Effect of Isometric Hand Grip Exercises on Blood Flow and Placement of IV Catheters for Administration of Chemotherapy.

PubMed

Ozkaraman, Ayse; Yesilbalkan, Öznur Usta

2016-04-01

Complications may occur in the subcutaneous or subdermal tissues during IV administration of chemotherapy related to blood flow and catheter placement. Daily isometric hand grip exercises were evaluated for their effect on blood flow in the vessels of the nondominant arm before placement of IV catheters and the success rate of IV catheter placement on the first attempt. The study focused on patients with non-Hodgkin lymphoma receiving the first and second cycles of chemotherapy. The intervention group performed daily isometric hand grip exercises before chemotherapy with peripheral catheter insertion. The control group performed routine activities only. Blood flow was measured by ultrasound in the brachial artery (BA) and brachial vein (BV) of the nondominant arm before the first (T1) and second (T2) cycles of chemotherapy. Blood flow slightly increased in the intervention group at T2 compared to T1. In the control group, blood flow decreased in the BA and did not change in the BV at T2 compared to T1. The success rate for first-attempt placement of a peripheral IV catheter was the same for the intervention and control groups.

Theoretical and numerical studies on physics and dynamics of orographic precipitation associated with tropical cyclones over mesoscale mountains

NASA Astrophysics Data System (ADS)

Sever, Gokhan

A series of systematic two/three-dimensional (2D/3D) idealized numerical experiments were conducted to investigate the combined effects of dynamical and physical processes on orographic precipitation (OP) with varying incoming basic flow speed (U) and CAPE in a conditionally unstable uniform flow. The three moist flow regimes identified by Chu and Lin are reproduced using the CM1 model in low resolution (Deltax = 1 km) 2D simulations. A new flow regime, namely Regime IV (U > 36 m s-1) is characterized by gravity waves, heavy precipitation, lack of upper-level wave breaking and turbulence over the lee slope. The regime transition from III to IV at about 36 m s -1 can be explained by the transition from upward propagating gravity waves to evanescent flow, which can be predicted using a moist mountain wave theory. Although the basic features are captured well in low grid resolutions, high resolution (Deltax = 100 m) 2D/3D simulations are required to resolve precipitation distribution and intensity at higher basic winds (U > 30 m s -1). These findings may be applied to examine the performance of moist and turbulence parameterization schemes. Based on 3D simulations, gravity wave-induced severe downslope winds and turbulent mixing within hydraulic jump reduce OP in Regime III. Then in Regime IV, precipitation amount and spatial extent are intensified as the upper-level wave breaking vanishes and updrafts strengthen. Similar experiments were performed with a low CAPE sounding to assess the evolution of OP in an environment similar to that observed in tropical cyclones. These low CAPE simulations show that precipitation is nearly doubled at high wind speeds compared to high CAPE results. Based on a microphysics budget analysis, two factors are identified to explain this difference: 1) warm-rain formation processes (auto-conversion and accretion), which are more effective in low CAPE environment, and 2) even though rain production (via graupel and snow melting) is intense in high CAPE, strong downdrafts and advection induced evaporation tend to deplete precipitation before reaching the ground. Overall, both in 2D/3D high wind speed simulations, the pattern of the precipitation distribution resembles to the bell-shaped mountain profile with maximum located over the mountain peak. This result has a potential to simplify the parameterization of OP in terms of two control parameters and might applicable to global weather and climate modeling.

Flow injection chemiluminescence determination of the total phenolics levels in plant-derived beverages using soluble manganese(IV).

PubMed

Nalewajko-Sieliwoniuk, Edyta; Tarasewicz, Iwona; Kojło, Anatol

2010-05-23

This study established a flow injection (FI) methodology for the determination of the total phenolic content in plant-derived beverages based on soluble manganese(IV) chemiluminescence (CL) detection. It was found that mixing polyphenols with acidic soluble manganese(IV) in the presence of formaldehyde evoked chemiluminescence. Based on this finding, a new FI-CL method was developed for the estimation of the total content of phenolic compounds (expressed as milligrams of gallic acid equivalent per litre of drink) in a variety of wine, tea and fruit juice samples. The proposed method is sensitive with a detection limit of 0.02 ng mL(-1) (gallic acid), offers a wide linear dynamic range (0.5-400 ng mL(-1)) and high sample throughput (247 samples h(-1)). The relative standard deviation for 15 measurements was 3.8% for 2 ng mL(-1) and 0.45% for 10 ng mL(-1) of gallic acid. Analysis of 36 different samples showed that the results obtained by the proposed FI-CL method correlate highly with those obtained by spectrophotometric methods commonly used for the evaluation of the total phenolic/antioxidant level. However, the FI-CL method was found to be far simpler, more rapid and selective, with almost no interference from non-phenolic components of the samples examined. Copyright 2010 Elsevier B.V. All rights reserved.

Needleless connectors substantially reduce flow of crystalloid and red blood cells during rapid infusion.

PubMed

Lehn, Robert A; Gross, Jeffrey B; McIsaac, Joseph H; Gipson, Keith E

2015-04-01

Although needleless connectors (NC) are frequently used in the perioperative setting, the potential of modern NCs to slow delivery of IV fluids has not been thoroughly studied. We examined flow characteristics of 5 NC models during pressurized delivery of crystalloid and banked red blood cells from a Level 1 warmer through various IV catheters. Crystalloid flow rates were reduced by 29% to 85% from control in catheters >18 gauge, while red blood cell flow reductions ranged from 22% to 76% in these catheters (all P < 0.0050). We suggest that practitioners consider eliminating NCs when large IV catheters are inserted for rapid fluid administration.

Living liquid crystals

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhou, S.; Sokolov, A.; Lavrentovich, O. D.

2014-01-13

Collective motion of self-propelled organisms or synthetic par­ticles, often termed •active fluid,• has attracted enormous atten­tion in the broad scientific community because of its fundamentally nonequilibrium nature. Energy input and interactions among the moving units and the medium lead to complex dynamics. Here,we introduce a class of active matter-living liquid crystals (UCs}­ that combines living swimming bacteria with a lyotropic liquid crystal. The physical properties of LLCs can be controlled by the amount of oxygen available to bacteria, by concentration of ingre­dients, or by temperature. Our studies reveal a wealth of intriguing dynamic phenomena. caused by the coupling between themore » activity-triggered flow and long-range orientational order of the medium. Among these are (i) nonlinear trajectories of bacterial motion guided by nonuniform director, (ii) local melting of the liquid crystal caused by the bacteria-produced shear flows, (iii) activity-triggered transition from a nonflowing uniform state into a flowing one-dimensional periodic pattern and its evolution into a turbulent array of topological defects, and (iv) birefringence­ enabled visualization of microflow generated by the nanometers­ thick bacterial flagella. Unlike their isotropic counterpart, the LLCs show collective dynamic effects at very low volume fraction of bacteria, on the order of 0.2%. Our work suggests an unorthodox design concept to control and manipulate the dynamic behavior of soft active matter and opens the door for potential biosensing and biomedical applications.« less

Vortex-slip transitions in superconducting a-NbGe mesoscopic channels

NASA Astrophysics Data System (ADS)

Kokubo, N.; Sorop, T. G.; Besseling, R.; Kes, P. H.

2006-06-01

Intriguing and novel physical aspects related to the vortex flow dynamics have been recently observed in mesoscopic channel devices of a-NbGe with NbN channel edges. In this work we have systematically studied the flow properties of vortices confined in such mesoscopic channels as a function of the magnetic field history, using dc-transport and mode-locking (ML) measurements. As opposed to the field-down situation, in the field-up case a kink anomaly in the dc I-V curves is detected. The mode-locking measurements reveal that this anomaly is, in fact, a flow induced vortex slip transition: by increasing the external drive (either dc or ac) a sudden change occurs from n to n+2 moving vortex rows in the channel. The observed features can be explained in terms of an interplay between field focusing due to screening currents and a change in the predominant pinning mechanism.

Constraints on filament models deduced from dynamical analysis

NASA Technical Reports Server (NTRS)

Simon, G.; Schmieder, B.; Demoulin, P.; Malherbe, J. M.; Poland, A. I.

1986-01-01

The conclusions deduced from simultaneous observations with the Ultra-Violet Spectrometer and Polarimeter (UVSP) on the Solar Maximum Mission satellite, and the Multichannel Subtractive Double Pass (MSPD) spectrographs at Meudon and Pic du Midi observatories are presented. The observations were obtained in 1980 and 1984. All instruments have almost the same field of view and provide intensity and velocity maps at two temperatures. The resolution is approx. 0.5 to 1.5" for H alpha line and 3" for C IV. The high resolution and simultaneity of the two types of observations allows a more accurate description of the flows in prominences as functions of temperature and position. The results put some contraints on the models and show that dynamical aspects must be taken into account.

Proposal for a new classification of variations in the iliac venous system based on internal iliac veins: a case series and a review of double and left inferior vena cava.

PubMed

Hayashi, Shogo; Naito, Munekazu; Hirai, Shuichi; Terayama, Hayato; Miyaki, Takayoshi; Itoh, Masahiro; Fukuzawa, Yoshitaka; Nakano, Takashi

2013-09-01

There are many reports on variations in the inferior vena cava (IVC), particularly double IVC (DIVC) and left IVC (LIVC). However, no systematic report has recorded iliac vein (IV) flow patterns in the DIVC and LIVC. In this study, we examined IV flow patterns in both DIVC and LIVC observed during gross anatomy courses conducted for medical students and in previously reported cases. During the gross anatomy courses, three cases of DIVC and one case of LIVC were found in 618 cadavers. The IV flow pattern from these four cases and all other previously reported cases can be classified into one of the following three types according to the vein into which the internal iliac vein drained: the ipsilateral external IV; confluence of the ipsilateral external IV and IVC; and the communicating vein, which connects the IVC and the contralateral IVC or its iliac branch. This classification, which is based on the internal IV course, is considered to be useful because IV variations have the potential to cause clinical problems during related retroperitoneal surgery, venous interventional radiology, and diagnostic procedures for pelvic cancer.

Syringe Pump Performance Maintained with IV Filter Use During Low Flow Rate Delivery for Pediatric Patients.

PubMed

Chau, Destiny F; Vasilopoulos, Terrie; Schoepf, Miriam; Zhang, Christina; Fahy, Brenda G

2016-09-01

Complex surgical and critically ill pediatric patients rely on syringe infusion pumps for precise delivery of IV medications. Low flow rates and in-line IV filter use may affect drug delivery. To determine the effects of an in-line filter to remove air and/or contaminants on syringe pump performance at low flow rates, we compared the measured rates with the programmed flow rates with and without in-line IV filters. Standardized IV infusion assemblies with and without IV filters (filter and control groups) attached to a 10-mL syringe were primed and then loaded onto a syringe pump and connected to a 16-gauge, 16-cm single-lumen catheter. The catheter was suspended in a normal saline fluid column to simulate the back pressure from central venous circulation. The delivered infusate was measured by gravimetric methods at predetermined time intervals, and flow rate was calculated. Experimental trials for initial programmed rates of 1.0, 0.8, 0.6, and 0.4 mL/h were performed in control and filter groups. For each trial, the flow rate was changed to double the initial flow rate and was then returned to the initial flow rate to analyze pump performance for titration of rates often required during medication administration. These conditions (initial rate, doubling of initial rate, and return to initial rate) were analyzed separately for steady-state flow rate and time to steady state, whereas their average was used for percent deviation analysis. Differences between control and filter groups were assessed using Student t tests with adjustment for multiplicity (using n = 3 replications per group). Mean time from 0 to initial flow (startup delay) was <1 minute in both groups with no statistical difference between groups (P = 1.0). The average time to reach steady-state flow after infusion startup or rate changes was not statistically different between the groups (range, 0.8-5.5 minutes), for any flow rate or part of the trial (initial rate, doubling of initial rate, and return to initial rate), although the study was underpowered to detect small time differences. Overall, the mean steady-state flow rate for each trial was below the programmed flow rate with negative mean percent deviations for each trial. In the 1.0-mL/h initial rate trial, the steady-state flow rate attained was lower in the filter than the control group for the initial rate (P = 0.04) and doubling of initial rate (P = 0.04) with a trend during the return to initial rate (P = 0.06), although this same effect was not observed when doubling the initial rate trials of 0.8 or 0.6 mL/h or any other rate trials compared with the control group. With low flow rates used in complex surgical and pediatric critically ill patients, the addition of IV filters did not confer statistically significant changes in startup delay, flow variability, or time to reach steady-state flow of medications administered by syringe infusion pumps. The overall flow rate was lower than programmed flow rate with or without a filter.

A unified gas-kinetic scheme for continuum and rarefied flows IV: Full Boltzmann and model equations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Chang, E-mail: cliuaa@ust.hk; Xu, Kun, E-mail: makxu@ust.hk; Sun, Quanhua, E-mail: qsun@imech.ac.cn

Fluid dynamic equations are valid in their respective modeling scales, such as the particle mean free path scale of the Boltzmann equation and the hydrodynamic scale of the Navier–Stokes (NS) equations. With a variation of the modeling scales, theoretically there should have a continuous spectrum of fluid dynamic equations. Even though the Boltzmann equation is claimed to be valid in all scales, many Boltzmann solvers, including direct simulation Monte Carlo method, require the cell resolution to the order of particle mean free path scale. Therefore, they are still single scale methods. In order to study multiscale flow evolution efficiently, themore » dynamics in the computational fluid has to be changed with the scales. A direct modeling of flow physics with a changeable scale may become an appropriate approach. The unified gas-kinetic scheme (UGKS) is a direct modeling method in the mesh size scale, and its underlying flow physics depends on the resolution of the cell size relative to the particle mean free path. The cell size of UGKS is not limited by the particle mean free path. With the variation of the ratio between the numerical cell size and local particle mean free path, the UGKS recovers the flow dynamics from the particle transport and collision in the kinetic scale to the wave propagation in the hydrodynamic scale. The previous UGKS is mostly constructed from the evolution solution of kinetic model equations. Even though the UGKS is very accurate and effective in the low transition and continuum flow regimes with the time step being much larger than the particle mean free time, it still has space to develop more accurate flow solver in the region, where the time step is comparable with the local particle mean free time. In such a scale, there is dynamic difference from the full Boltzmann collision term and the model equations. This work is about the further development of the UGKS with the implementation of the full Boltzmann collision term in the region where it is needed. The central ingredient of the UGKS is the coupled treatment of particle transport and collision in the flux evaluation across a cell interface, where a continuous flow dynamics from kinetic to hydrodynamic scales is modeled. The newly developed UGKS has the asymptotic preserving (AP) property of recovering the NS solutions in the continuum flow regime, and the full Boltzmann solution in the rarefied regime. In the mostly unexplored transition regime, the UGKS itself provides a valuable tool for the non-equilibrium flow study. The mathematical properties of the scheme, such as stability, accuracy, and the asymptotic preserving, will be analyzed in this paper as well.« less

Effects of lornoxicam and intravenous ibuprofen on erythrocyte deformability and hepatic and renal blood flow in rats.

PubMed

Arpacı, Hande; Çomu, Faruk Metin; Küçük, Ayşegül; Kösem, Bahadır; Kartal, Seyfi; Şıvgın, Volkan; Turgut, Hüseyin Cihad; Aydın, Muhammed Enes; Koç, Derya Sebile; Arslan, Mustafa

2016-01-01

Change in blood supply is held responsible for anesthesia-related abnormal tissue and organ perfusion. Decreased erythrocyte deformability and increased aggregation may be detected after surgery performed under general anesthesia. It was shown that nonsteroidal anti-inflammatory drugs decrease erythrocyte deformability. Lornoxicam and/or intravenous (iv) ibuprofen are commonly preferred analgesic agents for postoperative pain management. In this study, we aimed to investigate the effects of lornoxicam (2 mg/kg, iv) and ibuprofen (30 mg/kg, iv) on erythrocyte deformability, as well as hepatic and renal blood flows, in male rats. Eighteen male Wistar albino rats were randomly divided into three groups as follows: iv lornoxicam-treated group (Group L), iv ibuprofen-treated group (Group İ), and control group (Group C). Drug administration was carried out by the iv route in all groups except Group C. Hepatic and renal blood flows were studied by laser Doppler, and euthanasia was performed via intra-abdominal blood uptake. Erythrocyte deformability was measured using a constant-flow filtrometry system. Lornoxicam and ibuprofen increased the relative resistance, which is an indicator of erythrocyte deformability, of rats (P=0.016). Comparison of the results from Group L and Group I revealed no statistically significant differences (P=0.694), although the erythrocyte deformability levels in Group L and Group I were statistically higher than the results observed in Group C (P=0.018 and P=0.008, respectively). Hepatic and renal blood flows were significantly lower than the same in Group C. We believe that lornoxicam and ibuprofen may lead to functional disorders related to renal and liver tissue perfusion secondary to both decreased blood flow and erythrocyte deformability. Further studies regarding these issues are thought to be essential.

Impact of climate change on freshwater resources in a heterogeneous coastal aquifer of Bremerhaven, Germany: A three-dimensional modeling study.

PubMed

Yang, Jie; Graf, Thomas; Ptak, Thomas

2015-01-01

Climate change is expected to induce sea level rise in the German Bight, which is part of the North Sea, Germany. Climate change may also modify river discharge of the river Weser flowing into the German Bight, which will alter both pressure and salinity distributions in the river Weser estuary. To study the long-term interaction between sea level rise, discharge variations, a storm surge and coastal aquifer flow dynamics, a 3D seawater intrusion model was designed using the fully coupled surface-subsurface numerical model HydroGeoSphere. The model simulates the coastal aquifer as an integral system considering complexities such as variable-density flow, variably saturated flow, irregular boundary conditions, irregular land surface and anthropogenic structures (e.g., dyke, drainage canals, water gates). The simulated steady-state groundwater flow of the year 2009 is calibrated using PEST. In addition, four climate change scenarios are simulated based on the calibrated model: (i) sea level rise of 1m, (ii) the salinity of the seaside boundary increases by 4 PSU (Practical Salinity Units), (iii) the salinity of the seaside boundary decreases by 12 PSU, and (iv) a storm surge with partial dyke failure. Under scenarios (i) and (iv), the salinized area expands several kilometers further inland during several years. Natural remediation can take up to 20 years. However, sudden short-term salinity changes in the river Weser estuary do not influence the salinized area in the coastal aquifer. The obtained results are useful for coastal engineering practices and drinking water resource management. Copyright © 2015 Elsevier B.V. All rights reserved.

Secondary flow structures in the presence of Type-IV stent fractures through a bent tube model for curved arteries: Effect of circulation thresholding

NASA Astrophysics Data System (ADS)

Hussain, Shadman; Bulusu, Kartik V.; Plesniak, Michael W.

2013-11-01

A common treatment for atherosclerosis is the opening of narrowed arteries resulting from obstructive lesions by angioplasty and stent implantation to restore unrestricted blood flow. ``Type-IV'' stent fractures involve complete transverse, linear fracture of stent struts, along with displacement of the stent fragments. Experimental data pertaining to secondary flows in the presence of stents that underwent ``Type-IV'' fractures in a bent artery model under physiological inflow conditions were obtained through a two-component, two-dimensional (2C-2D) PIV technique. Concomitant stent-induced flow perturbations result in secondary flow structures with complex, multi-scale morphologies and varying size-strength characteristics. Ultimately, these flow structures may have a role to play in restenosis and progression of atherosclerotic plaque. Vortex circulation thresholds were established with the goal of resolving and tracking iso-circulation secondary flow vortical structures and their morphological changes. This allowed for a parametric evaluation and quantitative representation of secondary flow structures undergoing deformation and spatial reorganization. Supported by NSF Grant No. CBET- 0828903 and GW Center for Biomimetics and Bioinspired Engineering.

Coupled Modeling of Rhizosphere and Reactive Transport Processes

NASA Astrophysics Data System (ADS)

Roque-Malo, S.; Kumar, P.

2017-12-01

The rhizosphere, as a bio-diverse plant root-soil interface, hosts many hydrologic and biochemical processes, including nutrient cycling, hydraulic redistribution, and soil carbon dynamics among others. The biogeochemical function of root networks, including the facilitation of nutrient cycling through absorption and rhizodeposition, interaction with micro-organisms and fungi, contribution to biomass, etc., plays an important role in myriad Critical Zone processes. Despite this knowledge, the role of the rhizosphere on watershed-scale ecohydrologic functions in the Critical Zone has not been fully characterized, and specifically, the extensive capabilities of reactive transport models (RTMs) have not been applied to these hydrobiogeochemical dynamics. This study uniquely links rhizospheric processes with reactive transport modeling to couple soil biogeochemistry, biological processes, hydrologic flow, hydraulic redistribution, and vegetation dynamics. Key factors in the novel modeling approach are: (i) bi-directional effects of root-soil interaction, such as simultaneous root exudation and nutrient absorption; (ii) multi-state biomass fractions in soil (i.e. living, dormant, and dead biological and root materials); (iii) expression of three-dimensional fluxes to represent both vertical and lateral interconnected flows and processes; and (iv) the potential to include the influence of non-stationary external forcing and climatic factors. We anticipate that the resulting model will demonstrate the extensive effects of plant root dynamics on ecohydrologic functions at the watershed scale and will ultimately contribute to a better characterization of efflux from both agricultural and natural systems.

Infusion volume control and calculation using metronome and drop counter based intravenous infusion therapy helper.

PubMed

Park, Kyungnam; Lee, Jangyoung; Kim, Soo-Young; Kim, Jinwoo; Kim, Insoo; Choi, Seung Pill; Jeong, Sikyung; Hong, Sungyoup

2013-06-01

This study assessed the method of fluid infusion control using an IntraVenous Infusion Controller (IVIC). Four methods of infusion control (dial flow controller, IV set without correction, IV set with correction and IVIC correction) were used to measure the volume of each technique at two infusion rates. The infused fluid volume with a dial flow controller was significantly larger than other methods. The infused fluid volume was significantly smaller with an IV set without correction over time. Regarding the concordance correlation coefficient (CCC) of infused fluid volume in relation to a target volume, IVIC correction was shown to have the highest level of agreement. The flow rate measured in check mode showed a good agreement with the volume of collected fluid after passing through the IV system. Thus, an IVIC could assist in providing an accurate infusion control. © 2013 Wiley Publishing Asia Pty Ltd.

ALI: A CSSL/multiprocessor software interface

DOE Office of Scientific and Technical Information (OSTI.GOV)

Makoui, A.; Karplus, W.J.

ALI (A Language Interface) is a software package which translates simulation models expressed in one of the higher-level languages, CSSL-IV or ACSL, into sequences of instructions for each processor of a network of microprocessors. The partitioning of the source program among the processors is automatically accomplished. The code is converted into a data flow graph, analyzed and divided among the processors to minimize the overall execution time in the presence of interprocessor communication delays. This paper describes ALI from the user's point of view and includes a detailed example of the application of ALI to a specific dynamic system simulation.

ON THE CONNECTION BETWEEN PROPAGATING SOLAR CORONAL DISTURBANCES AND CHROMOSPHERIC FOOTPOINTS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bryans, P.; McIntosh, S. W.; Moortel, I. De

2016-09-20

The Interface Region Imaging Spectrograph ( IRIS ) provides an unparalleled opportunity to explore the (thermal) interface between the chromosphere, transition region, and the coronal plasma observed by the Atmospheric Imaging Assembly (AIA) of the Solar Dynamics Observatory ( SDO ). The SDO /AIA observations of coronal loop footpoints show strong recurring upward propagating signals—“propagating coronal disturbances” (PCDs) with apparent speeds of the order of 100–120 km s{sup −1}. That signal has a clear signature in the slit-jaw images of IRIS in addition to identifiable spectral signatures and diagnostics in the Mg iih (2803 Å) line. In analyzing the Mgmore » iih line, we are able to observe the presence of magnetoacoustic shock waves that are also present in the vicinity of the coronal loop footpoints. We see there is enough of a correspondence between the shock propagation in Mg iih, the evolution of the Si iv line profiles, and the PCD evolution to indicate that these waves are an important ingredient for PCDs. In addition, the strong flows in the jet-like features in the IRIS Si iv slit-jaw images are also associated with PCDs, such that waves and flows both appear to be contributing to the signals observed at the footpoints of PCDs.« less

An efficient finite differences method for the computation of compressible, subsonic, unsteady flows past airfoils and panels

NASA Astrophysics Data System (ADS)

Colera, Manuel; Pérez-Saborid, Miguel

2017-09-01

A finite differences scheme is proposed in this work to compute in the time domain the compressible, subsonic, unsteady flow past an aerodynamic airfoil using the linearized potential theory. It improves and extends the original method proposed in this journal by Hariharan, Ping and Scott [1] by considering: (i) a non-uniform mesh, (ii) an implicit time integration algorithm, (iii) a vectorized implementation and (iv) the coupled airfoil dynamics and fluid dynamic loads. First, we have formulated the method for cases in which the airfoil motion is given. The scheme has been tested on well known problems in unsteady aerodynamics -such as the response to a sudden change of the angle of attack and to a harmonic motion of the airfoil- and has been proved to be more accurate and efficient than other finite differences and vortex-lattice methods found in the literature. Secondly, we have coupled our method to the equations governing the airfoil dynamics in order to numerically solve problems where the airfoil motion is unknown a priori as happens, for example, in the cases of the flutter and the divergence of a typical section of a wing or of a flexible panel. Apparently, this is the first self-consistent and easy-to-implement numerical analysis in the time domain of the compressible, linearized coupled dynamics of the (generally flexible) airfoil-fluid system carried out in the literature. The results for the particular case of a rigid airfoil show excellent agreement with those reported by other authors, whereas those obtained for the case of a cantilevered flexible airfoil in compressible flow seem to be original or, at least, not well-known.

Probabilistic Evaluation of Anthropogenic Regulations In a Vegetated River Channel Using a Vegetation Dynamics Modeling

NASA Astrophysics Data System (ADS)

Miyamoto, Hitoshi

2015-04-01

Vegetation overgrowth in fluvial floodplains, gravel beds, and sand bars has been a serious engineering problem for riparian management in Japan. From the viewpoints of flood control and ecological conservation, it would be necessary to predict the vegetation dynamics accurately for long-term duration. In this research, we have developed a stochastic model for predicting the vegetation dynamics in fluvial floodplains with emphasis on the interaction with flood impacts. The model consists of the following four components: (i) long-term stochastic behavior of flow discharge, (ii) hydrodynamics in a channel with floodplain vegetation, (iii) variation of riverbed topography, and (iv) vegetation dynamics on floodplains. In the vegetation dynamics model, the flood discharge (i) is stochastically simulated using a filtered Poisson process, one of the conventional approaches in hydrological time-series generation. The component for vegetation dynamics (iv) includes the effects of tree growth, mortality by floods, and infant tree recruitment. Vegetation condition has been observed mainly before and after floods since 2008 at a field site located between 23-24 km from the river mouth in Kako River, Japan. The Kako River has the catchment area of 1,730 km2 and the main channel length of 96 km. This site is one of the vegetation overgrowth sites in the Kako River floodplains. The predominant tree species are willows and bamboos. In the field survey, the position, trunk diameter and height of each tree as well as the riverbed materials were measured after several flood events to investigate their impacts on the floodplain vegetation community. This presentation tries to examine effects of anthropogenic river regulations, i.e., thinning and cutting-down, in the vegetated channel in Kako River by using the vegetation dynamics model. Sensitivity of both the flood water level and the vegetation status in the channel is statistically evaluated in terms of the different cutting-down levels, timings and scales of the thinning, etc., by the Monte Carlo simulation of the model.

Implicit mesh discontinuous Galerkin methods and interfacial gauge methods for high-order accurate interface dynamics, with applications to surface tension dynamics, rigid body fluid-structure interaction, and free surface flow: Part I

NASA Astrophysics Data System (ADS)

Saye, Robert

2017-09-01

In this two-part paper, a high-order accurate implicit mesh discontinuous Galerkin (dG) framework is developed for fluid interface dynamics, facilitating precise computation of interfacial fluid flow in evolving geometries. The framework uses implicitly defined meshes-wherein a reference quadtree or octree grid is combined with an implicit representation of evolving interfaces and moving domain boundaries-and allows physically prescribed interfacial jump conditions to be imposed or captured with high-order accuracy. Part one discusses the design of the framework, including: (i) high-order quadrature for implicitly defined elements and faces; (ii) high-order accurate discretisation of scalar and vector-valued elliptic partial differential equations with interfacial jumps in ellipticity coefficient, leading to optimal-order accuracy in the maximum norm and discrete linear systems that are symmetric positive (semi)definite; (iii) the design of incompressible fluid flow projection operators, which except for the influence of small penalty parameters, are discretely idempotent; and (iv) the design of geometric multigrid methods for elliptic interface problems on implicitly defined meshes and their use as preconditioners for the conjugate gradient method. Also discussed is a variety of aspects relating to moving interfaces, including: (v) dG discretisations of the level set method on implicitly defined meshes; (vi) transferring state between evolving implicit meshes; (vii) preserving mesh topology to accurately compute temporal derivatives; (viii) high-order accurate reinitialisation of level set functions; and (ix) the integration of adaptive mesh refinement. In part two, several applications of the implicit mesh dG framework in two and three dimensions are presented, including examples of single phase flow in nontrivial geometry, surface tension-driven two phase flow with phase-dependent fluid density and viscosity, rigid body fluid-structure interaction, and free surface flow. A class of techniques known as interfacial gauge methods is adopted to solve the corresponding incompressible Navier-Stokes equations, which, compared to archetypical projection methods, have a weaker coupling between fluid velocity, pressure, and interface position, and allow high-order accurate numerical methods to be developed more easily. Convergence analyses conducted throughout the work demonstrate high-order accuracy in the maximum norm for all of the applications considered; for example, fourth-order spatial accuracy in fluid velocity, pressure, and interface location is demonstrated for surface tension-driven two phase flow in 2D and 3D. Specific application examples include: vortex shedding in nontrivial geometry, capillary wave dynamics revealing fine-scale flow features, falling rigid bodies tumbling in unsteady flow, and free surface flow over a submersed obstacle, as well as high Reynolds number soap bubble oscillation dynamics and vortex shedding induced by a type of Plateau-Rayleigh instability in water ripple free surface flow. These last two examples compare numerical results with experimental data and serve as an additional means of validation; they also reveal physical phenomena not visible in the experiments, highlight how small-scale interfacial features develop and affect macroscopic dynamics, and demonstrate the wide range of spatial scales often at play in interfacial fluid flow.

Implicit mesh discontinuous Galerkin methods and interfacial gauge methods for high-order accurate interface dynamics, with applications to surface tension dynamics, rigid body fluid-structure interaction, and free surface flow: Part II

NASA Astrophysics Data System (ADS)

Saye, Robert

2017-09-01

In this two-part paper, a high-order accurate implicit mesh discontinuous Galerkin (dG) framework is developed for fluid interface dynamics, facilitating precise computation of interfacial fluid flow in evolving geometries. The framework uses implicitly defined meshes-wherein a reference quadtree or octree grid is combined with an implicit representation of evolving interfaces and moving domain boundaries-and allows physically prescribed interfacial jump conditions to be imposed or captured with high-order accuracy. Part one discusses the design of the framework, including: (i) high-order quadrature for implicitly defined elements and faces; (ii) high-order accurate discretisation of scalar and vector-valued elliptic partial differential equations with interfacial jumps in ellipticity coefficient, leading to optimal-order accuracy in the maximum norm and discrete linear systems that are symmetric positive (semi)definite; (iii) the design of incompressible fluid flow projection operators, which except for the influence of small penalty parameters, are discretely idempotent; and (iv) the design of geometric multigrid methods for elliptic interface problems on implicitly defined meshes and their use as preconditioners for the conjugate gradient method. Also discussed is a variety of aspects relating to moving interfaces, including: (v) dG discretisations of the level set method on implicitly defined meshes; (vi) transferring state between evolving implicit meshes; (vii) preserving mesh topology to accurately compute temporal derivatives; (viii) high-order accurate reinitialisation of level set functions; and (ix) the integration of adaptive mesh refinement. In part two, several applications of the implicit mesh dG framework in two and three dimensions are presented, including examples of single phase flow in nontrivial geometry, surface tension-driven two phase flow with phase-dependent fluid density and viscosity, rigid body fluid-structure interaction, and free surface flow. A class of techniques known as interfacial gauge methods is adopted to solve the corresponding incompressible Navier-Stokes equations, which, compared to archetypical projection methods, have a weaker coupling between fluid velocity, pressure, and interface position, and allow high-order accurate numerical methods to be developed more easily. Convergence analyses conducted throughout the work demonstrate high-order accuracy in the maximum norm for all of the applications considered; for example, fourth-order spatial accuracy in fluid velocity, pressure, and interface location is demonstrated for surface tension-driven two phase flow in 2D and 3D. Specific application examples include: vortex shedding in nontrivial geometry, capillary wave dynamics revealing fine-scale flow features, falling rigid bodies tumbling in unsteady flow, and free surface flow over a submersed obstacle, as well as high Reynolds number soap bubble oscillation dynamics and vortex shedding induced by a type of Plateau-Rayleigh instability in water ripple free surface flow. These last two examples compare numerical results with experimental data and serve as an additional means of validation; they also reveal physical phenomena not visible in the experiments, highlight how small-scale interfacial features develop and affect macroscopic dynamics, and demonstrate the wide range of spatial scales often at play in interfacial fluid flow.

Development of a Model for Dynamic Recrystallization Consistent with the Second Derivative Criterion.

PubMed

Imran, Muhammad; Kühbach, Markus; Roters, Franz; Bambach, Markus

2017-11-02

Dynamic recrystallization (DRX) processes are widely used in industrial hot working operations, not only to keep the forming forces low but also to control the microstructure and final properties of the workpiece. According to the second derivative criterion (SDC) by Poliak and Jonas, the onset of DRX can be detected from an inflection point in the strain-hardening rate as a function of flow stress. Various models are available that can predict the evolution of flow stress from incipient plastic flow up to steady-state deformation in the presence of DRX. Some of these models have been implemented into finite element codes and are widely used for the design of metal forming processes, but their consistency with the SDC has not been investigated. This work identifies three sources of inconsistencies that models for DRX may exhibit. For a consistent modeling of the DRX kinetics, a new strain-hardening model for the hardening stages III to IV is proposed and combined with consistent recrystallization kinetics. The model is devised in the Kocks-Mecking space based on characteristic transition in the strain-hardening rate. A linear variation of the transition and inflection points is observed for alloy 800H at all tested temperatures and strain rates. The comparison of experimental and model results shows that the model is able to follow the course of the strain-hardening rate very precisely, such that highly accurate flow stress predictions are obtained.

Development of a Model for Dynamic Recrystallization Consistent with the Second Derivative Criterion

PubMed Central

Imran, Muhammad; Kühbach, Markus; Roters, Franz; Bambach, Markus

2017-01-01

Dynamic recrystallization (DRX) processes are widely used in industrial hot working operations, not only to keep the forming forces low but also to control the microstructure and final properties of the workpiece. According to the second derivative criterion (SDC) by Poliak and Jonas, the onset of DRX can be detected from an inflection point in the strain-hardening rate as a function of flow stress. Various models are available that can predict the evolution of flow stress from incipient plastic flow up to steady-state deformation in the presence of DRX. Some of these models have been implemented into finite element codes and are widely used for the design of metal forming processes, but their consistency with the SDC has not been investigated. This work identifies three sources of inconsistencies that models for DRX may exhibit. For a consistent modeling of the DRX kinetics, a new strain-hardening model for the hardening stages III to IV is proposed and combined with consistent recrystallization kinetics. The model is devised in the Kocks-Mecking space based on characteristic transition in the strain-hardening rate. A linear variation of the transition and inflection points is observed for alloy 800H at all tested temperatures and strain rates. The comparison of experimental and model results shows that the model is able to follow the course of the strain-hardening rate very precisely, such that highly accurate flow stress predictions are obtained. PMID:29099068

Flow injection for the determination of Se(IV) and Se(VI) by hydride generation atomic absorption spectrometry with microwave oven on-line prereduction of Se(VI) to Se(IV)

NASA Astrophysics Data System (ADS)

Burguera, J. L.; Carrero, P.; Burguera, M.; Rondon, C.; Brunetto, M. R.; Gallignani, M.

1996-12-01

An on-line flow injection system has been developed for the selective determination of Se(IV) and Se(VI) in citric fruit juices and geothermal waters by hydride generation atomic absorption spectrometry with microwave-aided heating prereduction of Se(VI) to Se(IV). The samples and the prereductant solutions (4 mol l -1 HCl for Se(IV) and 12 mol l -1 HCl for Se(VI)) which circulated in a closed-flow circuit were injected by means of a time-based injector. This mixture was displaced by a carrier solution of 1% v/v of hydrochloric acid through a PTFE coil located inside the focused microwave oven and mixed downstream with a borohydride solution to generate the hydride. The linear ranges were 0-120 and 0-100 μg l -1 of Se(IV) and Se(VI), respectively. The detection limits were 1.0 μg l -1 for Se(IV) and 1.5 μg l -1 for Se(VI). The precision (about 2.0-2.5% RSD) and recoveries (96-98% for Se(IV) and 94-98% for Se(VI)) were good. Total selenium values were also obtained by electrothermal atomic absorption spectrometry which agreed with the content of both selenium species. The sample throughput was about 50 measurements per hour. The main advantage of the method is that the selective determination of Se(IV) and Se(VI) in citric fruit juices and geothermal waters is performed in a closed system with a minimum sample manipulation, exposure to the environment, minimum sample waste and operator attention.

Features of current-voltage characteristic of nonequilibrium trench MOS barrier Schottky diode

NASA Astrophysics Data System (ADS)

Mamedov, R. K.; Aslanova, A. R.

2018-06-01

The trench MOS barrier Schottky diodes (TMBS diode) under the influence of the voltage drop of the additional electric field (AEF) appearing in the near-contact region of the semiconductor are in a nonequilibrium state and their closed external circuit flows currents in the absence of an external voltage. When an external voltage is applied to the TMBS diode, the current transmission is described by the thermionic emission theory with a specific feature. Both forward and reverse I-V characteristics of the TMBS diode consist of two parts. In the initial first part of the forward I-V characteristic there are no forward currents, but reverse saturation currents flow, in its subsequent second part the currents increase exponentially with the voltage. In the initial first part of the reverse I-V characteristic, the currents increase in an abrupt way and in the subsequent second part the saturation currents flow under the action of the image force. The mathematical expressions for forward and reverse I-V characteristic of the TMBS diode and also narrow or nanostructure Schottky diode are proposed, which are in good agreement with the results of experimental and calculated I-V characteristics.

In vitro quantitative ((1))H and ((19))F nuclear magnetic resonance spectroscopy and imaging studies of fluvastatin™ in Lescol® XL tablets in a USP-IV dissolution cell.

PubMed

Zhang, Qilei; Gladden, Lynn; Avalle, Paolo; Mantle, Michael

2011-12-20

Swellable polymeric matrices are key systems in the controlled drug release area. Currently, the vast majority of research is still focused on polymer swelling dynamics. This study represents the first quantitative multi-nuclear (((1))H and ((19))F) fast magnetic resonance imaging study of the complete dissolution process of a commercial (Lescol® XL) tablet, whose formulation is based on the hydroxypropyl methylcellulose (HPMC) polymer under in vitro conditions in a standard USP-IV (United States Pharmacopeia apparatus IV) flow-through cell that is incorporated into high field superconducting magnetic resonance spectrometer. Quantitative RARE ((1))H magnetic resonance imaging (MRI) and ((19))F nuclear magnetic resonance (NMR) spectroscopy and imaging methods have been used to give information on: (i) dissolution media uptake and hydrodynamics; (ii) active pharmaceutical ingredient (API) mobilisation and dissolution; (iii) matrix swelling and dissolution and (iv) media activity within the swelling matrix. In order to better reflect the in vivo conditions, the bio-relevant media Simulated Gastric Fluid (SGF) and Fasted State Simulated Intestinal Fluid (FaSSIF) were used. A newly developed quantitative ultra-fast MRI technique was applied and the results clearly show the transport dynamics of media penetration and hydrodynamics along with the polymer swelling processes. The drug dissolution and mobility inside the gel matrix was characterised, in parallel to the ((1))H measurements, by ((19))F NMR spectroscopy and MRI, and the drug release profile in the bulk solution was recorded offline by UV spectrometer. We found that NMR spectroscopy and 1D-MRI can be uniquely used to monitor the drug dissolution/mobilisation process within the gel layer, and the results from ((19))F NMR spectra indicate that in the gel layer, the physical mobility of the drug changes from "dissolved immobilised drug" to "dissolved mobilised drug". Copyright © 2011 Elsevier B.V. All rights reserved.

A flow method based on solvent extraction coupled on-line to a reversed micellar mediated chemiluminescence detection for selective determination of gold(III) and gallium(III) in water and industrial samples.

PubMed

Hasanin, Tamer H A; Okamoto, Yasuaki; Fujiwara, Terufumi

2016-02-01

A rapid and sensitive flow method, based on the combination of on-line solvent extraction with reversed micellar mediated chemiluminescence (CL) detection using rhodamine B (RB), was investigated for the selective determination of Au(III) and Ga(III) in aqueous solutions. 2.0 M HCl was the optimum for extracting Au(III) while a 5.0M HCl solution containing 2.5M LiCl was selected as an optimum acidic medium for extraction of Ga(III). The Au(III) and Ga(III) chloro-complex anions were extracted from the above aqueous acidic solutions into toluene as their ion-pair complexes with the protonated RBH(+) ion followed by membrane phase separation in a flow system. In a flow cell of a detector, the extract was mixed with the reversed micellar solution of cetyltrimethylammonium chloride (CTAC) in 1-hexanol-cyclohexane/water (1.0M HCl) containing 0.10 M cerium(IV) and 0.05 M lithium sulfate. Then uptake of the ion-pair by the CTAC reversed micelles and the subsequent CL oxidation of RB with Ce(IV) occurred easily and the CL signals produced were recorded. Using a flow injection system, a detection limit (DL) of 0.4 μM Au(III) and 0.6 μM Ga(III), and linear calibration graphs with dynamic ranges from the respective DLs to 10 μM for Au(III) and Ga(III) were obtained under the optimized experimental conditions. The relative standard deviations (n=6) obtained at 2.0 µM Au(III) and 4.0 µM Ga(III) were 3.0% and 2.4%, respectively. The presented CL methodology has been applied for the determination of Au(III) and Ga(III) in water and industrial samples with satisfactory results. Copyright © 2015 Elsevier B.V. All rights reserved.

Intensification of sodium hydroxide pretreatment of corn stalk using magnetic field in a fluidic system.

PubMed

Jin, Yamei; Yang, Na; Tong, Qunyi; Jin, Zhengyu; Xu, Xueming

2016-11-01

To promote NaOH pretreatment of corn stalk (CS), a continuous processing system uniting magnetic field and millimeter-scaled channel flow was established. First, four comparative pretreatments were conducted: (I) CS was pretreated with NaOH under traditional agitation; (II) CS was pretreated with NaOH in a flowing state inside the millimeter-scaled channel; (III) CS was pretreated with NaOH in a flowing state and under a static magnetic field; or (IV) CS was pretreated with NaOH in a flowing state and under a rotating magnetic field. By comparison, the highest pentose (121.22mg/g dry CS) and hexose (287.04mg/g dry CS) yields were obtained in the shortest pretreatment time with Pretreatment IV (8h). Accordingly, the key parameters of Pretreatment IV were optimized as 6.71Hz frequency, 0.50L/min flow rate, and 1.02% NaOH concentration. Under these conditions, 439.24mg sugars were released by 1g dry CS during pretreatment and enzymatic hydrolysis. Copyright © 2016 Elsevier Ltd. All rights reserved.

DYNAMIC CEREBROVASCULAR AND INTRACRANIAL PRESSURE REACTIVITY ASSESMENT OF IMPAIRED CEREBROVASCULAR AUTOREGULATION IN INTRACRANIAL HYPERTENSION

PubMed Central

Bragin, Denis E.; Statom, Gloria; Nemoto, Edwin M.

2016-01-01

SUMMARY We previously suggested that the discrepancy between the critical cerebral perfusion pressures (CPP) of 30 mmHg, obtained by increasing intracranial pressure (ICP), and 60 mmHg, obtained by decreasing arterial pressure, was due to pathological microvascular shunting at high ICP [1] and that the determination of the critical CPP by the static cerebral blood flow (CBF) autoregulation curve is not valid with intracranial hypertension. Here we demonstrated that critical CPP, measured by induced dynamic ICP reactivity (iPRx) and cerebrovascular reactivity (CVRx), accurately identifies the critical CPP in the hypertensive rat brain which differs from that obtained by the static autoregulation curve. Step changes in CPP from 70 to 50 and 30 mmHg were made by increasing ICP using an artificial cerebrospinal fluid reservoir connected to the cisterna magna. At each CPP, a transient 10-mmHg rise in arterial pressure was induced by bolus i.v. dopamine. iPRx and iCVRx were calculated as ΔICP/ΔMAP and as ΔCBF/ΔMAP, respectively. The critical CPP at high ICP, obtained by iPRx and iCVRx, is 50 mmHg, where compromised capillary flow, transition of blood flow to non-nutritive microvascular shunts, tissue hypoxia and BBB leakage begin to occur, which is higher than the 30 mmHg determined by static autoregulation. PMID:27165917

Dynamic analysis of the urban-based low-carbon policy using system dynamics: Focused on housing and green space

NASA Astrophysics Data System (ADS)

Hong, Taehoon; Kim, Jimin; Koo, Choongwan; Jeong, Kwangbok

2015-02-01

To systematically manage the energy consumption of existing buildings, the government has to enforce greenhouse gas reduction policies. However, most of the policies are not properly executed because they do not consider various factors from the urban level perspective. Therefore, this study aimed to conduct a dynamic analysis of an urban-based low-carbon policy using system dynamics, with a specific focus on housing and green space. This study was conducted in the following steps: (i) establishing the variables of urban-based greenhouse gases (GHGs) emissions; (ii) creating a stock/flow diagram of urban-based GHGs emissions; (iii) conducting an information analysis using the system dynamics; and (iv) proposing the urban-based low-carbon policy. If a combined energy policy that uses the housing sector (30%) and the green space sector (30%) at the same time is implemented, 2020 CO2 emissions will be 7.23 million tons (i.e., 30.48% below 2020 business-as-usual), achieving the national carbon emissions reduction target (26.9%). The results of this study could contribute to managing and improving the fundamentals of the urban-based low-carbon policies to reduce greenhouse gas emissions.

Effects of Flow and Non-Newtonian Fluids on Nonspherical Cavitation Bubbles,

DTIC Science & Technology

1983-04-10

54 10 Alteration of Streamlines by Sphere for Y2 (8.*). 55 11 Major Components of Optical Cavitation. 61 12 Arrangement of Apparatus. 62 13 Laser ...341small" expansion parameter 111.12 Cnj C external flow time constant (t -c 0) WAS1 o spherical coordinate cone angle a f laser focal angle Figure 13...11.2 Dj - D external flow variable IV.22 Dbeam effective laser beau diameter V.1 De Deborah number Table 5 Ce, e, , e strain rates IV.8-9 Or* •e

CFD Analysis of Upper Plenum Flow for a Sodium-Cooled Small Modular Reactor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kraus, A.; Hu, R.

2015-01-01

Upper plenum flow behavior is important for many operational and safety issues in sodium fast reactors. The Prototype Gen-IV Sodium Fast Reactor (PGSFR), a pool-type, 150 MWe output power design, was used as a reference case for a detailed characterization of upper plenum flow for normal operating conditions. Computational Fluid Dynamics (CFD) simulation was utilized with detailed geometric modeling of major structures. Core outlet conditions based on prior system-level calculations were mapped to approximate the outlet temperatures and flow rates for each core assembly. Core outlet flow was found to largely bypass the Upper Internal Structures (UIS). Flow curves overmore » the shield and circulates within the pool before exiting the plenum. Cross-flows and temperatures were evaluated near the core outlet, leading to a proposed height for the core outlet thermocouples to ensure accurate assembly-specific temperature readings. A passive scalar was used to evaluate fluid residence time from core outlet to IHX inlet, which can be used to assess the applicability of various methods for monitoring fuel failure. Additionally, the gas entrainment likelihood was assessed based on the CFD simulation results. Based on the evaluation of velocity gradients and turbulent kinetic energies and the available gas entrainment criteria in the literature, it was concluded that significant gas entrainment is unlikely for the current PGSFR design.« less

Simultaneous leaching of arsenite, arsenate, selenite and selenate, and their migration in tunnel-excavated sedimentary rocks: II. Kinetic and reactive transport modeling.

PubMed

Tabelin, Carlito Baltazar; Sasaki, Ryosuke; Igarashi, Toshifumi; Park, Ilhwan; Tamoto, Shuichi; Arima, Takahiko; Ito, Mayumi; Hiroyoshi, Naoki

2017-12-01

Predicting the fates of arsenic (As) and selenium (Se) in natural geologic media like rocks and soils necessitates the understanding of how their various oxyanionic species behave and migrate under dynamic conditions. In this study, geochemical factors and processes crucial in the leaching and transport of arsenite (As III ), arsenate (As V ), selenite (Se IV ) and selenate (Se VI ) in tunnel-excavated rocks of marine origin were investigated using microscopic/extraction techniques, column experiments, dissolution-precipitation kinetics and one-dimensional reactive transport modeling. The results showed that evaporite salts were important because aside from containing As and Se, they played crucial roles in the evolution of pH and concentrations of coexisting ions, both of which had strong effects on adsorption-desorption reactions of As and Se species with iron oxyhydroxide minerals/phases. The observed leaching trends of As V , As III , Se IV and Se VI were satisfactorily simulated by one-dimensional reactive transport models, which predict that preferential adsorptions of As V and Se IV were magnified by geochemical changes in the columns due to water flow. Moreover, our results showed that migrations of As III , Se IV and Se VI could be predicted adequately by 1D solute transport with simple activity-K' d approach, but surface complexation was more reliable to simulate adsorption-desorption behavior of As V . Copyright © 2017 Elsevier Ltd. All rights reserved.

Biomedical Effects of Chemical-Threat-Agent Antidote and Pretreatment Drugs. An Abstracted Bibliography. Volume 1.

DTIC Science & Technology

1986-04-01

Adams, R., Venna, P., Jackson, A., and Miller, R. TITLE: Plasma pharmacokinetics of intravenously administered atropine in normal human subjects Journal...atropine by i.v. route and inhalation. Measurements of respiratory airway resistance, N2 closing volume, maximal expiratory flow volume, pressure volume...maximum flow -static recoil and esophageal elasticity were compared to non-atropinized values. FINDINGS: "I.V. administration produced a marked

Exploring the Origin of Differential Binding Affinities of Human Tubulin Isotypes αβII, αβIII and αβIV for DAMA-Colchicine Using Homology Modelling, Molecular Docking and Molecular Dynamics Simulations

PubMed Central

Panda, Dulal; Kunwar, Ambarish

2016-01-01

Tubulin isotypes are found to play an important role in regulating microtubule dynamics. The isotype composition is also thought to contribute in the development of drug resistance as tubulin isotypes show differential binding affinities for various anti-cancer agents. Tubulin isotypes αβII, αβIII and αβIV show differential binding affinity for colchicine. However, the origin of differential binding affinity is not well understood at the molecular level. Here, we investigate the origin of differential binding affinity of a colchicine analogue N-deacetyl-N-(2-mercaptoacetyl)-colchicine (DAMA-colchicine) for human αβII, αβIII and αβIV isotypes, employing sequence analysis, homology modeling, molecular docking, molecular dynamics simulation and MM-GBSA binding free energy calculations. The sequence analysis study shows that the residue compositions are different in the colchicine binding pocket of αβII and αβIII, whereas no such difference is present in αβIV tubulin isotypes. Further, the molecular docking and molecular dynamics simulations results show that residue differences present at the colchicine binding pocket weaken the bonding interactions and the correct binding of DAMA-colchicine at the interface of αβII and αβIII tubulin isotypes. Post molecular dynamics simulation analysis suggests that these residue variations affect the structure and dynamics of αβII and αβIII tubulin isotypes, which in turn affect the binding of DAMA-colchicine. Further, the binding free-energy calculation shows that αβIV tubulin isotype has the highest binding free-energy and αβIII has the lowest binding free-energy for DAMA-colchicine. The order of binding free-energy for DAMA-colchicine is αβIV ≃ αβII >> αβIII. Thus, our computational approaches provide an insight into the effect of residue variations on differential binding of αβII, αβIII and αβIV tubulin isotypes with DAMA-colchicine and may help to design new analogues with higher binding affinities for tubulin isotypes. PMID:27227832

A calculation procedure for viscous flow in turbomachines, volume 3. [computer programs

NASA Technical Reports Server (NTRS)

Khalil, I.; Sheoran, Y.; Tabakoff, W.

1980-01-01

A method for analyzing the nonadiabatic viscous flow through turbomachine blade passages was developed. The field analysis is based upon the numerical integration of the full incompressible Navier-Stokes equations, together with the energy equation on the blade-to-blade surface. A FORTRAN IV computer program was written based on this method. The numerical code used to solve the governing equations employs a nonorthogonal boundary fitted coordinate system. The flow may be axial, radial or mixed and there may be a change in stream channel thickness in the through-flow direction. The inputs required for two FORTRAN IV programs are presented. The first program considers laminar flows and the second can handle turbulent flows. Numerical examples are included to illustrate the use of the program, and to show the results that are obtained.

Nonlinear excited waves on the interventricular septum

NASA Astrophysics Data System (ADS)

Bekki, Naoaki; Harada, Yoshifumi; Kanai, Hiroshi

2012-11-01

Using a novel ultrasonic noninvasive imaging method, we observe some phase singularities in propagating excited waves on a human cardiac interventricular septum (IVS) for a healthy young male. We present a possible physical model explaining one-dimensional dynamics of phase singularities in nonlinearly excited waves on the IVS. We show that at least one of the observed phase singularities in the excited waves on the IVS can be explained by the Bekki-Nozaki hole solution of the complex Ginzburg-Landau equation without any adjustable parameters. We conclude that the complex Ginzburg-Landau equation is such a suitable model for one-dimensional dynamics of cardiac phase singularities in nonlinearly excited waves on the IVS.

FAST TRACK COMMUNICATION Generation of stable multi-jets by flow-limited field-injection electrostatic spraying and their control via I-V characteristics

NASA Astrophysics Data System (ADS)

Gu, W.; Heil, P. E.; Choi, H.; Kim, K.

2010-12-01

The I-V characteristics of flow-limited field-injection electrostatic spraying (FFESS) were investigated, exposing a new way to predict and control the specific spraying modes from single-jet to multi-jet. Monitoring the I-V characteristics revealed characteristic drops in the current upon formation of an additional jet in the multi-jet spraying mode. For fixed jet numbers, space-charge-limited current behaviour was measured which was attributed to space charge in the dielectric liquids between the needle electrode and the nozzle opening. The present work establishes that FFESS can, in particular, generate stable multiple jets and that their control is possible through monitoring the I-V characteristics. This can allow for automatic control of the FFESS process and expedite its future scientific and industrial applications.

The temporal evolution of explosive events and its implication on reconnection dynamics

NASA Astrophysics Data System (ADS)

Guo, L.; Liu, W.; De Pontieu, B.; Huang, Y. M.; Peter, H.; Bhattacharjee, A.

2017-12-01

Transition-region explosive events and other bursts seen in extreme UV light are characterized by broad spectral line profiles, and the more violent ones show a strong enhancement of emission. They are thought to be driven by magnetic reconnection, because of their characteristic spectral profiles often indicating strong Alfvénic flows, and because of the fact that they typically occur where magnetic flux concentrations of opposite polarity intersect. In this presentation, we will focus on the temporal evolution of transition-region explosive events. In particular, we will investigate fast onsets of these events and the rapid oscillations of intensity during these event. The fast onset refers to the beginning of an explosive event, where the intensities and the widths of its line profiles increase dramatically (often within less than 10 seconds) and the rapid oscillations of intensity refer to blinks of emission that usually last less than 10 seconds during the event. In order to interpret and understand underlying mechanisms of these observations, we conduct numerical simulation of an explosive event and calculate its spectra. We observe a similar temporal evolution in the synthetic Si IV spectra when the explosive event is driven by time-dependent reconnection—plasmoid instability. The qualitative agreement between observations and simulations suggests that the temporal evolution of Si IV spectra of explosive events are closely related to reconnection dynamics.

Effects of inhibition of nitric oxide synthase on basal anterior segment ocular blood flows and on potential autoregulatory mechanisms.

PubMed

Koss, M C

2001-08-01

Experiments were undertaken to determine the role played by nitric oxide (NO) in basal ocular blood flow in the anterior aspect of the eye. Subsequent studies focused on existence of autoregulatory mechanisms and on the potential involvement of NO. Cats were anesthetized with pentobarbital (36 mg/kg, i.p.). A femoral artery and vein were cannulated for measuring blood pressure and for drug administration, respectively. Anterior segment blood flow was measured in a continuous fashion from the long posterior ciliary artery (LPCA) using ultrasonic flowmetry and from the anterior choroid using laser-Doppler flowmetry. A needle was placed into the anterior chamber, and autoregulatory mechanisms were studied by decreasing ocular perfusion pressure via stepwise elevations of IOP. Non-selective inhibition of NO synthase with L-NAME (20 mg/kg, i.v.) significantly decreased basal blood flow from both sites. L-NAME (5 mg/kg, i.v.) was without effect as was D-NAME (25 mg/kg, i.v.). Increasing IOP produced a linear decrease on LPCA blood flow indicating absence of autoregulation. In contrast, stepwise elevation of IOP produced a delayed, non-linear response in the anterior choroid suggestive of a strong autoregulatory response. Neither response to elevated ocular perfusion pressure was further altered by inhibition of NO synthase with L-NAME (20 mg/kg, i.v.). The results confirm previous reports that nitric oxide plays a pivotal role in maintenance of basal ocular blood flow. Autoregulation was not seen in the LPCA. In contrast, there was a clear autoregulatory response in the anterior choroid, although neither response was altered by inhibition of NO synthase.

Calculating the Flow Field in a Radial Turbine Scroll

NASA Technical Reports Server (NTRS)

Baskharone, E.; Abdallah, S.; Hamed, A.; Tabaoff, W.

1983-01-01

Set of two computer programs calculates flow field in radial turbine scroll. Programs represent improvement in analyzing flow in radial turbine scrolls and provide designer with tools for designing better scrolls. Programs written in FORTRAN IV.

Airflow structures and nano-particle deposition in a human upper airway model

NASA Astrophysics Data System (ADS)

Zhang, Z.; Kleinstreuer, C.

2004-07-01

Considering a human upper airway model, or equivalently complex internal flow conduits, the transport and deposition of nano-particles in the 1-150 nm diameter range are simulated and analyzed for cyclic and steady flow conditions. Specifically, using a commercial finite-volume software with user-supplied programs as a solver, the Euler-Euler approach for the fluid-particle dynamics is employed with a low-Reynolds-number k- ω model for laminar-to-turbulent airflow and the mass transfer equation for dispersion of nano-particles or vapors. Presently, the upper respiratory system consists of two connected segments of a simplified human cast replica, i.e., the oral airways from the mouth to the trachea (Generation G0) and an upper tracheobronchial tree model of G0-G3. Experimentally validated computational fluid-particle dynamics results show the following: (i) transient effects in the oral airways appear most prominently during the decelerating phase of the inspiratory cycle; (ii) selecting matching flow rates, total deposition fractions of nano-size particles for cyclic inspiratory flow are not significantly different from those for steady flow; (iii) turbulent fluctuations which occur after the throat can persist downstream to at least Generation G3 at medium and high inspiratory flow rates (i.e., Qin⩾30 l/min) due to the enhancement of flow instabilities just upstream of the flow dividers; however, the effects of turbulent fluctuations on nano-particle deposition are quite minor in the human upper airways; (iv) deposition of nano-particles occurs to a relatively greater extent around the carinal ridges when compared to the straight tubular segments in the bronchial airways; (v) deposition distributions of nano-particles vary with airway segment, particle size, and inhalation flow rate, where the local deposition is more uniformly distributed for large-size particles (say, dp=100 nm) than for small-size particles (say, dp=1 nm); (vi) dilute 1 nm particle suspensions behave like certain (fuel) vapors which have the same diffusivities; and (vii) new correlations for particle deposition as a function of a diffusion parameter are most useful for global lung modeling.

Nonlinear Dynamics, Chaotic and Complex Systems

NASA Astrophysics Data System (ADS)

Infeld, E.; Zelazny, R.; Galkowski, A.

2011-04-01

Part I. Dynamic Systems Bifurcation Theory and Chaos: 1. Chaos in random dynamical systems V. M. Gunldach; 2. Controlling chaos using embedded unstable periodic orbits: the problem of optimal periodic orbits B. R. Hunt and E. Ott; 3. Chaotic tracer dynamics in open hydrodynamical flows G. Karolyi, A. Pentek, T. Tel and Z. Toroczkai; 4. Homoclinic chaos L. P. Shilnikov; Part II. Spatially Extended Systems: 5. Hydrodynamics of relativistic probability flows I. Bialynicki-Birula; 6. Waves in ionic reaction-diffusion-migration systems P. Hasal, V. Nevoral, I. Schreiber, H. Sevcikova, D. Snita, and M. Marek; 7. Anomalous scaling in turbulence: a field theoretical approach V. Lvov and I. Procaccia; 8. Abelian sandpile cellular automata M. Markosova; 9. Transport in an incompletely chaotic magnetic field F. Spineanu; Part III. Dynamical Chaos Quantum Physics and Foundations Of Statistical Mechanics: 10. Non-equilibrium statistical mechanics and ergodic theory L. A. Bunimovich; 11. Pseudochaos in statistical physics B. Chirikov; 12. Foundations of non-equilibrium statistical mechanics J. P. Dougherty; 13. Thermomechanical particle simulations W. G. Hoover, H. A. Posch, C. H. Dellago, O. Kum, C. G. Hoover, A. J. De Groot and B. L. Holian; 14. Quantum dynamics on a Markov background and irreversibility B. Pavlov; 15. Time chaos and the laws of nature I. Prigogine and D. J. Driebe; 16. Evolutionary Q and cognitive systems: dynamic entropies and predictability of evolutionary processes W. Ebeling; 17. Spatiotemporal chaos information processing in neural networks H. Szu; 18. Phase transitions and learning in neural networks C. Van den Broeck; 19. Synthesis of chaos A. Vanecek and S. Celikovsky; 20. Computational complexity of continuous problems H. Wozniakowski; Part IV. Complex Systems As An Interface Between Natural Sciences and Environmental Social and Economic Sciences: 21. Stochastic differential geometry in finance studies V. G. Makhankov; Part V. Conference Banquet Speech: Where will the future go? M. J. Feigenbaum.

Speciation of selenium and arsenic compounds by capillary electrophoresis with hydrodynamically modified electroosmotic flow and on-line reduction of selenium(VI) to selenium(IV) with hydride generation inductively coupled plasma mass spectrometric detection.

PubMed

Magnuson, M L; Creed, J T; Brockhoff, C A

1997-10-01

Capillary electrophoresis (CE) with hydride generation inductively coupled plasma mass spectrometry was used to determine four arsenicals and two selenium species. Selenate (SeVI) was reduced on-line to selenite (SeIV) by mixing the CE effluent with concentrated HCl. A microporous PTFE tube was used as a gas-liquid separator to eliminate the 40Ar37Cl and 40Ar35Cl interference from 77Se and 75As, respectively. The direction of the electroosmotic flow during CE was reversed with hydrodynamic pressure, which allowed increased freedom of buffer choice. For conventional pressure injection, method detection limits for SeIV and SeVI based on seven replicate injections were 10 and 24 pg, respectively. Recoveries of SeIV and SeVI in drinking water were measured.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hong, Taehoon, E-mail: hong7@yonsei.ac.kr; Kim, Jimin, E-mail: cookie6249@yonsei.ac.kr; Jeong, Kwangbok, E-mail: kbjeong7@yonsei.ac.kr

To systematically manage the energy consumption of existing buildings, the government has to enforce greenhouse gas reduction policies. However, most of the policies are not properly executed because they do not consider various factors from the urban level perspective. Therefore, this study aimed to conduct a dynamic analysis of an urban-based low-carbon policy using system dynamics, with a specific focus on housing and green space. This study was conducted in the following steps: (i) establishing the variables of urban-based greenhouse gases (GHGs) emissions; (ii) creating a stock/flow diagram of urban-based GHGs emissions; (iii) conducting an information analysis using the systemmore » dynamics; and (iv) proposing the urban-based low-carbon policy. If a combined energy policy that uses the housing sector (30%) and the green space sector (30%) at the same time is implemented, 2020 CO{sub 2} emissions will be 7.23 million tons (i.e., 30.48% below 2020 business-as-usual), achieving the national carbon emissions reduction target (26.9%). The results of this study could contribute to managing and improving the fundamentals of the urban-based low-carbon policies to reduce greenhouse gas emissions.« less

Does the Dynamic Indicators of Basic Early Literacy Skills Next Assessment Take a "Simple View" of Reading?

ERIC Educational Resources Information Center

Munger, Kristen A.; LoFaro, Stephen A.; Kawryga, Erin A.; Sovocool, Elizabeth A.; Medina, Siani Y.

2014-01-01

This study involved examination of the validity evidence of the Dynamic Indicators of Basic Early Literacy Skills-Next Edition (DIBELS Next) for a sample of 85 third-and fifth-grade students, in reference to the "simple view" of reading. Tests administered included DIBELS Next, Peabody Picture Vocabulary Test-IV (PPVT-IV), Group Reading…

Multi-scale approach to the modeling of fission gas discharge during hypothetical loss-of-flow accident in gen-IV sodium fast reactor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Behafarid, F.; Shaver, D. R.; Bolotnov, I. A.

The required technological and safety standards for future Gen IV Reactors can only be achieved if advanced simulation capabilities become available, which combine high performance computing with the necessary level of modeling detail and high accuracy of predictions. The purpose of this paper is to present new results of multi-scale three-dimensional (3D) simulations of the inter-related phenomena, which occur as a result of fuel element heat-up and cladding failure, including the injection of a jet of gaseous fission products into a partially blocked Sodium Fast Reactor (SFR) coolant channel, and gas/molten sodium transport along the coolant channels. The computational approachmore » to the analysis of the overall accident scenario is based on using two different inter-communicating computational multiphase fluid dynamics (CMFD) codes: a CFD code, PHASTA, and a RANS code, NPHASE-CMFD. Using the geometry and time history of cladding failure and the gas injection rate, direct numerical simulations (DNS), combined with the Level Set method, of two-phase turbulent flow have been performed by the PHASTA code. The model allows one to track the evolution of gas/liquid interfaces at a centimeter scale. The simulated phenomena include the formation and breakup of the jet of fission products injected into the liquid sodium coolant. The PHASTA outflow has been averaged over time to obtain mean phasic velocities and volumetric concentrations, as well as the liquid turbulent kinetic energy and turbulence dissipation rate, all of which have served as the input to the core-scale simulations using the NPHASE-CMFD code. A sliding window time averaging has been used to capture mean flow parameters for transient cases. The results presented in the paper include testing and validation of the proposed models, as well the predictions of fission-gas/liquid-sodium transport along a multi-rod fuel assembly of SFR during a partial loss-of-flow accident. (authors)« less

Modeling the impact of soil aggregate size on selenium immobilization

NASA Astrophysics Data System (ADS)

Kausch, M. F.; Pallud, C. E.

2013-03-01

Soil aggregates are mm- to cm-sized microporous structures separated by macropores. Whereas fast advective transport prevails in macropores, advection is inhibited by the low permeability of intra-aggregate micropores. This can lead to mass transfer limitations and the formation of aggregate scale concentration gradients affecting the distribution and transport of redox sensitive elements. Selenium (Se) mobilized through irrigation of seleniferous soils has emerged as a major aquatic contaminant. In the absence of oxygen, the bioavailable oxyanions selenate, Se(VI), and selenite, Se(IV), can be microbially reduced to solid, elemental Se, Se(0), and anoxic microzones within soil aggregates are thought to promote this process in otherwise well-aerated soils. To evaluate the impact of soil aggregate size on selenium retention, we developed a dynamic 2-D reactive transport model of selenium cycling in a single idealized aggregate surrounded by a macropore. The model was developed based on flow-through-reactor experiments involving artificial soil aggregates (diameter: 2.5 cm) made of sand and containing Enterobacter cloacae SLD1a-1 that reduces Se(VI) via Se(IV) to Se(0). Aggregates were surrounded by a constant flow providing Se(VI) and pyruvate under oxic or anoxic conditions. In the model, reactions were implemented with double-Monod rate equations coupled to the transport of pyruvate, O2, and Se species. The spatial and temporal dynamics of the model were validated with data from experiments, and predictive simulations were performed covering aggregate sizes 1-2.5 cm in diameter. Simulations predict that selenium retention scales with aggregate size. Depending on O2, Se(VI), and pyruvate concentrations, selenium retention was 4-23 times higher in 2.5 cm aggregates compared to 1 cm aggregates. Under oxic conditions, aggregate size and pyruvate concentrations were found to have a positive synergistic effect on selenium retention. Promoting soil aggregation on seleniferous agricultural soils, through organic matter amendments and conservation tillage, may thus help decrease the impacts of selenium contaminated drainage water on downstream aquatic ecosystems.

Modeling the impact of soil aggregate size on selenium immobilization

NASA Astrophysics Data System (ADS)

Kausch, M. F.; Pallud, C. E.

2012-09-01

Soil aggregates are mm- to cm-sized microporous structures separated by macropores. Whereas fast advective transport prevails in macropores, advection is inhibited by the low permeability of intra-aggregate micropores. This can lead to mass transfer limitations and the formation of aggregate-scale concentration gradients affecting the distribution and transport of redox sensitive elements. Selenium (Se) mobilized through irrigation of seleniferous soils has emerged as a major aquatic contaminant. In the absence of oxygen, the bioavailable oxyanions selenate, Se(VI), and selenite, Se(IV), can be microbially reduced to solid, elemental Se, Se(0), and anoxic microzones within soil aggregates are thought to promote this process in otherwise well aerated soils. To evaluate the impact of soil aggregate size on selenium retention, we developed a dynamic 2-D reactive transport model of selenium cycling in a single idealized aggregate surrounded by a macropore. The model was developed based on flow-through-reactor experiments involving artificial soil aggregates (diameter: 2.5 cm) made of sand and containing Enterobacter cloacae SLD1a-1 that reduces Se(VI) via Se(IV) to Se(0). Aggregates were surrounded by a constant flow providing Se(VI) and pyruvate under oxic or anoxic conditions. In the model, reactions were implemented with double-Monod rate equations coupled to the transport of pyruvate, O2, and Se-species. The spatial and temporal dynamics of the model were validated with data from experiments and predictive simulations were performed covering aggregate sizes between 1 and 2.5 cm diameter. Simulations predict that selenium retention scales with aggregate size. Depending on O2, Se(VI), and pyruvate concentrations, selenium retention was 4-23 times higher in 2.5-cm-aggregates compared to 1-cm-aggregates. Under oxic conditions, aggregate size and pyruvate-concentrations were found to have a positive synergistic effect on selenium retention. Promoting soil aggregation on seleniferous agricultural soils, through organic matter amendments and conservation tillage, may thus help decrease the impacts of selenium contaminated drainage water on downstream aquatic ecosystems.

Airport Network Flow Simulator

DOT National Transportation Integrated Search

1978-10-01

The Airport Network Flow Simulator is a FORTRAN IV simulation of the flow of air traffic in the nation's 600 commercial airports. It calculates for any group of selected airports: (a) the landing and take-off (Type A) delays; and (b) the gate departu...

The role of charge transfer in the oxidation state change of Ce atoms in the TM13-CeO2(111) systems (TM = Pd, Ag, Pt, Au): a DFT + U investigation.

PubMed

Tereshchuk, Polina; Freire, Rafael L H; Ungureanu, Crina G; Seminovski, Yohanna; Kiejna, Adam; Da Silva, Juarez L F

2015-05-28

Despite extensive studies of transition metal (TM) clusters supported on ceria (CeO2), fundamental issues such as the role of the TM atoms in the change in the oxidation state of Ce atoms are still not well understood. In this work, we report a theoretical investigation based on static and ab initio molecular dynamics density functional theory calculations of the interaction of 13-atom TM clusters (TM = Pd, Ag, Pt, Au) with the unreduced CeO2(111) surface represented by a large surface unit cell and employing Hubbard corrections for the strong on-site Coulomb correlation in the Ce f-electrons. We found that the TM13 clusters form pyramidal-like structures on CeO2(111) in the lowest energy configurations with the following stacking sequence, TM/TM4/TM8/CeO2(111), while TM13 adopts two-dimensional structures at high energy structures. TM13 induces a change in the oxidation state of few Ce atoms (3 of 16) located in the topmost Ce layer from Ce(IV) (itinerant Ce f-states) to Ce(III) (localized Ce f-states). There is a charge flow from the TM atoms to the CeO2(111) surface, which can be explained by the electronegativity difference between the TM (Pd, Ag, Pt, Au) and O atoms, however, the charge is not uniformly distributed on the topmost O layer due to the pressure induced by the TM13 clusters on the underlying O ions, which yields a decrease in the ionic charge of the O ions located below the cluster and an increase in the remaining O ions. Due to the charge flow mainly from the TM8-layer to the topmost O-layer, the charge cannot flow from the Ce(IV) atoms to the O atoms with the same magnitude as in the clean CeO2(111) surface. Consequently, the effective cationic charge decreases mainly for the Ce atoms that have a bond with the O atoms not located below the cluster, and hence, those Ce atoms change their oxidation state from IV to III. This increases the size of the Ce(III) compared with the Ce(IV) cations, which builds-in a strain within the topmost Ce layer, and hence, also affecting the location of the Ce(III) cations and the structure of the TM13 clusters.

Tumor Blood Vessel Dynamics

NASA Astrophysics Data System (ADS)

Munn, Lance

2009-11-01

``Normalization'' of tumor blood vessels has shown promise to improve the efficacy of chemotherapeutics. In theory, anti-angiogenic drugs targeting endothelial VEGF signaling can improve vessel network structure and function, enhancing the transport of subsequent cytotoxic drugs to cancer cells. In practice, the effects are unpredictable, with varying levels of success. The predominant effects of anti-VEGF therapies are decreased vessel leakiness (hydraulic conductivity), decreased vessel diameters and pruning of the immature vessel network. It is thought that each of these can influence perfusion of the vessel network, inducing flow in regions that were previously sluggish or stagnant. Unfortunately, when anti-VEGF therapies affect vessel structure and function, the changes are dynamic and overlapping in time, and it has been difficult to identify a consistent and predictable normalization ``window'' during which perfusion and subsequent drug delivery is optimal. This is largely due to the non-linearity in the system, and the inability to distinguish the effects of decreased vessel leakiness from those due to network structural changes in clinical trials or animal studies. We have developed a mathematical model to calculate blood flow in complex tumor networks imaged by two-photon microscopy. The model incorporates the necessary and sufficient components for addressing the problem of normalization of tumor vasculature: i) lattice-Boltzmann calculations of the full flow field within the vasculature and within the tissue, ii) diffusion and convection of soluble species such as oxygen or drugs within vessels and the tissue domain, iii) distinct and spatially-resolved vessel hydraulic conductivities and permeabilities for each species, iv) erythrocyte particles advecting in the flow and delivering oxygen with real oxygen release kinetics, v) shear stress-mediated vascular remodeling. This model, guided by multi-parameter intravital imaging of tumor vessel structure and function, provides a tool for identifying the structural and functional determinants of tumor vessel normalization.

Diffuse interface modeling of three-phase contact line dynamics on curved boundaries: A lattice Boltzmann model for large density and viscosity ratios

NASA Astrophysics Data System (ADS)

Fakhari, Abbas; Bolster, Diogo

2017-04-01

We introduce a simple and efficient lattice Boltzmann method for immiscible multiphase flows, capable of handling large density and viscosity contrasts. The model is based on a diffuse-interface phase-field approach. Within this context we propose a new algorithm for specifying the three-phase contact angle on curved boundaries within the framework of structured Cartesian grids. The proposed method has superior computational accuracy compared with the common approach of approximating curved boundaries with stair cases. We test the model by applying it to four benchmark problems: (i) wetting and dewetting of a droplet on a flat surface and (ii) on a cylindrical surface, (iii) multiphase flow past a circular cylinder at an intermediate Reynolds number, and (iv) a droplet falling on hydrophilic and superhydrophobic circular cylinders under differing conditions. Where available, our results show good agreement with analytical solutions and/or existing experimental data, highlighting strengths of this new approach.

Analytical study on different blade-shape design of HAWT for wasted kinetic energy recovery system (WKERS)

NASA Astrophysics Data System (ADS)

Goh, J. B.; Jamaludin, Z.; Jafar, F. A.; Mat Ali, M.; Mokhtar, M. N. Ali; Tan, C. H.

2017-06-01

Wasted kinetic energy recovery system (WKERS) is a wind renewable gadget installed above a cooling tower outlet to harvest the discharged wind for electrical regeneration purpose. The previous WKERS is operated by a horizontal axis wind turbine (HAWT) with delta blade design but the performance is still not at the optimum level. Perhaps, a better blade-shape design should be determined to obtain the optimal performance, as it is believed that the blade-shape design plays a critical role in HAWT. Hence, to determine a better blade-shape design for a new generation of WKERS, elliptical blade, swept blade and NREL Phase IV blade are selected for this benchmarking process. NREL Phase IV blade is a modern HAWT’s blade design by National Renewable Energy Laboratory (NREL) research lab. During the process of benchmarking, Computational Fluid Dynamics (CFD) analysis was ran by using SolidWorks design software, where all the designs are simulated with linear flow simulation. The wind speed in the simulation is set at 10.0 m/s, which is compatible with the average wind speed produced by a standard size cooling tower. The result is obtained by flow trajectories of air motion, surface plot and cut plot of the applied blade-shape. Besides, the aspect ratio of each blade is calculated and included as one of the reference in the comparison. Hence, the final selection of the best blade-shape design will bring to the new generation of WKERS.

Experimental Investigation of Secondary Flow Structures Downstream of a Model Type IV Stent Failure in a 180° Curved Artery Test Section.

PubMed

Bulusu, Kartik V; Plesniak, Michael W

2016-07-19

The arterial network in the human vasculature comprises of ubiquitously present blood vessels with complex geometries (branches, curvatures and tortuosity). Secondary flow structures are vortical flow patterns that occur in curved arteries due to the combined action of centrifugal forces, adverse pressure gradients and inflow characteristics. Such flow morphologies are greatly affected by pulsatility and multiple harmonics of physiological inflow conditions and vary greatly in size-strength-shape characteristics compared to non-physiological (steady and oscillatory) flows (1 - 7). Secondary flow structures may ultimately influence the wall shear stress and exposure time of blood-borne particles toward progression of atherosclerosis, restenosis, sensitization of platelets and thrombosis (4 - 6, 8 - 13). Therefore, the ability to detect and characterize these structures under laboratory-controlled conditions is precursor to further clinical investigations. A common surgical treatment to atherosclerosis is stent implantation, to open up stenosed arteries for unobstructed blood flow. But the concomitant flow perturbations due to stent installations result in multi-scale secondary flow morphologies (4 - 6). Progressively higher order complexities such as asymmetry and loss in coherence can be induced by ensuing stent failures vis-à-vis those under unperturbed flows (5). These stent failures have been classified as "Types I-to-IV" based on failure considerations and clinical severity (14). This study presents a protocol for the experimental investigation of the complex secondary flow structures due to complete transverse stent fracture and linear displacement of fractured parts ("Type IV") in a curved artery model. The experimental method involves the implementation of particle image velocimetry (2C-2D PIV) techniques with an archetypal carotid artery inflow waveform, a refractive index matched blood-analog working fluid for phase-averaged measurements (15 - 18). Quantitative identification of secondary flow structures was achieved using concepts of flow physics, critical point theory and a novel wavelet transform algorithm applied to experimental PIV data (5, 6, 19 - 26).

A case study for hydromagnetic outflow in active galactic nuclei: NGC 5548

NASA Astrophysics Data System (ADS)

Bottorff, Mark Clinton

1999-01-01

A hydromagnetic (MHD) wind from a clumpy molecular accretion disk surrounding a supermassive black hole is invoked to explain observed emission and absorption features of gas at UV and X-ray energies in Seyfert 1 galaxies. It is the first attempt to explain a wide range of phenomena observed on the periphery of Active Galactic Nuclei (AGN) with a single dynamical model and within the framework of the AGN unification scheme. In the first part of this thesis, the results of long- term observations of the broadline region (BLR) in the Seyfert 1 galaxy NGC 5548 are analyzed and a critical comparison with the predictions of a hydromagnetically- driven outflow model is provided. The model reproduces the basic features of C IV line variability in this AGN, i.e., time evolution of the profile shape and strength of the C IV emission line without varying the model parameters . The best fit model provides the effective size, the dominant geometry, the emissivity distribution and the 3D velocity field of the C IV BLR and constrains the mass of the central black hole to ~3×107 Msolar . The inner part of the wind in NGC 5548 appears to be responsible for the anisotropically emitted C IV line, while its outer part remains dusty and molecular, thus having similar spectral characteristics to a molecular torus. In addition, the model predicts a differential response across the C IV line profile, producing a red-side-first response in the relative velocity interval of 3,000 km s-1 to 6,000 km s -1 followed by the blue mid-wing and finally by the line core. In the second part of this dissertation, we have analyzed the UV and X-ray absorption in NGC 5548 within the framework of warm absorbing gas. We focus on two important issues: (1)compatibility of kinematics and dynamics of the MHD wind with the observed properties of warm absorbers; and (2)the relationship between the UV and X-ray absorbing gases. An in-depth comparison between the MHD wind model and the well-studied Seyfert 1 galaxy NGC 5548 is made, which at high spectral resolution exhibits a number of discrete UV absorption components. Our results show that for NGC 5548: (1)the total column densities of O VII, O VIII and H, inferred from X-ray observations are reproduced by constraining the UV ion column densities of C IV and N V in each component to lie within a factor of 2 of their observed values; (2)the warm absorbing gas exists in the outer part of the wind and is not a continuation of the flow in the broad emission-line region; and (3)the warm absorber extends both in radial and polar directions and is ionization stratified. Analysis shows that the discrete absorption components along the line-of-sight are intrinsically clumpy. The applicability of the MHD wind to warm absorbers is further tested by constructing a quasi-continuous flow model and extending it to arbitrary aspect angles. We find that the ratio of O VII to O VIII optical depths can serve as a new diagnostic of AGN aspect angle. (Abstract shortened by UMI.)

Angiotensin II Type 1 Receptor Antagonism Attenuates Abnormalities in Dynamic Renal Blood Flow Autoregulation in Rats with Endotoxin-Induced Acute Kidney Injury.

PubMed

Nitescu, Nicoletta; DiBona, Gerald F; Grimberg, Elisabeth; Guron, Gregor

2010-01-01

The aim was to examine the role of angiotensin II type 1 receptors in dynamic autoregulation of renal blood flow (RBF) in endotoxemia. Experiments were performed on anesthetized rats 16 h after intraperitoneal lipopolysaccharide (LPS) or vehicle administration. After baseline measurements, groups Sham-Saline, LPS-Saline and LPS-Candesartan received isotonic saline or candesartan (10 μg kg(-1) i.v.). Data were collected during eight consecutive 20-min clearance periods (C1-8). Transfer function (TF) analysis in the frequency domain was used to examine dynamic autoregulation of RBF. Endotoxemic rats showed an approximate 50% reduction in glomerular filtration rate (GFR) and RBF (p < 0.05 vs. Sham-Saline). Candesartan significantly increased RBF (+40 ± 6% vs. baseline; p < 0.05) but did not significantly influence GFR. Endotoxemic animals showed a normal myogenic response but had elevated TF gain values in the frequency range of the tubuloglomerular feedback mechanism (TGF; 0.01-0.03 Hz) reflecting impaired autoregulation (periods C3-4, 2.2 ± 1.6 vs. -2.6 ± 0.6 dB, p < 0.05, and C7-8, -0.4 ± 1.3 vs. -4.0 ± 0.8 dB, p < 0.05; in groups LPS-Saline and Sham-Saline, respectively). Candesartan normalized TF gain in this frequency range (periods C7-8, -6.1 ± 2.3 dB in group LPS-Candesartan, p < 0.05 vs. LPS-Saline). Candesartan ameliorates the adverse effect of endotoxin on the TGF component of dynamic autoregulation of RBF. Copyright © 2010 S. Karger AG, Basel.

An Analog Macroscopic Technique for Studying Molecular Hydrodynamic Processes in Dense Gases and Liquids.

PubMed

Dahlberg, Jerry; Tkacik, Peter T; Mullany, Brigid; Fleischhauer, Eric; Shahinian, Hossein; Azimi, Farzad; Navare, Jayesh; Owen, Spencer; Bisel, Tucker; Martin, Tony; Sholar, Jodie; Keanini, Russell G

2017-12-04

An analog, macroscopic method for studying molecular-scale hydrodynamic processes in dense gases and liquids is described. The technique applies a standard fluid dynamic diagnostic, particle image velocimetry (PIV), to measure: i) velocities of individual particles (grains), extant on short, grain-collision time-scales, ii) velocities of systems of particles, on both short collision-time- and long, continuum-flow-time-scales, iii) collective hydrodynamic modes known to exist in dense molecular fluids, and iv) short- and long-time-scale velocity autocorrelation functions, central to understanding particle-scale dynamics in strongly interacting, dense fluid systems. The basic system is composed of an imaging system, light source, vibrational sensors, vibrational system with a known media, and PIV and analysis software. Required experimental measurements and an outline of the theoretical tools needed when using the analog technique to study molecular-scale hydrodynamic processes are highlighted. The proposed technique provides a relatively straightforward alternative to photonic and neutron beam scattering methods traditionally used in molecular hydrodynamic studies.

Streamflow Prediction in Ungauged, Irrigated Basins

NASA Astrophysics Data System (ADS)

Zhang, M.; Thompson, S. E.

2016-12-01

The international "predictions in ungauged basins" or "PUB" effort has broadened and improved the tools available to support water resources management in sparsely observed regions. These tools have, however, been primarily focused on regions with limited diversion of surface or shallow groundwater resources. Incorporating anthropogenic activity into PUB methods is essential given the high level of development of many basins. We extended an existing stochastic framework used to predict the flow duration curve to explore the effects of irrigation on streamflow dynamics. Four canonical scenarios were considered in which irrigation water was (i) primarily sourced from water imports, (ii) primarily sourced from direct in-channel diversions, (iii) sourced from shallow groundwater with direct connectivity to stream channels, or (iv) sourced from deep groundwater that is indirectly connected to surface flow via a shallow aquifer. By comparing the predicted flow duration curves to those predicted by accounting for climate and geomorphic factors in isolation, specific "fingerprints" of human water withdrawals could be identified for the different irrigation scenarios, and shown to be sensitive to irrigation volumes and scheduling. The results provide a first insight into PUB methodologies that could be employed in heavily managed basins.

Mass motions in the solar chromosphere and transition zone

NASA Technical Reports Server (NTRS)

Mein, P.; Simon, G.; Vial, J. C.; Shine, R. A.

1982-01-01

A comparison is made between H-alpha and C IV observations of Active Region 2717 on October 9, 1980. On the basis of this comparison, it is found that upward velocities are present above sunspots in the chromosphere-corona transition zone (20 km/s). The downward velocities are found to be well correlated in both lines. Doppler-shift ratios between C IV and H-alpha levels (approximately 10) are seen to be much smaller than expected from density ratio estimates. The comparison is seen as suggesting that flow lines are probably far from vertical in the transition zone. It is pointed out, however, that this depends on model densities that may not be correct. A simple method for comparing matter flows is presented. The best fit between H-alpha and C IV levels is obtained when C IV Doppler shifts are multiplied by the line intensity to the power 0.5 (approximately) in order to make allowance for density fluctuations.

CDDIS Data Center Summary for the IVS 2012 Annual Report

NASA Technical Reports Server (NTRS)

Noll, Carey

2013-01-01

This report summarizes activities during 2012 and future plans of the Crustal Dynamics Data Information System (CDDIS) with respect to the International VLBI Service for Geodesy and Astrometry (IVS). Included in this report are background information about the CDDIS, the computer architecture, staff supporting the system, archive contents, and future plans for the CDDIS within the IVS.

40 CFR 63.5385 - How do I measure the quantity of finish applied to the leather?

Code of Federal Regulations, 2010 CFR

2010-07-01

...) of this section: (i) Locate the flow sensor and other necessary equipment such as straightening vanes in or as close to a position that provides a representative flow. (ii) Use a flow sensor with a... distributions due to upstream and downstream disturbances. (iv) Conduct a flow sensor calibration check at least...

40 CFR 63.5385 - How do I measure the quantity of finish applied to the leather?

Code of Federal Regulations, 2011 CFR

2011-07-01

...) of this section: (i) Locate the flow sensor and other necessary equipment such as straightening vanes in or as close to a position that provides a representative flow. (ii) Use a flow sensor with a... distributions due to upstream and downstream disturbances. (iv) Conduct a flow sensor calibration check at least...

40 CFR 63.5385 - How do I measure the quantity of finish applied to the leather?

Code of Federal Regulations, 2014 CFR

2014-07-01

...) through (v) of this section: (i) Locate the flow sensor and other necessary equipment such as straightening vanes in or as close to a position that provides a representative flow. (ii) Use a flow sensor... distributions due to upstream and downstream disturbances. (iv) Conduct a flow sensor calibration check at least...

40 CFR 63.5385 - How do I measure the quantity of finish applied to the leather?

Code of Federal Regulations, 2013 CFR

2013-07-01

...) through (v) of this section: (i) Locate the flow sensor and other necessary equipment such as straightening vanes in or as close to a position that provides a representative flow. (ii) Use a flow sensor... distributions due to upstream and downstream disturbances. (iv) Conduct a flow sensor calibration check at least...

40 CFR 63.5385 - How do I measure the quantity of finish applied to the leather?

Code of Federal Regulations, 2012 CFR

2012-07-01

...) through (v) of this section: (i) Locate the flow sensor and other necessary equipment such as straightening vanes in or as close to a position that provides a representative flow. (ii) Use a flow sensor... distributions due to upstream and downstream disturbances. (iv) Conduct a flow sensor calibration check at least...

Effect of External Pressure and Catheter Gauge on Flow Rate, Kinetic Energy, and Endothelial Injury During Intravenous Fluid Administration in a Rabbit Model.

PubMed

Hu, Mei-Hua; Chan, Wei-Hung; Chen, Yao-Chang; Cherng, Chen-Hwan; Lin, Chih-Kung; Tsai, Chien-Sung; Chou, Yu-Ching; Huang, Go-Shine

2016-01-01

The effects of intravenous (IV) catheter gauge and pressurization of IV fluid (IVF) bags on fluid flow rate have been studied. However, the pressure needed to achieve a flow rate equivalent to that of a 16 gauge (G) catheter through smaller G catheters and the potential for endothelial damage from the increased kinetic energy produced by higher pressurization are unclear. Constant pressure on an IVF bag was maintained by an automatic adjustable pneumatic pressure regulator of our own design. Fluids running through 16 G, 18 G, 20 G, and 22 G catheters were assessed while using IV bag pressurization to achieve the flow rate equivalent to that of a 16 G catheter. We assessed flow rates, kinetic energy, and flow injury to rabbit inferior vena cava endothelium. By applying sufficient external constant pressure to an IVF bag, all fluids could be run through smaller (G) catheters at the flow rate in a 16 G catheter. However, the kinetic energy increased significantly as the catheter G increased. Damage to the venous endothelium was negligible or minimal/patchy cell loss. We designed a new rapid infusion system, which provides a constant pressure that compresses the fluid volume until it is free from visible residual fluid. When large-bore venous access cannot be obtained, multiple smaller catheters, external pressure, or both should be considered. However, caution should be exercised when fluid pressurized to reach a flow rate equivalent to that in a 16 G catheter is run through a smaller G catheter because of the profound increase in kinetic energy that can lead to venous endothelium injury.

A 37-mm Ceramic Gun Nozzle Stress Analysis

DTIC Science & Technology

2006-05-01

Figures iv List of Tables iv 1 . Introduction 1 2. Ceramic Nozzle Structure and Materials 1 3. Sequentially-Coupled and Fully-Coupled Thermal Stress...FEM Analysis 1 4. Ceramic Nozzle Thermal Stress Response 4 5. Ceramic Nozzle Dynamic FEM 7 6. Ceramic Nozzle Dynamic Responses and Discussions 8 7...candidate ceramics and the test fixture model components are listed in table 1 . 3. Sequentially-Coupled and Fully-Coupled Thermal Stress FEM Analysis

Fast Particle Methods for Multiscale Phenomena Simulations

NASA Technical Reports Server (NTRS)

Koumoutsakos, P.; Wray, A.; Shariff, K.; Pohorille, Andrew

2000-01-01

We are developing particle methods oriented at improving computational modeling capabilities of multiscale physical phenomena in : (i) high Reynolds number unsteady vortical flows, (ii) particle laden and interfacial flows, (iii)molecular dynamics studies of nanoscale droplets and studies of the structure, functions, and evolution of the earliest living cell. The unifying computational approach involves particle methods implemented in parallel computer architectures. The inherent adaptivity, robustness and efficiency of particle methods makes them a multidisciplinary computational tool capable of bridging the gap of micro-scale and continuum flow simulations. Using efficient tree data structures, multipole expansion algorithms, and improved particle-grid interpolation, particle methods allow for simulations using millions of computational elements, making possible the resolution of a wide range of length and time scales of these important physical phenomena.The current challenges in these simulations are in : [i] the proper formulation of particle methods in the molecular and continuous level for the discretization of the governing equations [ii] the resolution of the wide range of time and length scales governing the phenomena under investigation. [iii] the minimization of numerical artifacts that may interfere with the physics of the systems under consideration. [iv] the parallelization of processes such as tree traversal and grid-particle interpolations We are conducting simulations using vortex methods, molecular dynamics and smooth particle hydrodynamics, exploiting their unifying concepts such as : the solution of the N-body problem in parallel computers, highly accurate particle-particle and grid-particle interpolations, parallel FFT's and the formulation of processes such as diffusion in the context of particle methods. This approach enables us to transcend among seemingly unrelated areas of research.

17 CFR 229.1121 - (Item 1121) Distribution and pool performance information.

Code of Federal Regulations, 2012 CFR

2012-04-01

... and actual distribution dates for the distribution period. (2) Cash flows received and the sources... shortfalls or carryovers. (iv) The amount of excess cash flow or excess spread and the disposition of excess cash flow. (4) Beginning and ending principal balances of the asset-backed securities. (5) Interest...

17 CFR 229.1121 - (Item 1121) Distribution and pool performance information.

Code of Federal Regulations, 2011 CFR

2011-04-01

... and actual distribution dates for the distribution period. (2) Cash flows received and the sources... shortfalls or carryovers. (iv) The amount of excess cash flow or excess spread and the disposition of excess cash flow. (4) Beginning and ending principal balances of the asset-backed securities. (5) Interest...

17 CFR 229.1121 - (Item 1121) Distribution and pool performance information.

Code of Federal Regulations, 2014 CFR

2014-04-01

... and actual distribution dates for the distribution period. (2) Cash flows received and the sources... shortfalls or carryovers. (iv) The amount of excess cash flow or excess spread and the disposition of excess cash flow. (4) Beginning and ending principal balances of the asset-backed securities. (5) Interest...

17 CFR 229.1121 - (Item 1121) Distribution and pool performance information.

Code of Federal Regulations, 2013 CFR

2013-04-01

... and actual distribution dates for the distribution period. (2) Cash flows received and the sources... shortfalls or carryovers. (iv) The amount of excess cash flow or excess spread and the disposition of excess cash flow. (4) Beginning and ending principal balances of the asset-backed securities. (5) Interest...

Stochastic optimization for the detection of changes in maternal heart rate kinetics during pregnancy

NASA Astrophysics Data System (ADS)

Zakynthinaki, M. S.; Barakat, R. O.; Cordente Martínez, C. A.; Sampedro Molinuevo, J.

2011-03-01

The stochastic optimization method ALOPEX IV has been successfully applied to the problem of detecting possible changes in the maternal heart rate kinetics during pregnancy. For this reason, maternal heart rate data were recorded before, during and after gestation, during sessions of exercises of constant mild intensity; ALOPEX IV stochastic optimization was used to calculate the parameter values that optimally fit a dynamical systems model to the experimental data. The results not only demonstrate the effectiveness of ALOPEX IV stochastic optimization, but also have important implications in the area of exercise physiology, as they reveal important changes in the maternal cardiovascular dynamics, as a result of pregnancy.

CDDIS Data Center Summary for the 2004 IVS Annual Report

NASA Technical Reports Server (NTRS)

Noll, Carey

2005-01-01

This report summarizes activities during the year 2004 and future plans of the Crustal Dynamics Data Information System (CDDIS) with respect to the International VLBI service for Geodesy and Astrometry (IVS). Included in this report are background information about the CDDIS, the computer architecture, staffing the support system, archive contents, and future plans for the CDDIS within the IVS.

CDDIS Data Center Summary for the 2003 IVS Annual Report

NASA Technical Reports Server (NTRS)

Noll, Carey

2004-01-01

This report summarizes activities during the year 2003 and future plans of the Crustal Dynamics Data Information System (CDDIS) with respect to the International VLBI Service for Geodesy and Astrometry (IVS). Included in this report are background information about the CDDIS, the computer architecture, staffing supporting the system, archive contents, and future plans for the CDDIS within the IVS.

Theoretical fluid dynamics

NASA Astrophysics Data System (ADS)

Shivamoggi, B. K.

This book is concerned with a discussion of the dynamical behavior of a fluid, and is addressed primarily to graduate students and researchers in theoretical physics and applied mathematics. A review of basic concepts and equations of fluid dynamics is presented, taking into account a fluid model of systems, the objective of fluid dynamics, the fluid state, description of the flow field, volume forces and surface forces, relative motion near a point, stress-strain relation, equations of fluid flows, surface tension, and a program for analysis of the governing equations. The dynamics of incompressible fluid flows is considered along with the dynamics of compressible fluid flows, the dynamics of viscous fluid flows, hydrodynamic stability, and dynamics of turbulence. Attention is given to the complex-variable method, three-dimensional irrotational flows, vortex flows, rotating flows, water waves, applications to aerodynamics, shock waves, potential flows, the hodograph method, flows at low and high Reynolds numbers, the Jeffrey-Hamel flow, and the capillary instability of a liquid jet.

Flow instabilities of magnetic flux tubes. IV. Flux storage in the solar overshoot region

NASA Astrophysics Data System (ADS)

Işık, E.; Holzwarth, V.

2009-12-01

Context: Flow-induced instabilities of magnetic flux tubes are relevant to the storage of magnetic flux in the interiors of stars with outer convection zones. The stability of magnetic fields in stellar interiors is of importance to the generation and transport of solar and stellar magnetic fields. Aims: We consider the effects of material flows on the dynamics of toroidal magnetic flux tubes located close to the base of the solar convection zone, initially within the overshoot region. The problem is to find the physical conditions in which magnetic flux can be stored for periods comparable to the dynamo amplification time, which is of the order of a few years. Methods: We carry out nonlinear numerical simulations to investigate the stability and dynamics of thin flux tubes subject to perpendicular and longitudinal flows. We compare the simulations with the results of simplified analytical approximations. Results: The longitudinal flow instability induced by the aerodynamic drag force is nonlinear in the sense that the growth rate depends on the perturbation amplitude. This result is consistent with the predictions of linear theory. Numerical simulations without friction show that nonlinear Parker instability can be triggered below the linear threshold of the field strength, when the difference in superadiabaticity along the tube is sufficiently large. A localised downflow acting on a toroidal tube in the overshoot region leads to instability depending on the parameters describing the flow, as well as the magnetic field strength. We determined ranges of the flow parameters for which a linearly Parker-stable magnetic flux tube is stored in the middle of the overshoot region for a period comparable to the dynamo amplification time. Conclusions: The longitudinal flow instability driven by frictional interaction of a flux tube with its surroundings is relevant to determining the storage time of magnetic flux in the solar overshoot region. The residence time for magnetic flux tubes with 2 × 1021 Mx in the convective overshoot layer can be comparable to the dynamo amplification time, provided that the average speed and the duration of an external downflow do not exceed about 50 m s -1 and 100 days, respectively, and that the lateral extension of the flow is smaller than about 10°. Appendix C and movies are only available in electronic form at http://www.aanda.org

Design of Multistage Axial-Flow Compressors

NASA Technical Reports Server (NTRS)

Crouse, J. E.; Gorrell, W. T.

1983-01-01

Program developed for computing aerodynamic design of multistage axialflow compressor and associated blading geometry input for internal flow analysis. Aerodynamic solution gives velocity diagrams on selected streamlines of revolution at blade row edges. Program written in FORTRAN IV.

Stability results for multi-layer radial Hele-Shaw and porous media flows

NASA Astrophysics Data System (ADS)

Gin, Craig; Daripa, Prabir

2015-01-01

Motivated by stability problems arising in the context of chemical enhanced oil recovery, we perform linear stability analysis of Hele-Shaw and porous media flows in radial geometry involving an arbitrary number of immiscible fluids. Key stability results obtained and their relevance to the stabilization of fingering instability are discussed. Some of the key results, among many others, are (i) absolute upper bounds on the growth rate in terms of the problem data; (ii) validation of these upper bound results against exact computation for the case of three-layer flows; (iii) stability enhancing injection policies; (iv) asymptotic limits that reduce these radial flow results to similar results for rectilinear flows; and (v) the stabilizing effect of curvature of the interfaces. Multi-layer radial flows have been found to have the following additional distinguishing features in comparison to rectilinear flows: (i) very long waves, some of which can be physically meaningful, are stable; and (ii) eigenvalues can be complex for some waves depending on the problem data, implying that the dispersion curves for one or more waves can contact each other. Similar to the rectilinear case, these results can be useful in providing insight into the interfacial instability transfer mechanism as the problem data are varied. Moreover, these can be useful in devising smart injection policies as well as controlling the complexity of the long-term dynamics when drops of various immiscible fluids intersperse among each other. As an application of the upper bound results, we provide stabilization criteria and design an almost stable multi-layer system by adding many layers of fluid with small positive jumps in viscosity in the direction of the basic flow.

Distribution of iron oxide core-titanium dioxide shell nanoparticles in VX2 tumor bearing rabbits introduced by two different delivery modalities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Refaat, Tamer; West, Derek; El Achy, Samar

This work compares intravenous (IV) versus fluoroscopy-guided transarterial intra-catheter (IC) delivery of iron oxide core-titanium dioxide shell nanoparticles (NPs) in vivo in VX2 model of liver cancer in rabbits. NPs coated with glucose and decorated with a peptide sequence from cortactin were administered to animals with developed VX2 liver cancer. Two hours after NPs delivery tumors, normal liver, kidney, lung and spleen tissues were harvested and used for a series on histological and elemental analysis tests. Quantification of NPs in tissues was done both by bulk inductively coupled plasma mass spectrometry (ICP-MS) analysis and by hard X-ray fluorescence microscopy. Bothmore » IV and IC NPs injection are feasible modalities for delivering NPs to VX2 liver tumors with comparable tumor accumulation. It is possible that this is an outcome of the fact that VX2 tumors are highly vascularized and hemorrhagic, and therefore enhanced permeability and retention (EPR) plays the most significant role in accumulation of nanoparticles in tumor tissue. It is, however, interesting to note that IV delivery led to increased sequestration of NPs by spleen and normal liver tissue, while IC delivery lead to more NP positive Kupffer cells. Furthermore, this difference is most likely a direct outcome of blood flow dynamics. Armed with this knowledge about nanoparticle delivery, we plan to test them as radiosensitizers in the future.« less

Distribution of iron oxide core-titanium dioxide shell nanoparticles in VX2 tumor bearing rabbits introduced by two different delivery modalities

DOE PAGES

Refaat, Tamer; West, Derek; El Achy, Samar; ...

2016-08-03

This work compares intravenous (IV) versus fluoroscopy-guided transarterial intra-catheter (IC) delivery of iron oxide core-titanium dioxide shell nanoparticles (NPs) in vivo in VX2 model of liver cancer in rabbits. NPs coated with glucose and decorated with a peptide sequence from cortactin were administered to animals with developed VX2 liver cancer. Two hours after NPs delivery tumors, normal liver, kidney, lung and spleen tissues were harvested and used for a series on histological and elemental analysis tests. Quantification of NPs in tissues was done both by bulk inductively coupled plasma mass spectrometry (ICP-MS) analysis and by hard X-ray fluorescence microscopy. Bothmore » IV and IC NPs injection are feasible modalities for delivering NPs to VX2 liver tumors with comparable tumor accumulation. It is possible that this is an outcome of the fact that VX2 tumors are highly vascularized and hemorrhagic, and therefore enhanced permeability and retention (EPR) plays the most significant role in accumulation of nanoparticles in tumor tissue. It is, however, interesting to note that IV delivery led to increased sequestration of NPs by spleen and normal liver tissue, while IC delivery lead to more NP positive Kupffer cells. Furthermore, this difference is most likely a direct outcome of blood flow dynamics. Armed with this knowledge about nanoparticle delivery, we plan to test them as radiosensitizers in the future.« less

40 CFR 60.103a - Design, equipment, work practice or operational standards.

Code of Federal Regulations, 2014 CFR

2014-07-01

...) Description and simple process flow diagram showing the interconnection of the following components of the... rate. (iv) Description and simple process flow diagram showing all gas lines (including flare, purge... which lines are monitored and identify on the process flow diagram the location and type of each monitor...

40 CFR 60.103a - Design, equipment, work practice or operational standards.

Code of Federal Regulations, 2013 CFR

2013-07-01

...) Description and simple process flow diagram showing the interconnection of the following components of the... rate. (iv) Description and simple process flow diagram showing all gas lines (including flare, purge... which lines are monitored and identify on the process flow diagram the location and type of each monitor...

Point-of-care detection and real-time monitoring of intravenously delivered drugs via tubing with an integrated SERS sensor

NASA Astrophysics Data System (ADS)

Wu, Hsin-Yu; Cunningham, Brian T.

2014-04-01

We demonstrate an approach for detection, identification, and kinetic monitoring of drugs flowing within tubing, through the use of a plasmonic nanodome array (PNA) surface. The PNA structures are fabricated using a low-cost nanoreplica molding process upon a flexible plastic substrate that is subsequently integrated with a flow cell that connects in series with ordinary intravenous (IV) drug delivery tubing. To investigate the potential clinical applications for point-of-care detection and real-time monitoring, we perform SERS detection of ten pharmaceutical compounds (hydrocodone, levorphanol, morphine, oxycodone, methadone, phenobarbital, dopamine, diltiazem, promethazine, and mitoxantrone). We demonstrate dose-dependent SERS signal magnitude, resulting in detection limits (ng ml-1) well below typical administered dosages (mg ml-1). Further, we show that the detected drugs are not permanently attached to the PNA surface, and thus our approach is capable of performing continuous monitoring of drug delivery as materials flow through IV tubing that is connected in series with the sensor. Finally, we demonstrate the potential co-detection of multiple drugs when they are mixed together, and show excellent reproducibility and stability of SERS measurements for periods extending at least five days. The capabilities reported here demonstrate the potential to use PNA SERS surfaces for enhancing the safety of IV drug delivery.We demonstrate an approach for detection, identification, and kinetic monitoring of drugs flowing within tubing, through the use of a plasmonic nanodome array (PNA) surface. The PNA structures are fabricated using a low-cost nanoreplica molding process upon a flexible plastic substrate that is subsequently integrated with a flow cell that connects in series with ordinary intravenous (IV) drug delivery tubing. To investigate the potential clinical applications for point-of-care detection and real-time monitoring, we perform SERS detection of ten pharmaceutical compounds (hydrocodone, levorphanol, morphine, oxycodone, methadone, phenobarbital, dopamine, diltiazem, promethazine, and mitoxantrone). We demonstrate dose-dependent SERS signal magnitude, resulting in detection limits (ng ml-1) well below typical administered dosages (mg ml-1). Further, we show that the detected drugs are not permanently attached to the PNA surface, and thus our approach is capable of performing continuous monitoring of drug delivery as materials flow through IV tubing that is connected in series with the sensor. Finally, we demonstrate the potential co-detection of multiple drugs when they are mixed together, and show excellent reproducibility and stability of SERS measurements for periods extending at least five days. The capabilities reported here demonstrate the potential to use PNA SERS surfaces for enhancing the safety of IV drug delivery. Electronic supplementary information (ESI) available: Fabrication of PNA substrates, fabrication details of the flow cell, details of FDTD simulation, characterization of the scattering volume, and detection of diltiazem diluted in DI water and PBS. See DOI: 10.1039/c4nr00027g

Hot-spot evolution and the global tectonics of venus.

PubMed

Phillips, R J; Grimm, R E; Malin, M C

1991-05-03

The global tectonics of Venus may be dominated by plumes rising from the mantle and impinging on the lithosphere, giving rise to hot spots. Global sea-floor spreading does not take place, but direct convective coupling of mantle flow fields to the lithosphere leads to regional-scale deformation and may allow lithospheric transport on a limited scale. A hot-spot evolutionary sequence comprises (i) a broad domal uplift resulting from a rising mantle plume, (ii) massive partial melting in the plume head and generation of a thickened crust or crustal plateau, (iii) collapse of dynamic topography, and (iv) creep spreading of the crustal plateau. Crust on Venus is produced by gradual vertical differentiation with little recycling rather than by the rapid horizontal creation and consumption characteristic of terrestrial sea-floor spreading.

Dynamic Contrast Enhanced MRI in Patients With Advanced Breast or Pancreatic Cancer With Metastases to the Liver or Lung

ClinicalTrials.gov

2014-05-28

Acinar Cell Adenocarcinoma of the Pancreas; Duct Cell Adenocarcinoma of the Pancreas; Liver Metastases; Lung Metastases; Recurrent Breast Cancer; Recurrent Pancreatic Cancer; Stage IV Breast Cancer; Stage IV Pancreatic Cancer

Crystal and Morphological Phase Transformation of Pb(II) to Pb(IV) in Chlorinated Water

EPA Science Inventory

Herein, we show that an important transformation of Pb(II) to Pb(IV) under laboratory conditions which is intended to represent in real water flowing system in lead pipes. These results will give an insight in understanding the scale formation in lead pipes and dissolution of lea...

Substance P and neurokinin A metabolism by cultured human skeletal muscle myocytes and fibroblasts.

PubMed

Russell, J S; Chi, H; Lantry, L E; Stephens, R E; Ward, P E

1996-01-01

A recent study determined that cultured human skeletal muscle adult myoblasts, myotubes, and fibroblasts degraded angiotensins and kinins via neutral endopeptidase-24.11 (NEP-24.11: EC 3.4.24.11) and aminopeptidase N (APN: EC 3.4.11.2). Due to the possible importance of other peptides to skeletal muscle blood flow and function, the present study looked specifically at the metabolism of the neurokinins substance P (SP) and neurokinin A (NKA) by skeletal muscle peptidases. The results show that SP is degraded not only by NEP-24.11, but also sequentially by dipeptidyl(amino)peptidase IV (DAP IV: EC 3.4.14.5)/APN. NKA is unaffected by DAP IV but is metabolized by NEP-24.11 and APN. NEP-24.11 was inhibited by phosphoramidon (IC50 = 80 nM), thiorphan and ZINCOV, DAP IV by diprotin A (IC50 = 8 microM), and APN by amastatin (IC50 = 50 nM) and bestatin (IC50 = 100 microM). Skeletal muscle myocyte and fibroblast metabolism of SP and NKA may regulate local skeletal muscle vascular and extravascular functions including SP- and NKA-mediated nerve-induced vasodilation. Inhibition of both NEP-24.11 and DAP IV/APN may increase skeletal muscle blood flow and decrease peripheral vascular resistance via potentiation of local neurokinin levels.

Intravenous nicorandil versus adenosine for fractional flow reserve measurement: a crossover, randomized study.

PubMed

Nishi, Takeshi; Kitahara, Hideki; Fujimoto, Yoshihide; Nakayama, Takashi; Nagashima, Kengo; Hanaoka, Hideki; Kobayashi, Yoshio

2018-06-01

Nicorandil has vasodilatory effects on both the epicardial coronary arteries and the coronary microvasculature, thereby increasing coronary blood flow. The objective of the present study was to investigate the effectiveness of intravenous (IV) nicorandil infusion for fractional flow reserve (FFR) measurement. In this crossover randomized study, 49 patients underwent FFR measurement with a consecutive randomized order of patient-blind infusions of continuous IV adenosine administration and a single bolus IV administration of nicorandil. The primary endpoint was the difference between the FFR by nicorandil and the FFR by adenosine, as assessed by the Bland-Altman method. The mean FFR value measured by nicorandil was not significantly different from that measured by adenosine [0.8125 ± 0.1349 vs. 0.7978 ± 0.124; mean difference, 0.0147 (95% confidence interval - 0.0373, 0.0667); P = 0.58]. There was no clinically significant diagnostic discordance, with the FFR by nicorandil > 0.80 and that by adenosine < 0.75. Hyperemia was achieved earlier using nicorandil than adenosine (34 ± 13 vs. 58 ± 15, P < 0.001). The duration of hyperemia after IV nicorandil was variable (6-570 s, mean 89 ± 98 s). IV nicorandil decreased systolic blood pressure by 32 ± 16 mm Hg (24 ± 10%) from baseline. Linear regression analysis showed that the average FFR value and the difference in systolic blood pressure were significantly associated with the bias in the FFR value between the two drugs. In conclusions, the results of the present study suggest that IV nicorandil can achieve maximal hyperemia easily and rapidly, providing an acceptable diagnostic performance for FFR assessment. However, a wide range of variation in hyperemic plateau and a decrease in blood pressure are the major limitations of this method.

Computational modeling of lava domes using particle dynamics to investigate the effect of conduit flow mechanics on flow patterns

NASA Astrophysics Data System (ADS)

Husain, Taha Murtuza

Large (1--4 x 106 m3) to major (> 4 x 106 m3) dome collapses for andesitic lava domes such as Soufriere Hills Volcano, Montserrat are observed for elevated magma discharge rates (6--13 m3/s). The gas rich magma pulses lead to pressure build up in the lava dome that result in structural failure of the over steepened canyon-like walls which may lead to rockfall or pyroclastic flow. This indicates that dome collapse intimately related to magma extrusion rate. Variation in magma extrusion rate for open-system magma chambers is observed to follow alternating periods of high and low activity. Periodic behavior of magma exhibits a rich diversity in the nature of its eruptive history due to variation in magma chamber size, total crystal content, linear crystal growth rate and magma replenishment rate. Distinguished patterns of growth were observed at different magma flow rates ranging from endogenous to exogenous dome growth for magma with varying strengths. Determining the key parameters that control the transition in flow pattern of the magma during its lava dome building eruption is the main focus. This dissertation examines the mechanical effects on the morphology of the evolving lava dome on the extrusion of magma from a central vent using a 2D particle dynamics model. The particle dynamics model is coupled with a conduit flow model that incorporates the kinetics of crystallization and rheological stiffening to investigate important mechanisms during lava dome building eruptions. Chapter I of this dissertation explores lava dome growth and failure mechanics using a two-dimensional particle-dynamics model. The model follows the evolution of fractured lava, with solidification driven by degassing induced crystallization of magma. The particle-dynamics model emulates the natural development of dome growth and rearrangement of the lava dome which is difficult in mesh-based analyses due to mesh entanglement effects. The deformable talus evolves naturally as a frictional carapace that caps a ductile magma core. Extrusion rate and magma rheology together with crystallization temperature and volatile content govern the distribution of strength in the composite structure. This new model is calibrated against existing observational models of lava dome growth. Chapter II of this dissertation explores the effects of a spectrum of different rheological regimes, on eruptive style and morphologic evolution of lava domes, using a two-dimensional (2D) particle-dynamics model for a spreading viscoplastic (Bingham) fluid. We assume that the ductile magma core of a 2-D synthetic lava dome develops finite yield strength, and that deformable frictional talus evolves from a carapace that caps the magma core. Our new model is calibrated against an existing analytical model for a spreading viscoplastic lava dome and is further compared against observational data of lava dome growth. Chapter III of this dissertation explores different lava-dome styles by developing a two-dimensional particle-dynamics model. These growth patterns range from endogenous lava dome growth comprising expansion of a ductile dome core to the exogenous extrusion of a degassed lava plug resulting in generation of a lava spine. We couple conduit flow dynamics with surface growth of the evolving lava dome, fueled by an open-system magma chamber undergoing continuous replenishment. The conduit flow model accounts for the variation in rheology of ascending magma that results from degassing-induced crystallization. Chapter IV of this dissertation explores the Variation in the extruding lava flow patterns range from endogenous dome growth with a ductile core to the exogenous extrusion of a degassed lava plug that results in the generation of a spine. The variations are a manifestation of the changes in the magma rheology which is governed by magma composition and rate of decompression of the ascending magma. We simulate using a two-dimensional particle-dynamics model, the cyclic behavior of lava dome growth with endogenous growth at high discharge rates followed by exogenous extrusion of rheologically stiffened lava due to degassing induced crystallization at low discharge rates. We couple conduit flow dynamics with surface growth of the evolving lava dome which is fueled by an overpressured reservoir undergoing constant replenishment. The periodic behavior between magma chamber pressure and discharge rate is reproduced as a result of the temporal and spatial change in magma viscosity controlled by crystallization kinetics. Dimensionless numbers are used to map the flow behaviors with the changing extrusion regime. A dimensionless plot identifying the flow transition region during the growth cycle of an evolving lava dome in its lava dome eruptive period is presented. The plot provides a the threshold value of a dimensionless strength parameter (pi 2 < 3.31 x 10-4) below which the transition in flow pattern occurs from endogenously evolving lava dome with a ductile core to the development of a shear lobe for short or long lived periodic episode of the extrusion of magma. (Abstract shortened by UMI.).

Dynamic power flow controllers

DOEpatents

Divan, Deepakraj M.; Prasai, Anish

2017-03-07

Dynamic power flow controllers are provided. A dynamic power flow controller may comprise a transformer and a power converter. The power converter is subject to low voltage stresses and not floated at line voltage. In addition, the power converter is rated at a fraction of the total power controlled. A dynamic power flow controller controls both the real and the reactive power flow between two AC sources having the same frequency. A dynamic power flow controller inserts a voltage with controllable magnitude and phase between two AC sources; thereby effecting control of active and reactive power flows between two AC sources.

Power loss for high-voltage solar-cell arrays

NASA Technical Reports Server (NTRS)

Parker, L. W.

1979-01-01

Electric field particle collection and power loss are calculated in program written in FORTRAN IV for use on UNIVAC 1100/40 computer. Program incorporates positive and negative and negative charge flows and balance between positive and negative flows is performed by iteration.

Evidence from simultaneous intracellular- and surface-pH transients that carbonic anhydrase IV enhances CO2 fluxes across Xenopus oocyte plasma membranes

PubMed Central

Occhipinti, Rossana; Boron, Walter F.

2014-01-01

Human carbonic anhydrase IV (CA IV) is GPI-anchored to the outer membrane surface, catalyzing CO2/HCO3− hydration-dehydration. We examined effects of heterologously expressed CA IV on intracellular-pH (pHi) and surface-pH (pHS) transients caused by exposing oocytes to CO2/HCO3−/pH 7.50. CO2 influx causes a sustained pHi fall and a transient pHS rise; CO2 efflux does the opposite. Both during CO2 addition and removal, CA IV increases magnitudes of maximal rate of pHi change (dpHi/dt)max, and maximal pHS change (ΔpHS) and decreases time constants for pHi changes (τpHi) and pHS relaxations (τpHS). Decreases in time constants indicate that CA IV enhances CO2 fluxes. Extracellular acetazolamide blocks all CA IV effects, but not those of injected CA II. Injected acetazolamide partially reduces CA IV effects. Thus, extracellular CA is required for, and the equivalent of cytosol-accessible CA augments, the effects of CA IV. Increasing the concentration of the extracellular non-CO2/HCO3− buffer (i.e., HEPES), in the presence of extracellular CA or at high [CO2], accelerates CO2 influx. Simultaneous measurements with two pHS electrodes, one on the oocyte meridian perpendicular to the axis of flow and one downstream from the direction of extracellular-solution flow, reveal that the downstream electrode has a larger (i.e., slower) τpHS, indicating [CO2] asymmetry over the oocyte surface. A reaction-diffusion mathematical model (third paper in series) accounts for the above general features, and supports the conclusion that extracellular CA, which replenishes entering CO2 or consumes exiting CO2 at the extracellular surface, enhances the gradient driving CO2 influx across the cell membrane. PMID:24965590

Minimum oxygen flow needed for vital support during simulated post-cardiorespiratory arrest resuscitation.

PubMed

Sanz-Sanjosé, E; Ariño Irujo, J J; Sánchez Martín, C E; González Perrino, C; López-Timoneda, F

2016-05-01

According to the ERC and the AHA guidelines, FiO2 should be titrated to achieve an O2Sat ≥ 94%. The aim of this study was to determine the minimum oxygen flow and time needed to reach an FiO2 of 0.32 and 0.80 during post-cardiac arrest care. An experimental analysis was performed that consisted of a simulated post-cardiac arrest situation. Different resuscitators were tested and connected to an artificial lung: Mark IV, SPUR II, Revivator Res-Q, O-TWO. The oxygen flow levels tested were 2, 5, 10 and 15 lpm. Bonferroni and Mann-Whitney U tests were used. An FiO2 of 0.32 or more was obtained using any of the oxygen flow and resuscitators. Only the Mark IV achieved an FiO2 of 0.80 after a minimum of 75s ventilating with 2 or 5 lpm. Clinical and statistical differences (P<.05) were found: at 15 lpm it took 35s to reach an FiO2 of 0.80 or more for Mark IV (85.6 [0.3]) and Revivator (84.3 [1.5]) compared to 50s for SPUR II (87.1 [6.4]); at 2 lpm, all of the devices reached an FiO2 of ≥ 0.32 at 30s(Mark IV (34.8 [1.3]), Revivator (35.7 [1.5]) and SPUR II (34.4 [2.1]), except for O-TWO, which took 35s (36.3 [4.3]). Patients could be ventilated with any of the resuscitators using 2 lpm to obtain an FiO2 of 0.32, although possibly O-TWO would be the last option during the first 60s. In order to reach an FiO2 of 0.80, ventilating with 10 lpm should be sufficient, and preferably using Mark IV or Revivator Res-Q. In conclusion, on observing the results of our study, in any possible scenario, it would be advisable to use Revivator Res-Q or Mark IV rather than O-TWO or SPUR II. Copyright © 2015 Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Publicado por Elsevier España, S.L.U. All rights reserved.

AutoSyP: A Low-Cost, Low-Power Syringe Pump for Use in Low-Resource Settings.

PubMed

Juarez, Alexa; Maynard, Kelley; Skerrett, Erica; Molyneux, Elizabeth; Richards-Kortum, Rebecca; Dube, Queen; Oden, Z Maria

2016-10-05

This article describes the design and evaluation of AutoSyP, a low-cost, low-power syringe pump intended to deliver intravenous (IV) infusions in low-resource hospitals. A constant-force spring within the device provides mechanical energy to depress the syringe plunger. As a result, the device can run on rechargeable battery power for 66 hours, a critical feature for low-resource settings where the power grid may be unreliable. The device is designed to be used with 5- to 60-mL syringes and can deliver fluids at flow rates ranging from 3 to 60 mL/hour. The cost of goods to build one AutoSyP device is approximately $500. AutoSyP was tested in a laboratory setting and in a pilot clinical study. Laboratory accuracy was within 4% of the programmed flow rate. The device was used to deliver fluid to 10 healthy adult volunteers and 30 infants requiring IV fluid therapy at Queen Elizabeth Central Hospital in Blantyre, Malawi. The device delivered fluid with an average mean flow rate error of -2.3% ± 1.9% for flow rates ranging from 3 to 60 mL/hour. AutoSyP has the potential to improve the accuracy and safety of IV fluid delivery in low-resource settings. © The American Society of Tropical Medicine and Hygiene.

DSMC Simulation and Experimental Validation of Shock Interaction in Hypersonic Low Density Flow

PubMed Central

2014-01-01

Direct simulation Monte Carlo (DSMC) of shock interaction in hypersonic low density flow is developed. Three collision molecular models, including hard sphere (HS), variable hard sphere (VHS), and variable soft sphere (VSS), are employed in the DSMC study. The simulations of double-cone and Edney's type IV hypersonic shock interactions in low density flow are performed. Comparisons between DSMC and experimental data are conducted. Investigation of the double-cone hypersonic flow shows that three collision molecular models can predict the trend of pressure coefficient and the Stanton number. HS model shows the best agreement between DSMC simulation and experiment among three collision molecular models. Also, it shows that the agreement between DSMC and experiment is generally good for HS and VHS models in Edney's type IV shock interaction. However, it fails in the VSS model. Both double-cone and Edney's type IV shock interaction simulations show that the DSMC errors depend on the Knudsen number and the models employed for intermolecular interaction. With the increase in the Knudsen number, the DSMC error is decreased. The error is the smallest in HS compared with those in the VHS and VSS models. When the Knudsen number is in the level of 10−4, the DSMC errors, for pressure coefficient, the Stanton number, and the scale of interaction region, are controlled within 10%. PMID:24672360

Comparison of biofilm formation between major clonal lineages of methicillin resistant Staphylococcus aureus.

PubMed

Vanhommerig, Evelyn; Moons, Pieter; Pirici, Daniel; Lammens, Christine; Hernalsteens, Jean-Pierre; De Greve, Henri; Kumar-Singh, Samir; Goossens, Herman; Malhotra-Kumar, Surbhi

2014-01-01

Epidemic methicillin-resistant S. aureus (MRSA) clones cause infections in both hospital and community settings. As a biofilm phenotype further facilitates evasion of the host immune system and antibiotics, we compared the biofilm-forming capacities of various MRSA clones. Seventy-six MRSA classified into 13 clones (USA300, EMRSA-15, Hungarian/Brazilian etc.), and isolated from infections or from carriers were studied for biofilm formation under static and dynamic conditions. Static biofilms in microtitre plates were quantified colorimetrically. Dynamic biofilms (Bioflux 200, Fluxion, USA) were studied by confocal laser-scanning and time-lapse microscopy, and the total volume occupied by live/dead bacteria quantified by Volocity 5.4.1 (Improvision, UK). MRSA harbouring SCCmec IV produced significantly more biomass under static conditions than SCCmec I-III (P = 0.003), and those harbouring SCCmec II significantly less than those harbouring SCCmec I or III (P<0.001). In the dynamic model, SCCmec I-III harbouring MRSA were significantly better biofilm formers than SCCmec IV (P = 0.036). Only 16 strains successfully formed biofilms under both conditions, of which 13 harboured SCCmec IV and included all tested USA300 strains (n = 3). However, USA300 demonstrated remarkably lower percentages of cell-occupied space (6.6%) compared to the other clones (EMRSA-15 = 19.0%) under dynamic conditions. Time-lapse microscopy of dynamic biofilms demonstrated that USA300 formed long viscoelastic tethers that stretched far from the point of attachment, while EMRSA-15 consisted of micro-colonies attached densely to the surface. MRSA harbouring SCCmec types IV and I-III demonstrate distinct biofilm forming capacities, possibly owing to their adaptation to the community and hospital settings, respectively. USA300 demonstrated abundant biofilm formation under both conditions, which probably confers a competitive advantage, contributing to its remarkable success as a pathogen.

On the room-temperature phase diagram of high pressure hydrogen: an ab initio molecular dynamics perspective and a diffusion Monte Carlo study.

PubMed

Chen, Ji; Ren, Xinguo; Li, Xin-Zheng; Alfè, Dario; Wang, Enge

2014-07-14

The finite-temperature phase diagram of hydrogen in the region of phase IV and its neighborhood was studied using the ab initio molecular dynamics (MD) and the ab initio path-integral molecular dynamics (PIMD). The electronic structures were analyzed using the density-functional theory (DFT), the random-phase approximation, and the diffusion Monte Carlo (DMC) methods. Taking the state-of-the-art DMC results as benchmark, comparisons of the energy differences between structures generated from the MD and PIMD simulations, with molecular and dissociated hydrogens, respectively, in the weak molecular layers of phase IV, indicate that standard functionals in DFT tend to underestimate the dissociation barrier of the weak molecular layers in this mixed phase. Because of this underestimation, inclusion of the quantum nuclear effects (QNEs) in PIMD using electronic structures generated with these functionals leads to artificially dissociated hydrogen layers in phase IV and an error compensation between the neglect of QNEs and the deficiencies of these functionals in standard ab initio MD simulations exists. This analysis partly rationalizes why earlier ab initio MD simulations complement so well the experimental observations. The temperature and pressure dependencies for the stability of phase IV were also studied in the end and compared with earlier results.

Progress in understanding uranium(IV) speciation and dynamics in biologically reduced sediments: Research at molecular to centimeter scales by the SLAC SFA program

NASA Astrophysics Data System (ADS)

Bargar, J.; Williams, K. H.; Campbell, K. M.; Stubbs, J. E.; Suvorova, E.; Lezama-Pacheco, J. S.; Alessi, D.; Stylo, M.; Handley, K. M.; Bernier-Latmani, R.; Cerrato, J.; Davis, J. A.; Fox, P. M.; Giammar, D.; Long, P. E.

2011-12-01

The chemical and physical forms of U(IV) in reduced sediments, as well as the biogeochemical processes by which they form and transform, profoundly influence the stability of reduced U(IV) species and the behavior of uranium in biostimulated aquifers. Obtaining such information in field sediments is important because biogeochemical field conditions and their time dependence are difficult to replicate in the laboratory. The majority of contaminated aquifers in which bioremediation is of potential interest, including the Old Rifle, CO IFRC site, exhibit relatively low uranium sediment concentrations, i.e., < 10 ppm, presenting a formidable challenge to the use of spectroscopy and microscopy techniques that typically require 10-fold or higher uranium loadings. We have developed an in-situ column technique to study U(IV) species and evolving microbial communities in the Old Rifle aquifer and to correlate them with changes in trace and major ion groundwater composition during biostimulation treatments. Sediments were examined using x-ray and electron microscopy, x-ray absorption spectroscopy (XAS), and chemical extractions. XAS analysis showed that U(IV) occurred predominantly or exclusively as monomeric U(IV) complexes coordinated to oxo (or similar N/C) neighbors, and is associated with biomass or Fe sulfides. Even in the latter case, U(IV) was not coordinated directly to S neighbors. Sediment-hosted monomeric U(IV) complexes were found to partially transform into uraninite in the aquifer over a subsequent 12 month period. This work establishes the importance of monomeric U(IV) complexes in subsurface sediments at the Old Rifle site and provides a conceptual framework in which previously observed U(IV) reduction products can be related. These experiments also establish that U(IV) species are dynamic in aquifers and can undergo non-oxidative transformation reactions. These new results have important implications for uranium reactive transport models, long-term assessment of remediation technologies, and understanding natural uranium reduction in aquifers.

Dynamic evolution of recurrent mass ejections observed in H-alpha and C IV lines

NASA Technical Reports Server (NTRS)

Schmieder, B.; Mein, P.; Martres, M. J.; Tandberg-Hanssen, E.

1984-01-01

The mass ejections of 1 September, 1980 are studied from observations obtained with the MSDP spectrograph and with the Ultraviolet Spectrometer and Polarimeter aboard the Solar Maximum Mission satellite. The analysis is focused on observations in the chromospheric H-alpha line and the transition region C IV 1548 A line. It is noted that cold and hot material had the same projection, although the upward C IV velocity structure was more extended than the H-alpha one. It is shown that the observed contrast of the H-alpha absorbing structure can be interpreted in terms of a dynamic cloud model overlying the chromosphere. Radial velocities of 25-30 km/s and -40 km/s are estimated for the first and second phases of ejection, respectively.

Investigations of the Application of CFD to Flow Expected in the Lower Plenum of the Prismatic VHTR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Richard W.Johnson; Tara Gallaway; Donna P. Guillen

2006-09-01

The Generation IV (Gen IV) very high temperature reactor (VHTR) will either be a prismatic (block) or pebble bed design. However, a prismatic VHTR reference design, based on the General Atomics Gas Turbine-Modular Helium Reactor (GT-MHR) [General Atomics, 1996] has been developed for preliminary analysis purposes [MacDonald, et al., 2003]. Numerical simulation studies reported herein are based on this reference design. In the lower plenum of the prismatic reference design, the flow will be introduced by dozens of turbulent jets from the core above. The jet flow will encounter rows of columns that support the core. The flow from themore » core will have to turn ninety degrees and flow toward the exit duct as it passed through the forest of support columns. Due to the radial variation of the power density in the core, the jets will be at various temperatures at the inlet to the lower plenum. This presents some concerns, including that local hot spots may occur in the lower plenum. This may have a deleterious effect on the materials present as well as cause a variation in temperature to be present as the flow enters the power conversion system machinery, which could cause problems with the operation of the machinery. In the past, systems analysis codes have been used to model flow in nuclear reactor systems. It is recognized, however, that such codes are not capable of modeling the local physics of the flow to be able to analyze for local mixing and temperature variations. This has led to the determination that computational fluid dynamic (CFD) codes be used, which are generally regarded as having the capability of accurately simulating local flow physics. Accurate flow modeling involves determining appropriate modeling strategies needed to obtain accurate analyses. These include determining the fineness of the grid needed, the required iterative convergence tolerance, which numerical discretization method to use, and which turbulence model and wall treatment should be employed. It also involves validating the computer code and turbulence model against a series of separate and combined flow phenomena and selecting the data used for the validation. This report describes progress made to identify proper modeling strategies for simulating the lower plenum flow for the task entitled “CFD software validation of jets in crossflow,” which was designed to investigate the issues pertaining to the validation process. The flow phenomenon previously chosen to investigate is flow in a staggered tube bank because it is shown by preliminary simulations to be the location of the highest turbulence intensity in the lower plenum Numerical simulations were previously obtained assuming that the flow is steady. Various turbulence models were employed along with strategies to reduce numerical error to allow appropriate comparisons of the results. It was determined that the sophisticated Reynolds stress model (RSM) provided the best results. It was later determined that the flow is an unsteady flow wherein circulating eddies grow behind the tube and ‘peel off’ alternately from the top and the bottom of the tube. Additional calculations show that the mean velocity is well predicted when the flow is modeled as an unsteady flow. The results for U are clearly superior for the unsteady computations; the unsteady computations for the turbulence stress are similar to those for the steady calculations, showing the same trends. It is clear that strategie« less

Evaluating the impact of water conservation on fate of outdoor water use: a study in an arid region.

PubMed

Qaiser, Kamal; Ahmad, Sajjad; Johnson, Walter; Batista, Jacimaria

2011-08-01

In this research, the impact of several water conservation policies and return flow credits on the fate of water used outdoors in an arid region is evaluated using system dynamics modeling approach. Return flow credits is a strategy where flow credits are obtained for treated wastewater returned to a water body, allowing for the withdrawal of additional water equal to the amount returned as treated wastewater. In the return credit strategy, treated wastewater becomes a resource. This strategy creates a conundrum in which conservation may lead to an apparent decrease in water supply because less wastewater is generated and returned to water body. The water system of the arid Las Vegas Valley in Nevada, USA is used as basis for the dynamic model. The model explores various conservation scenarios to attain the daily per capita demand target of 752 l by 2035: (i) status quo situation where conservation is not implemented, (ii) conserving water only on the outdoor side, (iii) conserving water 67% outdoor and 33% indoor, (iv) conserving equal water both in the indoor and outdoor use (v) conserving water only on the indoor side. The model is validated on data from 1993 to 2008 and future simulations are carried out up to 2035. The results show that a substantial portion of the water used outdoor either evapo-transpires (ET) or infiltrates to shallow groundwater (SGW). Sensitivity analysis indicated that seepage to groundwater is more susceptible to ET compared to any other variable. The all outdoor conservation scenario resulted in the highest return flow credits and the least ET and SGW. A major contribution of this paper is in addressing the water management issues that arise when wastewater is considered as a resource and developing appropriate conservation policies in this backdrop. The results obtained can be a guide in developing outdoor water conservation policies in arid regions. Copyright © 2011 Elsevier Ltd. All rights reserved.

Assessing when chromosomal rearrangements affect the dynamics of speciation: implications from computer simulations

PubMed Central

Feder, Jeffrey L.; Nosil, Patrik; Flaxman, Samuel M.

2014-01-01

Many hypotheses have been put forth to explain the origin and spread of inversions, and their significance for speciation. Several recent genic models have proposed that inversions promote speciation with gene flow due to the adaptive significance of the genes contained within them and because of the effects inversions have on suppressing recombination. However, the consequences of inversions for the dynamics of genome wide divergence across the speciation continuum remain unclear, an issue we examine here. We review a framework for the genomics of speciation involving the congealing of the genome into alternate adaptive states representing species (“genome wide congealing”). We then place inversions in this context as examples of how genetic hitchhiking can potentially hasten genome wide congealing. Specifically, we use simulation models to (i) examine the conditions under which inversions may speed genome congealing and (ii) quantify predicted magnitudes of these effects. Effects of inversions on promoting speciation were most common and pronounced when inversions were initially fixed between populations before secondary contact and adaptation involved many genes with small fitness effects. Further work is required on the role of underdominance and epistasis between a few loci of major effect within inversions. The results highlight five important aspects of the roles of inversions in speciation: (i) the geographic context of the origins and spread of inversions, (ii) the conditions under which inversions can facilitate divergence, (iii) the magnitude of that facilitation, (iv) the extent to which the buildup of divergence is likely to be biased within vs. outside of inversions, and (v) the dynamics of the appearance and disappearance of exceptional divergence within inversions. We conclude by discussing the empirical challenges in showing that inversions play a central role in facilitating speciation with gene flow. PMID:25206365

40 CFR 63.7741 - What are the installation, operation, and maintenance requirements for my monitors?

Code of Federal Regulations, 2010 CFR

2010-07-01

... paragraphs (a)(1)(i) through (iv) of this section. (i) Locate the flow sensor and other necessary equipment... sensor with a minimum measurement sensitivity of 2 percent of the flow rate. (iii) Conduct a flow sensor... paragraphs (a)(2)(i) through (vi) of this section. (i) Locate the pressure sensor(s) in or as close as...

40 CFR 63.7741 - What are the installation, operation, and maintenance requirements for my monitors?

Code of Federal Regulations, 2012 CFR

2012-07-01

... paragraphs (a)(1)(i) through (iv) of this section. (i) Locate the flow sensor and other necessary equipment... sensor with a minimum measurement sensitivity of 2 percent of the flow rate. (iii) Conduct a flow sensor... paragraphs (a)(2)(i) through (vi) of this section. (i) Locate the pressure sensor(s) in or as close as...

40 CFR 63.7741 - What are the installation, operation, and maintenance requirements for my monitors?

Code of Federal Regulations, 2014 CFR

2014-07-01

... paragraphs (a)(1)(i) through (iv) of this section. (i) Locate the flow sensor and other necessary equipment... sensor with a minimum measurement sensitivity of 2 percent of the flow rate. (iii) Conduct a flow sensor... paragraphs (a)(2)(i) through (vi) of this section. (i) Locate the pressure sensor(s) in or as close as...

Fast reactor safety and related physics. Volume IV. Phenomenology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1976-01-01

Separate abstracts are included for 58 papers concerning single-phase flow and sodium boiling; sodium boiling and subassembly flow blockages; transient-overpower and loss-of-flow experiments; fuel and cladding behavior and relocation; fuel and cladding freezing; molten-fuel-coolant interaction; aerosols and fission product release, and post-accident heat removal. Thirteen papers have been perivously abstracted and included in ERA.

An implementation of a chemical and thermal nonequilibrium flow solver on unstructured meshes and application to blunt bodies

NASA Technical Reports Server (NTRS)

Prabhu, Ramadas K.

1994-01-01

This paper presents a nonequilibrium flow solver, implementation of the algorithm on unstructured meshes, and application to hypersonic flow past blunt bodies. Air is modeled as a mixture of five chemical species, namely O2, N2, O, NO, and N, having two temperatures namely translational and vibrational. The solution algorithm is a cell centered, point implicit upwind scheme that employs Roe's flux difference splitting technique. Implementation of this algorithm on unstructured meshes is described. The computer code is applied to solve Mach 15 flow with and without a Type IV shock interference on a cylindrical body of 2.5mm radius representing a cowl lip. Adaptively generated meshes are employed, and the meshes are refined several times until the solution exhibits detailed flow features and surface pressure and heat flux distributions. Effects of a catalytic wall on surface heat flux distribution are studied. For the Mach 15 Type IV shock interference flow, present results showed a peak heat flux of 544 MW/m2 for a fully catalytic wall and 431 MW/m(exp 2) for a noncatalytic wall. Some of the results are compared with available computational data.

Quasi-one-dimensional compressible flow across face seals and narrow slots. 2: Computer program

NASA Technical Reports Server (NTRS)

Zuk, J.; Smith, P. J.

1972-01-01

A computer program is presented for compressible fluid flow with friction across face seals and through narrow slots. The computer program carries out a quasi-one-dimensional flow analysis which is valid for laminar and turbulent flows under both subsonic and choked flow conditions for parallel surfaces. The program is written in FORTRAN IV. The input and output variables are in either the International System of Units (SI) or the U.S. customary system.

30 CFR 816.43 - Diversions.

Code of Federal Regulations, 2010 CFR

2010-07-01

.... (a) General requirements. (1) With the approval of the regulatory authority, any flow from mined areas abandoned before May 3, 1978, and any flow from undisturbed areas or reclaimed areas, after... suspended solids to streamflow outside the permit area; and (iv) Comply with all applicable local, State...

U(VI) Reduction by Biogenic and Abiotic Hydroxycarbonate Green Rusts: Impacts on U(IV) Speciation and Stability Over Time

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yan, Sen; Boyanov, Maxim I.; Mishra, Bhoopesh

Green rusts (GRs) are redox active Fe II-Fe III minerals that form in the environment via various biotic and abiotic processes. Although both biogenic (BioGR) and abiotic (ChemGR) GRs have been shown to reduce U VI, the dynamics of the transformations and the speciation and stability of the resulting U IV phases are poorly understood. We used carbonate extraction and XAFS spectroscopy to investigate the products of U VI reduction by BioGR and ChemGR. The results show that both GRs can rapidly remove U VI from synthetic groundwater via reduction to U IV. The initial products in the ChemGR systemmore » are solids-associated U IV-carbonate complexes that gradually transform to nanocrystalline uraninite over time, leading to a decrease in the proportion of carbonate-extractable U from ~95% to ~10%. In contrast, solid-phase U IV atoms in the BioGR system remain relatively extractable, non-uraninite U IV species over the same reaction period. The presence of calcium and carbonate in groundwater significantly increase the extractability of U IV in the BioGR system. Furthermore, these data provide new insights into the transformations of U under anoxic conditions in groundwater that contains calcium and carbonate, and have major implications for predicting uranium stability within redox dynamic environments and designing approaches for the remediation of uranium-contaminated groundwater.« less

U(VI) Reduction by Biogenic and Abiotic Hydroxycarbonate Green Rusts: Impacts on U(IV) Speciation and Stability Over Time

DOE PAGES

Yan, Sen; Boyanov, Maxim I.; Mishra, Bhoopesh; ...

2018-04-09

Green rusts (GRs) are redox active Fe II-Fe III minerals that form in the environment via various biotic and abiotic processes. Although both biogenic (BioGR) and abiotic (ChemGR) GRs have been shown to reduce U VI, the dynamics of the transformations and the speciation and stability of the resulting U IV phases are poorly understood. We used carbonate extraction and XAFS spectroscopy to investigate the products of U VI reduction by BioGR and ChemGR. The results show that both GRs can rapidly remove U VI from synthetic groundwater via reduction to U IV. The initial products in the ChemGR systemmore » are solids-associated U IV-carbonate complexes that gradually transform to nanocrystalline uraninite over time, leading to a decrease in the proportion of carbonate-extractable U from ~95% to ~10%. In contrast, solid-phase U IV atoms in the BioGR system remain relatively extractable, non-uraninite U IV species over the same reaction period. The presence of calcium and carbonate in groundwater significantly increase the extractability of U IV in the BioGR system. Furthermore, these data provide new insights into the transformations of U under anoxic conditions in groundwater that contains calcium and carbonate, and have major implications for predicting uranium stability within redox dynamic environments and designing approaches for the remediation of uranium-contaminated groundwater.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Despotopulos, John D.; Kmak, Kelly N.; Gharibyan, Narek

Eichrom’s Pb resin, a crown-ether-based extraction chromatography resin, was characterized for separation of the flerovium (Fl) homologs, Pb and Sn. Batch uptake of Pb(II) and Sn(IV) radionuclides was determined from an HNO 3 matrix. Pb(II) was strongly retained on the resin at all HNO 3 concentrations, while Sn(IV) showed no uptake. Extraction kinetics for Pb(II) were examined and show suitable uptake on the second time scale. Here, separation methods for the isolation of individual homologs, Pb(II) and Sn(IV), have been established using 2 mL pre-packed vacuum flow Pb resin columns.

Effects of fenoldopam on renal blood flow in hypertensive chronic kidney disease.

PubMed

Rovella, Valentina; Ferrannini, Michele; Tesauro, Manfredi; Marrone, Giulia; Busca, Andrea; Sorge, Roberto; Manca di Villahermosa, Simone; Casasco, Maurizio; Di Daniele, Nicola; Noce, Annalisa

2018-05-15

The synthetic drug fenoldopam mesylate (FM) may have a renoprotective role, and a "renal dose" of 0.1 µg/kg/min intravenous (IV) infusion of FM has been reported as able to increase renal blood flow without affecting systemic blood pressure. But conclusive data are still lacking. We aimed to investigate by color-Doppler ultrasonography the effects of IV administration of FM at this dosage in hypertensive chronic kidney disease (CKD) patients, and verify whether it may induce any systemic hemodynamic alteration. In 60 hypertensive CKD patients, we measured by duplex Doppler ultrasonography, at baseline and during infusion of 0.1 µg/kg/min of FM, the systolic and diastolic flow velocity (sampled at the renal hilum, intermediate section and origin of both renal arteries) and the intra-parenchymal renal resistive index (RRI) sampled on interlobular arteries of both kidneys. Patients were divided into four subgroups (I-IV) according to classification of National Kidney Foundation Kidney Disease Outcomes Quality Initiative (NKF-DOQI). Infusion of 0.1 µg/kg/min FM significantly decreased the RRI (0.73 ± 0.05 vs. 0.65 ± 0.06; p < 0.0001) and increased the systolic and diastolic flow velocities in all renal artery tracts examined. No single episode of systemic hypotension was observed. Very low-dose FM may significantly increase renal blood flow and exert a renal protective effect in hypertensive CKD patients. Infusion of FM at such low dosage appears also to be quite safe, even in CKD and hypertensive patients.

The role of Ce(III) in BZ oscillating reactions

NASA Astrophysics Data System (ADS)

Nogueira, Paulo A.; Varela, Hamilton; Faria, Roberto B.

2012-03-01

Herein we present results on the oscillatory dynamics in the bromate-oxalic acid-acetone-Ce(III)/Ce(IV) system in batch and also in a CSTR. We show that Ce(III) is the necessary reactant to allow the emergence of oscillations. In batch, oscillations occur with Ce(III) and also with Ce(IV), but no induction period is observed with Ce(III). In a CSTR, no oscillations were found using a freshly prepared Ce(IV), but only when the cerium-containing solution was aged, allowing partial conversion of Ce(IV) to Ce(III) by reaction with acetone.

Two-electron high potential and high capacity redox active molecules for energy storage applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huang, Jinhua; Zhang, Lu; Burrell, Anthony K.

A non-aqueous redox flow battery includes a catholyte including a compound of formula (I), a compound of formula (II), or a compound of formula (III): ##STR00001## wherein two R groups have the formula X, wherein X is X, wherein X is a group of formula IV-A or IV-B; ##STR00002##

Influence of Membrane Equivalent Weight and Reinforcement on Ionic Species Crossover in All-Vanadium Redox Flow Batteries.

PubMed

Ashraf Gandomi, Yasser; Aaron, Doug S; Mench, Matthew M

2017-06-06

One of the major sources of lost capacity in all-vanadium redox flow batteries (VRFBs) is the undesired transport (usually called crossover) of water and vanadium ions through the ion-exchange membrane. In this work, an experimental assessment of the impact of ion-exchange membrane properties on vanadium ion crossover and capacity decay of VRFBs has been performed. Two types of cationic membranes (non-reinforced and reinforced) with three equivalent weights of 800, 950 and 1100 g·mol -1 were investigated via a series of in situ performance and capacity decay tests along with ex situ vanadium crossover measurement and membrane characterization. For non-reinforced membranes, increasing the equivalent weight (EW) from 950 to 1100 g·mol -1 decreases the V(IV) permeability by ~30%, but increases the area-specific resistance (ASR) by ~16%. This increase in ASR and decrease in V(IV) permeability was accompanied by increased through-plane membrane swelling. Comparing the non-reinforced with reinforced membranes, membrane reinforcement increases ASR, but V(IV) permeability decreases. It was also shown that there exists a monotonic correlation between the discharge capacity decay over long-term cycling and V(IV) permeability values. Thus, V(IV) permeability is considered a representative diagnostic for assessing the overall performance of a particular ion-exchange membrane with respect to capacity fade in a VRFB.

Influence of Membrane Equivalent Weight and Reinforcement on Ionic Species Crossover in All-Vanadium Redox Flow Batteries

PubMed Central

Ashraf Gandomi, Yasser; Aaron, Doug S.; Mench, Matthew M.

2017-01-01

One of the major sources of lost capacity in all-vanadium redox flow batteries (VRFBs) is the undesired transport (usually called crossover) of water and vanadium ions through the ion-exchange membrane. In this work, an experimental assessment of the impact of ion-exchange membrane properties on vanadium ion crossover and capacity decay of VRFBs has been performed. Two types of cationic membranes (non-reinforced and reinforced) with three equivalent weights of 800, 950 and 1100 g·mol−1 were investigated via a series of in situ performance and capacity decay tests along with ex situ vanadium crossover measurement and membrane characterization. For non-reinforced membranes, increasing the equivalent weight (EW) from 950 to 1100 g·mol−1 decreases the V(IV) permeability by ~30%, but increases the area-specific resistance (ASR) by ~16%. This increase in ASR and decrease in V(IV) permeability was accompanied by increased through-plane membrane swelling. Comparing the non-reinforced with reinforced membranes, membrane reinforcement increases ASR, but V(IV) permeability decreases. It was also shown that there exists a monotonic correlation between the discharge capacity decay over long-term cycling and V(IV) permeability values. Thus, V(IV) permeability is considered a representative diagnostic for assessing the overall performance of a particular ion-exchange membrane with respect to capacity fade in a VRFB. PMID:28587268

Non-equilibrium character of resistive switching and negative differential resistance in Ga-doped Cr2O3 system

NASA Astrophysics Data System (ADS)

Bhowmik, R. N.; Siva, K. Venkata

2018-07-01

The samples of Ga-doped Cr2O3 system in rhombohedral crystal structure with space group R 3 bar C were prepared by chemical co-precipitation route and annealing at 800 °C. The current-voltage (I-V) curves exhibited many unique non-linear properties, e.g., hysteresis loop, resistive switching, and negative differential resistance (NDR). In this work, we report non-equilibrium properties of resistive switching and NDR phenomena. The non-equilibrium I-V characteristics were confirmed by repetiting measurement and time relaxation of current. The charge conduction process was understood by analysing the I-V curves using electrode-limited and bulk-limited charge conduction mechanisms, which were proposed for metal electrode/metal oxide/metal electrode structure. The I-V curves in the NDR regime and at higher bias voltage regime in our samples did not obey Fowler-Nordheim equation, which was proposed for charge tunneling mechanism in many thin film junctions. The non-equilibrium I-V phenomena were explained by considering the competitions between the injection of charge carriers from metal electrode to metal oxide, the charge flow through bulk material mediated by trapping/de-trapping and recombination of charge carriers at the defect sites of ions, the space charge effects at the junctions of electrodes and metal oxides, and finally, the out flow of electrons from metal oxide to metal electrode.

Probing the central engine and environment of AGN using ARIES 1.3-m and 3.6-m telescopes

NASA Astrophysics Data System (ADS)

Chand, Hum; Rakshit, Suvendu; Jalan, Priyanka; Ojha, Vineet; Srianand, Raghunathan; Vivek, Mariappan; Mishra, Sapna; Omar, Amitesh; Kumar, Parveen; Joshi, Ravi; Gopal-Krishna; Kumar, Rathna

2018-04-01

We discuss three long term observational programmes to probe the central engine and environment of active galactic nuclei (AGN) using the recently installed ARIES 1.3-m and 3.6-m telescopes. The first programme is on the photometric reverberation mapping of low luminosity AGN by mainly using the ARIES 1.3-m telescope. The major impact of this programme other than to estimate the black hole mass will be to extend the broad line region (BLR) radius-luminosity (RBLR-LAGN) relation to the unexplored low luminosity regime, and to constrain the AGN broad line region geometry. The second programme is to use long slit spectroscopy on the ARIES 3.6-m telescope to discover new high redshift quasar pairs with angular separation less than 1-arcmin. Here, the background QSOs sight-line will be used to probe the environment of the foreground QSOs at kpc-Mpc scales. The major impact of this programme will be on the discovery of new pairs which have been missed in the SDSS survey due to fiber collision below 1-arcmin separation, and use them to understand about any excess overdensity around the QSO, any anisotropic emission of QSOs, and/or any episodic activity of QSOs. The third programme is related to spectral variability studies of the C IV broad absorption line (BAL) QSOs, based on low resolution spectroscopy using the ARIES 3.6-m telescope. Here, those most interesting cases will be monitored, where the BAL flow emerges afresh or disappears completely in the C IV trough of BAL QSOs sample as seen in SDSS multi-epoch observations. Continuous monitoring of such a sample will be important for our understanding of the nature and origin of the flow, along with their stability and dynamical evolution.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pauzi, Anas Muhamad, E-mail: Anas@uniten.edu.my; Cioncolini, Andrea; Iacovides, Hector

The Molten Salt Reactor (MSR) is one of the most promising system proposed by Generation IV Forum (GIF) for future nuclear reactor systems. Advantages of the MSR are significantly larger compared to other reactor system, and is mainly achieved from its liquid nature of fuel and coolant. Further improvement to this system, which is a natural circulating molten fuel salt inside its tube in the reactor core is proposed, to achieve advantages of reducing and simplifying the MSR design proposed by GIF. Thermal hydraulic analysis on the proposed system was completed using a commercial computation fluid dynamics (CFD) software calledmore » FLUENT by ANSYS Inc. An understanding on theory behind this unique natural circulation flow inside the tube caused by fission heat generated in molten fuel salt and tube cooling was briefly introduced. Currently, no commercial CFD software could perfectly simulate natural circulation flow, hence, modeling this flow problem in FLUENT is introduced and analyzed to obtain best simulation results. Results obtained demonstrate the existence of periodical transient nature of flow problem, hence improvements in tube design is proposed based on the analysis on temperature and velocity profile. Results show that the proposed system could operate at up to 750MW core power, given that turbulence are enhanced throughout flow region, and precise molten fuel salt physical properties could be defined. At the request of the authors and the Proceedings Editor the name of the co-author Andrea Cioncolini was corrected from Andrea Coincolini. The same name correction was made in the Acknowledgement section on page 030004-10 and in reference number 4. The updated article was published on 11 May 2015.« less

Microbial Reduction of Fe(III) and U(VI) in Aquifers: Simulations Exploring Coupled Effects of Heterogeneity and Fe(II) Sorption

NASA Astrophysics Data System (ADS)

Scheibe, T. D.; Fang, Y.; Roden, E. E.; Brooks, S. C.; Chien, Y.; Murray, C. J.

2004-05-01

Uranium is a significant groundwater contaminant at many former mining and processing sites. In its oxidized state, U(VI) is soluble and mobile, although strongly retarded by sorption to natural iron oxide surfaces. It has been demonstrated that commonly occurring subsurface microorganisms can reduce uranium and other metals when provided sufficient carbon as an electron donor. Reduced U(IV) precipitates as a solid phase; therefore biostimulation provides a potential strategy for in situ removal from contaminated groundwater. However, these biogeochemical reactions occur in the context of a complex heterogeneous environment in which flow and transport dynamics and abiotic reactions can have significant impacts. We have constructed a high-resolution numerical model of groundwater flow and multicomponent reactive transport that incorporates heterogeneity in hydraulic conductivity and initial Fe(III) distribution, microbial growth and transport dynamics, and effects of sorption or precipitation of biogenic Fe(II) on availability of Fe(III) as an electron acceptor. The biogeochemical reaction models and their parameters are based on laboratory experiments; the heterogeneous field-scale property distributions are based on interpretations of geophysical and other observations at a highly characterized field site. The model is being run in Monte Carlo mode to examine the controls that these factors exert on 1) the initial distribution of sorbed uranium in an oxic environment and 2) the reduction and immobilization of uranium upon introduction of a soluble electron donor.

Actin homolog MreB affects chromosome segregation by regulating topoisomerase IV in Escherichia coli.

PubMed

Madabhushi, Ram; Marians, Kenneth J

2009-01-30

In Escherichia coli, topoisomerase IV, a type II topoisomerase, mediates the resolution of topological linkages between replicated daughter chromosomes and is essential for chromosome segregation. Topo IV activity is restricted to only a short interval late in the cell cycle. However, the mechanism that confers this temporal regulation is unknown. Here we report that the bacterial actin homolog MreB participates in the temporal oscillation of Topo IV activity. We show that mreB mutant strains are deficient in Topo IV activity. In addition, we demonstrate that, depending upon whether it is in a monomeric or polymerized state, MreB affects Topo IV activity differentially. In addition, MreB physically interacts with the ParC subunit of Topo IV. Together, these results may explain how dynamics of the bacterial cytoskeleton are coordinated with the timing of chromosome segregation.

Parametric study of natural circulation flow in molten salt fuel in molten salt reactor

NASA Astrophysics Data System (ADS)

Pauzi, Anas Muhamad; Cioncolini, Andrea; Iacovides, Hector

2015-04-01

The Molten Salt Reactor (MSR) is one of the most promising system proposed by Generation IV Forum (GIF) for future nuclear reactor systems. Advantages of the MSR are significantly larger compared to other reactor system, and is mainly achieved from its liquid nature of fuel and coolant. Further improvement to this system, which is a natural circulating molten fuel salt inside its tube in the reactor core is proposed, to achieve advantages of reducing and simplifying the MSR design proposed by GIF. Thermal hydraulic analysis on the proposed system was completed using a commercial computation fluid dynamics (CFD) software called FLUENT by ANSYS Inc. An understanding on theory behind this unique natural circulation flow inside the tube caused by fission heat generated in molten fuel salt and tube cooling was briefly introduced. Currently, no commercial CFD software could perfectly simulate natural circulation flow, hence, modeling this flow problem in FLUENT is introduced and analyzed to obtain best simulation results. Results obtained demonstrate the existence of periodical transient nature of flow problem, hence improvements in tube design is proposed based on the analysis on temperature and velocity profile. Results show that the proposed system could operate at up to 750MW core power, given that turbulence are enhanced throughout flow region, and precise molten fuel salt physical properties could be defined. At the request of the authors and the Proceedings Editor the name of the co-author Andrea Cioncolini was corrected from Andrea Coincolini. The same name correction was made in the Acknowledgement section on page 030004-10 and in reference number 4. The updated article was published on 11 May 2015.

Analysis and design of three dimensional supersonic nozzles. Volume 2: Numerical program for analysis of nozzle-exhaust flow fields

NASA Technical Reports Server (NTRS)

Kalben, P.

1972-01-01

The FORTRAN IV Program developed to analyze the flow field associated with scramjet exhaust systems is presented. The instructions for preparing input and interpreting output are described. The program analyzes steady three dimensional supersonic flow by the reference plane characteristic technique. The governing equations and numerical techniques employed are presented in Volume 1 of this report.

Estimating the effects of wages on obesity.

PubMed

Kim, DaeHwan; Leigh, John Paul

2010-05-01

To estimate the effects of wages on obesity and body mass. Data on household heads, aged 20 to 65 years, with full-time jobs, were drawn from the Panel Study of Income Dynamics for 2003 to 2007. The Panel Study of Income Dynamics is a nationally representative sample. Instrumental variables (IV) for wages were created using knowledge of computer software and state legal minimum wages. Least squares (linear regression) with corrected standard errors were used to estimate the equations. Statistical tests revealed both instruments were strong and tests for over-identifying restrictions were favorable. Wages were found to be predictive (P < 0.05) of obesity and body mass in regressions both before and after applying IVs. Coefficient estimates suggested stronger effects in the IV models. Results are consistent with the hypothesis that low wages increase obesity prevalence and body mass.

The blood flow in the periodontal ligament regulated by the sympathetic and sensory nerves in the cat.

PubMed

Karita, K; Izumi, H; Tabata, T; Kuriwada, S; Sasano, T; Sanjo, D

1989-01-01

This study was carried out to investigate the nervous control of the blood flow in the periodontal ligament measured by laser Doppler flowmeter. Ten adult cats were anesthetized with pentobarbital sodium (initial dose of 30 mg/kg, i.v. and maintenance dose of 5 mg/kg, i.v.). After enucleating the left eye ball, the superior alveolar nerve was exposed. The bone overlying the labial aspect of the left maxillary canine tooth root was pared away until a transparent layer of bone was left covering the periodontal ligament. A laser light from a probe of the flowmeter fixed at the tooth was beamed through the thinned bone. Three different patterns of responses were observed following the electrical stimulation of the distal end of the cut superior alveolar nerve: an increasing, a decreasing and a biphasic change of blood flow. The application of capsaicin onto the superior alveolar nerve reduced the response of blood flow increase but had no effect on the response of blood flow decrease. On the other hand, the response of blood flow decrease was completely inhibited by the pretreatment with phentolamine while the response of blood flow increase was not affected. The present results suggest that blood flow in the periodontal ligament of cats is controlled by sympathetic alpha-adrenergic fibers for vasoconstriction and by sensory fibers for vasodilation.

Water table dynamics and biogeochemical cycling in a shallow, variably-saturated floodplain

DOE PAGES

Yabusaki, Steven B.; Wilkins, Michael J.; Fang, Yilin; ...

2017-02-20

Three-dimensional variably saturated flow and multicomponent biogeochemical reactive transport modeling, based on published and newly generated data, is used to better understand the interplay of hydrology, geochemistry, and biology controlling the cycling of carbon, nitrogen, oxygen, iron, sulfur, and uranium in a shallow floodplain. In this system, aerobic respiration generally maintains anoxic groundwater below an oxic vadose zone until seasonal snowmelt-driven water table peaking transports dissolved oxygen (DO) and nitrate from the vadose zone into the alluvial aquifer. The response to this perturbation is localized due to distinct physico-biogeochemical environments and relatively long time scales for transport through the floodplainmore » aquifer and vadose zone. Naturally reduced zones (NRZs) containing sediments higher in organic matter, iron sulfides, and non-crystalline U(IV) rapidly consume DO and nitrate to maintain anoxic conditions, yielding Fe(II) from FeS oxidative dissolution, nitrite from denitrification, and U(VI) from nitrite-promoted U(IV) oxidation. Redox cycling is a key factor for sustaining the observed aquifer behaviors despite continuous oxygen influx and the annual hydrologically induced oxidation event. Furthermore, depth-dependent activity of fermenters, aerobes, nitrate reducers, sulfate reducers, and chemolithoautotrophs (e.g., oxidizing Fe(II), S compounds, and ammonium) is linked to the presence of DO, which has higher concentrations near the water table.« less

Understanding Angiography-Based Aneurysm Flow Fields through Comparison with Computational Fluid Dynamics.

PubMed

Cebral, J R; Mut, F; Chung, B J; Spelle, L; Moret, J; van Nijnatten, F; Ruijters, D

2017-06-01

Hemodynamics is thought to be an important factor for aneurysm progression and rupture. Our aim was to evaluate whether flow fields reconstructed from dynamic angiography data can be used to realistically represent the main flow structures in intracranial aneurysms. DSA-based flow reconstructions, obtained during interventional treatment, were compared qualitatively with flow fields obtained from patient-specific computational fluid dynamics models and quantitatively with projections of the computational fluid dynamics fields (by computing a directional similarity of the vector fields) in 15 cerebral aneurysms. The average similarity between the DSA and the projected computational fluid dynamics flow fields was 78% in the parent artery, while it was only 30% in the aneurysm region. Qualitatively, both the DSA and projected computational fluid dynamics flow fields captured the location of the inflow jet, the main vortex structure, the intrasaccular flow split, and the main rotation direction in approximately 60% of the cases. Several factors affect the reconstruction of 2D flow fields from dynamic angiography sequences. The most important factors are the 3-dimensionality of the intrasaccular flow patterns and inflow jets, the alignment of the main vortex structure with the line of sight, the overlapping of surrounding vessels, and possibly frame rate undersampling. Flow visualization with DSA from >1 projection is required for understanding of the 3D intrasaccular flow patterns. Although these DSA-based flow quantification techniques do not capture swirling or secondary flows in the parent artery, they still provide a good representation of the mean axial flow and the corresponding flow rate. © 2017 by American Journal of Neuroradiology.

Determination of dipyrone in pharmaceutical preparations based on the chemiluminescent reaction of the quinolinic hydrazide-H2O2-vanadium(IV) system and flow-injection analysis.

PubMed

Pradana Pérez, Juan A; Durand Alegría, Jesús S; Hernando, Pilar Fernández; Sierra, Adolfo Narros

2012-01-01

A rapid, economic and sensitive chemiluminescent method involving flow-injection analysis was developed for the determination of dipyrone in pharmaceutical preparations. The method is based on the chemiluminescent reaction between quinolinic hydrazide and hydrogen peroxide in a strongly alkaline medium, in which vanadium(IV) acts as a catalyst. Principal chemical and physical variables involved in the flow-injection system were optimized using a modified simplex method. The variations in the quantum yield observed when dipyrone was present in the reaction medium were used to determine the concentration of this compound. The proposed method requires no preconcentration steps and reliably quantifies dipyrone over the linear range 1-50 µg/mL. In addition, a sample throughput of 85 samples/h is possible. Copyright © 2011 John Wiley & Sons, Ltd.

Minnowbrook IV: 2003 Workshop on Transition and Unsteady Aspects of Turbomachinery Flows

NASA Technical Reports Server (NTRS)

LaGraff, John E. (Editor); Ashpis, David E. (Editor)

2004-01-01

On August 17 to 20, 2003, over 40 attendees participated in a workshop entitled "Minnowbrook IV.2003 Workshop on Transition and Unsteady Aspects of Turbomachinery Flows. Earlier themes focused on improving the understanding of late stage (final breakdown) of boundary layer transition. The specific engineering application of improving design codes for turbomachinery was encouraged by the attendance of representatives from gas turbine manufacturers. Written papers were not requested. Abstracts and copies of figures were the only written record of the workshop aside from specifically commissioned transcriptions of a workshop summary and the extensive working group reports, discussions, and summary that followed on the final morning of the workshop.

Tephra Blanket Record of a Violent Strombolian Eruption, Sunset Crater, Arizona

NASA Astrophysics Data System (ADS)

Wagner, K. D.; Ort, M. H.

2015-12-01

New fieldwork provides a detailed description of the widespread tephra of the ~1085 CE Sunset Crater eruption in the San Francisco Volcanic Field, Arizona, and refines interpretation of the eruptive sequence. The basal fine-lapilli tephra-fall-units I-IV are considered in detail. Units I and II are massive, with Unit I composed of angular to spiny clasts and II composed of more equant, oxidized clasts. Units III and IV have inversely graded bases and massive tops and are composed of angular to spiny iridescent and mixed iridescent and oxidized angular clasts, respectively. Xenoliths are rare in all units (<0.1%): sedimentary xenoliths are consistent with the known shallow country rock (Moenkopi and Kaibab Fms); magmatic xenoliths are pumiceous rhyolite mingled with basalt. Unit II is less sideromelane rich (20%) than Units I, III, and IV (60-80%). Above these units are at least two more coarse tephra-fall units. Variably preserved ash and fine-lapilli laminae cap the tephra blanket. This deposit is highly susceptible to reworking, and likely experienced both syn- and post-eruptive aeolian redistribution. It appears as either well sorted, alternating planar-parallel beds of ash and fine lapilli with rare wavy beds, or as cross- or planar-bedded ash. The tephra blanket as a whole is stratigraphically underlain by a fissure-fed lava flow and lapilli-fall units are intercalated with two larger flows. Mean grain size is coarsest in Unit I but coarsens in Units II-IV. Units I, III, and IV are moderately to poorly sorted with no skew. Unit II is better sorted and more coarse-skewed. Units I and III are slightly more platykurtic than II and IV. Without considering possible spatial effects introduced by dispersion patterns, bootstrap ANOVA confidence intervals suggest at least Unit II sorting and skewness are from distinct populations. Isopachs indicate Units I and II were associated with a 10-km-long fissure source. After or during Unit II's deposition, activity localized to Sunset Crater. Units III and IV were emplaced with waxing to sustained activity, and followed by at least two more sustained episodes. Two lava flows began effusing from the cone during this period and remained active after explosive activity ceased. Primary tephra deposition ended with a period of small discrete explosions.

Isolation-by-distance in landscapes: considerations for landscape genetics

PubMed Central

van Strien, M J; Holderegger, R; Van Heck, H J

2015-01-01

In landscape genetics, isolation-by-distance (IBD) is regarded as a baseline pattern that is obtained without additional effects of landscape elements on gene flow. However, the configuration of suitable habitat patches determines deme topology, which in turn should affect rates of gene flow. IBD patterns can be characterized either by monotonically increasing pairwise genetic differentiation (for example, FST) with increasing interdeme geographic distance (case-I pattern) or by monotonically increasing pairwise genetic differentiation up to a certain geographical distance beyond which no correlation is detectable anymore (case-IV pattern). We investigated if landscape configuration influenced the rate at which a case-IV pattern changed to a case-I pattern. We also determined at what interdeme distance the highest correlation was measured between genetic differentiation and geographic distance and whether this distance corresponded to the maximum migration distance. We set up a population genetic simulation study and assessed the development of IBD patterns for several habitat configurations and maximum migration distances. We show that the rate and likelihood of the transition of case-IV to case-I FST–distance relationships was strongly influenced by habitat configuration and maximum migration distance. We also found that the maximum correlation between genetic differentiation and geographic distance was not related to the maximum migration distance and was measured across all deme pairs in a case-I pattern and, for a case-IV pattern, at the distance where the FST–distance curve flattens out. We argue that in landscape genetics, separate analyses should be performed to either assess IBD or the landscape effects on gene flow. PMID:25052412

SPECIATION OF SELENIUM AND ARSENIC COMPOUNDS BY CAPILLARY ELECTROPHORESIS WITH HYDRODYNAMICALLY MODIFIED ELECTROOSMOTIC FLOW AND ON-LINE REDUCTION OF SELENIUM(VI) TO SELENIUM(IV) WITH HYDRIDE GENERATION INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRIC DETECTION

EPA Science Inventory

Capillary electrophoresis (CE) with hydride generation inductively coupled plasma mass spectrometry was used to determine four arsenicals and two selenium species. Selenate (SeVI) was reduced on-line to selenite (SeIV') by mixing the CE effluent with concentrated HCl. A microporo...

NetFlow Dynamics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Corbet Jr., Thomas F; Beyeler, Walter E; Vanwestrienen, Dirk

NetFlow Dynamics is a web-accessible analysis environment for simulating dynamic flows of materials on model networks. Performing a simulation requires both the NetFlow Dynamics application and a network model which is a description of the structure of the nodes and edges of a network including the flow capacity of each edge and the storage capacity of each node, and the sources and sinks of the material flowing on the network. NetFlow Dynamics consists of databases for storing network models, algorithms to calculate flows on networks, and a GIS-based graphical interface for performing simulations and viewing simulation results. Simulated flows aremore » dynamic in the sense that flows on each edge of the network and inventories at each node change with time and can be out of equilibrium with boundary conditions. Any number of network models could be simulated using Net Flow Dynamics. To date, the models simulated have been models of petroleum infrastructure. The main model has been the National Transportation Fuels Model (NTFM), a network of U.S. oil fields, transmission pipelines, rail lines, refineries, tank farms, and distribution terminals. NetFlow Dynamics supports two different flow algorithms, the Gradient Flow algorithm and the Inventory Control algorithm, that were developed specifically for the NetFlow Dynamics application. The intent is to add additional algorithms in the future as needed. The ability to select from multiple algorithms is desirable because a single algorithm never covers all analysis needs. The current algorithms use a demand-driven capacity-constrained formulation which means that the algorithms strive to use all available capacity and stored inventory to meet desired flows to sinks, subject to the capacity constraints of each network component. The current flow algorithms are best suited for problems in which a material flows on a capacity-constrained network representing a supply chain in which the material supplied can be stored at each node of the network. In the petroleum models, the flowing materials are crude oil and refined products that can be stored at tank farms, refineries, or terminals (i.e. the nodes of the network). Examples of other network models that could be simulated are currency flowing in a financial network, agricultural products moving to market, or natural gas flowing on a pipeline network.« less

Dynamics of comb-of-comb-network polymers in random layered flows

NASA Astrophysics Data System (ADS)

Katyal, Divya; Kant, Rama

2016-12-01

We analyze the dynamics of comb-of-comb-network polymers in the presence of external random flows. The dynamics of such structures is evaluated through relevant physical quantities, viz., average square displacement (ASD) and the velocity autocorrelation function (VACF). We focus on comparing the dynamics of the comb-of-comb network with the linear polymer. The present work displays an anomalous diffusive behavior of this flexible network in the random layered flows. The effect of the polymer topology on the dynamics is analyzed by varying the number of generations and branch lengths in these networks. In addition, we investigate the influence of external flow on the dynamics by varying flow parameters, like the flow exponent α and flow strength Wα. Our analysis highlights two anomalous power-law regimes, viz., subdiffusive (intermediate-time polymer stretching and flow-induced diffusion) and superdiffusive (long-time flow-induced diffusion). The anomalous long-time dynamics is governed by the temporal exponent ν of ASD, viz., ν =2 -α /2 . Compared to a linear polymer, the comb-of-comb network shows a shorter crossover time (from the subdiffusive to superdiffusive regime) but a reduced magnitude of ASD. Our theory displays an anomalous VACF in the random layered flows that scales as t-α /2. We show that the network with greater total mass moves faster.

Phase transitions of antibiotic clarithromycin forms I, IV and new form VII crystals.

PubMed

Ito, Masataka; Shiba, Rika; Watanabe, Miteki; Iwao, Yasunori; Itai, Shigeru; Noguchi, Shuji

2018-06-01

Metastable crystal form I of the antibiotic clarithromycin has a pharmaceutically valuable characteristic that its crystalline phase transition can be applied for its sustained release from tablets. The phase transition of form I was investigated in detail by single crystal and powder X-ray analyses, dynamic vapor sorption analysis and thermal analysis. The single crystal structure of form I revealed that form I was not an anhydrate crystal but contained a partially occupied water molecule in the channel-like void space. Dynamic vapor sorption (DVS) analysis demonstrated that form I crystals reversibly sorbed water molecules in two steps when the relative humidity (RH) increased and finally transited to hydrate form IV at 95% RH. DVS analysis also showed that when the RH decreased form IV crystals lost water molecules at 40% RH and transited to the newly identified anhydrate crystal form VII. Form VII reversibly transited to form IV at lower RH than form I, suggesting that form I is more suitable for manufacturing a sustained-release tablet of CAM utilizing the crystalline phase transition. Copyright © 2018 Elsevier B.V. All rights reserved.

Numerical Modeling of Three-Dimensional Confined Flows

NASA Technical Reports Server (NTRS)

Greywall, M. S.

1981-01-01

A three dimensional confined flow model is presented. The flow field is computed by calculating velocity and enthalpy along a set of streamlines. The finite difference equations are obtained by applying conservation principles to streamtubes constructed around the chosen streamlines. With appropriate substitutions for the body force terms, the approach computes three dimensional magnetohydrodynamic channel flows. A listing of a computer code, based on this approach is presented in FORTRAN IV language. The code computes three dimensional compressible viscous flow through a rectangular duct, with the duct cross section specified along the axis.

Pore-scale characterization of biogeochemical controls on iron and uranium speciation under flow conditions.

PubMed

Pearce, Carolyn I; Wilkins, Michael J; Zhang, Changyong; Heald, Steve M; Fredrickson, Jim K; Zachara, John M

2012-08-07

Etched silicon microfluidic pore network models (micromodels) with controlled chemical and redox gradients, mineralogy, and microbiology under continuous flow conditions are used for the incremental development of complex microenvironments that simulate subsurface conditions. We demonstrate the colonization of micromodel pore spaces by an anaerobic Fe(III)-reducing bacterial species (Geobacter sulfurreducens) and the enzymatic reduction of a bioavailable Fe(III) phase within this environment. Using both X-ray microprobe and X-ray absorption spectroscopy, we investigate the combined effects of the precipitated Fe(III) phases and the microbial population on uranium biogeochemistry under flow conditions. Precipitated Fe(III) phases within the micromodel were most effectively reduced in the presence of an electron shuttle (AQDS), and Fe(II) ions adsorbed onto the precipitated mineral surface without inducing any structural change. In the absence of Fe(III), U(VI) was effectively reduced by the microbial population to insoluble U(IV), which was precipitated in discrete regions associated with biomass. In the presence of Fe(III) phases, however, both U(IV) and U(VI) could be detected associated with biomass, suggesting reoxidation of U(IV) by localized Fe(III) phases. These results demonstrate the importance of the spatial localization of biomass and redox active metals, and illustrate the key effects of pore-scale processes on contaminant fate and reactive transport.

Point-of-care detection and real-time monitoring of intravenously delivered drugs via tubing with an integrated SERS sensor.

PubMed

Wu, Hsin-Yu; Cunningham, Brian T

2014-05-21

We demonstrate an approach for detection, identification, and kinetic monitoring of drugs flowing within tubing, through the use of a plasmonic nanodome array (PNA) surface. The PNA structures are fabricated using a low-cost nanoreplica molding process upon a flexible plastic substrate that is subsequently integrated with a flow cell that connects in series with ordinary intravenous (IV) drug delivery tubing. To investigate the potential clinical applications for point-of-care detection and real-time monitoring, we perform SERS detection of ten pharmaceutical compounds (hydrocodone, levorphanol, morphine, oxycodone, methadone, phenobarbital, dopamine, diltiazem, promethazine, and mitoxantrone). We demonstrate dose-dependent SERS signal magnitude, resulting in detection limits (ng ml(-1)) well below typical administered dosages (mg ml(-1)). Further, we show that the detected drugs are not permanently attached to the PNA surface, and thus our approach is capable of performing continuous monitoring of drug delivery as materials flow through IV tubing that is connected in series with the sensor. Finally, we demonstrate the potential co-detection of multiple drugs when they are mixed together, and show excellent reproducibility and stability of SERS measurements for periods extending at least five days. The capabilities reported here demonstrate the potential to use PNA SERS surfaces for enhancing the safety of IV drug delivery.

Liquid Metals as Plasma-facing Materials for Fusion Energy Systems: From Atoms to Tokamaks

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stone, Howard A.; Koel, Bruce E.; Bernasek, Steven L.

The objective of our studies was to advance our fundamental understanding of liquid metals as plasma-facing materials for fusion energy systems, with a broad scope: from atoms to tokamaks. The flow of liquid metals offers solutions to significant problems of the plasma-facing materials for fusion energy systems. Candidate metals include lithium, tin, gallium, and their eutectic combinations. However, such liquid metal solutions can only be designed efficiently if a range of scientific and engineering issues are resolved that require advances in fundamental fluid dynamics, materials science and surface science. In our research we investigated a range of significant and timelymore » problems relevant to current and proposed engineering designs for fusion reactors, including high-heat flux configurations that are being considered by leading fusion energy groups world-wide. Using experimental and theoretical tools spanning atomistic to continuum descriptions of liquid metals, and bridging surface chemistry, wetting/dewetting and flow, our research has advanced the science and engineering of fusion energy materials and systems. Specifically, we developed a combined experimental and theoretical program to investigate flows of liquid metals in fusion-relevant geometries, including equilibrium and stability of thin-film flows, e.g. wetting and dewetting, effects of electromagnetic and thermocapillary fields on liquid metal thin-film flows, and how chemical interactions and the properties of the surface are influenced by impurities and in turn affect the surface wetting characteristics, the surface tension, and its gradients. Because high-heat flux configurations produce evaporation and sputtering, which forces rearrangement of the liquid, and any dewetting exposes the substrate to damage from the plasma, our studies addressed such evaporatively driven liquid flows and measured and simulated properties of the different bulk phases and material interfaces. The range of our studies included (i) quantum mechanical calculations that allow inclusion of many thousands of atoms for the characterization of the interface of liquid metals exposed to continuous bombardment by deuterium and tritium as expected in fusion, (ii) molecular dynamics studies of the phase behavior of liquid metals, which (a) utilize thermodynamic properties computed using our quantum mechanical calculations and (b) establish material and wetting properties of the liquid metals, including relevant eutectics, (iii) experimental investigations of the surface science of liquid metals, interacting both with the solid substrate as well as gaseous species, and (iv) fluid dynamical studies that incorporate the material and surface science results of (ii) and (iii) in order to characterize flow in capillary porous materials and the thin-film flow along curved boundaries, both of which are potentially major components of plasma-facing materials. The outcome of these integrated studies was new understanding that enables developing design rules useful for future developments of the plasma-facing components critical to the success of fusion energy systems.« less

Computing Cooling Flows in Turbines

NASA Technical Reports Server (NTRS)

Gauntner, J.

1986-01-01

Algorithm developed for calculating both quantity of compressor bleed flow required to cool turbine and resulting decrease in efficiency due to cooling air injected into gas stream. Program intended for use with axial-flow, air-breathing, jet-propulsion engines with variety of airfoil-cooling configurations. Algorithm results compared extremely well with figures given by major engine manufacturers for given bulk-metal temperatures and cooling configurations. Program written in FORTRAN IV for batch execution.

A new experimental material for modeling relief dynamics and interactions between tectonics and surface processes

NASA Astrophysics Data System (ADS)

Graveleau, F.; Hurtrez, J.-E.; Dominguez, S.; Malavieille, J.

2011-12-01

We developed a new granular material (MatIV) to study experimentally landscape evolution in active mountain belt piedmonts. Its composition and related physical properties have been determined using empirical criteria derived from the scaling of deformation, erosion-transport and sedimentation natural processes. MatIV is a water-saturated composite material made up with 4 granular components (silica powder, glass microbeads, plastic powder and graphite) whose physical, mechanical and erosion-related properties were measured with different laboratory tests. Mechanical measurements were made on a modified Hubbert-type direct shear apparatus. Erosion-related properties were determined using an experimental set-up that allows quantifying the erosion/sedimentation budget from tilted relaxation topographies. For MatIV, we also investigated the evolution of mean erosion rates and stream power erosion law exponents in 1D as a function of slope. Our results indicate that MatIV satisfies most of the defined criteria. It deforms brittlely according to the linear Mohr-Coulomb failure criterion and localizes deformation along discrete faults. Its erosion pattern is characterized by realistic hillslope and channelized processes (slope diffusion, mass wasting, channel incision). During transport, eroded particles are sorted depending on their density and shape, which results in stratified alluvial deposits displaying lateral facies variations. To evaluate the degree of similitude between model and nature, we used a new experimental device that combines accretionary wedge deformation mechanisms and surface runoff erosion processes. Results indicate that MatIV succeeded in producing detailed morphological and sedimentological features (drainage basin, channel network, terrace, syntectonic alluvial fan). Geometric, kinematic and dynamic similarity criteria have been investigated to compare precisely model to nature. Although scaling is incomplete, it yields particularly informative orders of magnitude. With all these characteristics, MatIV appears as a very promising material to investigate experimentally a wide range of scientific questions dealing with relief dynamics and interactions between tectonics, erosion and sedimentation processes.

Navigation of a Satellite Cluster with Realistic Dynamics

DTIC Science & Technology

1991-12-01

20 2.2.1 Dynamics ( Clohessy - Wiltshire Equations) ............ 21 2.2.2 Iterated, Extended Kalman Filter.................26 iv I1l...8 Figure 4. Point mass and Clohessy - Wiltshire orbits (10 orbits) .......... 16 Figure 5. Real dynamics and Clohessy - Wiltshire orbits (10...filter ..... 31 Figure 8. Comparison of the Clohessy - Wiltshire and truth model solutions

Flow cells for bioanalytical and bioprocess applications with optimized dynamic response and flow characteristics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lancaster, V.R.; Modlin, D.N.

1994-12-31

In this study, the authors present a method for design and characterization of flow cells developed for minimum flow volume and optimal dynamic response with a given central observation area. The dynamic response of a circular shaped dual ported flow cell was compared to that obtained from a flow cell whose optimized shape was determined using this method. In the optimized flow cell design, the flow rate at the nominal operating pressure increased by 50% whereas the flow cell volume was reduced by 70%. In addition, the dynamic response of the new flow cell was found to be 200% fastermore » than the circular flow cell. The fluid dynamic analysis included simple graphical techniques utilizing free stream vorticity functions and Hagen-Poiseuille relationships. The flow cell dynamic response was measured using a fluorescence detection system. The fluoresce in emission from a 400{micro}m spot located at the exit port was measured as a function of time after switching the input to the flow cell between fluorescent and non-fluorescent solutions. Analysis of results revealed the system could be reasonably characterized as a first order dynamic system. Although some evidence of second order behavior was also observed, it is reasonable to assume that a first order model will provide adequate predictive capability for many real world applications. Given a set of flow cell requirements, the methods presented in this study can be used to design and characterize flow cells with lower reagent consumption and reduced purging times. These improvements can be readily translated into reduced process times and/or lower usage of high cost reagents.« less

A new Doppler-echo method to quantify regurgitant volume.

PubMed

Wang, S S; Rubenstein, J J; Goldman, M; Sidd, J J

1992-01-01

An in vitro technique using color flow imaging and continuous wave Doppler was developed to measure the initial regurgitant flow jet diameter and velocity integral to yield the parameters for a volume calculation. Jets were produced by volume-controlled injection through tubes of various diameters (1.3, 1.9, 2.8, and 3.5 mm) to deliver volumes from 1 to 7 ml over 100 to 300 msec at pressures from 40 to 200 mm Hg. One hundred forty-five samples were obtained. Flow jet diameter consistently overestimated tube diameter by 2 mm when injected volume was 1.5 to 7 ml and by 1.5 mm when injected volume was less than 1.5 ml. This offset was stable with various transducers (2.5, 3.5, 5.0 MHz) at normal gain setting (just under noise). Therefore, corrected flow jet diameter (FJD) = FJD - 2 mm, and Doppler volume = corrected flow jet area x velocity integral. A range of injectates from 1.1 to 7 ml generated Doppler volume of 1.0 to 8.2 ml. The relation between Doppler volume (DV) and injected volume (IV) was DV = 1.079 IV - 0.22, r2 = 0.945, p less than 0.01. This relation was not altered by tube diameter. Thus a method combining color flow imaging and continuous wave Doppler provides a reliable and accurate measure of in vitro flow volume.

Parameterizing Coefficients of a POD-Based Dynamical System

NASA Technical Reports Server (NTRS)

Kalb, Virginia L.

2010-01-01

A method of parameterizing the coefficients of a dynamical system based of a proper orthogonal decomposition (POD) representing the flow dynamics of a viscous fluid has been introduced. (A brief description of POD is presented in the immediately preceding article.) The present parameterization method is intended to enable construction of the dynamical system to accurately represent the temporal evolution of the flow dynamics over a range of Reynolds numbers. The need for this or a similar method arises as follows: A procedure that includes direct numerical simulation followed by POD, followed by Galerkin projection to a dynamical system has been proven to enable representation of flow dynamics by a low-dimensional model at the Reynolds number of the simulation. However, a more difficult task is to obtain models that are valid over a range of Reynolds numbers. Extrapolation of low-dimensional models by use of straightforward Reynolds-number-based parameter continuation has proven to be inadequate for successful prediction of flows. A key part of the problem of constructing a dynamical system to accurately represent the temporal evolution of the flow dynamics over a range of Reynolds numbers is the problem of understanding and providing for the variation of the coefficients of the dynamical system with the Reynolds number. Prior methods do not enable capture of temporal dynamics over ranges of Reynolds numbers in low-dimensional models, and are not even satisfactory when large numbers of modes are used. The basic idea of the present method is to solve the problem through a suitable parameterization of the coefficients of the dynamical system. The parameterization computations involve utilization of the transfer of kinetic energy between modes as a function of Reynolds number. The thus-parameterized dynamical system accurately predicts the flow dynamics and is applicable to a range of flow problems in the dynamical regime around the Hopf bifurcation. Parameter-continuation software can be used on the parameterized dynamical system to derive a bifurcation diagram that accurately predicts the temporal flow behavior.

78 FR 51242 - Self-Regulatory Organizations; Topaz Exchange, LLC; Notice of Filing and Immediate Effectiveness...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-20

..., firms internalizing customer orders are also able to generate payment for order flow (``PFOF'') fees of... provide incentives for market participants to submit customer order flow to the Exchange and thus, creates... to the following class of market participants: (i) Customer, (ii) Professional, (iii) Firm, (iv) Non...

Measurements of C V flows from thermal charge-exchange excitation in divertor plasmas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zaniol, B.; Isler, R. C.; Brooks, N. H.

2001-10-01

Certain transitions of C IV (C{sup 3+}) from n=7 to n=6 ({approx}7226 {angstrom}) and from n=6 to n=5 ({approx}4660 {angstrom}) sometimes appear much brighter in tokamak divertors than expected for electron-impact excitation from the ground state. This situation occurs because of charge exchange between C V (C{sup 4+}) and recycling thermal deuterium atoms in the n=2 level. As a result, it is possible to extend parallel flow measurements of carbon, which have previously been performed on C II--C IV ions using Doppler shift spectroscopy, to include flows of the He-like C V ions. The work described here includes modeling ofmore » the spectral features, correlation of state populations with classical Monte Carlo trajectory (CTMC) predictions, and applications to flow measurements in the DIII-D divertor [Plasma Physics Controlled Nuclear Fusion Research 1986 (International Atomic Energy Agency, Vienna, 1987), Vol. I, p. 159; Proceedings of the 18th IEEE/NPSS Symposium on Fusion Engineering, Albuquerque (Institute of Electrical and Electronic Engineers, Piscataway, 1999), p. 515].« less

Measurements of C V flows from thermal charge-exchange excitation in divertor plasmas

NASA Astrophysics Data System (ADS)

Zaniol, B.; Isler, R. C.; Brooks, N. H.; West, W. P.; Olson, R. E.

2001-10-01

Certain transitions of C IV (C3+) from n=7 to n=6 (≈7226 Å) and from n=6 to n=5 (≈4660 Å) sometimes appear much brighter in tokamak divertors than expected for electron-impact excitation from the ground state. This situation occurs because of charge exchange between C V (C4+) and recycling thermal deuterium atoms in the n=2 level. As a result, it is possible to extend parallel flow measurements of carbon, which have previously been performed on C II-C IV ions using Doppler shift spectroscopy, to include flows of the He-like C V ions. The work described here includes modeling of the spectral features, correlation of state populations with classical Monte Carlo trajectory (CTMC) predictions, and applications to flow measurements in the DIII-D divertor [Plasma Physics Controlled Nuclear Fusion Research 1986 (International Atomic Energy Agency, Vienna, 1987), Vol. I, p. 159; Proceedings of the 18th IEEE/NPSS Symposium on Fusion Engineering, Albuquerque (Institute of Electrical and Electronic Engineers, Piscataway, 1999), p. 515].

Assessment of rock wool as support material for on-site sanitation: hydrodynamic and mechanical characterization.

PubMed

Wanko, Adrien; Laurent, Julien; Bois, Paul; Mosé, Robert; Wagner-Kocher, Christiane; Bahlouli, Nadia; Tiffay, Serge; Braun, Bouke; Provo kluit, Pieter-Willem

2016-01-01

This study proposes mechanical and hydrodynamic characterization of rock wool used as support material in compact filter. A double-pronged approach, based on experimental simulation of various physical states of this material was done. First of all a scanning electron microscopy observation allows to highlight the fibrous network structure, the fibres sizing distribution and the atomic absorption spectrum. The material was essentially lacunar with 97 ± 2% of void space. Static compression tests on variably saturated rock wool samples provide the fact that the strain/stress behaviours depend on both the sample conditioning and the saturation level. Results showed that water exerts plastifying effect on mechanical behaviour of rock wool. The load-displacement curves and drainage evolution under different water saturation levels allowed exhibiting hydraulic retention capacities under stress. Finally, several tracer experiments on rock wool column considering continuous and batch feeding flow regime allowed: (i) to determine the flow model for each test case and the implications for water dynamic in rock wool medium, (ii) to assess the rock wool double porosity and discuss its advantages for wastewater treatment, (iii) to analyse the benefits effect for water treatment when the high level of rock wool hydric retention was associated with the plug-flow effect, and (iv) to discuss the practical contributions for compact filter conception and management.

Unsteady aerodynamics of reverse flow dynamic stall on an oscillating blade section

NASA Astrophysics Data System (ADS)

Lind, Andrew H.; Jones, Anya R.

2016-07-01

Wind tunnel experiments were performed on a sinusoidally oscillating NACA 0012 blade section in reverse flow. Time-resolved particle image velocimetry and unsteady surface pressure measurements were used to characterize the evolution of reverse flow dynamic stall and its sensitivity to pitch and flow parameters. The effects of a sharp aerodynamic leading edge on the fundamental flow physics of reverse flow dynamic stall are explored in depth. Reynolds number was varied up to Re = 5 × 105, reduced frequency was varied up to k = 0.511, mean pitch angle was varied up to 15∘, and two pitch amplitudes of 5∘ and 10∘ were studied. It was found that reverse flow dynamic stall of the NACA 0012 airfoil is weakly sensitive to the Reynolds numbers tested due to flow separation at the sharp aerodynamic leading edge. Reduced frequency strongly affects the onset and persistence of dynamic stall vortices. The type of dynamic stall observed (i.e., number of vortex structures) increases with a decrease in reduced frequency and increase in maximum pitch angle. The characterization and parameter sensitivity of reverse flow dynamic stall given in the present work will enable the development of a physics-based analytical model of this unsteady aerodynamic phenomenon.

Experimental and analytical dynamic flow characteristics of an axial-flow fan from an air cushion landing system model

NASA Technical Reports Server (NTRS)

Thompson, W. C.; Boghani, A. B.; Leland, T. J. W.

1977-01-01

An investigation was conducted to compare the steady-state and dynamic flow characteristics of an axial-flow fan which had been used previously as the air supply fan for some model air cushion landing system studies. Steady-state flow characteristics were determined in the standard manner by using differential orifice pressures for the flow regime from free flow to zero flow. In this same regime, a correlative technique was established so that fan inlet and outlet pressures could be used to measure dynamic flow as created by a rotating damper. Dynamic tests at damper frequencies up to 5 Hz showed very different flow characteristics when compared with steady-state flow, particularly with respect to peak pressures and the pressure-flow relationship at fan stall and unstall. A generalized, rational mathematical fan model was developed based on physical fan parameters and a steady-state flow characteristic. The model showed good correlation with experimental tests at damper frequencies up to 5 Hz.

Mass loss in the interacting semi-detached binary delta librae

NASA Technical Reports Server (NTRS)

Mccluskey, George E., Jr.; Mccluskey, Carolina P. S.; Kondo, Yoji

1995-01-01

The interacting Algol-type binary Delta Librae (AOV + G: V) has been observed with the International Ultraviolet Explorer (IUE) satellite. More than fifty high resolution spectra in the far-ultraviolet and mid-ultraviolet spectrum have been analyzed in order to model the mass flow in the Delta Librae system. The resonance lines of Si IV and C IV are present in absorption and vary in strength both secularly and with phase. The radial velocities of the Si IV and C IV absorption lines generally follow the orbital motion of the primary star but deviate by typically a few tens of kilometers per second in the direction of the observer. The presence of Si IV and C IV features indicates the existence of a region considerably hotter than the normal AOV photosphere and, since these lines are present at all phases, this region must be fairly extensive. These results are interpreted in terms of a 'pseudo-photosphere' around the equatorial region of the AOV star, created by matter being accreted from the G-type companion. The widths of the Si IV and C IV absorption features imply that some of the matter lost by the G-star leaves the system entirely.

TRUMP; transient and steady state temperature distribution. [IBM360,370; CDC7600; FORTRAN IV (95%) and BAL (5%) (IBM); FORTRAN IV (CDC)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Elrod, D.C.; Turner, W.D.

TRUMP solves a general nonlinear parabolic partial differential equation describing flow in various kinds of potential fields, such as fields of temperature, pressure, or electricity and magnetism; simultaneously, it will solve two additional equations representing, in thermal problems, heat production by decomposition of two reactants having rate constants with a general Arrhenius temperature dependence. Steady-state and transient flow in one, two, or three dimensions are considered in geometrical configurations having simple or complex shapes and structures. Problem parameters may vary with spatial position, time, or primary dependent variables--temperature, pressure, or field strength. Initial conditions may vary with spatial position, andmore » among the criteria that may be specified for ending a problem are upper and lower limits on the size of the primary dependent variable, upper limits on the problem time or on the number of time-steps or on the computer time, and attainment of steady state.IBM360,370;CDC7600; FORTRAN IV (95%) and BAL (5%) (IBM); FORTRAN IV (CDC); OS/360 (IBM360), OS/370 (IBM370), SCOPE 2.1.5 (CDC7600); As dimensioned, the program requires 400K bytes of storage on an IBM370 and 145,100 (octal) words on a CDC7600.« less

Pharmacokinetic interaction between liquiritigenin (LQ) and DDB: increased glucuronidation of LQ in the liver possibly due to increased hepatic blood flow rate by DDB.

PubMed

Kang, Hee E; Chung, Hye J; Kim, Hyung S; Lee, Jee W; Lee, Myung G

2010-01-31

It has been reported that both liquiritigenin (LQ) and dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphenyl-2,2'-dicarboxylate (DDB) have a hepatoprotective effect, and administration of both drugs together shows additive protective effect against acute liver injuries. Therefore, the pharmacokinetic interaction between LQ and DDB in rats was studied. LQ (20 and 50mg/kg for the i.v. and p.o. administration, respectively), DDB (10mg/kg for both i.v. and p.o. administration), and both drugs together were once administered intravenously or orally to rats. After the i.v. administration of both drugs together, the Cl(nr) and AUC of LQ were significantly faster (by 30.5%) and smaller (by 22.5%), respectively, than those of without DDB due to the faster hepatic blood flow rate by DDB. After the p.o. administration of both drugs together, the AUC of LQ was comparable to that of without DDB due to negligible effect of DDB on intestinal metabolism of LQ. The pharmacokinetic parameters of DDB after both i.v. and p.o. administration were not altered by LQ, indicating that LQ did not considerably affect the pharmacokinetics of DDB in rats. Copyright 2009 Elsevier B.V. All rights reserved.

Mechanisms of inhibitory action of TRK-130 (Naltalimide), a μ-opioid receptor partial agonist, on the micturition reflex.

PubMed

Fujimura, Morihiro; Izumimoto, Naoki; Kanie, Sayoko; Kobayashi, Ryosuke; Yoshikawa, Satoru; Momen, Shinobu; Hirakata, Mikito; Komagata, Toshikazu; Okanishi, Satoshi; Iwata, Masashi; Hashimoto, Tadatoshi; Doi, Takayuki; Yoshimura, Naoki; Kawai, Koji

2017-04-01

To clarify the mechanism of inhibitory action of TRK-130 (Naltalimide), a unique µ-opioid receptor partial agonist, on the micturition reflex. The effect of TRK-130 on isovolumetric rhythmic bladder contractions (RBCs) was examined in guinea pigs, the effect of which was clarified by co-treatment with naloxone or in spinal cord transection. The effect of TRK-130 on urodynamic parameters was also observed in guinea pigs. In addition, the effect of TRK-130 on bladder contraction induced by peripheral stimulation of the pelvic nerve was investigated in rats. TRK-130 (0.001-0.01 mg/kg, iv) dose-dependently inhibited RBCs, which was dose-dependently antagonized by naloxone; however, the antagonism susceptibility was different from morphine (1 mg/kg, iv). The minimum effective dose (0.003 mg/kg) of TRK-130 remained similar in spinal cord-transected animals. TRK-130 (0.0025 mg/kg, iv) increased bladder capacity without changing the voiding efficiency, maximum flow rate, and intravesical pressure at the maximum flow rate, whereas oxybutynin (1 mg/kg, iv) increased the bladder capacity but affected the other parameters. TRK-130 (0.005 mg/kg, iv) did not produce significant changes on the bladder contractions induced by peripheral stimulation of the pelvic nerve, while oxybutynin (1 mg/kg, iv) significantly suppressed the bladder contractions. These results suggest that TRK-130 enhances the bladder storage function by modulating the afferent limb of the micturition reflex through µ-opioid receptors in the spinal cord. TRK-130 could be a more effective and safer therapeutic agent with a different fashion from antimuscarinics and conventional opioids for overactive bladder.

Making Optic Flow Robust to Dynamic Lighting Conditions for Real-Time Operation

DTIC Science & Technology

2016-03-17

ARL-TR-7629 ● MAR 2016 US Army Research Laboratory Making Optic Flow Robust to Dynamic Lighting Conditions for Real-Time...ARL-TR-7629 ● MAR 2016 US Army Research Laboratory Making Optic Flow Robust to Dynamic Lighting Conditions for Real-Time Operation...SUBTITLE Making Optic Flow Robust to Dynamic Lighting Conditions for Real-Time Operation 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT

Efficient quantum-classical method for computing thermal rate constant of recombination: application to ozone formation.

PubMed

Ivanov, Mikhail V; Babikov, Dmitri

2012-05-14

Efficient method is proposed for computing thermal rate constant of recombination reaction that proceeds according to the energy transfer mechanism, when an energized molecule is formed from reactants first, and is stabilized later by collision with quencher. The mixed quantum-classical theory for the collisional energy transfer and the ro-vibrational energy flow [M. Ivanov and D. Babikov, J. Chem. Phys. 134, 144107 (2011)] is employed to treat the dynamics of molecule + quencher collision. Efficiency is achieved by sampling simultaneously (i) the thermal collision energy, (ii) the impact parameter, and (iii) the incident direction of quencher, as well as (iv) the rotational state of energized molecule. This approach is applied to calculate third-order rate constant of the recombination reaction that forms the (16)O(18)O(16)O isotopomer of ozone. Comparison of the predicted rate vs. experimental result is presented.

Hot Gas Lines in T Tauri Stars

NASA Astrophysics Data System (ADS)

Ardila, David R.; Herczeg, Gregory J.; Gregory, Scott G.; Ingleby, Laura; France, Kevin; Brown, Alexander; Edwards, Suzan; Johns-Krull, Christopher; Linsky, Jeffrey L.; Yang, Hao; Valenti, Jeff A.; Abgrall, Hervé; Alexander, Richard D.; Bergin, Edwin; Bethell, Thomas; Brown, Joanna M.; Calvet, Nuria; Espaillat, Catherine; Hillenbrand, Lynne A.; Hussain, Gaitee; Roueff, Evelyne; Schindhelm, Eric R.; Walter, Frederick M.

2013-07-01

For Classical T Tauri Stars (CTTSs), the resonance doublets of N V, Si IV, and C IV, as well as the He II 1640 Å line, trace hot gas flows and act as diagnostics of the accretion process. In this paper we assemble a large high-resolution, high-sensitivity data set of these lines in CTTSs and Weak T Tauri Stars (WTTSs). The sample comprises 35 stars: 1 Herbig Ae star, 28 CTTSs, and 6 WTTSs. We find that the C IV, Si IV, and N V lines in CTTSs all have similar shapes. We decompose the C IV and He II lines into broad and narrow Gaussian components (BC and NC). The most common (50%) C IV line morphology in CTTSs is that of a low-velocity NC together with a redshifted BC. For CTTSs, a strong BC is the result of the accretion process. The contribution fraction of the NC to the C IV line flux in CTTSs increases with accretion rate, from ~20% to up to ~80%. The velocity centroids of the BCs and NCs are such that V BC >~ 4 V NC, consistent with the predictions of the accretion shock model, in at most 12 out of 22 CTTSs. We do not find evidence of the post-shock becoming buried in the stellar photosphere due to the pressure of the accretion flow. The He II CTTSs lines are generally symmetric and narrow, with FWHM and redshifts comparable to those of WTTSs. They are less redshifted than the CTTSs C IV lines, by ~10 km s-1. The amount of flux in the BC of the He II line is small compared to that of the C IV line, and we show that this is consistent with models of the pre-shock column emission. Overall, the observations are consistent with the presence of multiple accretion columns with different densities or with accretion models that predict a slow-moving, low-density region in the periphery of the accretion column. For HN Tau A and RW Aur A, most of the C IV line is blueshifted suggesting that the C IV emission is produced by shocks within outflow jets. In our sample, the Herbig Ae star DX Cha is the only object for which we find a P-Cygni profile in the C IV line, which argues for the presence of a hot (105 K) wind. For the overall sample, the Si IV and N V line luminosities are correlated with the C IV line luminosities, although the relationship between Si IV and C IV shows large scatter about a linear relationship and suggests that TW Hya, V4046 Sgr, AA Tau, DF Tau, GM Aur, and V1190 Sco are silicon-poor, while CV Cha, DX Cha, RU Lup, and RW Aur may be silicon-rich.

Nonlinear dynamics in flow through unsaturated fractured-porous media: Status and perspectives

DOE Office of Scientific and Technical Information (OSTI.GOV)

Faybishenko, Boris

2002-11-27

The need has long been recognized to improve predictions of flow and transport in partially saturated heterogeneous soils and fractured rock of the vadose zone for many practical applications, such as remediation of contaminated sites, nuclear waste disposal in geological formations, and climate predictions. Until recently, flow and transport processes in heterogeneous subsurface media with oscillating irregularities were assumed to be random and were not analyzed using methods of nonlinear dynamics. The goals of this paper are to review the theoretical concepts, present the results, and provide perspectives on investigations of flow and transport in unsaturated heterogeneous soils and fracturedmore » rock, using the methods of nonlinear dynamics and deterministic chaos. The results of laboratory and field investigations indicate that the nonlinear dynamics of flow and transport processes in unsaturated soils and fractured rocks arise from the dynamic feedback and competition between various nonlinear physical processes along with complex geometry of flow paths. Although direct measurements of variables characterizing the individual flow processes are not technically feasible, their cumulative effect can be characterized by analyzing time series data using the models and methods of nonlinear dynamics and chaos. Identifying flow through soil or rock as a nonlinear dynamical system is important for developing appropriate short- and long-time predictive models, evaluating prediction uncertainty, assessing the spatial distribution of flow characteristics from time series data, and improving chemical transport simulations. Inferring the nature of flow processes through the methods of nonlinear dynamics could become widely used in different areas of the earth sciences.« less

Surface-groundwater interactions in hard rocks in Sardon Catchment of western Spain: An integrated modeling approach

NASA Astrophysics Data System (ADS)

Hassan, S. M. Tanvir; Lubczynski, Maciek W.; Niswonger, Richard G.; Su, Zhongbo

2014-09-01

The structural and hydrological complexity of hard rock systems (HRSs) affects dynamics of surface-groundwater interactions. These complexities are not well described or understood by hydrogeologists because simplified analyses typically are used to study HRSs. A transient, integrated hydrologic model (IHM) GSFLOW (Groundwater and Surface water FLOW) was calibrated and post-audited using 18 years of daily groundwater head and stream discharge data to evaluate the surface-groundwater interactions in semi-arid, ∼80 km2 granitic Sardon hilly catchment in Spain characterized by shallow water table conditions, relatively low storage, dense drainage networks and frequent, high intensity rainfall. The following hydrological observations for the Sardon Catchment, and more generally for HRSs were made: (i) significant bi-directional vertical flows occur between surface water and groundwater throughout the HRSs; (ii) relatively large groundwater recharge represents 16% of precipitation (P, 562 mm.y-1) and large groundwater exfiltration (∼11% of P) results in short groundwater flow paths due to a dense network of streams, low permeability and hilly topographic relief; deep, long groundwater flow paths constitute a smaller component of the water budget (∼1% of P); quite high groundwater evapotranspiration (∼5% of P and ∼7% of total evapotranspiration); low permeability and shallow soils are the main reasons for relatively large components of Hortonian flow and interflow (15% and 11% of P, respectively); (iii) the majority of drainage from the catchment leaves as surface water; (iv) declining 18 years trend (4.44 mm.y-1) of groundwater storage; and (v) large spatio-temporal variability of water fluxes. This IHM study of HRSs provides greater understanding of these relatively unknown hydrologic systems that are widespread throughout the world and are important for water resources in many regions.

Surface-groundwater interactions in hard rocks in Sardon Catchment of western Spain: an integrated modeling approach

USGS Publications Warehouse

Hassan, S.M. Tanvir; Lubczynski, Maciek W.; Niswonger, Richard G.; Zhongbo, Su

2014-01-01

The structural and hydrological complexity of hard rock systems (HRSs) affects dynamics of surface–groundwater interactions. These complexities are not well described or understood by hydrogeologists because simplified analyses typically are used to study HRSs. A transient, integrated hydrologic model (IHM) GSFLOW (Groundwater and Surface water FLOW) was calibrated and post-audited using 18 years of daily groundwater head and stream discharge data to evaluate the surface–groundwater interactions in semi-arid, ∼80 km2 granitic Sardon hilly catchment in Spain characterized by shallow water table conditions, relatively low storage, dense drainage networks and frequent, high intensity rainfall. The following hydrological observations for the Sardon Catchment, and more generally for HRSs were made: (i) significant bi-directional vertical flows occur between surface water and groundwater throughout the HRSs; (ii) relatively large groundwater recharge represents 16% of precipitation (P, 562 mm.y−1) and large groundwater exfiltration (∼11% of P) results in short groundwater flow paths due to a dense network of streams, low permeability and hilly topographic relief; deep, long groundwater flow paths constitute a smaller component of the water budget (∼1% of P); quite high groundwater evapotranspiration (∼5% of P and ∼7% of total evapotranspiration); low permeability and shallow soils are the main reasons for relatively large components of Hortonian flow and interflow (15% and 11% of P, respectively); (iii) the majority of drainage from the catchment leaves as surface water; (iv) declining 18 years trend (4.44 mm.y−1) of groundwater storage; and (v) large spatio-temporal variability of water fluxes. This IHM study of HRSs provides greater understanding of these relatively unknown hydrologic systems that are widespread throughout the world and are important for water resources in many regions.

Galactic cannibalism. IV. The evidence-correlations between dynamical time scales and Bautz-Morgan type

DOE Office of Scientific and Technical Information (OSTI.GOV)

McGlynn, T.A.; Ostriker, J.P.

1980-11-01

If the luminosity of supergiant cD galaxies in particular, and the Bautz-Morgan sequence of galaxy types in general, is produced by dynamical evolutionary processes, then one expects to find a correlation between dynamical times and ..delta..M/sub 12/, the magnitude difference between first and second brightest cluster members.

Autogenic dynamics of debris-flow fans

NASA Astrophysics Data System (ADS)

van den Berg, Wilco; de Haas, Tjalling; Braat, Lisanne; Kleinhans, Maarten

2015-04-01

Alluvial fans develop their semi-conical shape by cyclic avulsion of their geomorphologically active sector from a fixed fan apex. These cyclic avulsions have been attributed to both allogenic and autogenic forcings and processes. Autogenic dynamics have been extensively studied on fluvial fans through physical scale experiments, and are governed by cyclic alternations of aggradation by unconfined sheet flow, fanhead incision leading to channelized flow, channel backfilling and avulsion. On debris-flow fans, however, autogenic dynamics have not yet been directly observed. We experimentally created debris-flow fans under constant extrinsic forcings, and show that autogenic dynamics are a fundamental intrinsic process on debris-flow fans. We found that autogenic cycles on debris-flow fans are driven by sequences of backfilling, avulsion and channelization, similar to the cycles on fluvial fans. However, the processes that govern these sequences are unique for debris-flow fans, and differ fundamentally from the processes that govern autogenic dynamics on fluvial fans. We experimentally observed that backfilling commenced after the debris flows reached their maximum possible extent. The next debris flows then progressively became shorter, driven by feedbacks on fan morphology and flow-dynamics. The progressively decreasing debris-flow length caused in-channel sedimentation, which led to increasing channel overflow and wider debris flows. This reduced the impulse of the liquefied flow body to the flow front, which then further reduced flow velocity and runout length, and induced further in-channel sedimentation. This commenced a positive feedback wherein debris flows became increasingly short and wide, until the channel was completely filled and the apex cross-profile was plano-convex. At this point, there was no preferential transport direction by channelization, and the debris flows progressively avulsed towards the steepest, preferential, flow path. Simultaneously, the debris flows started to channelize, forced by increasingly effective concentration of the flow impulse to the flow front, which caused more effective lateral levee formation and an increasingly well-defined channel. This process continued until the debris flows reached their maximum possible extent and the cycle was reverted. Channelization occurred in the absence of erosion, in contrast with fluvial fans. Backfilling and channelization cycles were gradual and symmetric, requiring multiple debris flows to be completed. These results add debris-flow fans to the spectrum of fan-shaped aqueous systems that are affected by autogenic dynamics, now ranging from low-gradient rivers systems to steep-gradient mass-flow fans.

Volcano-sedimentary characteristics in the Abu Treifiya Basin, Cairo-Suez District, Egypt: Example of dynamics and fluidization over sedimentary and volcaniclastic beds by emplacement of syn-volcanic basaltic rocks

NASA Astrophysics Data System (ADS)

Khalaf, E. A.; Abdel Motelib, A.; Hammed, M. S.; El Manawi, A. H.

2015-12-01

This paper describes the Neogene lava-sediment mingling from the Abu Treifiya Basin, Cairo-Suez district, Egypt. The lava-sediment interactions as peperites have been identified for the first time at the study area and can be used as paleoenvironmental indicators. The identification of peperite reflects contemporaneous time relationship between volcanism and sedimentation and this finding is of primary importance to address the evolutional reconstruction of the Abu Treifiya Basin. Characterization of the facies architecture and textural framework of peperites was carried out through detailed description and interpretation of their outcrops. The peperites and sedimentary rocks are up to 350 m thick and form a distinct stratigraphic framework of diverse lithology that is widespread over several kilometers at the study area. Lateral and vertical facies of the peperites vary from sediment intercalated with the extrusive/intrusive basaltic rocks forming peperitic breccias to lava-sediment contacts at a large to small scales, respectively. Peperites encompass five main facies types ascribed to: (i) carbonate sediments-hosted fluidal and blocky peperites, (ii) lava flow-hosted blocky peperites, (iii) volcaniclastics-hosted fluidal and blocky peperites, (iv) sandstone/siltstone rocks-hosted blocky peperites, and (iv) debris-flows-hosted blocky peperites. Soft sediment deformation structures, vesiculated sediments, sediments filled-vesicles, and fractures in lava flows indicate that lava flows mingled with unconsolidated wet sediments. All the peperites in this study could be described as blocky or fluidal, but mixtures of different clast shapes occur regardless of the host sediment. The presence of fluidal and blocky juvenile clasts elucidates different eruptive styles, reflecting a ductile and brittle fragmentation. The gradual variation from fluidal to blocky peperite texture, producing the vertical grading is affected by influencing factors, e.g., the viscosity, magma temperature, confining pressure, sediment fluidization, and vapor film at the magma-sediment interactions. Peperites in the study area record deposition within a shallow marine and fluvio-lacustrine environment accumulated in a rift-related basin developed during pre- to syn-rift phase, respectively. The facies transitions (peperites) in this area resulted from the explosive and sediment depositional processes, which were mingled separately by volcanism under contrast geological conditions. The development of such contrast in the depositional sequences reflects variation in the accommodation to sediment supply in the same accumulation space inside the depocenters during the rifting of the Abu Treifiya Basin. Hydrothermal mineralizations comprising quartz and carbonate are restricted to peperites and lava flows.

Simultaneous leaching of arsenite, arsenate, selenite and selenate, and their migration in tunnel-excavated sedimentary rocks: I. Column experiments under intermittent and unsaturated flow.

PubMed

Tabelin, Carlito Baltazar; Sasaki, Ryosuke; Igarashi, Toshifumi; Park, Ilhwan; Tamoto, Shuichi; Arima, Takahiko; Ito, Mayumi; Hiroyoshi, Naoki

2017-11-01

Rocks excavated in tunnel construction projects for roads and railways throughout Japan often leached out hazardous trace elements like arsenic (As) and selenium (Se) upon their exposure to the environment. In nature, the various oxyanionic species of As and Se not only coexist but also exhibit contrasting adsorption-desorption behaviors, so speciation is a crucial factor in their migration through natural geologic media. In this study, the leaching and transport of arsenite (As III ), arsenate (As V ), selenite (Se IV ) and selenate (Se VI ) in four tunnel-excavated rocks from the Cretaceous-Paleocene Yezo forearc basin were investigated using laboratory column experiments supplemented by batch leaching experiments. The single- and consecutive-batch leaching results revealed that As III , As V , Se IV and Se VI were released simultaneously, which could be attributed to the rapid dissolution of trace evaporite salts found in the rocks. Arsenic in the leachates was also predominated by As V while Se IV and Se VI concentrations were nearly equal, which are both consistent with predictions of equilibrium Eh-pH diagrams. Under intermittent and unsaturated flow, however, periods when As III and Se VI predominated in the effluents were observed. Spatial distributions of As and Se species with depth at the end of the column experiments suggest that migrations of As III , As V and Se IV were delayed, the extent of which depended on the rock. These results indicate that migration and speciation of As and Se in the rocks are controlled by preferential adsorption-desorption reactions, the effects of which were most probably magnified by changes in the pH and concentrations of coexisting ions due to intermittent and unsaturated flow. Copyright © 2017 Elsevier Ltd. All rights reserved.

Regulation of DNA conformations and dynamics in flows with hybrid field microfluidics.

PubMed

Ren, Fangfang; Zu, Yingbo; Kumar Rajagopalan, Kartik; Wang, Shengnian

2012-01-01

Visualizing single DNA dynamics in flow provides a wealth of physical insights in biophysics and complex flow study. However, large signal fluctuations, generated from diversified conformations, deformation history dependent dynamics and flow induced stochastic tumbling, often frustrate its wide adoption in single molecule and polymer flow study. We use a hybrid field microfluidic (HFM) approach, in which an electric field is imposed at desired locations and appropriate moments to balance the flow stress on charged molecules, to effectively regulate the initial conformations and the deformation dynamics of macromolecules in flow. With λ-DNA and a steady laminar shear flow as the model system, we herein studied the performance of HFM on regulating DNA trapping, relaxation, coil-stretch transition, and accumulation. DNA molecules were found to get captured in the focused planes when motions caused by flow, and the electric field were balanced. The trapped macromolecules relaxed in two different routes while eventually became more uniform in size and globule conformations. When removing the electric field, the sudden stretching dynamics of DNA molecules exhibited a more pronounced extension overshoot in their transient response under a true step function of flow stress while similar behaviors to what other pioneering work in steady shear flow. Such regulation strategies could be useful to control the conformations of other important macromolecules (e.g., proteins) and help better reveal their molecular dynamics.

Can a simple dynamical system describe the interplay between drag and buoyancy in terrain-induced canopy flows?

NASA Astrophysics Data System (ADS)

De Roo, Frederik; Banerjee, Tirtha

2017-04-01

Under non-neutral conditions and in the presence of topography the dynamics of turbulent flow within a canopy is not yet completely understood. This has implications for the measurement of surface-atmosphere exchange by means of eddy-covariance. For example the measurement of carbon dioxide fluxes are strongly influenced if drainage flows happen during night, when the flow within the canopy decouples from the flow aloft. In the present work, we investigate the dynamics of terrain-induced turbulent flow within sloped canopies. We concentrate on the presence of oscillatory behavior in the flow variables in terms of switching of flow regimes by conducting linear stability analysis. We revisit and correct the simplified theory that exists in the literature, which is based on the interplay between the drag force and the buoyancy. We find that the simplified description of this dynamical system cannot exhibit the observed richness of the dynamics. To tackle the full spatiotemporal dynamical system theoretically is beyond the scope of this work, although we can make some qualitative arguments. Additionally, we make use of large-eddy simulation of a three-dimensional hill covered by a homogeneous forest and analyze phase synchronization behavior of the major terms in the momentum budget to explore the turbulent dynamics in more detail.

Characterization of the homologs of flerovium with crown ether based extraction chromatography resins: studies in nitric acid

DOE PAGES

Despotopulos, John D.; Kmak, Kelly N.; Gharibyan, Narek; ...

2016-09-17

Eichrom’s Pb resin, a crown-ether-based extraction chromatography resin, was characterized for separation of the flerovium (Fl) homologs, Pb and Sn. Batch uptake of Pb(II) and Sn(IV) radionuclides was determined from an HNO 3 matrix. Pb(II) was strongly retained on the resin at all HNO 3 concentrations, while Sn(IV) showed no uptake. Extraction kinetics for Pb(II) were examined and show suitable uptake on the second time scale. Here, separation methods for the isolation of individual homologs, Pb(II) and Sn(IV), have been established using 2 mL pre-packed vacuum flow Pb resin columns.

40 CFR 98.426 - Data reporting requirements.

Code of Federal Regulations, 2012 CFR

2012-07-01

... flow meter in your process chain in relation to the points of CO2 stream capture, dehydration... concentration. (7) The location of the flow meter in your process chain in relation to the points of CO2 stream... meter(s) in metric tons. (iii) The total annual CO2 mass supplied in metric tons. (iv) The location of...

40 CFR 98.426 - Data reporting requirements.

Code of Federal Regulations, 2013 CFR

2013-07-01

... flow meter in your process chain in relation to the points of CO2 stream capture, dehydration... concentration. (7) The location of the flow meter in your process chain in relation to the points of CO2 stream... meter(s) in metric tons. (iii) The total annual CO2 mass supplied in metric tons. (iv) The location of...

40 CFR 98.426 - Data reporting requirements.

Code of Federal Regulations, 2011 CFR

2011-07-01

... flow meter in your process chain in relation to the points of CO2 stream capture, dehydration... concentration. (7) The location of the flow meter in your process chain in relation to the points of CO2 stream... meter(s) in metric tons. (iii) The total annual CO2 mass supplied in metric tons. (iv) The location of...

A Flow Visualization Study of Laminar/Turbulent Transition in a Curved Channel

DTIC Science & Technology

1987-03-01

convected down- stream, to deform as shown in Figure 16. One possible arrangement of velocity vectors in the radial plane which could cause such a...Re 2231 KODAK RECORDING FEILD ASA 1,000 (f2.8, B) 10 ....... .... . . . . . . .. Figure C.33 IV-4 2100-2330 15 FEB 1987 8.0 % FLOW (rotameter) MEAN

Pediatric head and neck lesions: assessment of vascularity by MR digital subtraction angiography.

PubMed

Chooi, Weng Kong; Woodhouse, Neil; Coley, Stuart C; Griffiths, Paul D

2004-08-01

Pediatric head and neck lesions can be difficult to characterize on clinical grounds alone. We investigated the use of dynamic MR digital subtraction angiography as a noninvasive adjunct for the assessment of the vascularity of these abnormalities. Twelve patients (age range, 2 days to 16 years) with known or suspected vascular abnormalities were studied. Routine MR imaging, time-of-flight MR angiography, and MR digital subtraction angiography were performed in all patients. The dynamic sequence was acquired in two planes at one frame per second by using a thick section (6-10 cm) selective radio-frequency spoiled fast gradient-echo sequence and an IV administered bolus of contrast material. The images were subtracted from a preliminary mask sequence and viewed as a video-inverted cine loop. In all cases, MR digital subtraction angiography was successfully performed. The technique showed the following: 1) slow flow lesions (two choroidal angiomas, eyelid hemangioma, and scalp venous malformation); 2) high flow lesions that were not always suspected by clinical examination alone (parotid hemangioma, scalp, occipital, and eyelid arteriovenous malformations plus a palatal teratoma); 3) a hypovascular tumor for which a biopsy could be safely performed (Burkitt lymphoma); and 4) a hypervascular tumor of the palate (cystic teratoma). Our early experience suggests that MR digital subtraction angiography can be reliably performed in children of all ages without complication. The technique provided a noninvasive assessment of the vascularity of each lesion that could not always have been predicted on the basis of clinical examination or routine MR imaging alone.

Dynamic Contrast-Enhanced Ultrasound Identifies Microcirculatory Alterations in Sepsis-Induced Acute Kidney Injury.

PubMed

Lima, Alexandre; van Rooij, Tom; Ergin, Bulent; Sorelli, Michele; Ince, Yasin; Specht, Patricia A C; Mik, Egbert G; Bocchi, Leonardo; Kooiman, Klazina; de Jong, Nico; Ince, Can

2018-05-15

We developed quantitative methods to analyze microbubble kinetics based on renal contrast-enhanced ultrasound imaging combined with measurements of sublingual microcirculation on a fixed area to quantify early microvascular alterations in sepsis-induced acute kidney injury. Prospective controlled animal experiment study. Hospital-affiliated animal research institution. Fifteen female pigs. The animals were instrumented with a renal artery flow probe after surgically exposing the kidney. Nine animals were given IV infusion of lipopolysaccharide to induce septic shock, and six were used as controls. Contrast-enhanced ultrasound imaging was performed on the kidney before, during, and after having induced shock. Sublingual microcirculation was measured continuously using the Cytocam on the same spot. Contrast-enhanced ultrasound effectively allowed us to develop new analytical methods to measure dynamic variations in renal microvascular perfusion during shock and resuscitation. Renal microvascular hypoperfusion was quantified by decreased peak enhancement and an increased ratio of the final plateau intensity to peak enhancement. Reduced intrarenal blood flow could be estimated by measuring the microbubble transit times between the interlobar arteries and capillary vessels in the renal cortex. Sublingual microcirculation measured using the Cytocam in a fixed area showed decreased functional capillary density associated with plugged sublingual capillary vessels that persisted during and after fluid resuscitation. In our lipopolysaccharide model, with resuscitation targeted at blood pressure, the contrast-enhanced ultrasound imaging can identify renal microvascular alterations by showing prolonged contrast enhancement in microcirculation during shock, worsened by resuscitation with fluids. Concomitant analysis of sublingual microcirculation mirrored those observed in the renal microcirculation.

Bacterial population dynamics during uranium reduction andre-oxidation: Application of a novel high density oligonucleotidemicroarray approach

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brodie, Eoin L.; DeSantis, Todd Z.; Joyner, Dominique C.

2006-01-30

Reduction of soluble uranium U(VI) to less-soluble uraniumU(IV) is a promising approach to minimize migration from contaminatedaquifers. It is generally assumed that, under constant reducingconditions, U(IV) is stable and immobile; however, in a previous study,we documented reoxidation of U(IV) under continuous reducing conditions(Wan et al., Environ. Sci. Technol. 2005, 39:6162 6169). To determine ifchanges in microbial community composition were a factor in U(IV)reoxidation, we employed a high-density phylogenetic DNA microarray (16Smicroarray) containing 500,000 probes to monitor changes in bacterialpopulations during this remediation process. Comparison of the 16Smicroarray with clone libraries demonstrated successful detection andclassification of most clone groups. Analysis ofmore » the most dynamic groupsof 16S rRNA gene amplicons detected by the 16S microarray identified fiveclusters of bacterial subfamilies responding in a similar manner. Thisapproach demonstrated that amplicons of known metal-reducing bacteriasuch as Geothrix fermentans (confirmed by quantitative PCR) and thosewithin the Geobacteraceae were abundant during U(VI) reduction and didnot decline during the U(IV) reoxidation phase. Significantly, it appearsthat the observed reoxidation of uranium under reducing conditionsoccurred despite elevated microbial activity and the consistent presenceof metal-reducing bacteria. High-density phylogenetic microarraysconstitute a powerful tool, enabling the detection and monitoring of asubstantial portion of the microbial population in a routine, accurate,and reproducible manner.« less

Mathematical Relationships between Neuron Morphology and Neurite Growth Dynamics in Drosophila melanogaster Larva Class IV Sensory Neurons

NASA Astrophysics Data System (ADS)

Ganguly, Sujoy; Liang, Xin; Grace, Michael; Lee, Daniel; Howard, Jonathon

The morphology of neurons is diverse and reflects the diversity of neuronal functions, yet the principles that govern neuronal morphogenesis are unclear. In an effort to better understand neuronal morphogenesis we will be focusing on the development of the dendrites of class IV sensory neuron in Drosophila melanogaster. In particular we attempt to determine how the the total length, and the number of branches of dendrites are mathematically related to the dynamics of neurite growth and branching. By imaging class IV neurons during early embryogenesis we are able to measure the change in neurite length l (t) as a function of time v (t) = dl / dt . We found that the distribution of v (t) is well characterized by a hyperbolic secant distribution, and that the addition of new branches per unit time is well described by a Poisson process. Combining these measurements with the assumption that branching occurs with equal probability anywhere along the dendrite we were able to construct a mathematical model that provides reasonable agreement with the observed number of branches, and total length of the dendrites of the class IV sensory neuron.

Radiative Reverse Shock Laser Experiments Relevant to Accretion Processes in Cataclysmic Variables

NASA Astrophysics Data System (ADS)

Krauland, Christine

2012-10-01

We present results from experiments that explore radiative reverse shock waves and their contribution to the evolving dynamics of the cataclysmic variable (CV) system in which they reside. CVs are close binary star systems containing a white dwarf (WD) that accretes matter from its late-type main sequence companion star. In the process of accretion, a reverse shock forms when the supersonic infalling plasma is impeded. It provides the main source of radiation in the binary systems. In the case of a non-magnetic CV, the impact on an accretion disk produces this ``hot spot,'' where the flow obliquely strikes the rotating accretion disk. This collision region has many ambiguities as a radiation hydrodynamic system, but shock development in the infalling flow can be modeled [1]. We discuss the production of radiative reverse shocks in experiments at the Omega-60 laser facility. The ability of this high-intensity laser to create large energy densities in targets having millimeter-scale volumes makes it feasible to create supersonic plasma flows. Obtaining a radiative reverse shock in the laboratory requires a sufficiently fast flow (> 60 km/s) within a material whose opacity is large enough to produce energetically significant emission from experimentally achievable layers. We will show the radiographic and emission data from three campaigns on Omega-60 with accompanying CRASH [2] simulations, and will discuss the implications in the context of the CV system. [4pt] [1] Armitage, P. J. and Livio, M., ApJ, 493, 898 (1998).[0pt] [2] van der Holst, B., Toth, G., Sokolov, I.V., et al., ApJS, 194, 23 (2011).

Dynamic switching enables efficient bacterial colonization in flow.

PubMed

Kannan, Anerudh; Yang, Zhenbin; Kim, Minyoung Kevin; Stone, Howard A; Siryaporn, Albert

2018-05-22

Bacteria colonize environments that contain networks of moving fluids, including digestive pathways, blood vasculature in animals, and the xylem and phloem networks in plants. In these flow networks, bacteria form distinct biofilm structures that have an important role in pathogenesis. The physical mechanisms that determine the spatial organization of bacteria in flow are not understood. Here, we show that the bacterium P. aeruginosa colonizes flow networks using a cyclical process that consists of surface attachment, upstream movement, detachment, movement with the bulk flow, and surface reattachment. This process, which we have termed dynamic switching, distributes bacterial subpopulations upstream and downstream in flow through two phases: movement on surfaces and cellular movement via the bulk. The model equations that describe dynamic switching are identical to those that describe dynamic instability, a process that enables microtubules in eukaryotic cells to search space efficiently to capture chromosomes. Our results show that dynamic switching enables bacteria to explore flow networks efficiently, which maximizes dispersal and colonization and establishes the organizational structure of biofilms. A number of eukaryotic and mammalian cells also exhibit movement in two phases in flow, which suggests that dynamic switching is a modality that enables efficient dispersal for a broad range of cell types.

Determination of Plutonium Isotope Ratios at Very Low Levels by ICP-MS using On-Line Electrochemically Modulated Separations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liezers, Martin; Lehn, Scott A; Olsen, Khris B

2009-10-01

Electrochemically modulated separations (EMS) are shown to be a rapid and selective means of extracting and concentrating Pu from complex solutions prior to isotopic analysis by inductively coupled plasma mass spectrometry (ICP-MS). This separation is performed in a flow injection mode, on-line with the ICP-MS. A three-electrode, flow-by electrochemical cell is used to accumulate Pu at an anodized glassy carbon electrode by redox conversion of Pu(III) to Pu (IV&VI). The entire process takes place in 2% v/v (0.46M) HNO 3. No redox chemicals or acid concentration changes are required. Plutonium accumulation and release is redox dependent and controlled by themore » applied cell potential. Thus large transient volumetric concentration enhancements can be achieved. Based on more negative U(IV) potentials relative to Pu(IV), separation of Pu from uranium is efficient, thereby eliminating uranium hydride interferences. EMS-ICP-MS isotope ratio measurement performance will be presented for femtogram to attogram level plutonium concentrations.« less

Pore-Scale Characterization of Biogeochemical Controls on Iron and Uranium Speciation under Flow Conditions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pearce, Carolyn I.; Wilkins, Michael J.; Zhang, Changyong

2012-09-17

Etched silicon microfluidic pore network models (micromodels) with controlled chemical and redox gradients, mineralogy, and microbiology under continuous flow conditions are used for the incremental development of complex microenvironments that simulate subsurface conditions. We demonstrate the colonization of micromodel pore spaces by an anaerobic Fe(III)-reducing bacterial species (Geobacter sulfurreducens) and the enzymatic reduction of a bioavailable Fe(III) phase within this environment. Using both X-ray Microprobe and X-ray Absorption Spectroscopy, we investigate the combined effects of the precipitated Fe(III) phases and the microbial population on uranium biogeochemistry under flow conditions. Precipitated Fe(III) phases within the micromodel were most effectively reduced inmore » the presence of an electron shuttle (AQDS), and Fe(II) ions adsorbed onto the precipitated mineral surface without inducing any structural change. In the absence of Fe(III), U(VI) was effectively reduced by the microbial population to insoluble U(IV), which was precipitated in discrete regions associated with biomass. In the presence of Fe(III) phases, however, both U(IV) and U(VI) could be detected associated with biomass, suggesting re-oxidation of U(IV) by localized Fe(III) phases. These results demonstrate the importance of the spatial localization of biomass and redox active metals, and illustrate the key effects of pore-scale processes on contaminant fate and reactive transport.« less

Dynamic Modeling Strategy for Flow Regime Transition in Gas-Liquid Two-Phase Flows

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xia Wang; Xiaodong Sun; Benjamin Doup

In modeling gas-liquid two-phase flows, the concept of flow regimes has been widely used to characterize the global interfacial structure of the flows. Nearly all constitutive relations that provide closures to the interfacial transfers in two-phase flow models, such as the two-fluid model, are flow regime dependent. Current nuclear reactor safety analysis codes, such as RELAP5, classify flow regimes using flow regime maps or transition criteria that were developed for steady-state, fully-developed flows. As twophase flows are dynamic in nature, it is important to model the flow regime transitions dynamically to more accurately predict the two-phase flows. The present workmore » aims to develop a dynamic modeling strategy to determine flow regimes in gas-liquid two-phase flows through introduction of interfacial area transport equations (IATEs) within the framework of a two-fluid model. The IATE is a transport equation that models the interfacial area concentration by considering the creation of the interfacial area, fluid particle (bubble or liquid droplet) disintegration, boiling and evaporation, and the destruction of the interfacial area, fluid particle coalescence and condensation. For flow regimes beyond bubbly flows, a two-group IATE has been proposed, in which bubbles are divided into two groups based on their size and shapes, namely group-1 and group-2 bubbles. A preliminary approach to dynamically identify the flow regimes is discussed, in which discriminator s are based on the predicted information, such as the void fraction and interfacial area concentration. The flow regime predicted with this method shows good agreement with the experimental observations.« less

Velocity measurements of heterogeneous RBC flow in capillary vessels using dynamic laser speckle signal.

PubMed

Li, Chenxi; Wang, Ruikang

2017-04-01

We propose an approach to measure heterogeneous velocities of red blood cells (RBCs) in capillary vessels using full-field time-varying dynamic speckle signals. The approach utilizes a low coherent laser speckle imaging system to record the instantaneous speckle pattern, followed by an eigen-decomposition-based filtering algorithm to extract dynamic speckle signal due to the moving RBCs. The velocity of heterogeneous RBC flows is determined by cross-correlating the temporal dynamic speckle signals obtained at adjacent locations. We verify the approach by imaging mouse pinna in vivo, demonstrating its capability for full-field RBC flow mapping and quantifying flow pattern with high resolution. It is expected to investigate the dynamic action of RBCs flow in capillaries under physiological changes.

Stage-by-Stage and Parallel Flow Path Compressor Modeling for a Variable Cycle Engine

NASA Technical Reports Server (NTRS)

Kopasakis, George; Connolly, Joseph W.; Cheng, Larry

2015-01-01

This paper covers the development of stage-by-stage and parallel flow path compressor modeling approaches for a Variable Cycle Engine. The stage-by-stage compressor modeling approach is an extension of a technique for lumped volume dynamics and performance characteristic modeling. It was developed to improve the accuracy of axial compressor dynamics over lumped volume dynamics modeling. The stage-by-stage compressor model presented here is formulated into a parallel flow path model that includes both axial and rotational dynamics. This is done to enable the study of compressor and propulsion system dynamic performance under flow distortion conditions. The approaches utilized here are generic and should be applicable for the modeling of any axial flow compressor design.

High dose naloxone does not improve cerebral or myocardial blood flow during cardiopulmonary resuscitation in pigs.

PubMed

Gervais, H W; Eberle, B; Hennes, H J; Grimm, W; Kilian, A; Konietzke, D; Massing, C; Dick, W

1997-06-01

In a prospective, randomized, placebo-controlled, double-blind trial we tested the hypothesis that naloxone given during cardiopulmonary resuscitation (CPR) enhances cerebral and myocardial blood flow. Twenty-one anesthetized, normoventilated pigs were instrumented for measurements of right atrial and aortic pressures, and regional organ blood flow (radiolabeled microspheres). After 5 min of untreated fibrillatory arrest, CPR was commenced using a pneumatic chest compressor/ventilator. With onset of CPR, an i.v. bolus of 40 micrograms/kg b.w. of epinephrine was given, followed by an infusion of 0.4 micrograms/kg per min. After 5 min of CPR, either naloxone, 10 mg/kg b.w. (group N, n = 11) or normal saline (group S, n = 10) was given i.v. Prior to, and after 1, 15, and 30 min of CPR, hemodynamic and blood flow measurements were obtained. After 30 min of CPR, mean arterial pressure was significantly higher in group N (26 +/- 5 vs. 13 +/- 3 mmHg, P < 0.05). Groups did not differ with respect to myocardial perfusion pressure or arterial blood gases at any time during the observation period. Regional brain and heart blood flows were not different between N and S at any point of measurement. We conclude that high-dose naloxone does not augment cerebral or myocardial blood flow during prolonged closed-chest CPR.

Medication and volume delivery by gravity-driven micro-drip intravenous infusion: potential variations during "wide-open" flow.

PubMed

Pierce, Eric T; Kumar, Vikram; Zheng, Hui; Peterfreund, Robert A

2013-03-01

Gravity-driven micro-drip infusion sets allow control of medication dose delivery by adjusting drops per minute. When the roller clamp is fully open, flow in the drip chamber can be a continuous fluid column rather than discrete, countable, drops. We hypothesized that during this "wide-open" state, drug delivery becomes dependent on factors extrinsic to the micro-drip set and is therefore difficult to predict. We conducted laboratory experiments to characterize volume delivery under various clinically relevant conditions of wide-open flow in an in vitro laboratory model. A micro-drip infusion set, plugged into a bag of normal saline, was connected to a high-flow stopcock at the distal end. Vertically oriented IV catheters (gauges 14-22) were connected to the stopcock. The fluid meniscus height in the bag was fixed (60-120 cm) above the outflow point. The roller clamp on the infusion set was in fully open position for all experiments resulting in a continuous column of fluid in the drip chamber. Fluid volume delivered in 1 minute was measured 4 times with each condition. To model resistive effects of carrier flow, volumetric infusion pumps were used to deliver various flow rates of normal saline through a carrier IV set into which a micro-drip infusion was "piggybacked." We also compared delivery by micro-drip infusion sets from 3 manufacturers. The volume of fluid delivered by gravity-driven infusion under wide-open conditions (continuous fluid column in drip chamber) varied 2.9-fold (95% confidence interval, 2.84-2.96) depending on catheter size and fluid column height. Total model resistance of the micro-drip with stopcock and catheter varied with flow rate. Volume delivered by the piggybacked micro-drip decreased up to 29.7% ± 0.8% (mean ± SE) as the carrier flow increased from 0 to 1998 mL/min. Delivery characteristics of the micro-drip infusion sets from 3 different manufacturers were similar. Laboratory simulation of clinical situations with gravity-driven micro-drip infusion sets under wide-open flow conditions revealed that infusion rate (drug and/or volume delivery) can vary widely depending on extrinsic factors including catheter size, fluid column height, and carrier flow. The variable resistance implies nonlaminar flow in the micro-drip model that cannot be easily predicted mathematically. These findings support the use of mechanical pumps instead of gravity-driven micro-drips to enhance the precision and safety of IV infusions, especially for vasoactive drugs.

LOW-VELOCITY COMPRESSIBLE FLOW THEORY

EPA Science Inventory

The widespread application of incompressible flow theory dominates low-velocity fluid dynamics, virtually preventing research into compressible low-velocity flow dynamics. Yet, compressible solutions to simple and well-defined flow problems and a series of contradictions in incom...

Comparative Dynamics of Retrograde Actin Flow and Focal Adhesions: Formation of Nascent Adhesions Triggers Transition from Fast to Slow Flow

PubMed Central

Alexandrova, Antonina Y.; Arnold, Katya; Schaub, Sébastien; Vasiliev, Jury M.; Meister, Jean-Jacques; Bershadsky, Alexander D.; Verkhovsky, Alexander B.

2008-01-01

Dynamic actin network at the leading edge of the cell is linked to the extracellular matrix through focal adhesions (FAs), and at the same time it undergoes retrograde flow with different dynamics in two distinct zones: the lamellipodium (peripheral zone of fast flow), and the lamellum (zone of slow flow located between the lamellipodium and the cell body). Cell migration involves expansion of both the lamellipodium and the lamellum, as well as formation of new FAs, but it is largely unknown how the position of the boundary between the two flow zones is defined, and how FAs and actin flow mutually influence each other. We investigated dynamic relationship between focal adhesions and the boundary between the two flow zones in spreading cells. Nascent FAs first appeared in the lamellipodium. Within seconds after the formation of new FAs, the rate of actin flow decreased locally, and the lamellipodium/lamellum boundary advanced towards the new FAs. Blocking fast actin flow with cytochalasin D resulted in rapid dissolution of nascent FAs. In the absence of FAs (spreading on poly-L-lysine-coated surfaces) retrograde flow was uniform and the velocity transition was not observed. We conclude that formation of FAs depends on actin dynamics, and in its turn, affects the dynamics of actin flow by triggering transition from fast to slow flow. Extension of the cell edge thus proceeds through a cycle of lamellipodium protrusion, formation of new FAs, advance of the lamellum, and protrusion of the lamellipodium from the new base. PMID:18800171

Multiscale Modeling of Multiphase Fluid Flow

DTIC Science & Technology

2016-08-01

the disparate time and length scales involved in modeling fluid flow and heat transfer. Molecular dynamics simulations were carried out to provide a...fluid dynamics methods were used to investigate the heat transfer process in open-cell micro-foam with phase change material; enhancement of natural...Computational fluid dynamics, Heat transfer, Phase change material in Micro-foam, Molecular Dynamics, Multiphase flow, Multiscale modeling, Natural

46 CFR 162.060-26 - Land-based testing requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

.... (iv) The manufacturer of the BWMS must demonstrate by using mathematical modeling, computational fluid dynamics modeling, and/or by calculations, that any downscaling will not affect the ultimate functioning... mathematical and computational fluid dynamics modeling) must be clearly identified in the Experimental Design...

46 CFR 162.060-26 - Land-based testing requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

.... (iv) The manufacturer of the BWMS must demonstrate by using mathematical modeling, computational fluid dynamics modeling, and/or by calculations, that any downscaling will not affect the ultimate functioning... mathematical and computational fluid dynamics modeling) must be clearly identified in the Experimental Design...

46 CFR 162.060-26 - Land-based testing requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

.... (iv) The manufacturer of the BWMS must demonstrate by using mathematical modeling, computational fluid dynamics modeling, and/or by calculations, that any downscaling will not affect the ultimate functioning... mathematical and computational fluid dynamics modeling) must be clearly identified in the Experimental Design...

Inertia critical layers and their impacts on nongeostrophic baroclinic instability

NASA Astrophysics Data System (ADS)

Shen, Bo-Wen

We investigate the effects of critical levels (CLs) on a baroclinic flow over mountains, nongeostrophic (NG) inertia critical layer instability, and NG baroclinic instability (BI) in a three-layer atmosphere with a small Richardson number (Ri) in the middle layer. We develop a numerical wave decomposition method in Chapter 2, which is found to be useful in determining the reflection coefficient (Ref) numerically when the flow system is too complicated to obtain Ref analytically. Effects of CLs on flow over mountains are studied both analytically and numerically in Chapter 3. We define the effective inertia critical level (ICL) as the height above which inertia-gravity waves attenuate significantly. Based on numerical simulations with a broad range of Rossby number (Ro) and Ri, four wave regimes are found: (a) Regime I: inertia- gravity waves. The flow behaves like unsheared inertia- gravity waves and the effective lower ICL plays a similar role as the classical critical level (CCL) does in a nonrotating flow. (b) Regime II: combined inertia-gravity waves and baroclinic lee waves. These waves behave like those in Regime I below the lower effective ICL, and like baroclinic lee waves near the CCL. (c) Regime III: combined evanescent and baroclinic lee waves. These waves still behave like baroclinic lee waves near the CCL, but are trapped near the surface. (d) Regime IV: transient waves. NG baroclinic instability exists, as evidenced by the positive domain-averaged north-south heat flux. Wave regime IV is further investigated in Chapter 5. We identify the NG baroclinic instability in Chapter 3 as an inertia critical layer (ICLY) instability. The role of the upper inertia critical level in this instability has been studied by choosing a periodic mountain. When only the CCL and upper ICL are present in the domain, the mesoscale ICLY instability tends to occur. For a periodic mountain ridge, the ICLY instability selects the mountain's tvavelength as its wavelength of maximum growth. For an isolated mountain ridge, the NG baroclinic lee wave is established in the beginning for flows with small Ri, which then develops its own upper ICL. The stability of Lindzen and Tung's (1976, hereafter LT76) type of three-layer nonrotating/rotating atmosphere is discussed in Chapter 6. We first investigate the transient dynamics of wave ducting by a numerical model. The adjustment time for waves to be ducted depends on the atmospheric structure and horizontal wavelength. Second, we study the effects of Coriolis force on LT76's wave ducting mechanism, and show that a wave with wavelength on the order of 100 km is hardly ducted. (Abstract shortened by UMI.)

Early first trimester uteroplacental flow and the progressive disintegration of spiral artery plugs: new insights from contrast-enhanced ultrasound and tissue histopathology.

PubMed

Roberts, V H J; Morgan, T K; Bednarek, P; Morita, M; Burton, G J; Lo, J O; Frias, A E

2017-12-01

Does the use of a vascular contrast agent facilitate earlier detection of maternal flow to the placental intervillous space (IVS) in the first trimester of pregnancy? Microvascular filling of the IVS was demonstrated by contrast-enhanced ultrasound from 6 weeks of gestation onwards, earlier than previously believed. During placental establishment and remodeling of maternal spiral arteries, endovascular trophoblast cells invade and accumulate in the lumen of these vessels to form 'trophoblast plugs'. Prior evidence from morphological and Doppler ultrasound studies has been conflicting as to whether the spiral arteries are completely plugged, preventing maternal blood flow to the IVS until late in the first trimester. Uteroplacental flow was examined across the first trimester in human subjects given an intravenous infusion of lipid-shelled octofluoropropane microbubbles with ultrasound measurement of destruction and replenishment kinetics. We also performed a comprehensive histopathological correlation using two separately archived uteroplacental tissue collections to evaluate the degree of spiral artery plugging and evaluate remodeling of the upstream myometrial radial and arcurate arteries. Pregnant women (n = 34) were recruited in the first trimester (range: 6+3 to 13+6 weeks gestation) for contrast-enhanced ultrasound studies with destruction-replenishment analysis of signal intensity for assessment of microvascular flux rate. Histological samples from archived in situ (Boyd Collection, n = 11) and fresh first, second, and third trimester decidual and post-hysterectomy uterine specimens (n = 16) were evaluated by immunohistochemistry (using markers of epithelial, endothelial and T-cells, as well as cell adhesion and proliferation) and ultrastructural analysis. Contrast agent entry into the IVS was visualized as early as 6+3 weeks of gestation with some variability in microvascular flux rate noted in the 6-7+6 week samples. Spiral artery plug canalization was observed from 7 weeks with progressive disintegration thereafter. Of note, microvascular flux rate did not progressively increase until 13 weeks, which suggests that resistance to maternal flow in the early placenta may be mediated more proximally by myometrial radial arteries that begin remodeling at the end of the first trimester. Gestational age was determined by crown-rump length measurements obtained by transvaginal ultrasound on the day of contrast-enhanced imaging studies, which may explain the variability in the earliest gestational age samples due to the margin of error in this type of measurement. Our comprehensive in situ histological analysis, in combination with the use of an in vivo imaging modality that has the sensitivity to permit visualization of microvascular filling, has allowed us to reveal new evidence in support of increasing blood flow to the IVS from 6 weeks of gestation. Histologic review suggested the mechanism may be blood flow through capillary-sized channels that form through the loosely cohesive 'plugs' by 7 weeks gestation. However, spiral artery remodeling on its own did not appear to explain why there is significantly more blood flow at 13 weeks gestation. Histologic studies suggest it may be related to radial artery remodeling, which begins at the end of the first trimester. This project was supported by the Oregon Health and Science University Knight Cardiovascular Institute, Center for Developmental Health and the Struble Foundation. There are no competing interests. © The Author 2017. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

FLOW FIELD IN SUPERSONIC MIXED-COMPRESSION INLETS AT ANGLE OF ATTACK USING THE THREE DIMENSIONAL METHOD OF CHARACTERISTICS WITH DISCRETE SHOCK WAVE FITTING

NASA Technical Reports Server (NTRS)

Bishop, A. R.

1994-01-01

This computer program calculates the flow field in the supersonic portion of a mixed-compression aircraft inlet at non-zero angle of attack. This approach is based on the method of characteristics for steady three-dimensional flow. The results of this program agree with those produced by the two-dimensional method of characteristics when axisymmetric flow fields are calculated. Except in regions of high viscous interaction and boundary layer removal, the results agree well with experimental data obtained for threedimensional flow fields. The flow field in a variety of axisymmetric mixed compression inlets can be calculated using this program. The bow shock wave and the internal shock wave system are calculated using a discrete shock wave fitting procedure. The internal flow field can be calculated either with or without the discrete fitting of the internal shock wave system. The influence of molecular transport can be included in the calculation of the external flow about the forebody and in the calculation of the internal flow when internal shock waves are not discretely fitted. The viscous and thermal diffussion effects are included by treating them as correction terms in the method of characteristics procedure. Dynamic viscosity is represented by Sutherland's law and thermal conductivity is represented as a quadratic function of temperature. The thermodynamic model used is that of a thermally and calorically perfect gas. The program assumes that the cowl lip is contained in a constant plane and that the centerbody contour and cowl contour are smooth and have continuous first partial derivatives. This program cannot calculate subsonic flow, the external flow field if the bow shock wave does not exist entirely around the forebody, or the internal flow field if the bow flow field is injected into the annulus. Input to the program consists of parameters to control execution, to define the geometry, and the vehicle orientation. Output consists of a list of parameters used, solution planes, and a description of the shock waves. This program is written in FORTRAN IV for batch execution and has been implemented on a CDC 6000 series machine with a central memory requirement of 110K (octal) of 60 bit words when it is overlayed. This flow analysis program was developed in 1978.

Metal-Insulator-Semiconductor Diode Consisting of Two-Dimensional Nanomaterials.

PubMed

Jeong, Hyun; Oh, Hye Min; Bang, Seungho; Jeong, Hyeon Jun; An, Sung-Jin; Han, Gang Hee; Kim, Hyun; Yun, Seok Joon; Kim, Ki Kang; Park, Jin Cheol; Lee, Young Hee; Lerondel, Gilles; Jeong, Mun Seok

2016-03-09

We present a novel metal-insulator-semiconductor (MIS) diode consisting of graphene, hexagonal BN, and monolayer MoS2 for application in ultrathin nanoelectronics. The MIS heterojunction structure was fabricated by vertically stacking layered materials using a simple wet chemical transfer method. The stacking of each layer was confirmed by confocal scanning Raman spectroscopy and device performance was evaluated using current versus voltage (I-V) and photocurrent measurements. We clearly observed better current rectification and much higher current flow in the MIS diode than in the p-n junction and the metal-semiconductor diodes made of layered materials. The I-V characteristic curve of the MIS diode indicates that current flows mainly across interfaces as a result of carrier tunneling. Moreover, we observed considerably high photocurrent from the MIS diode under visible light illumination.

Dynamics of Deformable Active Particles under External Flow Field

NASA Astrophysics Data System (ADS)

Tarama, Mitsusuke

2017-10-01

In most practical situations, active particles are affected by their environment, for example, by a chemical concentration gradient, light intensity, gravity, or confinement. In particular, the effect of an external flow field is important for particles swimming in a solvent fluid. For deformable active particles such as self-propelled liquid droplets and active vesicles, as well as microorganisms such as euglenas and neutrophils, a general description has been developed by focusing on shape deformation. In this review, we present our recent studies concerning the dynamics of a single active deformable particle under an external flow field. First, a set of model equations of active deformable particles including the effect of a general external flow is introduced. Then, the dynamics under two specific flow profiles is discussed: a linear shear flow, as the simplest example, and a swirl flow. In the latter case, the scattering dynamics of the active deformable particles by the swirl flow is also considered.

Optimizing Natural Gas Networks through Dynamic Manifold Theory and a Decentralized Algorithm: Belgium Case Study

NASA Astrophysics Data System (ADS)

Koch, Caleb; Winfrey, Leigh

2014-10-01

Natural Gas is a major energy source in Europe, yet political instabilities have the potential to disrupt access and supply. Energy resilience is an increasingly essential construct and begins with transmission network design. This study proposes a new way of thinking about modelling natural gas flow. Rather than relying on classical economic models, this problem is cast into a time-dependent Hamiltonian dynamics discussion. Traditional Natural Gas constraints, including inelastic demand and maximum/minimum pipe flows, are portrayed as energy functions and built into the dynamics of each pipe flow. Doing so allows the constraints to be built into the dynamics of each pipeline. As time progresses in the model, natural gas flow rates find the minimum energy, thus the optimal gas flow rates. The most important result of this study is using dynamical principles to ensure the output of natural gas at demand nodes remains constant, which is important for country to country natural gas transmission. Another important step in this study is building the dynamics of each flow in a decentralized algorithm format. Decentralized regulation has solved congestion problems for internet data flow, traffic flow, epidemiology, and as demonstrated in this study can solve the problem of Natural Gas congestion. A mathematical description is provided for how decentralized regulation leads to globally optimized network flow. Furthermore, the dynamical principles and decentralized algorithm are applied to a case study of the Fluxys Belgium Natural Gas Network.

Wigner flow reveals topological order in quantum phase space dynamics.

PubMed

Steuernagel, Ole; Kakofengitis, Dimitris; Ritter, Georg

2013-01-18

The behavior of classical mechanical systems is characterized by their phase portraits, the collections of their trajectories. Heisenberg's uncertainty principle precludes the existence of sharply defined trajectories, which is why traditionally only the time evolution of wave functions is studied in quantum dynamics. These studies are quite insensitive to the underlying structure of quantum phase space dynamics. We identify the flow that is the quantum analog of classical particle flow along phase portrait lines. It reveals hidden features of quantum dynamics and extra complexity. Being constrained by conserved flow winding numbers, it also reveals fundamental topological order in quantum dynamics that has so far gone unnoticed.

Enhanced chemiluminescence of cerium(IV)-Tween 85 system and the analytical application.

PubMed

Li, Shifeng; Qian, Li; Zhu, Yan; Liu, Manman; Gao, Yinping; Ni, Yonghong

2013-01-01

The oxidation reaction between cerium(IV) and Tween 85 in sulfuric acid medium produced weak chemiluminescence (CL). In this paper, it was found that citrate could strongly enhance the CL of cerium(IV)-Tween 85-polyphenol system. Based on studies of ultraviolet-visible spectra and CL spectra, the CL enhancement mechanism had been proposed. It was surmised that the light emission was from an excited oxygen molecular pair O2((1)Δg)O2((1)∑g(-)). The maximum emission wavelength was about 478 nm. The effects of 17 amino acids and 29 organic compounds on cerium(IV)-Tween 85-citrate CL were investigated by a flow injection procedure. This study showed the present system had a wide application for the determination of these compounds. Copyright © 2012 John Wiley & Sons, Ltd.

Nanomechanical resonators based on group IV element monolayers

NASA Astrophysics Data System (ADS)

He, Ji-Dong; Sun, Jia-Sheng; Jiang, Jin-Wu

2018-04-01

We perform molecular dynamics simulations to investigate the energy dissipation of the resonant oscillation for the group IV monolayers of puckered configuration, in which the oscillation is driven with different actuation velocities. We find that, in the moderate actuation velocity regime, the nonlinear coupling between the resonant oscillation mode and other high-frequency modes will lead to the non-resonant motion of the system. For the larger actuation velocity, the effective strain generated during the resonant oscillating causes a structural transition from the puckered configuration into the planar configuration, which is a characteristic energy dissipation mechanism for the resonant oscillation of these group IV puckered monolayers. Our findings shed light on mechanical applications of the group IV monolayers in the nanomechanical resonator field.

Velocity measurements of heterogeneous RBC flow in capillary vessels using dynamic laser speckle signal

PubMed Central

Li, Chenxi; Wang, Ruikang

2017-01-01

Abstract. We propose an approach to measure heterogeneous velocities of red blood cells (RBCs) in capillary vessels using full-field time-varying dynamic speckle signals. The approach utilizes a low coherent laser speckle imaging system to record the instantaneous speckle pattern, followed by an eigen-decomposition-based filtering algorithm to extract dynamic speckle signal due to the moving RBCs. The velocity of heterogeneous RBC flows is determined by cross-correlating the temporal dynamic speckle signals obtained at adjacent locations. We verify the approach by imaging mouse pinna in vivo, demonstrating its capability for full-field RBC flow mapping and quantifying flow pattern with high resolution. It is expected to investigate the dynamic action of RBCs flow in capillaries under physiological changes. PMID:28384709

Effects of step-feeding and intermittent aeration on organics and nitrogen removal in a horizontal subsurface flow constructed wetland.

PubMed

Patil, Sagar; Chakraborty, Saswati

2017-03-21

The effect of step feed strategy and intermittent aeration on removal of chemical oxygen demand (COD) and nitrogen was investigated in a laboratory scale horizontal subsurface flow constructed wetland (HSSFCW). Wetland was divided into four zones along the length (zone I to IV), and influent was introduced into first and third zones by step feeding. Continuous study was carried out in four phases. In phases I to III, 30% of influent was bypassed to zone III for denitrification along with organics removal. Intermittent aeration was provided only in zone II at 2.5 L/min for 4 h/day, during phases II, III and IV. In phase I, 87% COD and 43% NH 4 + -N (ammonia-nitrogen) removal were obtained from influents of 331 and 30 mg/L, respectively. In phase II study, external aeration resulted in 97% COD and 71% NH 4 + -N removal in the wetland. In phase IV, 40% of feed was delivered to zone III. Higher supply of organic in zone III resulted in higher denitrification, and total nitrogen removal rate increased to 70% from 56%. In the final effluent, concentration of NO 3 - -N was 9-11 mg/L in phase I to III and decreased to 4 mg/L in phase IV. Batch study showed that COD and NH 4 + -N removal followed first order kinetics in different zones of wetland.

10 CFR Appendix IV to Part 960 - Types of Information for the Nomination of Sites as Suitable for Characterization

Code of Federal Regulations, 2011 CFR

2011-01-01

... with its geologic setting, in order to estimate the pre-waste-emplacement ground-water flow conditions.... • Preliminary estimates of ground-water travel times along the likely flow paths from the repository to... hydrochemical conditions of the host rock, of the surrounding geohydrologic units, and along likely ground-water...

Historical Analysis of C-130E Resources

DTIC Science & Technology

1977-07-01

DOCUMENTATION SEARCH AND COLLECTION FLOW 24 DIAGRAM 6. DATA ANALYSIS FLOW DIAGRAM TASK IV 29 7. C-130 INVENTORY BY CONFIGURATION 40 8. C-130 MISSION...RESORCE RESOURCES....EOUCE .’." * ESURE :;. 400 ................... - ., -...... ’.. ... ".......... ... ’... ’" SYSTEM DESIGN PERFORMANCE 4 , OPERATIO ...Force inventory , the control of the human and material resources crosses several functions and commands. Seldom are the initial estimates verified

KRISSY: user's guide to modeling three-dimensional wind flow in complex terrain

Treesearch

Michael A. Fosberg; Michael L. Sestak

1986-01-01

KRISSY is a computer model for generating three-dimensional wind flows in complex terrain from data that were not or perhaps cannot be collected. The model is written in FORTRAN IV This guide describes data requirements, modeling, and output from an applications viewpoint rather than that of programming or theoretical modeling. KRISSY is designed to minimize...

Extracellular chloride signals collagen IV network assembly during basement membrane formation

PubMed Central

Cummings, Christopher F.; Pedchenko, Vadim; Brown, Kyle L.; Colon, Selene; Rafi, Mohamed; Jones-Paris, Celestial; Pokydeshava, Elena; Liu, Min; Pastor-Pareja, Jose C.; Stothers, Cody; Ero-Tolliver, Isi A.; McCall, A. Scott; Vanacore, Roberto; Bhave, Gautam; Santoro, Samuel; Blackwell, Timothy S.; Zent, Roy; Pozzi, Ambra

2016-01-01

Basement membranes are defining features of the cellular microenvironment; however, little is known regarding their assembly outside cells. We report that extracellular Cl− ions signal the assembly of collagen IV networks outside cells by triggering a conformational switch within collagen IV noncollagenous 1 (NC1) domains. Depletion of Cl− in cell culture perturbed collagen IV networks, disrupted matrix architecture, and repositioned basement membrane proteins. Phylogenetic evidence indicates this conformational switch is a fundamental mechanism of collagen IV network assembly throughout Metazoa. Using recombinant triple helical protomers, we prove that NC1 domains direct both protomer and network assembly and show in Drosophila that NC1 architecture is critical for incorporation into basement membranes. These discoveries provide an atomic-level understanding of the dynamic interactions between extracellular Cl− and collagen IV assembly outside cells, a critical step in the assembly and organization of basement membranes that enable tissue architecture and function. Moreover, this provides a mechanistic framework for understanding the molecular pathobiology of NC1 domains. PMID:27216258

Flaw-induced plastic-flow dynamics in bulk metallic glasses under tension

PubMed Central

Chen, S. H.; Yue, T. M.; Tsui, C. P.; Chan, K. C.

2016-01-01

Inheriting amorphous atomic structures without crystalline lattices, bulk metallic glasses (BMGs) are known to have superior mechanical properties, such as high strength approaching the ideal value, but are susceptible to catastrophic failures. Understanding the plastic-flow dynamics of BMGs is important for achieving stable plastic flow in order to avoid catastrophic failures, especially under tension, where almost all BMGs demonstrate limited plastic flow with catastrophic failure. Previous findings have shown that the plastic flow of BMGs displays critical dynamics under compression tests, however, the plastic-flow dynamics under tension are still unknown. Here we report that power-law critical dynamics can also be achieved in the plastic flow of tensile BMGs by introducing flaws. Differing from the plastic flow under compression, the flaw-induced plastic flow under tension shows an upward trend in the amplitudes of the load drops with time, resulting in a stable plastic-flow stage with a power-law distribution of the load drop. We found that the flaw-induced plastic flow resulted from the stress gradients around the notch roots, and the stable plastic-flow stage increased with the increase of the stress concentration factor ahead of the notch root. The findings are potentially useful for predicting and avoiding the catastrophic failures in tensile BMGs by tailoring the complex stress fields in practical structural-applications. PMID:27779221

Independent verification survey report for exposure units Z2-24, Z2-31, Z2-32, AND Z2-36 in zone 2 of the East Tennessee technology park Oak Ridge, Tennessee

DOE Office of Scientific and Technical Information (OSTI.GOV)

King, David A.

The U.S. Department of Energy (DOE) Oak Ridge Office of Environmental Management selected Oak Ridge Associated Universities (ORAU), through the Oak Ridge Institute for Science and Education (ORISE) contract, to perform independent verification (IV) at Zone 2 of the East Tennessee Technology Park (ETTP) in Oak Ridge, Tennessee. ORAU has concluded IV surveys, per the project-specific plan (PSP) (ORAU 2013a) covering exposure units (EUs) Z2-24, -31, -32, and -36. The objective of this effort was to verify the target EUs comply with requirements in the Zone 2 Record of Decision (ROD) (DOE 2005), as implemented by using the dynamic verificationmore » strategy presented in the dynamic work plan (DWP) (BJC 2007); and confirm commitments in the DWP were adequately implemented, as verified via IV surveys and soil sampling.« less

The First Static and Dynamic Analysis of 3-D Printed Sintered Ceramics for Body Armor Applications

DTIC Science & Technology

2016-09-01

evaluate sintered alumina tiles produced by 3-D printing methodology. This report examines the static and quasi -static parameters (including density...Figures iv List of Tables iv Acknowledgments v 1. Introduction 1 2. Processing and Experimental Procedures 1 3. Results and Discussion 7 4...6 Fig. 8 Experimental setup for recording fracture .............................................7 Fig. 9 Rod projectile

Taking a Population Census, Episode IV. Resource Material Development: Population Dynamics in Eighth Grade American History.

ERIC Educational Resources Information Center

Massialas, Byron G.; And Others

This is the fourth unit in a series that introduces population concepts into the eighth grade American history curriculum. (See SO 013 782 for an overview of the guide.) In Episode IV, the history topic is union under the Constitution. Objectives are to (1) help the student to examine the need for collecting information on the population during…

Deposition and fine particle production during dynamic flow in a dry powder inhaler: a CFD approach.

PubMed

Milenkovic, J; Alexopoulos, A H; Kiparissides, C

2014-01-30

In this work the dynamic flow as well as the particle motion and deposition in a commercial dry powder inhaler, DPI (i.e., Turbuhaler) is described using computational fluid dynamics, CFD. The dynamic flow model presented here is an extension of a steady flow model previously described in Milenkovic et al. (2013). The model integrates CFD simulations for dynamic flow, an Eulerian-fluid/Lagrangian-particle description of particle motion as well as a particle/wall interaction model providing the sticking efficiency of particles colliding with the DPI walls. The dynamic flow is imposed by a time varying outlet pressure and the particle injections into the DPI are assumed to occur instantaneously and follow a prescribed particle size distribution, PSD. The total particle deposition and the production of fine particles in the DPI are determined for different peak inspiratory flow rates, PIFR, flow increase rates, FIR, and particle injection times. The simulation results for particle deposition are found to agree well with available experimental data for different values of PIFR and FIR. The predicted values of fine particle fraction are in agreement with available experimental results when the mean size of the injected PSD is taken to depend on the PIFR. Copyright © 2013 Elsevier B.V. All rights reserved.

Fluid mechanics of dynamic stall. II - Prediction of full scale characteristics

NASA Technical Reports Server (NTRS)

Ericsson, L. E.; Reding, J. P.

1988-01-01

Analytical extrapolations are made from experimental subscale dynamics to predict full scale characteristics of dynamic stall. The method proceeds by establishing analytic relationships between dynamic and static aerodynamic characteristics induced by viscous flow effects. The method is then validated by predicting dynamic test results on the basis of corresponding static test data obtained at the same subscale flow conditions, and the effect of Reynolds number on the static aerodynamic characteristics are determined from subscale to full scale flow conditions.

HIF-1α signaling activation by post-ischemia treatment with astragaloside IV attenuates myocardial ischemia-reperfusion injury.

PubMed

Si, Jingwen; Wang, Ning; Wang, Huan; Xie, Juan; Yang, Jian; Yi, Hui; Shi, Zixuan; Ma, Jing; Wang, Wen; Yang, Lifang; Yu, Shiqiang; Li, Junchang

2014-01-01

In this study, we evaluated the effect of astragaloside IV (Ast IV) post-ischemia treatment on myocardial ischemia-reperfusion (IR) injury (IRI). We also examined whether hypoxia inducible factor-1α (HIF-1α) and its downstream gene-inducible nitric oxide (NO) synthase (iNOS) play roles in the cardioprotective effect of Ast IV. Cultured cardiomyocytes and perfused isolated rat hearts were exposed to Ast IV during reperfusion in the presence or absence of the HIF-1α inhibitor 2-methoxyestradiol (2-MeOE2). The post-ischemia treatment with Ast IV protected cardiomyocytes from the apoptosis and death induced by simulated IRI (SIRI). Additionally, in cardiomyocytes, 2-MeOE2 and HIF-1α siRNA treatment each not only abolished the anti-apoptotic effect of post-ischemia treatment with Ast IV but also reversed the upregulation of HIF-1α and iNOS expression. Furthermore, after treatment with Ast IV, post-ischemic cardiac functional recovery and lactate dehydrogenase (LDH) release in the coronary flow (CF) were improved, and the myocardial infarct size was decreased. Moreover, the number of apoptotic cells was reduced, and the upregulation of the anti-apoptotic protein Bcl2 and downregulation of the pro-apoptotic protein Caspase3 were reversed. 2-MeOE2 reversed these effects of Ast IV on IR-injured hearts. These results suggest that post-ischemia treatment with Ast IV can attenuate IRI by upregulating HIF-1α expression, which transmits a survival signal to the myocardium.

Integrating flood modelling in a hydrological catchment model: flow approximations and spatial resolution.

NASA Astrophysics Data System (ADS)

van den Bout, Bastian; Jetten, Victor

2017-04-01

Within hydrological models, flow approximations are commonly used to reduce computation time. The validity of these approximations is strongly determined by flow height, flow velocity, the spatial resolution of the model, and by the manner in which flow routing is implemented. The assumptions of these approximations can furthermore limit emergent behavior, and influence flow behavior under space-time scaling. In this presentation, the validity and performance of the kinematic, diffusive and dynamic flow approximations are investigated for use in a catchment-based flood model. Particularly, the validity during flood events and for varying spatial resolutions is investigated. The OpenLISEM hydrological model is extended to implement these flow approximations and channel flooding based on dynamic flow. The kinematic routing uses a predefined converging flow network, the diffusive and dynamic routing uses a 2D flow solution over a DEM. The channel flow in all cases is a 1D kinematic wave approximation. The flow approximations are used to recreate measured discharge in three catchments of different size in China, Spain and Italy, among which is the hydrograph of the 2003 flood event in the Fella river basin (Italy). Furthermore, spatial resolutions are varied for the flood simulation in order to investigate the influence of spatial resolution on these flow approximations. Results show that the kinematic, diffusive and dynamic flow approximation provide least to highest accuracy, respectively, in recreating measured temporal variation of the discharge. Kinematic flow, which is commonly used in hydrological modelling, substantially over-estimates hydrological connectivity in the simulations with a spatial resolution of below 30 meters. Since spatial resolutions of models have strongly increased over the past decades, usage of routed kinematic flow should be reconsidered. In the case of flood events, spatial modelling of kinematic flow substantially over-estimates hydrological connectivity and flow concentration, leading to significant errors. The combination of diffusive or dynamic overland flow and dynamic channel flooding provides high accuracy in recreating the 2003 Fella river flood event. Finally, flow approximations substantially influenced the predictive potential of the (flash) flood model.

Lubricant dynamics under sliding condition in disk drives

NASA Astrophysics Data System (ADS)

Wu, Lin

2006-07-01

In this paper, we develop a two-dimensional flow model for the lubricant flow dynamics under a sliding head in disk drives. Our two-dimensional model includes important physics such as viscous force, external air shearing stress, air bearing pressure, centrifugal force, disjoining pressure, and surface tension. Our analysis shows that the lubricant flow dynamics under the sliding condition is a fully two-dimensional phenomenon and the circumferential lubricant flow is strongly coupled to the radial flow. It is necessary to have a two-dimensional flow model that couples the circumferential and radial flows together and includes all important physics to achieve realistic predictions. Our results show that the external air shearing stress has a dominant effect on the lubricant flow dynamics. Both velocity slippage at wall and Poiseuille flow effects have to be considered in the evaluation of the air shearing stress under the head. The nonuniform air bearing pressure has a non-negligible effect on the lubricant film dynamics mostly through the Poiseuille flow effect on the air shearing stress but not from its direct pushing or sucking effect on the lubricant surface. Prediction of the formation of lubricant depletion tracks under a sliding head using the two-dimensional model agrees reasonably well with the existing experimental measurements.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burkholder, Michael B.; Litster, Shawn, E-mail: litster@andrew.cmu.edu

In this study, we analyze the stability of two-phase flow regimes and their transitions using chaotic and fractal statistics, and we report new measurements of dynamic two-phase pressure drop hysteresis that is related to flow regime stability and channel water content. Two-phase flow dynamics are relevant to a variety of real-world systems, and quantifying transient two-phase flow phenomena is important for efficient design. We recorded two-phase (air and water) pressure drops and flow images in a microchannel under both steady and transient conditions. Using Lyapunov exponents and Hurst exponents to characterize the steady-state pressure fluctuations, we develop a new, measurablemore » regime identification criteria based on the dynamic stability of the two-phase pressure signal. We also applied a new experimental technique by continuously cycling the air flow rate to study dynamic hysteresis in two-phase pressure drops, which is separate from steady-state hysteresis and can be used to understand two-phase flow development time scales. Using recorded images of the two-phase flow, we show that the capacitive dynamic hysteresis is related to channel water content and flow regime stability. The mixed-wettability microchannel and in-channel water introduction used in this study simulate a polymer electrolyte fuel cell cathode air flow channel.« less

A flexible and transparent graphene/ZnO nanorod hybrid structure fabricated by exfoliating a graphite substrate

NASA Astrophysics Data System (ADS)

Nam, Gwang-Hee; Baek, Seong-Ho; Cho, Chang-Hee; Park, Il-Kyu

2014-09-01

We demonstrate the fabrication of a graphene/ZnO nanorod (NR) hybrid structure by mechanical exfoliation of ZnO NRs grown on a graphite substrate. We confirmed the existence of graphene sheets on the hybrid structure by analyzing the Raman spectra and current-voltage (I-V) characteristics. The Raman spectra of the exfoliated graphene/ZnO NR hybrid structure show G and 2D band peaks that are shifted to lower wavenumbers, indicating that the exfoliated graphene layer exists under a significant amount of strain. The I-V characteristics of the graphene/ZnO NR hybrid structure show current flow through the graphene layer, while no current flow is observed on the ZnO NR/polydimethylsiloxane (PDMS) composite without graphene, thereby indicating that the few-layer graphene was successfully transferred onto the hybrid structure. A piezoelectric nanogenerator is demonstrated by using the fabricated graphene/ZnO NR hybrid structure. The nanogenerator exhibits stable output voltage up to 3.04 V with alternating current output characteristics.We demonstrate the fabrication of a graphene/ZnO nanorod (NR) hybrid structure by mechanical exfoliation of ZnO NRs grown on a graphite substrate. We confirmed the existence of graphene sheets on the hybrid structure by analyzing the Raman spectra and current-voltage (I-V) characteristics. The Raman spectra of the exfoliated graphene/ZnO NR hybrid structure show G and 2D band peaks that are shifted to lower wavenumbers, indicating that the exfoliated graphene layer exists under a significant amount of strain. The I-V characteristics of the graphene/ZnO NR hybrid structure show current flow through the graphene layer, while no current flow is observed on the ZnO NR/polydimethylsiloxane (PDMS) composite without graphene, thereby indicating that the few-layer graphene was successfully transferred onto the hybrid structure. A piezoelectric nanogenerator is demonstrated by using the fabricated graphene/ZnO NR hybrid structure. The nanogenerator exhibits stable output voltage up to 3.04 V with alternating current output characteristics. Electronic supplementary information (ESI) available. See DOI: 10.1039/c4nr02318h

[Pharmacological study of nicergoline. (III). Effects on cerebral and peripheral circulation in animals].

PubMed

Shintomi, K; Ogawa, Y; Yoshimoto, K; Narita, H

1986-05-01

Effects of nicergoline on the cerebral and peripheral circulation were compared with those of dihydroergotoxine (DHE) and papaverine (PAP) in anesthetized and/or immobilized cats. The i.a. injection of nicergoline (0.032 approximately 32 micrograms/kg), similarly to PAP, caused dose-dependent increases in intramaxillary artery (as the human intracarotid artery) blood flow (IMBF) and femoral artery blood flow, but the injection of DHE had no effect on these blood flows. The i.v. injection of nicergoline (32 approximately 128 micrograms/kg) caused a dose-dependent fall in blood pressure (BP) and a transient slight decrease in cerebral vascular resistance, but did not affect IMBF, regional cerebral blood flow (r-CBF), intracranial pressure (ICP) and heart rate (HR). The i.v. injection of DHE produced a slight fall in BP and a marked long-lasting decrease in HR, without affecting other parameters. The i.v. injection of PAP (4 mg/kg) induced marked increases in IMBF, r-CBF, ICP and HR and caused a transient fall followed by a marked elevation in BP. The p.o. administration of nicergoline (0.06 approximately 4 mg/kg) caused a dose-dependent fall in BP and selective inhibition of pressure response to adrenaline (ID50: 0.25 mg/kg). The administration of DHE produced marked inhibition of pressure responses to both adrenaline and noradrenaline, accompanied with a slight fall in BP. Furthermore, the administration of nicergoline (3 approximately 100 mg/kg) induced a dose-dependent fall in BP in SHR. These results suggest that the cerebral and peripheral circulatory effects of nicergoline may be due to direct vasodilating action and alpha-blocking action in the animals.

Nonlinear problems in flight dynamics

NASA Technical Reports Server (NTRS)

Chapman, G. T.; Tobak, M.

1984-01-01

A comprehensive framework is proposed for the description and analysis of nonlinear problems in flight dynamics. Emphasis is placed on the aerodynamic component as the major source of nonlinearities in the flight dynamic system. Four aerodynamic flows are examined to illustrate the richness and regularity of the flow structures and the nature of the flow structures and the nature of the resulting nonlinear aerodynamic forces and moments. A framework to facilitate the study of the aerodynamic system is proposed having parallel observational and mathematical components. The observational component, structure is described in the language of topology. Changes in flow structure are described via bifurcation theory. Chaos or turbulence is related to the analogous chaotic behavior of nonlinear dynamical systems characterized by the existence of strange attractors having fractal dimensionality. Scales of the flow are considered in the light of ideas from group theory. Several one and two degree of freedom dynamical systems with various mathematical models of the nonlinear aerodynamic forces and moments are examined to illustrate the resulting types of dynamical behavior. The mathematical ideas that proved useful in the description of fluid flows are shown to be similarly useful in the description of flight dynamic behavior.

The validity of flow approximations when simulating catchment-integrated flash floods

NASA Astrophysics Data System (ADS)

Bout, B.; Jetten, V. G.

2018-01-01

Within hydrological models, flow approximations are commonly used to reduce computation time. The validity of these approximations is strongly determined by flow height, flow velocity and the spatial resolution of the model. In this presentation, the validity and performance of the kinematic, diffusive and dynamic flow approximations are investigated for use in a catchment-based flood model. Particularly, the validity during flood events and for varying spatial resolutions is investigated. The OpenLISEM hydrological model is extended to implement both these flow approximations and channel flooding based on dynamic flow. The flow approximations are used to recreate measured discharge in three catchments, among which is the hydrograph of the 2003 flood event in the Fella river basin. Furthermore, spatial resolutions are varied for the flood simulation in order to investigate the influence of spatial resolution on these flow approximations. Results show that the kinematic, diffusive and dynamic flow approximation provide least to highest accuracy, respectively, in recreating measured discharge. Kinematic flow, which is commonly used in hydrological modelling, substantially over-estimates hydrological connectivity in the simulations with a spatial resolution of below 30 m. Since spatial resolutions of models have strongly increased over the past decades, usage of routed kinematic flow should be reconsidered. The combination of diffusive or dynamic overland flow and dynamic channel flooding provides high accuracy in recreating the 2003 Fella river flood event. Finally, in the case of flood events, spatial modelling of kinematic flow substantially over-estimates hydrological connectivity and flow concentration since pressure forces are removed, leading to significant errors.

Vector Flow Visualization of Urinary Flow Dynamics in a Bladder Outlet Obstruction Model.

PubMed

Ishii, Takuro; Yiu, Billy Y S; Yu, Alfred C H

2017-11-01

Voiding dysfunction that results from bladder outlet (BO) obstruction is known to alter significantly the dynamics of urine passage through the urinary tract. To non-invasively image this phenomenon on a time-resolved basis, we pursued the first application of a recently developed flow visualization technique called vector projectile imaging (VPI) that can track the spatiotemporal dynamics of flow vector fields at a frame rate of 10,000 fps (based on plane wave excitation and least-squares Doppler vector estimation principles). For this investigation, we designed a new anthropomorphic urethral tract phantom to reconstruct urinary flow dynamics under controlled conditions (300 mm H 2 O inlet pressure and atmospheric outlet pressure). Both a normal model and a diseased model with BO obstruction were developed for experimentation. VPI cine loops were derived from these urinary flow phantoms. Results show that VPI is capable of depicting differences in the flow dynamics of normal and diseased urinary tracts. In the case with BO obstruction, VPI depicted the presence of BO flow jet and vortices in the prostatic urethra. The corresponding spatial-maximum flow velocity magnitude was estimated to be 2.43 m/s, and it is significantly faster than that for the normal model (1.52 m/s) and is in line with values derived from computational fluid dynamics simulations. Overall, this investigation demonstrates the feasibility of using vector flow visualization techniques to non-invasively examine internal flow characteristics related to voiding dysfunction in the urethral tract. Copyright © 2017 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.

Vortex depinning as a nonequilibrium phase transition phenomenon: Scaling of current-voltage curves near the low and the high critical-current states in 2 H -Nb S2 single crystals

NASA Astrophysics Data System (ADS)

Bag, Biplab; Sivananda, Dibya J.; Mandal, Pabitra; Banerjee, S. S.; Sood, A. K.; Grover, A. K.

2018-04-01

The vortex depinning phenomenon in single crystals of 2 H -Nb S2 superconductors is used as a prototype for investigating properties of the nonequilibrium (NEQ) depinning phase transition. The 2 H -Nb S2 is a unique system as it exhibits two distinct depinning thresholds, viz., a lower critical current Icl and a higher one Ich. While Icl is related to depinning of a conventional, static (pinned) vortex state, the state with Ich is achieved via a negative differential resistance (NDR) transition where the velocity abruptly drops. Using a generalized finite-temperature scaling ansatz, we study the scaling of current (I)-voltage (V) curves measured across Icl and Ich. Our analysis shows that for I >Icl , the moving vortex state exhibits Arrhenius-like thermally activated flow behavior. This feature persists up to a current value where an inflexion in the IV curves is encountered. While past measurements have often reported similar inflexion, our analysis shows that the inflexion is a signature of a NEQ phase transformation from a thermally activated moving vortex phase to a free flowing phase. Beyond this inflection in IV, a large vortex velocity flow regime is encountered in the 2 H -Nb S2 system, wherein the Bardeen-Stephen flux flow limit is crossed. In this regime the NDR transition is encountered, leading to the high Ich state. The IV curves above Ich we show do not obey the generalized finite-temperature scaling ansatz (as obeyed near Icl). Instead, they scale according to the Fisher's scaling form [Fisher, Phys. Rev. B 31, 1396 (1985), 10.1103/PhysRevB.31.1396] where we show thermal fluctuations do not affect the vortex flow, unlike that found for depinning near Icl.

A Lagrangian subgrid-scale model with dynamic estimation of Lagrangian time scale for large eddy simulation of complex flows

NASA Astrophysics Data System (ADS)

Verma, Aman; Mahesh, Krishnan

2012-08-01

The dynamic Lagrangian averaging approach for the dynamic Smagorinsky model for large eddy simulation is extended to an unstructured grid framework and applied to complex flows. The Lagrangian time scale is dynamically computed from the solution and does not need any adjustable parameter. The time scale used in the standard Lagrangian model contains an adjustable parameter θ. The dynamic time scale is computed based on a "surrogate-correlation" of the Germano-identity error (GIE). Also, a simple material derivative relation is used to approximate GIE at different events along a pathline instead of Lagrangian tracking or multi-linear interpolation. Previously, the time scale for homogeneous flows was computed by averaging along directions of homogeneity. The present work proposes modifications for inhomogeneous flows. This development allows the Lagrangian averaged dynamic model to be applied to inhomogeneous flows without any adjustable parameter. The proposed model is applied to LES of turbulent channel flow on unstructured zonal grids at various Reynolds numbers. Improvement is observed when compared to other averaging procedures for the dynamic Smagorinsky model, especially at coarse resolutions. The model is also applied to flow over a cylinder at two Reynolds numbers and good agreement with previous computations and experiments is obtained. Noticeable improvement is obtained using the proposed model over the standard Lagrangian model. The improvement is attributed to a physically consistent Lagrangian time scale. The model also shows good performance when applied to flow past a marine propeller in an off-design condition; it regularizes the eddy viscosity and adjusts locally to the dominant flow features.

Polymer Fluid Dynamics.

ERIC Educational Resources Information Center

Bird, R. Byron

1980-01-01

Problems in polymer fluid dynamics are described, including development of constitutive equations, rheometry, kinetic theory, flow visualization, heat transfer studies, flows with phase change, two-phase flow, polymer unit operations, and drag reduction. (JN)

Effect of two mouthwashes on salivary ph.

PubMed

Belardinelli, Paola A; Morelatto, Rosana A; Benavidez, Tomás E; Baruzzi, Ana M; López de Blanc, Silvia A

2014-01-01

To analyze the effect of two mouthwashes on salivary pH and correlate it with age, buffer capacity and saliva flow rate in healthy volunteers, a crossover phase IV clinical study involving three age-based groups was designed. Two commercial mouthwashes (MW), Cool Mint ListerineR (MWa) and Periobacter R (MWb) were used. The unstimulated saliva of each individual was first characterized by measuring flow rate, pH, and buffer capacity. Salivary pH was evaluated before rinsing with a given MW, immediately after rinsing, 5 minutes later, and then every 10 min (at 15, 25, 35 min) until the baseline pH was recovered. Paired t-test, ANOVA with a randomized block design, and Pearson correlation tests were used. Averages were 0.63 mL/min, 7.06, and 0.87 for flow rate, pH, and buffer capacity, respectively. An immediate significant increase in salivary pH was observed after rinsing, reaching average values of 7.24 (MWb) and 7.30 (MWa), which declined to an almost stable value 15 minutes. The great increase in salivary pH, after MW use shows that saliva is a dynamic system, and that the organism is capable of responding to a stimulus with changes in its composition. It is thus evident that pH of the external agent alone is not a good indicator for its erosive potential because biological systems tend to neutralize it. The results of this study enhance the importance of in vivo measurements and reinforce the concept of the protective action of saliva.

Temporal and spatial evolution characteristics of gas-liquid two-phase flow pattern based on image texture spectrum descriptor

NASA Astrophysics Data System (ADS)

Zhou, Xi-Guo; Jin, Ning-De; Wang, Zhen-Ya; Zhang, Wen-Yin

2009-11-01

The dynamic image information of typical gas-liquid two-phase flow patterns in vertical upward pipe is captured by a highspeed dynamic camera. The texture spectrum descriptor is used to describe the texture characteristics of the processed images whose content is represented in the form of texture spectrum histogram, and four time-varying characteristic parameter indexes which represent image texture structure of different flow patterns are extracted. The study results show that the amplitude fluctuation of texture characteristic parameter indexes of bubble flow is lowest and shows very random complex dynamic behavior; the amplitude fluctuation of slug flow is higher and shows intermittent motion behavior between gas slug and liquid slug, and the amplitude fluctuation of churn flow is the highest and shows better periodicity; the amplitude fluctuation of bubble-slug flow is from low to high and oscillating frequence is higher than that of slug flow, and includes the features of both slug flow and bubble flow; the slug-churn flow loses the periodicity of slug flow and churn flow, and the amplitude fluctuation is high. The results indicate that the image texture characteristic parameter indexes of different flow pattern can reflect the flow characteristics of gas-liquid two-phase flow, which provides a new approach to understand the temporal and spatial evolution of flow pattern dynamics.

Can a simple dynamical system describe the interplay between drag and buoyancy in terrain-induced canopy flows?

DOE Office of Scientific and Technical Information (OSTI.GOV)

De Roo, Frederik; Banerjee, Tirtha

Under non-neutral stratification and in the presence of topography the dynamics of turbulent flow within a canopy is not yet completely understood. This has, among others, serious implications for the measurement of surface – atmosphere exchange by means of eddy-covariance: for example the measurement of carbon dioxide fluxes are strongly influenced if drainage flows occur during night, when the flow within the canopy decouples from the flow aloft. An improved physical understanding of the behavior of scalars under canopy turbulence in complex terrain is urgently needed. In the present work, we investigate the dynamics of turbulent flow within sloped canopies,more » focusing on the slope wind and potential temperature. We concentrate on the presence of oscillatory behavior in the flow variables in terms of switching of flow regimes by conducting linear stability analysis. We revisit and correct the simplified theory that exists in the literature, which is based on the interplay between the drag force and the buoyancy. We find that the simplified description of this dynamical system cannot exhibit the observed richness of the dynamics. To augment the simplified dynamical system’s analysis, we make use of large-eddy simulation of a three-dimensional hill covered by a homogeneous forest and analyze the phase synchronization behavior of the buoyancy and drag forces in the momentum budget to explore the turbulent dynamics in more detail.« less

Can a simple dynamical system describe the interplay between drag and buoyancy in terrain-induced canopy flows?

DOE PAGES

De Roo, Frederik; Banerjee, Tirtha

2018-02-23

Under non-neutral stratification and in the presence of topography the dynamics of turbulent flow within a canopy is not yet completely understood. This has, among others, serious implications for the measurement of surface – atmosphere exchange by means of eddy-covariance: for example the measurement of carbon dioxide fluxes are strongly influenced if drainage flows occur during night, when the flow within the canopy decouples from the flow aloft. An improved physical understanding of the behavior of scalars under canopy turbulence in complex terrain is urgently needed. In the present work, we investigate the dynamics of turbulent flow within sloped canopies,more » focusing on the slope wind and potential temperature. We concentrate on the presence of oscillatory behavior in the flow variables in terms of switching of flow regimes by conducting linear stability analysis. We revisit and correct the simplified theory that exists in the literature, which is based on the interplay between the drag force and the buoyancy. We find that the simplified description of this dynamical system cannot exhibit the observed richness of the dynamics. To augment the simplified dynamical system’s analysis, we make use of large-eddy simulation of a three-dimensional hill covered by a homogeneous forest and analyze the phase synchronization behavior of the buoyancy and drag forces in the momentum budget to explore the turbulent dynamics in more detail.« less

Identifying Hydrogeological Controls of Catchment Low-Flow Dynamics Using Physically Based Modelling

NASA Astrophysics Data System (ADS)

Cochand, F.; Carlier, C.; Staudinger, M.; Seibert, J.; Hunkeler, D.; Brunner, P.

2017-12-01

Identifying key catchment characteristics and processes which control the hydrological response under low-flow conditions is important to assess the catchments' vulnerability to dry periods. In the context of a Swiss Federal Office for the Environment (FOEN) project, the low-flow behaviours of two mountainous catchments were investigated. These neighboring catchments are characterized by the same meteorological conditions, but feature completely different river flow dynamics. The Roethenbach is characterized by high peak flows and low mean flows. Conversely, the Langete is characterized by relatively low peak flows and high mean flow rates. To understand the fundamentally different behaviour of the two catchments, a physically-based surface-subsurface flow HydroGeoSphere (HGS) model for each catchment was developed. The main advantage of a physically-based model is its ability to realistically reproduce processes which play a key role during low-flow periods such as surface-subsurface interactions or evapotranspiration. Both models were calibrated to reproduce measured groundwater heads and the surface flow dynamics. Subsequently, the calibrated models were used to explore the fundamental physics that control hydrological processes during low-flow periods. To achieve this, a comparative sensitivity analysis of model parameters of both catchments was carried out. Results show that the hydraulic conductivity of the bedrock (and weathered bedrock) controls the catchment water dynamics in both models. Conversely, the properties of other geological formations such as alluvial aquifer or soil layer hydraulic conductivity or porosity play a less important role. These results change significantly our perception of the streamflow catchment dynamics and more specifically the way to assess catchment vulnerability to dry period. This study suggests that by analysing catchment scale bedrock properties, the catchment dynamics and the vulnerability to dry period may be assessed.

Partitioning dynamics of unsaturated flows in fractured porous media: Laboratory studies and three-dimensional multi-scale smoothed particle hydrodynamics simulations of gravity-driven flow in fractures

NASA Astrophysics Data System (ADS)

Kordilla, J.; Bresinsky, L. T.; Shigorina, E.; Noffz, T.; Dentz, M.; Sauter, M.; Tartakovsky, A. M.

2017-12-01

Preferential flow dynamics in unsaturated fractures remain a challenging topic on various scales. On pore- and fracture-scales the highly erratic gravity-driven flow dynamics often provoke a strong deviation from classical volume-effective approaches. Against the common notion that flow in fractures (or macropores) can only occur under equilibrium conditions, i.e., if the surrounding porous matrix is fully saturated and capillary pressures are high enough to allow filling of the fracture void space, arrival times suggest the existence of rapid preferential flow along fractures, fracture networks, and fault zones, even if the matrix is not fully saturated. Modeling such flows requires efficient numerical techniques to cover various flow-relevant physics, such as surface tension, static and dynamic contact angles, free-surface (multi-phase) interface dynamics, and formation of singularities. Here we demonstrate the importance of such flow modes on the partitioning dynamics at simple fracture intersections, with a combination of laboratory experiments, analytical solutions and numerical simulations using our newly developed massively parallel smoothed particle hydrodynamics (SPH) code. Flow modes heavily influence the "bypass" behavior of water flowing along a fracture junction. Flows favoring the formation of droplets exhibit a much stronger bypass capacity compared to rivulet flows, where nearly the whole fluid mass is initially stored within the horizontal fracture. This behavior is demonstrated for a multi-inlet laboratory setup where the inlet-specific flow rate is chosen so that either a droplet or rivulet flow persists. The effect of fluid buffering within the horizontal fracture is presented in terms of dimensionless fracture inflow so that characteristic scaling regimes can be recovered. For both cases (rivulets and droplets), flow within the horizontal fracture transitions into a Washburn regime until a critical threshold is reached and the bypass efficiency increases. For rivulet flows, the initial filling of the horizontal fracture is described by classical plug flow. Meanwhile, for droplet flows, a size-dependent partitioning behavior is observed, and the filling of the fracture takes longer.

Dynamics of the blood flow in the curved artery with the rolling massage

NASA Astrophysics Data System (ADS)

Yi, H. H.; Wu, X. H.; Yao, Y. L.

2011-10-01

Arterial wall shear stress and flow velocity are important factors in the development of some arterial diseases. Here, we aim to investigate the dynamic effect of the rolling massage on the property of the blood flow in the curved artery. The distributions of flow velocity and shear stress for the blood flow are computed by the lattice Boltzmann method, and the dynamic factors under different rolling techniques are studied numerically. The study is helpful to understand the mechanism of the massage and develop the massage techniques.

And yet it moves! Involving transient flow conditions is the logical next step for WHPA analysis

NASA Astrophysics Data System (ADS)

Rodriguez-Pretelin, A.; Nowak, W.

2017-12-01

As the first line of defense among different safety measures, Wellhead Protection Areas (WHPAs) have been broadly used to protect drinking water wells against sources of pollution. In most cases, their implementation relies on simplifications, such as assuming homogeneous or zonated aquifer conditions or considering steady-state flow scenarios. Obviously, both assumptions inevitably invoke errors. However, while uncertainty due to aquifer heterogeneity has been extensively studied in the literature, the impact of transient flow conditions have received yet very little attention. For instance, WHPA maps in the offices of water supply companies are fixed maps derived from steady-state models although the actual catchment out there are transient. To mitigate high computational costs, we approximate transiency by means of a dynamic superposition of steady-state flow solutions. Then, we analyze four transient drivers that often appear on the seasonal scale: (I) regional groundwater flow direction, (II) strength of the regional hydraulic gradient, (III) natural recharge to the groundwater and (IV) pumping rate. The integration of transiency in WHPA analysis leads to time-frequency maps. They express for each location the temporal frequency of catchment membership. Furthermore, we account for the uncertainty due to incomplete knowledge on geological and transiency conditions, solved through Monte Carlo simulations. The main contribution of this study, is to show the need of enhancing groundwater well protection by considering transient flow considerations during WHPA analysis. To support and complement our statement, we demonstrate that 1) each transient driver imprints an individual spatial pattern in the required WHPA, ranking their influence through a global sensitivity analysis. 2) We compare the influence of transient conditions compared to geological uncertainty in terms of areal WHPA demand. 3) We show that considering geological uncertainty alone is insufficient in the presence of transient conditions. 4) We propose a practical decision rule for selecting a proper reliability level protection in the presence of both transiency and geological uncertainty.

Dynamic Characteristics of The DSI-Type Constant-Flow Valves

NASA Astrophysics Data System (ADS)

Kang, Yuan; Hu, Sheng-Yan; Chou, Hsien-Chin; Lee, Hsing-Han

Constant flow valves have been presented in industrial applications or academic studies, which compensate recess pressures of a hydrostatic bearing to resist load fluctuating. The flow rate of constant-flow valves can be constant in spite of the pressure changes in recesses, however the design parameters must be specified. This paper analyzes the dynamic responses of DSI-type constant-flow valves that is designed as double pistons on both ends of a spool with single feedback of working pressure and regulating restriction at inlet. In this study the static analysis presents the specific relationships among design parameters for constant flow rate and the dynamic analyses give the variations around the constant flow rate as the working pressure fluctuates.

Groundwater-Surface Water Interaction: A Case Study of Embankment Dam Safety Assessment in Sweden.

NASA Astrophysics Data System (ADS)

Ferdos, F.; Dargahi, B.

2015-12-01

Seepage, when excessive and unimpeded, can cause embankment dam failure. Such failures are often initiated by internal erosion and piping. Modelling these phenomena in embankment dams, accounting for the groundwater-surface water interactions, is crucial when performing dam safety assessments. The aim of this study was to evaluate the applicability of modelling seepage flows in multi-region dams using a finite element based multi-physics model. The model was applied to the Trängslet dam, the largest dam in Sweden. The objectives were to analyze the characteristics of both the flow and the surface-ground water interactions occurring in the dam, including: i) the saturated and unsaturated laminar flow regimes within the dam body, ii) the non-linear through-flow in the dam shoulders' coarse material, iii) the influence of the surface waves in the reservoir on the seepage flow by coupling the physics to a hydrodynamic interface, and iv) the influence of a conceptual "erosion tunnel" on the seepage flow and its interaction with the surface water flow by coupling the physics to a CFD interface. The focus of the study was on the influence of the transient water head boundary condition, surface waves and the internal erosion tunnel on the location of the phreatic line and the seepage flow rate. The simulated seepage flow of the dam in its original condition tallied with the monitoring measurements (40-70 l/s). The main feature found was the relatively high position of the phreatic line, which could compromise the stability of the dam. The combination of the seepage model with the reservoir hydrodynamics indicated a negligible influence of the surface waves on seepage flow. Results from the combination of the seepage model with fluid dynamics indicated that a conceptual "erosion tunnel" placed within the dam, even as high as in the unsaturated zone, significantly affects the phreatic line's position. This also causes the seepage flow to increase by several orders of magnitude, resulting in non-linear turbulent flow regimes in the downstream shoulder of the dam and, ultimately, dam failure. While the modelling was limited by a lack of reliable geometrical and geotechnical data, the results of the study do highlight the importance of including groundwater-surface water interactions in dam safety assessments.

Application of histogram analysis for the evaluation of vascular permeability in glioma by the K2 parameter obtained with the dynamic susceptibility contrast method: Comparisons with Ktrans obtained with the dynamic contrast enhance method and cerebral blood volume.

PubMed

Taoka, Toshiaki; Kawai, Hisashi; Nakane, Toshiki; Hori, Saeka; Ochi, Tomoko; Miyasaka, Toshiteru; Sakamoto, Masahiko; Kichikawa, Kimihiko; Naganawa, Shinji

2016-09-01

The "K2" value is a factor that represents the vascular permeability of tumors and can be calculated from datasets obtained with the dynamic susceptibility contrast (DSC) method. The purpose of the current study was to correlate K2 with Ktrans, which is a well-established permeability parameter obtained with the dynamic contrast enhance (DCE) method, and determine the usefulness of K2 for glioma grading with histogram analysis. The subjects were 22 glioma patients (Grade II: 5, III: 6, IV: 11) who underwent DSC studies, including eight patients in which both DSC and DCE studies were performed on separate days within 10days. We performed histogram analysis of regions of interest of the tumors and acquired 20th percentile values for leakage-corrected cerebral blood volume (rCBV20%ile), K2 (K220%ile), and for patients who underwent a DCE study, Ktrans (Ktrans20%ile). We evaluated the correlation between K220%ile and Ktrans20%ile and the statistical difference between rCBV20%ile and K220%ile. We found a statistically significant correlation between K220%ile and Ktrans20%ile (r=0.717, p<0.05). rCBV20%ile showed a significant difference between Grades II and III and between Grades II and IV, whereas K220%ile showed a statistically significant (p<0.05) difference between Grades II and IV and between Grades III and IV. The K2 value calculated from the DSC dataset, which can be obtained with a short acquisition time, showed a correlation with Ktrans obtained with the DCE method and may be useful for glioma grading when analyzed with histogram analysis. Copyright © 2016 Elsevier Inc. All rights reserved.

DYNAMIC MODELING STRATEGY FOR FLOW REGIME TRANSITION IN GAS-LIQUID TWO-PHASE FLOWS

DOE Office of Scientific and Technical Information (OSTI.GOV)

X. Wang; X. Sun; H. Zhao

In modeling gas-liquid two-phase flows, the concept of flow regime has been used to characterize the global interfacial structure of the flows. Nearly all constitutive relations that provide closures to the interfacial transfers in two-phase flow models, such as the two-fluid model, are often flow regime dependent. Currently, the determination of the flow regimes is primarily based on flow regime maps or transition criteria, which are developed for steady-state, fully-developed flows and widely applied in nuclear reactor system safety analysis codes, such as RELAP5. As two-phase flows are observed to be dynamic in nature (fully-developed two-phase flows generally do notmore » exist in real applications), it is of importance to model the flow regime transition dynamically for more accurate predictions of two-phase flows. The present work aims to develop a dynamic modeling strategy for determining flow regimes in gas-liquid two-phase flows through the introduction of interfacial area transport equations (IATEs) within the framework of a two-fluid model. The IATE is a transport equation that models the interfacial area concentration by considering the creation and destruction of the interfacial area, such as the fluid particle (bubble or liquid droplet) disintegration, boiling and evaporation; and fluid particle coalescence and condensation, respectively. For the flow regimes beyond bubbly flows, a two-group IATE has been proposed, in which bubbles are divided into two groups based on their size and shape (which are correlated), namely small bubbles and large bubbles. A preliminary approach to dynamically identifying the flow regimes is provided, in which discriminators are based on the predicted information, such as the void fraction and interfacial area concentration of small bubble and large bubble groups. This method is expected to be applied to computer codes to improve their predictive capabilities of gas-liquid two-phase flows, in particular for the applications in which flow regime transition occurs.« less

Simulation of electron transport across charged grain boundaries

NASA Astrophysics Data System (ADS)

Srikant, V.; Clarke, D. R.; Evans, P. V.

1996-09-01

The I-V (current density-electric field) characteristics of low-angle grain boundaries consisting of periodic arrays of charged dislocations are computed using a quasiclassical molecular dynamics approach. Below a critical value of the grain boundary misorientation, the computed I-V characteristics are linear whereas above they are nonlinear. The degree of nonlinearity and the voltage onset of nonlinearity are found to be dependent on the grain boundary misorientation.

In-vehicle signing functions of an in-vehicle information system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tufano, D.R.; Knee, H.E.; Spelt, P.F.

The definition of In-Vehicle Signing (IVS) functions was guided by the principles of traffic engineering as they apply to the design and placement of roadway signs. Because of the dynamic and active nature of computing, communications, and display technology, IVS can fulfill the signing principles of traffic engineering in ways that have been impossible with conventional signage. Current signing technology represents a series of compromises of these principles, especially the data and equations contributing to the calculation of required sight distance. A number of conditions relevant to sight distance are quite variable, e.g.: vehicle speed, visibility, weather, and driver reactionmore » time. However, conventional signing requires that there are fixed values of each variable for the determination of (e.g.) legibility distance. IVS, on the other hand, will be able to tailor the timing of sign presentation to the dynamically diverse variable values of all of these conditions. A clear, in-vehicle sign display, adaptive to ambient and driver conditions, will in fact obviate the entire issue of sign legibility. These capabilities, together with information filtering functions, will truly enhance the presentation of sign information to drivers. The development of IVS is a critical step in the development of an integrated In-Vehicle Information System (IVIS).« less

Numerical Simulation Of Flow Through An Artificial Heart

NASA Technical Reports Server (NTRS)

Rogers, Stuart; Kutler, Paul; Kwak, Dochan; Kiris, Centin

1991-01-01

Research in both artificial hearts and fluid dynamics benefits from computational studies. Algorithm that implements Navier-Stokes equations of flow extended to simulate flow of viscous, incompressible blood through articifial heart. Ability to compute details of such flow important for two reasons: internal flows with moving boundaries of academic interest in their own right, and many of deficiencies of artificial hearts attributable to dynamics of flow.

A smoothed particle hydrodynamics model for droplet and film flow on smooth and rough fracture surfaces

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kordilla, Jannes; Tartakovsky, Alexandre M.; Geyer, Tobias

2013-09-01

Flow on fracture surfaces has been identified by many authors as an important flow process in unsaturated fractured rock formations. Given the complexity of flow dynamics on such small scales, robust numerical methods have to be employed in order to capture the highly dynamic interfaces and flow intermittency. In this work we present microscale free-surface flow simulations using a three-dimensional multiphase Smoothed Particle Hydrodynamics (SPH) code. Pairwise solid-fluid and fluid-fluid interaction forces are used to control the wetting behavior and cover a wide range of static and transient contact angles as well as Reynolds numbers encountered in droplet flow onmore » rock surfaces. We validate our model via comparison with existing empirical and semi-analyical solutions for droplet flow. We use the model to investigate the occurence of adsorbed trailing films of droplets under various flow conditions and its importance for the flow dynamics when films and droplets coexist. We show that flow velocities are higher on prewetted surfaces covered by a thin film which is qualitatively attributed to the enhanced dynamic wetting and dewetting at the trailing and advancing contact line.« less

Frictional strength and heat flow of southern San Andreas Fault

NASA Astrophysics Data System (ADS)

Zhu, P. P.

2016-01-01

Frictional strength and heat flow of faults are two related subjects in geophysics and seismology. To date, the investigation on regional frictional strength and heat flow still stays at the stage of qualitative estimation. This paper is concentrated on the regional frictional strength and heat flow of the southern San Andreas Fault (SAF). Based on the in situ borehole measured stress data, using the method of 3D dynamic faulting analysis, we quantitatively determine the regional normal stress, shear stress, and friction coefficient at various seismogenic depths. These new data indicate that the southern SAF is a weak fault within the depth of 15 km. As depth increases, all the regional normal and shear stresses and friction coefficient increase. The former two increase faster than the latter. Regional shear stress increment per kilometer equals 5.75 ± 0.05 MPa/km for depth ≤15 km; regional normal stress increment per kilometer is equal to 25.3 ± 0.1 MPa/km for depth ≤15 km. As depth increases, regional friction coefficient increment per kilometer decreases rapidly from 0.08 to 0.01/km at depths less than ~3 km. As depth increases from ~3 to ~5 km, it is 0.01/km and then from ~5 to 15 km, and it is 0.002/km. Previously, frictional strength could be qualitatively determined by heat flow measurements. It is difficult to obtain the quantitative heat flow data for the SAF because the measured heat flow data exhibit large scatter. However, our quantitative results of frictional strength can be employed to investigate the heat flow in the southern SAF. We use a physical quantity P f to describe heat flow. It represents the dissipative friction heat power per unit area generated by the relative motion of two tectonic plates accommodated by off-fault deformation. P f is called "fault friction heat." On the basis of our determined frictional strength data, utilizing the method of 3D dynamic faulting analysis, we quantitatively determine the regional long-term fault friction heat at various seismogenic depths in the southern SAF. The new data show that as depth increases, regional friction stress increases within the depth of 15 km; its increment per kilometer equals 5.75 ± 0.05 MPa/km. As depth increases, regional long-term fault friction heat increases; its increment per kilometer is equal to 3.68 ± 0.03 mW/m2/km. The values of regional long-term fault friction heat provided by this study are always lower than those from heat flow measurements. The difference between them and the scatter existing in the measured heat flow data are mainly caused by the following processes: (i) heat convection, (ii) heat advection, (iii) stress accumulation, (iv) seismic bursts between short-term lull periods in a long-term period, and (v) influence of seismicity in short-term periods upon long-term slip rate and heat flow. Fault friction heat is a fundamental parameter in research on heat flow.

Degradation of nitrobenzene wastewater in an acidic environment by Ti(IV)/H2O2/O3 in a rotating packed bed.

PubMed

Yang, Peizhen; Luo, Shuai; Liu, Youzhi; Jiao, Weizhou

2018-06-23

The rotating packed bed (RPB) as a continuous flow reactor performs very well in degradation of nitrobenzene wastewater. In this study, acidic nitrobenzene wastewater was degraded using ozone (O 3 ) combined with hydrogen peroxide and titanium ions (Ti(IV)/H 2 O 2 /O 3 ) or using only H 2 O 2 /O 3 in a RPB. The degradation efficiency of nitrobenzene by Ti(IV)/H 2 O 2 /O 3 is roughly 16.84% higher than that by H 2 O 2 /O 3 , and it reaches as high as 94.64% in 30 min at a H 2 O 2 /O 3 molar ratio of 0.48. It is also found that the degradation efficiency of nitrobenzene is significantly affected by the high gravity factor, H 2 O 2 /O 3 molar ratio, and Ti(IV) concentration, and it reaches a maximum at a high gravity factor of 40, a Ti(IV) concentration of 0.50 mmol/L, a pH of 4.0, a H 2 O 2 /O 3 molar ratio of 0.48, a liquid flow rate of 120 L/h, and an initial nitrobenzene concentration of 1.22 mmol/L. Both direct ozonation and indirect ozonation are involved in the reaction of O 3 with organic pollutants. The indirect ozonation due to the addition of different amounts of tert-butanol (·OH scavenger) in the system accounts for 84.31% of the degradation efficiency of nitrobenzene, indicating that the nitrobenzene is dominantly oxidized by ·OH generated in the RPB-Ti(IV)/H 2 O 2 /O 3 process. Furthermore, the possible oxidative degradation mechanisms are also proposed to better understand the role of RPB in the removal of pollutants. Graphical abstract ᅟ.

Nonlinear vocal fold dynamics resulting from asymmetric fluid loading on a two-mass model of speech

NASA Astrophysics Data System (ADS)

Erath, Byron D.; Zañartu, Matías; Peterson, Sean D.; Plesniak, Michael W.

2011-09-01

Nonlinear vocal fold dynamics arising from asymmetric flow formations within the glottis are investigated using a two-mass model of speech with asymmetric vocal fold tensioning, representative of unilateral vocal fold paralysis. A refined theoretical boundary-layer flow solver is implemented to compute the intraglottal pressures, providing a more realistic description of the flow than the standard one-dimensional, inviscid Bernoulli flow solution. Vocal fold dynamics are investigated for subglottal pressures of 0.6 < ps < 1.5 kPa and tension asymmetries of 0.5 < Q < 0.8. As tension asymmetries become pronounced the asymmetric flow incites nonlinear behavior in the vocal fold dynamics at subglottal pressures that are associated with normal speech, behavior that is not captured with standard Bernoulli flow solvers. Regions of bifurcation, coexistence of solutions, and chaos are identified.

Spatio-temporal organization of dynamics in a two-dimensional periodically driven vortex flow: A Lagrangian flow network perspective.

PubMed

Lindner, Michael; Donner, Reik V

2017-03-01

We study the Lagrangian dynamics of passive tracers in a simple model of a driven two-dimensional vortex resembling real-world geophysical flow patterns. Using a discrete approximation of the system's transfer operator, we construct a directed network that describes the exchange of mass between distinct regions of the flow domain. By studying different measures characterizing flow network connectivity at different time-scales, we are able to identify the location of dynamically invariant structures and regions of maximum dispersion. Specifically, our approach allows us to delimit co-existing flow regimes with different dynamics. To validate our findings, we compare several network characteristics to the well-established finite-time Lyapunov exponents and apply a receiver operating characteristic analysis to identify network measures that are particularly useful for unveiling the skeleton of Lagrangian chaos.

Thermal Stratification Analysis for Sodium Fast Reactors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schneider, James; Anderson, Mark; Baglietto, Emilio

The sodium fast reactor (SFR) is the most mature reactor concept of all the generation-IV nuclear systems and is a promising reactor design that is currently under development by several organizations. The majority of sodium fast reactor designs utilize a pool type arrangement which incorporates the primary coolant pumps and intermediate heat exchangers within the sodium pool. These components typically protrude into the pool thus reducing the risk and severity of a loss of coolant accidents. To further ensure safe operation under even the most severe transients a more comprehensive understanding of key thermal hydraulic phenomena in this pool ismore » desired. One of the key technology gaps identified for SFR safety is determining the extent and the effects of thermal stratification developing in the pool during postulated accident scenarios such as a protected or unprotected loss of flow incident. In an effort to address these issues, detailed flow models of transient stratification in the pool during an accident can be developed. However, to develop the calculation models, and ensure they can reproduce the underlying physics, highly spatially resolved data is needed. This data can be used in conjunction with advanced computational fluid dynamic calculations to aid in the development of simple reduced dimensional models for systems codes such as SAM and SAS4A/SASSYS-1.« less

Dynamical Languages

NASA Astrophysics Data System (ADS)

Xie, Huimin

The following sections are included: * Definition of Dynamical Languages * Distinct Excluded Blocks * Definition and Properties * L and L″ in Chomsky Hierarchy * A Natural Equivalence Relation * Symbolic Flows * Symbolic Flows and Dynamical Languages * Subshifts of Finite Type * Sofic Systems * Graphs and Dynamical Languages * Graphs and Shannon-Graphs * Transitive Languages * Topological Entropy

Vorticity Dynamics in Single and Multiple Swirling Reacting Jets

NASA Astrophysics Data System (ADS)

Smith, Travis; Aguilar, Michael; Emerson, Benjamin; Noble, David; Lieuwen, Tim

2015-11-01

This presentation describes an analysis of the unsteady flow structures in two multinozzle swirling jet configurations. This work is motivated by the problem of combustion instabilities in premixed flames, a major concern in the development of modern low NOx combustors. The objective is to compare the unsteady flow structures in these two configurations for two separate geometries and determine how certain parameters, primarily distance between jets, influence the flow dynamics. The analysis aims to differentiate between the flow dynamics of single nozzle and triple nozzle configurations. This study looks at how the vorticity in the shear layers of one reacting swirling jet can affect the dynamics of a nearby similar jet. The distance between the swirling jets is found to have an effect on the flow field in determining where swirling jets merge and on the dynamics upstream of the merging location. Graduate Student, School of Aerospace Engineering, Georgia Institute of Technology, Atlanta, GA.

Transient flow conditions change how we should think about WHPA delineation: a joint frequency and probability analysis

NASA Astrophysics Data System (ADS)

Rodriguez Pretelin (1), Abelardo; Nowak (1), Wolfgang

2017-04-01

Well head protection areas (WHPAs) are frequently used as safety measures for drinking water wells, preventing them from being polluted by restricting land use activities in their proximities. Two sources of uncertainty are involved during delineation: 1) uncertainty in aquifer parameters and 2) time-varying groundwater flow scenarios and their own inherent uncertainties. The former has been studied by Enzenhoefer et al (2012 [1] and 2014 [2]) as probabilistic risk version of WHPA delineation. The latter is frequently neglected and replaced by steady-state assumptions; thereby ignoring time-variant flow conditions triggered either by anthropogenic causes or climatic conditions. In this study we analyze the influence of transient flow considerations in WHPA delineation, following annual seasonality behavior; with transiency represented by four transient conditions: (I) regional groundwater flow direction, (II) strength of the regional hydraulic gradient, (III) natural recharge to the groundwater and (IV) pumping rate. Addressing WHPA delineation in transient flow scenarios is computationally expensive. Thus, we develop an efficient method using a dynamic superposition of steady-state flow solutions coupled with a reversed formulation of advective-dispersive transport based on a Lagrangian particle tracking with continuous injection. This analysis results in a time-frequency map of pixel-wise membership to the well catchment. Additional to transient flow conditions, we recognize two sources of uncertainty, inexact knowledge of transient drivers and parameters. The uncertainties are accommodated through Monte Carlo simulation. With the help of a global sensitivity analysis, we investigate the impact of transiency in WHPA solutions. In particular, we evaluate: (1) Among all considered transients, which ones are the most influential. (2) How influential in WHPA delineation is the transience-related uncertainty compared to aquifer parameter uncertainty. Literature [1] R. Enzenhoefer, W. Nowak, and R. Helmig. Probabilistic exposure risk assessment with advective-dispersive well vulnerability criteria. Advances in Water Resources, 36:121-132, 2012. [2] R. Enzenhoefer, T. Bunk, and W. Nowak. Nine steps to risk-informed wellhead protection and management: a case study. Ground water, 52:161-174, 2014.

Axisymmetric flows from fluid injection into a confined porous medium

NASA Astrophysics Data System (ADS)

Guo, Bo; Zheng, Zhong; Celia, Michael A.; Stone, Howard A.

2016-02-01

We study the axisymmetric flows generated from fluid injection into a horizontal confined porous medium that is originally saturated with another fluid of different density and viscosity. Neglecting the effects of surface tension and fluid mixing, we use the lubrication approximation to obtain a nonlinear advection-diffusion equation that describes the time evolution of the sharp fluid-fluid interface. The flow behaviors are controlled by two dimensionless groups: M, the viscosity ratio of displaced fluid relative to injected fluid, and Γ, which measures the relative importance of buoyancy and fluid injection. For this axisymmetric geometry, the similarity solution involving R2/T (where R is the dimensionless radial coordinate and T is the dimensionless time) is an exact solution to the nonlinear governing equation for all times. Four analytical expressions are identified as asymptotic approximations (two of which are new solutions): (i) injection-driven flow with the injected fluid being more viscous than the displaced fluid (Γ ≪ 1 and M < 1) where we identify a self-similar solution that indicates a parabolic interface shape; (ii) injection-driven flow with injected and displaced fluids of equal viscosity (Γ ≪ 1 and M = 1), where we find a self-similar solution that predicts a distinct parabolic interface shape; (iii) injection-driven flow with a less viscous injected fluid (Γ ≪ 1 and M > 1) for which there is a rarefaction wave solution, assuming that the Saffman-Taylor instability does not occur at the reservoir scale; and (iv) buoyancy-driven flow (Γ ≫ 1) for which there is a well-known self-similar solution corresponding to gravity currents in an unconfined porous medium [S. Lyle et al. "Axisymmetric gravity currents in a porous medium," J. Fluid Mech. 543, 293-302 (2005)]. The various axisymmetric flows are summarized in a Γ-M regime diagram with five distinct dynamic behaviors including the four asymptotic regimes and an intermediate regime. The implications of the regime diagram are discussed using practical engineering projects of geological CO2 sequestration, enhanced oil recovery, and underground waste disposal.

NASA/MSFC's Calculation for Test Case 1a of ATAC-FSDC Workshop on After-body and Nozzle Flows

NASA Technical Reports Server (NTRS)

Ruf, Joseph H.

2006-01-01

Mr. Ruf of NASA/MSFC executed the CHEM computational fluid dynamics (CFD) code to provide a prediction of the test case 1 a for the ATAC-FSDC Workshop on After-body and Nozzle Flows. CHEM is used extensively at MSFC for a wide variety of fluid dynamic problems. These problems include; injector element flows, nozzle flows, feed line flows, turbomachinery flows, solid rocket motor internal flows, plume vehicle flow interactions, etc.

Siphon flows in isolated magnetic flux tubes. IV - Critical flows with standing tube shocks

NASA Technical Reports Server (NTRS)

Thomas, John H.; Montesinos, Benjamin

1991-01-01

Critical siphon flows in arched, isolated magnetic flux tubes are studied within the thin flux tube approximation, with a view toward applications to intense magnetic flux concentrations in the solar photosphere. The results of calculations of the strength and position of the standing tube shock in the supercritical downstream branch of a critical siphon flow are presented, as are calculations of the flow variables all along the flux tube and the equilibrium path of the flux tube in the surrounding atmosphere. It is suggested that arched magnetic flux tubes, with magnetic field strength increased by a siphon flow, may be associated with some of the intense, discrete magnetic elements observed in the solar photosphere.

LSPRAY-IV: A Lagrangian Spray Module

NASA Technical Reports Server (NTRS)

Raju, M. S.

2012-01-01

LSPRAY-IV is a Lagrangian spray solver developed for application with parallel computing and unstructured grids. It is designed to be massively parallel and could easily be coupled with any existing gas-phase flow and/or Monte Carlo Probability Density Function (PDF) solvers. The solver accommodates the use of an unstructured mesh with mixed elements of either triangular, quadrilateral, and/or tetrahedral type for the gas flow grid representation. It is mainly designed to predict the flow, thermal and transport properties of a rapidly vaporizing spray. Some important research areas covered as a part of the code development are: (1) the extension of combined CFD/scalar-Monte- Carlo-PDF method to spray modeling, (2) the multi-component liquid spray modeling, and (3) the assessment of various atomization models used in spray calculations. The current version contains the extension to the modeling of superheated sprays. The manual provides the user with an understanding of various models involved in the spray formulation, its code structure and solution algorithm, and various other issues related to parallelization and its coupling with other solvers.

Revised FORTRAN program for calculating velocities and streamlines on the hub-shroud midchannel stream surface of an axial-, radial-, or mixed-flow turbomachine or annular duct. 2: Programmer's manual

NASA Technical Reports Server (NTRS)

Katsanis, T.; Mcnally, W. D.

1977-01-01

A FORTRAN IV computer program has been developed that obtains a detailed subsonic or shock free transonic flow solution on the hub-shroud midchannel stream surface of a turbomachine. The blade row may be fixed or rotating, and the blades may be twisted and leaned. Flow may be axial, mixed, or radial. Upstream and downstream flow variables may vary from hub to shroud, and provisions are made to correct for loss of stagnation pressure. The results include velocities, streamlines, and flow angles on the stream surface and approximate blade surface velocities.

Response of hyporheic zones to transient forcing

NASA Astrophysics Data System (ADS)

Singh, T.; Wu, L.; Gomez-Velez, J. D.; Krause, S.; Hannah, D. M.; Lewandowski, J.; Nuetzmann, G.

2017-12-01

Exchange of water, solutes, and energy between river channels and hyporheic zones (HZs) modulates biogeochemical cycling, regulates stream temperature and impacts ecological structure and function. Numerical modelling of HZ processes is required as field observations are challenging for transient flow. To gain a deeper mechanistic understanding of the effects of transient discharge on hyporheic exchange, we performed a systematic analysis using numerical experiments. In this case, we vary (i) the characteristics of time-varying flood events; (ii) river bedform geometry; (iii) river hydraulic geometry; and (iv) the magnitude and direction of groundwater fluxes (neutral, gaining and losing conditions). We conceptualize the stream bed as a two-dimensional system. Whereby the flow is driven by a dynamically changing head distribution at the water-sediment interface and is modulated by steady groundwater flow. Our model estimates both net values for a single bedform and spatial distributions of (i) the flow field; (ii) mean residence times; and (iii) the concentration of a conservative tracer. A detailed sensitivity analysis was performed by changing channel slope, flood characteristics, groundwater upwelling/downwelling fluxes and biogeochemical time-scales in different bedforms such as ripples, dunes and alternating bars. Results show that change of parameters can have a substantial impact on exchange fluxes which can lead to the expansion, contraction, emergence and/or dissipation of HZs . Our results also reveal that groundwater fluxes have different impacts on HZs during flood events, depending on the channel slope and bedform topography. It is found that topographies with smaller aspect ratios and shallower slopes are more affected by groundwater upwelling/downwelling fluxes during flood events. The analysis of biogeochemical transformations shows that discharge events can potentially affects the efficiencies of nitrate removal. Taking into consideration multiple morphological characteristics along with hydrological controls are important to improve model conceptualizations at the reach and watershed scale.

Simulating Blade-Strike on Fish passing through Marine Hydrokinetic Turbines

DOE Office of Scientific and Technical Information (OSTI.GOV)

Romero Gomez, Pedro DJ; Richmond, Marshall C.

2014-06-16

The study reported here evaluated the occurrence, frequency, and intensity of blade strike of fish on an axial-flow marine hydrokinetic turbine by using two modeling approaches: a conventional kinematic formulation and a proposed Lagrangian particle- based scheme. The kinematic model included simplifying assumptions of fish trajectories such as distribution and velocity. The proposed method overcame the need for such simplifications by integrating the following components into a computational fluid dynamics (CFD) model: (i) advanced eddy-resolving flow simulation, (ii) generation of ambient turbulence based on field data, (iii) moving turbine blades in highly transient flows, and (iv) Lagrangian particles to mimicmore » the potential fish pathways. The test conditions to evaluate the blade-strike probability and fish survival rate were: (i) the turbulent environment, (ii) the fish size, and (iii) the approaching flow velocity. The proposed method offered the ability to produce potential fish trajectories and their interaction with the rotating turbine. Depending upon the scenario, the percentile of particles that registered a collision event ranged from 6% to 19% of the released sample size. Next, by using a set of experimental correlations of the exposure-response of living fish colliding with moving blades, the simulated collision data were used as input variables to estimate the survival rate of fish passing through the operating turbine. The resulting survival rates were greater than 96% in all scenarios, which is comparable to or better than known survival rates for conventional hydropower turbines. The figures of strike probability and mortality rate were amplified by the kinematic model. The proposed method offered the advantage of expanding the evaluation of other mechanisms of stress and injury on fish derived from hydrokinetic turbines and related devices.« less

Response of the solar atmosphere to a simple flare burst: UV emission from the flare transition layer.

NASA Astrophysics Data System (ADS)

Shmeleva, O. P.

The flare transition layer exists as a relatively steady formation even during impulsive heating. It is maintained by a heat flow from the high-temperature plasma, where the major part of the electron beam energy is absorbed. The lifetime of this plasma is much greater than the impulsive heating time. Intensities of resonance UV lines are calculated using both the model of impulsive nonthermal heating by energetic electrons and the model of continuous thermal heating. The calculated line intensity is almost constant during a long time. The line Doppler shifts predicted by the former model match observations. This suggests that the model represents sufficiently well the actual dynamics of the flare plasma. The flare transition layer is a thin formation, its thickness being Δξ = 1021m-2. It is therefore described adequately within the p = const approximation though the picture of hydrodynamic response of the solar atmosphere to the impulsive heating by energy flows is rather complicated and nonsteady, of course. The intensities of the C IV λλ154.8, 155.1 nm and O VI λλ103.2, 103.8 nm lines are calculated within the scope of the model of continuous thermal heating, in which the conductive heating of the flare transition layer is balanced by radiative cooling. The line intensities are proportional to the pressure in the layer, which permits the pressure to be found from the observed line intensities. The analysis reveals that both heating models adequately represent the actual structure and dynamics of plasma in a flare. In the flare transition layer, the classical heat conduction always does work.

A Uranium Bioremediation Reactive Transport Benchmark

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yabusaki, Steven B.; Sengor, Sevinc; Fang, Yilin

A reactive transport benchmark problem set has been developed based on in situ uranium bio-immobilization experiments that have been performed at a former uranium mill tailings site in Rifle, Colorado, USA. Acetate-amended groundwater stimulates indigenous microorganisms to catalyze the reduction of U(VI) to a sparingly soluble U(IV) mineral. The interplay between the flow, acetate loading periods and rates, microbially-mediated and geochemical reactions leads to dynamic behavior in metal- and sulfate-reducing bacteria, pH, alkalinity, and reactive mineral surfaces. The benchmark is based on an 8.5 m long one-dimensional model domain with constant saturated flow and uniform porosity. The 159-day simulation introducesmore » acetate and bromide through the upgradient boundary in 14-day and 85-day pulses separated by a 10 day interruption. Acetate loading is tripled during the second pulse, which is followed by a 50 day recovery period. Terminal electron accepting processes for goethite, phyllosilicate Fe(III), U(VI), and sulfate are modeled using Monod-type rate laws. Major ion geochemistry modeled includes mineral reactions, as well as aqueous and surface complexation reactions for UO2++, Fe++, and H+. In addition to the dynamics imparted by the transport of the acetate pulses, U(VI) behavior involves the interplay between bioreduction, which is dependent on acetate availability, and speciation-controlled surface complexation, which is dependent on pH, alkalinity and available surface complexation sites. The general difficulty of this benchmark is the large number of reactions (74), multiple rate law formulations, a multisite uranium surface complexation model, and the strong interdependency and sensitivity of the reaction processes. Results are presented for three simulators: HYDROGEOCHEM, PHT3D, and PHREEQC.« less

Superlattice Effects in Graphite Intercalation Compounds.

DTIC Science & Technology

1986-04-15

away from ;le[ Isy.st,.mns (r lin( nl :; atars ) and look for nonlinear dynamical effects -. m,,5,: U~ i,: ,1 : s y’t, rns, a3iioh m i Josephson...Intercalation Coaanm, Chemistry Dept., Northeast(.rn,, February 25, 1935. ( iv) "Giant Magnetic Interaction and Domain Dynamics in Twe -. "Dimensions," hoston

Dynamics of polymers in elongational flow studied by the neutron spin-echo technique

NASA Astrophysics Data System (ADS)

Rheinstädter, Maikel C.; Sattler, Rainer; Häußler, Wolfgang; Wagner, Christian

2010-09-01

The nanoscale fluctuation dynamics of semidilute high molecular weight polymer solutions of polyethylenoxide (PEO) in D 2O under non-equilibrium flow conditions were studied by the neutron spin-echo technique. The sample cell was in contraction flow geometry and provided a pressure driven flow with a high elongational component that stretched the polymers most efficiently. Neutron scattering experiments in dilute polymer solutions are challenging because of the low polymer concentration and corresponding small quasi-elastic signals. A relaxation process with relaxation times of about 10 ps was observed, which shows anisotropic dynamics with applied flow.

Information flow dynamics in the brain

NASA Astrophysics Data System (ADS)

Rabinovich, Mikhail I.; Afraimovich, Valentin S.; Bick, Christian; Varona, Pablo

2012-03-01

Timing and dynamics of information in the brain is a hot field in modern neuroscience. The analysis of the temporal evolution of brain information is crucially important for the understanding of higher cognitive mechanisms in normal and pathological states. From the perspective of information dynamics, in this review we discuss working memory capacity, language dynamics, goal-dependent behavior programming and other functions of brain activity. In contrast with the classical description of information theory, which is mostly algebraic, brain flow information dynamics deals with problems such as the stability/instability of information flows, their quality, the timing of sequential processing, the top-down cognitive control of perceptual information, and information creation. In this framework, different types of information flow instabilities correspond to different cognitive disorders. On the other hand, the robustness of cognitive activity is related to the control of the information flow stability. We discuss these problems using both experimental and theoretical approaches, and we argue that brain activity is better understood considering information flows in the phase space of the corresponding dynamical model. In particular, we show how theory helps to understand intriguing experimental results in this matter, and how recent knowledge inspires new theoretical formalisms that can be tested with modern experimental techniques.

Single polymer dynamics under large amplitude oscillatory extension

NASA Astrophysics Data System (ADS)

Zhou, Yuecheng; Schroeder, Charles M.

2016-09-01

Understanding the conformational dynamics of polymers in time-dependent flows is of key importance for controlling materials properties during processing. Despite this importance, however, it has been challenging to study polymer dynamics in controlled time-dependent or oscillatory extensional flows. In this work, we study the dynamics of single polymers in large-amplitude oscillatory extension (LAOE) using a combination of experiments and Brownian dynamics (BD) simulations. Two-dimensional LAOE flow is generated using a feedback-controlled stagnation point device known as the Stokes trap, thereby generating an oscillatory planar extensional flow with alternating principal axes of extension and compression. Our results show that polymers experience periodic cycles of compression, reorientation, and extension in LAOE, and dynamics are generally governed by a dimensionless flow strength (Weissenberg number Wi) and dimensionless frequency (Deborah number De). Single molecule experiments are compared to BD simulations with and without intramolecular hydrodynamic interactions (HI) and excluded volume (EV) interactions, and good agreement is obtained across a range of parameters. Moreover, transient bulk stress in LAOE is determined from simulations using the Kramers relation, which reveals interesting and unique rheological signatures for this time-dependent flow. We further construct a series of single polymer stretch-flow rate curves (defined as single molecule Lissajous curves) as a function of Wi and De, and we observe qualitatively different dynamic signatures (butterfly, bow tie, arch, and line shapes) across the two-dimensional Pipkin space defined by Wi and De. Finally, polymer dynamics spanning from the linear to nonlinear response regimes are interpreted in the context of accumulated fluid strain in LAOE.

Mass and energy supply of a cool coronal loop near its apex

NASA Astrophysics Data System (ADS)

Yan, Limei; Peter, Hardi; He, Jiansen; Xia, Lidong; Wang, Linghua

2018-03-01

Context. Different models for the heating of solar corona assume or predict different locations of the energy input: concentrated at the footpoints, at the apex, or uniformly distributed. The brightening of a loop could be due to the increase in electron density ne, the temperature T, or a mixture of both. Aim. We investigate possible reasons for the brightening of a cool loop at transition region temperatures through imaging and spectral observation. Methods: We observed a loop with the Interface Region Imaging Spectrograph (IRIS) and used the slit-jaw images together with spectra taken at a fixed slit position to study the evolution of plasma properties in and below the loop. We used spectra of Si IV, which forms at around 80 000 K in equilibrium, to identify plasma motions and derive electron densities from the ratio of inter-combination lines of O IV. Additional observations from the Solar Dynamics Observatory (SDO) were employed to study the response at coronal temperatures (Atmospheric Imaging Assembly, AIA) and to investigate the surface magnetic field below the loop (Helioseismic and Magnetic Imager, HMI). Results: The loop first appears at transition region temperatures and later also at coronal temperatures, indicating a heating of the plasma in the loop. The appearance of hot plasma in the loop coincides with a possible accelerating upflow seen in Si IV, with the Doppler velocity shifting continuously from -70 km s-1 to -265 km s-1. The 3D magnetic field lines extrapolated from the HMI magnetogram indicate possible magnetic reconnection between small-scale magnetic flux tubes below or near the loop apex. At the same time, an additional intensity enhancement near the loop apex is visible in the IRIS slit-jaw images at 1400 Å. These observations suggest that the loop is probably heated by the interaction between the loop and the upflows, which are accelerated by the magnetic reconnection between small-scale magnetic flux tubes at lower altitudes. Before and after the possible heating phase, the intensity changes in the optically thin (Si IV) and optical thick line (C II) are mainly contributed by the density variation without significant heating. Conclusions: We therefore provide evidence for the heating of an envelope loop that is affected by accelerating upflows, which are probably launched by magnetic reconnection between small-scale magnetic flux tubes underneath the envelope loop. This study emphasizes that in the complex upper atmosphere of the Sun, the dynamics of the 3D coupled magnetic field and flow field plays a key role in thermalizing 1D structures such as coronal loops. An animation associated to Fig. 1 is available at http://https://www.aanda.org

Stability analysis for capillary channel flow: 1d and 3d computations

NASA Astrophysics Data System (ADS)

Grah, Aleksander; Klatte, Jörg; Dreyer, Michael E.

The subject of the presentation are numerical studies on capillary channel flow, based on results of the sounding rocket TEXUS experiments. The flow through a capillary channel is established by a gear pump at the outlet. The channel, consists of two parallel glass plates with a width of 25 mm, a gap of 10 mm and a length of 12 mm. The meniscus of a compensation tube maintains a constant system pressure. Steady and dynamic pressure effects in the system force the surfaces to bend inwards. A maximum flow rate is achieved when the free surface collapses and gas ingestion occurs at the outlet. This critical flow rate depends on the channel geometry, the flow regime and the liquid properties. The aim of the experiments is the determination of the free surface shape and to find the maximum flow rate. In order to study the unsteady liquid loop behavior, a dimensionless one-dimensional model and a corresponding three-dimensional model were developed. The one-dimensional model is based on the unsteady Bernoulli equation, the unsteady continuity equation and geometrical conditions for the surface curvature and the flow cross-section. The experimental and evaluated contour data show good agreement for a sequence of transient flow rate perturbations. In the case of steady flow at maximum flow rate, when the "choking" effect occurs, the surfaces collapse and cause gas ingestion into the channel. This effect is related to the Speed Index. At the critical flow rate the Speed Index reaches the value 1, in analogy to the Mach Number. Unsteady choking does not necessarily cause surface collapse. We show, that temporarily Speed Index values exceeding One may be achieved for a perfectly stable supercritical dynamic flow. As a supercritical criterion for the dynamic free surface stability we define a Dynamic Index considering the local capillary pressure and the convective pressure, which is a function of the local velocity. The Dynamic Index is below One for stable flow while D = 1 indicates surface collapse. This studies lead to a stability diagram, which defines the limits of flow dynamics and the maximum unsteady flow rate.

The "focus on aneurysm" principle: Classification and surgical principles of management of concurrent arterial aneurysm with arteriovenous malformation causing intracranial hemorrhage.

PubMed

Jha, Vikas; Behari, Sanjay; Jaiswal, Awadhesh K; Bhaisora, Kamlesh Singh; Shende, Yogesh P; Phadke, Rajendra V

2016-01-01

Concurrent arterial aneurysms (AAs) occurring in 2.7-16.7% patients harboring an arteriovenous malformation (AVM) aggravate the risk of intracranial hemorrhage. We evaluate the variations of aneurysms simultaneously coexisting with AVMs. A classification-based management strategy and an abbreviated nomenclature that describes their radiological features is also proposed. Tertiary care academic institute. Test of significance applied to determine the factors causing rebleeding in the groups of patients with concurrent AVM and aneurysm and those with only AVMs. Sixteen patients (5 with subarachnoid hemorrhage and 11 with intracerebral/intraventricular hemorrhage; 10 with low flow [LF] and 6 with high flow [HF] AVMs) underwent radiological assessment of Spetzler Martin (SM) grading and flow status of AA + AVM. Their modified Rankin's score (mRS) at admission was compared with their follow-up (F/U) score. Pre-operative mRS was 0 in 5, 2 in 6, 3 in 1, 4 in 3 and 5 in 1; and, SM grade I in 5, II in 3, III in 3, IV in 4 and V in 1 patients, respectively. AA associated AVMs were classified as: (I) Flow-related proximal (n = 2); (II) flow-related distal (n = 3); (III) intranidal (n = 5); (IV) extra-intranidal (n = 2); (V) remote major ipsilateral (n = 1); (VI) remote major contralateral (n = 1); (VII) deep perforator related (n = 1); (VIII) superficial (n = 1); and (IX) distal (n = 0). Their treatment strategy included: Flow related AA, SM I-III LF AVM: aneurysm clipping with AVM excision; nidal-extranidal AA, SM I-III LF AVM: Excision or embolization of both AA + AVM; nidal-extranidal and perforator-related AA, SM IV-V HF AVM: Only endovascular embolization or radiosurgery. Surgical decision-making for remote AA took into account their ipsilateral/contralateral filling status and vessel dominance; and, for AA associated with SM III HF AVM, it varied in each patient based on diffuseness of AVM nidus, flow across arteriovenous fistula and eloquence of cortex. Follow up (F/U) (23.29 months; range: 1.5-69 months) mRS scores were 0 in 12, 2 in 2, 3 in 1 and 6 in 1 patients, respectively. Patients with intracranial AVMs should be screened for concurrent AAs. Further grading, management protocols and prognostication should particularly "focus on the aneurysm."

A benchmark for evaluation of algorithms for identification of cellular correlates of clinical outcomes.

PubMed

Aghaeepour, Nima; Chattopadhyay, Pratip; Chikina, Maria; Dhaene, Tom; Van Gassen, Sofie; Kursa, Miron; Lambrecht, Bart N; Malek, Mehrnoush; McLachlan, G J; Qian, Yu; Qiu, Peng; Saeys, Yvan; Stanton, Rick; Tong, Dong; Vens, Celine; Walkowiak, Sławomir; Wang, Kui; Finak, Greg; Gottardo, Raphael; Mosmann, Tim; Nolan, Garry P; Scheuermann, Richard H; Brinkman, Ryan R

2016-01-01

The Flow Cytometry: Critical Assessment of Population Identification Methods (FlowCAP) challenges were established to compare the performance of computational methods for identifying cell populations in multidimensional flow cytometry data. Here we report the results of FlowCAP-IV where algorithms from seven different research groups predicted the time to progression to AIDS among a cohort of 384 HIV+ subjects, using antigen-stimulated peripheral blood mononuclear cell (PBMC) samples analyzed with a 14-color staining panel. Two approaches (FlowReMi.1 and flowDensity-flowType-RchyOptimyx) provided statistically significant predictive value in the blinded test set. Manual validation of submitted results indicated that unbiased analysis of single cell phenotypes could reveal unexpected cell types that correlated with outcomes of interest in high dimensional flow cytometry datasets. © 2015 International Society for Advancement of Cytometry.

Critical capillary channel flow

NASA Astrophysics Data System (ADS)

Grah, Aleksander; Klatte, Jörg; Dreyer, Michael E.

The main subject are numerical studies on capillary channel flow, based on results of the sounding rocket experiments TEXUS 41/42. The flow through a capillary channel is established by a gear pump at the outlet. The channel, consists of two parallel glass plates with a width of 25 mm, a gap of 10 mm and a length of 12 mm. The meniscus of a compensation tube maintains a constant system pressure. Steady and dynamic pressure effects in the system force the surfaces to bend inwards. A maximum flow rate is achieved when the free surface collapses and gas ingestion occurs at the outlet. This critical flow rate depends on the channel geometry, the flow regime and the liquid properties. The aim of the experiments is the determination of the free surface shape and to find the maximum flow rate. In order to study the unsteady liquid loop behaviour, a dimensionless transient model was developed. It is based on the unsteady Bernoulli equation, the unsteady continuity equation and geometrical conditions for the surface curvature and the flow cross-section. The pressure is related to the curvature of the free liquid surface by the dimensionless Gauss-Laplace equation with two principal radii. The experimental and evaluated contour data shows good agreement for a sequence of transient flow rate perturbations. The surface oscillation frequencies and amplitudes can be predicted with quite high accuracy. The dynamic of the pump is defined by the increase of the flow rate in a time period. To study the unsteady system behavior in the "worst case", we use a perturbations related to the natural frequency of the oscillating liquid. In the case of steady flow at maximum flow rate, when the "choking" effect occurs, the surfaces collapse and cause gas ingestion into the channel. This effect is related to the Speed Index. At the critical flow rate the Speed Index reaches the value Sca = 1, in analogy to the Mach Number. Unsteady choking does not necessarily cause surface collapse. We show, that temporarily Speed Index values exceeding One may be achieved for a perfectly stable supercritical dynamic flow. As a supercritical criterion for the dynamic free surface stability we define a Dynamic Index D considering the local capillary pressure and the convective pressure, which is a function of the local velocity. The Dynamic Index is below One for stable flow while D = 1 indicates surface collapse. This studies result in a stability diagram, which defines the limits of flow dynamics and the maximum unsteady flow rate. It may serve as a road map for open capillary channel flow control.

Blood flow measurement of human skeletal muscle during various exercise intensity using diffuse correlation spectroscopy (DCS)

NASA Astrophysics Data System (ADS)

Murakami, Yuya; Ono, Yumie; Ichinose, Masashi

2017-02-01

We studied blood flow dynamics of active skeletal muscle using diffuse correlation spectroscopy (DCS), an emerging optical modality that is suitable for noninvasive quantification of microcirculation level in deep tissue. Seven healthy subjects conducted 0.5 Hz dynamic handgrip exercise for 3 minutes at intensities of 10, 20, 30, and 50 % of maximal voluntary contraction (MVC). DCS could detect the time-dependent increase of the blood flow response of the forearm muscle for continuous exercises, and the increase ratios of the mean blood flow through the exercise periods showed good correlation with the exercise intensities. We also compared blood flow responses detected from DCS with two different photon sampling rates and found that an appropriate photon sampling rates should be selected to follow the wide-ranged increase in the muscle blood flow with dynamic exercise. Our results demonstrate the possibility for utilizing DCS in a field of sports medicine to noninvasively evaluate the dynamics of blood flow in the active muscles.

Dynamic coupling of subsurface and seepage flows solved within a regularized partition formulation

NASA Astrophysics Data System (ADS)

Marçais, J.; de Dreuzy, J.-R.; Erhel, J.

2017-11-01

Hillslope response to precipitations is characterized by sharp transitions from purely subsurface flow dynamics to simultaneous surface and subsurface flows. Locally, the transition between these two regimes is triggered by soil saturation. Here we develop an integrative approach to simultaneously solve the subsurface flow, locate the potential fully saturated areas and deduce the generated saturation excess overland flow. This approach combines the different dynamics and transitions in a single partition formulation using discontinuous functions. We propose to regularize the system of partial differential equations and to use classic spatial and temporal discretization schemes. We illustrate our methodology on the 1D hillslope storage Boussinesq equations (Troch et al., 2003). We first validate the numerical scheme on previous numerical experiments without saturation excess overland flow. Then we apply our model to a test case with dynamic transitions from purely subsurface flow dynamics to simultaneous surface and subsurface flows. Our results show that discretization respects mass balance both locally and globally, converges when the mesh or time step are refined. Moreover the regularization parameter can be taken small enough to ensure accuracy without suffering of numerical artefacts. Applied to some hundreds of realistic hillslope cases taken from Western side of France (Brittany), the developed method appears to be robust and efficient.

Dynamic stall reattachment revisited

NASA Astrophysics Data System (ADS)

Mulleners, Karen

2017-11-01

Dynamic stall on pitching airfoils is an important practical problem that affects for example rotary wing aircraft and wind turbines. It also comprises a number of interesting fundamental fluid dynamical phenomena such as unsteady flow separation, vortex formation and shedding, unsteady flow reattachment, and dynamic hysteresis. Following up on past efforts focussing on the separation development, we now revisited the flow reattachment or stall recovery process. Experimental time-resolved velocity field and surface pressure data for a two-dimensional sinusoidally pitching airfoil with various reduced frequencies was analysed using different Eulerian, Lagrangian, and modal decomposition methods. This complementary analysis resulted in the identification of the chain of events that play a role in the flow reattachment process, a detailed description of that role, and characterisation of the individual events by the governing time-scales and flow features.

A novel technique to study pore-forming peptides in a natural membrane.

PubMed

Vedovato, Natascia; Rispoli, Giorgio

2007-09-01

The biophysical characteristics and the pore formation dynamics of synthetic or naturally occurring peptides forming membrane-spanning channels were investigated by using isolated photoreceptor rod outer segments (OS) recorded in whole-cell configuration. Once blocking the two OS endogenous conductances (the cGMP channels by light and the Na(+):Ca(2+),K(+) exchanger by removing one of the transported ion species from both sides of the membrane, i.e. K(+), Na(+) or Ca(2+)), the OS membrane resistance (R ( m )) was typically larger than 1 GOmega in the presence of 1 mM external Ca(2+). Therefore, any exogenous current could be studied down to the single channel level. The peptides were applied to (and removed from) the extracellular OS side in approximately 50 ms with a computer-controlled microperfusion system, in which every perfusion parameter, as the rate of solution flow, the temporal sequence of solution changes or the number of automatic, self-washing cycles were controlled by a user-friendly interface. This technique was then used to determine the biophysical properties and the pore formation dynamics of antibiotic peptaibols, as the native alamethicin mixture, the synthesized major component of the neutral fraction (F50/5) of alamethicin, and the synthetic trichogin GA IV.

Direct Observation of Two Phase Flow Generated by an Alumina Seeded Grain in High Aspect Ratio Channels

DTIC Science & Technology

2010-06-01

1999 Submitted in partial fulfillment of the requirements for the degrees of MECHANICAL ENGINEER and MASTERS OF SCIENCE IN MECHANICAL...Advisor Dr. Anthony Gannon Second Reader Dr. Knox Milsaps Chairman, Department of Mechanical and Aerospace Engineering iv THIS...within high aspect ratio regions of advanced propellant grain designs and how this behavior affects flow through the combustion chamber and impacts

Time-dependent onshore tsunami response

USGS Publications Warehouse

Apotsos, Alex; Gelfenbaum, Guy R.; Jaffe, Bruce E.

2012-01-01

While bulk measures of the onshore impact of a tsunami, including the maximum run-up elevation and inundation distance, are important for hazard planning, the temporal evolution of the onshore flow dynamics likely controls the extent of the onshore destruction and the erosion and deposition of sediment that occurs. However, the time-varying dynamics of actual tsunamis are even more difficult to measure in situ than the bulk parameters. Here, a numerical model based on the non-linear shallow water equations is used to examine the effects variations in the wave characteristics, bed slope, and bottom roughness have on the temporal evolution of the onshore flow. Model results indicate that the onshore flow dynamics vary significantly over the parameter space examined. For example, the flow dynamics over steep, smooth morphologies tend to be temporally symmetric, with similar magnitude velocities generated during the run-up and run-down phases of inundation. Conversely, on shallow, rough onshore topographies the flow dynamics tend to be temporally skewed toward the run-down phase of inundation, with the magnitude of the flow velocities during run-up and run-down being significantly different. Furthermore, for near-breaking tsunami waves inundating over steep topography, the flow velocity tends to accelerate almost instantaneously to a maximum and then decrease monotonically. Conversely, when very long waves inundate over shallow topography, the flow accelerates more slowly and can remain steady for a period of time before beginning to decelerate. These results indicate that a single set of assumptions concerning the onshore flow dynamics cannot be applied to all tsunamis, and site specific analyses may be required.

Investigating the importance of flow when utilizing hyaluronan scaffolds for tissue engineering.

PubMed

Donegan, Gail C; Hunt, John A; Rhodes, Nicholas

2010-02-01

Esterified hyaluronan scaffolds offer significant advantages for tissue engineering. They are recognized by cellular receptors, interact with many other extracellular matrix proteins and their metabolism is mediated by intrinsic cellular pathways. In this study differences in the viability and structural integrity of vascular tissue models cultured on hyaluronan scaffolds under laminar flow conditions highlighted potential differences in the biodegradation kinetics, processes and end-products, depending on the culture environment. Critical factors are likely to include seeding densities and the duration and magnitude of applied biomechanical stress. Proteomic evaluation of the timing and amount of remodelling protein expression, the resulting biomechanical changes arising from this response and metabolic cell viability assay, together with examination of tissue morphology, were conducted in vascular tissue models cultured on esterified hyaluronan felt and PTFE mesh scaffolds. The vascular tissue models were derived using complete cell sheets derived from harvested and expanded umbilical cord vein cells. This seeding method utilizes high-density cell populations from the outset, while the cells are already supported by their own abundant extracellular matrix. Type I and type IV collagen expression in parallel with MMP-1 and MMP-2 expression were monitored in the tissue models over a 10 day culture period under laminar flow regimes using protein immobilization technologies. Uniaxial tensile testing and scanning electron microscopy were used to compare the resulting effects of hydrodynamic stimulation upon structural integrity, while viability assays were conducted to evaluate the effects of shear on metabolic function. The proteomic results showed that the hyaluronan felt-supported tissues expressed higher levels of all remodelling proteins than those cultured on PTFE mesh. Overall, a 21% greater expression of type I collagen, 24% higher levels of type IV collagen, 24% higher levels of MMP-1 and 34% more MMP-2 were observed during hydrodynamic stress. This was coupled with a loss of structural integrity in these models after the introduction of laminar flow, as compared to the increases in all mechanical properties observed in the PTFE mesh-supported tissues. However, under flow conditions, the hyaluronan-supported tissues showed some recovery of the viability originally lost during static culture conditions, in contrast to PTFE mesh-based models, where initial gains were followed by a decline in metabolic viability after applied shear stress. Proteomic, cell viability and mechanical testing data emphasized the need for extended in vitro evaluations to enable better understanding of multi-stage remodelling and reparative processes in tissues cultured on biodegradable scaffolds. This study also highlighted the possibility that in high-density tissue culture with a biodegradable component, dynamic conditions may be more conducive to optimal tissue development than the static environment because they facilitate the efficient removal of high concentrations of degradation end-products accumulating in the pericellular space.

SIMPLIFIED MODELING OF AIR FLOW DYNAMICS IN SSD RADON MITIGATION SYSTEMS FOR RESIDENCES WITH GRAVEL BEDS

EPA Science Inventory

In an attempt to better understand the dynamics of subslab air flow, the report suggests that subslab air flow induced by a central suction point be treated as radial air flow through a porous bed contained between two impermeable disks. (NOTE: Many subslab depressurization syste...

Dynamics of flow control in an emulated boundary layer-ingesting offset diffuser

NASA Astrophysics Data System (ADS)

Gissen, A. N.; Vukasinovic, B.; Glezer, A.

2014-08-01

Dynamics of flow control comprised of arrays of active (synthetic jets) and passive (vanes) control elements , and its effectiveness for suppression of total-pressure distortion is investigated experimentally in an offset diffuser, in the absence of internal flow separation. The experiments are conducted in a wind tunnel inlet model at speeds up to M = 0.55 using approach flow conditioning that mimics boundary layer ingestion on a Blended-Wing-Body platform. Time-dependent distortion of the dynamic total-pressure field at the `engine face' is measured using an array of forty total-pressure probes, and the control-induced distortion changes are analyzed using triple decomposition and proper orthogonal decomposition (POD). These data indicate that an array of the flow control small-scale synthetic jet vortices merge into two large-scale, counter-rotating streamwise vortices that exert significant changes in the flow distortion. The two most energetic POD modes appear to govern the distortion dynamics in either active or hybrid flow control approaches. Finally, it is shown that the present control approach is sufficiently robust to reduce distortion with different inlet conditions of the baseline flow.

Design and Implementation of a Characterization Test Rig for Evaluating High Bandwidth Liquid Fuel Flow Modulators

NASA Technical Reports Server (NTRS)

Saus, Joseph R.; Chang, Clarence T.; DeLaat, John C.; Vrnak, Daniel R.

2010-01-01

A test rig was designed and developed at the NASA Glenn Research Center (GRC) for the purpose of characterizing high bandwidth liquid fuel flow modulator candidates to determine their suitability for combustion instability control research. The test rig is capable of testing flow modulators at up to 600 psia supply pressure and flows of up to 2 gpm. The rig is designed to provide a quiescent flow into the test section in order to isolate the dynamic flow modulations produced by the test article. Both the fuel injector orifice downstream of the test article and the combustor are emulated. The effect of fuel delivery line lengths on modulator dynamic performance can be observed and modified to replicate actual fuel delivery systems. For simplicity, water is currently used as the working fluid, although future plans are to use jet fuel. The rig is instrumented for dynamic pressures and flows and a high-speed data system is used for dynamic data acquisition. Preliminary results have been obtained for one candidate flow modulator.

Control of unsteady separated flow associated with the dynamic stall of airfoils

NASA Technical Reports Server (NTRS)

Wilder, M. C.

1994-01-01

A unique active flow-control device is proposed for the control of unsteady separated flow associated with the dynamic stall of airfoils. The device is an adaptive-geometry leading-edge which will allow controlled, dynamic modification of the leading-edge profile of an airfoil while the airfoil is executing an angle-of-attack pitch-up maneuver. A carbon-fiber composite skin has been bench tested, and a wind tunnel model is under construction. A baseline parameter study of compressible dynamic stall was performed for flow over an NACA 0012 airfoil. Parameters included Mach number, pitch rate, pitch history, and boundary layer tripping. Dynamic stall data were recorded via point-diffraction interferometry and the interferograms were analyzed with in-house developed image processing software. A new high-speed phase-locked photographic image recording system was developed for real-time documentation of dynamic stall.

Phenotypic and Genomic Analysis of Hypervirulent Human-associated Bordetella bronchiseptica

PubMed Central

2012-01-01

Background B. bronchiseptica infections are usually associated with wild or domesticated animals, but infrequently with humans. A recent phylogenetic analysis distinguished two distinct B. bronchiseptica subpopulations, designated complexes I and IV. Complex IV isolates appear to have a bias for infecting humans; however, little is known regarding their epidemiology, virulence properties, or comparative genomics. Results Here we report a characterization of the virulence of human-associated complex IV B. bronchiseptica strains. In in vitro cytotoxicity assays, complex IV strains showed increased cytotoxicity in comparison to a panel of complex I strains. Some complex IV isolates were remarkably cytotoxic, resulting in LDH release levels in A549 cells that were 10- to 20-fold greater than complex I strains. In vivo, a subset of complex IV strains was found to be hypervirulent, with an increased ability to cause lethal pulmonary infections in mice. Hypercytotoxicity in vitro and hypervirulence in vivo were both dependent on the activity of the bsc T3SS and the BteA effector. To clarify differences between lineages, representative complex IV isolates were sequenced and their genomes were compared to complex I isolates. Although our analysis showed there were no genomic sequences that can be considered unique to complex IV strains, there were several loci that were predominantly found in complex IV isolates. Conclusion Our observations reveal a T3SS-dependent hypervirulence phenotype in human-associated complex IV isolates, highlighting the need for further studies on the epidemiology and evolutionary dynamics of this B. bronchiseptica lineage. PMID:22863321

An evaluation of Dynamic TOPMODEL in natural and human-impacted catchments for low flow simulation

NASA Astrophysics Data System (ADS)

Coxon, Gemma; Freer, Jim; Lane, Rosanna; Musuuza, Jude; Woods, Ross; Wagener, Thorsten; Howden, Nicholas

2017-04-01

Models of catchment hydrology are essential tools for drought risk management, often providing input to water resource system models, aiding our understanding of low flow processes within catchments and providing low flow simulations and predictions. However, simulating low flows is challenging as hydrological systems often demonstrate threshold effects in connectivity, non-linear groundwater contributions and a greater influence of anthropogenic modifications such as surface and ground water abstractions during low flow periods. These processes are typically not well represented in commonly used hydrological models due to knowledge, data and model limitations. Hence, a better understanding of the natural and human processes that occur during low flows, how these are represented within models and how they could be improved is required to be able to provide robust and reliable predictions of future drought events. The aim of this study is to assess the skill of dynamic TOPMODEL during low flows for both natural and human-impacted catchments. Dynamic TOPMODEL was chosen for this study as it is able to explicitly characterise connectivity and fluxes across landscapes using hydrological response units (HRU's) while still maintaining flexibility in how spatially complex the model is configured and what specific functions (i.e. abstractions or groundwater stores) are represented. We apply dynamic TOPMODEL across the River Thames catchment using daily time series of observed rainfall and potential evapotranspiration data for the period 1999 - 2014, covering two major droughts in the Thames catchment. Significantly, to assess the impact of abstractions on low flows across the Thames catchment, we incorporate functions to characterise over 3,500 monthly surface water and ground water abstractions covering the simulation period into dynamic TOPMODEL. We evaluate dynamic TOPMODEL at over 90 gauging stations across the Thames catchment against multiple signatures of catchment low-flow behaviour in a 'limits of acceptability' GLUE framework. We investigate differences in model performance between signatures, different low flow periods and for natural and human impacted catchments to better understand the ability of dynamic TOPMODEL to represent low flows in space and time. Finally, we discuss future developments of dynamic TOPMODEL to improve low flow simulation and the implications of these results for modelling hydrological extremes in natural and human impacted catchments across the UK and the world.

Flap flexibility amongst plasmepsins I, II, III, IV, and V: Sequence, structural, and molecular dynamics analyses.

PubMed

McGillewie, Lara; Soliman, Mahmoud E

2015-09-01

Herein, for the first time, we comparatively report the opening and closing of apo plasmepsin I - V. Plasmepsins belong the aspartic protease family of enzymes, and are expressed during the various stages of the P. falciparum lifecycle, the species responsible for the most lethal and virulent malaria to infect humans. Plasmepsin I, II, IV and HAP degrade hemoglobin from infected red blood cells, whereas plasmepsin V transport proteins crucial to the survival of the malaria parasite across the endoplasmic reticulum. Flap-structures covering the active site of aspartic proteases (such as HIV protease) are crucial to the conformational flexibility and dynamics of the protein, and ultimately control the binding landscape. The flap-structure in plasmepsins is made up of a flip tip in the N-terminal lying perpendicular to the active site, adjacent to the flexible loop region in the C-terminal. Using molecular dynamics, we propose three parameters to better describe the opening and closing of the flap-structure in apo plasmepsins. Namely, the distance, d1, between the flap tip and the flexible region; the dihedral angle, ϕ, to account for the twisting motion; and the TriCα angle, θ1. Simulations have shown that as the flap-structure twists, the flap and flexible region move apart opening the active site, or move toward each other closing the active site. The data from our study indicate that of all the plasmepsins investigated in the present study, Plm IV and V display the highest conformational flexibility and are more dynamic structures versus Plm I, II, and HAP. © 2015 Wiley Periodicals, Inc.

FORTRAN program for calculating velocities and streamlines on the hub-shroud mid-channel flow surface of an axial-or mixed-flow turbomachine. 2: Programmer's manual

NASA Technical Reports Server (NTRS)

Katsanis, T.; Mcnally, W. D.

1974-01-01

A FORTRAN-IV computer program, MERIDL, has been developed that obtains a subsonic or shock-free transonic flow solution on the hub-shroud mid-channel flow surface of a turbomachine. The blade row may be fixed or rotating and may be twisted and leaned. Flow may be axial or mixed, up to 45 deg from axial. Upstream and downstream flow variables can vary from hub to shroud, and provision is made to correct for loss of stagnation pressure. The results include velocities, streamlines, and flow angles on the flow surface and approximate blade surface velocities. Subsonic solutions are obtained by a finite-difference stream-function solution. Transonic solutions are obtained by a velocity-gradient method, using information from a finite-difference stream-function solution at a reduced mass flow.

Liquid crystal dynamic flow control by bidirectional alignment surface

NASA Astrophysics Data System (ADS)

Li, Y. W.; Lee, C. Y.; Kwok, H. S.

2009-02-01

We investigate the behavior of liquid crystal dynamic flow in a cell with a bidirectional alignment (BDA) surface. Numerical simulations show that with a BDA surface having a pitch comparable to the cell gap d, the liquid crystal dynamic flow direction can be controlled by the driving voltage. Such an effect can be applied to bistable twisted nematic displays without the need for anchoring breaking.

Free-Surface flow dynamics and its effect on travel time distribution in unsaturated fractured zones - findings from analogue percolation experiments

NASA Astrophysics Data System (ADS)

Noffz, Torsten; Kordilla, Jannes; Dentz, Marco; Sauter, Martin

2017-04-01

Flow in unsaturated fracture networks constitutes a high potential for rapid mass transport and can therefore possibly contributes to the vulnerability of aquifer systems. Numerical models are generally used to predict flow and transport and have to reproduce various complex effects of gravity-driven flow dynamics. However, many classical volume-effective modelling approaches often do not grasp the non-linear free surface flow dynamics and partitioning behaviour at fracture intersections in unsaturated fracture networks. Better process understanding can be obtained by laboratory experiments, that isolate single aspects of the mass partitioning process, which influence travel time distributions and allow possible cross-scale applications. We present a series of percolation experiments investigating partitioning dynamics of unsaturated multiphase flow at an individual horizontal fracture intersection. A high precision multichannel dispenser is used to establish gravity-driven free surface flow on a smooth and vertical PMMA (poly(methyl methacrylate)) surface at rates ranging from 1.5 to 4.5 mL/min to obtain various flow modes (droplets; rivulets). Cubes with dimensions 20 x 20 x 20 cm are used to create a set of simple geometries. A digital balance provides continuous real-time cumulative mass bypassing the network. The influence of variable flow rate, atmospheric pressure and temperature on the stability of flow modes is shown in single-inlet experiments. Droplet and rivulet flow are delineated and a transition zone exhibiting mixed flow modes can be determined. Furthermore, multi-inlet setups with constant total inflow rates are used to reduce variance and the effect of erratic free-surface flow dynamics. Investigated parameters include: variable aperture widths df, horizontal offsets dv of the vertical fracture surface and alternating injection methods for both droplet and rivulet flow. Repetitive structures with several horizontal fractures extend arrival times but also complexity and variance. Finally, impacts of variable geometric features and flow modes on partitioning dynamics are highlighted by normalized fracture inflow rates. For higher flow rates, i.e. rivulet flows dominates, the effectiveness of filling horizontal fractures strongly increases. We demonstrate that the filling can be described by plug flow, which transitions into a Washburn-type flow at later times, and derive an analytical solution for the case of rivulet flows. Droplet flow dominated flow experiments exhibit a high bypass efficiency, which cannot be described by plug-flow, however, they also transition into a Washburn stage.

Multimodal assessment of spatial distribution of drug-tracer uptake by brain tissue after intra-arterial injections

NASA Astrophysics Data System (ADS)

Singh-Moon, Rajinder; Chaudhuri, Durba; Wang, Mei; Straubinger, Robert; Bigio, Irving J.; Joshi, Shailendra

2014-02-01

It is challenging to track the rapid changes in drug concentrations after intra-arterial (IA) administration to elucidate the pharmacokinetics of this method of drug delivery. Traditional pharmacokinetic parameters (such as protein binding) that are highly relevant to intravenous (IV) administration do not seem to apply to IA injections. Regional drug delivery is affected by the biomechanics of drug injection, resting blood flow, and local tissue extraction. In-vivo and ex-vivo, optical methods for spatial mapping of drug deposition can assist in visualizing drug distributions and aid in the screening of potential drugs and carrier candidates. We present a multimodal approach for the assessment of drug distribution in postmortem tissue specimens using diffuse reflectance spectroscopy, multispectral imaging, and confocal microscopy and demonstrate feasibility of distinguishing route of administration advantages of liposome-dye conjugate delivery. The results of this study suggest that insight on drug dynamics gained by this aggregated approach can be used to help screen and/or optimize potential drug candidates and drug delivery protocols.

Two Solar Tornadoes Observed with the Interface Region Imaging Spectrograph

NASA Astrophysics Data System (ADS)

Yang, Zihao; Tian, Hui; Peter, Hardi; Su, Yang; Samanta, Tanmoy; Zhang, Jingwen; Chen, Yajie

2018-01-01

The barbs or legs of some prominences show an apparent motion of rotation, which are often termed solar tornadoes. It is under debate whether the apparent motion is a real rotating motion, or caused by oscillations or counter-streaming flows. We present analysis results from spectroscopic observations of two tornadoes by the Interface Region Imaging Spectrograph. Each tornado was observed for more than 2.5 hr. Doppler velocities are derived through a single Gaussian fit to the Mg II k 2796 Å and Si IV 1393 Å line profiles. We find coherent and stable redshifts and blueshifts adjacent to each other across the tornado axes, which appears to favor the interpretation of these tornadoes as rotating cool plasmas with temperatures of 104 K–105 K. This interpretation is further supported by simultaneous observations of the Atmospheric Imaging Assembly on board the Solar Dynamics Observatory, which reveal periodic motions of dark structures in the tornadoes. Our results demonstrate that spectroscopic observations can provide key information to disentangle different physical processes in solar prominences.

Nonlinear response of ultrasound contrast agent microbubbles: From fundamentals to applications

NASA Astrophysics Data System (ADS)

Teng, Xu-Dong; Guo, Xia-Sheng; Tu, Juan; Zhang, Dong

2016-12-01

Modelling and biomedical applications of ultrasound contrast agent (UCA) microbubbles have attracted a great deal of attention. In this review, we summarize a series of researches done in our group, including (i) the development of an all-in-one solution of characterizing coated bubble parameters based on the light scattering technique and flow cytometry; (ii) a novel bubble dynamic model that takes into consideration both nonlinear shell elasticity and viscosity to eliminate the dependences of bubble shell parameters on bubble size; (iii) the evaluation of UCA inertial cavitation threshold and its relationship with shell parameters; and (iv) the investigations of transfection efficiency and the reduction of cytotoxicity in gene delivery facilitated by UCAs excited by ultrasound exposures. Projects supported by the National Natural Science Foundation of China (Grant Nos. 81127901, 81227004, 11374155, 11274170, 11274176, 11474001, 11474161, 11474166, and 11674173), the National High-Technology Research and Development Program, China (Grant No. 2012AA022702), and Qing Lan Project of Jiangsu Province, China.

The investigation of parachute fabric permeability under an unsteady pressure differential

NASA Astrophysics Data System (ADS)

Rondeau, Nichole C.

An apparatus for assessing permeability of textiles subjected to time-varying pressure differentials is presented. A Computer Numerically Controlled Piston Permeability Apparatus (CNC-PPA) that can control the volume flow rate through a fabric has been designed and built. This test device has been developed in an effort to improve the understanding and design choices for aerodynamic decelerators. Preliminary results for a low permeability fabric (PIA-C-44378, Type IV) under both steady and unsteady loads are presented. The results from this investigation do indicate a small effect of unsteady pressure differential on the fabric permeability. The fabric permeability is slightly higher than the static permeability when the pressure differential is increasing with respect to time and the opposite is true when the pressure differential is decreasing. This change in permeability is more pronounced as the pressure is higher and the pressure changes more rapidly with respect to time, suggesting dynamic permeability likely affects highly unsteady phenomena such as parachute opening.

Deconvolution of reacting-flow dynamics using proper orthogonal and dynamic mode decompositions

NASA Astrophysics Data System (ADS)

Roy, Sukesh; Hua, Jia-Chen; Barnhill, Will; Gunaratne, Gemunu H.; Gord, James R.

2015-01-01

Analytical and computational studies of reacting flows are extremely challenging due in part to nonlinearities of the underlying system of equations and long-range coupling mediated by heat and pressure fluctuations. However, many dynamical features of the flow can be inferred through low-order models if the flow constituents (e.g., eddies or vortices) and their symmetries, as well as the interactions among constituents, are established. Modal decompositions of high-frequency, high-resolution imaging, such as measurements of species-concentration fields through planar laser-induced florescence and of velocity fields through particle-image velocimetry, are the first step in the process. A methodology is introduced for deducing the flow constituents and their dynamics following modal decomposition. Proper orthogonal (POD) and dynamic mode (DMD) decompositions of two classes of problems are performed and their strengths compared. The first problem involves a cellular state generated in a flat circular flame front through symmetry breaking. The state contains two rings of cells that rotate clockwise at different rates. Both POD and DMD can be used to deconvolve the state into the two rings. In POD the contribution of each mode to the flow is quantified using the energy. Each DMD mode can be associated with an energy as well as a unique complex growth rate. Dynamic modes with the same spatial symmetry but different growth rates are found to be combined into a single POD mode. Thus, a flow can be approximated by a smaller number of POD modes. On the other hand, DMD provides a more detailed resolution of the dynamics. Two classes of reacting flows behind symmetric bluff bodies are also analyzed. In the first, symmetric pairs of vortices are released periodically from the two ends of the bluff body. The second flow contains von Karman vortices also, with a vortex being shed from one end of the bluff body followed by a second shedding from the opposite end. The way in which DMD can be used to deconvolve the second flow into symmetric and von Karman vortices is demonstrated. The analyses performed illustrate two distinct advantages of DMD: (1) Unlike proper orthogonal modes, each dynamic mode is associated with a unique complex growth rate. By comparing DMD spectra from multiple nominally identical experiments, it is possible to identify "reproducible" modes in a flow. We also find that although most high-energy modes are reproducible, some are not common between experimental realizations; in the examples considered, energy fails to differentiate between reproducible and nonreproducible modes. Consequently, it may not be possible to differentiate reproducible and nonreproducible modes in POD. (2) Time-dependent coefficients of dynamic modes are complex. Even in noisy experimental data, the dynamics of the phase of these coefficients (but not their magnitude) are highly regular. The phase represents the angular position of a rotating ring of cells and quantifies the downstream displacement of vortices in reacting flows. Thus, it is suggested that the dynamical characterizations of complex flows are best made through the phase dynamics of reproducible DMD modes.

Methodology Development of a Gas-Liquid Dynamic Flow Regime Transition Model

NASA Astrophysics Data System (ADS)

Doup, Benjamin Casey

Current reactor safety analysis codes, such as RELAP5, TRACE, and CATHARE, use flow regime maps or flow regime transition criteria that were developed for static fully-developed two-phase flows to choose interfacial transfer models that are necessary to solve the two-fluid model. The flow regime is therefore difficult to identify near the flow regime transitions, in developing two-phase flows, and in transient two-phase flows. Interfacial area transport equations were developed to more accurately predict the dynamic nature of two-phase flows. However, other model coefficients are still flow regime dependent. Therefore, an accurate prediction of the flow regime is still important. In the current work, the methodology for the development of a dynamic flow regime transition model that uses the void fraction and interfacial area concentration obtained by solving three-field the two-fluid model and two-group interfacial area transport equation is investigated. To develop this model, detailed local experimental data are obtained, the two-group interfacial area transport equations are revised, and a dynamic flow regime transition model is evaluated using a computational fluid dynamics model. Local experimental data is acquired for 63 different flow conditions in bubbly, cap-bubbly, slug, and churn-turbulent flow regimes. The measured parameters are the group-1 and group-2 bubble number frequency, void fraction, interfacial area concentration, and interfacial bubble velocities. The measurements are benchmarked by comparing the prediction of the superficial gas velocities, determined using the local measurements with those determined from volumetric flow rate measurements and the agreement is generally within +/-20%. The repeatability four-sensor probe construction process is within +/-10%. The repeatability of the measurement process is within +/-7%. The symmetry of the test section is examined and the average agreement is within +/-5.3% at z/D = 10 and +/-3.4% at z/D = 32. Revised source/sink terms for the two-group interfacial area transport equations are derived and fit to area-averaged experimental data to determine new model coefficients. The average agreement between this model and the experiment data for the void fraction and interfacial area concentration is 10.6% and 15.7%, respectively. This revised two-group interfacial area transport equation and the three-field two-fluid model are used to solve for the group-1 and group-2 interfacial area concentration and void fraction. These values and a dynamic flow regime transition model are used to classify the flow regimes. The flow regimes determined using this model are compared with the flow regimes based on the experimental data and on a flow regime map using Mishima and Ishii's (1984) transition criteria. The dynamic flow regime transition model is shown to predict the flow regimes dynamically and has improved the prediction of the flow regime over that using a flow regime map. Safety codes often employ the one-dimensional two-fluid model to model two-phase flows. The area-averaged relative velocity correlation necessary to close this model is derived from the drift flux model. The effects of the necessary assumptions used to derive this correlation are investigated using local measurements and these effects are found to have a limited impact on the prediction of the area-averaged relative velocity.

Extensional channel flow revisited: a dynamical systems perspective

PubMed Central

Meseguer, Alvaro; Mellibovsky, Fernando; Weidman, Patrick D.

2017-01-01

Extensional self-similar flows in a channel are explored numerically for arbitrary stretching–shrinking rates of the confining parallel walls. The present analysis embraces time integrations, and continuations of steady and periodic solutions unfolded in the parameter space. Previous studies focused on the analysis of branches of steady solutions for particular stretching–shrinking rates, although recent studies focused also on the dynamical aspects of the problems. We have adopted a dynamical systems perspective, analysing the instabilities and bifurcations the base state undergoes when increasing the Reynolds number. It has been found that the base state becomes unstable for small Reynolds numbers, and a transitional region including complex dynamics takes place at intermediate Reynolds numbers, depending on the wall acceleration values. The base flow instabilities are constitutive parts of different codimension-two bifurcations that control the dynamics in parameter space. For large Reynolds numbers, the restriction to self-similarity results in simple flows with no realistic behaviour, but the flows obtained in the transition region can be a valuable tool for the understanding of the dynamics of realistic Navier–Stokes solutions. PMID:28690413

Potential of turbidity monitoring for real time control of pollutant discharge in sewers during rainfall events.

PubMed

Lacour, C; Joannis, C; Gromaire, M-C; Chebbo, G

2009-01-01

Turbidity sensors can be used to continuously monitor the evolution of pollutant mass discharge. For two sites within the Paris combined sewer system, continuous turbidity, conductivity and flow data were recorded at one-minute time intervals over a one-year period. This paper is intended to highlight the variability in turbidity dynamics during wet weather. For each storm event, turbidity response aspects were analysed through different classifications. The correlation between classification and common parameters, such as the antecedent dry weather period, total event volume per impervious hectare and both the mean and maximum hydraulic flow for each event, was also studied. Moreover, the dynamics of flow and turbidity signals were compared at the event scale. No simple relation between turbidity responses, hydraulic flow dynamics and the chosen parameters was derived from this effort. Knowledge of turbidity dynamics could therefore potentially improve wet weather management, especially when using pollution-based real-time control (P-RTC) since turbidity contains information not included in hydraulic flow dynamics and not readily predictable from such dynamics.

Separation Dynamics of Controlled Internal Flow in an Adverse Pressure Gradient

NASA Astrophysics Data System (ADS)

Peterson, C. J.; Vukasinovic, B.; Glezer, A.

2017-11-01

The effects of fluidic actuation on the dynamic evolution of aggressive internal flow separation is investigated at speeds up to M = 0.4 within a constant-width diffuser branching off of a primary flow duct. It is shown that a spanwise array of fluidic actuators upstream of the separation actively controls the flow constriction (and losses) within the diffuser and consequently the local pressure gradient at its entrance. The effectiveness of the actuation, as may be measured by the increased flow rate that is diverted through the diffuser, scales with its flow rate coefficient. In the presence of actuation (0.7% mass fraction), the mass flow rate in the primary duct increases by 10% while the fraction of the diverted mass flow rate in the diffuser increases by more than 45%. The flow dynamics near separation in the absence and presence of actuation are characterized using high speed particle image velocimetry and analyzed using proper orthogonal and spectral decompositions. In particular, the spectral contents of the incipient boundary layer separation are compared in the absence and presence of actuation with emphasis on the changes in local dynamics near separation as the characteristic cross stream scale of the boundary layer increases with separation delay.

Dynamics of a surge observed in the C IV and H alpha lines

NASA Technical Reports Server (NTRS)

Schmieder, B.; Mein, P.; Vial, J.-C.; Tandberg-Hanssen, E.

1983-01-01

Time sequences of a surge have been obtained in Active Region 2701 during a coordinated SMY program, on October 2nd, 1980, while the MSDP spectrograph operated in H-alpha at the Meudon Solar Tower and the UVSP spectrometer on SMM observed in the 1548 A C IV resonance line. The cold (H-alpha) and hot (C IV) material follow the same channel, and the event lasts about 10 min in both lines. A good correlation is found between H-alpha and C IV velocities; radial velocities along the surge are in the range 40-60 km/s in both cases. The observations are consistent with the hypothesis that a pressure gradient drives the surge. The H-alpha data seem to indicate the presence of a shock wave in the chromosphere, while the C IV quantities (velocities, accelerations) vary on a very short time scale. Their maxima occur at some locations which could be interpreted as 'pinched' zones.

Analysis of antigen-induced changes in pulmonary mechanics in sensitized inbred rats.

PubMed

Holroyde, M C; Smith, S Y; Holme, G

1982-05-01

An inbred line of rats was derived which develop marked and consistent dyspnea following sensitization and then exposure to aerosolized antigen. This pulmonary response was investigated in detail by determining forced pulmonary mechanics to derive respiratory rate, peak expiratory flow rate (PEFR), forced vital capacity (FVC), forced expiratory volume in 0.1 s (FEV0.1), and maximal midexpiratory flow rate (MMFR). Challenging anesthetized rats for 5 min with an aerosol of 3% egg albumin produced minimal change in respiratory rate, a 20% fall in PEFR, a 50% fall in FVC, and a 30% decrease in FEV0.1 and MMFR. The response could be inhibited or reversed by salbutamol (0.5 mg/kg, i.v.) and aminophylline (25 mg/kg, i.v.) administered either before or after challenge. The pulmonary changes are consistent with antigen-induced asthma in the rats. The response shows similarities to human asthma and may provide a relevant experimental model.

Local dynamic subgrid-scale models in channel flow

NASA Technical Reports Server (NTRS)

Cabot, William H.

1994-01-01

The dynamic subgrid-scale (SGS) model has given good results in the large-eddy simulation (LES) of homogeneous isotropic or shear flow, and in the LES of channel flow, using averaging in two or three homogeneous directions (the DA model). In order to simulate flows in general, complex geometries (with few or no homogeneous directions), the dynamic SGS model needs to be applied at a local level in a numerically stable way. Channel flow, which is inhomogeneous and wall-bounded flow in only one direction, provides a good initial test for local SGS models. Tests of the dynamic localization model were performed previously in channel flow using a pseudospectral code and good results were obtained. Numerical instability due to persistently negative eddy viscosity was avoided by either constraining the eddy viscosity to be positive or by limiting the time that eddy viscosities could remain negative by co-evolving the SGS kinetic energy (the DLk model). The DLk model, however, was too expensive to run in the pseudospectral code due to a large near-wall term in the auxiliary SGS kinetic energy (k) equation. One objective was then to implement the DLk model in a second-order central finite difference channel code, in which the auxiliary k equation could be integrated implicitly in time at great reduction in cost, and to assess its performance in comparison with the plane-averaged dynamic model or with no model at all, and with direct numerical simulation (DNS) and/or experimental data. Other local dynamic SGS models have been proposed recently, e.g., constrained dynamic models with random backscatter, and with eddy viscosity terms that are averaged in time over material path lines rather than in space. Another objective was to incorporate and test these models in channel flow.

Flow-pattern identification and nonlinear dynamics of gas-liquid two-phase flow in complex networks.

PubMed

Gao, Zhongke; Jin, Ningde

2009-06-01

The identification of flow pattern is a basic and important issue in multiphase systems. Because of the complexity of phase interaction in gas-liquid two-phase flow, it is difficult to discern its flow pattern objectively. In this paper, we make a systematic study on the vertical upward gas-liquid two-phase flow using complex network. Three unique network construction methods are proposed to build three types of networks, i.e., flow pattern complex network (FPCN), fluid dynamic complex network (FDCN), and fluid structure complex network (FSCN). Through detecting the community structure of FPCN by the community-detection algorithm based on K -mean clustering, useful and interesting results are found which can be used for identifying five vertical upward gas-liquid two-phase flow patterns. To investigate the dynamic characteristics of gas-liquid two-phase flow, we construct 50 FDCNs under different flow conditions, and find that the power-law exponent and the network information entropy, which are sensitive to the flow pattern transition, can both characterize the nonlinear dynamics of gas-liquid two-phase flow. Furthermore, we construct FSCN and demonstrate how network statistic can be used to reveal the fluid structure of gas-liquid two-phase flow. In this paper, from a different perspective, we not only introduce complex network theory to the study of gas-liquid two-phase flow but also indicate that complex network may be a powerful tool for exploring nonlinear time series in practice.

Pharmacokinetics and clinical effects of phenytoin and fosphenytoin in children with severe malaria and status epilepticus

PubMed Central

Ogutu, Bernhards R; Newton, Charles R J C; Muchohi, Simon N; Otieno, Godfrey O; Edwards, Geoffrey; Watkins, William M; Kokwaro, Gilbert O

2003-01-01

Aims Status epilepticus is common in children with severe falciparum malaria and is associated with poor outcome. Phenytoin is often used to control status epilepticus, but its water-soluble prodrug, fosphenytoin, may be more useful as it is easier to administer. We studied the pharmacokinetics and clinical effects of phenytoin and fosphenytoin sodium in children with severe falciparum malaria and status epilepticus. Methods Children received intravenous (i.v.) phenytoin as a 18 mg kg−1 loading dose infused over 20 min followed by a 2.5 mg kg−1 12 hourly maintenance dose infused over 5 min (n = 11), or i.v. fosphenytoin, administered at a rate of 50 mg min−1 phenytoin sodium equivalents (PE; n = 16), or intramuscular (i.m.) fosphenytoin as a 18 mg kg−1 loading dose followed by 2.5 mg kg−1 12 hourly of PE (n = 11). Concentrations of phenytoin in plasma and cerebrospinal fluid (CSF), frequency of seizures, cardiovascular effects (respiratory rate, blood pressure, trancutaneous oxygen tension and level of consciousness) and middle cerebral artery (MCA) blood flow velocity were monitored. Results After all routes of administration, a plasma unbound phenytoin concentration of more than 1 µg ml−1 was rapidly (within 5–20 min) attained. Mean (95% confidence interval) steady state free phenytoin concentrations were 2.1 (1.7, 2.4; i.v. phenytoin, n = 6), 1.5 (0.96, 2.1; i.v. fosphenytoin, n = 11) and 1.4 (0.5, 2.4; i.m. fosphenytoin, n = 6), and were not statistically different for the three routes of administration. Median times (range) to peak plasma phenytoin concentrations following the loading dose were 0.08 (0.08–0.17), 0.37 (0.33–0.67) and 0.38 (0.17–2.0) h for i.v. fosphenytoin, i.v. phenytoin and i.m. fosphenytoin, respectively. CSF: plasma phenytoin concentration ratio ranged from 0.12 to 0.53 (median = 0.28, n = 16). Status epilepticus was controlled in only 36% (4/11) following i.v. phenytoin, 44% (7/16), following i.v. fosphenytoin and 64% (7/11) following i.m. fosphenytoin administration, respectively. Cardiovascular parameters and MCA blood flow were not affected by phenytoin administration. Conclusions Phenytoin and fosphenytoin administration at the currently recommended doses achieve plasma unbound phenytoin concentrations within the therapeutic range with few cardiovascular effects. Administration of fosphenytoin i.v. or i.m. offers a practical and convenient alternative to i.v. phenytoin. However, the inadequate control of status epilepticus despite rapid achievement of therapeutic unbound phenytoin concentrations warrants further investigation. PMID:12848783

Self-sustaining turbulence in a restricted nonlinear model of plane Couette flow

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thomas, Vaughan L.; Gayme, Dennice F.; Lieu, Binh K.

2014-10-15

This paper demonstrates the maintenance of self-sustaining turbulence in a restricted nonlinear (RNL) model of plane Couette flow. The RNL system is derived directly from the Navier-Stokes equations and permits higher resolution studies of the dynamical system associated with the stochastic structural stability theory (S3T) model, which is a second order approximation of the statistical state dynamics of the flow. The RNL model shares the dynamical restrictions of the S3T model but can be easily implemented by reducing a DNS code so that it retains only the RNL dynamics. Comparisons of turbulence arising from DNS and RNL simulations demonstrate thatmore » the RNL system supports self-sustaining turbulence with a mean flow as well as structural and dynamical features that are consistent with DNS. These results demonstrate that the simplified RNL system captures fundamental aspects of fully developed turbulence in wall-bounded shear flows and motivate use of the RNL/S3T framework for further study of wall-turbulence.« less

Nitric oxide plays a role in the regulation of adrenal blood flow and adrenocorticomedullary functions in the llama fetus

PubMed Central

Riquelme, Raquel A; Sánchez, Gina; Liberona, Leonel; Sanhueza, Emilia M; Giussani, Dino A; Blanco, Carlos E; Hanson, Mark A; Llanos, Aníbal J

2002-01-01

The hypothesis that nitric oxide plays a key role in the regulation of adrenal blood flow and plasma concentrations of cortisol and catecholamines under basal and hypoxaemic conditions in the llama fetus was tested. At 0.6-0.8 of gestation, 11 llama fetuses were surgically prepared for long-term recording under anaesthesia with vascular and amniotic catheters. Following recovery all fetuses underwent an experimental protocol based on 1 h of normoxaemia, 1 h of hypoxaemia and 1 h of recovery. In nine fetuses, the protocol occurred during fetal i.v. infusion with saline and in five fetuses during fetal i.v. treatment with the nitric oxide synthase inhibitor l-NAME. Adrenal blood flow was determined by the radiolabelled microsphere method during each of the experimental periods during saline infusion and treatment with l-NAME. Treatment with l-NAME during normoxaemia led to a marked fall in adrenal blood flow and a pronounced increase in plasma catecholamine concentrations, but it did not affect plasma ACTH or cortisol levels. In saline-infused fetuses, acute hypoxaemia elicited an increase in adrenal blood flow and in plasma ACTH, cortisol, adrenaline and noradrenaline concentrations. Treatment with l-NAME did not affect the increase in fetal plasma ACTH, but prevented the increments in adrenal blood flow and in plasma cortisol and adrenaline concentrations during hypoxaemia in the llama fetus. In contrast, l-NAME further enhanced the increase in fetal plasma noradrenaline. These data support the hypothesis that nitric oxide has important roles in the regulation of adrenal blood flow and adrenal corticomedullary functions during normoxaemia and hypoxaemia functions in the late gestation llama fetus. PMID:12356897

Asymmetric Flow Field Flow Fractionation of Aqueous C60 Nanoparticles with Size Determination by Dynamic Light Scattering and Quantification by Liquid Chromatography Atmospheric Pressure Photo-Ionization Mass Spectrometry

EPA Science Inventory

A size separation method was developed for aqueous C60 fullerene aggregates (aqu/C60) using asymmetric flow field flow fractionation (AF4) coupled to a dynamic light scattering detector in flow through mode. Surfactants, which are commonly used in AF4, were avoided as they may al...

Measurement of oxygen tension in the ischemic myocardium using encased polargraphic oxygen electrodes.

PubMed

Barrett, J A; Lynch, V D; Balkon, J; Wolf, P S

1986-06-01

The ability to continuously monitor the delicate balance between blood flow and oxygen consumption would be a great asset in the study of myocardial ischemia. The present study was performed, in anesthetized dogs, to validate the use of encased polargraphic oxygen electrodes in the study of myocardial ischemia. Polargraphic oxygen electrodes were placed in the area to be rendered ischemic at fixed tissue depths of 3 mm (epicardium) and 9 mm (endocardium). Endocardial and epicardial oxygen tensions as well as the ratio of endocardial to epicardial oxygen tension and left circumflex coronary flow were monitored. Ischemia was induced by decreasing left circumflex coronary flow by 50%. Upon completion of a 20-min poststenotic period, endocardial pO2, endocardial/epicardial ratio, and coronary flow were significantly decreased (59 +/- 7, 52 +/- 7, and 55 +/- 4%, respectively) whereas epicardial pO2 was slightly decreased. Nitroglycerin (10 micrograms/kg, i.v.) markedly increased endocardial pO2 and endocardial/epicardial ratio above poststenotic control (13 +/- 5 mmHg and 64 +/- 10%, respectively) whereas epicardial pO2 was not significantly decreased. The increases in endocardial pO2 occurred at a point where coronary flow and mean arterial pressure were not significantly changed. Conversely, dipyridamole (125 micrograms/kg, i.v.) significantly increased coronary flow (26 +/- 2 ml/min/100 g) although it did not appreciably alter endocardial or epicardial pO2. It is concluded that encased polargraphic oxygen electrodes provide a quantitative method for determination of oxygen tension in the ischemic myocardium.

Numerical investigation of turbulent channel flow

NASA Technical Reports Server (NTRS)

Moin, P.; Kim, J.

1981-01-01

Fully developed turbulent channel flow was simulated numerically at Reynolds number 13800, based on centerline velocity and channel halt width. The large-scale flow field was obtained by directly integrating the filtered, three dimensional, time dependent, Navier-Stokes equations. The small-scale field motions were simulated through an eddy viscosity model. The calculations were carried out on the ILLIAC IV computer with up to 516,096 grid points. The computed flow field was used to study the statistical properties of the flow as well as its time dependent features. The agreement of the computed mean velocity profile, turbulence statistics, and detailed flow structures with experimental data is good. The resolvable portion of the statistical correlations appearing in the Reynolds stress equations are calculated. Particular attention is given to the examination of the flow structure in the vicinity of the wall.

Internal variability of a dynamically downscaled climate over North America

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Jiali; Bessac, Julie; Kotamarthi, Rao

This study investigates the internal variability (IV) of a regional climate model, and considers the impacts of horizontal resolution and spectral nudging on the IV. A 16-member simulation ensemble was conducted using the Weather Research Forecasting model for three model configurations. Ensemble members included simulations at spatial resolutions of 50 km and 12 km without spectral nudging and simulations at a spatial resolution of 12 km with spectral nudging. All the simulations were generated over the same domain, which covered much of North America. The degree of IV was measured as the spread between the individual members of the ensemblemore » during the integration period. The IV of the 12 km simulation with spectral nudging was also compared with a future climate change simulation projected by the same model configuration. The variables investigated focus on precipitation and near-surface air temperature. While the IVs show a clear annual cycle with larger values in summer and smaller values in winter, the seasonal IV is smaller for a 50-km spatial resolution than for a 12-km resolution when nudging is not applied. Applying a nudging technique to the 12-km simulation reduces the IV by a factor of two, and produces smaller IV than the simulation at 50 km without nudging. Applying a nudging technique also changes the geographic distributions of IV in all examined variables. The IV is much smaller than the inter-annual variability at seasonal scales for regionally averaged temperature and precipitation. The IV is also smaller than the projected changes in air-temperature for the mid- and late 21st century. However, the IV is larger than the projected changes in precipitation for the mid- and late 21st century.« less

Internal variability of a dynamically downscaled climate over North America

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Jiali; Bessac, Julie; Kotamarthi, Rao

This study investigates the internal variability (IV) of a regional climate model, and considers the impacts of horizontal resolution and spectral nudging on the IV. A 16-member simulation ensemble was conducted using the Weather Research Forecasting model for three model configurations. Ensemble members included simulations at spatial resolutions of 50 and 12 km without spectral nudging and simulations at a spatial resolution of 12 km with spectral nudging. All the simulations were generated over the same domain, which covered much of North America. The degree of IV was measured as the spread between the individual members of the ensemble duringmore » the integration period. The IV of the 12 km simulation with spectral nudging was also compared with a future climate change simulation projected by the same model configuration. The variables investigated focus on precipitation and near-surface air temperature. While the IVs show a clear annual cycle with larger values in summer and smaller values in winter, the seasonal IV is smaller for a 50-km spatial resolution than for a 12-km resolution when nudging is not applied. Applying a nudging technique to the 12-km simulation reduces the IV by a factor of two, and produces smaller IV than the simulation at 50 km without nudging. Applying a nudging technique also changes the geographic distributions of IV in all examined variables. The IV is much smaller than the inter-annual variability at seasonal scales for regionally averaged temperature and precipitation. The IV is also smaller than the projected changes in air-temperature for the mid- and late twenty-first century. However, the IV is larger than the projected changes in precipitation for the mid- and late twenty-first century.« less

Internal variability of a dynamically downscaled climate over North America

NASA Astrophysics Data System (ADS)

Wang, Jiali; Bessac, Julie; Kotamarthi, Rao; Constantinescu, Emil; Drewniak, Beth

2018-06-01

This study investigates the internal variability (IV) of a regional climate model, and considers the impacts of horizontal resolution and spectral nudging on the IV. A 16-member simulation ensemble was conducted using the Weather Research Forecasting model for three model configurations. Ensemble members included simulations at spatial resolutions of 50 and 12 km without spectral nudging and simulations at a spatial resolution of 12 km with spectral nudging. All the simulations were generated over the same domain, which covered much of North America. The degree of IV was measured as the spread between the individual members of the ensemble during the integration period. The IV of the 12 km simulation with spectral nudging was also compared with a future climate change simulation projected by the same model configuration. The variables investigated focus on precipitation and near-surface air temperature. While the IVs show a clear annual cycle with larger values in summer and smaller values in winter, the seasonal IV is smaller for a 50-km spatial resolution than for a 12-km resolution when nudging is not applied. Applying a nudging technique to the 12-km simulation reduces the IV by a factor of two, and produces smaller IV than the simulation at 50 km without nudging. Applying a nudging technique also changes the geographic distributions of IV in all examined variables. The IV is much smaller than the inter-annual variability at seasonal scales for regionally averaged temperature and precipitation. The IV is also smaller than the projected changes in air-temperature for the mid- and late twenty-first century. However, the IV is larger than the projected changes in precipitation for the mid- and late twenty-first century.

Internal variability of a dynamically downscaled climate over North America

NASA Astrophysics Data System (ADS)

Wang, Jiali; Bessac, Julie; Kotamarthi, Rao; Constantinescu, Emil; Drewniak, Beth

2017-09-01

This study investigates the internal variability (IV) of a regional climate model, and considers the impacts of horizontal resolution and spectral nudging on the IV. A 16-member simulation ensemble was conducted using the Weather Research Forecasting model for three model configurations. Ensemble members included simulations at spatial resolutions of 50 and 12 km without spectral nudging and simulations at a spatial resolution of 12 km with spectral nudging. All the simulations were generated over the same domain, which covered much of North America. The degree of IV was measured as the spread between the individual members of the ensemble during the integration period. The IV of the 12 km simulation with spectral nudging was also compared with a future climate change simulation projected by the same model configuration. The variables investigated focus on precipitation and near-surface air temperature. While the IVs show a clear annual cycle with larger values in summer and smaller values in winter, the seasonal IV is smaller for a 50-km spatial resolution than for a 12-km resolution when nudging is not applied. Applying a nudging technique to the 12-km simulation reduces the IV by a factor of two, and produces smaller IV than the simulation at 50 km without nudging. Applying a nudging technique also changes the geographic distributions of IV in all examined variables. The IV is much smaller than the inter-annual variability at seasonal scales for regionally averaged temperature and precipitation. The IV is also smaller than the projected changes in air-temperature for the mid- and late twenty-first century. However, the IV is larger than the projected changes in precipitation for the mid- and late twenty-first century.

Two-dimensional fluid dynamics in a sharply bent channel: Laminar flow, separation bubble, and vortex dynamics

NASA Astrophysics Data System (ADS)

Matsumoto, Daichi; Fukudome, Koji; Wada, Hirofumi

2016-10-01

Understanding the hydrodynamic properties of fluid flow in a curving pipe and channel is important for controlling the flow behavior in technologies and biomechanics. The nature of the resulting flow in a bent pipe is extremely complicated because of the presence of a cross-stream secondary flow. In an attempt to disentangle this complexity, we investigate the fluid dynamics in a bent channel via the direct numerical simulation of the Navier-Stokes equation in two spatial dimensions. We exploit the absence of secondary flow from our model and systematically investigate the flow structure along the channel as a function of both the bend angle and Reynolds number of the laminar-to-turbulent regime. We numerically suggest a scaling relation between the shape of the separation bubble and the flow conductance, and construct an integrated phase diagram.

Noise and Chaos in Driven Josephson Junctions

DTIC Science & Technology

1987-03-01

be physically close to some noisy equipment such as a CO2 laser containing an electric discharge and the laser power supply . So we have to try to...regions. The agreement is very good in some of the quanti- tative comparisons such as the step width dependence on the laser power . The simulations...discovered that the noisy I-V curves are caused I various nonlinear dynamic effects. There are I-V curves irradiated at certain laser power levels

Effects of intraosseous epinephrine in a cardiac arrest swine model.

PubMed

Wong, Marc R; Reggio, Matt J; Morocho, Freddy R; Holloway, Monica M; Garcia-Blanco, Jose C; Jenkins, Constance; Johnson, Arthur D

2016-04-01

Interruptions in cardiopulmonary resuscitation (CPR) to obtain vascular access reduces blood flow to vital organs. Tibial intraosseous (TIO) access may be a faster alternative to intravenous (IV) access for delivery of vasoactive medications. The purpose of this study was to examine the differences in pharmacokinetics and pharmacodynamics of TIO- and IV-delivered epinephrine. A prospective, between subjects, experimental design comparing Cmax, Tmax, return of spontaneous circulation (ROSC), and time to ROSC. Adult male swine were divided into three equal groups (n = 7) all received CPR and defibrillation: the second group received IV epinephrine and the third group received tibial intraosseous epinephrine. Swine were placed in cardiac arrest for 2 min before CPR was initiated. After 2 min of CPR, epinephrine was delivered by IV or TIO, and serial blood samples were collected over 4 min. There were no significant differences between IV versus TIO epinephrine in achieving ROSC, time to ROSC, and Cmax. A one-way analysis of variance demonstrated a significant difference between the IV and TIO groups in Tmax (P = 0.025). A Fisher exact test demonstrated a significant difference between IV epinephrine versus CPR/Defib only (P = 0.035) and TIO epinephrine versus CPR/Defib only (P = 0.010) in achieving ROSC. A multivariate analysis of variance showed significant differences in IV versus intraosseous epinephrine concentration at specific time intervals: 60 (P = 0.023), 90 (P = 0.001), and 120 (P < 0.000) sec. In the context of ROSC, epinephrine delivered via TIO route is a clinically relevant alternative to IV administration. When IV access cannot be immediately obtained in cardiac arrest patients, TIO access should be considered. Published by Elsevier Inc.

Expanding AirSTAR Capability for Flight Research in an Existing Avionics Design

NASA Technical Reports Server (NTRS)

Laughter, Sean A.

2012-01-01

The NASA Airborne Subscale Transport Aircraft Research (AirSTAR) project is an Unmanned Aerial Systems (UAS) test bed for experimental flight control laws and vehicle dynamics research. During its development, the test bed has gone through a number of system permutations, each meant to add functionality to the concept of operations of the system. This enabled the build-up of not only the system itself, but also the support infrastructure and processes necessary to support flight operations. These permutations were grouped into project phases and the move from Phase-III to Phase-IV was marked by a significant increase in research capability and necessary safety systems due to the integration of an Internal Pilot into the control system chain already established for the External Pilot. The major system changes in Phase-IV operations necessitated a new safety and failsafe system to properly integrate both the Internal and External Pilots and to meet acceptable project safety margins. This work involved retrofitting an existing data system into the evolved concept of operations. Moving from the first Phase-IV aircraft to the dynamically scaled aircraft further involved restructuring the system to better guard against electromagnetic interference (EMI), and the entire avionics wiring harness was redesigned in order to facilitate better maintenance and access to onboard electronics. This retrofit and harness re-design will be explored and how it integrates with the evolved Phase-IV operations.

Dynamic interaction of two-phase debris flow with pyramidal defense structures: An optimal strategy to efficiently protecting the desired area

NASA Astrophysics Data System (ADS)

Kattel, Parameshwari; Kafle, Jeevan; Fischer, Jan-Thomas; Mergili, Martin; Tuladhar, Bhadra Man; Pudasaini, Shiva P.

2017-04-01

In this work we analyze the dynamic interaction of two phase debris flows with pyramidal obstacles. To simulate the dynamic interaction of two-phase debris flow (a mixture of solid particles and viscous fluid) with obstacles of different dimensions and orientations, we employ the general two-phase mass flow model (Pudasaini, 2012). The model consists of highly non-linear partial differential equations representing the mass and momentum conservations for both solid and fluid. Besides buoyancy, the model includes some dominant physical aspects of the debris flows such as generalized drag, virtual mass and non-Newtonian viscous stress as induced by the gradient of solid-volume-fraction. Simulations are performed with high-resolution numerical schemes to capture essential dynamics, including the strongly re-directed flow with multiple stream lines, mass arrest and debris-vacuum generation when the rapidly cascading debris mass suddenly encounters the obstacle. The solid and fluid phases show fundamentally different interactions with obstacles, flow spreading and dispersions, run-out dynamics, and deposition morphology. A forward-facing pyramid deflects the mass wider, and a rearward-facing pyramid arrests a portion of solid-mass at its front. Our basic study reveals that appropriately installed obstacles, their dimensions and orientations have a significant influence on the flow dynamics, material redistribution and redirection. The precise knowledge of the change in dynamics is of great importance for the optimal and effective protection of designated areas along the mountain slopes and the runout zones. Further important results are, that specific installations lead to redirect either solid, or fluid, or both, in the desired amounts and directions. The present method of the complex interactions of real two-phase mass flows with the obstacles may help us to construct defense structures and to design advanced and physics-based engineering solutions for the prevention and mitigation of natural hazards caused by geophysical mass flows. References: Pudasaini, S. P. (2012): A general two-phase debris flow model. J. Geophys. Res. 117, F03010, doi: 10.1029/ 2011JF002186.

Trade-off Assessment of Simplified Routing Models for Short-Term Hydropower Reservoir Optimization

NASA Astrophysics Data System (ADS)

Issao Kuwajima, Julio; Schwanenberg, Dirk; Alvardo Montero, Rodolfo; Mainardi Fan, Fernando; Assis dos Reis, Alberto

2014-05-01

Short-term reservoir optimization, also referred to as model predictive control, integrates model-based forecasts and optimization algorithms to meet multiple management objectives such as water supply, navigation, hydroelectricity generation, environmental obligations and flood protection. It is a valuable decision support tool to handle water-stress conditions or flooding events, and supports decision makers to minimize their impact. If the reservoir management includes downstream control, for example for mitigation flood damages in inundation areas downstream of the operated dam, the flow routing between the dam and the downstream inundation area is of major importance. The unsteady open channel flow in river reaches can be described by the one-dimensional Saint-Venant equations. However, owing to the mathematical complexity of those equations, some simplifications may be required to speed up the computation within the optimization procedure. Another strategy to limit the model runtime is a schematization on a course computational grid. In particular the last measure can introduce significant numerical diffusion into the solution. This is a major drawback, in particular if the reservoir release has steep gradients which we often find in hydropower reservoirs. In this work, four different routing models are assessed concerning their implementation in the predictive control of the Três Marias Reservoir located at the Upper River São Francisco in Brazil: i) a fully dynamic model using the software package SOBEK; ii) a semi-distributed rainfall-runoff model with Muskingum-Cunge routing for the flow reaches of interest, the MGB-IPH (Modelo Hidrológico de Grandes Bacias - Instituto de Pesquisas Hidráulicas); iii) a reservoir routing approach; and iv) a diffusive wave model. The last two models are implemented in the RTC-Tool toolbox. The overall model accuracy between the simplified models in RTC-Tools (iii, iv) and the more sophisticated SOBEK model (i) are comparable, and a lower performance was assessed for the MGB model (ii). Whereas the SOBEK model is able to propagate sharp discharge gradient downstream, the diffusive wave model is damping these gradients significantly due to the course spatial schematization. In the reservoir routing model, which is also schematized on a course grid, we counteract this drawback by modeling parts of the river reach by advection. This results in an excellent ratio between model accuracy / robustness and computational effort making it the approach of choice from the predictive control perspective.

Vasopressin attenuates TNF-mediated inflammation in the rat cremaster microcirculation.

PubMed

McMahon, Paul J; Proctor, Kenneth G

2009-09-01

Our previous study in a swine polytrauma model suggested that equieffective systemic pressor doses of arginine vasopressin (AVP) versus phenylephrine (PE) have differential effects on the systemic and cerebral microcirculation. The purpose of this study was to directly observe the effects of AVP versus PE on inflammatory changes evoked by tumor necrosis factor alpha (TNF) in the skeletal muscle microcirculation. Seventy-five male rats (180-250 g) were anesthetized with isoforane, intubated and mechanically ventilated with 100% oxygen. The cremaster muscle microcirculation was prepared for intravital video microscopy while being suffused with a heated hetastarch-electrolyte solution. Fluorescein isothiocyanate-labeled albumin (100 mg/kg) was administered intravenously (i.v.) before one of five protocols. In series 1 (n = 20), either AVP (0.2 U/mL) or its vehicle was added to the suffusate for 10 minutes, washed out for 30 minutes, then TNF was suffused (5 ng/mL) for 30 minutes. In series 2 (n = 16), the protocol was similar, except AVP (0.2 U/mL) or an equieffective dose of PE (0.04 mg/mL) was administered i.v. (4.5 mL/h) for 15 minutes before, during, and 45 minutes after TNF suffusion. In series 3 (n = 12), the protocol was similar to series 2, except venous hemorrhage preceded i.v. AVP or PE. In series 4 (n = 15), the protocol was similar to series 3, except an AVP antagonist (vaprisol, 1 mg/kg i.v.) or its vehicle was administered after hemorrhage. In the control series (n = 13), inflammation was evaluated either with a different suffusate (lactated Ringers instead of hetastarch solution), different antigen (histamine instead of TNF), or hemorrhage with no antigen. In series 1, the TNF-evoked increase in leukocyte infiltration (i.e., rolling), leukocyte activation (i.e., sticking), and macromolecular permeability (i.e., albumin extravasation) were attenuated with topical AVP versus vehicle (both p < 0.05), with no effect on venular blood flow (which determines sheer stress). In series 2, the TNF-evoked increase in infiltration, activation, and permeability were all attenuated, and arteriolar blood flow (which determines perfused capillary surface area and hydrostatic pressure) was reduced with i.v. AVP versus i.v. PE (all p < 0.05). In series 3, after hemorrhage to mean arterial pressure <50 mm Hg for 30 minutes, the TNF-evoked increase in infiltration and activation was attenuated, and arteriolar and venular blood flow were both reduced with i.v. AVP versus PE (all p < 0.05). In series 4, after hemorrhage, the TNF-evoked increase in leukocyte activation was potentiated with the vaprisol versus vehicle (p < 0.05) with no effect on arteriolar or venular blood flow. In series 5 (controls), suffusion with lactated Ringers' versus hetastarch solution more than doubled the TNF-evoked increase in activation (p < 0.05). (1) AVP can attenuate TNF-evoked leukocyte infiltration, activation or permeability changes in the skeletal muscle microcirculation. (2) The mechanism is probably receptor mediated and does not entirely depend on sheer stress in venules or Starling forces in capillaries. (3) The magnitude of this anti-inflammatory effect is influenced by several conditions, including volume status, the colloid or crystalloid suffusion fluid, and is possibly specific to the antigenic stimulus (TNF vs. histamine).

Quantification and Control of Wall Effects in Porous Media Experiments

NASA Astrophysics Data System (ADS)

Roth, E. J.; Mays, D. C.; Neupauer, R.; Crimaldi, J. P.

2017-12-01

Fluid flow dynamics in porous media are dominated by media heterogeneity. This heterogeneity can create preferential pathways in which local seepage velocities dwarf system seepage velocities, further complicating an already incomplete understanding of dispersive processes. In physical models of porous media flows, apparatus walls introduce preferential flow paths (i.e., wall effects) that may overwhelm other naturally occurring preferential pathways within the apparatus, leading to deceptive results. We used planar laser-induced fluorescence (PLIF) in conjunction with refractive index matched (RIM) porous media and pore fluid to observe fluid dynamics in the porous media, with particular attention to the region near the apparatus walls in a 17 cm x 8 cm x 7 cm uniform flow cell. Hexagonal close packed spheres were used to create an isotropic, homogenous porous media field in the interior of the apparatus. Visualization of the movement of a fluorescent dye revealed the influence of the wall in creating higher permeability preferential flow paths in an otherwise homogenous media packing. These preferential flow paths extended approximately one half of one sphere diameter from the wall for homogenously packed regions, with a quickly diminishing effect on flow dynamics for homogenous media adjacent to the preferential pathway, but with major influence on flow dynamics for adjoining heterogeneous regions. Multiple approaches to mitigate wall effects were investigated, and a modified wall was created such that the fluid dynamics near the wall mimics the fluid dynamics within the homogenous porous media. This research supports the design of a two-dimensional experimental apparatus that will simulate engineered pumping schemes for use in contaminant remediation. However, this research could benefit the design of fixed bed reactors or other engineering challenges in which vessel walls contribute to unwanted preferential flow.

Imaging and modeling of flow in porous media using clinical nuclear emission tomography systems and computational fluid dynamics

NASA Astrophysics Data System (ADS)

Boutchko, Rostyslav; Rayz, Vitaliy L.; Vandehey, Nicholas T.; O'Neil, James P.; Budinger, Thomas F.; Nico, Peter S.; Druhan, Jennifer L.; Saloner, David A.; Gullberg, Grant T.; Moses, William W.

2012-01-01

This paper presents experimental and modeling aspects of applying nuclear emission tomography to study fluid flow in laboratory packed porous media columns of the type frequently used in geophysics, geochemistry and hydrology research. Positron emission tomography (PET) and single photon emission computed tomography (SPECT) are used as non-invasive tools to obtain dynamic 3D images of radioactive tracer concentrations. Dynamic sequences obtained using 18F-FDG PET are used to trace flow through a 5 cm diameter × 20 cm tall sand packed column with and without an impermeable obstacle. In addition, a custom-made rotating column setup placed in a clinical two-headed SPECT camera is used to image 99mTc-DTPA tracer propagation in a through-flowing column (10 cm diameter × 30 cm tall) packed with recovered aquifer sediments. A computational fluid dynamics software package FLUENT is used to model the observed flow dynamics. Tracer distributions obtained in the simulations in the smaller column uniformly packed with sand and in the column with an obstacle are remarkably similar to the reconstructed images in the PET experiments. SPECT results demonstrate strongly non-uniform flow patterns for the larger column slurry-packed with sub-surface sediment and slow upward flow. In the numerical simulation of the SPECT study, two symmetric channels with increased permeability are prescribed along the column walls, which result in the emergence of two well-defined preferential flow paths. Methods and results of this work provide new opportunities in hydrologic and biogeochemical research. The primary target application for developed technologies is non-destructive, non-perturbing, quantitative imaging of flow dynamics within laboratory scale porous media systems.

Imaging and modeling of flow in porous media using clinical nuclear emission tomography systems and computational fluid dynamics.

PubMed

Boutchko, Rostyslav; Rayz, Vitaliy L; Vandehey, Nicholas T; O'Neil, James P; Budinger, Thomas F; Nico, Peter S; Druhan, Jennifer L; Saloner, David A; Gullberg, Grant T; Moses, William W

2012-01-01

This paper presents experimental and modeling aspects of applying nuclear emission tomography to study fluid flow in laboratory packed porous media columns of the type frequently used in geophysics, geochemistry and hydrology research. Positron emission tomography (PET) and single photon emission computed tomography (SPECT) are used as non-invasive tools to obtain dynamic 3D images of radioactive tracer concentrations. Dynamic sequences obtained using 18 F-FDG PET are used to trace flow through a 5 cm diameter × 20 cm tall sand packed column with and without an impermeable obstacle. In addition, a custom-made rotating column setup placed in a clinical two-headed SPECT camera is used to image 99m Tc-DTPA tracer propagation in a through-flowing column (10 cm diameter × 30 cm tall) packed with recovered aquifer sediments. A computational fluid dynamics software package FLUENT is used to model the observed flow dynamics. Tracer distributions obtained in the simulations in the smaller column uniformly packed with sand and in the column with an obstacle are remarkably similar to the reconstructed images in the PET experiments. SPECT results demonstrate strongly non-uniform flow patterns for the larger column slurry-packed with sub-surface sediment and slow upward flow. In the numerical simulation of the SPECT study, two symmetric channels with increased permeability are prescribed along the column walls, which result in the emergence of two well-defined preferential flow paths. Methods and results of this work provide new opportunities in hydrologic and biogeochemical research. The primary target application for developed technologies is non-destructive, non-perturbing, quantitative imaging of flow dynamics within laboratory scale porous media systems.

SIVEH: numerical computing simulation of wireless energy-harvesting sensor nodes.

PubMed

Sanchez, Antonio; Blanc, Sara; Climent, Salvador; Yuste, Pedro; Ors, Rafael

2013-09-04

The paper presents a numerical energy harvesting model for sensor nodes, SIVEH (Simulator I-V for EH), based on I-V hardware tracking. I-V tracking is demonstrated to be more accurate than traditional energy modeling techniques when some of the components present different power dissipation at either different operating voltages or drawn currents. SIVEH numerical computing allows fast simulation of long periods of time-days, weeks, months or years-using real solar radiation curves. Moreover, SIVEH modeling has been enhanced with sleep time rate dynamic adjustment, while seeking energy-neutral operation. This paper presents the model description, a functional verification and a critical comparison with the classic energy approach.

On the impact of atmospheric thermal stability on the characteristics of nocturnal downslope flows

NASA Astrophysics Data System (ADS)

Ye, Z. J.; Garratt, J. R.; Segal, M.; Pielke, R. A.

1990-04-01

The impacts of background (or ambient) and local atmospheric thermal stabilities, and slope steepness, on nighttime thermally induced downslope flow in meso-β domains (i.e., 20 200 km horizontal extent) have been investigated using analytical and numerical model approaches. Good agreement between the analytical and numerical evaluations was found. It was concluded that: (i) as anticipated, the intensity of the downslope flow increases with increased slope steepness, although the depth of the downslope flow was found to be insensitive to slope steepness in the studied situations; (ii) the intensity of the downslope flow is generally independent of background atmospheric thermal stability; (iii) for given integrated nighttime cooling across the nocturnal boundary layer (NBL), Q s the local atmospheric thermal stability exerts a strong influence on downslope flow behavior: the downslope flow intensity increases when local atmospheric thermal stability increases; and (iv) the downslope flow intensity is proportional to Q s 1/2.

Unified Kinetic Approach for Simulation of Gas Flows in Rarefied and Continuum Regimes

DTIC Science & Technology

2007-06-01

potential , iii) the Lennard - Jones potential , iv) the Coulomb potential , and v) the BGK model. For 2D simulations, the BGK model was implemented in a...were performed for the Lennard - Jones interaction potential . The agreement of experimental and calculated profiles indicates the high accuracy of the...calculations by two potentials (Hard Spheres and Lennard - Jones ) demonstrated similar behavior of the main quantities. The flow field structures are quite

Unsteady Specific Work and Isentropic Efficiency of a Radial Turbine Driven by Pulsed Detonations

DTIC Science & Technology

2012-06-14

iv AFIT/DS/ENY/12-25 Abstract There has been longstanding government and industry interest in pressure-gain combustion for use in Brayton cycle...10 III.A. Unsteady Flow in Conventional Brayton Cycle Turbines ........................10 III.B. Unsteady Flow in Pulsed Detonation Driven...Szpynda and Nalim 2007) 114 Figure 69. Heiser and Pratt comparison of ideal PDE, Humphrey, and Brayton cycles on a temperature-entropy diagram (Heiser

Production version of the extended NASA-Langley Vortex Lattice FORTRAN computer program. Volume 1: User's guide

NASA Technical Reports Server (NTRS)

Lamar, J. E.; Herbert, H. E.

1982-01-01

The latest production version, MARK IV, of the NASA-Langley vortex lattice computer program is summarized. All viable subcritical aerodynamic features of previous versions were retained. This version extends the previously documented program capabilities to four planforms, 400 panels, and enables the user to obtain vortex-flow aerodynamics on cambered planforms, flowfield properties off the configuration in attached flow, and planform longitudinal load distributions.

Investigations of the role of nonlinear couplings in structure formation and transport regulation in plasma turbulence

NASA Astrophysics Data System (ADS)

Holland, Christopher George

Studies of nonlinear couplings and dynamics in plasma turbulence are presented. Particular areas of focus are analytic studies of coherent structure formation in electron temperature gradient turbulence, measurement of nonlinear energy transfer in simulations of plasma turbulence, and bispectral analysis of experimental and computational data. The motivation for these works has been to develop and expand the existing theories of plasma transport, and verify the nonlinear predictions of those theories in simulation and experiment. In Chapter II, we study electromagnetic secondary instabilities of electron temperature gradient turbulence. The growth rate for zonal flow generation via modulational instability of electromagnetic ETG turbulence is calculated, as well as that for zonal (magnetic) field generation. In Chapter III, the stability and saturation of streamers in ETG turbulence is considered, and shown to depend sensitively upon geometry and the damping rates of the Kelvin-Helmholtz mode. Requirements for a credible theory of streamer transport are presented. In addition, a self-consistent model for interactions between ETG and ITG (ion temperature gradient) turbulence is presented. In Chapter IV, the nonlinear transfer of kinetic and internal energy is measured in simulations of plasma turbulence. The regulation of turbulence by radial decorrelation due to zonal flows and generation of zonal flows via the Reynolds stress are explicitly demonstrated, and shown to be symmetric facets of a single nonlinear process. Novel nonlinear saturation mechanisms for zonal flows are discussed. In Chapter V, measurements of fluctuation bicoherence in the edge of the DIII-D tokamak are presented. It is shown that the bicoherence increases transiently before a L-H transition, and decays to its initial value after the barrier has formed. The increase in bicoherence is localized to the region where the transport barrier forms, and shows strong coupling between well-separated frequencies. These results are qualitatively reproduced in a simple numerical "thought experiment," described in Chapter VI, which suggests that zonal flows may trigger the L-H transition.

Heavy and Thermal Oil Recovery Production Mechanisms, SUPRI TR-127

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kovscek, Anthony R.; Brigham, William E.; Castanier, Louis M.

The program spans a spectrum of topics and is divided into five categories: (i) multiphase flow and rock properties, (ii) hot fluid injection, (iii) primary heavy-oil production, (iv) reservoir definition, and (v) in-situ combustion.

Reduction of gas flow nonuniformity in gas turbine engines by means of gas-dynamic methods

NASA Astrophysics Data System (ADS)

Matveev, V.; Baturin, O.; Kolmakova, D.; Popov, G.

2017-08-01

Gas flow nonuniformity is one of the main sources of rotor blade vibrations in the gas turbine engines. Usually, the flow circumferential nonuniformity occurs near the annular frames, located in the flow channel of the engine. This leads to the increased dynamic stresses in blades and as a consequence to the blade damage. The goal of the research was to find an acceptable method of reducing the level of gas flow nonuniformity as the source of dynamic stresses in the rotor blades. Two different methods were investigated during this research. Thus, this study gives the ideas about methods of improving the flow structure in gas turbine engine. On the basis of existing conditions (under development or existing engine) it allows the selection of the most suitable method for reducing gas flow nonuniformity.

Effect of Air Swirler Configuration on Lean Direct Injector Flow Structure and Combustion Performance with a 7-Point Lean Direct Injector Array

NASA Technical Reports Server (NTRS)

Hicks, Yolanda R.; Tacina, Kathleen M.; Anderson, Robert C.

2017-01-01

Studies of various injector configurations in a 7-point Lean Direct Injector (LDI) array are reported for both non-reacting (cold) flow and for Jet-A/air reacting flows. For cold flow, central recirculation zone (CRZ) formation is investigated and for reacting flows, combustor operability and dynamics are of interest. 2D Particle Image Velocimetry (PIV) measurements are described for the cold flow experiments and flame chemiluminescence imaging and dynamic pressure results are discussed for the reacting flow cases. PIV results indicate that for this configuration the close spacing between swirler elements leads to strong interaction that affects whether a CRZ forms, and pilot recess and counter-swirl helps to isolate swirlers from one another. Dynamics results focus on features identified near 500-Hz.

Low dose dynamic myocardial CT perfusion using advanced iterative reconstruction

NASA Astrophysics Data System (ADS)

Eck, Brendan L.; Fahmi, Rachid; Fuqua, Christopher; Vembar, Mani; Dhanantwari, Amar; Bezerra, Hiram G.; Wilson, David L.

2015-03-01

Dynamic myocardial CT perfusion (CTP) can provide quantitative functional information for the assessment of coronary artery disease. However, x-ray dose in dynamic CTP is high, typically from 10mSv to >20mSv. We compared the dose reduction potential of advanced iterative reconstruction, Iterative Model Reconstruction (IMR, Philips Healthcare, Cleveland, Ohio) to hybrid iterative reconstruction (iDose4) and filtered back projection (FBP). Dynamic CTP scans were obtained using a porcine model with balloon-induced ischemia in the left anterior descending coronary artery to prescribed fractional flow reserve values. High dose dynamic CTP scans were acquired at 100kVp/100mAs with effective dose of 23mSv. Low dose scans at 75mAs, 50mAs, and 25mAs were simulated by adding x-ray quantum noise and detector electronic noise to the projection space data. Images were reconstructed with FBP, iDose4, and IMR at each dose level. Image quality in static CTP images was assessed by SNR and CNR. Blood flow was obtained using a dynamic CTP analysis pipeline and blood flow image quality was assessed using flow-SNR and flow-CNR. IMR showed highest static image quality according to SNR and CNR. Blood flow in FBP was increasingly over-estimated at reduced dose. Flow was more consistent for iDose4 from 100mAs to 50mAs, but was over-estimated at 25mAs. IMR was most consistent from 100mAs to 25mAs. Static images and flow maps for 100mAs FBP, 50mAs iDose4, and 25mAs IMR showed comparable, clear ischemia, CNR, and flow-CNR values. These results suggest that IMR can enable dynamic CTP at significantly reduced dose, at 5.8mSv or 25% of the comparable 23mSv FBP protocol.

Dynamic Transitions and Baroclinic Instability for 3D Continuously Stratified Boussinesq Flows

NASA Astrophysics Data System (ADS)

Şengül, Taylan; Wang, Shouhong

2018-02-01

The main objective of this article is to study the nonlinear stability and dynamic transitions of the basic (zonal) shear flows for the three-dimensional continuously stratified rotating Boussinesq model. The model equations are fundamental equations in geophysical fluid dynamics, and dynamics associated with their basic zonal shear flows play a crucial role in understanding many important geophysical fluid dynamical processes, such as the meridional overturning oceanic circulation and the geophysical baroclinic instability. In this paper, first we derive a threshold for the energy stability of the basic shear flow, and obtain a criterion for local nonlinear stability in terms of the critical horizontal wavenumbers and the system parameters such as the Froude number, the Rossby number, the Prandtl number and the strength of the shear flow. Next, we demonstrate that the system always undergoes a dynamic transition from the basic shear flow to either a spatiotemporal oscillatory pattern or circle of steady states, as the shear strength of the basic flow crosses a critical threshold. Also, we show that the dynamic transition can be either continuous or catastrophic, and is dictated by the sign of a transition number, fully characterizing the nonlinear interactions of different modes. Both the critical shear strength and the transition number are functions of the system parameters. A systematic numerical method is carried out to explore transition in different flow parameter regimes. In particular, our numerical investigations show the existence of a hypersurface which separates the parameter space into regions where the basic shear flow is stable and unstable. Numerical investigations also yield that the selection of horizontal wave indices is determined only by the aspect ratio of the box. We find that the system admits only critical eigenmodes with roll patterns aligned with the x-axis. Furthermore, numerically we encountered continuous transitions to multiple steady states, as well as continuous and catastrophic transitions to spatiotemporal oscillations.

Dynamic Succession of Groundwater Functional Microbial Communities in Response to Emulsified Vegetable Oil Amendment during Sustained In Situ U(VI) Reduction.

PubMed

Zhang, Ping; Wu, Wei-Min; Van Nostrand, Joy D; Deng, Ye; He, Zhili; Gihring, Thomas; Zhang, Gengxin; Schadt, Chris W; Watson, David; Jardine, Phil; Criddle, Craig S; Brooks, Scott; Marsh, Terence L; Tiedje, James M; Arkin, Adam P; Zhou, Jizhong

2015-06-15

A pilot-scale field experiment demonstrated that a one-time amendment of emulsified vegetable oil (EVO) reduced groundwater U(VI) concentrations for 1 year in a fast-flowing aquifer. However, little is known about how EVO amendment stimulates the functional gene composition, structure, and dynamics of groundwater microbial communities toward prolonged U(VI) reduction. In this study, we hypothesized that EVO amendment would shift the functional gene composition and structure of groundwater microbial communities and stimulate key functional genes/groups involved in EVO biodegradation and reduction of electron acceptors in the aquifer. To test these hypotheses, groundwater microbial communities after EVO amendment were analyzed using a comprehensive functional gene microarray. Our results showed that EVO amendment stimulated sequential shifts in the functional composition and structure of groundwater microbial communities. Particularly, the relative abundance of key functional genes/groups involved in EVO biodegradation and the reduction of NO3 (-), Mn(IV), Fe(III), U(VI), and SO4 (2-) significantly increased, especially during the active U(VI) reduction period. The relative abundance for some of these key functional genes/groups remained elevated over 9 months. Montel tests suggested that the dynamics in the abundance, composition, and structure of these key functional genes/groups were significantly correlated with groundwater concentrations of acetate, NO3 (-), Mn(II), Fe(II), U(VI), and SO4 (2-). Our results suggest that EVO amendment stimulated dynamic succession of key functional microbial communities. This study improves our understanding of the composition, structure, and function changes needed for groundwater microbial communities to sustain a long-term U(VI) reduction. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Dynamic Succession of Groundwater Functional Microbial Communities in Response to Emulsified Vegetable Oil Amendment during Sustained In Situ U(VI) Reduction

PubMed Central

Zhang, Ping; Wu, Wei-Min; Van Nostrand, Joy D.; Deng, Ye; He, Zhili; Gihring, Thomas; Zhang, Gengxin; Schadt, Chris W.; Watson, David; Jardine, Phil; Criddle, Craig S.; Brooks, Scott; Marsh, Terence L.; Tiedje, James M.; Arkin, Adam P.

2015-01-01

A pilot-scale field experiment demonstrated that a one-time amendment of emulsified vegetable oil (EVO) reduced groundwater U(VI) concentrations for 1 year in a fast-flowing aquifer. However, little is known about how EVO amendment stimulates the functional gene composition, structure, and dynamics of groundwater microbial communities toward prolonged U(VI) reduction. In this study, we hypothesized that EVO amendment would shift the functional gene composition and structure of groundwater microbial communities and stimulate key functional genes/groups involved in EVO biodegradation and reduction of electron acceptors in the aquifer. To test these hypotheses, groundwater microbial communities after EVO amendment were analyzed using a comprehensive functional gene microarray. Our results showed that EVO amendment stimulated sequential shifts in the functional composition and structure of groundwater microbial communities. Particularly, the relative abundance of key functional genes/groups involved in EVO biodegradation and the reduction of NO3−, Mn(IV), Fe(III), U(VI), and SO42− significantly increased, especially during the active U(VI) reduction period. The relative abundance for some of these key functional genes/groups remained elevated over 9 months. Montel tests suggested that the dynamics in the abundance, composition, and structure of these key functional genes/groups were significantly correlated with groundwater concentrations of acetate, NO3−, Mn(II), Fe(II), U(VI), and SO42−. Our results suggest that EVO amendment stimulated dynamic succession of key functional microbial communities. This study improves our understanding of the composition, structure, and function changes needed for groundwater microbial communities to sustain a long-term U(VI) reduction. PMID:25862231

Dynamic Succession of Groundwater Functional Microbial Communities in Response to Emulsified Vegetable Oil Amendment during Sustained In Situ U(VI) Reduction

DOE PAGES

Zhang, Ping; Wu, Wei-Min; Van Nostrand, Joy D.; ...

2015-04-10

A pilot-scale field experiment demonstrated that a one-time amendment of emulsified vegetable oil (EVO) reduced groundwater U(VI) concentrations for 1 year in a fast-flowing aquifer. However, little is known about how EVO amendment stimulates the functional gene composition, structure, and dynamics of groundwater microbial communities toward prolonged U(VI) reduction. In this paper, we hypothesized that EVO amendment would shift the functional gene composition and structure of groundwater microbial communities and stimulate key functional genes/groups involved in EVO biodegradation and reduction of electron acceptors in the aquifer. To test these hypotheses, groundwater microbial communities after EVO amendment were analyzed using amore » comprehensive functional gene microarray. Our results showed that EVO amendment stimulated sequential shifts in the functional composition and structure of groundwater microbial communities. Particularly, the relative abundance of key functional genes/groups involved in EVO biodegradation and the reduction of NO 3 -, Mn(IV), Fe(III), U(VI), and SO 4 2- significantly increased, especially during the active U(VI) reduction period. The relative abundance for some of these key functional genes/groups remained elevated over 9 months. Montel tests suggested that the dynamics in the abundance, composition, and structure of these key functional genes/groups were significantly correlated with groundwater concentrations of acetate, NO 3 -, Mn(II), Fe(II), U(VI), and SO 4 2-. Our results suggest that EVO amendment stimulated dynamic succession of key functional microbial communities. Finally, this study improves our understanding of the composition, structure, and function changes needed for groundwater microbial communities to sustain a long-term U(VI) reduction.« less

Dynamic Succession of Groundwater Functional Microbial Communities in Response to Emulsified Vegetable Oil Amendment during Sustained In Situ U(VI) Reduction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Ping; Wu, Wei-Min; Van Nostrand, Joy D.

A pilot-scale field experiment demonstrated that a one-time amendment of emulsified vegetable oil (EVO) reduced groundwater U(VI) concentrations for 1 year in a fast-flowing aquifer. However, little is known about how EVO amendment stimulates the functional gene composition, structure, and dynamics of groundwater microbial communities toward prolonged U(VI) reduction. In this paper, we hypothesized that EVO amendment would shift the functional gene composition and structure of groundwater microbial communities and stimulate key functional genes/groups involved in EVO biodegradation and reduction of electron acceptors in the aquifer. To test these hypotheses, groundwater microbial communities after EVO amendment were analyzed using amore » comprehensive functional gene microarray. Our results showed that EVO amendment stimulated sequential shifts in the functional composition and structure of groundwater microbial communities. Particularly, the relative abundance of key functional genes/groups involved in EVO biodegradation and the reduction of NO 3 -, Mn(IV), Fe(III), U(VI), and SO 4 2- significantly increased, especially during the active U(VI) reduction period. The relative abundance for some of these key functional genes/groups remained elevated over 9 months. Montel tests suggested that the dynamics in the abundance, composition, and structure of these key functional genes/groups were significantly correlated with groundwater concentrations of acetate, NO 3 -, Mn(II), Fe(II), U(VI), and SO 4 2-. Our results suggest that EVO amendment stimulated dynamic succession of key functional microbial communities. Finally, this study improves our understanding of the composition, structure, and function changes needed for groundwater microbial communities to sustain a long-term U(VI) reduction.« less

sedFlow - an efficient tool for simulating bedload transport, bed roughness, and longitudinal profile evolution in mountain streams

NASA Astrophysics Data System (ADS)

Heimann, F. U. M.; Rickenmann, D.; Turowski, J. M.; Kirchner, J. W.

2014-07-01

Especially in mountainuous environments, the prediction of sediment dynamics is important for managing natural hazards, assessing in-stream habitats, and understanding geomorphic evolution. We present the new modelling tool sedFlow for simulating fractional bedload transport dynamics in mountain streams. The model can deal with the effects of adverse slopes and uses state of the art approaches for quantifying macro-roughness effects in steep channels. Local grain size distributions are dynamically adjusted according to the transport dynamics of each grain size fraction. The tool sedFlow features fast calculations and straightforward pre- and postprocessing of simulation data. The model is provided together with its complete source code free of charge under the terms of the GNU General Public License (www.wsl.ch/sedFlow). Examples of the application of sedFlow are given in a companion article by Heimann et al. (2014).

Flow Mode Dependent Partitioning Processes of Preferential Flow Dynamics in Unsaturated Fractures - Findings From Analogue Percolation Experiments

NASA Astrophysics Data System (ADS)

Kordilla, J.; Noffz, T.; Dentz, M.; Sauter, M.

2017-12-01

To assess the vulnerability of an aquifer system it is of utmost importance to recognize the high potential for a rapid mass transport offered by ow through unsaturated fracture networks. Numerical models have to reproduce complex effects of gravity-driven flow dynamics to generate accurate predictions of flow and transport. However, the non-linear characteristics of free surface flow dynamics and partitioning behaviour at unsaturated fracture intersections often exceed the capacity of classical volume-effective modelling approaches. Laboratory experiments that manage to isolate single aspects of the mass partitioning process can enhance the understanding of underlying dynamics, which ultimately influence travel time distributions on multiple scales. Our analogue fracture network consists of synthetic cubes with dimensions of 20 x 20 x 20 cm creating simple geometries of a single or a cascade of consecutive horizontal fractures. Gravity-driven free surface flow (droplets; rivulets) is established via a high precision multichannel dispenser at flow rates ranging from 1.5 to 4.5 ml/min. Single-inlet experiments show the influence of variable flow rate, atmospheric pressure and temperature on the stability of flow modes and allow to delineate a droplet and rivulet regime. The transition between these regimes exhibits mixed flow characteristics. In addition, multi-inlet setups with constant total infow rates decrease the variance induced by erratic free-surface flow dynamics. We investigate the impacts of variable aperture widths, horizontal offsets of vertical fracture surfaces, and alternating injection methods for both flow regimes. Normalized fracture inflow rates allow to demonstrate and compare the effects of variable geometric features. Firstly, the fracture filling can be described by plug flow. At later stages it transitions into a Washburn-type flow, which we compare to an analytical solution for the case of rivulet flow. Observations show a considerably higher bypass effciency of droplet flow. This behaviour may not be recovered by plug flow but also transitions into a Washburn stage. Furthermore, we study the effect of additional cubes, i.e. increasing amount of horizontal fractures, on the bulk arrival times and associated importance of flow mode dependent partitioning processes.

Emplacement of Basaltic Lava Flows: the Legacy of GPL Walker

NASA Astrophysics Data System (ADS)

Cashman, K. V.

2005-12-01

Through his early field measurements of lava flow morphology, G.P.L. Walker established a framework for examination of the dynamics of lava flow emplacement that is still in place today. I will examine this legacy as established by three early papers: (1) his 1967 paper, where he defined a relationship between the thickness of recent Etna lava flows and the slope over which they flowed, a relationship that he ascribed to lava viscosity; (2) his 1971 paper, which defined a relationship between lava flux and the formation of simple and compound flow units that he used to infer high effusion rates for the emplacement of some flood basalt lavas; and (3) his often-cited 1973 paper, which related the length of lava flows to their average effusion rate. These three papers, all similar in their basic approach of using field measurements of lava flow morphology to extract fundamental relationships between eruption conditions (magma flux and rheology) and emplacement style (flow length and thickness), firmly established the relationship between flow morphology and emplacement dynamics that has since been widely applied not only to subaerial lava flows, but also to the interpretation of flows in submarine and planetary environments. Important extensions of these concepts have been provided by improved field observation methods, particularly for analysis of flowing lava, by laboratory measurements of lava rheology, by the application of analog experiments to lava flow dynamics, and by steady improvement of numerical techniques to model the flow of lava over complex terrain. The real legacy of G.P.L. Walker's field measurement approach, however, may lie in the future, as new topographic measurement techniques such as LIDAR hold exciting promise for truly quantitative analysis of lava flow morphologies and their relationship to flow dynamics.

Continuously measured renal blood flow does not increase in diabetes if nitric oxide synthesis is blocked.

PubMed

Bell, Tracy D; DiBona, Gerald F; Biemiller, Rachel; Brands, Michael W

2008-11-01

This study used 16 h/day measurement of renal blood flow (RBF) and arterial pressure (AP) to determine the role of nitric oxide (NO) in mediating the renal vasodilation caused by onset of type 1 diabetes. The AP and RBF power spectra were used to determine the autoregulatory efficiency of the renal vasculature. Rats were instrumented with artery and vein catheters and a Transonic flow probe on the left renal artery and were divided randomly into four groups: control (C), diabetes (D), control plus nitro-L-arginine methyl ester (L-NAME; CL), and diabetes plus L-NAME (DL). Mean AP averaged 90 +/- 1 and 121 +/- 1 mmHg in the D and DL groups, respectively, during the control period, and RBF averaged 5.9 +/- 1.2 and 5.7 +/- 0.7 ml/min, respectively. Respective C and CL groups were not different. Onset of diabetes (streptozotocin 40 mg/kg iv) in D rats increased RBF gradually, but it averaged 55% above control by day 14. In DL rats, on the other hand, RBF remained essentially constant, tracking with RBF in the nondiabetic C and CL groups for the 2-wk period. Diabetes did not change mean AP in any group. Transfer function analysis revealed impaired dynamic autoregulation of RBF overall, including the frequency range of tubuloglomerular feedback (TGF), and L-NAME completely prevented those changes as well. These data strongly support a role for NO in causing renal vasodilation in diabetes and suggest that an effect of NO to blunt RBF autoregulation may play an important role.

Continuously measured renal blood flow does not increase in diabetes if nitric oxide synthesis is blocked

PubMed Central

Bell, Tracy D.; DiBona, Gerald F.; Biemiller, Rachel; Brands, Michael W.

2008-01-01

This study used 16 h/day measurement of renal blood flow (RBF) and arterial pressure (AP) to determine the role of nitric oxide (NO) in mediating the renal vasodilation caused by onset of type 1 diabetes. The AP and RBF power spectra were used to determine the autoregulatory efficiency of the renal vasculature. Rats were instrumented with artery and vein catheters and a Transonic flow probe on the left renal artery and were divided randomly into four groups: control (C), diabetes (D), control plus nitro-l-arginine methyl ester (l-NAME; CL), and diabetes plus l-NAME (DL). Mean AP averaged 90 ± 1 and 121 ± 1 mmHg in the D and DL groups, respectively, during the control period, and RBF averaged 5.9 ± 1.2 and 5.7 ± 0.7 ml/min, respectively. Respective C and CL groups were not different. Onset of diabetes (streptozotocin 40 mg/kg iv) in D rats increased RBF gradually, but it averaged 55% above control by day 14. In DL rats, on the other hand, RBF remained essentially constant, tracking with RBF in the nondiabetic C and CL groups for the 2-wk period. Diabetes did not change mean AP in any group. Transfer function analysis revealed impaired dynamic autoregulation of RBF overall, including the frequency range of tubuloglomerular feedback (TGF), and l-NAME completely prevented those changes as well. These data strongly support a role for NO in causing renal vasodilation in diabetes and suggest that an effect of NO to blunt RBF autoregulation may play an important role. PMID:18753304

Ultrafast dynamic computed tomography myelography for the precise identification of high-flow cerebrospinal fluid leaks caused by spiculated spinal osteophytes.

PubMed

Thielen, Kent R; Sillery, John C; Morris, Jonathan M; Hoxworth, Joseph M; Diehn, Felix E; Wald, John T; Rosebrock, Richard E; Yu, Lifeng; Luetmer, Patrick H

2015-03-01

Precise localization and understanding of the origin of spontaneous high-flow spinal CSF leaks is required prior to targeted treatment. This study demonstrates the utility of ultrafast dynamic CT myelography for the precise localization of high-flow CSF leaks caused by spiculated spinal osteophytes. This study reports a series of 14 patients with high-flow CSF leaks caused by spiculated spinal osteophytes who underwent ultrafast dynamic CT myelography between March 2009 and December 2010. There were 10 male and 4 female patients, with an average age of 49 years (range 37-74 years). The value of ultrafast dynamic CT myelography in depicting the CSF leak site was qualitatively assessed. In all 14 patients, ultrafast dynamic CT myelography was technically successful at precisely demonstrating the site of the CSF leak, the causative spiculated osteophyte piercing the dura, and the relationship of the implicated osteophyte to adjacent structures. Leak sites included 3 cervical, 11 thoracic, and 0 lumbar levels, with 86% of the leaks occurring from C-5 to T-7. Information obtained from the ultrafast dynamic CT myelogram was considered useful in all treated CSF leaks. Spinal osteophytes piercing the dura are a more frequent cause of high-flow CSF leaks than previously recognized. Ultrafast dynamic CT myelography adds value beyond standard dynamic myelography or digital subtraction myelography in the diagnosis and anatomical characterization of high-flow spinal CSF leaks caused by these osteophytes. This information allows for appropriate planning for percutaneous or surgical treatment.

The role of His-83 of yeast apurinic/apyrimidinic endonuclease Apn1 in catalytic incision of abasic sites in DNA.

PubMed

Dyakonova, Elena S; Koval, Vladimir V; Lomzov, Alexander A; Ishchenko, Alexander A; Fedorova, Olga S

2015-06-01

The apurinic/apyrimidinic (AP) endonuclease Apn1 from Saccharomyces cerevisiae is a key enzyme involved in the base excision repair (BER) at the cleavage stage of abasic sites (AP sites) in DNA. The crystal structure of Apn1 from S. cerevisiae is unresolved. Based on its high amino acid homology to Escherichia coli Endo IV, His-83 is believed to coordinate one of three Zn2+ ions in Apn1's active site similar to His-69 in Endo IV. Substituting His-83 with Ala is proposed to decrease the AP endonuclease activity of Apn1 owing to weak coordination of Zn2+ ions involved in enzymatic catalysis. The kinetics of recognition, binding, and incision of DNA substrates with the H83A Apn1 mutant was investigated. The stopped-flow method detecting fluorescence intensity changes of 2-aminopurine (2-aPu) was used to monitor the conformational dynamics of DNA at pre-steady-state conditions. We found substituting His-83 with Ala influenced catalytic complex formation and further incision of the damaged DNA strand. The H83A Apn1 catalysis depends not only on the location of the mismatch relative to the abasic site in DNA, but also on the nature of damage. We consider His-83 properly coordinates the active site Zn2+ ion playing a crucial role in catalytic incision stage. Our data prove suppressed enzymatic activity of H83A Apn1 results from the reduced number of active site Zn2+ ions. Our study provides insights into mechanistic specialty of AP site repair by yeast AP endonuclease Apn1 of Endo IV family, which members are not found in mammals, but are present in many microorganisms. The results will provide useful guidelines for design of new anti-fungal and anti-malarial agents. Copyright © 2015 Elsevier B.V. All rights reserved.

Interactions of infectious F-specific RNA bacteriophages with suspended matter and sediment: Towards an understanding of FRNAPH distribution in a river water system.

PubMed

Fauvel, Blandine; Ogorzaly, Leslie; Cauchie, Henry-Michel; Gantzer, Christophe

2017-01-01

The association of viruses with settling particles is certainly a major process controlling the spread of viral pollution in surface water and sediment. To better understand the viral distribution in a river system, the behavior of F-specific RNA bacteriophages (FRNAPHs) was investigated in relationship with the suspended solids and sediment. The partitioning of phage particles (free or associated with solids) in surface water and the attachment capabilities of eight distinct strains of phages to sediment were studied in lab experiments. In situ observations were also performed with the genotyping of 166 individual plaques of FRNAPHs isolated from surface water and sediment. The results reported here demonstrate a variation of the status of infectious phages as a function of the hydro-climatological conditions. Phage-solid association seems to mainly occur during the peak of rainfall-runoff events but also to a certain extent during the recession phase compared to low flow conditions. The transfer of phages from the water column to sediment may occur at this time. Furthermore, the ability of FRNAPHs to interact with sediment was established for six strains out of eight, belonging to genogroups II, III and IV. A similar dynamic was observed for strains within a same genogroup despite different intensity of attachment and inactivation rates for strains of genogroups III and IV. The latter results match the in situ observations in the water and sediment compartments of the studied area. Infectious FRNAPH genogroup II was more abundant in sediment than in surface water. Its capability to sorb to sediment and its higher persistence in the environment compared to genogroups III and IV were the two main explanations. Together, lab and in situ experiments produce an overall vision of the mechanisms governing FRNAPH distribution among the water column and riverbed sediment. Copyright © 2016 Office national des forêts. Published by Elsevier B.V. All rights reserved.

Traffic jam dynamics in stochastic cellular automata

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nagel, K.; Schreckenberg, M.

1995-09-01

Simple models for particles hopping on a grid (cellular automata) are used to simulate (single lane) traffic flow. Despite their simplicity, these models are astonishingly realistic in reproducing start-stop-waves and realistic fundamental diagrams. One can use these models to investigate traffic phenomena near maximum flow. A so-called phase transition at average maximum flow is visible in the life-times of jams. The resulting dynamic picture is consistent with recent fluid-dynamical results by Kuehne/Kerner/Konhaeuser, and with Treiterer`s hysteresis description. This places CA models between car-following models and fluid-dynamical models for traffic flow. CA models are tested in projects in Los Alamos (USA)more » and in NRW (Germany) for large scale microsimulations of network traffic.« less

Dynamic MRI for distinguishing high-flow from low-flow peripheral vascular malformations.

PubMed

Ohgiya, Yoshimitsu; Hashimoto, Toshi; Gokan, Takehiko; Watanabe, Shouji; Kuroda, Masayoshi; Hirose, Masanori; Matsui, Seishi; Nobusawa, Hiroshi; Kitanosono, Takashi; Munechika, Hirotsugu

2005-11-01

The purpose of our study was to assess the usefulness of dynamic MRI in distinguishing high-flow vascular malformations from low-flow vascular malformations, which do not need angiography for treatment. Between September 2001 and January 2003, 16 patients who underwent conventional and dynamic MRI had peripheral vascular malformations (six high- and 10 low-flow). The temporal resolution of dynamic MRI was 5 sec. Time intervals between beginning of enhancement of an arterial branch in the vicinity of a lesion in the same slice and the onset of enhancement in the lesion were calculated. We defined these time intervals as "artery-lesion enhancement time." Time intervals between the onset of enhancement in the lesion and the time of the maximal percentage of enhancement above baseline of the lesion within 120 sec were measured. We defined these time intervals as "contrast rise time" of the lesion. Diagnosis of the peripheral vascular malformations was based on angiographic or venographic findings. The mean artery-lesion enhancement time of the high-flow vascular malformations (3.3 sec [range, 0-5 sec]) was significantly shorter than that of the low-flow vascular malformations (8.8 sec [range, 0-20 sec]) (Mann-Whitney test, p < 0.05). The mean maximal lesion enhancement time of the high-flow vascular malformations (5.8 sec [range, 5-10 sec]) was significantly shorter than that of the low-flow vascular malformations (88.4 sec [range, 50-100 sec]) (Mann-Whitney test, p < 0.01). Dynamic MRI is useful for distinguishing high-flow from low-flow vascular malformations, especially when the contrast rise time of the lesion is measured.

Low-angle dunes in the Changjiang (Yangtze) Estuary: Flow and sediment dynamics under tidal influence

NASA Astrophysics Data System (ADS)

Hu, Hao; Wei, Taoyuan; Yang, Zhongyong; Hackney, Christopher R.; Parsons, Daniel R.

2018-05-01

It has long been highlighted that important feedbacks exist between river bed morphology, sediment transport and the turbulent flow field and that these feedbacks change in response to forcing mechanisms. However, our current understanding of bedform dynamics is largely based on studies of steady flow environments and cohesionless bed conditions. Few investigations have been made under rapidly changing flows. Here, we examine flow and sediment dynamics over low-angle dunes in unsteady flows in the Changjiang (Yangtze) Estuary, China. Topography, flow and sediment data were collected over a reach ca 1.8 km long through a semi-diurnal tidal cycle in a moderate tide of flood season. The results show that: (1) roughness length derived from the upper flow changes little with the flow reversing and displays the same value on both the ebb and flood tide. Moreover, the variability of individual bedform features plays an important role in roughness length variation. (2) Shear stress over the crest of low-angle dunes roughly represents the total spatially averaged stress over dunes in this study area, which has significant implications for advancing numerical models. (3) Changes in morphology, flow and sediment dynamics over dunes through time reveal how low-angle dunes evolve within a tidal cycle. (4) The clockwise hysteresis loops between flow dynamics and bedform features (height and aspect ratio) are also observed. The combination of suspended sediment transport and bedload transport on dune transformation and migration attributes to the clockwise hysteresis. The specific sediment composition of the riverbed, in some extent, affects the mechanism of sediment transport related to the exchange between suspended sediment and riverbed, but further investigation is needed to figure out the mechanism behind this for extended series of tides, such as spring/neap tide and tides in flooding and dry season.

Flow volume loops in patients with goiters.

PubMed Central

Geraghty, J G; Coveney, E C; Kiernan, M; O'Higgins, N J

1992-01-01

Plain radiology is the standard means of assessing upper airway obstruction in patients with goiters. Flow volume loop curves will provide additional information, because they allow a quantitative assessment of airflow dynamics in the respiratory cycle. Fifty-one patients had flow volume loops performed before and after thyroidectomy. There was a significant increase in the maximum inspiratory flow rate (3.9 +/- 0.2 versus 4.9 +/- 0.2 L/second, p less than 0.01) after thyroidectomy. Eight of twelve patients with normal tracheal radiology had improved airflow dynamics in the postoperative period. The flow volume loop curve is a simple noninvasive means of assessing airflow dynamics in patients with goiters and may be superior to conventional radiology. PMID:1731653

Hyporheic hot moments: Dissolved oxygen dynamics in the hyporheic zone in response to surface flow perturbations

NASA Astrophysics Data System (ADS)

Kaufman, Matthew H.; Cardenas, M. Bayani; Buttles, Jim; Kessler, Adam J.; Cook, Perran L. M.

2017-08-01

Dissolved oxygen (DO) is a key environmental variable that drives and feeds back with numerous processes. In the aquatic sediment that makes up the hyporheic zone, DO may exhibit pronounced spatial gradients and complex patterns which control the distribution of a series of redox processes. Yet, little is known regarding the dynamics of hyporheic zone DO, especially under transitional flow regimes. Considering the natural tendency of rivers to be highly responsive to external forcing, these temporal dynamics are potentially just as important and pronounced as the spatial gradients. Here we use laboratory flume experiments and multiphysics flow and reactive transport modeling to investigate surface flow controls on the depth of oxygen penetration in the bed as well as the area of oxygenated sediment. We show that the hyporheic zone DO conditions respond over time scales of hours-to-days when subjected to practically instantaneous surface flow perturbations. Additionally, the flume experiments demonstrate that hyporheic zone DO conditions respond faster to surface flow acceleration than to deceleration. Finally, we found that the morphology of the dissolved oxygen plume front depends on surface flow acceleration or deceleration. This study thus shows that the highly dynamic nature of typical streams and rivers drives equally dynamic redox conditions in the hyporheic zone. Because the redox conditions and their distribution within the hyporheic zone are important from biological, ecological, and contaminant perspectives, this hyporheic redox dynamism has the potential to impact system scale aquatic chemical cycles.

Modeling of I-V characteristics in a 3-channel SFFT with nanobridges by gate current signals

NASA Astrophysics Data System (ADS)

Yu, Byunggyu; Kim, Young-Pil; Ko, Seok-Cheol

2018-04-01

A superconducting flux flow transistor (SFFT) with three channels and nanobridges was successfully fabricated by electron beam (e-beam) lithography and an Ar ion milling technique. The SFFT is composed of three weak links with a nearby gate current line. We explain the process to obtain the equation for the current-voltage characteristics and describe the method to induce external and internal magnetic fields by Biot-Savart's law. The equation can be used to predict the current-voltage curves for the 3-channel SFFT fabricated using e-beam lithography. I-V characteristics were simulated to analyze the SFFT with three channels and nanobridges by a Matlab program. From the I-V characteristics equation of the 3-channel SFFT, the drain currents and the output voltages as the gate current is applied are graphically compared with the measured value and the simulation value. The simulated I-V curves were in good agreement with the measured curves of the 3-channel SFFT with nanobridges.

Increased levels of circulating platelet-derived microparticles are associated with metastatic cutaneous melanoma.

PubMed

Moreau, Joséphine; Pelletier, Fabien; Biichle, Sabeha; Mourey, Guillaume; Puyraveau, Marc; Badet, Nicolas; Caubet, Matthieu; Laresche, Claire; Garnache-Ottou, Francine; Saas, Philippe; Seilles, Estelle; Aubin, François

2017-10-01

We investigated the plasma levels of PMPs in patients with 45 stage III and 45 stage IV melanoma. PMPs were characterised by flow cytometry and their thrombogenic activity. We also investigated the link between PMPs circulating levels and tumor burden. The circulating levels of PMPs were significantly higher in stage IV (8500 μL -1 ) than in patients with stage III (2041 μL -1 ) melanoma (P=.0001). We calculated a highly specific (93.3%) and predictive (91.7%) cut-off value (5311 μL -1 ) allowing the distinction between high-risk stage III and metastatic stage IV melanoma. The thrombogenic activity of PMPs was significantly higher in patients with stage IV melanoma (clotting time: 40.7 second vs 65 second, P=.0001). There was no significant association between the radiological tumoral syndrome and the plasma level of PMPs. Our data suggest the role of PMPs in metastatic progression of melanoma. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Energy use in the marine transportation industry: Task III. Efficiency improvements; Task IV. Industry future. Final report, Volume IV. [Projections for year 2000

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1977-12-01

Tasks III and IV measure the characteristics of potential research and development programs that could be applied to the maritime industry. It was necessary to identify potential operating scenarios for the maritime industry in the year 2000 and determine the energy consumption that would result given those scenarios. After the introductory chapter the operational, regulatory, and vessel-size scenarios for the year 2000 are developed in Chapter II. In Chapter III, future cargo flows and expected levels of energy use for the baseline 2000 projection are determined. In Chapter IV, the research and development programs are introduced into the future USmore » flag fleet and the energy-savings potential associated with each is determined. The first four appendices (A through D) describe each of the generic technologies. The fifth appendix (E) contains the baseline operating and cost parameters against which 15 program areas were evaluated. (MCW)« less

Solid-phase extraction of iridium from soil and water samples by using activated carbon cloth prior to its spectrophotometric determination.

PubMed

Ozkantar, Nebiye; Yilmaz, Erkan; Soylak, Mustafa; Tuzen, Mustafa

2015-08-01

A solid-phase extraction method for separation and preconcentration of Ir(IV) ion by using activated carbon cloth (ACC) has been presented. Ir(IV) as their 1-(2-pyridylazo) 2-naphtol (PAN) chelate was adsorbed on ACC at pH 2.0 and was eluted from ACC with acidic dimethylformamide (DMF). The Ir(IV) concentration was determined at 536 nm as Ir(IV)-PAN complex by using UV-vis spectrophotometer. The analytical parameters including pH, sample and eluent flow rates, amount of PAN, eluent type, concentration, and sample volume were optimized. The effects of foreign ions on the recoveries of iridium were also investigated. The preconcentration factor was calculated as 60. The limit of detection (LOD) and the limit of quantification (LOQ) of the method were found as 0.039 and 0.129 μg L(-1), respectively. The method was applied to soil and water samples for iridium determination.

Self organized spatio-temporal structure within the fractured Vadose Zone: The influence of dynamic overloading at fracture intersections

NASA Astrophysics Data System (ADS)

LaViolette, Randall A.; Glass, Robert J.

2004-09-01

Under low flow conditions (where gravity and capillary forces dominate) within an unsaturated fracture network, fracture intersections act as capillary barriers to integrate flow from above and then release it as a pulse below. Water exiting a fracture intersection is often thought to enter the single connected fracture with the lowest invasion pressure. When the accumulated volume varies between intersections, the smaller volume intersections can be overloaded to cause all of the available fractures exiting an intersection to flow. We included the dynamic overloading process at fracture intersections within our previously discussed model where intersections were modeled as tipping buckets connected within a two-dimensional diamond lattice. With dynamic overloading, the flow behavior transitioned smoothly from diverging to converging flow with increasing overload parameter, as a consequence of a heterogeneous field, and they impose a dynamic structure where additional pathways activate or deactivate in time.

ISCFD Nagoya 1989 - International Symposium on Computational Fluid Dynamics, 3rd, Nagoya, Japan, Aug. 28-31, 1989, Technical Papers

NASA Astrophysics Data System (ADS)

Recent advances in computational fluid dynamics are discussed in reviews and reports. Topics addressed include large-scale LESs for turbulent pipe and channel flows, numerical solutions of the Euler and Navier-Stokes equations on parallel computers, multigrid methods for steady high-Reynolds-number flow past sudden expansions, finite-volume methods on unstructured grids, supersonic wake flow on a blunt body, a grid-characteristic method for multidimensional gas dynamics, and CIC numerical simulation of a wave boundary layer. Consideration is given to vortex simulations of confined two-dimensional jets, supersonic viscous shear layers, spectral methods for compressible flows, shock-wave refraction at air/water interfaces, oscillatory flow in a two-dimensional collapsible channel, the growth of randomness in a spatially developing wake, and an efficient simplex algorithm for the finite-difference and dynamic linear-programming method in optimal potential control.

A reduced-order model for compressible flows with buffeting condition using higher order dynamic mode decomposition with a mode selection criterion

NASA Astrophysics Data System (ADS)

Kou, Jiaqing; Le Clainche, Soledad; Zhang, Weiwei

2018-01-01

This study proposes an improvement in the performance of reduced-order models (ROMs) based on dynamic mode decomposition to model the flow dynamics of the attractor from a transient solution. By combining higher order dynamic mode decomposition (HODMD) with an efficient mode selection criterion, the HODMD with criterion (HODMDc) ROM is able to identify dominant flow patterns with high accuracy. This helps us to develop a more parsimonious ROM structure, allowing better predictions of the attractor dynamics. The method is tested in the solution of a NACA0012 airfoil buffeting in a transonic flow, and its good performance in both the reconstruction of the original solution and the prediction of the permanent dynamics is shown. In addition, the robustness of the method has been successfully tested using different types of parameters, indicating that the proposed ROM approach is a tool promising for using in both numerical simulations and experimental data.

OSO-8 observations of the impulsive phase of solar flares in the transition-zone and corona

NASA Technical Reports Server (NTRS)

Lites, B. W.; Bruner, E. C., Jr.; Wolfson, C. J.

1981-01-01

Several solar flares were observed from their onset in C IV 1548.2 A and 1-8 A X-rays using instruments on OSO-8. It is found that impulsive brightening in C IV is often accompanied by redshifts, interpreted as downflows, of the order of 80 km/s. The maximum soft X-ray intensity usually arrives several minutes after the maximum C IV intensity. The most energetic C IV event observed shows a small blueshift just before reaching maximum intensity; estimates of the mass flux associated with this upflow through the transition zone are consistent with the increase of mass in the coronal loops as observed in soft X-rays. Finally, it is suggested that the frequent occurrence of violent dynamical processes at the onset of the flare is associated with the initial energy release mechanism.

Determination of the analgesic components of Spasmomigraine tablet by liquid chromatography with ultraviolet detection.

PubMed

Elbarbry, Fawzy A; Mabrouk, Mokhtar M; El-Dawy, Mohamed A

2007-01-01

A procedure was developed for the determination of the analgesic components of Spasmomigraine tablets, which are ergotamine (I), propyphenazone (II), caffeine (III), camylofin (IV), and mecloxamine (V). They were subjected to high-performance liquid chromatography on a column (300 x 3.9 mm, 10 rlm particle size) packed with micro-Bondapak C18. Separations were achieved with the mobile phase methanol-water-triethylamine (60 + 40 + 0.1, v/v/v) flowing at a rate of 1.5 mL/min, and quantitative determination was performed at 254 nm at ambient temperature for I-III; acetonitrile-25 mM KH2PO4-acetic acid (45 + 55 + 0.2, v/v/v), flowing at a rate of 1.5 mL/min and detection at 234 nm at ambient temperature, was used for IV and V. Methyl paraben was used as an internal standard. The detection limits were 0.35 (I), 5.0 (11), 1.5 (111), 3.0 (IV), and 2.0 microg/mL (V). The method was accurate (mean recovery 98+/-2%, n = 4) and precise (coefficient of variation <5%, n = 5). The proposed method is rapid and sensitive and, therefore, suitable for the routine control of these ingredients in multicomponent dosage forms.

Cocrystal habit engineering to improve drug dissolution and alter derived powder properties.

PubMed

Serrano, Dolores R; O'Connell, Peter; Paluch, Krzysztof J; Walsh, David; Healy, Anne Marie

2016-05-01

Cocrystallization of sulfadimidine (SDM) with suitable coformers, such as 4-aminosalicylic acid (4-ASA), combined with changes in the crystal habit can favourably alter its physicochemical properties. The aim of this work was to engineer SDM : 4-ASA cocrystals with different habits to investigate the effect on dissolution, and the derived powder properties of flow and compaction. Cocrystals were prepared in a 1 : 1 molar ratio by solvent evaporation using ethanol (habit I) or acetone (habit II), solvent evaporation followed by grinding (habit III) and spray drying (habit IV). Powder X-ray diffraction showed Bragg peak position was the same in all the solid products. The peak intensity varied, indicating different preferred crystal orientation confirmed by SEM micrographs: large prismatic crystals (habit I), large plate-like crystals (habit II), small cube-like crystals (habit III) and microspheres (habit IV). The habit III exhibited the fasted dissolution rate; however, it underwent a polymorphic transition during dissolution. Habits I and IV exhibited the highest Carr's compressibility index, indicating poor flowability. However, habits II and III demonstrated improved flow. Spray drying resulted in cocrystals with improved compaction properties. Even for cocrystals with poor pharmaceutical characteristics, a habit can be engineered to alter the dissolution, flowability and compaction behaviour. © 2015 Royal Pharmaceutical Society.

A Lagrangian dynamic subgrid-scale model turbulence

NASA Technical Reports Server (NTRS)

Meneveau, C.; Lund, T. S.; Cabot, W.

1994-01-01

A new formulation of the dynamic subgrid-scale model is tested in which the error associated with the Germano identity is minimized over flow pathlines rather than over directions of statistical homogeneity. This procedure allows the application of the dynamic model with averaging to flows in complex geometries that do not possess homogeneous directions. The characteristic Lagrangian time scale over which the averaging is performed is chosen such that the model is purely dissipative, guaranteeing numerical stability when coupled with the Smagorinsky model. The formulation is tested successfully in forced and decaying isotropic turbulence and in fully developed and transitional channel flow. In homogeneous flows, the results are similar to those of the volume-averaged dynamic model, while in channel flow, the predictions are superior to those of the plane-averaged dynamic model. The relationship between the averaged terms in the model and vortical structures (worms) that appear in the LES is investigated. Computational overhead is kept small (about 10 percent above the CPU requirements of the volume or plane-averaged dynamic model) by using an approximate scheme to advance the Lagrangian tracking through first-order Euler time integration and linear interpolation in space.

Regional cerebral blood flow measurement with intravenous ( sup 15 O)water bolus and ( sup 18 F)fluoromethane inhalation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Herholz, K.; Pietrzyk, U.; Wienhard, K.

1989-09-01

In 20 patients with ischemic cerebrovascular disease, classic migraine, or angiomas, we compared paired dynamic positron emission tomographic measurements of regional cerebral blood flow using both ({sup 15}O)water and ({sup 18}F)fluoromethane as tracers. Cerebral blood flow was also determined according to the autoradiographic technique with a bolus injection of ({sup 15}O)water. There were reasonable overall correlations between dynamic ({sup 15}O)water and ({sup 18}F)fluoromethane values for cerebral blood flow (r = 0.82) and between dynamic and autoradiographic ({sup 15}O)water values for cerebral blood flow (r = 0.83). We found a close correspondence between abnormal pathologic findings and visually evaluated cerebral bloodmore » flow tomograms obtained with the two tracers. On average, dynamic ({sup 15}O)water cerebral blood flow was 6% lower than that measured with ({sup 18}F)fluoromethane. There also was a general trend toward a greater underestimation with ({sup 15}O)water in high-flow areas, particularly in hyperemic areas, probably due to incomplete first-pass extraction of ({sup 15}O)water. Underestimation was not detected in low-flow areas or in the cerebellum. Absolute cerebral blood flow values were less closely correlated between tracers and techniques than cerebral blood flow patterns. The variability of the relation between absolute flow values was probably caused by confounding effects of the variation in the circulatory delay time. The autoradiographic technique was most sensitive to this type error.« less

Robust control of combustion instabilities

NASA Astrophysics Data System (ADS)

Hong, Boe-Shong

Several interactive dynamical subsystems, each of which has its own time-scale and physical significance, are decomposed to build a feedback-controlled combustion- fluid robust dynamics. On the fast-time scale, the phenomenon of combustion instability is corresponding to the internal feedback of two subsystems: acoustic dynamics and flame dynamics, which are parametrically dependent on the slow-time-scale mean-flow dynamics controlled for global performance by a mean-flow controller. This dissertation constructs such a control system, through modeling, analysis and synthesis, to deal with model uncertainties, environmental noises and time- varying mean-flow operation. Conservation law is decomposed as fast-time acoustic dynamics and slow-time mean-flow dynamics, served for synthesizing LPV (linear parameter varying)- L2-gain robust control law, in which a robust observer is embedded for estimating and controlling the internal status, while achieving trade- offs among robustness, performances and operation. The robust controller is formulated as two LPV-type Linear Matrix Inequalities (LMIs), whose numerical solver is developed by finite-element method. Some important issues related to physical understanding and engineering application are discussed in simulated results of the control system.

Microfluidic flow rate detection based on integrated optical fiber cantilever.

PubMed

Lien, Victor; Vollmer, Frank

2007-10-01

We demonstrate an integrated microfluidic flow sensor with ultra-wide dynamic range, suitable for high throughput applications such as flow cytometry and particle sorting/counting. A fiber-tip cantilever transduces flow rates to optical signal readout, and we demonstrate a dynamic range from 0 to 1500 microL min(-1) for operation in water. Fiber-optic sensor alignment is guided by preformed microfluidic channels, and the dynamic range can be adjusted in a one-step chemical etch. An overall non-linear response is attributed to the far-field angular distribution of single-mode fiber output.

An ultrasonic flowmeter for measuring dynamic liquid flow

NASA Technical Reports Server (NTRS)

Carpini, T. D.; Monteith, J. H.

1978-01-01

A novel oscillating pipe system was developed to provide dynamic calibration wherein small sinusoidal signals with amplitudes of 0.5 to 10% of the steady-state flow were added to the steady-state flow by oscillating the flowmeter relative to the fixed pipes in the flow system. Excellent agreement was obtained between the dynamic velocities derived from an accelerometer mounted on the oscillating pipe system and those sensed by the flowmeter at frequencies of 7, 19, and 30 Hz. Also described were the signal processing techniques used to retrieve the small sinusoidal signals which were obscured by the fluid turbulence.

The impact of simplified boundary conditions and aortic arch inclusion on CFD simulations in the mouse aorta: a comparison with mouse-specific reference data.

PubMed

Trachet, Bram; Bols, Joris; De Santis, Gianluca; Vandenberghe, Stefaan; Loeys, Bart; Segers, Patrick

2011-12-01

Computational fluid dynamics (CFD) simulations allow for calculation of a detailed flow field in the mouse aorta and can thus be used to investigate a potential link between local hemodynamics and disease development. To perform these simulations in a murine setting, one often needs to make assumptions (e.g. when mouse-specific boundary conditions are not available), but many of these assumptions have not been validated due to a lack of reference data. In this study, we present such a reference data set by combining high-frequency ultrasound and contrast-enhanced micro-CT to measure (in vivo) the time-dependent volumetric flow waveforms in the complete aorta (including seven major side branches) of 10 male ApoE -/- deficient mice on a C57Bl/6 background. In order to assess the influence of some assumptions that are commonly applied in literature, four different CFD simulations were set up for each animal: (i) imposing the measured volumetric flow waveforms, (ii) imposing the average flow fractions over all 10 animals, presented as a reference data set, (iii) imposing flow fractions calculated by Murray's law, and (iv) restricting the geometrical model to the abdominal aorta (imposing measured flows). We found that - even if there is sometimes significant variation in the flow fractions going to a particular branch - the influence of using average flow fractions on the CFD simulations is limited and often restricted to the side branches. On the other hand, Murray's law underestimates the fraction going to the brachiocephalic trunk and strongly overestimates the fraction going to the distal aorta, influencing the outcome of the CFD results significantly. Changing the exponential factor in Murray's law equation from 3 to 2 (as suggested by several authors in literature) yields results that correspond much better to those obtained imposing the average flow fractions. Restricting the geometrical model to the abdominal aorta did not influence the outcome of the CFD simulations. In conclusion, the presented reference dataset can be used to impose boundary conditions in the mouse aorta in future studies, keeping in mind that they represent a subsample of the total population, i.e., relatively old, non-diseased, male C57Bl/6 ApoE -/- mice.

Dynamic change in mitral regurgitant orifice area: comparison of color Doppler echocardiographic and electromagnetic flowmeter-based methods in a chronic animal model.

PubMed

Shiota, T; Jones, M; Teien, D E; Yamada, I; Passafini, A; Ge, S; Sahn, D J

1995-08-01

The aim of the present study was to investigate dynamic changes in the mitral regurgitant orifice using electromagnetic flow probes and flowmeters and the color Doppler flow convergence method. Methods for determining mitral regurgitant orifice areas have been described using flow convergence imaging with a hemispheric isovelocity surface assumption. However, the shape of flow convergence isovelocity surfaces depends on many factors that change during regurgitation. In seven sheep with surgically created mitral regurgitation, 18 hemodynamic states were studied. The aliasing distances of flow convergence were measured at 10 sequential points using two ranges of aliasing velocities (0.20 to 0.32 and 0.56 to 0.72 m/s), and instantaneous flow rates were calculated using the hemispheric assumption. Instantaneous regurgitant areas were determined from the regurgitant flow rates obtained from both electromagnetic flowmeters and flow convergence divided by the corresponding continuous wave velocities. The regurgitant orifice sizes obtained using the electromagnetic flow method usually increased to maximal size in early to midsystole and then decreased in late systole. Patterns of dynamic changes in orifice area obtained by flow convergence were not the same as those delineated by the electromagnetic flow method. Time-averaged regurgitant orifice areas obtained by flow convergence using lower aliasing velocities overestimated the areas obtained by the electromagnetic flow method ([mean +/- SD] 0.27 +/- 0.14 vs. 0.12 +/- 0.06 cm2, p < 0.001), whereas flow convergence, using higher aliasing velocities, estimated the reference areas more reliably (0.15 +/- 0.06 cm2). The electromagnetic flow method studies uniformly demonstrated dynamic change in mitral regurgitant orifice area and suggested limitations of the flow convergence method.

Nodal Cilia Dynamics and the Specification of the Left/Right Axis in Early Vertebrate Embryo Development

PubMed Central

Buceta, Javier; Ibañes, Marta; Rasskin-Gutman, Diego; Okada, Yasushi; Hirokawa, Nobutaka; Izpisúa-Belmonte, Juan Carlos

2005-01-01

Nodal cilia dynamics is a key factor for left/right axis determination in mouse embryos through the induction of a leftward fluid flow. So far it has not been clearly established how such dynamics is able to induce the asymmetric leftward flow within the node. Herein we propose that an asymmetric two-phase nonplanar beating cilia dynamics that involves the bending of the ciliar axoneme is responsible for the leftward fluid flow. We support our proposal with a host of hydrodynamic arguments, in silico experiments and in vivo video microscopy data in wild-type embryos and inv mutants. Our phenomenological modeling approach underscores how the asymmetry and speed of the flow depends on different relevant parameters. In addition, we discuss how the combination of internal and external mechanisms might cause the two-phase beating cilia dynamics. PMID:16040754

49 CFR 173.121 - Class 3-Assignment of packing group.

Code of Federal Regulations, 2013 CFR

2013-10-01

... than 100 L (26.3 gallons); and (iv) The viscosity and flash point are in accordance with the following... paragraph (b)(1) of this section shall be performed are as follows: (i) Viscosity test. The flow time in...

49 CFR 173.121 - Class 3-Assignment of packing group.

Code of Federal Regulations, 2014 CFR

2014-10-01

... than 100 L (26.3 gallons); and (iv) The viscosity and flash point are in accordance with the following... paragraph (b)(1) of this section shall be performed are as follows: (i) Viscosity test. The flow time in...

INDEPENDENT VERIFICATION SURVEY REPORT FOR ZONE 1 OF THE EAST TENNESSEE TECHNOLOGY PARK IN OAK RIDGE, TENNESSEE

DOE Office of Scientific and Technical Information (OSTI.GOV)

King, David A.

2012-08-16

Oak Ridge Associated Universities (ORAU) conducted in-process inspections and independent verification (IV) surveys in support of DOE's remedial efforts in Zone 1 of East Tennessee Technology Park (ETTP) in Oak Ridge, Tennessee. Inspections concluded that the remediation contractor's soil removal and survey objectives were satisfied and the dynamic verification strategy (DVS) was implemented as designed. Independent verification (IV) activities included gamma walkover surveys and soil sample collection/analysis over multiple exposure units (EUs).

Studies on the prevalence of reduced salivary flow rate in relation to general health and dental caries, and effect of iron supplementation.

PubMed

Flink, Håkan

2007-01-01

Reduced salivary flow is a condition that affects oral health. Its prevalence is unknown in young and middle-aged adults and there is no known treatment that permanently increases the salivary flow rate. Reduced salivary flow is related to dental caries, the most common oral disease. Reduced salivary flow is often found in individuals with insufficient food intake and thereby insufficient nutrition to the salivary glands. One nutrition related factor that has been proposed to effect salivary flow rate is iron deficiency. The aims of the thesis were to investigate i) the prevalence of reduced salivary flow rate in different age groups of adults, ii) the relationship between reduced salivary flow rate, general health and dental caries, iii) the influence of time of measurement on reduced salivary flow rate, and iv) if reduced salivary flow rates could be increased by iron supplementation. In Study I saliva was collected from 1427 individuals aged 20-69 years. A questionnaire was answered regarding subjective oral dryness, general diseases, use of drugs, BMI (Body Mass Index) and use of tobacco. In Study II saliva was collected from 48 patients with active caries and 48 caries-inactive patients. A blood sample was analysed for serum ferritin. In Study III the unstimulated salivary flow rate was tested at 7:30 and 11:30 a.m. in 108 individuals, age 15-46 years. The participants were allocated to one of three groups (very low < 0.1 mL/min, low 0.1-0.2 mL/min and normal > 0.2 mL/min) based on the the unstimulated salivary flow rate at 7:30 a.m. Different aspects of the perception of oral dryness were rated using Visual Analogue Scales. In Study IV a double-blind, randomized controlled trial was carried out on 50 individuals with a low unstimulated whole salivary flow rate and low serum ferritin. Half the individuals received 60 mg of iron orally twice a day for 3 months, while the other half received placebo. In Study I it was found that the prevalence of very low (< 0.1 mL/min) and low (0.10-0.19 mL/min) unstimulated salivary flow rate were similar for different age groups up to 50 years, ranging between 10.9-17.8% and 17.3-22.7%, respectively. Multiple logistic regression revealed that above age 50, female gender, 'having fewer than 20 teeth', and taking xerogenic drugs significantly increased the risk of very low unstimulated salivary flow rate. In Study II 32 individuals (67%) in the caries active group had low unstimulated salivary flow rate compared with 13 individuals (27%) in the caries inactive group. There was no difference in serum ferritin levels between the two groups. Study III showed for all groups a statistically significant increase in unstimulated salivary flow rate at 11:30 a.m. compared with 7:30 a.m., all of similar magnitude (0.08-0.09 mL/min). In the group with very low salivary flow rate, 70% at 11:30 a.m. exceeded the 0.1 mL/min limit. There were significant difference in perception of oral dryness between the normal group and both the low and the very low groups. In Study IV no statistically significant difference was found between the groups after treatment for the unstimulated flow rate and in the subjective assessments of oral dryness. The prevalence of reduced salivary flow rates is consistent and prevalent in younger and middle-aged adults (< 50 years). Very low salivary flow rates are related to high Body Mass Index (BMI) and diagnosed diseases in younger adults, but to medication in older adults. Reduced salivary flow rate in young adult women is related to caries. The time of measurement of salivary flow rates influences diagnosis of hyposalivation. Iron supplementation does not enhance salivary flow.

Flow Visualization of Dynamic Stall on an Oscillating Airfoil

DTIC Science & Technology

1989-09-01

Dynamic Stall; Dynamic lift, ’Unsteady lift; Helicopter retreating blade stall; Oscillating airfoil ; Flow visualization,’Schlieren method ;k ez.S-,’ .0...the degree of MASTER OF SCIENCE IN AERONAUTICAL ENGINEERING from the NAVAL POSTGRADUATE SCHOOL September 1989 Author...and moment behavior is quite different from the static stall associated with fixed-wing airfoils . Helicopter retreating blade stall is a dynamic

A Study of Bubble and Slug Gas-Liquid Flow in a Microgravity Environment

NASA Technical Reports Server (NTRS)

McQuillen, J.

2000-01-01

The influence of gravity on the two-phase flow dynamics is obvious.As the gravity level is reduced,there is a new balance between inertial and interfacial forces, altering the behavior of the flow. In bubbly flow,the absence of drift velocity leads to spherical-shaped bubbles with a rectilinear trajectory.Slug flow is a succession of long bubbles and liquid slug carrying a few bubbles. There is no flow reversal in the thin liquid film as the long bubble and liquid slug pass over the film. Although the flow structure seems to be simpler than in normal gravity conditions,the models developed for the prediction of flow behavior in normal gravity and extended to reduced gravity flow are unable to predict the flow behavior correctly.An additional benefit of conducting studies in microgravity flows is that these studies aide the development of understanding for normal gravity flow behavior by removing the effects of buoyancy on the shape of the interface and density driven shear flows between the gas and the liquid phases. The proposal calls to study specifically the following: 1) The dynamics of isolated bubbles in microgravity liquid flows will be analyzed: Both the dynamics of spherical isolated bubbles and their dispersion by turbulence, their interaction with the pipe wall,the behavior of the bubbles in accelerated or decelerated flows,and the dynamics of isolated cylindrical bubbles, their deformation in accelerated/decelerated flows (in converging or diverging channels), and bubble/bubble interaction. Experiments will consist of the use of Particle Image Velocimetry (PIV) and Laser Doppler Velocimeters (LDV) to study single spherical bubble and single and two cylindrical bubble behavior with respect to their influence on the turbulence of the surrounding liquid and on the wall 2) The dynamics of bubbly and slug flow in microgravity will be analyzed especially for the role of the coalescence in the transition from bubbly to slug flow (effect of fluid properties and surfactant), to identify clusters that promote coalescence and transition the void fraction distribution in bubbly and slug flow,to measure the wall friction in bubbly flow. These experiments will consist of multiple bubbles type flows and will utilize hot wire and film anemometers to measure liquid velocity and wall shear stress respectively and double fiber optic probes to measure bubble size and velocity as a function of tube radius and axial location.

The effect of adrenaline and noradrenaline on hormone secretion and blood flow from the thyroid vein in sheep with exteriorized thyroids.

PubMed

Falconer, I R

1967-02-01

1. Emotional stimulus to the sheep has previously been shown to cause increased thyroid hormone secretion; the influence of adrenaline and noradrenaline in this process has been investigated.2. Sheep bearing exteriorized thyroid glands on carotid artery-jugular vein loops were used. Thyroid vein blood was collected through a cannula in the jugular vein within the loop, and blood flow was measured by a plethysmographic technique.3. (131)I (50 muc) was injected intramuscularly (I.M.) into the sheep, and 4-7 days later the concentration of total and protein bound (131)I in thyroid vein blood was measured in samples taken every 10 min for 4 hr. Intracarotid injections of 1 mug, I.V. injections of 5 mug, or I.V. infusions at 10 mug/min for 10 min, of adrenaline or noradrenaline were administered 1.5 hr after commencement of sampling. Blood flow from the thyroid was measured in similar experiments.4. No significant changes in thyroid hormone secretion could be attributed to adrenaline or noradrenaline, and it was concluded that circulating catecholamines do not influence the release of thyroid hormone observed after brief emotional stimulus in the sheep.

Three-Dimensional Smoothed Particle Hydrodynamics Modeling of Preferential Flow Dynamics at Fracture Intersections on a High-Performance Computing Platform

NASA Astrophysics Data System (ADS)

Kordilla, J.; Bresinsky, L. T.

2017-12-01

The physical mechanisms that govern preferential flow dynamics in unsaturated fractured rock formations are complex and not well understood. Fracture intersections may act as an integrator of unsaturated flow, leading to temporal delay, intermittent flow and partitioning dynamics. In this work, a three-dimensional Pairwise-Force Smoothed Particle Hydrodynamics (PF-SPH) model is being applied in order to simulate gravity-driven multiphase flow at synthetic fracture intersections. SPH, as a meshless Lagrangian method, is particularly suitable for modeling deformable interfaces, such as three-phase contact dynamics of droplets, rivulets and free-surface films. The static and dynamic contact angle can be recognized as the most important parameter of gravity-driven free-surface flow. In SPH, surface tension and adhesion naturally emerges from the implemented pairwise fluid-fluid (sff) and solid-fluid (ssf) interaction force. The model was calibrated to a contact angle of 65°, which corresponds to the wetting properties of water on Poly(methyl methacrylate). The accuracy of the SPH simulations were validated against an analytical solution of Poiseuille flow between two parallel plates and against laboratory experiments. Using the SPH model, the complex flow mode transitions from droplet to rivulet flow of an experimental study were reproduced. Additionally, laboratory dimensionless scaling experiments of water droplets were successfully replicated in SPH. Finally, SPH simulations were used to investigate the partitioning dynamics of single droplets into synthetic horizontal fractures with various apertures (Δdf = 0, 0.5, 1.0, 1.5, 2.0, 2.5, 3.0, 3.5, 4.0 mm) and offsets (Δdoff = -1.5, -1.0, -0.5, 0, 1.0, 2.0, 3.0 mm). Fluid masses were measured in the domains R1, R2 and R3. The perfect conditions of ideally smooth surfaces and the SPH inherent advantage of particle tracking allow the recognition of small scale partitioning mechanisms and its importance for bulk flow behavior.

Dynamic change of collateral flow varying with distribution of regional blood flow in acute ischemic rat cortex

NASA Astrophysics Data System (ADS)

Wang, Zhen; Luo, Weihua; Zhou, Fangyuan; Li, Pengcheng; Luo, Qingming

2012-12-01

Cerebral blood flow (CBF) is critical for the maintenance of cerebral function by guaranteed constant oxygen and glucose supply to brain. Collateral channels (CCs) are recruited to provide alternatives to CBF to ischemic regions once the primary vessel is occluded during ischemic stroke. However, the knowledge of the relationship between dynamic evolution of collateral flow and the distribution of regional blood flow remains limited. In this study, laser speckle imaging was used to assess dynamic changes of CCs and regional blood flow in a rat cortex with permanent middle cerebral artery occlusion (MCAo). We found that CCs immediately provided blood flow to ischemic territories after MCAo. More importantly, there were three kinds of dynamic changes of CCs during acute stroke: persistent CC, impermanent CC, and transient CC, respectively, related to different distributions of regional blood flow. Although there was the possible occurrence of peri-infarct depolarization (PID) during ischemia, there was no obvious significance about the onset time and duration of CCs between rats with and without PID. These results suggest that the initial arising of CCs does not ensure their persistence, and that collateral flow could be varied with distribution of regional blood flow in acute ischemic stroke, which may facilitate the understanding of collateral recruitment and promote the development of collateral therapeutics in the future.

Dynamic change of collateral flow varying with distribution of regional blood flow in acute ischemic rat cortex.

PubMed

Wang, Zhen; Luo, Weihua; Zhou, Fangyuan; Li, Pengcheng; Luo, Qingming

2012-12-01

Cerebral blood flow (CBF) is critical for the maintenance of cerebral function by guaranteed constant oxygen and glucose supply to brain. Collateral channels (CCs) are recruited to provide alternatives to CBF to ischemic regions once the primary vessel is occluded during ischemic stroke. However, the knowledge of the relationship between dynamic evolution of collateral flow and the distribution of regional blood flow remains limited. In this study, laser speckle imaging was used to assess dynamic changes of CCs and regional blood flow in a rat cortex with permanent middle cerebral artery occlusion (MCAo). We found that CCs immediately provided blood flow to ischemic territories after MCAo. More importantly, there were three kinds of dynamic changes of CCs during acute stroke: persistent CC, impermanent CC, and transient CC, respectively, related to different distributions of regional blood flow. Although there was the possible occurrence of peri-infarct depolarization (PID) during ischemia, there was no obvious significance about the onset time and duration of CCs between rats with and without PID. These results suggest that the initial arising of CCs does not ensure their persistence, and that collateral flow could be varied with distribution of regional blood flow in acute ischemic stroke, which may facilitate the understanding of collateral recruitment and promote the development of collateral therapeutics in the future.

Evolution of a natural debris flow: In situ measurements of flow dynamics, video imagery, and terrestrial laser scanning

USGS Publications Warehouse

McCoy, S.W.; Kean, J.W.; Coe, J.A.; Staley, D.M.; Wasklewicz, T.A.; Tucker, G.E.

2010-01-01

Many theoretical and laboratory studies have been undertaken to understand debris-flow processes and their associated hazards. However, complete and quantitative data sets from natural debris flows needed for confirmation of these results are limited. We used a novel combination of in situ measurements of debris-flow dynamics, video imagery, and pre- and postflow 2-cm-resolution digital terrain models to study a natural debris-flow event. Our field data constrain the initial and final reach morphology and key flow dynamics. The observed event consisted of multiple surges, each with clear variation of flow properties along the length of the surge. Steep, highly resistant, surge fronts of coarse-grained material without measurable pore-fluid pressure were pushed along by relatively fine-grained and water-rich tails that had a wide range of pore-fluid pressures (some two times greater than hydrostatic). Surges with larger nonequilibrium pore-fluid pressures had longer travel distances. A wide range of travel distances from different surges of similar size indicates that dynamic flow properties are of equal or greater importance than channel properties in determining where a particular surge will stop. Progressive vertical accretion of multiple surges generated the total thickness of mapped debris-flow deposits; nevertheless, deposits had massive, vertically unstratified sedimentological textures. ?? 2010 Geological Society of America.

Multiscale Particle-Based Modeling of Flowing Platelets in Blood Plasma Using Dissipative Particle Dynamics and Coarse Grained Molecular Dynamics

PubMed Central

Zhang, Peng; Gao, Chao; Zhang, Na; Slepian, Marvin J.; Deng, Yuefan; Bluestein, Danny

2014-01-01

We developed a multiscale particle-based model of platelets, to study the transport dynamics of shear stresses between the surrounding fluid and the platelet membrane. This model facilitates a more accurate prediction of the activation potential of platelets by viscous shear stresses - one of the major mechanisms leading to thrombus formation in cardiovascular diseases and in prosthetic cardiovascular devices. The interface of the model couples coarse-grained molecular dynamics (CGMD) with dissipative particle dynamics (DPD). The CGMD handles individual platelets while the DPD models the macroscopic transport of blood plasma in vessels. A hybrid force field is formulated for establishing a functional interface between the platelet membrane and the surrounding fluid, in which the microstructural changes of platelets may respond to the extracellular viscous shear stresses transferred to them. The interaction between the two systems preserves dynamic properties of the flowing platelets, such as the flipping motion. Using this multiscale particle-based approach, we have further studied the effects of the platelet elastic modulus by comparing the action of the flow-induced shear stresses on rigid and deformable platelet models. The results indicate that neglecting the platelet deformability may overestimate the stress on the platelet membrane, which in turn may lead to erroneous predictions of the platelet activation under viscous shear flow conditions. This particle-based fluid-structure interaction multiscale model offers for the first time a computationally feasible approach for simulating deformable platelets interacting with viscous blood flow, aimed at predicting flow induced platelet activation by using a highly resolved mapping of the stress distribution on the platelet membrane under dynamic flow conditions. PMID:25530818

Fluid Mechanics of Wing Adaptation for Separation Control

NASA Technical Reports Server (NTRS)

Chandrasekhara, M. S.; Wilder, M. C.; Carr, L. W.; Davis, Sanford S. (Technical Monitor)

1997-01-01

The unsteady fluid mechanics associated with use of a dynamically deforming leading edge airfoil for achieving compressible flow separation control has been experimentally studied. Changing the leading edge curvature at rapid rates dramatically alters the flow vorticity dynamics which is responsible for the many effects observed in the flow.

Lanthanide paramagnetic probes for NMR spectroscopic studies of fast molecular conformational dynamics and temperature control. Effective six-site proton exchange in 18-crown-6 by exchange spectroscopy.

PubMed

Babailov, Sergey P

2012-02-06

(1)H and (13)C NMR measurements are reported for the CDCl(3) and CD(2)Cl(2) solutions of [La(18-crown-6)(NO(3))(3)] (I), [Pr(18-crown-6) (NO(3))(3)] (II), [Ce(18-crown-6)(NO(3))(3)] (III), and [Nd(18-crown-6)(NO(3))(3)] (IV) complexes. Temperature dependencies of the (1)H NMR spectra of paramagnetic II-IV have been analyzed using the dynamic NMR (DNMR) methods for six-site exchange. Two types of conformational dynamic processes were identified (the first one is conditioned by interconversion of complex enantiomeric forms and pseudorotation of a macrocycle molecule upon the C(2) symmetry axis; the second one is conditioned by macrocycle molecule inversion). Application of exchange spectroscopy (2D-EXSY) of DNMR for investigation of this dynamic system (II-IV) simplifies the assignment of the NMR signals and represents the first experimental study of multisite exchange. In the present work, the methodology of paramagnetic 4f (Ce, Pr, and Nd) probe applications for the study of free-energy, enthalpy, and entropy changes in chemical exchange processes, as well as the advantages of this method in a comparison with DNMR studies of diamagnetic substances, is discussed. In particular, as a result of paramagnetic chemical shifts in 4f complexes, the range of measurable rate constants expands considerably compared to the analogous range in diamagnetic compounds. Coordination compounds investigated in the paper represent new types of thermometric NMR sensors and lanthanide paramagnetic probes for in situ temperature control in solution.

Nonlinear Acoustic Processes in a Solid Rocket Engine

DTIC Science & Technology

1994-03-29

conceptual framwork for the study number (M), weakly viscous internal flow sustained of solid rocket engine chamber flow dynamics which by mass...same magnitude. The formulation and results provide a conceptual framwork for the study of injected cylinder flow dynamics which supplements traditional...towards the axial direction. Until recently, conceptual understanding of this flow turning process has been based largely on the viscous properties of the

Load-Flow in Multiphase Distribution Networks: Existence, Uniqueness, Non-Singularity, and Linear Models

DOE PAGES

Bernstein, Andrey; Wang, Cong; Dall'Anese, Emiliano; ...

2018-01-01

This paper considers unbalanced multiphase distribution systems with generic topology and different load models, and extends the Z-bus iterative load-flow algorithm based on a fixed-point interpretation of the AC load-flow equations. Explicit conditions for existence and uniqueness of load-flow solutions are presented. These conditions also guarantee convergence of the load-flow algorithm to the unique solution. The proposed methodology is applicable to generic systems featuring (i) wye connections; (ii) ungrounded delta connections; (iii) a combination of wye-connected and delta-connected sources/loads; and, (iv) a combination of line-to-line and line-to-grounded-neutral devices at the secondary of distribution transformers. Further, a sufficient condition for themore » non-singularity of the load-flow Jacobian is proposed. Finally, linear load-flow models are derived, and their approximation accuracy is analyzed. Theoretical results are corroborated through experiments on IEEE test feeders.« less

Load-Flow in Multiphase Distribution Networks: Existence, Uniqueness, Non-Singularity, and Linear Models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bernstein, Andrey; Wang, Cong; Dall'Anese, Emiliano

This paper considers unbalanced multiphase distribution systems with generic topology and different load models, and extends the Z-bus iterative load-flow algorithm based on a fixed-point interpretation of the AC load-flow equations. Explicit conditions for existence and uniqueness of load-flow solutions are presented. These conditions also guarantee convergence of the load-flow algorithm to the unique solution. The proposed methodology is applicable to generic systems featuring (i) wye connections; (ii) ungrounded delta connections; (iii) a combination of wye-connected and delta-connected sources/loads; and, (iv) a combination of line-to-line and line-to-grounded-neutral devices at the secondary of distribution transformers. Further, a sufficient condition for themore » non-singularity of the load-flow Jacobian is proposed. Finally, linear load-flow models are derived, and their approximation accuracy is analyzed. Theoretical results are corroborated through experiments on IEEE test feeders.« less

Dynamic Stall of Finite Span Blades and its Control

NASA Astrophysics Data System (ADS)

Taylor, Keith; Leong, Chia; Amitay, Michael

2013-11-01

An experimental investigational study into a dynamically pitching s809 airfoil at a Reynolds number of 220,000 was conducted. Particle Image Velocimetry was employed to visualize and quantify the flow field around the airfoil. This investigation compares a 2-D configuration with 3-D configuration (i.e., a finite span blade). The difference in the flow field between these two configurations is explored, as the vibrations present in the 3-D configuration (due to the dynamic stall) may contribute to a different apparent flow field than classical results would suggest. In addition, a comparison between lift and drag coefficients, measured on the 2-D and 3-D configurations, is explored, demonstrating how time varying lift and drag forces oscillate at characteristic frequencies associated with the primary vibrational modes of the model. In addition, flow control is applied through the actuation of an array of synthetic jets located near the leading edge of the model, in order to effect changes in the flow field around the model, demonstrating how dynamic stall can be delayed or eliminated during dynamic conditions.

Global Flow Instability and Control IV Held in Crete, Greece on September 28-October 2, 2009: A Synthesis of Presentations and Discussions

DTIC Science & Technology

2009-09-01

non-uniform, stationary rotation / non- Distribution A: Approved for public release; distribution is unlimited. 8 stationary rotation , mass...Cayley spectral transformation as a means of rotating the basin of convergence of the Arnoldi algorithm. Instead of doing the inversion of the large...pair of counter rotating streamwise vortices embedded in uniform shear flow. Consistently with earlier work by the same group, the main present finding

The Effect of Dissolved Air on the Cooling Performance of a Partially Confined FC-72 Spray

DTIC Science & Technology

2008-07-01

95 iv LIST OF FIGURES Figure 1: Heat transfer coefficients: various processes and coolants ( Mudawar , 2001) .....1 Figure 2...various processes and coolants ( Mudawar , 2001). 2 In two-phase cooling a phase change of liquid to vapor, or boiling, occurs. The boiling...possible in flow boiling is also affected by the velocity of the flow and the amount of subcooling of the fluid ( Mudawar and Maddox, 1989). One highly

Increasing blood flow to exercising muscle attenuates systemic cardiovascular responses during dynamic exercise in humans

PubMed Central

Ichinose-Kuwahara, Tomoko; Kondo, Narihiko; Nishiyasu, Takeshi

2015-01-01

Reducing blood flow to working muscles during dynamic exercise causes metabolites to accumulate within the active muscles and evokes systemic pressor responses. Whether a similar cardiovascular response is elicited with normal blood flow to exercising muscles during dynamic exercise remains unknown, however. To address that issue, we tested whether cardiovascular responses are affected by increases in blood flow to active muscles. Thirteen healthy subjects performed dynamic plantarflexion exercise for 12 min at 20%, 40%, and 60% of peak workload (EX20, EX40, and EX60) with their lower thigh enclosed in a negative pressure box. Under control conditions, the box pressure was the same as the ambient air pressure. Under negative pressure conditions, beginning 3 min after the start of the exercise, the box pressure was decreased by 20, 45, and then 70 mmHg in stepwise fashion with 3-min step durations. During EX20, the negative pressure had no effect on blood flow or the cardiovascular responses measured. However, application of negative pressure increased blood flow to the exercising leg during EX40 and EX60. This increase in blood flow had no significant effect on systemic cardiovascular responses during EX40, but it markedly attenuated the pressor responses otherwise seen during EX60. These results demonstrate that during mild exercise, normal blood flow to exercising muscle is not a factor eliciting cardiovascular responses, whereas it elicits an important pressor effect during moderate exercise. This suggests blood flow to exercising muscle is a major determinant of cardiovascular responses during dynamic exercise at higher than moderate intensity. PMID:26377556

Predicting organic floc transport dynamics in shallow aquatic ecosystems: Insights from the field, the laboratory, and numerical modeling

USGS Publications Warehouse

Harvey, Judson W.; Noe, Gregory B.; Larsen, Laurel G.; Crimaldi, John P.

2009-01-01

Transport of particulate organic material can impact watershed sediment and nutrient budgets and can alter the geomorphologic evolution of shallow aquatic environments. Prediction of organic aggregate (“floc”) transport in these environments requires knowledge of how hydraulics and biota affect the entrainment, settling, and aggregation of particles. This study evaluated the aggregation and field transport dynamics of organic floc from a low‐gradient floodplain wetland with flow‐parallel ridges and sloughs in the Florida Everglades. Floc dynamics were evaluated in a rotating annular flume and in situ in the field. Under present managed conditions in the Everglades, floc is not entrained by mean flows but is suspended via biological production in the water column and bioturbation. Aggregation was a significant process affecting Everglades floc at high flume flow velocities (7.0 cm s−1) and during recovery from high flow; disaggregation was not significant for the tested flows. During moderate flows when floc dynamics are hydrodynamically controlled, it is possible to model floc transport using a single “operative floc diameter” that accurately predicts fluxes downstream and to the bed. In contrast, during high flows and recovery from high flows, aggregation dynamics should be simulated. When entrained by flow in open‐water sloughs, Everglades floc will be transported downstream in multiple deposition and reentrainment events but will undergo net settling when transported onto ridges of emergent vegetation. We hypothesize that net transport of material from open to vegetated areas during high flows is critical for forming and maintaining distinctive topographic patterning in the Everglades and other low‐gradient floodplains.

An evaluation of Dynamic TOPMODEL for low flow simulation

NASA Astrophysics Data System (ADS)

Coxon, G.; Freer, J. E.; Quinn, N.; Woods, R. A.; Wagener, T.; Howden, N. J. K.

2015-12-01

Hydrological models are essential tools for drought risk management, often providing input to water resource system models, aiding our understanding of low flow processes within catchments and providing low flow predictions. However, simulating low flows and droughts is challenging as hydrological systems often demonstrate threshold effects in connectivity, non-linear groundwater contributions and a greater influence of water resource system elements during low flow periods. These dynamic processes are typically not well represented in commonly used hydrological models due to data and model limitations. Furthermore, calibrated or behavioural models may not be effectively evaluated during more extreme drought periods. A better understanding of the processes that occur during low flows and how these are represented within models is thus required if we want to be able to provide robust and reliable predictions of future drought events. In this study, we assess the performance of dynamic TOPMODEL for low flow simulation. Dynamic TOPMODEL was applied to a number of UK catchments in the Thames region using time series of observed rainfall and potential evapotranspiration data that captured multiple historic droughts over a period of several years. The model performance was assessed against the observed discharge time series using a limits of acceptability framework, which included uncertainty in the discharge time series. We evaluate the models against multiple signatures of catchment low-flow behaviour and investigate differences in model performance between catchments, model diagnostics and for different low flow periods. We also considered the impact of surface water and groundwater abstractions and discharges on the observed discharge time series and how this affected the model evaluation. From analysing the model performance, we suggest future improvements to Dynamic TOPMODEL to improve the representation of low flow processes within the model structure.

The Dynamics of Flow and Three-dimensional Motion Around a Morphologically Complex Aquatic Plant

NASA Astrophysics Data System (ADS)

Boothroyd, R.; Hardy, R. J.; Warburton, J.; Marjoribanks, T.

2016-12-01

Aquatic vegetation has a significant impact on the hydraulic functioning of river systems. The morphology of an individual plant can influence the mean and turbulent properties of the flow, and the plant posture reconfigures to minimise drag. We report findings from a flume and numerical experiment investigating the dynamics of motion and three-dimensional flow around an isolated Hebe odora plant over a range of flow conditions. In the flume experiment, a high definition video camera recorded plant motion dynamics and three-dimensional velocity profiles were measured using an acoustic Doppler velocimeter. By producing a binary image of the plant in each frame, the plant dynamics can be quantified. Zones of greatest plant motion are on the upper and leeward sides of the plant. With increasing flow the plant is compressed and deflected downwards by up to 18% of the unstressed height. Plant tip motions are tracked and shown to lengthen with increasing flow, transitioning from horizontally dominated to vertically dominated motion. The plant acts as a porous blockage to flow, producing spatially heterogeneous downstream velocity fields with the measured wake length decreasing by 20% with increasing flow. These measurements are then used as boundary conditions and to validate a computational fluid dynamics (CFD) model. By explicitly accounting for the time-averaged plant posture, good agreement is found between flume measurements and model predictions. The flow structures demonstrate characteristics of a junction vortex system, with plant shear layer turbulence dominated by Kelvin-Helmholtz and Görtler-type vortices generated through shear instability. With increasing flow, drag coefficients decrease by up to 8%, from 1.45 to 1.34. This is equivalent to a change in the Manning's n term from 0.086 to 0.078.

Community Physician-Guided Long-Term Domiciliary Oxygen Therapy Combined With Conventional Therapy in Stage IV COPD Patients.

PubMed

Bao, Hong; Wang, Jiaman; Zhou, Ding; Han, Zhaoyong; Zhang, Yuan; Su, Ling; Ye, Xiong; Xu, Chunyan; Fu, Meihong; Li, Qinghua

The aim of the study was to explore clinical effect of community physician-guided long-term domiciliary oxygen therapy (LTDOT) on patients with Stage IV chronic obstructive pulmonary disease (COPD). A retrospective study. Fifty-four patients with Stage IV COPD were recruited and randomly divided into two groups (the LTDOT group and the control group). Patients in LTDOT group accepted additional oxygen therapy for more than 15 hours every day with continuous low flow (1-2 L/min) for 3 years. PaO2 (O2 pressure), FEV1/FVC (forced vital capacity), and FEV1% (percentage of forced expiratory volume in 1 second) in the LTDOT group increased significantly after treatment. A significant decrease was observed on the BODE index in the LTDOT group (p < .05) but not in control group (p > .05). Frequencies and costs of hospitalization therapy and emergency medical services were markedly decreased after 3 years of LTDOT. Community physician-guided LTDOT can improve prognosis and reduce the costs for stage IV COPD patients. Rehabilitation nurses can be instrumental in helping patients with stage IV COPD learn principles of LTDOT.

The Deep Crust Magmatic Refinery, Part 1: A Coupled Thermodynamic and Two-phase Flow Model

NASA Astrophysics Data System (ADS)

Riel, N., Jr.; Bouilhol, P.; Van Hunen, J.; Velic, M.; Magni, V.

2016-12-01

Metamorphic and magmatic processes occurring in the deep crust ultimately control the chemical and physical characteristic of the continental crust. A complex interplay between magma intrusion, crystallization, and reaction with the pre-existing crust provide a wide range of differentiated magma and cumulates (and / or restites) that will feed the upper crustal levels with evolved melt while constructing the lower crust. With growing evidence from field and experimental studies, it becomes clearer that crystallization and melting processes are non-exclusive but should be considered together. Incoming H2O bearing mantle melts will start to fractionate to a certain extent, forming cumulates but also releasing heat and H2O to the intruded host-rock allowing it to melt in saturated conditions. The end-result of such dynamic system is a function of the amount and composition of melt input, and extent of reaction with the host which is itself dependent on the migration mode of the melts. To assess the dynamics of this deep magmatic system we developed a new 2-D two-phase flow code using finite volume method. Our formulation takes into account: (i) melt flow through a viscous porous matrix with temperature- and melt-content dependent host-rock viscosity, (ii) heat transfer, assuming local thermal equilibrium between solid and liquid, (iii) thermodynamic modelling of stable phases, (iv) injection of fractionated melt from crystallizing basalt at the Moho and (v) chemical advection of both the solid and liquid compositions. Here we present the core of our modelling approach, especially the petrological implementation. We show in details that our thermodynamic model can reproduce well both the sub- and supra solidus phase relationship and composition of the host-rock. We apply our method to an idealized amphibolite lower crust that is affected by a magmatic event represented by the intrusion of a wet mantle melt into the crust at Moho depth. The models [see Bouilhol et al. associated abstract for results] allow calculating the different proportion of phases present in the system through time.

Dynamic CFD Simulations of the Supersonic Inflatable Aerodynamic Decelerator (SIAD) Ballistic Range Tests

NASA Technical Reports Server (NTRS)

Brock, Joseph M; Stern, Eric

2016-01-01

Dynamic CFD simulations of the SIAD ballistic test model were performed using US3D flow solver. Motivation for performing these simulations is for the purpose of validation and verification of the US3D flow solver as a viable computational tool for predicting dynamic coefficients.

Relationship between microscopic dynamics in traffic flow and complexity in networks.

PubMed

Li, Xin-Gang; Gao, Zi-You; Li, Ke-Ping; Zhao, Xiao-Mei

2007-07-01

Complex networks are constructed in the evolution process of traffic flow, and the states of traffic flow are represented by nodes in the network. The traffic dynamics can then be studied by investigating the statistical properties of those networks. According to Kerner's three-phase theory, there are two different phases in congested traffic, synchronized flow and wide moving jam. In the framework of this theory, we study different properties of synchronized flow and moving jam in relation to complex network. Scale-free network is constructed in stop-and-go traffic, i.e., a sequence of moving jams [Chin. Phys. Lett. 10, 2711 (2005)]. In this work, the networks generated in synchronized flow are investigated in detail. Simulation results show that the degree distribution of the networks constructed in synchronized flow has two power law regions, so the distinction in topological structure can really reflect the different dynamics in traffic flow. Furthermore, the real traffic data are investigated by this method, and the results are consistent with the simulations.

Technetium-99m galactosyl-neoglycoalbumin (Tc-NGA) liver imaging: Application in liver transplantation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Woodle, E.S.; Ward, R.E.; Vera, D.R.

1985-05-01

Tc-NGA is a new liver imaging agent which binds to hepatic binding protein (HBP), a hepatocyte-specific membrane receptor. The purpose of the present study was to evaluate the potential role of Tc-NGA imaging in liver transplantation. The molar Tc-NGA dose was standardized according to patient weight (0.7 nmole/kg). After a 30 minute dynamic imaging study (5 mCi, IV), kinetic analysis of time activity data (heart, liver), provided values for receptor concentration, (HBP), and hepatic blood flow, Q. Eleven Tc-NGA imaging studies were performed in transplant candidates and 22 studies were performed in seven transplant recipients. Preservation damage was manifested bymore » diffuse patchiness in tracer distribution which resolved during the following two weeks. Histologically proven, localized hepatic infarcts were demonstrated in three recipients. Lobar infarction was demonstrated in one recipient. Hepatic regeneration was later demonstrated in this patient after hepatic lobectomy. Hepatic blood flow was markedly decreased in the early postoperative period, but improved with time. Increased (HBP) was demonstrated with regeneration. Markedly decreased (HBP) and Q were obtained in several candidates who died awaiting transplantation. These studies indicate that TC-NGA liver imaging provides a valuable new means for: (1) evaluation of preservation damage, (2) early demonstration of hepatic infarction, (3) evaluation of hepatic rejection, and (4) selection of patients for hepatic transplantation.« less

Oscillations and Multiple Equilibria in Microvascular Blood Flow.

PubMed

Karst, Nathaniel J; Storey, Brian D; Geddes, John B

2015-07-01

We investigate the existence of oscillatory dynamics and multiple steady-state flow rates in a network with a simple topology and in vivo microvascular blood flow constitutive laws. Unlike many previous analytic studies, we employ the most biologically relevant models of the physical properties of whole blood. Through a combination of analytic and numeric techniques, we predict in a series of two-parameter bifurcation diagrams a range of dynamical behaviors, including multiple equilibria flow configurations, simple oscillations in volumetric flow rate, and multiple coexistent limit cycles at physically realizable parameters. We show that complexity in network topology is not necessary for complex behaviors to arise and that nonlinear rheology, in particular the plasma skimming effect, is sufficient to support oscillatory dynamics similar to those observed in vivo.

The dynamic two-fluid model OLGA; Theory and application

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bendiksen, K.H.; Maines, D.; Moe, R.

1991-05-01

Dynamic two-fluid models have found a wide range of application in the simulation of two-phase-flow systems, particularly for the analysis of steam/water flow in the core of a nuclear reactor. Until quite recently, however, very few attempts have been made to use such models in the simulation of two-phase oil and gas flow in pipelines. This paper presents a dynamic two-fluid model, OLGA, in detail, stressing the basic equations and the two-fluid models applied. Predictions of steady-state pressure drop, liquid hold-up, and flow-regime transitions are compared with data from the SINTEF Two-Phase Flow Laboratory and from the literature. Comparisons withmore » evaluated field data are also presented.« less

Characteristic Analysis and Experiment of a Dynamic Flow Balance Valve

NASA Astrophysics Data System (ADS)

Bin, Li; Song, Guo; Xuyao, Mao; Chao, Wu; Deman, Zhang; Jin, Shang; Yinshui, Liu

2017-12-01

Comprehensive characteristics of a dynamic flow balance valve of water system were analysed. The flow balance valve can change the drag efficient automatically according to the condition of system, and the effective control flowrate is constant in the range of job pressure. The structure of the flow balance valve was introduced, and the theoretical calculation formula for the variable opening of the valve core was derived. A rated pressure of 20kPa to 200kPa and a rated flowrate of 10m3/h were offered in the numerical work. Static and fluent CFX analyses show good behaviours: through the valve core structure optimization and improve design of the compressive spring, the dynamic flow balance valve can stabilize the flowrate of system evidently. And experiments show that the flow control accuracy is within 5%.

Experimental Measurements and Mathematical Modeling of Static and Dynamic Characteristics of Water Flow in a Long Pipe

NASA Astrophysics Data System (ADS)

Jablonska, J.; Kozubkova, M.

2017-08-01

Static and dynamic characteristics of flow in technical practice are very important and serious problem and can be solved by experimental measurement or mathematical modeling. Unsteady flow presents time changes of the flow and water hammer can be an example of this phenomenon. Water hammer is caused by rapid changes in the water flow by means the closure or opening of the control valve. The authors deal with by hydraulic hammer at the multiphase flow (water and air), its one-dimensional modeling (Matlab SimHydraulics) and modeling with the use of the finite volume method (Ansys Fluent) in article. The circuit elements are defined by static and dynamic characteristics. The results are verified with measurements. The article evaluates different approaches, their advantages, disadvantages and specifics in solving of water hammer.

A soft porous drop in linear flows

NASA Astrophysics Data System (ADS)

Young, Yuan-Nan; Miksis, Michael; Mori, Yoichiro; Shelley, Michael

2017-11-01

The cellular cytoplasm consists a viscous fluid filled with fibrous networks that also have their own dynamics. Such fluid-structure interactions have been modeled as a soft porous material immersed in a viscous fluid. In this talk we focus on the hydrodynamics of a viscous drop filled with soft porous material inside. Suspended in a Stokes flow, such a porous viscous drop is allowed to deform, both the drop interface and the porous structures inside. Special focus is on the deformation dynamics of both the porosity and the shape of the drop under simple flows such as a uniform streaming flow and linear flows. We examine the effects of flow boundary conditions at interface between the porous drop and the surrounding viscous fluid. We also examine the dynamics of a porous drop with active stress from the porous network.

The “focus on aneurysm” principle: Classification and surgical principles of management of concurrent arterial aneurysm with arteriovenous malformation causing intracranial hemorrhage

PubMed Central

Jha, Vikas; Behari, Sanjay; Jaiswal, Awadhesh K.; Bhaisora, Kamlesh Singh; Shende, Yogesh P.; Phadke, Rajendra V.

2016-01-01

Context: Concurrent arterial aneurysms (AAs) occurring in 2.7-16.7% patients harboring an arteriovenous malformation (AVM) aggravate the risk of intracranial hemorrhage. Aim: We evaluate the variations of aneurysms simultaneously coexisting with AVMs. A classification-based management strategy and an abbreviated nomenclature that describes their radiological features is also proposed. Setting: Tertiary care academic institute. Statistics: Test of significance applied to determine the factors causing rebleeding in the groups of patients with concurrent AVM and aneurysm and those with only AVMs. Subjects and Methods: Sixteen patients (5 with subarachnoid hemorrhage and 11 with intracerebral/intraventricular hemorrhage; 10 with low flow [LF] and 6 with high flow [HF] AVMs) underwent radiological assessment of Spetzler Martin (SM) grading and flow status of AA + AVM. Their modified Rankin's score (mRS) at admission was compared with their follow-up (F/U) score. Results: Pre-operative mRS was 0 in 5, 2 in 6, 3 in 1, 4 in 3 and 5 in 1; and, SM grade I in 5, II in 3, III in 3, IV in 4 and V in 1 patients, respectively. AA associated AVMs were classified as: (I) Flow-related proximal (n = 2); (II) flow-related distal (n = 3); (III) intranidal (n = 5); (IV) extra-intranidal (n = 2); (V) remote major ipsilateral (n = 1); (VI) remote major contralateral (n = 1); (VII) deep perforator related (n = 1); (VIII) superficial (n = 1); and (IX) distal (n = 0). Their treatment strategy included: Flow related AA, SM I-III LF AVM: aneurysm clipping with AVM excision; nidal-extranidal AA, SM I-III LF AVM: Excision or embolization of both AA + AVM; nidal-extranidal and perforator-related AA, SM IV-V HF AVM: Only endovascular embolization or radiosurgery. Surgical decision-making for remote AA took into account their ipsilateral/contralateral filling status and vessel dominance; and, for AA associated with SM III HF AVM, it varied in each patient based on diffuseness of AVM nidus, flow across arteriovenous fistula and eloquence of cortex. Follow up (F/U) (23.29 months; range: 1.5-69 months) mRS scores were 0 in 12, 2 in 2, 3 in 1 and 6 in 1 patients, respectively. Conclusions: Patients with intracranial AVMs should be screened for concurrent AAs. Further grading, management protocols and prognostication should particularly “focus on the aneurysm.” PMID:27366251

The effect of propofol infusion with topical epinephrine on cochlear blood flow and hearing: An experimental study.

PubMed

Jang, Chul Ho; Cho, Yong Beom; Lee, Jun Sik; Kim, Geun Hyung; Jung, Won-Kyo; Pak, Sok Cheon

2016-12-01

Propofol is the most commonly used intravenous (IV) anesthetic agent and is associated with hypotension upon induction of anesthesia. Intravenous propofol infusion has several properties that may be beneficial to patients undergoing middle ear surgery. Topical application of concentrated epinephrine is a valuable tool for achieving hemostasis in the middle ear and during mastoid surgery. The purpose of the present study was to determine the effects of propofol infusion with topical epinephrine on cochlear blood flow (CBF) and hearing in rats. Twenty one male Sprague-Dawley rats were divided into three groups. The rate of intravenous infusion of propofol was 4-6 ml/kg/hour. The first group (control group, n = 7) was given IV infusion of phosphate buffered saline (PBS) with topical application of PBS in the round window. In study group A (n = 7), the effect of topical phosphate buffered saline with IV infusion of propofol on CBF and hearing was evaluated. In study group B (n = 7), additional effects of topical epinephrine with IV infusion of propofol on CBF and hearing were evaluated. The laser Doppler blood flowmeter, CBF, and the mean arterial blood pressure (MAP) were measured and analyzed. Additionally, hearing test using auditory brainstem response (ABR) was performed in both groups. In both groups, infusion of propofol induced a time-dependent decrease in MAP. Approximately 30 min after the start of the propofol infusion, the CBF started to decrease slowly. The decrease in CBF was significantly greater in the study group compared to the control group. The threshold was elevated in the study group relative to the control group. During middle ear surgery, use of IV infusion of propofol with topical epinephrine cotton ball or cottonoid application is not recommended. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Dynamics of ferrofluidic flow in the Taylor-Couette system with a small aspect ratio

PubMed Central

Altmeyer, Sebastian; Do, Younghae; Lai, Ying-Cheng

2017-01-01

We investigate fundamental nonlinear dynamics of ferrofluidic Taylor-Couette flow - flow confined be-tween two concentric independently rotating cylinders - consider small aspect ratio by solving the ferro-hydrodynamical equations, carrying out systematic bifurcation analysis. Without magnetic field, we find steady flow patterns, previously observed with a simple fluid, such as those containing normal one- or two vortex cells, as well as anomalous one-cell and twin-cell flow states. However, when a symmetry-breaking transverse magnetic field is present, all flow states exhibit stimulated, finite two-fold mode. Various bifurcations between steady and unsteady states can occur, corresponding to the transitions between the two-cell and one-cell states. While unsteady, axially oscillating flow states can arise, we also detect the emergence of new unsteady flow states. In particular, we uncover two new states: one contains only the azimuthally oscillating solution in the configuration of the twin-cell flow state, and an-other a rotating flow state. Topologically, these flow states are a limit cycle and a quasiperiodic solution on a two-torus, respectively. Emergence of new flow states in addition to observed ones with classical fluid, indicates that richer but potentially more controllable dynamics in ferrofluidic flows, as such flow states depend on the external magnetic field. PMID:28059129

Dynamic Architecture Computer

DTIC Science & Technology

1988-12-01

Figures ................................... v List of Tables ................................... vi I. Introduction ..................... 1 Background... 1 Problem ................................ 3 Scope .................................. 4 Approach...Collected Data on Variables ...... 136 Appendix D: Collected Data on Operations...............208 iv List of Figures Figure Page 2- 1 Keyword Search

Stability enhancement and electronic tunability of two-dimensional SbIV compounds via surface functionalization

NASA Astrophysics Data System (ADS)

Zhou, Wenhan; Guo, Shiying; Liu, Xuhai; Cai, Bo; Song, Xiufeng; Zhu, Zhen; Zhang, Shengli

2018-01-01

We propose a family of hydrogenated- and halogenated-SbIV (SbIVX-2) materials that simultaneously have two-dimensional (2D) structures, high stability and appealing electronic properties. Based on first-principles total-energy and vibrational-spectra calculations, SbIVX-2 monolayers are found both thermally and dynamically stable. Varying IV and X elements can rationally tune the electronic properties of SbIVX-2 monolayers, effectively modulating the band gap from 0 to 3.42 eV. Regarding such superior stability and broad band-gap range, SbIVX-2 monolayers are expected to be synthesized in experiments and taken as promising candidates for low-dimensional electronic and optoelectronic devices, such as blue-to-ultraviolet light-emitting diodes (LED) and photodetectors.

Dynamic three-dimensional phase-contrast technique in MRI: application to complex flow analysis around the artificial heart valve

NASA Astrophysics Data System (ADS)

Kim, Soo Jeong; Lee, Dong Hyuk; Song, Inchang; Kim, Nam Gook; Park, Jae-Hyeung; Kim, JongHyo; Han, Man Chung; Min, Byong Goo

1998-07-01

Phase-contrast (PC) method of magnetic resonance imaging (MRI) has bee used for quantitative measurements of flow velocity and volume flow rate. It is a noninvasive technique which provides an accurate two-dimensional velocity image. Moreover, Phase Contrast Cine magnetic resonance imaging combines the flow dependent contrast of PC-MRI with the ability of cardiac cine imaging to produce images throughout the cardiac cycle. However, the accuracy of the data acquired from the single through-plane velocity encoding can be reduced by the effect of flow direction, because in many practical cases flow directions are not uniform throughout the whole region of interest. In this study, we present dynamic three-dimensional velocity vector mapping method using PC-MRI which can visualize the complex flow pattern through 3D volume rendered images displayed dynamically. The direction of velocity mapping can be selected along any three orthogonal axes. By vector summation, the three maps can be combined to form a velocity vector map that determines the velocity regardless of the flow direction. At the same time, Cine method is used to observe the dynamic change of flow. We performed a phantom study to evaluate the accuracy of the suggested PC-MRI in continuous and pulsatile flow measurement. Pulsatile flow wave form is generated by the ventricular assistant device (VAD), HEMO-PULSA (Biomedlab, Seoul, Korea). We varied flow velocity, pulsatile flow wave form, and pulsing rate. The PC-MRI-derived velocities were compared with Doppler-derived results. The velocities of the two measurements showed a significant linear correlation. Dynamic three-dimensional velocity vector mapping was carried out for two cases. First, we applied to the flow analysis around the artificial heart valve in a flat phantom. We could observe the flow pattern around the valve through the 3-dimensional cine image. Next, it is applied to the complex flow inside the polymer sac that is used as ventricle in totally implantable artificial heart (TAH). As a result we could observe the flow pattern around the valves of the sac, though complex flow can not be detected correctly in the conventional phase contrast method. In addition, we could calculate the cardiac output from TAH sac by quantitative measurement of the volume of flow across the outlet valve.

48 CFR 852.211-70 - Service data manuals.

Code of Federal Regulations, 2011 CFR

2011-10-01

... applicable, flow charts and narrative descriptions of software shall be provided. If programming is either...) Section IV, Principles of Operation. This section shall describe in narrative form the principles of... the recommended frequency of performance shall be included for visual inspection, cleaning...

USING BIOPLUME IV TO MODEL SUSTAINABILITY OF MNA

EPA Science Inventory

At most sites where Monitored Natural Attenuation (MNA) has been selected as a remedy for ground water contamination, dilution and dispersion are not the primary mechanisms responsible for attenuation along the flow path in the aquifer. In most aquifers, dilution and dispersion ...

Beam dynamics and expected performance of Sweden's new storage-ring light source: MAX IV

NASA Astrophysics Data System (ADS)

Leemann, S. C.; Andersson, Å.; Eriksson, M.; Lindgren, L.-J.; Wallén, E.; Bengtsson, J.; Streun, A.

2009-12-01

MAX IV will be Sweden’s next-generation high-performance synchrotron radiation source. The project has recently been granted funding and construction is scheduled to begin in 2010. User operation for a broad and international user community should commence in 2015. The facility is comprised of two storage rings optimized for different wavelength ranges, a linac-based short-pulse facility and a free-electron laser for the production of coherent radiation. The main radiation source of MAX IV will be a 528 m ultralow emittance storage ring operated at 3 GeV for the generation of high-brightness hard x rays. This storage ring was designed to meet the requirements of state-of-the-art insertion devices which will be installed in nineteen 5 m long dispersion-free straight sections. The storage ring is based on a novel multibend achromat design delivering an unprecedented horizontal bare lattice emittance of 0.33 nm rad and a vertical emittance below the 8 pm rad diffraction limit for 1 Å radiation. In this paper we present the beam dynamics considerations behind this storage-ring design and detail its expected unique performance.

Statistical prediction of dynamic distortion of inlet flow using minimum dynamic measurement. An application to the Melick statistical method and inlet flow dynamic distortion prediction without RMS measurements

NASA Technical Reports Server (NTRS)

Schweikhard, W. G.; Chen, Y. S.

1986-01-01

The Melick method of inlet flow dynamic distortion prediction by statistical means is outlined. A hypothetic vortex model is used as the basis for the mathematical formulations. The main variables are identified by matching the theoretical total pressure rms ratio with the measured total pressure rms ratio. Data comparisons, using the HiMAT inlet test data set, indicate satisfactory prediction of the dynamic peak distortion for cases with boundary layer control device vortex generators. A method for the dynamic probe selection was developed. Validity of the probe selection criteria is demonstrated by comparing the reduced-probe predictions with the 40-probe predictions. It is indicated that the the number of dynamic probes can be reduced to as few as two and still retain good accuracy.

International VLBI Service for Geodesy and Astrometry: General Meeting Proceedings

NASA Technical Reports Server (NTRS)

Vandenberg, Nancy R. (Editor); Baver, Karen D. (Editor)

2002-01-01

This volume contains the proceedings of the second General Meeting of the International VLBI Service for Geodesy and Astrometry (IVS), held in Tsukuba, Japan, February 4-7, 2002. The contents of this volume also appear on the IVS Web site at http://ivscc.gsfc.nasa.gov/publications/gm2002. The key-note of the second GM was prospectives for the future, in keeping with the re-organization of the IAG around the motivation of geodesy as 'an old science with a dynamic future' and noting that providing reference frames for Earth system science that are consistent over decades on the highest accuracy level will provide a challenging role for IVS. The goal of the meeting was to provide an interesting and informative program for a wide cross section of IVS members, including station operators, program managers, and analysts. This volume contains 72 papers and five abstracts of papers presented at the GM. The volume also includes reports about three splinter meetings held in conjunction with the GM: a mini-TOW (Technical Operations Workshop), the third IVS Analysis Workshop and a meeting of the analysis working group on geophysical modeling.

Subarcsecond bright points and quasi-periodic upflows below a quiescent filament observed by IRIS

NASA Astrophysics Data System (ADS)

Li, T.; Zhang, J.

2016-05-01

Context. The new Interface Region Imaging Spectrograph (IRIS) mission provides high-resolution observations of UV spectra and slit-jaw images (SJIs). These data have become available for investigating the dynamic features in the transition region (TR) below the on-disk filaments. Aims: The driver of "counter-streaming" flows along the filament spine is still unknown yet. The magnetic structures and the upflows at the footpoints of the filaments and their relations with the filament mainbody have not been well understood. We study the dynamic evolution at the footpoints of filaments in order to find some clues for solving these questions. Methods: Using UV spectra and SJIs from the IRIS, along with coronal images and magnetograms from the Solar Dynamics Observatory (SDO), we present the new features in a quiescent filament channel: subarcsecond bright points (BPs) and quasi-periodic upflows. Results: The BPs in the TR have a spatial scale of about 350-580 km and lifetimes of more than several tens of minutes. They are located at stronger magnetic structures in the filament channel with a magnetic flux of about 1017-1018 Mx. Quasi-periodic brightenings and upflows are observed in the BPs, and the period is about 4-5 min. The BP and the associated jet-like upflow comprise a "tadpole-shaped" structure. The upflows move along bright filament threads, and their directions are almost parallel to the spine of the filament. The upflows initiated from the BPs with opposite polarity magnetic fields have opposite directions. The velocity of the upflows in the plane of sky is about 5-50 km s-1. The emission line of Si IV 1402.77 Å at the locations of upflows exhibits obvious blueshifts of about 5-30 km s-1, and the line profile is broadened with the width of more than 20 km s-1. Conclusions: The BPs seem to be the bases of filament threads, and the upflows are able to convey mass for the dynamic balance of the filament. The "counter-streaming" flows in previous observations may be caused by the propagation of bi-directional upflows initiated from opposite polarity magnetic fields. We suggest that quasi-periodic brightenings of BPs and quasi-periodic upflows result from small-scale oscillatory magnetic reconnections, which are modulated by solar p-mode waves.

Interest of HYPR flow dynamic MRA for characterization of cerebral arteriovenous malformations: comparison with TRICKS MRA and catheter DSA.

PubMed

Dautry, Raphaël; Edjlali, Myriam; Roca, Pauline; Rabrait, Cécile; Wu, Yijing; Johnson, Kevin; Wieben, Olivier; Trystram, Denis; Rodriguez-Régent, Christine; Alshareef, Fawaz; Turski, Patrick; Meder, Jean-François; Naggara, Olivier; Oppenheim, Catherine

2015-11-01

HYPR flow is a 3D dynamic contrast-enhanced MRA technique providing isotropic sub-millimetre resolution with half-second temporal resolution. We compared HYPR flow and time-resolved imaging of contrast kinetics (TRICKS) MRA for the characterization of cerebral arteriovenous malformations (cAVMs), using catheter DSA as reference. Twenty-two patients underwent HYPR flow and TRICKS MRA within 15 days of DSA. HYPR flow and TRICKS datasets were reviewed separately by two readers for image quality, Spetzler-Martin grade, venous ectasia, and deep venous drainage. Image quality was better for HYPR flow than for TRICKS (narrower full width at half maximum; larger arterial diagnostic window; greater number of arterial frames, P ≤ 0.05). Using HYPR flow, inter-reader agreement was excellent for all cAVM characteristics. The agreement with DSA for the overall Spetzler-Martin grade was excellent for HYPR flow (ICC = 0.96 and 0.98, depending on the reader) and TRICKS (ICC = 0.82 and 0.95). In comparison to TRICKS, HYPR flow showed higher concordance with DSA for the identification of venous ectasia and deep venous drainage. Owing to an excellent agreement with DSA with respect to depiction of the vascular architecture of cAVMs, HYPR flow could be useful for the non-invasive characterization of cAVMs. • Dynamic MRA is used for cerebral AVM depiction and follow-up • HYPR flow is a new, highly-resolved dynamic MRA sequence • HYPR flow provides whole brain coverage • HYPR flow provides excellent agreement with the Spetzler-Martin grade • Compared to TRICKS MRA, HYPR flow improves cerebral AVM characterization.

Molecular shear heating and vortex dynamics in thermostatted two dimensional Yukawa liquids

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gupta, Akanksha; Ganesh, Rajaraman, E-mail: ganesh@ipr.res.in; Joy, Ashwin

2016-07-15

It is well known that two-dimensional macroscale shear flows are susceptible to instabilities leading to macroscale vortical structures. The linear and nonlinear fate of such a macroscale flow in a strongly coupled medium is a fundamental problem. A popular example of a strongly coupled medium is a dusty plasma, often modelled as a Yukawa liquid. Recently, laboratory experiments and molecular dynamics (MD) studies of shear flows in strongly coupled Yukawa liquids indicated the occurrence of strong molecular shear heating, which is found to reduce the coupling strength exponentially leading to the destruction of macroscale vorticity. To understand the vortex dynamicsmore » of strongly coupled molecular fluids undergoing macroscale shear flows and molecular shear heating, MD simulation has been performed, which allows the macroscopic vortex dynamics to evolve, while at the same time “removes” the microscopically generated heat without using the velocity degrees of freedom. We demonstrate that by using a configurational thermostat in a novel way, the microscale heat generated by shear flow can be thermostatted out efficiently without compromising the large scale vortex dynamics. In the present work, using MD simulations, a comparative study of shear flow evolution in Yukawa liquids in the presence and absence of molecular or microscopic heating is presented for a prototype shear flow, namely, Kolmogorov flow.« less

Advance Ratio Effects on the Dynamic-stall Vortex of a Rotating Blade in Steady Forward Flight

DTIC Science & Technology

2014-08-06

dependence on advance ratio is used to relate the stability of the dynamic-stall vortex to Coriolis effects . Advance ratio effects on the dynamic-stall vortex...relate the stability of the dynamic-stall vortex to Coriolis effects . Keywords: Leading-edge vortex, Dynamic stall vortex, Vortex flows, Rotating wing...Reynolds number are not decoupled. 3. Radial flow field In the rotating environment the coupled effect of centripetal and Coriolis accelerations is ex

Axis switching and spreading of an asymmetric jet: Role of vorticity dynamics

NASA Technical Reports Server (NTRS)

Zaman, K. B. M. Q.

1994-01-01

The effects of vortex generators and periodic excitation on vorticity dynamics and the phenomenon of axis switching in a free asymmetric jet are studied experimentally. Most of the data reported are for a 3:1 rectangular jet at a Reynolds number of 450,000 and a Mach number of 0.31. The vortex generators are in the form of 'delta tabs', triangular shaped protrusions into the flow, placed at the nozzle exit. With suitable placement of the tabs, axis switching could be either stopped or augmented. Two mechanisms are identified governing the phenomenon. One, as described by previous researchers and referred to here as the omega(sub theta)-induced dynamics, is due to difference in induced velocities for different segments of a rolled up azimuthal vortical structure. The other, omega(sub x)-induced dynamics, is due to the induced velocities of streamwise vortex pairs in the flow. Both dynamics can be active in a natural asymmetric jet; the tendency for axis switching caused by the omega(sub theta)-induced dynamics may be, depending on the streamwise vorticity distribution, either resisted or enhanced by the omega(sub x)-induced dynamics. While this simple framework qualitatively explains the various observations made on axis switching, mechanisms actually in play may be much more complex. The two dynamics are not independent as the flow field is replete with both azimuthal and streamwise vortical structures which continually interact. Phase averaged flow field data for a periodically forced case, over a volume of the flow field, are presented and discussed in an effort to gain insight into the dynamics of these vortical structures.

Efficacy of induction therapy with ATG and intravenous immunoglobulins in patients with low-level donor-specific HLA-antibodies.

PubMed

Bächler, K; Amico, P; Hönger, G; Bielmann, D; Hopfer, H; Mihatsch, M J; Steiger, J; Schaub, S

2010-05-01

Low-level donor-specific HLA-antibodies (HLA-DSA) (i.e. detectable by single-antigen flow beads, but negative by complement-dependent cytotoxicity crossmatch) represent a risk factor for early allograft rejection. The short-term efficacy of an induction regimen consisting of polyclonal anti-T-lymphocyte globulin (ATG) and intravenous immunoglobulins (IvIg) in patients with low-level HLA-DSA is unknown. In this study, we compared 67 patients with low-level HLA-DSA not having received ATG/IvIg induction (historic control) with 37 patients, who received ATG/IvIg induction. The two groups were equal regarding retransplants, HLA-matches, number and class of HLA-DSA. The overall incidence of clinical/subclinical antibody-mediated rejection (AMR) was lower in the ATG/IvIg than in the historic control group (38% vs. 55%; p = 0.03). This was driven by a significantly lower rate of clinical AMR (11% vs. 46%; p = 0.0002). Clinical T-cell-mediated rejection (TCR) was significantly lower in the ATG/IvIg than in the historic control group (0% vs. 50%; p < 0.0001). Within the first year, allograft loss due to AMR occurred in 7.5% in the historic control and in 0% in the ATG/IvIg group. We conclude that in patients with low-level HLA-DSA, ATG/IvIg induction significantly reduces TCR and the severity of AMR, but the high rate of subclinical AMR suggests an insufficient control of the humoral immune response.

Influence of Marangoni flows on the dynamics of isothermal A + B → C reaction fronts.

PubMed

Tiani, R; Rongy, L

2016-09-28

The nonlinear dynamics of A + B → C fronts is analyzed both numerically and theoretically in the presence of Marangoni flows, i.e., convective motions driven by surface tension gradients. We consider horizontal aqueous solutions where the three species A, B, and C can affect the surface tension of the solution, thereby driving Marangoni flows. The resulting dynamics is studied by numerically integrating the incompressible Navier-Stokes equations coupled to reaction-diffusion-convection (RDC) equations for the three chemical species. We show that the dynamics of the front cannot be predicted solely on the basis of the one-dimensional reaction-diffusion profiles as is the case for buoyancy-driven convection around such fronts. We relate this observation to the structure of Marangoni flows which lead to more complex and exotic dynamics. We find in particular the surprising possibility of a reversal of the front propagation direction in time for some sets of Marangoni numbers, quantifying the influence of each chemical species concentration on the solution surface tension. We explain this reversal analytically and propose a new classification of the convective effects on A + B → C reaction fronts as a function of the Marangoni numbers. The influence of the layer thickness on the RDC dynamics is also presented. Those results emphasize the importance of flow symmetry properties when studying convective front dynamics in a given geometry.

Non-linear dynamics and alternating 'flip' solutions in ferrofluidic Taylor-Couette flow

NASA Astrophysics Data System (ADS)

Altmeyer, Sebastian

2018-04-01

This study treats with the influence of a symmetry-breaking transversal magnetic field on the nonlinear dynamics of ferrofluidic Taylor-Couette flow - flow confined between two concentric independently rotating cylinders. We detected alternating 'flip' solutions which are flow states featuring typical characteristics of slow-fast-dynamics in dynamical systems. The flip corresponds to a temporal change in the axial wavenumber and we find them to appear either as pure 2-fold axisymmetric (due to the symmetry-breaking nature of the applied transversal magnetic field) or involving non-axisymmetric, helical modes in its interim solution. The latter ones show features of typical ribbon solutions. In any case the flip solutions have a preferential first axial wavenumber which corresponds to the more stable state (slow dynamics) and second axial wavenumber, corresponding to the short appearing more unstable state (fast dynamics). However, in both cases the flip time grows exponential with increasing the magnetic field strength before the flip solutions, living on 2-tori invariant manifolds, cease to exist, with lifetime going to infinity. Further we show that ferrofluidic flow turbulence differ from the classical, ordinary (usually at high Reynolds number) turbulence. The applied magnetic field hinders the free motion of ferrofluid partials and therefore smoothen typical turbulent quantities and features so that speaking of mildly chaotic dynamics seems to be a more appropriate expression for the observed motion.

The effect of leading edge tubercles on dynamic stall

NASA Astrophysics Data System (ADS)

Hrynuk, John

The effect of the leading edge tubercles of humpback whales has been heavily studied for their static benefits. These studies have shown that tubercles inhibit flow separation, limit spanwise flow, and extend the operating angle of a wing beyond the static stall point while maintaining lift, all while having a comparatively low negative impact on drag. The current study extends the prior work to investigating the effect of tubercles on dynamic stall, a fundamental flow phenomenon that occurs when wings undergo dynamic pitching motions. Flow fields around the wing models tested were studied using Laser Induced Fluorescence (LIF) and Molecular Tagging Velocimetry (MTV).Resulting velocity fields show that the dynamics of the formation and separation of the leading edge vortex were fundamentally different between the straight wing and the tubercled wing. Tracking of the Dynamic Stall Vortex (DSV) and Shear Layer Vortices (SLVs), which may have a significant impact on the overall flow behavior, was done along with calculations of vortex circulation. Proximity to the wing surface and total circulation were used to evaluate potential dynamic lift increases provided by the tubercles. The effects of pitch rate on the formation process and benefits of the tubercles were also studied and were generally consistent with prior dynamic stall studies. However, tubercles were shown to affect the SLV formation and the circulation differently at higher pitch rates.

Laser speckle contrast imaging of collateral blood flow during acute ischemic stroke

PubMed Central

Armitage, Glenn A; Todd, Kathryn G; Shuaib, Ashfaq; Winship, Ian R

2010-01-01

Collateral vasculature may provide an alternative route for blood flow to reach the ischemic tissue and partially maintain oxygen and nutrient support during ischemic stroke. However, much about the dynamics of stroke-induced collateralization remains unknown. In this study, we used laser speckle contrast imaging to map dynamic changes in collateral blood flow after middle cerebral artery occlusion in rats. We identified extensive anastomatic connections between the anterior and middle cerebral arteries that develop after vessel occlusion and persist for 24 hours. Augmenting blood flow through these persistent yet dynamic anastomatic connections may be an important but relatively unexplored avenue in stroke therapy. PMID:20517321

Gravity-driven soap film dynamics in subcritical regimes

NASA Astrophysics Data System (ADS)

Auliel, M. I.; Castro, F.; Sosa, R.; Artana, G.

2015-10-01

We undertake the analysis of soap-film dynamics with the classical approach of asymptotic expansions. We focus our analysis in vertical soap film tunnels operating in subcritical regimes with elastic Mach numbers Me=O(10-1) . Considering the associated set of nondimensional numbers that characterize this flow, we show that the flow behaves as a two-dimensional (2D) divergence free flow with variable mass density. When the soap film dynamics agrees with that of a 2D and almost constant mass density flow, the regions where the second invariant of the velocity gradient is non-null correspond to regions where the rate of change of film thickness is non-negligible.

Transcranial Doppler-determined change in posterior cerebral artery blood flow velocity does not reflect vertebral artery blood flow during exercise.

PubMed

Washio, Takuro; Sasaki, Hiroyuki; Ogoh, Shigehiko

2017-04-01

We examined whether a change in posterior cerebral artery flow velocity (PCAv) reflected the posterior cerebral blood flow in healthy subjects during both static and dynamic exercise. PCAv and vertebral artery (VA) blood flow, as an index of posterior cerebral blood flow, were continuously measured during an exercise trial using transcranial Doppler (TCD) ultrasonography and Doppler ultrasound, respectively. Static handgrip exercise significantly increased both PCAv and VA blood flow. Increasing intensity of dynamic exercise further increased VA blood flow from moderate exercise, while PCAv decreased to almost resting level. During both static and dynamic exercise, the PCA cerebrovascular conductance (CVC) index significantly decreased from rest (static and high-intensity dynamic exercise, -11.5 ± 12.2% and -18.0 ± 16.8%, means ± SD, respectively) despite no change in the CVC of VA. These results indicate that vasoconstriction occurred at PCA but not VA during exercise-induced hypertension. This discrepancy in vascular response to exercise between PCA and VA may be due to different cerebral arterial characteristics. Therefore, to determine the effect of exercise on posterior cerebral circulation, at least, we need to carefully consider which cerebral artery to measure, regardless of exercise mode. NEW & NOTEWORTHY We examined whether transcranial Doppler-determined flow velocity in the posterior cerebral artery can be used as an index of cerebral blood flow during exercise. However, the changes in posterior cerebral artery flow velocity during exercise do not reflect vertebral artery blood flow. Copyright © 2017 the American Physiological Society.

Percolation transition in dynamical traffic network with evolving critical bottlenecks.

PubMed

Li, Daqing; Fu, Bowen; Wang, Yunpeng; Lu, Guangquan; Berezin, Yehiel; Stanley, H Eugene; Havlin, Shlomo

2015-01-20

A critical phenomenon is an intrinsic feature of traffic dynamics, during which transition between isolated local flows and global flows occurs. However, very little attention has been given to the question of how the local flows in the roads are organized collectively into a global city flow. Here we characterize this organization process of traffic as "traffic percolation," where the giant cluster of local flows disintegrates when the second largest cluster reaches its maximum. We find in real-time data of city road traffic that global traffic is dynamically composed of clusters of local flows, which are connected by bottleneck links. This organization evolves during a day with different bottleneck links appearing in different hours, but similar in the same hours in different days. A small improvement of critical bottleneck roads is found to benefit significantly the global traffic, providing a method to improve city traffic with low cost. Our results may provide insights on the relation between traffic dynamics and percolation, which can be useful for efficient transportation, epidemic control, and emergency evacuation.

Resolution of Large Azygos Vein Aneurysm Following Stent-Graft Shunt Placement in a Patient with Ehlers-Danlos Syndrome Type IV

DOE Office of Scientific and Technical Information (OSTI.GOV)

D'Souza, Estelle S.; Williams, David M.; Deeb, G.M.

2006-10-15

Ehlers-Danlos syndrome (EDS) type IV is a rare connective tissue disorder associated with thin-walled, friable arteries and veins predisposing patients to aneurysm formation, dissection, fistula formation, and vessel rupture. Azygos vein aneurysm is an extremely rare condition which has not been reported in association with EDS in the literature. We present a patient with EDS type IV and interrupted inferior vena cava (IVC) with azygos continuation who developed an azygos vein aneurysm. In order to decrease flow through the azygos vein and reduce the risk of aneurysm rupture, a stent-graft shunt was created from the right hepatic vein to themore » azygos vein via a transhepatic, retroperitoneal route. At 6 month follow-up the shunt was open and the azygos vein aneurysm had resolved.« less

Characterization of Flow Dynamics and Reduced-Order Description of Experimental Two-Phase Pipe Flow

NASA Astrophysics Data System (ADS)

Viggiano, Bianca; SkjæRaasen, Olaf; Tutkun, Murat; Cal, Raul Bayoan

2017-11-01

Multiphase pipe flow is investigated using proper orthogonal decomposition for tomographic X-ray data, where holdup, cross sectional phase distributions and phase interface characteristics are obtained. Instantaneous phase fractions of dispersed flow and slug flow are analyzed and a reduced order dynamical description is generated. The dispersed flow displays coherent structures in the first few modes near the horizontal center of the pipe, representing the liquid-liquid interface location while the slug flow case shows coherent structures that correspond to the cyclical formation and breakup of the slug in the first 10 modes. The reconstruction of the fields indicate that main features are observed in the low order dynamical descriptions utilizing less than 1 % of the full order model. POD temporal coefficients a1, a2 and a3 show interdependence for the slug flow case. The coefficients also describe the phase fraction holdup as a function of time for both dispersed and slug flow. These flows are highly applicable to petroleum transport pipelines, hydroelectric power and heat exchanger tubes to name a few. The mathematical representations obtained via proper orthogonal decomposition will deepen the understanding of fundamental multiphase flow characteristics.

Towards DMD-Based Estimation and Control of Flow Separation using an Array of Surface Pressure Sensors

NASA Astrophysics Data System (ADS)

Deem, Eric; Cattafesta, Louis; Zhang, Hao; Rowley, Clancy

2016-11-01

Closed-loop control of flow separation requires the spatio-temporal states of the flow to be fed back through the controller in real time. Previously, static and dynamic estimation methods have been employed that provide reduced-order model estimates of the POD-coefficients of the flow velocity using surface pressure measurements. However, this requires a "learning" dataset a priori. This approach is effective as long as the dynamics during control do not stray from the learning dataset. Since only a few dynamical features are required for feedback control of flow separation, many of the details provided by full-field snapshots are superfluous. This motivates a state-observation technique that extracts key dynamical features directly from surface pressure, without requiring PIV snapshots. The results of identifying DMD modes of separated flow through an array of surface pressure sensors in real-time are presented. This is accomplished by employing streaming DMD "on the fly" to surface pressure snapshots. These modal characteristics exhibit striking similarities to those extracted from PIV data and the pressure field obtained via solving Poisson's equation. Progress towards closed-loop separation control based on the dynamic modes of surface pressure will be discussed. Supported by AFOSR Grant FA9550-14-1-0289.

Assessment of variables controlling nitrate dynamics in groundwater: is it a threat to surface aquatic ecosystems?

PubMed

Rasiah, V; Armour, J D; Cogle, A L

2005-01-01

The impact of fertilised cropping on nitrate-N dynamics in groundwater (GW) was assessed in a catchment from piezometers installed: (i) to different depths, (ii) in different soil types, (iii) on different positions on landscape, and (iv) compared with the Australian and New Zealand Environmental and Conservation Council guideline values provided for different aquatic ecosystems. The GW and NO(3)-N concentration dynamics were monitored in 39 piezometer wells, installed to 5-90 m depth, under fertilized sugarcane (Saccharum officinarum-S) in the Johnstone River Catchment, Australia, from 1999 January through September 2002. The median nitrate-N concentration ranged from 14 to 1511 microg L(-1), and the 80th percentile from 0 to 1341 microg L(-1). In 34 out of the 39 piezometer wells the 80th percentile or 80% of the nitrate-N values were higher than 30 microg L(-1), which is the maximum trigger value provided in the ANZECC table for sustainable health of different aquatic ecosystems. Nitrate-N concentration decreased with increasing well depth, increasing depth of water in wells, and with decreasing relief on landscape. Nitrate-N was higher in alluvial soil profiles than on those formed in-situ. Nitrate-N increased with increasing rainfall at the beginning of the rainy season, fluctuated during the peak rainy period, and then decreased when the rain ceased. The rapid decrease in GW after the rains ceased suggested potential existed for nitrate-N to be discharged as lateral-flow into streams. This may contribute towards the deterioration in the health of down-stream aquatic ecosystems.

[Ultraviolet spectroscopic study on the fine structures in the solar polar hole].

PubMed

Zhang, Min; Wang, Dong; Liu, Guo-Hong

2014-07-01

Fine structures in the south solar polar coronal hole were observed by N IV line of SOHO/SUMER spectrograph. The scales of the fine structures range spatially range from 1 arcsec to several arcsecs, temporally from 1 min to several minutes, and parts of them are in strip shape along the slit direction. The line-of-sight velocity of them is up to tens of km x s(-1) with red and blue shift intercrossed occasionally, which appear periodically as long as 100 minutes in some regions. Part of the fine structures can be clearly observed at the Ne V III line with higher formation temperature in the same spectral window. The time and location of some fine structures with high velocity in the Ne V III spectrum are almost the same as that in N IV spectrum, but they are extended and diffused in the Ne V III spectrum. Some fine structures have non-Gaussian profiles with the line-of-sight Doppler velocities up to 150 km x s(-1) in the N IV blue/red wings, which is similar with the explosive events in the transition region. In the past, explosive events are small-scale dynamic phenomena often observed in the quiet-sun (QS) region, while their properties in coronal holes (CHs) remain unclear. Here, we find the EE-like events with strong dynamics in the south solar polar coronal hole by N IV line of SOHO/SUMER spectrograph.

Lava Flow Dynamics

NASA Technical Reports Server (NTRS)

Taylor, G. Jeffrey

1996-01-01

This grant originally had four major tasks, all of which were addressed to varying extents during the course of the research: (1) Measure the fractal dimensions of lava flows as a function of topography, substrate, and rheology; (2) The nature of lava tube systems and their relation to flow fields; (3) A quantitative assessment of lava flow dynamics in light of the fractal nature of lava flow margins; and (4) Development and application of a new remote sensing tool based on fractal properties. During the course of the research, the project expanded to include the following projects: (1) A comparison of what we can-learn from remote sensing studies of lava flow morphology and from studies of samples of lava flows; (2) Study of a terrestrial analog of the nakhlites, one of the groups of meteorites from Mars; and (3) Study of the textures of Hawaiian basalts as an aid in understanding the dynamics (flow rates, inflation rates, thermal history) of flow interiors. In addition, during the first year an educational task (development and writing of a teacher's guide and activity set to accompany the lunar sample disk when it is sent to schools) was included.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Na; Zhang, Peng; Kang, Wei

Multiscale simulations of fluids such as blood represent a major computational challenge of coupling the disparate spatiotemporal scales between molecular and macroscopic transport phenomena characterizing such complex fluids. In this paper, a coarse-grained (CG) particle model is developed for simulating blood flow by modifying the Morse potential, traditionally used in Molecular Dynamics for modeling vibrating structures. The modified Morse potential is parameterized with effective mass scales for reproducing blood viscous flow properties, including density, pressure, viscosity, compressibility and characteristic flow dynamics of human blood plasma fluid. The parameterization follows a standard inverse-problem approach in which the optimal micro parameters aremore » systematically searched, by gradually decoupling loosely correlated parameter spaces, to match the macro physical quantities of viscous blood flow. The predictions of this particle based multiscale model compare favorably to classic viscous flow solutions such as Counter-Poiseuille and Couette flows. It demonstrates that such coarse grained particle model can be applied to replicate the dynamics of viscous blood flow, with the advantage of bridging the gap between macroscopic flow scales and the cellular scales characterizing blood flow that continuum based models fail to handle adequately.« less

Flow dynamics analyses of pathophysiological liver lobules using porous media theory

NASA Astrophysics Data System (ADS)

Hu, Jinrong; Lü, Shouqin; Feng, Shiliang; Long, Mian

2017-08-01

Blood flow inside the liver plays a key role in hepatic functions, and abnormal hemodynamics are highly correlated with liver diseases. To date, the flow field in an elementary building block of the organ, the liver lobule, is difficult to determine experimentally in humans due to its complicated structure, with radially branched microvasculature and the technical difficulties that derive from its geometric constraints. Here we established a set of 3D computational models for a liver lobule using porous media theory and analyzed its flow dynamics in normal, fibrotic, and cirrhotic lobules. Our simulations indicated that those approximations of ordinary flow in portal tracts (PTs) and the central vein, and of porous media flow in the sinusoidal network, were reasonable only for normal or fibrotic lobules. Models modified with high resistance in PTs and collateral vessels inside sinusoids were able to describe the flow features in cirrhotic lobules. Pressures, average velocities, and volume flow rates were profiled and the predictions compared well with experimental data. This study furthered our understanding of the flow dynamics features of liver lobules and the differences among normal, fibrotic, and cirrhotic lobules.

Abundance, size distributions and trace-element binding of organic and iron-rich nanocolloids in Alaskan rivers, as revealed by field-flow fractionation and ICP-MS

NASA Astrophysics Data System (ADS)

Stolpe, Björn; Guo, Laodong; Shiller, Alan M.; Aiken, George R.

2013-03-01

Water samples were collected from six small rivers in the Yukon River basin in central Alaska to examine the role of colloids and organic matter in the transport of trace elements in Northern high latitude watersheds influenced by permafrost. Concentrations of dissolved organic carbon (DOC), selected elements (Al, Si, Ca, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Rb, Sr, Ba, Pb, U), and UV-absorbance spectra were measured in 0.45 μm filtered samples. 'Nanocolloidal size distributions' (0.5-40 nm, hydrodynamic diameter) of humic-type and chromophoric dissolved organic matter (CDOM), Cr, Mn, Fe, Co, Ni, Cu, Zn, and Pb were determined by on-line coupling of flow field-flow fractionation (FFF) to detectors including UV-absorbance, fluorescence, and ICP-MS. Total dissolved and nanocolloidal concentrations of the elements varied considerably between the rivers and between spring flood and late summer base flow. Data on specific UV-absorbance (SUVA), spectral slopes, and the nanocolloidal fraction of the UV-absorbance indicated a decrease in aromaticity and size of CDOM from spring flood to late summer. The nanocolloidal size distributions indicated the presence of different 'components' of nanocolloids. 'Fulvic-rich nanocolloids' had a hydrodynamic diameter of 0.5-3 nm throughout the sampling season; 'organic/iron-rich nanocolloids' occurred in the <8 nm size range during the spring flood; whereas 'iron-rich nanocolloids' formed a discrete 4-40 nm components during summer base flow. Mn, Co, Ni, Cu and Zn were distributed between the nanocolloid components depending on the stability constant of the metal (+II)-organic complexes, while stronger association of Cr to the iron-rich nanocolloids was attributed to the higher oxidation states of Cr (+III or +IV). Changes in total dissolved element concentrations, size and composition of CDOM, and occurrence and size of organic/iron and iron-rich nanocolloids were related to variations in their sources from either the upper organic-rich soil or the deeper mineral layer, depending on seasonal variations in hydrological flow patterns and permafrost dynamics.

Vibrational dynamics (IR, Raman, NRVS) and DFT study of new antitumor tetranuclearstannoxanecluster, Sn(IV)$-$oxo$-$${di$$-$o$-$vanillin} dimethyl dichloride

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arjmand, F.; Sharma, S.; Usman, M.

2016-06-21

The vibrational dynamics of a newly synthesized tetrastannoxane was characterized with a combination of experimental (Raman, IR and tin-based nuclear resonance vibrational spectroscopy) and computational (DFT/B3LYP) methods, with an emphasis on the vibrations of the tin sites. The cytotoxic activity revealed a significant regression selectively against the human pancreatic cell lines.

Control of unsteady separated flow associated with the dynamic stall of airfoils

NASA Technical Reports Server (NTRS)

Wilder, Michael C.

1992-01-01

The two principal objectives of this research were to achieve an improved understanding of the mechanisms involved in the onset and development of dynamic stall under compressible flow conditions, and to investigate the feasibility of employing adaptive airfoil geometry as an active flow control device in the dynamic stall engine. Presented here are the results of a quantitative (PDI) study of the compressibility effects on dynamic stall over the transiently pitching airfoil, as well as a discussion of a preliminary technique developed to measure the deformation produced by the adaptive geometry control device, and bench test results obtained using an airfoil equipped with the device.

Dynamic hydro-climatic networks in pristine and regulated rivers

NASA Astrophysics Data System (ADS)

Botter, G.; Basso, S.; Lazzaro, G.; Doulatyari, B.; Biswal, B.; Schirmer, M.; Rinaldo, A.

2014-12-01

Flow patterns observed at-a-station are the dynamical byproduct of a cascade of processes involving different compartments of the hydro-climatic network (e.g., climate, rainfall, soil, vegetation) that regulates the transformation of rainfall into streamflows. In complex branching rivers, flow regimes result from the heterogeneous arrangement around the stream network of multiple hydrologic cascades that simultaneously occur within distinct contributing areas. As such, flow regimes are seen as the integrated output of a complex "network of networks", which can be properly characterized by its degree of temporal variability and spatial heterogeneity. Hydrologic networks that generate river flow regimes are dynamic in nature. In pristine rivers, the time-variance naturally emerges at multiple timescales from climate variability (namely, seasonality and inter-annual fluctuations), implying that the magnitude (and the features) of the water flow between two nodes may be highly variable across different seasons and years. Conversely, the spatial distribution of river flow regimes within pristine rivers involves scale-dependent transport features, as well as regional climatic and soil use gradients, which in small and meso-scale catchments (A < 103 km2) are usually mild enough to guarantee quite uniform flow regimes and high spatial correlations. Human-impacted rivers, instead, constitute hybrid networks where observed spatio-temporal patterns are dominated by anthropogenic shifts, such as landscape alterations and river regulation. In regulated rivers, the magnitude and the features of water flows from node to node may change significantly through time due to damming and withdrawals. However, regulation may impact river regimes in a spatially heterogeneous manner (e.g. in localized river reaches), with a significant decrease of spatial correlations and network connectivity. Provided that the spatial and temporal dynamics of flow regimes in complex rivers may strongly impact important biotic processes involved in the river food web (e.g. biofilm and riparian vegetation dynamics), the study of rivers as dynamic networks provides important clues to water management strategies and freshwater ecosystem studies.

Mode decomposition and Lagrangian structures of the flow dynamics in orbitally shaken bioreactors

NASA Astrophysics Data System (ADS)

Weheliye, Weheliye Hashi; Cagney, Neil; Rodriguez, Gregorio; Micheletti, Martina; Ducci, Andrea

2018-03-01

In this study, two mode decomposition techniques were applied and compared to assess the flow dynamics in an orbital shaken bioreactor (OSB) of cylindrical geometry and flat bottom: proper orthogonal decomposition and dynamic mode decomposition. Particle Image Velocimetry (PIV) experiments were carried out for different operating conditions including fluid height, h, and shaker rotational speed, N. A detailed flow analysis is provided for conditions when the fluid and vessel motions are in-phase (Fr = 0.23) and out-of-phase (Fr = 0.47). PIV measurements in vertical and horizontal planes were combined to reconstruct low order models of the full 3D flow and to determine its Finite-Time Lyapunov Exponent (FTLE) within OSBs. The combined results from the mode decomposition and the FTLE fields provide a useful insight into the flow dynamics and Lagrangian coherent structures in OSBs and offer a valuable tool to optimise bioprocess design in terms of mixing and cell suspension.

Numerical modeling of turbulent swirling flow in a multi-inlet vortex nanoprecipitation reactor using dynamic DDES

NASA Astrophysics Data System (ADS)

Hill, James C.; Liu, Zhenping; Fox, Rodney O.; Passalacqua, Alberto; Olsen, Michael G.

2015-11-01

The multi-inlet vortex reactor (MIVR) has been developed to provide a platform for rapid mixing in the application of flash nanoprecipitation (FNP) for manufacturing functional nanoparticles. Unfortunately, commonly used RANS methods are unable to accurately model this complex swirling flow. Large eddy simulations have also been problematic, as expensive fine grids to accurately model the flow are required. These dilemmas led to the strategy of applying a Delayed Detached Eddy Simulation (DDES) method to the vortex reactor. In the current work, the turbulent swirling flow inside a scaled-up MIVR has been investigated by using a dynamic DDES model. In the DDES model, the eddy viscosity has a form similar to the Smagorinsky sub-grid viscosity in LES and allows the implementation of a dynamic procedure to determine its coefficient. The complex recirculating back flow near the reactor center has been successfully captured by using this dynamic DDES model. Moreover, the simulation results are found to agree with experimental data for mean velocity and Reynolds stresses.

Stochastic ice stream dynamics

PubMed Central

Bertagni, Matteo Bernard; Ridolfi, Luca

2016-01-01

Ice streams are narrow corridors of fast-flowing ice that constitute the arterial drainage network of ice sheets. Therefore, changes in ice stream flow are key to understanding paleoclimate, sea level changes, and rapid disintegration of ice sheets during deglaciation. The dynamics of ice flow are tightly coupled to the climate system through atmospheric temperature and snow recharge, which are known exhibit stochastic variability. Here we focus on the interplay between stochastic climate forcing and ice stream temporal dynamics. Our work demonstrates that realistic climate fluctuations are able to (i) induce the coexistence of dynamic behaviors that would be incompatible in a purely deterministic system and (ii) drive ice stream flow away from the regime expected in a steady climate. We conclude that environmental noise appears to be crucial to interpreting the past behavior of ice sheets, as well as to predicting their future evolution. PMID:27457960

Discrete Adjoint-Based Design Optimization of Unsteady Turbulent Flows on Dynamic Unstructured Grids

NASA Technical Reports Server (NTRS)

Nielsen, Eric J.; Diskin, Boris; Yamaleev, Nail K.

2009-01-01

An adjoint-based methodology for design optimization of unsteady turbulent flows on dynamic unstructured grids is described. The implementation relies on an existing unsteady three-dimensional unstructured grid solver capable of dynamic mesh simulations and discrete adjoint capabilities previously developed for steady flows. The discrete equations for the primal and adjoint systems are presented for the backward-difference family of time-integration schemes on both static and dynamic grids. The consistency of sensitivity derivatives is established via comparisons with complex-variable computations. The current work is believed to be the first verified implementation of an adjoint-based optimization methodology for the true time-dependent formulation of the Navier-Stokes equations in a practical computational code. Large-scale shape optimizations are demonstrated for turbulent flows over a tiltrotor geometry and a simulated aeroelastic motion of a fighter jet.

International Neural Network Society Annual Meeting (1994) Held in San Diego, California on 5-9 June 1994. Volume 3.

DTIC Science & Technology

1994-06-09

Competitive Neural Nets Speed Complex Fluid Flow Calculations 1-366 T. Long, E. Hanzevack Neural Networks for Steam Boiler MIMO Modeling and Advisory Control...Gallinr The Cochlear Nucleus and Primary Cortex as a Sequence of Distributed Neural Filters in Phoneme IV-607 Perception J. Antrobus, C. Tarshish, S...propulsion linear model, a fuel flow actuator modelled as a linear second order system with position and rate limits, and a thrust vectoring actuator

Electromagnetic Flow Meter Having a Driver Circuit Including a Current Transducer

NASA Technical Reports Server (NTRS)

Patel, Sandeep K. (Inventor); Karon, David M. (Inventor); Cushing, Vincent (Inventor)

2014-01-01

An electromagnetic flow meter (EMFM) accurately measures both the complete flow rate and the dynamically fluctuating flow rate of a fluid by applying a unipolar DC voltage to excitation coils for a predetermined period of time, measuring the electric potential at a pair of electrodes, determining a complete flow rate and independently measuring the dynamic flow rate during the "on" cycle of the DC excitation, and correcting the measurements for errors resulting from galvanic drift and other effects on the electric potential. The EMFM can also correct for effects from the excitation circuit induced during operation of the EMFM.

Numerical analysis of laminar and turbulent incompressible flows using the finite element Fluid Dynamics Analysis Package (FIDAP)

NASA Technical Reports Server (NTRS)

Sohn, Jeong L.

1988-01-01

The purpose of the study is the evaluation of the numerical accuracy of FIDAP (Fluid Dynamics Analysis Package). Accordingly, four test problems in laminar and turbulent incompressible flows are selected and the computational results of these problems compared with other numerical solutions and/or experimental data. These problems include: (1) 2-D laminar flow inside a wall-driven cavity; (2) 2-D laminar flow over a backward-facing step; (3) 2-D turbulent flow over a backward-facing step; and (4) 2-D turbulent flow through a turn-around duct.

Nocturnal Near-Surface Temperature, but not Flow Dynamics, can be Predicted by Microtopography in a Mid-Range Mountain Valley

NASA Astrophysics Data System (ADS)

Pfister, Lena; Sigmund, Armin; Olesch, Johannes; Thomas, Christoph K.

2017-11-01

We investigate nocturnal flow dynamics and temperature behaviour near the surface of a 170-m long gentle slope in a mid-range mountain valley. In contrast to many existing studies focusing on locations with significant topographic variations, gentle slopes cover a greater spatial extent of the Earth's surface. Air temperatures were measured using the high-resolution distributed-temperature-sensing method within a two-dimensional fibre-optic array in the lowest metre above the surface. The main objectives are to characterize the spatio-temporal patterns in the near-surface temperature and flow dynamics, and quantify their responses to the microtopography and land cover. For the duration of the experiment, including even clear-sky nights with weak winds and strong radiative forcing, the classical cold-air drainage predicted by theory could not be detected. In contrast, we show that the airflow for the two dominant flow modes originates non-locally. The most abundant flow mode is characterized by vertically-decoupled layers featuring a near-surface flow perpendicular to the slope and strong stable stratification, which contradicts the expectation of a gravity-driven downslope flow of locally produced cold air. Differences in microtopography and land cover clearly affect spatio-temporal temperature perturbations. The second most abundant flow mode is characterized by strong mixing, leading to vertical coupling with airflow directed down the local slope. Here variations of microtopography and land cover lead to negligible near-surface temperature perturbations. We conclude that spatio-temporal temperature perturbations, but not flow dynamics, can be predicted by microtopography, which complicates the prediction of advective-heat components and the existence and dynamics of cold-air pools in gently sloped terrain in the absence of observations.

Increasing blood flow to exercising muscle attenuates systemic cardiovascular responses during dynamic exercise in humans.

PubMed

Ichinose, Masashi; Ichinose-Kuwahara, Tomoko; Kondo, Narihiko; Nishiyasu, Takeshi

2015-11-15

Reducing blood flow to working muscles during dynamic exercise causes metabolites to accumulate within the active muscles and evokes systemic pressor responses. Whether a similar cardiovascular response is elicited with normal blood flow to exercising muscles during dynamic exercise remains unknown, however. To address that issue, we tested whether cardiovascular responses are affected by increases in blood flow to active muscles. Thirteen healthy subjects performed dynamic plantarflexion exercise for 12 min at 20%, 40%, and 60% of peak workload (EX20, EX40, and EX60) with their lower thigh enclosed in a negative pressure box. Under control conditions, the box pressure was the same as the ambient air pressure. Under negative pressure conditions, beginning 3 min after the start of the exercise, the box pressure was decreased by 20, 45, and then 70 mmHg in stepwise fashion with 3-min step durations. During EX20, the negative pressure had no effect on blood flow or the cardiovascular responses measured. However, application of negative pressure increased blood flow to the exercising leg during EX40 and EX60. This increase in blood flow had no significant effect on systemic cardiovascular responses during EX40, but it markedly attenuated the pressor responses otherwise seen during EX60. These results demonstrate that during mild exercise, normal blood flow to exercising muscle is not a factor eliciting cardiovascular responses, whereas it elicits an important pressor effect during moderate exercise. This suggests blood flow to exercising muscle is a major determinant of cardiovascular responses during dynamic exercise at higher than moderate intensity. Copyright © 2015 the American Physiological Society.

Prediction of Flows about Forebodies at High-Angle-of-Attack Dynamic Conditions

NASA Technical Reports Server (NTRS)

Fremaux, C. M.; vanDam, C. P.; Saephan, S.; DalBello, T.

2003-01-01

A Reynolds-average Navier Stokes method developed for rotorcraft type of flow problems is applied for predicting the forces and moments of forebody models at high-angle-of-attack dynamic conditions and for providing insight into the flow characteristics at these conditions. Wind-tunnel results from rotary testing on generic forebody models conducted by NASA Langley and DERA are used for comparison. This paper focuses on the steady-state flow problem.

USING BIOPLUME IV TO MODEL SUSTAINABILITY OF MNA (ABSTRACT ONLY)

EPA Science Inventory

At most sites where Monitored Natural Attenuation (MNA) has been selected as a remedy for ground water contamination, dilution and dispersion are not the primary mechanisms responsible for attenuation along the flow path in the aquifer. In most aquifers, dilution and dispersion ...

Purely-elastic flow instabilities and elastic turbulence in microfluidic cross-slot devices

PubMed Central

Sousa, P. C.; Pinho, F. T.

2018-01-01

We experimentally investigate the dynamics of viscoelastic fluid flows in cross-slot microgeometries under creeping flow conditions. We focus on the unsteady flow regime observed at high Weissenberg numbers (Wi) with the purpose of understanding the underlying flow signature of elastic turbulence. The effects of the device aspect ratio and fluid rheology on the unsteady flow state are investigated. Visualization of the flow patterns and time-resolved micro-particle image velocimetry were carried out to study the fluid flow behavior for a wide range of Weissenberg numbers. A periodic flow behavior is observed at low Weissenberg numbers followed by a more complex dynamics as Wi increases, eventually leading to the onset of elastic turbulence for very high Weissenberg numbers. PMID:29376533

Flow injection chemiluminescent determination of tetracycline using a tris(2,2'-bipyridine)ruthenium(II)-cerium(IV) sulphate system.

PubMed

Guo, Liangqia; Xie, Zenghong; Lin, Xucong; Liu, Xiaohua; Zhang, Weilin; Chen, Guonan

2004-01-01

A flow-injection chemiluminescence method for the determination of tetracycline was developed. The method is based on an enhancement by tetracycline of the chemiluminescence light emission of tris(2,2'-bipyridine)ruthenium(II). In sulphuric acid medium, the chemiluminescence is generated by the continuous oxidation of tris(2,2'-bipyridine)ruthenium(II) by cerium (IV) sulphate. The light-emission intensity is greatly enhanced in the presence of tetracycline. Under the optimum conditions, the calibration curve is linear over the range 3.75 x 10(-8) g/mL-1.5 x 10(-5) g/mL for tetracycline with the linear equation: deltaINT = 205.898 x C - 20.442 (R2 = 0.9974). The detection limit is 3.27 x 10(-8) g/mL. The proposed method was also successfully used to determine tetracycline in pharmaceutical formulation (mean recovery of tetracycline, 100.7%). Copyright 2004 John Wiley & Sons, Ltd.

A flexible and transparent graphene/ZnO nanorod hybrid structure fabricated by exfoliating a graphite substrate.

PubMed

Nam, Gwang-Hee; Baek, Seong-Ho; Cho, Chang-Hee; Park, Il-Kyu

2014-10-21

We demonstrate the fabrication of a graphene/ZnO nanorod (NR) hybrid structure by mechanical exfoliation of ZnO NRs grown on a graphite substrate. We confirmed the existence of graphene sheets on the hybrid structure by analyzing the Raman spectra and current-voltage (I-V) characteristics. The Raman spectra of the exfoliated graphene/ZnO NR hybrid structure show G and 2D band peaks that are shifted to lower wavenumbers, indicating that the exfoliated graphene layer exists under a significant amount of strain. The I-V characteristics of the graphene/ZnO NR hybrid structure show current flow through the graphene layer, while no current flow is observed on the ZnO NR/polydimethylsiloxane (PDMS) composite without graphene, thereby indicating that the few-layer graphene was successfully transferred onto the hybrid structure. A piezoelectric nanogenerator is demonstrated by using the fabricated graphene/ZnO NR hybrid structure. The nanogenerator exhibits stable output voltage up to 3.04 V with alternating current output characteristics.

The dynamics of a harvested predator-prey system with Holling type IV functional response.

PubMed

Liu, Xinxin; Huang, Qingdao

2018-05-31

The paper aims to investigate the dynamical behavior of a predator-prey system with Holling type IV functional response in which both the species are subject to capturing. We mainly consider how the harvesting affects equilibria, stability, limit cycles and bifurcations in this system. We adopt the method of qualitative and quantitative analysis, which is based on the dynamical theory, bifurcation theory and numerical simulation. The boundedness of solutions, the existence and stability of equilibrium points of the system are further studied. Based on the Sotomayor's theorem, the existence of transcritical bifurcation and saddle-node bifurcation are derived. We use the normal form theorem to analyze the Hopf bifurcation. Simulation results show that the first Lyapunov coefficient is negative and a stable limit cycle may bifurcate. Numerical simulations are performed to make analytical studies more complete. This work illustrates that using the harvesting effort as control parameter can change the behaviors of the system, which may be useful for the biological management. Copyright © 2018 Elsevier B.V. All rights reserved.

Documentation of a finite-element two-layer model for simulation of ground-water flow

USGS Publications Warehouse

Mallory, Michael J.

1979-01-01

This report documents a finite-element model for simulation of ground-water flow in a two-aquifer system where the two aquifers are coupled by a leakage term that represents flow through a confining layer separating the two aquifers. The model was developed by Timothy J. Durbin (U.S. Geological Survey) for use in ground-water investigations in southern California. The documentation assumes that the reader is familiar with the physics of ground-water flow, numerical methods of solving partial-differential equations, and the FORTRAN IV computer language. It was prepared as part of the investigations made by the U.S. Geological Survey in cooperation with the San Bernardino Valley Municipal Water District. (Kosco-USGS)

Fluid-Dynamic Optimal Design of Helical Vascular Graft for Stenotic Disturbed Flow

PubMed Central

Ha, Hojin; Hwang, Dongha; Choi, Woo-Rak; Baek, Jehyun; Lee, Sang Joon

2014-01-01

Although a helical configuration of a prosthetic vascular graft appears to be clinically beneficial in suppressing thrombosis and intimal hyperplasia, an optimization of a helical design has yet to be achieved because of the lack of a detailed understanding on hemodynamic features in helical grafts and their fluid dynamic influences. In the present study, the swirling flow in a helical graft was hypothesized to have beneficial influences on a disturbed flow structure such as stenotic flow. The characteristics of swirling flows generated by helical tubes with various helical pitches and curvatures were investigated to prove the hypothesis. The fluid dynamic influences of these helical tubes on stenotic flow were quantitatively analysed by using a particle image velocimetry technique. Results showed that the swirling intensity and helicity of the swirling flow have a linear relation with a modified Germano number (Gn*) of the helical pipe. In addition, the swirling flow generated a beneficial flow structure at the stenosis by reducing the size of the recirculation flow under steady and pulsatile flow conditions. Therefore, the beneficial effects of a helical graft on the flow field can be estimated by using the magnitude of Gn*. Finally, an optimized helical design with a maximum Gn* was suggested for the future design of a vascular graft. PMID:25360705

Force Evaluation in the Lattice Boltzmann Method Involving Curved Geometry

NASA Technical Reports Server (NTRS)

Mei, Renwei; Yu, Dazhi; Shyy, Wei; Luo, Li-Shi; Bushnell, Dennis M. (Technical Monitor)

2002-01-01

The present work investigates two approaches for force evaluation in the lattice Boltzmann equation: the momentum- exchange method and the stress-integration method on the surface of a body. The boundary condition for the particle distribution functions on curved geometries is handled with second order accuracy based on our recent works. The stress-integration method is computationally laborious for two-dimensional flows and in general difficult to implement for three-dimensional flows, while the momentum-exchange method is reliable, accurate, and easy to implement for both two-dimensional and three-dimensional flows. Several test cases are selected to evaluate the present methods, including: (i) two-dimensional pressure-driven channel flow; (ii) two-dimensional uniform flow past a column of cylinders; (iii) two-dimensional flow past a cylinder asymmetrically placed in a channel (with vortex shedding); (iv) three-dimensional pressure-driven flow in a circular pipe; and (v) three-dimensional flow past a sphere. The drag evaluated by using the momentum-exchange method agrees well with the exact or other published results.

Stopping dynamics of a steady uniform granular flow over a rough incline

NASA Astrophysics Data System (ADS)

Deboeuf, Stéphanie; Saingier, Guillaume; Thiruvalluvar, Nitharshini; Lagrée, Pierre-Yves; Popinet, Stéphane; Staron, Lydie

2017-06-01

Granular material flowing on complex topographies are ubiquitous in industrial and geophysical situations. Even model granular flows are difficult to understand and predict. Recently, the frictional rheology μ(I) -describing the ratio of the shear stress to the normal stress as a function of the inertial number I, that compares inertial and confinement effects- allows unifying different configurations of granular flows. However it does not succeed in describing some phenomenologies, such as creep flow, deposit height, … Is it attributable to the rheology, to non-local effects, ...? Here, we consider a thin layer of grains flowing steadily and uniformly on a rough incline, when the input mass flow rate is suddenly stopped. We focus on the arrest dynamics by using both experimental and numerical approaches. We measure the height and surface velocities of the granular layer during the long-time stopping dynamics and we compare our experimental results with computations of depthaveraged equations for a fluid of rheology μ(I).

Vesicle dynamics in a confined Poiseuille flow: from steady state to chaos.

PubMed

Aouane, Othmane; Thiébaud, Marine; Benyoussef, Abdelilah; Wagner, Christian; Misbah, Chaouqi

2014-09-01

Red blood cells (RBCs) are the major component of blood, and the flow of blood is dictated by that of RBCs. We employ vesicles, which consist of closed bilayer membranes enclosing a fluid, as a model system to study the behavior of RBCs under a confined Poiseuille flow. We extensively explore two main parameters: (i) the degree of confinement of vesicles within the channel and (ii) the flow strength. Rich and complex dynamics for vesicles are revealed, ranging from steady-state shapes (in the form of parachute and slipper shapes) to chaotic dynamics of shape. Chaos occurs through a cascade of multiple periodic oscillations of the vesicle shape. We summarize our results in a phase diagram in the parameter plane (degree of confinement and flow strength). This finding highlights the level of complexity of a flowing vesicle in the small Reynolds number where the flow is laminar in the absence of vesicles and can be rendered turbulent due to elasticity of vesicles.

Chaos in a dynamic model of traffic flows in an origin-destination network.

PubMed

Zhang, Xiaoyan; Jarrett, David F.

1998-06-01

In this paper we investigate the dynamic behavior of road traffic flows in an area represented by an origin-destination (O-D) network. Probably the most widely used model for estimating the distribution of O-D flows is the gravity model, [J. de D. Ortuzar and L. G. Willumsen, Modelling Transport (Wiley, New York, 1990)] which originated from an analogy with Newton's gravitational law. The conventional gravity model, however, is static. The investigation in this paper is based on a dynamic version of the gravity model proposed by Dendrinos and Sonis by modifying the conventional gravity model [D. S. Dendrinos and M. Sonis, Chaos and Social-Spatial Dynamics (Springer-Verlag, Berlin, 1990)]. The dynamic model describes the variations of O-D flows over discrete-time periods, such as each day, each week, and so on. It is shown that when the dimension of the system is one or two, the O-D flow pattern either approaches an equilibrium or oscillates. When the dimension is higher, the behavior found in the model includes equilibria, oscillations, periodic doubling, and chaos. Chaotic attractors are characterized by (positive) Liapunov exponents and fractal dimensions.(c) 1998 American Institute of Physics.

Stage-by-Stage and Parallel Flow Path Compressor Modeling for a Variable Cycle Engine, NASA Advanced Air Vehicles Program - Commercial Supersonic Technology Project - AeroServoElasticity

NASA Technical Reports Server (NTRS)

Kopasakis, George; Connolly, Joseph W.; Cheng, Larry

2015-01-01

This paper covers the development of stage-by-stage and parallel flow path compressor modeling approaches for a Variable Cycle Engine. The stage-by-stage compressor modeling approach is an extension of a technique for lumped volume dynamics and performance characteristic modeling. It was developed to improve the accuracy of axial compressor dynamics over lumped volume dynamics modeling. The stage-by-stage compressor model presented here is formulated into a parallel flow path model that includes both axial and rotational dynamics. This is done to enable the study of compressor and propulsion system dynamic performance under flow distortion conditions. The approaches utilized here are generic and should be applicable for the modeling of any axial flow compressor design accurate time domain simulations. The objective of this work is as follows. Given the parameters describing the conditions of atmospheric disturbances, and utilizing the derived formulations, directly compute the transfer function poles and zeros describing these disturbances for acoustic velocity, temperature, pressure, and density. Time domain simulations of representative atmospheric turbulence can then be developed by utilizing these computed transfer functions together with the disturbance frequencies of interest.

LION4; LION; three-dimensional temperature distribution program. [CDC6600,7600; UNIVAC1108; IBM360,370; FORTRAN IV and ASCENT (CDC6600,7600), FORTRAN IV (UNIVAC1108A,B and IBM360,370)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Binney, E.J.

LION4 is a computer program for calculating one-, two-, or three-dimensional transient and steady-state temperature distributions in reactor and reactor plant components. It is used primarily for thermal-structural analyses. It utilizes finite difference techniques with first-order forward difference integration and is capable of handling a wide variety of bounding conditions. Heat transfer situations accommodated include forced and free convection in both reduced and fully-automated temperature dependent forms, coolant flow effects, a limited thermal radiation capability, a stationary or stagnant fluid gap, a dual dependency (temperature difference and temperature level) heat transfer, an alternative heat transfer mode comparison and selection facilitymore » combined with heat flux direction sensor, and any form of time-dependent boundary temperatures. The program, which handles time and space dependent internal heat generation, can also provide temperature dependent material properties with limited non-isotropic properties. User-oriented capabilities available include temperature means with various weightings and a complete heat flow rate surveillance system.CDC6600,7600;UNIVAC1108;IBM360,370; FORTRAN IV and ASCENT (CDC6600,7600), FORTRAN IV (UNIVAC1108A,B and IBM360,370); SCOPE (CDC6600,7600), EXEC8 (UNIVAC1108A,B), OS/360,370 (IBM360,370); The CDC6600 version plotter routine LAPL4 is used to produce the input required by the associated CalComp plotter for graphical output. The IBM360 version requires 350K for execution and one additional input/output unit besides the standard units.« less

Identification of type IV collagen exposure as a molecular imaging target for early detection of thoracic aortic dissection

PubMed Central

Xu, Ke; Xu, Chen; Zhang, Yanzhenzi; Qi, Feiran; Yu, Bingran; Li, Ping; Jia, Lixin; Li, Yulin; Xu, Fu-jian; Du, Jie

2018-01-01

Thoracic aortic dissection (TAD) is an aggressive and life-threatening vascular disease and there is no effective means of early diagnosis of dissection. Type IV collagen (Col-IV) is a major component of the sub-endothelial basement membrane, which is initially exposed followed by endothelial injury as early-stage event of TAD. So, we want to build a noninvasive diagnostic method to detect early dissection by identifying the exposed Col-IV via MRI. Methods: Col-IV-targeted magnetic resonance/ fluorescence dual probe (Col-IV-DOTA-Gd-rhodamine B; CDR) was synthesized by amide reaction and coordination reaction. Flow cytometry analysis was used to evaluate the cell viability of SMC treated with CDR and fluorescence assays were used to assess the Col-IV targeting ability of CDR in vitro. We then examined the sensitivity and specificity of CDR at different stages of TAD via MRI and bioluminescence imaging in vivo. Results: The localization of Col-IV (under the intima) was observed by histology images. CDR bound specifically to Col-IV-expressing vascular smooth muscle cells and BAPN-induced dissected aorta. The CDR signal was co-detected by magnetic resonance imaging (MRI) and bioluminescence imaging as early as 2 weeks after BAPN administration (pre-dissection stage). The ability to detect rupture of dissected aorta was indicated by a strong normalized signal enhancement (NSE) in vivo. Moreover, NSE was negatively correlated with the time of dissection rupture after BAPN administration (r2 = 0.8482). Conclusion: As confirmed by in vivo studies, the CDR can identify the exposed Col-IV in degenerated aorta to monitor the progress of aortic dissection from the early stage to the rupture via MRI. Thus, CDR-enhanced MRI proposes a potential method for dissection screening, and for monitoring disease progression and therapeutic response. PMID:29290819

Navier-Stokes, dynamics and aeroelastic computations for vortical flows, buffet and flutter applications

NASA Technical Reports Server (NTRS)

Kandil, Osama A.

1993-01-01

Research on Navier-Stokes, dynamics, and aeroelastic computations for vortical flows, buffet, and flutter applications was performed. Progress during the period from 1 Oct. 1992 to 30 Sep. 1993 is included. Papers on the following topics are included: vertical tail buffet in vortex breakdown flows; simulation of tail buffet using delta wing-vertical tail configuration; shock-vortex interaction over a 65-degree delta wing in transonic flow; supersonic vortex breakdown over a delta wing in transonic flow; and prediction and control of slender wing rock.

The Dynamics of Flowing Waters.

ERIC Educational Resources Information Center

Mattingly, Rosanna L.

1987-01-01

Describes a series of activities designed to help students understand the dynamics of flowing water. Includes investigations into determining water discharge, calculating variable velocities, utilizing flood formulas, graphing stream profiles, and learning about the water cycle. (TW)

Influence of chemical reactions on the nonlinear dynamics of dissipative flows

NASA Astrophysics Data System (ADS)

Karimov, A. R.; Korshunov, A. M.; Beklemishev, V. V.

2015-08-01

The nonlinear dynamics of resistive flow with a chemical reaction is studied. Proceeding from the Lagrangian description, the influence of a chemical reaction on the development of fluid singularities is considered.

The Dynamics of Rapidly Emplaced Terrestrial Lava Flows and Implications for Planetary Volcanism

NASA Technical Reports Server (NTRS)

Baloga, Stephen; Spudis, Paul D.; Guest, John E.

1995-01-01

The Kaupulehu 1800-1801 lava flow of Hualalai volcano and the 1823 Keaiwa flow from the Great Crack of the Kilauea southwest rift zone had certain unusual and possibly unique properties for terrestrial basaltic lava flows. Both flows apparently had very low viscosities, high effusion rates, and uncommonly rapid rates of advance. Ultramafic xenolith nodules in the 1801 flow form stacks of cobbles with lava rinds of only millimeter thicknesses. The velocity of the lava stream in the 1801 flow was extremely high, at least 10 m/s (more than 40 km/h). Observations and geological evidence suggest similarly high velocities for the 1823 flow. The unusual eruption conditions that produced these lava flows suggest a floodlike mode of emplacement unlike that of most other present-day flows. Although considerable effort has gone into understanding the viscous fluid dynamics and thermal processes that often occur in basaltic flows, the unusual conditions prevalent for the Kaupulehu and Keaiwa flows necessitate different modeling considerations. We propose an elementary flood model for this type of lava emplacement and show that it produces consistent agreement with the overall dimensions of the flow, channel sizes, and other supporting field evidence. The reconstructed dynamics of these rapidly emplaced terrestrial lava flows provide significant insights about the nature of these eruptions and their analogs in planetary volcanism.

Effects of speckle/pixel size ratio on temporal and spatial speckle-contrast analysis of dynamic scattering systems: Implications for measurements of blood-flow dynamics.

PubMed

Ramirez-San-Juan, J C; Mendez-Aguilar, E; Salazar-Hermenegildo, N; Fuentes-Garcia, A; Ramos-Garcia, R; Choi, B

2013-01-01

Laser Speckle Contrast Imaging (LSCI) is an optical technique used to generate blood flow maps with high spatial and temporal resolution. It is well known that in LSCI, the speckle size must exceed the Nyquist criterion to maximize the speckle's pattern contrast. In this work, we study experimentally the effect of speckle-pixel size ratio not only in dynamic speckle contrast, but also on the calculation of the relative flow speed for temporal and spatial analysis. Our data suggest that the temporal LSCI algorithm is more accurate at assessing the relative changes in flow speed than the spatial algorithm.

The flow dynamics behind a flexible finite cylinder as a flexible agitator

NASA Astrophysics Data System (ADS)

Yong, T. H.; Chan, H. B.; Dol, S. S.; Wee, S. K.; Kumar, P.

2017-06-01

This paper investigates the flow dynamics behind a flexible finite cylinder in a single-phase flow using a water tunnel. The cylinder was individually submerged in water at ReD = 4000, 6000 and 8000. The cylinder investigated has a AR = 10 and 16 and is made of EVA in order to achieve the lower stiffness for flexibility. A same AR of its aluminium rigid cylinder was investigated to serve as a benchmark to the flow dynamics behind a flexible cylinder. The results the downwash that hinders the transportation of vortices to the downstream was diminished. As a direct consequence of this phenomenon, the turbulence production has seen significant improvement for flexible finite cylinder.

In Vitro Test for Potential Inhibitors of Plasmepsin II and IV as Anti-malarial Agents

NASA Astrophysics Data System (ADS)

Kang, Hee-Kyoung; Hwang, Soon-Wook; Kim, Do-Won; Breton, Vincent; Kim, Doman

Plasmepsins (PMs) are involved in the degradation of host cell hemoglobin during malaria infection. PM II and IV initiate the degradative process, and have been suggested as attractive targets for treatment of malaria. Previously, 30 compounds were identified by post-processing the results of a large docking screen of commercially available compounds using an automated procedure based on molecular dynamics refinement and binding free-energy estimation using MM-PBSA and MM-GBSA (Degliesposti et al., 2009). Presently, these were experimentally validated using an inhibition assay based on fluorescence resonance energy transfer (FRET) and hemoglobin substrate degradation. Remarkably, 26 of the 30 tested compounds were active as PM II inhibitors, with FRET IC50 values ranging from 4.3 nM to 1.8 μM. Also, IC50 value for PM IV inhibition ranged from 9.34 nM to 83 μM and the best inhibitor among the 30 compounds was compound 7. Hemoglobin degradation by recombinant PM II and IV was completely inhibited by 100 μM of compound 7. The newly identified compounds, and one in particular (compound 7), can inhibit PM II and IV activity and hemoglobin degradation in vitro. These experiments suggest an overall approach in the design of powerful and selective PM II and IV inhibitors.

AN ERUPTIVE HOT-CHANNEL STRUCTURE OBSERVED AT METRIC WAVELENGTH AS A MOVING TYPE-IV SOLAR RADIO BURST

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vasanth, V.; Chen, Yao; Feng, Shiwei

2016-10-10

Hot-channel (HC) structure, observed in the high-temperature passbands of the Atmospheric Imaging Assembly/ Solar Dynamic Observatory , is regarded as one candidate of coronal flux rope that is an essential element of solar eruptions. Here, we present the first radio imaging study of an HC structure in the metric wavelength. The associated radio emission manifests as a moving type-IV (t-IVm) burst. We show that the radio sources co-move outward with the HC, indicating that the t-IV emitting energetic electrons are efficiently trapped within the structure. The t-IV sources at different frequencies present no considerable spatial dispersion during the early stagemore » of the event, while the sources spread gradually along the eruptive HC structure at later stage with significant spatial dispersion. The t-IV bursts are characterized by a relatively high brightness temperature (∼10{sup 7}–10{sup 9} K), a moderate polarization, and a spectral shape that evolves considerably with time. This study demonstrates the possibility of imaging the eruptive HC structure at the metric wavelength and provides strong constraints on the t-IV emission mechanism, which, if understood, can be used to diagnose the essential parameters of the eruptive structure.« less

Solar neutrino measurements in Super-Kamiokande-IV

NASA Astrophysics Data System (ADS)

Abe, K.; Haga, Y.; Hayato, Y.; Ikeda, M.; Iyogi, K.; Kameda, J.; Kishimoto, Y.; Marti, Ll.; Miura, M.; Moriyama, S.; Nakahata, M.; Nakajima, T.; Nakayama, S.; Orii, A.; Sekiya, H.; Shiozawa, M.; Sonoda, Y.; Takeda, A.; Tanaka, H.; Takenaga, Y.; Tasaka, S.; Tomura, T.; Ueno, K.; Yokozawa, T.; Akutsu, R.; Irvine, T.; Kaji, H.; Kajita, T.; Kametani, I.; Kaneyuki, K.; Lee, K. P.; Nishimura, Y.; McLachlan, T.; Okumura, K.; Richard, E.; Labarga, L.; Fernandez, P.; Blaszczyk, F. d. M.; Gustafson, J.; Kachulis, C.; Kearns, E.; Raaf, J. L.; Stone, J. L.; Sulak, L. R.; Berkman, S.; Tobayama, S.; Goldhaber, M.; Bays, K.; Carminati, G.; Griskevich, N. J.; Kropp, W. R.; Mine, S.; Renshaw, A.; Smy, M. B.; Sobel, H. W.; Takhistov, V.; Weatherly, P.; Ganezer, K. S.; Hartfiel, B. L.; Hill, J.; Keig, W. E.; Hong, N.; Kim, J. Y.; Lim, I. T.; Park, R. G.; Akiri, T.; Albert, J. B.; Himmel, A.; Li, Z.; O'Sullivan, E.; Scholberg, K.; Walter, C. W.; Wongjirad, T.; Ishizuka, T.; Nakamura, T.; Jang, J. S.; Choi, K.; Learned, J. G.; Matsuno, S.; Smith, S. N.; Friend, M.; Hasegawa, T.; Ishida, T.; Ishii, T.; Kobayashi, T.; Nakadaira, T.; Nakamura, K.; Nishikawa, K.; Oyama, Y.; Sakashita, K.; Sekiguchi, T.; Tsukamoto, T.; Nakano, Y.; Suzuki, A. T.; Takeuchi, Y.; Yano, T.; Cao, S. V.; Hayashino, T.; Hiraki, T.; Hirota, S.; Huang, K.; Ieki, K.; Jiang, M.; Kikawa, T.; Minamino, A.; Murakami, A.; Nakaya, T.; Patel, N. D.; Suzuki, K.; Takahashi, S.; Wendell, R. A.; Fukuda, Y.; Itow, Y.; Mitsuka, G.; Muto, F.; Suzuki, T.; Mijakowski, P.; Frankiewicz, K.; Hignight, J.; Imber, J.; Jung, C. K.; Li, X.; Palomino, J. L.; Santucci, G.; Taylor, I.; Vilela, C.; Wilking, M. J.; Yanagisawa, C.; Fukuda, D.; Ishino, H.; Kayano, T.; Kibayashi, A.; Koshio, Y.; Mori, T.; Sakuda, M.; Takeuchi, J.; Yamaguchi, R.; Kuno, Y.; Tacik, R.; Kim, S. B.; Okazawa, H.; Choi, Y.; Ito, K.; Nishijima, K.; Koshiba, M.; Totsuka, Y.; Suda, Y.; Yokoyama, M.; Bronner, C.; Calland, R. G.; Hartz, M.; Martens, K.; Obayashi, Y.; Suzuki, Y.; Vagins, M. R.; Nantais, C. M.; Martin, J. F.; de Perio, P.; Tanaka, H. A.; Konaka, A.; Chen, S.; Sui, H.; Wan, L.; Yang, Z.; Zhang, H.; Zhang, Y.; Connolly, K.; Dziomba, M.; Wilkes, R. J.; Super-Kamiokande Collaboration

2016-09-01

Upgraded electronics, improved water system dynamics, better calibration and analysis techniques allowed Super-Kamiokande-IV to clearly observe very low-energy 8B solar neutrino interactions, with recoil electron kinetic energies as low as ˜3.5 MeV . Super-Kamiokande-IV data-taking began in September of 2008; this paper includes data until February 2014, a total livetime of 1664 days. The measured solar neutrino flux is (2.308 ±0.020 (stat)-0.040 +0.039(syst ))×1 06/(cm2 sec ) assuming no oscillations. The observed recoil electron energy spectrum is consistent with no distortions due to neutrino oscillations. An extended maximum likelihood fit to the amplitude of the expected solar zenith angle variation of the neutrino-electron elastic scattering rate in SK-IV results in a day/night asymmetry of (-3.6 ±1.6 (stat )±0.6 (syst ))% . The SK-IV solar neutrino data determine the solar mixing angle as sin2θ12=0.327-0.031+0.026 , all SK solar data (SK-I, SK-II, SK III and SK-IV) measures this angle to be sin2θ12=0.334-0.023+0.027 , the determined mass-squared splitting is Δ m212=4.8-0.8+1.5×10-5 eV2 .

A FORTRAN IV Computer Program for the Time Domain Analysis of the Two- Dimensional Dynamic Motions of General Buoy-Cable-Body Systems

DTIC Science & Technology

1977-06-01

SPHEROIDAL BUOYS As mentioned previously, for the limiting case of zero ; educed frequency where tile free surface behaves as a rigid plane, the...4P ) -4 -4 ft O D - % Cdd :# P) fy ou Cd 1d Cd’. . 6 - C3 ’o .. eg S w Cd *g.4C~dI~**II~.a Ký 0 4 : 10 In H-C IV ..4 _ C) bu 0 40 la W C2C W cc lp lqa

Structural Changes in Lipid Vesicles Generated by the Shock Blast Waves: Coarse-Grained Molecular Dynamics Simulation

DTIC Science & Technology

2013-11-01

duration, or shock-pulse shape. Used in this computational study is a coarse-grained model of the lipid vesicle as a simplified model of a cell...Figures iv List of Tables iv 1. Introduction 1 2. Model and Methods 3 3. Results and Discussion 6 3.1 Simulation of the Blast Waves with Low Peak...realistic detail but to focus on a simple model of the major constituent of a cell membrane, the phospholipid bilayer. In this work, we studied the

Numerical simulations of the charged-particle flow dynamics for sources with a curved emission surface

NASA Astrophysics Data System (ADS)

Altsybeyev, V. V.

2016-12-01

The implementation of numerical methods for studying the dynamics of particle flows produced by pulsed sources is discussed. A particle tracking method with so-called gun iteration for simulations of beam dynamics is used. For the space charge limited emission problem, we suggest a Gauss law emission model for precise current-density calculation in the case of a curvilinear emitter. The results of numerical simulations of particle-flow formation for cylindrical bipolar diode and for diode with elliptical emitter are presented.

Phase diagram of single vesicle dynamical states in shear flow.

PubMed

Deschamps, J; Kantsler, V; Steinberg, V

2009-03-20

We report the first experimental phase diagram of vesicle dynamical states in a shear flow presented in a space of two dimensionless parameters suggested recently by V. Lebedev et al. To reduce errors in the control parameters, 3D geometrical reconstruction and determination of the viscosity contrast of a vesicle in situ in a plane Couette flow device prior to the experiment are developed. Our results are in accord with the theory predicting three distinctly separating regions of vesicle dynamical states in the plane of just two self-similar parameters.

Whole-body PET/CT evaluation of tumor perfusion using generator-based 62Cu-ethylglyoxal bis(thiosemicarbazonato)copper(II): validation by direct comparison to 15O-water in metastatic renal cell carcinoma.

PubMed

Fletcher, James W; Logan, Theodore F; Eitel, Jacob A; Mathias, Carla J; Ng, Yen; Lacy, Jeffrey L; Hutchins, Gary D; Green, Mark A

2015-01-01

This study was undertaken to demonstrate the feasibility of whole-body (62)Cu-ethylglyoxal bis(thiosemicarbazonato)copper(II) ((62)Cu-ETS) PET/CT tumor perfusion imaging in patients with metastatic renal carcinoma and to validate (62)Cu-ETS as a quantitative marker of tumor perfusion by direct comparison with (15)O-water perfusion imaging. PET/CT imaging of 10 subjects with stage IV renal cell cancer was performed after intravenous administration of (15)O-water (10-min dynamic list-mode study) with the heart and at least 1 tumor in the PET field of view, followed 10 min later by intravenous (62)Cu-ETS (6-min list-mode study). Whole-body (62)Cu imaging was then performed from 6 to 20 min at 2-3 min/bed position. Blood flow (K1) was quantified with both agents for normal and malignant tissues in the 21.7-cm dynamic field of view. The required arterial input functions were derived from the left atrium and, in the case of (62)Cu-ETS, corrected for partial decomposition of the agent by blood with data from an in vitro analysis using a sample of each patient's blood. This imaging protocol was repeated at an interval of 3-4 wk after initiation of a standard clinical treatment course of the antiangiogenic agent sunitinib. All subjects received the scheduled (62)Cu-ETS doses for the dynamic and subsequent whole-body PET/CT scans, but technical issues resulted in no baseline (15)O-water data for 2 subjects. Direct comparisons of the perfusion estimates for normal tissues and tumor metastases were made in 18 paired baseline and treatment studies (10 subjects; 8 baseline studies, 10 repeated studies during treatment). There was an excellent correlation between the blood flow estimates made with (62)Cu-ETS and (15)O-water for normal tissues (muscle, thyroid, myocardium) and malignant lesions (pulmonary nodules, bone lesions); the regression line was y = 0.85x + 0.15, R(2) = 0.83, for the 88 regions analyzed. (62)Cu-ETS provided high-quality whole-body PET/CT images, and (62)Cu-ETS measures of blood flow were highly and linearly correlated with (15)O-water-derived K1 values (mL(-1) ⋅ min(-1) ⋅ g). This tracer is suitable for use as a PET tracer of tumor perfusion in patients with metastatic renal cell carcinoma. © 2015 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

The Dynamics of Agglomerated Ferrofluid in Steady and Pulsatile Flows

NASA Astrophysics Data System (ADS)

Williams, Alicia; Stewart, Kelley; Vlachos, Pavlos

2007-11-01

Magnetic Drug Targeting (MDT) is a promising technique to deliver medication via functionalized magnetic particles to target sites in the treatment of diseases. In this work, the physics of steady and pulsatile flows laden with superparamagnetic nanoparticles in a square channel under the influence of a magnetic field induced by a 0.6 Tesla permanent magnet is studied. Herein, the dynamics of ferrofluid shedding from an initially accumulated mass in water are examined through shadowgraph imaging using two orthogonal cameras. Fundamental differences in the ferrofluid behavior occur between the steady and pulsatile flow cases, as expected. For steady flows, vortex ring shedding is visualized from the mass, and periodic shedding occurs only for moderate mass sizes where the shear forces in the flow interact with the magnetic forces. At Reynolds numbers below 500 with pulsatile flow, suction and roll up of the ferrofluid is seen during the low and moderate periods of flow, followed by the ejection of ferrofluid during high flow. These shadowgraphs illustrate the beauty and richness of ferrofluid dynamics, an understanding of which is instrumental to furthering MDT as an effective drug delivery device.

Dynamic Pressure Probes Developed for Supersonic Flow-Field Measurements

NASA Technical Reports Server (NTRS)

Porro, A. Robert

2001-01-01

A series of dynamic flow-field pressure probes were developed for use in large-scale supersonic wind tunnels at the NASA Glenn Research Center. These flow-field probes include pitot and static pressure probes that can capture fast-acting flow-field pressure transients occurring on a millisecond timescale. The pitot and static probes can be used to determine local Mach number time histories during a transient event. The flow-field pressure probe contains four major components: 1) Static pressure aerodynamic tip; 2) Pressure-sensing cartridge assembly; 3) Pitot pressure aerodynamic tip; 4) Mounting stem. This modular design allows for a variety of probe tips to be used for a specific application. Here, the focus is on flow-field pressure measurements in supersonic flows, so we developed a cone-cylinder static pressure tip and a pitot pressure tip. Alternatively, probe tips optimized for subsonic and transonic flows could be used with this design. The pressure-sensing cartridge assembly allows the simultaneous measurement of steady-state and transient pressure which allows continuous calibration of the dynamic pressure transducer.

Further development of an electroosmotic medium pump system for preparative disk gel electrophoresis.

PubMed

Hayakawa, Mitsuo; Hosogi, Yumiko; Takiguchi, Hisashi; Shiroza, Teruaki; Shibata, Yasuko; Hiratsuka, Koichi; Kiyama-Kishikawa, Michiko; Hamajima, Susumu; Abiko, Yoshimitsu

2003-02-01

A simple and practical 6.8-cm-diameter (36.30-cm(2) cross-sectional-area) preparative disk gel electrophoresis device, based on the design of M. Hayakawa et al. (Anal. Biochem. 288 (2001) 168), in which the elution buffer is driven by an electroosmotic buffer flow through the membrane into the elution chamber from the anode chamber was constructed. We have found that the dialysis membranes employed provide suitable flow rates for the elution buffer, similar to those of an earlier 3.6-cm-diameter device, resulting in the prevention of excess eluate dilution. The efficiency of this device was demonstrated by the fractionation of a bovine serum albumin (BSA) Cohn V fraction into monomer, dimer, and oligomer components using nondenaturing polyacrylamide gel electrophoresis (native-PAGE). The maximum protein concentration of the eluate achieved was 133 mg/ml of BSA monomer, which required a dilution of the eluate for subsequent analytical PAGE performance. As a practical example, the two-dimensional fractionation of soluble dipeptidyl peptidase IV (sDPP IV) from 50 ml fetal bovine serum (3.20 g protein) per gel is presented. The sDPP IV enzyme protein was recovered in a relatively short time, utilizing a 6.5% T native-PAGE and subsequential sodium dodecyl sulfate-PAGE system. This device enhances the possibility of continuous electrophoretic fractionation of complex protein mixtures on a preparative scale. Copyright 2003 Elsevier Science (USA)

Internet traffic load balancing using dynamic hashing with flow volume

NASA Astrophysics Data System (ADS)

Jo, Ju-Yeon; Kim, Yoohwan; Chao, H. Jonathan; Merat, Francis L.

2002-07-01

Sending IP packets over multiple parallel links is in extensive use in today's Internet and its use is growing due to its scalability, reliability and cost-effectiveness. To maximize the efficiency of parallel links, load balancing is necessary among the links, but it may cause the problem of packet reordering. Since packet reordering impairs TCP performance, it is important to reduce the amount of reordering. Hashing offers a simple solution to keep the packet order by sending a flow over a unique link, but static hashing does not guarantee an even distribution of the traffic amount among the links, which could lead to packet loss under heavy load. Dynamic hashing offers some degree of load balancing but suffers from load fluctuations and excessive packet reordering. To overcome these shortcomings, we have enhanced the dynamic hashing algorithm to utilize the flow volume information in order to reassign only the appropriate flows. This new method, called dynamic hashing with flow volume (DHFV), eliminates unnecessary flow reassignments of small flows and achieves load balancing very quickly without load fluctuation by accurately predicting the amount of transferred load between the links. In this paper we provide the general framework of DHFV and address the challenges in implementing DHFV. We then introduce two algorithms of DHFV with different flow selection strategies and show their performances through simulation.

Urinary type IV collagen is related to left ventricular diastolic function and brain natriuretic peptide in hypertensive patients with prediabetes.

PubMed

Iida, Masato; Yamamoto, Mitsuru; Ishiguro, Yuko S; Yamazaki, Masatoshi; Ueda, Norihiro; Honjo, Haruo; Kamiya, Kaichirou

2014-01-01

Urinary type IV collagen is an early biomarker of diabetic nephropathy. Concomitant prediabetes (the early stage of diabetes) was associated with left ventricular (LV) diastolic dysfunction and increased brain natriuretic peptide (BNP) in hypertensive patients. We hypothesized that urinary type IV collagen may be related to these cardiac dysfunctions. We studied hypertensive patients with early prediabetes (HbA1c <5.7% and fasting glucose >110, n=18), those with prediabetes (HbA1c 5.7-6.4, n=98), and those with diabetes (HbA1c>6.5 or on diabetes medications, n=92). The participants underwent echocardiography to assess left atrial volume/body surface area (BSA) and the ratio of early mitral flow velocity to mitral annular velocity (E/e'). Left ventricular diastolic dysfunction (LVDD) was defined if patients had E/e'≥15, or E/e'=9-14 accompanied by left atrial volume/BSA≥32ml/mm(2). Urinary samples were collected for type IV collagen and albumin, and blood samples were taken for BNP and HbA1c. Urinary type IV collagen and albumin increased in parallel with the deterioration of glycemic status. In hypertensive patients with prediabetes, subjects with LVDD had higher levels of BNP and urinary type IV collagen than those without LVDD. In contrast, in hypertensive patients with diabetes, subjects with LVDD had higher urinary albumin and BNP than those without LVDD. Urinary type IV collagen correlated positively with BNP in hypertensive patients with prediabetes, whereas it correlated with HbA1c in those with diabetes. In hypertensive patients with prediabetes, urinary type IV collagen was associated with LV diastolic dysfunction and BNP. Copyright © 2014 Elsevier Inc. All rights reserved.

MR-perfusion (MRP) and diffusion-weighted imaging (DWI) in prostate cancer: quantitative and model-based gadobenate dimeglumine MRP parameters in detection of prostate cancer.

PubMed

Scherr, M K; Seitz, M; Müller-Lisse, U G; Ingrisch, M; Reiser, M F; Müller-Lisse, U L

2010-12-01

Various MR methods, including MR-spectroscopy (MRS), dynamic, contrast-enhanced MRI (DCE-MRI), and diffusion-weighted imaging (DWI) have been applied to improve test quality of standard MRI of the prostate. To determine if quantitative, model-based MR-perfusion (MRP) with gadobenate dimeglumine (Gd-BOPTA) discriminates between prostate cancer, benign tissue, and transitional zone (TZ) tissue. 27 patients (age, 65±4 years; PSA 11.0±6.1 ng/ml) with clinical suspicion of prostate cancer underwent standard MRI, 3D MR-spectroscopy (MRS), and MRP with Gd-BOPTA. Based on results of combined MRI/MRS and subsequent guided prostate biopsy alone (17/27), biopsy and radical prostatectomy (9/27), or sufficient negative follow-up (7/27), maps of model-free, deconvolution-based mean transit time (dMTT) were generated for 29 benign regions (bROIs), 14 cancer regions (cROIs), and 18 regions of transitional zone (tzROIs). Applying a 2-compartment exchange model, quantitative perfusion analysis was performed including as parameters: plasma flow (PF), plasma volume (PV), plasma mean transit time (PMTT), extraction flow (EFL), extraction fraction (EFR), interstitial volume (IV) and interstitial mean transit time (IMTT). Two-sided T-tests (significance level p<0.05) discriminated bROIs vs. cROIs and cROIs vs. tzROIs, respectively. PMTT discriminated best between bROIs (11.8±3.0 s) and cROIs (24.3±9.6 s) (p<0.0001), while PF, PV, PS, EFR, IV, IMTT also differed significantly (p 0.00002-0.0136). Discrimination between cROIs and tzROIs was insignificant for all parameters except PV (14.3±2.5 ml vs. 17.6±2.6 ml, p<0.05). Besides MRI, MRS and DWI quantitative, 2-compartment MRP with Gd-BOPTA discriminates between prostate cancer and benign tissue with several parameters. However, distinction of prostate cancer and TZ does not appear to be reliable. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

IRBM for the Rio Conchos Basin as a Restoration and Conservation Tool

NASA Astrophysics Data System (ADS)

Barrios, E.; Rodriguez, J. A.; de La Maza, M.

2007-12-01

The Rio Conchos basin is the main water supply for the people of the State of Chihuahua and the middle and lower Rio Bravo in northern Mexico. Flowing for about 850 km from the highlands of the Sierra Tarahumara towards the wide valleys of the Chihuahuan Desert, the river presents recurrent periods of water stress and its basin of 6.7 million of hectares experiences a wide spectrum of problems such us long drought periods, water over allocation and extraction, water pollution, severe soil use changes. Besides, drastic soil moisture reduction is forecasted by effects of climate change. These natural and anthropological harmful situations impose a serious stress for this important and beautiful river and the rest of the basin hydrological resources. The WWF-Gonzalo Rio Arronte Alliance and its partners USAID, The Coca Cola Company and RICOH are implementing since 2004 an Integrated River Basin Management (IRBM) strategy to recover the natural integrity of the Rio Conchos in the form of environmental flow. The strategy includes the five basic working lines: i) development of river basin scientific knowledge, ii) strengthen of local institutional capacities, iii) development of demonstrative projects, iv) strengthen of indigenous communities, v) education and communication. Although the implementation of the IRBM program is expected to show main results until the year 2050, some interesting results have been obtained. The strategy has provided i) new basic knowledge about the basin dynamic events such as soil change use rates, baseline values of biological integrity, water economic values, among others; ii) strong program acceptance by government and main water users (farmers), and the integration of a working group formed by government, academia and NGO's; iii) local acceptance and understanding of benefits about basin management (soil recovery, reforestation, ecological sanitation) through demonstrative projects; iv) social organization; v) few advances in education and communications have been obtained. Some of the negative results of program implementation are lack of positive acceptance by powerful groups and a couple of NGO's currently working in the basin, and low credibility from indigenous governors (leaders of the Tarahumara group).