Stress-strain analysis of jejunal contractility in response to flow and ramp distension in type 2 diabetic GK rats: effect of carbachol stimulation.

PubMed

Zhao, Jingbo; Chen, Pengmin; Gregersen, Hans

2013-09-27

Investigation of intestinal motility in a genetic model of GK rats abandons the possible neurotoxic effect of streptozotocin in streptozotocin-induced diabetic model. Seven GK male rats (GK group) and nine normal Wistar rats (Normal group) were used in the study. The motility experiments were carried out in an organ bath containing physiological Krebs solution. Before and after 10(-5)M carbachol application, the pressure and diameter changes of jejunum were obtained in relation to (1) basic contraction, (2) flow-induced contraction with different outlet resistance pressures and (3) contractions induced by ramp distension. The frequency and amplitude of contractions were analyzed from pressure-diameter curves. Distension-induced contraction thresholds and maximum contraction amplitude of basic and flow-induced contractions were calculated in terms of stress and strain. (1) The contraction amplitude increased to the peak value in less than 10s after adding carbachol. More than two peaks were observed in the GK group. (2) Carbachol decreased the pressure and stress threshold and Young's modulus in the GK group (P<0.01). (3) Carbachol increased the maximum pressure and stress of flow-induced contractions at most outlet pressure levels in both two groups (P<0.001). Furthermore, the flow-induced contractions were significantly bigger at low outlet pressure levels in GK group (P<0.05 and P<0.01). (4) The contraction frequency, the strain threshold and the maximum contraction strain did not differ between the two groups (P>0.05) and between before and after carbachol application (P>0.05). In GK diabetic rats, the jejunal contractility was hypersensitive to flow and distension stimulation after carbachol application. Copyright © 2013 Elsevier Ltd. All rights reserved.

Lens or Prism? Patent Citations as a Measure of Knowledge Flows from Public Research

PubMed Central

Roach, Michael; Cohen, Wesley M.

2013-01-01

This paper assesses the validity and accuracy of firms’ backward patent citations as a measure of knowledge flows from public research by employing a newly constructed dataset that matches patents to survey data at the level of the R&D lab. Using survey-based measures of the dimensions of knowledge flows, we identify sources of systematic measurement error associated with backward citations to both patent and nonpatent references. We find that patent citations reflect the codified knowledge flows from public research, but they appear to miss knowledge flows that are more private and contract-based in nature, as well as those used in firm basic research. We also find that firms’ patenting and citing strategies affect patent citations, making citations less indicative of knowledge flows. In addition, an illustrative analysis examining the magnitude and direction of measurement error bias suggests that measuring knowledge flows with patent citations can lead to substantial underestimation of the effect of public research on firms’ innovative performance. Throughout our analyses we find that nonpatent references (e.g., journals, conferences, etc.), not the more commonly used patent references, are a better measure of knowledge originating from public research. PMID:24470690

Genetics Home Reference: paramyotonia congenita

MedlinePlus

... tense (contract) and relax in a coordinated way. Muscle contractions are triggered by the flow of positively charged ... resulting increase in ion flow interferes with normal muscle contraction and relaxation, leading to episodes of muscle stiffness ...

Contraction rate, flow modification and bed layering impact on scour at the elliptical guide banks

NASA Astrophysics Data System (ADS)

Gjunsburgs, B.; Jaudzems, G.; Bizane, M.; Bulankina, V.

2017-10-01

Flow contraction by the bridge crossing structures, intakes, embankments, piers, abutments and guide banks leads to general scour and the local scour in the vicinity of the structures. Local scour is depending on flow, river bed and structures parameters and correct understanding of the impact of each parameter can reduce failure possibility of the structures. The paper explores hydraulic contraction, the discharge redistribution between channel and floodplain during the flood, local flow modification and river bed layering on depth, width and volume of scour hole near the elliptical guide banks on low-land rivers. Experiments in a flume, our method for scour calculation and computer modelling results confirm a considerable impact of the contraction rate of the flow, the discharge redistribution between channel and floodplain, the local velocity, backwater and river bed layering on the depth, width, and volume of scour hole in steady and unsteady flow, under clear water condition. With increase of the contraction rate of the flow, the discharge redistribution between channel and floodplain, the local velocity, backwater values, the scour depth increases. At the same contraction rate, but at a different Fr number, the scour depth is different: with increase in the Fr number, the local velocity, backwater, scour depth, width, and volume is increasing. Acceptance of the geometrical contraction of the flow, approach velocity and top sand layer of the river bed for scour depth calculation as accepted now, may be the reason of the structures failure and human life losses.

Active Flow Control Activities at NASA Langley

NASA Technical Reports Server (NTRS)

Anders, Scott G.; Sellers, William L., III; Washburn, Anthony E.

2004-01-01

NASA Langley continues to aggressively investigate the potential advantages of active flow control over more traditional aerodynamic techniques. This paper provides an update to a previous paper and describes both the progress in the various research areas and the significant changes in the NASA research programs. The goals of the topics presented are focused on advancing the state of knowledge and understanding of controllable fundamental mechanisms in fluids as well as to address engineering challenges. An organizational view of current research activities at NASA Langley in active flow control as supported by several projects is presented. On-center research as well as NASA Langley funded contracts and grants are discussed at a relatively high level. The products of this research are to be demonstrated either in bench-top experiments, wind-tunnel investigations, or in flight as part of the fundamental NASA R&D program and then transferred to more applied research programs within NASA, DOD, and U.S. industry.

Regulation of increased blood flow (hyperemia) to muscles during exercise: a hierarchy of competing physiological needs.

PubMed

Joyner, Michael J; Casey, Darren P

2015-04-01

This review focuses on how blood flow to contracting skeletal muscles is regulated during exercise in humans. The idea is that blood flow to the contracting muscles links oxygen in the atmosphere with the contracting muscles where it is consumed. In this context, we take a top down approach and review the basics of oxygen consumption at rest and during exercise in humans, how these values change with training, and the systemic hemodynamic adaptations that support them. We highlight the very high muscle blood flow responses to exercise discovered in the 1980s. We also discuss the vasodilating factors in the contracting muscles responsible for these very high flows. Finally, the competition between demand for blood flow by contracting muscles and maximum systemic cardiac output is discussed as a potential challenge to blood pressure regulation during heavy large muscle mass or whole body exercise in humans. At this time, no one dominant dilator mechanism accounts for exercise hyperemia. Additionally, complex interactions between the sympathetic nervous system and the microcirculation facilitate high levels of systemic oxygen extraction and permit just enough sympathetic control of blood flow to contracting muscles to regulate blood pressure during large muscle mass exercise in humans. Copyright © 2015 the American Physiological Society.

Regulation of Increased Blood Flow (Hyperemia) to Muscles During Exercise: A Hierarchy of Competing Physiological Needs

PubMed Central

Joyner, Michael J.; Casey, Darren P.

2015-01-01

This review focuses on how blood flow to contracting skeletal muscles is regulated during exercise in humans. The idea is that blood flow to the contracting muscles links oxygen in the atmosphere with the contracting muscles where it is consumed. In this context, we take a top down approach and review the basics of oxygen consumption at rest and during exercise in humans, how these values change with training, and the systemic hemodynamic adaptations that support them. We highlight the very high muscle blood flow responses to exercise discovered in the 1980s. We also discuss the vasodilating factors in the contracting muscles responsible for these very high flows. Finally, the competition between demand for blood flow by contracting muscles and maximum systemic cardiac output is discussed as a potential challenge to blood pressure regulation during heavy large muscle mass or whole body exercise in humans. At this time, no one dominant dilator mechanism accounts for exercise hyperemia. Additionally, complex interactions between the sympathetic nervous system and the microcirculation facilitate high levels of systemic oxygen extraction and permit just enough sympathetic control of blood flow to contracting muscles to regulate blood pressure during large muscle mass exercise in humans. PMID:25834232

Chemical laser exhaust pipe design research

NASA Astrophysics Data System (ADS)

Sun, Yunqiang; Huang, Zhilong; Chen, Zhiqiang; Ren, Zebin; Guo, Longde

2016-10-01

In order to weaken the chemical laser exhaust gas influence of the optical transmission, a vent pipe is advised to emissions gas to the outside of the optical transmission area. Based on a variety of exhaust pipe design, a flow field characteristic of the pipe is carried out by numerical simulation and analysis in detail. The research results show that for uniform deflating exhaust pipe, although the pipeline structure is cyclical and convenient for engineering implementation, but there is a phenomenon of air reflows at the pipeline entrance slit which can be deduced from the numerical simulation results. So, this type of pipeline structure does not guarantee seal. For the design scheme of putting the pipeline contract part at the end of the exhaust pipe, or using the method of local area or tail contraction, numerical simulation results show that backflow phenomenon still exists at the pipeline entrance slit. Preliminary analysis indicates that the contraction of pipe would result in higher static pressure near the wall for the low speed flow field, so as to produce counter pressure gradient at the entrance slit. In order to eliminate backflow phenomenon at the pipe entrance slit, concerned with the pipeline type of radial size increase gradually along the flow, flow field property in the pipe is analyzed in detail by numerical simulation methods. Numerical simulation results indicate that there is not reflow phenomenon at entrance slit of the dilated duct. However the cold air inhaled in the slit which makes the temperature of the channel wall is lower than the center temperature. Therefore, this kind of pipeline structure can not only prevent the leak of the gas, but also reduce the wall temperature. In addition, compared with the straight pipe connection way, dilated pipe structure also has periodic structure, which can facilitate system integration installation.

Observations of Gas-Liquid Flows Through Contractions in Microgravity

NASA Technical Reports Server (NTRS)

McQuillen, John

1996-01-01

Tests were conducted for an air-water flow through two sudden contractions aboard the NASA DC-9 low gravity aircraft. Flow rate, residual accelerations, void fraction, film thickness, and pressure drop data were recorded and flow visualization at 250 images per second were recorded. Some preliminary results based on the flow visualization data are presented for bubbly, slug and annular flow.

Blood clots are rapidly assembled hemodynamic sensors: flow arrest triggers intraluminal thrombus contraction.

PubMed

Muthard, Ryan W; Diamond, Scott L

2012-12-01

Blood clots form under flow during intravascular thrombosis or vessel leakage. Prevailing hemodynamics influence thrombus structure and may regulate contraction processes. A microfluidic device capable of flowing human blood over a side channel plugged with collagen (± tissue factor) was used to measure thrombus permeability (κ) and contraction at controlled transthrombus pressure drops. The collagen (κ(collagen)=1.98 × 10(-11) cm(2)) supported formation of a 20-µm thick platelet layer, which unexpectedly underwent massive platelet retraction on flow arrest. This contraction resulted in a 5.34-fold increase in permeability because of collagen restructuring. Without stopping flow, platelet deposits (no fibrin) had a permeability of κ(platelet)=5.45 × 10(-14) cm(2) and platelet-fibrin thrombi had κ(thrombus)=2.71 × 10(-14) cm(2) for ΔP=20.7 to 23.4 mm Hg, the first ever measurements for clots formed under arterial flow (1130 s(-1) wall shear rate). Platelet sensing of flow cessation triggered a 4.6- to 6.5-fold (n=3, P<0.05) increase in contraction rate, which was also observed in a rigid, impermeable parallel-plate microfluidic device. This triggered contraction was blocked by the myosin IIA inhibitor blebbistatin and by inhibitors of thromboxane A2 (TXA(2)) and ADP signaling. In addition, flow arrest triggered platelet intracellular calcium mobilization, which was blocked by TXA(2)/ADP inhibitors. As clots become occlusive or blood pools following vessel leakage, the flow diminishes, consequently allowing full platelet retraction. Flow dilution of ADP and thromboxane regulates platelet contractility with prevailing hemodynamics, a newly defined flow-sensing mechanism to regulate clot function.

Blood clots are rapidly assembled hemodynamic sensors: Flow arrest triggers intraluminal thrombus contraction

PubMed Central

Muthard, Ryan W.; Diamond, Scott L.

2012-01-01

Objective Blood clots form under flow during intravascular thrombosis or vessel leakage. Prevailing hemodynamics influence thrombus structure and may regulate contraction processes. A microfluidic device capable of flowing human blood over a side channel plugged with collagen (± tissue factor) was used to measure thrombus permeability (κ) and contraction at controlled transthrombus pressure drops. Methods and Results The collagen (κcollagen = 1.98 × 10−11 cm2) supported formation of a 20-μm thick platelet layer, which unexpectedly underwent massive platelet retraction upon flow arrest. This contraction resulted in a 5.34-fold increase in permeability due to collagen restructuring. Without stopping flow, platelet deposits (no fibrin) had a permeability of κplatelet = 5.45 × 10−14 cm2 and platelet-fibrin thrombi had κthrombus = 2.71 × 10−14 cm2 for ΔP = 20.7 to 23.4 mm-Hg, the first ever measurements for clots formed under arterial flow (1130 s−1 wall shear rate). Platelet sensing of flow cessation triggered a 4.6 to 6.5-fold (n=3, P<0.05) increase in contraction rate, which was also observed in a rigid, impermeable parallel-plate microfluidic device. This triggered contraction was blocked by the myosin IIA inhibitor blebbistatin and by inhibitors of thromboxane (TXA2) and ADP signaling. In addition, flow arrest triggered platelet intracellular calcium mobilization, which was blocked by TXA2/ADP inhibitors. As clots become occlusive or vessels rupture, flow around developed clots diminishes facilitating full platelet retraction and hemostasis. Conclusion Flow dilution of ADP and thromboxane regulates platelet contractility with prevailing hemodynamics, a newly defined flow sensing mechanism to regulate clot function. PMID:23087356

A rotating hot-wire technique for spatial sampling of disturbed and manipulated duct flows

NASA Technical Reports Server (NTRS)

Wark, C. E.; Nagib, H. M.; Jennings, M. J.

1990-01-01

A duct flow spatial sampling technique, in which an X-wire probe is rotated about the center of a cylindrical test section at a radius equal to one-half that of the test section in order to furnish nearly instantaneous multipoint measurements of the streamwise and azimuthal components, is presently evaluated in view of the control of flow disturbances downstream of various open inlet contractions. The effectiveness of a particular contraction in controlling ingested flow disturbances was ascertained by artificially introducing disturbances upstream of the contractions; control effectiveness if found to be strongly dependent on inlet contraction, with consequences for the reduction of passing-blade frequency noise during gas turbine engine ground testing.

Flow caused by the stalk contraction of Vorticella

NASA Astrophysics Data System (ADS)

Ryu, Sangjin; Chung, Eun-Gul; Admiraal, David

2016-11-01

Vorticella is a stalked protozoan, and its ultrafast stalk contraction moves the spherically-shrunken cell body (zooid) and thus causes surrounding water to flow. Because the fluid dynamics of this water flow is important for understanding the motility of Vorticella, we investigated the flow based on various fluid dynamics approaches. To find why Vorticella contracts its stalk, we propose a hypothesis that the protist utilizes the contraction-induced water flow to augment transport of food particles. This hypothesis was investigated using a computational fluid dynamics (CFD) model, which was validated with an experimental scale model of Vorticella. The CFD model enabled calculating the motion of particles around Vorticella and thus quantifying the transport effect of the stalk contraction. Also, we have developed a hydrodynamic drag model for easier estimation of Vorticella's contractility without using the CFD model. Because the contractile force of the stalk equals the drag on the moving zooid, the model enabled evaluating the contractile force and energetics of Vorticella based on its contraction speed. Analyses using the drag model show that the stalk contractility of Vorticella depends on the stalk length. This study was supported by UNL Layman Seed Grant and Nebraska EPSCoR First Award Grant.

The 1992 Seals Flow Code Development Workshop

NASA Technical Reports Server (NTRS)

Liang, Anita D.; Hendricks, Robert C.

1993-01-01

A two-day meeting was conducted at the NASA Lewis Research Center on August 5 and 6, 1992, to inform the technical community of the progress of NASA Contract NAS3-26544. This contract was established in 1990 to develop industrial and CFD codes for the design and analysis of seals. Codes were demonstrated and disseminated to the user community for evaluation. The peer review panel which was formed in 1991 provided recommendations on this effort. The technical community presented results of their activities in the area of seals, with particular emphasis on brush seal systems.

Hemodynamics of a functional centrifugal-flow total artificial heart with functional atrial contraction in goats.

PubMed

Shiga, Takuya; Shiraishi, Yasuyuki; Sano, Kyosuke; Taira, Yasunori; Tsuboko, Yusuke; Yamada, Akihiro; Miura, Hidekazu; Katahira, Shintaro; Akiyama, Masatoshi; Saiki, Yoshikatsu; Yambe, Tomoyuki

2016-03-01

Implantation of a total artificial heart (TAH) is one of the therapeutic options for the treatment of patients with end-stage biventricular heart failure. There is no report on the hemodynamics of the functional centrifugal-flow TAH with functional atrial contraction (fCFTAH). We evaluated the effects of pulsatile flow by atrial contraction in acute animal models. The goats received fCFTAH that we created from two centrifugal-flow ventricular assist devices. Some hemodynamic parameters maintained acceptable levels: heart rate 115.5 ± 26.3 bpm, aortic pressure 83.5 ± 10.1 mmHg, left atrial pressure 18.0 ± 5.9 mmHg, pulmonary pressure 28.5 ± 9.7 mmHg, right atrial pressure 13.6 ± 5.2 mmHg, pump flow 4.0 ± 1.1 L/min (left) 3.9 ± 1.1 L/min (right), and cardiac index 2.13 ± 0.14 L/min/m(2). fCFTAH with atrial contraction was able to maintain the TAH circulation by forming a pulsatile flow in acute animal experiments. Taking the left and right flow rate balance using the low internal pressure loss of the VAD pumps may be easier than by other pumps having considerable internal pressure loss. We showed that the remnant atrial contraction effected the flow rate change of the centrifugal pump, and the atrial contraction waves reflected the heart rate. These results indicate that remnant atria had the possibility to preserve autonomic function in fCFTAH. We may control fCFTAH by reflecting the autonomic function, which is estimated with the flow rate change of the centrifugal pump.

Treatment with a nitric oxide-donating NSAID alleviates functional muscle ischemia in the mouse model of Duchenne muscular dystrophy.

PubMed

Thomas, Gail D; Ye, Jianfeng; De Nardi, Claudio; Monopoli, Angela; Ongini, Ennio; Victor, Ronald G

2012-01-01

In patients with Duchenne muscular dystrophy (DMD) and the standard mdx mouse model of DMD, dystrophin deficiency causes loss of neuronal nitric oxide synthase (nNOSμ) from the sarcolemma, producing functional ischemia when the muscles are exercised. We asked if functional muscle ischemia would be eliminated and normal blood flow regulation restored by treatment with an exogenous nitric oxide (NO)-donating drug. Beginning at 8 weeks of age, mdx mice were fed a standard diet supplemented with 1% soybean oil alone or in combination with a low (15 mg/kg) or high (45 mg/kg) dose of HCT 1026, a NO-donating nonsteroidal anti-inflammatory agent which has previously been shown to slow disease progression in the mdx model. After 1 month of treatment, vasoconstrictor responses to intra-arterial norepinephrine (NE) were compared in resting and contracting hindlimbs. In untreated mdx mice, the usual effect of muscle contraction to attenuate NE-mediated vasoconstriction was impaired, resulting in functional ischemia: NE evoked similar decreases in femoral blood flow velocity and femoral vascular conductance (FVC) in the contracting compared to resting hindlimbs (ΔFVC contraction/ΔFVC rest=0.88 ± 0.03). NE-induced functional ischemia was unaffected by low dose HCT 1026 (ΔFVC ratio=0.92 ± 0.04; P>0.05 vs untreated), but was alleviated by the high dose of the drug (ΔFVC ratio=0.22 ± 0.03; P<0.05 vs untreated or low dose). The beneficial effect of high dose HCT 1026 was maintained with treatment up to 3 months. The effect of the NO-donating drug HCT 1026 to normalize blood flow regulation in contracting mdx mouse hindlimb muscles suggests a putative novel treatment for DMD. Further translational research is warranted.

Flow of a Gas Turbine Engine Low-Pressure Subsystem Simulated

NASA Technical Reports Server (NTRS)

Veres, Joseph P.

1997-01-01

The NASA Lewis Research Center is managing a task to numerically simulate overnight, on a parallel computing testbed, the aerodynamic flow in the complete low-pressure subsystem (LPS) of a gas turbine engine. The model solves the three-dimensional Navier- Stokes flow equations through all the components within the LPS, as well as the external flow around the engine nacelle. The LPS modeling task is being performed by Allison Engine Company under the Small Engine Technology contract. The large computer simulation was evaluated on networked computer systems using 8, 16, and 32 processors, with the parallel computing efficiency reaching 75 percent when 16 processors were used.

Injection of Nucleate-Boiling Slug Flows into a Heat Exchange Chamber in Microgravity

DTIC Science & Technology

2015-06-01

Casademunt UNIVERSITAT DE BARCELONA CALLE GRAN VIA DE LES CORTS CATALANES 585 BARCELONA 08007 SPAIN EOARD GRANT #FA8655-12-1- 2060 ...slug flows into a heat exchange chamber in microgravity 5a. CONTRACT NUMBER 5b. GRANT NUMBER FA8655-12-1- 2060 5c. PROGRAM ELEMENT NUMBER...Scientific Research (AFOSR) FINAL REPORT EOARD Grant : FA8655-12-1- 2060 PERIOD: 20 March 2012 – 19 March 2015 PROJECT TITLE

1996 Coolant Flow Management Workshop

NASA Technical Reports Server (NTRS)

Hippensteele, Steven A. (Editor)

1997-01-01

The following compilation of documents includes a list of the 66 attendees, a copy of the viewgraphs presented, and a summary of the discussions held after each session at the 1996 Coolant Flow Management Workshop held at the Ohio Aerospace Institute, adjacent to the NASA Lewis Research Center, Cleveland, Ohio on December 12-13, 1996. The workshop was organized by H. Joseph Gladden and Steven A. Hippensteele of NASA Lewis Research Center. Participants in this workshop included Coolant Flow Management team members from NASA Lewis, their support service contractors, the turbine engine companies, and the universities. The participants were involved with research projects, contracts and grants relating to: (1) details of turbine internal passages, (2) computational film cooling capabilities, and (3) the effects of heat transfer on both sides. The purpose of the workshop was to assemble the team members, along with others who work in gas turbine cooling research, to discuss needed research and recommend approaches that can be incorporated into the Center's Coolant Flow Management program. The workshop was divided into three sessions: (1) Internal Coolant Passage Presentations, (2) Film Cooling Presentations, and (3) Coolant Flow Integration and Optimization. Following each session there was a group discussion period.

Flow Quality Studies of the NASA Glenn Research Center Icing Research Tunnel Circuit (1995 Tests)

NASA Technical Reports Server (NTRS)

Arrington, E. Allen; Kee-Bowling, Bonnie A.; Gonsalez, Jose C.

2000-01-01

The purpose of conducting the flow-field surveys described in this report was to more fully document the flow quality in several areas of the tunnel circuit in the NASA Glenn Research Center Icing Research Tunnel. The results from these surveys provide insight into areas of the tunnel that were known to exhibit poor flow quality characteristics and provide data that will be useful to the design of flow quality improvements and a new heat exchanger for the facility. An instrumented traversing mechanism was used to survey the flow field at several large cross sections of the tunnel loop over the entire speed range of the facility. Flow-field data were collected at five stations in the tunnel loop, including downstream of the fan drive motor housing, upstream and downstream of the heat exchanger, and upstream and downstream of the spraybars located in the settling chamber upstream of the test section. The data collected during these surveys greatly expanded the data base describing the flow quality in each of these areas. The new data matched closely the flow quality trends recorded from earlier tests. Data collected downstream of the heat exchanger and in the settling chamber showed how the configuration of the folded heat exchanger affected the pressure, velocity, and flow angle distributions in these areas. Smoke flow visualization was also used to qualitatively study the flow field in an area downstream of the drive fan and in the settling chamber/contraction section.

Stress-strain analysis of contractility in the ileum in response to flow and ramp distension in streptozotocin-induced diabetic rats--association with advanced glycation end product formation.

PubMed

Zhao, Jingbo; Chen, Pengmin; Gregersen, Hans

2015-04-13

This study compared the ileal contractility and analyzed the association between contractility with advanced glycation end product (AGE) formation in normal and streptozotocin (STZ)-induced diabetic rats. Nine STZ-induced diabetic rats (Diabetes group) and 9 normal rats (Normal group) were used. The motility experiments were carried out on ileums in organ baths containing physiological Krebs solution. Ileal pressure and diameter changes were obtained from basic, flow-induced and ramp distension-induced contractions. The frequency and amplitude of contractions were analyzed from pressure-diameter curves. Distension-induced contraction thresholds and maximum contraction amplitude of basic and flow-induced contractions were calculated in terms of stress and strain. AGE and its receptor (RAGE) in the layers were detected by immunohistochemistry staining. The maximum stress of flow-induced contractions was lowest in the Diabetes Group (P<0.05). During ramp distension, the pressure and stress thresholds and Young's modulus to induce phasic contraction were lowest in the Diabetes Group (P<0.05 and P<0.01). AGE and RAGE expressions in the different ileum layers were highest in the Diabetes group. The contraction pressure and stress thresholds were significantly associated with AGE expression in the muscle layer and RAGE expression in mucosa epithelium and neurons. The diabetic intestine was hypersensitive to distension for contraction induction. However, the contraction force produced by smooth muscle was lowest in diabetic rats. Increased AGE/RAGE expression was associated with the contractility changes in diabetic rats. Copyright © 2015 Elsevier Ltd. All rights reserved.

FloWave.US: validated, open-source, and flexible software for ultrasound blood flow analysis.

PubMed

Coolbaugh, Crystal L; Bush, Emily C; Caskey, Charles F; Damon, Bruce M; Towse, Theodore F

2016-10-01

Automated software improves the accuracy and reliability of blood velocity, vessel diameter, blood flow, and shear rate ultrasound measurements, but existing software offers limited flexibility to customize and validate analyses. We developed FloWave.US-open-source software to automate ultrasound blood flow analysis-and demonstrated the validity of its blood velocity (aggregate relative error, 4.32%) and vessel diameter (0.31%) measures with a skeletal muscle ultrasound flow phantom. Compared with a commercial, manual analysis software program, FloWave.US produced equivalent in vivo cardiac cycle time-averaged mean (TAMean) velocities at rest and following a 10-s muscle contraction (mean bias <1 pixel for both conditions). Automated analysis of ultrasound blood flow data was 9.8 times faster than the manual method. Finally, a case study of a lower extremity muscle contraction experiment highlighted the ability of FloWave.US to measure small fluctuations in TAMean velocity, vessel diameter, and mean blood flow at specific time points in the cardiac cycle. In summary, the collective features of our newly designed software-accuracy, reliability, reduced processing time, cost-effectiveness, and flexibility-offer advantages over existing proprietary options. Further, public distribution of FloWave.US allows researchers to easily access and customize code to adapt ultrasound blood flow analysis to a variety of vascular physiology applications. Copyright © 2016 the American Physiological Society.

Advancement and Application of Multi-Phase CFD Modeling to High Speed Supercavitating Flows

DTIC Science & Technology

2013-08-13

5a. CONTRACT NUMBER 5b. GRANT NUMBER N00014-09-1-0042 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Jules W. Lindau and Michael P. Kinzel 5d. PROJECT...REPORT U b. ABSTRACT U c. THIS PAGE U 17. LIMITATION OF ABSTRACT U 18. NUMBER OF PAGES 29 19a. NAME OF RESPONSIBLE PERSON Jules W. Lindau...Application of Multi-Phase CFD Modeling to High Speed Supercavitating Flows Michael P. Kinzel Jules W. Lindau Penn State University Applied Research

Local nitric oxide synthase inhibition reduces skeletal muscle glucose uptake but not capillary blood flow during in situ muscle contraction in rats.

PubMed

Ross, Renee M; Wadley, Glenn D; Clark, Michael G; Rattigan, Stephen; McConell, Glenn K

2007-12-01

We have previously shown in humans that local infusion of a nitric oxide synthase (NOS) inhibitor into the femoral artery attenuates the increase in leg glucose uptake during exercise without influencing total leg blood flow. However, rodent studies examining the effect of NOS inhibition on contraction-stimulated skeletal muscle glucose uptake have yielded contradictory results. This study examined the effect of local infusion of an NOS inhibitor on skeletal muscle glucose uptake (2-deoxyglucose) and capillary blood flow (contrast-enhanced ultrasound) during in situ contractions in rats. Male hooded Wistar rats were anesthetized and one hindleg electrically stimulated to contract (2 Hz, 0.1 ms) for 30 min while the other leg rested. After 10 min, the NOS inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME) (arterial concentration of 5 micromol/l) or saline was infused into the epigastric artery of the contracting leg. Local NOS inhibition had no effect on blood pressure, heart rate, or muscle contraction force. Contractions increased (P < 0.05) skeletal muscle NOS activity, and this was prevented by L-NAME infusion. NOS inhibition caused a modest significant (P < 0.05) attenuation of the increase in femoral blood flow during contractions, but importantly there was no effect on capillary recruitment. NOS inhibition attenuated (P < 0.05) the increase in contraction-stimulated skeletal muscle glucose uptake by approximately 35%, without affecting AMP-activated protein kinase (AMPK) activation. NOS inhibition attenuated increases in skeletal muscle glucose uptake during contraction without influencing capillary recruitment, suggesting that NO is critical for part of the normal increase in skeletal muscle fiber glucose uptake during contraction.

Actin retrograde flow and actomyosin II arc contraction drive receptor cluster dynamics at the immunological synapse in Jurkat T cells

PubMed Central

Yi, Jason; Wu, Xufeng S.; Crites, Travis; Hammer, John A.

2012-01-01

Actin retrograde flow and actomyosin II contraction have both been implicated in the inward movement of T cell receptor (TCR) microclusters and immunological synapse formation, but no study has integrated and quantified their relative contributions. Using Jurkat T cells expressing fluorescent myosin IIA heavy chain and F-tractin—a novel reporter for F-actin—we now provide direct evidence that the distal supramolecular activation cluster (dSMAC) and peripheral supramolecular activation cluster (pSMAC) correspond to lamellipodial (LP) and lamellar (LM) actin networks, respectively, as hypothesized previously. Our images reveal concentric and contracting actomyosin II arcs/rings at the LM/pSMAC. Moreover, the speeds of centripetally moving TCR microclusters correspond very closely to the rates of actin retrograde flow in the LP/dSMAC and actomyosin II arc contraction in the LM/pSMAC. Using cytochalasin D and jasplakinolide to selectively inhibit actin retrograde flow in the LP/dSMAC and blebbistatin to selectively inhibit actomyosin II arc contraction in the LM/pSMAC, we demonstrate that both forces are required for centripetal TCR microcluster transport. Finally, we show that leukocyte function–associated antigen 1 clusters accumulate over time at the inner aspect of the LM/pSMAC and that this accumulation depends on actomyosin II contraction. Thus actin retrograde flow and actomyosin II arc contraction coordinately drive receptor cluster dynamics at the immunological synapse. PMID:22219382

Metabolic adaptations to repeated periods of contraction with reduced blood flow in canine skeletal muscle

PubMed Central

MacInnes, Alan; Timmons, James A

2005-01-01

Background Patients suffering from Intermittent Claudication (IC) experience repeated periods of muscle contraction with low blood flow, throughout the day and this may contribute to the hypothesised skeletal muscle abnormalities. However, no study has evaluated the consequences of intermittent contraction with low blood flow on skeletal muscle tissue. Our aim was to generate this basic physiological data, determining the 'normal' response of healthy skeletal muscle tissue. We specifically proposed that the metabolic responses to contraction would be modified under such circumstances, revealing endogenous strategies engaged to protect the muscle adenine nucleotide pool. Utilizing a canine gracilis model (n = 9), the muscle was stimulated to contract (5 Hz) for three 10 min periods (separated by 10 min rest) under low blood flow conditions (80% reduced), followed by 1 hr recovery and then a fourth period of 10 min stimulation. Muscle biopsies were obtained prior to and following the first and fourth contraction periods. Direct arterio-venous sampling allowed for the calculation of muscle metabolite efflux and oxygen consumption. Results During the first period of contraction, [ATP] was reduced by ~30%. During this period there was also a 10 fold increase in muscle lactate concentration and a substantial increase in muscle lactate and ammonia efflux. Subsequently, lactate efflux was similar during the first three periods, while ammonia efflux was reduced by the third period. Following 1 hr recovery, muscle lactate and phosphocreatine concentrations had returned to resting values, while muscle [ATP] remained 20% lower. During the fourth contraction period no ammonia efflux or change in muscle ATP content occured. Despite such contrasting metabolic responses, muscle tension and oxygen consumption were identical during all contraction periods from 3 to 10 min. Conclusion repeated periods of muscle contraction, with low blood flow, results in cessation of muscle ammonia production which is suggestive of a dramatic reduction in flux through AMP deaminase. PMID:16018808

Overview of the Icing and Flow Quality Improvements Program for the NASA Glenn Icing Research Tunnel

NASA Technical Reports Server (NTRS)

Irvine, Thomas B.; Kevdzija, Susan L.; Sheldon, David W.; Spera, David A.

2001-01-01

Major upgrades were made in 1999 to the 6- by 9-Foot (1.8- by 2.7-m) Icing Research Tunnel (IRT) at the NASA Glenn Research Center. These included replacement of the electronic controls for the variable-speed drive motor, replacement of the heat exchanger, complete replacement and enlargement of the leg of the tunnel containing the new heat-exchanger, the addition of flow-expanding and flow-contracting turning vanes upstream and downstream of the heat exchanger, respectively, and the addition of fan outlet guide vanes (OGV's). This paper describes the rationale behind this latest program of IRT upgrades and the program's requirements and goals. An overview is given of the scope of work undertaken by the design and construction contractors, the scale-model IRT (SMIRT) design verification program, the comprehensive reactivation test program initiated upon completion of construction, and the overall management approach followed.

Spatial interaction between tissue pressure and skeletal muscle perfusion during contraction.

PubMed

van Donkelaar, C C; Huyghe, J M; Vankan, W J; Drost, M R

2001-05-01

The vascular waterfall theory attributes decreased muscle perfusion during contraction to increased intramuscular pressure (P(IM)) and concomitant increase in venous resistance. Although P(IM) is distributed during contractions, this theory does not account for heterogeneity. This study hypothesises that pressure heterogeneity could affect the interaction between P(IM) rise and perfusion. Regional tissue perfusion during submaximum (100kPa) tetanic contraction is studied, using a finite element model of perfused contracting skeletal muscle. Capillary flow in muscles with one proximal artery and vein (SIM(1)) and with an additional distal artery and vein (SIM(2)) is compared. Blood flow and pressures at rest and P(IM) during contraction ( approximately 25kPa maximally) are similar between simulations, but capillary flow and venous pressure differ. In SIM(2), venous pressure and capillary flow correspond to P(IM) distribution, whereas capillary flow in SIM(1) is less than 10% of flow in SIM(2), in the muscle half without draining vein. This difference is caused by a high central P(IM), followed by central venous pressure rise, in agreement with the waterfall theory. The high central pressure (SIM(1)), obstructs outflow from the distal veins. Distal venous pressure rises until central blood pressure is reached, although local P(IM) is low. Adding a distal vein (SIM(2)) restores the perfusion. It is concluded that regional effects contribute to the interaction between P(IM) and perfusion during contraction. Unlike stated by the vascular waterfall theory, venous pressure may locally exceed P(IM). Although this can be explained by the principles of this theory, the theory does not include this phenomenon as such.

Contraction driven flow in the extended vein networks of Physarum polycephalum

NASA Astrophysics Data System (ADS)

Alim, Karen; Amselem, Gabriel; Peaudecerf, Francois; Pringle, Anne; Brenner, Michael P.

2011-11-01

The true slime mold Physarum polycephalum is a basal organism that forms an extended network of veins to forage for food. P. polycephalum is renown for its adaptive changes of vein structure and morphology in response to food sources. These rearrangements presumably occur to establish an efficient transport and mixing of resources throughout the networks thus presenting a prototype to design transport networks under the constraints of laminar flow. The physical flows of cytoplasmic fluid enclosed by the veins exhibit an oscillatory flow termed ``shuttle streaming.'' The flow exceed by far the volume required for growth at the margins suggesting that the additional energy cost for generating the flow is spent for efficient and/or targeted redistribution of resources. We show that the viscous shuttle flow is driven by the radial contractions of the veins that accompany the streaming. We present a model for the fluid flow and resource dispersion arising due to radial contractions. The transport and mixing properties of the flow are discussed.

Development of Combined Asymptotic and Numerical Procedures for Transonic and Hypersonic Flows.

DTIC Science & Technology

1996-04-01

11991 thru December 311995 Contract No. F49620-92-C-0006 Prepared for: Air Force Office of Scientific Research, AFOSR/NM Directorate of Mathematical and...MOMOMNO Air Force Office of Scientific Research AGENCY REOT NUMBER AFOSRJNM Directorat of Mathematical and information Sciences Bldg 410 Boiling AFS, DC...128 wind tunnel leading to the generalization of our Transonic Area Rule for Wind Tunnel Wall Interference (TARWI) to test articles of length

Operating The Central Process Systems At Glenn Research Center

NASA Technical Reports Server (NTRS)

Weiler, Carly P.

2004-01-01

As a research facility, the Glenn Research Center (GRC) trusts and expects all the systems, controlling their facilities to run properly and efficiently in order for their research and operations to occur proficiently and on time. While there are many systems necessary for the operations at GRC, one of those most vital systems is the Central Process Systems (CPS). The CPS controls operations used by GRC's wind tunnels, propulsion systems lab, engine components research lab, and compressor, turbine and combustor test cells. Used widely throughout the lab, it operates equipment such as exhausters, chillers, cooling towers, compressors, dehydrators, and other such equipment. Through parameters such as pressure, temperature, speed, flow, etc., it performs its primary operations on the major systems of Electrical Dispatch (ED), Central Air Dispatch (CAD), Central Air Equipment Building (CAEB), and Engine Research Building (ERB). In order for the CPS to continue its operations at Glenn, a new contract must be awarded. Consequently, one of my primary responsibilities was assisting the Source Evaluation Board (SEB) with the process of awarding the recertification contract of the CPS. The job of the SEB was to evaluate the proposals of the contract bidders and then to present their findings to the Source Selecting Official (SSO). Before the evaluations began, the Center Director established the level of the competition. For this contract, the competition was limited to those companies classified as a small, disadvantaged business. After an industry briefing that explained to qualified companies the CPS and type of work required, each of the interested companies then submitted proposals addressing three components: Mission Suitability, Cost, and Past Performance. These proposals were based off the Statement of Work (SOW) written by the SEB. After companies submitted their proposals, the SEB reviewed all three components and then presented their results to the SSO. While the SEB does not select the company receiving the contract, they can make recommendations based on their findings to the SSO, who actually awards the contract. The SEB began work for this contract in July 2003 by writing the SOW and the selection will tentatively occur July 30, 2004. Contract awarding will take place Aug. 15. Following the awarding, the winning company has a 30-day Phase-in Period beginning Sept. 1,2004 and full performance will begin October 1.

Something for Nothing: Cash Flow as a Contract Incentive

DTIC Science & Technology

2016-03-01

Defense AT&L: March-April 2016 16 Something for Nothing “ Cash Flow” as a Contract Incentive John Pritchard n John Krieger Pritchard and...Krieger are professors at the Defense Acquisition University’s Defense Systems Management College at Fort Belvoir, Virginia. During our combined 70...The government actually has complete control over one of the strongest con-tract incentives possible— cash flow. Most important, in our fiscally

Turbulence Characteristics of Swirling Flowfields. Ph.D. Thesis

NASA Technical Reports Server (NTRS)

Jackson, T. W.

1983-01-01

Combustor design phenomena; recirculating flows research; single-wire, six-orientation, eddy dissipation rate, and turbulence modeling measurement; directional sensitivity (DS); calibration equipment, confined jet facility, and hot-wire instrumentation; effects of swirl, strong contraction nozzle, and expansion ratio; and turbulence parameters; uncertain; and DS in laminar jets; turbulent nonswirling jets, and turbulent swirling jets are discussed.

Transformation of dilative and contractive landslide debris into debris flows-An example from marin County, California

USGS Publications Warehouse

Fleming, R.W.; Ellen, S.D.; Algus, M.A.

1989-01-01

The severe rainstorm of January 3, 4 and 5, 1982, in the San Francisco Bay area, California, produced numerous landslides, many of which transformed into damaging debris flows. The process of transformation was studied in detail at one site where only part of a landslide mobilized into several episodes of debris flow. The focus of our investigation was to learn whether the landslide debris dilated or contracted during the transformation from slide to flow. The landslide debris consisted of sandy colluvium that was separable into three soil horizons that occupied the axis of a small topographic swale. Failure involved the entire thickness of colluvium; however, over parts of the landslide, the soil A-horizon failed separately from the remainder of the colluvium. Undisturbed samples were taken for density measurements from outside the landslide, from the failure zone and overlying material from the part of the landslide that did not mobilize into debris flows, and from the debris-flow deposits. The soil A-horizon was contractive and mobilized to flows in a process analogous to liquefaction of loose, granular soils during earthquakes. The soil B- and C-horizons were dilative and underwent 2 to 5% volumetric expansion during landslide movement that permitted mobilization of debris-flow episodes. Several criteria can be used in the field to differentiate between contractive and dilative behavior including lag time between landsliding and mobilization of flow, episodic mobilization of flows, and partial or complete transformation of the landslide. ?? 1989.

Regulation of skeletal muscle blood flow during exercise in ageing humans

PubMed Central

Hearon, Christopher M.

2015-01-01

Abstract The regulation of skeletal muscle blood flow and oxygen delivery to contracting skeletal muscle is complex and involves the mechanical effects of muscle contraction; local metabolic, red blood cell and endothelium‐derived substances; and the sympathetic nervous system (SNS). With advancing age in humans, skeletal muscle blood flow is typically reduced during dynamic exercise and this is due to a lower vascular conductance, which could ultimately contribute to age‐associated reductions in aerobic exercise capacity, a primary predictor of mortality in both healthy and diseased ageing populations. Recent findings have highlighted the contribution of endothelium‐derived substances to blood flow control in contracting muscle of older adults. With advancing age, impaired nitric oxide availability due to scavenging by reactive oxygen species, in conjunction with elevated vasoconstrictor signalling via endothelin‐1, reduces the local vasodilatory response to muscle contraction. Additionally, ageing impairs the ability of contracting skeletal muscle to blunt sympathetic vasoconstriction (i.e. ‘functional sympatholysis’), which is critical for the proper regulation of tissue blood flow distribution and oxygen delivery, and could further reduce skeletal muscle perfusion during high intensity and/or large muscle mass exercise in older adults. We propose that initiation of endothelium‐dependent hyperpolarization is the underlying signalling event necessary to properly modulate sympathetic vasoconstriction in contracting muscle, and that age‐associated impairments in red blood cell adenosine triphosphate release and stimulation of endothelium‐dependent vasodilatation may explain impairments in both local vasodilatation and functional sympatholysis with advancing age in humans. PMID:26332887

Treatment with a Nitric Oxide-Donating NSAID Alleviates Functional Muscle Ischemia in the Mouse Model of Duchenne Muscular Dystrophy

PubMed Central

Thomas, Gail D.; Ye, Jianfeng; De Nardi, Claudio; Monopoli, Angela; Ongini, Ennio; Victor, Ronald G.

2012-01-01

In patients with Duchenne muscular dystrophy (DMD) and the standard mdx mouse model of DMD, dystrophin deficiency causes loss of neuronal nitric oxide synthase (nNOSμ) from the sarcolemma, producing functional ischemia when the muscles are exercised. We asked if functional muscle ischemia would be eliminated and normal blood flow regulation restored by treatment with an exogenous nitric oxide (NO)-donating drug. Beginning at 8 weeks of age, mdx mice were fed a standard diet supplemented with 1% soybean oil alone or in combination with a low (15 mg/kg) or high (45 mg/kg) dose of HCT 1026, a NO-donating nonsteroidal anti-inflammatory agent which has previously been shown to slow disease progression in the mdx model. After 1 month of treatment, vasoconstrictor responses to intra-arterial norepinephrine (NE) were compared in resting and contracting hindlimbs. In untreated mdx mice, the usual effect of muscle contraction to attenuate NE-mediated vasoconstriction was impaired, resulting in functional ischemia: NE evoked similar decreases in femoral blood flow velocity and femoral vascular conductance (FVC) in the contracting compared to resting hindlimbs (ΔFVC contraction/ΔFVC rest = 0.88±0.03). NE-induced functional ischemia was unaffected by low dose HCT 1026 (ΔFVC ratio = 0.92±0.04; P>0.05 vs untreated), but was alleviated by the high dose of the drug (ΔFVC ratio = 0.22±0.03; P<0.05 vs untreated or low dose). The beneficial effect of high dose HCT 1026 was maintained with treatment up to 3 months. The effect of the NO-donating drug HCT 1026 to normalize blood flow regulation in contracting mdx mouse hindlimb muscles suggests a putative novel treatment for DMD. Further translational research is warranted. PMID:23139842

Mass transfer effect of the stalk contraction-relaxation cycle of Vorticella convallaria

NASA Astrophysics Data System (ADS)

Zhou, Jiazhong; Admiraal, David; Ryu, Sangjin

2014-11-01

Vorticella convallaria is a genus of protozoa living in freshwater. Its stalk contracts and coil pulling the cell body towards the substrate at a remarkable speed, and then relaxes to its extended state much more slowly than the contraction. However, the reason for Vorticella's stalk contraction is still unknown. It is presumed that water flow induced by the stalk contraction-relaxation cycle may augment mass transfer near the substrate. We investigated this hypothesis using an experimental model with particle tracking velocimetry and a computational fluid dynamics model. In both approaches, Vorticella was modeled as a solid sphere translating perpendicular to a solid surface in water. After having been validated by the experimental model and verified by grid convergence index test, the computational model simulated water flow during the cycle based on the measured time course of stalk length changes of Vorticella. Based on the simulated flow field, we calculated trajectories of particles near the model Vorticella, and then evaluated the mass transfer effect of Vorticella's stalk contraction based on the particles' motion. We acknowlege support from Laymann Seed Grant of the University of Nebraska-Lincoln.

Determination of Extensional Rheological Properties by Hyperbolic Contraction Flow

NASA Astrophysics Data System (ADS)

Stading, Mats

2008-07-01

Extensional rheologyy is important for diverse applications such as processing of viscoelastic fluids, mouthfeel of semi-solid foods, cell mitosis and baking, and is also a useful tool for testing the applicability of constitutive equations. Despite the documented influence of extensional rheological properties, it is seldom measured due to experimental difficulties. There are only commercial equipments available for low-viscosity fluids by Capillary Breakup and for polymer melts by Meissner-type winding of ribbons around cylinders. Both methods have limited applicability for medium-viscosity fluids such as foods and other biological systems. Contraction flows are extensively studied and a new test method has been developed based on contraction flow through a hyperbolic nozzle. The method is suitable for medium-viscosity fluids and has been validated by comparison to results from Filament Stretching and Capillary Breakup. The hyperbolic contraction flow method has been used to characterize food and medical systems, distinguish between different products having equal shear behavior, quantify ropy mouth feel and to predict foaming behavior of biopolymers.

Contraction of the Ventral Abdomen Potentiates Extracardiac Retrograde Hemolymph Propulsion in the Mosquito Hemocoel

PubMed Central

Andereck, Jonathan W.; King, Jonas G.; Hillyer, Julián F.

2010-01-01

Background Hemolymph circulation in mosquitoes is primarily controlled by the contractile action of a dorsal vessel that runs underneath the dorsal midline and is subdivided into a thoracic aorta and an abdominal heart. Wave-like peristaltic contractions of the heart alternate in propelling hemolymph in anterograde and retrograde directions, where it empties into the hemocoel at the terminal ends of the insect. During our analyses of hemolymph propulsion in Anopheles gambiae, we observed periodic ventral abdominal contractions and hypothesized that they promote extracardiac hemolymph circulation in the abdominal hemocoel. Methodology/Principal Findings We devised methods to simultaneously analyze both heart and abdominal contractions, as well as to measure hemolymph flow in the abdominal hemocoel. Qualitative and quantitative analyses revealed that ventral abdominal contractions occur as series of bursts that propagate in the retrograde direction. Periods of ventral abdominal contraction begin only during periods of anterograde heart contraction and end immediately following a heartbeat directional reversal, suggesting that ventral abdominal contractions function to propel extracardiac hemolymph in the retrograde direction. To test this functional role, fluorescent microspheres were intrathoracically injected and their trajectory tracked throughout the hemocoel. Quantitative measurements of microsphere movement in extracardiac regions of the abdominal cavity showed that during periods of abdominal contractions hemolymph flows in dorsal and retrograde directions at a higher velocity and with greater acceleration than during periods of abdominal rest. Histochemical staining of the abdominal musculature then revealed that ventral abdominal contractions result from the contraction of intrasegmental lateral muscle fibers, intersegmental ventral muscle bands, and the ventral transverse muscles that form the ventral diaphragm. Conclusions/Significance These data show that abdominal contractions potentiate extracardiac retrograde hemolymph propulsion in the abdominal hemocoel during periods of anterograde heart flow. PMID:20886066

AST Critical Propulsion and Noise Reduction Technologies for Future Commercial Subsonic Engines: Separate-Flow Exhaust System Noise Reduction Concept Evaluation

NASA Technical Reports Server (NTRS)

Janardan, B. A.; Hoff, G. E.; Barter, J. W.; Martens, S.; Gliebe, P. R.; Mengle, V.; Dalton, W. N.; Saiyed, Naseem (Technical Monitor)

2000-01-01

This report describes the work performed by General Electric Aircraft Engines (GEAE) and Allison Engine Company (AEC) on NASA Contract NAS3-27720 AoI 14.3. The objective of this contract was to generate quality jet noise acoustic data for separate-flow nozzle models and to design and verify new jet-noise-reduction concepts over a range of simulated engine cycles and flight conditions. Five baseline axisymmetric separate-flow nozzle models having bypass ratios of five and eight with internal and external plugs and 11 different mixing-enhancer model nozzles (including chevrons, vortex-generator doublets, and a tongue mixer) were designed and tested in model scale. Using available core and fan nozzle hardware in various combinations, 28 GEAE/AEC separate-flow nozzle/mixing-enhancer configurations were acoustically evaluated in the NASA Glenn Research Center Aeroacoustic and Propulsion Laboratory. This report describes model nozzle features, facility and data acquisition/reduction procedures, the test matrix, and measured acoustic data analyses. A number of tested core and fan mixing enhancer devices and combinations of devices gave significant jet noise reduction relative to separate-flow baseline nozzles. Inward-flip and alternating-flip core chevrons combined with a straight-chevron fan nozzle exceeded the NASA stretch goal of 3 EPNdB jet noise reduction at typical sideline certification conditions.

Theoretical research of helium pulsating heat pipe under steady state conditions

NASA Astrophysics Data System (ADS)

Xu, D.; Liu, H. M.; Li, L. F.; Huang, R. J.; Wang, W.

2015-12-01

As a new-type heat pipe, pulsating heat pipe (PHP) has several outstanding features, such as great heat transport ability, strong adjustability, small size and simple construction. PHP is a complex two-phase flow system associated with many physical subjects and parameters, which utilizes the pressure and temperature changes in volume expansion and contraction during phase changes to excite the pulsation motion of liquid plugs and vapor bubbles in the capillary tube between the evaporator and the condenser. At present time, some experimental investigation of helium PHP have been done. However, theoretical research of helium PHP is rare. In this paper, the physical and mathematical models of operating mechanism for helium PHP under steady state are established based on the conservation of mass, momentum, and energy. Several important parameters are correlated and solved, including the liquid filling ratio, flow velocity, heat power, temperature, etc. Based on the results, the operational driving force and flow resistances of helium PHP are analysed, and the flow and heat transfer is further studied.

48 CFR 925.7004 - Contract clause.

Code of Federal Regulations, 2010 CFR

2010-10-01

... FOREIGN ACQUISITION Acquisition of Nuclear Hot Cell Services 925.7004 Contract clause. The contracting officer shall insert the clause at 952.225-70, Subcontracting for Nuclear Hot Cell Services, in solicitations and contracts involving nuclear hot cell services. This clause does not flow down to second-tier...

48 CFR 925.7004 - Contract clause.

Code of Federal Regulations, 2012 CFR

2012-10-01

... FOREIGN ACQUISITION Acquisition of Nuclear Hot Cell Services 925.7004 Contract clause. The contracting officer shall insert the clause at 952.225-70, Subcontracting for Nuclear Hot Cell Services, in solicitations and contracts involving nuclear hot cell services. This clause does not flow down to second-tier...

48 CFR 925.7004 - Contract clause.

Code of Federal Regulations, 2014 CFR

2014-10-01

... FOREIGN ACQUISITION Acquisition of Nuclear Hot Cell Services 925.7004 Contract clause. The contracting officer shall insert the clause at 952.225-70, Subcontracting for Nuclear Hot Cell Services, in solicitations and contracts involving nuclear hot cell services. This clause does not flow down to second-tier...

48 CFR 925.7004 - Contract clause.

Code of Federal Regulations, 2013 CFR

2013-10-01

... FOREIGN ACQUISITION Acquisition of Nuclear Hot Cell Services 925.7004 Contract clause. The contracting officer shall insert the clause at 952.225-70, Subcontracting for Nuclear Hot Cell Services, in solicitations and contracts involving nuclear hot cell services. This clause does not flow down to second-tier...

48 CFR 925.7004 - Contract clause.

Code of Federal Regulations, 2011 CFR

2011-10-01

... FOREIGN ACQUISITION Acquisition of Nuclear Hot Cell Services 925.7004 Contract clause. The contracting officer shall insert the clause at 952.225-70, Subcontracting for Nuclear Hot Cell Services, in solicitations and contracts involving nuclear hot cell services. This clause does not flow down to second-tier...

Rarefaction effects in microchannel gas flow driven by rhythmic wall contractions

NASA Astrophysics Data System (ADS)

Chatterjee, Krishnashis; Staples, Anne; Department of Biomedical Engineering; Mechanics, Virginia Tech Collaboration

2015-11-01

Current state of the art microfluidic devices employ precise and timely operation of a complex arrangement of micropumps and valves for fluid transport. A much more novel flow transport mechanism is found in entomological respiratory systems, which involve rhythmic wall contractions for driving the fluid flow. The practical viability of using this technique in future microfluidic devices has been studied earlier. The present study investigates the incorporation of rarefaction effects in the above model of microscale gas flow by including slip boundary conditions. The Navier Stokes equations for gas flow in rectangular microchannel are solved analytically with microscale and lubrication theory assumptions. First order slip boundary conditions are incorporated to account for the rarefaction effects. The dependence of fluid velocities and pressure gradient on the slip boundary conditions is studied. Time averaged unidirectional fluid flow rates are plotted for different phase lags between the contractions, with and without slip in order to obtain an optimum range under different conditions.

Information propagation and nutrient flow in Physarum polycephalum

NASA Astrophysics Data System (ADS)

Amselem, Gabriel; Peaudecerf, Francois; Alim, Karen; Dumais, Jacques; Pringle, Anne; Brenner, Michael

2012-02-01

Basal organisms such as slime mold and fungi grow as extended networks that can reach several square meters in size. Despite lacking a central coordination center, these organisms are able to globally reshape their morphology in response to local cues, such as the presence of a patch of nutrient. How are local signals integrated in these organisms, and how do they lead to an overall response? To answer this question, we focus on the flow of nutrients in the slime mold Physarum polycephalum. This slime mold exhibits internal flow oscillations, as well as periodic contractions of its veins. Using plastic masks, we constrain network growth to simple geometries. This allows for an experimental characterization of the relationship between the contractions and the flow. We next describe the change in the overall oscillation pattern when a food source is presented locally to the slime mold, and its implication on the internal flow. Internal flows are both inferred from the contraction pattern and experimentally measured using fluorescent markers.

Effect of flow and peristaltic mixing on bacterial growth in a gut-like channel

PubMed Central

Cremer, Jonas; Segota, Igor; Yang, Chih-yu; Arnoldini, Markus; Sauls, John T.; Zhang, Zhongge; Gutierrez, Edgar; Groisman, Alex; Hwa, Terence

2016-01-01

The ecology of microbes in the gut has been shown to play important roles in the health of the host. To better understand microbial growth and population dynamics in the proximal colon, the primary region of bacterial growth in the gut, we built and applied a fluidic channel that we call the “minigut.” This is a channel with an array of membrane valves along its length, which allows mimicking active contractions of the colonic wall. Repeated contraction is shown to be crucial in maintaining a steady-state bacterial population in the device despite strong flow along the channel that would otherwise cause bacterial washout. Depending on the flow rate and the frequency of contractions, the bacterial density profile exhibits varying spatial dependencies. For a synthetic cross-feeding community, the species abundance ratio is also strongly affected by mixing and flow along the length of the device. Complex mixing dynamics due to contractions is described well by an effective diffusion term. Bacterial dynamics is captured by a simple reaction–diffusion model without adjustable parameters. Our results suggest that flow and mixing play a major role in shaping the microbiota of the colon. PMID:27681630

Fully developed pipe and triangular channel flow measurement using Magnetic Resonance Velocimetry

NASA Astrophysics Data System (ADS)

Baek, Seungchan; Hwang, Wontae

2017-11-01

Magnetic resonance velocimetry (MRV) is a non-intrusive flow visualization method which is able to measure the 3 dimensional 3 component (3D3C) mean velocity field in complex geometries, using a healthcare MRI scanner. Since this technique is based on nuclear magnetic resonance (NMR), it is free from optical distortion and does not require tracer particles. Due to these powerful advantages, MRV usage is gradually expanding from biomedical fields to the engineering domain. In this study, we validate the performance of MRV by measuring fully developed pipe flow and compare measured data with time averaged DNS data. We then investigate the overall flow characteristics in a triangular channel with a sharp corner. At the sharp corner, boundary layer effects dominate and the effect of turbulence is reduced. This information has implications for engineering applications such as flow in a turbine blade internal cooling passage at the sharp trailing edge. This research was supported by the Seoul National University Research Grant in 2017, and Doosan Heavy Industries & Construction. (Contract No. 2016900298 and 2017900095).

Oscillating flow and heat transfer in a channel with sudden cross section change

NASA Technical Reports Server (NTRS)

Ibrahim, Mounir; Hashim, Waqar

1993-01-01

We have computationally examined oscillating flow (zero mean) between two parallel plates with a sudden change in cross section. The flow was assumed to be laminar incompressible with the inflow velocity uniform over the channel cross section but varying sinusoidally with time. The cases studied cover wide ranges of Re(sub max) (from 187.5 to 2000), Va (from 1 to 10.66), the expansion ratio (1:2 and 1:4) and A(sub r) (2 and 4). Also, three different geometric cases were discussed: (1) asymmetric expansion/contraction; (2) symmetric expansion/contraction; and (3) symmetric blunt body. For these oscillating flow conditions, the fluid undergoes sudden expansion in one-half of the cycle and sudden contraction inthe other half. The instantaneous friction factor, for some ranges of Re(sub max) and Va, deviated substantially from the steady-state friction factor for the same flow parameters. A region has been identified below which the flow is laminar quasi-steady. A videotape showing computer simulations of the oscillating flow demonstrates the usefulness of the current analyses in providing information on the transient hydraulic phenomena.

Purinergic and cholinergic components of bladder contractility and flow.

PubMed

Theobald, R J

1995-01-01

The role of ATP as a neurotransmitter/neuromodulator in the urinary tract has been the subject of much study, particularly whether ATP has a functional role in producing urine flow. Recent studies suggested significant species variation, specifically a variation between cat and other species. This study was performed to determine the in vivo response of cat urinary bladder to pelvic nerve stimulation (PNS) and to the exogenous administration of cholinergic and purinergic agents. In anesthetized cats, bladder contractions and fluid expulsion was measured in response to PNS and to the exogenous administration of cholinergic and purinergic agents. Fluid was instilled into the bladder and any fluid expelled by bladder contractions induced by PNS or exogenous agents was collected in a beaker. The volume was measured in a graduated cylinder and recorded. PNS, carbachol and APPCP produced sustained contractions with significant expulsion of fluid. ATP, ACh and hypogastric nerve stimulation did not produce any significant expulsion of fluid. Atropine, a cholinergic antagonist, inhibited PNS contractions and fluid expulsion with no effect on purinergic actions. There was a significant relationship between the magnitude of the contraction, duration of the contractions and volume of fluid expelled. The data and information from other studies, strongly suggests a functional role for ATP as a cotransmitter in the lower urinary tract different from ACh's role. ATP stimulation of a specific purinergic receptor plays a role in initiation of bladder contractions and perhaps in the initiation of urine flow from the bladder. ACh's role is functionally different and appears to be more involved in maintenance of contractile activity and flow.

Experimental search for Exact Coherent Structures in turbulent small aspect ratio Taylor-Couette flow

NASA Astrophysics Data System (ADS)

Crowley, Christopher J.; Krygier, Michael; Grigoriev, Roman O.; Schatz, Michael F.

2017-11-01

Recent theoretical and experimental work suggests that the dynamics of turbulent flows are guided by unstable nonchaotic solutions to the Navier-Stokes equations. These solutions, known as exact coherent structures (ECS), play a key role in a fundamentally deterministic description of turbulence. In order to quantitatively demonstrate that actual turbulence in 3D flows is guided by ECS, high resolution, 3D-3C experimental measurements of the velocity need to be compared to solutions from direct numerical simulation of the Navier-Stokes equations. In this talk, we will present experimental measurements of fully time resolved, velocity measurements in a volume of turbulence in a counter-rotating, small aspect ratio Taylor-Couette flow. This work is supported by the Army Research Office (Contract # W911NF-16-1-0281).

Hydraulic shock waves in an inclined chute contraction

NASA Astrophysics Data System (ADS)

Jan, C.-D.; Chang, C.-J.

2009-04-01

A chute contraction is a common structure used in hydraulic engineering for typical reasons such as increase of bottom slope, transition from side channel intakes to tunnel spillways, reduction of chute width due to bridges, transition structures in flood diversion works, among others. One of the significant chute contractions in Taiwan is that used in the Yuanshantzu Flood Diversion Project of Keelung River. The diversion project is designed to divert flood water from upper Keelung River into East Sea with a capasity of 1,310 cubic meters per second for mitigating the flood damage of lower part of Keelung River basin in Northern Taiwan. An inclined chute contraction is used to connect Keelung River and a diversion turnel. The inlet and outlet works of the diversion project is located at Ruifang in the Taipei County of north Taiwan. The diameter of diversion tunnel is 12 meters and the total length of tunnel is 2,484 meters. The diversion project has been completed and successfully executed many times since 2004 to lower the water level of Keelung River in typhoon seasons for avioding flooding problems in the lower part of Keelung River basin. Flow in a chute contraction has complicated flow pattern due to the existence of shock waves in it. A simple and useful calculation procedure for the maximum height and its position of shock waves is essentially needed for the preliminary design stage of a chute contraction. Hydraulic shock waves in an inclined chute contraction were experimentally and numerically investigated in this study with the consideration of the effects of sidewall deflection angle, bottom inclination angle and Froude number of approaching flow. The flow pattern of hydraulic shock waves in a chute contraction was observed. The main issue of designing chute contraction is to estimate the height and position of maximum shock wave for the consideration of freeboards. Achieving this aim, the experimental data are adopted and analyzed for the shock angle, the height of maximum shock wave and the corresponding position of maximum shock wave. The dimensionless relations for the shock angle, the height of maximum shock wave and the corresponding position of maximum shock wave are obtained by regression analysis. These empirical regression relations, basically relating to the sidewall deflection angle, bottom angle and approach Froude number, are very useful for further practical engineering applications in chute contraction design for avoiding flow overtopping.

Combustion research for gas turbine engines

NASA Technical Reports Server (NTRS)

Mularz, E. J.; Claus, R. W.

1985-01-01

Research on combustion is being conducted at Lewis Research Center to provide improved analytical models of the complex flow and chemical reaction processes which occur in the combustor of gas turbine engines and other aeropropulsion systems. The objective of the research is to obtain a better understanding of the various physical processes that occur in the gas turbine combustor in order to develop models and numerical codes which can accurately describe these processes. Activities include in-house research projects, university grants, and industry contracts and are classified under the subject areas of advanced numerics, fuel sprays, fluid mixing, and radiation-chemistry. Results are high-lighted from several projects.

Flow Characteristics and Status of CFD Hydrodynamic Model Development in Sudden Contraction Manifold/Orifice Configurations

DTIC Science & Technology

2011-07-01

Branching Configuration 33 6.6 CONTRACTION COEFFICIENT 35 7.0 SUPERCAVITATION 36 7.1 FLOW REATTACHMENT 36 7.1.1 In-Line... SUPERCAVITATION 37 7.2.1 In-Line Configuration Critical Cavitation 37 7.2.2 Dead Head Configuration Critical Cavitation 38 7.2.3 Approach...regimes are: (1) Non-Cavitation, (2) Inception of Cavitation, (3) Full Cavitation, (4) Supercavitation , and (5) Hydraulic Flip. The flow

Rheosensing by impulsive cells at intermediate Reynolds numbers

NASA Astrophysics Data System (ADS)

Mathijssen, Arnold; Bhamla, Saad; Prakash, Manu

2017-11-01

For aquatic organisms, mechanical signals are often carried by the surrounding liquid, through viscous and inertial forces. Here we consider a unicellular yet millimetric ciliate, Spirostomum ambiguum, as a model organism to study hydrodynamic sensing. This protist typically swims at moderate Reynolds numbers, Re < 0.5, but upon stimulation it surges to Re > 100 during impulsive contractions where its elongated body recoils within milliseconds. First, using high-speed PIV and an electrophysiology setup, we deliver controlled voltage pulses to induce these rapid contractions and visualise the vortex flows generated thereby. By comparing these measurements with CFD simulations the range of these hydrodynamic ``signals'' is characterized. Second, we probe the mechano-sensing of the organism with externally applied flows and find a critical shear rate necessary to trigger a contraction. The combination of high Re flow generation and rheosensing could facilitate intercellular communication over large distances. Please also see our other talk ``Collective hydrodynamic communication through ultra-fast contractions''.

The CSM testbed matrix processors internal logic and dataflow descriptions

NASA Technical Reports Server (NTRS)

Regelbrugge, Marc E.; Wright, Mary A.

1988-01-01

This report constitutes the final report for subtask 1 of Task 5 of NASA Contract NAS1-18444, Computational Structural Mechanics (CSM) Research. This report contains a detailed description of the coded workings of selected CSM Testbed matrix processors (i.e., TOPO, K, INV, SSOL) and of the arithmetic utility processor AUS. These processors and the current sparse matrix data structures are studied and documented. Items examined include: details of the data structures, interdependence of data structures, data-blocking logic in the data structures, processor data flow and architecture, and processor algorithmic logic flow.

Modeling Tools Predict Flow in Fluid Dynamics

NASA Technical Reports Server (NTRS)

2010-01-01

"Because rocket engines operate under extreme temperature and pressure, they present a unique challenge to designers who must test and simulate the technology. To this end, CRAFT Tech Inc., of Pipersville, Pennsylvania, won Small Business Innovation Research (SBIR) contracts from Marshall Space Flight Center to develop software to simulate cryogenic fluid flows and related phenomena. CRAFT Tech enhanced its CRUNCH CFD (computational fluid dynamics) software to simulate phenomena in various liquid propulsion components and systems. Today, both government and industry clients in the aerospace, utilities, and petrochemical industries use the software for analyzing existing systems as well as designing new ones."

Unsteady motion, finite Reynolds numbers, and wall effect on Vorticella convallaria contribute contraction force greater than the stokes drag.

PubMed

Ryu, Sangjin; Matsudaira, Paul

2010-06-02

Contraction of Vorticella convallaria, a sessile ciliated protozoan, is completed within a few milliseconds and results in a retraction of its cell body toward the substratum by coiling its stalk. Previous studies have modeled the cell body as a sphere and assumed a drag force that satisfies Stokes' law. However, the contraction-induced flow of the medium is transient and bounded by the substrate, and the maximum Reynolds number is larger than unity. Thus, calculations of contractile force from the drag force are incomplete. In this study, we analyzed fluid flow during contraction by the particle tracking velocimetry and computational fluid dynamics simulations to estimate the contractile force. Particle paths show that the induced flow is limited by the substrate. Simulation-based force estimates suggest that the combined effect of the flow unsteadiness, the finite Reynolds number, and the substrate comprises 35% of the total force. The work done in the early stage of contraction and the maximum power output are similar regardless of the medium viscosity. These results suggest that, during the initial development of force, V. convallaria uses a common mechanism for performing mechanical work irrespective of viscous loading conditions. Copyright (c) 2010 Biophysical Society. Published by Elsevier Inc. All rights reserved.

Sound Modeling Simplifies Vehicle Noise Management

NASA Technical Reports Server (NTRS)

2015-01-01

Under two SBIR contracts with Langley Research Center, Ann Arbor, Michigan-based Comet Technology Corporation developed Comet EnFlow, a software program capable of predicting both high- and low-frequency noise and vibration behavior in plane fuselages and other structures. The company now markets the software to airplane, automobile, and ship manufacturers, and Langley has found an unexpected use for it in leak detection on the International Space Station.

Effects of soil aggregates on debris-flow mobilization: Results from ring-shear experiments

USGS Publications Warehouse

Iverson, Neal R.; Mann, Janet E.; Iverson, Richard M.

2010-01-01

Rates and styles of landslide motion are sensitive to pore-water pressure changes caused by changes in soil porosity accompanying shear deformation. Soil may either contract or dilate upon shearing, depending upon whether its initial porosity is greater or less, respectively, than a critical-state porosity attained after sufficiently high strain. We observed complications in this behavior, however, during rate-controlled (0.02 m s−1) ring-shear experiments conducted on naturally aggregated dense loamy sand at low confining stresses (10.6 and 40 kPa). The aggregated soil first dilated and then contracted to porosities less than initial values, whereas the same soil with its aggregates destroyed monotonically dilated. We infer that aggregates persisted initially during shear and caused dilation before their eventual breakdown enabled net contraction. An implication of this contraction, demonstrated in experiments in which initial soil porosity was varied, is that the value of porosity distinguishing initially contractive from dilative behavior can be significantly larger than the critical-state porosity, which develops only after disaggregation ceases at high strains. In addition, post-dilative contraction may produce excess pore pressures, thereby reducing frictional strength and facilitating debris-flow mobilization. We infer that results of triaxial tests, which generally produce strains at least a factor of ∼ 4 smaller than those we observed at the inception of post-dilative contraction, do not allow soil contraction to be ruled out as a mechanism for debris-flow mobilization in dense soils containing aggregates.

Dynamic Contraction of the Positive Column of a Self-Sustained Glow Discharge in Molecular Gas Flow

NASA Astrophysics Data System (ADS)

Shneider, Mikhail

2014-10-01

Contraction of the gas discharge, when current contracts from a significant volume of weakly ionized plasma into a thin arc channel, was attracted attention of scientists for more than a century. Studies of the contraction (also called constriction) mechanisms, besides carrying interesting science, are of practical importance, especially when contraction should be prevented. A set of time-dependent two-dimensional equations for the non-equilibrium weakly-ionized nitrogen/ air plasma is formulated. The process is described by a set of time-dependent continuity equations for the electrons, positive and negative ions; gas and vibrational temperature; by taking into account the convective heat and plasma losses by the transverse flux. Transition from the uniform to contracted state was analyzed. It was shown that such transition experiences a hysteresis, and that the critical current of the transition increases when the pressure (gas density) drops. Possible coexistence of the contracted and uniform state of the plasma in the discharge where the current flows along the density gradient of the background gas was discussed. In this talk the problems related to the dynamic contraction of the current channel inside a quasineutral positive column of a self-sustained glow discharge in molecular gas in a rectangular duct with convection cooling will be discussed. Study presented in this talk was stimulated by the fact that there are large number of experiments on the dynamic contraction of a glow discharge in nitrogen and air flows and a many of possible applications. Similar processes play a role in the powerful gas-discharge lasers. In addition, the problem of dynamic contraction in the large volume of non-equilibrium weakly ionized plasma is closely related to the problem of streamer to leader transitions in lightning and blue jets.

Scalable Methods for Eulerian-Lagrangian Simulation Applied to Compressible Multiphase Flows

NASA Astrophysics Data System (ADS)

Zwick, David; Hackl, Jason; Balachandar, S.

2017-11-01

Multiphase flows can be found in countless areas of physics and engineering. Many of these flows can be classified as dispersed two-phase flows, meaning that there are solid particles dispersed in a continuous fluid phase. A common technique for simulating such flow is the Eulerian-Lagrangian method. While useful, this method can suffer from scaling issues on larger problem sizes that are typical of many realistic geometries. Here we present scalable techniques for Eulerian-Lagrangian simulations and apply it to the simulation of a particle bed subjected to expansion waves in a shock tube. The results show that the methods presented here are viable for simulation of larger problems on modern supercomputers. This material is based upon work supported by the National Science Foundation Graduate Research Fellowship under Grant No. DGE-1315138. This work was supported in part by the U.S. Department of Energy under Contract No. DE-NA0002378.

Publications in acoustics and noise control from the NASA Langley Research Center during 1940 - 1974

NASA Technical Reports Server (NTRS)

Smith, G. C. (Compiler); Laneave, J. N. (Compiler)

1975-01-01

This document contains reference lists of published Langley Research Center papers in various areas of acoustics and noise control for the period 1940-1974. The research work was performed either in-house by the center staff or by other personnel supported entirely or in part by grants or contracts. The references are listed chronologically and are grouped under the following general headings: (1) Duct acoustics, (2) Propagation and operations, (3) Rotating blade noise, (4) Jet noise, (5) Sonic boom, (6) Flow-surface interaction noise, (7) Human response, and (8) Structural response.

Lymph flow pattern in pleural diaphragmatic lymphatics during intrinsic and extrinsic isotonic contraction.

PubMed

Moriondo, Andrea; Solari, Eleonora; Marcozzi, Cristiana; Negrini, Daniela

2016-01-01

Peripheral rat diaphragmatic lymphatic vessels, endowed with intrinsic spontaneous contractility, were in vivo filled with fluorescent dextrans and microspheres and subsequently studied ex vivo in excised diaphragmatic samples. Changes in diameter and lymph velocity were detected, in a vessel segment, during spontaneous lymphatic smooth muscle contraction and upon activation, through electrical whole-field stimulation, of diaphragmatic skeletal muscle fibers. During intrinsic contraction lymph flowed both forward and backward, with a net forward propulsion of 14.1 ± 2.9 μm at an average net forward speed of 18.0 ± 3.6 μm/s. Each skeletal muscle contraction sustained a net forward-lymph displacement of 441.9 ± 159.2 μm at an average velocity of 339.9 ± 122.7 μm/s, values significantly higher than those documented during spontaneous contraction. The flow velocity profile was parabolic during both spontaneous and skeletal muscle contraction, and the shear stress calculated at the vessel wall at the highest instantaneous velocity never exceeded 0.25 dyne/cm(2). Therefore, we propose that the synchronous contraction of diaphragmatic skeletal muscle fibers recruited at every inspiratory act dramatically enhances diaphragmatic lymph propulsion, whereas the spontaneous lymphatic contractility might, at least in the diaphragm, be essential in organizing the pattern of flow redistribution within the diaphragmatic lymphatic circuit. Moreover, the very low shear stress values observed in diaphragmatic lymphatics suggest that, in contrast with other contractile lymphatic networks, a likely interplay between intrinsic and extrinsic mechanisms be based on a mechanical and/or electrical connection rather than on nitric oxide release. Copyright © 2016 the American Physiological Society.

Contract Financing for Small Business

DTIC Science & Technology

1981-11-01

problem. Small business contractors devote considerable management attention to operating capital and cash flow. Small business contractors are keenly...CONTRACT FINANCING 0FOR SMALL BUSINESS November 1981 -s Paul R. McClenon Prepared pursuant to Department of Defense Contract No. MDA903-81-C-0166...34 i 12 17046 DistIbufios Unlimted !I CONTRACT FINANCING FOR SMALL BUSINESS EXECUTIVE SUMMHARY To perform effectively on a contract, a firm needs

Numerical investigation of exact coherent structures in turbulent small-aspect-ratio Taylor-Couette flow

NASA Astrophysics Data System (ADS)

Krygier, Michael; Crowley, Christopher J.; Schatz, Michael F.; Grigoriev, Roman O.

2017-11-01

As suggested by recent theoretical and experimental studies, fluid turbulence can be described as a walk between neighborhoods of unstable nonchaotic solutions of the Navier-Stokes equation known as exact coherent structures (ECS). Finding ECS in an experimentally-accessible setting is the first step toward rigorous testing of the dynamical role of ECS in 3D turbulence. We found several ECS (both relative periodic orbits and relative equilibria) in a weakly turbulent regime of small-aspect-ratio Taylor-Couette flow with counter-rotating cylinders. This talk will discuss how the geometry of these solutions guides the evolution of turbulent flow in the simulations. This work is supported by the Army Research Office (Contract # W911NF-15-1-0471).

Expanding and Contracting Coronal Loops as Evidence of Vortex Flows Induced by Solar Eruptions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dudík, J.; Zuccarello, F. P.; Aulanier, G.

Eruptive solar flares were predicted to generate large-scale vortex flows at both sides of the erupting magnetic flux rope. This process is analogous to a well-known hydrodynamic process creating vortex rings. The vortices lead to advection of closed coronal loops located at the peripheries of the flaring active region. Outward flows are expected in the upper part and returning flows in the lower part of the vortex. Here, we examine two eruptive solar flares, the X1.1-class flare SOL2012-03-05T03:20 and the C3.5-class SOL2013-06-19T07:29. In both flares, we find that the coronal loops observed by the Atmospheric Imaging Assembly in its 171more » Å, 193 Å, or 211 Å passbands show coexistence of expanding and contracting motions, in accordance with the model prediction. In the X-class flare, multiple expanding and contracting loops coexist for more than 35 minutes, while in the C-class flare, an expanding loop in 193 Å appears to be close by and cotemporal with an apparently imploding loop arcade seen in 171 Å. Later, the 193 Å loop also switches to contraction. These observations are naturally explained by vortex flows present in a model of eruptive solar flares.« less

Snapshot of Active Flow Control Research at NASA Langley

NASA Technical Reports Server (NTRS)

Washburn, A. E.; Gorton, S. Althoff; Anders, S. G.

2002-01-01

NASA Langley is aggressively investigating the potential advantages of active flow control as opposed to more traditional aerodynamic techniques. Many of these techniques will be blended with advanced materials and structures to further enhance payoff. Therefore a multi-disciplinary approach to technology development is being attempted that includes researchers from the more historical disciplines of fluid mechanics. acoustics, material science, structural mechanics, and control theory. The overall goals of the topics presented are focused on advancing the state of knowledge and understanding of controllable fundamental mechanisms in fluids rather than on specific engineering problems. An organizational view of current research activities at NASA Langley in active flow control as supported by several programs such as the Morphing Project under Breakthrough Vehicle Technologies Program (BVT). the Ultra-Efficient Engine Technology Program (UEET), and the 21st Century Aircraft Technology Program (TCAT) is presented. On-center research as well as NASA Langley funded contracts and grants are discussed at a relatively high level. The products of this research, as part of the fundamental NASA R and D (research and development) program. will be demonstrated as either bench-top experiments, wind-tunnel investigations, or in flight tests. Later they will be transferred to more applied research programs within NASA, DOD (Department of Defense), and U.S. industry.

Effect of flow and active mixing on bacterial growth in a colon-like geometry

NASA Astrophysics Data System (ADS)

Cremer, Jonas; Segota, Igor; Arnoldini, Markus; Groisman, Alex; Hwa, Terence

The large intestine harbors bacteria from hundreds of species, with bacterial densities reaching up to 1012 cells per gram. Many different factors influence bacterial growth dynamics and thus bacterial density and microbiota composition. One dominant force is flow which can in principle lead to a washout of bacteria from the proximal colon. Active mixing by Contractions of the colonic wall together with bacterial growth might counteract such flow-forces and allow high bacterial densities to occur. As a step towards understanding bacterial growth in the presence of mixing and flow, we constructed an in-vitro setup where controlled wall-deformations of a channel emulate Contractions. We investigate growth along the channel under a steady nutrient inflow. In the limits of no or very frequent Contractions, the device behaves like a plug-flow reactor and a chemostat respectively. Depending on mixing and flow, we observe varying spatial gradients in bacterial density along the channel. Active mixing by deformations of the channel wall is shown to be crucial in maintaining a steady-state bacterial population in the presence of flow. The growth-dynamics is quantitatively captured by a simple mathematical model, with the effect of mixing described by an effective diffusion term.

Resistance properties of coal-water slurry flowing through local piping fittings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Meng; Duan, Yu Feng

2009-07-15

Local resistance characteristics of coal-water slurry (CWS) flowing through three types of piping components, namely gradual contractions, sudden contractions and 90 horizontal bends, were investigated at a transportation test facility. The results show that CWS exhibits different rheological behaviors, i.e., the shear-thinning, Newtonian, and shear-thicken, at different shear rates. When CWS flows through the gradual contractions, the local pressure loss firstly decreases to a minimum, and then increases as the gradual contraction angle ({theta}) increases. When the CWS flow through the sudden contractions, with the increase of pipe diameter ratio ({beta}), the local pressure loss increases for the two kindsmore » of CWS, SHEN-HUA (S-H) CWS and YAN-ZHOU (Y-Z) CWS whose mass concentration range from 57% to 59% and 59% to 62%, respectively. For 90 horizontal bends, there is an optimal value of the bend diameter ratio (Rc/D) at which the local pressure loss is the least. Furthermore, the local resistance coefficient (K) in the empirical correlations is determined from the experimental data. The correlations show that as Re increases, K of the three fittings declines quickly at first. However, with further increase in Re, K shows different behaviors for the three fittings due to the special rheological property of CWS at higher shear rates. The factors of {theta}, {beta} and Rc/D have minor effects on K. (author)« less

Resistance properties of coal-water slurry flowing through local piping fittings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meng, L.; Duan, Y.F.

2009-07-15

Local resistance characteristics of coal-water slurry (CWS) flowing through three types of piping components, namely gradual contractions, sudden contractions and 90 horizontal bends, were investigated at a transportation test facility. The results show that CWS exhibits different rheological behaviors, i.e., the shear-thinning, Newtonian, and shear-thicken, at different shear rates. When CWS flows through the gradual contractions, the local pressure loss firstly decreases to a minimum, and then increases as the gradual contraction angle {theta} increases. When the CWS flow through the sudden contractions, with the increase of pipe diameter ratio {beta}, the local pressure loss increases for the two kindsmore » of CWS, SHEN-HUA (S-H) CWS and YAN-ZHOU (Y-Z) CWS whose mass concentration range from 57% to 59% and 59% to 62%, respectively. For 90 horizontal bends, there is an optimal value of the bend diameter ratio (Rc/D) at which the local pressure loss is the least. Furthermore, the local resistance coefficient (K) in the empirical correlations is determined from the experimental data. The correlations show that as Re increases, K of the three fittings declines quickly at first. However, with further increase in Re, K shows different behaviors for the three fittings due to the special rheological property of CWS at higher shear rates. The factors of theta, beta and Rc/D have minor effects on K.« less

Abrupt contraction flow of magnetorheological fluids

NASA Astrophysics Data System (ADS)

Kuzhir, P.; López-López, M. T.; Bossis, G.

2009-05-01

Contraction and expansion flows of magnetorheological fluids occur in a variety of smart devices. It is important therefore to learn how these flows can be controlled by means of applied magnetic fields. This paper presents a first investigation into the axisymmetric flow of a magnetorheological fluid through an orifice (so-called abrupt contraction flow). The effect of an external magnetic field, longitudinal or transverse to the flow, is examined. In experiments, the pressure-flow rate curves were measured, and the excess pressure drop (associated with entrance and exit losses) was derived from experimental data through the Bagley correction procedure. The effect of the longitudinal magnetic field is manifested through a significant increase in the slope of the pressure-flow rate curves, while no discernible yield stress occurs. This behavior, observed at shear Mason numbers 10

77 FR 26595 - Self-Regulatory Organizations; NASDAQ OMX PHLX LLC; Suspension of and Order Instituting...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-04

...'') resulting from a Customer order that is (1) directed to it by an order flow provider, and (2) executed by it... rebates, which attracts additional Customer order flow to the Exchange and benefits all market... Customer Rebate for Adding Liquidity from $0.30 per contract to $0.32 per contract; (2) created a new...

48 CFR 1235.7000 - Contract clause.

Code of Federal Regulations, 2012 CFR

2012-10-01

... OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING Research Misconduct 1235.7000 Contract clause. The contracting officer shall insert the clause at (TAR) 48 CFR 1252.235-70, Research Misconduct, in... Policy on Research Misconduct,” dated February 2002. ...

48 CFR 1235.7000 - Contract clause.

Code of Federal Regulations, 2013 CFR

2013-10-01

... OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING Research Misconduct 1235.7000 Contract clause. The contracting officer shall insert the clause at (TAR) 48 CFR 1252.235-70, Research Misconduct, in... Policy on Research Misconduct,” dated February 2002. ...

48 CFR 1235.7000 - Contract clause.

Code of Federal Regulations, 2011 CFR

2011-10-01

... OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING Research Misconduct 1235.7000 Contract clause. The contracting officer shall insert the clause at (TAR) 48 CFR 1252.235-70, Research Misconduct, in... Policy on Research Misconduct,” dated February 2002. ...

48 CFR 1235.7000 - Contract clause.

Code of Federal Regulations, 2010 CFR

2010-10-01

... OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING Research Misconduct 1235.7000 Contract clause. The contracting officer shall insert the clause at (TAR) 48 CFR 1252.235-70, Research Misconduct, in... Policy on Research Misconduct,” dated February 2002. ...

48 CFR 46.308 - Cost-reimbursement research and development contracts.

Code of Federal Regulations, 2011 CFR

2011-10-01

... research and development contracts. 46.308 Section 46.308 Federal Acquisition Regulations System FEDERAL... research and development contracts. The contracting officer shall insert the clause at 52.246-8, Inspection of Research and Development—Cost-Reimbursement, in solicitations and contracts for research and...

48 CFR 46.308 - Cost-reimbursement research and development contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... research and development contracts. 46.308 Section 46.308 Federal Acquisition Regulations System FEDERAL... research and development contracts. The contracting officer shall insert the clause at 52.246-8, Inspection of Research and Development—Cost-Reimbursement, in solicitations and contracts for research and...

Dynamic contraction of the positive column of a self-sustained glow discharge in air flow

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shneider, M. N.; Mokrov, M. S.; Milikh, G. M.

We study the dynamic contraction of a self-sustained glow discharge in air in a rectangular duct with convective cooling. A two dimensional numerical model of the plasma contraction was developed in a cylindrical frame. The process is described by a set of time-dependent continuity equations for the electrons, positive and negative ions; gas and vibrational temperature; and equations which account for the convective heat and plasma losses by the transverse flux. Transition from the uniform to contracted state was analyzed. It was shown that such transition experiences a hysteresis, and that the critical current of the transition increases when themore » gas density drops. Possible coexistence of the contracted and uniform state of the plasma in the discharge, where the current flows along the density gradient of the background gas, is discussed.« less

3D power Doppler ultrasound assessment of placental perfusion during uterine contraction in labor.

PubMed

Sato, Miki; Noguchi, Junko; Mashima, Masato; Tanaka, Hirokazu; Hata, Toshiyuki

2016-09-01

To assess placental perfusion during spontaneous or induced uterine contraction in labor at term using placental vascular sonobiopsy (PVS) by 3D power Doppler ultrasound with the VOCAL imaging analysis program. PVS was performed in 50 normal pregnancies (32 in spontaneous labor group [SLG], and 18 in induced labor group with oxytocin or prostaglandin F2α [ILG]) at 37-41 weeks of gestation to assess placental perfusion during uterine contraction in labor. Only pregnancies with an entirely visualized anterior placenta were included in the study. Data acquisition was performed before, during (at the peak of contraction), and after uterine contraction. 3D power Doppler indices such as the vascularization index (VI), flow index (FI), and vascularization flow index (VFI) were calculated in each placenta. There were no abnormal fetal heart rate tracings during contraction in either group. VI and VFI values were significantly reduced during uterine contraction in both groups (SLG, -33.4% [-97.0-15.2%], and ILG, -49.6% [-78.2--4.0%]), respectively (P < 0.001). The FI value in the ILG group was significantly lower during uterine contraction (P = 0.035), whereas it did not change during uterine contraction in the SLG group. After uterine contraction, all vascular indices returned almost to the same level as that before uterine contraction. However, the FI value in ILG (-8.6%, [-19.7-16.0%]) was significantly lower than that in SLG (2.4%, [-13.4-38.1%]) after uterine contraction (P < 0.05). All 3D power Doppler indices (VI, FI, and VFI) during uterine contraction (at the peak of contraction) showed a correlation greater than 0.7, with good intra- and inter-observer agreements. Our findings suggest that uterine contraction in both spontaneous and induced labors causes a significant reduction in placental perfusion. Reduced placental blood flow in induced uterine contraction has a tendency to be marked compared with that in spontaneous uterine contraction. To the best of our knowledge, this is the first study on the non-invasive assessment of placental perfusion during uterine contraction in labor using 3D power Doppler ultrasound. However, the data and their interpretation in the present study should be taken with some degree of caution because of the small number of subjects studied. Further studies involving a larger sample size are needed to assess placental perfusion and vascularity using PVS during normal and abnormal uterine contractions in normal and high-risk pregnancies. Copyright © 2016 Elsevier Ltd. All rights reserved.

Investigation of flowfields found in typical combustor geometries

NASA Technical Reports Server (NTRS)

Lilley, D. G.

1985-01-01

Activities undertaken during the entire course of research are summarized. Studies were concerned with experimental and theoretical research on 2-D axisymmetric geometries under low speed nonreacting, turbulent, swirling flow conditions typical of gas turbine and ramjet combustion chambers. They included recirculation zone characterization, time-mean and turbulence simulation in swirling recirculating flow, sudden and gradual expansion flowfields, and furher complexities and parameter influences. The study included the investigation of: a complete range of swirl strengths; swirler performance; downstream contraction nozzle sizes and locations; expansion ratios; and inlet side-wall angles. Their individual and combined effects on the test section flowfield were observed, measured and characterized. Experimental methods included flow visualization (with smoke and neutrally-buoyant helium-filled soap bubbles), five-hole pitot probe time-mean velocity field measurements, and single-, double-, and triple-wire hot-wire anemometry measurements of time-mean velocities, normal and shear Reynolds sresses. Computational methods included development of the STARPIC code from the primitive-variable TEACH computer code, and its use in flowfield prediction and turbulence model development.

Flow Induced Vibration Program at Argonne National Laboratory

NASA Astrophysics Data System (ADS)

1984-01-01

The Argonne National Laboratory's Flow Induced Vibration Program, currently residing in the Laboratory's Components Technology Division is discussed. Throughout its existence, the overall objective of the program was to develop and apply new and/or improved methods of analysis and testing for the design evaluation of nuclear reactor plant components and heat exchange equipment from the standpoint of flow induced vibration. Historically, the majority of the program activities were funded by the US Atomic Energy Commission, the Energy Research and Development Administration, and the Department of Energy. Current DOE funding is from the Breeder Mechanical Component Development Division, Office of Breeder Technology Projects; Energy Conversion and Utilization Technology Program, Office of Energy Systems Research; and Division of Engineering, Mathematical and Geosciences, office of Basic Energy Sciences. Testing of Clinch River Breeder Reactor upper plenum components was funded by the Clinch River Breeder Reactor Plant Project Office. Work was also performed under contract with Foster Wheeler, General Electric, Duke Power Company, US Nuclear Regulatory Commission, and Westinghouse.

Visualizing Coolant Flow in Sodium Reactor Subassemblies

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2010-01-01

Uniformity of temperature controls peak power output. Interchannel cross-flow is the principal cross-assembly energy transport mechanism. The areas of fastest flow all occur at the exterior of the assembly. Further, the fast moving region winds around the assembly in a continuous swath. This Nek5000 simulation uses an unstructured mesh with over one billion grid points, resulting in five billion degrees of freedom per time slice. High speed patches of turbulence due to vertex shedding downstream of the wires persist for about a quarter of the wire-wrap periodic length. Credits: Science: Paul Fisher and Aleks Obabko, Argonne National Laboratory. Visualization: Hankmore » Childs and Janet Jacobsen, Lawrence Berkeley National Laboratory. This research used resources of the Argonne Leadership Computing Facility at Argonne National Laboratory, which is supported by the Office of Science of the U.S. Dept. of Energy under contract DE-AC02-06CH11357. This research was sponsored by the Department of Energy's Office of Nuclear Energy's NEAMS program.« less

PHYSICAL MODELING OF CONTRACTED FLOW.

USGS Publications Warehouse

Lee, Jonathan K.

1987-01-01

Experiments on steady flow over uniform grass roughness through centered single-opening contractions were conducted in the Flood Plain Simulation Facility at the U. S. Geological Survey's Gulf Coast Hydroscience Center near Bay St. Louis, Miss. The experimental series was designed to provide data for calibrating and verifying two-dimensional, vertically averaged surface-water flow models used to simulate flow through openings in highway embankments across inundated flood plains. Water-surface elevations, point velocities, and vertical velocity profiles were obtained at selected locations for design discharges ranging from 50 to 210 cfs. Examples of observed water-surface elevations and velocity magnitudes at basin cross-sections are presented.

A numerical simulation of peristaltic motion in the ureter using fluid structure interactions.

PubMed

Vahidi, Bahman; Fatouraee, Nasser

2007-01-01

An axisymmetric model with fluid-structure interactions (FSI) is introduced and solved to perform ureter flow and stress analysis. The Navier-Stokes equations are solved for the fluid and a linear elastic model for ureter is used. The finite element equations for both the structure and the fluid were solved by the Newton-Raphson iterative method. Our results indicated that shear stresses were high around the throat of moving contracted wall. The pressure gradient magnitude along the ureter wall and the symmetry line had the maximum value around the throat of moving contracted wall which decreased as the peristalsis propagates toward the bladder. The flow rate at the ureter outlet at the end of the peristaltic motion was about 650 mm3/s. During propagation of the peristalsis toward the bladder, the inlet backward flow region was limited to the areas near symmetry line but the inner ureter backward flow regions extended to the whole ureter contraction part. The backward flow was vanished after 1.5 seconds of peristalsis propagation start up and after that time the urine flow was forward in the whole ureter length, so reflux is more probable to be present at the beginning of the wall peristaltic motion.

Incidence angle bounds for lip flow separation of three 13.97-centimeter-diameter inlets

NASA Technical Reports Server (NTRS)

Luidens, R. W.; Abbott, J. M.

1976-01-01

Low speed wind tunnel tests were conducted to establish a procedure for determining inlet-lip flow separation and to make preliminary examination of the incidence angle bounds for lip flow separation on inlets intended for the nacelles of STOL (short takeoff and landing) aircraft. Three inlets were tested. Two of the inlets had short centerbodies with lower lip area contraction ratios of 1.30 and 1.44. The third inlet had a cylindrical centerbody extended forward into the inlet throat with a lower lip area contraction ratio of 1.44. The inlets were sized to fit a 13.97 centimeter-diameter fan. For inlet throat Mach numbers less than about 0.43, the lip flow separation angle was increased by either increasing the ratio of throat velocity to freestream velocity (Vt/Vo) or by increasing the lower lip area contraction ratio. For throat Mach numbers greater than a certain value (ranging from 0.43 to 0.52), increasing throat Mach number in some cases resulted in a decrease in the lip flow separation angle. Extending a cylindrical centerbody into the inlet throat increased the flow separation angle for nearly all values of Vt/Vo.

Study on the Effect of Thermal and Magnetic Stimulation by Measuring of the Peripheral Blood Flow and Skin Temperature

NASA Astrophysics Data System (ADS)

Kubota, Kouhei; Nuruki, Atsuo; Tamari, Youzou; Yunokuchi, Kazutomo

Recently, the stiff shoulder accompanying the muscle fatigue becomes an issue of public concern. Therefore, we paid attention to the effect of the thermal and magnetic stimulation for the muscle fatigue. The maximum voluntary contraction has recovered significantly, and also peripheral blood flow has increased by stimulation. In order to evaluate if the thermal and magnetic stimulation has any effects, three parameters was measured, which are the maximum voluntary contraction, peripheral blood flow and skin temperature. The skin temperature, however, did not changed significantly.

Hydrodynamic Contributions to Amoeboid Cell Motility

NASA Astrophysics Data System (ADS)

Lewis, Owen; Guy, Robert

2012-11-01

Understanding the methods by which cells move is a fundamental problem in modern biology. Recent evidence has shown that the fluid dynamics of cytoplasm can play a vital role in cellular motility. The slime mold Physarum polycephalum provides an excellent model organism for the study of amoeboid motion. In this research, we use a simply analytic model in conjuction with computational experiments to investigate intracellular fluid flow in a simple model of Physarum. Of particlar interest are stresses generated by cytoplasmic flow which may be used to aid in cellular motility. In our numerical model, the Immersed Boundary Method is used to account for such stresses. We investigate the relationship between contraction waves, flow waves, adhesion, and locomotive forces in an attempt to characterize conditions necessary to generate directed motion.

48 CFR 832.202-4 - Security for Government financing.

Code of Federal Regulations, 2013 CFR

2013-10-01

... appropriate officer of the firm. (b) A cash flow forecast for the remainder of the contract term showing the planned origin and use of cash within the firm or branch performing the contract. (c) Information on financing arrangements disclosing the availability of cash to finance contract performance, the contractor's...

48 CFR 832.202-4 - Security for Government financing.

Code of Federal Regulations, 2011 CFR

2011-10-01

... appropriate officer of the firm. (b) A cash flow forecast for the remainder of the contract term showing the planned origin and use of cash within the firm or branch performing the contract. (c) Information on financing arrangements disclosing the availability of cash to finance contract performance, the contractor's...

"Financial Emergency" and the Faculty Furlough: A Breach of Contract.

ERIC Educational Resources Information Center

Richards, Mary Sanders

1984-01-01

The power of the university to breach faculty contracts in order to meet its temporary cash-flow problems and the rights of faculty when this breach occurs are discussed. To avoid litigation, a university must have established internal guidelines which can be incorporated into an employment contract. (MLW)

48 CFR 235.070-1 - Indemnification under research and development contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... research and development contracts. 235.070-1 Section 235.070-1 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 235.070-1 Indemnification under research and development contracts. (a...

High Resolution DNS of Turbulent Flows using an Adaptive, Finite Volume Method

NASA Astrophysics Data System (ADS)

Trebotich, David

2014-11-01

We present a new computational capability for high resolution simulation of incompressible viscous flows. Our approach is based on cut cell methods where an irregular geometry such as a bluff body is intersected with a rectangular Cartesian grid resulting in cut cells near the boundary. In the cut cells we use a conservative discretization based on a discrete form of the divergence theorem to approximate fluxes for elliptic and hyperbolic terms in the Navier-Stokes equations. Away from the boundary the method reduces to a finite difference method. The algorithm is implemented in the Chombo software framework which supports adaptive mesh refinement and massively parallel computations. The code is scalable to 200,000 + processor cores on DOE supercomputers, resulting in DNS studies at unprecedented scale and resolution. For flow past a cylinder in transition (Re = 300) we observe a number of secondary structures in the far wake in 2D where the wake is over 120 cylinder diameters in length. These are compared with the more regularized wake structures in 3D at the same scale. For flow past a sphere (Re = 600) we resolve an arrowhead structure in the velocity in the near wake. The effectiveness of AMR is further highlighted in a simulation of turbulent flow (Re = 6000) in the contraction of an oil well blowout preventer. This material is based upon work supported by the U.S. Department of Energy, Office of Science, Office of Advanced Scientific Computing Research, Applied Mathematics program under Contract Number DE-AC02-05-CH11231.

48 CFR 335.071 - Special determinations and findings affecting research and development contracting.

Code of Federal Regulations, 2010 CFR

2010-10-01

... findings affecting research and development contracting. 335.071 Section 335.071 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 335.071 Special determinations and findings affecting research and development contracting. OPDIV...

A simple hydrodynamic model of a laminar free-surface jet in horizontal or vertical flight

NASA Astrophysics Data System (ADS)

Haustein, Herman D.; Harnik, Ron S.; Rohlfs, Wilko

2017-08-01

A useable model for laminar free-surface jet evolution during flight, for both horizontal and vertical jets, is developed through joint analytical, experimental, and simulation methods. The jet's impingement centerline velocity, recently shown to dictate stagnation zone heat transfer, encompasses the entire flow history: from pipe-flow velocity profile development to profile relaxation and jet contraction during flight. While pipe-flow is well-known, an alternative analytic solution is presented for the centerline velocity's viscous-driven decay. Jet-contraction is subject to influences of surface tension (We), pipe-flow profile development, in-flight viscous dissipation (Re), and gravity (Nj = Re/Fr). The effects of surface tension and emergence momentum flux (jet thrust) are incorporated analytically through a global momentum balance. Though emergence momentum is related to pipe flow development, and empirically linked to nominal pipe flow-length, it can be modified to incorporate low-Re downstream dissipation as well. Jet contraction's gravity dependence is extended beyond existing uniform-velocity theory to cases of partially and fully developed profiles. The final jet-evolution model relies on three empirical parameters and compares well to present and previous experiments and simulations. Hence, micro-jet flight experiments were conducted to fill-in gaps in the literature: jet contraction under mild gravity-effects, and intermediate Reynolds and Weber numbers (Nj = 5-8, Re = 350-520, We = 2.8-6.2). Furthermore, two-phase direct numerical simulations provided insight beyond the experimental range: Re = 200-1800, short pipes (Z = L/d . Re ≥ 0.01), variable nozzle wettability, and cases of no surface tension and/or gravity.

Contract portfolio optimization for a gasoline supply chain

NASA Astrophysics Data System (ADS)

Wang, Shanshan

Major oil companies sell gasoline through three channels of trade: branded (associated with long-term contracts), unbranded (associated with short-term contracts), and spot market. The branded channel provides them with a long-term secured and sustainable demand source, but requires an inflexible long-term commitment with demand and price risks. The unbranded channel provides a medium level of allocation flexibility. The spot market provides them with the greatest allocation flexibility to the changing market conditions, but the spot market's illiquidity mitigates this benefit. In order to sell the product in a profitable and sustainable way, they need an optimal contract portfolio. This dissertation addresses the contract portfolio optimization problem from different perspectives (retrospective view and forward-looking view) at different levels (strategic level, tactical level and operational level). The objective of the retrospective operational model is to develop a financial case to estimate the business value of having a dynamic optimization model and quantify the opportunity values missed in the past. This model proves the financial significance of the problem and provides top management valuable insights into the business. BP has applied the insights and principles gained from this work and implemented the model to the entire Midwest gasoline supply chain to retrospectively review optimization opportunities. The strategic model is the most parsimonious model that captures the essential economic tradeoffs among different contract types, to demonstrate the need for a contract portfolio and what drives the portfolio. We examine the properties of the optimal contract portfolio and provide a comparative statics analysis by changing the model parameters. As the strategic model encapsulates the business problem at the macroscopic level, the tactical model resolves lower level issues. It considers the time dynamics, the information flow and contracting flow. Using this model, we characterize a simple and easily implementable dynamic contract portfolio policy that would enable the company to dynamically rebalance its supply contract portfolio over time in anticipation of the future market conditions in each individual channel while satisfying the contractual obligations. The optimal policy is a state-dependent base-share contract portfolio policy characterized by a branded base-share level and an unbranded contract commitment combination, given as a function of the initial information state. Using real-world market data, we estimate the model parameters. We also apply an efficient modified policy iteration method to compute the optimal contract portfolio strategies and corresponding profit value. We present computational results in order to obtain insights into the structure of optimal policies, capture the value of the dynamic contract portfolio policy by comparing it with static policies, and illustrate the sensitivity of the optimal contract portfolio and corresponding profit value in terms of the different parameters. Considering the geographic dispersion of different market areas and the pipeline network together with the dynamic contract portfolio optimization problem, we formulate a forward-looking operational model, which could be used by gasoline suppliers for lower-level planning. Finally, we discuss the generalization of the framework to other problems and applications, as well as further research.

Renal vascular responses to static handgrip: role of muscle mechanoreflex

NASA Technical Reports Server (NTRS)

Momen, Afsana; Leuenberger, Urs A.; Ray, Chester A.; Cha, Susan; Handly, Brian; Sinoway, Lawrence I.

2003-01-01

During exercise, the sympathetic nervous system is activated, which causes vasoconstriction. The autonomic mechanisms responsible for this vasoconstriction vary based on the particular tissue being studied. Attempts to examine reflex control of the human renal circulation have been difficult because of technical limitations. In this report, the Doppler technique was used to examine renal flow velocity during four muscle contraction paradigms in conscious humans. Flow velocity was divided by mean arterial blood pressure to yield an index of renal vascular resistance (RVR). Fatiguing static handgrip (40% of maximal voluntary contraction) increased RVR by 76%. During posthandgrip circulatory arrest, RVR remained above baseline (2.1 +/- 0.2 vs. 2.8 +/- 0.2 arbitrary units; P < 0.017) but was only 40% of the end-grip RVR value. Voluntary biceps contraction increased RVR within 10 s of initiation of contraction. This effect was not associated with an increase in blood pressure. Finally, involuntary biceps contraction also raised RVR. We conclude that muscle contraction evokes renal vasoconstriction in conscious humans. The characteristic of this response is consistent with a primary role for mechanically sensitive afferents. This statement is based on the small posthandgrip circulatory arrest response and the vasoconstriction that was observed with involuntary biceps contraction.

Time-evolving bubbles in two-dimensional stokes flow

NASA Technical Reports Server (NTRS)

Tanveer, Saleh; Vasconcelos, Giovani L.

1994-01-01

A general class of exact solutions is presented for a time evolving bubble in a two-dimensional slow viscous flow in the presence of surface tension. These solutions can describe a bubble in a linear shear flow as well as an expanding or contracting bubble in an otherwise quiescent flow. In the case of expanding bubbles, the solutions have a simple behavior in the sense that for essentially arbitrary initial shapes the bubble will asymptote an expanding circle. Contracting bubbles, on the other hand, can develop narrow structures ('near-cusps') on the interface and may undergo 'break up' before all the bubble-fluid is completely removed. The mathematical structure underlying the existence of these exact solutions is also investigated.

48 CFR 1235.7000 - Contract clause.

Code of Federal Regulations, 2014 CFR

2014-10-01

... all solicitations and contracts for research and development. For further information, see DOT's Implementation Guidance for Executive Office of the President, Office of Science and Technology Policy, “Federal... OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING Research Misconduct 1235.7000 Contract clause...

Muscle contraction increases carnitine uptake via translocation of OCTN2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Furuichi, Yasuro; Sugiura, Tomoko; Kato, Yukio

Highlights: Black-Right-Pointing-Pointer Muscle contraction augmented carnitine uptake into rat hindlimb muscles. Black-Right-Pointing-Pointer An increase in carnitine uptake was due to an intrinsic clearance, not blood flow. Black-Right-Pointing-Pointer Histochemical analysis showed sarcolemmal OCTN2 was emphasized after contraction. Black-Right-Pointing-Pointer OCTN2 protein in sarcolemmal fraction was increased in contracting muscles. -- Abstract: Since carnitine plays an important role in fat oxidation, influx of carnitine could be crucial for muscle metabolism. OCTN2 (SLC22A5), a sodium-dependent solute carrier, is assumed to transport carnitine into skeletal muscle cells. Acute regulation of OCTN2 activity in rat hindlimb muscles was investigated in response to electrically induced contractile activity.more » The tissue uptake clearance (CL{sub uptake}) of L-[{sup 3}H]carnitine during muscle contraction was examined in vivo using integration plot analysis. The CL{sub uptake} of [{sup 14}C]iodoantipyrine (IAP) was also determined as an index of tissue blood flow. To test the hypothesis that increased carnitine uptake involves the translocation of OCTN2, contraction-induced alteration in the subcellular localization of OCTN2 was examined. The CL{sub uptake} of L-[{sup 3}H]carnitine in the contracting muscles increased 1.4-1.7-fold as compared to that in the contralateral resting muscles (p < 0.05). The CL{sub uptake} of [{sup 14}C]IAP was much higher than that of L-[{sup 3}H]carnitine, but no association between the increase in carnitine uptake and blood flow was obtained. Co-immunostaining of OCTN2 and dystrophin (a muscle plasma membrane marker) showed an increase in OCTN2 signal in the plasma membrane after muscle contraction. Western blotting showed that the level of sarcolemmal OCTN2 was greater in contracting muscles than in resting muscles (p < 0.05). The present study showed that muscle contraction facilitated carnitine uptake in skeletal muscles, possibly via the contraction-induced translocation of its specific transporter OCTN2 to the plasma membrane.« less

48 CFR 35.015 - Contracts for research with educational institutions and nonprofit organizations.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Contracts for research with educational institutions and nonprofit organizations. 35.015 Section 35.015 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.015 Contracts for research...

48 CFR 35.015 - Contracts for research with educational institutions and nonprofit organizations.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Contracts for research with educational institutions and nonprofit organizations. 35.015 Section 35.015 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.015 Contracts for research...

48 CFR 35.015 - Contracts for research with educational institutions and nonprofit organizations.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Contracts for research with educational institutions and nonprofit organizations. 35.015 Section 35.015 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.015 Contracts for research...

Stochastic Stabilityfor Contracting Lorenz Maps and Flows

NASA Astrophysics Data System (ADS)

Metzger, R. J.

In a previous work [M], we proved the existence of absolutely continuous invariant measures for contracting Lorenz-like maps, and constructed Sinai-Ruelle-Bowen measures f or the flows that generate them. Here, we prove stochastic stability for such one-dimensional maps and use this result to prove that the corresponding flows generating these maps are stochastically stable under small diffusion-type perturbations, even though, as shown by Rovella [Ro], they are persistent only in a measure theoretical sense in a parameter space. For the one-dimensional maps we also prove strong stochastic stability in the sense of Baladi and Viana[BV].

Small Business Innovations

NASA Technical Reports Server (NTRS)

1994-01-01

A Small Business Innovation Research (SBIR) contract resulted in a series of commercially available lasers, which have application in fiber optic communications, difference frequency generation, fiber optic sensing and general laboratory use. Developed under a Small Business Innovation Research (SBIR) contract, the Phase Doppler Particles Analyzer is a non-disruptive, highly accurate laser-based method of determining particle size, number density, trajectory, turbulence and other information about particles passing through a measurement probe volume. The system consists of an optical transmitter and receiver, signal processor and computer with data acquisition and analysis software. A variety of systems are offered for applications including spray characterization for paint, and agricultural and other sprays. The Microsizer, a related product, is used in medical equipment manufacturing and analysis of contained flows. High frequency components and subsystems produced by Millitech Corporation are marketed for both research and commercial use. These systems, which operate in the upper portion of the millimeter wave, resulted from a number of Small Business Innovation Research (SBIR) projects. By developing very high performance mixers and multipliers, the company has advanced the state of the art in sensitive receiver technology. Components are used in receivers and transceivers for monitoring chlorine monoxides, ozone, in plasma characterization and in material properties characterization.

Experimental study of the influence of flow passage subtle variation on mixed-flow pump performance

NASA Astrophysics Data System (ADS)

Bing, Hao; Cao, Shuliang

2014-05-01

In the mixed-flow pump design, the shape of the flow passage can directly affect the flow capacity and the internal flow, thus influencing hydraulic performance, cavitation performance and operation stability of the mixed-flow pump. However, there is currently a lack of experimental research on the influence mechanism. Therefore, in order to analyze the effects of subtle variations of the flow passage on the mixed-flow pump performance, the frustum cone surface of the end part of inlet contraction flow passage of the mixed-flow pump is processed into a cylindrical surface and a test rig is built to carry out the hydraulic performance experiment. In this experiment, parameters, such as the head, the efficiency, and the shaft power, are measured, and the pressure fluctuation and the noise signal are also collected. The research results suggest that after processing the inlet flow passage, the head of the mixed-flow pump significantly goes down; the best efficiency of the mixed-flow pump drops by approximately 1.5%, the efficiency decreases more significantly under the large flow rate; the shaft power slightly increases under the large flow rate, slightly decreases under the small flow rate. In addition, the pressure fluctuation amplitudes on both the impeller inlet and the diffuser outlet increase significantly with more drastic pressure fluctuations and significantly lower stability of the internal flow of the mixed-flow pump. At the same time, the noise dramatically increases. Overall speaking, the subtle variation of the inlet flow passage leads to a significant change of the mixed-flow pump performance, thus suggesting a special attention to the optimization of flow passage. This paper investigates the influence of the flow passage variation on the mixed-flow pump performance by experiment, which will benefit the optimal design of the flow passage of the mixed-flow pump.

Influence of system size and solvent flow on the distribution of wormlike micelles in a contraction-expansion geometry

NASA Astrophysics Data System (ADS)

Stukan, M. R.; Boek, E. S.; Padding, J. T.; Crawshaw, J. P.

2008-05-01

Viscoelastic wormlike micelles are formed by surfactants assembling into elongated cylindrical structures. These structures respond to flow by aligning, breaking and reforming. Their response to the complex flow fields encountered in porous media is particularly rich. Here we use a realistic mesoscopic Brownian Dynamics model to investigate the flow of a viscoelastic surfactant (VES) fluid through individual pores idealized as a step expansion-contraction of size around one micron. In a previous study, we assumed the flow field to be Newtonian. Here we extend the work to include the non-Newtonian flow field previously obtained by experiment. The size of the simulations is also increased so that the pore is much larger than the radius of gyration of the micelles. For the non-Newtonian flow field at the higher flow rates in relatively large pores, the density of the micelles becomes markedly non-uniform. In this case, we find that the density in the large, slowly moving entry corner regions is substantially increased.

48 CFR 46.309 - Research and development contracts (short form).

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Research and development contracts (short form). 46.309 Section 46.309 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Clauses 46.309 Research and development contracts...

No Snow No Flow: How Montane Stream Networks Respond to Drought

NASA Astrophysics Data System (ADS)

Grant, G.; Nolin, A. W.; Selker, J. S.; Lewis, S.; Hempel, L. A.; Jefferson, A.; Walter, C.; Roques, C.

2015-12-01

Hydrologic extremes, such as drought, offer an exceptional opportunity to explore how runoff generation mechanisms and stream networks respond to changing precipitation regimes. The winter of 2014-2015 was the warmest on record in western Oregon, US, with record low snowpacks, and was followed by an anomalously warm, dry spring, resulting in historically low streamflows. But a year like 2015 is more than an outlier meteorological year. It provides a unique opportunity to test fundamental hypotheses for how montane hydrologic systems will respond to anticipated changes in amount and timing of recharge. In particular, the volcanic Cascade Mountains represent a "landscape laboratory" comprised of two distinct runoff regimes: the surface-flow dominated Western Cascade watersheds, with flashy streamflow regimes, rapid baseflow recession, and very low summer flows; and (b) the spring-fed High Cascade watersheds, with a slow-responding streamflow regime, and a long and sustained baseflow recession that maintains late summer streamflow through deep-groundwater contributions to high volume, coldwater springs. We hypothesize that stream network response to the extremely low snowpack and recharge varies sharply in these two regions. In surface flow dominated streams, the location of channel heads can migrate downstream, contracting the network longitudinally; wetted channel width and depth contract laterally as summer recession proceeds and flows diminish. In contrast, in spring-fed streams, channel heads "jump" to the next downstream spring when upper basin spring flow diminishes to zero. Downstream of flowing springs, wetted channel width and depth contract laterally as flows recede. To test these hypotheses, we conducted a field campaign to measure changing discharge, hydraulic geometry, and channel head location in both types of watersheds throughout the summer and early fall. Multiple cross-section sites were established on 6 streams representing both flow regime types on either side of the Cascade crest. We also took Isotopic water samples to determine recharge elevations of receding streams. Taken together these measurements reveal the processes by which drainage networks contract as flows diminish - a fundamental property of montane stream systems both now and in the future.

Evaluation of a contraction flow field on hydrodynamic damage to entomopathogenic nematodes-A biological pest control agent.

PubMed

Fife, Jane P; Derksen, Richard C; Ozkan, H Erdal; Grewal, Parwinder S; Chalmers, Jeffrey J; Krause, Charles R

2004-04-05

Mechanized production and delivery of biological pesticides presents challenges because the biological agents must remain viable during these processes. This study evaluates the effect of flow through an abrupt contraction, where flow characteristics similar to that found within bioprocesses and spray equipment are developed, on damage to a benchmark biological pest control agent, entomopathogenic nematodes (EPNs). An opposed-pistons, contraction flow device generated volumetric flow rates ranging between 8.26 cm(3)/s and 41.3 cm(3)/s. Four EPN species were evaluated: Heterorhabditis bacteriophora, Heterorhabditis megidis, Steinernema carpocapsae, and Steinernema glaseri. Damage was quantified by counting living and dead EPNs. Optical and cold field emission scanning electron microscope (CFE-SEM) images provided qualitative information to describe how the damage occurred. The experimental flow field was completely described using FLUENT, a computational fluid dynamics program. Local flow parameters computed in FLUENT were compared to EPN damage. The type and extent of damage varied between EPN species. Damaged Heterorhabditis spp. generally remained whole with an internal rupture located near the center of the body, while Steinernema spp. most often broke into several pieces. The fast-transient stress field generated at the entrance to the contraction caused a momentary tensile loading and then relaxation that damaged the EPNs. At high flow rates, the tensile stresses became large enough to cause failure of the EPN structural membrane. The relative elasticity of the EPN structural membrane may explain the differences in damage observed between the species. It is speculated that the internal rupture of the Heterorhabditis spp. occurred during the processes of stretching and relaxing at the contraction entrance. Appreciable damage was observed at lower average energy dissipation rates for H. bacteriophora (1.23E + 8 W/m(3)), H. megidis (1.72E + 8 W/m(3)), and S. glaseri (2.89E + 8 W/m(3)) compared to S. carpocapsae (3.70E + 8 W/m(3)). Energy dissipation rates within an equipment component should be kept below 1E + 8 W/m(3) to avoid hydrodynamic damage to EPNs. The relationship between average energy dissipation and EPN damage provides important information for future simulation efforts of actual spray equipment components. Copyright 2004 Wiley Periodicals, Inc.

Option contracts for allocating water in inter-basin transfers: the case of the Tagus-Segura Transfer in Spain

NASA Astrophysics Data System (ADS)

Rey, Dolores; Garrido, Alberto; Calatraba, Javier

2014-05-01

Users in the Mediterranean region face significant water supply risks. Water markets mechanisms can provide flexibility to water systems run in tight situations. The largest water infrastructure in the Iberian Peninsula connects the Segura and Tagus Basins. Stakeholders and politicians in the Tagus Basin have asked that water transfers between the two basins be eventually phased out. The need to increase the statutory minimum environmental flow in the middle Tagus and to meet new urban demands is going to result in a redefinition of the Transfer's management rules, leading to a reduction in the transferable volumes. To minimise the consequences of such restrictions to irrigators in the Segura Basin who depend on the transferred volumes, we propose the establishment of water option contracts between both basins that represents an institutional innovation with respect to previous inter-basin spot market experiences. Based on the draft of the new Tagus Basin Plan, we propose both a modification of the Transfer's management rule and an innovative inter-basin option contract. The main goal of the paper is to define this contract and evaluate it with respect to non-market scenarios. We also assess the resulting impact on environmental flows in the Tagus River and water availability for users in the Segura Basin, together with the economic impacts of such contract on both basins. Our results show that the proposed option contract would reduce the impact of a change in the transfer's management rule, and reduce the supply risks of the recipient area. Keywords: environmental flow, inter-basin transfer, option contracts, Tagus-Segura, water markets, water supply reliability.

Random network peristalsis in Physarum polycephalum organizes fluid flows across an individual

PubMed Central

Alim, Karen; Amselem, Gabriel; Peaudecerf, François; Brenner, Michael P.; Pringle, Anne

2013-01-01

Individuals can function as integrated organisms only when information and resources are shared across a body. Signals and substrates are commonly moved using fluids, often channeled through a network of tubes. Peristalsis is one mechanism for fluid transport and is caused by a wave of cross-sectional contractions along a tube. We extend the concept of peristalsis from the canonical case of one tube to a random network. Transport is maximized within the network when the wavelength of the peristaltic wave is of the order of the size of the network. The slime mold Physarum polycephalum grows as a random network of tubes, and our experiments confirm peristalsis is used by the slime mold to drive internal cytoplasmic flows. Comparisons of theoretically generated contraction patterns with the patterns exhibited by individuals of P. polycephalum demonstrate that individuals maximize internal flows by adapting patterns of contraction to size, thus optimizing transport throughout an organism. This control of fluid flow may be the key to coordinating growth and behavior, including the dynamic changes in network architecture seen over time in an individual. PMID:23898203

Random network peristalsis in Physarum polycephalum organizes fluid flows across an individual.

PubMed

Alim, Karen; Amselem, Gabriel; Peaudecerf, François; Brenner, Michael P; Pringle, Anne

2013-08-13

Individuals can function as integrated organisms only when information and resources are shared across a body. Signals and substrates are commonly moved using fluids, often channeled through a network of tubes. Peristalsis is one mechanism for fluid transport and is caused by a wave of cross-sectional contractions along a tube. We extend the concept of peristalsis from the canonical case of one tube to a random network. Transport is maximized within the network when the wavelength of the peristaltic wave is of the order of the size of the network. The slime mold Physarum polycephalum grows as a random network of tubes, and our experiments confirm peristalsis is used by the slime mold to drive internal cytoplasmic flows. Comparisons of theoretically generated contraction patterns with the patterns exhibited by individuals of P. polycephalum demonstrate that individuals maximize internal flows by adapting patterns of contraction to size, thus optimizing transport throughout an organism. This control of fluid flow may be the key to coordinating growth and behavior, including the dynamic changes in network architecture seen over time in an individual.

48 CFR 1335.006 - Contracting methods and contract type.

Code of Federal Regulations, 2010 CFR

2010-10-01

... SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1335.006 Contracting methods and... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contracting methods and... research services under the contract might involve the use of human subjects. The provision is mandatory...

Aspects of research and development contract terms in the bio/pharmaceutical sector.

PubMed

Banerjee, Tannista

2012-01-01

The cost of new drug development is increasing every year. Pharmaceutical companies use R&D joint ventures, mergers, and outsource different stages of pharmaceutical R&D activities for a faster and cost minimizing method of innovation. Pharmaceutical companies outsource R&D activities to independent small biotech or pharmaceutical companies that specialize in different stages of pharmaceutical R&D. This chapter examines the determinants of the payment structure of research contracts between large bio/pharmaceutical companies and specialized research firms. Determinants of R&D contracts are analyzed using detailed R&D contract data between bio/pharmaceutical companies and independent research firms for 10 years. A multinomial logit model is used in order to understand the determinants of three different types of contracts; royalty contracts, fixed payment contracts, and the mixed contracts. Under uncertainty, the likelihood of a royalty contract rises for the early stages of the research and with the patent stock of the research firm. It is more likely to observe both royalty and fixed payment if the pharmaceutical client has past contracts with the same research firm. The results also suggest that if Food and Drug Administration (FDA) is more stringent in any disease area in reviewing the new drug application, then the likelihood of signing pure royalty contract decreases. Understanding the nature of R&D contracts and the effects of FDA's behavior on the pharmaceutical R&D contract is important because these contracts not only affect the cost of new drug invention but also the quality and the rate of invention. VALUE: Results are useful for both the pharmaceutical companies and the economic/business researchers.

Aeroacoustical Study of the Tgv Pantograph Recess

NASA Astrophysics Data System (ADS)

NOGER, C.; PATRAT, J. C.; PEUBE, J.; PEUBE, J. L.

2000-03-01

The general focus of this aerodynamic noise research, induced by turbulent incompressible flow, is to improve our knowledge of acoustic production mechanisms in the TGV pantograph recess in order to be able to reduce the radiated noise. This work is performed under contract with SNCF as a part of the German-French Cooperation DEUFRAKO K2, and is supported by French Ministries for Transport and Research. Previous studies on TGV noise source locations (DEUFRAKO K) have identified the pantograph recess as one of the important aerodynamic noise sources, for speeds higher than 300 km/h, due to flow separation. The pantograph recess is a very complex rectangular cavity, located both on the power car and the first coach roofs of the TGV, and has not been studied before due to the complex shapes. Its aeroacoustic features are investigated experimentally in a low-subsonic wind tunnel, on a realistic 1/7th scale mock-up both with and without pantographs. Flow velocities, estimated with hot-wire anemometry, and parietal visualizations show the flow to reattach on the recess bottom wall and to separate again at the downstream face. Wall pressure fluctuations and “acoustic” measurements using 14 and 12 in microphones respectively are also measured to qualify the flow: no aerodynamic or acoustic oscillations are observed. The study indicates that the pantograph recess has a different behaviour compared to the usual cavity grazing flows.

Process Improvement for Interinstitutional Research Contracting

PubMed Central

Logan, Jennifer; Bjorklund, Todd; Whitfield, Jesse; Reed, Peggy; Lesher, Laurie; Sikalis, Amy; Brown, Brent; Drollinger, Sandy; Larrabee, Kristine; Thompson, Kristie; Clark, Erin; Workman, Michael; Boi, Luca

2015-01-01

Abstract Introduction Sponsored research increasingly requires multiinstitutional collaboration. However, research contracting procedures have become more complicated and time consuming. The perinatal research units of two colocated healthcare systems sought to improve their research contracting processes. Methods The Lean Process, a management practice that iteratively involves team members in root cause analyses and process improvement, was applied to the research contracting process, initially using Process Mapping and then developing Problem Solving Reports. Results Root cause analyses revealed that the longest delays were the individual contract legal negotiations. In addition, the “business entity” was the research support personnel of both healthcare systems whose “customers” were investigators attempting to conduct interinstitutional research. Development of mutually acceptable research contract templates and language, chain of custody templates, and process development and refinement formats decreased the Notice of Grant Award to Purchase Order time from a mean of 103.5 days in the year prior to Lean Process implementation to 45.8 days in the year after implementation (p = 0.004). Conclusions The Lean Process can be applied to interinstitutional research contracting with significant improvement in contract implementation. PMID:26083433

Process Improvement for Interinstitutional Research Contracting.

PubMed

Varner, Michael; Logan, Jennifer; Bjorklund, Todd; Whitfield, Jesse; Reed, Peggy; Lesher, Laurie; Sikalis, Amy; Brown, Brent; Drollinger, Sandy; Larrabee, Kristine; Thompson, Kristie; Clark, Erin; Workman, Michael; Boi, Luca

2015-08-01

Sponsored research increasingly requires multiinstitutional collaboration. However, research contracting procedures have become more complicated and time consuming. The perinatal research units of two colocated healthcare systems sought to improve their research contracting processes. The Lean Process, a management practice that iteratively involves team members in root cause analyses and process improvement, was applied to the research contracting process, initially using Process Mapping and then developing Problem Solving Reports. Root cause analyses revealed that the longest delays were the individual contract legal negotiations. In addition, the "business entity" was the research support personnel of both healthcare systems whose "customers" were investigators attempting to conduct interinstitutional research. Development of mutually acceptable research contract templates and language, chain of custody templates, and process development and refinement formats decreased the Notice of Grant Award to Purchase Order time from a mean of 103.5 days in the year prior to Lean Process implementation to 45.8 days in the year after implementation (p = 0.004). The Lean Process can be applied to interinstitutional research contracting with significant improvement in contract implementation. © 2015 Wiley Periodicals, Inc.

Little Goose Dam Full Flow PIT-Tag Detection System Project Summary.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Warf, Don; Livingston, Scott

2009-04-16

In 2006, the design phase of this project was kicked off and was for the most part modeled after the Full Flow PIT installation installed at Lower Monumental Dam during winter and spring of 2006 and 2007. As the Goose Full Flow design progressed and the project started to move towards construction, issues within contracting occurred and the project was put on delay for 1 year. Starting in mid December of 2008, Harcon Inc. was awarded the contract and construction of the new Goose Full Flow PIT-tag detection system began. The purpose of this document is to summarize the installationmore » of the Little Goose Full Flow project from start to finish and to highlight the notable successes and challenges that the installation presented along with the final results and current status.« less

Doctor group sues to keep capitation arrangement.

PubMed

2005-05-01

An independent practice association has sued Humana Kansas City Inc. over the health plan's decision to terminate its capitated contract. The suit alleges breach of contract and seeks an injunction to keep the flow of capitated dollars coming.

The Contraction of Overlying Coronal Loop and the Rotating Motion of a Sigmoid Filament during Its Eruption

NASA Astrophysics Data System (ADS)

Yan, X. L.; Pan, G. M.; Liu, J. H.; Qu, Z. Q.; Xue, Z. K.; Deng, L. H.; Ma, L.; Kong, D. F.

2013-06-01

We present an observation of overlying coronal loop contraction and rotating motion of the sigmoid filament during its eruption on 2012 May 22 observed by the Solar Dynamics Observatory (SDO). Our results show that the twist can be transported into the filament from the lower atmosphere to the higher atmosphere. The successive contraction of the coronal loops was due to a suddenly reduced magnetic pressure underneath the filament, which was caused by the rising of the filament. Before the sigmoid filament eruption, there was a counterclockwise flow in the photosphere at the right feet of the filament and the contraction loops and a convergence flow at the left foot of the filament. The hot and cool materials have inverse motion along the filament before the filament eruption. Moreover, two coronal loops overlying the filament first experienced brightening, expansion, and contraction successively. At the beginning of the rising and rotation of the left part of the filament, the second coronal loop exhibited rapid contraction. The top of the second coronal loop also showed counterclockwise rotation during the contraction process. After the contraction of the second loop, the left part of the filament rotated counterclockwise and expanded toward the right of NOAA AR 11485. During the filament expansion, the right part of the filament also exhibited counterclockwise rotation like a tornado.

Micromixer based on viscoelastic flow instability at low Reynolds number.

PubMed

Lam, Y C; Gan, H Y; Nguyen, N T; Lie, H

2009-03-30

We exploited the viscoelasticity of biocompatible dilute polymeric solutions, namely, dilute poly(ethylene oxide) solutions, to significantly enhance mixing in microfluidic devices at a very small Reynolds number, i.e., Re approximately 0.023, but large Peclet and elasticity numbers. With an abrupt contraction microgeometry (8:1 contraction ratio), two different dilute poly(ethylene oxide) solutions were successfully mixed with a short flow length at a relatively fast mixing time of <10 mus. Microparticle image velocimetry was employed in our investigations to characterize the flow fields. The increase in velocity fluctuation with an increase in flow rate and Deborah number indicates the increase in viscoelastic flow instability. Mixing efficiency was characterized by fluorescent concentration measurements. Our results showed that enhanced mixing can be achieved through viscoelastic flow instability under situations where molecular-diffusion and inertia effects are negligible. This approach bypasses the laminar flow limitation, usually associated with a low Reynolds number, which is not conducive to mixing.

Micromixer based on viscoelastic flow instability at low Reynolds number

PubMed Central

Lam, Y. C.; Gan, H. Y.; Nguyen, N. T.; Lie, H.

2009-01-01

We exploited the viscoelasticity of biocompatible dilute polymeric solutions, namely, dilute poly(ethylene oxide) solutions, to significantly enhance mixing in microfluidic devices at a very small Reynolds number, i.e., Re≈0.023, but large Peclet and elasticity numbers. With an abrupt contraction microgeometry (8:1 contraction ratio), two different dilute poly(ethylene oxide) solutions were successfully mixed with a short flow length at a relatively fast mixing time of <10 μs. Microparticle image velocimetry was employed in our investigations to characterize the flow fields. The increase in velocity fluctuation with an increase in flow rate and Deborah number indicates the increase in viscoelastic flow instability. Mixing efficiency was characterized by fluorescent concentration measurements. Our results showed that enhanced mixing can be achieved through viscoelastic flow instability under situations where molecular-diffusion and inertia effects are negligible. This approach bypasses the laminar flow limitation, usually associated with a low Reynolds number, which is not conducive to mixing. PMID:19693399

48 CFR 2035.70 - Contract clauses.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 2035.70 Contract clauses. (a) The contracting officer shall insert the following clause in all solicitations and contracts for research and development by private contractors and universities and for other technical services, as appropriate: (1) Section 2052.235-70...

U.S. Coast Guard 1994 Oil Pollution Research Grants Publications - Part I.

DTIC Science & Technology

1996-09-01

11. Contract or Grant No. John A. Volpe National Transportation Systems Center Cambridge, MA 02142 13. Type of Report and Period Covered 12...thickening of the slick. An increase in slick thickness beyond the barrier draft d leads to drainage failure. Cross and Hoult (1971) studied the...Froude number of the flow upstream of the slick exceeds a critical value (0.498-0.527). The frontal region of the slick is thus analogous to a hydraulic

48 CFR 46.307 - Fixed-price research and development contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Clauses 46.307 Fixed-price research and development... Development—Fixed-Price, in solicitations and contracts for research and development when (1) the primary... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Fixed-price research and...

Post-emplacement cooling and contraction of lava flows: InSAR observations and thermal model for lava fields at Hekla volcano, Iceland

NASA Astrophysics Data System (ADS)

Wittmann, Werner; Dumont, Stephanie; Lavallee, Yan; Sigmundsson, Freysteinn

2016-04-01

Gradual post-emplacement subsidence of lava flows has been observed at various volcanoes, e.g. Okmok volcano in Alaska, Kilauea volcano on Hawaii and Etna volcano on Sicily. In Iceland, this effect has been observed at Krafla volcano and Hekla volcano. The latter was chosen as a case study for investigating subsidence mechanisms, specifically thermal contraction. Effects like gravitational loading, clast repacking or creeping of a hot and liquid core can contribute to subsidence of emplaced lava flows, but thermal contraction is considered being a crucial effect. The extent to which it contributes to lava flow subsidence is investigated by mapping the relative movement of emplaced lava flows and flow substrate, and modeling the observed signal. The slow vegetation in Iceland is advantageous for Interferometric Synthetic Aperture Radar (InSAR) and offers great coherence over long periods after lava emplacement, expanding beyond the outlines of lava flows. Due to this reason, InSAR observations over volcanoes in Iceland have taken place for more than 20 years. By combining InSAR tracks from ERS, Envisat and Cosmo-SkyMed satellites we gain six time series with a total of 99 interferograms. Making use of the high spatial resolution, a temporal trend of vertical lava movements was investigated over a course of over 23 years over the 1991 lava flow of Hekla volcano, Iceland. From these time series, temporal trends of accumulated subsidence and subsidence velocities were determined in line of sight of the satellites. However, the deformation signal of lava fields after emplacement is vertically dominated. Subsidence on this lava field is still ongoing and subsidence rates vary from 14.8 mm/year in 1995 to about 1.0 mm/year in 2014. Fitting a simple exponential function suggests a exponential decay constant of 5.95 years. Additionally, a one-dimensional, semi-analytical model was fitted to these data. While subsidence due to phase change is calculated analytically, subsidence due to thermal contraction gives additional subsidence, which is calculated numerically. Inversions were carried out for initial lava thickness, thermal expansivity, thermal diffusivity, latent heat and specific heat as the crucial parameters governing lava flow subsidence.

Use of a Scale Model in the Design of Modifications to the NASA Glenn Icing Research Tunnel

NASA Technical Reports Server (NTRS)

Canacci, Victor A.; Gonsalez, Jose C.; Spera, David A.; Burke, Thomas (Technical Monitor)

2001-01-01

Major modifications were made in 1999 to the 6- by 9-Foot (1.8- by 2.7-m) Icing Research tunnel (IRT) at the NASA Glenn Research Center, including replacement of its heat exchanger and associated ducts and turning vanes, and the addition of fan outlet guide vanes (OGV's). A one-tenth scale model of the IRT (designated as the SMIRT) was constructed with and without these modifications and tested to increase confidence in obtaining expected improvements in flow quality around the tunnel loop. The SMIRT is itself an aerodynamic test facility whose flow patterns without modifications have been shown to be accurate, scaled representations of those measured in the IRT prior to the 1999 upgrade program. In addition, tests in the SMIRT equipped with simulated OGV's indicated that these devices in the IRT might reduce flow distortions immediately downstream of the fan by two thirds. Flow quality parameters measured in the SMIRT were projected to the full-size modified IRT, and quantitative estimates of improvements in flow quality were given prior to construction. In this paper, the results of extensive flow quality studies conducted in the SMIRT are documented. Samples of these are then compared with equivalent measurements made in the full-scale IRT, both before and after its configuration was upgraded. Airspeed, turbulence intensity, and flow angularity distributions are presented for cross sections downstream of the drive fan, both upstream and downstream of the replacement flat heat exchanger, in the stilling chamber, in the test section, and in the wakes of the new comer turning vanes with their unique expanding and contracting designs. Lessons learned from these scale-model studies are discussed.

Small-Gap Flows

DTIC Science & Technology

1984-04-01

I TV N 4 NAVAL ARCIETUR & OFFSHORE ENGINEERING SMALL- GAP FLOWSti E 0.TUCK01 REPORT NO- M!AOL 34-1 CONTRACT NJU1-𔃾-K-0026 APRIL 1984 let.? UNIVERSMn...34’OF CALIFORNIA# BERKELEY, CA 5.1720 ft (45 642-141 SMALL- GAP FLOWS BY E. 0. TUCK REPORT No. NAUE 84-1 CONTRACT N00014-84-K-OU26 APRIL i984...34small- gap " theme.Chapters 1-4 were originally presented in the form of a lecture series in the Department of Naval Architecture and Offshore

Active Flow Control in an Aggressive Transonic Diffuser

NASA Astrophysics Data System (ADS)

Skinner, Ryan W.; Jansen, Kenneth E.

2017-11-01

A diffuser exchanges upstream kinetic energy for higher downstream static pressure by increasing duct cross-sectional area. The resulting stream-wise and span-wise pressure gradients promote extensive separation in many diffuser configurations. The present computational work evaluates active flow control strategies for separation control in an asymmetric, aggressive diffuser of rectangular cross-section at inlet Mach 0.7 and Re 2.19M. Corner suction is used to suppress secondary flows, and steady/unsteady tangential blowing controls separation on both the single ramped face and the opposite flat face. We explore results from both Spalart-Allmaras RANS and DDES turbulence modeling frameworks; the former is found to miss key physics of the flow control mechanisms. Simulated baseline, steady, and unsteady blowing performance is validated against experimental data. Funding was provided by Northrop Grumman Corporation, and this research used resources of the Argonne Leadership Computing Facility, which is a DOE Office of Science User Facility supported under Contract DE-AC02-06CH11357.

Flow and Transport of Fines in Dams and Embankments

NASA Astrophysics Data System (ADS)

Glascoe, L. G.; Ezzedine, S. M.; Kanarska, Y.; Lomov, I.; Antoun, T.; Woodson, S. C.; Hall, R. L.; Smith, J.

2013-12-01

Understanding the flow of fines in porous media and fractured media is significant for industrial, environmental, geotechnical and petroleum technologies to name a few. Several models have been proposed to simulate the flow and transport of fines using single or two-phase flow approaches while other models rely on mobile and immobile transport approaches. However, to the authors' best knowledge, all the proposed modeling approaches have not been compared to each other in order to define their limitations and domain of validation. In the present study, several models describing the transport of fines in heterogeneous porous and fractured media will be presented and compared to each other. Furthermore, we will evaluate their performance on the same published experimental sets of published data. This work performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344 and was sponsored by the Department of Homeland Security (DHS), Science and Technology Directorate, Homeland Security Advanced Research Projects Agency (HSARPA).

Sensor Systems Collect Critical Aerodynamics Data

NASA Technical Reports Server (NTRS)

2010-01-01

With the support of Small Business Innovation Research (SBIR) contracts with Dryden Flight Research Center, Tao of Systems Integration Inc. developed sensors and other components that will ultimately form a first-of-its-kind, closed-loop system for detecting, measuring, and controlling aerodynamic forces and moments in flight. The Hampton, Virginia-based company commercialized three of the four planned components, which provide sensing solutions for customers such as Boeing, General Electric, and BMW and are used for applications such as improving wind turbine operation and optimizing air flow from air conditioning systems. The completed system may one day enable flexible-wing aircraft with flight capabilities like those of birds.

Hydrodynamic Contributions to Amoeboid Cell Motility

NASA Astrophysics Data System (ADS)

Lewis, Owen; Guy, Robert

2011-11-01

Understanding the methods by which cells move is a fundamental problem in modern biology. Recent evidence has shown that the fluid dynamics of cytoplasm can play a vital role in cellular motility. The slime mold Physarum polycephalum provides an excellent model organism for the study of amoeboid motion. In this research, we use both analytic and computational models to investigate intracellular fluid flow in a simple model of Physarum. In both models, of we are specifically interested in stresses generated by cytoplasmic flow which act in the direction of cellular motility. In our numerical model, the Immersed Boundary Method is used to account for such stresses. We investigate the relationship between contraction waves, low waves and locomotive forces, and attempt characterize conditions necessary to generate directed motion.

Challenges With Research Contract Negotiations in Community-Based Cancer Research.

PubMed

Thompson, Michael A; Hurley, Patricia A; Faller, Bryan; Longinette, Jean; Richter, Katie; Stewart, Teresa L; Robert, Nicholas

2016-06-01

Community-based research programs face many barriers to participation in clinical trials. Although the majority of people with cancer are diagnosed and treated in the community setting, only roughly 3% are enrolled onto clinical trials. Research contract and budget negotiations have been consistently identified as time consuming and a barrier to participation in clinical trials. ASCO's Community Research Forum conducted a survey about specific challenges of research contract and budget negotiation processes in community-based research settings. The goal was to ultimately identify potential solutions to these barriers. A survey was distributed to 780 community-based physician investigators and research staff. The survey included questions to provide insight into contract and budget negotiation processes and perceptions about related barriers. A total of 77% of the 150 respondents acknowledged barriers in the process. Respondents most frequently identified budget-related issues (n = 133), inefficiencies in the process (n = 80), or legal review and negotiation issues (n = 70). Of the respondents, 44.1% indicated that contract research organizations made the contract negotiations process harder for their research program, and only 5% believed contract research organizations made the process easier. The contract negotiations process is perceived to be impeded by sponsors through underestimation of costs, lack of flexibility with the contract language, and excessive delays. Improving clinical trial activation processes and reducing inefficiencies would be beneficial to all interested stakeholders, including patients who may ultimately stand to benefit from participation in clinical trials. The following key recommendations were made: standardization of contracts and negotiation processes to promulgate transparency and efficiencies, improve sponsor processes to minimize burden on sites, create and promote use of contract templates and best practices, and provide education and consultation. Copyright © 2016 by American Society of Clinical Oncology.

48 CFR 235.072 - Additional contract clauses.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 252.235-7011, Final Scientific or Technical Report, in solicitations and contracts for research and... SYSTEM, DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 235... involving research on live vertebrate animals. (b) Use the clause at 252.235-7003, Frequency Authorization...

48 CFR 235.072 - Additional contract clauses.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 252.235-7011, Final Scientific or Technical Report, in solicitations and contracts for research and... SYSTEM, DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 235... involving research on live vertebrate animals. (b) Use the clause at 252.235-7003, Frequency Authorization...

Effects of radial direction and eccentricity on acceleration perception.

PubMed

Mueller, Alexandra S; Timney, Brian

2014-01-01

Radial optic flow can elicit impressions of self-motion--vection--or of objects moving relative to the observer, but there is disagreement as to whether humans have greater sensitivity to expanding or to contracting optic flow. Although most studies agree there is an anisotropy in sensitivity to radial optic flow, it is unclear whether this asymmetry is a function of eccentricity. The issue is further complicated by the fact that few studies have examined how acceleration sensitivity is affected, even though observers and objects in the environment seldom move at a constant speed. To address these issues, we investigated the effects of direction and eccentricity on the ability to detect acceleration in radial optic flow. Our results indicate that observers are better at detecting acceleration when viewing contraction compared with expansion and that eccentricity has no effect on the ability to detect accelerating radial optic flow. Ecological interpretations are discussed.

Simulation of dilute polymeric fluids in a three-dimensional contraction using a multiscale FENE model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Griebel, M., E-mail: griebel@ins.uni-bonn.de, E-mail: ruettgers@ins.uni-bonn.de; Rüttgers, A., E-mail: griebel@ins.uni-bonn.de, E-mail: ruettgers@ins.uni-bonn.de

The multiscale FENE model is applied to a 3D square-square contraction flow problem. For this purpose, the stochastic Brownian configuration field method (BCF) has been coupled with our fully parallelized three-dimensional Navier-Stokes solver NaSt3DGPF. The robustness of the BCF method enables the numerical simulation of high Deborah number flows for which most macroscopic methods suffer from stability issues. The results of our simulations are compared with that of experimental measurements from literature and show a very good agreement. In particular, flow phenomena such as a strong vortex enhancement, streamline divergence and a flow inversion for highly elastic flows are reproduced.more » Due to their computational complexity, our simulations require massively parallel computations. Using a domain decomposition approach with MPI, the implementation achieves excellent scale-up results for up to 128 processors.« less

Implementation of Good Clinical Laboratory Practice (GCLP) guidelines within the External Quality Assurance Program Oversight Laboratory (EQAPOL).

PubMed

Todd, Christopher A; Sanchez, Ana M; Garcia, Ambrosia; Denny, Thomas N; Sarzotti-Kelsoe, Marcella

2014-07-01

The EQAPOL contract was awarded to Duke University to develop and manage global proficiency testing programs for flow cytometry-, ELISpot-, and Luminex bead-based assays (cytokine analytes), as well as create a genetically diverse panel of HIV-1 viral cultures to be made available to National Institutes of Health (NIH) researchers. As a part of this contract, EQAPOL was required to operate under Good Clinical Laboratory Practices (GCLP) that are traditionally used for laboratories conducting endpoint assays for human clinical trials. EQAPOL adapted these guidelines to the management of proficiency testing programs while simultaneously incorporating aspects of ISO/IEC 17043 which are specifically designed for external proficiency management. Over the first two years of the contract, the EQAPOL Oversight Laboratories received training, developed standard operating procedures and quality management practices, implemented strict quality control procedures for equipment, reagents, and documentation, and received audits from the EQAPOL Central Quality Assurance Unit. GCLP programs, such as EQAPOL, strengthen a laboratory's ability to perform critical assays and provide quality assessments of future potential vaccines. © 2013.

An Evaluation of Bioregulators/Modulators as Terrorism and Warfare Agents

DTIC Science & Technology

2003-07-01

such as bronchial and vascular tone and muscle contraction . This opens an unprecedented possibility to use toxic substances that could not be...bronchial smooth muscles and also in the intestines and the uterus bradykinin leads to muscle contraction . Bradykinin is also one the most potent...gout. Bradykinin has a powerful influence in stimulating smooth muscle contraction , inducing hypotension, increasing blood flow and permeability of

Experimental study of the free surface velocity field in an asymmetrical confluence

NASA Astrophysics Data System (ADS)

Creelle, Stephan; Mignot, Emmanuel; Schindfessel, Laurent; De Mulder, Tom

2017-04-01

The hydrodynamic behavior of open channel confluences is highly complex because of the combination of different processes that interact with each other. To gain further insights in how the velocity uniformization between the upstream channels and the downstream channel is proceeding, experiments are performed in a large scale 90 degree angled concrete confluence flume with a chamfered rectangular cross-section and a width of 0.98m. The dimensions and lay-out of the flume are representative for a prototype scale confluence in e.g. drainage and irrigation systems. In this type of engineered channels with sharp corners the separation zone is very large and thus the velocity difference between the most contracted section and the separation zone is pronounced. With the help of surface particle tracking velocimetry the velocity field is recorded from upstream of the confluence to a significant distance downstream of the confluence. The resulting data allow to analyze the evolution of the incoming flows (with a developed velocity profile) that interact with the stagnation zone and each other, causing a shear layer between the two bulk flows. Close observation of the velocity field near the stagnation zone shows that there are actually two shear layers in the vicinity of the upstream corner. Furthermore, the data reveals that the shear layer observed more downstream between the two incoming flows is actually one of the two shear layers next to the stagnation zone that continues, while the other shear layer ceases to exist. The extensive measurement domain also allows to study the shear layer between the contracted section and the separation zone. The shear layers of the stagnation zone between the incoming flows and the one between the contracted flow and separation zone are localized and parameters such as the maximum gradient, velocity difference and width of the shear layer are calculated. Analysis of these data shows that the shear layer between the incoming flows disappears quite quickly, because of the severe flow contraction that aids the flow uniformization. This is also accelerated because of a flow redistribution process that starts already upstream of the confluence, resulting in a lower than expected velocity difference over the shear layer between the bulk of the incoming flows. In contrast, the shear layer between the contracted section and the separation zone proves to be of a significantly higher order of magnitude, with large turbulent structures appearing that get transported far downstream. In conclusion, the resulting understanding of this analysis of velocity fields with a larger field of view shows that when analyzing confluence hydrodynamics, one should pay ample attention to analyze data far enough up and downstream to assess all the relevant processes.

Contracting in vivo research: what are the issues?

PubMed

Underwood, Wendy J

2007-07-01

As a result of increasing internal and external pressures, research institutions are using contract research organizations for the conduct of in vivo research. Many issues arise when contracting animal research, including concern regarding animal health and welfare. Each sponsor institution should develop a program for outsourced in vivo research that evaluates and ensures appropriate care and use of research animals. Each sponsoring institution should consider establishing a policy and procedure for how outsourced in vivo studies will be approved, conducted, and monitored. An approved list of contract facilities can be established on the basis of accepted standards for animal care and use. Written contracts should include confidentiality agreements, the delineation of animal ownership, and the expectation to comply with all applicable regulations and guidelines for research animal care and use. Finally, a process for communication of adverse study or animal welfare events should be established. Thorough evaluation of contract organizations will help ensure appropriate research animal care and use.

No effect of NOS inhibition on skeletal muscle glucose uptake during in situ hindlimb contraction in healthy and diabetic Sprague-Dawley rats.

PubMed

Hong, Yet Hoi; Betik, Andrew C; Premilovac, Dino; Dwyer, Renee M; Keske, Michelle A; Rattigan, Stephen; McConell, Glenn K

2015-05-15

Nitric oxide (NO) has been shown to be involved in skeletal muscle glucose uptake during contraction/exercise, especially in individuals with Type 2 diabetes (T2D). To examine the potential mechanisms, we examined the effect of local NO synthase (NOS) inhibition on muscle glucose uptake and muscle capillary blood flow during contraction in healthy and T2D rats. T2D was induced in Sprague-Dawley rats using a combined high-fat diet (23% fat wt/wt for 4 wk) and low-dose streptozotocin injections (35 mg/kg). Anesthetized animals had one hindlimb stimulated to contract in situ for 30 min (2 Hz, 0.1 ms, 35 V) with the contralateral hindlimb rested. After 10 min, the NOS inhibitor, N(G)-nitro-l-arginine methyl ester (l-NAME; 5 μM) or saline was continuously infused into the femoral artery of the contracting hindlimb until the end of contraction. Surprisingly, there was no increase in skeletal muscle NOS activity during contraction in either group. Local NOS inhibition had no effect on systemic blood pressure or muscle contraction force, but it did cause a significant attenuation of the increase in femoral artery blood flow in control and T2D rats. However, NOS inhibition did not attenuate the increase in muscle capillary recruitment during contraction in these rats. Muscle glucose uptake during contraction was significantly higher in T2D rats compared with controls but, unlike our previous findings in hooded Wistar rats, NOS inhibition had no effect on glucose uptake during contraction. In conclusion, NOS inhibition did not affect muscle glucose uptake during contraction in control or T2D Sprague-Dawley rats, and this may have been because there was no increase in NOS activity during contraction. Copyright © 2015 the American Physiological Society.

Comparative 1D and 3D numerical investigation of open-channel junction flows and energy losses

NASA Astrophysics Data System (ADS)

Luo, Hao; Fytanidis, Dimitrios K.; Schmidt, Arthur R.; García, Marcelo H.

2018-07-01

The complexity of open channel confluences stems from flow mixing, secondary circulation, post-confluence flow separation, contraction and backwater effects. These effects in turn result in a large number of parameters required to adequately quantify the junction induced hydraulic resistance and describe mean flow pattern and turbulent flow structures due to flow merging. The recent development in computing power advances the application of 3D Computational Fluid Dynamics (CFD) codes to visualize and understand the Confluence Hydrodynamic Zone (CHZ). Nevertheless, 1D approaches remain the mainstay in large drainage network or waterway system modeling considering computational efficiency and data availability. This paper presents (i) a modified 1D nonlinear dynamic model; (ii) a fully 3D non-hydrostatic, Reynolds-averaged Navier-Stokes Equations (RANS)-based, Computational Fluid Dynamics (CFD) model; (iii) an analysis of changing confluence hydrodynamics and 3D turbulent flow structure under various controls; (iv) a comparison of flow features (i.e. upstream water depths, energy losses and post-confluence contraction) predicted by 1D and 3D models; and (v) parameterization of 3D flow characteristics in 1D modeling through the computation of correction coefficients associated with contraction, energy and momentum. The present comprehensive 3D numerical investigation highlights the driving mechanisms for junction induced energy losses. Moreover, the comparative 1D and 3D study quantifies the deviation of 1D approximations and associated underlying assumptions from the 'true' resultant flow field. The study may also shed light on improving the accuracy of the 1D large network modeling through the parameterization of the complex 3D feature of the flow field and correction of interior boundary conditions at junctions of larger angles and/or with substantial lateral inflows. Moreover, the enclosed numerical investigations may enhance the understanding of the primary mechanisms contributing to hydraulic structure induced turbulent flow behavior and increased hydraulic resistance.

Migratory beekeeping practices contribute insignificantly to transgenic pollen flow among fields of alfalfa produced for seed

USDA-ARS?s Scientific Manuscript database

Increased use of genetically engineered crops in agriculture has raised concerns over pollinator-mediated gene flow between transgenic and conventional agricultural varieties. This study evaluated whether contracted migratory beekeeping practices influence transgenic pollen flow among spatially iso...

Flow Rate Driven by Peristaltic Movement in Plasmodial Tube of Physarum Polycephalum

NASA Astrophysics Data System (ADS)

Yamada, Hiroyasu; Nakagaki, Toshiyuki

2008-07-01

We report a theoretical analysis of protoplasmic streaming driven by peristaltic movement in an elastic tube of an amoeba-like organism. The Plasmodium of Physarum polycephalum, a true slime mold, is a large amoeboid organism that adopts a sheet-like form with a tubular network. The network extends throughout the Plasmodium and enables the transport and circulation of chemical signals and nutrients. This tubular flow is driven by periodically propagating waves of active contraction of the tube cortex, a process known as peristaltic movement. We derive the relationship between the phase velocity of the contraction wave and the flow rate, and we discuss the physiological implications of this relationship.

Dynamics of near-surface electric discharges and mechanisms of their interaction with the airflow

NASA Astrophysics Data System (ADS)

Leonov, Sergey B.; Adamovich, Igor V.; Soloviev, Victor R.

2016-12-01

The main focus of the review is on dynamics and kinetics of near-surface discharge plasmas, such as surface dielectric barrier discharges sustained by AC and repetitively pulsed waveforms, pulsed DC discharges, and quasi-DC discharges, generated in quiescent air and in the airflow. A number of technical issues related to plasma flow control applications are discussed in detail, including discharge development via surface ionization waves, charge transport and accumulation on dielectric surface, discharge contraction, different types of flow perturbations generated by surface discharges, and effect of high-speed flow on discharge dynamics. In the first part of the manuscript, plasma morphology and results of electrical and optical emission spectroscopy measurements are discussed. Particular attention is paid to dynamics of surface charge accumulation and dissipation, both in diffuse discharges and during development of ionization instabilities resulting in discharge contraction. Contraction leads to significant increase of both the surface area of charge accumulation and the energy coupled to the plasma. The use of alternating polarity pulse waveforms accelerates contraction of surface dielectric barrier discharges and formation of filamentary plasmas. The second part discusses the interaction of discharge plasmas with quiescent air and the external airflow. Four major types of flow perturbations have been identified: (1) low-speed near-surface jets generated by electrohydrodynamic interaction (ion wind); (2) spanwise and streamwise vortices formed by both electrohydrodynamic and thermal effects; (3) weak shock waves produced by rapid heating in pulsed discharges on sub-microsecond time scale; and (4) near-surface localized stochastic perturbations, on sub-millisecond time, detected only recently. The mechanism of plasma-flow interaction remains not fully understood, especially in filamentary surface dielectric barrier discharges. Localized quasi-DC surface discharges sustained in a high-speed flow are discussed in the third part of the review. Although dynamics of this type of the discharge is highly transient, due to its strong interaction with the flow, the resultant flow structure is stationary, including the oblique shock and the flow separation region downstream of the discharge. The oblique shock is attached to a time-averaged, wedge-shaped, near-wall plasma layer, with the shock angle controlled by the discharge power, which makes possible changing the flow structure and parameters in a controlled way. Finally, unresolved and open-ended issues are discussed in the summary.

THE CONTRACTION OF OVERLYING CORONAL LOOP AND THE ROTATING MOTION OF A SIGMOID FILAMENT DURING ITS ERUPTION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yan, X. L.; Qu, Z. Q.; Xue, Z. K.

We present an observation of overlying coronal loop contraction and rotating motion of the sigmoid filament during its eruption on 2012 May 22 observed by the Solar Dynamics Observatory (SDO). Our results show that the twist can be transported into the filament from the lower atmosphere to the higher atmosphere. The successive contraction of the coronal loops was due to a suddenly reduced magnetic pressure underneath the filament, which was caused by the rising of the filament. Before the sigmoid filament eruption, there was a counterclockwise flow in the photosphere at the right feet of the filament and the contractionmore » loops and a convergence flow at the left foot of the filament. The hot and cool materials have inverse motion along the filament before the filament eruption. Moreover, two coronal loops overlying the filament first experienced brightening, expansion, and contraction successively. At the beginning of the rising and rotation of the left part of the filament, the second coronal loop exhibited rapid contraction. The top of the second coronal loop also showed counterclockwise rotation during the contraction process. After the contraction of the second loop, the left part of the filament rotated counterclockwise and expanded toward the right of NOAA AR 11485. During the filament expansion, the right part of the filament also exhibited counterclockwise rotation like a tornado.« less

48 CFR 252.215-7002 - Cost estimating system requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... customers in the expectation of receiving contract awards. Estimating system includes the Contractor's— (1... and managerial reviews; (4) Flow of work, coordination, and communication; and (5) Budgeting, planning... writing, its rationale for disagreeing. (3) The Contracting Officer will evaluate the Contractor's...

48 CFR 252.215-7002 - Cost estimating system requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... customers in the expectation of receiving contract awards. Estimating system includes the Contractor's— (1... and managerial reviews; (4) Flow of work, coordination, and communication; and (5) Budgeting, planning... writing, its rationale for disagreeing. (3) The Contracting Officer will evaluate the Contractor's...

Contract Research, the University, and the Academic.

ERIC Educational Resources Information Center

Crawshaw, Bruce

1985-01-01

Implications of the growth of university-based contract research are examined, including moral and ethical issues, legal aspects, ownership of research results, staff rights, researcher status, publication, authority, responsibility, social justice, and conflicts between teaching and research. Eleven suggestions for successful contract research…

48 CFR 27.406-2 - Additional data requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

..., research, or demonstration contracts, it may not be feasible to ascertain all the data requirements at... basic or applied research to be performed under a contract solely by a university or college when the... research to be performed by a university or college, and the contracting officer believes the contract...

48 CFR 27.406-2 - Additional data requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

..., research, or demonstration contracts, it may not be feasible to ascertain all the data requirements at... basic or applied research to be performed under a contract solely by a university or college when the... research to be performed by a university or college, and the contracting officer believes the contract...

Investigations of flowfields found in typical combustor geometries

NASA Technical Reports Server (NTRS)

Lilley, D. G.

1984-01-01

Studies are concerned with experimental and theoretical research on 2-D axisymmetric geometries under low speed, nonreacting, turbulent, swirling flow conditions. The flow enters the test section and proceeds into a larger chamber (the linear expansion ratio D/d = 2, 1.5 and 1) via a sudden or gradual expansion (side wall angle alpha = 90 and 45 degrees). A weak or strong nozzle (of area ratio A/a = 2 and 4) may be positioned downstream at x/D = 2 to form a contraction exit to the test section. Inlet swirl vanes are adjustable to a variety of vane angles with values of theta = 0, 38, 45, 60 and 70 degrees being emphasized. The objective is to determine the effect of these parameters on isothermal flow field patterns, time mean velocities and turbulence quantities, and to establish an improved simulation in the form of a computer prediction code equipped with a suitable turbulence model. The goal of the on going research is to perform experiments and complementary computations with the idea of doing the necessary type of research that will yield improved calculation capability. This involves performing experiments where time mean turbulence quantities are measured and taking input conditions and running an existing prediction code for a variety of test cases so as to compare predictions against experiment.

48 CFR 10.003 - Contract clause.

Code of Federal Regulations, 2011 CFR

2011-10-01

... MARKET RESEARCH 10.003 Contract clause. The contracting officer shall insert the clause at 52.210-1, Market Research, in solicitations and contracts over $5 million for the procurement of items other than...

48 CFR 232.072-3 - Cash flow forecasts.

Code of Federal Regulations, 2013 CFR

2013-10-01

... forecasts is a strong indicator of serious managerial deficiencies or potential contract cost or performance... the causes of any differences. (d) Cash flow forecasts must— (1) Show the origin and use of all...

48 CFR 232.072-3 - Cash flow forecasts.

Code of Federal Regulations, 2011 CFR

2011-10-01

... forecasts is a strong indicator of serious managerial deficiencies or potential contract cost or performance... the causes of any differences. (d) Cash flow forecasts must— (1) Show the origin and use of all...

48 CFR 232.072-3 - Cash flow forecasts.

Code of Federal Regulations, 2014 CFR

2014-10-01

... forecasts is a strong indicator of serious managerial deficiencies or potential contract cost or performance... the causes of any differences. (d) Cash flow forecasts must— (1) Show the origin and use of all...

48 CFR 232.072-3 - Cash flow forecasts.

Code of Federal Regulations, 2012 CFR

2012-10-01

... forecasts is a strong indicator of serious managerial deficiencies or potential contract cost or performance... the causes of any differences. (d) Cash flow forecasts must— (1) Show the origin and use of all...

Submerged flow bridge scour under clear water conditions

DOT National Transportation Integrated Search

2012-09-01

Prediction of pressure flow (vertical contraction) scour underneath a partially or fully submerged bridge superstructure : in an extreme flood event is crucial for bridge safety. An experimentally and numerically calibrated formulation is : developed...

48 CFR 252.215-7002 - Cost estimating system requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... customers in the expectation of receiving contract awards. Estimating system includes the Contractor's— (1... and managerial reviews; (4) Flow of work, coordination, and communication; and (5) Budgeting, planning... for disagreeing. (3) The Contracting Officer will evaluate the Contractor's response and notify the...

Spatial mapping reveals multi-step pattern of wound healing in Physarum polycephalum

NASA Astrophysics Data System (ADS)

Bäuerle, Felix K.; Kramar, Mirna; Alim, Karen

2017-11-01

Wounding is a severe impairment of function, especially for an exposed organism like the network-forming true slime mould Physarum polycephalum. The tubular network making up the organism’s body plan is entirely interconnected and shares a common cytoplasm. Oscillatory contractions of the enclosing tube walls drive the shuttle streaming of the cytoplasm. Cytoplasmic flows underlie the reorganization of the network for example by movement toward attractive stimuli or away from repellants. Here, we follow the reorganization of P. polycephalum networks after severe wounding. Spatial mapping of the contraction changes in response to wounding reveal a multi-step pattern. Phases of increased activity alternate with cessation of contractions and stalling of flows, giving rise to coordinated transport and growth at the severing site. Overall, severing surprisingly acts like an attractive stimulus enabling healing of severed tubes. The reproducible cessation of contractions arising during this wound-healing response may open up new venues to investigate the biochemical wiring underlying P. polycephalum’s complex behaviours.

Stratiform clouds and their interaction with atmospheric motion

NASA Technical Reports Server (NTRS)

Clark, John H. E.; Shirer, Hampton N.

1990-01-01

During 1989 and 1990, the researchers saw the publication of two papers and the submission of a third for review on work supported primarily by the previous contract, NAS8-36150; the delivery of an invited talk at the SIAM Conference on Dynamical Systems in Orlando, Florida; and the start of two new projects on the radiative effects of stratocumulus on the large-scale flow. The published papers discuss aspects of stratocumulus circulations (Laufersweiler and Shirer, 1989) and the Hadley to Rossby regime transition in rotating spherical systems (Higgins and Shirer, 1990). The submitted paper (Haack and Shirer, 1990) discusses a new nonlinear model of roll circulations that are forced both dynamically and thermally. The invited paper by H. N. Shirer and R. Wells presented an objective means for determining appropriate truncation levels for low-order models of flows involving two incommensurate periods; this work has application to the Hadley to Rossby transition problem in quasi-geostrophic flows (Moroz and Holmes, 1984). The new projects involve the development of a multi-layered quasi-geostrophic channel model for study of the modulation of the large-scale flow by stratocumulus clouds that typically develop off the coasts of continents. In this model the diabatic forcing in the lowest layer will change in response to the (parameterized) development of extensive fields of stratocumulus clouds. To guide creation of this parameterization scheme, researchers are producing climatologies of stratocumulus frequency and the authors correlate these frequencies with the phasing and amplitude of the large-scale flow pattern. Researchers discuss the above topics in greater detail.

On Driving AGB Mass-Loss from Core-Contraction

NASA Astrophysics Data System (ADS)

Lewis, B. M.

1997-12-01

A bulk movement of mass constitutes a momentum flow. An instructive instance occurs in the radial pulsation of stars and white dwarfs, where a symmetric contraction phase implies the existence of an inwardly- directed radial momentum flow, that is followed during the subsequent expansion by an outwardly-directed flow. The key notion here is that an inward flow is effectively transmitted through the center to become in turn an outward flow: in adiabatic processes the momentum flux is not cancelled simply because it arrives at the center. However, during the radial pulsation of AGB stars momentum is cancelled in atmospheric shock-waves and consumed in work against gravity while mass is lifted far enough away from the star for dust to form, whereon radiation pressure drives it away. These momentum-dissipative conditions at the outer boundary therefore require a stellar source of radially directed momentum if pulsation is to continue in an AGB star. A sufficient source is found in the contraction of the whole of the electron-degenerate core of an AGB star under the addition of He ashes from shell-hydrogen burning. This produces an inwardly- directed radial momentum flow that must reach the center. Lewis quantifies the resulting momentum flux (http://xxx.lanl.gov/ps/astro-ph /9707233), and finds that it easily suffices to support the mass-loss of every AGB star. But it is necessary to assume that most of the inwardly directed flux is transmitted through the center to become in turn an outwardly directed flux. The AGB core maintains its virial equilibrium by exporting its excess momentum flux to the stellar envelope. This mechanism explains the dependence of the mass-loss rate from AGB stars on core mass; its generalization to objects with angular momentum and/or strong magnetic fields suggests a novel explanation for the axial symmetry exhibited by most planetary nebulae and proto planetary nebulae. Gravitational contraction can also account for the momentum flux in the solar wind.

First-order approximation for the pressure-flow relationship of spontaneously contracting lymphangions.

PubMed

Quick, Christopher M; Venugopal, Arun M; Dongaonkar, Ranjeet M; Laine, Glen A; Stewart, Randolph H

2008-05-01

To return lymph to the great veins of the neck, it must be actively pumped against a pressure gradient. Mean lymph flow in a portion of a lymphatic network has been characterized by an empirical relationship (P(in) - P(out) = -P(p) + R(L)Q(L)), where P(in) - P(out) is the axial pressure gradient and Q(L) is mean lymph flow. R(L) and P(p) are empirical parameters characterizing the effective lymphatic resistance and pump pressure, respectively. The relation of these global empirical parameters to the properties of lymphangions, the segments of a lymphatic vessel bounded by valves, has been problematic. Lymphangions have a structure like blood vessels but cyclically contract like cardiac ventricles; they are characterized by a contraction frequency (f) and the slopes of the end-diastolic pressure-volume relationship [minimum value of resulting elastance (E(min))] and end-systolic pressure-volume relationship [maximum value of resulting elastance (E(max))]. Poiseuille's law provides a first-order approximation relating the pressure-flow relationship to the fundamental properties of a blood vessel. No analogous formula exists for a pumping lymphangion. We therefore derived an algebraic formula predicting lymphangion flow from fundamental physical principles and known lymphangion properties. Quantitative analysis revealed that lymph inertia and resistance to lymph flow are negligible and that lymphangions act like a series of interconnected ventricles. For a single lymphangion, P(p) = P(in) (E(max) - E(min))/E(min) and R(L) = E(max)/f. The formula was tested against a validated, realistic mathematical model of a lymphangion and found to be accurate. Predicted flows were within the range of flows measured in vitro. The present work therefore provides a general solution that makes it possible to relate fundamental lymphangion properties to lymphatic system function.

Role of positive urethrovesical feedback in vesical evacuation. The concept of a second micturition reflex: the urethrovesical reflex.

PubMed

Shafik, Ahmed; Shafik, Ali A; El-Sibai, Olfat; Ahmed, Ismail

2003-08-01

Upon feeling the urge to urinate, the urinary bladder contracts, the urethral sphincters relax and urine flows through the urethra. These actions are mediated by the micturition reflex. We investigated the hypothesis that vesical contraction is maintained by positive feedback through continuous flow of urine through the urethra, and that the cessation of urine flow aborts detrusor contraction. Normal saline was infused into the urinary bladders of 17 healthy volunteers (age 35.2 years+/-4.2(SD); ten women and seven men) at a rate of 100 ml/min. On urge, which occurred at a mean volume of 408.6 ml+/-28.7 of saline, the subject micturated while the vesical and urethral pressures during voiding were being recorded; residual urine was measured. The test was repeated after anesthetizing the urethra with xylocaine gel or, on another occasion, after applying a bland gel. On micturition, the urine was evacuated as a continuous stream without straining; no residual fluid was collected. After urethral anesthetization, the fluid came out of the urethra in multiple intermittent spurts and only with excessive straining. There was a large amount of residual fluid (184.6 ml+/-28.4). The results of bland gel application showed no significant difference ( P>0.05) from those without gel. Detrusor contraction during micturition is suggested to be maintained by positive urethrovesical feedback elicited by the continued passage of urine through the urethra. This feedback seems to be effected through the urethrovesical reflex, which produces vesical contraction on stimulation of the urethral stretch receptors. Abortion of this reflex by urethral anesthetization resulted in failure of detrusor contraction and excessive straining was needed to achieve bladder evacuation in multiple spurts. The urethrovesical reflex is thus assumed to constitute a second micturition reflex responsible for the continuation of detrusor contraction and urination. The role of this reflex in the pathogenesis of micturition disorders needs to be studied.

United States Navy Contracting Officer Warranting Process

DTIC Science & Technology

2011-03-01

by 30% or more of the respondents: Contract Law , Cost Analysis, Market Research, Contract Source Selection, Simplified Acquisition Procedures, and...that the majority of AOs found the following course at least somewhat important: Contract Law , Cost Analysis, Market Research, Contract 52 Source...the budget and appropriation cycle 4. Ethics and conduct standards 5. Basic contract laws and regulations 6. Socio-economic requirements in

Computations of Chaotic Flows in Micromixers

DTIC Science & Technology

2005-01-01

2005 2. REPORT TYPE 3. DATES COVERED 00-00-2005 to 00-00-2005 4. TITLE AND SUBTITLE Computations of Chaotic Flows in Micromixers 5a. CONTRACT...Std Z39-18 215simulation, computing, and modeling 2005 NRL Review Computations of Chaotic Flows In Micromixers FIGURE 6 Schematic of staggered

Streambed stability and scour potential at selected bridge sites in Michigan

USGS Publications Warehouse

Holtschlag, D.J.; Miller, R.L.

1998-01-01

Contraction scour in the main stream channel at a bridge and local scour near piers and abutments can result in bridge failure. Estimates of contraction-scour and local-scour potentials associated with the 100-year flood were computed for 13 bridge sites in Michigan by use of semi-theoretical equations and procedures recommended by the Federal Highway Administration. These potentials were compared with measures of Streambed stability obtained by use of data from 773 historical streamflow measurements, documenting 20,741 individual Streambed soundings between 1959 and 1995. Analysis of these data indicate small, but statistically significant, monotonic trends in Streambed elevation at 10 sites. No consistent patterns in relations between changes in Streambed elevations and streamflow, flow velocity, or flow depth were evident. Also, estimates of contraction-scour potential were not correlated with measures of Streambed stability, and no differences were detected between measures of Streambed stability in the main channel and stability adjacent to piers. Despite the inconsistencies between measures of Streambed stability and scour potential, data from a single, large flood (greater than a 100-year event) provided field evidence that the relation between scour and streamflow is highly nonlinear. This nonlinearity and the limited availability of measurements of extreme flood events may have reduced the utility of the empirical measures for confirming the nonlinear scour-potential equations and procedures. Results of field surveys using ground-penetrating radar and tuned transducers showed limited ability to aid interpretation of historical scour conditions at four bridge sites. Additional research is needed to confirm the applicability of scour-potential equations for hydrogeologic conditions in Michigan.

48 CFR 235.015-70 - Special use allowances for research facilities acquired by educational institutions.

Code of Federal Regulations, 2013 CFR

2013-10-01

..., acquired for the purpose of conducting scientific research under contracts with departments and agencies of... research facilities acquired by educational institutions. 235.015-70 Section 235.015-70 Federal Acquisition... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 235.015-70 Special use allowances for research facilities...

48 CFR 235.015-70 - Special use allowances for research facilities acquired by educational institutions.

Code of Federal Regulations, 2012 CFR

2012-10-01

..., acquired for the purpose of conducting scientific research under contracts with departments and agencies of... research facilities acquired by educational institutions. 235.015-70 Section 235.015-70 Federal Acquisition... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 235.015-70 Special use allowances for research facilities...

48 CFR 235.015-70 - Special use allowances for research facilities acquired by educational institutions.

Code of Federal Regulations, 2014 CFR

2014-10-01

..., acquired for the purpose of conducting scientific research under contracts with departments and agencies of... research facilities acquired by educational institutions. 235.015-70 Section 235.015-70 Federal Acquisition... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 235.015-70 Special use allowances for research facilities...

Development of Laser Velocimetry for the Measurements of Turbulence Intensity and Flow Velocity Ahead of a NGV Row in a Full-Stage Rotating Turbine

DTIC Science & Technology

1993-09-01

INTRODUCTION This document represents a letter final report for the Caispan UB Research Center ( CUBRC ) contract no. F33615-85-C-2566. There have been many...was that CUBRC would design, construct, and calibrate heat-flux gage inserts for the Advanced High Work Turbine (AHWT) vane which is the next...Row in a Full-Stage Rotating Turbine (Unsolicited Proposal No. 102)" is herein incorporated by reference. The CUBRC proposal to which SECTION C refers

Aquatic Habitat Studies on the Lower Mississippi River, River Mile 480 to 530. Report 7. Management of Ecological Data in Large River Ecosystems.

DTIC Science & Technology

1982-02-01

operational. Many times at the startup of a project, variable selection and research data formats are often tentative because of the unknown biological...previously. This flow of data is shown in Figure 1. ELPROGI also made quality control decisions; when a variable for a given observation failed a...a series MENT OF ECOLOGICAL DATA IN LARGE RIVER ECOSYSTEMS s. PERFORMING ONG. REPORT NUMBER 7. AUTNOlt.s) S. CONTRACT O GRANT N UNMSE-) Michael P

Further Insight into the Reaction FeO+ + H2 Yields Fe+ + H2O: Temperature Dependent Kinetics, Isotope Effects, and Statistical Modeling (Postprint)

DTIC Science & Technology

2014-07-31

a laminar flow tube via a Venturi inlet, where ∼104 to 105 collisions with a He buffer gas act to thermalize the ions and carry them downstream...ISOTOPE EFFECTS , AND STATISTICAL MODELING (POSTPRINT) Shaun G. Ard, et al. 31 July 2014 Journal Article AIR FORCE RESEARCH LABORATORY Space Vehicles...Kinetics, Isotope Effects , and Statistical Modeling (Postprint) 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 61102F 6

Convection and macrosegregation in Al-19Cu alloy directionally solidified through an abrupt contraction in cross-section: A comparison with Al-7Si

NASA Astrophysics Data System (ADS)

Ghods, M.; Lauer, M.; Grugel, R. N.; Tewari, S. N.; Poirier, D. R.

2017-02-01

Hypoeutectic Al-19 wt. % Cu alloys were directionally solidified in cylindrical molds that featured an abrupt cross-section decrease 9.5 to 3.2 mm in diameter). Thermo-solutal convection and cross-section-change-induced shrinkage flow effects on macrosegregation were investigated. Dendrite clustering and extensive radial macrosegregation was seen, particularly in the larger cross-section before contraction. This alloy shows positive longitudinal macrosegregation near the contraction followed by negative macrosegregation right after it; the extent of macrosegregation, however, decreases with increasing growth speed. The degree of thermo-solutal convection was compared to another study investigating directional solidification of Al-7 wt. % Si [1] in order to study the effect of solutal expansion coefficient on macrosegregation. An interesting change of the radial macrosegregation profile, attributable to the area-change-induced-shrinkage flow, was observed very close to the contraction. A two-dimensional model accounting for both shrinkage and thermo-solutal convection was used to simulate solidification, the resulting steepling as well as axial and radial macrosegregation. The experimentally observed macrosegregation associated with the contraction during directional solidification was well predicted by the numerical simulations.

Numerical determination of personal aerosol sampler aspiration efficiency.

PubMed

Lo Savio, Simone; Paradisi, Paolo; Tampieri, Francesco; Belosi, Franco; Morigi, Maria Pia; Agostini, Sergio

2003-04-01

In this work the determination of the aspiration efficiency of personal aerosol samplers, commonly used in occupational exposure assessment, is investigated by means of CFD techniques. Specifically, it will be described a code to calculate the particle trajectories in a given flow field. At the present state the code considers only the effects of the mean flow field on the particle motion, whereas the turbulent diffusion effects are neglected. Comparisons with experimental measurements are also given in the framework of a research contract, supported by the European Community, with several experimental contributions from the participants. The main objective of the European research is to develop a new approach to experimentation with airborne particle flows, working on a reduced scale. This methodology has the advantage of allowing real-time aerosol determination and use of small wind tunnels, with a better experimental control. In this article we describe how the methodology has been verified using computational fluid dynamics. Experimental and numerical aspiration efficiencies have been compared and the influence of gravity and turbulence intensity in full and reduced scale has been investigated. The numerical techniques described here are in agreement with previous similar research and allow at least qualitative predictions of aspiration efficiency for real samplers, taking care of orientation from the incoming air flow. The major discrepancies among predicted and experimental results may be a consequence of bounce effects, which are very difficult to eliminate also by greasing the sampler surface.

Report on Contractual Flow Down Provisions in the Federal Acquisition Regulation (FAR) and Defense Federal Acquisition Regulation Supplement (DFARS)

DTIC Science & Technology

2017-11-01

Richard Ginman, A Study of the Applicability of Federal Acquisition Regulation (FAR) Clauses to Subcontracts under Prime Defense and NASA Contracts...publication, A Study of the Applicability of Federal Acquisition Regulation (FAR) Clauses to Subcontracts under Prime Defense and NASA Contracts, http...FAR) Clauses to Subcontracts under Prime Defense and NASA Contracts. Arlington, VA: National Defense Industrial Association NDIA), 2016. http

Sensors for Environmental Control

NASA Technical Reports Server (NTRS)

1996-01-01

Under a Kennedy Space Center Small Business Innovation Research contract, GEO-CENTERS, Inc. developed a sensing element or 'optrode,' which NASA needed for space life support research to measure a hydroponic culture's pH factor. The company then commercialized the technology in the PC Based pH Monitoring System. The system employs the optrode to enable long term continuous monitoring of the pH level of fluids in standing and flowing conditions, an optoelectronic board with light sensors and detectors that fits into a desktop computer, and a fiber optic cable that connects the two. The system is effective in monitoring the pH output of industries to maintain ranges acceptable to the Environmental Protection Agency.

Muscle contraction duration and fibre recruitment influence blood flow and oxygen consumption independent of contractile work during steady-state exercise in humans.

PubMed

Richards, Jennifer C; Crecelius, Anne R; Kirby, Brett S; Larson, Dennis G; Dinenno, Frank A

2012-06-01

We tested the hypothesis that, among conditions of matched contractile work, shorter contraction durations and greater muscle fibre recruitment result in augmented skeletal muscle blood flow and oxygen consumption ( ) during steady-state exercise in humans. To do so, we measured forearm blood flow (FBF; Doppler ultrasound) during 4 min of rhythmic hand-grip exercise in 24 healthy young adults and calculated forearm oxygen consumption ( ) via blood samples obtained from a catheter placed in retrograde fashion into a deep vein draining the forearm muscle. In protocol 1 (n = 11), subjects performed rhythmic isometric hand-grip exercise at mild and moderate intensities during conditions in which time-tension index (isometric analogue of work) was held constant but contraction duration was manipulated. In this protocol, shorter contraction durations led to greater FBF (184 ± 25 versus 164 ± 25 ml min(-1)) and (23 ± 3 versus 17 ± 2 ml min(-1); both P < 0.05) among mild workloads, whereas this was not the case for moderate-intensity exercise. In protocol 2 (n = 13), subjects performed rhythmic dynamic hand-grip exercise at mild and moderate intensities in conditions of matched total work, but muscle fibre recruitment was manipulated. In this protocol, greater muscle fibre recruitment led to significantly greater FBF (152 ± 15 versus 127 ± 13 ml min(-1)) and (20 ± 2 versus 17 ± 2 ml min(-1); both P < 0.05) at mild workloads, and there was a trend for similar responses at the moderate intensity but this was not statistically significant. In both protocols, the ratio of the change in FBF to change in was similar across all exercise intensities and manipulations, and the strongest correlation among all variables was between and blood flow. Our collective data indicate that, among matched workloads, shorter contraction duration and greater muscle fibre recruitment augment FBF and during mild-intensity forearm exercise, and that muscle blood flow is more closely related to metabolic cost ( ) rather than contractile work per se during steady-state exercise in humans.

Fundamental Structure of High-Speed Reacting Flows: Supersonic Combustion and Detonation

DTIC Science & Technology

2016-04-30

AFRL-AFOSR-VA-TR-2016-0195 Fundamental Structure of High-Speed Reacting Flows: Supersonic Combustion and Detonation Kenneth Yu MARYLAND UNIV COLLEGE...MARCH 2016 4. TITLE AND SUBTITLE FUNDAMENTAL STRUCTURE OF HIGH-SPEED REACTING FLOWS: SUPERSONIC COMBUSTION AND DETONATION 5a. CONTRACT NUMBER...public release. Final Report on Fundamental Structure of High-Speed Reacting Flows: Supersonic Combustion and Detonation Grant

Mach 10 experimental database of a three-dimensional scramjet inlet flow field

NASA Technical Reports Server (NTRS)

Holland, Scott D.

1995-01-01

The present work documents the experimental database of a combined computational and experimental parametric study of the internal aerodynamics of a generic three-dimensional sidewall compression scramjet inlet configuration at Mach 10. A total of 356 channels of pressure data, including static pressure orifices, pitot pressures, and exit flow rakes, along with oil flow and infrared thermography, provided a detailed experimental description of the flow. Mach 10 tests were performed for three geometric contraction ratios (3, 5, and 9), three Reynolds numbers (0.55 x 10(exp 6) per foot, 1.14 x 10(exp 6) per foot, and 2.15 x 10(exp 6) per foot), and three cowl positions (at the throat and two forward positions). For the higher contraction ratios, a large forward separation of the inflow boundary layer was observed, making the high contraction ratio configurations unsuitable for flight operation. A decrease in the freestream unit Reynolds number (Re) of only a factor of 2 led to a similar upstream separation. Although the presence of such large-scale separations leads to the question of whether the inlet is started, the presence of internal oblique swept shock interactions on the sidewalls seems to indicate that at least in the classical sense, the inlet is not unstarted. The laminar inflow boundary layer therefore appears to be very sensitive to increases in contraction ratio (CR) or decreases in Reynolds number; only the CR = 3 configuration with 0.25, and 50 percent cowl at Re = 2.15 x 10(exp 6) per foot operated 'on design'.

Level II scour analysis for Bridge 4 (CRAFTH00040004) on Town Highway 4, crossing Whitney Brook, Craftsbury, Vermont

USGS Publications Warehouse

Boehmler, Erick M.; Hammond, Robert E.

1996-01-01

Total scour at a highway crossing is comprised of three components: 1) long-term degradation; 2) contraction scour (due to accelerated flow caused by reduction in flow area at a bridge) and; 3) local scour (caused by accelerated flow around piers and abutments). Total scour is the sum of the three components. Equations are available to compute depths for contraction and local scour and a summary of the computed scour results follow. Contraction scour for all modelled flows ranged from 0.7 to 1.7 feet. The worst-case contraction scour occurred at the 500-year discharge. Abutment scour ranged from 10.7 to 15.3 feet. The worst-case abutment scour also occurred at the 500-year discharge. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A cross-section of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1995, p. 47). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

48 CFR 15.604 - Agency points of contact.

Code of Federal Regulations, 2010 CFR

2010-10-01

... agency: upcoming solicitations; Broad Agency Announcements; Small Business Innovation Research programs; Small Business Technology Transfer Research programs; Program Research and Development Announcements; or... CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Unsolicited Proposals 15.604 Agency points...

An Analytical-Numerical Model for Two-Phase Slug Flow through a Sudden Area Change in Microchannels

DOE PAGES

Momen, A. Mehdizadeh; Sherif, S. A.; Lear, W. E.

2016-01-01

In this article, two new analytical models have been developed to calculate two-phase slug flow pressure drop in microchannels through a sudden contraction. Even though many studies have been reported on two-phase flow in microchannels, considerable discrepancies still exist, mainly due to the difficulties in experimental setup and measurements. Numerical simulations were performed to support the new analytical models and to explore in more detail the physics of the flow in microchannels with a sudden contraction. Both analytical and numerical results were compared to the available experimental data and other empirical correlations. Results show that models, which were developed basedmore » on the slug and semi-slug assumptions, agree well with experiments in microchannels. Moreover, in contrast to the previous empirical correlations which were tuned for a specific geometry, the new analytical models are capable of taking geometrical parameters as well as flow conditions into account.« less

Heat and mass transfer analysis of unsteady MHD nanofluid flow through a channel with moving porous walls and medium

NASA Astrophysics Data System (ADS)

Zubair Akbar, Muhammad; Ashraf, Muhammad; Farooq Iqbal, Muhammad; Ali, Kashif

2016-04-01

The paper presents the numerical study of heat and mass transfer analysis in a viscous unsteady MHD nanofluid flow through a channel with porous walls and medium in the presence of metallic nanoparticles. The two cases for effective thermal conductivity are discussed in the analysis through H-C model. The impacts of the governing parameters on the flow, heat and mass transfer aspects of the issue are talked about. Under the patronage of small values of permeable Reynolds number and relaxation/contraction parameter, we locate that, when wall contraction is together with suction, flow turning is encouraged close to the wall where the boundary layer is shaped. On the other hand, when the wall relaxation is coupled with injection, the flow adjacent to the porous walls decreased. The outcome of the exploration may be beneficial for applications of biotechnology. Numerical solutions for the velocity, heat and mass transfer rate at the boundary are obtained and analyzed.

Development of analytical methods of predicting the pressure distribution about a nacelle at transonic speeds: Exact solution

NASA Technical Reports Server (NTRS)

Grossman, B.; Moretti, G.

1973-01-01

A computer program to predict the inviscid, transonic flow field about isolated nacelles was developed. The problem was to be formulated to solve Euler's equations without any approximation (such as small disturbances) and hence the terminology exact solution. The flow field was complicated by the presence of imbedded shock waves, an engine-inlet interface, and exhaust plumes. Furthermore, the transonic nacelles of interest had a very slender but blunt cowl lip. This created two distinct length scales, the length of the nacelle and the cowl lip radius that can differ by several orders of magnitude. These aspects of the flow field presented many numerical difficulties. The approach to the problem was to calculate the nacelle flow field using the method of time-dependent computations (TDC). Although at the time of the issuance of this contract, other approaches to transonic flow calculations existed, it was felt that TDC offered the most effective means of meeting the goals of the contract.

Erosion of water-based fracturing fluid containing particles in a sudden contraction of horizontal pipe

NASA Astrophysics Data System (ADS)

Cheng, Jiarui; Cao, Yinping; Dou, Yihua; Li, Zhen

2017-10-01

A lab experiment was carried out to study the effects of pipe flow rate, particle concentration and pipe inner diameter ratio on proppant erosion of the reducing wall in hydraulic fracturing. The results show that the erosion rate and erosion distribution are different not only in radial direction but also in circumferential direction of the sample. The upper part of sample always has a minimum erosion rate and erosion area. Besides, the erosion rate of reducing wall is most affected by fluid flow velocity, and the erosion area is most sensitive to the change in the diameter ratio. Meanwhile, the erosion rate of reducing wall in crosslinked fracturing fluid is mainly determined by the fluid flowing state due to the high viscosity of the liquid. In general, the increase in flow velocity and diameter ratio not only cause the expansion of erosion-affected flow region in sudden contraction section, but also lead to more particles impact the wall.

Feedback between intracellular flow, signaling and active stresses in Physarum plasmodial fragments

NASA Astrophysics Data System (ADS)

Zhang, Shun; Guy, Robert; Del Alamo, Juan Carlos

2016-11-01

Physarum polycephalum is a multinucleated slime mold whose endoplasm flows periodically driven by the contraction of its ectoplasm, a dense shell of F-actin cross-linked by myosin molecular motors and attached to the cell membrane. Ectoplasm contractions are regulated by calcium ions whose propagation is in turn governed by the flow. We study experimentally how this feedback leads to auto-oscillation by simultaneously measuring endoplasmic flow speed and rheological properties, the traction stresses between the ectoplasm and its substratum and the distribution of endoplasmic free calcium ions. We find that physarum fragments smaller than 100 microns remain round and stay in place. However, larger fragments break symmetry leading to sustained forward locomotion, in process that is reminiscent of an interfacial instability that seems to settle around two different limit cycles (traveling waves and standing waves). By using different adhesive coatings in the substratum we investigate the role of substratum friction in the emergence of coherent endoplasmic flow patterns and overall physarum fragment locomotion.

48 CFR 11.503 - Contract clauses.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., Liquidated Damages—Supplies, Services, or Research and Development, in fixed-price solicitations and contracts for supplies, services, or research and development when the contracting officer determines that...—Construction, in solicitations and contracts for construction, other than cost-plus-fixed-fee, when the...

Study of Spray Disintegration in Accelerating Flow Fields

NASA Technical Reports Server (NTRS)

Nurick, W. H.

1972-01-01

An analytical and experimental investigation was conducted to perform "proof of principlem experiments to establish the effects of propellant combustion gas velocity on propella'nt atomization characteristics. The propellants were gaseous oxygen (GOX) and Shell Wax 270. The fuel was thus the same fluid used in earlier primary cold-flow atomization studies using the frozen wax method. Experiments were conducted over a range in L* (30 to 160 inches) at two contraction ratios (2 and 6). Characteristic exhaust velocity (c*) efficiencies varied from SO to 90 percent. The hot fire experimental performance characteristics at a contraction ratio of 6.0 in conjunction with analytical predictions from the drovlet heat-up version of the Distributed Energy Release (DER) combustion computer proDam showed that the apparent initial dropsize compared well with cold-flow predictions (if adjusted for the gas velocity effects). The results also compared very well with the trend in perfomnce as predicted with the model. significant propellant wall impingement at the contraction ratio of 2.0 precluded complete evaluation of the effect of gross changes in combustion gas velocity on spray dropsize.

Finite-element simulation of blood perfusion in muscle tissue during compression and sustained contraction.

PubMed

Vankan, W J; Huyghe, J M; Slaaf, D W; van Donkelaar, C C; Drost, M R; Janssen, J D; Huson, A

1997-09-01

Mechanical interaction between tissue stress and blood perfusion in skeletal muscles plays an important role in blood flow impediment during sustained contraction. The exact mechanism of this interaction is not clear, and experimental investigation of this mechanism is difficult. We developed a finite-element model of the mechanical behavior of blood-perfused muscle tissue, which accounts for mechanical blood-tissue interaction in maximally vasodilated vasculature. Verification of the model was performed by comparing finite-element results of blood pressure and flow with experimental measurements in a muscle that is subject to well-controlled mechanical loading conditions. In addition, we performed simulations of blood perfusion during tetanic, isometric contraction and maximal vasodilation in a simplified, two-dimensional finite-element model of a rat calf muscle. A vascular waterfall in the venous compartment was identified as the main cause for blood flow impediment both in the experiment and in the finite-element simulations. The validated finite-element model offers possibilities for detailed analysis of blood perfusion in three-dimensional muscle models under complicated loading conditions.

48 CFR 242.7001 - Contract clause.

Code of Federal Regulations, 2014 CFR

2014-10-01

... solicitations and contracts (other than in contracts with educational institutions, Federally Funded Research and Development Centers (FFRDCs), or University Associated Research Centers (UARCs) operated by...

48 CFR 242.7001 - Contract clause.

Code of Federal Regulations, 2013 CFR

2013-10-01

... solicitations and contracts (other than in contracts with educational institutions, Federally Funded Research and Development Centers (FFRDCs), or University Associated Research Centers (UARCs) operated by...

48 CFR 242.7001 - Contract clause.

Code of Federal Regulations, 2012 CFR

2012-10-01

... solicitations and contracts (other than in contracts with educational institutions, Federally Funded Research and Development Centers (FFRDCs), or University Associated Research Centers (UARCs) operated by...

Reduced order modeling and active flow control of an inlet duct

NASA Astrophysics Data System (ADS)

Ge, Xiaoqing

Many aerodynamic applications require the modeling of compressible flows in or around a body, e.g., the design of aircraft, inlet or exhaust duct, wind turbines, or tall buildings. Traditional methods use wind tunnel experiments and computational fluid dynamics (CFD) to investigate the spatial and temporal distribution of the flows. Although they provide a great deal of insight into the essential characteristics of the flow field, they are not suitable for control analysis and design due to the high physical/computational cost. Many model reduction methods have been studied to reduce the complexity of the flow model. There are two main approaches: linearization based input/output modeling and proper orthogonal decomposition (POD) based model reduction. The former captures mostly the local behavior near a steady state, which is suitable to model laminar flow dynamics. The latter obtains a reduced order model by projecting the governing equation onto an "optimal" subspace and is able to model complex nonlinear flow phenomena. In this research we investigate various model reduction approaches and compare them in flow modeling and control design. We propose an integrated model-based control methodology and apply it to the reduced order modeling and active flow control of compressible flows within a very aggressive (length to exit diameter ratio, L/D, of 1.5) inlet duct and its upstream contraction section. The approach systematically applies reduced order modeling, estimator design, sensor placement and control design to improve the aerodynamic performance. The main contribution of this work is the development of a hybrid model reduction approach that attempts to combine the best features of input/output model identification and POD method. We first identify a linear input/output model by using a subspace algorithm. We next project the difference between CFD response and the identified model response onto a set of POD basis. This trajectory is fit to a nonlinear dynamical model to augment the linear input/output model. Thus, the full system is decomposed into a dominant linear subsystem and a low order nonlinear subsystem. The hybrid model is then used for control design and compared with other modeling methods in CFD simulations. Numerical results indicate that the hybrid model accurately predicts the nonlinear behavior of the flow for a 2D diffuser contraction section model. It also performs best in terms of feedback control design and learning control. Since some outputs of interest (e.g., the AIP pressure recovery) are not observable during normal operations, static and dynamic estimators are designed to recreate the information from available sensor measurements. The latter also provides a state estimation for feedback controller. Based on the reduced order models and estimators, different controllers are designed to improve the aerodynamic performance of the contraction section and inlet duct. The integrated control methodology is evaluated with CFD simulations. Numerical results demonstrate the feasibility and efficacy of the active flow control based on reduced order models. Our reduced order models not only generate a good approximation of the nonlinear flow dynamics over a wide input range, but also help to design controllers that significantly improve the flow response. The tools developed for model reduction, estimator and control design can also be applied to wind tunnel experiment.

Microfluidic flows of wormlike micellar solutions.

PubMed

Zhao, Ya; Cheung, Perry; Shen, Amy Q

2014-09-01

The widespread use of wormlike micellar solutions is commonly found in household items such as cosmetic products, industrial fluids used in enhanced oil recovery and as drag reducing agents, and in biological applications such as drug delivery and biosensors. Despite their extensive use, there are still many details about the microscopic micellar structure and the mechanisms by which wormlike micelles form under flow that are not clearly understood. Microfluidic devices provide a versatile platform to study wormlike micellar solutions under various flow conditions and confined geometries. A review of recent investigations using microfluidics to study the flow of wormlike micelles is presented here with an emphasis on three different flow types: shear, elongation, and complex flow fields. In particular, we focus on the use of shear flows to study shear banding, elastic instabilities of wormlike micellar solutions in extensional flow (including stagnation and contraction flow field), and the use of contraction geometries to measure the elongational viscosity of wormlike micellar solutions. Finally, we showcase the use of complex flow fields in microfluidics to generate a stable and nanoporous flow-induced structured phase (FISP) from wormlike micellar solutions. This review shows that the influence of spatial confinement and moderate hydrodynamic forces present in the microfluidic device can give rise to a host of possibilities of microstructural rearrangements and interesting flow phenomena. Copyright © 2014 Elsevier B.V. All rights reserved.

Vasodilatory effect of L-arginine on isolated rabbit and human posterior ciliary arteries in vitro and increased optic disc blood flow in vivo.

PubMed

Chuman, Hideki; Sugimoto, Takako; Nao-I, Nobuhisa

2017-12-01

This study aimed to clarify the vasodilatory effect of L-arginine on isolated rabbit and human posterior ciliary arteries (PCAs) and to investigate changes in optic disc blood flow after an infusion of L-arginine in vivo. Vascular ring segments were mounted on a double myograph system. After obtaining maximal contraction following administration of high-K solution, L-arginine was administrated. Six volunteers received an intravenous drip infusion of 100 ml of L-arginine or saline. Changes in optic disc blood flow were measured by laser speckle flowgraphy. L-arginine relaxed high-K solution-induced contracted rabbit PCAs. Carboxy-PTIO (nitric oxide scavenger) and L-NAME (nitric oxide synthase inhibitor) inhibited L-arginine-induced relaxation in rabbit PCAs. After removal of the endothelium of the rabbit PCAs, L-arginine still relaxed rabbit PCAs. L-arginine relaxed human PCAs, despite the lack of nitric oxide production. In the L-arginine infusion group, the mean blur rate was significantly greater than that of the control group in vivo. L-arginine has both nitric oxide-dependent and independent vasodilatory effect on high K- induced contractions in isolated rabbit and human PCAs. L-arginine increased optic disc blood flow in vivo.

Droplet Breakup in Expansion-contraction Microchannels

PubMed Central

Zhu, Pingan; Kong, Tiantian; Lei, Leyan; Tian, Xiaowei; Kang, Zhanxiao; Wang, Liqiu

2016-01-01

We investigate the influences of expansion-contraction microchannels on droplet breakup in capillary microfluidic devices. With variations in channel dimension, local shear stresses at the injection nozzle and focusing orifice vary, significantly impacting flow behavior including droplet breakup locations and breakup modes. We observe transition of droplet breakup location from focusing orifice to injection nozzle, and three distinct types of recently-reported tip-multi-breaking modes. By balancing local shear stresses and interfacial tension effects, we determine the critical condition for breakup location transition, and characterize the tip-multi-breaking mode quantitatively. In addition, we identify the mechanism responsible for the periodic oscillation of inner fluid tip in tip-multi-breaking mode. Our results offer fundamental understanding of two-phase flow behaviors in expansion-contraction microstructures, and would benefit droplet generation, manipulation and design of microfluidic devices. PMID:26899018

Cardiac torsion and electromagnetic fields: the cardiac bioinformation hypothesis.

PubMed

Burleson, Katharine O; Schwartz, Gary E

2005-01-01

Although in physiology the heart is often referred to as a simple piston pump, there are in fact two additional features that are integral to cardiac physiology and function. First, the heart as it contracts in systole, also rotates and produces torsion due to the structure of the myocardium. Second, the heart produces a significant electromagnetic field with each contraction due to the coordinated depolarization of myocytes producing a current flow. Unlike the electrocardiogram, the magnetic field is not limited to volume conduction and extends outside the body. The therapeutic potential for interaction of this cardioelectromagnetic field both within and outside the body is largely unexplored. It is our hypothesis that the heart functions as a generator of bioinformation that is central to normative functioning of body. The source of this bioinformation is based on: (1) vortex blood flow in the left ventricle; (2) a cardiac electromagnetic field and both; (3) heart sounds; and (4) pulse pressure which produce frequency and amplitude information. Thus, there is a multidimensional role for the heart in physiology and biopsychosocial dynamics. Recognition of these cardiac properties may result in significant implications for new therapies for cardiovascular disease based on increasing cardiac energy efficiency (coherence) and bioinformation from the cardioelectromagnetic field. Research studies to test this hypothesis are suggested.

The importance of flow history in mixed shear and extensional flows

NASA Astrophysics Data System (ADS)

Wagner, Caroline; McKinley, Gareth

2015-11-01

Many complex fluid flows of experimental and academic interest exhibit mixed kinematics with regions of shear and elongation. Examples include flows through planar hyperbolic contractions in microfluidic devices and through porous media or geometric arrays. Through the introduction of a ``flow-type parameter'' α which varies between 0 in pure shear and 1 in pure elongation, the local velocity fields of all such mixed flows can be concisely characterized. It is tempting to then consider the local stress field and interpret the local state of stress in a complex fluid in terms of shearing or extensional material functions. However, the material response of such fluids exhibit a fading memory of the entire deformation history. We consider a dilute solution of Hookean dumbbells and solve the Oldroyd-B model to obtain analytic expressions for the entire stress field in any arbitrary mixed flow of constant strain rate and flow-type parameter α. We then consider a more complex flow for which the shear rate is constant but the flow-type parameter α varies periodically in time (reminiscent of flow through a periodic array or through repeated contractions and expansions). We show that the flow history and kinematic sequencing (in terms of whether the flow was initialized as shearing or extensional) is extremely important in determining the ensuing stress field and rate of dissipated energy in the flow, and can only be ignored in the limit of infinitely slow flow variations.

Forearm Muscle Oxygenation Decreases During Low Levels of Brief, Isometric Contraction

NASA Technical Reports Server (NTRS)

Murthy Gita; Kahan, N. J.; Hargens, Alan R.; Rempel, D. M.; Hargens, Murthy G. (Technical Monitor)

1997-01-01

Regional muscle pain syndromes can be caused by repeated and sustained exertion of a specific muscle. Such exertion may elevate local tissue fluid pressure, reduce blood flow and tissue oxygenation (TO2), and cause fatigue, pain and functional deficits of the Involved muscle. Low levels (less than 20% maximum voluntary contraction (MVC)) of prolonged static contraction of the upper extremity are common In many occupational settings and May cause fatigue. The purpose of our Investigation was to determine whether TO2 decreases significantly at low levels of static contraction of the extensor carpi radialis brevis (ECRB).

Nanofluid transport in a living soft microtube

NASA Astrophysics Data System (ADS)

Sung, Baeckkyoung; Kim, Se Hoon; Lee, Sungwoo; Lim, Jaekwan; Lee, Jin-Kyu; Soh, Kwang-Sup

2015-09-01

The mechanism of hydrodynamic transport of nanoparticles in living tissues by intrinsic lymphatic pumping remains one of the fundamental questions in the field of nanomedicine. However, despite its importance, direct visualization of the nanofluid transport mechanism has not been achieved. In this article, we report a novel in situ fluorescence bioimaging method for observing real-time microflow patterns of nanofluids confined in a contracting and expanding soft microtube. This method allows for physiological monitoring of spatiotemporally resolved microfluidic behaviour and channel undulation during the peristaltic transport of fluorescent nanoparticle suspensions by lymph vessels embedded in bulky tissues at the location of the hindlimb. The fluorescent nanofluid conferred a high optical contrast for the visualization of the lymphatic microtube, with which the concentration and viscosity of the nanofluid could be determined. The nanofluid and microtube mechanics of the hindlimb lymph vessels exhibited similar behaviours as the previously described base fluid flow of peristaltic mesenteric lymph vessels. Specifically, the microtube contraction and expansion induced increased forward flows, and a reverse flow developed at the maximum contraction, all of which corresponded to Poiseuille flow and implied that higher tube wall shear stress was related to increased axial flow velocity. On the other hand, our study identified a highly heterogeneous flow pattern that could appear during the microtube expansion phase, whose axial velocity profile remarkably deviated from the Hagen-Poiseuille equation. In addition, the peristaltic pumping power was estimated to be on the nanowatt order of magnitude. Finally, we discuss the possible applications of this nanofluidic model system in the context of nanobiotechnology.

The influence of Reynolds numbers on resistance properties of jet pumps

DOE Office of Scientific and Technical Information (OSTI.GOV)

Geng, Q.; Graduate University of Chinese Academy of Sciences, Beijing 100049; Zhou, G.

2014-01-29

Jet pumps are widely used in thermoacoustic Stirling heat engines and pulse tube cryocoolers to eliminate the effect of Gedeon streaming. The resistance properties of jet pumps are principally influenced by their structures and flow regimes which are always characterized by Reynolds numbers. In this paper, the jet pump of which cross section contracts abruptly is selected as our research subject. Based on linear thermoacoustic theory, a CFD model is built and the oscillating flow of the working gas is simulated and analyzed with different Reynolds numbers in the jet pump. According to the calculations, the influence of different structuresmore » and Reynolds numbers on the resistance properties of the jet pump are analyzed and presented. The results show that Reynolds numbers have a great influence on the resistance properties of jet pumps and some empirical formulas which are widely used are unsuitable for oscillating flow with small Reynolds numbers. This paper provides a more comprehensive understanding on resistance properties of jet pumps with oscillating flow and is significant for the design of jet pumps in practical thermoacoustic engines and refrigerators.« less

The influence of Reynolds numbers on resistance properties of jet pumps

NASA Astrophysics Data System (ADS)

Geng, Q.; Zhou, G.; Li, Q.

2014-01-01

Jet pumps are widely used in thermoacoustic Stirling heat engines and pulse tube cryocoolers to eliminate the effect of Gedeon streaming. The resistance properties of jet pumps are principally influenced by their structures and flow regimes which are always characterized by Reynolds numbers. In this paper, the jet pump of which cross section contracts abruptly is selected as our research subject. Based on linear thermoacoustic theory, a CFD model is built and the oscillating flow of the working gas is simulated and analyzed with different Reynolds numbers in the jet pump. According to the calculations, the influence of different structures and Reynolds numbers on the resistance properties of the jet pump are analyzed and presented. The results show that Reynolds numbers have a great influence on the resistance properties of jet pumps and some empirical formulas which are widely used are unsuitable for oscillating flow with small Reynolds numbers. This paper provides a more comprehensive understanding on resistance properties of jet pumps with oscillating flow and is significant for the design of jet pumps in practical thermoacoustic engines and refrigerators.

Hospital contract management: a descriptive profile.

PubMed Central

Alexander, J A; Lewis, B L

1984-01-01

Despite the dramatic growth in hospital contract management in the last decade, research only recently has begun to provide insights into the structure, operation, and effectiveness of these arrangements. Two descriptive questions regarding hospital contract management are addressed in an effort to increase correspondence between theoretical and evaluative research in this area: (1) how do contract-managed hospitals differ from traditionally managed hospitals? and (2) how do contract-managed hospitals differ from each other? Principal discriminating variables in the analyses are hospital size, control, urban-rural location, region, management organization control, and management organization size. Results of the analysis on a sample of 406 contract-managed hospitals and 401 unaffiliated hospitals reveal important differences between contract-managed and traditionally managed hospitals as well as among contract management organizations. These findings are discussed in terms of their implications for future research and performance evaluations on contract management arrangements. PMID:6490376

Inlet Flow Valve Engine Analyses

NASA Technical Reports Server (NTRS)

Champagne, G. A.

2004-01-01

Pratt&Whitney, under Task Order 13 of the NASA Large Engine Technology (LET) Contract, conducted a study to determine the operating characteristics, performance and weights of Inlet Flow Valve (IFV) propulsion concepts for a Mach 2.4 High Speed Civil Transport (HSCT).

Extraction of long-chain fatty acids in isolated rat heart during acute low-flow ischemia.

PubMed

Richter, W S; Fischer, S; Ernst, N; Munz, D L

2001-07-01

Although beta-oxidation of fatty acids is suppressed rapidly during ischemia, the behavior of fatty acid extraction at different flow rates is incompletely understood. This study assessed the relationship between flow and extraction of (123)I-iodophenylpentadecanoic acid (IPPA) in the isolated heart model, especially at low flow. Isolated hearts from male Wistar rats (n = 15) were subjected to retrograde perfusion with constant flow (Krebs Henseleit solution containing 10 mmol/L glucose). A latex balloon in the left ventricle allowed isovolumetric contractions and ventricular pressure measurements. The extraction of (123)I-IPPA was assessed with the indicator dilution technique and (99m)Tc-albumin as the intravascular reference. The flow was either increased from the control flow (8 mL/min) until 300% or reduced until 10%. (123)I-IPPA extraction was measured three times before and 10 min after flow alteration. The tracer uptake was estimated from the product of net extraction and flow. The mean (123)I-IPPA extraction at the control flow (third measurement) was 51.6% +/- 2.8%. Between flow rates of approximately 25% and 300%, (123)I-IPPA extraction increased exponentially at decreasing flow rates. At flow rates < or =25% of the control flow, (123)I-IPPA extraction was exponentially higher than predicted. (123)I-IPPA uptake and flow changed largely in parallel. During low flow, the rate-pressure product showed the expected decline (perfusion-contraction matching). The extraction of (123)I-IPPA is preserved and slightly increased (relative to flow) during acute low-flow ischemia.

A staggered conservative scheme for every Froude number in rapidly varied shallow water flows

NASA Astrophysics Data System (ADS)

Stelling, G. S.; Duinmeijer, S. P. A.

2003-12-01

This paper proposes a numerical technique that in essence is based upon the classical staggered grids and implicit numerical integration schemes, but that can be applied to problems that include rapidly varied flows as well. Rapidly varied flows occur, for instance, in hydraulic jumps and bores. Inundation of dry land implies sudden flow transitions due to obstacles such as road banks. Near such transitions the grid resolution is often low compared to the gradients of the bathymetry. In combination with the local invalidity of the hydrostatic pressure assumption, conservation properties become crucial. The scheme described here, combines the efficiency of staggered grids with conservation properties so as to ensure accurate results for rapidly varied flows, as well as in expansions as in contractions. In flow expansions, a numerical approximation is applied that is consistent with the momentum principle. In flow contractions, a numerical approximation is applied that is consistent with the Bernoulli equation. Both approximations are consistent with the shallow water equations, so under sufficiently smooth conditions they converge to the same solution. The resulting method is very efficient for the simulation of large-scale inundations.

21 CFR 312.52 - Transfer of obligations to a contract research organization.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 5 2011-04-01 2011-04-01 false Transfer of obligations to a contract research... and Investigators § 312.52 Transfer of obligations to a contract research organization. (a) A sponsor... research organization. Any such transfer shall be described in writing. If not all obligations are...

48 CFR 35.014 - Government property and title.

Code of Federal Regulations, 2011 CFR

2011-10-01

... basic or applied scientific research, apply to contracts with nonprofit institutions of higher education and nonprofit organizations whose primary purpose is the conduct of scientific research: (1) If the... SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.014 Government property and...

48 CFR 2415.605-70 - Unsolicited research proposals.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Unsolicited research... URBAN DEVELOPMENT CONTRACTING METHODS AND CONTRACTING TYPES CONTRACTING BY NEGOTIATION Source Selection 2415.605-70 Unsolicited research proposals. FAR subpart 15.6 outlines the policies and procedures...

48 CFR 1815.403-170 - Waivers of cost or pricing data.

Code of Federal Regulations, 2010 CFR

2010-10-01

... data when contracting for Small Business Innovation Research (SBIR) program Phase II contracts. However... SPACE ADMINISTRATION CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Contract Pricing...

Recovery Migration to the City of New Orleans after Hurricane Katrina: A Migration Systems Approach.

PubMed

Fussell, Elizabeth; Curtis, Katherine J; Dewaard, Jack

2014-03-01

Hurricane Katrina's effect on the population of the City of New Orleans provides a model of how severe weather events, which are likely to increase in frequency and strength as the climate warms, might affect other large coastal cities. Our research focuses on changes in the migration system - defined as the system of ties between Orleans Parish and all other U.S. counties - between the pre-disaster (1999-2004) and recovery (2007-2009) periods. Using Internal Revenue Service county-to-county migration flow data, we find that in the recovery period Orleans Parish increased the number of migration ties with and received larger migration flows from nearby counties in the Gulf of Mexico coastal region, thereby spatially concentrating and intensifying the in-migration dimension of this predominantly urban system, while the out-migration dimension contracted and had smaller flows. We interpret these changes as the migration system relying on its strongest ties to nearby and less damaged counties to generate recovery in-migration.

Higher Education in Non-Standard Wage Contracts

ERIC Educational Resources Information Center

Rosti, Luisa; Chelli, Francesco

2012-01-01

Purpose: The purpose of this paper is to verify whether higher education increases the likelihood of young Italian workers moving from non-standard to standard wage contracts. Design/methodology/approach: The authors exploit a data set on labour market flows, produced by the Italian National Statistical Office, by interviewing about 85,000…

Contraction-Only Exercise Machine

NASA Technical Reports Server (NTRS)

Doerr, Donald F.; Maples, Arthur B.; Campbell, Craig M.

1992-01-01

Standard knee-extension machine modified so subject experiences force only when lifting leg against stack of weights. Exerts little force on leg while being lowered. Hydraulic cylinder and reservoir mounted on frame of exercise machine. Fluid flows freely from cylinder to reservoir during contraction (lifting) but in constricted fashion from reservoir to cylinder during extension (lowering).

78 FR 46365 - Quarterly Status Report of Water Service, Repayment, and Other Water-Related Contract Actions

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-31

... Stream Commission O&M Operation and Maintenance P-SMBP Pick-Sloan Missouri Basin Program PPR Present... stored water from Applegate Reservoir (a USACE project) for irrigation use in exchange for the transfer... of Oregon for instream flow use. Completed contract action: 11. Prineville Reservoir Water Users...

48 CFR 970.35 - Research and development contracting.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Research and development contracting. 970.35 Section 970.35 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Major System Acquisition 970.35 Research and...

48 CFR 970.35 - Research and development contracting.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Research and development contracting. 970.35 Section 970.35 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Major System Acquisition 970.35 Research and...

48 CFR 970.35 - Research and development contracting.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Research and development contracting. 970.35 Section 970.35 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Major System Acquisition 970.35 Research and...

48 CFR 970.35 - Research and development contracting.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Research and development contracting. 970.35 Section 970.35 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Major System Acquisition 970.35 Research and...

Polygon patterns on Europa

NASA Technical Reports Server (NTRS)

Smalley, I. J.

1981-01-01

The formation of polygon patterns in the development of crack networks in cooling basalt flows and similar contracting systems, and under natural conditions in an essentially unbounded basalt flow, are analyzed, and the characteristics of hexagonal and pentagonal patterns in isotropic stress fields are discussed.

Scour in supercritical flow

DOT National Transportation Integrated Search

1988-10-01

Scour in supercritical flow is one extreme aspect of the effects of velocity on scour. Analysis of the case of scour in a long contraction shows that if all other independent variables are kept constant (1) some finite velocity is necessary to have a...

MUSCLEMOTION: A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo.

PubMed

Sala, Luca; van Meer, Berend J; Tertoolen, Leon G J; Bakkers, Jeroen; Bellin, Milena; Davis, Richard P; Denning, Chris; Dieben, Michel A E; Eschenhagen, Thomas; Giacomelli, Elisa; Grandela, Catarina; Hansen, Arne; Holman, Eduard R; Jongbloed, Monique R M; Kamel, Sarah M; Koopman, Charlotte D; Lachaud, Quentin; Mannhardt, Ingra; Mol, Mervyn P H; Mosqueira, Diogo; Orlova, Valeria V; Passier, Robert; Ribeiro, Marcelo C; Saleem, Umber; Smith, Godfrey L; Burton, Francis L; Mummery, Christine L

2018-02-02

There are several methods to measure cardiomyocyte and muscle contraction, but these require customized hardware, expensive apparatus, and advanced informatics or can only be used in single experimental models. Consequently, data and techniques have been difficult to reproduce across models and laboratories, analysis is time consuming, and only specialist researchers can quantify data. Here, we describe and validate an automated, open-source software tool (MUSCLEMOTION) adaptable for use with standard laboratory and clinical imaging equipment that enables quantitative analysis of normal cardiac contraction, disease phenotypes, and pharmacological responses. MUSCLEMOTION allowed rapid and easy measurement of movement from high-speed movies in (1) 1-dimensional in vitro models, such as isolated adult and human pluripotent stem cell-derived cardiomyocytes; (2) 2-dimensional in vitro models, such as beating cardiomyocyte monolayers or small clusters of human pluripotent stem cell-derived cardiomyocytes; (3) 3-dimensional multicellular in vitro or in vivo contractile tissues, such as cardiac "organoids," engineered heart tissues, and zebrafish and human hearts. MUSCLEMOTION was effective under different recording conditions (bright-field microscopy with simultaneous patch-clamp recording, phase contrast microscopy, and traction force microscopy). Outcomes were virtually identical to the current gold standards for contraction measurement, such as optical flow, post deflection, edge-detection systems, or manual analyses. Finally, we used the algorithm to quantify contraction in in vitro and in vivo arrhythmia models and to measure pharmacological responses. Using a single open-source method for processing video recordings, we obtained reliable pharmacological data and measures of cardiac disease phenotype in experimental cell, animal, and human models. © 2017 The Authors.

Simulation of late inspiratory rise in airway pressure during pressure support ventilation.

PubMed

Yu, Chun-Hsiang; Su, Po-Lan; Lin, Wei-Chieh; Lin, Sheng-Hsiang; Chen, Chang-Wen

2015-02-01

Late inspiratory rise in airway pressure (LIRAP, Paw/ΔT) caused by inspiratory muscle relaxation or expiratory muscle contraction is frequently seen during pressure support ventilation (PSV), although the modulating factors are unknown. We investigated the effects of respiratory mechanics (normal, obstructive, restrictive, or mixed), inspiratory effort (-2, -8, or -15 cm H2O), flow cycle criteria (5-40% peak inspiratory flow), and duration of inspiratory muscle relaxation (0.18-0.3 s) on LIRAP during PSV using a lung simulator and 4 types of ventilators. LIRAP occurred with all lung models when inspiratory effort was medium to high and duration of inspiratory muscle relaxation was short. The normal lung model was associated with the fastest LIRAP, whereas the obstructive lung model was associated with the slowest. Unless lung mechanics were normal or mixed, LIRAP was unlikely to occur when inspiratory effort was low. Different ventilators were also associated with differences in LIRAP speed. Except for within the restrictive lung model, changes in flow cycle level did not abolish LIRAP if inspiratory effort was medium to high. Increased duration of inspiratory relaxation also led to the elimination of LIRAP. Simulation of expiratory muscle contraction revealed that LIRAP occurred only when expiratory muscle contraction occurred sometime after the beginning of inspiration. Our simulation study reveals that both respiratory resistance and compliance may affect LIRAP. Except for under restrictive lung conditions, LIRAP is unlikely to be abolished by simply lowering flow cycle criteria when inspiratory effort is strong and relaxation time is rapid. LIRAP may be caused by expiratory muscle contraction when it occurs during inspiration. Copyright © 2015 by Daedalus Enterprises.

Level II scour analysis for Bridge 21 (MIDBTH00230021) on Town Highway 23, crossing the Middlebury River, Middlebury, Vermont

USGS Publications Warehouse

Boehmler, Erick M.; Degnan, James R.

1997-01-01

year discharges. In addition, the incipient roadway-overtopping discharge is determined and analyzed as another potential worst-case scour scenario. Total scour at a highway crossing is comprised of three components: 1) long-term streambed degradation; 2) contraction scour (due to accelerated flow caused by a reduction in flow area at a bridge) and; 3) local scour (caused by accelerated flow around piers and abutments). Total scour is the sum of the three components. Equations are available to compute depths for contraction and local scour and a summary of the results of these computations follows. Contraction scour for all modelled flows ranged from 1.2 to 1.8 feet. The worst-case contraction scour occurred at the incipient overtopping discharge, which is less than the 500-year discharge. Abutment scour ranged from 17.7 to 23.7 feet. The worst-case abutment scour occurred at the 500-year discharge. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A cross-section of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1995, p. 47). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

Level II scour analysis for Bridge 4 (MNTGTH00020004) on Town Highway 2, crossing Wade Brook, Montgomery, Vermont

USGS Publications Warehouse

Boehmler, Erick M.

1996-01-01

Total scour at a highway crossing is comprised of three components: 1) long-term streambed degradation; 2) contraction scour (due to accelerated flow caused by a reduction in flow area at a bridge) and; 3) local scour (caused by accelerated flow around piers and abutments). Total scour is the sum of the three components. Equations are available to compute depths for contraction and local scour and a summary of the results of these computations follows. Contraction scour for all modelled flows was 0.1 ft. The worst-case contraction scour occurred at the 100-year and 500-year discharges. Abutment scour ranged from 3.9 to 5.2 ft. The worst-case abutment scour also occurred at the 500-year discharge. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A cross-section of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1995, p. 47). Many factors, including historical performance during flood events, the geomorphic assessment, scour protection measures, and the results of the hydraulic analyses, must be considered to properly assess the validity of abutment scour results. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein, based on the consideration of additional contributing factors and experienced engineering judgement.

Level II scour analysis for Bridge 46 (CHELTH00680046) on Town Highway 68, crossing the First Branch of the White River, Chelsea, Vermont

USGS Publications Warehouse

Ivanoff, Michael A.; Song, Donald L.

1996-01-01

Total scour at a highway crossing is comprised of three components: 1) long-term streambed degradation; 2) contraction scour (due to accelerated flow caused by a reduction in flow area at a bridge) and; 3) local scour (caused by accelerated flow around piers and abutments). Total scour is the sum of the three components. Equations are available to compute depths for contraction and local scour and a summary of the results of these computations follows. Contraction scour for all modelled flows ranged from 0.9 to 2.6 ft. The worst-case contraction scour occurred at the 500-year discharge. Abutment scour ranged from 14.3 to 24.0 ft. The worst-case abutment scour occurred at the 500-year discharge. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A cross-section of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. The left abutment sits atop a bedrock outcrop. The results of the calculated scour depths will be limited by the bedrock. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1995, p. 47). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

Novel Bio-inspired Aquatic Flow Sensors

DTIC Science & Technology

2012-06-18

Novel Bio-inspired Aquatic Flow Sensors Preston Albert Pinto Thesis submitted to the Faculty of the Virginia Polytechnic Institute and...Leo, Chair Stephen A. Sarles Michael K. Philen Pavlos Vlachos June 18th, 2012 Blacksburg, Virginia Keywords: artificial hair cell, flow ...Aquatic Flow Sensors 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT

10 CFR 733.8 - Contracting officer procedures.

Code of Federal Regulations, 2012 CFR

2012-01-01

... DEPARTMENT OF ENERGY ALLEGATIONS OF RESEARCH MISCONDUCT § 733.8 Contracting officer procedures. Upon receipt of an allegation of research misconduct by referral under § 733.7, the contracting officer should, by... assistance recipient to act on the allegation consistent with the Research Misconduct requirements in the...

10 CFR 733.8 - Contracting officer procedures.

Code of Federal Regulations, 2010 CFR

2010-01-01

... DEPARTMENT OF ENERGY ALLEGATIONS OF RESEARCH MISCONDUCT § 733.8 Contracting officer procedures. Upon receipt of an allegation of research misconduct by referral under § 733.7, the contracting officer should, by... assistance recipient to act on the allegation consistent with the Research Misconduct requirements in the...

10 CFR 733.8 - Contracting officer procedures.

Code of Federal Regulations, 2014 CFR

2014-01-01

... DEPARTMENT OF ENERGY ALLEGATIONS OF RESEARCH MISCONDUCT § 733.8 Contracting officer procedures. Upon receipt of an allegation of research misconduct by referral under § 733.7, the contracting officer should, by... assistance recipient to act on the allegation consistent with the Research Misconduct requirements in the...

10 CFR 733.8 - Contracting officer procedures.

Code of Federal Regulations, 2013 CFR

2013-01-01

... DEPARTMENT OF ENERGY ALLEGATIONS OF RESEARCH MISCONDUCT § 733.8 Contracting officer procedures. Upon receipt of an allegation of research misconduct by referral under § 733.7, the contracting officer should, by... assistance recipient to act on the allegation consistent with the Research Misconduct requirements in the...

10 CFR 733.8 - Contracting officer procedures.

Code of Federal Regulations, 2011 CFR

2011-01-01

... DEPARTMENT OF ENERGY ALLEGATIONS OF RESEARCH MISCONDUCT § 733.8 Contracting officer procedures. Upon receipt of an allegation of research misconduct by referral under § 733.7, the contracting officer should, by... assistance recipient to act on the allegation consistent with the Research Misconduct requirements in the...

48 CFR 27.406-2 - Additional data requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... solicitations and contracts involving experimental, developmental, research or demonstration work (other than basic or applied research to be performed under a contract solely by a university or college when the..., research, or demonstration contracts, it may not be feasible to ascertain all the data requirements at...

Consequences of intravascular lymphatic valve properties: a study of contraction timing in a multi-lymphangion model

PubMed Central

Macaskill, Charlie; Davis, Michael J.; Moore, James E.

2016-01-01

The observed properties of valves in collecting lymphatic vessels include transmural pressure-dependent bias to the open state and hysteresis. The bias may reduce resistance to flow when the vessel is functioning as a conduit. However, lymphatic pumping implies a streamwise increase in mean pressure across each valve, suggesting that the bias is then potentially unhelpful. Lymph pumping by a model of several collecting lymphatic vessel segments (lymphangions) in series, which incorporated these properties, was investigated under conditions of adverse pressure difference while varying the refractory period between active muscular contractions and the inter-lymphangion contraction delay. It was found that many combinations of the timing parameters and the adverse pressure difference led to one or more intermediate valves remaining open instead of switching between open and closed states during repetitive contraction cycles. Cyclic valve switching was reliably indicated if the mean pressure in a lymphangion over a cycle was higher than that in the lymphangion upstream, but either lack of or very brief valve closure could cause mean pressure to be lower downstream. Widely separated combinations of refractory period and delay time were found to produce the greatest flow-rate for a given pressure difference. The efficiency of pumping was always maximized by a long refractory period and lymphangion contraction starting when the contraction of the lymphangion immediately upstream was peaking. By means of an ex vivo experiment, it was verified that intermediate valves in a chain of pumping lymphangions can remain open, while the lymphangions on either side of the open valve continue to execute contractions. PMID:26747501

Matching of postcontraction perfusion to oxygen consumption across submaximal contraction intensities in exercising humans.

PubMed

Buck, Amanda K W; Elder, Christopher P; Donahue, Manus J; Damon, Bruce M

2015-08-01

Studying the magnitude and kinetics of blood flow, oxygen extraction, and oxygen consumption at exercise onset and during the recovery from exercise can lead to insights into both the normal control of metabolism and blood flow and the disturbances to these processes in metabolic and cardiovascular diseases. The purpose of this study was to examine the on- and off-kinetics for oxygen delivery, extraction, and consumption as functions of submaximal contraction intensity. Eight healthy subjects performed four 1-min isometric dorsiflexion contractions, with two at 20% MVC and two at 40% MVC. During one contraction at each intensity, relative perfusion changes were measured by using arterial spin labeling, and the deoxyhemoglobin percentage (%HHb) was estimated using the spin- and gradient-echo sequence and a previously published empirical calibration. For the whole group, the mean perfusion did not increase during contraction. The %HHb increased from ∼28 to 38% during contractions of each intensity, with kinetics well described by an exponential function and mean response times (MRTs) of 22.7 and 21.6 s for 20 and 40% MVC, respectively. Following contraction, perfusion increased ∼2.5-fold. The %HHb, oxygen consumption, and perfusion returned to precontraction levels with MRTs of 27.5, 46.4, and 50.0 s, respectively (20% MVC), and 29.2, 75.3, and 86.0 s, respectively (40% MVC). These data demonstrate in human subjects the varied recovery rates of perfusion and oxygen consumption, along with the similar rates of %HHb recovery, across these exercise intensities. Copyright © 2015 the American Physiological Society.

Acetyl group availability influences phosphocreatine degradation even during intense muscle contraction

PubMed Central

Timmons, James A; Constantin-Teodosiu, Dumitru; Poucher, Simon M; Greenhaff, Paul L

2004-01-01

We previously established that activation of the pyruvate dehydrogenase complex (PDC) using dichloroacetate (DCA) reduced the reliance on substrate-level phosphorylation (SLP) at the onset of exercise, with normal and reduced blood flow. PDC activation also reduced fatigue development during contraction with reduced blood flow. Since these observations, several studies have re-evaluated our observations. One study demonstrated a performance benefit without a reduction in SLP, raising a question mark over PDC's role in the regulation of ATP regeneration and our interpretation of fatigue mechanisms. Using a model of muscle contraction similar to the conflicting study (i.e. tetanic rather than twitch stimulation), we re-examined this question. Using canine skeletal muscle, one group was infused with saline while the other was pretreated with 300 mg (kg body mass)−1 DCA. Muscle biopsies were taken at rest, peak tension (1 min) and after 6 min of tetanic electrical stimulation (75 ms on−925 ms off per second) and blood flow was limited to 25% of normal values observed during contraction. DCA reduced phosphocreatine (PCr) degradation by 40% during the first minute of contraction, but did not prevent the almost complete depletion of PCr stores at 6 min, while muscle fatigue did not differ between the two groups. During intermittent tetanic stimulation PCr degradation was 75% greater than with our previous 3 Hz twitch contraction protocol, despite a similar rate of oxygen consumption at 6 min. Thus, in the present study enhanced acetyl group availability altered the time course of PCr utilization but did not prevent the decline towards depletion. Consistent with our earlier conclusions, DCA pretreatment reduces muscle fatigue only when SLP is attenuated. The present study and our met-analysis indicates that enhanced acetyl group availability results in a readily measurable reduction in SLP when the initial rate of PCr utilization is ∼1 mmol (kg dry mass)−1 s−1 or less (depending on intrinsic mitochondrial capacity). When measured early during an uninterrupted period of muscle contraction, acetyl group availability is likely to influence SLP under any condition where mitochondria are responsible for a significant proportion of ATP regeneration. PMID:15498812

The NO donor sodium nitroprusside: evaluation of skeletal muscle vascular and metabolic dysfunction

PubMed Central

Hirai, Daniel M.; Copp, Steven W.; Ferguson, Scott K.; Holdsworth, Clark T.; Musch, Timothy I.; Poole, David C.

2012-01-01

The nitric oxide (NO) donor sodium nitroprusside (SNP) may promote cyanide-induced toxicity and systemic and/or local responses approaching maximal vasodilation. The hypotheses were tested that SNP superfusion of the rat spinotrapezius muscle exerts 1) residual impairments in resting and contracting blood flow, oxygen utilization (V̇O2) and microvascular O2 pressure (PO2mv); and 2) marked hypotension and elevation in resting PO2mv. Two superfusion protocols were performed: 1) Krebs-Henseleit (control 1), SNP (300 µM; a dose used commonly in superfusion studies) and Krebs-Henseleit (control 2), in this order; 2) 300 and 1200 µM SNP in random order. Spinotrapezius muscle blood flow (radiolabeled microspheres), V̇O2 (Fick calculation) and PO2mv (phosphorescence quenching) were determined at rest and during electrically-induced (1 Hz) contractions. There were no differences in spinotrapezius blood flow, V̇O2 or PO2mv at rest and during contractions pre- and post-SNP condition (control 1 and control 2; p>0.05 for all). With regard to dosing, SNP produced a graded elevation in resting PO2mv (p<0.05) with a reduction in mean arterial pressure only at the higher concentration (p<0.05). Contrary to our hypothesis, skeletal muscle superfusion with the NO donor SNP (300 µM) improved microvascular oxygenation during the transition from rest to contractions (PO2mv kinetics) without precipitating residual impairment of muscle hemodynamic or metabolic control or compromising systemic hemodynamics. These data suggest that SNP superfusion (300 µM) constitutes a valid and important tool for assessing the functional roles of NO in resting and contracting skeletal muscle function without incurring residual alterations consistent with cyanide accumulation and poisoning. PMID:23174313

Genetic Variations in SLCO Transporter Genes Contributing to Racial Disparity in Aggressiveness of Prostate Cancer

DTIC Science & Technology

2016-10-01

Contract Specialist U.S. Army Medical Research Acquisition Activity, MCMR- AAA -E, 820 Chandler Street, Fort Detrick, MD 21702-5014 Phone: (301) 619-4018...Funding Agency’s Procuring Contracting/Grants Officer: Ayi Ayayi, Contract Specialist U.S. Army Medical Research Acquisition Activity, MCMR- AAA -E, 820...Ayayi, Contract Specialist, U.S. Army Medical Research Acquisition Activity, MCMR- AAA -E, 820 Chandler Street, Fort Detrick, MD 21702-5014 Phone

48 CFR 235.072 - Additional contract clauses.

Code of Federal Regulations, 2014 CFR

2014-10-01

... contracts for research and development. (d) Use the clause at 252.235-7011, Final Scientific or Technical Report, in solicitations and contracts for research and development. (e) Use the clause at 252.235-7004...

48 CFR 237.102-78 - Market research report guide for improving the tradecraft in services acquisition.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING SERVICE CONTRACTING Service Contracts-General 237.102-78 Market research report... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Market research report...

48 CFR 237.102-78 - Market research report guide for improving the tradecraft in services acquisition.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING SERVICE CONTRACTING Service Contracts-General 237.102-78 Market research report... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Market research report...

48 CFR 237.102-78 - Market research report guide for improving the tradecraft in services acquisition.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING SERVICE CONTRACTING Service Contracts-General 237.102-78 Market research report... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Market research report...

Estimation of potential scour at bridges on local government roads in South Dakota, 2009-12

USGS Publications Warehouse

Thompson, Ryan F.; Wattier, Chelsea M.; Liggett, Richard R.; Truax, Ryan A.

2014-01-01

In 2009, the U.S. Geological Survey and South Dakota Department of Transportation (SDDOT) began a study to estimate potential scour at selected bridges on local government (county, township, and municipal) roads in South Dakota. A rapid scour-estimation method (level-1.5) and a more detailed method (level-2) were used to develop estimates of contraction, abutment, and pier scour. Data from 41 level-2 analyses completed for this study were combined with data from level-2 analyses completed in previous studies to develop new South Dakota-specific regression equations: four regional equations for main-channel velocity at the bridge contraction to account for the widely varying stream conditions within South Dakota, and one equation for head change. Velocity data from streamgages also were used in the regression for average velocity through the bridge contraction. Using these new regression equations, scour analyses were completed using the level-1.5 method on 361 bridges on local government roads. Typically, level-1.5 analyses are completed at flows estimated to have annual exceedance probabilities of 1 percent (100-year flood) and 0.2 percent (500-year flood); however, at some sites the bridge would not pass these flows. A level-1.5 analysis was then completed at the flow expected to produce the maximum scour. Data presented for level-1.5 scour analyses at the 361 bridges include contraction, abutment, and pier scour. Estimates of potential contraction scour ranged from 0 to 32.5 feet for the various flows evaluated. Estimated potential abutment scour ranged from 0 to 40.9 feet for left abutments, and from 0 to 37.7 feet for right abutments. Pier scour values ranged from 2.7 to 31.6 feet. The scour depth estimates provided in this report can be used by the SDDOT to compare with foundation depths at each bridge to determine if abutments or piers are at risk of being undermined by scour at the flows evaluated. Replicate analyses were completed at 24 of the 361 bridges to provide quality-assurance/quality-control measures for the level-1.5 scour estimates. An attempt was made to use the same flows among replicate analyses. Scour estimates do not necessarily have to be in numerical agreement to give the same results. For example, if contraction scour replicate analyses are 18.8 and 30.8 feet, both scour depths can indicate susceptibility to scour for which countermeasures may be needed, even though one number is much greater than the other number. Contraction scour has perhaps the greatest potential for being estimated differently in replicate visits. For contraction scour estimates at the various flows analyzed, differences between results ranged from -7.8 to 5.5 feet, with a median difference of 0.4 foot and an average difference of 0.2 foot. Abutment scour appeared to be nearly as reproducible as contraction scour. For abutment scour estimates at the varying flows analyzed, differences between results ranged from -17.4 to 11 feet, with a median difference of 1.4 feet and an average difference of 1.7 feet. Estimates of pier scour tended to be the most consistently reproduced in replicate visits, with differences between results ranging from -0.3 to 0.5 foot, with a median difference of 0.0 foot and an average difference of 0.0 foot. The U.S. Army Corps of Engineers Hydraulics Engineering Center River Analysis Systems (HEC-RAS) software package was used to model stream hydraulics at the 41 sites with level-2 analyses. Level-1.5 analyses also were completed at these sites, and the performance of the level-1.5 method was assessed by comparing results to those from the more rigorous level-2 method. The envelope curve approach used in the level-1.5 method is designed to overestimate scour relative to the estimate from the level-2 scour analysis. In cases where the level-1.5 method estimated less scour than the level-2 method, the amount of underestimation generally was less than 3 feet. The level-1.5 method generally overestimated contraction, abutment, and pier scour relative to the level-2 method, as intended. Although the level-1.5 method is designed to overestimate scour relative to more involved analysis methods, many assumptions, uncertainties, and estimations are involved. If the envelope curves are adjusted such that the level-1.5 method never underestimates scour relative to the level-2 method, an accompanying result may be excessive overestimation.

Guidelines for cost control and analysis of cost-type research and development contracts

NASA Technical Reports Server (NTRS)

Sibbers, C. W.

1981-01-01

The cost information which should be obtained from a contractor(s) on a major, cost type research and development contract(s), and the analyses and effective use of these data are discussed. Specific type(s) of information which should be required, methods for analyzing such information, and methods for effectively using the results of such analyses to enhance NASA contract and project management are included. The material presented is based primarily on the principal methods which have been effectively used in the management of major cost type research and development contracts.

48 CFR 45.107 - Contract clauses.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Alternate II when a contract for the conduct of basic or applied research at nonprofit institutions of... research (see 35.014) is contemplated. (b) The contracting officer shall also insert the clause at 52.245-2...

Discrete simulations of spatio-temporal dynamics of small water bodies under varied stream flow discharges

NASA Astrophysics Data System (ADS)

Daya Sagar, B. S.

2005-01-01

Spatio-temporal patterns of small water bodies (SWBs) under the influence of temporally varied stream flow discharge are simulated in discrete space by employing geomorphologically realistic expansion and contraction transformations. Cascades of expansion-contraction are systematically performed by synchronizing them with stream flow discharge simulated via the logistic map. Templates with definite characteristic information are defined from stream flow discharge pattern as the basis to model the spatio-temporal organization of randomly situated surface water bodies of various sizes and shapes. These spatio-temporal patterns under varied parameters (λs) controlling stream flow discharge patterns are characterized by estimating their fractal dimensions. At various λs, nonlinear control parameters, we show the union of boundaries of water bodies that traverse the water body and non-water body spaces as geomorphic attractors. The computed fractal dimensions of these attractors are 1.58, 1.53, 1.78, 1.76, 1.84, and 1.90, respectively, at λs of 1, 2, 3, 3.46, 3.57, and 3.99. These values are in line with general visual observations.

From cells to tissue: A continuum model of epithelial mechanics

NASA Astrophysics Data System (ADS)

Ishihara, Shuji; Marcq, Philippe; Sugimura, Kaoru

2017-08-01

A two-dimensional continuum model of epithelial tissue mechanics was formulated using cellular-level mechanical ingredients and cell morphogenetic processes, including cellular shape changes and cellular rearrangements. This model incorporates stress and deformation tensors, which can be compared with experimental data. Focusing on the interplay between cell shape changes and cell rearrangements, we elucidated dynamical behavior underlying passive relaxation, active contraction-elongation, and tissue shear flow, including a mechanism for contraction-elongation, whereby tissue flows perpendicularly to the axis of cell elongation. This study provides an integrated scheme for the understanding of the orchestration of morphogenetic processes in individual cells to achieve epithelial tissue morphogenesis.

Engineering the Flow of Liquid Two-Phase Systems by Passive Noise Control

NASA Astrophysics Data System (ADS)

Zhang, Zeyi; Kong, Tiantian; Zhou, Chunmei; Wang, Liqiu

2018-02-01

We investigate a passive noise-control approach to engineering the two-phase flow in a microfluidic coflow system. The presence or absence of the jet breakup is studied for two immiscible oil phases, in a straight microchannel (referred to as the J device in the main text), an expansion microchannel (the W device) and a microchannel with the expansion-contraction geometry (the S device), respectively. We show that the jet breaks into droplets, in the jetting regime and the dripping regime (also referred to as the widening-jetting regime) for the straight channel and expansion channel, respectively, while a stable long jet does not break for the expansion-contraction geometry. As the inner phase passes the expansion-contraction functional unit, the random noise on the interface is significantly reduced and the hydrodynamic instability is suppressed, for a range of experimental parameters including flow rates, device geometry, liquid viscosity, and interfacial tension. We further present scale-up devices with multiple noise-control units and achieve decimeter-long yet stable jets. Our simple, effective, and robust noise-control approach can benefit microfluidic applications such as microfiber fabrication, interface chemical reaction, and on-chip distance transportation.

Surfing and Swimming of Ejaculated Sperm in the Mouse Oviduct.

PubMed

Ishikawa, Yu; Usui, Tomoyuki; Yamashita, Misuzu; Kanemori, Yoshinori; Baba, Tadashi

2016-04-01

To accomplish fertilization in the oviductal ampulla, ejaculated sperm are required to migrate through the female reproductive tract. However, this fundamental process largely remains unknown. In this study, we focused on the role of oviductal smooth muscle (myosalpinx) contractions in the sperm migration. Administration of prifinium bromide, padrin, to mice effectively suppressed myosalpinx contractions, resulting in a decreased rate of fertilization in a dose-dependent manner, and an abrogation of high-speed back-and-forth/shuttling flows of oviductal fluids around the isthmus. Regardless of padrin administration, no shuttling flows were found near the ampulla. In the isthmus, sperm formed a tight assemblage that was synchronized with the shuttling flows. The sperm assemblage was gradually loosened and then completely abolished near the ampulla. No sperm assemblage was formed in the isthmus when padrin was administrated. These results suggest that myosalpinx contractions play important roles in the formation of sperm assemblage in the isthmus, and in the transport of the assemblage to the middle region of the oviduct. It is also suggested that the motility of sperm is essential for the migration of sperm from the middle oviductal region to the ampulla. © 2016 by the Society for the Study of Reproduction, Inc.

National Air Space (NAS) Data Exchange Environment Through 2060

NASA Technical Reports Server (NTRS)

Roy, Aloke

2015-01-01

NASA's NextGen Concepts and Technology Development (CTD) Project focuses on capabilities to improve safety, capacity and efficiency of the National Air Space (NAS). In order to achieve those objectives, NASA sought industry-Government partnerships to research and identify solutions for traffic flow management, dynamic airspace configuration, separation assurance, super density operations, airport surface operations and similar forward-looking air-traffic modernization (ATM) concepts. Data exchanges over NAS being the key enabler for most of these ATM concepts, the Sub-Topic area 3 of the CTD project sought to identify technology candidates that can satisfy air-to-air and air/ground communications needs of the NAS in the year 2060 timeframe. Honeywell, under a two-year contract with NASA, is working on this communications technology research initiative. This report summarizes Honeywell's research conducted during the second year of the study task.

Pharmacological characteristics of endothelin receptors on sheep rectal blood vessels.

PubMed

Lohsiriwat, Varut; Scholefield, John H; Dashwood, Michael R; Wilson, Vincent G

2011-06-01

Haemorrhoids is associated with high blood flow of the anorectal region. The question of whether pharmacological manipulation of vascular supply can relieve the symptoms of haemorrhoids has been raised. In order to undertake this type of clinical investigation, it is first essential to gain a better understanding of the properties of vascular receptors that may regulate blood flow into anal cushions and haemorrhoids. Due to the limited availability of human anorectal specimens and the good reliability of sheep tissue as an experimental model of human anorectal diseases, we studied the properties of endothelin receptors in sheep rectal artery (SRA) and vein (SRV), the vessels contributing to the blood flow of haemorrhoidal plexus, using isometric tension recordings. We found that endothelin-1 and sarafotoxin 6a were very potent constrictor agents in both SRA and SRV. The selective ET(A) receptor antagonist PD156707 (100 nM) produced a parallel rightward displacement of ET-1-induced contractions in both vessels and abolished sarafotoxin 6a-induced contractions in the SRA. PD156707 (3 μM) practically abolished contractions to ET-1 in the SRA, suggesting that the response is entirely mediated by ET(A) receptors. While, the selective ET(B) receptor antagonist BQ788 (100 nM) caused no significant change in ET-1-induced contractions in both vessels, a minor role for ET(B) receptor subtype to responses to sarafotoxin 6a in the artery was suggested. Copyright © 2011 Elsevier Ltd. All rights reserved.

Circulation of fluids in the gastrovascular system of a stoloniferan octocoral.

PubMed

Parrin, Austin P; Netherton, Sarah E; Bross, Lori S; McFadden, Catherine S; Blackstone, Neil W

2010-10-01

Cilia-based transport systems characterize sponges and placozoans. Cilia are employed in cnidarian gastrovascular systems as well, but typically function in concert with muscular contractions. Previous reports suggest that anthozoans may be an exception to this pattern, utilizing only cilia in their gastrovascular systems. With an inverted microscope and digital image analysis, we used stoloniferan octocoral colonies growing on microscope cover glass to quantitatively describe the movement of fluids in this system for the first time. Flow in stolons (diameter ≈300 μm) is simultaneously bidirectional, with average velocities of 100-200 μm/s in each direction. Velocities are maximal immediately adjacent to the stolon wall and decrease to a minimum in the center of the stolon. Flow velocity is unaffected by stolonal contractions, suggesting that muscular peristalsis is not a factor in propelling the flow. Stolon intersections (diameter ≈500 μm) occur below polyps and serve as traffic roundabouts with unidirectional, circular flow. Such cilia-driven transport may be the plesiomorphic state for the gastrovascular system of cnidarians.

Analytical models for use in fan inflow control structure design. Inflow distortion and acoustic transmission models

NASA Technical Reports Server (NTRS)

Gedge, M. R.

1979-01-01

Analytical models were developed to study the effect of flow contraction and screening on inflow distortions to identify qualitative design criteria. Results of the study are that: (1) static testing distortions are due to atmospheric turbulence, nacelle boundary layer, exhaust flow reingestion, flow over stand, ground plane, and engine casing; (2) flow contraction suppresses, initially, turbulent axial velocity distortions and magnifies turbulent transverse velocity distortions; (3) perforated plate and gauze screens suppress axial components of velocity distortions to a degree determined by the screen pressure loss coefficient; (4) honeycomb screen suppress transverse components of velocity distortions to a degree determined by the length to diameter ratio of the honeycomb; (5) acoustic transmission loss of perforated plate is controlled by the reactance of its acoustic impedance; (6) acoustic transmission loss of honeycomb screens is negligible; and (7) a model for the direction change due to a corner between honeycomb panels compares favorably with measured data.

77 FR 47797 - Federal Acquisition Regulation; Small Business Set Asides for Research and Development Contracts

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-10

... Acquisition Regulation; Small Business Set Asides for Research and Development Contracts AGENCY: Department of... Acquisition Regulation (FAR) to clarify that contracting officers shall set aside acquisitions for research..., and NASA are proposing to amend the Federal Acquisition Regulation (FAR) to revise paragraph (b)(2) of...

48 CFR 250.104-3-70 - Indemnification under contracts involving both research and development and other work.

Code of Federal Regulations, 2010 CFR

2010-10-01

... contracts involving both research and development and other work. 250.104-3-70 Section 250.104-3-70 Federal... MANAGEMENT EXTRAORDINARY CONTRACTUAL ACTIONS AND THE SAFETY ACT Extraordinary Contractual Actions 250.104-3-70 Indemnification under contracts involving both research and development and other work. When...

Effects of coarse grain size distribution and fine particle content on pore fluid pressure and shear behavior in experimental debris flows

NASA Astrophysics Data System (ADS)

Kaitna, Roland; Palucis, Marisa C.; Yohannes, Bereket; Hill, Kimberly M.; Dietrich, William E.

2016-02-01

Debris flows are typically a saturated mixture of poorly sorted particles and interstitial fluid, whose density and flow properties depend strongly on the presence of suspended fine sediment. Recent research suggests that grain size distribution (GSD) influences excess pore pressures (i.e., pressure in excess of predicted hydrostatic pressure), which in turn plays a governing role in debris flow behaviors. We report a series of controlled laboratory experiments in a 4 m diameter vertically rotating drum where the coarse particle size distribution and the content of fine particles were varied independently. We measured basal pore fluid pressures, pore fluid pressure profiles (using novel sensor probes), velocity profiles, and longitudinal profiles of the flow height. Excess pore fluid pressure was significant for mixtures with high fines fraction. Such flows exhibited lower values for their bulk flow resistance (as measured by surface slope of the flow), had damped fluctuations of normalized fluid pressure and normal stress, and had velocity profiles where the shear was concentrated at the base of the flow. These effects were most pronounced in flows with a wide coarse GSD distribution. Sustained excess fluid pressure occurred during flow and after cessation of motion. Various mechanisms may cause dilation and contraction of the flows, and we propose that the sustained excess fluid pressures during flow and once the flow has stopped may arise from hindered particle settling and yield strength of the fluid, resulting in transfer of particle weight to the fluid. Thus, debris flow behavior may be strongly influenced by sustained excess fluid pressures controlled by particle settling rates.

A concentrated parameter model for the human cardiovascular system including heart valve dynamics and atrioventricular interaction.

PubMed

Korakianitis, Theodosios; Shi, Yubing

2006-09-01

Numerical modeling of the human cardiovascular system has always been an active research direction since the 19th century. In the past, various simulation models of different complexities were proposed for different research purposes. In this paper, an improved numerical model to study the dynamic function of the human circulation system is proposed. In the development of the mathematical model, the heart chambers are described with a variable elastance model. The systemic and pulmonary loops are described based on the resistance-compliance-inertia concept by considering local effects of flow friction, elasticity of blood vessels and inertia of blood in different segments of the blood vessels. As an advancement from previous models, heart valve dynamics and atrioventricular interaction, including atrial contraction and motion of the annulus fibrosus, are specifically modeled. With these improvements the developed model can predict several important features that were missing in previous numerical models, including regurgitant flow on heart valve closure, the value of E/A velocity ratio in mitral flow, the motion of the annulus fibrosus (called the KG diaphragm pumping action), etc. These features have important clinical meaning and their changes are often related to cardiovascular diseases. Successful simulation of these features enhances the accuracy of simulations of cardiovascular dynamics, and helps in clinical studies of cardiac function.

Modifications to the 4x7 meter tunnel for acoustic research: Engineering feasibility study

NASA Technical Reports Server (NTRS)

1986-01-01

The NASA-Langley Research Center 4 x 7 Meter Low Speed Wind Tunnel is currently being used for low speed aerodynamics, V/STOL aerodynamics and, to a limited extent, rotorcraft noise research. The deficiencies of this wind tunnel for both aerodynamics and aeroacoustics research have been recognized for some time. Modifications to the wind tunnel are being made to improve the test section flow quality and to update the model cart systems. A further modification of the 4 x 7 Meter Wind Tunnel to permit rotorcraft model acoustics research has been proposed. As a precursor to the design of the proposed modifications, NASA is conducted both in-house and contracted studies to define the acoustic environment within the wind tunnel and to provide recommendations or the reduction of the wind tunnel background noise to a level acceptable to acoustics researchers. One of these studies by an acoustics consultant, has produced the primary reference documents that define the wind tunnel noise sources and outline recommended solutions.

Flow and active mixing have a strong impact on bacterial growth dynamics in the proximal large intestine

NASA Astrophysics Data System (ADS)

Cremer, Jonas; Segota, Igor; Yang, Chih-Yu; Arnoldini, Markus; Groisman, Alex; Hwa, Terence

2016-11-01

More than half of fecal dry weight is bacterial mass with bacterial densities reaching up to 1012 cells per gram. Mostly, these bacteria grow in the proximal large intestine where lateral flow along the intestine is strong: flow can in principal lead to a washout of bacteria from the proximal large intestine. Active mixing by contractions of the intestinal wall together with bacterial growth might counteract such a washout and allow high bacterial densities to occur. As a step towards understanding bacterial growth in the presence of mixing and flow, we constructed an in-vitro setup where controlled wall-deformations of a channel emulate contractions. We investigate growth along the channel under a steady nutrient inflow. Depending on mixing and flow, we observe varying spatial gradients in bacterial density along the channel. Active mixing by deformations of the channel wall is shown to be crucial in maintaining a steady-state bacterial population in the presence of flow. The growth-dynamics is quantitatively captured by a simple mathematical model, with the effect of mixing described by an effective diffusion term. Based on this model, we discuss bacterial growth dynamics in the human large intestine using flow- and mixing-behavior having been observed for humans.

48 CFR 35.001 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.001 Definitions. Applied research means the effort that (a) normally follows basic research, but may not be severable from the related basic research; (b) attempts to...

48 CFR 16.103 - Negotiating contract type.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Selecting Contract Types 16.103 Negotiating contract... basic profit motive of business enterprise, shall be used when the risk involved is minimal or can be...) Contracts on a firm fixed-price basis other than those for major systems or research and development, and (3...

48 CFR 917.7301-1 - General.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Section 917.7301-1 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Program Research and Development Announcements 917.7301-1... in entering into arrangements for research, development, and related projects in specified areas of...

Establishing guidelines for incentive/disincentive contracting at ODOT.

DOT National Transportation Integrated Search

2007-02-01

This report describes the results of a research project which explored the use of Incentive / Disincentive (I/D) contracting at : the Oregon Department of Transportation (ODOT). The research found that I/D contracting is a relatively rare practice : ...

Endothelium-dependent vasodilatation and exercise hyperaemia in ageing humans: impact of acute ascorbic acid administration

PubMed Central

Kirby, Brett S; Voyles, Wyatt F; Simpson, Carrie B; Carlson, Rick E; Schrage, William G; Dinenno, Frank A

2009-01-01

Age-related increases in oxidative stress impair endothelium-dependent vasodilatation in humans, leading to the speculation that endothelial dysfunction contributes to impaired muscle blood flow and vascular control during exercise in older adults. We directly tested this hypothesis in 14 young (22 ± 1 years) and 14 healthy older men and women (65 ± 2 years). We measured forearm blood flow (FBF; Doppler ultrasound) and calculated vascular conductance (FVC) responses to single muscle contractions at 10, 20 and 40% maximum voluntary contraction (MVC) before and during ascorbic acid (AA) infusion, and we also determined the effects of AA on muscle blood flow during mild (10% MVC) continuous rhythmic handgrip exercise. For single contractions, the peak rapid hyperaemic responses to all contraction intensities were impaired ∼45% in the older adults (all P < 0.05), and AA infusion did not impact the responses in either age group. For the rhythmic exercise trial, FBF (∼28%) and FVC (∼31%) were lower (P= 0.06 and 0.05) in older versus young adults after 5 min of steady-state exercise with saline. Subsequently, AA was infused via brachial artery catheter for 10 min during continued exercise. AA administration did not significantly influence FBF or FVC in young adults (1–3%; P= 0.24–0.59), whereas FBF increased 34 ± 7% in older adults at end-exercise, and this was due to an increase in FVC (32 ± 7%; both P < 0.05). This increase in FBF and FVC during exercise in older adults was associated with improvements in vasodilator responses to acetylcholine (ACh; endothelium dependent) but not sodium nitroprusside (SNP; endothelium independent). AA had no effect on ACh or SNP responses in the young. We conclude that acute AA administration does not impact the observed age-related impairment in the rapid hyperaemic response to brief muscle contractions in humans; however, it does significantly increase muscle blood flow during continuous dynamic exercise in older adults, and this is probably due (in part) to an improvement in endothelium-dependent vasodilatation. PMID:19307300

Annular Electric Discharge as an Initiator of Combustion in Supersonic Flow

DTIC Science & Technology

2009-02-01

Flow 5a. CONTRACT NUMBER ISTC Registration No: 3833P 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Kossyi Igor Antonovich...REPORT NUMBER(S) ISTC 07-7012 12. DISTRIBUTION/AVAILABILITY STATEMENT Approved for public release; distribution is unlimited. 13. SUPPLEMENTARY...

Noninvasive assessment of left atrial maximum dP/dt by a combination of transmitral and pulmonary venous flow.

PubMed

Nakatani, S; Garcia, M J; Firstenberg, M S; Rodriguez, L; Grimm, R A; Greenberg, N L; McCarthy, P M; Vandervoort, P M; Thomas, J D

1999-09-01

The study assessed whether hemodynamic parameters of left atrial (LA) systolic function could be estimated noninvasively using Doppler echocardiography. Left atrial systolic function is an important aspect of cardiac function. Doppler echocardiography can measure changes in LA volume, but has not been shown to relate to hemodynamic parameters such as the maximal value of the first derivative of the pressure (LA dP/dt(max)). Eighteen patients in sinus rhythm were studied immediately before and after open heart surgery using simultaneous LA pressure measurements and intraoperative transesophageal echocardiography. Left atrial pressure was measured with a micromanometer catheter, and LA dP/dt(max) during atrial contraction was obtained. Transmitral and pulmonary venous flow were recorded by pulsed Doppler echocardiography. Peak velocity, and mean acceleration and deceleration, and the time-velocity integral of each flow during atrial contraction was measured. The initial eight patients served as the study group to derive a multilinear regression equation to estimate LA dP/dt(max) from Doppler parameters, and the latter 10 patients served as the test group to validate the equation. A previously validated numeric model was used to confirm these results. In the study group, LA dP/dt(max) showed a linear relation with LA pressure before atrial contraction (r = 0.80, p < 0.005), confirming the presence of the Frank-Starling mechanism in the LA. Among transmitral flow parameters, mean acceleration showed the strongest correlation with LA dP/dt(max) (r = 0.78, p < 0.001). Among pulmonary venous flow parameters, no single parameter was sufficient to estimate LA dP/dt(max) with an r2 > 0.30. By stepwise and multiple linear regression analysis, LA dP/dt(max) was best described as follows: LA dP/dt(max) = 0.1 M-AC +/- 1.8 P-V - 4.1; r = 0.88, p < 0.0001, where M-AC is the mean acceleration of transmitral flow and P-V is the peak velocity of pulmonary venous flow during atrial contraction. This equation was tested in the latter 10 patients of the test group. Predicted and measured LA dP/dt(max) correlated well (r = 0.90, p < 0.0001). Numerical simulation verified that this relationship held across a wide range of atrial elastance, ventricular relaxation and systolic function, with LA dP/dt(max) predicted by the above equation with r = 0.94. A combination of transmitral and pulmonary venous flow parameters can provide a hemodynamic assessment of LA systolic function.

Noninvasive assessment of left atrial maximum dP/dt by a combination of transmitral and pulmonary venous flow

NASA Technical Reports Server (NTRS)

Nakatani, S.; Garcia, M. J.; Firstenberg, M. S.; Rodriguez, L.; Grimm, R. A.; Greenberg, N. L.; McCarthy, P. M.; Vandervoort, P. M.; Thomas, J. D.

1999-01-01

OBJECTIVES: The study assessed whether hemodynamic parameters of left atrial (LA) systolic function could be estimated noninvasively using Doppler echocardiography. BACKGROUND: Left atrial systolic function is an important aspect of cardiac function. Doppler echocardiography can measure changes in LA volume, but has not been shown to relate to hemodynamic parameters such as the maximal value of the first derivative of the pressure (LA dP/dt(max)). METHODS: Eighteen patients in sinus rhythm were studied immediately before and after open heart surgery using simultaneous LA pressure measurements and intraoperative transesophageal echocardiography. Left atrial pressure was measured with a micromanometer catheter, and LA dP/dt(max) during atrial contraction was obtained. Transmitral and pulmonary venous flow were recorded by pulsed Doppler echocardiography. Peak velocity, and mean acceleration and deceleration, and the time-velocity integral of each flow during atrial contraction was measured. The initial eight patients served as the study group to derive a multilinear regression equation to estimate LA dP/dt(max) from Doppler parameters, and the latter 10 patients served as the test group to validate the equation. A previously validated numeric model was used to confirm these results. RESULTS: In the study group, LA dP/dt(max) showed a linear relation with LA pressure before atrial contraction (r = 0.80, p < 0.005), confirming the presence of the Frank-Starling mechanism in the LA. Among transmitral flow parameters, mean acceleration showed the strongest correlation with LA dP/dt(max) (r = 0.78, p < 0.001). Among pulmonary venous flow parameters, no single parameter was sufficient to estimate LA dP/dt(max) with an r2 > 0.30. By stepwise and multiple linear regression analysis, LA dP/dt(max) was best described as follows: LA dP/dt(max) = 0.1 M-AC +/- 1.8 P-V - 4.1; r = 0.88, p < 0.0001, where M-AC is the mean acceleration of transmitral flow and P-V is the peak velocity of pulmonary venous flow during atrial contraction. This equation was tested in the latter 10 patients of the test group. Predicted and measured LA dP/dt(max) correlated well (r = 0.90, p < 0.0001). Numerical simulation verified that this relationship held across a wide range of atrial elastance, ventricular relaxation and systolic function, with LA dP/dt(max) predicted by the above equation with r = 0.94. CONCLUSIONS: A combination of transmitral and pulmonary venous flow parameters can provide a hemodynamic assessment of LA systolic function.

21 CFR 312.52 - Transfer of obligations to a contract research organization.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 5 2010-04-01 2010-04-01 false Transfer of obligations to a contract research organization. 312.52 Section 312.52 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... and Investigators § 312.52 Transfer of obligations to a contract research organization. (a) A sponsor...

Military Personnel Procurement Resources Report

DTIC Science & Technology

1991-05-28

directed at enlistment in the Military Service. Include cost of advertising agency contract spent on marketing research (to include cost of advertising...programs. Include cost of advertising agency contract spent on marketing research (to include cost of advertising agency subcontractors). 7. Printed...Include cost of advertising agency contract spent on marketing research (to include cost of advertising agency sub- contractors). 7. Printed

Policy Development for Research Grants, and Contracts Administration in the Small College or University.

ERIC Educational Resources Information Center

Lyons, Paul R.

Some of the major administrative factors that will require attention by small colleges and universities as they develop policy and general procedures for the administration of research, grants, and contracts are considered. Management of research, grants, and contracts is a process that involves the review and approval of proposals; project…

13 CFR 124.503 - How does SBA accept a procurement for award through the 8(a) BD program?

Code of Federal Regulations, 2011 CFR

2011-01-01

... market research, the contracting officer shall first consider a set-aside or sole source award (if the... market research conducted. In addition, the contracting officer must document the contract file showing... factors such as the results of market research, programmatic needs specific to the procuring agency...

Zonal-flow dynamics from a phase-space perspective

NASA Astrophysics Data System (ADS)

Ruiz, D. E.; Parker, J. B.; Shi, E. L.; Dodin, I. Y.

2017-10-01

The wave kinetic equation (WKE) describing drift-wave (DW) turbulence is widely used in the studies of zonal flows (ZFs) emerging from DW turbulence. However, this formulation neglects the exchange of enstrophy between DWs and ZFs and also ignores effects beyond the geometrical-optics (GO) limit. Here we present a new theory that captures both of these effects, while still treating DW quanta (``driftons'') as particles in phase space. In this theory, the drifton dynamics is described by an equation of the Wigner-Moyal type, which is analogous to the phase-space formulation of quantum mechanics. The ``Hamiltonian'' and the ``dissipative'' parts of the DW-ZF interactions are clearly identified. Moreover, this theory can be interpreted as a phase-space representation of the second-order cumulant expansion (CE2). In the GO limit, this formulation features additional terms missing in the traditional WKE that ensure conservation of the total enstrophy of the system, in addition to the total energy, which is the only conserved invariant in previous theories based on the traditional WKE. Numerical simulations are presented to illustrate the importance of these additional terms. Supported by the U.S. DOE through Contract Nos. DE-AC02-09CH11466 and DE-AC52-07NA27344, by the NNSA SSAA Program through DOE Research Grant No. DE-NA0002948, and by the U.S. DOD NDSEG Fellowship through Contract No. 32-CFR-168a.

Defining Platelet Function During Polytrauma

DTIC Science & Technology

2013-02-01

calibrated automated thrombography, 3. Platelet-induced clot contraction and using viscoelastic measures such as TEG with Platelet Mapping™ and, 4. Flow...using calibrated automated thrombography (CAT). 3. Platelet-induced clot contraction and using viscoelastic measures such as TEG with Platelet Mapping...formation (such as Hemodyne’s platelet contractile force measurement and thromboelastrography). The degree to which certain injury patterns as well as

Parametric Study of Advanced Mixing of Fuel/Oxidant System in High Speed Gaseous Flows and Experimental Validation Planning

DTIC Science & Technology

2001-08-30

Body with Thermo-Chemical destribution of Heat-Protected System . In: Physical and Gasdynamic Phenomena in Supersonic Flows Over Bodies. Edit. By...Final Report on ISTC Contract # 1809p Parametric Study of Advanced Mixing of Fuel/Oxidant System in High Speed Gaseous Flows and Experimental...of Advanced Mixing of Fuel/Oxidant System in High Speed Gaseous Flows and Experimental Validation Planning 5c. PROGRAM ELEMENT NUMBER 5d. PROJECT

48 CFR 235.001 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 235.001 Definitions. “Research and development” means those efforts described by the Research, Development, Test, and Evaluation...

Model of Transition from Laminar to Turbulent Flow

NASA Astrophysics Data System (ADS)

Kanda, Hidesada

2001-11-01

For circular pipe flows, a model of transition from laminar to turbulent flow has already been proposed and the minimum critical Reynolds number of approximately 2040 was obtained (Kanda, 1999). In order to prove the validity of the model, another verification is required. Thus, for plane Poiseuille flow, results of previous investigations were studied, focusing on experimental data on the critical Reynolds number Rc, the entrance length, and the transition length. Consequently, concerning the natural transition, it was confirmed from the experimental data that (i) the transition occurs in the entrance region, (ii) Rc increases as the contraction ratio in the inlet section increases, and (iii) the minimum Rc is obtained when the contraction ratio is the smallest or one, and there is no-bellshaped entrance or straight parallel plates. Its value exists in the neighborhood of 1300, based on the channel height and the average velocity. Although, for Hagen-Poiseuille flow, the minimum Rc is approximately 2000, based on the pipe diameter and the average velocity, there seems to be no significant difference in the transition from laminar to turbulent flow between Hagen-Poiseuille flow and plane Poiseuille flow (Kanda, 2001). Rc is determined by the shape of the inlet. Kanda, H., 1999, Proc. of ASME Fluids Engineering Division - 1999, FED-Vol. 250, pp. 197-204. Kanda, H., 2001, Proc. of ASME Fluids Engineering Division - 2001.

The numerical modeling of water/FMWCNT nanofluid flow and heat transfer in a backward-facing contracting channel

NASA Astrophysics Data System (ADS)

Alrashed, Abdullah A. A. A.; Akbari, Omid Ali; Heydari, Ali; Toghraie, Davood; Zarringhalam, Majid; Shabani, Gholamreza Ahmadi Sheikh; Seifi, Ali Reza; Goodarzi, Marjan

2018-05-01

In recent years, the study of rheological behavior and heat transfer of nanofluids in the industrial equipment has become widespread among the researchers and their results have led to great advancements in this field. In present study, the laminar flow and heat transfer of water/functional multi-walled carbon nanotube nanofluid have been numerically investigated in weight percentages of 0.00, 0.12 and 0.25 and Reynolds numbers of 1-150 by using finite volume method (FVM). The analyzed geometry is a two-dimensional backward-facing contracting channel and the effects of various weight percentages and Reynolds numbers have been studied in the supposed geometry. The results have been interpreted as the figures of Nusselt number, friction coefficient, pressure drop, velocity contours and static temperature. The results of this research indicate that, the enhancement of Reynolds number or weight percentage of nanoparticles causes the reduction of surface temperature and the enhancement of heat transfer coefficient. By increasing Reynolds number, the axial velocity enhances, causing the enhancement of momentum. By increasing fluid momentum at the beginning of channel, especially in areas close to the upper wall, the axial velocity reduces and the possibility of vortex generation increases. The mentioned behavior causes a great enhancement in velocity gradients and pressure drop at the inlet of channel. Also, in these areas, Nusselt number and local friction coefficient figures have a relative decline, which is due to the sudden reduction of velocity. In general, by increasing the mass fraction of solid nanoparticles, the average Nusselt number increases and in Reynolds number of 150, the enhancement of pumping power and pressure drop does not cause any significant changes. This behavior is an important advantage of choosing nanofluid which causes the enhancement of thermal efficiency.

17 CFR Appendix C - Demonstration of Compliance That a Contract Is Not Readily Susceptible to Manipulation

Code of Federal Regulations, 2014 CFR

2014-04-01

... contract market. When designing a futures contract, the designated contract market should conduct market research so that the contract design meets the risk management needs of prospective users and promotes... users to obtain their views and opinions during the contract design process to ensure the contract's...

Non-isothermal electro-osmotic flow in a microchannel with charge-modulated surfaces

NASA Astrophysics Data System (ADS)

Bautista, Oscar; Sanchez, Salvador; Mendez, Federico

2015-11-01

In this work, we present an theoretical analysis of a nonisothermal electro-osmotic flow of a Newtonian fluid over charge-modulated surfaces in a microchannel. Here, the heating in the microchannel is due to the Joule effect caused by the imposition of an external electric field. The study is conducted through the use of perturbation techniques and is validated by means of numerical simulations. We consider that both, viscosity and electrical conductivity of the fluid are temperature-dependent; therefore, in order to determine the heat transfer process and the corresponding effects on the flow field, the governing equations of continuity, momentum, energy and electric potential have to be solved in a coupled manner. The principal obtained results evidence that the flow patterns are perturbed in a noticeable manner in comparison with the isothernal case. Our results may be used for increasing microfluidics mixing by conjugating thermal effects with the use of charge-modulated surfaces. This work has been supported by the research grants no. 220900 of Consejo Nacional de Ciencia y Tecnología (CONACYT) and 20150919 of SIP-IPN at Mexico. F. Méndez acknowledges also the economical support of PAPIIT-UNAM under contract number IN112215.

Fully resolved simulations of expansion waves propagating into particle beds

NASA Astrophysics Data System (ADS)

Marjanovic, Goran; Hackl, Jason; Annamalai, Subramanian; Jackson, Thomas; Balachandar, S.

2017-11-01

There is a tremendous amount of research that has been done on compression waves and shock waves moving over particles but very little concerning expansion waves. Using 3-D direct numerical simulations, this study will explore expansion waves propagating into fully resolved particle beds of varying volume fractions and geometric arrangements. The objectives of these simulations are as follows: 1) To fully resolve all (1-way coupled) forces on the particles in a time varying flow and 2) to verify state-of-the-art drag models for such complex flows. We will explore a range of volume fractions, from very low ones that are similar to single particle flows, to higher ones where nozzling effects are observed between neighboring particles. Further, we will explore two geometric arrangements: body centered cubic and face centered cubic. We will quantify the effects that volume fraction and geometric arrangement plays on the drag forces and flow fields experienced by the particles. These results will then be compared to theoretical predictions from a model based on the generalized Faxen's theorem. This work was supported in part by the U.S. Department of Energy under the Predictive Science Academic Alliance Program, under Contract No. DE-NA0002378.

Mechanical Control of Tissue Morphogenesis

PubMed Central

Patwari, Parth; Lee, Richard T.

2008-01-01

Mechanical forces participate in morphogenesis from the level of individual cells to whole organism patterning. This manuscript reviews recent research that has identified specific roles for mechanical forces in important developmental events. One well-defined example is that dynein-driven cilia create fluid flow that determines left-right patterning in the early mammalian embryo. Fluid flow is also important for vasculogenesis, and evidence suggests that fluid shear stress rather than fluid transport is primarily required for remodeling the early vasculature. Contraction of the actin cytoskeleton, driven by nonmuscle myosins and regulated by the Rho family GTPases, is a recurring mechanism for controlling morphogenesis throughout development, from gastrulation to cardiogenesis. Finally, novel experimental approaches suggest critical roles for the actin cytoskeleton and the mechanical environment in determining differentiation of mesenchymal stem cells. Insights into the mechanisms linking mechanical forces to cell and tissue differentiation pathways are important for understanding many congenital diseases and for developing regenerative medicine strategies. PMID:18669930

Control of shock wave-boundary layer interactions by bleed in supersonic mixed compression inlets

NASA Technical Reports Server (NTRS)

Fukuda, M. K.; Hingst, W. G.; Reshotko, E.

1975-01-01

An experimental investigation was conducted to determine the effect of bleed on a shock wave-boundary layer interaction in an axisymmetric mixed-compression supersonic inlet. The inlet was designed for a free-stream Mach number of 2.50 with 60-percent supersonic internal area contraction. The experiment was conducted in the NASA Lewis Research Center 10-Foot Supersonic Wind Tunnel. The effects of bleed amount and bleed geometry on the boundary layer after a shock wave-boundary layer interaction were studied. The effect of bleed on the transformed form factor is such that the full realizable reduction is obtained by bleeding of a mass flow equal to about one-half of the incident boundary layer mass flow. More bleeding does not yield further reduction. Bleeding upstream or downstream of the shock-induced pressure rise is preferable to bleeding across the shock-induced pressure rise.

AREVA Team Develops Sump Strainer Blockage Solution for PWRs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Phan, Ray

2006-07-01

The purpose of this paper is to discuss the methodology, testing challenges, and results of testing that a team of experts from Areva NP, Alden Research Laboratory, Inc (ALDEN), and Performance Contracting Inc. (PCI) has developed. The team is currently implementing a comprehensive solution to the issue of Emergency Core Cooling System (ECCS) sump strainer blockage facing Pressurized Water Reactor (PWR) Nuclear Plants. The team has successfully demonstrated two key results from the testing of passive Sure-FlowTM strainers, which were designed to distribute the required flow over a large surface area resulting in extremely low approach velocities. First, the actualmore » head loss (pressure drop) as tested, across the prototype strainers, was much lower than the calculated head loss using the Nuclear Regulatory Commission (NRC) approved NUREG/CR-6224 head loss correlation. Second, the penetration fractions were much lower than those seen in the NRC sponsored debris penetration tests. (author)« less

Superhydrophobic and polymer drag reduction in turbulent Taylor-Couette flow

NASA Astrophysics Data System (ADS)

Rajappan, Anoop; McKinley, Gareth H.

2017-11-01

We use a custom-built Taylor-Couette apparatus (radius ratio η = 0.75) to study frictional drag reduction by dilute polymer solutions and superhydrophobic (SH) surfaces in turbulent flows for 15000 < Re < 86000 . By monitoring the torque-speed scaling we show that the swirling flow becomes fully turbulent above Re = 15000 and we focus on measurements in this regime. By applying SH coatings on the inner cylinder, we can evaluate the drag reducing performance of the coating and calculate the effective slip length in turbulent flow using a suitably modified Prandtl-von Kármán analysis. We also investigate drag reduction by dilute polymer solutions, and show that natural biopolymers from plant mucilage can be an inexpensive and effective alternative to synthetic polymers in drag reduction applications, approaching the same maximum drag reduction asymptote. Finally we explore combinations of the two methods - one arising from wall slip and the other due to changes in turbulence dynamics in the bulk flow - and find that the two effects are not additive; interestingly, the effectiveness of polymer drag reduction is drastically reduced in the presence of an SH coating on the wall. This study was financially supported by the Office of Naval Research (ONR) through Contract No. 3002453814.

48 CFR 935.070 - Research misconduct.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Research misconduct. 935... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 935.070 Research misconduct. (a) Applicability. The DOE research misconduct policy set forth at 10 CFR part 733 addresses research misconduct by individuals who...

48 CFR 935.070 - Research misconduct.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Research misconduct. 935... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 935.070 Research misconduct. (a) Applicability. The DOE research misconduct policy set forth at 10 CFR part 733 addresses research misconduct by individuals who...

48 CFR 935.070 - Research misconduct.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Research misconduct. 935... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 935.070 Research misconduct. (a) Applicability. The DOE research misconduct policy set forth at 10 CFR part 733 addresses research misconduct by individuals who...

48 CFR 935.070 - Research misconduct.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Research misconduct. 935... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 935.070 Research misconduct. (a) Applicability. The DOE research misconduct policy set forth at 10 CFR part 733 addresses research misconduct by individuals who...

48 CFR 935.070 - Research misconduct.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Research misconduct. 935... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 935.070 Research misconduct. (a) Applicability. The DOE research misconduct policy set forth at 10 CFR part 733 addresses research misconduct by individuals who...

48 CFR 32.403 - Applicability.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., research, or development work with nonprofit educational or research institutions. (b) Contracts solely for... could not be expected to suitably administer a guaranteed loan. (g) Contracts with small business... contract financing method for both the Government and the contractor. [48 FR 42328, Sept. 19, 1983, as...

48 CFR 917.7300 - Scope of subpart.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Section 917.7300 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Program Research and Development Announcements 917.7300 Scope of subpart. (a) This subpart discusses the policy for the use of a program research and development...

48 CFR 731.773 - Independent research and development costs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Independent research and development costs. 731.773 Section 731.773 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT GENERAL CONTRACTING REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With Nonprofit...

48 CFR 731.773 - Independent research and development costs.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Independent research and development costs. 731.773 Section 731.773 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT GENERAL CONTRACTING REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With Nonprofit...

40 CFR 63.323 - Test methods and monitoring.

Code of Federal Regulations, 2012 CFR

2012-07-01

... downstream from any flow disturbance such as a bend, expansion, contraction, or outlet; downstream from no other inlet; and 2 stack or duct diameters upstream from any flow disturbance such as a bend, expansion... monitoring by inserting the colorimetric detector or PCE gas analyzer tube into the open space above the...

40 CFR 63.323 - Test methods and monitoring.

Code of Federal Regulations, 2014 CFR

2014-07-01

... downstream from any flow disturbance such as a bend, expansion, contraction, or outlet; downstream from no other inlet; and 2 stack or duct diameters upstream from any flow disturbance such as a bend, expansion... monitoring by inserting the colorimetric detector or PCE gas analyzer tube into the open space above the...

40 CFR 63.323 - Test methods and monitoring.

Code of Federal Regulations, 2013 CFR

2013-07-01

... downstream from any flow disturbance such as a bend, expansion, contraction, or outlet; downstream from no other inlet; and 2 stack or duct diameters upstream from any flow disturbance such as a bend, expansion... monitoring by inserting the colorimetric detector or PCE gas analyzer tube into the open space above the...

Hemispherical array of sensors with contractively wrapped polymer petals for flow sensing

NASA Astrophysics Data System (ADS)

Kanhere, Elgar; Wang, Nan; Kottapalli, Ajay Giri Prakash; Miao, Jianmin; Triantafyllou, Michael

2017-11-01

Hemispherical arrays have inherent advantages that allow simultaneous detection of flow speed and direction due to their shape. Though MEMS technology has progressed leaps and bounds, fabrication of array of sensors on a hemispherical surface is still a challenge. In this work, a novel approach of constructing hemispherical array is presented which employs a technique of contractively wrapping a hemispherical surface with flexible liquid crystal polymer petals. This approach also leverages the offerings from rapid prototyping technology and established standard MEMS fabrication processes. Hemispherical arrays of piezoresistive sensors are constructed with two types of petal wrappings, 4-petals and 8-petals, on a dome. The flow sensing and direction detection abilities of the dome are evaluated through experiments in wind tunnel. Experimental results demonstrate that a dome equipped with a dense array of sensors can provide information pertaining to the stimulus, through visualization of output profile over the entire surface.

The microwell control of embryoid body size in order to regulate cardiac differentiation of human embryonic stem cells.

PubMed

Mohr, Jeffrey C; Zhang, Jianhua; Azarin, Samira M; Soerens, Andrew G; de Pablo, Juan J; Thomson, James A; Lyons, Gary E; Palecek, Sean P; Kamp, Timothy J

2010-03-01

The differentiation of human embryonic stem cells (hESCs) into cardiomyocytes (CMs) using embryoid bodies (EBs) is relatively inefficient and highly variable. Formation of EBs using standard enzymatic disaggregation techniques results in a wide range of sizes and geometries of EBs. Use of a 3-D cuboidal microwell system to culture hESCs in colonies of defined dimensions, 100-500 microm in lateral dimensions and 120 microm in depth, enabled formation of more uniform-sized EBs. The 300 microm microwells produced highest percentage of contracting EBs, but flow cytometry for myosin light chain 2A (MLC2a) expressing cells revealed a similar percentage (approximately 3%) of cardiomyocytes formed in EBs from 100 microm to 300 microm microwells. These data, and immunolabeling with anti-MF20 and MLC2a, suggest that the smaller EBs are less likely to form contracting EBs, but those contracting EBs are relatively enriched in cardiomyocytes compared to larger EB sizes where CMs make up a proportionately smaller fraction of the total cells. We conclude that microwell-engineered EB size regulates cardiogenesis and can be used for more efficient and reproducible formation of hESC-CMs needed for research and therapeutic applications. (c) 2009 Elsevier Ltd. All rights reserved.

Relationship between ultrasonically detected phasic antral contractions and antral pressure.

PubMed

Hveem, K; Sun, W M; Hebbard, G; Horowitz, M; Doran, S; Dent, J

2001-07-01

The relationships between gastric wall motion and intraluminal pressure are believed to be major determinants of flows within and from the stomach. Gastric antral wall motion and intraluminal pressures were monitored in five healthy subjects by concurrent antropyloroduodenal manometry and transabdominal ultrasound for 60 min after subjects drank 500 ml of clear soup. We found that 99% of antral contractions detected by ultrasound were propagated aborally, and 68% of contractions became lumen occlusive at the site of the ultrasound marker. Of the 203 contractions detected by ultrasound, 53% were associated with pressure events in the manometric reference channel; 86% of contractions had corresponding pressure events detectable somewhere in the antrum. Contractions that occluded the lumen were more likely to be associated with a pressure event in the manometric reference channel (P < 0.01) and to be of greater amplitude (P < 0.01) than non-lumen-occlusive contractions. We conclude that heterogeneous pressure event patterns in the antrum occur despite a stereotyped pattern of contraction propagation seen on ultrasound. Lumen occlusion is more likely to be associated with higher peak antral pressure events.

Influence of cerebral blood vessel movements on the position of perivascular synapses.

PubMed

Urrecha, Miguel; Romero, Ignacio; DeFelipe, Javier; Merchán-Pérez, Angel

2017-01-01

Synaptic activity is regulated and limited by blood flow, which is controlled by blood vessel dilation and contraction. Traditionally, the study of neurovascular coupling has mainly focused on energy consumption and oxygen delivery. However, the mechanical changes that blood vessel movements induce in the surrounding tissue have not been considered. We have modeled the mechanical changes that movements of blood vessels cause in neighboring synapses. Our simulations indicate that synaptic densities increase or decrease during vascular dilation and contraction, respectively, near the blood vessel walls. This phenomenon may alter the concentration of neurotransmitters and vasoactive substances in the immediate vicinity of the vessel wall and thus may have an influence on local blood flow.

42 CFR 67.103 - Peer review of contract proposals.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 67.103 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING AGENCY FOR HEALTH CARE POLICY AND RESEARCH GRANTS AND CONTRACTS Peer Review of Contracts for Health Services Research, Evaluation, Demonstration, and Dissemination Projects § 67.103 Peer...

75 FR 10567 - Commerce Acquisition Regulation (CAR)

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-08

... acquisitions, contract financing, protests, disputes, and appeals, major system acquisitions, research and... appeals. SUBCHAPTER F--SPECIAL CATEGORIES OF CONTRACTING 1334 Major system acquisition. 1335 Research and....603-2, selection of contracting officers shall be based upon Section 4 of CAM 1301.6. 1301.603-3...

48 CFR 1435.010 - Scientific and technical reports.

Code of Federal Regulations, 2010 CFR

2010-10-01

... SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1435.010 Scientific and technical reports. If a Research and Development (R&D) contract results involve classified or national security... available. Copies of publications and reports are also required to be sent to the DOI Departmental Library...

48 CFR 1435.010 - Scientific and technical reports.

Code of Federal Regulations, 2013 CFR

2013-10-01

... SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1435.010 Scientific and technical reports. If a Research and Development (R&D) contract results involve classified or national security... available. Copies of publications and reports are also required to be sent to the DOI Departmental Library...

48 CFR 1435.010 - Scientific and technical reports.

Code of Federal Regulations, 2011 CFR

2011-10-01

... SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1435.010 Scientific and technical reports. If a Research and Development (R&D) contract results involve classified or national security... available. Copies of publications and reports are also required to be sent to the DOI Departmental Library...

48 CFR 1435.010 - Scientific and technical reports.

Code of Federal Regulations, 2012 CFR

2012-10-01

... SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1435.010 Scientific and technical reports. If a Research and Development (R&D) contract results involve classified or national security... available. Copies of publications and reports are also required to be sent to the DOI Departmental Library...

48 CFR 1435.010 - Scientific and technical reports.

Code of Federal Regulations, 2014 CFR

2014-10-01

... SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1435.010 Scientific and technical reports. If a Research and Development (R&D) contract results involve classified or national security... available. Copies of publications and reports are also required to be sent to the DOI Departmental Library...

High Speed Research Noise Prediction Code (HSRNOISE) User's and Theoretical Manual

NASA Technical Reports Server (NTRS)

Golub, Robert (Technical Monitor); Rawls, John W., Jr.; Yeager, Jessie C.

2004-01-01

This report describes a computer program, HSRNOISE, that predicts noise levels for a supersonic aircraft powered by mixed flow turbofan engines with rectangular mixer-ejector nozzles. It fully documents the noise prediction algorithms, provides instructions for executing the HSRNOISE code, and provides predicted noise levels for the High Speed Research (HSR) program Technology Concept (TC) aircraft. The component source noise prediction algorithms were developed jointly by Boeing, General Electric Aircraft Engines (GEAE), NASA and Pratt & Whitney during the course of the NASA HSR program. Modern Technologies Corporation developed an alternative mixer ejector jet noise prediction method under contract to GEAE that has also been incorporated into the HSRNOISE prediction code. Algorithms for determining propagation effects and calculating noise metrics were taken from the NASA Aircraft Noise Prediction Program.

Identification of Location Specific Feature Points in a Cardiac Cycle Using a Novel Seismocardiogram Spectrum System.

PubMed

Lin, Wen-Yen; Chou, Wen-Cheng; Chang, Po-Cheng; Chou, Chung-Chuan; Wen, Ming-Shien; Ho, Ming-Yun; Lee, Wen-Chen; Hsieh, Ming-Jer; Lin, Chung-Chih; Tsai, Tsai-Hsuan; Lee, Ming-Yih

2018-03-01

Seismocardiogram (SCG) or mechanocardiography is a noninvasive cardiac diagnostic method; however, previous studies used only a single sensor to detect cardiac mechanical activities that will not be able to identify location-specific feature points in a cardiac cycle corresponding to the four valvular auscultation locations. In this study, a multichannel SCG spectrum measurement system was proposed and examined for cardiac activity monitoring to overcome problems like, position dependency, time delay, and signal attenuation, occurring in traditional single-channel SCG systems. ECG and multichannel SCG signals were simultaneously recorded in 25 healthy subjects. Cardiac echocardiography was conducted at the same time. SCG traces were analyzed and compared with echocardiographic images for feature point identification. Fifteen feature points were identified in the corresponding SCG traces. Among them, six feature points, including left ventricular lateral wall contraction peak velocity, septal wall contraction peak velocity, transaortic peak flow, transpulmonary peak flow, transmitral ventricular relaxation flow, and transmitral atrial contraction flow were identified. These new feature points were not observed in previous studies because the single-channel SCG could not detect the location-specific signals from other locations due to time delay and signal attenuation. As the results, the multichannel SCG spectrum measurement system can record the corresponding cardiac mechanical activities with location-specific SCG signals and six new feature points were identified with the system. This new modality may help clinical diagnoses of valvular heart diseases and heart failure in the future.

48 CFR 1335.017 - Federal funded research and development centers.

Code of Federal Regulations, 2010 CFR

2010-10-01

... OF COMMERCE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1335.017 Federal funded research and development centers. ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Federal funded research...

Evaluation of contract time estimation and contracting procedures : technical summary.

DOT National Transportation Integrated Search

1996-08-01

The objective of this research was 1) to provide the DOTD with a systematic approach to the determination of contract duration, and 2) to explore innovative contracting procedures that may prove beneficial in DOTD projects. The innovative contracting...

Level II scour analysis for Bridge 8 (BARTTH00020008) on Town Highway 2, crossing Roaring Brook, Barton, Vermont

USGS Publications Warehouse

Boehmler, Erick M.; Ivanoff, Michael A.

1996-01-01

Total scour at a highway crossing is comprised of three components: 1) long-term aggradation or degradation; 2) contraction scour (due to reduction in flow area caused by a bridge) and; 3) local scour (caused by accelerated flow around piers and abutments). Total scour is the sum of the three components. Equations are available to compute scour depths for contraction and local scour and a summary of the results follows. Contraction scour for all modelled flows ranged from 1.4 to 2.8 feet and the worst-case contraction scour occurred at the 500-year discharge. Abutment scour ranged from 8.5 to 16.5 feet and the worst-case abutment scour occurred at the 500-year discharge. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A cross-section of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1995, p. 47). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

Deep Throttle Turbopump Technology Testing

NASA Technical Reports Server (NTRS)

Ferguson, T. V.; Guinzburg, A.; McGlynn, R. D.; Williams, M.

2002-01-01

The objectives of this viewgraph presentation were to: (1) enhance and demonstrate critical technologies in support of planned RBCC flight test programs; and (2) obtain knowledge of wide flow range as it is applicable to liquid rocket engine turbopumps operating over extreme throttle ranges. This program was set up to demonstrate wide flow range diffuser technologies. The testing phase of the contract to provide data to anchor initial designs was partially successful. Data collected suggest flow phenomena exists at off-design flow rates.

Reduced Gravity Gas and Liquid Flows: Simple Data for Complex Problems

NASA Technical Reports Server (NTRS)

McQuillen, John; Motil, Brian

2001-01-01

While there have been many studies for two-phase flow through straight cylindrical tubes, more recently, a new group of studies have emerged that examine two-phase flow through non-straight, non-cylindrical geometries, including expansions, contractions, tees, packed beds and cyclonic separation devices. Although these studies are still, relatively speaking, in their infancy, they have provided valuable information regarding the importance of the flow momentum, and the existence of liquid dryout due to sharp comers in microgravity.

Labor Costs in DoD Contracts.

DTIC Science & Technology

1985-08-01

Labor Costs in 000 Contracts HQ DA, ATTN: DACA -BUZ-X (Mr. Walker) HQ DA, ATTN: DACA -OM1Z-B (Mr. Olson) HQ DA, ATTN: DACS-DPZ-B (Dr. Bellaschi) Defense...counterparts and if so, recommend corrective action . C. APPROACH. In addition to reviewing current methods used to monitor and control labor costs, a...Compensation Related Actions .................................... 27 6. Compensation Data Information Flow .................................. 32 V

48 CFR 970.5235-1 - Federally funded research and development center sponsoring agreement.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Solicitation Provisions and Contract Clauses for Management and Operating Contracts 970.5235-1... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Federally funded research...

Heat Extraction from a Hydraulically Fractured Penny-Shaped Crack in Hot Dry Rock

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abe, H.; Mura, T.; Keer, L.M.

1976-12-01

Heat extraction from a penny-shaped crack having both inlet and outlet holes is investigated analytically by considering the hydraulic and thermal growth of the crack when fluid is injected at a constant flow rate. The rock mass is assumed to be infinitely extended, homogeneous, and isotropic. The equations for fluid flow are derived and solved to determine the flow pattern in the crack. Temperature distributions in both rock and fluid are also determined. The crack width change due to thermal contraction and the corresponding flow rate increase are discussed. Some numerical calculations of outlet temperature, thermal power extraction, and crackmore » opening displacement due to thermal contraction of rocks are presented for cracks after they attain stationary states for given inlet flow rate and outlet suction pressure. The present paper is a further development of the previous works of Bodvarsson (1969), Gringarten et al. (1975), Lowell (1976), Harlow and Pracht (1972), McFarland (1975), among others, and considers the two-dimensional rather than the one-dimensional crack. Furthermore, the crack radius and width are quantities to be determined rather than given a priori. 11 refs., 1 tab., 5 figs.« less

A Continuous-Flow Polymerase Chain Reaction Microchip With Regional Velocity Control

PubMed Central

Li, Shifeng; Fozdar, David Y.; Ali, Mehnaaz F.; Li, Hao; Shao, Dongbing; Vykoukal, Daynene M.; Vykoukal, Jody; Floriano, Pierre N.; Olsen, Michael; McDevitt, John T.; Gascoyne, Peter R.C.; Chen, Shaochen

2009-01-01

This paper presents a continuous-flow polymerase chain reaction (PCR) microchip with a serpentine microchannel of varying width for “regional velocity control.” Varying the channel width by incorporating expanding and contracting conduits made it possible to control DNA sample velocities for the optimization of the exposure times of the sample to each temperature phase while minimizing the transitional periods during temperature transitions. A finite element analysis (FEA) and semi-analytical heat transfer model was used to determine the distances between the three heating assemblies that are responsible for creating the denaturation (96 °C), hybridization (60 °C), and extension (72 °C) temperature zones within the microchip. Predictions from the thermal FEA and semi-analytical model were compared with temperature measurements obtained from an infrared (IR) camera. Flow-field FEAs were also performed to predict the velocity distributions in the regions of the expanding and contracting conduits to study the effects of the microchannel geometry on flow recirculation and bubble nucleation. The flow fields were empirically studied using micro particle image velocimetry (μ-PIV) to validate the flow-field FEA’s and to determine experimental velocities in each of the regions of different width. Successful amplification of a 90 base pair (bp) bacillus anthracis DNA fragment was achieved. PMID:19829760

Understanding L-H transition in tokamak fusion plasmas

NASA Astrophysics Data System (ADS)

Xu, Guosheng; Wu, Xingquan

2017-03-01

This paper reviews the current state of understanding of the L-H transition phenomenon in tokamak plasmas with a focus on two central issues: (a) the mechanism for turbulence quick suppression at the L-H transition; (b) the mechanism for subsequent generation of sheared flow. We briefly review recent advances in the understanding of the fast suppression of edge turbulence across the L-H transition. We uncover a comprehensive physical picture of the L-H transition by piecing together a number of recent experimental observations and insights obtained from 1D and 2D simulation models. Different roles played by diamagnetic mean flow, neoclassical-driven mean flow, turbulence-driven mean flow, and turbulence-driven zonal flows are discussed and clarified. It is found that the L-H transition occurs spontaneously mediated by a shift in the radial wavenumber spectrum of edge turbulence, which provides a critical evidence for the theory of turbulence quench by the flow shear. Remaining questions and some key directions for future investigations are proposed. This work was supported by National Magnetic Confinement Fusion Science Program of China under Contracts No. 2015GB101000, No. 2013GB106000, and No. 2013GB107000 and National Natural Science Foundation of China under Contracts No. 11575235 and No. 11422546.

Impact of increased patient choice of providers in Sweden: cataract surgery.

PubMed

Hanning, Marianne; Åhs, Annika; Winblad, Ulrika; Lundström, Mats

2012-04-01

Choice of provider was introduced in Sweden in 2001. Our aim was to describe the scope and character of patient flows and to analyze any differences between patients who chose to move outside of their home county (movers) and those who did not (non-movers) with regard to age, sex, waiting time and level of need. Use of cataract operations between 2005 and 2008 based on data from the National Cataract Register. Data were analysed using descriptive statistics, odds ratios and multivariate regression analysis to compare movers and non-movers. Information on contracting between county councils and providers in other counties was obtained from a survey. Only 4% of cataract patients were treated by a provider outside their home county. Patient flows were mainly determined by contracts between county councils and providers, and only 1% were considered to be 'true' movers (i.e. patients who were not part of any special contracting agreement). Movers differed from non-movers in that they were on average younger, had less serious visual problems and had shorter waiting times. Though patient flows are minor in scope, the possibility of changing provider has probably been important in tackling long waits in some counties. However, the reform may threaten the equity of health care use.

Regulation of phosphorylase kinase by low concentrations of Ca ions upon muscle contraction: the connection between metabolism and muscle contraction and the connection between muscle physiology and Ca-dependent signal transduction.

PubMed

Ozawa, Eijiro

2011-01-01

It had long been one of the crucial questions in muscle physiology how glycogenolysis is regulated in connection with muscle contraction, when we found the answer to this question in the last half of the 1960s. By that time, the two principal currents of muscle physiology, namely, the metabolic flow starting from glycogen and the mechanisms of muscle contraction, had already been clarified at the molecular level thanks to our senior researchers. Thus, the final question we had to answer was how to connect these two currents. We found that low concentrations of Ca ions (10(-7)-10(-4) M) released from the sarcoplasmic reticulum for the regulation of muscle contraction simultaneously reversibly activate phosphorylase kinase, the enzyme regulating glycogenolysis. Moreover, we found that adenosine 3',5'-monophosphate (cyclic AMP), which is already known to activate muscle phosphorylase kinase, is not effective in the absence of such concentrations of Ca ions. Thus, cyclic AMP is not effective by itself alone and only modifies the activation process in the presence of Ca ions (at that time, cyclic AMP-dependent protein kinase had not yet been identified). After a while, it turned out that our works have not only provided the solution to the above problem on muscle physiology, but have also been considered as the first report of Ca-dependent protein phosphorylation, which is one of the central problems in current cell biology. Phosphorylase kinase is the first protein kinase to phosphorylate a protein resulting in the change in the function of the phosphorylated protein, as shown by Krebs and Fischer. Our works further showed that this protein kinase is regulated in a Ca-dependent manner. Accordingly, our works introduced the concept of low concentrations of Ca ions, which were first identified as the regulatory substance of muscle contraction, to the vast field of Ca biology including signal transduction.

Recovery Migration to the City of New Orleans after Hurricane Katrina: A Migration Systems Approach

PubMed Central

Fussell, Elizabeth; Curtis, Katherine J.; DeWaard, Jack

2014-01-01

Hurricane Katrina’s effect on the population of the City of New Orleans provides a model of how severe weather events, which are likely to increase in frequency and strength as the climate warms, might affect other large coastal cities. Our research focuses on changes in the migration system – defined as the system of ties between Orleans Parish and all other U.S. counties – between the pre-disaster (1999–2004) and recovery (2007–2009) periods. Using Internal Revenue Service county-to-county migration flow data, we find that in the recovery period Orleans Parish increased the number of migration ties with and received larger migration flows from nearby counties in the Gulf of Mexico coastal region, thereby spatially concentrating and intensifying the in-migration dimension of this predominantly urban system, while the out-migration dimension contracted and had smaller flows. We interpret these changes as the migration system relying on its strongest ties to nearby and less damaged counties to generate recovery in-migration. PMID:24729651

Recovery after high-intensity intermittent exercise in elite soccer players using VEINOPLUS sport technology for blood-flow stimulation.

PubMed

Bieuzen, François; Pournot, Hervé; Roulland, Rémy; Hausswirth, Christophe

2012-01-01

Electric muscle stimulation has been suggested to enhance recovery after exhaustive exercise by inducing an increase in blood flow to the stimulated area. Previous studies have failed to support this hypothesis. We hypothesized that the lack of effect shown in previous studies could be attributed to the technique or device used. To investigate the effectiveness of a recovery intervention using an electric blood-flow stimulator on anaerobic performance and muscle damage in professional soccer players after intermittent, exhaustive exercise. Randomized controlled clinical trial. National Institute of Sport, Expertise, and Performance (INSEP). Twenty-six healthy professional male soccer players. The athletes performed an intermittent fatiguing exercise followed by a 1-hour recovery period, either passive or using an electric blood-flow stimulator (VEINOPLUS). Participants were randomly assigned to a group before the experiment started. Performances during a 30-second all-out exercise test, maximal vertical countermovement jump, and maximal voluntary contraction of the knee extensor muscles were measured at rest, immediately after the exercise, and 1 hour and 24 hours later. Muscle enzymes indicating muscle damage (creatine kinase, lactate dehydrogenase) and hematologic profiles were analyzed before and 1 hour and 24 hours after the intermittent fatigue exercise. The electric-stimulation group had better 30-second all-out performances at 1 hour after exercise (P = .03) in comparison with the passive-recovery group. However, no differences were observed in muscle damage markers, maximal vertical countermovement jump, or maximal voluntary contraction between groups (P > .05). Compared with passive recovery, electric stimulation using this blood-flow stimulator improved anaerobic performance at 1 hour postintervention. No changes in muscle damage markers or maximal voluntary contraction were detected. These responses may be considered beneficial for athletes engaged in sports with successive rounds interspersed with short, passive recovery periods.

48 CFR 227.7204 - Contracts under the Small Business Innovative Research Program.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Business Innovative Research Program. 227.7204 Section 227.7204 Federal Acquisition Regulations System... under the Small Business Innovative Research Program. When contracting under the Small Business Innovative Research Program, follow the procedures at 227-7104. ...

48 CFR 43.205 - Contract clauses.

Code of Federal Regulations, 2011 CFR

2011-10-01

...-engineer or other professional services, and no supplies are to be furnished, the contracting officer shall...-engineer or other professional services, the contracting officer shall use the clause with its Alternate... Accounting, in solicitations and contracts for supply and research and development contracts of significant...

48 CFR 43.205 - Contract clauses.

Code of Federal Regulations, 2010 CFR

2010-10-01

...-engineer or other professional services, and no supplies are to be furnished, the contracting officer shall...-engineer or other professional services, the contracting officer shall use the clause with its Alternate... Accounting, in solicitations and contracts for supply and research and development contracts of significant...

48 CFR 43.205 - Contract clauses.

Code of Federal Regulations, 2013 CFR

2013-10-01

...-engineer or other professional services, and no supplies are to be furnished, the contracting officer shall...-engineer or other professional services, the contracting officer shall use the clause with its Alternate... Accounting, in solicitations and contracts for supply and research and development contracts of significant...

48 CFR 43.205 - Contract clauses.

Code of Federal Regulations, 2014 CFR

2014-10-01

...-engineer or other professional services, and no supplies are to be furnished, the contracting officer shall...-engineer or other professional services, the contracting officer shall use the clause with its Alternate... Accounting, in solicitations and contracts for supply and research and development contracts of significant...

48 CFR 43.205 - Contract clauses.

Code of Federal Regulations, 2012 CFR

2012-10-01

...-engineer or other professional services, and no supplies are to be furnished, the contracting officer shall...-engineer or other professional services, the contracting officer shall use the clause with its Alternate... Accounting, in solicitations and contracts for supply and research and development contracts of significant...

48 CFR 1535.007-70 - Contract clauses.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Contract clauses. 1535.007-70 Section 1535.007-70 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1535.007-70 Contract clauses. The following...

48 CFR 1535.007-70 - Contract clauses.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Contract clauses. 1535.007-70 Section 1535.007-70 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1535.007-70 Contract clauses. The following...

48 CFR 1535.007-70 - Contract clauses.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Contract clauses. 1535.007-70 Section 1535.007-70 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1535.007-70 Contract clauses. The following...

48 CFR 1535.007-70 - Contract clauses.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Contract clauses. 1535.007-70 Section 1535.007-70 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1535.007-70 Contract clauses. The following...

Wind River Watershed Restoration: Annual Report April 2005 - March 2006

USGS Publications Warehouse

Jezorek, Ian G.; Connolly, Patrick J.; Charrier, Jodi; Munz, Carrie

2007-01-01

This report summarizes work completed by U.S. Geological Survey’s Columbia River Research Laboratory (USGS-CRRL) in the Wind River subbasin during the period April 2005 through March 2006 under Bonneville Power Administration (BPA) contract 22095. During this period, we collected temperature, flow, and habitat data to characterize habitat condition and variation within and among tributaries and mainstem sections in the Wind River subbasin. We also conducted electrofishing and snorkeling surveys to determine juvenile salmonid populations within select study areas throughout the subbasin. Portions of this work were completed with additional funding from U.S. Fish and Wildlife Service (USFWS) and the Lower Columbia Fish Enhancement Group (LCFEG).

Level II scour analysis for Bridge 12 (BRAITH00230012) on Town Highway 23, crossing Ayers Brook, Braintree, Vermont

USGS Publications Warehouse

Olson, Scott A.

1996-01-01

D and E. Scour depths and rock rip-rap sizes were computed using the general guidelines described in Hydraulic Engineering Circular 18 (Richardson and others, 1993). Total scour at a highway crossing is comprised of three components: 1) long-term streambed degradation; 2) contraction scour (due to accelerated flow caused by a reduction in flow area at a bridge) and; 3) local scour (caused by accelerated flow around piers and abutments). Total scour is the sum of the three components. Equations are available to compute depths for contraction and local scour and a summary of the results of these computations follows. Contraction scour for all modelled flows ranged from 4.2 to 9.4 ft. The worst-case contraction scour occurred at the incipient-overtopping discharge which was less than the 100-year discharge. Abutment scour ranged from 4.3 to 17.5 ft. The worst-case abutment scour occurred at the 500-year discharge. Additional information on scour depths and depths to armoring are included in the section titled “Scour Results”. Scoured-streambed elevations, based on the calculated scour depths, are presented in tables 1 and 2. A cross-section of the scour computed at the bridge is presented in figure 8. Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1993, p. 48). Usually, computed scour depths are evaluated in combination with other information including (but not limited to) historical performance during flood events, the geomorphic stability assessment, existing scour protection measures, and the results of the hydraulic analyses. Therefore, scour depths adopted by VTAOT may differ from the computed values documented herein.

Muscle blood flow at onset of dynamic exercise in humans.

PubMed

Rådegran, G; Saltin, B

1998-01-01

To evaluate the temporal relationship between blood flow, blood pressure, and muscle contractions, we continuously measured femoral arterial inflow with ultrasound Doppler at onset of passive exercise and voluntary, one-legged, dynamic knee-extensor exercise in humans. Blood velocity and inflow increased (P < 0.006) with the first relaxation of passive and voluntary exercise, whereas the arterial-venous pressure difference was unaltered [P = not significant (NS)]. During steady-state exercise, and with arterial pressure as a superimposed influence, blood velocity was affected by the muscle pump, peaking (P < 0.001) at approximately 2.5 +/- 0.3 m/s as the relaxation coincided with peak systolic arterial blood pressure; blood velocity decreased (P < 0.001) to 44.2 +/- 8.6 and 28.5 +/- 5.5% of peak velocity at the second dicrotic and diastolic blood pressure notches, respectively. Mechanical hindrance occurred (P < 0.001) during the contraction phase at blood pressures less than or equal to that at the second dicrotic notch. The increase in blood flow (Q) was characterized by a one-component (approximately 15% of peak power output), two-component (approximately 40-70% of peak power output), or three-component exponential model (> or = 75% of peak power output), where Q(t) = Qpassive + delta Q1.[1 - e-(t - TD1/tau 1)]+ delta Q2.[1 - e-(t - TD2/tau 2)]+ delta Q3.[1 - e-(t - TD3/tau 3)]; Qpassive, the blood flow during passive leg movement, equals 1.17 +/- 0.11 l/min; TD is the onset latency; tau is the time constant; delta Q is the magnitude of blood flow rise; and subscripts 1-3 refer to the first, second, and third components of the exponential model, respectively. The time to reach 50% of the difference between passive and voluntary asymptotic blood flow was approximately 2.2-8.9 s. The blood flow leveled off after approximately 10-150 s, related to the power outputs. It is concluded that the elevation in blood flow with the first duty cycle(s) is due to muscle mechanical factors, but vasodilators initiate a more potent amplification within the second to fourth contraction.

Mechanical influences on skeletal muscle vascular tone in humans: insight into contraction-induced rapid vasodilatation

PubMed Central

Kirby, Brett S; Carlson, Rick E; Markwald, Rachel R; Voyles, Wyatt F; Dinenno, Frank A

2007-01-01

We tested the hypothesis that mechanical deformation of forearm blood vessels via acute increases in extravascular pressure elicits rapid vasodilatation in humans. In healthy adults, we measured forearm blood flow (Doppler ultrasound) and calculated forearm vascular conductance (FVC) responses to whole forearm compressions and isometric muscle contractions with the arm above heart level. We used several experimental protocols to gain insight into how mechanical factors contribute to contraction-induced rapid vasodilatation. The findings from the present study clearly indicate that acute increases in extravascular pressure (200 mmHg for 2 s) elicit a significant rapid vasodilatation in the human forearm (peak ΔFVC∼155%). Brief, 6 s sustained compressions evoked the greatest vasodilatation (ΔFVC∼260%), whereas the responses to single (2 s) and repeated compressions (five repeated 2 s compressions) were not significantly different (ΔFVC∼155%versus∼115%, respectively). This mechanically induced vasodilatation peaks within 1–2 cardiac cycles, and thus is dissociated from the temporal pattern normally observed in response to brief muscle contractions (∼4–7 cardiac cycles). A non-linear relation was found between graded increases in extravascular pressure and both the immediate and peak rapid vasodilatory response, such that the responses increased sharply from 25 to 100 mmHg, with no significant further dilatation until 300 mmHg (maximal ΔFVC∼185%). This was in contrast to the linear intensity-dependent relation observed with muscle contractions. Our collective findings indicate that mechanical influences contribute largely to the immediate vasodilatation (first cardiac cycle) observed in response to a brief, single contraction. However, it is clear that there are additional mechanisms related to muscle activation that continue to cause and sustain vasodilatation for several more cardiac cycles after contraction. Additionally, the potential contribution of mechanical influences to the total contraction-induced hyperaemia appears greatest for low to moderate intensity single muscle contractions, and this contribution becomes less significant for sustained and repeated contractions. Nevertheless, this mechanically induced vasodilatation could serve as a feedforward mechanism to increase muscle blood flow at the onset of exercise, as well as in response to changes in contraction intensity, prior to alterations in local vasodilating substances that influence vascular tone. PMID:17495044

48 CFR 45.107 - Contract clauses.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Alternate II when a contract for the conduct of basic or applied research at nonprofit institutions of higher education or at nonprofit organizations whose primary purpose is the conduct of scientific research (see 35.014) is contemplated. (b) The contracting officer shall also insert the clause at 52.245-2...

32 CFR 736.2 - Dispositions under contracts.

Code of Federal Regulations, 2010 CFR

2010-07-01

... contract terms and conditions. (c) Transfer to nonprofit education or research institutions of title to equipment purchased with funds available for grants or contracts for the conduct of basic or applied research is authorized by the act of September 6, 1958 (sec. 2, 72 Stat. 1793; 42 U.S.C. 1892) and...

48 CFR 435.010 - Scientific and technical reports.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Scientific and technical reports. 435.010 Section 435.010 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 435.010 Scientific and technical reports. Research and development contracts shal...

48 CFR 435.010 - Scientific and technical reports.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Scientific and technical reports. 435.010 Section 435.010 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 435.010 Scientific and technical reports. Research and development contracts shal...

48 CFR 435.010 - Scientific and technical reports.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Scientific and technical reports. 435.010 Section 435.010 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 435.010 Scientific and technical reports. Research and development contracts shal...

48 CFR 435.010 - Scientific and technical reports.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Scientific and technical reports. 435.010 Section 435.010 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 435.010 Scientific and technical reports. Research and development contracts shal...

New Perils for the Contract Ethnographer.

ERIC Educational Resources Information Center

Fetterman, David M.

1981-01-01

Conditions of contract research may lead some workers to ignore publication rights of colleagues whose reports are of limited circulation. The author presents a case example of how this process occurred with the use of his own work and argues for rigorous ethical standards in the publication of contract research results. (Author/GC)

Cross-talk between cardiac muscle and coronary vasculature.

PubMed

Westerhof, Nico; Boer, Christa; Lamberts, Regis R; Sipkema, Pieter

2006-10-01

The cardiac muscle and the coronary vasculature are in close proximity to each other, and a two-way interaction, called cross-talk, exists. Here we focus on the mechanical aspects of cross-talk including the role of the extracellular matrix. Cardiac muscle affects the coronary vasculature. In diastole, the effect of the cardiac muscle on the coronary vasculature depends on the (changes in) muscle length but appears to be small. In systole, coronary artery inflow is impeded, or even reversed, and venous outflow is augmented. These systolic effects are explained by two mechanisms. The waterfall model and the intramyocardial pump model are based on an intramyocardial pressure, assumed to be proportional to ventricular pressure. They explain the global effects of contraction on coronary flow and the effects of contraction in the layers of the heart wall. The varying elastance model, the muscle shortening and thickening model, and the vascular deformation model are based on direct contact between muscles and vessels. They predict global effects as well as differences on flow in layers and flow heterogeneity due to contraction. The relative contributions of these two mechanisms depend on the wall layer (epi- or endocardial) and type of contraction (isovolumic or shortening). Intramyocardial pressure results from (local) muscle contraction and to what extent the interstitial cavity contracts isovolumically. This explains why small arterioles and venules do not collapse in systole. Coronary vasculature affects the cardiac muscle. In diastole, at physiological ventricular volumes, an increase in coronary perfusion pressure increases ventricular stiffness, but the effect is small. In systole, there are two mechanisms by which coronary perfusion affects cardiac contractility. Increased perfusion pressure increases microvascular volume, thereby opening stretch-activated ion channels, resulting in an increased intracellular Ca2+ transient, which is followed by an increase in Ca2+ sensitivity and higher muscle contractility (Gregg effect). Thickening of the shortening cardiac muscle takes place at the expense of the vascular volume, which causes build-up of intracellular pressure. The intracellular pressure counteracts the tension generated by the contractile apparatus, leading to lower net force. Therefore, cardiac muscle contraction is augmented when vascular emptying is facilitated. During autoregulation, the microvasculature is protected against volume changes, and the Gregg effect is negligible. However, the effect is present in the right ventricle, as well as in pathological conditions with ineffective autoregulation. The beneficial effect of vascular emptying may be reduced in the presence of a stenosis. Thus cardiac contraction affects vascular diameters thereby reducing coronary inflow and enhancing venous outflow. Emptying of the vasculature, however, enhances muscle contraction. The extracellular matrix exerts its effect mainly on cardiac properties rather than on the cross-talk between cardiac muscle and coronary circulation.

Exogenous L-Arginine Attenuates the Effects of Angiotensin II on Renal Hemodynamics and the Pressure Natriuresis-Diuresis Relationship

PubMed Central

Das, Satarupa; Mattson, David L.

2014-01-01

SUMMARY Administration of exogenous L-Arginine (L-Arg) attenuates Angiotensin II (AngII)-mediated hypertension and kidney disease in rats. The present study assessed renal hemodynamics and pressure-diuresis-natriuresis in anesthetized rats infused with vehicle, AngII (20 ng/kg/min, iv) or AngII + L-Arg (300 µg/kg/min, iv). Increasing renal perfusion pressure (RPP) from approximately 100 to 140 mmHg resulted in a 9–10 fold increase in urine flow and sodium excretion rate in control animals. In comparison, AngII infusion significantly reduced renal blood flow (RBF) and glomerular filtration rate (GFR) by 40–42% and blunted the pressure-dependent increase in urine flow and sodium excretion rate by 54–58% at elevated RPP. Supplementation of L-Arg reversed the vasoconstrictor effects of AngII and restored pressure-dependent diuresis to levels not significantly different from control rats. Experiments in isolated aortic rings were performed to assess L-Arg effects on the vasculature. Dose-dependent contraction to AngII (10−10M to 10−7M) was observed with a maximal force equal to 27±3% of the response to 10−5M phenylephrine. Contraction to 10−7M AngII was blunted by 75±3% with 10−4M L-Arg. The influence of L-Arg to blunt AngII mediated contraction was eliminated by endothelial denudation or incubation with nitric oxide synthase inhibitors. Moreover, the addition of 10−3M cationic or neutral amino acids, which compete with L-Arg for cellular uptake, blocked the effect of L-Arg. Anionic amino acids did not influence the effects of L-Arg on AngII-mediated contraction. These studies indicate that L-Arg blunts AngII-mediated vascular contraction by an endothelial- and NOS-dependent mechanism involving cellular uptake of L-Arg. PMID:24472006

Temperature-dependent modulation of regional lymphatic contraction frequency and flow.

PubMed

Solari, Eleonora; Marcozzi, Cristiana; Negrini, Daniela; Moriondo, Andrea

2017-11-01

Lymph drainage and propulsion are sustained by an extrinsic mechanism, based on mechanical forces acting from the surrounding tissues against the wall of lymphatic vessels, and by an intrinsic mechanism attributable to active spontaneous contractions of the lymphatic vessel muscle. Despite being heterogeneous, the mechanisms underlying the generation of spontaneous contractions share a common biochemical nature and are thus modulated by temperature. In this study, we challenged excised tissues from rat diaphragm and hindpaw, endowed with spontaneously contracting lymphatic vessels, to temperatures from 24°C (hindpaw) or 33°C (diaphragmatic vessels) to 40°C while measuring lymphatic contraction frequency ( f c ) and amplitude. Both vessel populations displayed a sigmoidal relationship between f c and temperature, each centered around the average temperature of surrounding tissue (36.7 diaphragmatic and 32.1 hindpaw lymphatics). Although the slope factor of the sigmoidal fit to the f c change of hindpaw vessels was 2.3°C·cycles -1 ·min -1 , a value within the normal range displayed by simple biochemical reactions, the slope factor of the diaphragmatic lymphatics was 0.62°C·cycles -1 ·min -1 , suggesting the added involvement of temperature-sensing mechanisms. Lymph flow calculated as a function of temperature confirmed the relationship observed on f c data alone and showed that none of the two lymphatic vessel populations would be able to adapt to the optimal working temperature of the other tissue district. This poses a novel question whether lymphatic vessels might not adapt their function to accommodate the change if exposed to a surrounding temperature, which is different from their normal condition. NEW & NOTEWORTHY This study demonstrates to what extent lymphatic vessel intrinsic contractility and lymph flow are modulated by temperature and that this modulation is dependent on the body district that the vessels belong to, suggesting a possible functional misbehavior should lymphatic vessels be exposed to a chronically different temperature. Copyright © 2017 the American Physiological Society.

Development of flow in a square mini-channel: Effect of flow oscillation

NASA Astrophysics Data System (ADS)

Lobo, Oswald Jason; Chatterjee, Dhiman

2018-04-01

In this research paper, we present a numerical prediction of steady and fully oscillatory flows in a square mini-channel connected between two plenums. Flow separation occurs at the contraction of the plenum into the channel which causes an asymmetry in the development of flow in the entrance region. The entrance length and recirculation length are found, for both steady and fully oscillatory flows. It is shown that the maximum entrance length decreases with an increase in the oscillating frequency while the maximum recirculation length and recirculation area increase with an increase in oscillating frequency. The phase of a velocity signal is shown to be a strong function of its location. The phase difference between the velocities with respect to the different points along the centerline and those at the middle of the channel show a significant dependence on the driving frequency. There is a significant variation in the phase angles of the velocity signals computed between a point near the wall and that at the centerline. This phase difference decreases along the channel length and does not change beyond the entrance length. This feature can then be used to determine the maximum entrance length, which is otherwise problematic to ascertain in the case of fully oscillatory flows. The entrance length, thus obtained, is compared with that obtained from the velocity profile consideration and shows good similarity. The phase difference between pressure and velocity is also brought out in this work.

Internal aerodynamics of a generic three-dimensional scramjet inlet at Mach 10

NASA Technical Reports Server (NTRS)

Holland, Scott D.

1995-01-01

A combined computational and experimental parametric study of the internal aerodynamics of a generic three-dimensional sidewall compression scramjet inlet configuration at Mach 10 has been performed. The study was designed to demonstrate the utility of computational fluid dynamics as a design tool in hypersonic inlet flow fields, to provide a detailed account of the nature and structure of the internal flow interactions, and to provide a comprehensive surface property and flow field database to determine the effects of contraction ratio, cowl position, and Reynolds number on the performance of a hypersonic scramjet inlet configuration. The work proceeded in several phases: the initial inviscid assessment of the internal shock structure, the preliminary computational parametric study, the coupling of the optimized configuration with the physical limitations of the facility, the wind tunnel blockage assessment, and the computational and experimental parametric study of the final configuration. Good agreement between computation and experimentation was observed in the magnitude and location of the interactions, particularly for weakly interacting flow fields. Large-scale forward separations resulted when the interaction strength was increased by increasing the contraction ratio or decreasing the Reynolds number.

Effect of Phase Lag on Fluid Flow and Particle Dispersion in a Single Human Alveolus

NASA Astrophysics Data System (ADS)

Chhabra, Sudhaker; Prasad, Ajay

2007-11-01

The human lung can be divided into (1) the conducting airways, and (2) the acini. The acini are responsible for gas exchange and consist of alveoli and bronchioles. The acini are useful delivery sites for inhaled therapeutic aerosols. In normal lung function the alveolus expands and contracts in phase with the bronchiole airflow oscillation. Lung diseases such as emphysema compromise the elasticity of the lung. Consequently, the alveolus may not oscillate in-phase with the oscillating bronchiole airflow. We have previously studied flow and particle transport in an alveolus for in-phase flow. The current work focuses on measuring out-of-phase airflow patterns and particle transport in an in-vitro model of a single expanding/contracting human alveolus. The model consists of a transparent, elastic, oscillating alveolus (represented by a 5/6th hemisphere) attached to a rigid circular tube. Realistic tidal breathing conditions were achieved by matching Reynolds and Womersley numbers. Flow patterns were measured using PIV; these velocity maps were subsequently used to calculate particle transport and deposition on the alveolar wall.

Turbulence characteristics of swirling flowfields. Ph.D. Thesis. Final Report

NASA Technical Reports Server (NTRS)

Jackson, T. W.; Lilley, D. G.

1985-01-01

The time mean and turbulence properties of a confined swirling jet using the six orientation, single hot wire technique were obtained. The effect of swirl on a confined, expanding jet is to reduce the size of the corner recirculation zone and generate a central recirculation zone followed by a precessing vortex core. The effect of introducing a contraction nozzle of area ratio four, located two test section diameters downstream of the inlet, is to dramatically reduce the size and shape of the central recirculation zone for the swirling flows considered. The shear stresses are found to increase by an order of magnitude in the region of the contraction nozzle because of large radial gradients of axial velocity. Reduction of the expansion ratio to D/o = 1 causes the time mean flow field to be homogeneous throughout the entire test section with the tangential velocity dominating in the swirling cases. No recirculation zones were observed for these particular flows. Turbulence levels and dissipation rates were found to be low except in the entrance regions and in areas of acceleration in the swirling flow cases.

Five-hole pitot probe time-mean velocity measurements in confined swirling flows

NASA Technical Reports Server (NTRS)

Yoon, H. K.; Lilley, D. G.

1983-01-01

Nonswirling and swirling nonreacting flows in an axisymmetric test section with an expansion ratio D/d = 2, which may be equipped with contraction nozzles of area ratios 2 and 4, are investigated. The effects of a number of geometric parameters on the flow-field are investigated, among them side-wall expansion angles of 90 and 45 deg, swirl vane angles of 0, 38, 45, 60, and 70 deg, and contraction nozzle locations L/D = 1 and 2 (if present). Data are acquired by means of a five-hole pitot probe enabling three time-mean velocity components in the axial, radial, and azimuthal directions to be measured. The velocities are extensively plotted and artistic impressions of recirculation zones are set forth. The presence of a swirler is found to shorten the corner recirculation zone and to generate a central recirculation zone followed by a precessing vortex core. A gradual inlet expansion has the effect of encouraging the flow to remain close to the sidewall and shortening the extent of the corner recirculation zone in all cases investigated.

Skeletal muscle fiber type composition and performance during repeated bouts of maximal, concentric contractions

NASA Technical Reports Server (NTRS)

Colliander, E. B.; Dudley, G. A.; Tesch, P. A.

1988-01-01

Force output and fatigue and recovery patterns were studied during intermittent short-term exercise. 27 men performed three bouts of 30 maximal unilateral knee extensions on 2 different occasions. Blood flow was maintained or occluded during recovery periods (60 s). Blood flow was restricted by inflating a pneumatic cuff placed around the proximal thigh. Muscle biopsies from vastus lateralis were analyzed for identification of fast twitch (FT) and slow twitch (ST) fibers and relative FT area. Peak torque decreased during each bout of exercise and more when blood flow was restricted during recovery. Initial peak torque (IPT) and average peak torque (APT) decreased over the three exercise bouts. This response was 3 fold greater without than with blood flow during recovery. IPT and APT decreased more in individuals with mainly FT fibers than in those with mainly ST fibers. It is suggested that performance during repeated bouts of maximal concentric contractions differs between individuals with different fiber type composition. Specifically, in high intensity, intermittent exercise with emphasis on anaerobic energy release a high FT composition may not necessarily be advantageous for performance.

48 CFR 1835.016-71 - NASA Research Announcements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true NASA Research Announcements... ADMINISTRATION SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1835.016-71 NASA Research Announcements. (a) Scope. An NRA is used to announce research interests in support of NASA's programs, and...

Scour assessments and sediment-transport simulation for selected bridge sites in South Dakota

USGS Publications Warehouse

Niehus, C.A.

1996-01-01

Scour at bridges is a major concern in the design of new bridges and in the evaluation of structural stability of existing bridges. Equations for estimating pier, contraction, and abutment scour have been developed from numerous laboratory studies using sand-bed flumes, but little verification of these scour equations has been done for actual rivers with various bed conditions. This report describes the results of reconnaissance and detailed scour assessments and a sediment-transport simulation for selected bridge sites in South Dakota. Reconnaissance scour assessments were done during 1991 for 32 bridge sites. The reconnaissance assessments for each bridge site included compilation of general and structural data, field inspection to record and measure pertinent scour variables, and evaluation of scour susceptibility using various scour-index forms. Observed pier scour at the 32 sites ranged from 0 to 7 feet, observed contraction scour ranged from 0 to 4 feet, and observed abutment scour ranged from 0 to 10 feet. Thirteen bridge sites having high potential for scour were selected for detailed assessments, which were accomplished during 1992-95. These detailed assessments included prediction of scour depths for 2-, 100-, and 500-year flows using selected published scour equations; measurement of scour during high flows; comparison of measured and predicted scour; and identification of which scour equations best predict actual scour. The medians of predicted pier-scour depth at each of the 13 bridge sites (using 13 scour equations) ranged from 2.4 to 6.8 feet for the 2-year flows and ranged from 3.4 to 13.3 feet for the 500-year flows. The maximum pier scour measured during high flows ranged from 0 to 8.5 feet. Statistical comparison (Spearman rank correlation) of predicted pier-scour depths (using flow data col- lected during scour measurements) indicate that the Laursen, Shen (method b), Colorado State University, and Blench (method b) equations correlate closer with measured scour than do the other prediction equations. The predicted pier-scour depths using the Varzeliotis and Carstens equations have weak statistical rela- tions with measured scour depths. Medians of predicted pier-scour depth from the Shen (method a), Chitale, Bata, and Carstens equations are statistically equal to the median of measured pier-scour depths, based on the Wilcoxon signed-ranks test. The medians of contraction scour depth at each of the 13 bridge sites (using one equation) ranged from -0.1 foot for the 2- year flows to 23.2 feet for the 500-year flows. The maximum contraction scour measured during high flows ranged from 0 to 3.0 feet. The contraction- scour prediction equation substantially overestimated the scour depths in almost all comparisons with the measured scour depths. A significant reason for this discrepancy is due to the wide flood plain (as wide as 5,000 feet) at most of the bridge sites that were investigated. One possible way to reduce this effect for bridge design is to make a decision on what is the effective approach section and thereby limit the size of the bridge flow approach width. The medians of abutment-scour depth at each of the 13 bridge sites (using five equations) ranged from 8.2 to 16.5 feet for the 2-year flows and ranged from 5.7 to 41 feet for the 500-year flows. The maximum abutment scour measured during high flows ranged from 0 to 4.0 feet. The abutment-scour prediction equations also substantially overestimated the scour depths in almost all comparisons with the measured scour depths. The Liu and others (live bed) equation predicted abutment-scour depths substantially lower than the other four abutment-scour equations and closer to the actual measured scour depths. However, this equation at times predicted greater scour depths for 2-year flows than it did for 500-year flows, making its use highly questionable. Again, limiting the bridge flow approach width would produce more reasonable predicted abutment scour.

17 CFR 38.1201 - Additional sources for compliance.

Code of Federal Regulations, 2014 CFR

2014-04-01

... designing a futures contract, the designated contract market should conduct market research so that the contract design meets the risk management needs of prospective users and promotes price discovery of the... and opinions during the contract design process to ensure the contract's term and conditions reflect...

48 CFR 916.405-2 - Cost-plus-award-fee contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., output, be it hardware, research and development, demonstration or services, together with business... CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Incentive Contracts 916.405-2 Cost-plus-award-fee... appropriate) and business management considerations tailored to the needs of the particular situation. In...

48 CFR 35.006 - Contracting methods and contract type.

Code of Federal Regulations, 2011 CFR

2011-10-01

... indicated a high degree of probability that development is feasible and (2) the Government has determined... SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.006 Contracting methods and..., performance objectives, and specifications for the work can be defined will largely determine the type of...

48 CFR 235.072 - Additional contract clauses.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Additional contract clauses. 235.072 Section 235.072 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 235.072 Additional contract clauses. (a) Use the...

48 CFR 235.072 - Additional contract clauses.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Additional contract clauses. 235.072 Section 235.072 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 235.072 Additional contract clauses. (a) Use the...

Hardware for dynamic quantum computing experiments: Part I

NASA Astrophysics Data System (ADS)

Johnson, Blake; Ryan, Colm; Riste, Diego; Donovan, Brian; Ohki, Thomas

Static, pre-defined control sequences routinely achieve high-fidelity operation on superconducting quantum processors. Efforts toward dynamic experiments depending on real-time information have mostly proceeded through hardware duplication and triggers, requiring a combinatorial explosion in the number of channels. We provide a hardware efficient solution to dynamic control with a complete platform of specialized FPGA-based control and readout electronics; these components enable arbitrary control flow, low-latency feedback and/or feedforward, and scale far beyond single-qubit control and measurement. We will introduce the BBN Arbitrary Pulse Sequencer 2 (APS2) control system and the X6 QDSP readout platform. The BBN APS2 features: a sequencer built around implementing short quantum gates, a sequence cache to allow long sequences with branching structures, subroutines for code re-use, and a trigger distribution module to capture and distribute steering information. The X6 QDSP features a single-stage DSP pipeline that combines demodulation with arbitrary integration kernels, and multiple taps to inspect data flow for debugging and calibration. We will show system performance when putting it all together, including a latency budget for feedforward operations. This research was funded by the Office of the Director of National Intelligence (ODNI), Intelligence Advanced Research Projects Activity (IARPA), through the Army Research Office Contract No. W911NF-10-1-0324.

University Research and Development Activities: The Federal Income Tax Consequences of Research Contracts, Research Subsidiaries and Joint Ventures.

ERIC Educational Resources Information Center

Kertz, Consuelo Lauda; Hasson, James K., Jr.

1986-01-01

Features of the federal income tax law applying to income received from commercially funded university-based scientific research and development activities are discussed, including: industry-sponsored research contracts, separately incorporated entities, partnerships and joint ventures, subsidiaries and unrelated income consequences of…

48 CFR 235.015-70 - Special use allowances for research facilities acquired by educational institutions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... research facilities acquired by educational institutions. 235.015-70 Section 235.015-70 Federal Acquisition... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 235.015-70 Special use allowances for research facilities acquired by educational institutions. (a) Definitions. As used in this subsection— (1) Research facility...

48 CFR 32.202-3 - Conducting market research about financing terms.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Conducting market research... 32.202-3 Conducting market research about financing terms. Contract financing may be a subject included in the market research conducted in accordance with part 10. If market research for contract...

48 CFR 32.202-3 - Conducting market research about financing terms.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Conducting market research... 32.202-3 Conducting market research about financing terms. Contract financing may be a subject included in the market research conducted in accordance with part 10. If market research for contract...

48 CFR 3035.017 - Federally Funded Research and Development Centers.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING Scope of Part 3035.017 Federally Funded Research and... use of Federally Funded Research and Development Centers (FFRDCs) in (FAR) 48 CFR 35.017. [71 FR 25771... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Federally Funded Research...

The Effects of Endurance Exercise Training on the Coronary Vascular Responsiveness to Intracoronary Acetylcholine in Swine

DTIC Science & Technology

1993-04-09

systems. The mechanisms of sympathet ic innervation involve a-adrenergic-mediated coronary vascular smooth muscle contraction, and (1- adrenergic-mediated...may cause muscarinic-mediated relaxation or contraction of vascular smooth muscle , depending on the animal species and presence of endothelial...both cardiac muscle layers receive equal flows over a cardiac cycle, regardless of the differences from systo lic compression (Buckberg and Kattus

Influence of cerebral blood vessel movements on the position of perivascular synapses

PubMed Central

DeFelipe, Javier

2017-01-01

Synaptic activity is regulated and limited by blood flow, which is controlled by blood vessel dilation and contraction. Traditionally, the study of neurovascular coupling has mainly focused on energy consumption and oxygen delivery. However, the mechanical changes that blood vessel movements induce in the surrounding tissue have not been considered. We have modeled the mechanical changes that movements of blood vessels cause in neighboring synapses. Our simulations indicate that synaptic densities increase or decrease during vascular dilation and contraction, respectively, near the blood vessel walls. This phenomenon may alter the concentration of neurotransmitters and vasoactive substances in the immediate vicinity of the vessel wall and thus may have an influence on local blood flow. PMID:28199396

Rotor noise due to atmospheric turbulence ingestion. II - Aeroacoustic results

NASA Technical Reports Server (NTRS)

Amiet, R. K.; Simonich, J. C.; Schlinker, R. H.

1986-01-01

A computer program for the prediction of noise due to the turbulence of inflow to a propeller or helicopter rotor is extended to the case of nonisotropic turbulence, on the basis of a combined mean flow contraction model and rapid distortion theory. The mean flow distortion is noted to stretch the turbulence, decreasing the velocities along the principal axis of the stretching. In the case of a principal stretching axis lying close to the rotor axis, the distortion acts to decrease the upwash velocities of the rotor: thereby decreasing the noise from levels associated with isotropic turbulence. Acoustic energies are calculated at observer location for several cases, and compared to the turbulence energy as affected by the contraction.

Assessment of Navy Contract Management Processes

DTIC Science & Technology

2016-02-22

Assessment of Navy Contract Management Processes 22 February 2016 Dr. Rene G. Rendon, Associate Professor Graduate School of Business ...Know) for each survey item in each contract management process area. Acquisition Research Program Graduate School of Business ...management process . Figure 1. U.S. Navy CMMM Maturity Levels Acquisition Research Program Graduate School of Business

13 CFR 126.607 - When must a contracting officer set aside a requirement for qualified HUBZone SBCs?

Code of Federal Regulations, 2012 CFR

2012-01-01

... fair market prices. This requirement does not preclude a contracting officer from setting aside a... will be made at fair market prices. However, after conducting market research, the contracting officer... to support the specific set-aside, including the type and extent of market research conducted. In...

Experimental and mathematical modeling of flow in headboxes

NASA Astrophysics Data System (ADS)

Shariati, Mohammad Reza

The fluid flow patterns in a paper-machine headbox have a strong influence on the quality of the paper produced by the machine. Due to increasing demand for high quality paper there is a need to investigate the details of the fluid flow in the paper machine headbox. The objective of this thesis is to use experimental and computational methods of modeling the flow inside a typical headbox in order to evaluate and understand the mean flow patterns and turbulence created there. In particular, spatial variations of the mean flow and of the turbulence quantities and the turbulence generated secondary flows are studied. In addition to the flow inside the headbox, the flow leaving the slice is also modeled both experimentally and computationally. Comparison of the experimental and numerical results indicated that streamwise mean components of the velocities in the headbox are predicted well by all the turbulence models considered in this study. However, the standard k-epsilon model and the algebraic turbulence models fail to predict the turbulence quantities accurately. Standard k-epsilon-model also fails to predict the direction and magnitude of the secondary flows. Significant improvements in the k-epsilon model predictions were achieved when the turbulence production term was artificially set to zero. This is justified by observations of the turbulent velocities from the experiments and by a consideration of the form of the kinetic energy equation. A better estimation of the Reynolds normal stress distribution and the degree of anisotropy of turbulence was achieved using the Reynolds stress turbulence model. Careful examination of the measured turbulence velocity results shows that after the initial decay of the turbulence in the headbox, there is a short region close to the exit, but inside the headbox, where the turbulent kinetic energy actually increases as a result of the distortion imposed by the contraction. The turbulence energy quickly resumes its decay in the free jet after the headbox. The overall conclusion from this thesis, obtained by comparison of experimental and computational simulations of the flow in a headbox, is that numerical simulations show great promise for predictions of headbox flows. Mean velocities and turbulence characteristics can now be predicted with fair accuracy by careful use of specialized turbulence models. Standard engineering turbulence models, such as the k-epsilon model and its immediate relatives, should not be used to estimate the turbulence quantities essential for predicting pulp fiber dispersion within the contracting region and free jet of a headbox, particularly when the overall contraction ratio is greater than about five. (Abstract shortened by UMI.)

Product Characteristics, Market Conditions and Contract Type: U.S. Department of Defense Use of Fixed-Price and Cost Reimbursement Contracts

DTIC Science & Technology

2015-07-27

R. (2013). Municipalities’ contracting out decisions: An empirical study on motives. Local Government Studies , 39(3), 414-434. Williamson, O...please contact any of the staff listed on the Acquisition Research Program website (www.acquisitionresearch.net). i Acquisition Research Program...market conditions on the use of fixed-price and cost reimbursement contracts by the Department of Defense. When the product is easy to specify

48 CFR 1535.007 - Solicitations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1535.007 Solicitations. (a) Contracting officers... Confidential Business Information, in all solicitations when the contracting officer has determined that EPA may furnish the contractor with confidential business information which EPA had obtained from third...

48 CFR 17.601 - Definition.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 17.601 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Management and Operating Contracts 17.601 Definition. Management..., maintenance, or support, on its behalf, of a Government-owned or -controlled research, development, special...

Impaired contraction of blood clots as a novel prothrombotic mechanism in systemic lupus erythematosus.

PubMed

Le Minh, Giang; Peshkova, Alina D; Andrianova, Izabella A; Sibgatullin, Timur B; Maksudova, Adelia N; Weisel, John W; Litvinov, Rustem I

2018-01-31

The aim of this work was to examine a possible role of clot contraction/retraction in thrombotic complications of systemic lupus erythematosus (SLE). Using a novel automated method, we investigated kinetics of clot contraction in the blood of 51 SLE patients and 60 healthy donors. The functionality of platelets in the SLE patients was assessed using flow cytometry by expression of P-selectin and fibrinogen-binding capacity. The rate and degree of clot contraction were significantly reduced in SLE patients compared with healthy subjects, especially in the patients with higher blood levels of anti-dsDNA antibodies. The reduced platelet contractility correlated with partial refractoriness of platelets isolated from the blood of SLE patients to stimulation induced by the thrombin receptor activating peptide. To test if the anti-dsDNA autoantibodies cause continuous platelet activation, followed by exhaustion and dysfunction of the cells, we added purified exogenous anti-dsDNA autoantibodies from SLE patients to normal blood before clotting. In support of this hypothesis, the antibodies first enhanced clot contraction and then suppressed it in a time-dependent manner. Importantly, a direct correlation of clot contraction parameters with the disease severity suggests that the reduced compactness of intravascular clots and thrombi could be a pathogenic factor in SLE that may exaggerate the impaired blood flow at the site of thrombosis. In conclusion, autoantibodies in SLE can affect platelet contractility, resulting in reduced ability of clots and thrombi to shrink in volume, which increases vessel obstruction and may aggravate the course and outcomes of thrombotic complications in SLE. © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.

Numerical aspects in modeling high Deborah number flow and elastic instability

NASA Astrophysics Data System (ADS)

Kwon, Youngdon

2014-05-01

Investigating highly nonlinear viscoelastic flow in 2D domain, we explore problem as well as property possibly inherent in the streamline upwinding technique (SUPG) and then present various results of elastic instability. The mathematically stable Leonov model written in tensor-logarithmic formulation is employed in the framework of finite element method for spatial discretization of several representative problem domains. For enhancement of computation speed, decoupled integration scheme is applied for shear thinning and Boger-type fluids. From the analysis of 4:1 contraction flow at low and moderate values of the Deborah number (De) the solution with SUPG method does not show noticeable difference from the one by the computation without upwinding. On the other hand, in the flow regime of high De, especially in the state of elastic instability the SUPG significantly distorts the flow field and the result differs considerably from the solution acquired straightforwardly. When the strength of elastic flow and thus the nonlinearity further increase, the computational scheme with upwinding fails to converge and evolutionary solution does not become available any more. All this result suggests that extreme care has to be taken on occasions where upwinding is applied, and one has to first of all prove validity of this algorithm in the case of high nonlinearity. On the contrary, the straightforward computation with no upwinding can efficiently model representative phenomena of elastic instability in such benchmark problems as 4:1 contraction flow, flow over a circular cylinder and flow over asymmetric array of cylinders. Asymmetry of the flow field occurring in the symmetric domain, enhanced spatial and temporal fluctuation of dynamic variables and flow effects caused by extension hardening are properly described in this study.

Research led by participants: a new social contract for a new kind of research

PubMed Central

Vayena, Effy; Brownsword, Roger; Edwards, Sarah Jane; Greshake, Bastian; Kahn, Jeffrey P; Ladher, Navjoyt; O'Connor, Daniel; O'Neill, Onora; Richards, Martin P; Rid, Annette; Sheehan, Mark; Wicks, Paul; Tasioulas, John

2016-01-01

In recent years, there have been prominent calls for a new social contract that accords a more central role to citizens in health research. Typically, this has been understood as citizens and patients having a greater voice and role within the standard research enterprise. Beyond this, however, it is important that the renegotiated contract specifically addresses the oversight of a new, path-breaking approach to health research: participant-led research. In light of the momentum behind participant-led research and its potential to advance health knowledge by challenging and complementing traditional research, it is vital for all stakeholders to work together in securing the conditions that will enable it to flourish. PMID:25825527

Multispectral Imaging Broadens Cellular Analysis

NASA Technical Reports Server (NTRS)

2007-01-01

Amnis Corporation, a Seattle-based biotechnology company, developed ImageStream to produce sensitive fluorescence images of cells in flow. The company responded to an SBIR solicitation from Ames Research Center, and proposed to evaluate several methods of extending the depth of field for its ImageStream system and implement the best as an upgrade to its commercial products. This would allow users to view whole cells at the same time, rather than just one section of each cell. Through Phase I and II SBIR contracts, Ames provided Amnis the funding the company needed to develop this extended functionality. For NASA, the resulting high-speed image flow cytometry process made its way into Medusa, a life-detection instrument built to collect, store, and analyze sample organisms from erupting hydrothermal vents, and has the potential to benefit space flight health monitoring. On the commercial end, Amnis has implemented the process in ImageStream, combining high-resolution microscopy and flow cytometry in a single instrument, giving researchers the power to conduct quantitative analyses of individual cells and cell populations at the same time, in the same experiment. ImageStream is also built for many other applications, including cell signaling and pathway analysis; classification and characterization of peripheral blood mononuclear cell populations; quantitative morphology; apoptosis (cell death) assays; gene expression analysis; analysis of cell conjugates; molecular distribution; and receptor mapping and distribution.

Dynamics of polymers in elongational flow studied by the neutron spin-echo technique

NASA Astrophysics Data System (ADS)

Rheinstädter, Maikel C.; Sattler, Rainer; Häußler, Wolfgang; Wagner, Christian

2010-09-01

The nanoscale fluctuation dynamics of semidilute high molecular weight polymer solutions of polyethylenoxide (PEO) in D 2O under non-equilibrium flow conditions were studied by the neutron spin-echo technique. The sample cell was in contraction flow geometry and provided a pressure driven flow with a high elongational component that stretched the polymers most efficiently. Neutron scattering experiments in dilute polymer solutions are challenging because of the low polymer concentration and corresponding small quasi-elastic signals. A relaxation process with relaxation times of about 10 ps was observed, which shows anisotropic dynamics with applied flow.

Positron emission tomography detects greater blood flow and less blood flow heterogeneity in the exercising skeletal muscles of old compared with young men during fatiguing contractions

PubMed Central

Rudroff, Thorsten; Weissman, Jessica A; Bucci, Marco; Seppänen, Marko; Kaskinoro, Kimmo; Heinonen, Ilkka; Kalliokoski, Kari K

2014-01-01

The purpose of this study was to investigate blood flow and its heterogeneity within and among the knee muscles in five young (26 ± 6 years) and five old (77 ± 6 years) healthy men with similar levels of physical activity while they performed two types of submaximal fatiguing isometric contraction that required either force or position control. Positron emission tomography (PET) and [15O]-H2O were used to determine blood flow at 2 min (beginning) and 12 min (end) after the start of the tasks. Young and old men had similar maximal forces and endurance times for the fatiguing tasks. Although muscle volumes were lower in the older subjects, total muscle blood flow was similar in both groups (young men: 25.8 ± 12.6 ml min−1; old men: 25.1 ± 15.4 ml min−1; age main effect, P = 0.77) as blood flow per unit mass of muscle in the exercising knee extensors was greater in the older (12.5 ± 6.2 ml min−1 (100 g)−1) than the younger (8.6 ± 3.6 ml min−1 (100 g)−1) men (age main effect, P = 0.001). Further, blood flow heterogeneity in the exercising knee extensors was significantly lower in the older (56 ± 27%) than the younger (67 ± 34%) men. Together, these data show that although skeletal muscles are smaller in older subjects, based on the intact neural drive to the muscle and the greater, less heterogeneous blood flow per gram of muscle, old fit muscle achieves adequate exercise hyperaemia. Key points The results of previous studies that attempted to demonstrate the effects of ageing on skeletal muscle blood flow are controversial because these studies used indirect assessments of skeletal muscle blood flow obtained via whole limb blood flow measurements that provide no information on the distribution of blood flow within particular muscles. We used positron emission tomography to measure blood flow per gram of muscle in old and young men with similar levels of physical activity. Resting muscle blood flow was similar in both groups and exercising muscle blood flow was greater and less heterogeneous in the older men. Old and young men achieved similar maximal voluntary contraction forces and endurance times during two types of fatiguing isometric task. These findings indicate that physically active old men have intact neural drive to the muscle and achieve adequate exercise hyperaemia despite the age-induced decrease in their muscle volume. PMID:24247981

Clot contraction: compression of erythrocytes into tightly packed polyhedra and redistribution of platelets and fibrin

PubMed Central

Cines, Douglas B.; Lebedeva, Tatiana; Nagaswami, Chandrasekaran; Hayes, Vincent; Massefski, Walter; Litvinov, Rustem I.; Rauova, Lubica; Lowery, Thomas J.

2014-01-01

Contraction of blood clots is necessary for hemostasis and wound healing and to restore flow past obstructive thrombi, but little is known about the structure of contracted clots or the role of erythrocytes in contraction. We found that contracted blood clots develop a remarkable structure, with a meshwork of fibrin and platelet aggregates on the exterior of the clot and a close-packed, tessellated array of compressed polyhedral erythrocytes within. The same results were obtained after initiation of clotting with various activators and also with clots from reconstituted human blood and mouse blood. Such close-packed arrays of polyhedral erythrocytes, or polyhedrocytes, were also observed in human arterial thrombi taken from patients. The mechanical nature of this shape change was confirmed by polyhedrocyte formation from the forces of centrifugation of blood without clotting. Platelets (with their cytoskeletal motility proteins) and fibrin(ogen) (as the substrate bridging platelets for contraction) are required to generate the forces necessary to segregate platelets/fibrin from erythrocytes and to compress erythrocytes into a tightly packed array. These results demonstrate how contracted clots form an impermeable barrier important for hemostasis and wound healing and help explain how fibrinolysis is greatly retarded as clots contract. PMID:24335500

Contraction design for small low-speed wind tunnels

NASA Technical Reports Server (NTRS)

Bell, James H.; Mehta, Rabindra D.

1988-01-01

An iterative design procedure was developed for two- or three-dimensional contractions installed on small, low-speed wind tunnels. The procedure consists of first computing the potential flow field and hence the pressure distributions along the walls of a contraction of given size and shape using a three-dimensional numerical panel method. The pressure or velocity distributions are then fed into two-dimensional boundary layer codes to predict the behavior of the boundary layers along the walls. For small, low-speed contractions it is shown that the assumption of a laminar boundary layer originating from stagnation conditions at the contraction entry and remaining laminar throughout passage through the successful designs if justified. This hypothesis was confirmed by comparing the predicted boundary layer data at the contraction exit with measured data in existing wind tunnels. The measured boundary layer momentum thicknesses at the exit of four existing contractions, two of which were 3-D, were found to lie within 10 percent of the predicted values, with the predicted values generally lower. From the contraction wall shapes investigated, the one based on a fifth-order polynomial was selected for installation on a newly designed mixing layer wind tunnel.

Contraction design for small low-speed wind tunnels

NASA Technical Reports Server (NTRS)

Bell, James H.; Mehta, Rabindra D.

1988-01-01

An iterative design procedure was developed for 2- or 3-dimensional contractions installed on small, low speed wind tunnels. The procedure consists of first computing the potential flow field and hence the pressure distributions along the walls of a contraction of given size and shape using a 3-dimensional numerical panel method. The pressure or velocity distributions are then fed into 2-dimensional boundary layer codes to predict the behavior of the boundary layers along the walls. For small, low speed contractions, it is shown that the assumption of a laminar boundary layer originating from stagnation conditions at the contraction entry and remaining laminar throughout passage through the successful designs is justified. This hypothesis was confirmed by comparing the predicted boundary layer data at the contraction exit with measured data in existing wind tunnels. The measured boundary layer momentum thicknesses at the exit of four existing contractions, two of which were 3-D, were found to lie within 10 percent of the predicted values, with the predicted values generally lower. From the contraction wall shapes investigated, the one based on a 5th order polynomial was selected for newly designed mixing wind tunnel installation.

A Female Urinary Diversion Device for Military Women in the Deployed Environment

DTIC Science & Technology

2016-10-27

9. SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S) TriService Nursing Research TSNRP Program, 4301 Jones...reported there were many opportunities for a FUDD due to unsanitary and challenging conditions. Implications for Military Nursing : This research...Contract PoP: 6/1/2011 - 5/31/2016 Customer: TRISERVICE NURSING RESEARCH PROGRAM Customer Contract ID: HU0001 -11-1-TS02 Contract Manager: Robinson

48 CFR 1335.001 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1335.001 Definitions. Human subject means a living individual... includes communication or interpersonal contact between investigator and subject. “Private information...) in order for obtaining the information to constitute research involving human subjects. Research...

75 FR 990 - HHS Intent To Publish Grant and Contract Solicitations for Comparative Effectiveness Research...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-07

... Publish Grant and Contract Solicitations for Comparative Effectiveness Research (CER) Projects With Funds... input, the Comparative Effectiveness Research- Coordination Implementation Team, the Federal Coordinating Council for Comparative Effectiveness Research (FCC), and the Institute of Medicine Report on CER...

48 CFR 35.004 - Publicizing requirements and expanding research and development sources.

Code of Federal Regulations, 2011 CFR

2011-10-01

... and expanding research and development sources. 35.004 Section 35.004 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.004 Publicizing requirements and expanding research and development sources. (a) In order to...

48 CFR 35.009 - Subcontracting research and development effort.

Code of Federal Regulations, 2010 CFR

2010-10-01

... ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.009 Subcontracting research and development effort. Since the selection of R&D contractors is substantially based on... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Subcontracting research...

Lateral, Vertical, and Longitudinal Source Area Connectivity Drive Runoff and Carbon Export Across Watershed Scales

NASA Astrophysics Data System (ADS)

Zimmer, Margaret A.; McGlynn, Brian L.

2018-03-01

Watersheds are three-dimensional hydrologic systems where the longitudinal expansion/contraction of stream networks, vertical connection/disconnection between shallow and deep groundwater systems, and lateral connectivity of these water sources to streams mediate runoff production and nutrient export. The connectivity of runoff source areas during both baseflow and stormflow conditions and their combined influence on biogeochemical fluxes remain poorly understood. Here we focused on a set of 3.3 and 48.4 ha nested watersheds (North Carolina, USA). These watersheds comprise ephemeral and intermittent runoff-producing headwaters and perennial runoff-producing lowlands. Within these landscape elements, we characterized the timing and magnitude of precipitation, runoff, and runoff-generating flow paths. The active surface drainage network (ASDN) reflected connectivity to, and contributions from, source areas that differed under baseflow and stormflow conditions. The baseflow-associated ASDN expanded and contracted seasonally, driven by the rise and fall of the seasonal water table. Superimposed on this were event-activated source area contributions driven by connectivity to surficial and shallow subsurface flow paths. Frequently activated shallow flow paths also caused increased in-stream dissolved organic carbon (DOC) concentrations with increases in runoff across both watershed scales. The spread and variability within this DOC-runoff relationship was driven by a seasonal depletion of DOC from continual shallow subsurface flow path activation and subsequent replenishment from autumn litterfall. Our findings suggest that hydrobiogeochemical signals at larger watershed outlets can be driven by the expansion, contraction, and connection of lateral, longitudinal, and vertical source areas with distinct runoff generation processes.

Level II scour analysis for Bridge 34 (RANDTH00660034) on Town Highway 66, crossing Second Branch White River, Randolph, Vermont

USGS Publications Warehouse

Olson, Scott A.; Ayotte, Joseph D.

1996-01-01

Total scour at a highway crossing is comprised of three components: 1) long-term aggradation or degradation; 2) contraction scour (due to reduction in flow area caused by a bridge) and; 3) local scour (caused by accelerated flow around piers and abutments). Total scour is the sum of the three components. Equations are available to compute scour depths for contraction and local scour and a summary of the results follows. Contraction scour for all modelled flows ranged from 6.3 ft to 7.8 ft and the worst-case contraction scour occurred at the 100-year discharge. Abutment scour ranged from 7.9 ft to 20.3 ft and the worst-case abutment scour occurred at the 500-year discharge. Scour depths and depths to armoring are summarized on p. 14 in the section titled “Scour Results”. Scour elevations, based on the calculated depths are presented in tables 1 and 2; a graph of the scour elevations is presented in figure 8 Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. For all scour presented in this report, “the scour depths adopted [by VTAOT] may differ from the equation values based on engineering judgement” (Richardson and others, 1993, p. 21, 27). It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1993, p. 48). Many factors, including historical performance during flood events, the geomorphic assessment, and the results of the hydraulic analyses, must be considered to properly assess the validity of abutment scour results.

Level II scour analysis for Bridge 39 (RANDTH00730039) on Town Highway 73, crossing the Second Branch White River, Randolph, Vermont

USGS Publications Warehouse

Song, Donald L.; Ivanoff, Michael A.

1996-01-01

Total scour at a highway crossing is comprised of three components: 1) long-term aggradation or degradation; 2) contraction scour (due to reduction in flow area caused by a bridge) and; 3) local scour (caused by accelerated flow around piers and abutments). Total scour is the sum of the three components. Equations are available to compute scour depths for contraction and local scour and a summary of the results follows. Contraction scour for all modelled flows ranged from 1.9 ft to 4.6 ft and the worst-case contraction scour occurred at the incipient overtopping discharge. Abutment scour ranged from 4.0 ft to 22.5 ft and the worst-case abutment scour occurred at the 500-year discharge. Scour depths and depths to armoring are summarized on p. 14 in the section titled “Scour Results”. Scour elevations, based on the calculated depths are presented in tables 1 and 2; a graph of the scour elevations is presented in figure 8 Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. For all scour presented in this report, “the scour depths adopted [by VTAOT] may differ from the equation values based on engineering judgement” (Richardson and others, 1993, p. 21, 27). It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1993, p. 48). Many factors, including historical performance during flood events, the geomorphic assessment, and the results of the hydraulic analyses, must be considered to properly assess the validity of abutment scour results.

Level II scour analysis for Bridge 3 (BRIDTH000100003) on Town Highway 1, crossing Dailey Hollow Branch, Bridgewater, Vermont

USGS Publications Warehouse

Olson, Scott A.; Song, Donald L.

1996-01-01

Total scour at a highway crossing is comprised of three components: 1) long-term aggradation or degradation; 2) contraction scour (due to reduction in flow area caused by a bridge) and; 3) local scour (caused by accelerated flow around piers and abutments). Total scour is the sum of the three components. Equations are available to compute scour depths for contraction and local scour and a summary of the results follows. Contraction scour for all modelled flows ranged from 0.6 ft to 1.3 ft and the worst-case contraction scour occurred at the 500-year discharge. Abutment scour ranged from 6.7 ft to 12.2 ft and the worst-case abutment scour occurred at the 500-year discharge. Scour depths and depths to armoring are summarized on p. 14 in the section titled “Scour Results”. Scour elevations, based on the calculated depths are presented in tables 1 and 2; a graph of the scour elevations is presented in figure 8 Scour depths were calculated assuming an infinite depth of erosive material and a homogeneous particle-size distribution. For all scour presented in this report, “the scour depths adopted [by VTAOT] may differ from the equation values based on engineering judgement” (Richardson and others, 1993, p. 21, 27). It is generally accepted that the Froehlich equation (abutment scour) gives “excessively conservative estimates of scour depths” (Richardson and others, 1993, p. 48). Many factors, including historical performance during flood events, the geomorphic assessment, and the results of the hydraulic analyses, must be considered to properly assess the validity of abutment scour results.

Turbulent Boundary Layer Flow over Superhydrophobic Surfaces

DTIC Science & Technology

2013-05-10

DATES COVERED (From - To) 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER Turbulent Boundary Layer Flow over Superhydrophobic ...modified surfaces. This study encompassed the testing of four different surfaces: 1) Teflon SLIP, 2) Aluminum SLIP, 3) Honeycomb Superhydrophobic and 4...Polydimethylsiloxane elastomer (PDMSe) Superhydrophobic . Each of these surfaces uses specific geometrical surface features to modify the original

Flow monitoring and control system for injection wells

DOEpatents

Corey, J.C.

1991-01-01

The present invention relates to a system for monitoring and controlling the rate of fluid flow from an injection well used for in-situ remediation of contaminated groundwater. The United States Government has rights in this invention pursuant to Contract No. DE-AC09-89SR18035 between the US Department of Energy and Westinghouse Savannah River Company.

Principles of Social Justice in Educational Research: The Case of Contract Research.

ERIC Educational Resources Information Center

Griffiths, Morwenna

1998-01-01

Delineates small-scale contract-research principles predicated on an understanding of social justice and of research purposes, epistemological issues, and possibilities for ethical and political action. Principles embrace improvement, knowledge and learning, changed belief systems, collaboration and consultation, openness to other communities,…

Critical Life Prediction Research on Boron-Enhanced Ti-6A1-4V

DTIC Science & Technology

2007-05-01

2.4 High Modulus Ti-6Al-2Fe-0.1Si-0.6B “T” Extrusions for HSCT program. Ref. Government Contract No. NASI -20220: High Speed Research-Airframe...0.1Si-0.6B “T” Extrusions for HSCT program. Ref. Government Contract No. NASI -20220: High Speed Research-Airframe Technology report. with the focus...baseline Ti-6Al-4V (Government Contract No. NASI -20220, High Speed Research-Airframe Technology Report, 1997: 3-5, 14, 26). 1 in 3 in 16 In

Collaborative Research: The Alphabetic Braille and Contracted Braille Study as an Example of Collaborative Research

ERIC Educational Resources Information Center

Wormsley, Diane P.; Emerson, Robert Wall; Erin, Jane

2011-01-01

This article examines the Alphabetic Braille Contracted Braille Study in relation to the dimensions of collaborative research: extent, intensity, substance, heterogeneity, velocity, formality, and productivity. It also discusses the dimensions of financing research and researchers' attitudes. The overall consensus is that the study would not have…

Studies of aerodynamic technology for VSTOL fighter/attack aircraft

NASA Technical Reports Server (NTRS)

Nelms, W. P.

1978-01-01

The paper summarizes several studies to develop aerodynamic technology for high performance VSTOL aircraft anticipated after 1990. A contracted study jointly sponsored by NASA-Ames and David Taylor Naval Ship Research and Development Center is emphasized. Four contractors analyzed two vertical-attitude and three horizontal-attitude takeoff and landing concepts with gross weights ranging from about 10433 kg (23,000 lb) to 17236 kg (38,000 lb). The aircraft have supersonic capability, high maneuver performance (sustained load factor 6.2 at Mach 0.6, 3048 m (10,000 ft)) and a 4536 kg (10,000-lb) STO overload capability. The contractors have estimated the aerodynamics and identified aerodynamic uncertainties associated with their concept. Example uncertainties relate to propulsion-induced flows, canard-wing interactions, and top inlets. Wind-tunnel research programs were proposed to investigate these uncertainties.

Streambed scour evaluations and conditions at selected bridge sites in Alaska, 2012

USGS Publications Warehouse

Beebee, Robin A.; Schauer, Paul V.

2015-11-19

Vertical contraction and pressure flow occurred during 1 percent or smaller annual exceedance probability floods at five sites, including three aggradation sites. Contraction scour exceeded 5 feet at two sites, and total scour at piers (pier scour plus contraction scour) exceeded 5 feet at two sites. Debris accumulation increased calculated pier scour at six sites by an average of 1.2 feet. Total scour at abutments including contraction scour exceeded 5 feet at seven sites. Scour estimates seemed excessive at aggradation sites where upstream sediment supply controls scour and deposition processes, at cohesive soil sites where conservative assumptions were made for soil strength and flood duration, and for abutment scour at sites where failure of the embankment and attendant channel widening would reduce scour.

48 CFR 212.7002-1 - Contracts under the program.

Code of Federal Regulations, 2010 CFR

2010-10-01

... for Transition to Follow-On Contracting After Use of Other Transaction Authority 212.7002-1 Contracts under the program. (a) The contracting officer may use FAR part 12 procedures to award a contract for an... process begun as a prototype project under an other transaction agreement or as a research project carried...

Marketing and commercialization of computational research services.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Toevs, J. W.

Physical and computational scientists and mathematicians in Russia's nuclear cities are turning their work toward generating profits from Western markets. Successful ventures require an understanding of the marketing of contract research as well as Western expectations regarding contract execution, quality, and performance. This paper will address fundamentals in business structure, marketing, and contract performance for organizations engaging in the marketing and commercialization of research services. Considerable emphasis will be placed on developing adequate communication within the organization.

The drag and lift of different non-spherical particles from low to high Re

NASA Astrophysics Data System (ADS)

Sanjeevi, Sathish K. P.; Padding, Johan

2017-11-01

The present work investigates a simplified drag and lift model that can be used for different non-spherical particles. The flow around different non-spherical particles is studied using a multi-relaxation-time lattice Boltzmann method. We compute the mean drag coefficient CD , ϕ at different incident angles ϕ for a wide range of Reynolds numbers (Re). We show that the sine-squared drag law CD , ϕ =CD , ϕ =0° +(CD , ϕ =90° -CD , ϕ =0°) sin2 ϕ holds up to large Reynolds numbers Re = 2000 . The sine-squared dependence of CD occurs at Stokes flow (very low Re) due to linearity of the flow fields. We explore the physical origin behind the sine-squared law at high Re , and reveal that surprisingly, this does not occur due to linearity of flow fields. Instead, it occurs due to an interesting pattern of pressure distribution contributing to the drag, at higher Re , for different incident angles. Similarly, we find that the equivalent theoretical equation of lift coefficient CL can provide a decent approximation, even at high Re , for elongated particles. Such a drag and lift law valid at high Re is very much useful for Euler-Lagrangian fluidization simulations of the non-spherical particles. European Research Council (ERC) consolidator Grant scheme, Contract No. 615096 (NonSphereFlow).

Integration of three echelon supply chain (supplier-manufacturer-distributor-drop shipper) with permissible delay in payment and penalty contract

NASA Astrophysics Data System (ADS)

Ibrahim, M. F.; Suparno

2018-04-01

Supply Chain Management (SCM) has to be considered in the company in order to improve the sustainability and competitiveness. SCM executed to integrating any companies on the supply chain in a way of coordinating the flow of goods, information, and financial. Permissible delay in payment is one of the coordination ways with allowing the costumers delay the payments to a vendor in some certain periods without any interest charges. In the supply chain system, drop-shipping player already familiar in this era. In drop-shipping internet retailing, the supplier will hold supplies and also carry out physical distribution service on behalf of drop-shipper. Drop-shipper will just focus on selling, on the other hand, their supplier will be responsible for the physical process. Generally, drop-shipper have information of the customer demands better than the distributor. But, it is also unrare when the drop-shipper send the estimation of demands which bigger than their own estimation in order to maximize their own interest, so they hope supplies of the distributor will always enough to accommodate their demands. Contributions in this research will be focused on integration of three echelons supply chain, which are the supplier, manufacturer, distributor, and drop-shipper. With considering delay in payment on first and second echelons, and also the contract penalty on third echelon. The problem on this research will be modeled in some kind of cases which can represent the problem of real supply chain system. Sensitivity analysis will be done on certain significant variables toward the changes of total supply chain cost. Coordination with delay in payment success to integrate supply chain. Contract penalty plan success to maintain the profit of distributor and drop-shipper.

Optical Diagnostics for Flow Control on Small Wings

DTIC Science & Technology

2016-07-13

AFRL-AFOSR-VA-TR-2016-0250 Optical diagnostics for flow control on small wings GEOFF SPEDDING UNIVERSITY OF SOUTHERN CALIFORNIA LOS ANGELES...Control on Small Wings 5a. CONTRACT NUMBER 5b. GRANT NUMBER FA9550-15-1-0255 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Geoffrey R Spedding 5d. PROJECT...Nd:YAG laser has been purchased, installed, and heavily-used in essential work. Two most recent investigations concern the flow over a complex wing

Thermal and Mechanical Non-Equilibrium Effects on Turbulent Flows: Fundamental Studies of Energy Exchanges Through Direct Numerical Simulations, Molecular Simulations and Experiments

DTIC Science & Technology

2016-02-26

AFRL-AFOSR-VA-TR-2016-0104 Thermal and mechanical non-equilibrium effects on turbulent flows:fundamental studies of energy exchanges through direct...flows: fundamental studies of energy exchanges through direct numerical simulations, molecular simulations and experiments 5a.  CONTRACT NUMBER 5b...AVAILABILITY STATEMENT A DISTRIBUTION UNLIMITED: PB Public Release 13. SUPPLEMENTARY NOTES 14. ABSTRACT Utilizing internal energy exchange for intelligent

Analysis of Peristaltic Waves & their Role in Migrating Physarum Plasmodia

NASA Astrophysics Data System (ADS)

Lewis, Owen; Guy, Robert

2017-11-01

The true slime mold Physarum polycephalum exhibits a vast array of sophisticated manipulations of its intracellular cytoplasm. Growing microplasmodia of physarum have been observed to adopt an elongated tadpole shape, then contract in a rhythmic, traveling wave pattern that resembles peristaltic pumping. This contraction drives a fast flow of non-gelated cytoplasm along the cell longitudinal axis. It has been hypothesized that this flow of cytoplasm is a driving factor in generating motility of the plasmodium. In this work, we use two different mathematical models to investigate how peristaltic pumping within physarum may be used to drive cellular motility. We compare the relative phase of flow and deformation waves predicted by both models to similar phase data collected from in vivo experiments using physarum plasmodia. Both models suggest that a mechanical asymmetry in the cell is required to reproduce the experimental observations. Such a mechanical asymmetry is also shown to increase the potential for cellular migration, as measured by both stress generation and migration velocity.

Oesophageal dysfunction in patients with primary Sjögren's syndrome.

PubMed Central

Tsianos, E B; Chiras, C D; Drosos, A A; Moutsopoulos, H M

1985-01-01

Oesophageal motility was studied in 22 patients with primary Sjögren's syndrome and 20 normal volunteers. Oesophageal dysfunction was detected in eight of the 22 patients (36.4%) with primary Sjögren's syndrome. No abnormalities were detected in the normal subjects. Individual analysis of the oesophageal motility studies showed different patterns of oesophageal dysfunction; aperistalsis (three patients), triphasic tertiary contractions (two patients), frequent non-peristaltic contractions (two patients), and low contractions (one patient). These oesophageal abnormalities did not correlate with the parotid flow rate, the degree of inflammatory infiltrate of the minor salivary glands, the extraglandular manifestations, or the presence of autoantibodies. Images PMID:4037887

Free radicals in tetanic activity of isolated skeletal muscle.

PubMed

Koren, A; Sauber, C; Sentjurc, M; Schara, M

1983-01-01

1. The concentration of the free radicals in muscle tissue mitochondria changes with the phase of muscle contraction. 2. Potassium cyanide (KCN) influences the shape of the isotonic tetani mechanograms; the contraction is still strong and qualitatively comparable in amplitude to untreated controls. 3. On the other hand, the correlation between the free radical concentration and muscle contraction is lost. 4. The free radical concentration in isolated mitochondria is influenced by KCN and potassium ferricyanide. 5. The free radical concentration changes due to the electron flow in the respiratory chain. 6. Inhibition of the respiratory phosphorylation by KCN could affect the free radical level.

Federal Research and Development Contract Trends and the Supporting Industrial Base, 2000-2014

DTIC Science & Technology

2016-04-30

Homeland Security, and government-wide services contracting trends; sourcing policy and cost estimation methodologies; and recent U.S. Army modernization ...been fears that the sharp downturn in federal contract obligations would disproportionately impact the R&D contracting portfolios within individual...329 - contracting portfolios , and the industrial base that supports those efforts, within each R&D contracting agency. The main finding of this

48 CFR 216.104-70 - Research and development.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Research and development... Contract Types § 216.104-70 Research and development. Follow the procedures at PGI 216.104-70 for selecting the appropriate research and development contract type. [71 FR 39007, July 11, 2006] ...

48 CFR 2052.235-70 - Publication of research results.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Publication of research....235-70 Publication of research results. As prescribed in 2035.70(a)(1), the contracting officer shall insert the following clause in applicable solicitations and contracts for research and development by...

41 CFR 101-29.220 - Market research and analysis.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 41 Public Contracts and Property Management 2 2012-07-01 2012-07-01 false Market research and analysis. 101-29.220 Section 101-29.220 Public Contracts and Property Management Federal Property... PRODUCT DESCRIPTIONS 29.2-Definitions § 101-29.220 Market research and analysis. Market research and...

48 CFR 216.104-70 - Research and development.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Research and development... Contract Types § 216.104-70 Research and development. Follow the procedures at PGI 216.104-70 for selecting the appropriate research and development contract type. [71 FR 39007, July 11, 2006] ...

41 CFR 101-29.220 - Market research and analysis.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Market research and analysis. 101-29.220 Section 101-29.220 Public Contracts and Property Management Federal Property... PRODUCT DESCRIPTIONS 29.2-Definitions § 101-29.220 Market research and analysis. Market research and...

41 CFR 101-29.220 - Market research and analysis.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 41 Public Contracts and Property Management 2 2014-07-01 2012-07-01 true Market research and analysis. 101-29.220 Section 101-29.220 Public Contracts and Property Management Federal Property... PRODUCT DESCRIPTIONS 29.2-Definitions § 101-29.220 Market research and analysis. Market research and...

48 CFR 216.104-70 - Research and development.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Research and development... Contract Types § 216.104-70 Research and development. Follow the procedures at PGI 216.104-70 for selecting the appropriate research and development contract type. [71 FR 39007, July 11, 2006] ...

48 CFR 227.7204 - Contracts under the Small Business Innovation Research Program.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Business Innovation Research Program. 227.7204 Section 227.7204 Federal Acquisition Regulations System... under the Small Business Innovation Research Program. When contracting under the Small Business Innovation Research Program, follow the procedures at 227-7104. [56 FR 36389, July 31, 1991, as amended at 76...

48 CFR 227.7204 - Contracts under the Small Business Innovation Research Program.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Business Innovation Research Program. 227.7204 Section 227.7204 Federal Acquisition Regulations System... under the Small Business Innovation Research Program. When contracting under the Small Business Innovation Research Program, follow the procedures at 227-7104. [56 FR 36389, July 31, 1991, as amended at 76...

48 CFR 227.7204 - Contracts under the Small Business Innovation Research Program.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Business Innovation Research Program. 227.7204 Section 227.7204 Federal Acquisition Regulations System... under the Small Business Innovation Research Program. When contracting under the Small Business Innovation Research Program, follow the procedures at 227-7104. [56 FR 36389, July 31, 1991, as amended at 76...

48 CFR 227.7204 - Contracts under the Small Business Innovation Research Program.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Business Innovation Research Program. 227.7204 Section 227.7204 Federal Acquisition Regulations System... under the Small Business Innovation Research Program. When contracting under the Small Business Innovation Research Program, follow the procedures at 227-7104. [56 FR 36389, July 31, 1991, as amended at 76...

An in situ optical imaging system for measuring lipid uptake, vessel contraction, and lymph flow in small animal lymphatic vessels

NASA Astrophysics Data System (ADS)

Kassis, Timothy; Weiler, Michael J.; Dixon, J. Brandon

2012-03-01

All dietary lipids are transported to venous circulation through the lymphatic system, yet the underlying mechanisms that regulate this process remain unclear. Understanding how the lymphatics functionally respond to changes in lipid load is important in the diagnosis and treatment of lipid and lymphatic related diseases such as obesity, hypercholesterolemia, and lymphedema. Therefore, we sought to develop an in situ imaging system to quantify and correlate lymphatic function as it relates to lipid transport. A custom-built optical set-up provides us with the capability of dual-channel imaging of both high-speed bright-field video and fluorescence simultaneously. This is achieved by dividing the light path into two optical bands. Utilizing high-speed and back-illuminated CCD cameras and post-acquisition image processing algorithms, we have the potential quantify correlations between vessel contraction, lymph flow and lipid concentration of mesenteric lymphatic vessels in situ. Local flow velocity is measured through lymphocyte tracking, vessel contraction through measurements of the vessel walls and lipid uptake through fluorescence intensity tracking of a fluorescent long chain fatty acid analogue, Bodipy FL C16. This system will prove to be an invaluable tool for both scientists studying lymphatic function in health and disease, and those investigating strategies for targeting the lymphatic system with orally delivered drugs.

48 CFR 1335.001 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1335.001 Definitions. Human subject means a living individual...” includes information about behavior that occurs in a context in which an individual can reasonably expect...) in order for obtaining the information to constitute research involving human subjects. Research...

48 CFR 1335.001 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1335.001 Definitions. Human subject means a living individual...” includes information about behavior that occurs in a context in which an individual can reasonably expect...) in order for obtaining the information to constitute research involving human subjects. Research...

48 CFR 1335.001 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1335.001 Definitions. Human subject means a living individual...” includes information about behavior that occurs in a context in which an individual can reasonably expect...) in order for obtaining the information to constitute research involving human subjects. Research...

48 CFR 1335.001 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1335.001 Definitions. Human subject means a living individual...” includes information about behavior that occurs in a context in which an individual can reasonably expect...) in order for obtaining the information to constitute research involving human subjects. Research...

Research and development studies for MHD/coal power flow train components. Part II. Diagnostics and instrumentation MHD channel combutor. Progres report. [Flow calculations for combustors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bloom, M.H.; Lederman, S.; Sforza, P.

1980-01-01

This is Part II of the Technical Progress Report on Tasks II-IV of the subject contract. It deals sequentially with Diagnostics and Instrumentation, the MHD Channel and the Combustor. During this period, a significant effort has gone into establishing a schematic design of a laser diagnostic system which can be applied to the flow-train of the MHD system, and to acquiring, assembling and shaking down a laboratory set-up upon which a prototype can be based. With further reference to the MHD Channel, a model analysis has been initiated of the two-dimensional MHD boundary layer between two electrodes in the limitmore » of small magnetic Reynolds numbers with negligible effect of the flow on the applied magnetic field. An objective of this model study is the assessment of variations in initial conditions on the boundary layer behavior. Finally, the problem of combustion modeling has been studied on an initial basis. The open reports on this subject depict a high degree of empiricism, centering attention on global behavior mainly. A quasi-one-dimensional model code has been set-up to check some of the existing estimates. Also a code for equilibrium combustion has been activated.« less

Theoretical analysis of non-linear Joule heating effects over an electro-thermal patterned flow

NASA Astrophysics Data System (ADS)

Sanchez, Salvador; Ascanio, Gabriel; Mendez, Federico; Bautista, Oscar

2017-11-01

In this work, non-linear Joule heating effects for electro-thermal patterned flows driven inside of a slit microchannel are analyzed. Here, the movement of fluids is controlled by placing electro-thermal forces, which are generated through an imposed longitudinal electric field, E0, and the wall electric potential produced by electrodes inserted along the surface of the microchannel wall, ζ. For this analysis, viscosity and electrical conductivity of fluids are included as known functions, which depend on the temperature; therefore, in order to determine the flow, temperature and electric potential fields together with its simultaneous interactions, the equations of continuity, momentum, energy, charges distribution and electrical current have to be solved in a coupled manner. The main results obtained in the study reveal that with the presence of thermal gradients along of the microchannel, local electro-thermal forces, Fχ, are affected in a sensible manner, and consequently, the flow field is modified substantially, causing the interruption or intensification of recirculations along of the microchannel. This work was supported by the Fondo SEP-CONACYT through research Grants No. 220900 and 20171181 from SIP-IPN. F. Mendez acknowledges support from PAPIIT-UNAM under Contract Number IN112215. S. Sanchez thanks to DGAPA-UNAM for the postdoctoral fellowship.

Experimental investigation of generic three-dimensional sidewall-compression scramjet inlets at Mach 6 in tetrafluoromethane

NASA Technical Reports Server (NTRS)

Holland, Scott D.

1993-01-01

Three-dimensional sidewall-compression scramjet inlets with leading-edge sweeps of 30 deg and 70 deg were tested in the Langley Hypersonic CF4 Tunnel at Mach 6 and with a ratio of specific heats of 1.2. The parametric effects of leading-edge sweep, cowl position, contraction ratio, and Reynolds number were investigated. The models were instrumented with 42 static pressure orifices that were distributed on the sidewalls, base plate, and cowl. Schlieren movies were made of each test for flow visualization of the effects of the internal flow spillage on the external flow field. To obtain an approximate characterization of the flow field, a modification to two-dimensional, inviscid, oblique shock theory was derived to accommodate the three-dimensional effects of leading-edge sweep. This theory qualitatively predicted the reflected shock structure (i.e., sidewall impingement locations) and the observed increase in spillage with increasing leading-edge sweep. The primary effect of moving the cowl forward was capturing the flow that would have otherwise spilled out ahead of the cowl. Increasing the contraction ratio increases the number of internal shock reflections and hence incrementally increases the sidewall pressure distribution. Significant Reynolds number effects were noted over a small range of Reynolds number.

Inertial focusing in a straight channel with asymmetrical expansion-contraction cavity arrays using two secondary flows

NASA Astrophysics Data System (ADS)

Zhang, J.; Li, M.; Li, W. H.; Alici, G.

2013-08-01

The focusing of particles has a variety of applications in industry and biomedicine, including wastewater purification, fermentation filtration, and pathogen detection in flow cytometry, etc. In this paper a novel inertial microfluidic device using two secondary flows to focus particles is presented. The geometry of the proposed microfluidic channel is a simple straight channel with asymmetrically patterned triangular expansion-contraction cavity arrays. Three different focusing patterns were observed under different flow conditions: (1) a single focusing streak on the cavity side; (2) double focusing streaks on both sides; (3) half of the particles were focused on the opposite side of the cavity, while the other particles were trapped by a horizontal vortex in the cavity. The focusing performance was studied comprehensively up to flow rates of 700 µl min-1. The focusing mechanism was investigated by analysing the balance of forces between the inertial lift forces and secondary flow drag in the cross section. The influence of particle size and cavity geometry on the focusing performance was also studied. The experimental results showed that more precise focusing could be obtained with large particles, some of which even showed a single-particle focusing streak in the horizontal plane. Meanwhile, the focusing patterns and their working conditions could be adjusted by the geometry of the cavity. This novel inertial microfluidic device could offer a continuous, sheathless, and high-throughput performance, which can be potentially applied to high-speed flow cytometry or the extraction of blood cells.

Machine learning plus optical flow: a simple and sensitive method to detect cardioactive drugs

NASA Astrophysics Data System (ADS)

Lee, Eugene K.; Kurokawa, Yosuke K.; Tu, Robin; George, Steven C.; Khine, Michelle

2015-07-01

Current preclinical screening methods do not adequately detect cardiotoxicity. Using human induced pluripotent stem cell-derived cardiomyocytes (iPS-CMs), more physiologically relevant preclinical or patient-specific screening to detect potential cardiotoxic effects of drug candidates may be possible. However, one of the persistent challenges for developing a high-throughput drug screening platform using iPS-CMs is the need to develop a simple and reliable method to measure key electrophysiological and contractile parameters. To address this need, we have developed a platform that combines machine learning paired with brightfield optical flow as a simple and robust tool that can automate the detection of cardiomyocyte drug effects. Using three cardioactive drugs of different mechanisms, including those with primarily electrophysiological effects, we demonstrate the general applicability of this screening method to detect subtle changes in cardiomyocyte contraction. Requiring only brightfield images of cardiomyocyte contractions, we detect changes in cardiomyocyte contraction comparable to - and even superior to - fluorescence readouts. This automated method serves as a widely applicable screening tool to characterize the effects of drugs on cardiomyocyte function.

Model development of supersonic trough wind with shocks

NASA Technical Reports Server (NTRS)

Grebowsky, J. M.

1972-01-01

The time dependent one dimensional hydrodynamic equations describe the evolution of the thermal plasma flow along closed magnetic field lines outside of the plasmasphere. The convection of the supersonic polar wind onto a closed fieldline results in the assumed formation of collisionless plasma shocks. These shocks move earthward as the field line with its frozen-in plasma remains fixed or contracts with time to smaller L coordinates. The high equatorial plasma temperature (of the order of electron volts) produced by the shock process decreases with time if the flow is isothermal but it will increase if the contraction is under adiabatic conditions. Assuming adiabaticity a peak in the temperature forms at the equator in conjunction with a depression in the ion density. After an initial contraction, if the flux tube drifts to higher L coordinates the direction of the shock motion can be reversed so that the supersonic region will expand along the field line towards the state characterizing the supersonic polar wind. A rapid expansion will lower the equatorial density while the temperature decreases with time under adiabatic but not isothermal conditions.

Analysis of intra-uterine fluid motion induced by uterine contractions.

PubMed

Eytan, O; Elad, D

1999-03-01

Evaluation of the fluid flow pattern in a non-pregnant uterus is important for understanding embryo transport in the uterus. Fertilization occurs in the fallopian tube and the embryo (fertilized ovum) enters the uterine cavity within 3 days of ovulation. In the uterus, the embryo is conveyed by the uterine fluid for another 3 to 4 days to a successful implantation site at the upper part of the uterus. Fluid movements within the uterus may be induced by several mechanisms, but they seem to be dominated by myometrial contractions. Intra-uterine fluid transport in a sagittal cross-section of the uterus was simulated by a model of wall-induced fluid motion within a two-dimensional channel. The time-dependent fluid pattern was studied by employing the lubrication theory. A comprehensive analysis of peristaltic transport resulting from symmetric and asymmetric contractions is presented for various displacement waves on the channel walls. The results provide information on the flow field and possible trajectories by which an embryo may be transported before implantation at the uterine wall.

Bubble Augmented Propulsor Mixture Flow Simulation near Choked Flow Condition

NASA Astrophysics Data System (ADS)

Choi, Jin-Keun; Hsiao, Chao-Tsung; Chahine, Georges

2013-03-01

The concept of waterjet thrust augmentation through bubble injection has been the subject of many patents and publications over the past several decades, and computational and experimental evidences of the augmentation of the jet thrust through bubble growth in the jet stream have been reported. Through our experimental studies, we have demonstrated net thrust augmentation as high as 70%for air volume fractions as high as 50%. However, in order to enable practical designs, an adequately validated modeling tool is required. In our previous numerical studies, we developed and validated a numerical code to simulate and predict the performance of a two-phase flow water jet propulsion system for low void fractions. In the present work, we extend the numerical method to handle higher void fractions to enable simulations for the high thrust augmentation conditions. At high void fractions, the speed of sound in the bubbly mixture decreases substantially and could be as low as 20 m/s, and the mixture velocity can approach the speed of sound in the medium. In this numerical study, we extend our numerical model, which is based on the two-way coupling between the mixture flow field and Lagrangian tracking of a large number of bubbles, to accommodate compressible flow regimes. Numerical methods used and the validation studies for various flow conditions in the bubble augmented propulsor will be presented. This work is supported by Office of Naval Research through contract N00014-11-C-0482 monitored by Dr. Ki-Han Kim.

Static Verification for Code Contracts

NASA Astrophysics Data System (ADS)

Fähndrich, Manuel

The Code Contracts project [3] at Microsoft Research enables programmers on the .NET platform to author specifications in existing languages such as C# and VisualBasic. To take advantage of these specifications, we provide tools for documentation generation, runtime contract checking, and static contract verification.

Combined Effect of Contraction Ratio and Chamber Pressure on the Performance of a Gaseous Hydrogen-Liquid-Oxygen Combustor for a Given Propellant Weight Flow and Oxidant-Fuel Ratio

NASA Technical Reports Server (NTRS)

Hersch, Martin

1961-01-01

The effect of contraction ratio and chamber pressure on the combustion performance of a gaseous-hydrogen-liquid-oxygen combustor was investigated analytically and experimentally. The experiment was conducted with a "two-dimensional" gaseous-hydrogen-liquid-oxygen engine of about 150-pound thrust. The contraction ratio was varied from 1.5 to 6 by changing the nozzle throat area. This variation resulted in a chamber pressure variation of about 25 to 120 pounds per square inch. The experimental results were corrected for heat transfer to the engine walls and momentum pressure losses. The experimental performance, as evaluated in terms of characteristic exhaust velocity, was 98 percent of theoretical at contraction ratios greater than 3 but decreased very rapidly at smaller contraction ratios. The heat-transfer rate increased with increasing contraction ratio and chamber pressure; it was about 1 Btu per square inch per second at a contraction ratio of 1.5 and increased to about 3 at a contraction ratio of 6. The combined effects of contraction-ratio and chamber-pressure changes on performance were investigated analytically with a mixing model and a vaporization model. The mixing model predicted very poor mixing at contraction ratios below 3 and almost perfect mixing at higher contraction ratios. The performance predicted by the vaporization model was very close to 100 percent for all contraction ratios. From these results, it was concluded that the performance was limited by poor mixing at low contraction ratios and chamber pressures.

Exploring the use of optical flow for the study of functional NIRS signals

NASA Astrophysics Data System (ADS)

Fernandez Rojas, Raul; Huang, Xu; Ou, Keng-Liang; Hernandez-Juarez, Jesus

2017-03-01

Near infrared spectroscopy (NIRS) is an optical imaging technique that allows real-time measurements of Oxy and Deoxy-hemoglobin concentrations in human body tissue. In functional NIRS (fNIRS), this technique is used to study cortical activation in response to changes in neural activity. However, analysis of activation regions using NIRS is a challenging task in the field of medical image analysis and despite existing solutions, no homogeneous analysis method has yet been determined. For that reason, the aim of our present study is to report the use of an optical flow method for the analysis of cortical activation using near-infrared spectroscopy signals. We used real fNIRS data recorded from a noxious stimulation experiment as base of our implementation. To compute the optical flow algorithm, we first arrange NIRS signals (Oxy-hemoglobin) following our 24 channels (12 channels per hemisphere) head-probe configuration to create image-like samples. We then used two consecutive fNIRS samples per hemisphere as input frames for the optical flow algorithm, making one computation per hemisphere. The output from these two computations is the velocity field representing cortical activation from each hemisphere. The experimental results showed that the radial structure of flow vectors exhibited the origin of cortical activity, the development of stimulation as expansion or contraction of such flow vectors, and the flow of activation patterns may suggest prediction in cortical activity. The present study demonstrates that optical flow provides a power tool for the analysis of NIRS signals. Finally, we suggested a novel idea to identify pain status in nonverbal patients by using optical flow motion vectors; however, this idea will be study further in our future research.

48 CFR 1335.014 - Government property and title.

Code of Federal Regulations, 2010 CFR

2010-10-01

... primary purpose is the conduct of scientific research is set forth in CAM 1301.70. ... CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1335.014 Government property and title. The...

48 CFR 1335.014 - Government property and title.

Code of Federal Regulations, 2011 CFR

2011-10-01

... primary purpose is the conduct of scientific research is set forth in CAM 1301.70. ... CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1335.014 Government property and title. The...

A New Availability-Payment Model for Pricing Performance-Based Logistics Contracts

DTIC Science & Technology

2014-06-17

the contractor maintains a steady revenue (with profit ). Figure 4. Affine Controller Model for Availability Contract Acquisition Research Program... a bankruptcy constraint; and and Deduction(∙) are decision variables for contract design for the level one (public sector) problem. Given...UMD-CM-14-175 ACQUISITION RESEARCH PROGRAM SPONSORED REPORT SERIES A New “Availability-Payment” Model for Pricing Performance- Based

48 CFR 35.011 - Data.

Code of Federal Regulations, 2011 CFR

2011-10-01

... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.011 Data. (a) R&D contracts shall specify the technical..., drawings, specifications, and other descriptive information) that can be used to achieve competition in...

48 CFR 35.011 - Data.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.011 Data. (a) R&D contracts shall specify the technical..., drawings, specifications, and other descriptive information) that can be used to achieve competition in...

48 CFR 35.011 - Data.

Code of Federal Regulations, 2012 CFR

2012-10-01

... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.011 Data. (a) R&D contracts shall specify the technical..., drawings, specifications, and other descriptive information) that can be used to achieve competition in...

48 CFR 35.011 - Data.

Code of Federal Regulations, 2014 CFR

2014-10-01

... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.011 Data. (a) R&D contracts shall specify the technical..., drawings, specifications, and other descriptive information) that can be used to achieve competition in...

48 CFR 35.011 - Data.

Code of Federal Regulations, 2013 CFR

2013-10-01

... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.011 Data. (a) R&D contracts shall specify the technical..., drawings, specifications, and other descriptive information) that can be used to achieve competition in...

The U.S. Public's Investment in Medical Research: An Evolving Social Contract.

PubMed

Heinig, Stephen J; Dev, Anurupa; Bonham, Ann C

2016-01-01

Medical researchers and their institutions are operating under extraordinary financial stress. More than a decade after completion of the 5-year doubling of the National Institutes of Health budget, the medical research community must confront a significant loss in National Institutes of Health purchasing power and downward pressures in federal discretionary spending. In part, this trend results from a federal budget stalemate over the growth in entitlement programs, particularly spending on medical care. This article considers the changing nature of the federal investment in medical research and the potential for medical researchers and institutions conducting the full spectrum of research to improve health system performance and health equity. In our view, continued federal investments reflect an evolving social contract for research serving the public good; the term contract is used metaphorically to represent a figurative, implicit agreement between the scientific community and the public's representatives in government. Under this conceptual contract, the American people--who are ultimately the funders of research, research training and infrastructure--expect outcomes that lead to better health, security or other benefits. The evolving contract includes expectations for more accountability, transparency, sharing of results and resources, and better integration of research systems and cultures that used to take pride in boundaries and distinctions. We outline here some of the major movements of organizations realigning to social support, which are increasingly essential to sustain public investment in medical research. Copyright © 2016 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.

United States private-sector physicians and pharmaceutical contract research: a qualitative study.

PubMed

Fisher, Jill A; Kalbaugh, Corey A

2012-01-01

There have been dramatic increases over the past 20 years in the number of nonacademic, private-sector physicians who serve as principal investigators on US clinical trials sponsored by the pharmaceutical industry. However, there has been little research on the implications of these investigators' role in clinical investigation. Our objective was to study private-sector clinics involved in US pharmaceutical clinical trials to understand the contract research arrangements supporting drug development, and specifically how private-sector physicians engaged in contract research describe their professional identities. We conducted a qualitative study in 2003-2004 combining observation at 25 private-sector research organizations in the southwestern United States and 63 semi-structured interviews with physicians, research staff, and research participants at those clinics. We used grounded theory to analyze and interpret our data. The 11 private-sector physicians who participated in our study reported becoming principal investigators on industry clinical trials primarily because contract research provides an additional revenue stream. The physicians reported that they saw themselves as trial practitioners and as businesspeople rather than as scientists or researchers. Our findings suggest that in addition to having financial motivation to participate in contract research, these US private-sector physicians have a professional identity aligned with an industry-based approach to research ethics. The generalizability of these findings and whether they have changed in the intervening years should be addressed in future studies. Please see later in the article for the Editors' Summary.

United States Private-Sector Physicians and Pharmaceutical Contract Research: A Qualitative Study

PubMed Central

Fisher, Jill A.; Kalbaugh, Corey A.

2012-01-01

Background There have been dramatic increases over the past 20 years in the number of nonacademic, private-sector physicians who serve as principal investigators on US clinical trials sponsored by the pharmaceutical industry. However, there has been little research on the implications of these investigators' role in clinical investigation. Our objective was to study private-sector clinics involved in US pharmaceutical clinical trials to understand the contract research arrangements supporting drug development, and specifically how private-sector physicians engaged in contract research describe their professional identities. Methods and Findings We conducted a qualitative study in 2003–2004 combining observation at 25 private-sector research organizations in the southwestern United States and 63 semi-structured interviews with physicians, research staff, and research participants at those clinics. We used grounded theory to analyze and interpret our data. The 11 private-sector physicians who participated in our study reported becoming principal investigators on industry clinical trials primarily because contract research provides an additional revenue stream. The physicians reported that they saw themselves as trial practitioners and as businesspeople rather than as scientists or researchers. Conclusions Our findings suggest that in addition to having financial motivation to participate in contract research, these US private-sector physicians have a professional identity aligned with an industry-based approach to research ethics. The generalizability of these findings and whether they have changed in the intervening years should be addressed in future studies. Please see later in the article for the Editors' Summary. PMID:22911055

Multi-Task Project to Provide Research Support for Human Research and Engineering Goals Identified by the Army

DTIC Science & Technology

2009-06-01

Jefferson City, MO Phone:573-681-5126 E-mail: rooneyi(a>lincolnu.edu Principle Investigators for contract’s 5 Task Areas: Task I : James Rooney...identified Tasks all structured within a single contract. This contract contained Five Task areas: Task I was an administrative task; Task II-V were...Manager’s Overview of the Report (Task I ) 3. Summary Final Budget Invoice and Budget unspent balance 4. Technical Reports of the Research Tasks (II - V

Contracts for field projects and supporting research on enhanced oil recovery. Progress review number 83, quarter ending June 30, 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

Summaries of 41 research projects on enhanced recovery are presented under the following sections: (1) chemical flooding; (2) gas displacement; (3) thermal recovery; (4) geoscience technology; (5) resource assessment technology; and (6) reservoir classes. Each presentation gives the title of the project, contract number, research facility, contract date, expected completion data, amount of the award, principal investigator, and DOE program manager, and describes the objectives of the project and a summary of the technical progress.

48 CFR 5.205 - Special situations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... PUBLICIZING CONTRACT ACTIONS Synopses of Proposed Contract Actions 5.205 Special situations. (a) Research and... interest in potential R&D programs whenever market research does not produce a sufficient number of... subsequent solicitation. Advanced notices must be entitled “Research and Development Sources Sought” and...

48 CFR 5.205 - Special situations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... interest in potential R&D programs whenever market research does not produce a sufficient number of... PUBLICIZING CONTRACT ACTIONS Synopses of Proposed Contract Actions 5.205 Special situations. (a) Research and... subsequent solicitation. Advanced notices must be entitled “Research and Development Sources Sought” and...

Administrative Computing: Ideas That Work.

ERIC Educational Resources Information Center

White, Lawrence S.

1984-01-01

Describes administrative computer use in the Concord (NH) School District. Applications discussed include procurement, cash flow and investment, accounting and control, and teacher contracts, all performed with in-house programs. (MCG)

Evaluation of bridge-scour data at selected sites in Ohio

USGS Publications Warehouse

Jackson, K.S.

1997-01-01

Scour data collected during 1989-94 were evaluated to determine whether pier scour and contraction scour occurred at 22 bridge sites in Ohio. Pier-scour depths computed from selected pier-scour prediction equations were compared with measured pier-scour depths, and the accuracy of the prediction equations were evaluated. Observed pier-scour relations were compared to relations developed through laboratory research. Mean streambed elevations were evaluated to determine the depth of contraction scour. Channel stability was assessed by use of mean streambed elevations at the approach section. Ground-penetrating radar was used at all sites to investigate the presence of historical scour. Pier scour was observed in 45 of 47 scour measurements made during floods; 84 cases of pier scour were documented, 83 at solid-wall piers and 1 at a capped-pile type pier. Estimated recurrence intervals for 27 of the 35 measured streamflows, all on unregulated streams, were less than 2 years. Seventeen pier-scour prediction equations were evaluated. The Froehlich Design equation was found to most closely meet the 'best design equation' criteria for all 84 cases of the observed data. The Larras equation was found to be the best design equation for the observed data where approach-flow attack angles were 10 degrees or less. Observed pier-scour depths and flow depths ranged from 0.5 to 6.1 feet and 3.0 to 19.8 feet, respectively. All pier-scour depths were less than 2.4 times the corresponding pier width. Selected factors were normalized by dividing by effective pier width. LOWESS curves were developed using the 84 cases of observed pier scour. Normalized scour depth increased with normalized flow depth; however, the rate of increase appeared to lessen as normalized flow depth exceeded 2.5. Normalized scour depths increased rapidly as flow intensity approached the threshold value of 1 and then decreased as flow intensities exceeded this threshold. Normalized scour depth was found to increase with Froude number, and a steeper slope was evident for Froude numbers exceeding 0.2. Normalized scour depth was found to increase with median grain size up to about 10 millimeters for bed material near the pier, then decrease for median grain sizes greater than 10 millimeters. Normalized scour depth was also found to decrease as sediment gradation of bed material near the pier increased. The observed pier-scour relations determined from the field measurements tend to support conclusions by previous researchers of streambed scour, except for the previous finding that normalized scour depth decreases consistently with increasing median grain size. Possible factors that may have influenced the observed trends in the relation between normalized scour depth and median grain size in this study are cohesion and scour measurements made at nonequilibrium conditions. LOWESS curves were developed for 45 of 84 cases of observed pier scour where approach-flow attack angles were less than or equal to 10 degrees. These curves were visually compared to LOWESS curves developed from all observations of pier scour. For three relations, differences in the trends of the LOWESS curves were of sufficient magnitude to warrant discussion. Contraction scour was observed in 4 of the 47 scour measurements and ranged from 0.8 to2.3 feet in depth. Analysis of annual mean streambed approach-section elevations indicated that approach sections were generally stable at 18 of the 22 sites. Ground-penetrating radar, a geophysical method that enables subsurface exploration of the streambed when conditions are favorable, was used at all sites to determine whether historical scour had occurred. Results of the ground-penetrating radar surveys at 20 sites in 1990 indicated the presence of historical scour surfaces at 5 sites. At four of the five sites showing evidence of possible historical scour, differences between the estimated depth of historical scour and the maximum observed scour were w

Contracts.

ERIC Educational Resources Information Center

Gellert, Shepard D.; Wilson, Grace

1977-01-01

This paper reviews experimental psychology goal research and its implications for the therapist doing contract therapy. Clinical examples of various levels of contracts give illustrations, and a technique, the therapeutic double bind, as a form of contract, is detailed. A case study is presented to illustrate the use of the theory. Three…

Urethral anatomy and semen flow during ejaculation

NASA Astrophysics Data System (ADS)

Kelly, Diane

2016-11-01

Ejaculation is critical for reproductive success in many animals, but little is known about its hydrodynamics. In mammals, ejaculation pushes semen along the length of the penis through the urethra. Although the urethra also carries urine during micturition, the flow dynamics of micturition and ejaculation differ: semen is more viscous than urine, and the pressure that drives its flow is derived primarily from the rhythmic contractions of muscles at the base of the penis, which produce pulsatile rather than steady flow. In contrast, Johnston et al. (2014) describe a steady flow of semen through the crocodilian urethral groove during ejaculation. Anatomical differences of tissues associated with mammalian and crocodilian urethral structures may underlie these differences in flow behavior.

Software With Strong Ties to Space

NASA Technical Reports Server (NTRS)

2003-01-01

TieFlow is a simple but powerful business process improvement solution. It can automate and simplify any generic or industry-specific work process, helping organizations to transform work inefficiencies and internal operations involving people, paper, and procedures into a streamlined, well-organized, electronicbased process. TieFlow increases business productivity by improving process cycle times. The software can expedite generic processes in the areas of product design and development, purchase orders, expense reports, benefits enrollment, budgeting, hiring, and sales. It can also shore up vertical market processes such as claims processing, loan application and processing, health care administration, contract management, and advertising agency traffic. The processes can be easily and rapidly captured in a graphical manner and enforced together with rules pertaining to assignments that need to be performed. Aside from boosting productivity, TieFlow also reduces organizational costs and errors. TieFlow was developed with Small Business Innovation Research (SBIR) assistance from Johnson. The SBIR support entitles all Federal Government agencies to utilize the TieFlow software technology free of charge. Tietronix emphasizes that TieFlow is an outstanding workflow resource that could produce dramatic productivity and cost improvements for all agencies, just as it has done and continues to do for NASA. The Space Agency is currently using the software throughout several mission-critical offices, including the Mission Operations Directorate and the Flight Director s Office, for worldwide participation of authorized users in NASA processes. At the Flight Director s Office, TieFlow allows personnel to electronically submit and review changes to the flight rules carried out during missions.

Investigation of advanced counterrotation blade configuration concepts for high speed turboprop systems. Task 4: Advanced fan section aerodynamic analysis

NASA Technical Reports Server (NTRS)

Crook, Andrew J.; Delaney, Robert A.

1992-01-01

The purpose of this study is the development of a three-dimensional Euler/Navier-Stokes flow analysis for fan section/engine geometries containing multiple blade rows and multiple spanwise flow splitters. An existing procedure developed by Dr. J. J. Adamczyk and associates and the NASA Lewis Research Center was modified to accept multiple spanwise splitter geometries and simulate engine core conditions. The procedure was also modified to allow coarse parallelization of the solution algorithm. This document is a final report outlining the development and techniques used in the procedure. The numerical solution is based upon a finite volume technique with a four stage Runge-Kutta time marching procedure. Numerical dissipation is used to gain solution stability but is reduced in viscous dominated flow regions. Local time stepping and implicit residual smoothing are used to increase the rate of convergence. Multiple blade row solutions are based upon the average-passage system of equations. The numerical solutions are performed on an H-type grid system, with meshes being generated by the system (TIGG3D) developed earlier under this contract. The grid generation scheme meets the average-passage requirement of maintaining a common axisymmetric mesh for each blade row grid. The analysis was run on several geometry configurations ranging from one to five blade rows and from one to four radial flow splitters. Pure internal flow solutions were obtained as well as solutions with flow about the cowl/nacelle and various engine core flow conditions. The efficiency of the solution procedure was shown to be the same as the original analysis.

48 CFR 1352.235-73 - Research involving human subjects-after initial contract award.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Research involving human... Provisions and Clauses 1352.235-73 Research involving human subjects—after initial contract award. As prescribed in 48 CFR 1335.006(d), insert the following clause: Research Involving Human Subjects—After...

48 CFR 1352.235-73 - Research involving human subjects-after initial contract award.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Research involving human... Provisions and Clauses 1352.235-73 Research involving human subjects—after initial contract award. As prescribed in 48 CFR 1335.006(d), insert the following clause: Research Involving Human Subjects—After...

48 CFR 1352.235-73 - Research involving human subjects-after initial contract award.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Research involving human... Provisions and Clauses 1352.235-73 Research involving human subjects—after initial contract award. As prescribed in 48 CFR 1335.006(d), insert the following clause: Research Involving Human Subjects—After...

Hedgehogs, Foxes, Ethics, and the Evolving Social Contract in Psychology.

ERIC Educational Resources Information Center

Rosnow, Ralph L.

This paper discusses the importance of ethics in psychological research. It defines the social contract between psychological science and society as the responsibility not to do psychological or physical harm to any research participants and to do beneficial research in a way that will produce valid research. Also explored are ways in which…

Small Business Innovation Research GRC Phase I, Phase II, and Post-Phase II Opportunity Assessment for 2015

NASA Technical Reports Server (NTRS)

Nguyen, Hung D.; Steele, Gynelle C.

2016-01-01

This report outlines the 2015 Small Business Innovation Research/Small Business Technology Transfer (SBIR/STTR) Phase I, Phase II, and Post-Phase II opportunity contract award results associated with NASA's Aeronautics Research Mission Directorate (ARMD), Human Exploration and Operations Mission Directorate (HEOMD), Science Mission Directorate (SMD), and Space Technology Mission Directorate (STMD) for NASA Glenn Research Center. The report also highlights the number of Phase I, Phase II, and Post-Phase II contracts awarded by mission directorate. The 2015 Phase I contract awards to companies in Ohio and their corresponding technologies are also discussed.

Age 60 rule research, part I : bibliographic database.

DOT National Transportation Integrated Search

1994-10-01

This document is one of four products completed as a part of the Age 60 Rule research contract monitored by Pam Della Rocco, Civil Aerospace Medical Institute. As part of their research contract with the FAA to study issues related to the "Age 60 Rul...

Effects of axisymmetric contractions on turbulence of various scales

NASA Technical Reports Server (NTRS)

Tan-Atichat, J.; Nagib, H. M.; Drubka, R. E.

1980-01-01

Digitally acquired and processed results from an experimental investigation of grid generated turbulence of various scales through and downstream of nine matched cubic contour contractions ranging in area ratio from 2 to 36, and in length to inlet diameter ratio from 0.25 to 1.50 are reported. An additional contraction with a fifth order contour was also utilized for studying the shape effect. Thirteen homogeneous and nearly isotropic test flow conditions with a range of turbulence intensities, length scales and Reynolds numbers were generated and used to examine the sensitivity of the contractions to upstream turbulence. The extent to which the turbulence is altered by the contraction depends on the incoming turbulence scales, the total strain experienced by the fluid, as well as the contraction ratio and the strain rate. Varying the turbulence integral scale influences the transverse turbulence components more than the streamwise component. In general, the larger the turbulence scale, the lesser the reduction in the turbulence intensity of the transverse components. Best agreement with rapid distortion theory was obtained for large scale turbulence, where viscous decay over the contraction length was negligible, or when a first order correction for viscous decay was applied to the results.

Laminar and Turbulent Flow Calculations for the Hifire-5B Flight Test

DTIC Science & Technology

2017-11-01

STATES AIR FORCE AFRL-RQ-WP-TP-2017-0172 LAMINAR AND TURBULENT FLOW CALCULATIONS FOR THE HIFIRE-5B FLIGHT TEST Roger L. Kimmel Hypersonic Sciences...LAMINAR AND TURBULENT FLOW CALCULATIONS FOR THE HIFIRE-5B FLIGHT TEST 5a. CONTRACT NUMBER In-house 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER...Clearance Date: 28 Apr 2017 14. ABSTRACT The HIFiRE-5b program launched an experimental FLight test vehicle to study laminar-turbulent transition

Exploring Capabilities of Electrical Capacitance Tomography Sensor and Velocity Analysis of Two-Phase R-134A Flow Through a Sudden Expansion

DTIC Science & Technology

2017-05-01

SUDDEN EXPANSION 5a. CONTRACT NUMBER In-house 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 62203F 6. AUTHOR(S) Joseph Michael Cronin 5d. PROJECT ...heat transfer in order to manage the ever-increasing airframe and engine heat loads. Two-phase liquid-vapor refrigerant systems are one solution for...were compared with pressure drop correlations. 15. SUBJECT TERMS thermal management , two-phase flow, flow visualization, electric capacitance

Control of Heat Fluxes on the Surface of the Body Streamlined by Supersonic Flow with the Help of MHD Method

DTIC Science & Technology

2008-10-01

Supersonic Flow with the Help of MHD Method 5a. CONTRACT NUMBER ISTC Registration No: 3475 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6...MONITOR’S ACRONYM(S) 11. SPONSOR/MONITOR’S REPORT NUMBER(S) ISTC 05-7004 12. DISTRIBUTION/AVAILABILITY STATEMENT Approved for public release...Center ( ISTC ), Moscow. ISTC Project No. 3475р Control of heat fluxes on the surface of the body streamlined by supersonic flow with the help of MHD

Multigrid solution of internal flows using unstructured solution adaptive meshes

NASA Technical Reports Server (NTRS)

Smith, Wayne A.; Blake, Kenneth R.

1992-01-01

This is the final report of the NASA Lewis SBIR Phase 2 Contract Number NAS3-25785, Multigrid Solution of Internal Flows Using Unstructured Solution Adaptive Meshes. The objective of this project, as described in the Statement of Work, is to develop and deliver to NASA a general three-dimensional Navier-Stokes code using unstructured solution-adaptive meshes for accuracy and multigrid techniques for convergence acceleration. The code will primarily be applied, but not necessarily limited, to high speed internal flows in turbomachinery.

48 CFR 1832.412 - Contract clause. (NASA supplement paragraphs (e) and (f))

Code of Federal Regulations, 2014 CFR

2014-10-01

... AERONAUTICS AND SPACE ADMINISTRATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Advance Payments for... the Small Business Innovation Research (SBIR) or Small Business Technology Transfer (STTR) programs...

48 CFR 1832.412 - Contract clause. (NASA supplement paragraphs (e) and (f))

Code of Federal Regulations, 2011 CFR

2011-10-01

... AERONAUTICS AND SPACE ADMINISTRATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Advance Payments for... the Small Business Innovation Research (SBIR) or Small Business Technology Transfer (STTR) programs...

48 CFR 1832.412 - Contract clause. (NASA supplement paragraphs (e) and (f))

Code of Federal Regulations, 2010 CFR

2010-10-01

... AERONAUTICS AND SPACE ADMINISTRATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Advance Payments for... the Small Business Innovation Research (SBIR) or Small Business Technology Transfer (STTR) programs...

48 CFR 1832.412 - Contract clause. (NASA supplement paragraphs (e) and (f))

Code of Federal Regulations, 2012 CFR

2012-10-01

... AERONAUTICS AND SPACE ADMINISTRATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Advance Payments for... the Small Business Innovation Research (SBIR) or Small Business Technology Transfer (STTR) programs...

48 CFR 1832.412 - Contract clause. (NASA supplement paragraphs (e) and (f))

Code of Federal Regulations, 2013 CFR

2013-10-01

... AERONAUTICS AND SPACE ADMINISTRATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Advance Payments for... the Small Business Innovation Research (SBIR) or Small Business Technology Transfer (STTR) programs...

Army Contract Specialists’ Lack of Desire to Become Contracting Officers

DTIC Science & Technology

2012-05-01

management positions. In researching this matter, the author will utilize a mixed method research approach which employs both qualitative and...literature available and relevance. Chapter 3 presents the methods used to conduct the research and discusses why qualitative interviews and survey research ...This research study will utilize a qualitative method with roots in traditional ethnographic research , in helping to achieve the objective of