manifestation of one disease, blepharitis. We suggest the use of a new term in describing this one chronic disease, namely dry eye blepharitis syndrome (DEBS). Bacteria colonize the lid margin within a structure known as a biofilm. The biofilm allows for population densities that initiate quorum-sensing gene activation. These newly activated gene products consist of inflammatory virulence factors, such as exotoxins, cytolytic toxins, and super-antigens, which are then present for the rest of the patient's life. The biofilm never goes away; it only thickens with age, producing increasing quantities of bacterial virulence factors, and thus, increasing inflammation. These virulence factors are likely the culprits that first cause follicular inflammation, then meibomian gland dysfunction, aqueous insufficiency, and finally, after many decades, lid destruction. We suggest that there are four stages of DEBS which correlate with the clinical manifestations of folliculitis, meibomitis, lacrimalitis, and finally lid structure damage evidenced by entropion, ectropion, and floppy eyelid syndrome. When one fully understands the structure and location of the glands within the lid, it becomes easy to understand this staged disease process. The longer a gland can resist the relentless encroachment of the invading biofilm, the longer it can maintain normal function. The stages depend purely on anatomy and years of biofilm presence. Dry eye now becomes a very easy disease to understand. We feel that dry eye should be treated and prevented by early and routine biofilm removal through electromechanical lid margin debridement.

Risk factors for contact lens bacterial contamination during continuous wear.

PubMed

Szczotka-Flynn, Loretta B; Bajaksouzian, Saralee; Jacobs, Michael R; Rimm, Alfred

2009-11-01

Microbial contamination of contact lenses is associated with corneal infection and inflammation. This study determined the microbiological, clinical, and demographic factors that are associated with bacterial contamination of a silicone hydrogel contact lens when worn for continuous wear (CW). Two hundred five healthy subjects were enrolled in the Longitudinal Analysis of Silicone Hydrogel Contact Lens Study and were fitted with lotrafilcon A lenses for monthly CW and followed for 1 year. Lenses were aseptically removed after 1 week and 4 months of wear and cultured using an agar sandwich technique. Lids and conjunctiva were routinely cultured at baseline and after 1 week and 4 months of CW. Lenses and ocular sites were considered to have substantial microbial bioburden when they harbored pathogenic organisms or high levels of commensal organisms. Univariate and multivariate logistic regression analyses were conducted to examine whether substantial conjunctival or lid bioburden, subject demographics, lens-wearing history, symptoms, and biomicroscopic signs were associated with lens bioburden. About one third (32.4%) of subjects had substantial bacterial bioburden in either eye across multiple visits. Over half (53.2%) and about one tenth (11.7%) of subjects had substantial lid and conjunctival bioburden, respectively, and 11.2% discontinued because of discomfort. The adjusted odds ratios (and 95% confidence intervals) for presence of substantial lens bioburden were 2.49 (1.17-5.30), 4.24 (1.45-12.40), and 4.11 (1.17-14.46) for substantial lid bioburden, substantial conjunctival bioburden, and lens discomfort, respectively. Bacterial contamination of silicone hydrogel contact lenses is common during CW. Substantial lens bioburden is associated with discomfort precluding successful CW. The presence of substantial lid and conjunctival bioburden is associated with a 2.5-fold and more than fourfold greater risk of substantial lens bioburden and is likely the major route of contamination.

Further biochemical characterization of human pancreatic lipase-related protein 2 expressed in yeast cells.

PubMed

Eydoux, Cécilia; De Caro, Josiane; Ferrato, Francine; Boullanger, Paul; Lafont, Dominique; Laugier, René; Carrière, Frédéric; De Caro, Alain

2007-07-01

Recombinant human pancreatic lipase-related protein 2 (rHPLRP2) was produced in the protease A-deficient yeast Pichia pastoris. A major protein with a molecular mass of 50 kDa was purified from the culture medium using SP-Sepharose and Mono Q chromatography. The protein was found to be highly sensitive to the proteolytic cleavage of a peptide bond in the lid domain. The proteolytic cleavage process occurring in the lid affected both the lipase and phospholipase activities of rHPLRP2. The substrate specificity of the nonproteolyzed rHPLRP2 was investigated using pH-stat and monomolecular film techniques and various substrates (glycerides, phospholipids, and galactolipids). All of the enzyme activities were maximum at alkaline pH values and decreased in the pH 5-7 range corresponding to the physiological conditions occurring in the duodenum. rHPLRP2 was found to act preferentially on substrates forming small aggregates in solution (monoglycerides, egg phosphatidylcholine, and galactolipids) rather than on emulsified substrates such as triolein and diolein. The activity of rHPLRP2 on monogalactosyldiglyceride and digalactosyldiglyceride monomolecular films was determined and compared with that of guinea pig pancreatic lipase-related protein 2, which shows a large deletion in the lid domain. The presence of a full-length lid domain in rHPLRP2 makes it possible for enzyme activity to occur at higher surface pressures. The finding that the inhibition of nonproteolyzed rHPLRP2 by tetrahydrolipstatin and diethyl-p-nitrophenyl phosphate does not involve any bile salt requirements suggests that the rHPLRP2 lid adopts an open conformation in aqueous media.

Temperatures of the Ocular Surface, Lid, and Periorbital Regions of Sjögren's, Evaporative, and Aqueous-Deficient Dry Eyes Relative to Normals.

PubMed

Abreau, Kerstin; Callan, Christine; Kottaiyan, Ranjini; Zhang, Aizhong; Yoon, Geunyoung; Aquavella, James V; Zavislan, James; Hindman, Holly B

2016-01-01

To compare the temperatures of the ocular surface, eyelid, and periorbital skin in normal eyes with Sjögren's syndrome (SS) eyes, evaporative dry eyes (EDE), and aqueous deficient dry eyes (ADDE). 10 eyes were analyzed in each age-matched group (normal, SS, EDE, and ADDE). A noninvasive infrared thermal camera captured two-dimensional images in three regions of interest (ROI) in each of three areas: the ocular surface, the upper eyelid, and the periorbital skin within a controlled environmental chamber. Mean temperatures in each ROI were calculated from the videos. Ocular surface time-segmented cooling rates were calculated over a 5-s blink interval. Relative to normal eyes, dry eyes had lower initial central OSTs (SS -0.71°C, EDE -0.55°C, ADDE -0.95°C, KW P<.0001) and lower central upper lid temperatures (SS -0.24°C, ADDE -0.51°C, and EDE -0.54°C, KW P<.0001). ADDE eyes had the lowest initial central OST (P<.0001), while EDE eyes had the lowest central lid temperature and lower periorbital temperatures (P<.0001). Over the 5-s interblink interval, the greatest rate of temperature loss occurred following eyelid opening, but varied by group (normals -0.52, SS -0.73, EDE -0.63, and ADDE -0.75°C/s). The ADDE group also had the most substantial heat loss over the 5-s interblink interval (-0.97°C). Differences in OST may be related to thermal differences in lids and periorbita along with an altered tear film. Thermography of the ocular surface, lids, and surrounding tissues may help to differentiate between different etiologies of dry eye. Copyright © 2016 Elsevier Inc. All rights reserved.

The identity of the active site of oxalate decarboxylase and the importance of the stability of active-site lid conformations1

PubMed Central

Just, Victoria J.; Burrell, Matthew R.; Bowater, Laura; McRobbie, Iain; Stevenson, Clare E. M.; Lawson, David M.; Bornemann, Stephen

2007-01-01

Oxalate decarboxylase (EC 4.1.1.2) catalyses the conversion of oxalate into carbon dioxide and formate. It requires manganese and, uniquely, dioxygen for catalysis. It forms a homohexamer and each subunit contains two similar, but distinct, manganese sites termed sites 1 and 2. There is kinetic evidence that only site 1 is catalytically active and that site 2 is purely structural. However, the kinetics of enzymes with mutations in site 2 are often ambiguous and all mutant kinetics have been interpreted without structural information. Nine new site-directed mutants have been generated and four mutant crystal structures have now been solved. Most mutants targeted (i) the flexibility (T165P), (ii) favoured conformation (S161A, S164A, D297A or H299A) or (iii) presence (Δ162–163 or Δ162–164) of a lid associated with site 1. The kinetics of these mutants were consistent with only site 1 being catalytically active. This was particularly striking with D297A and H299A because they disrupted hydrogen bonds between the lid and a neighbouring subunit only when in the open conformation and were distant from site 2. These observations also provided the first evidence that the flexibility and stability of lid conformations are important in catalysis. The deletion of the lid to mimic the plant oxalate oxidase led to a loss of decarboxylase activity, but only a slight elevation in the oxalate oxidase side reaction, implying other changes are required to afford a reaction specificity switch. The four mutant crystal structures (R92A, E162A, Δ162–163 and S161A) strongly support the hypothesis that site 2 is purely structural. PMID:17680775

Evaluating the Hydrologic Performance of Low Impact Development Scenarios in a Micro Urban Catchment.

PubMed

Li, Chunlin; Liu, Miao; Hu, Yuanman; Han, Rongqing; Shi, Tuo; Qu, Xiuqi; Wu, Yilin

2018-02-05

As urbanization progresses, increasingly impervious surfaces have changed the hydrological processes in cities and resulted in a major challenge for urban stormwater control. This study uses the urban stormwater model to evaluate the performance and costs of low impact development (LID) scenarios in a micro urban catchment. Rainfall-runoff data of three rainfall events were used for model calibration and validation. The pre-developed (PreDev) scenario, post-developed (PostDev) scenario, and three LID scenarios were used to evaluate the hydrologic performance of LID measures. Using reduction in annual runoff as the goal, the best solutions for each LID scenario were selected using cost-effectiveness curves. The simulation results indicated that the three designed LID scenarios could effectively reduce annual runoff volumes and pollutant loads compared with the PostDev scenario. The most effective scenario (MaxPerf) reduced annual runoff by 53.4%, followed by the sponge city (SpoPerf, 51.5%) and economy scenarios (EcoPerf, 43.1%). The runoff control efficiency of the MaxPerf and SpoPerf scenarios increased by 23.9% and 19.5%, respectively, when compared with the EcoPerf scenario; however, the costs increased by 104% and 83.6%. The reduction rates of four pollutants (TSS, TN, TP, and COD) under the MaxPerf scenario were 59.8-61.1%, followed by SpoPerf (53.9-58.3%) and EcoPerf (42.3-45.4%), and the costs of the three scenarios were 3.74, 3.47, and 1.83 million yuan, respectively. These results can provide guidance to urban stormwater managers in future urban planning to improve urban water security.

Evaluating the Hydrologic Performance of Low Impact Development Scenarios in a Micro Urban Catchment

PubMed Central

Li, Chunlin; Liu, Miao; Hu, Yuanman; Han, Rongqing; Shi, Tuo; Qu, Xiuqi; Wu, Yilin

2018-01-01

As urbanization progresses, increasingly impervious surfaces have changed the hydrological processes in cities and resulted in a major challenge for urban stormwater control. This study uses the urban stormwater model to evaluate the performance and costs of low impact development (LID) scenarios in a micro urban catchment. Rainfall-runoff data of three rainfall events were used for model calibration and validation. The pre-developed (PreDev) scenario, post-developed (PostDev) scenario, and three LID scenarios were used to evaluate the hydrologic performance of LID measures. Using reduction in annual runoff as the goal, the best solutions for each LID scenario were selected using cost-effectiveness curves. The simulation results indicated that the three designed LID scenarios could effectively reduce annual runoff volumes and pollutant loads compared with the PostDev scenario. The most effective scenario (MaxPerf) reduced annual runoff by 53.4%, followed by the sponge city (SpoPerf, 51.5%) and economy scenarios (EcoPerf, 43.1%). The runoff control efficiency of the MaxPerf and SpoPerf scenarios increased by 23.9% and 19.5%, respectively, when compared with the EcoPerf scenario; however, the costs increased by 104% and 83.6%. The reduction rates of four pollutants (TSS, TN, TP, and COD) under the MaxPerf scenario were 59.8–61.1%, followed by SpoPerf (53.9–58.3%) and EcoPerf (42.3–45.4%), and the costs of the three scenarios were 3.74, 3.47 and 1.83 million yuan, respectively. These results can provide guidance to urban stormwater managers in future urban planning to improve urban water security. PMID:29401747

Use of impact fees to incentivize low-impact development and promote compact growth.

PubMed

Lu, Zhongming; Noonan, Douglas; Crittenden, John; Jeong, Hyunju; Wang, Dali

2013-10-01

Low-impact development (LID) is an innovative stormwater management strategy that restores the predevelopment hydrology to prevent increased stormwater runoff from land development. Integrating LID into residential subdivisions and increasing population density by building more compact living spaces (e.g., apartment homes) can result in a more sustainable city by reducing stormwater runoff, saving infrastructural cost, increasing the number of affordable homes, and supporting public transportation. We develop an agent-based model (ABM) that describes the interactions between several decision-makers (i.e., local government, a developer, and homebuyers) and fiscal drivers (e.g., property taxes, impact fees). The model simulates the development of nine square miles of greenfield land. A more sustainable development (MSD) scenario introduces an impact fee that developers must pay if they choose not to use LID to build houses or apartment homes. Model simulations show homeowners selecting apartment homes 60% or 35% of the time after 30 years of development in MSD or business as usual (BAU) scenarios, respectively. The increased adoption of apartment homes results from the lower cost of using LID and improved quality of life for apartment homes relative to single-family homes. The MSD scenario generates more tax revenue and water savings than does BAU. A time-dependent global sensitivity analysis quantifies the importance of socioeconomic variables on the adoption rate of apartment homes. The top influential factors are the annual pay rates (or capital recovery factor) for single-family houses and apartment homes. The ABM can be used by city managers and policymakers for scenario exploration in accordance with local conditions to evaluate the effectiveness of impact fees and other policies in promoting LID and compact growth.

Psychological and school functioning of Latino siblings of children with intellectual disability.

PubMed

Lobato, Debra; Kao, Barbara; Plante, Wendy; Seifer, Ronald; Grullon, Edicta; Cheas, Lydia; Canino, Glorisa

2011-06-01

Siblings of children with disabilities are at risk for internalizing psychological disorders; however, little is known about how culture influences this effect. This study examined the psychological and school functioning of Latino siblings of children with intellectual disability (ID). Participants were 100 Latino (L) and nonLatino (NL) siblings (8-15 years) of children with ID (50 LID, 50 NLID) and 100 Latino and nonLatino control siblings (50 LC, 50 NLC). Siblings, parents, and teachers completed standard questionnaires regarding sibling emotional and behavioral functioning; sibling school report cards were obtained. Analyses of variance were conducted, controlling for parent age and family income; planned contrasts compared LID siblings to the other sibling groups. LID siblings reported significantly more internalizing (t(1) = 2.41, p < .05) and emotional t(1) = 3.06, p < .05) symptoms, poorer awareness of (t(1) = 2.26, p < .01) and greater reluctance to express (t(1) = 3.12, p < .01) their emotions, and more problems in personal adjustment and relationships with parents (t(1) = -2.50, p < .05). Significantly higher percentages of LID siblings scored in the at-risk or clinical range for internalizing and emotional symptoms, and were more likely to score above the clinical cut-off for separation anxiety disorder and to endorse global impairment. LID siblings experienced more school absences and lower academic performance. There were no group differences in externalizing behavior problems, somatic symptoms, or teacher-reported internalizing symptoms. Latino siblings of children with ID are at greater risk for internalizing psychological disorders and greater impairment in personal and school functioning. Results are discussed in terms of their sociocultural significance and clinical implications. © 2011 The Authors. Journal of Child Psychology and Psychiatry © 2011 Association for Child and Adolescent Mental Health.

Repurposing drugs to treat l-DOPA-induced dyskinesia in Parkinson's disease.

PubMed

Johnston, Tom H; Lacoste, Alix M B; Visanji, Naomi P; Lang, Anthony E; Fox, Susan H; Brotchie, Jonathan M

2018-06-01

In this review, we discuss the opportunity for repurposing drugs for use in l-DOPA-induced dyskinesia (LID) in Parkinson's disease. LID is a particularly suitable indication for drug repurposing given its pharmacological diversity, translatability of animal-models, availability of Phase II proof-of-concept (PoC) methodologies and the indication-specific regulatory environment. A compound fit for repurposing is defined as one with appropriate human safety-data as well as animal safety, toxicology and pharmacokinetic data as found in an Investigational New Drug (IND) package for another indication. We first focus on how such repurposing candidates can be identified and then discuss development strategies that might progress such a candidate towards a Phase II clinical PoC. We discuss traditional means for identifying repurposing candidates and contrast these with newer approaches, especially focussing on the use of computational and artificial intelligence (AI) platforms. We discuss strategies that can be categorised broadly as: in vivo phenotypic screening in a hypothesis-free manner; in vivo phenotypic screening based on analogy to a related disorder; hypothesis-driven evaluation of candidates in vivo and in silico screening with a hypothesis-agnostic component to the selection. To highlight the power of AI approaches, we describe a case study using IBM Watson where a training set of compounds, with demonstrated ability to reduce LID, were employed to identify novel repurposing candidates. Using the approaches discussed, many diverse candidates for repurposing in LID, originally envisaged for other indications, will be described that have already been evaluated for efficacy in non-human primate models of LID and/or clinically. Copyright © 2018 Elsevier Ltd. All rights reserved.

Unexpectedly high leprosy seroprevalence detected using a random surveillance strategy in midwestern Brazil: A comparison of ELISA and a rapid diagnostic test.

PubMed

Frade, Marco Andrey C; de Paula, Natália A; Gomes, Ciro M; Vernal, Sebastian; Bernardes Filho, Fred; Lugão, Helena B; de Abreu, Marilda M M; Botini, Patrícia; Duthie, Malcolm S; Spencer, John S; Soares, Rosa Castália F R; Foss, Norma T

2017-02-01

Leprosy diagnosis is mainly based on clinical evaluation, although this approach is difficult, especially for untrained physicians. We conducted a temporary campaign to detect previously unknown leprosy cases in midwestern Brazil and to compare the performance of different serological tests. A mobile clinic was stationed at the main bus terminal in Brasília, Brazil. Volunteers were quizzed and given a clinical exam to allow categorization as either patients, known contacts of patients or non-contacts, and blood was collected to determine anti-PGL-I and anti-LID-1 antibody titers by ELISA and by the NDO-LID rapid test. New cases of leprosy and the impact of performing this broad random surveillance strategy were evaluated. Accuracy values and concordance between the test results were evaluated among all groups. Four hundred thirty-four individuals were evaluated, and 44 (10.1%) were diagnosed with leprosy. Borderline forms were the most frequent presentation. Both tests presented higher positivity in those individuals with multibacillary disease. Serological tests demonstrated specificities arround 70% for anti-PGL-1 and anti-LID ELISA; and arround 40% for NDO-LID. Sensitivities ranged from 48 to 62%. A substantial agreement between NDO-LID and ELISA with concomitant positive results was found within leprosy patients (Kappa index = 0.79 CI95% 0.36-1.22). The unexpectedly high leprosy prevalence in this population indicates ongoing community-based exposure to Mycobacterium leprae antigens and high rates of subclinical infection. All tests showed low specificity and sensitivity values and therefore cannot be considered for use as stand-alone diagnostics. Rather, considering their positivity among MB patients and non-patients, these tests can be considered effective tools for screening and identifying individuals at high risk who might benefit from regular monitoring.

Surveying traffic congestion based on the concept of community structure of complex networks

NASA Astrophysics Data System (ADS)

Ma, Lili; Zhang, Zhanli; Li, Meng

2016-07-01

In this paper, taking the traffic of Beijing city as an instance, we study city traffic states, especially traffic congestion, based on the concept of network community structure. Concretely, using the floating car data (FCD) information of vehicles gained from the intelligent transport system (ITS) of the city, we construct a new traffic network model which is with floating cars as network nodes and time-varying. It shows that this traffic network has Gaussian degree distributions at different time points. Furthermore, compared with free traffic situations, our simulations show that the traffic network generally has more obvious community structures with larger values of network fitness for congested traffic situations, and through the GPSspg web page, we show that all of our results are consistent with the reality. Then, it indicates that network community structure should be an available way for investigating city traffic congestion problems.

Controllable rotating behavior of individual dielectric microrod in a rotating electric field.

PubMed

Liu, Weiyu; Ren, Yukun; Tao, Ye; Li, Yanbo; Chen, Xiaoming

2017-06-01

We report herein controllable rotating behavior of an individual dielectric microrod driven by a background rotating electric field. By disposing or removing structured floating microelectrode, the rigid rod suspended in electrolyte solution accordingly exhibits cofield or antifield rotating motion. In the absence of the ideally polarizable metal surface, the dielectric rod rotates opposite to propagation of electric field, with the measured rotating rate much larger than predicted by Maxwell-Wager interfacial polarization theory incorporating surface conduction of fixed bond charge. Surprisingly, with floating electrode embedded, a novel kind of cofield rotation mode occurs in the presence of induced double-layer polarization, due to the action of hydrodynamic torque from rotating induced-charge electroosmosis. This method of achieving switchable spin modes of dielectric particles would direct implications in constructing flexible electrokinetic framework for analyzing 3D profile of on-chip biomicrofluidic samples. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Developing a Hydrologic Assessment Tool for Designing Bioretention in a watershed

NASA Astrophysics Data System (ADS)

Baek, Sangsoo; Ligaray, Mayzonee; Park, Jeong-Pyo; Kwon, Yongsung; Cho, Kyung Hwa

2017-04-01

Continuous urbanization has negatively impacted the ecological and hydrological environments at the global, regional, and local scales. This issue was addressed by developing Low Impact Development (LID) practices to deliver better hydrologic function and improve the environmental, economic, social and cultural outcomes. This study developed a modeling software to simulate and optimize bioretentions among LID in a given watershed. The model calculated a detailed soil infiltration process in bioretention with hydrological conditions and hydraulic facilities (e.g. riser and underdrain) and also generated an optimized plan using Flow Duration Curve (FDC). The optimization result from the simulation demonstrated that the location and size of bioretention, as well as the soil texture, are important elements for an efficient bioretention. We hope that the developed software in this study could be useful for establishing an appropriate scheme of LID installment

In situ measurements of fuel retention by laser induced desorption spectroscopy in TEXTOR

NASA Astrophysics Data System (ADS)

Zlobinski, M.; Philipps, V.; Schweer, B.; Huber, A.; Stoschus, H.; Brezinsek, S.; Samm, U.; TEXTOR Team

2011-12-01

In future fusion devices such as ITER tritium retention due to tritium co-deposition in mixed material layers can be a serious safety problem. Laser induced desorption spectroscopy (LIDS) can measure the hydrogen content of hydrogenic carbon layers locally on plasma-facing components, while hydrogen is used as a tritium substitute. For several years, this method has been applied in the TEXTOR tokamak in situ during plasma operation to monitor the hydrogen content in space and time. This work shows the LIDS signal reproducibility and studies the effects of different plasma conditions, desorption distances from the plasma and different laser energies using a dedicated sample with constant hydrogen amount. Also the LIDS signal evaluation procedure is described in detail and the detection limits for different conditions in the TEXTOR tokamak are estimated.

A preliminary study of molecular dynamics on reconfigurable computers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wolinski, C.; Trouw, F. R.; Gokhale, M.

2003-01-01

In this paper we investigate the performance of platform FPGAs on a compute-intensive, floating-point-intensive supercomputing application, Molecular Dynamics (MD). MD is a popular simulation technique to track interacting particles through time by integrating their equations of motion. One part of the MD algorithm was implemented using the Fabric Generator (FG)[l I ] and mapped onto several reconfigurable logic arrays. FG is a Java-based toolset that greatly accelerates construction of the fabrics from an abstract technology independent representation. Our experiments used technology-independent IEEE 32-bit floating point operators so that the design could be easily re-targeted. Experiments were performed using both non-pipelinedmore » and pipelined floating point modules. We present results for the Altera Excalibur ARM System on a Programmable Chip (SoPC), the Altera Strath EPlS80, and the Xilinx Virtex-N Pro 2VP.50. The best results obtained were 5.69 GFlops at 8OMHz(Altera Strath EPlS80), and 4.47 GFlops at 82 MHz (Xilinx Virtex-II Pro 2VF50). Assuming a lOWpower budget, these results compare very favorably to a 4Gjlop/40Wprocessing/power rate for a modern Pentium, suggesting that reconfigurable logic can achieve high performance at low power on jloating-point-intensivea pplications.« less

Three Dimensional Thermal Pollution Models. Volume 2; Rigid-Lid Models

NASA Technical Reports Server (NTRS)

Lee, S. S.; Sengupta, S.

1978-01-01

Three versions of rigid lid programs are presented: one for near field simulation; the second for far field unstratified situations; and the third for stratified basins, far field simulation. The near field simulates thermal plume areas, and the far field version simulates larger receiving aquatic ecosystems. Since these versions have many common subroutines, a unified testing is provided, with main programs for the three possible conditions listed.

Trap geometry in three giant montane pitcher plant species from Borneo is a function of tree shrew body size.

PubMed

Chin, Lijin; Moran, Jonathan A; Clarke, Charles

2010-04-01

*Three Bornean pitcher plant species, Nepenthes lowii, N. rajah and N. macrophylla, produce modified pitchers that 'capture' tree shrew faeces for nutritional benefit. Tree shrews (Tupaia montana) feed on exudates produced by glands on the inner surfaces of the pitcher lids and defecate into the pitchers. *Here, we tested the hypothesis that pitcher geometry in these species is related to tree shrew body size by comparing the pitcher characteristics with those of five other 'typical' (arthropod-trapping) Nepenthes species. *We found that only pitchers with large orifices and lids that are concave, elongated and oriented approximately at right angles to the orifice capture faeces. The distance from the tree shrews' food source (that is, the lid nectar glands) to the front of the pitcher orifice precisely matches the head plus body length of T. montana in the faeces-trapping species, and is a function of orifice size and the angle of lid reflexion. *Substantial changes to nutrient acquisition strategies in carnivorous plants may occur through simple modifications to trap geometry. This extraordinary plant-animal interaction adds to a growing body of evidence that Nepenthes represents a candidate model for adaptive radiation with regard to nitrogen sequestration strategies.

Cognitive bias, hand preference and welfare of common marmosets.

PubMed

Gordon, Dianne J; Rogers, Lesley J

2015-01-01

Common marmosets (Callithrix jacchus) have hand preferences for grasping pieces of food and holding them while eating and these are stable throughout adult life. We report here that left-handed marmosets have negative cognitive bias compared to right-handed marmosets. Twelve marmosets were trained to expect a food reward from a bowl with a black lid and not from one with a white lid, or vice versa. In probe tests with ambiguous, grey-lidded bowls a left-handed group (N=7) were less likely to remove the lid to inspect the bowl than a right-handed group (N=5). This difference between left- and right-handed marmosets was not dependent on rate of learning, sex or age. In fact, hand-preference was not associated with rate of learning the task. Furthermore, retrospective examination of colony records of 39 marmosets revealed that more aggression was directed towards left- than right-handed marmosets. Hence, hand preference, which can be measured easily, could serve as an indicator of cognitive bias and may signal a need for particular care in laboratory environments. We explain the results by arguing that hand preference reflects more frequent (or dominant) use of the opposite hemisphere and this predisposes individuals to behave differently. Copyright © 2015 Elsevier B.V. All rights reserved.

Using bipedicled myocutaneous Tripier flap to correct ectropion after excision of lower eyelid basal cell carcinoma.

PubMed

Maghsodnia, Gholamreza; Ebrahimi, Ali; Arshadi, Amirabbas

2011-03-01

Many techniques have been described for correcting ectropion, but when the ectropion follows skin cancer excision, only a technique that replaces missing skin should be used. The bipedicled Tripier flap tends to give some excess bulk at each end but gives an excellent correction of ectropion. The aim of this study was to apply musculocutaneous bipedicled Tripier flap from upper lid for correction of ectropion due to previous excision of lower-lid malignancies and evaluate its outcome. This was a prospective case-series study. In this study, 15 patients (6 women, 9 men), ranging from 35 to 72 years old (mean, 51 years) underwent operation with Tripier flap for reconstruction of ectropion because of basal cell carcinoma (BCC) resection. In patients with ectropion, Tripier flap with or without ear or nasal septal cartilage was used for reconstruction of deformities 3 months after lower-lid reconstruction with local flaps. All patients were satisfied, and ectropion was corrected in all cases. There were no complications such as dry eye or corneal abrasion after operation. Also, we had not any case of ischemic flap. We suggest that Tripier flap is one of the best methods for reconstruction of lower-lid retraction or ectropion. This is a desirable method, functionally and aesthetically.

A mechanism for tectonic deformation on Venus

NASA Technical Reports Server (NTRS)

Phillips, Roger J.

1986-01-01

In the absence of identifiable physiographic features directly associated with plate tectonics, alternate mechanisms are sought for the intense tectonic deformation observed in radar images of Venus. One possible mechanism is direct coupling into an elastic lithosphere of the stresses associated with convective flow in the interior. Spectral Green's function solutions have been obtained for stresses in an elastic lithosphere overlying a Newtonian interior with an exponential depth dependence of viscosity, and a specified surface-density distribution driving the flow. At long wavelengths and for a rigid elastic/fluid boundary condition, horizontal normal stresses in the elastic lid are controlled by the vertical shear stress gradient and are directly proportional to the depth of the density disturbance in the underlying fluid. The depth and strength of density anomalies in the Venusian interior inferred by analyses of long wavelength gravity data suggest that stresses in excess of 100 MPa would be generated in a 10 km thick elastic lid unless a low viscosity channel occurring beneath the lid or a positive viscosity gradient uncouples the flow stresses. The great apparent depth of compensation of topographic features argues against this, however, thus supporting the importance of the coupling mechanism. If there is no elastic lid, stresses will also be very high near the surface, providing also that the viscosity gradient is negative.

Factors confounding impedance catheter volume measurements in vitro.

PubMed

Bielefeld, M R; Cabreriza, S E; Spotnitz, H M

1993-06-01

The impedance catheter allows continuous measurement of ventricular volume. External influences have been described as causing parallel shifts in impedance-measured volumes; however, factors affecting impedance measurements in a nonparallel manner have not been fully characterized. Accordingly, an impedance catheter was placed inside a latex balloon into which known volumes of normal saline solution were injected. Conductive and nonconductive materials were individually placed within the balloon. Impedance was measured with materials touching (T) or not touching (NT) the catheter. Impedance-measured volumes were plotted versus actual volumes. Compared with the line of identity (LID), a statistical difference (p < 0.05) was found in the slopes in the presence of metallic objects only. These included a pacing lead (T, NT) (mT = 1.32m mNT = 1.29 versus mLID = 1.00), titanium (T) (mT = 1.68 versus mLID = 1.00), and aluminum (NT) (mNT = 0.72 versus mLID = 1.00). These changes in slope indicate nonparallel effects on impedance that confound the ability of the impedance catheter to determine volumes in vitro. These observations imply that serial calibration of both the slope constant (alpha) and the intercept (parallel conductance) of impedance may be necessary for in vivo measurements of ventricular volume based on impedance in the presence of metallic objects.

In vitro and in vivo killing of ocular Demodex by tea tree oil

PubMed Central

Gao, Y-Y; Di Pascuale, M A; Li, W; Baradaran-Rafii, A; Elizondo, A; Kuo, C-L; Raju, V K; Tseng, S C G

2005-01-01

Aims: To compare the in vitro killing effect of different agents on Demodex and to report the in vivo killing effect of tea tree oil (TTO) on ocular Demodex. Methods: Survival time of Demodex was measured under the microscope. Sampling and counting of Demodex was performed by a modified method. Results: Demodex folliculorum survived for more than 150 minutes in 10% povidone-iodine, 75% alcohol, 50% baby shampoo, and 4% pilocarpine. However, the survival time was significantly shortened to within 15 minutes in 100% alcohol, 100% TTO, 100% caraway oil, or 100% dill weed oil. TTO’s in vitro killing effect was dose dependent. Lid scrub with 50% TTO, but not with 50% baby shampoo, can further stimulate Demodex to move out to the skin. The Demodex count did not reach zero in any of the seven patients receiving daily lid scrub with baby shampoo for 40–350 days. In contrast, the Demodex count dropped to zero in seven of nine patients receiving TTO scrub in 4 weeks without recurrence. Conclusions: Demodex is resistant to a wide range of antiseptic solutions. Weekly lid scrub with 50% TTO and daily lid scrub with tea tree shampoo is effective in eradicating ocular Demodex. PMID:16234455

From rain tanks to catchments: Use of low-impact development to address hydrologic symptoms of the urban stream syndrome

NASA Astrophysics Data System (ADS)

Grant, S. B.

2015-12-01

Catchment urbanization perturbs the water and sediment budgets of streams, degrades stream health and function, and causes a constellation of flow, water quality and ecological symptoms collectively known as the urban stream syndrome. Low-impact development (LID) technologies address the hydrologic symptoms of the urban stream syndrome by mimicking natural flow paths and restoring a natural water balance. Over annual time scales, the volumes of storm water that should be infiltrated and harvested can be estimated from a catchment-scale water-balance given local climate conditions and pre-urban land cover. For all but the wettest regions of the world, the water balance predicts a much larger volume of storm water runoff should be harvested than infiltrated to restore stream hydrology to a pre-urban state. Efforts to prevent or reverse hydrologic symptoms associated with the urban stream syndrome will therefore require: (1) selecting the right mix of LID technologies that provide regionally tailored ratios of storm water harvesting and infiltration; (2) integrating these LID technologies into next-generation drainage systems; (3) maximizing potential co-benefits including water supply augmentation, flood protection, improved water quality, and urban amenities; and (4) long-term hydrologic monitoring to evaluate the efficacy of LID interventions.

Measuring the Hydraulic Effectiveness of Low Impact Development Practices in a Heavily Urbanised Environment: A Case Study from London, UK

NASA Astrophysics Data System (ADS)

El Hattab, M. H.; Vernon, D.; Mijic, A.

2017-12-01

Low impact development practices (LID) are deemed to have a synergetic effect in mitigating urban storm water flooding. Designing and implementing effective LID practices require reliable real-life data about their performance in different applications; however, there are limited studies providing such data. In this study an innovative micro-monitoring system to assess the performance of porous pavement and rain gardens as retrofitting technologies was developed. Three pilot streets in London, UK were selected as part of Thames Water Utilities Limited's Counters Creek scheme. The system includes a V-notch weir installed at the outlet of each LID device to provide an accurate and reliable quantification over a wide range of discharges. In addition to, a low flow sensor installed downstream of the V-notch to cross-check the readings. Having a flow survey time-series of the pre-retrofitting conditions from the study streets, extensive laboratory calibrations under different flow conditions depicting the exact site conditions were performed prior to installing the devices in the field. The micro-monitoring system is well suited for high-resolution temporal monitoring and enables accurate long-term evaluation of LID components' performance. Initial results from the field validated the robustness of the system in fulfilling its requirements.

SESAME 7363: A new Li(6)D equation of state

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sheppard, Daniel Glen; Kress, Joel David; Crockett, Scott

2015-09-21

A new Equation of State (EOS) for Lithium 6 Deuteride ( 6LiD) was created, sesame 7363. This EOS was released to the user community under “eos-developmental” as sesame 97363. The construction of this new EOS is a modification of a previously released EOS, sesame 7360 1. Sesame 7360 is too stiff (5-10% excess pressure) at high compressions and high temperatures (ρ = 4-110g/cm 3, T = 30-10,000 eV) compared to orbital-free density-functional theory. Sesame 7363 is softer and gives a better representation of the physics over this range without compromising the agreement with the experimental and simulation data that sesamemore » 7360 was based on.« less

Remote sensing applied to numerical modelling. [water resources pollution

NASA Technical Reports Server (NTRS)

Sengupta, S.; Lee, S. S.; Veziroglu, T. N.; Bland, R.

1975-01-01

Progress and remaining difficulties in the construction of predictive mathematical models of large bodies of water as ecosystems are reviewed. Surface temperature is at present the only variable than can be measured accurately and reliably by remote sensing techniques, but satellite infrared data are of sufficient resolution for macro-scale modeling of oceans and large lakes, and airborne radiometers are useful in meso-scale analysis (of lakes, bays, and thermal plumes). Finite-element and finite-difference techniques applied to the solution of relevant coupled time-dependent nonlinear partial differential equations are compared, and the specific problem of the Biscayne Bay and environs ecosystem is tackled in a finite-differences treatment using the rigid-lid model and a rigid-line grid system.

Multilingual Data Selection for Low Resource Speech Recognition

DTIC Science & Technology

2016-09-12

Figure 1: Identification of language clusters using scores from an LID system training languages used in the Base and OP1 evaluation periods of the Babel...the posterior scores over frames. For a set of languages that are used to train the lan- guage identification (LID) network, pairs of languages that...which are combined during test time to produce 10 dimensional language 3854 Figure 3: Identification of language clusters using scores from individually

An Operational Evaluation of Extended-Wear Soft Contact Lenses in an Armored Division.

DTIC Science & Technology

1987-08-01

has been demonstrated in the tarsal portion of the palpebral conjunctiva , usually of the upper . lid (Korb et al., 1983). Termed giant papillary...segment of the eye; any disease that affected the cornea, conjunctiva or sclera; corneal hypoesthesia; low tear breakup time or insufficient...evaluation of the following: lids, conjunctiva , limbus, cornea, anterior chamber, and tarsal plate. . 14 v\\Md rn, , !,F~l *O NO .. W,% Quantification of

Development of a novel disposable lid speculum with a drape.

PubMed

Urano, Toru; Kasaoka, Masataka; Yamakawa, Ryoji; Yukihikotamai; Nakamura, Shoichiro

2013-01-01

To evaluate the clinical use of a newly-developed disposable lid speculum with a drape. LiDrape® is a cylindrical device that consists of two flexible rings of polyacetal resin with a transparent elastic silicone sheet attached to the rings. The novel device holds the eyelids between the rings, and a hole in the center of the device provides a surgical field. We used the novel device in cataract surgery (75 eyes), glaucoma surgery (eleven eyes), vitrectomy (ten eyes), and intravitreal injection (six eyes) and evaluated its clinical efficacy. The LiDrape was easy to attach and detach. The novel device was not detached from the eye during surgery. No eyelashes or secretions from the meibomian glands were seen in the surgical field, and the drape provided a sufficient surgical field. The LiDrape functions as a lid speculum as well as a drape. Our results showed that the novel device is useful for ocular surgeries.

PSD-95 expression controls l-DOPA dyskinesia through dopamine D1 receptor trafficking

PubMed Central

Porras, Gregory; Berthet, Amandine; Dehay, Benjamin; Li, Qin; Ladepeche, Laurent; Normand, Elisabeth; Dovero, Sandra; Martinez, Audrey; Doudnikoff, Evelyne; Martin-Négrier, Marie-Laure; Chuan, Qin; Bloch, Bertrand; Choquet, Daniel; Boué-Grabot, Eric; Groc, Laurent; Bezard, Erwan

2012-01-01

l-DOPA–induced dyskinesia (LID), a detrimental consequence of dopamine replacement therapy for Parkinson’s disease, is associated with an alteration in dopamine D1 receptor (D1R) and glutamate receptor interactions. We hypothesized that the synaptic scaffolding protein PSD-95 plays a pivotal role in this process, as it interacts with D1R, regulates its trafficking and function, and is overexpressed in LID. Here, we demonstrate in rat and macaque models that disrupting the interaction between D1R and PSD-95 in the striatum reduces LID development and severity. Single quantum dot imaging revealed that this benefit was achieved primarily by destabilizing D1R localization, via increased lateral diffusion followed by increased internalization and diminished surface expression. These findings indicate that altering D1R trafficking via synapse-associated scaffolding proteins may be useful in the treatment of dyskinesia in Parkinson’s patients. PMID:23041629

Wind Noise Reduction in a Non-Porous Subsurface Windscreen

NASA Technical Reports Server (NTRS)

Zuckerwar, Allan J.; Shams, Qamar A.; Knight, H. Keith

2012-01-01

Measurements of wind noise reduction were conducted on a box-shaped, subsurface windscreen made of closed cell polyurethane foam. The windscreen was installed in the ground with the lid flush with the ground surface. The wind was generated by means of a fan, situated on the ground, and the wind speed was measured at the center of the windscreen lid with an ultrasonic anemometer. The wind speed was controlled by moving the fan to selected distances from the windscreen. The wind noise was measured on a PCB Piezotronics 3†electret microphone. Wind noise spectra were measured with the microphone exposed directly to the wind (atop the windscreen lid) and with the microphone installed inside the windscreen. The difference between the two spectra comprises the wind noise reduction. At wind speeds of 3, 5, and 7 m/s, the wind noise reduction is typically 15 dB over the frequency range of 0.1-20 Hz.

End of FY2014 Report - Filter Measurement System for Nuclear Material Storage Canisters (Including Altitude Correction for Filter Pressure Drop)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moore, Murray E.; Reeves, Kirk Patrick

2015-02-24

Two LANL FTS (Filter Test System ) devices for nuclear material storage canisters are fully operational. One is located in PF-4 ( i.e. the TA-55 FTS) while the other is located at the Radiation Protection Division’s Aerosol Engineering Facility ( i.e. the TA-3 FTS). The systems are functionally equivalent , with the TA-3 FTS being the test-bed for new additions and for resolving any issues found in the TA-55 FTS. There is currently one unresolved issue regarding the TA-55 FTS device. The canister lid clamp does not give a leak tight seal when testing the 1 QT (quart) or 2more » QT SAVY lids. An adapter plate is being developed that will ensure a correct test configuration when the 1 or 2 QT SAVY lid s are being tested .« less

Non-planar microfabricated gas chromatography column

DOEpatents

Lewis, Patrick R.; Wheeler, David R.

2007-09-25

A non-planar microfabricated gas chromatography column comprises a planar substrate having a plurality of through holes, a top lid and a bottom lid bonded to opposite surfaces of the planar substrate, and inlet and outlet ports for injection of a sample gas and elution of separated analytes. A plurality of such planar substrates can be aligned and stacked to provide a longer column length having a small footprint. Furthermore, two or more separate channels can enable multi-channel or multi-dimensional gas chromatography. The through holes preferably have a circular cross section and can be coated with a stationary phase material or packed with a porous packing material. Importantly, uniform stationary phase coatings can be obtained and band broadening can be minimized with the circular channels. A heating or cooling element can be disposed on at least one of the lids to enable temperature programming of the column.

The suspension (Frost) suture: experience and applications.

PubMed

Connolly, Karen L; Albertini, John G; Miller, Christopher J; Ozog, David M

2015-03-01

The Frost suture is a well-known surgical technique for providing upward tension on the lower lid to prevent or correct ectropion after surgical interventions in the periorbital area. Despite its relatively common use, comprehensive information on executing this technique is not readily available. To review eyelid anatomy, indications, and proper technique for performing the Frost suture, as well as potential complications. A review of the literature on Frost sutures was performed. Cadaveric dissection was performed to demonstrate placement of the Frost suture. The Frost suture is a useful method to reduce the risk of ectropion after surgery near the lower eyelid. Downward pull on the lid can occur with normal wound contracture even if ectropion is not present with the initial repair, reinforcing the need for preventive measures. Potential complications of this technique include superficial skin erosion of the upper lid, corneal abrasion, and blockage of the field of vision while the suture is in place.

[Study on the nitrogen and phosphorus uptake ability of four plants cultivated on floating-bed].

PubMed

Wu, Jian-Qiang; Wang, Min; Wu, Jian; Jiang, Yue; Sun, Cong-Jun; Cao, Yong

2011-04-01

Plant floating-bed tested engineering was constructed for eutrophication control in Dian-shan Lake, the characteristics and nutrient uptake abilities of Canna indica, Iris pseudacorus, Thalia dealbata and Lythrum salicaria were compared. It shows that using upper and lower nylon nets to fix the plants on the floating-bed is beneficial for them to grow and reproduce rapidly. Survival rates of Canna indica, lris pseudacorus, Thalia dealbata and Lythrum salicaria are 83.33%, 83.33%, 76.67% and 53.33% respectively. Ramets of Canna indica and Thalia dealbata are 64 and 78 respectively in November, and the biomass (fresh weight) of these two plants are 32.0 and 38.6 kg per individual plant. Nitrogen (N) and phosphorus (P) content in stems/leaves of Canna indica and Thalia dealbata are greater than those in roots. The ratio between stems/leaves and roots of N, P content in Canna indica are 1.40 and 1.21 respectively, while 1.59 and 1.08 in Thalia dealbata. The difference of cumulative N, P content in plants is mostly on account of different plant biomass. N uptake ability of Thalia dealbata is the highest, which is 457.11 g per square; Canna indica has the highest P uptake ability, which is 41.29 g per square. N, P uptake ability of stems/leaves in Canna indica are 2.17 and 1.86 times higher than that of roots, while 1.73 and 1.17 times higher respectively in Thalia dealbata. Thus, Canna indica and Thalia dealbata are recommended as the floating-bed plants to control the eutrophication in Dian-shan Lake.

40 CFR 65.45 - External floating roof converted into an internal floating roof.

Code of Federal Regulations, 2010 CFR

2010-07-01

... External floating roof converted into an internal floating roof. The owner or operator who elects to... 40 Protection of Environment 15 2010-07-01 2010-07-01 false External floating roof converted into an internal floating roof. 65.45 Section 65.45 Protection of Environment ENVIRONMENTAL PROTECTION...

The Coast Artillery Journal. Volume 58, Number 6, June 1923

DTIC Science & Technology

1923-06-01

far from the shore. THE DARDANELLES EXPEDITIOX 505 At Beach V the defensive arrangements were excellent. A collier , the River Clyde, was utilized by...almost wiped out of existence. About 400 from the collier -assisted by naval personnel employed in constructing a short floating pier from the collier ...to the shore-managed to get ashore, but these were unable to accomplish anything. \\\\Then darkness fell, about a thousand more troops from the collier

Horizontal film balance having wide range and high sensitivity

DOEpatents

Abraham, B.M.; Miyano, K.; Ketterson, J.B.

1981-03-05

A thin-film, horizontal balance instrument is provided for measuring surface tension (surface energy) of thin films suspended on a liquid substrate. The balance includes a support bearing and an optical feedback arrangement for wide-range, high sensitivity measurements. The force on the instrument is balanced by an electromagnet, the current through the magnet providing a measure of the force applied to the instrument. A novel float construction is also disclosed.

Horizontal film balance having wide range and high sensitivity

DOEpatents

Abraham, B.M.; Miyano, K.; Ketterson, J.B.

1983-11-08

A thin-film, horizontal balance instrument is provided for measuring surface tension (surface energy) of thin films suspended on a liquid substrate. The balance includes a support bearing and an optical feedback arrangement for wide-range, high sensitivity measurements. The force on the instrument is balanced by an electromagnet, the current through the magnet providing a measure of the force applied to the instrument. A novel float construction is also disclosed. 5 figs.

Horizontal film balance having wide range and high sensitivity

DOEpatents

Abraham, Bernard M.; Miyano, Kenjiro; Ketterson, John B.

1983-01-01

A thin-film, horizontal balance instrument is provided for measuring surface tension (surface energy) of thin films suspended on a liquid substrate. The balance includes a support bearing and an optical feedback arrangement for wide-range, high sensitivity measurements. The force on the instrument is balanced by an electromagnet, the current through the magnet providing a measure of the force applied to the instrument. A novel float construction is also disclosed.

The Mechanical Performance of Subscale Candidate Elastomer Docking Seals

NASA Technical Reports Server (NTRS)

Bastrzyk, Marta B.; Daniels, Christopher C.

2010-01-01

The National Aeronautics and Space Administration is developing a Low Impact Docking System (LIDS) for future exploration missions. The mechanism is a new state-of-the-art device for in-space assembly of structures and rendezvous of vehicles. At the interface between two pressurized modules, each with a version of the LIDS attached, a composite elastomer-metal seal assembly prevents the breathable air from escaping into the vacuum of space. Attached to the active LIDS, this seal mates against the passive LIDS during docking operation. The main interface seal assembly must exhibit low leak and outgas values, must be able to withstand various harsh space environments, must remain operational over a range of temperatures from -50 C to 75 C, and perform after numerous docking cycles. This paper presents results from a comprehensive study of the mechanical performance of four candidate subscale seal assembly designs at -50, 23, 50, and 75 C test temperatures. In particular, the force required to fully compress the seal during docking, and that which is required for separation during the undocking operation were measured. The height of subscale main interface seal bulbs, as well as the test temperature, were shown to have a significant effect on the forces the main interface seal of the LIDS may experience during docking and undocking operations. The average force values required to fully compress each of the seal assemblies were shown to increase with test temperature by approximately 50% from -50 to 75 C. Also, the required compression forces were shown to increase as the height of the seal bulb was increased. The seal design with the tallest elastomer seal bulb, which was 31% taller than that with the shortest bulb, required force values approximately 45% higher than those for the shortest bulb, independent of the test temperature. The force required to separate the seal was shown to increase with decreasing temperature after 15 hours of simulated docking. No adhesion force was observed at 75 C, while magnitudes of up to 235 lbf were recorded at the refrigerated temperature. In addition, the adhesion force was observed to increase with bulb height. When compared with the LIDS program requirements, the measured compression force values were found to be below the maximum allowable load allotted to the main interface seal. However, the measured adhesion force values at the refrigerated test temperature were found to exceed the program limits.

Laser-Induced Damage with Femtosecond Pulses

NASA Astrophysics Data System (ADS)

Kafka, Kyle R. P.

The strong electric fields of focused femtosecond laser pulses lead to non-equilibrium dynamics in materials, which, beyond a threshold intensity, causes laser-induced damage (LID). Such a strongly non-linear and non-perturbative process renders important LID observables like fluence and intensity thresholds and damage morphology (crater) extremely difficult to predict quantitatively. However, femtosecond LID carries a high degree of precision, which has been exploited in various micro/nano-machining and surface engineering applications, such as human eye surgery and super-hydrophobic surfaces. This dissertation presents an array of experimental studies which have measured the damage behavior of various materials under femtosecond irradiation. Precision experiments were performed to produce extreme spatio-temporal confinement of the femtosecond laser-solid damage interaction on monocrystalline Cu, which made possible the first successful direct-benchmarking of LID simulation with realistic damage craters. A technique was developed to produce laser-induced periodic surface structures (LIPSS) in a single pulse (typically a multi-pulse phenomenon), and was used to perform a pump-probe study which revealed asynchronous LIPSS formation on copper. Combined with 1-D calculations, this new experimental result suggests more drastic electron heating than expected. Few-cycle pulses were used to study the LID performance and morphology of commercial ultra-broadband optics, which had not been systematically studied before. With extensive surface analysis, various morphologies were observed, including LIPSS, swelling (blisters), simple craters, and even ring-shaped structures, which varied depending on the coating design, number of pulses, and air/vacuum test environment. Mechanisms leading to these morphologies are discussed, many of which are ultrafast in nature. The applied damage behavior of multi-layer dielectric mirrors was measured and compared between long pulse (150 ps) and femtosecond (33 fs) regimes for a large number of optics contributed by manufacturers globally. The damage performance of the mirrors in the 150 ps tests was shown to be uncorrelated with the 33 fs tests, which implies that the two regimes are guided by different mechanisms. In fact, one of the worst-performing mirrors in the long-pulse regime turned out to be the best-performer in the femtosecond regime. The broad array of experimental results presented here all found that LID in the femtosecond regime is distinctly different from long pulse damage, and paves multiple pathways into developing the next stage of theoretical models and applications of femtosecond laser-induced damage.

Mantle beneath the Gibraltar Arc from receiver functions

NASA Astrophysics Data System (ADS)

Morais, Iolanda; Vinnik, Lev; Silveira, Graça; Kiselev, Sergey; Matias, Luís

2015-02-01

P and S receiver functions (PRF and SRF) from 19 seismograph stations in the Gibraltar Arc and the Iberian Massif reveal new details of the regional deep structure. Within the high-velocity mantle body below southern Spain the 660-km discontinuity is depressed by at least 20 km. The Ps phase from the 410-km discontinuity is missing at most stations in the Gibraltar Arc. A thin (˜50 km) low-S-velocity layer atop the 410-km discontinuity is found under the Atlantic margin. At most stations the S410p phase in the SRFs arrives 1.0-2.5 s earlier than predicted by IASP91 model, but, for the propagation paths through the upper mantle below southern Spain, the arrivals of S410p are delayed by up to +1.5 s. The early arrivals can be explained by elevated Vp/Vs ratio in the upper mantle or by a depressed 410-km discontinuity. The positive residuals are indicative of a low (˜1.7 versus ˜ 1.8 in IASP91) Vp/Vs ratio. Previously, the low ratio was found in depleted lithosphere of Precambrian cratons. From simultaneous inversion of the PRFs and SRFs we recognize two types of the mantle: `continental' and `oceanic'. In the `continental' upper mantle the S-wave velocity in the high-velocity lid is 4.4-4.5 km s-1, the S-velocity contrast between the lid and the underlying mantle is often near the limit of resolution (0.1 km s-1), and the bottom of the lid is at a depth reaching 90-100 km. In the `oceanic' domain, the S-wave velocities in the lid and the underlying mantle are typically 4.2-4.3 and ˜ 4.0 km s-1, respectively. The bottom of the lid is at a shallow depth (around 50 km), and at some locations the lid is replaced by a low S-wave velocity layer. The narrow S-N-oriented band of earthquakes at depths from 70 to 120 km in the Alboran Sea is in the `continental' domain, near the boundary between the `continental' and `oceanic' domains, and the intermediate seismicity may be an effect of ongoing destruction of the continental lithosphere.

In silico and in vitro methods to optimize the performance of experimental gastroretentive floating mini-tablets.

PubMed

Eberle, Veronika A; Häring, Armella; Schoelkopf, Joachim; Gane, Patrick A C; Huwyler, Jörg; Puchkov, Maxim

2016-01-01

Development of floating drug delivery systems (FDDS) is challenging. To facilitate this task, an evaluation method was proposed, which allows for a combined investigation of drug release and flotation. It was the aim of the study to use functionalized calcium carbonate (FCC)-based lipophilic mini-tablet formulations as a model system to design FDDS with a floating behavior characterized by no floating lag time, prolonged flotation and loss of floating capability after complete drug release. Release of the model drug caffeine from the mini-tablets was assessed in vitro by a custom-built stomach model. A cellular automata-based model was used to simulate tablet dissolution. Based on the in silico data, floating forces were calculated and analyzed as a function of caffeine release. Two floating behaviors were identified for mini-tablets: linear decrease of the floating force and maintaining of the floating capability until complete caffeine release. An optimal mini-tablet formulation with desired drug release time and floating behavior was developed and tested. A classification system for a range of varied floating behavior of FDDS was proposed. The FCC-based mini-tablets had an ideal floating behavior: duration of flotation is defined and floating capability decreases after completion of drug release.

Plant Bioassay of Materials from the Blue River Dredging Project.

DTIC Science & Technology

1981-09-01

percent at nighttime temperature minimum. Day length varied from 14 hr in July to 11.5 hr in mid-October. No sup- plemental artificial lighting was used...included lid until seed germ- ination occurred. After germination , the lids were permanently removed. Common bermuda and C. esculentus were allowed to grow...species. 30. Seed germination and initial growth of red fescue, tall fes- cue, and Kentucky bluegrass were extremely slow. This was a result of the

Preparation and Analysis of Samples for the Third Round Robin Verification Exercise

DTIC Science & Technology

1992-07-01

Hooge 34 Lid instituuts Advies Raad PML Prof. dr. U.A. Th. Brinkman 35 Directeur van het Medisch Biologisch Laboratorium TNO Proft dr. W.R.F. Notten 36...1991 werd uitgevoerd, heeft het Prins Maurits Laboratorium TNO de monsters aangemaakt die bestonden uit rubber, verf en beton. Deze materialen, die...Maurits Laboratorium TNO Chemische Research Prof. dr. G. Dijksrra 10 HBur. NBC-DMKIJOMATIKIO In. A.A.M. Slagveer 11 Lid van de Contact Cominissie NBC

Nanotechnology-Enhanced Lubricants for RF MEMS Switches

DTIC Science & Technology

2011-03-01

and have greater capabilities. 2.1. Problem Background The Air Force employs numerous communication links between space -borne assets, airborne...beyond 10B of rated cold-switched life, such as high-value space -borne assets with 12+ year horizons to deployment. Warm-switched operation refers to...lids for 5 min. at 300W in oxygen 5. Stud bump substrates using a gold- silver alloy wire bonder – packages may be stored 6. Tack seal pre-form to lid

Search for a more adequate test to predict the long-term migration from the PVC gaskets of metal lids into oily foods in glass jars.

PubMed

Graubardt, Nadine; Biedermann, Maurus; Fiselier, Katell; Bolzoni, Luciana; Pedrelli, Turno; Cavalieri, Chiara; Simoneau, Cathérine; Grob, Koni

2009-07-01

As shown previously, the conventional testing procedure for simulating long-term migration from the gaskets of metal closures into oily foods does not adequately reflect reality. It appears to be impossible to accelerate migration to the extent that the situation at the end of the shelf life of a product can be anticipated in a few days or weeks. Therefore, we investigated whether long-term migration could be extrapolated from migration rates determined for new lids. Jars were kept in the normal upright position. Since heat treatment may have a strong temporary impact, migration during the initial heating for pasteurization or sterilization and storage at ambient temperature were determined using different lids. Commercial products were recalled from sales points throughout Europe to determine the real migration over extended periods of time and for jars with differing histories. This migration was compared with data from the short-term testing to investigate whether an empirical relationship could be derived. The results show that the short-term test enables the comparison of lids and plasticizers in the initial phase of migration, but that long-term extrapolation presupposes more complex kinetic modeling. The results also demonstrate that the legal relevance of "official" testing methods should be reconsidered to avoid conflict when food contact materials comply with migration limits in the test but not in actual application.

Suppressed gross erosion of high-temperature lithium via rapid deuterium implantation

DOE PAGES

Abrams, T.; Jaworski, M. A.; Chen, M.; ...

2015-12-17

Lithium-coated high-Z substrates are planned for use in the NSTX-U divertor and are a candidate plasma facing component (PFC) for reactors, but it remains necessary to characterize the gross Li erosion rate under high plasma fluxes (>10 23 m -2 s -1), typical for the divertor region. In this work, a realistic model for the compositional evolution of a Li/D layer is developed that incorporates first principles molecular dynamics (MD) simulations of D diffusion in liquid Li. Predictions of Li erosion from a mixed Li/D material are also developed that include formation of lithium deuteride (LiD). The erosion rate ofmore » Li from LiD is predicted to be significantly lower than from pure Li. This prediction is tested in the Magnum-PSI linear plasma device at ion fluxes of 10 23-10 24 m -2 s -1 and Li surface temperatures. ≤800 °C. Li/LiD coatings ranging in thickness from 0.2 to 500 μm are studied. The dynamic D/Li concentrations are inferred via diffusion simulations. The pure Li erosion rate remains greater than Langmuir Law evaporation, as expected. For mixed-material Li/LiD surfaces, the erosion rates are reduced, in good agreement with modelling in almost all cases. Lastly, these results imply that the temperature limit for a Li-coated PFC may be significantly higher than previously imagined.« less

Light-induced degradation in gallium-doped silicon

NASA Astrophysics Data System (ADS)

Lindroos, Jeanette; Yli-Koski, Marko; Haarahiltunen, Antti; Schubert, Martin C.; Savin, Hele

2012-02-01

Light-induced degradation (LID) is a lifetime-decreasing effect in silicon solar cells attributed to the formation of B-O defect complexes during illumination [1-2]. However, Savin et al. [3] have recently observed degradation similar to LID in B- and P-doped Si contaminated with Cu, suggesting that Cu might be the cause of LID. Since Ga-doped Si is considered a degradation-free option to conventional B-doped Si [2], lifetime stability should also be studied in Cu-contaminated Ga-Si. Hence, in this paper, we intentionally contaminated high-oxygen 0.41 and 10.1 φcm Ga-doped Cz-Si with Cu and subjected the material to illumination. No lifetime degradation was measured with μ-PCD in clean Ga-Si or at low Cu levels, which is in agreement with the previously reported LID-free behavior of Ga-Si [2]. However, at higher Cu levels (20 ppb), a clear lifetime degradation was observed in Ga-Si. This lifetime degradation increased with increasing Cu concentration or with increasing wafer resistivity. [1] J. Schmidt, A.G. Aberle and R. Hezel, 26th IEEE PVSC, Anaheim, CA, USA, p.13-18 (1997). [2] S.W. Glunz, S. Rein, W. Warta, J. Knobloch and W. Wettling. Sol. Energ. Mat. Sol. C. 65, 219-229 (2001). [3] H. Savin, M. Yli-Koski and A. Haarahiltunen. Appl. Phys. Lett. 95, 152111 (2009).

Impact experiments in viscous fluid media

NASA Technical Reports Server (NTRS)

Greeley, R.

1984-01-01

Available phase and group velocity data are inverted by a procedure which includes the effects of transverse anisotropy, anelastic dispersion, sphericity, and gravity. The resulting models, for average Earth, average ocean, and oceanic regions divided according to the age of the ocean floor, are quite different from previous results which ignore the above effects. The models show a low-veocity zone with age dependent anisotropy and velocities higher than derived in previous surface wave studied. The correspondence between the anisotropy variation with age and a physical model based on flow aligned olivine is suggestive. For most of the Earth SHSV in the vicinity of the low-velocity zone. Near the East Pacific Rise, however, SVSH at depth, consistent with ascending flow. Anisotropy is as important as temperature in causing radial and lateral variations in velocity. The models have a high velocity nearly isotropic layer at the top of the mantle that thickens with age. This layer defines the LID, or seismic lithosphere. In the Pacific, the LID thickens with age to a maximum thickness of about 50 km. This thickness is comparable to the thickness of the elastic lithosphere. The LID thickness is thinner than derived using isotropic or pseudo-isotropic procedures A new model for Average Earth is obtained which includes a thin LID. This model extends the fit of a P.R.E.M. type model to shorter period surface waves.

NATIONAL STORMWATER CALCULATOR USER'S GUIDE ...

EPA Pesticide Factsheets

The National Stormwater Calculator is a simple to use tool for computing small site hydrology for any location within the US. It estimates the amount of stormwater runoff generated from a site under different development and control scenarios over a long term period of historical rainfall. The analysis takes into account local soil conditions, slope, land cover and meteorology. Different types of low impact development (LID) practices (also known as green infrastructure) can be employed to help capture and retain rainfall on-site. Future climate change scenarios taken from internationally recognized climate change projections can also be considered. The calculator provides planning level estimates of capital and maintenance costs which will allow planners and managers to evaluate and compare effectiveness and costs of LID controls.The calculator’s primary focus is informing site developers and property owners on how well they can meet a desired stormwater retention target. It can be used to answer such questions as:• What is the largest daily rainfall amount that can be captured by a site in either its pre-development, current, or post-development condition?• To what degree will storms of different magnitudes be captured on site?• What mix of LID controls can be deployed to meet a given stormwater retention target?• How well will LID controls perform under future meteorological projections made by global climate change models?• What are the relativ

NASA Docking System (NDS) Interface Definitions Document (IDD). Revision C, Nov. 2010

NASA Technical Reports Server (NTRS)

2010-01-01

The NASA Docking System (NDS) mating system supports low approach velocity docking and provides a modular and reconfigurable standard interface, supporting crewed and autonomous vehicles during mating and assembly operations. The NDS is NASA's implementation for the emerging International Docking System Standard (IDSS) using low impact docking technology. All NDS configurations can mate with the configuration specified in the IDSS Interface Definition Document (IDD) released September 21, 2010. The NDS evolved from the Low Impact Docking System (LIDS). The acronym international Low Impact Docking System (iLIDS) is also used to describe this system. NDS and iLIDS may be used interchangeability. Some of the heritage documentation and implementations (e.g., software command names) used on NDS will continue to use the LIDS acronym. The NDS IDD defines the interface characteristics and performance capability of the NDS, including uses ranging from crewed to autonomous space vehicles and from low earth orbit to deep space exploration. The responsibility for developing space vehicles and for making them technically and operationally compatible with the NDS rests with the vehicle providers. Host vehicle examples include crewed/uncrewed spacecraft, space station modules, elements, etc. Within this document, any docking space vehicle will be referred to as the host vehicle. This document defines the NDS-to-NDS interfaces, as well as the NDS-to-host vehicle interfaces and performance capability.

Space Environment's Effects on Seal Materials

NASA Technical Reports Server (NTRS)

deGroh, Henry C., III; Daniels, Christopher C.; Dunlap, Patrick; Miller, Sharon; Dever, Joyce; Waters, Deborah; Steinetz, Bruce M.

2007-01-01

A Low Impact Docking System (LIDS) is being developed by the NASA Johnson Space Center to support future missions of the Crew Exploration Vehicle (CEV). The LIDS is androgynous, such that each system half is identical, thus any two vehicles or modules with LIDS can be coupled. Since each system half is a replica, the main interface seals must seal against each other instead of a conventional flat metal surface. These sealing surfaces are also expected to be exposed to the space environment when vehicles are not docked. The NASA Glenn Research Center (NASA GRC) is supporting this project by developing the main interface seals for the LIDS and determining the durability of candidate seal materials in the space environment. In space, the seals will be exposed to temperatures of between 50 to 50 C, vacuum, atomic oxygen, particle and ultraviolet radiation, and micrometeoroid and orbital debris (MMOD). NASA GRC is presently engaged in determining the effects of these environments on our candidate elastomers. Since silicone rubber is the only class of seal elastomer that functions across the expected temperature range, NASA GRC is focusing on three silicone elastomers: two provided by Parker Hannifin (S0-899-50 and S0-383-70) and one from Esterline Kirkhill (ELA-SA-401). Our results from compression set, elastomer to elastomer adhesion, and seal leakage tests before and after various simulated space exposures will be presented.

Can nifekalant hydrochloride be used as a first-line drug for cardiopulmonary arrest (CPA)? : comparative study of out-of-hospital CPA with acidosis and in-hospital CPA without acidosis.

PubMed

Yoshioka, Koichiro; Amino, Mari; Morita, Seiji; Nakagawa, Yoshihide; Usui, Kazutane; Sugimoto, Atsuhiko; Matsuzaki, Atsushi; Deguchi, Yoshiaki; Yamamoto, Isotoshi; Inokuchi, Sadaki; Ikari, Yuji; Kodama, Itsuo; Tanabe, Teruhisa

2006-01-01

Early defibrillation of ventricular tachycardia and fibrillation (VT/VF) is an urgent and most important method of resuscitation for survival in cardiopulmonary arrest (CPA). We have previously reported that nifekalant (NIF), a specific I(Kr) blocker developed in Japan, is effective for lidocaine (LID) resistant VT/VF in out-of-hospital CPA (OHCPA). However, little is known about the differences in the effect of NIF on OHCPA with acidosis and in-hospital CPA (IHCPA) without acidosis. The present study enrolled 91 cases of DC shock resistant VT/VF among 892 cases of CPA that occurred between June 2000 and May 2003. NIF was used (0.15-0.3 mg/kg) after LID according to the cardiopulmonary resuscitation (CPR) algorithm of Tokai University. The defibrillation rate was higher in the NIF group for both OHCPA and IHCPA than for LID alone, and the VT/VF rate reduction effect could be maintained even with acidosis. However, sinus bradycardia in OHCPA, and torsades de pointes in IHCPA were occasionally observed. These differences in adverse effects might be related to the amount of epinephrine, serum potassium levels, serum pH, and interaction with LID. NIF had a favorable defibrillating effect in both CPA groups, and it shows promise of becoming a first-line drug for CPR.

Migration of epoxidised soybean oil from PVC gaskets of commercial lids: simulation of migration under various conditions and screening of food products from Czech markets.

PubMed

Hanušová, Kristýna; Vrbík, Karel; Rajchl, Aleš; Dobiáš, Jaroslav; Sosnovcová, Jitka

2015-01-01

Previous studies have shown that a large number of polyvinylchloride (PVC) lid gaskets exceed the existing migration limits for epoxidised soybean oil (ESBO) and correct prediction of ESBO release into food therefore appears to be a difficult issue. ESBO migration from PVC gaskets of metal closures into food simulants and food products from the Czech market is evaluated during a survey in 2009 and subsequently one in 2012 to assess progress in lid manufacturing and official testing conditions. ESBO migration from lids into various food simulants was studied at various temperatures (25, 40 and 60°C) during storage times up to 12 months. ESBO released into food simulants or food products was transmethylated, derivatised and analysed by GC-MS. The levels of ESBO migration in foodstuffs in 2012 exceeded the specific migration limit (SML) in fewer products in comparison with the previous survey. However, most of the products were analysed at a time far from the expiry date and exceedance of the SML at the end of the product shelf life is not therefore excluded. More severe test conditions (60°C for 10 days) for specific migration given by the current European Union legislation (Regulation (EU) No. 10/2011) still seem to be insufficient for the simulation of ESBO migration during long-term storage.

Circulating levels of IGF-1 directly regulate bone growth and density

PubMed Central

Yakar, Shoshana; Rosen, Clifford J.; Beamer, Wesley G.; Ackert-Bicknell, Cheryl L.; Wu, Yiping; Liu, Jun-Li; Ooi, Guck T.; Setser, Jennifer; Frystyk, Jan; Boisclair, Yves R.; LeRoith, Derek

2002-01-01

IGF-1 is a growth-promoting polypeptide that is essential for normal growth and development. In serum, the majority of the IGFs exist in a 150-kDa complex including the IGF molecule, IGF binding protein 3 (IGFBP-3), and the acid labile subunit (ALS). This complex prolongs the half-life of serum IGFs and facilitates their endocrine actions. Liver IGF-1–deficient (LID) mice and ALS knockout (ALSKO) mice exhibited relatively normal growth and development, despite having 75% and 65% reductions in serum IGF-1 levels, respectively. Double gene disrupted mice were generated by crossing LID+ALSKO mice. These mice exhibited further reductions in serum IGF-1 levels and a significant reduction in linear growth. The proximal growth plates of the tibiae of LID+ALSKO mice were smaller in total height as well as in the height of the proliferative and hypertrophic zones of chondrocytes. There was also a 10% decrease in bone mineral density and a greater than 35% decrease in periosteal circumference and cortical thickness in these mice. IGF-1 treatment for 4 weeks restored the total height of the proximal growth plate of the tibia. Thus, the double gene disruption LID+ALSKO mouse model demonstrates that a threshold concentration of circulating IGF-1 is necessary for normal bone growth and suggests that IGF-1, IGFBP-3, and ALS play a prominent role in the pathophysiology of osteoporosis. PMID:12235108

Outcomes of levator resection at tertiary eye care center in Iran: a 10-year experience.

PubMed

Abrishami, Alireza; Bagheri, Abbas; Salour, Hossein; Aletaha, Maryam; Yazdani, Shahin

2012-02-01

To assess outcomes of levator resection for the surgical correction of congenital and acquired upper lid ptosis in patients with fair to good levator function and evaluation of the relationship between demographic data and success of this operation. In a retrospective study, medical records of patients with blepharoptosis who had undergone levator resection over a 10-year period and were followed for at least 3 months were reviewed. Overall, 136 patients including 60 (44.1%) male and 76 (55.9%) female subjects with a mean age of 20 ± 13.8 years (range, 2 to 80 years) were evaluated, of whom 120 cases (88.2%) had congenital ptosis and the rest had acquired ptosis. The overall success rate after the first operation was 78.7%. The most common complication after the first operation was undercorrection in 26 cases (19.1%), which was more prevalent among young patients (p = 0.06). Lid fissure and margin reflex distance (MRD(1)) also increased after levator resection (p < 0.001). Age, sex, type of ptosis, amblyopia, levator function, MRD(1), lid fissure and spherical equivalent were not predictive of surgical outcomes of levator resection. Levator resection has a high rate of success and few complications in the surgical treatment of congenital and acquired upper lid ptosis with fair to good levator function. Reoperation can be effective in most cases in which levator resection has been performed.

Clinical trial comparing autogenous fascia lata sling and Gore-Tex suspension in bilateral congenital ptosis.

PubMed

Elsamkary, Mahmoud Ahmed; Roshdy, Maged Maher Salib

2016-01-01

To study the effect of autogenous fascia lata sling (AFLS) versus Gore-Tex suspension (GTS) regarding the functional and aesthetic outcomes in patients with bilateral congenital ptosis. A prospective comparative randomized single-center study enrolled 110 patients with bilateral congenital ptosis. One group (n=55) underwent AFLS and the second group (n=55) underwent GTS. Exclusion criteria were good levator function, absent Bell's phenomenon, and abnormal ocular motility. Follow-up period was 2 years. Functional outcome was measured from digital photos by analysis of upper eyelid margin position relative to the superior limbus and classified as very good (<3 mm), good (3-5 mm), poor (>5 mm), and recurrent. Aesthetic outcome was assessed in terms of lid contour, symmetry of eyelid height, and lid crease presence. Complications were also reported. Failure rate (recurrence and complications) was less in AFLS (P=0.035). Symmetrical lid height and good contour were more frequently attained by AFLS (P=0.007 and 0.047, respectively). However, the frequency of very good, good, poor, recurrence, lagopthalmos, ectropion, infection, and formed lid crease individually showed no statistically significant difference (P=0.252, 0.482, 1, 0.489, 0.438, 1, 0.618, and 0.506, respectively). AFLS is a better choice in surgery for patients with bilateral congenital ptosis because it has fewer complications and a lesser recurrence rate than GTS.

The lid domain of the MCP hydrolase DxnB2 contributes to the reactivity towards recalcitrant PCB metabolites

PubMed Central

Yam, Katherine C.; Ghosh, Subhangi; Bolin, Jeffrey T.; Eltis, Lindsay D.

2013-01-01

DxnB2 and BphD are meta-cleavage product (MCP) hydrolases that catalyze C-C bond hydrolysis of the biphenyl metabolite 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid (HOPDA). BphD is a bottleneck in the bacterial degradation of polychlorinated biphenyls (PCBs) by the Bph catabolic pathway due in part to inhibition by 3-Cl HOPDAs. By contrast, DxnB2 from Sphingomonas wittichii RW1 catalyzes the hydrolysis of 3-Cl HOPDAs more efficiently. X-ray crystallographic studies of the catalytically inactive S105A variant of DxnB2 complexed with 3-Cl HOPDA revealed a binding mode in which C1 through C6 of the dienoate are coplanar. The chlorine substituent is accommodated by a hydrophobic pocket that is larger than the homologous site in BphDLB400 from Burkholderia xenovorans LB400. The planar binding mode observed in the crystalline complex was consistent with the hyper- and hypsochromically-shifted absorption spectra of 3-Cl and 3,9,11-triCl HOPDA, respectively, bound to S105A in solution. Moreover, ESred, an intermediate possessing a bathochromically-shifted spectrum observed in the turnover of HOPDA, was not detected, suggesting that substrate destabilization was rate-limiting in the turnover of these PCB metabolites. Interestingly, electron density for the first α-helix of the lid domain was poorly defined in the dimeric DxnB2 structures, unlike in the tetrameric BphDLB400. Structural comparison of MCP hydrolases identified the NC-loop, connecting the lid to the α/β-hydrolase core domain, as a determinant in oligomeric state and suggests its involvement in catalysis. Finally, an increased mobility of the DxnB2 lid may contribute to the enzyme’s ability to hydrolyze PCB metabolites, highlighting how lid architecture contributes to substrate specificity in α/β-hydrolases. PMID:23879719

DEBS – a unification theory for dry eye and blepharitis

PubMed Central

Rynerson, James M; Perry, Henry D

2016-01-01

For many years, blepharitis and dry eye disease have been thought to be two distinct diseases, and evaporative dry eye distinct from aqueous insufficiency. In this treatise, we propose a new way of looking at dry eye, both evaporative and insufficiency, as the natural sequelae of decades of chronic blepharitis. Dry eye is simply the late form and late manifestation of one disease, blepharitis. We suggest the use of a new term in describing this one chronic disease, namely dry eye blepharitis syndrome (DEBS). Bacteria colonize the lid margin within a structure known as a biofilm. The biofilm allows for population densities that initiate quorum-sensing gene activation. These newly activated gene products consist of inflammatory virulence factors, such as exotoxins, cytolytic toxins, and super-antigens, which are then present for the rest of the patient’s life. The biofilm never goes away; it only thickens with age, producing increasing quantities of bacterial virulence factors, and thus, increasing inflammation. These virulence factors are likely the culprits that first cause follicular inflammation, then meibomian gland dysfunction, aqueous insufficiency, and finally, after many decades, lid destruction. We suggest that there are four stages of DEBS which correlate with the clinical manifestations of folliculitis, meibomitis, lacrimalitis, and finally lid structure damage evidenced by entropion, ectropion, and floppy eyelid syndrome. When one fully understands the structure and location of the glands within the lid, it becomes easy to understand this staged disease process. The longer a gland can resist the relentless encroachment of the invading biofilm, the longer it can maintain normal function. The stages depend purely on anatomy and years of biofilm presence. Dry eye now becomes a very easy disease to understand. We feel that dry eye should be treated and prevented by early and routine biofilm removal through electromechanical lid margin debridement. PMID:28003734

A multi-stakeholder framework for urban runoff quality management: Application of social choice and bargaining techniques.

PubMed

Ghodsi, Seyed Hamed; Kerachian, Reza; Zahmatkesh, Zahra

2016-04-15

In this paper, an integrated framework is proposed for urban runoff management. To control and improve runoff quality and quantity, Low Impact Development (LID) practices are utilized. In order to determine the LIDs' areas and locations, the Non-dominated Sorting Genetic Algorithm-II (NSGA-II), which considers three objective functions of minimizing runoff volume, runoff pollution and implementation cost of LIDs, is utilized. In this framework, the Storm Water Management Model (SWMM) is used for stream flow simulation. The non-dominated solutions provided by the NSGA-II are considered as management scenarios. To select the most preferred scenario, interactions among the main stakeholders in the study area with conflicting utilities are incorporated by utilizing bargaining models including a non-cooperative game, Nash model and social choice procedures of Borda count and approval voting. Moreover, a new social choice procedure, named pairwise voting method, is proposed and applied. Based on each conflict resolution approach, a scenario is identified as the ideal solution providing the LIDs' areas, locations and implementation cost. The proposed framework is applied for urban water quality and quantity management in the northern part of Tehran metropolitan city, Iran. Results show that the proposed pairwise voting method tends to select a scenario with a higher percentage of reduction in TSS (Total Suspended Solid) load and runoff volume, in comparison with the Borda count and approval voting methods. Besides, the Nash method presents a management scenario with the highest cost for LIDs' implementation and the maximum values for percentage of runoff volume reduction and TSS removal. The results also signify that selection of an appropriate management scenario by stakeholders in the study area depends on the available financial resources and the relative importance of runoff quality improvement in comparison with reducing the runoff volume. Copyright © 2016 Elsevier B.V. All rights reserved.

Risk Factors for Contact Lens Bacterial Contamination During Continuous Wear

PubMed Central

Szczotka-Flynn, Loretta B.; Bajaksouzian, Saralee; Jacobs, Michael R.; Rimm, Alfred

2009-01-01

Purpose Microbial contamination of contact lenses is associated with corneal infection and inflammation. This study determined which microbiological, clinical and demographic factors are associated with bacterial contamination of a silicone hydrogel contact lens when worn for continuous wear. Methods Two hundred five normal subjects were enrolled in the Longitudinal Analysis of Silicone Hydrogel (LASH) Contact Lens Study and were fitted with lotrafilcon A lenses for monthly continuous wear and followed for 1 year. Lenses were aseptically removed after 1 week and 4 months of wear and cultured using an agar sandwich technique. Lids and conjunctiva were routinely cultured at baseline, and after 1 week and 4 months of continuous wear. Lenses and ocular sites were considered to have substantial microbial bioburden when they harbored pathogenic organisms or high levels of commensal organisms. Univariate and multivariate logistic regression analyses were conducted to examine whether substantial conjunctival or lid bioburden, subject demographics, lens wearing history, symptoms, and biomicroscopic signs were associated with lens bioburden. Results About one-third (32.4%) of subjects had substantial bacterial bioburden in either eye across multiple visits. Over half (53.2%) and about one-tenth (11.7%) of subjects had substantial lid and conjunctival bioburden, respectively, and 11.2% discontinued due to discomfort. The adjusted odds ratios (and 95% confidence intervals) for presence of substantial lens bioburden were 2.49 (1.17–5.30), 4.24 (1.45–12.40), and 4.11 (1.17–14.46) for substantial lid bioburden, substantial conjunctival bioburden, and lens discomfort, respectively. Conclusions Bacterial contamination of silicone hydrogel contact lenses is common during continuous wear. Substantial lens bioburden is associated with discomfort precluding successful continuous wear. The presence of substantial lid and conjunctival bioburden are associated with a 2.5 fold and over 4 fold greater risk of substantial lens bioburden and are likely the major routes of contamination. PMID:19786927

Furan Levels and Sensory Profiles of Commercial Coffee Products Under Various Handling Conditions.

PubMed

Han, Jeesoo; Kim, Mina K; Lee, Kwang-Geun

2017-11-01

In this study, the levels of furan in coffee with consideration towards common coffee consumption was investigated. The concentration of furan in brewed coffee was the highest among the coffee types studied, with an average of 110.73 ng/mL, followed by canned coffee (28.08 ng/mL) and instant coffee (8.55 ng/mL). In instant and brewed coffee, the furan levels decreased by up to an average of 20% and 22%, after 5 min of pouring in a cup without a lid. The degree of reduction was greater when coffee was served without a lid, regardless of coffee type (P < 0.05). In canned coffee, the level of furan decreased by an average of 14% after storage at 60 °C without a lid, and the degree of furan reduction in coffee was greater in coffee served warm (60 °C) than in coffee served cold (4 °C). A time-dependent intensities of sensory attributes in commercial coffees with various handling condition were different (P < 0.05), suggesting that coffee kept in a cup with lid closed, holds the aroma of coffee longer than coffee in a cup without a lid. Consumption of coffee has increased rapidly in Korea over the past few years. Consequently, the probability of exposure to chemical hazards presence in coffee products increases. Furan is a heterocyclic compound, formed mainly from Maillard reaction, therefore present in coffee products. This work demonstrated the strategy to reduce the levels of furan in coffee products at individual consumer level, by investigating the levels of furan served in common handling scenarios of coffee in Korea: canned coffee, instant coffee, and brewed coffee. Findings of this study can practically guide industry, government, and consumer agencies to reduce the risk exposure to furan during coffee consumptions. © 2017 Institute of Food Technologists®.

The Habitability of a Stagnant-Lid Earth

NASA Astrophysics Data System (ADS)

Tosi, N.; Godolt, M.; Stracke, B.; Ruedas, T.; Grenfell, L.; Höning, D.; Nikolaou, A.; Plesa, A. C.; Breuer, D.; Spohn, T.

2017-12-01

Plate tectonics is a fundamental component for the habitability of the Earth. Yet whether it is a recurrent feature of terrestrial bodies orbiting other stars or unique to the Earth is unknown. The stagnant lid may rather be the most common tectonic expression on such bodies. To understand whether a stagnant-lid planet can be habitable, i.e. host liquid water at its surface, we model the thermal evolution of the mantle, volcanic outgassing of H2O and CO2, and resulting climate of an Earth-like planet lacking plate tectonics. We used a 1D model of parameterized convection to simulate the evolution of melt generation and the build-up of an atmosphere of H2O and CO2 over 4.5 Gyr. We then employed a 1D radiative-convective atmosphere model to calculate the global mean atmospheric temperature and the boundaries of the habitable zone (HZ). The evolution of the interior is characterized by the initial production of a large amount of partial melt accompanied by a rapid outgassing of H2O and CO2. At 1 au, the obtained temperatures generally allow for liquid water on the surface nearly over the entire evolution. While the outer edge of the HZ is mostly influenced by the amount of outgassed CO2, the inner edge presents a more complex behaviour that is dependent on the partial pressures of both gases. At 1 au, the stagnant-lid planet considered would be regarded as habitable. The width of the HZ at the end of the evolution, albeit influenced by the amount of outgassed CO2, can vary in a non-monotonic way depending on the extent of the outgassed H2O reservoir. Our results suggest that stagnant-lid planets can be habitable over geological timescales and that joint modelling of interior evolution, volcanic outgassing, and accompanying climate is necessary to robustly characterize planetary habitability.

Unexpectedly high leprosy seroprevalence detected using a random surveillance strategy in midwestern Brazil: A comparison of ELISA and a rapid diagnostic test

PubMed Central

Bernardes Filho, Fred; de Abreu, Marilda M. M.; Botini, Patrícia; Duthie, Malcolm S.; Spencer, John S.; Soares, Rosa Castália F. R.

2017-01-01

Background Leprosy diagnosis is mainly based on clinical evaluation, although this approach is difficult, especially for untrained physicians. We conducted a temporary campaign to detect previously unknown leprosy cases in midwestern Brazil and to compare the performance of different serological tests. Methods A mobile clinic was stationed at the main bus terminal in Brasília, Brazil. Volunteers were quizzed and given a clinical exam to allow categorization as either patients, known contacts of patients or non-contacts, and blood was collected to determine anti-PGL-I and anti-LID-1 antibody titers by ELISA and by the NDO-LID rapid test. New cases of leprosy and the impact of performing this broad random surveillance strategy were evaluated. Accuracy values and concordance between the test results were evaluated among all groups. Results Four hundred thirty-four individuals were evaluated, and 44 (10.1%) were diagnosed with leprosy. Borderline forms were the most frequent presentation. Both tests presented higher positivity in those individuals with multibacillary disease. Serological tests demonstrated specificities arround 70% for anti-PGL-1 and anti-LID ELISA; and arround 40% for NDO-LID. Sensitivities ranged from 48 to 62%. A substantial agreement between NDO-LID and ELISA with concomitant positive results was found within leprosy patients (Kappa index = 0.79 CI95% 0.36–1.22). Conclusions The unexpectedly high leprosy prevalence in this population indicates ongoing community-based exposure to Mycobacterium leprae antigens and high rates of subclinical infection. All tests showed low specificity and sensitivity values and therefore cannot be considered for use as stand-alone diagnostics. Rather, considering their positivity among MB patients and non-patients, these tests can be considered effective tools for screening and identifying individuals at high risk who might benefit from regular monitoring. PMID:28231244

Effectiveness of low impact development practices in two urbanized watersheds: retrofitting with rain barrel/cistern and porous pavement.

PubMed

Ahiablame, Laurent M; Engel, Bernard A; Chaubey, Indrajeet

2013-04-15

The impacts of urbanization on hydrology and water quality can be minimized with the use of low impact development (LID) practices in urban areas. This study assessed the performance of rain barrel/cistern and porous pavement as retrofitting technologies in two urbanized watersheds of 70 and 40 km(2) near Indianapolis, Indiana. Six scenarios consisting of the watershed existing condition, 25% and 50% implementation of rain barrel/cistern and porous pavement, and 25% rain barrel/cistern combined with 25% porous pavement were evaluated using a proposed LID modeling framework and the Long-Term Hydrologic Impact Assessment (L-THIA)-LID model. The model was calibrated for annual runoff from 1991 to 2000, and validated from 2001 to 2010 for the two watersheds. For the calibration period, R(2) and NSE values were greater than 0.60 and 0.50 for annual runoff and streamflow. Baseflow was not calibrated in this study. During the validation period, R(2) and NSE values were greater than 0.50 for runoff and streamflow, and 0.30 for baseflow in the two watersheds. The various application levels of barrel/cistern and porous pavement resulted in 2-12% reduction in runoff and pollutant loads for the two watersheds. Baseflow loads slightly increased with increase in baseflow by more than 1%. However, reduction in runoff led to reduction in total streamflow and associated pollutant loads by 1-9% in the watersheds. The results also indicate that the application of 50% rain barrel/cistern, 50% porous pavement and 25% rain barrel/cistern combined with 25% porous pavement are good retrofitting options in these watersheds. The L-THIA-LID model can be used to inform management and decision-making for implementation of LID practices at the watershed scale. Copyright © 2013. Published by Elsevier Ltd.

Concrete lunar base investigation

NASA Technical Reports Server (NTRS)

Lin, T. D.; Senseney, Jonathan A.; Arp, Larry Dean; Lindbergh, Charles

1989-01-01

This paper presents results of structural analyses and a preliminary design of a precast, prestressed concrete lunar based subjected to one atmosphere internal pressure. The proposed infrastructure measures 120 ft in diameter and 72 ft in height, providing 33,000 sq ft of work area for scientific and industrial operations. Three loading conditions were considered in the design: (1) during construction; (2) under pressurization; and (3) during an air-leak scenario. A floating foundation, capable of rigid body rotation and translation as the lunar soil beneath it yields, was developed to support the infrastructure and to ensure the air-tightness of the system. Results reveal that it is feasible to use precast, prestressed concrete for construction of large lunar bases on the moon.

Concrete lunar base investigation

NASA Technical Reports Server (NTRS)

Lin, T. D.; Senseny, Jonathan A.; Arp, Larry D.; Lindbergh, Charles

1992-01-01

This paper presents results of structural analyses and a preliminary design of a precast, prestressed concrete lunar base subjected to 1-atm internal pressure. The proposed infrastructure measures 120 ft in diameter and 72 ft in height, providing 33,000 sq ft of work area for scientific and industrial operations. Three loading conditions were considered in the design (1) during construction, (2) under pressurization, and (3) during an air-leak scenario. A floating foundation, capable of rigid body rotation and translation as the lunar soil beneath it yields, was developed to support the infrastructure and to ensure the airtightness of the system. Results reveal that it is feasible to use precast, prestressed concrete for construction of large lunar bases on the Moon.

Numerical modeling of a spherical buoy moored by a cable in three dimensions

NASA Astrophysics Data System (ADS)

Zhu, Xiangqian; Yoo, Wan-Suk

2016-05-01

Floating facilities have been studied based on the static analysis of mooring cables over the past decades. To analyze the floating system of a spherical buoy moored by a cable with a higher accuracy than before, the dynamics of the cables are considered in the construction of the numerical modeling. The cable modeling is established based on a new element frame through which the hydrodynamic loads are expressed efficiently. The accuracy of the cable modeling is verified with an experiment that is conducted by a catenary chain moving in a water tank. In addition, the modeling of a spherical buoy is established with respect to a spherical coordinate in three dimensions, which can suffers the gravity, the variable buoyancy and Froude-Krylov loads. Finally, the numerical modeling for the system of a spherical buoy moored by a cable is established, and a virtual simulation is proceeded with the X- and Y-directional linear waves and the X-directional current. The comparison with the commercial simulation code ProteusDS indicates that the system is accurately analyzed by the numerical modeling. The tensions within the cable, the motions of the system, and the relationship between the motions and waves are illustrated according to the defined sea state. The dynamics of the cables should be considered in analyzing the floating system of a spherical buoy moored by a cable.

Mandibular kinematics represented by a non-orthogonal floating axis joint coordinate system.

PubMed

Leader, Joseph K; Boston, J Robert; Debski, Richard E; Rudy, Thomas E

2003-02-01

There are many methods used to represent joint kinematics (e.g., roll, pitch, and yaw angles; instantaneous center of rotation; kinematic center; helical axis). Often in biomechanics internal landmarks are inferred from external landmarks. This study represents mandibular kinematics using a non-orthogonal floating axis joint coordinate system based on 3-D geometric models with parameters that are "clinician friendly" and mathematically rigorous. Kinematics data for two controls were acquired from passive fiducial markers attached to a custom dental clutch. The geometric models were constructed from MRI data. The superior point along the arc of the long axis of the condyle was used to define the coordinate axes. The kinematic data and geometric models were registered through fiducial markers visible during both protocols. The mean absolute maxima across the subjects for sagittal rotation, coronal rotation, axial rotation, medial-lateral translation, anterior-posterior translation, and inferior-superior translation were 34.10 degrees, 1.82 degrees, 1.14 degrees, 2.31, 21.07, and 6.95 mm, respectively. All the parameters, except for one subject's axial rotation, were reproducible across two motion recording sessions. There was a linear correlation between sagittal rotation and translation, the dominant motion plane, with approximately 1.5 degrees of rotation per millimeter of translation. The novel approach of combining the floating axis system with geometric models succinctly described mandibular kinematics with reproducible and clinician friendly parameters.

The Case for a Heat-Pipe Phase of Planet Evolution on the Moon

NASA Technical Reports Server (NTRS)

Simon, J. I.; Moore, W. B.; Webb, A. A. G.

2015-01-01

The prevalence of anorthosite in the lunar highlands is generally attributed to the flotation of less dense plagioclase in the late stages of the solidification of the lunar magma ocean. It is not clear, however, that these models are capable of producing the extremely high plagioclase contents (near 100%) observed in both Apollo samples and remote sensing data, since a mostly solid lithosphere forms (at 60-70% solidification) before plagioclase feldspar reaches saturation (at approximately 80% solidification). Formation as a floating cumulate is made even more problematic by the near uniformity of the alkali composition of the plagioclase, even as the mafic phases record significant variations in Mg/(Mg+Fe) ratios. These problems can be resolved for the Moon if the plagioclase-rich crust is produced and refined through a widespread episode of heat-pipe magmatism rather than a process dominated by density-driven plagioclase flotation. Heat-pipes are an important feature of terrestrial planets at high heat flow, as illustrated by Io's present activity. Evidence for their operation early in Earth's history suggests that all terrestrial bodies should experience an early episode of heat-pipe cooling. As the Moon likely represents the most wellpreserved example of early planetary thermal evolution in our solar system, studies of the lunar surface and of lunar materials provide useful data to test the idea of a universal model of the way terrestrial bodies transition from a magma ocean state into subsequent single-plate, rigid-lid convection or plate tectonic phases.

Symbolic play of preschoolers with severe communication impairments with autism and other developmental delays: more similarities than differences.

PubMed

Thiemann-Bourque, Kathy S; Brady, Nancy C; Fleming, Kandace K

2012-05-01

Children with autism are often described as having deficient play skills, particularly symbolic play. We compared the play of 35 children with autism to 38 children with other developmental delays. All children were preschool-age and produced less than 20 different words. Results indicated no significant differences across the two groups in their play. Children with autism engaged in more conventional play, that is, putting objects together according to how the toys were constructed (e.g., pieces in a puzzle, lid on a teapot). Results also indicated high correlations between play, language, and cognitive measures. Findings indicate that play relates to language and cognitive levels yet may not discriminate children with autism and children with other developmental delays early in their development.

Symbolic Play of Preschoolers with Severe Communication Impairments with Autism and Other Developmental Delays: More Similarities than Differences

PubMed Central

Brady, Nancy C.; Fleming, Kandace K.

2011-01-01

Children with autism are often described as having deficient play skills, particularly symbolic play. We compared the play of 35 children with autism to 38 children with other developmental delays. All children were preschool-age and produced less than 20 different words. Results indicated no significant differences across the two groups in their play. Children with autism engaged in more conventional play, that is, putting objects together according to how the toys were constructed (e.g., pieces in a puzzle, lid on a teapot). Results also indicated high correlations between play, language, and cognitive measures. Findings indicate that play relates to language and cognitive levels yet may not discriminate children with autism and children with other developmental delays early in their development. PMID:21720725

Investigation of materials for inert electrodes in aluminum electrodeposition cells

NASA Astrophysics Data System (ADS)

Haggerty, J. S.; Sadoway, D. R.

1987-09-01

Work was divided into major efforts. The first was the growth and characterization of specimens; the second was Hall cell performance testing. Cathode and anode materials were the subject of investigation. Preparation of specimens included growth of single crystals and synthesis of ultra high purity powders. Special attention was paid to ferrites as they were considered to be the most promising anode materials. Ferrite anode corrosion rates were studied and the electrical conductivities of a set of copper-manganese ferrites were measured. Float Zone, Pendant Drop Cryolite Experiments were undertaken because unsatisfactory choices of candidate materials were being made on the basis of a flawed set of selection criteria applied to an incomplete and sometimes inaccurate data base. This experiment was then constructed to determine whether the apparatus used for float zone crystal growth could be adapted to make a variety of important based melts and their interactions with candidate inert anode materials. Compositions), driven by our perception that the basis for prior selection of candidate materials was inadequate. Results are presented.

On the effectiveness of smart technologies in the seismic protection of existing buildings Part I: Masonry structures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mandara, A.; Ramundo, F.; Spina, G.

2008-07-08

The first part of a study concerning innovative intervention techniques for dissipate a share of the input seismic energy compatible with the preservation of existing buildings, including historical and monumental constructions, is presented in this paper. The case of a typical scheme of a long-bay box-like masonry building fitted with a dissipative floating roof is analyzed. In the examined building a wide simulation analysis has shown the achievement of a very satisfying performance. Furthermore, the effectiveness of the system can be maximized by means of active or semi-active devices implemented in the floating roof and a significant reduction of themore » seismic impact on the building can be obtained compared with non-controlled or simply passively controlled structure. The results prove the remarkable increase of the energy dissipation capability of the system, as well as the reduction of structural damage, independently of any specific strengthening intervention.« less

A performance comparison of the IBM RS/6000 and the Astronautics ZS-1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, W.M.; Abraham, S.G.; Davidson, E.S.

1991-01-01

Concurrent uniprocessor architectures, of which vector and superscalar are two examples, are designed to capitalize on fine-grain parallelism. The authors have developed a performance evaluation method for comparing and improving these architectures, and in this article they present the methodology and a detailed case study of two machines. The runtime of many programs is dominated by time spent in loop constructs - for example, Fortran Do-loops. Loops generally comprise two logical processes: The access process generates addresses for memory operations while the execute process operates on floating-point data. Memory access patterns typically can be generated independently of the data inmore » the execute process. This independence allows the access process to slip ahead, thereby hiding memory latency. The IBM 360/91 was designed in 1967 to achieve slip dynamically, at runtime. One CPU unit executes integer operations while another handles floating-point operations. Other machines, including the VAX 9000 and the IBM RS/6000, use a similar approach.« less

Spontaneous formation of nanoparticle stripe patterns through dewetting

NASA Astrophysics Data System (ADS)

Huang, Jiaxing; Kim, Franklin; Tao, Andrea R.; Connor, Stephen; Yang, Peidong

2005-12-01

Significant advancement has been made in nanoparticle research, with synthetic techniques extending over a wide range of materials with good control over particle size and shape. A grand challenge is assembling and positioning the nanoparticles in desired locations to construct complex, higher-order functional structures. Controlled positioning of nanoparticles has been achieved in pre-defined templates fabricated by top-down approaches. A self-assembly method, however, is highly desirable because of its simplicity and compatibility with heterogeneous integration processes. Here we report on the spontaneous formation of ordered gold and silver nanoparticle stripe patterns on dewetting a dilute film of polymer-coated nanoparticles floating on a water surface. Well-aligned stripe patterns with tunable orientation, thickness and periodicity at the micrometre scale were obtained by transferring nanoparticles from a floating film onto a substrate in a dip-coating fashion. This facile technique opens up a new avenue for lithography-free patterning of nanoparticle arrays for various applications including, for example, multiplexed surface-enhanced Raman substrates and templated fabrication of higher-order nanostructures.

Low-cost floating emergence net and bottle trap: Comparison of two designs

USGS Publications Warehouse

Cadmus, Pete; Pomeranz, Justin; Kraus, Johanna M.

2016-01-01

Sampling emergent aquatic insects is of interest to many freshwater ecologists. Many quantitative emergence traps require the use of aspiration for collection. However, aspiration is infeasible in studies with large amounts of replication that is often required in large biomonitoring projects. We designed an economic, collapsible pyramid-shaped floating emergence trap with an external collection bottle that avoids the need for aspiration. This design was compared experimentally to a design of similar dimensions that relied on aspiration to ensure comparable results. The pyramid-shaped design captured twice as many total emerging insects. When a preservative was used in bottle collectors, >95% of the emergent abundance was collected in the bottle. When no preservative was used, >81% of the total insects were collected from the bottle. In addition to capturing fewer emergent insects, the traps that required aspiration took significantly longer to sample. Large studies and studies sampling remote locations could benefit from the economical construction, speed of sampling, and capture efficiency.

33 CFR 144.01-1 - Life floats.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Life floats. 144.01-1 Section 144... CONTINENTAL SHELF ACTIVITIES LIFESAVING APPLIANCES Manned Platforms § 144.01-1 Life floats. Each manned platform shall be provided with at least two approved life floats. The life floats shall have sufficient...

33 CFR 144.01-1 - Life floats.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Life floats. 144.01-1 Section 144... CONTINENTAL SHELF ACTIVITIES LIFESAVING APPLIANCES Manned Platforms § 144.01-1 Life floats. Each manned platform shall be provided with at least two approved life floats. The life floats shall have sufficient...

33 CFR 144.01-1 - Life floats.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Life floats. 144.01-1 Section 144... CONTINENTAL SHELF ACTIVITIES LIFESAVING APPLIANCES Manned Platforms § 144.01-1 Life floats. Each manned platform shall be provided with at least two approved life floats. The life floats shall have sufficient...

33 CFR 144.01-1 - Life floats.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Life floats. 144.01-1 Section 144... CONTINENTAL SHELF ACTIVITIES LIFESAVING APPLIANCES Manned Platforms § 144.01-1 Life floats. Each manned platform shall be provided with at least two approved life floats. The life floats shall have sufficient...

33 CFR 144.01-1 - Life floats.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Life floats. 144.01-1 Section 144... CONTINENTAL SHELF ACTIVITIES LIFESAVING APPLIANCES Manned Platforms § 144.01-1 Life floats. Each manned platform shall be provided with at least two approved life floats. The life floats shall have sufficient...

Load assumptions for the landing impact of seaplanes

NASA Technical Reports Server (NTRS)

Taub, Josef

1931-01-01

The formula for the impact of floats must include the enlargement factor itself as well as the type of enlargement. The latter is preferably characterized by the change in surface loading. It is shown that the enlargement of a small seaplane generally results in a changed float (or boat) loading as well as wing loading. The conditions of starting stipulate the retention of the float loading when changing from single-float (boat) to twin-float arrangement. This contingency is followed by an increased impact factor in the twin-float type against the otherwise equivalent single-float type.

Vegetation, substrate and hydrology in floating marshes in the Mississippi river delta plain wetlands, USA

USGS Publications Warehouse

Sasser, C.E.; Gosselink, J.G.; Swenson, E.M.; Swarzenski, C.M.; Leibowitz, N.C.

1996-01-01

In the 1940s extensive floating marshes (locally called 'flotant') were reported and mapped in coastal wetlands of the Mississippi River Delta Plain. These floating marshes included large areas of Panicum hemitomon-dominated freshwater marshes, and Spartina patens/Scirpus olneyi brackish marshes. Today these marshes appear to be quite different in extent and type. We describe five floating habitats and one non-floating, quaking habitat based on differences in buoyancy dynamics (timing and degree of floating), substrate characteristics, and dominant vegetation. All floating marshes have low bulk density, organic substrates. Nearly all are fresh marshes. Panicum hemitomon floating marshes presently occur within the general regions that were reported in the 1940's by O'Neil, but are reduced in extent. Some of the former Panicum hemitomon marshes have been replaced by seasonally or variably floating marshes dominated, or co-dominated by Sagittaria lancifolia or Eleocharis baldwinii. ?? 1996 Kluwer Academic Publishers.

Lattice Boltzmann computation of creeping fluid flow in roll-coating applications

NASA Astrophysics Data System (ADS)

Rajan, Isac; Kesana, Balashanker; Perumal, D. Arumuga

2018-04-01

Lattice Boltzmann Method (LBM) has advanced as a class of Computational Fluid Dynamics (CFD) methods used to solve complex fluid systems and heat transfer problems. It has ever-increasingly attracted the interest of researchers in computational physics to solve challenging problems of industrial and academic importance. In this current study, LBM is applied to simulate the creeping fluid flow phenomena commonly encountered in manufacturing technologies. In particular, we apply this novel method to simulate the fluid flow phenomena associated with the "meniscus roll coating" application. This prevalent industrial problem encountered in polymer processing and thin film coating applications is modelled as standard lid-driven cavity problem to which creeping flow analysis is applied. This incompressible viscous flow problem is studied in various speed ratios, the ratio of upper to lower lid speed in two different configurations of lid movement - parallel and anti-parallel wall motion. The flow exhibits interesting patterns which will help in design of roll coaters.

A Promising Modified Procedure for Upper Eyelid Retraction-Associated Graves' Ophthalmopathy: Transconjunctival Lateral Levator Aponeurectomy.

PubMed

Khatavi, Fatima; Nasrollahi, Kobra; Zandi, Alireza; Panahi, Maryam; Mortazavi, Mahshid; Pourazizi, Mohsen; Ranjbar-Omidi, Behzad

2017-01-01

Upper eyelid retraction is a characteristic feature of thyroid eye disease, including Graves' orbitopathy. In this study, a new surgical technique for correction of lid retraction secondary to Graves' orbitopathy is described. Sixteen eyelids of patients older than 18 years old underwent surgical correction for moderate to severe lid retraction secondary to Graves' orbitopathy. In this procedure, levator aponeurectomy was performed via a transconjunctival approach. Upper marginal reflex distance (MRD1) was measured before the surgery and at 1 week, 3 months, and 6 months after the surgery. MRD1 was reduced significantly from preoperatively (mean: 7.84 mm) to 1 week after the surgery (mean: 3.59 mm) (P < 0.001). Three and six months after surgery, mean MRD1 was 5.09 mm and 5.10 mm, respectively, showing that lid retraction was improved significantly (P < 0.001). Lateral levator aponeurectomy via the transconjunctival approach is a simple, scar-less, quick procedure that has optimal stable outcome.

Mechanisms underlying changes in indomethacin solubility with local anesthetics and related basic additives

NASA Astrophysics Data System (ADS)

Shimada, Yohsuke; Tateuchi, Ryo; Chatani, Hitoshi; Goto, Satoru

2018-03-01

Indomethacin (IND), an acidic nonsteroidal anti-inflammatory drug, and lidocaine (LID), a local anesthetic (LA), form a eutectic complex when mixed, with a lower melting point. The aqueous solubility of the mixture is greater than that of IND or LID alone, improving the bioavailability of IND. Therefore, IND and LID can be used to model changes in efficacy caused by physicochemical interactions between drugs. In this study, the intermolecular interactions between IND and structurally similar LAs were examined by measuring solubility and analyzing thermodynamics using differential scanning calorimetry. The results indicate that the solubility of IND (log S'IND) varies with LA hydrophobicity. Reductions in melting point resulting from mixing IND and LAs contributed to changes in IND solubility, attributable to direct intermolecular interactions between IND and the LAs. In addition, binding energy of IND-LA as in water was calculated, and the values were correlating with the solubility of IND in experiments. Understanding these interactions will help address some of the problems encountered in polypharmacy.

Effects of temperature and surface contamination on D retention in ultrathin Li films on TZM

DOE PAGES

Capece, A. M.; Roszell, J. P.; Skinner, C. H.; ...

2014-10-29

Here in this work, we investigate deuterium retention at the Mo-Li interface by studying thin Li films three monolayers thick on a TZM Mo alloy. Li films at temperatures between 315 and 460 K were exposed to a deuterium ion beam and D retention was measured using temperature programmed desorption. In the absence of oxygen, D is retained as LiD, and the relative amount of retained D decreases with increasing substrate temperature. In three-monolayer thick lithium oxide films, the amount of D retained was 2.5 times higher than the amount retained as LiD in the metallic Li film. However, oxygenmore » reduces the thermal stability of D in the film, causing D 2O and D 2 to be released from the surface at temperatures 150-200 K below the LiD decomposition temperature. These results highlight the importance of maintaining a metallic Li layer for high D retention in Li films on TZM at elevated temperatures.« less

Analysis of tritium production in concentric spheres of oralloy and /sup 6/LiD irradiated by 14-MeV neutrons

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fawcett, L.R. Jr.; Roberts, R.R. II; Hunter, R.E.

1988-03-01

Tritium production and activation of radiochemical detector foils in a sphere of /sup 6/LiD with an oralloy core irradiated by a central source of 14-MeV neutrons have been calculated and compared with experimental measurements. The experimental assembly consisted of an oralloy sphere surrounded by three solid /sup 6/LiD concentric shells with ampules of /sup 6/LiH and /sup 7/LiH and activation foils located in several positions throughout the assembly. The Los Alamos Monte Carlo Neutron Photon Transport Code (MCNP) was used to calculate neutron transport throughout the system, tritium production in the ampules, and foil activation. The overall experimentally observed-to-calculated ratiosmore » of tritium production were 0.996 +- 2.5% in /sup 6/Li ampules and 0.903 +- 5.2% in /sup 7/Li ampules. Observed-to-calculated ratios for foil activation are also presented. 11 refs., 4 figs., 7 tabs.« less

Application of remote sensing for prediction and detection of thermal pollution, phase 2

NASA Technical Reports Server (NTRS)

Veziroglu, T. N.; Lee, S. S.

1975-01-01

The development of a predictive mathematical model for thermal pollution in connection with remote sensing measurements was continued. A rigid-lid model has been developed and its application to far-field study has been completed. The velocity and temperature fields have been computed for different atmospheric conditions and for different boundary currents produced by tidal effects. In connection with the theoretical work, six experimental studies of the two sites in question (Biscayne Bay site and Hutchinson Island site) have been carried out. The temperature fields obtained during the tests at the Biscayne Bay site have been compared with the predictions of the rigid-lid model and these results are encouraging. The rigid-lid model is also being applied to near-field study. Preliminary results for a simple case have been obtained and execution of more realistic cases has been initiated. The development of a free-surface model also been initiated. The governing equations have been formulated and the computer programs have been written.

Effects of temperature and surface contamination on D retention in ultrathin Li films on TZM

DOE Office of Scientific and Technical Information (OSTI.GOV)

Capece, A. M.; Roszell, J. P.; Skinner, C. H.

Here in this work, we investigate deuterium retention at the Mo-Li interface by studying thin Li films three monolayers thick on a TZM Mo alloy. Li films at temperatures between 315 and 460 K were exposed to a deuterium ion beam and D retention was measured using temperature programmed desorption. In the absence of oxygen, D is retained as LiD, and the relative amount of retained D decreases with increasing substrate temperature. In three-monolayer thick lithium oxide films, the amount of D retained was 2.5 times higher than the amount retained as LiD in the metallic Li film. However, oxygenmore » reduces the thermal stability of D in the film, causing D 2O and D 2 to be released from the surface at temperatures 150-200 K below the LiD decomposition temperature. These results highlight the importance of maintaining a metallic Li layer for high D retention in Li films on TZM at elevated temperatures.« less

An Edge-Based Method for the Incompressible Navier-Stokes Equations on Polygonal Meshes

NASA Astrophysics Data System (ADS)

Wright, Jeffrey A.; Smith, Richard W.

2001-05-01

A pressure-based method is presented for discretizing the unsteady incompressible Navier-Stokes equations using hybrid unstructured meshes. The edge-based data structure and assembly procedure adopted lead naturally to a strictly conservative discretization, which is valid for meshes composed of n-sided polygons. Particular attention is given to the construction of a pressure-velocity coupling procedure which is supported by edge data, resulting in a relatively simple numerical method that is consistent with the boundary and initial conditions required by the incompressible Navier-Stokes equations. Edge formulas are presented for assembling the momentum equations, which are based on an upwind-biased linear reconstruction of the velocity field. Similar formulas are presented for assembling the pressure equation. The method is demonstrated to be second-order accurate in space and time for two Navier-Stokes problems admitting an exact solution. Results for several other well-known problems are also presented, including lid-driven cavity flow, impulsively started cylinder flow, and unsteady vortex shedding from a circular cylinder. Although the method is by construction minimalist, it is shown to be accurate and robust for the problems considered.

Electrically floating, near vertical incidence, skywave antenna

DOEpatents

Anderson, Allen A.; Kaser, Timothy G.; Tremblay, Paul A.; Mays, Belva L.

2014-07-08

An Electrically Floating, Near Vertical Incidence, Skywave (NVIS) Antenna comprising an antenna element, a floating ground element, and a grounding element. At least part of said floating ground element is positioned between said antenna element and said grounding element. The antenna is separated from the floating ground element and the grounding element by one or more electrical insulators. The floating ground element is separated from said antenna and said grounding element by one or more electrical insulators.

New insights on poly(vinyl acetate)-based coated floating tablets: characterisation of hydration and CO2 generation by benchtop MRI and its relation to drug release and floating strength.

PubMed

Strübing, Sandra; Abboud, Tâmara; Contri, Renata Vidor; Metz, Hendrik; Mäder, Karsten

2008-06-01

The purpose of this study was to investigate the mechanism of floating and drug release behaviour of poly(vinyl acetate)-based floating tablets with membrane controlled drug delivery. Propranolol HCl containing tablets with Kollidon SR as an excipient for direct compression and different Kollicoat SR 30 D/Kollicoat IR coats varying from 10 to 20mg polymer/cm2 were investigated regarding drug release in 0.1N HCl. Furthermore, the onset of floating, the floating duration and the floating strength of the device were determined. In addition, benchtop MRI studies of selected samples were performed. Coated tablets with 10mg polymer/cm2 SR/IR, 8.5:1.5 coat exhibited the shortest lag times prior to drug release and floating onset, the fastest increase in and highest maximum values of floating strength. The drug release was delayed efficiently within a time interval of 24 h by showing linear drug release characteristics. Poly(vinyl acetate) proved to be an appropriate excipient to ensure safe and reliable drug release. Floating strength measurements offered the possibility to quantify the floating ability of the developed systems and thus to compare different formulations more efficiently. Benchtop MRI studies allowed a deeper insight into drug release and floating mechanisms noninvasively and continuously.

Experimental study of void formation during aluminum solidification in reduced gravity. Ph.D. Thesis - Toledo Univ.

NASA Technical Reports Server (NTRS)

Chiaramonte, Francis Paul, III

1993-01-01

Void formation due to volumetric shrinkage and liquid/vapor reorientation during aluminum solidification was observed in real time by using a radiographic viewing system in normal and reduced gravity. An end-chill directional solidification furnace with water quench was designed and constructed to solidify aluminum samples during the approximately 16 sec of reduced gravity (+/-0.02g) achieved by flying an aircraft through a parabolic trajectory. In the first series of tests the aluminum was contained in a vacuum sealed, pyrolytic boron nitride crucible. An ullage space was present during each test. Void formation was recorded for two cases: a nonwetting system, and a wetting system where wetting occurred between the aluminum and the crucible lid. The void formation in the nonwetting case was similar in normal and reduced gravity, with a single vapor cavity forming at the top of the crucible. In the wetting case during reduced gravity surface tension caused two voids to form in the top corners of the crucible, but during normal gravity only one large void formed across the top. In the second series of tests the aluminum was contained in a pyrolytic boron nitride crucible that was placed in a stainless steel container and sealed in an environment of argon plus 4 percent hydrogen. An ullage space was present during each test. Void formation was recorded for two cases: a nonwetting system, and a wetting system where wetting occurred between the aluminum and one side wall and the lid. The void for nation in the nonwetting case was similar in normal and reduced gravity, with a single vapor cavity forming at the top of the crucible, although the meniscus became more convex in reduced gravity. In the wetting case the aluminum did not climb up the corners in 1g, and one large symmetric void resulted at the top when the aluminum had solidified. In the wetting case during reduced gravity the molten aluminum was drawn up the wetted wall and partially across the lid by a capillary underpressure; however, on the nonwetting wall the aluminum moved down. One void resulted along the nonwetting side of the container continuing to the top on the same side.

Semisynthetic Enzymes by Protein-Peptide Site-Directed Covalent Conjugation: Methods and Applications.

PubMed

Palomo, Jose M

2017-01-01

This chapter describes the rational design and synthesis of semisynthetic lipases by site-directed incorporation of tailor-made peptides on the lipase-lid site to improve its activity, specificity, and enantioselectivity in specific biotransformations. Cysteine was genetically introduced at a particular point of the oligopeptide lid of the enzyme, and cysteine-containing peptides, complementary to the amino acid sequence on the lid site of Geobacillus thermocatenulatus lipase (BTL), were covalently attached on the lid of two different cysteine-BTL variants based on a fast thiol-disulfide exchange ligation followed by desulfurization. The BTL variants were initially immobilized on solid support to introduce the advantages of solid-state chemistry, such as quantitative transformations, easy purification, and recyclability. In the two different immobilized variants BTL-A193C and BTL-L230C, the cysteine was then activated with 2-dipyridyldisulfide to help the disulfide exchange with the peptide, generating the semisynthetic enzyme in high yield. Excellent results of improvement of activity and selectivity were obtained. For example, the peptide-BTL conjugate (at position 193) was 40-fold more active than the corresponding unmodified enzyme for the hydrolysis of per-acetylated thymidine at pH 5, or fourfold in the desymmetrization of dimethyl-3-phenylglutarate at pH 7. The new enzyme also exhibited excellent enantioselectivity in the desymmetrization reaction with enantiomeric excess (ee) of >99% when compared to that of the unmodified enzyme (ee=78%). © 2017 Elsevier Inc. All rights reserved.

Tessier No. 3 and No. 4 clefts: Sequential treatment in infancy by pre-surgical orthopedic skeletal contraction, comprehensive reconstruction, and novel surgical lengthening of the ala base-canthal distance.

PubMed

Spolyar, John L; Hnatiuk, Mark; Shaheen, Kenneth W; Mertz, Jennifer K; Handler, Lawrence F; Jarial, Ravinder; Roldán, J Camilo

2015-09-01

Repair of facial clefts implies wide tissue mobilization with multi-stage surgical treatment. Authors propose pre-surgical orthopedic correction for naso-oro-ocular clefts and a novel surgical option for Tessier No. 3 cleft. Two male infants, a Tessier No. 3 cleft (age 7 months) and another Tessier No. 4 (age 3 months), were treated with a modified orthopedic Latham device with additional septo-premaxillary molding and observed to age four years. Tessier No. 3 orthopedic measurements were obtained by image corrected cephalometric analysis. Subsequent repair included tissue expansion on Tessier No. 4 and naso-frontal Rieger flap combined with myocutaneous upper lid flap on Tessier No. 3. Orthopedic movements ranged from 18.5 mm in bi-planar to 33 mm in oblique analyses. Tissue margins became aligned with platform normalization. Tissue expansion on Tessier No. 4 improved distances from ala base-lower lid and subalar base-lip. The naso-frontal flap combined with myocutaneous upper lid flap on Tessier No. 3 had similar achievement, but also sufficiently lengthened ala base-canthal distance. Repairs were facilitated by pre-surgical orthopedic correction. The naso-frontal flap combined with an upper lid myocutaneous flap seems viable as a single-stage option to lengthen ala base-canthal distance to advance repair achievement in unilateral Tessier No. 3. Copyright © 2015 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.