Device and method for measuring multi-phase fluid flow and density of fluid in a conduit having a gradual bend

DOEpatents

Ortiz, M.G.; Boucher, T.J.

1998-10-27

A system is described for measuring fluid flow in a conduit having a gradual bend or arc, and a straight section. The system includes pressure transducers, one or more disposed in the conduit on the outside of the arc, and one disposed in the conduit in a straight section thereof. The pressure transducers measure the pressure of fluid in the conduit at the locations of the pressure transducers and this information is used by a computational device to calculate fluid flow rate in the conduit. For multi-phase fluid, the density of the fluid is measured by another pair of pressure transducers, one of which is located in the conduit elevationally above the other. The computation device then uses the density measurement along with the fluid pressure measurements, to calculate fluid flow. 1 fig.

3D real-time visualization of blood flow in cerebral aneurysms by light field particle image velocimetry

NASA Astrophysics Data System (ADS)

Carlsohn, Matthias F.; Kemmling, André; Petersen, Arne; Wietzke, Lennart

2016-04-01

Cerebral aneurysms require endovascular treatment to eliminate potentially lethal hemorrhagic rupture by hemostasis of blood flow within the aneurysm. Devices (e.g. coils and flow diverters) promote homeostasis, however, measurement of blood flow within an aneurysm or cerebral vessel before and after device placement on a microscopic level has not been possible so far. This would allow better individualized treatment planning and improve manufacture design of devices. For experimental analysis, direct measurement of real-time microscopic cerebrovascular flow in micro-structures may be an alternative to computed flow simulations. An application of microscopic aneurysm flow measurement on a regular basis to empirically assess a high number of different anatomic shapes and the corresponding effect of different devices would require a fast and reliable method at low cost with high throughout assessment. Transparent three dimensional 3D models of brain vessels and aneurysms may be used for microscopic flow measurements by particle image velocimetry (PIV), however, up to now the size of structures has set the limits for conventional 3D-imaging camera set-ups. On line flow assessment requires additional computational power to cope with the processing large amounts of data generated by sequences of multi-view stereo images, e.g. generated by a light field camera capturing the 3D information by plenoptic imaging of complex flow processes. Recently, a fast and low cost workflow for producing patient specific three dimensional models of cerebral arteries has been established by stereo-lithographic (SLA) 3D printing. These 3D arterial models are transparent an exhibit a replication precision within a submillimeter range required for accurate flow measurements under physiological conditions. We therefore test the feasibility of microscopic flow measurements by PIV analysis using a plenoptic camera system capturing light field image sequences. Averaging across a sequence of single double or triple shots of flashed images enables reconstruction of the real-time corpuscular flow through the vessel system before and after device placement. This approach could enable 3D-insight of microscopic flow within blood vessels and aneurysms at submillimeter resolution. We present an approach that allows real-time assessment of 3D particle flow by high-speed light field image analysis including a solution that addresses high computational load by image processing. The imaging set-up accomplishes fast and reliable PIV analysis in transparent 3D models of brain aneurysms at low cost. High throughput microscopic flow assessment of different shapes of brain aneurysms may therefore be possibly required for patient specific device designs.

Measurements of Turbulent Flow Field in Separate Flow Nozzles with Enhanced Mixing Devices - Test Report

NASA Technical Reports Server (NTRS)

Bridges, James

2002-01-01

As part of the Advanced Subsonic Technology Program, a series of experiments was conducted at NASA Glenn Research Center on the effect of mixing enhancement devices on the aeroacoustic performance of separate flow nozzles. Initial acoustic evaluations of the devices showed that they reduced jet noise significantly, while creating very little thrust loss. The explanation for the improvement required that turbulence measurements, namely single point mean and RMS statistics and two-point spatial correlations, be made to determine the change in the turbulence caused by the mixing enhancement devices that lead to the noise reduction. These measurements were made in the summer of 2000 in a test program called Separate Nozzle Flow Test 2000 (SFNT2K) supported by the Aeropropulsion Research Program at NASA Glenn Research Center. Given the hot high-speed flows representative of a contemporary bypass ratio 5 turbofan engine, unsteady flow field measurements required the use of an optical measurement method. To achieve the spatial correlations, the Particle Image Velocimetry technique was employed, acquiring high-density velocity maps of the flows from which the required statistics could be derived. This was the first successful use of this technique for such flows, and shows the utility of this technique for future experimental programs. The extensive statistics obtained were likewise unique and give great insight into the turbulence which produces noise and how the turbulence can be modified to reduce jet noise.

Comparison of Two Devices for Intraoperative Portal Venous Flow Measurement in Living-Donor Liver Transplantation: Transit Time Ultrasound and Conventional Doppler Ultrasound.

PubMed

Wang, H-K; Chen, C-Y; Lin, N-C; Liu, C-S; Loong, C-C; Lin, Y-H; Lai, Y-C; Chiou, H-J

2018-05-01

Intraoperative portal venous flow measurement provides surgeons with instant guidance for portal flow modulation during living-donor liver transplantation (LDLT). In this study, we compared the agreement of portal flow measurement obtained by 2 devices: transit time ultrasound (TTU) and conventional Doppler ultrasound (CDU). Fifty-four recipients of LDLT underwent intraoperative measurement of portal flow after completion of vascular anastomosis of the implanted partial liver graft. Both TTU and CDU were used concurrently. Agreement of TTU and CDU was assessed by intraclass correlation coefficient using a model of 2-way random effects, absolute agreement, and single measurement. A Bland-Altman plot was applied to assess the variability between the 2 devices. The mean, median, and range of portal venous flow was 1456, 1418, and 117 to 2776 mL/min according to TTU; and 1564, 1566, and 119 to 3216 mL/min according to CDU. The intraclass correlation coefficient of portal venous flow between TTU and CDU was 0.68 (95% confidence interval, 0.51-0.80). The Bland-Altman plots revealed an average variation of 4.8% between TTU and CDU but with a rather wide 95% confidence interval of variation ranging from -57.7% to 67.4%. Intraoperative TTU and CDU showed moderate agreement in portal flow measurement. However, a relatively wide range of variation exists between TTU and CDU, indicating that data obtained from the 2 devices may not be interchangeable. Copyright © 2018 Elsevier Inc. All rights reserved.

Direct Measurements of Skin Friction

NASA Technical Reports Server (NTRS)

Dhawan, Satish

1953-01-01

A device has been developed to measure local skin friction on a flat plate by measuring the force exerted upon a very small movable part of the surface of the flat plate. These forces, which range from about 1 milligram to about 100 milligrams, are measured by means of a reactance device. The apparatus was first applied to measurements in the low-speed range, both for laminar and turbulent boundary layers. The measured skin-friction coefficients show excellent agreement with Blasius' and Von Karman's results. The device was then applied to high-speed subsonic flow and the turbulent-skin-friction coefficients were determined up to a Mach number of about 0.8. A few measurements in supersonic flow were also made. This paper describes the design and construction of the device and the results of the measurements.

A Mobile System for Measuring Water Surface Velocities Using Unmanned Aerial Vehicle and Large-Scale Particle Image Velocimetry

NASA Astrophysics Data System (ADS)

Chen, Y. L.

2015-12-01

Measurement technologies for velocity of river flow are divided into intrusive and nonintrusive methods. Intrusive method requires infield operations. The measuring process of intrusive methods are time consuming, and likely to cause damages of operator and instrument. Nonintrusive methods require fewer operators and can reduce instrument damages from directly attaching to the flow. Nonintrusive measurements may use radar or image velocimetry to measure the velocities at the surface of water flow. The image velocimetry, such as large scale particle image velocimetry (LSPIV) accesses not only the point velocity but the flow velocities in an area simultaneously. Flow properties of an area hold the promise of providing spatially information of flow fields. This study attempts to construct a mobile system UAV-LSPIV by using an unmanned aerial vehicle (UAV) with LSPIV to measure flows in fields. The mobile system consists of a six-rotor UAV helicopter, a Sony nex5T camera, a gimbal, an image transfer device, a ground station and a remote control device. The activate gimbal helps maintain the camera lens orthogonal to the water surface and reduce the extent of images being distorted. The image transfer device can monitor the captured image instantly. The operator controls the UAV by remote control device through ground station and can achieve the flying data such as flying height and GPS coordinate of UAV. The mobile system was then applied to field experiments. The deviation of velocities measured by UAV-LSPIV of field experiments and handhold Acoustic Doppler Velocimeter (ADV) is under 8%. The results of the field experiments suggests that the application of UAV-LSPIV can be effectively applied to surface flow studies.

Apparatus for passive removal of subsurface contaminants and mass flow measurement

DOEpatents

Jackson, Dennis G [Augusta, GA; Rossabi, Joseph [Aiken, SC; Riha, Brian D [Augusta, GA

2003-07-15

A system for improving the Baroball valve and a method for retrofitting an existing Baroball valve. This invention improves upon the Baroball valve by reshaping the interior chamber of the valve to form a flow meter measuring chamber. The Baroball valve sealing mechanism acts as a rotameter bob for determining mass flow rate through the Baroball valve. A method for retrofitting a Baroball valve includes providing static pressure ports and connecting a measuring device, to these ports, for measuring the pressure differential between the Baroball chamber and the well. A standard curve of nominal device measurements allows the mass flow rate to be determined through the retrofitted Baroball valve.

Apparatus for passive removal of subsurface contaminants and volume flow measurement

DOEpatents

Jackson, Dennis G.; Rossabi, Joseph; Riha, Brian D.

2002-01-01

A system for improving the Baroball valve and a method for retrofitting an existing Baroball valve. This invention improves upon the Baroball valve by reshaping the interior chamber of the valve to form a flow meter measuring chamber. The Baroball valve sealing mechanism acts as a rotameter bob for determining volume flow rate through the Baroball valve. A method for retrofitting a Baroball valve includes providing static pressure ports and connecting a measuring device, to these ports, for measuring the pressure differential between the Baroball chamber and the well. A standard curve of nominal device measurements allows the volume flow rate to be determined through the retrofitted Baroball valve.

[A capillary blood flow velocity detection system based on linear array charge-coupled devices].

PubMed

Zhou, Houming; Wang, Ruofeng; Dang, Qi; Yang, Li; Wang, Xiang

2017-12-01

In order to detect the flow characteristics of blood samples in the capillary, this paper introduces a blood flow velocity measurement system based on field-programmable gate array (FPGA), linear charge-coupled devices (CCD) and personal computer (PC) software structure. Based on the analysis of the TCD1703C and AD9826 device data sheets, Verilog HDL hardware description language was used to design and simulate the driver. Image signal acquisition and the extraction of the real-time edge information of the blood sample were carried out synchronously in the FPGA. Then a series of discrete displacement were performed in a differential operation to scan each of the blood samples displacement, so that the sample flow rate could be obtained. Finally, the feasibility of the blood flow velocity detection system was verified by simulation and debugging. After drawing the flow velocity curve and analyzing the velocity characteristics, the significance of measuring blood flow velocity is analyzed. The results show that the measurement of the system is less time-consuming and less complex than other flow rate monitoring schemes.

Computational and experimental studies of LEBUs at high device Reynolds numbers

NASA Technical Reports Server (NTRS)

Bertelrud, Arild; Watson, R. D.

1988-01-01

The present paper summarizes computational and experimental studies for large-eddy breakup devices (LEBUs). LEBU optimization (using a computational approach considering compressibility, Reynolds number, and the unsteadiness of the flow) and experiments with LEBUs at high Reynolds numbers in flight are discussed. The measurements include streamwise as well as spanwise distributions of local skin friction. The unsteady flows around the LEBU devices and far downstream are characterized by strain-gage measurements on the devices and hot-wire readings downstream. Computations are made with available time-averaged and quasi-stationary techniques to find suitable device profiles with minimum drag.

Evaluation of four fast-response flow measurement devices

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gero, A.J.; Suppers, K.L.; Tomb, T.F.

1988-01-01

The Federal Mine Safety and Health Act of 1977 requires that sampling of dust in coal mine environments be conducted with an approved sampler operating at a flow rate of 2.0 liters of air per minute or at such other flow rate as prescribed by the Secretaries of Labor and of Health and Human Services. Standard procedures for calibration of these samplers within the Mine Safety and Health Administration utilize either a 3.0 liter capacity wet test meter or a 1.0 liter soap film calibrator. Several new flow calibrating devices have become commercially available. This paper describes an evaluation conductedmore » on four such devices: the Mast Model 823-2 bubble flowmeter, the Buck Calibrator, the Kurz Model 541S mass flowmeter and the Kurz Pocket Calibrator. The precision of a series of measurements made with each instrument was compared to the precision of a series of measurements made with the wet test meter. The comparison showed that the variability of calibration measurements obtained with the fast response flow calibrators was between 1.5 and 4.5 times larger than that obtained with the WTM; however, with all of the calibration devices evaluated, three repetitive measurements were sufficient to obtain a precision of {plus minus}0.1 liters per minute. 4 refs., 2 figs., 1 tab.« less

40 CFR 98.154 - Monitoring and QA/QC requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... the concentrations of the process samples. (b) The mass flow of the product stream containing the HFC... concentration and volumetric flow rate determined by measurement of volumetric flow rate using EPA Method 2, 2A... volumetric flow rate at the inlet or by a metering device for HFC-23 sent to the device. Determine a new...

21 CFR 876.1800 - Urine flow or volume measuring system.

Code of Federal Regulations, 2010 CFR

2010-04-01

... volume measuring system. (a) Identification. A urine flow or volume measuring system is a device that measures directly or indirectly the volume or flow of urine from a patient, either during the course of... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Urine flow or volume measuring system. 876.1800...

Self-Contained Compressed-Flow Generation Device for Use in Making Differential Measurements

NASA Technical Reports Server (NTRS)

England, John Dwight (Inventor); Kelley, Anthony R. (Inventor); Cronise, Raymond J. (Inventor)

2014-01-01

A device used in making differential measurements of a flow includes a flow obstruction and a support arm. The flow obstruction's forward portion is a nose cone. The flow obstruction's aft portion is coupled to the nose cone. The support arm's first end is coupled to an exterior wall of a conduit, and its second end is coupled to the forward portion of the flow obstruction. The support arm positions the flow obstruction in the conduit such that a flow region is defined around its nose cone, and such that the support arm's first and second end are separated from one another with respect to a length dimension of the conduit. Measurement ports are provided in the support arm and flow obstruction. Manifolds extending through the flow obstruction and support arm couple the ports to points at the exterior wall of the conduit.

Device and method for measuring the energy content of hot and humid air streams

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rosen, H. N.; Girod, G. F.; Kent, A. C.

1985-12-24

a portable device and method for measuring enthalpy and humidity of humid air from a space or flow channel at temperatures from 80/sup 0/ to 400/sup 0/ F. is described. the device consists of a psychrometer for measuring wet-bulb temperature, a vacuum pump for inducing sample air flow through the unit, a water-heating system for accurate psychrometer readings, an electronic computer system for evaluation of enthalpy and humidity from corrected and averaged values of wet- and dry- bulb temperatures, and a monitor for displaying the values. The device is programmable by the user to modify evaluation methods as necessary.

A High-Speed Continuous Recording High Flow Gas Sampler for Measuring Methane Emissions from Pneumatic Devices at Oil and Natural Gas Production Facilities

NASA Astrophysics Data System (ADS)

Ferrara, T.; Howard, T. M.

2016-12-01

Studies attempting to reconcile facility level emission estimates of sources at oil and gas facilities with basin wide methane flux measurements have had limited success. Pneumatic devices are commonly used at oil and gas production facilities for process control or liquid pumping. These devices are powered by pressurized natural gas from the well, so they are known methane sources at these sites. Pneumatic devices are estimated to contribute 14% to 25% of the total greenhouse gas emissions (GHG) from production facilities. Measurements of pneumatic devices have shown that malfunctioning or poorly maintained control systems may be emitting significantly more methane than currently estimated. Emission inventories for these facilities use emission factors from EPA that are based on pneumatic device measurements made in the early 1990's. Recent studies of methane emissions from production facilities have attempted to measure emissions from pneumatic devices by several different methods. These methods have had limitations including alteration of the system being measured, the inability to distinguish between leaks and venting during normal operation, or insufficient response time to account of the time based emission events. We have developed a high speed recording high flow sampler that is capable of measuring the transient emissions from pneumatic devices. This sampler is based on the well-established high flow measurement technique used in oil and gas for quantifying component leak rates. In this paper we present the results of extensive laboratory controlled release testing. Additionally, test data from several field studies where this sampler has been used to measure pneumatic device emissions will be presented.

Fabrication of microfluidic architectures for optimal flow rate and concentration measurement for lab on chip application

NASA Astrophysics Data System (ADS)

Adam, Tijjani; Hashim, U.

2017-03-01

Optimum flow in micro channel for sensing purpose is challenging. In this study, The optimizations of the fluid sample flows are made through the design and characterization of the novel microfluidics' architectures to achieve the optimal flow rate in the micro channels. The biocompatibility of the Polydimetylsiloxane (Sylgard 184 silicon elastomer) polymer used to fabricate the device offers avenue for the device to be implemented as the universal fluidic delivery system for bio-molecules sensing in various bio-medical applications. The study uses the following methodological approaches, designing a novel microfluidics' architectures by integrating the devices on a single 4 inches silicon substrate, fabricating the designed microfluidic devices using low-cost solution soft lithography technique, characterizing and validating the flow throughput of urine samples in the micro channels by generating pressure gradients through the devices' inlets. The characterization on the urine samples flow in the micro channels have witnessed the constant flow throughout the devices.

Quality Control Method for a Micro-Nano-Channel Microfabricated Device

NASA Technical Reports Server (NTRS)

Grattoni, Alessandro; Ferrari, Mauro; Li, Xuewu

2012-01-01

A variety of silicon-fabricated devices is used in medical applications such as drug and cell delivery, and DNA and protein separation and analysis. When a fluidic device inlet is connected to a compressed gas reservoir, and the outlet is at a lower pressure, a gas flow occurs through the membrane toward the outside. The method relies on the measurement of the gas pressure over the elapsed time inside the upstream and downstream environments. By knowing the volume of the upstream reservoir, the gas flow rate through the membrane over the pressure drop can be calculated. This quality control method consists of measuring the gas flow through a device and comparing the results with a standard curve, which can be obtained by testing standard devices. Standard devices can be selected through a variety of techniques, both destructive and nondestructive, such as SEM, AFM, and standard particle filtration.

Fluid flow sensing with ionic polymer-metal composites

NASA Astrophysics Data System (ADS)

Stalbaum, Tyler; Trabia, Sarah; Shen, Qi; Kim, Kwang J.

2016-04-01

Ionic polymer-metal composite (IPMC) actuators and sensors have been developed and modeled over the last two decades for use as soft-robotic deformable actuators and sensors. IPMC devices have been suggested for application as underwater actuators, energy harvesting devices, and medical devices such as in guided catheter insertion. Another interesting application of IPMCs in flow sensing is presented in this study. IPMC interaction with fluid flow is of interest to investigate the use of IPMC actuators as flow control devices and IPMC sensors as flow sensing devices. An organized array of IPMCs acting as interchanging sensors and actuators could potentially be designed for both flow measurement and control, providing an unparalleled tool in maritime operations. The underlying physics for this system include the IPMC ion transport and charge fundamental framework along with fluid dynamics to describe the flow around IPMCs. An experimental setup for an individual rectangular IPMC sensor with an externally controlled fluid flow has been developed to investigate this phenomenon and provide further insight into the design and application of this type of device. The results from this portion of the study include recommendations for IPMC device designs in flow control.

Heat flow calorimeter. [measures output of Ni-Cd batteries

NASA Technical Reports Server (NTRS)

Fletcher, J. C.; Johnston, W. V. (Inventor)

1974-01-01

Heat flow calorimeter devices are used to measure heat liberated from or absorbed by an object. This device is capable of measuring the thermal output of sealed nickel-cadmium batteries or cells during charge-discharge cycles. An elongated metal heat conducting rod is coupled between the calorimeter vessel and a heat sink, thus providing the only heat exchange path from the calorimeter vessel itself.

Flow-Field Measurement of Device-Induced Embedded Streamwise Vortex on a Flat Plate

NASA Technical Reports Server (NTRS)

Yao, Chung-Sheng; Lin, John C.; Allan, Brian G.

2002-01-01

Detailed flow-field measurements were performed downstream of a single vortex generator (VG) using an advanced Stereo Digital Particle Image Velocimetry system. Thc passive flow-control devices examined consisted of a low-profile VG with a device height, h, approximately equal to 20 percent of the boundary-layer thickness, sigma, and a conventional VG with h is approximately sigma. Flow-field data were taken at twelve cross-flow planes downstream of the VG to document and quantify the evolution of embedded streamwise vortex. The effects of device angle of attack on vortex development downstream were compared between the low-profile VG and the conventional VG. Key parameters including vorticity, circulation, trajectory, and half-life radius - describing concentration, strength, path, and size, respectively--of the device-induced streamwise vortex were extracted from the flow-field data. The magnitude of maximum vorticity increases as angle of attack increases for the low-profile VG, but the trend is reversed for the conventional VG, probably due to flow stalling around the larger device at higher angles of attack. Peak vorticity and circulation for the low-profile VG decays exponentially and inversely proportional to the distance downstream from the device. The device-height normalized vortex trajectories for the low-profile VG, especially in the lateral direction, follow the general trends of the conventional VG. The experimental database was used to validate the predictive capability of computational fluid dynamics (CFD). CFD accurately predicts the vortex circulation and path; however, improvements are needed for predicting the vorticity strength and vortex size.

A microfluidic device for simultaneous measurement of viscosity and flow rate of blood in a complex fluidic network

PubMed Central

Jun Kang, Yang; Yeom, Eunseop; Lee, Sang-Joon

2013-01-01

Blood viscosity has been considered as one of important biophysical parameters for effectively monitoring variations in physiological and pathological conditions of circulatory disorders. Standard previous methods make it difficult to evaluate variations of blood viscosity under cardiopulmonary bypass procedures or hemodialysis. In this study, we proposed a unique microfluidic device for simultaneously measuring viscosity and flow rate of whole blood circulating in a complex fluidic network including a rat, a reservoir, a pinch valve, and a peristaltic pump. To demonstrate the proposed method, a twin-shaped microfluidic device, which is composed of two half-circular chambers, two side channels with multiple indicating channels, and one bridge channel, was carefully designed. Based on the microfluidic device, three sequential flow controls were applied to identify viscosity and flow rate of blood, with label-free and sensorless detection. The half-circular chamber was employed to achieve mechanical membrane compliance for flow stabilization in the microfluidic device. To quantify the effect of flow stabilization on flow fluctuations, a formula of pulsation index (PI) was analytically derived using a discrete fluidic circuit model. Using the PI formula, the time constant contributed by the half-circular chamber is estimated to be 8 s. Furthermore, flow fluctuations resulting from the peristaltic pumps are completely removed, especially under periodic flow conditions within short periods (T < 10 s). For performance demonstrations, the proposed method was applied to evaluate blood viscosity with respect to varying flow rate conditions [(a) known blood flow rate via a syringe pump, (b) unknown blood flow rate via a peristaltic pump]. As a result, the flow rate and viscosity of blood can be simultaneously measured with satisfactory accuracy. In addition, the proposed method was successfully applied to identify the viscosity of rat blood, which circulates in a complex fluidic network. These observations confirm that the proposed method can be used for simultaneous measurement of viscosity and flow rate of whole blood circulating in the complex fluid network, with sensorless and label-free detection. Furthermore, the proposed method will be used in evaluating variations in the viscosity of human blood during cardiopulmonary bypass procedures or hemodialysis. PMID:24404074

A microfluidic device for simultaneous measurement of viscosity and flow rate of blood in a complex fluidic network.

PubMed

Jun Kang, Yang; Yeom, Eunseop; Lee, Sang-Joon

2013-01-01

Blood viscosity has been considered as one of important biophysical parameters for effectively monitoring variations in physiological and pathological conditions of circulatory disorders. Standard previous methods make it difficult to evaluate variations of blood viscosity under cardiopulmonary bypass procedures or hemodialysis. In this study, we proposed a unique microfluidic device for simultaneously measuring viscosity and flow rate of whole blood circulating in a complex fluidic network including a rat, a reservoir, a pinch valve, and a peristaltic pump. To demonstrate the proposed method, a twin-shaped microfluidic device, which is composed of two half-circular chambers, two side channels with multiple indicating channels, and one bridge channel, was carefully designed. Based on the microfluidic device, three sequential flow controls were applied to identify viscosity and flow rate of blood, with label-free and sensorless detection. The half-circular chamber was employed to achieve mechanical membrane compliance for flow stabilization in the microfluidic device. To quantify the effect of flow stabilization on flow fluctuations, a formula of pulsation index (PI) was analytically derived using a discrete fluidic circuit model. Using the PI formula, the time constant contributed by the half-circular chamber is estimated to be 8 s. Furthermore, flow fluctuations resulting from the peristaltic pumps are completely removed, especially under periodic flow conditions within short periods (T < 10 s). For performance demonstrations, the proposed method was applied to evaluate blood viscosity with respect to varying flow rate conditions [(a) known blood flow rate via a syringe pump, (b) unknown blood flow rate via a peristaltic pump]. As a result, the flow rate and viscosity of blood can be simultaneously measured with satisfactory accuracy. In addition, the proposed method was successfully applied to identify the viscosity of rat blood, which circulates in a complex fluidic network. These observations confirm that the proposed method can be used for simultaneous measurement of viscosity and flow rate of whole blood circulating in the complex fluid network, with sensorless and label-free detection. Furthermore, the proposed method will be used in evaluating variations in the viscosity of human blood during cardiopulmonary bypass procedures or hemodialysis.

In microfluidico: Recreating in vivo hemodynamics using miniaturized devices

PubMed Central

Zhu, Shu; Herbig, Bradley A.; Li, Ruizhi; Colace, Thomas V.; Muthard, Ryan W.; Neeves, Keith B.; Diamond, Scott L.

2016-01-01

Microfluidic devices create precisely controlled reactive blood flows and typically involve: (i) validated anticoagulation/pharmacology protocols, (ii) defined reactive surfaces, (iii) defined flow-transport regimes, and (iv) optical imaging. An 8-channel device can be run at constant flow rate or constant pressure drop for blood perfusion over a patterned collagen, collagen/kaolin, or collagen/tissue factor (TF) to measure platelet, thrombin, and fibrin dynamics during clot growth. A membrane-flow device delivers a constant flux of platelet agonists or coagulation enzymes into flowing blood. A trifurcated device sheaths a central blood flow on both sides with buffer, an ideal approach for on-chip recalcification of citrated blood or drug delivery. A side-view device allows clotting on a porous collagen/TF plug at constant pressure differential across the developing clot. The core-shell architecture of clots made in mouse models can be replicated in this device using human blood. For pathological flows, a stenosis device achieves shear rates of >100,000 s−1 to drive plasma von Willebrand factor (VWF) to form thick long fibers on collagen. Similarly, a micropost-impingement device creates extreme elongational and shear flows for VWF fiber formation without collagen. Overall, microfluidics are ideal for studies of clotting, bleeding, fibrin polymerization/fibrinolysis, cell/clot mechanics, adhesion, mechanobiology, and reaction-transport dynamics. PMID:26600269

Investigating fast enzyme-DNA kinetics using multidimensional fluorescence imaging and microfluidics

NASA Astrophysics Data System (ADS)

Robinson, Tom; Manning, Hugh B.; Dunsby, Christopher; Neil, Mark A. A.; Baldwin, Geoff S.; de Mello, Andrew J.; French, Paul M. W.

2010-02-01

We have developed a rapid microfluidic mixing device to image fast kinetics. To verify the performance of the device it was simulated using computational fluid dynamics (CFD) and the results were directly compared to experimental fluorescence lifetime imaging (FLIM) measurements. The theoretical and measured mixing times of the device were found to be in agreement over a range of flow rates. This mixing device is being developed with the aim of analysing fast enzyme kinetics in the sub-millisecond time domain, which cannot be achieved with conventional macro-stopped flow devices. Here we have studied the binding of a DNA repair enzyme, uracil DNA glycosylase (UDG), to a fluorescently labelled DNA substrate. Bulk phase fluorescence measurements have been used to measure changes on binding: it was found that the fluorescence lifetime increased along with an increase in the polarisation anisotropy and rotational correlation time. Analysis of the same reaction in the microfluidic mixer by CFD enabled us to predict the mixing time of the device to be 46 μs, more than 20 times faster than current stopped-flow techniques. We also demonstrate that it is possible to image UDG-DNA interactions within the micromixer using the signal changes observed from the multidimensional spectrofluorometer.

Verification of a computational cardiovascular system model comparing the hemodynamics of a continuous flow to a synchronous valveless pulsatile flow left ventricular assist device.

PubMed

Gohean, Jeffrey R; George, Mitchell J; Pate, Thomas D; Kurusz, Mark; Longoria, Raul G; Smalling, Richard W

2013-01-01

The purpose of this investigation is to use a computational model to compare a synchronized valveless pulsatile left ventricular assist device with continuous flow left ventricular assist devices at the same level of device flow, and to verify the model with in vivo porcine data. A dynamic system model of the human cardiovascular system was developed to simulate the support of a healthy or failing native heart from a continuous flow left ventricular assist device or a synchronous pulsatile valveless dual-piston positive displacement pump. These results were compared with measurements made during in vivo porcine experiments. Results from the simulation model and from the in vivo counterpart show that the pulsatile pump provides higher cardiac output, left ventricular unloading, cardiac pulsatility, and aortic valve flow as compared with the continuous flow model at the same level of support. The dynamic system model developed for this investigation can effectively simulate human cardiovascular support by a synchronous pulsatile or continuous flow ventricular assist device.

Verification of a computational cardiovascular system model comparing the hemodynamics of a continuous flow to a synchronous valveless pulsatile flow left ventricular assist device

PubMed Central

Gohean, Jeffrey R.; George, Mitchell J.; Pate, Thomas D.; Kurusz, Mark; Longoria, Raul G.; Smalling, Richard W.

2012-01-01

The purpose of this investigation is to utilize a computational model to compare a synchronized valveless pulsatile left ventricular assist device to continuous flow left ventricular assist devices at the same level of device flow, and to verify the model with in vivo porcine data. A dynamic system model of the human cardiovascular system was developed to simulate support of a healthy or failing native heart from a continuous flow left ventricular assist device or a synchronous, pulsatile, valveless, dual piston positive displacement pump. These results were compared to measurements made during in vivo porcine experiments. Results from the simulation model and from the in vivo counterpart show that the pulsatile pump provides higher cardiac output, left ventricular unloading, cardiac pulsatility, and aortic valve flow as compared to the continuous flow model at the same level of support. The dynamic system model developed for this investigation can effectively simulate human cardiovascular support by a synchronous pulsatile or continuous flow ventricular assist device. PMID:23438771

Comparison of spatio-temporal resolution of different flow measurement techniques for marine renewable energy applications

NASA Astrophysics Data System (ADS)

Lyon, Vincent; Wosnik, Martin

2013-11-01

Marine hydrokinetic (MHK) energy conversion devices are subject to a wide range of turbulent scales, either due to upstream bathymetry, obstacles and waves, or from wakes of upstream devices in array configurations. The commonly used, robust Acoustic Doppler Current Profilers (ADCP) are well suited for long term flow measurements in the marine environment, but are limited to low sampling rates due to their operational principle. The resulting temporal and spatial resolution is insufficient to measure all turbulence scales of interest to the device, e.g., ``blade-scale turbulence.'' The present study systematically characterizes the spatial and temporal resolution of ADCP, Acoustic Doppler Velocimetry (ADV), and Particle Image Velocimetry (PIV). Measurements were conducted in a large cross section tow tank (3.7m × 2.4m) for several benchmark cases, including low and high turbulence intensity uniform flow as well as in the wake of a cylinder, to quantitatively investigate the flow scales which each of the instruments can resolve. The purpose of the study is to supply data for mathematical modeling to improve predictions from ADCP measurements, which can help lead to higher-fidelity energy resource assessment and more accurate device evaluation, including wake measurements. Supported by NSF-CBET grant 1150797.

[Self-active physical thrombosis prophylaxis in the patients' bed with the Phlebostep: acceptance and measurement of venous blood flow in immobilized patients].

PubMed

Olivier, L C; Ostovan, D; Heywinkel, W; Kendoff, D; Wolfhard, U

2007-11-01

Despite the broad use of low molecular weight heparin, deep vein thrombosis is still a relevant risk for immobilized patients in orthopedic surgery. Patients can reduce this risk by active training exercises with a muscle pump. The aim of this study was to test the acceptance and effect of a self-developed training device to accelerate venous return as well as a technical optimization. The device was installed for in-patients in orthopedic and traumatology departments. A simple pillow-like device was developed, which can be positioned against the foot end of the patient's bed (Phlebostep). The device gives a sound-based feedback to the patient while pushing actively against it with complete ankle flexion. A digital integrated counter device allows direct feedback to the physician and nursing staff at any time. Initial testing including duplex sonography for venous flow measurements were done on 10 orthopedic in-patients. Prior testing on 7 healthy volunteers was carried out to define the effect of various amounts of pressure on the Phlebostep on the venous blood flow. Additionally, a questionnaire on the general acceptance and user-friendliness was filled out by 84 patients who had used the Phlebostep. The optimal pressure force was defined as 35 mmHg for further measurements. The venous flow measurements in the 10 postoperative patients revealed an increased venous blood flow in the affected leg by an average of 99.9%. Analysis of the questionnaire from the 84 patients showed a high degree of acceptance. In addition to the technical feasibility, this study showed that use of the Phlebostep resulted on average in a doubling of venous return. The increase of venous flow offers an additional effective device for thrombosis prophylaxis through patient's own active movements and is clearly superior to the use of devices such as antithrombosis stockings alone. The Phlebostep found a high degree of acceptance with the patients.

An automatic bolus injector for use in radiotracer studies of blood flow: design and evaluation.

PubMed

Snyder, R E; Overton, T R; Boisvert, D P; Petruk, K C

1976-12-01

An electromechanical device is described which automatically injects the radiotracer bolus used in the measurement of cerebral blood flow. It consists of two electronically controlled, solenoid operated syringes, one containing the radiotracer solution and the other heparinized saline. Results are presented which show that use of the automatic bolus injector in place of hand injection leads to an improvement in the precision of measured flow values. Additional advantages of the device are discussed.

Micromachined lab-on-a-tube sensors for simultaneous brain temperature and cerebral blood flow measurements.

PubMed

Li, Chunyan; Wu, Pei-Ming; Hartings, Jed A; Wu, Zhizhen; Cheyuo, Cletus; Wang, Ping; LeDoux, David; Shutter, Lori A; Ramaswamy, Bharat Ram; Ahn, Chong H; Narayan, Raj K

2012-08-01

This work describes the development of a micromachined lab-on-a-tube device for simultaneous measurement of brain temperature and regional cerebral blood flow. The device consists of two micromachined gold resistance temperature detectors with a 4-wire configuration. One is used as a temperature sensor and the other as a flow sensor. The temperature sensor operates with AC excitation current of 500 μA and updates its outputs at a rate of 5 Hz. The flow sensor employs a periodic heating and cooling technique under constant-temperature mode and updates its outputs at a rate of 0.1 Hz. The temperature sensor is also used to compensate for temperature changes during the heating period of the flow sensor to improve the accuracy of flow measurements. To prevent thermal and electronic crosstalk between the sensors, the temperature sensor is located outside the "thermal influence" region of the flow sensor and the sensors are separated into two different layers with a thin-film Copper shield. We evaluated the sensors for accuracy, crosstalk and long-term drift in human blood-stained cerebrospinal fluid. These in vitro experiments showed that simultaneous temperature and flow measurements with a single lab-on-a-tube device are accurate and reliable over the course of 5 days. It has a resolution of 0.013 °C and 0.18 ml/100 g/min; and achieves an accuracy of 0.1 °C and 5 ml/100 g/min for temperature and flow sensors respectively. The prototype device and techniques developed here establish a foundation for a multi-sensor lab-on-a-tube, enabling versatile multimodality monitoring applications.

A measurement device for electromagnetic flow tomography

NASA Astrophysics Data System (ADS)

Vauhkonen, M.; Hänninen, A.; Lehtikangas, O.

2018-01-01

Electromagnetic flow meters have succesfully been used in many industries to measure the mean flow velocity of conductive liquids. This technology works reliably in single phase flows with axisymmetric flow profiles but can be inaccurate with asymmetric flows, which are encountered, for example, in multiphase flows, pipe elbows and T-junctions. Some computational techniques and measurement devices with multiple excitation coils and measurement electrodes have recently been proposed to be used in cases of asymmetric flows. In earlier studies, we proposed a computational approach for electromagnetic flow tomography (EMFT) for estimating velocity fields utilizing several excitation coils and a set of measurement electrodes attached to the surface of the pipe. This approach has been shown to work well with simulated data but has not been tested extensively with real measurements. In this paper, an EMFT system with four excitation coils and 16 measurement electrodes is introduced. The system is capable of using both square wave and sinusoidal coil current excitations and all the coils can be excited individually, also enabling parallel excitations with multiple frequencies. The studies undertaken in the paper demonstrate that the proposed EMFT system, together with the earlier introduced velocity field reconstruction approach, is capable of producing reliable velocify field estimates in a laboratory environment with both axisymmetric and asymmetric single phase flows.

Phloem-sap-dynamics sensor device for monitoring photosynthates transportation in plant shoots

NASA Astrophysics Data System (ADS)

Yano, Yuya; Ono, Akihito; Terao, Kyohei; Suzuki, Takaaki; Takao, Hidekuni; Kobayashi, Tsuyoshi; Kataoka, Ikuo; Shimokawa, Fusao

2018-06-01

We propose a microscale phloem-sap-dynamics sensor device to obtain the index of an internal plant condition regarding the transportation of primary photosynthates in phloem, which is an essential indicator of stable crop production under controlled-growth environments. In detail, we integrated a conventional Granier sensor with a thermal-flow sensor and devised an improved sensor device to quantify such index, including the information on velocity and direction of the phloem-sap flow using the microelectromechanical systems (MEMS) technology. The experimental results showed that although the proposed sensor device was approximately only 1/10 the size of the conventional Granier sensor, it could generate an output nearly equal to that of the conventional sensor. Furthermore, experiments using mimicked plants demonstrated that the proposed device could measure minute flow velocities in the range of 0–200 µm/s, which are generally known as the phloem-sap flow velocity, and simultaneously detect the flow direction.

A microfluidic needle for sampling and delivery of chemical signals by segmented flows

NASA Astrophysics Data System (ADS)

Feng, Shilun; Liu, Guozhen; Jiang, Lianmei; Zhu, Yonggang; Goldys, Ewa M.; Inglis, David W.

2017-10-01

We have developed a microfluidic needle-like device that can extract and deliver nanoliter samples. The device consists of a T-junction to form segmented flows, parallel channels to and from the needle tip, and seven hydrophilic capillaries at the tip that form a phase-extraction region. The main microchannel is hydrophobic and carries segmented flows of water-in-oil. The hydrophilic capillaries transport the aqueous phase with a nearly zero pressure gradient but require a pressure gradient of 19 kPa for mineral oil to invade and flow through. Using this device, we demonstrate the delivery of nanoliter droplets and demonstrate sampling through the formation of droplets at the tip of our device. During sampling, we recorded the fluorescence intensities of the droplets formed at the tip while varying the concentration of dye outside the tip. We measured a chemical signal response time of approximately 3 s. The linear relationship between the recorded fluorescence intensity of samples and the external dye concentration (10-40 μg/ml) indicates that this device is capable of performing quantitative, real-time measurements of rapidly varying chemical signals.

Cross-correlation-based transverse flow measurements using optical resolution photoacoustic microscopy with a digital micromirror device.

PubMed

Liang, Jinyang; Zhou, Yong; Maslov, Konstantin I; Wang, Lihong V

2013-09-01

A cross-correlation-based method is proposed to quantitatively measure transverse flow velocity using optical resolution photoacoustic (PA) microscopy enhanced with a digital micromirror device (DMD). The DMD is used to alternately deliver two spatially separated laser beams to the target. Through cross-correlation between the slow-time PA profiles measured from the two beams, the speed and direction of transverse flow are simultaneously derived from the magnitude and sign of the time shift, respectively. Transverse flows in the range of 0.50 to 6.84  mm/s are accurately measured using an aqueous suspension of 10-μm-diameter microspheres, and the root-mean-squared measurement accuracy is quantified to be 0.22  mm/s. The flow measurements are independent of the particle size for flows in the velocity range of 0.55 to 6.49  mm/s, which was demonstrated experimentally using three different sizes of microspheres (diameters: 3, 6, and 10 μm). The measured flow velocity follows an expected parabolic distribution along the depth direction perpendicular to the flow. Both maximum and minimum measurable velocities are investigated for varied distances between the two beams and varied total time for one measurement. This technique shows an accuracy of 0.35  mm/s at 0.3-mm depth in scattering chicken breast, making it promising for measuring flow in biological tissue.

18 CFR 806.25 - Water conservation standards.

Code of Federal Regulations, 2012 CFR

2012-04-01

..., as applicable, by all classes of users. (ii) Prepare and distribute literature to customers... meters or other suitable devices or utilize acceptable flow measuring methods for accurate determination of water use by various parts of the company operation. (3) Install flow control devices which match...

18 CFR 806.25 - Water conservation standards.

Code of Federal Regulations, 2013 CFR

2013-04-01

..., as applicable, by all classes of users. (ii) Prepare and distribute literature to customers... meters or other suitable devices or utilize acceptable flow measuring methods for accurate determination of water use by various parts of the company operation. (3) Install flow control devices which match...

18 CFR 806.25 - Water conservation standards.

Code of Federal Regulations, 2014 CFR

2014-04-01

..., as applicable, by all classes of users. (ii) Prepare and distribute literature to customers... meters or other suitable devices or utilize acceptable flow measuring methods for accurate determination of water use by various parts of the company operation. (3) Install flow control devices which match...

Echocardiographic predictors of coil vs device closure in patients undergoing percutaneous patent ductus arteriosus closure.

PubMed

Roushdy, Alaa; Abd El Razek, Yasmeen; Mamdouh Tawfik, Ahmed

2018-01-01

To determine anatomic and hemodynamic echocardiographic predictors for patent ductus arteriosus (PDA) device vs coil closure. Seventy-six patients who were referred for elective transcatheter PDA closure were enrolled in the study. All patients underwent full echocardiogram including measurement of the PDA pulmonary end diameter, color flow width and extent, peak and end-diastolic Doppler gradients across the duct, diastolic flow reversal, left atrial dimensions and volume, left ventricular sphericity index, and volumes. The study group was subdivided into 2 subgroups based on the mode of PDA closure whether by coil (n = 42) or device (n = 34). Using univariate analysis there was a highly significant difference between the 2 groups as regard the pulmonary end diameter measured in both the suprasternal and parasternal short-axis views as well as the color flow width and color flow extent (P < .0001). The device closure group had statistically significant higher end-systolic and end-diastolic volumes indexed, left atrial volume, and diastolic flow reversal. Receiver operating characteristic curve analysis showed a pulmonary end diameter cutoff point from the suprasternal view > 2.5 mm and from parasternal short-axis view > 2.61 mm to have the highest balanced sensitivity and specificity to predict the likelihood for device closure (AUC 0.971 and 0.979 respectively). The pulmonary end diameter measured from the suprasternal view was the most independent predictor of device closure. The selection between PDA coil or device closure can be done on the basis of multiple anatomic and hemodynamic echocardiographic variables. © 2017 Wiley Periodicals, Inc.

Local wall heat flux/temperature meter for convective flow and method of utilizing same

DOEpatents

Boyd, Ronald D.; Ekhlassi, Ali; Cofie, Penrose

2004-11-30

According to one embodiment of the invention, a method includes providing a conduit having a fluid flowing therethrough, disposing a plurality of temperature measurement devices inside a wall of the conduit, positioning at least some of the temperature measurement devices proximate an inside surface of the wall of the conduit, positioning at least some of the temperature measurement devices at different radial positions at the same circumferential location within the wall, measuring a plurality of temperatures of the wall with respective ones of the temperature measurement devices to obtain a three-dimensional temperature topology of the wall, determining the temperature dependent thermal conductivity of the conduit, and determining a multi-dimensional thermal characteristic of the inside surface of the wall of the conduit based on extrapolation of the three-dimensional temperature topology and the temperature dependent thermal conductivities.

Local wall heat flux/temperature meter for convective flow and method of utilizing same

NASA Technical Reports Server (NTRS)

Cofie, Penrose (Inventor); Ekhlassi, Ali (Inventor); Boyd, Ronald D. (Inventor)

2004-01-01

According to one embodiment of the invention, a method includes providing a conduit having a fluid flowing therethrough, disposing a plurality of temperature measurement devices inside a wall of the conduit, positioning at least some of the temperature measurement devices proximate an inside surface of the wall of the conduit, positioning at least some of the temperature measurement devices at different radial positions at the same circumferential location within the wall, measuring a plurality of temperatures of the wall with respective ones of the temperature measurement devices to obtain a three-dimensional temperature topology of the wall, determining the temperature dependent thermal conductivity of the conduit, and determining a multi-dimensional thermal characteristic of the inside surface of the wall of the conduit based on extrapolation of the three-dimensional temperature topology and the temperature dependent thermal conductivities.

Design and implementation of a smartphone-based portable ultrasound pulsed-wave Doppler device for blood flow measurement.

PubMed

Huang, Chih-Chung; Lee, Po-Yang; Chen, Pay-Yu; Liu, Ting-Yu

2012-01-01

Blood flow measurement using Doppler ultrasound has become a useful tool for diagnosing cardiovascular diseases and as a physiological monitor. Recently, pocket-sized ultrasound scanners have been introduced for portable diagnosis. The present paper reports the implementation of a portable ultrasound pulsed-wave (PW) Doppler flowmeter using a smartphone. A 10-MHz ultrasonic surface transducer was designed for the dynamic monitoring of blood flow velocity. The directional baseband Doppler shift signals were obtained using a portable analog circuit system. After hardware processing, the Doppler signals were fed directly to a smartphone for Doppler spectrogram analysis and display in real time. To the best of our knowledge, this is the first report of the use of this system for medical ultrasound Doppler signal processing. A Couette flow phantom, consisting of two parallel disks with a 2-mm gap, was used to evaluate and calibrate the device. Doppler spectrograms of porcine blood flow were measured using this stand-alone portable device under the pulsatile condition. Subsequently, in vivo portable system verification was performed by measuring the arterial blood flow of a rat and comparing the results with the measurement from a commercial ultrasound duplex scanner. All of the results demonstrated the potential for using a smartphone as a novel embedded system for portable medical ultrasound applications. © 2012 IEEE

A mercury flow meter for ion thruster testing. [response time, thermal sensitivity

NASA Technical Reports Server (NTRS)

Wilbur, P. J.

1973-01-01

The theory of operation of the thermal flow meter is presented, and a theoretical model is used to determine design parameters for a device capable of measuring mercury flows in the range of 0 to 5 gm/hr. Flow meter construction is described. Tests performed using a positive displacement mercury pump as well as those performed with the device in the feed line of an operating thruster are discussed. A flow meter response time of about a minute and a sensitivity of about 10 mv/gm/hr are demonstrated. Additional work to relieve a sensitivity of the device to variations in ambient temperature is indicated to improve its quantitative performance.

Fluid flow monitoring device

DOEpatents

McKay, M.D.; Sweeney, C.E.; Spangler, B.S. Jr.

1993-11-30

A flow meter and temperature measuring device are described comprising a tube with a body centered therein for restricting flow and a sleeve at the upper end of the tube to carry several channels formed longitudinally in the sleeve to the appropriate axial location where they penetrate the tube to allow pressure measurements and temperature measurements with thermocouples. The high pressure measurement is made using a channel penetrating the tube away from the body and the low pressure measurement is made at a location at the widest part of the body. An end plug seals the end of the device and holes at its upper end allow fluid to pass from the interior of the tube into a plenum. The channels are made by cutting grooves in the sleeve, the grooves widened at the surface of the sleeve and then a strip of sleeve material is welded to the grooves closing the channels. Preferably the sleeve is packed with powdered graphite before cutting the grooves and welding the strips. 7 figures.

Ion heating and flows in a high power helicon source

NASA Astrophysics Data System (ADS)

Thompson, Derek S.; Agnello, Riccardo; Furno, Ivo; Howling, Alan; Jacquier, Rémy; Plyushchev, Gennady; Scime, Earl E.

2017-06-01

We report experimental measurements of ion temperatures and flows in a high power, linear, magnetized, helicon plasma device, the Resonant Antenna Ion Device (RAID). Parallel and perpendicular ion temperatures on the order of 0.6 eV are observed for an rf power of 4 kW, suggesting that higher power helicon sources should attain ion temperatures in excess of 1 eV. The unique RAID antenna design produces broad, uniform plasma density and perpendicular ion temperature radial profiles. Measurements of the azimuthal flow indicate rigid body rotation of the plasma column of a few kHz. When configured with an expanding magnetic field, modest parallel ion flows are observed in the expansion region. The ion flows and temperatures are derived from laser induced fluorescence measurements of the Doppler resolved velocity distribution functions of argon ions.

A simple method for the evaluation of microfluidic architecture using flow quantitation via a multiplexed fluidic resistance measurement.

PubMed

Leslie, Daniel C; Melnikoff, Brett A; Marchiarullo, Daniel J; Cash, Devin R; Ferrance, Jerome P; Landers, James P

2010-08-07

Quality control of microdevices adds significant costs, in time and money, to any fabrication process. A simple, rapid quantitative method for the post-fabrication characterization of microchannel architecture using the measurement of flow with volumes relevant to microfluidics is presented. By measuring the mass of a dye solution passed through the device, it circumvents traditional gravimetric and interface-tracking methods that suffer from variable evaporation rates and the increased error associated with smaller volumes. The multiplexed fluidic resistance (MFR) measurement method measures flow via stable visible-wavelength dyes, a standard spectrophotometer and common laboratory glassware. Individual dyes are used as molecular markers of flow for individual channels, and in channel architectures where multiple channels terminate at a common reservoir, spectral deconvolution reveals the individual flow contributions. On-chip, this method was found to maintain accurate flow measurement at lower flow rates than the gravimetric approach. Multiple dyes are shown to allow for independent measurement of multiple flows on the same device simultaneously. We demonstrate that this technique is applicable for measuring the fluidic resistance, which is dependent on channel dimensions, in four fluidically connected channels simultaneously, ultimately determining that one chip was partially collapsed and, therefore, unusable for its intended purpose. This method is thus shown to be widely useful in troubleshooting microfluidic flow characteristics.

Design and application of a fish-shaped lateral line probe for flow measurement

NASA Astrophysics Data System (ADS)

Tuhtan, J. A.; Fuentes-Pérez, J. F.; Strokina, N.; Toming, G.; Musall, M.; Noack, M.; Kämäräinen, J. K.; Kruusmaa, M.

2016-04-01

We introduce the lateral line probe (LLP) as a measurement device for natural flows. Hydraulic surveys in rivers and hydraulic structures are currently based on time-averaged velocity measurements using propellers or acoustic Doppler devices. The long-term goal is thus to develop a sensor system, which includes spatial gradients of the flow field along a fish-shaped sensor body. Interpreting the biological relevance of a collection of point velocity measurements is complicated by the fact that fish and other aquatic vertebrates experience the flow field through highly dynamic fluid-body interactions. To collect body-centric flow data, a bioinspired fish-shaped probe is equipped with a lateral line pressure sensing array, which can be applied both in the laboratory and in the field. Our objective is to introduce a new type of measurement device for body-centric data and compare its output to estimates of conventional point-based technologies. We first provide the calibration workflow for laboratory investigations. We then provide a review of two velocity estimation workflows, independent of calibration. Such workflows are required as existing field investigations consist of measurements in environments where calibration is not feasible. The mean difference for uncalibrated LLP velocity estimates from 0 to 50 cm/s under in a closed flow tunnel and open channel flume was within 4 cm/s when compared to conventional measurement techniques. Finally, spatial flow maps in a scale vertical slot fishway are compared for the LLP, direct measurements, and 3D numerical models where it was found that the LLP provided a slight overestimation of the current velocity in the jet and underestimated the velocity in the recirculation zone.

[Effects of breathing exercises on breathing pattern and thoracoabdominal motion after gastroplasty].

PubMed

Tomich, Georgia Miranda; França, Danielle Corrêa; Diniz, Marco Túlio Costa; Britto, Raquel Rodrigues; Sampaio, Rosana Ferreira; Parreira, Verônica Franco

2010-01-01

To evaluate breathing pattern and thoracoabdominal motion during breathing exercises. Twenty-four patients with class II or III obesity (18 women; 6 men) were studied on the second postoperative day after gastroplasty. The mean age was 37 +/- 11 years, and the mean BMI was 44 +/- 3 kg/m(2). Diaphragmatic breathing, incentive spirometry with a flow-oriented device and incentive spirometry with a volume-oriented device were performed in random order. Respiratory inductive plethysmography was used in order to measure respiratory variables and thoracoabdominal motion. Comparisons among the three exercises showed significant differences: tidal volume was higher during incentive spirometry (with the flow-oriented device or with the volume-oriented device) than during diaphragmatic breathing; the respiratory rate was lower during incentive spirometry with the volume-oriented device than during incentive spirometry with the flow-oriented device; and minute ventilation was higher during incentive spirometry (with the flow-oriented device or with the volume-oriented device) than during diaphragmatic breathing. Rib cage motion did not vary during breathing exercises, although there was an increase in thoracoabdominal asynchrony, especially during incentive spirometry with the flow-oriented device. Among the breathing exercises evaluated, incentive spirometry with the volume-oriented device provided the best results, because it allowed slower, deeper inhalation.

Comparison of electrical capacitance tomography and gamma densitometer measurement in viscous oil-gas flows

DOE Office of Scientific and Technical Information (OSTI.GOV)

Archibong Eso, A.; Zhao, Yabin; Yeung, Hoi

2014-04-11

Multiphase flow is a common occurrence in industries such as nuclear, process, oil and gas, food and chemical. A prior knowledge of its features and characteristics is essential in the design, control and management of such processes due to its complex nature. Electrical Capacitance Tomography (ECT) and Gamma Densitometer (Gamma) are two promising approaches for multiphase visualization and characterization in process industries. In two phase oil and gas flow, ECT and Gamma are used in multiphase flow monitoring techniques due to their inherent simplicity, robustness, and an ability to withstand wide range of operational temperatures and pressures. High viscous oilmore » (viscosity > 100 cP) is of interest because of its huge reserves, technological advances in its production and unlike conventional oil (oil viscosity < 100 cP) and gas flows where ECT and Gamma have been previously used, high viscous oil and gas flows comes with certain associated concerns which include; increased entrainment of gas bubbles dispersed in oil, shorter and more frequent slugs as well as oil film coatings on the walls of flowing conduits. This study aims to determine the suitability of both devices in the visualization and characterization of high-viscous oil and gas flow. Static tests are performed with both devices and liquid holdup measurements are obtained. Dynamic experiments were also conducted in a 1 and 3 inch facility at Cranfield University with a range of nominal viscosities (1000, 3000 and 7500 cP). Plug, slug and wavy annular flow patterns were identified by means of Probability Mass Function and time series analysis of the data acquired from Gamma and ECT devices with high speed camera used to validate the results. Measured Liquid holdups for both devices were also compared.« less

Comparison of electrical capacitance tomography & gamma densitometer measurement in viscous oil-gas flows

NASA Astrophysics Data System (ADS)

Archibong Eso, A.; Zhao, Yabin; Yeung, Hoi

2014-04-01

Multiphase flow is a common occurrence in industries such as nuclear, process, oil & gas, food and chemical. A prior knowledge of its features and characteristics is essential in the design, control and management of such processes due to its complex nature. Electrical Capacitance Tomography (ECT) and Gamma Densitometer (Gamma) are two promising approaches for multiphase visualization and characterization in process industries. In two phase oil & gas flow, ECT and Gamma are used in multiphase flow monitoring techniques due to their inherent simplicity, robustness, and an ability to withstand wide range of operational temperatures and pressures. High viscous oil (viscosity > 100 cP) is of interest because of its huge reserves, technological advances in its production and unlike conventional oil (oil viscosity < 100 cP) and gas flows where ECT and Gamma have been previously used, high viscous oil and gas flows comes with certain associated concerns which include; increased entrainment of gas bubbles dispersed in oil, shorter and more frequent slugs as well as oil film coatings on the walls of flowing conduits. This study aims to determine the suitability of both devices in the visualization and characterization of high-viscous oil and gas flow. Static tests are performed with both devices and liquid holdup measurements are obtained. Dynamic experiments were also conducted in a 1 & 3 inch facility at Cranfield University with a range of nominal viscosities (1000, 3000 & 7500 cP). Plug, slug and wavy annular flow patterns were identified by means of Probability Mass Function and time series analysis of the data acquired from Gamma and ECT devices with high speed camera used to validate the results. Measured Liquid holdups for both devices were also compared.

Stagnation point flow of wormlike micellar solutions in a microfluidic cross-slot device: effects of surfactant concentration and ionic environment.

PubMed

Haward, Simon J; McKinley, Gareth H

2012-03-01

We employ the techniques of microparticle image velocimetry and full-field birefringence microscopy combined with mechanical measurements of the pressure drop to perform a detailed characterization of the extensional rheology and elastic flow instabilities observed for a range of wormlike micellar solutions flowing through a microfluidic cross-slot device. As the flow rate through the device is increased, the flow first bifurcates from a steady symmetric to a steady asymmetric configuration characterized by a birefringent strand of highly aligned micellar chains oriented along the shear-free centerline of the flow field. At higher flow rates the flow becomes three dimensional and time dependent and is characterized by aperiodic spatiotemporal fluctuations of the birefringent strand. The extensional properties and critical conditions for the onset of flow instabilities in the fluids are highly dependent on the fluid formulation (surfactant concentration and ionic strength) and the resulting changes in the linear viscoelasticity and nonlinear shear rheology of the fluids. By combining the measurements of critical conditions for the flow transitions with the viscometric material properties and the degree of shear-thinning characterizing each test fluid, it is possible to construct a stability diagram for viscoelastic flow of complex fluids in the cross-slot geometry.

Extensional flow of hyaluronic acid solutions in an optimized microfluidic cross-slot device.

PubMed

Haward, S J; Jaishankar, A; Oliveira, M S N; Alves, M A; McKinley, G H

2013-07-01

We utilize a recently developed microfluidic device, the Optimized Shape Cross-slot Extensional Rheometer (OSCER), to study the elongational flow behavior and rheological properties of hyaluronic acid (HA) solutions representative of the synovial fluid (SF) found in the knee joint. The OSCER geometry is a stagnation point device that imposes a planar extensional flow with a homogenous extension rate over a significant length of the inlet and outlet channel axes. Due to the compressive nature of the flow generated along the inlet channels, and the planar elongational flow along the outlet channels, the flow field in the OSCER device can also be considered as representative of the flow field that arises between compressing articular cartilage layers of the knee joints during running or jumping movements. Full-field birefringence microscopy measurements demonstrate a high degree of localized macromolecular orientation along streamlines passing close to the stagnation point of the OSCER device, while micro-particle image velocimetry is used to quantify the flow kinematics. The stress-optical rule is used to assess the local extensional viscosity in the elongating fluid elements as a function of the measured deformation rate. The large limiting values of the dimensionless Trouton ratio, Tr ∼ O(50), demonstrate that these fluids are highly extensional-thickening, providing a clear mechanism for the load-dampening properties of SF. The results also indicate the potential for utilizing the OSCER in screening of physiological SF samples, which will lead to improved understanding of, and therapies for, disease progression in arthritis sufferers.

21 CFR 870.2780 - Hydraulic, pneumatic, or photoelectric plethysmographs.

Code of Federal Regulations, 2012 CFR

2012-04-01

... HUMAN SERVICES (CONTINUED) MEDICAL DEVICES CARDIOVASCULAR DEVICES Cardiovascular Monitoring Devices..., pneumatic, or photoelectric plethysmograph is a device used to estimate blood flow in a region of the body using hydraulic, pneumatic, or photoelectric measurement techniques. (b) Classification. Class II...

21 CFR 870.2780 - Hydraulic, pneumatic, or photoelectric plethysmographs.

Code of Federal Regulations, 2014 CFR

2014-04-01

... HUMAN SERVICES (CONTINUED) MEDICAL DEVICES CARDIOVASCULAR DEVICES Cardiovascular Monitoring Devices..., pneumatic, or photoelectric plethysmograph is a device used to estimate blood flow in a region of the body using hydraulic, pneumatic, or photoelectric measurement techniques. (b) Classification. Class II...

21 CFR 870.2780 - Hydraulic, pneumatic, or photoelectric plethysmographs.

Code of Federal Regulations, 2013 CFR

2013-04-01

... HUMAN SERVICES (CONTINUED) MEDICAL DEVICES CARDIOVASCULAR DEVICES Cardiovascular Monitoring Devices..., pneumatic, or photoelectric plethysmograph is a device used to estimate blood flow in a region of the body using hydraulic, pneumatic, or photoelectric measurement techniques. (b) Classification. Class II...

Cross-correlation-based transverse flow measurements using optical resolution photoacoustic microscopy with a digital micromirror device

PubMed Central

Liang, Jinyang; Zhou, Yong; Maslov, Konstantin I.

2013-01-01

Abstract. A cross-correlation-based method is proposed to quantitatively measure transverse flow velocity using optical resolution photoacoustic (PA) microscopy enhanced with a digital micromirror device (DMD). The DMD is used to alternately deliver two spatially separated laser beams to the target. Through cross-correlation between the slow-time PA profiles measured from the two beams, the speed and direction of transverse flow are simultaneously derived from the magnitude and sign of the time shift, respectively. Transverse flows in the range of 0.50 to 6.84  mm/s are accurately measured using an aqueous suspension of 10-μm-diameter microspheres, and the root-mean-squared measurement accuracy is quantified to be 0.22  mm/s. The flow measurements are independent of the particle size for flows in the velocity range of 0.55 to 6.49  mm/s, which was demonstrated experimentally using three different sizes of microspheres (diameters: 3, 6, and 10 μm). The measured flow velocity follows an expected parabolic distribution along the depth direction perpendicular to the flow. Both maximum and minimum measurable velocities are investigated for varied distances between the two beams and varied total time for one measurement. This technique shows an accuracy of 0.35  mm/s at 0.3-mm depth in scattering chicken breast, making it promising for measuring flow in biological tissue. PMID:24002191

The effect of vacuum devices on penile hemodynamics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Katz, P.G.; Haden, H.T.; Mulligan, T.

1990-01-01

External vacuum devices are being used increasingly for the management of erectile dysfunction. There is limited information regarding the effect of vacuum devices on penile blood flow and potential for ischemic penile injury. The penile xenon washout rate was measured before and after application of 2 vacuum systems in 15 subjects. Compared to flaccid state measurements the xenon washout rate did not change significantly with the Synergist Erection System but it was significantly reduced with the Osbon ErecAid System. However, the degree and duration of decrease in penile blood flow that may result in ischemic changes are unknown.

Phenomenological methodology for assessing the influence of flow conditions on the acoustic response of exhaust aftertreatment systems

NASA Astrophysics Data System (ADS)

Torregrosa, A. J.; Arnau, F. J.; Piqueras, P.; Sanchis, E. J.; Tartoussi, H.

2017-05-01

The increasing limits of standards on aerosol and gaseous emissions from internal combustion engines have led to the progressive inclusion of different exhaust aftertreatment systems (EATS) as a part of the powertrain. Regulated emissions are generally abated making use of devices based on monolithic structures with different chemical functions. As a side effect, wave transmission across the device is affected and so is the boundary at the exhaust line inlet, so that the design of the latter is in turn affected. While some models are available for the prediction of these effects, the geometrical complexity of many devices makes still necessary in many cases to rely on experimental measurements, which cannot cover all the diversity of flow conditions under which these devices operate. To overcome this limitation, a phenomenological methodology is proposed in this work that allows for the sound extrapolation of experimental results to flow conditions different from those used in the measurements. The transfer matrix is obtained from tests in an impulse rig for different excitation amplitudes and mean flows. The experimental coefficients of the transmission matrix of the device are fitted to Fourier series. It allows treating the influence of the flow conditions on the acoustic response, which is manifested on changes in the characteristic periods, separately from the specific properties of every device. In order to provide predictive capabilities to the method, the Fourier series approach is coupled to a gas dynamics model able to account for the sensitivity of propagation velocity to variations in the flow conditions.

A new device for intraoperative renal blood flow measurement during open-heart surgery: an experimental study and the clinical pilot study.

PubMed

Tirilomis, Theodor; Popov, Aron F; Hanekop, Gunnar G; Braeuer, Anselm; Quintel, Michael; Schoendube, Friedrich A; Friedrich, Martin G

2013-10-01

Renal blood flow (RBF) may vary during cardiopulmonary bypass and low flow may cause insufficient blood supply of the kidney triggering renal failure postoperatively. Still, a valid intraoperative method of continuous RBF measurement is not available. A new catheter combining thermodilution and intravascular Doppler was developed, first calibrated in an in vitro model, and the catheter specific constant was determined. Then, application of the device was evaluated in a pilot study in an adult cardiovascular population. The data of the clinical pilot study revealed high correlation between the flow velocities detected by intravascular Doppler and the RBF measured by thermodilution (Pearson's correlation range: 0.78 to 0.97). In conclusion, the RBF can be measured excellently in real time using the new catheter, even under cardiopulmonary bypass. © 2013 Wiley Periodicals, Inc. and International Center for Artificial Organs and Transplantation.

Wastewater Sampling Methodologies and Flow Measurement Techniques.

ERIC Educational Resources Information Center

Harris, Daniel J.; Keffer, William J.

This document provides a ready source of information about water/wastewater sampling activities using various commercial sampling and flow measurement devices. The report consolidates the findings and summarizes the activities, experiences, sampling methods, and field measurement techniques conducted by the Environmental Protection Agency (EPA),…

Laser induced fluorescence measurements of ion velocity and temperature of drift turbulence driven sheared plasma flow in a linear helicon plasma device

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chakraborty Thakur, S.; Fedorczak, N.; Manz, P.

2012-08-15

Using laser induced fluorescence (LIF), radial profiles of azimuthal ion fluid velocity and ion temperature are measured in the controlled shear de-correlation experiment (CSDX) linear helicon plasma device. Ion velocities and temperatures are derived from the measured Doppler broadened velocity distribution functions of argon ions. The LIF system employs a portable, high power (>300 mW), narrowband ({approx}1 MHz) tunable diode laser-based system operating at 668.614 nm. Previous studies in CSDX have shown the existence of a radially sheared azimuthal flow as measured with time delay estimation methods and Mach probes. Here, we report the first LIF measurements of sheared plasmamore » fluid flow in CSDX. Above a critical magnetic field, the ion fluid flow profile evolves from radially uniform to peaked on axis with a distinct reversed flow region at the boundary, indicating the development of a sheared azimuthal flow. Simultaneously, the ion temperature also evolves from a radially uniform profile to a profile with a gradient. Measurements in turbulent and coherent drift wave mode dominated plasmas are compared.« less

Compact, multi-exposure speckle contrast optical spectroscopy (SCOS) device for measuring deep tissue blood flow

PubMed Central

Dragojević, Tanja; Hollmann, Joseph L.; Tamborini, Davide; Portaluppi, Davide; Buttafava, Mauro; Culver, Joseph P.; Villa, Federica; Durduran, Turgut

2017-01-01

Speckle contrast optical spectroscopy (SCOS) measures absolute blood flow in deep tissue, by taking advantage of multi-distance (previously reported in the literature) or multi-exposure (reported here) approach. This method promises to use inexpensive detectors to obtain good signal-to-noise ratio, but it has not yet been implemented in a suitable manner for a mass production. Here we present a new, compact, low power consumption, 32 by 2 single photon avalanche diode (SPAD) array that has no readout noise, low dead time and has high sensitivity in low light conditions, such as in vivo measurements. To demonstrate the capability to measure blood flow in deep tissue, healthy volunteers were measured, showing no significant differences from the diffuse correlation spectroscopy. In the future, this array can be miniaturized to a low-cost, robust, battery operated wireless device paving the way for measuring blood flow in a wide-range of applications from sport injury recovery and training to, on-field concussion detection to wearables. PMID:29359106

RADIATION MEASURING DEVICES

DOEpatents

Bouricius, G.M.B.; Rusch, G.K.

1960-03-22

A radiation-measuring device is described having an a-c output. The apparatus has a high-energy particle source responsive to radiation flux disposed within a housing having a pair of collector plates. A potential gradient between the source and collector plates causes ions to flow to the plates. By means of electrostatic or magnetic deflection elements connected to an alternating potential, the ions are caused to flow alternately to each of the collector plates causing an a-c signal thereon.

Fluid-flow pressure measurements and thermo-fluid characterization of a single loop two-phase passive heat transfer device

NASA Astrophysics Data System (ADS)

Ilinca, A.; Mangini, D.; Mameli, M.; Fioriti, D.; Filippeschi, S.; Araneo, L.; Roth, N.; Marengo, M.

2017-11-01

A Novel Single Loop Pulsating Heat Pipe (SLPHP), with an inner diameter of 2 mm, filled up with two working fluids (Ethanol and FC-72, Filling Ratio of 60%), is tested in Bottom Heated mode varying the heating power and the orientation. The static confinement diameter for Ethanol and FC-72, respectively 3.4 mm and 1.7mm, is above and slightly under the inner diameter of the tube. This is important for a better understanding of the working principle of the device very close to the limit between the Loop Thermosyphon and Pulsating Heat Pipe working modes. With respect to previous SLPHP experiments found in the literature, such device is designed with two transparent inserts mounted between the evaporator and the condenser allowing direct fluid flow visualization. Two highly accurate pressure transducers permit local pressure measurements just at the edges of one of the transparent inserts. Additionally, three heating elements are controlled independently, so as to vary the heating distribution at the evaporator. It is found that peculiar heating distributions promote the slug/plug flow motion in a preferential direction, increasing the device overall performance. Pressure measurements point out that the pressure drop between the evaporator and the condenser are related to the flow pattern. Furthermore, at high heat inputs, the flow regimes recorded for the two fluids are very similar, stressing that, when the dynamic effects start to play a major role in the system, the device classification between Loop Thermosyphon and Pulsating Heat Pipe is not that sharp anymore.

Identifying the best locations to install flow control devices in sewer networks to enable in-sewer storage

NASA Astrophysics Data System (ADS)

Leitão, J. P.; Carbajal, J. P.; Rieckermann, J.; Simões, N. E.; Sá Marques, A.; de Sousa, L. M.

2018-01-01

The activation of available in-sewer storage volume has been suggested as a low-cost flood and combined sewer overflow mitigation measure. However, it is currently unknown what the attributes for suitable objective functions to identify the best location for flow control devices are and the impact of those attributes on the results. In this study, we present a novel location model and efficient algorithm to identify the best location(s) to install flow limiters. The model is a screening tool that does not require hydraulic simulations but rather considers steady state instead of simplistic static flow conditions. It also maximises in-sewer storage according to different reward functions that also considers the potential impact of flow control device failure. We demonstrate its usefulness on two real sewer networks, for which an in-sewer storage potential of approximately 2,000 m3 and 500 m3 was estimated with five flow control devices installed.

Measurement of protection factor of respiratory protective devices toward nanoparticles.

PubMed

Brochot, C; Michielsen, N; Chazelet, S; Thomas, D

2012-07-01

The use of nanoparticles in industry has increased spectacularly over the past few years. Additionally, nanoscale particles seem to be the cause of new professional exposure situations. Due to their size, these particles may build up within the respiratory tract and may even reach the nervous system via the nasal passages; for this reason, it is generally recommended to wear respiratory protective devices (RPDs) in situations where collective protection is impossible to implement or inadequate. Here, we present the test bench ETNA designed to study the efficiency of RPDs in the presence of nanoparticles. The results of the efficiency measurement of two RPDs for two positions (sealed and unsealed) on a Sheffield head, for two inhalation configurations (constant flow and cyclic flow), and for two different particle size distributions of NaCl aerosol (one centered on 13 nm and the other on 59 nm) are presented below. The measurements indicate that when the leaks are negligible at the interface mask/head, the efficiency of RPD is greater for nanoparticles. For major leaks, the device's protection factor changes independently of the size of the particles. Furthermore, no trends with respect to the effect of the respiration type (constant-flow and cyclic-flow tests) have been shown on the device's protection factor.

Microfluidic method for measuring viscosity using images from smartphone

NASA Astrophysics Data System (ADS)

Kim, Sooyeong; Kim, Kyung Chun; Yeom, Eunseop

2018-05-01

The viscosity of a fluid is the most important characteristic in fluid rheology. Many microfluidic devices have been proposed for easily measuring the fluid viscosity of small samples. A hybrid system consisting of a smartphone and microfluidic device can offer a mobile laboratory for performing a wide range of detection and analysis functions related to healthcare. In this study, a new mobile sensing method based on a microfluidic device was proposed for fluid viscosity measurements. By separately delivering sample and reference fluids into the two inlets of a Y-shaped microfluidic device, an interfacial line is induced at downstream of the device. Because the interfacial width (W) between the sample and reference fluid flows was determined by their pressure ratio, the viscosity (μ) of the sample could be estimated by measuring the interfacial width. To distinguish the interfacial width of a sample, optical images of the flows at downstream of the Y-shaped microfluidic device were acquired using a smartphone. To check the measurement accuracy of the proposed method, the viscosities of glycerol mixtures were compared with those measured by a conventional viscometer. The proposed technique was applied to monitor the variations in blood and oil samples depending on storage or rancidity. We expect that this mobile sensing method based on a microfluidic device could be utilized as a viscometer with significant advantages in terms of mobility, ease-of-operation, and data management.

40 CFR 63.4168 - What are the requirements for continuous parameter monitoring system installation, operation, and...

Code of Federal Regulations, 2014 CFR

2014-07-01

... add-on control device, you must monitor the total regeneration desorbing gas (e.g., steam or nitrogen) mass flow for each regeneration cycle, the carbon bed temperature after each regeneration and cooling... regeneration desorbing gas mass flow monitor must be an integrating device having a measurement sensitivity of...

Improvement in Rayleigh Scattering Measurement Accuracy

NASA Technical Reports Server (NTRS)

Fagan, Amy F.; Clem, Michelle M.; Elam, Kristie A.

2012-01-01

Spectroscopic Rayleigh scattering is an established flow diagnostic that has the ability to provide simultaneous velocity, density, and temperature measurements. The Fabry-Perot interferometer or etalon is a commonly employed instrument for resolving the spectrum of molecular Rayleigh scattered light for the purpose of evaluating these flow properties. This paper investigates the use of an acousto-optic frequency shifting device to improve measurement accuracy in Rayleigh scattering experiments at the NASA Glenn Research Center. The frequency shifting device is used as a means of shifting the incident or reference laser frequency by 1100 MHz to avoid overlap of the Rayleigh and reference signal peaks in the interference pattern used to obtain the velocity, density, and temperature measurements, and also to calibrate the free spectral range of the Fabry-Perot etalon. The measurement accuracy improvement is evaluated by comparison of Rayleigh scattering measurements acquired with and without shifting of the reference signal frequency in a 10 mm diameter subsonic nozzle flow.

40 CFR 63.11646 - What are my compliance requirements?

Code of Federal Regulations, 2012 CFR

2012-07-01

... with Method 29 must collect a minimum sample volume of 0.85 dry standard cubic meters (30 dry standard... weight measurement device, mass flow meter, or densitometer and volumetric flow meter to measure ore...) Measure the weight of concentrate (produced by electrowinning, Merrill Crowe process, gravity feed, or...

40 CFR 63.11646 - What are my compliance requirements?

Code of Federal Regulations, 2014 CFR

2014-07-01

... with Method 29 must collect a minimum sample volume of 0.85 dry standard cubic meters (30 dry standard... weight measurement device, mass flow meter, or densitometer and volumetric flow meter to measure ore...) Measure the weight of concentrate (produced by electrowinning, Merrill Crowe process, gravity feed, or...

40 CFR 63.11646 - What are my compliance requirements?

Code of Federal Regulations, 2011 CFR

2011-07-01

... with Method 29 must collect a minimum sample volume of 0.85 dry standard cubic meters (30 dry standard... weight measurement device, mass flow meter, or densitometer and volumetric flow meter to measure ore...) Measure the weight of concentrate (produced by electrowinning, Merrill Crowe process, gravity feed, or...

40 CFR 63.11646 - What are my compliance requirements?

Code of Federal Regulations, 2013 CFR

2013-07-01

... with Method 29 must collect a minimum sample volume of 0.85 dry standard cubic meters (30 dry standard... weight measurement device, mass flow meter, or densitometer and volumetric flow meter to measure ore...) Measure the weight of concentrate (produced by electrowinning, Merrill Crowe process, gravity feed, or...

Fluidic nanotubes and devices

DOEpatents

Yang, Peidong [Berkeley, CA; He, Rongrui [El Cerrito, CA; Goldberger, Joshua [Berkeley, CA; Fan, Rong [El Cerrito, CA; Wu, Yiying [Albany, CA; Li, Deyu [Albany, CA; Majumdar, Arun [Orinda, CA

2008-04-08

Fluidic nanotube devices are described in which a hydrophilic, non-carbon nanotube, has its ends fluidly coupled to reservoirs. Source and drain contacts are connected to opposing ends of the nanotube, or within each reservoir near the opening of the nanotube. The passage of molecular species can be sensed by measuring current flow (source-drain, ionic, or combination). The tube interior can be functionalized by joining binding molecules so that different molecular species can be sensed by detecting current changes. The nanotube may be a semiconductor, wherein a tubular transistor is formed. A gate electrode can be attached between source and drain to control current flow and ionic flow. By way of example an electrophoretic array embodiment is described, integrating MEMs switches. A variety of applications are described, such as: nanopores, nanocapillary devices, nanoelectrophoretic, DNA sequence detectors, immunosensors, thermoelectric devices, photonic devices, nanoscale fluidic bioseparators, imaging devices, and so forth.

Fluidic nanotubes and devices

DOEpatents

Yang, Peidong; He, Rongrui; Goldberger, Joshua; Fan, Rong; Wu, Yiying; Li, Deyu; Majumdar, Arun

2010-01-10

Fluidic nanotube devices are described in which a hydrophilic, non-carbon nanotube, has its ends fluidly coupled to reservoirs. Source and drain contacts are connected to opposing ends of the nanotube, or within each reservoir near the opening of the nanotube. The passage of molecular species can be sensed by measuring current flow (source-drain, ionic, or combination). The tube interior can be functionalized by joining binding molecules so that different molecular species can be sensed by detecting current changes. The nanotube may be a semiconductor, wherein a tubular transistor is formed. A gate electrode can be attached between source and drain to control current flow and ionic flow. By way of example an electrophoretic array embodiment is described, integrating MEMs switches. A variety of applications are described, such as: nanopores, nanocapillary devices, nanoelectrophoretic, DNA sequence detectors, immunosensors, thermoelectric devices, photonic devices, nanoscale fluidic bioseparators, imaging devices, and so forth.

Hollow-Fiber Cartridges: Model Systems for Virus Removal from Blood

NASA Astrophysics Data System (ADS)

Jacobitz, Frank; Menon, Jeevan

2005-11-01

Aethlon Medical is developing a hollow-fiber hemodialysis device designed to remove viruses and toxins from blood. Possible target viruses include HIV and pox-viruses. The filter could reduce virus and viral toxin concentration in the patient's blood, delaying illness so the patient's immune system can fight off the virus. In order to optimize the design of such a filter, the fluid mechanics of the device is both modeled analytically and investigated experimentally. The flow configuration of the proposed device is that of Starling flow. Polysulfone hollow-fiber dialysis cartridges were used. The cartridges are charged with water as a model fluid for blood and fluorescent latex beads are used in the experiments as a model for viruses. In the experiments, properties of the flow through the cartridge are determined through pressure and volume flow rate measurements of water. The removal of latex beads, which are captured in the porous walls of the fibers, was measured spectrophotometrically. Experimentally derived coefficients derived from these experiments are used in the analytical model of the flow and removal predictions from the model are compared to those obtained from the experiments.

3D modeling and characterization of a calorimetric flow rate sensor for sweat rate sensing applications

NASA Astrophysics Data System (ADS)

Iftekhar, Ahmed Tashfin; Ho, Jenny Che-Ting; Mellinger, Axel; Kaya, Tolga

2017-03-01

Sweat-based physiological monitoring has been intensively explored in the last decade with the hopes of developing real-time hydration monitoring devices. Although the content of sweat (electrolytes, lactate, urea, etc.) provides significant information about the physiology, it is also very important to know the rate of sweat at the time of sweat content measurements because the sweat rate is known to alter the concentrations of sweat compounds. We developed a calorimetric based flow rate sensor using PolydimethylSiloxane that is suitable for sweat rate applications. Our simple approach on using temperature-based flow rate detection can easily be adapted to multiple sweat collection and analysis devices. Moreover, we have developed a 3D finite element analysis model of the device using COMSOL Multiphysics™ and verified the flow rate measurements. The experiment investigated flow rate values from 0.3 μl/min up to 2.1 ml/min, which covers the human sweat rate range (0.5 μl/min-10 μl/min). The 3D model simulations and analytical model calculations covered an even wider range in order to understand the main physical mechanisms of the device. With a verified 3D model, different environmental heat conditions could be further studied to shed light on the physiology of the sweat rate.

Effect of geometry and scale for axial and radial flow membrane chromatography-Experimental study of bovin serum albumin adsorption.

PubMed

Teepakorn, Chalore; Fiaty, Koffi; Charcosset, Catherine

2015-07-17

During the last 10 years, membrane chromatography (MC) has been increasingly reported for biomolecule purification at both small and large scales. Although, several axial and radial flow MC devices are commercialized, the effect of the device dimensions on the adsorption performance has not been fully investigated. In this study, axial and radial flow anion ion-exchange MC devices were used for bovine serum albumin (BSA) adsorption. For both axial and radial flow, three devices at different scales were compared, two having similar diameter and two similar bed height. The pressure drop and the flow distribution using acetone as a non-binding solute were measured, as well as BSA breakthrough curves at different flow rates and BSA loading concentrations. For all devices, it was observed that the flow rate had no effect on the breakthrough curve, which confirms the advantage of MC to be used at high flow rates. In addition, the BSA binding capacity increased with increasing BSA concentration, which suggests that it could be preferable to work with concentrated solutions rather than with very dilute solutions, when using buffer at high phosphate concentration. For both axial and radial flow, the bed height had a negative impact on the binding capacity, as the lowest binding capacities per membrane volume were obtained with the devices having the highest bed height. Radial flow MC has potential at large-scale applications, as a short bed thickness can be combined with a large inlet surface area. Copyright © 2015 Elsevier B.V. All rights reserved.

Device accurately measures and records low gas-flow rates

NASA Technical Reports Server (NTRS)

Branum, L. W.

1966-01-01

Free-floating piston in a vertical column accurately measures and records low gas-flow rates. The system may be calibrated, using an adjustable flow-rate gas supply, a low pressure gage, and a sequence recorder. From the calibration rates, a nomograph may be made for easy reduction. Temperature correction may be added for further accuracy.

Device for accurately measuring mass flow of gases

DOEpatents

Hylton, J.O.; Remenyik, C.J.

1994-08-09

A device for measuring mass flow of gases which utilizes a substantially buoyant pressure vessel suspended within a fluid/liquid in an enclosure is disclosed. The pressure vessel is connected to a weighing device for continuously determining weight change of the vessel as a function of the amount of gas within the pressure vessel. In the preferred embodiment, this pressure vessel is formed from inner and outer right circular cylindrical hulls, with a volume between the hulls being vented to the atmosphere external the enclosure. The fluid/liquid, normally in the form of water typically with an added detergent, is contained within an enclosure with the fluid/liquid being at a level such that the pressure vessel is suspended beneath this level but above a bottom of the enclosure. The buoyant pressure vessel can be interconnected with selected valves to an auxiliary pressure vessel so that initial flow can be established to or from the auxiliary pressure vessel prior to flow to or from the buoyant pressure vessel. 5 figs.

Device for accurately measuring mass flow of gases

DOEpatents

Hylton, James O.; Remenyik, Carl J.

1994-01-01

A device for measuring mass flow of gases which utilizes a substantially buoyant pressure vessel suspended within a fluid/liquid in an enclosure. The pressure vessel is connected to a weighing device for continuously determining weight change of the vessel as a function of the amount of gas within the pressure vessel. In the preferred embodiment, this pressure vessel is formed from inner and outer right circular cylindrical hulls, with a volume between the hulls being vented to the atmosphere external the enclosure. The fluid/liquid, normally in the form of water typically with an added detergent, is contained within an enclosure with the fluid/liquid being at a level such that the pressure vessel is suspended beneath this level but above a bottom of the enclosure. The buoyant pressure vessel can be interconnected with selected valves to an auxiliary pressure vessel so that initial flow can be established to or from the auxiliary pressure vessel prior to flow to or from the buoyant pressure vessel.

Composition Pulse Time-Of-Flight Mass Flow Sensor

DOEpatents

Mosier, Bruce P.; Crocker, Robert W.; Harnett, Cindy K. l

2004-01-13

A device for measuring fluid flow rates over a wide range of flow rates (<1 nL/min to >10 .mu.L/min) and at pressures at least as great as 10,000 psi. The invention is particularly adapted for use in microfluidic systems. The device operates by producing compositional variations in the fluid, or pulses, that are subsequently detected downstream from the point of creation to derive a flow rate. Each pulse, comprising a small fluid volume, whose composition is different from the mean composition of the fluid, can be created by electrochemical means, such as by electrolysis of a solvent, electrolysis of a dissolved species, or electrodialysis of a dissolved ionic species. Measurements of the conductivity of the fluid can be used to detect the arrival time of the pulses, from which the fluid flow rate can be determined

A gravimetric technique for evaluating flow continuity from two infusion devices.

PubMed

Leff, R D; True, W R; Roberts, R J

1987-06-01

A computerized gravimetric technique for examining the flow continuity from infusion devices was developed, and two infusion devices with different mechanisms of pump operation were evaluated to illustrate this technique. A BASIC program that records serial weight measurements and calculates weight change from previous determinations was written for and interfaced with a gravimetric balance and IBM PC. A plot of effused weight (normalized weight change that reflects the difference between desired timed-sample interval and actual time) versus time (desired timed-sample interval) was constructed. The gravimetric technique was evaluated using both a peristaltic-type and a piston-type infusion pump. Intravenous solution (5% dextrose and 0.9% sodium chloride) was effused at 10 mL/hr and collected in a beaker. Weights were measured at 10-second intervals over a two-hour infusion period, and the weights of the effused solution were plotted versus time. Flow continuity differed between the two infusion devices. Actual effused weight decreased to 0.007 g/10 sec during the refill cycle of the piston-type pump; the mean (+/- S.D.) effused weight was 0.029 +/- 0.002 g/10 sec. The desired effusion rate was 0.028 g/10 sec. The peristaltic pump had greater flow continuity, with a mean effusion weight of 0.028 +/- 0.003 g/10 sec. The gravimetric technique described in this report can be used to quantitatively depict the effusion profiles of infusion devices. Further studies are needed to identify the degree of flow continuity that is clinically acceptable for infusion devices.

Corpuls cpr resuscitation device generates superior emulated flows and pressures than LUCAS II in a mechanical thorax model.

PubMed

Eichhorn, S; Mendoza Garcia, A; Polski, M; Spindler, J; Stroh, A; Heller, M; Lange, R; Krane, M

2017-06-01

The provision of sufficient chest compression is among the most important factors influencing patient survival during cardiopulmonary resuscitation (CPR). One approach to optimize the quality of chest compressions is to use mechanical-resuscitation devices. The aim of this study was to compare a new device for chest compression (corpuls cpr) with an established device (LUCAS II). We used a mechanical thorax model consisting of a chest with variable stiffness and an integrated heart chamber which generated blood flow dependent on the compression depth and waveform. The method of blood-flow generation could be changed between direct cardiac-compression mode and thoracic-pump mode. Different chest-stiffness settings and compression modes were tested to generate various blood-flow profiles. Additionally, an endurance test at high stiffness was performed to measure overall performance and compression consistency. Both resuscitation machines were able to compress the model thorax with a frequency of 100/min and a depth of 5 cm, independent of the chosen chest stiffness. Both devices passed the endurance test without difficulty. The corpuls cpr device was able to generate about 10-40% more blood flow than the LUCAS II device, depending on the model settings. In most scenarios, the corpuls cpr device also generated a higher blood pressure than the LUCAS II. The peak compression forces during CPR were about 30% higher using the corpuls cpr device than with the LUCAS II. In this study, the corpuls cpr device had improved blood flow and pressure outcomes than the LUCAS II device. Further examination in an animal model is required to prove the findings of this preliminary study.

Control of unsteady separated flow associated with the dynamic stall of airfoils

NASA Technical Reports Server (NTRS)

Wilder, Michael C.

1992-01-01

The two principal objectives of this research were to achieve an improved understanding of the mechanisms involved in the onset and development of dynamic stall under compressible flow conditions, and to investigate the feasibility of employing adaptive airfoil geometry as an active flow control device in the dynamic stall engine. Presented here are the results of a quantitative (PDI) study of the compressibility effects on dynamic stall over the transiently pitching airfoil, as well as a discussion of a preliminary technique developed to measure the deformation produced by the adaptive geometry control device, and bench test results obtained using an airfoil equipped with the device.

Flowmeter for Clear and Translucent Fluids

NASA Technical Reports Server (NTRS)

White, P. R.

1985-01-01

Transducer with only three moving parts senses flow of clear or translucent fluid. Displacement of diaphragm by force of flow detected electrooptically and displayed by panel meter or other device. Transducer used to measure flow of gasoline to automobile engine.

Measurements of ion temperature and flow of pulsed plasmas produced by a magnetized coaxial plasma gun device using an ion Doppler spectrometer

NASA Astrophysics Data System (ADS)

Kitagawa, Y.; Sakuma, I.; Iwamoto, D.; Kikuchi, Y.; Fukumoto, N.; Nagata, M.

2012-10-01

It is important to know surface damage characteristics of plasma-facing component materials during transient heat and particle loads such as type I ELMs. A magnetized coaxial plasma gun (MCPG) device has been used as transient heat and particle source in ELM simulation experiments. Characteristics of pulsed plasmas produced by the MCPG device play an important role for the plasma material interaction. In this study, ion temperature and flow velocity of pulsed He plasmas were measured by an ion Doppler spectrometer (IDS). The IDS system consists of a light collection system including optical fibers, 1m-spectrometer and a 16 channel photomultiplier tube (PMT) detector. The IDS system measures the width and Doppler shift of HeII (468.58 nm) emission line with the time resolution of 1 μs. The Doppler broadened and shifted spectra were measured with 45 and 135 degree angles with respect to the plasmoid traveling direction. The observed emission line profile was represented by sum of two Gaussian components to determine the temperature and flow velocity. The minor component at around the wavelength of zero-velocity was produced by the stationary plasma. As the results, the ion velocity and temperature were 68 km/s and 19 eV, respectively. Thus, the He ion flow energy is 97 eV. The observed flow velocity agrees with that measured by a time of flight technique.

An evaluation of 2 new devices for nasal high-flow gas therapy.

PubMed

Waugh, Jonathan B; Granger, Wesley M

2004-08-01

The traditional nasal cannula with bubble humidifier is limited to a maximum flow of 6 L/min to minimize the risk of complications. We conducted a bench study of 2 new Food and Drug Administration-approved nasal cannula/humidifier products designed to deliver at flows> 6 L/min. Using a digital psychrometer we measured the relative humidity and temperature of delivered gas from each device, at 5 L/min increments over the specified functional high-flow range. The Salter Labs unit achieved 72.5-78.7% relative humidity (5-15 L/min range) at ambient temperature (21-23 degrees C). The Vapotherm device achieved 99.9% relative humidity at a temperature setting of 37 degrees C (5-40 L/min). Both devices meet minimum humidification standards and offer practical new treatment options. The patient-selection criteria are primarily the severity of the patient's condition and cost.

Measurement of blood flow from an assist ventricle by computation of pneumatic driving parameters.

PubMed

Qian, K X

1992-03-01

The measurement of blood flow from an assist ventricle is important but sometimes difficult in artificial heart experiments. Along with the development of a pneumatic cylinder-piston driver coupled with a ventricular assist device, a simplified method for measuring pump flow was established. From driving parameters such as the piston (or cylinder) displacement and air pressure, the pump flow could be calculated by the use of the equation of state for an ideal gas. The results of this method are broadly in agreement with electromagnetic and Doppler measurements.

Evaluation of a Low-Cost Bubble CPAP System Designed for Resource-Limited Settings.

PubMed

Bennett, Desmond J; Carroll, Ryan W; Kacmarek, Robert M

2018-04-01

Respiratory compromise is a leading contributor to global neonatal death. CPAP is a method of treatment that helps maintain lung volume during expiration, promotes comfortable breathing, and improves oxygenation. Bubble CPAP is an effective alternative to standard CPAP. We sought to determine the reliability and functionality of a low-cost bubble CPAP device designed for low-resource settings. The low-cost bubble CPAP device was compared to a commercially available bubble CPAP system. The devices were connected to a lung simulator that simulated neonates of 4 different weights with compromised respiratory mechanics (∼1, ∼3, ∼5, and ∼10 kg). The devices' abilities to establish and maintain pressure and flow under normal conditions as well as under conditions of leak were compared. Multiple combinations of pressure levels (5, 8, and 10 cm H 2 O) and flow levels (3, 6, and 10 L/min) were tested. The endurance of both devices was also tested by running the systems continuously for 8 h and measuring the changes in pressure and flow. Both devices performed equivalently during the no-leak and leak trials. While our testing revealed individual differences that were statistically significant and clinically important (>10% difference) within specific CPAP and flow-level settings, no overall comparisons of CPAP or flow were both statistically significant and clinically important. Each device delivered pressures similar to the desired pressures, although the flows delivered by both machines were lower than the set flows in most trials. During the endurance trials, the low-cost device was marginally better at maintaining pressure, while the commercially available device was better at maintaining flow. The low-cost bubble CPAP device evaluated in this study is comparable to a bubble CPAP system used in developed settings. Extensive clinical trials, however, are necessary to confirm its effectiveness. Copyright © 2018 by Daedalus Enterprises.

Extensional flow of hyaluronic acid solutions in an optimized microfluidic cross-slot devicea

PubMed Central

Haward, S. J.; Jaishankar, A.; Oliveira, M. S. N.; Alves, M. A.; McKinley, G. H.

2013-01-01

We utilize a recently developed microfluidic device, the Optimized Shape Cross-slot Extensional Rheometer (OSCER), to study the elongational flow behavior and rheological properties of hyaluronic acid (HA) solutions representative of the synovial fluid (SF) found in the knee joint. The OSCER geometry is a stagnation point device that imposes a planar extensional flow with a homogenous extension rate over a significant length of the inlet and outlet channel axes. Due to the compressive nature of the flow generated along the inlet channels, and the planar elongational flow along the outlet channels, the flow field in the OSCER device can also be considered as representative of the flow field that arises between compressing articular cartilage layers of the knee joints during running or jumping movements. Full-field birefringence microscopy measurements demonstrate a high degree of localized macromolecular orientation along streamlines passing close to the stagnation point of the OSCER device, while micro-particle image velocimetry is used to quantify the flow kinematics. The stress-optical rule is used to assess the local extensional viscosity in the elongating fluid elements as a function of the measured deformation rate. The large limiting values of the dimensionless Trouton ratio, Tr ∼ O(50), demonstrate that these fluids are highly extensional-thickening, providing a clear mechanism for the load-dampening properties of SF. The results also indicate the potential for utilizing the OSCER in screening of physiological SF samples, which will lead to improved understanding of, and therapies for, disease progression in arthritis sufferers. PMID:24738010

Ion Heating and Flows in a High Power Helicon Source

NASA Astrophysics Data System (ADS)

Scime, Earl; Agnello, Riccardo; Furno, Ivo; Howling, Alan; Jacquier, Remy; Plyushchev, Gennady; Thompson, Derek

2017-10-01

We report experimental measurements of ion temperatures and flows in a high power, linear, magnetized, helicon plasma device, the Resonant Antenna Ion Device (RAID). RAID is equipped with a high power helicon source. Parallel and perpendicular ion temperatures on the order of 0.6 eV are observed for an rf power of 4 kW, suggesting that higher power helicon sources should attain ion temperatures in excess of 1 eV. The unique RAID antenna design produces broad, uniform plasma density and perpendicular ion temperature radial profiles. Measurements of the azimuthal flow indicate rigid body rotation of the plasma column of a few kHz. When configured with an expanding magnetic field, modest parallel ion flows are observed in the expansion region. The ion flows and temperatures are derived from laser induced fluorescence measurements of the Doppler resolved velocity distribution functions of argon ions. This work supported by U.S. National Science Foundation Grant No. PHY-1360278.

Extraction and evaluation of gas-flow-dependent features from dynamic measurements of gas sensors array

NASA Astrophysics Data System (ADS)

Kalinowski, Paweł; Woźniak, Łukasz; Jasiński, Grzegorz; Jasiński, Piotr

2016-11-01

Gas analyzers based on gas sensors are the devices which enable recognition of various kinds of volatile compounds. They have continuously been developed and investigated for over three decades, however there are still limitations which slow down the implementation of those devices in many applications. For example, the main drawbacks are the lack of selectivity, sensitivity and long term stability of those devices caused by the drift of utilized sensors. This implies the necessity of investigations not only in the field of development of gas sensors construction, but also the development of measurement procedures or methods of analysis of sensor responses which compensate the limitations of sensors devices. One of the fields of investigations covers the dynamic measurements of sensors or sensor-arrays response with the utilization of flow modulation techniques. Different gas delivery patterns enable the possibility of extraction of unique features which improves the stability and selectivity of gas detecting systems. In this article three utilized flow modulation techniques are presented, together with the proposition of the evaluation method of their usefulness and robustness in environmental pollutants detecting systems. The results of dynamic measurements of an commercially available TGS sensor array in the presence of nitrogen dioxide and ammonia are shown.

Intra-aneurysmal flow disruption after implantation of the Medina® Embolization Device depends on aneurysm neck coverage.

PubMed

Frölich, Andreas Maximilian; Nawka, Marie Teresa; Ernst, Marielle; Frischmuth, Isabell; Fiehler, Jens; Buhk, Jan-Hendrik

2018-01-01

Flow disruption achieved by braided intrasaccular implants is a novel treatment strategy for cerebrovascular aneurysms. We hypothesized that the degree of intra-aneurysmal flow disruption can be quantified in vitro and is influenced by device position across the aneurysm neck. We tested this hypothesis using the Medina® Embolization Device (MED). Ten different patient-specific elastic vascular models were manufactured. Models were connected to a pulsatile flow circuit, filled with a blood-mimicking fluid and treated by two operators using a single MED. Intra-aneurysmal flow velocity was measured using conventional and high-frequency digital subtraction angiography (HF-DSA) before and after each deployment. Aneurysm neck coverage by the implanted devices was assessed with flat detector computed tomography on a three-point Likert scale. A total of 80 individual MED deployments were performed by the two operators. The mean intra-aneurysmal flow velocity reduction after MED implantation was 33.6% (27.5-39.7%). No significant differences in neck coverage (p = 0.99) or flow disruption (p = 0.84) were observed between operators. The degree of flow disruption significantly correlated with neck coverage (ρ = 0.42, 95% CI: 0.21-0.59, p = 0.002) as well as with neck area (ρ = -0,35, 95% CI: -0.54 --0.13, p = 0.024). On multiple regression analysis, both neck coverage and total neck area were independent predictors of flow disruption. The degree of intra-aneurysmal flow disruption after MED implantation can be quantified in vitro and varies considerably between different aneurysms and different device configurations. Optimal device coverage across the aneurysm neck improves flow disruption and may thus contribute to aneurysm occlusion.

Guide to Flow Measurement for Electric Propulsion Systems

NASA Technical Reports Server (NTRS)

Frieman, Jason D.; Walker, Mitchell L. R.; Snyder, Steve

2013-01-01

In electric propulsion (EP) systems, accurate measurement of the propellant mass flow rate of gas or liquid to the thruster and external cathode is a key input in the calculation of thruster efficiency and specific impulse. Although such measurements are often achieved with commercial mass flow controllers and meters integrated into propellant feed systems, the variability in potential propellant options and flow requirements amongst the spectrum of EP power regimes and devices complicates meter selection, integration, and operation. At the direction of the Committee on Standards for Electric Propulsion Testing, a guide was jointly developed by members of the electric propulsion community to establish a unified document that contains the working principles, methods of implementation and analysis, and calibration techniques and recommendations on the use of mass flow meters in laboratory and spacecraft electric propulsion systems. The guide is applicable to EP devices of all types and power levels ranging from microthrusters to high-power ion engines and Hall effect thrusters. The establishment of a community standard on mass flow metering will help ensure the selection of the proper meter for each application. It will also improve the quality of system performance estimates by providing comprehensive information on the physical phenomena and systematic errors that must be accounted for during the analysis of flow measurement data. This paper will outline the standard methods and recommended practices described in the guide titled "Flow Measurement for Electric Propulsion Systems."

Device and method for measuring multi-phase fluid flow in a conduit using an elbow flow meter

DOEpatents

Ortiz, Marcos G.; Boucher, Timothy J.

1997-01-01

A system for measuring fluid flow in a conduit. The system utilizes pressure transducers disposed generally in line upstream and downstream of the flow of fluid in a bend in the conduit. Data from the pressure transducers is transmitted to a microprocessor or computer. The pressure differential measured by the pressure transducers is then used to calculate the fluid flow rate in the conduit. Control signals may then be generated by the microprocessor or computer to control flow, total fluid dispersed, (in, for example, an irrigation system), area of dispersal or other desired effect based on the fluid flow in the conduit.

Composition pulse time-of-flight mass flow sensor

DOEpatents

Harnett, Cindy K [Livermore, CA; Crocker, Robert W [Fremont, CA; Mosier, Bruce P [San Francisco, CA; Caton, Pamela F [Berkeley, CA; Stamps, James F [Livermore, CA

2007-06-05

A device for measuring fluid flow rates over a wide range of flow rates (<1 nL/min to >10 .mu.L/min) and at pressures at least as great as 2,000 psi. The invention is particularly adapted for use in microfluidic systems. The device operates by producing compositional variations in the fluid, or pulses, that are subsequently detected downstream from the point of creation to derive a flow rate. Each pulse, comprising a small fluid volume, whose composition is different from the mean composition of the fluid, can be created by electrochemical means, such as by electrolysis of a solvent, electrolysis of a dissolved species, or electrodialysis of a dissolved ionic species. Measurements of the conductivity of the fluid can be used to detect the arrival time of the pulses, from which the fluid flow rate can be determined. A pair of spaced apart electrodes can be used to produce the electrochemical pulse. In those instances where it is desired to measure a wide range of fluid flow rates a three electrode configuration in which the electrodes are spaced at unequal distances has been found to be desirable.

Aeroacoustic Characteristics of Model Jet Test Facility Flow Conditioners

NASA Technical Reports Server (NTRS)

Kinzie, Kevin W.; Henderson, Brenda S.; Haskin, Harry H.

2005-01-01

An experimental investigation of flow conditioning devices used to suppress internal rig noise in high speed, high temperature experimental jet facilities is discussed. The aerodynamic and acoustic characteristics of a number of devices including pressure loss and extraneous noise generation are measured. Both aerodynamic and acoustic characteristics are strongly dependent on the porosity of the flow conditioner and the closure ratio of the duct system. For unchoked flow conditioners, the pressure loss follows conventional incompressible flow models. However, for choked flow conditioners, a compressible flow model where the duct and flow conditioner system is modeled as a convergent-divergent nozzle can be used to estimate pressure loss. Choked flow conditioners generate significantly more noise than unchoked conditioners. In addition, flow conditioners with small hole diameters or sintered metal felt material generate less self-noise noise compared to flow conditioners with larger holes.

The Deformation of Polydimethylsiloxane (PDMS) Microfluidic Channels Filled with Embedded Circular Obstacles under Certain Circumstances.

PubMed

Roh, Changhyun; Lee, Jaewoong; Kang, Chankyu

2016-06-18

Experimental investigations were conducted to determine the influence of polydimethylsiloxane (PDMS) microfluidic channels containing aligned circular obstacles (with diameters of 172 µm and 132 µm) on the flow velocity and pressure drop under steady-state flow conditions. A significant PDMS bulging was observed when the fluid flow initially contacted the obstacles, but this phenomenon decreased in the 1 mm length of the microfluidic channels when the flow reached a steady-state. This implies that a microfluidic device operating with steady-state flows does not provide fully reliable information, even though less PDMS bulging is observed compared to quasi steady-state flow. Numerical analysis of PDMS bulging using ANSYS Workbench showed a relatively good agreement with the measured data. To verify the influence of PDMS bulging on the pressure drop and flow velocity, theoretical analyses were performed and the results were compared with the experimental results. The measured flow velocity and pressure drop data relatively matched well with the classical prediction under certain circumstances. However, discrepancies were generated and became worse as the microfluidic devices were operated under the following conditions: (1) restricted geometry of the microfluidic channels (i.e., shallow channel height, large diameter of obstacles and a short microchannel length); (2) operation in quasi-steady state flow; (3) increasing flow rates; and (4) decreasing amount of curing agent in the PDMS mixture. Therefore, in order to obtain reliable data a microfluidic device must be operated under appropriate conditions.

Performance evaluation of photoacoustic oximetry imaging systems using a dynamic blood flow phantom with tunable oxygen saturation

NASA Astrophysics Data System (ADS)

Vogt, William C.; Zhou, Xuewen; Andriani, Rudy; Wear, Keith A.; Garra, Brian S.; Pfefer, Joshua

2018-02-01

Photoacoustic Imaging (PAI) is an emerging technology with strong potential for broad clinical applications from breast cancer detection to cerebral monitoring due to its ability to compute maps of blood oxygen saturation (SO2) distribution in deep tissues using multispectral imaging. However, no well-validated consensus test methods currently exist for evaluating oximetry-specific performance characteristics of PAI devices. We have developed a phantombased flow system capable of rapid SO2 adjustment to serve as a test bed for elucidation of factors impacting SO2 measurement and quantitative characterization of device performance. The flow system is comprised of a peristaltic pump, membrane oxygenator, oxygen and nitrogen gas, and in-line oxygen, pH, and temperature sensors that enable real-time estimation of SO2 reference values. Bovine blood was delivered through breast-relevant tissue phantoms containing vessel-mimicking fluid channels, which were imaged using a custom multispectral PAI system. Blood was periodically drawn for SO2 measurement in a clinical-grade CO-oximeter. We used this flow phantom system to evaluate the impact of device parameters (e.g.,wavelength-dependent fluence corrections) and tissue parameters (e.g. fluid channel depth, blood SO2, spectral coloring artifacts) on oximetry measurement accuracy. Results elucidated key challenges in PAI oximetry and device design trade-offs, which subsequently allowed for optimization of system performance. This approach provides a robust benchtop test platform that can support PAI oximetry device optimization, performance validation, and clinical translation, and may inform future development of consensus test methods for performance assessment of photoacoustic oximetry imaging systems.

40 CFR 60.5407 - What are the requirements for monitoring of emissions and operations from my sweetening unit...

Code of Federal Regulations, 2013 CFR

2013-07-01

... concentration in the acid gas from the sweetening unit for each 24-hour period. At least one sample per 24-hour... sampling schedule. (3) The average acid gas flow rate from the sweetening unit. You must install and operate a monitoring device to continuously measure the flow rate of acid gas. The monitoring device...

40 CFR 60.5407 - What are the requirements for monitoring of emissions and operations from my sweetening unit...

Code of Federal Regulations, 2014 CFR

2014-07-01

... concentration in the acid gas from the sweetening unit for each 24-hour period. At least one sample per 24-hour... sampling schedule. (3) The average acid gas flow rate from the sweetening unit. You must install and operate a monitoring device to continuously measure the flow rate of acid gas. The monitoring device...

Flow control using audio tones in resonant microfluidic networks: towards cell-phone controlled lab-on-a-chip devices.

PubMed

Phillips, Reid H; Jain, Rahil; Browning, Yoni; Shah, Rachana; Kauffman, Peter; Dinh, Doan; Lutz, Barry R

2016-08-16

Fluid control remains a challenge in development of portable lab-on-a-chip devices. Here, we show that microfluidic networks driven by single-frequency audio tones create resonant oscillating flow that is predicted by equivalent electrical circuit models. We fabricated microfluidic devices with fluidic resistors (R), inductors (L), and capacitors (C) to create RLC networks with band-pass resonance in the audible frequency range available on portable audio devices. Microfluidic devices were fabricated from laser-cut adhesive plastic, and a "buzzer" was glued to a diaphragm (capacitor) to integrate the actuator on the device. The AC flowrate magnitude was measured by imaging oscillation of bead tracers to allow direct comparison to the RLC circuit model across the frequency range. We present a systematic build-up from single-channel systems to multi-channel (3-channel) networks, and show that RLC circuit models predict complex frequency-dependent interactions within multi-channel networks. Finally, we show that adding flow rectifying valves to the network creates pumps that can be driven by amplified and non-amplified audio tones from common audio devices (iPod and iPhone). This work shows that RLC circuit models predict resonant flow responses in multi-channel fluidic networks as a step towards microfluidic devices controlled by audio tones.

Diaphragmatic mobility in healthy subjects during incentive spirometry with a flow-oriented device and with a volume-oriented device.

PubMed

Yamaguti, Wellington Pereira dos Santos; Sakamoto, Eliana Takahama; Panazzolo, Danilo; Peixoto, Corina da Cunha; Cerri, Giovanni Guido; Albuquerque, André Luis Pereira

2010-01-01

To compare the diaphragmatic mobility of healthy subjects during incentive spirometry with a volume-oriented device, during incentive spirometry with a flow-oriented device, and during diaphragmatic breathing. To compare men and women in terms of diaphragmatic mobility during these three types of breathing exercises. We evaluated the pulmonary function and diaphragmatic mobility of 17 adult healthy volunteers (9 women and 8 men). Diaphragmatic mobility was measured via ultrasound during diaphragmatic breathing and during the use of the two types of incentive spirometers. Diaphragmatic mobility was significantly greater during the use of the volume-oriented incentive spirometer than during the use of the flow-oriented incentive spirometer (70.16 ± 12.83 mm vs. 63.66 ± 10.82 mm; p = 0.02). Diaphragmatic breathing led to a greater diaphragmatic mobility than did the use of the flow-oriented incentive spirometer (69.62 ± 11.83 mm vs. 63.66 ± 10.82 mm; p = 0.02). During all three types of breathing exercises, the women showed a higher mobility/FVC ratio than did the men. Incentive spirometry with a volume-oriented device and diaphragmatic breathing promoted greater diaphragmatic mobility than did incentive spirometry with a flow-oriented device. Women performed better on the three types of breathing exercises than did men.

[Feasibility Study on Digital Signal Processor and Gear Pump of Uroflowmeter Calibration Device].

PubMed

Yuan, Qing; Ji, Jun; Gao, Jiashuo; Wang, Lixin; Xiao, Hong

2016-08-01

It will cause hidden trouble on clinical application if the uroflowmeter is out of control.This paper introduces a scheme of uroflowmeter calibration device based on digital signal processor(DSP)and gear pump and shows studies of its feasibility.According to the research plan,we analyzed its stability,repeatability and linearity by building a testing system and carried out experiments on it.The flow test system is composed of DSP,gear pump and other components.The test results showed that the system could produce a stable water flow with high precision of repeated measurement and different flow rate.The test system can calibrate the urine flow rate well within the range of 9~50mL/s which has clinical significance,and the flow error is less than 1%,which meets the technical requirements of the calibration apparatus.The research scheme of uroflowmeter calibration device on DSP and gear pump is feasible.

Imaging Electron Motion in a Few Layer MoS2 Device

NASA Astrophysics Data System (ADS)

Bhandari, S.; Wang, K.; Watanabe, K.; Taniguchi, T.; Kim, P.; Westervelt, R. M.

2017-06-01

Ultrathin sheets of MoS2 are a newly discovered 2D semiconductor that holds great promise for nanoelectronics. Understanding the pattern of current flow will be crucial for developing devices. In this talk, we present images of current flow in MoS2 obtained with a Scanned Probe Microscope (SPM) cooled to 4 K. We previously used this technique to image electron trajectories in GaAs/AlGaAs heterostructures and graphene. The charged SPM tip is held just above the sample surface, creating an image charge inside the device that scatters electrons. By measuring the change in resistance ΔR while the tip is raster scanned above the sample, an image of electron flow is obtained. We present images of electron flow in an MoS2 device patterned into a hall bar geometry. A three-layer MoS2 sheet is encased by two hBN layers, top and bottom, and patterned into a hall-bar with multilayer graphene contacts. An SPM image shows the current flow pattern from the wide contact at the end of the device for a Hall density n = 1.3×1012 cm-2. The SPM tip tends to block flow, increasing the resistance R. The pattern of flow was also imaged for a narrow side contact on the sample. At density n = 5.4×1011 cm-2; the pattern seen in the SPM image is similar to the wide contact. The ability to image electron flow promises to be very useful for the development of ultrathin devices from new 2D materials.

Optimal MEMS device for mobility and zeta potential measurements using DC electrophoresis.

PubMed

Karam, Pascal R; Dukhin, Andrei; Pennathur, Sumita

2017-05-01

We have developed a novel microchannel geometry that allows us to perform simple DC electrophoresis to measure the electrophoretic mobility and zeta potential of analytes and particles. In standard capillary geometries, mobility measurements using DC fields are difficult to perform. Specifically, measurements in open capillaries require knowledge of the hard to measure and often dynamic wall surface potential. Although measurements in closed capillaries eliminate this requirement, the measurements must be performed at infinitesimally small regions of zero flow where the pressure driven-flow completely cancels the electroosmotic flow (Komagata Planes). Furthermore, applied DC fields lead to electrode polarization, further questioning the reliability and accuracy of the measurement. In contrast, our geometry expands and moves the Komagata planes to where velocity gradients are at a minimum, and thus knowledge of the precise location of a Komagata plane is not necessary. Additionally, our microfluidic device prevents electrode polarization because of fluid recirculation around the electrodes. We fabricated our device using standard MEMS fabrication techniques and performed electrophoretic mobility measurements on 500 nm fluorescently tagged polystyrene particles at various buffer concentrations. Results are comparable to two different commercial dynamic light scattering based particle sizing instruments. We conclude with guidelines to further develop this robust electrophoretic tool that allows for facile and efficient particle characterization. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Microfluidic diffusion diluter: bulging of PDMS microchannels under pressure-driven flow

NASA Astrophysics Data System (ADS)

Holden, Matthew A.; Kumar, Saurabh; Beskok, Ali; Cremer, Paul S.

2003-05-01

The bulging of microfluidic systems during pressure-driven flow is potentially a major consideration for polydimethylsiloxane (PDMS)-based devices. Microchannel cross-sectional areas can change drastically as a function of flow rate and downstream microchannel position. Such geometrical flexibility leads to difficulties in predicting convective/diffusive transport for these systems. We have previously introduced a non-dimensional parameter, kappa, for characterizing convection and diffusion behavior for pressure-driven flow in rigid all-glass systems. This paper describes a modification of that concept for application to non-rigid systems, which is accomplished by incorporating an experimental step to account for the bulging in PDMS/glass microsystems. Specifically, an experimental measurement of channel height by fluorescence microscopy is combined with the aforementioned theory to characterize convective/diffusive behavior at a single location in the device. This allowed the parameter kappa to be determined at that point and applied to predict fluid flow in the subsequent portion of the PDMS microsystem. This procedure was applied to a PDMS/glass microfluidic diffusion dilution (muDD) device designed for generating concentration gradients. Theoretically predicted and experimentally measured distributions of concentrations within the microsystem matched well.

New devices for flow measurements: Hot film and burial wire sensors, infrared imagery, liquid crystal, and piezo-electric model

NASA Technical Reports Server (NTRS)

Mcree, Griffith J., Jr.; Roberts, A. Sidney, Jr.

1991-01-01

An experimental program aimed at identifying areas in low speed aerodynamic research where infrared imaging systems can make significant contributions is discussed. Implementing a new technique, a long electrically heated wire was placed across a laminar flow. By measuring the temperature distribution along the wire with the IR imaging camera, the flow behavior was identified.

Cuff for Blood-Vessel Pressure Measurements

NASA Technical Reports Server (NTRS)

Shimizu, M.

1982-01-01

Pressure within blood vessel is measured by new cufflike device without penetration of vessel. Device continuously monitors blood pressure for up to 6 months or longer without harming vessel. Is especially useful for vessels smaller than 4 or 5 millimeters in diameter. Invasive methods damage vessel wall, disturb blood flow, and cause clotting. They do not always give reliable pressure measurements over prolonged periods.

Further development and testing of the metabolic gas analyzer

NASA Technical Reports Server (NTRS)

1973-01-01

Continued development of a metabolic monitor utilizing a mass spectrometer and digital computer to perform measurements and data reduction, is reported. The device prints-out breath-by-breath values for 02 consumption, C02 production, minute volume and tidal volume. The flow is measured by introduction of a tracer gas to the expired gas stream. Design modifications to reduce pressure drop in the flow splitter to one inch of water at 600 liters/min flow and to extend the range of linear flow measurement to 1000 liters/min are discussed.

Thermal transient anemometer

DOEpatents

Bailey, James L.; Vresk, Josip

1989-01-01

A thermal transient anemometer having a thermocouple probe which is utilized to measure the change in temperature over a period of time to provide a measure of fluid flow velocity. The thermocouple probe is located in the fluid flow path and pulsed to heat or cool the probe. The cooling of the heated probe or the heating of the cooled probe from the fluid flow over a period of time is measured to determine the fluid flow velocity. The probe is desired to be locally heated near the tip to increase the efficiency of devices incorporating the probe.

Flow profile measurement with multi-Mach probes on the HIST spherical torus device

NASA Astrophysics Data System (ADS)

Hashimoto, S.; Nishioka, T.; Ando, K.; Kikuchi, Y.; Fukumoto, N.; Nagata, M.

2008-11-01

Role of plasma flow during MHD relaxation and magnetic reconnection processes is still underlying physics. The HIST spherical torus can generate various spherical torus (ST) configurations by changing the external toroidal magnetic field. Especially, the flipped ST (F-ST) configuration has been for the first time found in the HIST device [1]. In the present study, plasma flow measurements were performed by multi-Mach probes in the ST and the F-ST configurations. In addition, the measured plasma flow was compared with that evaluated by an ion Doppler spectrometer (IDS) system and plasma images measured by a high-speed camera. As the result, it was shown that the toroidal plasma flow (˜ 20 km/s) at the location far from the plasma gun was clearly reversed after the transition from the ST to the F-ST. However, the direction of the toroidal flow was not changed near the plasma gun. Therefore, it can be considered that there are flipped and non-reversal regions in the plasma. The result agrees well with a magnetic configuration predicted by magnetic field measurements. The plasma images measured by the high-speed camera also indicated that a helically twisted structure appeared from the gun region, and it localized at the edge region. [1] M. Nagata et al., Phys. Rev. Lett. 90, pp. 225001-225004 (2003).

Device and method for measuring multi-phase fluid flow in a conduit using an elbow flow meter

DOEpatents

Ortiz, M.G.; Boucher, T.J.

1997-06-24

A system is described for measuring fluid flow in a conduit. The system utilizes pressure transducers disposed generally in line upstream and downstream of the flow of fluid in a bend in the conduit. Data from the pressure transducers is transmitted to a microprocessor or computer. The pressure differential measured by the pressure transducers is then used to calculate the fluid flow rate in the conduit. Control signals may then be generated by the microprocessor or computer to control flow, total fluid dispersed, (in, for example, an irrigation system), area of dispersal or other desired effect based on the fluid flow in the conduit. 2 figs.

Hydrometry's classical and Innovative methods and tools comparison for Stara river flows at Agios Germanos monitoring station in north-west Greece.

NASA Astrophysics Data System (ADS)

Filintas, Agathos, , Dr; Hatzigiannakis, Evagellos, , Dr; Arampatzis, George, , Dr; Ilias, Andreas; Panagopoulos, Andreas, , Dr; Hatzispiroglou, Ioannis

2015-04-01

The aim of the present study is a thorough comparison of hydrometry's conventional and innovative methods-tools for river flow monitoring. A case study was conducted in Stara river at Agios Germanos monitoring station (northwest Greece), in order to investigate possible deviations between conventional and innovative methods-tools on river flow velocity and discharge. For this study, two flowmeters were used, which manufac-tured in 2013 (OTT Messtechnik Gmbh, 2013), as follows: a) A conventional propeller flow velocity meter (OTT-Model C2) which is a me-chanical current flow meter with a certification of calibration BARGO, operated with a rod and a relocating device, along with a digital measuring device including an elec-tronic flow calculator, data logger and real time control display unit. The flowmeter has a measurement velocity range 0.025-4.000 m/s. b) An innovative electromagnetic flowmeter (OTT-Model MF pro) which it is con-sisted of a compact and light-weight sensor and a robust handheld unit. Both system components are designed to be attached to conventional wading rods. The electromag-netic flowmeter uses Faraday's Law of electromagnetic induction to measure the process flow. When an electrically conductive fluid flows along the meter, an electrode voltage is induced between a pair of electrodes placed at right angles to the direction of mag-netic field. The electrode voltage is directly proportional to the average fluid velocity. The electromagnetic flowmeter was operated with a rod and relocating device, along with a digital measuring device with various logging and graphical capabilities and vari-ous methods of velocity measurement (ISO/USGS standards). The flowmeter has a measurement velocity range 0.000-6.000 m/s. The river flow data were averaged over a pair measurement of 60+60 seconds and the measured river water flow velocity, depths and widths of the segments were used for the estimation of cross-section's mean flow velocity in each measured segment. Then it was used the mid-section method for the overall discharge calculation of all segments flow area. The cross-section characteristics, the river flow velocity of segments and the mean water flow velocity and discharge total profile were measured, calculated and an-notated respectively. A series of concurrent conventional and innovative (electromag-netic) flow measurements were performed during 2014. The results and statistical analysis showed that Froude number during the measurement period in all cases was Fr<1 which means that the water flow of the Stara river is classified as subcritical flow. The 12 months' study showed various advantages for the elec-tromagnetic sensor that is virtually maintenance-free because there are no moving parts, no calibration was required in practice, and it can be used even in the lowest water ve-locities from 0.000 m/s. Moreover, based on the concurrent hydromeasurements of the Stara River, on the velocity and discharge modelling and the statistical analysis, it was found that there was not a significant statistical difference (α=0.05) between mean velocity measured with a) conventional and b) electromagnetic method which seems to be more accurate in low velocities where a significant statistical difference was found. Acknowledgments Data in this study are collected in the framework of the elaboration of the national water resources monitoring network, supervised by the Special Secretariat for Water-Hellenic Ministry for the Environment and Climate Change. This project is elaborated in the framework of the operational program "Environment and Sustainable Development" which is co-funded by the National Strategic Reference Framework (NSRF) and the Public Investment Program (PIP).

Gas flow meter and method for measuring gas flow rate

DOEpatents

Robertson, Eric P.

2006-08-01

A gas flow rate meter includes an upstream line and two chambers having substantially equal, fixed volumes. An adjustable valve may direct the gas flow through the upstream line to either of the two chambers. A pressure monitoring device may be configured to prompt valve adjustments, directing the gas flow to an alternate chamber each time a pre-set pressure in the upstream line is reached. A method of measuring the gas flow rate measures the time required for the pressure in the upstream line to reach the pre-set pressure. The volume of the chamber and upstream line are known and fixed, thus the time required for the increase in pressure may be used to determine the flow rate of the gas. Another method of measuring the gas flow rate uses two pressure measurements of a fixed volume, taken at different times, to determine the flow rate of the gas.

Optical measurement of transverse molecular diffusion in a microchannel.

PubMed Central

Kamholz, A E; Schilling, E A; Yager, P

2001-01-01

Quantitative analysis of molecular diffusion is a necessity for the efficient design of most microfluidic devices as well as an important biophysical method in its own right. This study demonstrates the rapid measurement of diffusion coefficients of large and small molecules in a microfluidic device, the T-sensor, by means of conventional epifluorescence microscopy. Data were collected by monitoring the transverse flux of analyte from a sample stream into a second stream flowing alongside it. As indicated by the low Reynolds numbers of the system (< 1), flow is laminar, and molecular transport between streams occurs only by diffusion. Quantitative determinations were made by fitting data with predictions of a one-dimensional model. Analysis was made of the flow development and its effect on the distribution of diffusing analyte using a three-dimensional modeling software package. Diffusion coefficients were measured for four fluorescently labeled molecules: fluorescein-biotin, insulin, ovalbumin, and streptavidin. The resulting values differed from accepted results by an average of 2.4%. Microfluidic system parameters can be selected to achieve accurate diffusion coefficient measurements and to optimize other microfluidic devices that rely on precise transverse transport of molecules. PMID:11259309

Dispersion of a Nanoliter Bolus in Microfluidic Co-Flow.

PubMed

Conway, A J; Saadi, W M; Sinatra, F L; Kowalski, G; Larson, D; Fiering, J

2014-03-01

Microfluidic systems enable reactions and assays on the scale of nanoliters. However, at this scale nonuniformities in sample delivery become significant. To determine the fundamental minimum sample volume required for a particular device, a detailed understanding of mass transport is required. Co-flowing laminar streams are widely used in many devices, but typically only in the steady-state. Because establishing the co-flow steady-state consumes excess sample volume and time, there is a benefit to operating devices in the transient state, which predominates as the volume of the co-flow reactor decreases. Analysis of the co-flow transient has been neglected thus far. In this work we describe the fabrication of a pneumatically controlled microfluidic injector constructed to inject a discrete 50nL bolus into one side of a two-stream co-flow reactor. Using dye for image analysis, injections were performed at a range of flow rates from 0.5-10μL/min, and for comparison we collected the co-flow steady-state data for this range. The results of the image analysis were also compared against theory and simulations for device validation. For evaluation, we established a metric that indicates how well the mass distribution in the bolus injection approximates steady-state co-flow. Using such analysis, transient-state injections can approximate steady-state conditions within predefined errors, allowing straight forward measurements to be performed with reduced reagent consumption.

System-on-fluidics immunoassay device integrating wireless radio-frequency-identification sensor chips.

PubMed

Yazawa, Yoshiaki; Oonishi, Tadashi; Watanabe, Kazuki; Shiratori, Akiko; Funaoka, Sohei; Fukushima, Masao

2014-09-01

A simple and sensitive point-of-care-test (POCT) device for chemiluminescence (CL) immunoassay was devised and tested. The device consists of a plastic flow-channel reactor and two wireless-communication sensor chips, namely, a photo-sensor chip and a temperature-sensor chip. In the flow-channel reactor, a target antigen is captured by an antibody immobilized on the inner wall of the flow-channel and detected with enzyme labeled antibody by using CL substrate. The CL signal corresponding to the amount of antigen is measured by a newly developed radio-frequency-identification (RFID) sensor, which enables batteryless operation and wireless data communication with an external reader. As for the POCT device, its usage environment, especially temperature, varies for each measurement. Hence, temperature compensation is a key issue in regard to eliminating dark-signal fluctuation, which is a major factor in deterioration of the precision of the POCT device. A two-stage temperature-compensation scheme was adopted. As for the first stage, the signals of two photodiodes, one with an open window and one with a sealed window, integrated on the photo-sensor chip are differentiated to delete the dark signal. As for the second stage, the differentiated signal fluctuation caused by a temperature variation is compensated by using the other sensor chip (equipped with a temperature sensor). The dark-level fluctuation caused by temperature was reduced from 0.24 to 0.02 pA/°C. The POCT device was evaluated as a CL immunoassay of thyroid-stimulating hormone (TSH). The flow rate of the CL reagent in the flow channel was optimized. As a result, the detection limit of the POCT device was 0.08 ng/ml (i.e., 0.4 μIU/ml). Copyright © 2014 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

Design and initial evaluation of a portable in situ runoff and sediment monitoring device

NASA Astrophysics Data System (ADS)

Sun, Tao; Cruse, Richard M.; Chen, Qiang; Li, Hao; Song, Chunyu; Zhang, Xingyi

2014-11-01

An inexpensive portable runoff and sediment monitoring device (RSMD) requiring no external electric power was developed for measuring water runoff and associated sediment loss from field plots ranging from 0.005 to 0.1 ha. The device consists of runoff gauge, sediment mixing and sectional subsampling assemblies. The runoff hydrograph is determined using a calibrated tipping bucket. The sediment mixing assembly minimizes fluid splash while mixing the runoff water/sediment mixture prior to subsampling this material. Automatic flow-proportional sampling utilizes mechanical power supplied by the tipping bucket action, with power transmitted to the sample collection assembly via the tipping bucket pivot bar. Runoff is well-mixed and subdivided twice before subsamples are collected for analysis. The resolution of this device for a 100 m2 plot is 0.025 mm of runoff; the device is able to capture maximum flow rates up to 82 mm h-1 in a plot of the same dimension. Calibration results indicated the maximum error is 2.1% for estimating flow rate and less than 10% for sediment concentration in most of the flow range. The RSMD was assessed by measuring field runoff and soil loss from different tillage and slope treatments for a single natural rainfall event. Results were in close agreement with those in published literature, giving additional evidence that this device is performing acceptably well. The RSMD is uniquely adapted for a wide range of field sites, especially for those without electric power, making it a useful tool for studying soil management strategies.

Frequency tuning allows flow direction control in microfluidic networks with passive features.

PubMed

Jain, Rahil; Lutz, Barry

2017-05-02

Frequency tuning has emerged as an attractive alternative to conventional pumping techniques in microfluidics. Oscillating (AC) flow driven through a passive valve can be rectified to create steady (DC) flow, and tuning the excitation frequency to the characteristic (resonance) frequency of the underlying microfluidic network allows control of flow magnitude using simple hardware, such as an on-chip piezo buzzer. In this paper, we report that frequency tuning can also be used to control the direction (forward or backward) of the rectified DC flow in a single device. Initially, we observed that certain devices provided DC flow in the "forward" direction expected from previous work with a similar valve geometry, and the maximum DC flow occurred at the same frequency as a prominent peak in the AC flow magnitude, as expected. However, devices of a slightly different geometry provided the DC flow in the opposite direction and at a frequency well below the peak AC flow. Using an equivalent electrical circuit model, we found that the "forward" DC flow occurred at the series resonance frequency (with large AC flow peak), while the "backward" DC flow occurred at a less obvious parallel resonance (a valley in AC flow magnitude). We also observed that the DC flow occurred only when there was a measurable differential in the AC flow magnitude across the valve, and the DC flow direction was from the channel with large AC flow magnitude to that with small AC flow magnitude. Using these observations and the AC flow predictions from the equivalent circuit model, we designed a device with an AC flowrate frequency profile that was expected to allow the DC flow in opposite directions at two distinct frequencies. The fabricated device showed the expected flow reversal at the expected frequencies. This approach expands the flow control toolkit to include both magnitude and direction control in frequency-tuned microfluidic pumps. The work also raises interesting questions about the origin of flow reversal behavior that may be addressed by the further study of the circuit model behavior or dynamic modeling of the fluid-solid mechanics of the valve under the AC flow.

Modelling and optimization of a wellhead gas flowmeter using concentric pipes

NASA Astrophysics Data System (ADS)

Nec, Yana; Huculak, Greg

2017-09-01

A novel configuration of a landfill wellhead was analysed to measure the flow rate of gas extracted from sanitary landfills. The device provides access points for pressure measurement integral to flow rate computation similarly to orifice and Venturi meters, and has the advantage of eliminating the problem of water condensation often impairing the accuracy thereof. It is proved that the proposed configuration entails comparable computational complexity and negligible sensitivity to geometric parameters. Calibration for the new device was attained using a custom optimization procedure, operating on a quadri-dimensional parameter surface evincing discontinuity and non-smoothness.

A New Metre for Cheap, Quick, Reliable and Simple Thermal Transmittance (U-Value) Measurements in Buildings.

PubMed

Andújar Márquez, José Manuel; Martínez Bohórquez, Miguel Ángel; Gómez Melgar, Sergio

2017-09-03

This paper deals with the thermal transmittance measurement focused on buildings and specifically in building energy retrofitting. Today, if many thermal transmittance measurements in a short time are needed, the current devices, based on the measurement of the heat flow through the wall, cannot carry out them, except if a great amount of devices are used at once along with intensive and tedious post-processing and analysis work. In this paper, from well-known physical laws, authors develop a methodology based on three temperatures measurements, which is implemented by a novel thermal transmittance metre. The paper shows its development step by step. As a result the developed device is modular, scalable, and fully wireless; it is capable of taking as many measurements at once as user needs. The developed system is compared working together on a same test to the currently used one based on heat flow. The results show that the developed metre allows carrying out thermal transmittance measurements in buildings in a cheap, quick, reliable and simple way.

Analysis of counter flow of corona wind for heat transfer enhancement

NASA Astrophysics Data System (ADS)

Shin, Dong Ho; Baek, Soo Hong; Ko, Han Seo

2018-03-01

A heat sink for cooling devices using the counter flow of a corona wind was developed in this study. Detailed information about the numerical investigations of forced convection using the corona wind was presented. The fins of the heat sink using the counter flow of a corona wind were also investigated. The corona wind generator with a wire-to-plate electrode arrangement was used for generating the counter flow to the fin. The compact and simple geometric characteristics of the corona wind generator facilitate the application of the heat sink using the counter flow, demonstrating the heat sink is effective for cooling electronic devices. Parametric studies were performed to analyze the effect of the counter flow on the fins. Also, the velocity and temperature were measured experimentally for the test mock-up of the heat sink with the corona wind generator to verify the numerical results. From a numerical study, the type of fin and its optimal height, length, and pitch were suggested for various heat fluxes. In addition, the correlations to calculate the mass of the developed heat sink and its cooling performance in terms of the heat transfer coefficient were derived. Finally, the cooling efficiencies corresponding to the mass, applied power, total size, and noise of the devices were compared with the existing commercial central processing unit (CPU) cooling devices with rotor fans. As a result, it was confirmed that the heat sink using the counter flow of the corona wind showed appropriate efficiencies for cooling electronic devices, and is a suitable replacement for the existing cooling device for high power electronics.

Measurement and Estimation of Riverbed Scour in a Mountain River

NASA Astrophysics Data System (ADS)

Song, L. A.; Chan, H. C.; Chen, B. A.

2016-12-01

Mountains are steep with rapid flows in Taiwan. After installing a structure in a mountain river, scour usually occurs around the structure because of the high energy gradient. Excessive scouring has been reported as one of the main causes of failure of river structures. The scouring disaster related to the flood can be reduced if the riverbed variation can be properly evaluated based on the flow conditions. This study measures the riverbed scour by using an improved "float-out device". Scouring and hydrodynamic data were simultaneously collected in the Mei River, Nantou County located in central Taiwan. The semi-empirical models proposed by previous researchers were used to estimate the scour depths based on the measured flow characteristics. The differences between the measured and estimated scour depths were discussed. Attempts were then made to improve the estimating results by developing a semi-empirical model to predict the riverbed scour based on the local field data. It is expected to setup a warning system of river structure safety by using the flow conditions. Keywords: scour, model, float-out device

Triaxial thermopile array geo-heat-flow sensor

DOEpatents

Carrigan, C.R.; Hardee, H.C.; Reynolds, G.D.; Steinfort, T.D.

1990-01-01

A triaxial thermopile array geothermal heat flow sensor is designed to measure heat flow in three dimensions in a reconstituted or unperturbed subsurface regime. Heat flow can be measured in conductive or permeable convective media. The sensor may be encased in protective pvc tubing and includes a plurality of thermistors and an array of heat flow transducers produce voltage proportional to heat flux along the subsurface regime and permit direct measurement of heat flow in the subsurface regime. The presence of the thermistor array permits a comparison to be made between the heat flow estimates obtained from the transducers and heat flow calculated using temperature differences and Fourier's Law. The device is extremely sensitive with an accuracy of less than 0.1 Heat Flow Units (HFU) and may be used for long term readings. 6 figs.

Comparative in vitro flow study of 3 different Ex-PRESS miniature glaucoma device models.

PubMed

Estermann, Stephan; Yuttitham, Kanokwan; Chen, Julie A; Lee, On-Tat; Stamper, Robert L

2013-03-01

To determine the flow characteristics of the 3 different models of the Ex-PRESS miniature glaucoma device in a controlled laboratory study. The 3 different Ex-PRESS models (P-50, R-50, and P-200; Optonol Ltd; now Alcon Lab) were tested using a gravity-driven flow test. Three samples of each of the 3 Ex-PRESS models were subjected to a constant gravitational force of fluid at 5 different pressure levels (5 to 25 mm Hg). Four measurements per sample were taken at each pressure level. The main outcome measure was flow rate (Q) (µL/min). Resistance (R) was calculated by dividing pressure (P) by the measured flow (Q). The flow rate was primarily pressure dependent. The P-200 model (internal diameter 200 µm) showed a statistically significant higher flow rate and lower resistance compared with both the P-50 and R-50 models (internal diameter 50 µm) (P<0.0001). The P-50 and R-50 models demonstrated similar flow rates (P=0.08) despite their difference in tube length (2.64 vs. 2.94 mm). The 3 models of the Ex-PRESS mini shunt behaved in vitro as simple flow resistors by creating a relatively constant resistance to flow. Tube diameter was the only parameter with significant impact on flow and resistance. All models demonstrated flow rates per unit of pressure much higher than the outflow facility of a healthy human eye.

Comprehensive theory of the Deans' switch as a variable flow splitter: fluid mechanics, mass balance, and system behavior.

PubMed

Boeker, Peter; Leppert, Jan; Mysliwietz, Bodo; Lammers, Peter Schulze

2013-10-01

The Deans' switch is an effluent switching device based on controlling flows of carrier gas instead of mechanical valves in the analytical flow path. This technique offers high inertness and a wear-free operation. Recently new monolithic microfluidic devices have become available. In these devices the whole flow system is integrated into a small metal device with low thermal mass and leak-tight connections. In contrast to a mechanical valve-based system, a flow-controlled system is more difficult to calculate. Usually the Deans' switch is used to switch one inlet to one of two outlets, by means of two auxiliary flows. However, the Deans' switch can also be used to deliver the GC effluent with a specific split ratio to both outlets. The calculation of the split ratio of the inlet flow to the two outlets is challenging because of the asymmetries of the flow resistances. This is especially the case, if one of the outlets is a vacuum device, such as a mass spectrometer, and the other an atmospheric detector, e.g. a flame ionization detector (FID) or an olfactory (sniffing) port. The capillary flows in gas chromatography are calculated with the Hagen-Poiseuille equation of the laminar, isothermal and compressible flow in circular tubes. The flow resistances in the new microfluidic devices have to be calculated with the corresponding equation for rectangular cross-section microchannels. The Hagen-Poiseuille equation underestimates the flow to a vacuum outlet. A corrected equation originating from the theory of rarefied flows is presented. The calculation of pressures and flows of a Deans' switch based chromatographic system is done by the solution of mass balances. A specific challenge is the consideration of the antidiffusion resistor between the two auxiliary gas lines of the Deans' switch. A full solution for the calculation of the Deans' switch including this restrictor is presented. Results from validation measurements are in good accordance with the developed theories. A spreadsheet-based flow calculator is part of the Supporting Information.

CFD Approach To Investigate The Flow Characteristics In Bi-Directional Ventilated Disc Brake

NASA Astrophysics Data System (ADS)

Munisamy, Kannan M.; Yusoff, Mohd. Zamri; Shuaib, Norshah Hafeez; Thangaraju, Savithry K.

2010-06-01

This paper presents experimental and Computational Fluids Dynamics (CFD) investigations of the flow in ventilated brake discs. Development of an experiment rig with basic measuring devices are detailed out and following a validation study, the possible improvement in the brake cooling can be further analyzed using CFD analysis. The mass flow rate is determined from basic flow measurement technique following that the conventional bi-directional passenger car is simulated using commercial CFD software FLUENT™. The CFD simulation is used to investigate the flow characteristics in between blade flow of the bi-directional ventilated disc brake.

Flow Control and Measurement in Electric Propulsion Systems: Towards an AIAA Reference Standard

DTIC Science & Technology

2013-10-01

the spacecraft sensors, although some improvement can be made by averaging several measurements together. 3. Thermal Mass Gauging Thermal Mass...flow controllers (MFCs) to measure and control propellant into EP devices. To determine several key thruster performance parameters with a low level...the specified time interval may not be known. A first recourse is to perform several measurements and examine the linearity. In cases where the

Multi-transmitter/multi-receiver high-speed measurements of soil resistivity and induced polarization - Hydrological application

NASA Astrophysics Data System (ADS)

Gance, Julien; Texier, Benoît; Leite, Orlando; Bernard, Jean; Truffert, Catherine; Lebert, François; Yamashita, Yoshihiro

2016-04-01

Electrical resistivity tomography (ERT) is an adapted tool for the monitoring of soil moisture variations in aquifers (Binley et al., 2015). Nevertheless, in some specific cases, like for highly permeable soils or fractured aquifers, the measurements from the device can be slower than the water flow through the entire investigated zone. Therefore, the monitoring of such phenomena cannot be performed with classical devices. In such cases, we require a high-speed measurement of soils resistivity. Since 20 years, the speed of acquisition of the resistivity meters has been improved by the development of multi-channel devices allowing to perform multi-electrode (> 4) measurements. The switching capabilities of the actual devices allow to measure over long profiles up to hundreds of electrodes only using one transmitter. Based on this multi-receiver technology and on previous work from Yamashita et al. (2013), authors have developed a 250 W multi-transmitter device for the high speed measurement of resistivity and induced polarization. Current is therefore injected simultaneously in the soil through six injection electrodes. The injected current is coded for each transmitter using Code Division Multiple Access (CDMA, Yamashita et al., 2014) so that the different voltages induced by each sources can be reconstructed from the total potential measurement signal at each receiver, allowing to save acquisition time. The first operational prototype features 3 transmitters and 6 receivers. Its performances are compared to a mono-transmitter device for different sequences of acquisition in 2D and 3D configurations both in theory and on real field data acquired on a shallow sedimentary aquifer in the Loire valley in France. This device is promising for the accurate monitoring of rapid water flows in heterogeneous aquifers.

An evaluation of borehole flowmeters used to measure horizontal ground-water flow in limestones of Indiana, Kentucky, and Tennessee, 1999

USGS Publications Warehouse

Wilson, John T.; Mandell, Wayne A.; Paillet, Frederick L.; Bayless, E. Randall; Hanson, Randall T.; Kearl, Peter M.; Kerfoot, William B.; Newhouse, Mark W.; Pedler, William H.

2001-01-01

Three borehole flowmeters and hydrophysical logging were used to measure ground-water flow in carbonate bedrock at sites in southeastern Indiana and on the westcentral border of Kentucky and Tennessee. The three flowmeters make point measurements of the direction and magnitude of horizontal flow, and hydrophysical logging measures the magnitude of horizontal flowover an interval. The directional flowmeters evaluated include a horizontal heat-pulse flowmeter, an acoustic Doppler velocimeter, and a colloidal borescope flowmeter. Each method was used to measure flow in selected zones where previous geophysical logging had indicated water-producing beds, bedding planes, or other permeable features that made conditions favorable for horizontal-flow measurements. Background geophysical logging indicated that ground-water production from the Indiana test wells was characterized by inflow from a single, 20-foot-thick limestone bed. The Kentucky/Tennessee test wells produced water from one or more bedding planes where geophysical logs indicated the bedding planes had been enlarged by dissolution. Two of the three test wells at the latter site contained measurable vertical flow between two or more bedding planes under ambient hydraulic head conditions. Field measurements and data analyses for each flow-measurement technique were completed by a developer of the technology or by a contractor with extensive experience in the application of that specific technology. Comparison of the horizontal-flow measurements indicated that the three point-measurement techniques rarely measured the same velocities and flow directions at the same measurement stations. Repeat measurements at selected depth stations also failed to consistently reproduce either flow direction, flow magnitude, or both. At a few test stations, two of the techniques provided similar flow magnitude or direction but usually not both. Some of this variability may be attributed to naturally occurring changes in hydraulic conditions during the 1-month study period in August and September 1999. The actual velocities and flow directions are unknown; therefore, it is uncertain which technique provided the most accurate measurements of horizontal flow in the boreholes and which measurements were most representative of flow in the aquifers. The horizontal heat-pulse flowmeter consistently yielded flow magnitudes considerably less than those provided by the acoustic Doppler velocimeter and colloidal borescope. The design of the horizontal heat-pulse flowmeter compensates for the local acceleration of ground-water velocity in the open borehole. The magnitude of the velocities estimated from the hydrophysical logging were comparable to those of the horizontal heat-pulse flowmeter, presumably because the hydrophysical logging also effectively compensates for the effect of the borehole on the flow field and averages velocity over a length of borehole rather than at a point. The acoustic Doppler velocimeter and colloidal borescope have discrete sampling points that allow for measuring preferential flow velocities that can be substantially higher than the average velocity through a length of borehole. The acoustic Doppler velocimeter and colloidal borescope also measure flow at the center of the borehole where the acceleration of the flow field should be greatest. Of the three techniques capable of measuring direction and magnitude of horizontal flow, only the acoustic Doppler velocimeter measured vertical flow. The acoustic Doppler velocimeter consistently measured downward velocity in all test wells. This apparent downward flow was attributed, in part, to particles falling through the water column as a result of mechanical disturbance during logging. Hydrophysical logging yielded estimates of vertical flow in the Kentucky/Tennessee test wells. In two of the test wells, the hydrophysical logging involved deliberate isolation of water-producing bedding planes with a packer to ensure that small horizontal flow could be quantified without the presence of vertical flow. The presence of vertical flow in the Kentucky/Tennessee test wells may preclude the definitive measurement of horizontal flow without the use of effective packer devices. None of the point-measurement techniques used a packer, but each technique used baffle devices to help suppress the vertical flow. The effectiveness of these baffle devices is not known; therefore, the effect of vertical flow on the measurements cannot be quantified. The general lack of agreement among the point-measurement techniques in this study highlights the difficulty of using measurements at a single depth point in a borehole to characterize the average horizontal flow in a heterogeneous aquifer. The effective measurement of horizontal flow may depend on the precise depth at which measurements are made, and the measurements at a given depth may vary over time as hydraulic head conditions change. The various measurements also demonstrate that the magnitude and possibly the direction of horizontal flow are affected by the presence of the open borehole. Although there is a lack of agreement among the measurement techniques, these results could mean that effective characterization of horizontal flow in heterogeneous aquifers might be possible if data from many depth stations and from repeat measurements can be averaged over an extended time period. Complications related to vertical flow in the borehole highlights the importance of using background logging methods like vertical flowmeters or hydrophysical logging to characterize the borehole environment before horizontal-flow measurements are attempted. If vertical flow is present, a packer device may be needed to acquire definitive measurements of horizontal flow. Because hydrophysical logging provides a complete depth profile of the borehole, a strength of this technique is in identifying horizontal- and vertical-flow zones in a well. Hydrophysical logging may be most applicable as a screening method. Horizontal- flow zones identified with the hydrophysical logging then could be evaluated with one of the point-measurement techniques for quantifying preferential flow zones and flow directions. Additional research is needed to determine how measurements of flow in boreholes relate to flow in bedrock aquifers. The flowmeters may need to be evaluated under controlled laboratory conditions to determine which of the methods accurately measure ground-water velocities and flow directions. Additional research also is needed to investigate variations in flow direction with time, daily changes in velocity, velocity corrections for fractured bedrock aquifers and unconsolidated aquifers, and directional differences in individual wells for hydraulically separated flow zones.

Method and device for determining heats of combustion of gaseous hydrocarbons

NASA Technical Reports Server (NTRS)

Singh, Jag J. (Inventor); Sprinkle, Danny R. (Inventor); Puster, Richard L. (Inventor)

1988-01-01

A method and device is provided for a quick, accurate and on-line determination of heats of combustion of gaseous hydrocarbons. First, the amount of oxygen in the carrier air stream is sensed by an oxygen sensing system. Second, three individual volumetric flow rates of oxygen, carrier stream air, and hydrocrabon test gas are introduced into a burner. The hydrocarbon test gas is fed into the burner at a volumetric flow rate, n, measured by a flowmeter. Third, the amount of oxygen in the resulting combustion products is sensed by an oxygen sensing system. Fourth, the volumetric flow rate of oxygen is adjusted until the amount of oxygen in the combustion product equals the amount of oxygen previously sensed in the carrier air stream. This equalizing volumetric flow rate is m and is measured by a flowmeter. The heat of combustion of the hydrocrabon test gas is then determined from the ratio m/n.

Thermal transient anemometer

DOEpatents

Bailey, J.L.; Vresk, J.

1989-07-18

A thermal transient anemometer is disclosed having a thermocouple probe which is utilized to measure the change in temperature over a period of time to provide a measure of fluid flow velocity. The thermocouple probe is located in the fluid flow path and pulsed to heat or cool the probe. The cooling of the heated probe or the heating of the cooled probe from the fluid flow over a period of time is measured to determine the fluid flow velocity. The probe is desired to be locally heated near the tip to increase the efficiency of devices incorporating the probe. 12 figs.

Investigation of flows in LAPD and their relation to edge turbulence and intermittency

NASA Astrophysics Data System (ADS)

Schaffner, D.; Carter, T. A.; Friedman, B.; Vincena, S.; Auerbach, D. W.; Popovich, P.

2009-11-01

We report on measurements of spontaneous flows and turbulence in the Large Plasma Device (LAPD) at UCLA. Measurements of perpendicular and parallel flow using a six-sided Mach probe reveal edge-localized perpendicular flows. The source of this flow is under investigation and may be generated by boundary effects or turbulent processes. Particular cases where a plasma depletion zone is created, including inserting a blocking disk within the cathode region and forming a compressed column, are used to analyze the effects on plasma flows. Ultimately, the relationship between the flows, turbulence and intermittency---the formation of blobs---is sought.

Simultaneous Measurements of Geometric and Viscoelastic Properties of Hydrogel Microbeads Using Continuous-Flow Microfluidics with Embedded Electrodes.

PubMed

Niu, Ye; Zhang, Xu; Si, Ting; Zhang, Yuntian; Qi, Lin; Zhao, Gang; Xu, Ronald X; He, Xiaoming; Zhao, Yi

2017-12-01

Geometric and mechanical characterizations of hydrogel materials at the microscale are attracting increasing attention due to their importance in tissue engineering, regenerative medicine, and drug delivery applications. Contemporary approaches for measuring the these properties of hydrogel microbeads suffer from low-throughput, complex system configuration, and measurement inaccuracy. In this work, a continuous-flow device is developed to measure geometric and viscoelastic properties of hydrogel microbeads by flowing the microbeads through a tapered microchannel with an array of interdigitated microelectrodes patterned underneath the channel. The viscoelastic properties are derived from the trajectories of microbeads using a quasi-linear viscoelastic model. The measurement is independent of the applied volumetric flow rate. The results show that the geometric and viscoelastic properties of Ca-alginate hydrogel microbeads can be determined independently and simultaneously. The bulky high-speed optical systems are eliminated, simplifying the system configuration and making it a truly miniaturized device. A throughput of up to 394 microbeads min -1 is achieved. This study may provide a powerful tool for mechanical profiling of hydrogel microbeads to support their wide applications. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

[In vitro study of the flow duration of antibiotics solutions prepared in elastomeric infusion devices: effect of cold storage for 3 to 7days].

PubMed

Grangeon-Chapon, C; Robein-Dobremez, M-J; Pin, I; Trouiller, P; Allenet, B; Foroni, L

2015-09-01

Within the cystic fibrosis patients' home care, EMERAA network ("Together against Cystic fibrosis in Rhone-Alpes and Auvergne") organizes parenteral antibiotics cures at home prepared in elastomeric infusion devices by hospital pharmacies. However, patients and nurses found that the durations of infusion with these devices were often longer than the nominal duration of infusion indicated by their manufacturer. This study aimed to identify the potential different causes in relation to these discordances. Three hundred and ninety devices of two different manufacturers are tested in different experimental conditions: three antibiotics each at two different doses, duration of cold storage (three days or seven days) or immediate tests without cold storage, preparation and storage of the solution in the device (protocol Device) or transfer in the device just before measurement (protocol Pocket). All tests highlighted a longer flow duration for devices prepared according to the protocol Device versus the protocol Pocket (P=0.004). Flow duration is increased in the case of high doses of antibiotics with high viscosity such as piperacilline/tazobactam. The results of this in vitro study showed the impact of: (1) the time between the filling of the device and the flow of the solution; (2) cold storage of elastomeric infusion devices; (3) concentration of antibiotics and therefore the viscosity of the solution to infuse. It is therefore essential that health care teams are aware of factors, which may lead to longer infusion durations with these infusion devices. When the additional time for infusion remain acceptable, it should be necessary to inform the patient and to relativize these lengthening compared to many benefits that these devices provide for home care. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

Label-free viscosity measurement of complex fluids using reversal flow switching manipulation in a microfluidic channel

PubMed Central

Jun Kang, Yang; Ryu, Jeongeun; Lee, Sang-Joon

2013-01-01

The accurate viscosity measurement of complex fluids is essential for characterizing fluidic behaviors in blood vessels and in microfluidic channels of lab-on-a-chip devices. A microfluidic platform that accurately identifies biophysical properties of blood can be used as a promising tool for the early detections of cardiovascular and microcirculation diseases. In this study, a flow-switching phenomenon depending on hydrodynamic balancing in a microfluidic channel was adopted to conduct viscosity measurement of complex fluids with label-free operation. A microfluidic device for demonstrating this proposed method was designed to have two inlets for supplying the test and reference fluids, two side channels in parallel, and a junction channel connected to the midpoint of the two side channels. According to this proposed method, viscosities of various fluids with different phases (aqueous, oil, and blood) in relation to that of reference fluid were accurately determined by measuring the switching flow-rate ratio between the test and reference fluids, when a reverse flow of the test or reference fluid occurs in the junction channel. An analytical viscosity formula was derived to measure the viscosity of a test fluid in relation to that of the corresponding reference fluid using a discrete circuit model for the microfluidic device. The experimental analysis for evaluating the effects of various parameters on the performance of the proposed method revealed that the fluidic resistance ratio (RJL/RL, fluidic resistance in the junction channel (RJL) to fluidic resistance in the side channel (RL)) strongly affects the measurement accuracy. The microfluidic device with smaller RJL/RL values is helpful to measure accurately the viscosity of the test fluid. The proposed method accurately measured the viscosities of various fluids, including single-phase (Glycerin and plasma) and oil-water phase (oil vs. deionized water) fluids, compared with conventional methods. The proposed method was also successfully applied to measure viscosities of blood with varying hematocrits, chemically fixed RBCS, and channel sizes. Based on these experimental results, the proposed method can be effectively used to measure the viscosities of various fluids easily, without any fluorescent labeling and tedious calibration procedures. PMID:24404040

Numerical Simulation of Flow Field Within Parallel Plate Plastometer

NASA Technical Reports Server (NTRS)

Antar, Basil N.

2002-01-01

Parallel Plate Plastometer (PPP) is a device commonly used for measuring the viscosity of high polymers at low rates of shear in the range 10(exp 4) to 10(exp 9) poises. This device is being validated for use in measuring the viscosity of liquid glasses at high temperatures having similar ranges for the viscosity values. PPP instrument consists of two similar parallel plates, both in the range of 1 inch in diameter with the upper plate being movable while the lower one is kept stationary. Load is applied to the upper plate by means of a beam connected to shaft attached to the upper plate. The viscosity of the fluid is deduced from measuring the variation of the plate separation, h, as a function of time when a specified fixed load is applied on the beam. Operating plate speeds measured with the PPP is usually in the range of 10.3 cm/s or lower. The flow field within the PPP can be simulated using the equations of motion of fluid flow for this configuration. With flow speeds in the range quoted above the flow field between the two plates is certainly incompressible and laminar. Such flows can be easily simulated using numerical modeling with computational fluid dynamics (CFD) codes. We present below the mathematical model used to simulate this flow field and also the solutions obtained for the flow using a commercially available finite element CFD code.

Flow-induced voltage generation in non-ionic liquids over monolayer graphene

NASA Astrophysics Data System (ADS)

Ho Lee, Seung; Jung, Yousung; Kim, Soohyun; Han, Chang-Soo

2013-02-01

To clarify the origin of the flow-induced voltage generation in graphene, we prepared a new experimental device whose electrodes were aligned perpendicular to the flow with a non-ionic liquid. We found that significant voltage in our device was generated with increasing flow velocity, thereby confirming that voltage was due to an intrinsic interaction between graphene and the flowing liquid. To understand the mechanism of the observed flow-induced voltage generation, we systematically varied several important experimental parameters: flow velocity, electrode alignment, liquid polarity, and liquid viscosity. Based on these measurements, we suggest that polarity of the fluid is a significant factor in determining the extent of the voltage generated, and the major mechanism can be attributed to instantaneous potential differences induced in the graphene due to an interaction with polar liquids and to the momentum transferred from the flowing liquid to the graphene.

Design and nonlinear modeling of a sensitive sensor for the measurement of flow in mice.

PubMed

Bou Jawde, Samer; Smith, Bradford J; Sonnenberg, Adam; Bates, Jason H T; Suki, Bela

2018-06-07

While many studies rely on flow and pressure measurements in small animal models of respiratory disease, such measurements can however be inaccurate and difficult to obtain. Thus, the goal of this study was to design and implement an easy to manufacture and accurate sensor capable of monitoring flow. We designed and 3-D printed a flowmeter and utilized parametric (resistance and inertance) and nonparametric (polynomial and Volterra series) system identification to characterize the device. The sensor was tested in a closed system for apparent flow using the common mode rejection ratio (CMRR). The sensor properly measured tidal volumes and respiratory rates in spontaneously breathing mice. The device was used to evaluate a ventilator's ability to deliver a prescribed volume before and after lung injury. The parametric and polynomial models provided a reasonable prediction of the independently measured flow (Coefficient of determination (Cv)=0.9591 and 0.9147 respectively), but the Volterra series of the 1st, 2nd, and 3rd order with a memory of six time points provided better fits (Cv=0.9775, 0.9787, and 0.9954, respectively). At and below the mouse breathing frequency (1-5 Hz), CMRR was higher than 40 dB. Following lung injury, the sensor revealed a significant drop in delivered tidal volume. We demonstrate that the application of nonparametric nonlinear Volterra series modeling in combination with 3-D printing technology allows the inexpensive and rapid fabrication of an accurate flow sensor for continuously measuring small flows in various physiological conditions. © 2018 Institute of Physics and Engineering in Medicine.

Flow rate measurement in a volume

DOE Office of Scientific and Technical Information (OSTI.GOV)

Galvez, Cristhian

A system for measuring flow rate within a volume includes one or more transmission devices that transmit one or more signals through fluid contained within the volume. The volume may be bounded, at least in part, by an outer structure and by an object at least partially contained within the outer structure. A transmission device located at a first location of the outer structure transmits a first signal to a second location of the outer structure. A second signal is transmitted through the fluid from the second location to a third location of the outer structure. The flow rate ofmore » the fluid within the volume may be determined based, at least in part, on the time of flight of both the first signal and the second signal.« less

In vivo quantification of intraventricular flow during left ventricular assist device support

NASA Astrophysics Data System (ADS)

Vu, Vi; Wong, Kin; Del Alamo, Juan; Aguilo, Pablo M. L.; May-Newman, Karen; Department of Bioengineering, San Diego State University Collaboration; Department of Mechanical; Aerospace Engineering, University of California San Diego Collaboration; Mechanical Assist Device Program, Sharp Memorial Hospital Collaboration

2014-11-01

Left ventricular assist devices (LVADs) are mechanical pumps that are surgically connected to the left ventricle (LV) and aorta to increase aortic flow and end-organ perfusion. Clinical studies have demonstrated that LVADs improve patient health and quality of life and significantly reduce the mortality of cardiac failure. However, In the presence of left ventricular assisted devices (LVAD), abnormal flow patterns and stagnation regions are often linked to thrombosis. The aim of our study is to evaluate the flow patterns in the left ventricle of the LVAD-assisted heart, with a focus on alterations in vortex development and blood stasis. To this aim, we applied color Doppler echocardiography to measure 2D, time resolved velocity fields in patients before and after implantation of LVADs. In agreement with our previous in vitro studies (Wong et al., Journal of Biomechanics 47, 2014), LVAD implantation resulted in decreased flow velocities and increased blood residence time near the outflow tract. The variation of residence time changes with LVAD operational speed was characterized for each patient.

NMRI Measurements of Flow of Granular Mixtures

NASA Technical Reports Server (NTRS)

Nakagawa, Masami; Waggoner, R. Allen; Fukushima, Eiichi

1996-01-01

We investigate complex 3D behavior of granular mixtures in shaking and shearing devices. NMRI can non-invasively measure concentration, velocity, and velocity fluctuations of flows of suitable particles. We investigate origins of wall-shear induced convection flow of single component particles by measuring the flow and fluctuating motion of particles near rough boundaries. We also investigate if a mixture of different size particles segregate into their own species under the influence of external shaking and shearing disturbances. These non-invasive measurements will reveal true nature of convecting flow properties and wall disturbance. For experiments in a reduced gravity environment, we will design a light weight NMR imager. The proof of principle development will prepare for the construction of a complete spaceborne system to perform experiments in space.

Triaxial thermopile array geo-heat-flow sensor

DOEpatents

Carrigan, Charles R.; Hardee, Harry C.; Reynolds, Gerald D.; Steinfort, Terry D.

1992-01-01

A triaxial thermopile array geothermal heat flow sensor is designed to measure heat flow in three dimensions in a reconstituted or unperturbed subsurface regime. Heat flow can be measured in conductive or permeable convective media. The sensor may be encased in protective pvc tubing and includes a plurality of thermistors and an array of heat flow transducers arranged in a vertical string. The transducers produce voltage proportional to heat flux along the subsurface regime and permit direct measurement of heat flow in the subsurface regime. The presence of the thermistor array permits a comparison to be made between the heat flow estimates obtained from the transducers and heat flow calculated using temperature differences and Fourier's Law. The device is extremely sensitive with an accuracy of less than 0.1 Heat Flow Units (HFU) and may be used for long term readings.

Air elimination capability in rapid infusion systems.

PubMed

Zoremba, N; Gruenewald, C; Zoremba, M; Rossaint, R; Schaelte, G

2011-11-01

Pressure infusion devices are used in clinical practice to apply large volumes of fluid over a short period of time. Although air infusion is a major complication, they have limited capability to detect and remove air during pressure infusion. In this investigation, we tested the air elimination capabilities of the Fluido(®) (The Surgical Company), Level 1(®) (Level 1 Technologies Inc.) and Ranger(®) (Augustine Medical GmbH) pressure infusion devices. Measurements were undertaken with a crystalloid solution during an infusion flow of 100, 200, 400 and 800 ml.min(-1). Four different volumes of air (25, 50, 100 and 200 ml) were injected as boluses in one experimental setting, or infused continuously over the time needed to perfuse 2 l saline in the other setting. The perfusion fluid was collected in an airtight infusion bag and the amount of air obtained in the bag was measured. The delivered air volume was negligible and would not cause any significant air embolism in all experiments. In our experimental setting, we found, during high flow, an increased amount of uneliminated air in all used devices compared with lower perfusion flows. All tested devices had a good air elimination capability. The use of ultrasonic air detection coupled with an automatic shutoff is a significant safety improvement and can reliably prevent accidental air embolism at rapid flows. © 2011 The Authors. Anaesthesia © 2011 The Association of Anaesthetists of Great Britain and Ireland.

Portable device and method for determining permeability characteristics of earth formations

DOEpatents

Shuck, Lowell Z.

1977-01-01

The invention is directed to a device which is used for determining permeability characteristics of earth formations at the surface thereof. The determination of the maximum permeability direction and the magnitude of permeability are achieved by employing a device comprising a housing having a central fluid-injection port surrounded by a plurality of spaced-apart fluid flow and pressure monitoring ports radially extending from the central injection port. With the housing resting on the earth formation in a relatively fluid-tight manner as provided by an elastomeric pad disposed therebetween, fluid is injected through the central port into the earth formation and into registry with the fluid-monitoring ports disposed about the injection port. The fluid-monitoring ports are selectively opened and the flow of the fluid through the various fluid ports is measured so as to provide a measurement of flow rates and pressure distribution about the center hole which is indicative on the earth formation permeability direction and magnitude. For example, the azimuthal direction of the fluid-monitoring ports in the direction through which the greatest amount of injected fluid flows as determined by the lowest pressure distribution corresponds to the direction of maximum permeability in the earth formation.

Performance characteristics of a novel blood bag in-line closure device and subsequent product quality assessment

PubMed Central

Serrano, Katherine; Levin, Elena; Culibrk, Brankica; Weiss, Sandra; Scammell, Ken; Boecker, Wolfgang F; Devine, Dana V

2010-01-01

BACKGROUND In high-volume processing environments, manual breakage of in-line closures can result in repetitive strain injury (RSI). Furthermore, these closures may be incorrectly opened causing shear-induced hemolysis. To overcome the variability of in-line closure use and minimize RSI, Fresenius Kabi developed a new in-line closure, the CompoFlow, with mechanical openers. STUDY DESIGN AND METHODS The consistency of the performance of the CompoFlow closure device was assessed, as was its effect on component quality. A total of 188 RBC units using CompoFlow blood bag systems and 43 using the standard bag systems were produced using the buffy coat manufacturing method. Twenty-six CompoFlow platelet (PLT) concentrates and 10 control concentrates were prepared from pools of four buffy coats. RBCs were assessed on Days 1, 21, and 42 for cellular variables and hemolysis. PLTs were assessed on Days 1, 3, and 7 for morphology, CD62P expression, glucose, lactate, and pH. A total of 308 closures were excised after processing and the apertures were measured using digital image analysis. RESULTS The use of the CompoFlow device significantly improved the mean extraction time with 0.46 ± 0.11 sec/mL for the CompoFlow units and 0.52 ± 0.13 sec/mL for the control units. The CompoFlow closures showed a highly reproducible aperture after opening (coefficient of variation, 15%) and the device always remained opened. PLT and RBC products showed acceptable storage variables with no differences between CompoFlow and control. CONCLUSIONS The CompoFlow closure devices improved the level of process control and processing time of blood component production with no negative effects on product quality. PMID:20529007

Device for measuring the fluid density of a two-phase mixture

DOEpatents

Cole, Jack H.

1980-01-01

A device for measuring the fluid density of a two-phase mixture flowing through a tubular member. A rotor assembly is rotatively supported within the tubular member so that it can also move axially within the tubular member. The rotor assembly is balanced against a pair of springs which exert an axial force in the opposite direction upon the rotor assembly. As a two-phase mixture flows through the tubular member it contacts the rotor assembly causing it to rotate about its axis. The rotor assembly is forced against and partially compresses the springs. Means are provided to measure the rotational speed of the rotor assembly and the linear displacement of the rotor assembly. From these measurements the fluid density of the two-phase mixture is calculated.

In vitro performance and principles of anti-siphoning devices.

PubMed

Freimann, Florian Baptist; Kimura, Takaoki; Stockhammer, Florian; Schulz, Matthias; Rohde, Veit; Thomale, Ulrich-Wilhelm

2014-11-01

Anti-siphon devices (ASDs) of various working principles were developed to overcome overdrainage-related complications associated with ventriculoperitoneal shunting. We aimed to provide comparative data on the pressure and flow characteristics of six different types of ASDs (gravity-assisted, membrane-controlled, and flow-regulated) in order to achieve a better understanding of these devices and their potential clinical application. We analyzed three gravity-dependent ASDs (ShuntAssistant [SA], Miethke; Gravity Compensating Accessory [GCA], Integra; SiphonX [SX], Sophysa), two membrane-controlled ASDs (Anti-Siphon Device [IASD], Integra; Delta Chamber [DC], Medtronic), and one flow-regulated ASD (SiphonGuard [SG], Codman). Defined pressure conditions within a simulated shunt system were generated (differential pressure 10-80 cmH2O), and the specific flow and pressure characteristics were measured. In addition, the gravity-dependent ASDs were measured in defined spatial positions (0-90°). The flow characteristics of the three gravity-assisted ASDs were largely dependent upon differential pressure and on their spatial position. All three devices were able to reduce the siphoning effect, but each to a different extent (flow at inflow pressure: 10 cmH2O, siphoning -20 cmH2O at 0°/90°: SA, 7.1 ± 1.2*/2.3 ±  0.5* ml/min; GCA, 10.5 ± 0.8/3.4 ± 0.4* ml/min; SX, 9.5 ± 1.2*/4.7 ± 1.9* ml/min, compared to control, 11.1 ± 0.4 ml/min [*p < 0.05]). The flow characteristics of the remaining ASDs were primarily dependent upon the inflow pressure effect (flow at 10 cmH2O, siphoning 0 cmH2O/ siphoning -20cmH2O: DC, 2.6 ± 0.1/ 4 ± 0.3* ml/min; IASD, 2.5 ± 0.2/ 0.8 ± 0.4* ml/min; SG, 0.8 ± 0.2*/ 0.2 ± 0.1* ml/min [*p < 0.05 vs. control, respectively]). The tested ASDs were able to control the siphoning effect within a simulated shunt system to differing degrees. Future comparative trials are needed to determine the type of device that is superior for clinical application.

Electrets used to measure exhaust cloud effluents from Solid Rocket Motor (SRM) during demonstration model (DM-2) static test firing

NASA Technical Reports Server (NTRS)

Susko, M.

1978-01-01

Electrets were compared with fixed flow samplers during static test firing. The measurement of the rocket exhaust effluents by samplers and electrets indicated that the Solid Rocket Motor had no significant effect on the air quality in the area sampled. The results show that the electrets (a passive device which needs no power) can be used effectively alongside existing measuring devices (which need power). By placing electrets in areas where no power is available, measurements may be obtained. Consequently, it is a valuable complementary instrument in measuring rocket exhaust effluents in areas where other measuring devices may not be able to assess the contaminants.

40 CFR 141.100 - Criteria and procedures for public water systems using point-of-entry devices.

Code of Federal Regulations, 2011 CFR

2011-07-01

... include physical measurements and observations such as total flow treated and mechanical condition of the... engineering design review of the point-of-entry devices. (2) The design and application of the point-of-entry...

40 CFR 141.100 - Criteria and procedures for public water systems using point-of-entry devices.

Code of Federal Regulations, 2013 CFR

2013-07-01

... include physical measurements and observations such as total flow treated and mechanical condition of the... engineering design review of the point-of-entry devices. (2) The design and application of the point-of-entry...

40 CFR 141.100 - Criteria and procedures for public water systems using point-of-entry devices.

Code of Federal Regulations, 2012 CFR

2012-07-01

... include physical measurements and observations such as total flow treated and mechanical condition of the... engineering design review of the point-of-entry devices. (2) The design and application of the point-of-entry...

Designing a Microfluidic Device with Integrated Ratiometric Oxygen Sensors for the Long-Term Control and Monitoring of Chronic and Cyclic Hypoxia

PubMed Central

Grist, Samantha M.; Schmok, Jonathan C.; Liu, Meng-Chi (Andy); Chrostowski, Lukas; Cheung, Karen C.

2015-01-01

Control of oxygen over cell cultures in vitro is a topic of considerable interest, as chronic and cyclic hypoxia can alter cell behaviour. Both static and transient hypoxic levels have been found to affect tumour cell behaviour; it is potentially valuable to include these effects in early, in vitro stages of drug screening. A barrier to their inclusion is that rates of transient hypoxia can be a few cycles/hour, which is difficult to reproduce in traditional in vitro cell culture environments due to long diffusion distances from control gases to the cells. We use a gas-permeable three-layer microfluidic device to achieve spatial and temporal oxygen control with biologically-relevant switching times. We measure the oxygen profiles with integrated, ratiometric optical oxygen sensors, demonstrate sensor and system stability over multi-day experiments, and characterize a pre-bleaching process to improve sensor stability. We show, with both finite-element modelling and experimental data, excellent control over the oxygen levels by the device, independent of fluid flow rate and oxygenation for the operating flow regime. We measure equilibration times of approximately 10 min, generate complex, time-varying oxygen profiles, and study the effects of oxygenated media flow rates on the measured oxygen levels. This device could form a useful tool for future long-term studies of cell behaviour under hypoxia. PMID:26287202

Utilization of microparticles in next-generation assays for microflow cytometers.

PubMed

Kim, Jason S; Ligler, Frances S

2010-11-01

Micron-sized particles have primarily been used in microfabricated flow cytometers for calibration purposes and proof-of-concept experiments. With increasing frequency, microparticles are serving as a platform for assays measured in these small analytical devices. Light scattering has been used to measure the agglomeration of antibody-coated particles in the presence of an antigen. Impedance detection is another technology being integrated into microflow cytometers for microparticle-based assays. Fluorescence is the most popular detection method in flow cytometry, enabling highly sensitive multiplexed assays. Finally, magnetic particles have also been used to measure antigen levels using a magnetophoretic micro-device. We review the progress of microparticle-based assays in microflow cytometry in terms of the advantages and limitations of each approach.

Optical Electronic Bragg Reflection Sensor System with Hydrodynamic Flow Applications

NASA Technical Reports Server (NTRS)

Lyons, D. R.

2003-01-01

This project, as described in the following report, involved design and fabrication of fiber optic sensors for the detection and measurement of dynamic fluid density variations. These devices are created using UV (ultraviolet) ablation and generally modified transverse holographic fiber grating techniques. The resulting phase gratings created on or immediately underneath the flat portion of D-shaped optical waveguides are characterized as evanescent field sensing devices. The primary applications include the sensor portion of a real-time localized or distributed measurement system for hydrodynamic flow, fluid density measurements, and phase change phenomena. Several design modifications were implemented in an attempt to accomplish the tasks specified in our original proposal. In addition, we have established key collaborative relationships with numerous people and institutions.

On the Use of the Platelet Activity State Assay for the In Vitro Quantification of Platelet Activation in Blood Recirculating Devices for Extracorporeal Circulation.

PubMed

Consolo, Filippo; Valerio, Lorenzo; Brizzola, Stefano; Rota, Paolo; Marazzato, Giulia; Vincoli, Valentina; Reggiani, Stefano; Redaelli, Alberto; Fiore, Gianfranco

2016-10-01

We designed an experimental setup to characterize the thrombogenic potential associated with blood recirculating devices (BRDs) used in extracorporeal circulation (ECC). Our methodology relies on in vitro flow loop platelet recirculation experiments combined with the modified-prothrombinase platelet activity state (PAS) assay to quantify the bulk thrombin production rate of circulated platelets, which correlates to the platelet activation (PA) level. The method was applied to a commercial neonatal hollow fiber membrane oxygenator. In analogous hemodynamic environment, we compared the PA level resulting from multiple passes of platelets within devices provided with phosphorylcholine (PC)-coated and noncoated (NC) fibers to account for flow-related mechanical factors (i.e., fluid-induced shear stress) together with surface contact activation phenomena. We report for the first time that PAS assay is not significantly sensitive to the effect of material coating under clinically pertinent flow conditions (500 mL/min), while providing straightforward information on shear-mediated PA dynamics in ECC devices. Being that the latter is intimately dependent on local flow dynamics, according to our results, the rate of thrombin production as measured by the PAS assay is a valuable biochemical marker of the selective contribution of PA in BRDs induced by device design features. Thus, we recommend the use of PAS assay as a means of evaluating the effect of modification of specific device geometrical features and/or different design solutions for developing ECC devices providing flow conditions with reduced thrombogenic impact. Copyright © 2016 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.

[Evaluation and Optimization of Microvascular Arterial Anastomoses by Transit Time Flow Measurement].

PubMed

Herberhold, S; Röttker, J; Bartmann, D; Solbach, A; Keiner, S; Welz, A; Bootz, F; Laffers, W

2016-03-01

INDRODUCTION: The regular application of transit time flow measurement in microvascular anastomoses during heart surgery has lead to improvements of the outcome of coronary artery bypass grafts. Our study was meant to discover whether this measurement method was also applicable for evaluation and optimization of microvascular arterial anastomoses of radial forearm flaps. In this prospective examination a combining ultrasound imaging and transit time flow measurement device (VeriQ, MediStim) was used during surgery to assess anastomotic quality of 15 radial forearm flaps. Pulsatility index (PI) and mean blood flow were measured immediately after opening the arterial anastomosis as well as 15 min afterwards. Furthermore, application time and description of handling were recorded seperately for every assessment. Mean blood flow immediately after opening the anastomosis and 15 min later were 3.9 and 3.4 ml/min resepectively showing no statistically significant difference (p=0.96). There was no significance in the increase of pulsatility index from 22.1 to 27.2 (p=0.09) during the same time range, either. Due to measurement results showing atypical pulse curves in 2 cases decision for surgical revision of the anastomoses was made. All forearm flaps showed good vascularisation during follow-up. Time for device set up, probe placement and measurements was about 20 min. Handling was described to be uncomplicated without exception. There were no noteworthy problems. Transit time flow measurement contributes to the improvement of anastomotic quality and therefore to the overall outcome of radial forearm flaps. The examined measurement method provides objective results and is useful for documentation purposes. © Georg Thieme Verlag KG Stuttgart · New York.

Microfluidic device capable of medium recirculation for non-adherent cell culture

PubMed Central

Dixon, Angela R.; Rajan, Shrinidhi; Kuo, Chuan-Hsien; Bersano, Tom; Wold, Rachel; Futai, Nobuyuki; Takayama, Shuichi; Mehta, Geeta

2014-01-01

We present a microfluidic device designed for maintenance and culture of non-adherent mammalian cells, which enables both recirculation and refreshing of medium, as well as easy harvesting of cells from the device. We demonstrate fabrication of a novel microfluidic device utilizing Braille perfusion for peristaltic fluid flow to enable switching between recirculation and refresh flow modes. Utilizing fluid flow simulations and the human promyelocytic leukemia cell line, HL-60, non-adherent cells, we demonstrate the utility of this RECIR-REFRESH device. With computer simulations, we profiled fluid flow and concentration gradients of autocrine factors and found that the geometry of the cell culture well plays a key role in cell entrapping and retaining autocrine and soluble factors. We subjected HL-60 cells, in the device, to a treatment regimen of 1.25% dimethylsulfoxide, every other day, to provoke differentiation and measured subsequent expression of CD11b on day 2 and day 4 and tumor necrosis factor-alpha (TNF-α) on day 4. Our findings display perfusion sensitive CD11b expression, but not TNF-α build-up, by day 4 of culture, with a 1:1 ratio of recirculation to refresh flow yielding the greatest increase in CD11b levels. RECIR-REFRESH facilitates programmable levels of cell differentiation in a HL-60 non-adherent cell population and can be expanded to other types of non-adherent cells such as hematopoietic stem cells. PMID:24753733

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bolenbaugh, Jonathan M.; Naqi, Syed

A method to operate a clutch device in an electro-mechanical transmission mechanically-operatively coupled to an internal combustion engine and at least one electric machine includes, in response to a failure condition detected within a flow control device configured to facilitate flow of hydraulic fluid for operating the clutch device, selectively preventing the flow of hydraulic fluid from entering the flow control device and feeding the clutch device. Synchronization of the clutch device is initiated when the clutch device is intended for activation, and only if the clutch device is synchronized, the flow of hydraulic fluid is selectively permitted to entermore » the flow control device to activate the clutch device.« less

RIGHT VENTRICULAR UNLOADING AND RESPIRATORY SUPPORT WITH A WEARABLE ARTIFICIAL PUMP-LUNG (APL) IN AN OVINE MODEL

PubMed Central

Liu, Yang; Sanchez, Pablo G; Wei, Xufeng; Li, Tieluo; Watkins, Amelia C; Li, Shu-ying; Griffith, Bartley P; Wu, Zhongjun J

2014-01-01

Background Device availability of mechanical circulatory or respiratory support to the right heart has been limited. The purpose of this study was to investigate the effect of right heart unloading and respiratory support with a wearable integrated artificial pump-lung (APL). Methods The APL device was placed surgically between the right atrium and pulmonary artery in seven sheep. Anticoagulation was performed with heparin infusion. Its ability to unload the right ventricle (RV) was investigated by echocardiograms and right heart catheterization at different bypass flow rates. Hemodynamics and Echo data were evaluated. The device flow and gas transfer rates were also measured at different device speeds. Results Hemodynamics remained stable during APL support. There was no significant change in systemic blood pressure and cardiac index. Central venous pressure, RV pressure, RV end-diastolic dimension and RV ejection fraction were significant decreased when APL device flow rate approached 2 L/min. The linear regression showed significant correlative trends between the hemodynamic and cardiac indices and the device speed. The oxygen transfer rate increased with the device speed. The oxygen saturation from APL outlet was fully saturated (>95%) during the support. The impact of the APL support on blood elements (plasma free hemoglobin and platelet activation) was minimal. Conclusion The APL device support significantly unloaded the right ventricle with increasing device speed. The APL device provided stable hemodynamic and respiratory support in terms of blood flow and oxygen transfer. The right heart unloading performance of this wearable device need to be evaluated in the animal model with right heart failure for a long term support. PMID:24746636

A Low-Power and Portable Biomedical Device for Respiratory Monitoring with a Stable Power Source

PubMed Central

Yang, Jiachen; Chen, Bobo; Zhou, Jianxiong; Lv, Zhihan

2015-01-01

Continuous respiratory monitoring is an important tool for clinical monitoring. Associated with the development of biomedical technology, it has become more and more important, especially in the measuring of gas flow and CO2 concentration, which can reflect the status of the patient. In this paper, a new type of biomedical device is presented, which uses low-power sensors with a piezoresistive silicon differential pressure sensor to measure gas flow and with a pyroelectric sensor to measure CO2 concentration simultaneously. For the portability of the biomedical device, the sensors and low-power measurement circuits are integrated together, and the airway tube also needs to be miniaturized. Circuits are designed to ensure the stability of the power source and to filter out the existing noise. Modulation technology is used to eliminate the fluctuations at the trough of the waveform of the CO2 concentration signal. Statistical analysis with the coefficient of variation was performed to find out the optimal driving voltage of the pressure transducer. Through targeted experiments, the biomedical device showed a high accuracy, with a measuring precision of 0.23 mmHg, and it worked continuously and stably, thus realizing the real-time monitoring of the status of patients. PMID:26270665

Performance of three systems for warming intravenous fluids at different flow rates.

PubMed

Satoh, J; Yamakage, M; Wasaki, S I; Namiki, A

2006-02-01

This study compared the intravenous fluid warming capabilities of three systems at different flow rates. The devices studied were a water-bath warmer, a dry-heat plate warmer, and an intravenous fluid tube warmer Ambient temperature was controlled at 22 degrees to 24 degrees C. Normal saline (0.9% NaCl) at either room temperature (21 degrees to 23 degrees C) or at ice-cold temperature (3 degrees to 5 degrees C) was administered through each device at a range of flow rates (2 to 100 ml/min). To mimic clinical conditions, the temperature of the fluid was measured with thermocouples at the end of a one metre tube connected to the outflow of the warmer for the first two devices and at the end of the 1.2 m warming tubing for the intravenous fluid tube warmer The temperature of fluid delivered by the water bath warmer increased as the flow rate was increased up to 15 to 20 ml/min but decreased with greater flow rates. The temperature of the fluid delivered by the dry-heat plate warmer significantly increased as the flow rate was increased within the range tested (due to decreased cooling after leaving the device at higher flow rates). The temperature of fluid delivered by the intravenous fluid tube warmer did not depend on the flow rate up to 20 ml/min but significantly and fluid temperature-dependently decreased at higher flow rates (>30 ml/min). Under the conditions of our testing, the dry heat plate warmer delivered the highest temperature fluid at high flow rates.

Analysis of the separated boundary layer flow on the surface and in the wake of blunt trailing edge airfoils

NASA Technical Reports Server (NTRS)

Goradia, S. H.; Mehta, J. M.; Shrewsbury, G. S.

1977-01-01

The viscous flow phenomena associated with sharp and blunt trailing edge airfoils were investigated. Experimental measurements were obtained for a 17 percent thick, high performance GAW-1 airfoil. Experimental measurements consist of velocity and static pressure profiles which were obtained by the use of forward and reverse total pressure probes and disc type static pressure probes over the surface and in the wake of sharp and blunt trailing edge airfoils. Measurements of the upper surface boundary layer were obtained in both the attached and separated flow regions. In addition, static pressure data were acquired, and skin friction on the airfoil upper surface was measured with a specially constructed device. Comparison of the viscous flow data with data previously obtained elsewhere indicates reasonable agreement in the attached flow region. In the separated flow region, considerable differences exist between these two sets of measurements.

FDA Benchmark Medical Device Flow Models for CFD Validation.

PubMed

Malinauskas, Richard A; Hariharan, Prasanna; Day, Steven W; Herbertson, Luke H; Buesen, Martin; Steinseifer, Ulrich; Aycock, Kenneth I; Good, Bryan C; Deutsch, Steven; Manning, Keefe B; Craven, Brent A

Computational fluid dynamics (CFD) is increasingly being used to develop blood-contacting medical devices. However, the lack of standardized methods for validating CFD simulations and blood damage predictions limits its use in the safety evaluation of devices. Through a U.S. Food and Drug Administration (FDA) initiative, two benchmark models of typical device flow geometries (nozzle and centrifugal blood pump) were tested in multiple laboratories to provide experimental velocities, pressures, and hemolysis data to support CFD validation. In addition, computational simulations were performed by more than 20 independent groups to assess current CFD techniques. The primary goal of this article is to summarize the FDA initiative and to report recent findings from the benchmark blood pump model study. Discrepancies between CFD predicted velocities and those measured using particle image velocimetry most often occurred in regions of flow separation (e.g., downstream of the nozzle throat, and in the pump exit diffuser). For the six pump test conditions, 57% of the CFD predictions of pressure head were within one standard deviation of the mean measured values. Notably, only 37% of all CFD submissions contained hemolysis predictions. This project aided in the development of an FDA Guidance Document on factors to consider when reporting computational studies in medical device regulatory submissions. There is an accompanying podcast available for this article. Please visit the journal's Web site (www.asaiojournal.com) to listen.

[Validation of a new hand-carried ultrasound device equipped with directional color power Doppler and continuous wave Doppler].

PubMed

Kawai, Junichi; Tanabe, Kazuaki; Matsuzaki, Masashi; Yamaguchi, Kazuto; Yagi, Toshikazu; Fujii, Yoko; Konda, Toshiko; Ui, Kazuyo; Sumida, Toshiaki; Okada, Midori; Tani, Tomoko; Morioka, Shigefumi

2003-10-01

This study evaluated the accuracy of the directional color power Doppler (DCPD) and continuous wave Doppler (CWD) methods incorporated in the new hand-carried SonoSite 180PLUS ultrasound device. The hand-held ultrasound system with 2.5 MHz transducer and SONOS 5500 was used as a standard ultrasound system with a 2 to 4 MHz wideband transducer. The experimental study used a Doppler wire phantom to evaluate the influence of target wire speed and angle of transducer on DCPD imaging. The clinical study included 48 consecutive patients. DCPD assessment of valvular regurgitation measured the distances of DCPD signals of mitral, aortic and tricuspid valve regurgitation using the apical four-chamber view for comparison with standard echocardiography. CWD assessment measured the peak velocities of the aortic flow and tricuspid valve regurgitant flow for comparison with standard echocardiography. In the experimental study, DCPD signals were not influenced by target wire speed changes and transducer incident angles. In the clinical study, agreements for mitral, aortic and tricuspid regurgitation between the two methods were 89.6%, 81.8% and 78.7%, respectively. The distances of DCPD valve regurgitant signals by the hand-carried ultrasound device showed good correlation (mitral regurgitation: y = 0.84x + 0.55; r = 0.93, aortic regurgitation: y = 0.95x + 0.27; r = 0.94, tricuspid regurgitation: y = 0.86x + 0.61; r = 0.90) with those by standard echocardiography. Evaluation of CWD velocity measurements showed good agreement for the lower flow velocities (< 2.0 m/sec). However, underestimation occurred for the high flow velocities (> 2.0 m/sec) compared with those by standard echocardiography (aortic flow: y = 0.80x + 0.11; r = 0.95, tricuspid regurgitation: y = 1.00x - 0.23; r = 0.90). The new hand-carried ultrasound device (SonoSite 180PLUS equipped with DCPD and CWD) is clinically useful for evaluating valvular regurgitations and flow velocities. Further studies are needed to determine the mechanism of the underestimation of high flow velocities by CWD.

Development of a new control device for stabilizing blood level in reservoir during extracorporeal circulation.

PubMed

Momose, Naoki; Yamakoshi, Rie; Kokubo, Ryo; Yasuda, Toru; Iwamoto, Norio; Umeda, Chinori; Nakajima, Itsuro; Yanagisawa, Mitsunobu; Tomizawa, Yasuko

2010-03-01

We developed a simple device that stabilizes the blood level in the reservoir of the extracorporeal circulation open circuit system by measuring the hydrostatic pressure of the reservoir to control the flow rate of the arterial pump. When the flow rate of the venous return decreases, the rotation speed of the arterial pump is automatically slowed down. Consequently, the blood level in the reservoir is stabilized quickly between two arbitrarily set levels and never falls below the pre-set low level. We conducted a basic experiment to verify the operation of the device, using a mock circuit with water. Commercially available pumps and reservoir were used without modification. The results confirmed that the control method effectively regulates the reservoir liquid level and is highly reliable. The device possibly also functions as a safety device.

Computer assisted uroflowmetry diagnostic system

NASA Astrophysics Data System (ADS)

Makal, Jarosław; Idźkowski, Adam; Walendziuk, Wojciech

2006-10-01

In this paper an original uroflowmeter (called Adalbertus) has been presented. The device draws the flow chart and measures the parameters of urine flow. It is used in urological surgeries as an assistance in diagnosis of lower urinary track diseases like Benign Prostatic Hyperplasia (BPH). The measuring track and its main part - weight sensor have been described. Also the way of uncertainty calculation is mentioned. An example flow chart has been shown and the achieved results have been compared with a commercial product.

Enhanced water vapour flow in silica microchannels and interdiffusive water vapour flow through anodic aluminium oxide (AAO) membranes

NASA Astrophysics Data System (ADS)

Lei, Wenwen; McKenzie, David R.

2015-12-01

Enhanced liquid water flows through carbon nanotubes reinvigorated the study of moisture permeation through membranes and micro- and nano-channels. The study of water vapour through micro-and nano-channels has been neglected even though water vapour is as important as liquid water for industry, especially for encapsulation of electronic devices. Here we measure moisture flow rates in silica microchannels and interdiffusive water vapour flows in anodic aluminium oxide (AAO) membrane channels for the first time. We construct theory for the flow rates of the dominant modes of water transport through four previously defined standard configurations and benchmark it against our new measurements. The findings show that measurements of leak behaviour made using other molecules, such as helium, are not reliable. Single phase water vapour flow is overestimated by a helium measurement, while Washburn or capillary flow is underestimated or for all channels when boundary slip applies, to an extent that depends on the slip length for the liquid phase flows.

Evaluation of commercially available techniques and development of simplified methods for measuring grille airflows in HVAC systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Walker, Iain S.; Wray, Craig P.; Guillot, Cyril

2003-08-01

In this report, we discuss the accuracy of flow hoods for residential applications, based on laboratory tests and field studies. The results indicate that commercially available hoods are often inadequate to measure flows in residential systems, and that there can be a wide range of performance between different flow hoods. The errors are due to poor calibrations, sensitivity of existing hoods to grille flow non-uniformities, and flow changes from added flow resistance. We also evaluated several simple techniques for measuring register airflows that could be adopted by the HVAC industry and homeowners as simple diagnostics that are often as accuratemore » as commercially available devices. Our test results also show that current calibration procedures for flow hoods do not account for field application problems. As a result, organizations such as ASHRAE or ASTM need to develop a new standard for flow hood calibration, along with a new measurement standard to address field use of flow hoods.« less

40 CFR 86.1343-88 - Calculations; particulate exhaust emissions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... depressions below atmospheric measured at the inlet to the positive displacement pump (during an idle mode...)(5). (8)(i) Real time flow rate measurement and calculating devices are permitted under these...

40 CFR 86.1343-88 - Calculations; particulate exhaust emissions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... depressions below atmospheric measured at the inlet to the positive displacement pump (during an idle mode...)(5). (8)(i) Real time flow rate measurement and calculating devices are permitted under these...

A novel anthropomorphic flow phantom for the quantitative evaluation of prostate DCE-MRI acquisition techniques

NASA Astrophysics Data System (ADS)

Knight, Silvin P.; Browne, Jacinta E.; Meaney, James F.; Smith, David S.; Fagan, Andrew J.

2016-10-01

A novel anthropomorphic flow phantom device has been developed, which can be used for quantitatively assessing the ability of magnetic resonance imaging (MRI) scanners to accurately measure signal/concentration time-intensity curves (CTCs) associated with dynamic contrast-enhanced (DCE) MRI. Modelling of the complex pharmacokinetics of contrast agents as they perfuse through the tumour capillary network has shown great promise for cancer diagnosis and therapy monitoring. However, clinical adoption has been hindered by methodological problems, resulting in a lack of consensus regarding the most appropriate acquisition and modelling methodology to use and a consequent wide discrepancy in published data. A heretofore overlooked source of such discrepancy may arise from measurement errors of tumour CTCs deriving from the imaging pulse sequence itself, while the effects on the fidelity of CTC measurement of using rapidly-accelerated sequences such as parallel imaging and compressed sensing remain unknown. The present work aimed to investigate these features by developing a test device in which ‘ground truth’ CTCs were generated and presented to the MRI scanner for measurement, thereby allowing for an assessment of the DCE-MRI protocol to accurately measure this curve shape. The device comprised a four-pump flow system wherein CTCs derived from prior patient prostate data were produced in measurement chambers placed within the imaged volume. The ground truth was determined as the mean of repeat measurements using an MRI-independent, custom-built optical imaging system. In DCE-MRI experiments, significant discrepancies between the ground truth and measured CTCs were found for both tumorous and healthy tissue-mimicking curve shapes. Pharmacokinetic modelling revealed errors in measured K trans, v e and k ep values of up to 42%, 31%, and 50% respectively, following a simple variation of the parallel imaging factor and number of signal averages in the acquisition protocol. The device allows for the quantitative assessment and standardisation of DCE-MRI protocols (both existing and emerging).

Model of Pressure Distribution in Vortex Flow Controls

NASA Astrophysics Data System (ADS)

Mielczarek, Szymon; Sawicki, Jerzy M.

2015-06-01

Vortex valves belong to the category of hydrodynamic flow controls. They are important and theoretically interesting devices, so complex from hydraulic point of view, that probably for this reason none rational concept of their operation has been proposed so far. In consequence, functioning of vortex valves is described by CFD-methods (computer-aided simulation of technical objects) or by means of simple empirical relations (using discharge coefficient or hydraulic loss coefficient). Such rational model of the considered device is proposed in the paper. It has a simple algebraic form, but is well grounded physically. The basic quantitative relationship, which describes the valve operation, i.e. dependence between the flow discharge and the circumferential pressure head, caused by the rotation, has been verified empirically. Conformity between calculated and measured parameters of the device allows for acceptation of the proposed concept.

Time-Resolved Particle Image Velocimetry Measurements with Wall Shear Stress and Uncertainty Quantification for the FDA Nozzle Model.

PubMed

Raben, Jaime S; Hariharan, Prasanna; Robinson, Ronald; Malinauskas, Richard; Vlachos, Pavlos P

2016-03-01

We present advanced particle image velocimetry (PIV) processing, post-processing, and uncertainty estimation techniques to support the validation of computational fluid dynamics analyses of medical devices. This work is an extension of a previous FDA-sponsored multi-laboratory study, which used a medical device mimicking geometry referred to as the FDA benchmark nozzle model. Experimental measurements were performed using time-resolved PIV at five overlapping regions of the model for Reynolds numbers in the nozzle throat of 500, 2000, 5000, and 8000. Images included a twofold increase in spatial resolution in comparison to the previous study. Data was processed using ensemble correlation, dynamic range enhancement, and phase correlations to increase signal-to-noise ratios and measurement accuracy, and to resolve flow regions with large velocity ranges and gradients, which is typical of many blood-contacting medical devices. Parameters relevant to device safety, including shear stress at the wall and in bulk flow, were computed using radial basis functions. In addition, in-field spatially resolved pressure distributions, Reynolds stresses, and energy dissipation rates were computed from PIV measurements. Velocity measurement uncertainty was estimated directly from the PIV correlation plane, and uncertainty analysis for wall shear stress at each measurement location was performed using a Monte Carlo model. Local velocity uncertainty varied greatly and depended largely on local conditions such as particle seeding, velocity gradients, and particle displacements. Uncertainty in low velocity regions in the sudden expansion section of the nozzle was greatly reduced by over an order of magnitude when dynamic range enhancement was applied. Wall shear stress uncertainty was dominated by uncertainty contributions from velocity estimations, which were shown to account for 90-99% of the total uncertainty. This study provides advancements in the PIV processing methodologies over the previous work through increased PIV image resolution, use of robust image processing algorithms for near-wall velocity measurements and wall shear stress calculations, and uncertainty analyses for both velocity and wall shear stress measurements. The velocity and shear stress analysis, with spatially distributed uncertainty estimates, highlights the challenges of flow quantification in medical devices and provides potential methods to overcome such challenges.

NEUTRONIC REACTOR CORE INSTRUMENT

DOEpatents

Mims, L.S.

1961-08-22

A multi-purpose instrument for measuring neutron flux, coolant flow rate, and coolant temperature in a nuclear reactor is described. The device consists essentially of a hollow thimble containing a heat conducting element protruding from the inner wall, the element containing on its innermost end an amount of fissionsble materinl to function as a heat source when subjected to neutron flux irradiation. Thermocouple type temperature sensing means are placed on the heat conducting element adjacent the fissionable material and at a point spaced therefrom, and at a point on the thimble which is in contact with the coolant fluid. The temperature differentials measured between the thermocouples are determinative of the neutron flux, coolant flow, and temperature being measured. The device may be utilized as a probe or may be incorporated in a reactor core. (AE C)

Effect of Sub-Boundary Layer Vortex Generations on Incident Turbulence

NASA Technical Reports Server (NTRS)

Casper, J.; Lin, J. C.; Yao, C. S.

2003-01-01

Sub-boundary layer vortex generators were tested in a wind tunnel to assess their effect on the velocity field within the wake region of a turbulent boundary layer. Both mean flow quantities and turbulence statistics were measured. Although very small relative to the boundary layer thickness, these so-called micro vortex generators were found to have a measurable effect on the power spectra and integral length scales of the turbulence at a distance many times the height of the devices themselves. In addition, the potential acoustic impact of these devices is also discussed. Measured turbulence spectra are used as input to an acoustic formulation in a manner that compares predicted sound pressure levels that result from the incident boundary-layer turbulence, with and without the vortex generators in the flow.

Measuring Time-Averaged Blood Pressure

NASA Technical Reports Server (NTRS)

Rothman, Neil S.

1988-01-01

Device measures time-averaged component of absolute blood pressure in artery. Includes compliant cuff around artery and external monitoring unit. Ceramic construction in monitoring unit suppresses ebb and flow of pressure-transmitting fluid in sensor chamber. Transducer measures only static component of blood pressure.

Electric Current Flow Through Two-Dimensional Networks

NASA Astrophysics Data System (ADS)

Gaspard, Mallory

In modern nanotechnology, two-dimensional atomic network structures boast promising applications as nanoscale circuit boards to serve as the building blocks of more sustainable and efficient, electronic devices. However, properties associated with the network connectivity can be beneficial or deleterious to the current flow. Taking a computational approach, we will study large uniform networks, as well as large random networks using Kirchhoff's Equations in conjunction with graph theoretical measures of network connectedness and flows, to understand how network connectivity affects overall ability for successful current flow throughout a network. By understanding how connectedness affects flow, we may develop new ways to design more efficient two-dimensional materials for the next generation of nanoscale electronic devices, and we will gain a deeper insight into the intricate balance between order and chaos in the universe. Rensselaer Polytechnic Institute, SURP Institutional Grant.

Microparticle analysis system and method

NASA Technical Reports Server (NTRS)

Morrison, Dennis R. (Inventor)

2007-01-01

A device for analyzing microparticles is provided which includes a chamber with an inlet and an outlet for respectively introducing and dispensing a flowing fluid comprising microparticles, a light source for providing light through the chamber and a photometer for measuring the intensity of light transmitted through individual microparticles. The device further includes an imaging system for acquiring images of the fluid. In some cases, the device may be configured to identify and determine a quantity of the microparticles within the fluid. Consequently, a method for identifying and tracking microparticles in motion is contemplated herein. The method involves flowing a fluid comprising microparticles in laminar motion through a chamber, transmitting light through the fluid, measuring the intensities of the light transmitted through the microparticles, imaging the fluid a plurality of times and comparing at least some of the intensities of light between different images of the fluid.

Experimental and numerical investigation of HyperVapotron heat transfer

NASA Astrophysics Data System (ADS)

Wang, Weihua; Deng, Haifei; Huang, Shenghong; Chu, Delin; Yang, Bin; Mei, Luoqin; Pan, Baoguo

2014-12-01

The divertor first wall and neutral beam injection (NBI) components of tokamak devices require high heat flux removal up to 20-30 MW m-2 for future fusion reactors. The water cooled HyperVapotron (HV) structure, which relies on internal grooves or fins and boiling heat transfer to maximize the heat transfer capability, is the most promising candidate. The HV devices, that are able to transfer large amounts of heat (1-20 MW m-2) efficiently, have therefore been developed specifically for this application. Until recently, there have been few attempts to observe the detailed bubble characteristics and vortex evolvement of coolant flowing inside their various parts and understand of the internal two-phase complex heat transfer mechanism behind the vapotron effect. This research builds the experimental facilities of HyperVapotron Loop-I (HVL-I) and Pressure Water HyperVapotron Loop-II (PWHL-II) to implement the subcooled boiling principle experiment in terms of typical flow parameters, geometrical parameters of test section and surface heat flux, which are similar to those of the ITER-like first wall and NBI components (EAST and MAST). The multiphase flow and heat transfer phenomena on the surface of grooves and triangular fins when the subcooled water flowed through were observed and measured with the planar laser induced fluorescence (PLIF) and high-speed photography (HSP) techniques. Particle image velocimetry (PIV) was selected to reveal vortex formation, the flow structure that promotes the vapotron effect during subcooled boiling. The coolant flow data for contributing to the understanding of the vapotron phenomenon and the assessment of how the design and operational conditions that might affect the thermal performance of the devices were collected and analysed. The subcooled flow boiling model and methods of HV heat transfer adopted in the considered computational fluid dynamics (CFD) code were evaluated by comparing the calculated wall temperatures with the experimentally measured values. It was discovered that the bubble and vortex characteristics in the HV are clearly heavily dependent on the internal geometry, flow conditions and input heat flux. The evaporation latent heat is the primary heat transfer mechanism of HV flow under the condition of high heat flux, and the heat transfer through convection is very limited. The percentage of wall heat flux going into vapour production is almost 70%. These relationships between the flow phenomena and thermal performance of the HV device are essential to study the mechanisms for the flow structure alterations for design optimization and improvements of the ITER-like devices' water cooling structure and plasma facing components for future fusion reactors.

An optical manometer-on-a-chip

NASA Astrophysics Data System (ADS)

Jin, Yuhang; Crozier, Kenneth B.

2011-10-01

The rapid development of microfluidic devices in recent years has led to a huge number of applications in chemistry, biology and interdisciplinary areas. This is because they act as miniaturized platforms in which sorting, mixing, reaction and measurement can be achieved in a precise and rapid manner. Being able to both understand and measure the pressure of fluids inside these devices is very important, especially in the cases where multiphase flows are involved. For example, certain advanced micromixing technologies demand accurate evaluations of bubble-induced extra pressure, since the pressure contribution from one bubble is likely to impact the velocity and residence time of others, affecting the mixing efficiency and quality in a complicated manner. Similarly, in some microfluidics-based biochemical analysis, extra pressure brought about by droplets is a critical factor in the design of on-chip pumping, as high throughput experiments involving continuous supply of large numbers of droplets often require a considerable enhancement in the pumping pressure necessary to maintain the droplet flow3. Last, state-of-the-art microfluidic logic devices rely heavily on the pressure distribution inside the channels, which automatically controls the paths of each droplet in the microfluidic network and as a result determines the "on" and "off" of each switch. A few techniques to measure pressure change or pressure drop in microfluidic channels have been developed. Examples include connecting the device to commercially available pressure sensors and comparing pressures of different areas by analyzing the position of fluid-fluid interface. However, all of those methods have intrinsic drawbacks in one or more aspects that considerably limit their applications. A significant one is that they are primarily aiming at measuring or comparing pressures over relatively long channels (~10 mm), and are hence only designed to work in the highpressure range, i.e. to detect a pressure change on the order of tens or hundreds of Pascals. Moreover, the long channels make it rather challenging to look into the detailed dynamics of pressure variations caused by inhomogeneous emulsions, since such a long section invariably contains multiple elements, for instance droplets, of the emulsion flow, and the measurements average out the behavior of one single element. Consequently, to further reveal the characteristics of flows in microfluidics, it is highly desirable for a pressure measurement device to work in the low-pressure range, and to resolve pressure changes "locally", i.e. within small spatial regions.

40 CFR 60.384 - Monitoring of operations.

Code of Federal Regulations, 2010 CFR

2010-07-01

... wet scrubbing emission control device. The monitoring device must be certified by the manufacturer to be accurate within ±250 pascals (±1 inch water) gauge pressure and must be calibrated on an annual... continuous measurement of the scrubbing liquid flow rate to a wet scrubber for any affected facility using...

40 CFR 60.384 - Monitoring of operations.

Code of Federal Regulations, 2011 CFR

2011-07-01

... wet scrubbing emission control device. The monitoring device must be certified by the manufacturer to be accurate within ±250 pascals (±1 inch water) gauge pressure and must be calibrated on an annual... continuous measurement of the scrubbing liquid flow rate to a wet scrubber for any affected facility using...

40 CFR 60.384 - Monitoring of operations.

Code of Federal Regulations, 2012 CFR

2012-07-01

... wet scrubbing emission control device. The monitoring device must be certified by the manufacturer to be accurate within ±250 pascals (±1 inch water) gauge pressure and must be calibrated on an annual... continuous measurement of the scrubbing liquid flow rate to a wet scrubber for any affected facility using...

40 CFR 60.384 - Monitoring of operations.

Code of Federal Regulations, 2014 CFR

2014-07-01

... wet scrubbing emission control device. The monitoring device must be certified by the manufacturer to be accurate within ±250 pascals (±1 inch water) gauge pressure and must be calibrated on an annual... continuous measurement of the scrubbing liquid flow rate to a wet scrubber for any affected facility using...

40 CFR 60.384 - Monitoring of operations.

Code of Federal Regulations, 2013 CFR

2013-07-01

... wet scrubbing emission control device. The monitoring device must be certified by the manufacturer to be accurate within ±250 pascals (±1 inch water) gauge pressure and must be calibrated on an annual... continuous measurement of the scrubbing liquid flow rate to a wet scrubber for any affected facility using...

DEVELOPMENT OF A PROPORTIONAL SAMPLER FOR AUTOMOBILE EXHAUST EMISSIONS TESTING

EPA Science Inventory

The report describes the development of a device that is capable of sampling gaseous emissions from automobiles. The device samples exhaust gases at a mass rate that is proportional to the total exhaust gas mass flow rate, which is measured using an ultrasonic vortex flowmeter. T...

Development of core ion temperature gradients and edge sheared flows in a helicon plasma device investigated by laser induced fluorescence measurements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thakur, S. C.; Tynan, G. R.; Center for Energy Research, University of California at San Diego, San Diego, California 92093

2016-08-15

We report experimental observation of ion heating and subsequent development of a prominent ion temperature gradient in the core of a linear magnetized plasma device, and the controlled shear de-correlation experiment. Simultaneously, we also observe the development of strong sheared flows at the edge of the device. Both the ion temperature and the azimuthal velocity profiles are quite flat at low magnetic fields. As the magnetic field is increased, the core ion temperature increases, producing centrally peaked ion temperature profiles and therefore strong radial gradients in the ion temperature. Similarly, we observe the development of large azimuthal flows at themore » edge, with increasing magnetic field, leading to strong radially sheared plasma flows. The ion velocities and temperatures are derived from laser induced fluorescence measurements of Doppler resolved velocity distribution functions of argon ions. These features are consistent with the previous observations of simultaneously existing radially separated multiple plasma instabilities that exhibit complex plasma dynamics in a very simple plasma system. The ion temperature gradients in the core and the radially sheared azimuthal velocities at the edge point to mechanisms that can drive the multiple plasma instabilities, that were reported earlier.« less

Comparison of fluid dynamic numerical models for a clinical ventricular assist device and experimental validation

PubMed Central

Zhang, Jiafeng; Zhang, Pei; Fraser, Katharine H.; Griffith, Bartley P.; Wu, Zhongjun J.

2012-01-01

With the recent advances in computer technology, computational fluid dynamics (CFD) has become an important tool to design and improve blood contacting artificial organs, and to study the device-induced blood damage. Commercial CFD software packages are readily available, and multiple CFD models are provided by CFD software developers. However, the best approach of using CFD effectively to characterize fluid flow and to predict blood damage in these medical devices remains debatable. This study aimed to compare these CFD models and provide useful information on the accuracy of each model in modeling blood flow in circulatory assist devices. The laminar and five turbulence models (Spalart-Allmaras, k-ε (k-epsilon), k-ω (k-omega), SST (Menter’s Shear Stress Transport), and Reynolds Stress) were implemented to predict blood flow in a clinically used circulatory assist device, CentriMag® centrifugal blood pump (Thoratec, MA). In parallel, a transparent replica of the CentriMag® pump was constructed and selected views of the flow fields were measured with digital particle image velocimetry (DPIV). CFD results were compared with the DPIV experimental results. Compared with the experiment, all the selected CFD models predicted the flow pattern fairly well except the area of the outlet. However, quantitatively, the laminar model results were the most deviated from the experimental data. On the other hand, k-ε RNG models and Reynolds Stress model are the most accurate. In conclusion, for the circulatory assist devices, turbulence models provide more accurate results than laminar model. Among the selected turbulence models, k-ε and Reynolds Stress Method models are recommended. PMID:23441681

Humidification performance of two high-flow nasal cannula devices: a bench study.

PubMed

Chikata, Yusuke; Izawa, Masayo; Okuda, Nao; Itagaki, Taiga; Nakataki, Emiko; Onodera, Mutsuo; Imanaka, Hideaki; Nishimura, Masaji

2014-08-01

Delivering heated and humidified medical gas at 20-60 L/min, high-flow nasal cannula (HFNC) creates low levels of PEEP and ameliorates respiratory mechanics. It has become a common therapy for patients with respiratory failure. However, independent measurement of heat and humidity during HFNC and comparison of HFNC devices are lacking. We evaluated 2 HFNC (Airvo 2 and Optiflow system) devices. Each HFNC was connected to simulated external nares using the manufacturer's standard circuit. The Airvo 2 outlet-chamber temperature was set at 37°C. The Optiflow system incorporated an O2/air blender and a heated humidifier, which was set at 40°C/3. For both systems, HFNC flow was tested at 20, 40, and 50 L/min. Simulating spontaneous breathing using a mechanical ventilator and TTL test lung, we tested tidal volumes (VT) of 300, 500, and 700 mL, and breathing frequencies of 10 and 20 breaths/min. The TTL was connected to the simulated external nares with a standard ventilator circuit. To prevent condensation, the circuit was placed in an incubator maintained at 37°C. Small, medium, and large nasal prongs were tested. Absolute humidity (AH) of inspired gas was measured at the simulated external nares. At 20, 40, and 50 L/min of flow, respective AH values for the Airvo 2 were 35.3 ± 2.0, 37.1 ± 2.2, and 37.6 ± 2.1 mg/L, and for the Optiflow system, 33.1 ± 1.5, 35.9 ± 1.7, and 36.2 ± 1.8 mg/L. AH was lower at 20 L/min of HFNC flow than at 40 and 50 L/min (P < .01). While AH remained constant at 40 and 50 L/min, at 20 L/min of HFNC flow, AH decreased as VT increased for both devices. During bench use of HFNC, AH increased with increasing HFNC flow. When the inspiratory flow of spontaneous breathing exceeded the HFNC flow, AH was influenced by VT. At all experimental settings, AH remained > 30 mg/L.

Restoration of Pulsatile Flow Reduces Sympathetic Nerve Activity Among Individuals With Continuous-Flow Left Ventricular Assist Devices.

PubMed

Cornwell, William K; Tarumi, Takashi; Stickford, Abigail; Lawley, Justin; Roberts, Monique; Parker, Rosemary; Fitzsimmons, Catherine; Kibe, Julius; Ayers, Colby; Markham, David; Drazner, Mark H; Fu, Qi; Levine, Benjamin D

2015-12-15

Current-generation left ventricular assist devices provide circulatory support that is minimally or entirely nonpulsatile and are associated with marked increases in muscle sympathetic nerve activity (MSNA), likely through a baroreceptor-mediated pathway. We sought to determine whether the restoration of pulsatile flow through modulations in pump speed would reduce MSNA through the arterial baroreceptor reflex. Ten men and 3 women (54 ± 14 years) with Heartmate II continuous-flow left ventricular assist devices underwent hemodynamic and sympathetic neural assessment. Beat-to-beat blood pressure, carotid ultrasonography at the level of the arterial baroreceptors, and MSNA via microneurography were continuously recorded to determine steady-state responses to step changes (200-400 revolutions per minute) in continuous-flow left ventricular assist device pump speed from a maximum of 10,480 ± 315 revolutions per minute to a minimum of 8500 ± 380 revolutions per minute. Reductions in pump speed led to increases in pulse pressure (high versus low speed: 17 ± 7 versus 26 ± 12 mm Hg; P<0.01), distension of the carotid artery, and carotid arterial wall tension (P<0.05 for all measures). In addition, MSNA was reduced (high versus low speed: 41 ± 15 versus 33 ± 16 bursts per minute; P<0.01) despite a reduction in mean arterial pressure and was inversely related to pulse pressure (P=0.037). Among subjects with continuous-flow left ventricular assist devices, the restoration of pulsatile flow through modulations in pump speed leads to increased distortion of the arterial baroreceptors with a subsequent decline in MSNA. Additional study is needed to determine whether reduction of MSNA in this setting leads to improved outcomes. © 2015 American Heart Association, Inc.

Refinement of current monitoring methodology for electroosmotic flow assessment under low ionic strength conditions

PubMed Central

Saucedo-Espinosa, Mario A.; Lapizco-Encinas, Blanca H.

2016-01-01

Current monitoring is a well-established technique for the characterization of electroosmotic (EO) flow in microfluidic devices. This method relies on monitoring the time response of the electric current when a test buffer solution is displaced by an auxiliary solution using EO flow. In this scheme, each solution has a different ionic concentration (and electric conductivity). The difference in the ionic concentration of the two solutions defines the dynamic time response of the electric current and, hence, the current signal to be measured: larger concentration differences result in larger measurable signals. A small concentration difference is needed, however, to avoid dispersion at the interface between the two solutions, which can result in undesired pressure-driven flow that conflicts with the EO flow. Additional challenges arise as the conductivity of the test solution decreases, leading to a reduced electric current signal that may be masked by noise during the measuring process, making for a difficult estimation of an accurate EO mobility. This contribution presents a new scheme for current monitoring that employs multiple channels arranged in parallel, producing an increase in the signal-to-noise ratio of the electric current to be measured and increasing the estimation accuracy. The use of this parallel approach is particularly useful in the estimation of the EO mobility in systems where low conductivity mediums are required, such as insulator based dielectrophoresis devices. PMID:27375813

Microelectrical Impedance Spectroscopy for the Differentiation between Normal and Cancerous Human Urothelial Cell Lines: Real-Time Electrical Impedance Measurement at an Optimal Frequency

PubMed Central

Park, Yangkyu; Kim, Hyeon Woo; Yun, Joho; Seo, Seungwan; Park, Chang-Ju; Lee, Jeong Zoo; Lee, Jong-Hyun

2016-01-01

Purpose. To distinguish between normal (SV-HUC-1) and cancerous (TCCSUP) human urothelial cell lines using microelectrical impedance spectroscopy (μEIS). Materials and Methods. Two types of μEIS devices were designed and used in combination to measure the impedance of SV-HUC-1 and TCCSUP cells flowing through the channels of the devices. The first device (μEIS-OF) was designed to determine the optimal frequency at which the impedance of two cell lines is most distinguishable. The μEIS-OF trapped the flowing cells and measured their impedance at a frequency ranging from 5 kHz to 1 MHz. The second device (μEIS-RT) was designed for real-time impedance measurement of the cells at the optimal frequency. The impedance was measured instantaneously as the cells passed the sensing electrodes of μEIS-RT. Results. The optimal frequency, which maximized the average difference of the amplitude and phase angle between the two cell lines (p < 0.001), was determined to be 119 kHz. The real-time impedance of the cell lines was measured at 119 kHz; the two cell lines differed significantly in terms of amplitude and phase angle (p < 0.001). Conclusion. The μEIS-RT can discriminate SV-HUC-1 and TCCSUP cells by measuring the impedance at the optimal frequency determined by the μEIS-OF. PMID:26998490

Infrared Imaging Of Flows Seeded With SF6

NASA Technical Reports Server (NTRS)

Manuel, Gregory S.; Daryabeigi, Kamran; Alderfer, David W.; Obara, Clifford J.

1993-01-01

Novel technique enables repeated measurements of flow patterns during flight. Wing-tip vorticity studied in flight by observing infrared emissions from SF6 gas entrained in wing-tip flow. System makes vortical flows visible throughout all altitude and speed ranges of all subsonic aircraft. Also useful for transonic and supersonic speeds. Primary application is testing of aircraft in flight, also proves useful in testing fast land vehicles and structures or devices subject to strong winds.

EXTRACORPOREAL MEMBRANE OXYGENATION vs. COUNTERPULSATILE, PULSATILE, AND CONTINUOUS LEFT VENTRICULAR UNLOADING FOR PEDIATRIC MECHANICAL CIRCULATORY SUPPORT

PubMed Central

Bartoli, Carlo R.; Koenig, Steven C.; Ionan, Constantine; Gillars, Kevin J.; Mitchell, Mike E.; Austin, Erle H.; Gray, Laman A.; Pantalos, George M.

2014-01-01

OBJECTIVE Despite progress with adult ventricular assist devices (VADs), limited options exist to support pediatric patients with life-threatening heart disease. Extracorporeal membrane oxygenation (ECMO) remains the clinical standard. To characterize (patho)physiologic responses to different modes of mechanical unloading of the failing pediatric heart, ECMO was compared to either intraaortic balloon pump (IABP), pulsatile-flow (PF)VAD, or continuous-flow (CF)VAD support in a pediatric heart failure model. DESIGN Experimental. SETTING Large animal laboratory operating room. SUBJECTS Yorkshire piglets (n=47, 11.7±2.6 kg). INTERVENTIONS In piglets with coronary ligation-induced cardiac dysfunction, mechanical circulatory support devices were implanted and studied during maximum support. MEASUREMENTS and MAIN RESULTS Left ventricular, right ventricular, coronary, carotid, systemic arterial, and pulmonary arterial hemodynamics were measured with pressure and flow transducers. Myocardial oxygen consumption and total-body oxygen consumption (VO2) were calculated from arterial, venous, and coronary sinus blood sampling. Blood flow was measured in 17 organs with microspheres. Paired student t-tests compared baseline and heart failure conditions. One-way repeated-measures ANOVA compared heart failure, device support mode(s), and ECMO. Statistically significant (p<0.05) findings included: 1) improved left ventricular blood supply/demand ratio during PFVAD, CFVAD, and ECMO but not IABP support, 2) improved global myocardial blood supply/demand ratio during PFVAD, and CFVAD but not IABP or ECMO support, and 3) diminished pulsatility during ECMO and CFVAD but not IABP and PFVAD support. A profile of systems-based responses was established for each type of support. CONCLUSIONS Each type of pediatric VAD provided hemodynamic support by unloading the heart with a different mechanism that created a unique profile of physiological changes. These data contribute novel, clinically relevant insight into pediatric mechanical circulatory support and establish an important resource for pediatric device development and patient selection. PMID:24108116

The accuracy of portable peak flow meters.

PubMed

Miller, M R; Dickinson, S A; Hitchings, D J

1992-11-01

The variability of peak expiratory flow (PEF) is now commonly used in the diagnosis and management of asthma. It is essential for PEF meters to have a linear response in order to obtain an unbiased measurement of PEF variability. As the accuracy and linearity of portable PEF meters have not been rigorously tested in recent years this aspect of their performance has been investigated. The response of several portable PEF meters was tested with absolute standards of flow generated by a computer driven, servo controlled pump and their response was compared with that of a pneumotachograph. For each device tested the readings were highly repeatable to within the limits of accuracy with which the pointer position can be assessed by eye. The between instrument variation in reading for six identical devices expressed as a 95% confidence limit was, on average across the range of flows, +/- 8.5 l/min for the Mini-Wright, +/- 7.9 l/min for the Vitalograph, and +/- 6.4 l/min for the Ferraris. PEF meters based on the Wright meter all had similar error profiles with overreading of up to 80 l/min in the mid flow range from 300 to 500 l/min. This overreading was greatest for the Mini-Wright and Ferraris devices, and less so for the original Wright and Vitalograph meters. A Micro-Medical Turbine meter was accurate up to 400 l/min and then began to underread by up to 60 l/min at 720 l/min. For the low range devices the Vitalograph device was accurate to within 10 l/min up to 200 l/min, with the Mini-Wright overreading by up to 30 l/min above 150 l/min. Although the Mini-Wright, Ferraris, and Vitalograph meters gave remarkably repeatable results their error profiles for the full range meters will lead to important errors in recording PEF variability. This may lead to incorrect diagnosis and bias in implementing strategies of asthma treatment based on PEF measurement.

The accuracy of portable peak flow meters.

PubMed Central

Miller, M R; Dickinson, S A; Hitchings, D J

1992-01-01

BACKGROUND: The variability of peak expiratory flow (PEF) is now commonly used in the diagnosis and management of asthma. It is essential for PEF meters to have a linear response in order to obtain an unbiased measurement of PEF variability. As the accuracy and linearity of portable PEF meters have not been rigorously tested in recent years this aspect of their performance has been investigated. METHODS: The response of several portable PEF meters was tested with absolute standards of flow generated by a computer driven, servo controlled pump and their response was compared with that of a pneumotachograph. RESULTS: For each device tested the readings were highly repeatable to within the limits of accuracy with which the pointer position can be assessed by eye. The between instrument variation in reading for six identical devices expressed as a 95% confidence limit was, on average across the range of flows, +/- 8.5 l/min for the Mini-Wright, +/- 7.9 l/min for the Vitalograph, and +/- 6.4 l/min for the Ferraris. PEF meters based on the Wright meter all had similar error profiles with overreading of up to 80 l/min in the mid flow range from 300 to 500 l/min. This overreading was greatest for the Mini-Wright and Ferraris devices, and less so for the original Wright and Vitalograph meters. A Micro-Medical Turbine meter was accurate up to 400 l/min and then began to underread by up to 60 l/min at 720 l/min. For the low range devices the Vitalograph device was accurate to within 10 l/min up to 200 l/min, with the Mini-Wright overreading by up to 30 l/min above 150 l/min. CONCLUSION: Although the Mini-Wright, Ferraris, and Vitalograph meters gave remarkably repeatable results their error profiles for the full range meters will lead to important errors in recording PEF variability. This may lead to incorrect diagnosis and bias in implementing strategies of asthma treatment based on PEF measurement. PMID:1465746

Interactions Between Channel Topography and Hydrokinetic Turbines: Sediment Transport, Turbine Performance, and Wake Characteristics

NASA Astrophysics Data System (ADS)

Hill, Craig Steven

Accelerating marine hydrokinetic (MHK) renewable energy development towards commercial viability requires investigating interactions between the engineered environment and its surrounding physical and biological environments. Complex and energetic hydrodynamic and morphodynamic environments desired for such energy conversion installations present difficulties for designing efficient yet robust sustainable devices, while permitting agency uncertainties regarding MHK device environmental interactions result in lengthy and costly processes prior to installing and demonstrating emerging technologies. A research program at St. Anthony Falls Laboratory (SAFL), University of Minnesota, utilized multi-scale physical experiments to study the interactions between axial-flow hydrokinetic turbines, turbulent open channel flow, sediment transport, turbulent turbine wakes, and complex hydro-morphodynamic processes in channels. Model axial-flow current-driven three-bladed turbines (rotor diameters, dT = 0.15m and 0.5m) were installed in open channel flumes with both erodible and non-erodible substrates. Device-induced local scour was monitored over several hydraulic conditions and material sizes. Synchronous velocity, bed elevation and turbine performance measurements provide an indication into the effect channel topography has on device performance. Complimentary experiments were performed in a realistic meandering outdoor research channel with active sediment transport to investigate device interactions with bedform migration and secondary turbulent flow patterns in asymmetric channel environments. The suite of experiments undertaken during this research program at SAFL in multiple channels with stationary and mobile substrates under a variety of turbine configurations provides an in-depth investigation into how axial-flow hydrokinetic devices respond to turbulent channel flow and topographic complexity, and how they impact local and far-field sediment transport characteristics. Results provide the foundation for investigating advanced turbine control strategies for optimal power production in non-stationary environments, while also providing a robust data-set for computational model validation for further investigating the interactions between energy conversion devices and the physical environment.

Determination of Heritage SSME Pogo Suppressor Resistance and Inertance from Waterflow Pulse Testing

NASA Technical Reports Server (NTRS)

McDougal, Chris; Eberhart, Chad; Lee, Erik

2016-01-01

Waterflow tests of a heritage Space Shuttle Main Engine pogo suppressor were performed to experimentally quantify the resistance and inertance provided by the suppressor. Measurements of dynamic pressure and flow rate in response to pulsing flow were made throughout the test loop. A unique system identification methodology combined all sensor measurements with a one-dimensional perturbational flow model of the complete water flow loop to spatially translate physical measurements to the device under test. Multiple techniques were then employed to extract the effective resistance and inertance for the pogo suppressor. Parameters such as steady flow rate, perturbational flow rate magnitude, and pulse frequency were investigated to assess their influence on the behavior of the pogo suppressor dynamic response. These results support validation of the RS-25 pogo suppressor performance for use on the Space Launch System Core Stage.

Three-dimensional flow measurements in a tesla turbine rotor

NASA Astrophysics Data System (ADS)

Fuchs, Thomas; Schosser, Constantin; Hain, Rainer; Kaehler, Christian

2015-11-01

Tesla turbines are fluid mechanical devices converting flow energy into rotation energy by two physical effects: friction and adhesion. The advantages of the tesla turbine are its simple and robust design, as well as its scalability, which makes it suitable for custom power supply solutions, and renewable energy applications. To this day, there is a lack of experimental data to validate theoretical studies, and CFD simulations of these turbines. This work presents a comprehensive analysis of the flow through a tesla turbine rotor gap, with a gap height of only 0.5 mm, by means of three-dimensional Particle Tracking Velocimetry (3D-PTV). For laminar flows, the experimental results match the theory very well, since the measured flow profiles show the predicted second order parabolic shape in radial direction and a fourth order behavior in circumferential direction. In addition to these laminar measurements, turbulent flows at higher mass flow rates were investigated.

Increasing Plasma Parameters using Sheared Flow Stabilization of a Z-Pinch

NASA Astrophysics Data System (ADS)

Shumlak, Uri

2016-10-01

Recent experiments on the ZaP Flow Z-Pinch at the University of Washington have been successful in compressing the plasma column to smaller radii, producing the predicted increases in plasma density (1018 cm-3), temperature (200 eV), and magnetic fields (4 T), while maintaining plasma stability for many Alfven times (over 40 μs) using sheared plasma flows. These results indicate the suitability of the device as a discovery science platform for astrophysical and high energy density plasma research, and keeps open a possible path to achieving burning plasma conditions in a compact fusion device. Long-lived Z-pinch plasmas have been produced with dimensions of 1 cm radius and 100 cm long that are stabilized by sheared axial flows for over 1000 Alfven radial transit times. The observed plasma stability is coincident with the presence of a sheared flow as measured by time-resolved multi-chord ion Doppler spectroscopy applied to impurity ion radiation. These measurements yield insights into the evolution of the velocity profile and show that the stabilizing behavior of flow shear agrees with theoretical calculations and 2-D MHD computational simulations. The flow shear value, extent, and duration are shown to be consistent with theoretical models of the plasma viscosity, which places a design constraint on the maximum axial length of a sheared flow stabilized Z-pinch. Measurements of the magnetic field topology indicate simultaneous azimuthal symmetry and axial uniformity along the entire 100 cm length of the Z-pinch plasma. Separate control of plasma acceleration and compression have increased the accessible plasma parameters and have generated stable plasmas with radii below 0.5 cm, as measured with a high resolution digital holographic interferometer. This work was supported by Grants from U.S. DOE, NNSA, and ARPA-E.

Medical-device risk management and public safety: using cost-benefit as a measurement of effectiveness

NASA Astrophysics Data System (ADS)

Hughes, Allen A.

1994-12-01

Public safety can be enhanced through the development of a comprehensive medical device risk management. This can be accomplished through case studies using a framework that incorporates cost-benefit analysis in the evaluation of risk management attributes. This paper presents a framework for evaluating the risk management system for regulatory Class III medical devices. The framework consists of the following sixteen attributes of a comprehensive medical device risk management system: fault/failure analysis, premarket testing/clinical trials, post-approval studies, manufacturer sponsored hospital studies, product labeling, establishment inspections, problem reporting program, mandatory hospital reporting, medical literature surveillance, device/patient registries, device performance monitoring, returned product analysis, autopsy program, emergency treatment funds/interim compensation, product liability, and alternative compensation mechanisms. Review of performance histories for several medical devices can reveal the value of information for many attributes, and also the inter-dependencies of the attributes in generating risk information flow. Such an information flow network is presented as a starting point for enhancing medical device risk management by focusing on attributes with high net benefit values and potential to spur information dissemination.

High pressure stopped-flow apparatus for the rapid mixing and subsequent study of two fluids under high hydrostatic pressures

NASA Astrophysics Data System (ADS)

Karan, Daniel M.; Macey, Robert I.

1980-08-01

A stopped-flow apparatus is described for the rapid mixing and subsequent study of two dissimilar fluids under pressures up to 1200 bar. The device consists of two identical pressure chambers which contain the two fluids, a third pressure chamber which contains gas to maintain the pressure in the system, an optical port for photometric observation, and various connections. The device has been used to measure reaction times on the order of a hundred milliseconds to tens of seconds, using a maximum of 2 ml of each reagent per experimental determination. The dead time is found to be 5-25 ms with minium average flow velocities of 2.0 m/s. The construction and operation of the device are described and examples of water transport data in red blood cells and the bromophenolblue indicated chemical reaction of NaHCO3 and HCl under pressure are presented.

Microfluidics and Coagulation Biology

PubMed Central

Colace, Thomas V.; Tormoen, Garth W.

2014-01-01

The study of blood ex vivo can occur in closed or open systems, with or without flow. Microfluidic devices facilitate measurements of platelet function, coagulation biology, cellular biorheology, adhesion dynamics, pharmacology, and clinical diagnostics. An experimental session can accommodate 100s to 1000s of unique clotting events. Using microfluidics, thrombotic events can be studied on defined surfaces of biopolymers, matrix proteins, and tissue factor under constant flow rate or constant pressure drop conditions. Distinct shear rates can be created on a device with a single perfusion pump. Microfluidic devices facilitated the determination of intraluminal thrombus permeability and the discovery that platelet contractility can be activated by a sudden decrease in flow. Microfluidics are ideal for multicolor imaging of platelets, fibrin, and phosphatidylserine and provide a human blood analog to the mouse injury models. Overall, microfluidic advances offer many opportunities for research, drug testing under relevant hemodynamic conditions, and clinical diagnostics. PMID:23642241

Monitoring of multiphase flows for superconducting accelerators and others applications

NASA Astrophysics Data System (ADS)

Filippov, Yu. P.; Kakorin, I. D.; Kovrizhnykh, A. M.; Miklayev, V. M.

2017-07-01

This paper is a review on implementation of measuring systems for two-phase helium, hydrogen, liquefied natural gas (LNG), and oil-formation/salty water flows. Two types of such systems are presented. The first type is based on two-phase flow-meters combining void fraction radio-frequency (RF) sensors and narrowing devices. They can be applied for superconducting accelerators cooled with two-phase helium, refueling hydrogen system for space ships and some applications in oil production industry. The second one is based on combination of a gamma-densitometer and a narrowing device. These systems can be used to monitor large two-phase LNG and oil-formation water flows. An electronics system based on a modular industrial computer is described as well. The metrological characteristics for different flow-meters are presented and the obtained results are discussed. It is also shown that the experience gained allows separationless flow-meter for three-phase oil-gas-formation water flows to be produced.

Aerosol mobility size spectrometer

DOEpatents

Wang, Jian; Kulkarni, Pramod

2007-11-20

A device for measuring aerosol size distribution within a sample containing aerosol particles. The device generally includes a spectrometer housing defining an interior chamber and a camera for recording aerosol size streams exiting the chamber. The housing includes an inlet for introducing a flow medium into the chamber in a flow direction, an aerosol injection port adjacent the inlet for introducing a charged aerosol sample into the chamber, a separation section for applying an electric field to the aerosol sample across the flow direction and an outlet opposite the inlet. In the separation section, the aerosol sample becomes entrained in the flow medium and the aerosol particles within the aerosol sample are separated by size into a plurality of aerosol flow streams under the influence of the electric field. The camera is disposed adjacent the housing outlet for optically detecting a relative position of at least one aerosol flow stream exiting the outlet and for optically detecting the number of aerosol particles within the at least one aerosol flow stream.

Simultaneous imaging of oxygen tension and blood flow in animals using a digital micromirror device.

PubMed

Ponticorvo, Adrien; Dunn, Andrew K

2010-04-12

In this study we present a novel imaging method that combines high resolution cerebral blood flow imaging with a highly flexible map of absolute pO(2). In vivo measurements of pO(2) in animals using phosphorescence quenching is a well established method, and is preferable over electrical probes which are inherently invasive and are limited to single point measurements. However, spatially resolved pO(2) measurements using phosphorescence lifetime quenching typically require expensive cameras to obtain images of pO(2) and often suffer from poor signal to noise. Our approach enables us to retain the high temporal resolution and sensitivity of single point detection of phosphorescence by using a digital micromirror device (DMD) to selectively illuminate arbitrarily shaped regions of tissue. In addition, by simultaneously using Laser Speckle Contrast Imaging (LSCI) to measure relative blood flow, we can better examine the relationship between blood flow and absolute pO(2). We successfully used this instrument to study changes that occur during ischemic conditions in the brain with enough spatial resolution to clearly distinguish different regions. This novel instrument will provide researchers with an inexpensive and improved technique to examine multiple hemodynamic parameters simultaneously in the brain as well as other tissues.

A feasability study of color flow doppler vectorization for automated blood flow monitoring.

PubMed

Schorer, R; Badoual, A; Bastide, B; Vandebrouck, A; Licker, M; Sage, D

2017-12-01

An ongoing issue in vascular medicine is the measure of the blood flow. Catheterization remains the gold standard measurement method, although non-invasive techniques are an area of intense research. We hereby present a computational method for real-time measurement of the blood flow from color flow Doppler data, with a focus on simplicity and monitoring instead of diagnostics. We then analyze the performance of a proof-of-principle software implementation. We imagined a geometrical model geared towards blood flow computation from a color flow Doppler signal, and we developed a software implementation requiring only a standard diagnostic ultrasound device. Detection performance was evaluated by computing flow and its determinants (flow speed, vessel area, and ultrasound beam angle of incidence) on purposely designed synthetic and phantom-based arterial flow simulations. Flow was appropriately detected in all cases. Errors on synthetic images ranged from nonexistent to substantial depending on experimental conditions. Mean errors on measurements from our phantom flow simulation ranged from 1.2 to 40.2% for angle estimation, and from 3.2 to 25.3% for real-time flow estimation. This study is a proof of concept showing that accurate measurement can be done from automated color flow Doppler signal extraction, providing the industry the opportunity for further optimization using raw ultrasound data.

47 CFR 32.6532 - Network administration expense.

Code of Federal Regulations, 2013 CFR

2013-10-01

... includes such activities as controlling traffic flow, administering traffic measuring and monitoring devices, assigning equipment and load balancing, collecting and summarizing traffic data, administering...

47 CFR 32.6532 - Network administration expense.

Code of Federal Regulations, 2012 CFR

2012-10-01

... includes such activities as controlling traffic flow, administering traffic measuring and monitoring devices, assigning equipment and load balancing, collecting and summarizing traffic data, administering...

47 CFR 32.6532 - Network administration expense.

Code of Federal Regulations, 2014 CFR

2014-10-01

... includes such activities as controlling traffic flow, administering traffic measuring and monitoring devices, assigning equipment and load balancing, collecting and summarizing traffic data, administering...

Pressure balanced drag turbine mass flow meter

DOEpatents

Dacus, M.W.; Cole, J.H.

1980-04-23

The density of the fluid flowing through a tubular member may be measured by a device comprising a rotor assembly suspended within the tubular member, a fluid bearing medium for the rotor assembly shaft, independent fluid flow lines to each bearing chamber, and a scheme for detection of any difference between the upstream and downstream bearing fluid pressures. The rotor assembly reacts to fluid flow both by rotation and axial displacement; therefore concurrent measurements may be made of the velocity of blade rotation and also bearing pressure changes, where the pressure changes may be equated to the fluid momentum flux imparted to the rotor blades. From these parameters the flow velocity and density of the fluid may be deduced.

Pressure balanced drag turbine mass flow meter

DOEpatents

Dacus, Michael W.; Cole, Jack H.

1982-01-01

The density of the fluid flowing through a tubular member may be measured by a device comprising a rotor assembly suspended within the tubular member, a fluid bearing medium for the rotor assembly shaft, independent fluid flow lines to each bearing chamber, and a scheme for detection of any difference between the upstream and downstream bearing fluid pressures. The rotor assembly reacts to fluid flow both by rotation and axial displacement; therefore concurrent measurements may be made of the velocity of blade rotation and also bearing pressure changes, where the pressure changes may be equated to the fluid momentum flux imparted to the rotor blades. From these parameters the flow velocity and density of the fluid may be deduced.

Mechanical phenotyping of tumor cells using a microfluidic cell squeezer device

NASA Astrophysics Data System (ADS)

Khan, Zeina S.; Kamyabi, Nabiollah; Vanapalli, Siva A.

2013-03-01

Studies have indicated that cancer cells have distinct mechanical properties compared to healthy cells. We are investigating the potential of cell mechanics as a biophysical marker for diagnostics and prognosis of cancer. To establish the significance of mechanical properties for cancer diagnostics, a high throughput method is desired. Although techniques such as atomic force microscopy are very precise, they are limited in throughput for cellular mechanical property measurements. To develop a device for high throughput mechanical characterization of tumor cells, we have fabricated a microfludic cell squeezer device that contains narrow micrometer-scale pores. Fluid flow is used to drive cells into these pores mimicking the flow-induced passage of circulating tumor cells through microvasculature. By integrating high speed imaging, the device allows for the simultaneous characterization of five different parameters including the blockage pressure, cell velocity, cell size, elongation and the entry time into squeezer. We have tested a variety of in vitro cell lines, including brain and prostate cancer cell lines, and have found that the entry time is the most sensitive measurement capable of differentiating between cell lines with differing invasiveness.

Assessment of a miniature four-roll mill and a cross-slot microchannel for high-strain-rate stagnation point flows

NASA Astrophysics Data System (ADS)

Akbaridoust, Farzan; Philip, Jimmy; Marusic, Ivan

2018-04-01

Stagnation point flows have been widely used to study the deformation and break-up of objects in two-dimensional pure straining flows. Here, we report a systematic study of the characterisation of stagnation point flows in two devices, a miniature Taylor’s four-roll mill and a cross-slot microchannel. The aim of the study is to find the best platform suitable for investigating the effect of strain rate on the mechanical properties of waterborne microorganisms. Using micro-PIV, the velocity field and the strain rates in both devices were measured at different flow rates and compared with an ideal hyperbolic stagnation point flow. The cross-slot microchannel was found to be a better experimental device than the miniature four-roll mill for the purpose of confining micron-sized objects in a controlled stagnation point flow. This is mainly due to the difficulty of maintaining a fixed location for the stagnation point within one micron in the miniature four-roll mill and achieving high strain rates beyond 10 s-1 . However, with no moving parts, the cross-slot microchannel was found to maintain a steady flow, with the stagnation point varying less than one micron at a cross-junction of 400× 400~μm2 , and was able to reach uniform strain rates up to 140 s-1 .

Define and Quantify the Physics of Air Flow, Pressure Drop and Aerosol Collection in Nuclear Grade HEPA Filters

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moore, Murray E.

Objective: Develop a set of peer-review and verified analytical methods to adjust HEPA filter performance to different flow rates, temperatures and altitudes. Experimental testing will measure HEPA filter flow rate, pressure drop and efficiency to verify the analytical approach. Nuclear facilities utilize HEPA (High Efficiency Particulate Air) filters to purify air flow for workspace ventilation. However, the ASME AG-1 technical standard (Code on Nuclear Air and Gas Treatment) does not adequately describe air flow measurement units for HEPA filter systems. Specifically, the AG-1 standard does not differentiate between volumetric air flow in ACFM (actual cubic feet per minute)compared to massmore » flow measured in SCFM (standard cubic feet per minute). More importantly, the AG-1 standard has an overall deficiency for using HEPA filter devices at different air flow rates, temperatures, and altitudes. Technical Approach: The collection efficiency and pressure drops of 18 different HEPA filters will be measured over a range of flow rates, temperatures and altitudes. The experimental results will be compared to analytical scoping calculations. Three manufacturers have allocated six HEPA filters each for this effort. The 18 filters will be tested at two different flow rates, two different temperatures and two different altitudes. The 36 total tests will be conducted at two different facilities: the ATI Test facilities (Baltimore MD) and the Los Alamos National Laboratory (Los Alamos NM). The Radiation Protection RP-SVS group at Los Alamos has an aerosol wind tunnel that was originally designed to evaluate small air samplers. In 2010, modifications were started to convert the wind tunnel for HEPA filter testing. (Extensive changes were necessary for the required aerosol generators, HEPA test fixtures, temperature control devices and measurement capabilities.) To this date, none of these modification activities have been funded through a specific DOE or NNSA program. This is expected to require six months of time, after receipt of funding. Benefits: US DOE facilities that use HEPA filters will benefit from access to the new operational measurement methods. Uncertainty and guesswork will be removed from HEPA filter operations.« less

AMPS data management requirements study, appendix 1. [user manuals (computer programs)/display devices - computerized simulation/experimentation/ionosphere

NASA Technical Reports Server (NTRS)

1975-01-01

Flow charts and display formats for the simulation of five experiments are given. The experiments are: (1) electromagnetic wave transmission; (2) passive observations of ambient plasma; (3) ionospheric measurements with subsatellite; (4) electron accelerator beam measurements; and (5) measurement of acoustical gravity waves in the sodium layer using lasers. A detailed explanation of the simulation procedure, definition of variables, and an explanation of how the experimenter makes display choices is also presented. A functional description is included on each flow chart and the assumptions and definitions of terms and scope of the flow charts and displays are presented.

A self-loading microfluidic device for determining the minimum inhibitory concentration of antibiotics.

PubMed

Cira, Nate J; Ho, Jack Y; Dueck, Megan E; Weibel, Douglas B

2012-03-21

This article describes a portable microfluidic technology for determining the minimum inhibitory concentration (MIC) of antibiotics against bacteria. The microfluidic platform consists of a set of chambers molded in poly(dimethylsiloxane) (PDMS) that are preloaded with antibiotic, dried, and reversibly sealed to a second layer of PDMS containing channels that connect the chambers. The assembled device is degassed via vacuum prior to its use, and the absorption of gas by PDMS provides the mechanism for actuating and metering the flow of fluid in the microfluidic channels and chambers. During the operation of the device, degas driven flow introduces a suspension of bacterial cells, dissolves the antibiotic, and isolates cells in individual chambers without cross contamination. The growth of bacteria in the chambers in the presence of a pH indicator produces a colorimetric change that can be detected visually using ambient light. Using this device we measured the MIC of vancomycin, tetracycline, and kanamycin against Enterococcus faecalis 1131, Proteus mirabilis HI4320, Klebsiella pneumoniae, and Escherichia coli MG1655 and report values that are comparable to standard liquid broth dilution measurements. The device provides a simple method for MIC determination of individual antibiotics against human pathogens that will have applications for clinical and point-of-care medicine. Importantly, this device is designed around simplicity: it requires a single pipetting step to introduce the sample, no additional components or external equipment for its operation, and provides a straightforward visual measurement of cell growth. As the device introduces a novel approach for filling and isolating dead-end microfluidic chambers that does not require valves and actuators, this technology should find applications in other portable assays and devices.

3D-Printed Fluidic Devices for Nanoparticle Preparation and Flow-Injection Amperometry Using Integrated Prussian Blue Nanoparticle-Modified Electrodes

PubMed Central

Bishop, Gregory W.; Satterwhite, Jennifer E.; Bhakta, Snehasis; Kadimisetty, Karteek; Gillette, Kelsey M.; Chen, Eric; Rusling, James F.

2015-01-01

A consumer-grade fused filament fabrication (FFF) 3D printer was used to construct fluidic devices for nanoparticle preparation and electrochemical sensing. Devices were printed using poly(ethylene terephthalate) and featured threaded ports to connect polyetheretherketone (PEEK) tubing via printed fittings prepared from acrylonitrile butadiene styrene (ABS). These devices included channels designed to have 800 × 800 µm2 square cross sections and were semitransparent to allow visualization of the solution-filled channels. A 3D-printed device with a Y-shaped mixing channel was used to prepare Prussian blue nanoparticles (PBNPs) under flow rates of 100 to 2000 µL min−1. PBNPs were then attached to gold electrodes for hydrogen peroxide sensing. 3D-printed devices used for electrochemical measurements featured threaded access ports into which a fitting equipped with reference, counter, and PBNP-modified working electrodes could be inserted. PBNP-modified electrodes enabled amperometric detection of H2O2 in the 3D-printed channel by flow-injection analysis, exhibiting a detection limit of 100 nM and linear response up to 20 µM. These experiments show that a consumer-grade FFF printer can be used to fabricate low-cost fluidic devices for applications similar to those that have been reported with more expensive 3D-printing methods. PMID:25901660

The flip-flop nozzle extended to supersonic flows

NASA Technical Reports Server (NTRS)

Raman, Ganesh; Hailye, Michael; Rice, Edward J.

1992-01-01

An experiment studying a fluidically oscillated rectangular jet flow was conducted. The Mach number was varied over a range from low subsonic to supersonic. Unsteady velocity and pressure measurements were made using hot wires and piezoresistive pressure transducers. In addition smoke flow visualization using high speed photography was used to document the oscillation of the jet. For the subsonic flip-flop jet it was found that the apparent time-mean widening of the jet was not accompanied by an increase in mass flux. It was found that it is possible to extend the operation of these devices to supersonic flows. Most of the measurements were made for a fixed nozzle geometry for which the oscillations ceased at a fully expanded Mach number of 1.58. By varying the nozzle geometry this limitation was overcome and operation was extended to Mach 1.8. The streamwise velocity perturbation levels produced by this device were much higher than the perturbation levels that could be produced using conventional excitation sources such as acoustic drivers. In view of this ability to produce high amplitudes, the potential for using small scale fluidically oscillated jet as an unsteady excitation source for the control of shear flows in full scale practical applications seems promising.

The flip flop nozzle extended to supersonic flows

NASA Technical Reports Server (NTRS)

Raman, Ganesh; Hailye, Michael; Rice, Edward J.

1992-01-01

An experiment studying a fluidically oscillated rectangular jet flow was conducted. The Mach number was varied over a range from low subsonic to supersonic. Unsteady velocity and pressure measurements were made using hot wires and piezoresistive pressure transducers. In addition smoke flow visualization using high speed photography was used to document the oscillation of the jet. For the subsonic flip-flop jet it was found that the apparent time-mean widening of the jet was not accompanied by an increase in mass flux. It was found that it is possible to extend the operation of these devices to supersonic flows. Most of the measurements were made for a fixed nozzle geometry for which the oscillations ceased at a fully expanded Mach number of 1.58. By varying the nozzle geometry this limitation was overcome and operation was extended to Mach 1.8. The streamwise velocity perturbation levels produced by this device were much higher than the perturbation levels that could be produced using conventional excitation sources such as acoustic drivers. In view of this ability to produce high amplitudes, the potential for using small scale fluidically oscillated jet as an unsteady excitation source for the control of shear flows in full scale practical applications seems promising.

Flow Ambiguity: A Path Towards Classically Driven Blind Quantum Computation

NASA Astrophysics Data System (ADS)

Mantri, Atul; Demarie, Tommaso F.; Menicucci, Nicolas C.; Fitzsimons, Joseph F.

2017-07-01

Blind quantum computation protocols allow a user to delegate a computation to a remote quantum computer in such a way that the privacy of their computation is preserved, even from the device implementing the computation. To date, such protocols are only known for settings involving at least two quantum devices: either a user with some quantum capabilities and a remote quantum server or two or more entangled but noncommunicating servers. In this work, we take the first step towards the construction of a blind quantum computing protocol with a completely classical client and single quantum server. Specifically, we show how a classical client can exploit the ambiguity in the flow of information in measurement-based quantum computing to construct a protocol for hiding critical aspects of a computation delegated to a remote quantum computer. This ambiguity arises due to the fact that, for a fixed graph, there exist multiple choices of the input and output vertex sets that result in deterministic measurement patterns consistent with the same fixed total ordering of vertices. This allows a classical user, computing only measurement angles, to drive a measurement-based computation performed on a remote device while hiding critical aspects of the computation.

Advanced boundary layer transition measurement methods for flight applications

NASA Technical Reports Server (NTRS)

Holmes, B. J.; Croom, C. C.; Gail, P. D.; Manuel, G. S.; Carraway, D. L.

1986-01-01

In modern laminar flow flight research, it is important to understand the specific cause(s) of laminar to turbulent boundary-layer transition. Such information is crucial to the exploration of the limits of practical application of laminar flow for drag reduction on aircraft. The transition modes of interest in current flight investigations include the viscous Tollmien-Schlichting instability, the inflectional instability at laminar separation, and the crossflow inflectional instability, as well as others. This paper presents the results to date of research on advanced devices and methods used for the study of laminar boundary-layer transition phenomena in the flight environment. Recent advancements in the development of arrayed hot-film devices and of a new flow visualization method are discussed. Arrayed hot-film devices have been designed to detect the presence of laminar separation, and of crossflow vorticity. The advanced flow visualization method utilizes color changes in liquid-crystal coatings to detect boundary-layer transition at high altitude flight conditions. Flight and wind tunnel data are presented to illustrate the design and operation of these advanced methods. These new research tools provide information on disturbance growth and transition mode which is essential to furthering our understanding of practical design limits for applications of laminar flow technology.

Optimized Lateral Flow Immunoassay Reader for the Detection of Infectious Diseases in Developing Countries.

PubMed

Pilavaki, Evdokia; Demosthenous, Andreas

2017-11-20

Detection and control of infectious diseases is a major problem, especially in developing countries. Lateral flow immunoassays can be used with great success for the detection of infectious diseases. However, for the quantification of their results an electronic reader is required. This paper presents an optimized handheld electronic reader for developing countries. It features a potentially low-cost, low-power, battery-operated device with no added optical accessories. The operation of this proof of concept device is based on measuring the reflected light from the lateral flow immunoassay and translating it into the concentration of the specific analyte of interest. Characterization of the surface of the lateral flow immunoassay has been performed in order to accurately model its response to the incident light. Ray trace simulations have been performed to optimize the system and achieve maximum sensitivity by placing all the components in optimum positions. A microcontroller enables all the signal processing to be performed on the device and a Bluetooth module allows transmission of the results wirelessly to a mobile phone app. Its performance has been validated using lateral flow immunoassays with influenza A nucleoprotein in the concentration range of 0.5 ng/mL to 200 ng/mL.

High-temperature zirconia microthruster with an integrated flow sensor

NASA Astrophysics Data System (ADS)

Lekholm, Ville; Persson, Anders; Palmer, Kristoffer; Ericson, Fredric; Thornell, Greger

2013-05-01

This paper describes the design, fabrication and characterization of a ceramic, heated cold-gas microthruster device made with silicon tools and high temperature co-fired ceramic processing. The device contains two opposing thrusters, each with an integrated calorimetric propellant flow sensor and a heater in the stagnation chamber of the nozzle. The exhaust from a thruster was photographed using schlieren imaging to study its behavior and search for leaks. The heater elements were tested under a cyclic thermal load and to the maximum power before failure. The nozzle heater was shown to improve the efficiency of the thruster by 6.9%, from a specific impulse of 66 to 71 s, as calculated from a decrease of the flow rate through the nozzle of 13%, from 44.9 to 39.2 sccm. The sensitivity of the integrated flow sensor was measured to 0.15 mΩ sccm-1 in the region of 0-15 sccm and to 0.04 mΩ sccm-1 above 20 sccm, with a zero-flow sensitivity of 0.27 mΩ sccm-1. The choice of yttria-stabilized zirconia as a material for the devices makes them robust and capable of surviving temperatures locally exceeding 1000 °C.

40 CFR 65.160 - Performance test and TRE index value determination records.

Code of Federal Regulations, 2013 CFR

2013-07-01

... the control device, the total regeneration stream mass flow during each carbon-bed regeneration cycle... each regeneration during the period of the performance test (and within 15 minutes of completion of any... the recovery system, the total regeneration stream mass flow measured at least every 15 minutes and...

40 CFR 65.160 - Performance test and TRE index value determination records.

Code of Federal Regulations, 2012 CFR

2012-07-01

... the control device, the total regeneration stream mass flow during each carbon-bed regeneration cycle... each regeneration during the period of the performance test (and within 15 minutes of completion of any... the recovery system, the total regeneration stream mass flow measured at least every 15 minutes and...

40 CFR 65.160 - Performance test and TRE index value determination records.

Code of Federal Regulations, 2011 CFR

2011-07-01

... the control device, the total regeneration stream mass flow during each carbon-bed regeneration cycle... each regeneration during the period of the performance test (and within 15 minutes of completion of any... the recovery system, the total regeneration stream mass flow measured at least every 15 minutes and...

40 CFR 65.160 - Performance test and TRE index value determination records.

Code of Federal Regulations, 2014 CFR

2014-07-01

... the control device, the total regeneration stream mass flow during each carbon-bed regeneration cycle... each regeneration during the period of the performance test (and within 15 minutes of completion of any... the recovery system, the total regeneration stream mass flow measured at least every 15 minutes and...

Design and Characterization of a Microfabricated Hydrogen Clearance Blood Flow Sensor

PubMed Central

Walton, Lindsay R.; Edwards, Martin A.; McCarty, Gregory S.; Wightman, R. Mark

2016-01-01

Background Modern cerebral blood flow (CBF) detection favors the use of either optical technologies that are limited to cortical brain regions, or expensive magnetic resonance. Decades ago, inhalation gas clearance was the choice method of quantifying CBF, but this suffered from poor temporal resolution. Electrolytic H2 clearance (EHC) generates and collects gas in situ at an electrode pair, which improves temporal resolution, but the probe size has prohibited meaningful subcortical use. New Method We microfabricated EHC electrodes to an order of magnitude smaller than those existing, on the scale of 100 µm, to permit use deep within the brain. Results Novel EHC probes were fabricated. The devices offered exceptional signal-to-noise, achieved high collection efficiencies (40 – 50%) in vitro, and agreed with theoretical modeling. An in vitro chemical reaction model was used to confirm that our devices detected flow rates higher than those expected physiologically. Computational modeling that incorporated realistic noise levels demonstrated devices would be sensitive to physiological CBF rates. Comparison with Existing Method The reduced size of our arrays makes them suitable for subcortical EHC measurements, as opposed to the larger, existing EHC electrodes that would cause substantial tissue damage. Our array can collect multiple CBF measurements per minute, and can thus resolve physiological changes occurring on a shorter timescale than existing gas clearance measurements. Conclusion We present and characterize microfabricated EHC electrodes and an accompanying theoretical model to interpret acquired data. Microfabrication allows for the high-throughput production of reproducible devices that are capable of monitoring deep brain CBF with sub-minute resolution. PMID:27102042

Methods of measurement signal acquisition from the rotational flow meter for frequency analysis

NASA Astrophysics Data System (ADS)

Świsulski, Dariusz; Hanus, Robert; Zych, Marcin; Petryka, Leszek

One of the simplest and commonly used instruments for measuring the flow of homogeneous substances is the rotational flow meter. The main part of such a device is a rotor (vane or screw) rotating at a speed which is the function of the fluid or gas flow rate. A pulse signal with a frequency proportional to the speed of the rotor is obtained at the sensor output. For measurements in dynamic conditions, a variable interval between pulses prohibits the analysis of the measuring signal. Therefore, the authors of the article developed a method involving the determination of measured values on the basis of the last inter-pulse interval preceding the moment designated by the timing generator. For larger changes of the measured value at a predetermined time, the value can be determined by means of extrapolation of the two adjacent interpulse ranges, assuming a linear change in the flow. The proposed methods allow analysis which requires constant spacing between measurements, allowing for an analysis of the dynamics of changes in the test flow, eg. using a Fourier transform. To present the advantages of these methods simulations of flow measurement were carried out with a DRH-1140 rotor flow meter from the company Kobold.

On-site flow calibration of turbine meters for natural gas custody transfer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ting, V.C.; Schexnayder, L.L.; Conkling, D.B.

1991-05-01

This paper presents the design criteria, performance characteristics, and calibration procedures relating to a turbine-meter flow-calibration facility used in the high-volume custody transfer of natural gas. The facility, located in Venice, LA, is owned and operated by Chevron U.S.A. Inc. and is used to meter sales volumes of up to 500 MMscf/D (14.16 {times} 10 std m{sup 3}/d) at a nominal operating pressure of 1,000 psig (6.9 MPa). The system includes three 12-in. (30.48 cm) turbine meters used for sales-volume measurement, a bank of sonic nozzles, and a master turbine meter connected in series with the sales meters. The sonicmore » nozzles and master meter serve as flow-proving and -calibration devices. sonic nozzles are recommended by the turbine-meter standard for meter calibration. This paper examines the performance of on-site calibration of gas turbine meters. The Venice facility successfully demonstrated that on-site calibration of gas-metering devices can ensure accurate gas-flow measurement under field conditions.« less

PLATELET ADHESION TO POLYURETHANE UREA UNDER PULSATILE FLOW CONDITIONS

PubMed Central

Navitsky, Michael A.; Taylor, Joshua O.; Smith, Alexander B.; Slattery, Margaret J.; Deutsch, Steven; Siedlecki, Christopher A.; Manning, Keefe B.

2014-01-01

Platelet adhesion to a polyurethane urea surface is a precursor to thrombus formation within blood-contacting cardiovascular devices, and platelets have been found to adhere strongly to polyurethane surfaces below a shear rate of approximately 500 s−1. The aim of the current work is to determine platelet adhesion properties to the polyurethane urea surface as a function of time varying shear exposure. A rotating disk system is used to study the influence of steady and pulsatile flow conditions (e.g. cardiac inflow and sawtooth waveforms) for platelet adhesion to the biomaterial surface. All experiments retain the same root mean square angular rotation velocity (29.63 rad/s) and waveform period. The disk is rotated in platelet rich bovine plasma for two hours with adhesion quantified by confocal microscopy measurements of immunofluorescently labeled bovine platelets. Platelet adhesion under pulsating flow is found to exponentially decay with increasing shear rate. Adhesion levels are found to depend upon peak platelet flux and shear rate regardless of rotational waveform. In combination with flow measurements, these results may be useful for predicting regions susceptible to thrombus formation within ventricular assist devices. PMID:24721222

Development and validation of an improved mechanical thorax for simulating cardiopulmonary resuscitation with adjustable chest stiffness and simulated blood flow.

PubMed

Eichhorn, Stefan; Spindler, Johannes; Polski, Marcin; Mendoza, Alejandro; Schreiber, Ulrich; Heller, Michael; Deutsch, Marcus Andre; Braun, Christian; Lange, Rüdiger; Krane, Markus

2017-05-01

Investigations of compressive frequency, duty cycle, or waveform during CPR are typically rooted in animal research or computer simulations. Our goal was to generate a mechanical model incorporating alternate stiffness settings and an integrated blood flow system, enabling defined, reproducible comparisons of CPR efficacy. Based on thoracic stiffness data measured in human cadavers, such a model was constructed using valve-controlled pneumatic pistons and an artificial heart. This model offers two realistic levels of chest elasticity, with a blood flow apparatus that reflects compressive depth and waveform changes. We conducted CPR at opposing levels of physiologic stiffness, using a LUCAS device, a motor-driven plunger, and a group of volunteers. In high-stiffness mode, blood flow generated by volunteers was significantly less after just 2min of CPR, whereas flow generated by LUCAS device was superior by comparison. Optimal blood flow was obtained via motor-driven plunger, with trapezoidal waveform. Copyright © 2017 IPEM. Published by Elsevier Ltd. All rights reserved.

Methodological assessment of skin and limb blood flows in the human forearm during thermal and baroreceptor provocations

PubMed Central

Brothers, R. Matthew; Wingo, Jonathan E.; Hubing, Kimberly A.

2010-01-01

Skin blood flow responses in the human forearm, assessed by three commonly used technologies—single-point laser-Doppler flowmetry, integrated laser-Doppler flowmetry, and laser-Doppler imaging—were compared in eight subjects during normothermic baseline, acute skin-surface cooling, and whole body heat stress (Δ internal temperature = 1.0 ± 0.2°C; P < 0.001). In addition, while normothermic and heat stressed, subjects were exposed to 30-mmHg lower-body negative pressure (LBNP). Skin blood flow was normalized to the maximum value obtained at each site during local heating to 42°C for at least 30 min. Furthermore, comparisons of forearm blood flow (FBF) measures obtained using venous occlusion plethysmography and Doppler ultrasound were made during the aforementioned perturbations. Relative to normothermic baseline, skin blood flow decreased during normothermia + LBNP (P < 0.05) and skin-surface cooling (P < 0.01) and increased during whole body heating (P < 0.001). Subsequent LBNP during whole body heating significantly decreased skin blood flow relative to control heat stress (P < 0.05). Importantly, for each of the aforementioned conditions, skin blood flow was similar between the three measurement devices (main effect of device: P > 0.05 for all conditions). Similarly, no differences were identified across all perturbations between FBF measures using plethysmography and Doppler ultrasound (P > 0.05 for all perturbations). These data indicate that when normalized to maximum, assessment of skin blood flow in response to vasoconstrictor and dilator perturbations are similar regardless of methodology. Likewise, FBF responses to these perturbations are similar between two commonly used methodologies of limb blood flow assessment. PMID:20634360

Methodological assessment of skin and limb blood flows in the human forearm during thermal and baroreceptor provocations.

PubMed

Brothers, R Matthew; Wingo, Jonathan E; Hubing, Kimberly A; Crandall, Craig G

2010-09-01

Skin blood flow responses in the human forearm, assessed by three commonly used technologies-single-point laser-Doppler flowmetry, integrated laser-Doppler flowmetry, and laser-Doppler imaging-were compared in eight subjects during normothermic baseline, acute skin-surface cooling, and whole body heat stress (Δ internal temperature=1.0±0.2 degrees C; P<0.001). In addition, while normothermic and heat stressed, subjects were exposed to 30-mmHg lower-body negative pressure (LBNP). Skin blood flow was normalized to the maximum value obtained at each site during local heating to 42 degrees C for at least 30 min. Furthermore, comparisons of forearm blood flow (FBF) measures obtained using venous occlusion plethysmography and Doppler ultrasound were made during the aforementioned perturbations. Relative to normothermic baseline, skin blood flow decreased during normothermia+LBNP (P<0.05) and skin-surface cooling (P<0.01) and increased during whole body heating (P<0.001). Subsequent LBNP during whole body heating significantly decreased skin blood flow relative to control heat stress (P<0.05). Importantly, for each of the aforementioned conditions, skin blood flow was similar between the three measurement devices (main effect of device: P>0.05 for all conditions). Similarly, no differences were identified across all perturbations between FBF measures using plethysmography and Doppler ultrasound (P>0.05 for all perturbations). These data indicate that when normalized to maximum, assessment of skin blood flow in response to vasoconstrictor and dilator perturbations are similar regardless of methodology. Likewise, FBF responses to these perturbations are similar between two commonly used methodologies of limb blood flow assessment.

Thermal Remote Anemometer Device

NASA Technical Reports Server (NTRS)

Heyman, Joseph S.; Heath, D. Michele; Winfree, William P.; Miller, William E.; Welch, Christopher S.

1988-01-01

Thermal Remote Anemometer Device developed for remote, noncontacting, passive measurement of thermal properties of sample. Model heated locally by scanning laser beam and cooled by wind in tunnel. Thermal image of model analyzed to deduce pattern of airflow around model. For materials applications, system used for evaluation of thin films and determination of thermal diffusivity and adhesive-layer contact. For medical applications, measures perfusion through skin to characterize blood flow and used to determine viabilities of grafts and to characterize tissues.

Pulse Oximeter Derived Blood Pressure Measurement in Patients With a Continuous Flow Left Ventricular Assist Device.

PubMed

Hellman, Yaron; Malik, Adnan S; Lane, Kathleen A; Shen, Changyu; Wang, I-Wen; Wozniak, Thomas C; Hashmi, Zubair A; Munson, Sarah D; Pickrell, Jeanette; Caccamo, Marco A; Gradus-Pizlo, Irmina; Hadi, Azam

2017-05-01

Currently, blood pressure (BP) measurement is obtained noninvasively in patients with continuous flow left ventricular assist device (LVAD) by placing a Doppler probe over the brachial or radial artery with inflation and deflation of a manual BP cuff. We hypothesized that replacing the Doppler probe with a finger-based pulse oximeter can yield BP measurements similar to the Doppler derived mean arterial pressure (MAP). We conducted a prospective study consisting of patients with contemporary continuous flow LVADs. In a small pilot phase I inpatient study, we compared direct arterial line measurements with an automated blood pressure (ABP) cuff, Doppler and pulse oximeter derived MAP. Our main phase II study included LVAD outpatients with a comparison between Doppler, ABP, and pulse oximeter derived MAP. A total of five phase I and 36 phase II patients were recruited during February-June 2014. In phase I, the average MAP measured by pulse oximeter was closer to arterial line MAP rather than Doppler (P = 0.06) or ABP (P < 0.01). In phase II, pulse oximeter MAP (96.6 mm Hg) was significantly closer to Doppler MAP (96.5 mm Hg) when compared to ABP (82.1 mm Hg) (P = 0.0001). Pulse oximeter derived blood pressure measurement may be as reliable as Doppler in patients with continuous flow LVADs. © 2016 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.

Thermocouple Rakes for Measuring Boundary Layer Flows Extremely Close to Surface

NASA Technical Reports Server (NTRS)

Hwang, Danny P.; Fralick, Gustave C.; Martin, Lisa C.; Blaha, Charles A.

2001-01-01

Of vital interest to aerodynamic researchers is precise knowledge of the flow velocity profile next to the surface. This information is needed for turbulence model development and the calculation of viscous shear force. Though many instruments can determine the flow velocity profile near the surface, none of them can make measurements closer than approximately 0.01 in. from the surface. The thermocouple boundary-layer rake can measure much closer to the surface than conventional instruments can, such as a total pressure boundary layer rake, hot wire, or hot film. By embedding the sensors (thermocouples) in the region where the velocity is equivalent to the velocity ahead of a constant thickness strut, the boundary-layer flow profile can be obtained. The present device fabricated at the NASA Glenn Research Center microsystem clean room has a heater made of platinum and thermocouples made of platinum and gold. Equal numbers of thermocouples are placed both upstream and downstream of the heater, so that the voltage generated by each pair at the same distance from the surface is indicative of the difference in temperature between the upstream and downstream thermocouple locations. This voltage differential is a function of the flow velocity, and like the conventional total pressure rake, it can provide the velocity profile. In order to measure flow extremely close to the surface, the strut is made of fused quartz with extremely low heat conductivity. A large size thermocouple boundary layer rake is shown in the following photo. The latest medium size sensors already provide smooth velocity profiles well into the boundary layer, as close as 0.0025 in. from the surface. This is about 4 times closer to the surface than the previously used total pressure rakes. This device also has the advantage of providing the flow profile of separated flow and also it is possible to measure simultaneous turbulence levels within the boundary layer.

Research trend in thermally stimulated current method for development of materials and devices in Japan

NASA Astrophysics Data System (ADS)

Iwamoto, Mitsumasa; Taguchi, Dai

2018-03-01

Thermally stimulated current (TSC) measurement is widely used in a variety of research fields, i.e., physics, electronics, electrical engineering, chemistry, ceramics, and biology. TSC is short-circuit current that flows owing to the displacement of charges in samples during heating. TSC measurement is very simple, but TSC curves give very important information on charge behaviors. In the 1970s, TSC measurement contributed greatly to the development of electrical insulation engineering, semiconductor device technology, and so forth. Accordingly, the TSC experimental technique and its analytical method advanced. Over the past decades, many new molecules and advanced functional materials have been discovered and developed. Along with this, TSC measurement has attracted much attention in industries and academic laboratories as a way of characterizing newly discovered materials and devices. In this review, we report the latest research trend in the TSC method for the development of materials and devices in Japan.

Combined surface-enhanced Raman spectroscopy biotags and microfluidic platform for quantitative ratiometric discrimination between noncancerous and cancerous cells in flow

NASA Astrophysics Data System (ADS)

Pallaoro, Alessia; Hoonejani, Mehran R.; Braun, Gary B.; Meinhart, Carl; Moskovits, Martin

2013-01-01

Surface-enhanced Raman spectroscopy (SERS) biotags (SBTs) that carry peptides as cell recognition moieties were made from polymer-encapsulated silver nanoparticle dimers, infused with unique Raman reporter molecules. We previously demonstrated their potential use for identification of malignant cells, a central goal in cancer research, through a multiplexed, ratiometric method that can confidently distinguish between cancerous and noncancerous epithelial prostate cells in vitro based on receptor overexpression. Progress has been made toward the application of this quantitative methodology for the identification of cancer cells in a microfluidic flow-focusing device. Beads are used as cell mimics to evaluate the devices. Cells (and beads) are simultaneously incubated with two sets of SBTs while in suspension, then injected into the device for laser interrogation under flow. Each cell event is characterized by a composite Raman spectrum, deconvoluted into its single components to ultimately determine their relative contribution. We have found that using SBTs ratiometrically can provide cell identification in flow, insensitive to normal causes of uncertainty in optical measurements such as variations in focal plane, cell concentration, autofluorescence, and turbidity.

Apparatus for monitoring two-phase flow

DOEpatents

Sheppard, John D.; Tong, Long S.

1977-03-01

A method and apparatus for monitoring two-phase flow is provided that is particularly related to the monitoring of transient two-phase (liquid-vapor) flow rates such as may occur during a pressurized water reactor core blow-down. The present invention essentially comprises the use of flanged wire screens or similar devices, such as perforated plates, to produce certain desirable effects in the flow regime for monitoring purposes. One desirable effect is a measurable and reproducible pressure drop across the screen. The pressure drop can be characterized for various known flow rates and then used to monitor nonhomogeneous flow regimes. Another useful effect of the use of screens or plates in nonhomogeneous flow is that such apparatus tends to create a uniformly dispersed flow regime in the immediate downstream vicinity. This is a desirable effect because it usually increases the accuracy of flow rate measurements determined by conventional methods.

Method and apparatus for monitoring two-phase flow. [PWR

DOEpatents

Sheppard, J.D.; Tong, L.S.

1975-12-19

A method and apparatus for monitoring two-phase flow is provided that is particularly related to the monitoring of transient two-phase (liquid-vapor) flow rates such as may occur during a pressurized water reactor core blow-down. The present invention essentially comprises the use of flanged wire screens or similar devices, such as perforated plates, to produce certain desirable effects in the flow regime for monitoring purposes. One desirable effect is a measurable and reproducible pressure drop across the screen. The pressure drop can be characterized for various known flow rates and then used to monitor nonhomogeneous flow regimes. Another useful effect of the use of screens or plates in nonhomogeneous flow is that such apparatus tends to create a uniformly dispersed flow regime in the immediate downstream vicinity. This is a desirable effect because it usually increases the accuracy of flow rate measurements determined by conventional methods.

Device Management and Flow Optimization on Left Ventricular Assist Device Support.

PubMed

Tchoukina, Inna; Smallfield, Melissa C; Shah, Keyur B

2018-07-01

The authors discuss principles of continuous flow left ventricular assist device (LVAD) operation, basic differences between the axial and centrifugal flow designs and hemodynamic performance, normal LVAD physiology, and device interaction with the heart. Systematic interpretation of LVAD parameters and recognition of abnormal patterns of flow and pulsatility on the device interrogation are necessary for clinical assessment of the patient. Optimization of pump flow using LVAD parameters and echocardiographic and hemodynamics guidance are reviewed. Copyright © 2018 Elsevier Inc. All rights reserved.

FISH-Flow, a protocol for the concurrent detection of mRNA and protein in single cells using fluorescence in situ hybridization and flow cytometry

PubMed Central

Arrigucci, Riccardo; Bushkin, Yuri; Radford, Felix; Lakehal, Karim; Vir, Pooja; Pine, Richard; Martin, December; Sugarman, Jeffrey; Zhao, Yanlin; Yap, George S; Lardizabal, Alfred A; Tyagi, Sanjay; Gennaro, Maria Laura

2017-01-01

We describe a flow-cytometry-based protocol for intracellular mRNA measurements in nonadherent mammalian cells using fluorescence in situ hybridization (FISH) probes. The method, which we call FISH-Flow, allows for high-throughput multiparametric measurements of gene expression, a task that was not feasible with earlier, microscopy-based approaches. The FISH-Flow protocol involves cell fixation, permeabilization and hybridization with a set of fluorescently labeled oligonucleotide probes. In this protocol, surface and intracellular protein markers can also be stained with fluorescently labeled antibodies for simultaneous protein and mRNA measurement. Moreover, a semiautomated, single-tube version of the protocol can be performed with a commercially available cell-wash device that reduces cell loss, operator time and interoperator variability. It takes ~30 h to perform this protocol. An example of FISH-Flow measurements of cytokine mRNA induction by ex vivo stimulation of primed T cells with specific antigens is described. PMID:28518171

Fast blood flow monitoring in deep tissues with real-time software correlators

PubMed Central

Wang, Detian; Parthasarathy, Ashwin B.; Baker, Wesley B.; Gannon, Kimberly; Kavuri, Venki; Ko, Tiffany; Schenkel, Steven; Li, Zhe; Li, Zeren; Mullen, Michael T.; Detre, John A.; Yodh, Arjun G.

2016-01-01

We introduce, validate and demonstrate a new software correlator for high-speed measurement of blood flow in deep tissues based on diffuse correlation spectroscopy (DCS). The software correlator scheme employs standard PC-based data acquisition boards to measure temporal intensity autocorrelation functions continuously at 50 – 100 Hz, the fastest blood flow measurements reported with DCS to date. The data streams, obtained in vivo for typical source-detector separations of 2.5 cm, easily resolve pulsatile heart-beat fluctuations in blood flow which were previously considered to be noise. We employ the device to separate tissue blood flow from tissue absorption/scattering dynamics and thereby show that the origin of the pulsatile DCS signal is primarily flow, and we monitor cerebral autoregulation dynamics in healthy volunteers more accurately than with traditional instrumentation as a result of increased data acquisition rates. Finally, we characterize measurement signal-to-noise ratio and identify count rate and averaging parameters needed for optimal performance. PMID:27231588

In vitro characterization of a magnetically suspended continuous flow ventricular assist device.

PubMed

Kim, H C; Bearnson, G B; Khanwilkar, P S; Olsen, D B; Maslen, E H; Allaire, P E

1995-01-01

A magnetically suspended continuous flow ventricular assist device using magnetic bearings was developed aiming at an implantable ventricular assist device. The main advantage of this device includes no mechanical wear and minimal chance of blood trauma such, as thrombosis and hemolysis, because there is no mechanical contact between the stationary and rotating parts. The total system consists of two subsystems: the centrifugal pump and the magnetic bearing. The centrifugal pump is comprised of a 4 vane logarithmic spiral radial flow impeller and a brushless DC motor with slotless stator, driven by the back emf commutation scheme. Two radial and one thrust magnetic bearing that dynamically controls the position of the rotor in a radial and axial direction, respectively, contains magnetic coils, the rotor's position sensors, and feedback electronic control system. The magnetic bearing system was able to successfully suspend a 365.5g rotating part in space and sustain it for up to 5000 rpm of rotation. Average force-current square factor of the magnetic bearing was measured as 0.48 and 0.44 (kg-f/Amp2) for radial and thrust bearing, respectively. The integrated system demonstrated adequate performance in mock circulation tests by providing a 6 L/min flow rate against 100 mmHg differential pressure at 2300 rpm. Based on these in vitro performance test results, long-term clinical application of the magnetically suspended continuous flow ventricular assist device is very promising after system optimization with a hybrid system using both active (electromagnet) and passive (permanent magnets) magnet bearings.

Method of processing a substrate

DOEpatents

Babayan, Steven E [Huntington Beach, CA; Hicks, Robert F [Los Angeles, CA

2008-02-12

The invention is embodied in a plasma flow device or reactor having a housing that contains conductive electrodes with openings to allow gas to flow through or around them, where one or more of the electrodes are powered by an RF source and one or more are grounded, and a substrate or work piece is placed in the gas flow downstream of the electrodes, such that said substrate or work piece is substantially uniformly contacted across a large surface area with the reactive gases emanating therefrom. The invention is also embodied in a plasma flow device or reactor having a housing that contains conductive electrodes with openings to allow gas to flow through or around them, where one or more of the electrodes are powered by an RF source and one or more are grounded, and one of the grounded electrodes contains a means of mixing in other chemical precursors to combine with the plasma stream, and a substrate or work piece placed in the gas flow downstream of the electrodes, such that said substrate or work piece is contacted by the reactive gases emanating therefrom. In one embodiment, the plasma flow device removes organic materials from a substrate or work piece, and is a stripping or cleaning device. In another embodiment, the plasma flow device kills biological microorganisms on a substrate or work piece, and is a sterilization device. In another embodiment, the plasma flow device activates the surface of a substrate or work piece, and is a surface activation device. In another embodiment, the plasma flow device etches materials from a substrate or work piece, and is a plasma etcher. In another embodiment, the plasma flow device deposits thin films onto a substrate or work piece, and is a plasma-enhanced chemical vapor deposition device or reactor.

Experimental observations of granular debris flows

NASA Astrophysics Data System (ADS)

Ghilardi, P.

2003-04-01

Various tests are run using two different laboratory flumes with rectangular cross section and transparent walls. The grains used in a single experiment have an almost constant grain sizes; mean diameter ranges from 5 mm to 20 mm. In each test various measurements are taken: hydrograms, velocity distribution near the transparent walls and on the free surface, average flow concentration. Concentration values are measured taking samples. Velocity distributions are obtained from movies recorded by high speed video cameras capable of 350 frames per second; flow rates and depth hydrograms are computed from the same velocity distributions. A gate is installed at the beginning of one of the flumes; this gate slides normally to the bed and opens very quickly, reproducing a dam-break. Several tests are run using this device, varying channel slope, sediment concentration, initial mixture thickness before the gate. Velocity distribution in the flume is almost constant from left to right, except for the flow sections near the front. The observed discharges and velocities are less than those given by a classic dam break formula, and depend on sediment concentration. The other flume is fed by a mixture with constant discharge and concentration, and is mainly used for measuring velocity distributions when the flow is uniform, with both rigid and granular bed, and to study erosion/deposition processes near debris flow dams or other mitigation devices. The equilibrium slope of the granular bed is very close to that given by the classical equilibrium formulas for debris flow. Different deposition processes are observed depending on mixture concentration and channel geometry.

The Study on Flow Velocity Measurement of Antarctic Krill Trawl Model Experiment in North Bay of South China Sea

NASA Astrophysics Data System (ADS)

Chen, Shuai; Wang, Lumin; Huang, Hongliang; Zhang, Xun

2017-10-01

From August 25 to 29, 2014, the project team carried out the experiment of Antarctic krill trawl in the Beihai Bay of the South China Sea. In order to understand the flow field of the network model in the course of the experiment, it is necessary to record the speed of the ship and to grasp the flow field of the ocean. Therefore, the ocean velocity is measured during the experiment. The flow rate in this experiment was measured using an acoustic Doppler flow meter (Vectoring Plus, Nortek, Norway). In order to compensate for the flow rate error caused by ship drift, the drift condition of the ship was also measured by the positioning device (Snapdragon MSM8274AB, Qualcomm, USA) used in the flow rate measurement. The results show that the actual velocity of the target sea area is in the range of 0.06-0.49 m / s and the direction is 216.17-351.70. And compared with the previous research, the influencing factors were analysed. This study proves that it is feasible to use point Doppler flow meter for velocity study in trawl model experiment.

Computer-aided design and experimental investigation of a hydrodynamic device: the microwire electrode

PubMed

Fulian; Gooch; Fisher; Stevens; Compton

2000-08-01

The development and application of a new electrochemical device using a computer-aided design strategy is reported. This novel design is based on the flow of electrolyte solution past a microwire electrode situated centrally within a large duct. In the design stage, finite element simulations were employed to evaluate feasible working geometries and mass transport rates. The computer-optimized designs were then exploited to construct experimental devices. Steady-state voltammetric measurements were performed for a reversible one-electron-transfer reaction to establish the experimental relationship between electrolysis current and solution velocity. The experimental results are compared to those predicted numerically, and good agreement is found. The numerical studies are also used to establish an empirical relationship between the mass transport limited current and the volume flow rate, providing a simple and quantitative alternative for workers who would prefer to exploit this device without the need to develop the numerical aspects.

Totally Implantable Wireless Ultrasonic Doppler Blood Flowmeters: Toward Accurate Miniaturized Chronic Monitors.

PubMed

Rothfuss, Michael A; Unadkat, Jignesh V; Gimbel, Michael L; Mickle, Marlin H; Sejdić, Ervin

2017-03-01

Totally implantable wireless ultrasonic blood flowmeters provide direct-access chronic vessel monitoring in hard-to-reach places without using wired bedside monitors or imaging equipment. Although wireless implantable Doppler devices are accurate for most applications, device size and implant lifetime remain vastly underdeveloped. We review past and current approaches to miniaturization and implant lifetime extension for wireless implantable Doppler devices and propose approaches to reduce device size and maximize implant lifetime for the next generation of devices. Additionally, we review current and past approaches to accurate blood flow measurements. This review points toward relying on increased levels of monolithic customization and integration to reduce size. Meanwhile, recommendations to maximize implant lifetime should include alternative sources of power, such as transcutaneous wireless power, that stand to extend lifetime indefinitely. Coupling together the results will pave the way for ultra-miniaturized totally implantable wireless blood flow monitors for truly chronic implantation. Copyright © 2016 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.

Ion flow measurements during the rotating kink behavior of the central column in the HIST device

NASA Astrophysics Data System (ADS)

Yamada, S.; Yoshikawa, T.; Hashimoto, S.; Nishioka, T.; Kikuchi, Y.; Fukumoto, N.; Nagata, M.

2007-11-01

Plasma flow is essentially driven in self-organization and magnetic reconnection process of compact spherical torus (ST) and spheromak in the helicity-driven systems. For example, when reversing the external toroidal field of ST, the direction not only of the plasma current but also of the toroidal ion flow is self-reversed during the formation of the flipped ST relaxed states. Mach probe measurement shows that the velocity of the ion flow reversed after the flip increases to about 20 km/s. We have been newly developing an ion Doppler spectrometer (IDS) system using a compact 16 or 64 channel photomultiplier tube (PMT) in order to measure the spatial profile of ion temperature and rotation velocity in the HIST device. The IDS system consists of a light collection system including optical fibers, 1 m-spectrometer and the PMT detector. The optical fibers covered with glass tubes are inserted into the plasma. The glass tubes can be rotated in the poloidal and the toroidal directions. The new IDS system will be applied to observations of ion temperature and plasma rotation in the flipped ST formation and in the MHD control of kinking behaviors of the central column by using the rotating magnetic field (RMF). Preliminary IDS results will be compared to those from Mach probe measurements in space.

30-Day In-vivo Performance of a Wearable Artificial Pump-Lung for Ambulatory Respiratory Support

PubMed Central

Wu, Zhongjun J; Zhang, Tao; Bianchi, Giacomo; Wei, Xufeng; Son, Ho-Sung; Zhou, Kang; Sanchez, Pablo; Garcia, Jose; Griffith, Bartley P

2011-01-01

Background The purpose of this study was to evaluate the long-term in-vivo hemodynamics, gas transfer and biocompatibility of an integrated artificial pump-lung (APL) developed for ambulatory respiratory support. Methods The study was conducted in an ovine model by surgically placing the APL between the right atrium and pulmonary artery. Nine sheep were implanted. Heparin was infused as an anticoagulant. The device flow, gas transfer and plasma free hemoglobin (PFH) were measured daily. Hematological data, platelet activation and blood biochemistry were assessed twice a week. After 30 days, the sheep were euthanized for necropsy. The explanted devices were examined for gross thrombosis. Results Five sheep survived for 29 to 31 days and were electively terminated. Four sheep expired or were terminated early due to mechanical failure of IV lines or device. The APL devices in the five long-term animals were capable of delivering an oxygen transfer rate of 148±18 ml/min at a flow rate of 2.99±0.46 l/min with blood oxygen saturation of 96.7±1.3%. The device flow and oxygen transfer were stable over 30 days. The animals had normal end-organ functions except for surgery-related transient alteration in kidney function, liver function, and cell and tissue injury. There was no hemolysis. The device flow path and membrane surface were free of gross thrombus. Conclusions The APL exhibited the capability of providing respiratory support with excellent biocompatibility, long-term reliability and the potential for bridging to lung transplant. PMID:22115337

Point-of-care optical tool to detect early stage of hemorrhage and shock

NASA Astrophysics Data System (ADS)

Gurjar, Rajan S.; Riccardi, Suzannah L.; Johnson, Blair D.; Johnson, Christopher P.; Paradis, Norman A.; Joyner, Michael J.; Wolf, David E.

2014-02-01

There is a critical unmet clinical need for a device that can monitor and predict the onset of shock: hemorrhagic shock or bleeding to death, septic shock or systemic infection, and cardiogenic shock or blood flow and tissue oxygenation impairment due to heart attack. Together these represent 141 M patients per year. We have developed a monitor for shock based on measuring blood flow in peripheral (skin) capillary beds using diffuse correlation spectroscopy, a form of dynamic light scattering, and have demonstrated proof-of-principle both in pigs and humans. Our results show that skin blood flow measurement, either alone or in conjunction with other hemodynamic properties such as heart rate variability, pulse pressure variability, and tissue oxygenation, can meet this unmet need in a small self-contained patch-like device in conjunction with a hand-held processing unit. In this paper we describe and discuss the experimental work and the multivariate statistical analysis performed to demonstrate proof-of-principle of the concept.

Analyzing the value of monitoring duodenal mucosal perfusion using photoplethysmography.

PubMed

Fink, Mitchell P

2014-10-13

Photoplethysmography (PPG) is a technique that permits noninvasive measurement of changes in the volume of tissues. A novel device uses PPG to assess changes in duodenal mucosal perfusion. When tested in septic piglets, data obtained using this device correlate with the blood lactate concentration and duodenal serosal microvascular blood flow as measured with a laser Doppler flowmeter. This new PPG-based approach for continuously monitoring gut mucosal perfusion warrants further development, leading to prospective clinical trials in patients.

Empirical synchronized flow in oversaturated city traffic.

PubMed

Kerner, Boris S; Hemmerle, Peter; Koller, Micha; Hermanns, Gerhard; Klenov, Sergey L; Rehborn, Hubert; Schreckenberg, Michael

2014-09-01

Based on a study of anonymized GPS probe vehicle traces measured by personal navigation devices in vehicles randomly distributed in city traffic, empirical synchronized flow in oversaturated city traffic has been revealed. It turns out that real oversaturated city traffic resulting from speed breakdown in a city in most cases can be considered random spatiotemporal alternations between sequences of moving queues and synchronized flow patterns in which the moving queues do not occur.

Single-Shot Spectrally Resolved UV Rayleigh Scattering Measurements in High Speed Flow

NASA Technical Reports Server (NTRS)

Seasholtz, Richard G.

1996-01-01

A single-shot UV molecular Rayleigh scattering technique to measure velocity in high speed flow is described. The beam from an injection-seeded, frequency quadrupled Nd:YAG laser (266 nm) is focused to a line in a free air jet with velocities up to Mach 1.3. Rayleigh scattered light is imaged through a planar mirror Fabry-Perot interferometer onto a Charged Coupled Device (CCD) array detector. Some laser light is also simultaneously imaged through the Fabry-Perot to provide a frequency reference. Two velocity measurements are obtained from each image. Multiple-pulse data are also given. The Rayleigh scattering velocity data show good agreement with velocities calculated from isentropic flow relations.

Power generation systems and methods

NASA Technical Reports Server (NTRS)

Jones, Jack A. (Inventor); Chao, Yi (Inventor)

2011-01-01

A power generation system includes a plurality of submerged mechanical devices. Each device includes a pump that can be powered, in operation, by mechanical energy to output a pressurized output liquid flow in a conduit. Main output conduits are connected with the device conduits to combine pressurized output flows output from the submerged mechanical devices into a lower number of pressurized flows. These flows are delivered to a location remote of the submerged mechanical devices for power generation.

Evaluation of six oxygen concentrators.

PubMed Central

Johns, D P; Rochford, P D; Streeton, J A

1985-01-01

Examples of six oxygen concentrators (DeVO2, Dom 10, Econo 2, Hudson, Permox, and Roomate) were evaluated over a 9-28 day period to determine (1) the oxygen yield (% O2) over the flow range 1-4 l min-1; (2) 90% oxygen rise time (90% RT) from a cold start when they were operated at 2 l min-1; (3) accuracy and readability of the flow device; (4) static outlet pressure; (5) major components comprising the product gas (Hudson only); and (6) general characteristics. At an outlet flow of 2 l min-1 the mean % O2 generated by all models, except the Permox (which was lower, mean (SD) 90.5% (3.1%), were between 94% and 95% with a range of less than +/- 0.5%. The Dom 10, Econo 2, and Hudson consistently generated higher oxygen concentrations than the other models at flow rates greater than 2 l min-1. The 90% RT was less than 10.5 minutes for all models. Deviations of up to 22% were observed between predicted and measured flow rates in all models except the DeVO2, Hudson, and Permox. It was possible to set the orifice type flow devices fitted to the Permox and Roomate between indicated flow settings, resulting in cessation of flow. Spectral analysis of the output of one device showed that argon and oxygen were concentrated to similar extents, indicating that the maximal attainable oxygen yield for a molecular sieve concentrator is about 96%. PMID:4071455

Evaluation of six oxygen concentrators.

PubMed

Johns, D P; Rochford, P D; Streeton, J A

1985-11-01

Examples of six oxygen concentrators (DeVO2, Dom 10, Econo 2, Hudson, Permox, and Roomate) were evaluated over a 9-28 day period to determine (1) the oxygen yield (% O2) over the flow range 1-4 l min-1; (2) 90% oxygen rise time (90% RT) from a cold start when they were operated at 2 l min-1; (3) accuracy and readability of the flow device; (4) static outlet pressure; (5) major components comprising the product gas (Hudson only); and (6) general characteristics. At an outlet flow of 2 l min-1 the mean % O2 generated by all models, except the Permox (which was lower, mean (SD) 90.5% (3.1%), were between 94% and 95% with a range of less than +/- 0.5%. The Dom 10, Econo 2, and Hudson consistently generated higher oxygen concentrations than the other models at flow rates greater than 2 l min-1. The 90% RT was less than 10.5 minutes for all models. Deviations of up to 22% were observed between predicted and measured flow rates in all models except the DeVO2, Hudson, and Permox. It was possible to set the orifice type flow devices fitted to the Permox and Roomate between indicated flow settings, resulting in cessation of flow. Spectral analysis of the output of one device showed that argon and oxygen were concentrated to similar extents, indicating that the maximal attainable oxygen yield for a molecular sieve concentrator is about 96%.

[The development and utility of new uroflowmetry measurement by wearable airborne ultrasound Doppler system].

PubMed

Matsumoto, Seiji; Kakizaki, Hidehiro

2012-09-01

The conventional concept of uroflowmetry (UFM) is to equip the urine-receiving container like a toilet device (s) with various sensors. A UFM device based on an airborne ultrasound continuous wave Doppler system was developed to satisfy the need of measuring urinary flow anytime and anywhere in an easy, natural, and repeated manner. It is a non-contact, indirect measuring device that can be easily worn by the test subjects who urinate. The prototype of the new UFM device was used to collect urination data from normal adult volunteers. Data could be collected with the new UFM device, and the Doppler spectrum (urination pattern) could be evaluated in chronological order for each volunteer's urination. It was confirmed from the examination of effectiveness that there is a potential for the clinical application of the new device, but at the present stage it is not yet clinically applicable. The results obtained suggest that the device may greatly change the concept of urodynamics, depending on future progress. However, accuracy in collecting samples and analyzing data will have to be further improved using the latest engineering technology.

In-line pressure within a HOTLINE® Fluid Warmer, under various flow conditions.

PubMed

Higashi, Midoriko; Yamaura, Ken; Matsubara, Yukie; Fukudome, Takuya; Hoka, Sumio

2015-04-01

Roller pump infusion devices are widely used for rapid infusion, and may be combined with separate warming devices. There may be instances however, where the pressures generated by the roller pump may not be compatible with the warming device. We assessed a commonly used roller pump in combination with a HOTLINE® Fluid Warmer, and found that it could generate pressures exceeding the HOTLINE® manufacturers specifications. This was of concern because the HOTLINE® manufacturer guideline states that not for use with pressure devices generating over 300 mmHg. Pressure greater than 300 mmHg may compromise the integrity of the HOTLINE® Fluid Warming Set. The aim of this study was to compare in-line pressure within a HOTLINE® Fluid Warmer at different infusion rates of a roller pump using various sizes of intravenous cannulae. The rapid infusion system comprised a 500 mL-normal saline bag, roller pump type infusion device, HOTLINE® Fluid Warmer (blood and fluid warmer system), and six different sizes of intravenous cannulae. In-line pressure was measured proximal to the HOTLINE® (pre-warmer) and proximal to the cannula (post-warmer), at flow rate of 50-160 mL/min. The in-line pressures increased significantly with increasing flow rate. The pre-warmer pressures exceeded 300 mmHg when the flow rate was ≥120 mL/min with 20-gauge, 48 mm length cannula, 130 with 20-gauge, 25 mm cannula, and 160 mL/min with 18-gauge, 48 mm cannula. However, they were <300 mmHg at any flow rates with 18-gauge, 30 mm cannula and 16-gauge cannulae. The post-warmer pressures exceeded 300 mmHg at the flow rate of 140 mL/min with 20-gauge, 48 mm cannula, and 160 mL/min with 20-gauge, 25 mm cannula, while they were <300 mmHg at any flow rates with 18 and 16-gauge cannulae. The in-line pressure within a HOTLINE® could exceed 300 mmHg, depending on the flow rate and size and length of cannula. It is important to pay attention to the size and length of cannulae and flow rate to keep the maximum in-line pressure<300 mmHg when a roller pump type infusion device is used.

Development of a new instrument for direct skin friction measurements

NASA Technical Reports Server (NTRS)

Vakili, A. D.; Wu, J. M.

1986-01-01

A device developed for the direct measurement of wall shear stress generated by flows is described. Simple and symmetric in design with optional small moving mass and no internal friction, the features employed in the design eliminate most of the difficulties associated with the traditional floating element balances. The device is basically small and can be made in various sizes. Vibration problems associated with the floating element skin friction balances were found to be minimized due to the design symmetry and optional damping provided. The design eliminates or reduces the errors associated with conventional floating element devices: such as errors due to gaps, pressure gradient, acceleration, heat transfer, and temperature change. The instrument is equipped with various sensing systems and the output signal is a linear function of the wall shear stress. Dynamic measurements could be made in a limited range and measurements in liquids could be performed readily. Measurement made in the three different tunnels show excellent agreement with data obtained by the floating element devices and other techniques.

Culture and Sampling of Primary Adipose Tissue in Practical Microfluidic Systems.

PubMed

Brooks, Jessica C; Judd, Robert L; Easley, Christopher J

2017-01-01

Microfluidic culture of primary adipose tissue allows for reduced sample and reagent volumes as well as constant media perfusion of the cells. By continuously flowing media over the tissue, microfluidic sampling systems can more accurately mimic vascular flow in vivo. Quantitative measurements can be performed on or off chip to provide time-resolved secretion data, furthering insight into the dynamics of the function of adipose tissue. Buoyancy resulting from the large lipid storage capacity in this tissue presents a unique challenge for culture, and it is important to account for this buoyancy during microdevice design. Herein, we describe approaches for microfluidic device fabrication that utilize 3D-printed interface templating to help counteract cell buoyancy. We apply such methods to the culture of both isolated, dispersed primary adipocytes and epididymal adipose explants. To facilitate more widespread adoption of the methodology, the devices presented here are designed for user-friendly operation. Only handheld syringes are needed to control flow, and devices are inexpensive and disposable.

Assessment of volume and leak measurements during CPAP using a neonatal lung model.

PubMed

Fischer, H S; Roehr, C C; Proquitté, H; Wauer, R R; Schmalisch, G

2008-01-01

Although several commercial devices are available which allow tidal volume and air leak monitoring during continuous positive airway pressure (CPAP) in neonates, little is known about their measurement accuracy and about the influence of air leaks on volume measurement. The aim of this in vitro study was the validation of volume and leak measurement under CPAP using a commercial ventilatory device, taking into consideration the clinical conditions in neonatology. The measurement accuracy of the Leoni ventilator (Heinen & Löwenstein, Germany) was investigated both in a leak-free system and with leaks simulated using calibration syringes (2-10 ml, 20-100 ml) and a mechanical lung model. Open tubes of variable lengths were connected for leak simulation. Leak flow was measured with the flow-through technique. In a leak-free system the mean relative volume error +/-SD was 3.5 +/- 2.6% (2-10 ml) and 5.9 +/- 0.7% (20-60 ml), respectively. The influence of CPAP level, driving flow, respiratory rate and humidification of the breathing gas on the volume error was negligible. However, an increasing F(i)O(2) caused the measured tidal volume to increase by up to 25% (F(i)O(2) = 1.0). The relative error +/- SD of the leak measurements was -0.2 +/- 11.9%. For leaks > 19%, measured tidal volume was underestimated by more than 10%. In conclusion, the present in vitro study showed that the Leoni allowed accurate volume monitoring under CPAP conditions similar to neonates. Air leaks of up to 90% of patient flow were reliably detected. For an F(i)O(2) > 0.4 and for leaks > 19%, a numerical correction of the displayed volume should be performed.

End-diastolic fractional flow reserve: comparison with conventional full-cardiac cycle fractional flow reserve.

PubMed

Chalyan, David A; Zhang, Zhang; Takarada, Shigeho; Molloi, Sabee

2014-02-01

Diastolic fractional flow reserve (dFFR) has been shown to be highly sensitive for detection of inducible myocardial ischemia. However, its reliance on measurement of left-ventricular pressure for zero-flow pressure correction, as well as manual extraction of the diastolic interval, has been its major limitation. Given previous reports of minimal zero-flow pressure at end-diastole, we compared instantaneous ECG-gated end-diastolic FFR with conventional full-cardiac cycle FFR and other diastolic indices in the porcine model. Measurements of FFR in the left anterior descending and left circumflex arteries were performed in an open-chest swine model with an external occluder device on the coronary artery used to produce varying degrees of epicardial stenosis. An ultrasound flow-probe that was placed proximal to the occluder measured absolute blood flow in ml/min, and it was used as a gold standard for FFR measurement. A total of 17 measurements at maximal hyperemia were acquired in 5 animals. Correlation coefficient between conventional mean hyperemic FFR with pressure-wire and directly measured FFR with flow-probe was 0.876 (standard error estimate=0.069; P<0.0001). The hyperemic end-diastolic FFR with pressure-wire correlated better with FFR measured directly with flow-probe (r=0.941, standard error estimate=0.050; P<0.0001). Instantaneous hyperemic ECG-gated FFR acquired at end-diastole, as compared with conventional full-cardiac cycle FFR, has an improved correlation with FFR measured directly with ultrasound flow-probe.

Surfactant monitoring by foam generation

DOEpatents

Mullen, Ken I.

1997-01-01

A device for monitoring the presence or absence of active surfactant or other surface active agents in a solution or flowing stream based on the formation of foam or bubbles is presented. The device detects the formation of foam with a light beam or conductivity measurement. The height or density of the foam can be correlated to the concentration of the active surfactant present.

Flow control in a diffusing S-Duct

NASA Technical Reports Server (NTRS)

Vakili, A. D.; Wu, J. M.; Liver, P.; Bhat, M. K.

1985-01-01

Accurate measurements have been made of secondary flow in a 1.51 area ratio diffusing 30 deg - 30 deg S-Duct with circulair cross section. Turbulent flow was entering the duct at Mach number of 0.6, the boundary layer thickness at the duct entrance was ten percent of the duct inlet diameter. Through measurements made, local flow velocity vector as well as static and total pressures mapping of the flow at several stations were obtained. Strong secondary flow was measured in the first bend which continued into the second bend with new vorticity produced in there in the opposite direction. Surface oil flow visualization and wall pressures indicated a region of separated flow starting at theta approximately equal to 22 deg on the inside of the first bend up to theta approximately equal to 44 deg on the outside of the second bend. The flow separated in 'cyclone' form and never reattached in the duct. As a result of the secondary flow and the flow separation, significant total pressure distortion was observed at the exit of the duct. Using flow control devices the separation was eliminated while the exit distortion was improved.

Heat Generation in Axial and Centrifugal Flow Left Ventricular Assist Devices.

PubMed

Yost, Gardner; Joseph, Christine Rachel; Royston, Thomas; Tatooles, Antone; Bhat, Geetha

Despite increasing use of left ventricular assist devices (LVADs) as a surgical treatment for advanced heart failure in an era of improved outcomes with LVAD support, the mechanical interactions between these pumps and the cardiovascular system are not completely understood. We utilized an in vitro mock circulatory loop to analyze the heat production incurred by operation of an axial flow and centrifugal flow LVAD. A HeartMate II and a HeartWare HVAD were connected to an abbreviated flow loop and were implanted in a viscoelastic gel. Temperature was measured at the surface of each LVAD. Device speed and fluid viscosity were altered and, in the HeartMate II, as artificial thrombi were attached to the inflow stator, impeller, and outflow stator. The surface temperatures of both LVADs increased in all trials and reached a plateau within 80 minutes of flow initiation. Rate of heat generation and maximum system temperature were greater when speed was increased, when viscosity was increased, and when artificial thrombi were attached to the HeartMate II impeller. Normal operation of these two widely utilized LVADs results in appreciable heat generation in vitro. Increased pump loading resulted in more rapid heat generation, which was particularly severe when a large thrombus was attached to the impeller of the HeartMate II. While heat accumulation in vivo is likely minimized by greater dissipation in the blood and soft tissues, focal temperature gains with the pump housing of these two devices during long-term operation may have negative hematological consequences.

Diode laser absorption sensors for gas-dynamic and combustion flows

NASA Technical Reports Server (NTRS)

Allen, M. G.

1998-01-01

Recent advances in room-temperature, near-IR and visible diode laser sources for tele-communication, high-speed computer networks, and optical data storage applications are enabling a new generation of gas-dynamic and combustion-flow sensors based on laser absorption spectroscopy. In addition to conventional species concentration and density measurements, spectroscopic techniques for temperature, velocity, pressure and mass flux have been demonstrated in laboratory, industrial and technical flows. Combined with fibreoptic distribution networks and ultrasensitive detection strategies, compact and portable sensors are now appearing for a variety of applications. In many cases, the superior spectroscopic quality of the new laser sources compared with earlier cryogenic, mid-IR devices is allowing increased sensitivity of trace species measurements, high-precision spectroscopy of major gas constituents, and stable, autonomous measurement systems. The purpose of this article is to review recent progress in this field and suggest likely directions for future research and development. The various laser-source technologies are briefly reviewed as they relate to sensor applications. Basic theory for laser absorption measurements of gas-dynamic properties is reviewed and special detection strategies for the weak near-IR and visible absorption spectra are described. Typical sensor configurations are described and compared for various application scenarios, ranging from laboratory research to automated field and airborne packages. Recent applications of gas-dynamic sensors for air flows and fluxes of trace atmospheric species are presented. Applications of gas-dynamic and combustion sensors to research and development of high-speed flows aeropropulsion engines, and combustion emissions monitoring are presented in detail, along with emerging flow control systems based on these new sensors. Finally, technology in nonlinear frequency conversion, UV laser materials, room-temperature mid-IR materials and broadly tunable multisection devices is reviewed to suggest new sensor possibilities.

Breathing simulator of workers for respirator performance test.

PubMed

Yuasa, Hisashi; Kumita, Mikio; Honda, Takeshi; Kimura, Kazushi; Nozaki, Kosuke; Emi, Hitoshi; Otani, Yoshio

2015-01-01

Breathing machines are widely used to evaluate respirator performance but they are capable of generating only limited air flow patterns, such as, sine, triangular and square waves. In order to evaluate the respirator performance in practical use, it is desirable to test the respirator using the actual breathing patterns of wearers. However, it has been a difficult task for a breathing machine to generate such complicated flow patterns, since the human respiratory volume changes depending on the human activities and workload. In this study, we have developed an electromechanical breathing simulator and a respiration sampling device to record and reproduce worker's respiration. It is capable of generating various flow patterns by inputting breathing pattern signals recorded by a computer, as well as the fixed air flow patterns. The device is equipped with a self-control program to compensate the difference in inhalation and exhalation volume and the measurement errors on the breathing flow rate. The system was successfully applied to record the breathing patterns of workers engaging in welding and reproduced the breathing patterns.

A Galloping Energy Harvester with Attached Flow

NASA Astrophysics Data System (ADS)

Denissenko, Petr; Khovanov, Igor; Tucker-Harvey, Sam

2017-11-01

Aeroelastic energy harvesters are a promising technology for the operation of wireless sensors and microelectromechanical systems, as well as providing the possibility of harvesting wind energy in applications were conventional wind turbines are ineffective, such as in highly turbulent flows, or unreliable, such as in harsh environmental conditions. The development of aeroelastic energy harvesters to date has focused on the flutter of airfoils, the galloping of prismatic structures, and the vortex induced vibrations. We present a novel type of galloping energy harvester with the flow becoming attached when the oscillation amplitude is high enough. With the flow attached, the harvester blade acts closer to an aerofoil than a bluff body, which results in a higher efficiency. The dynamics of a prototype device has been characterised experimentally with the use of a motion tracking system. The flow structure in the vicinity of the device has been studied using smoke visualisation and PIV measurements. A lumped parameter mathematical model has been developed and related to the experimental results.

Multiphase flow simulations of a moving fluidized bed regenerator in a carbon capture unit

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sarkar, Avik; Pan, Wenxiao; Suh, Dong-Myung

2014-10-01

To accelerate the commercialization and deployment of carbon capture technologies, computational fluid dynamics (CFD)-based tools may be used to model and analyze the performance of carbon capture devices. This work presents multiphase CFD-based flow simulations for the regeneration device responsible for extracting CO 2 from CO 2-loaded sorbent particles before the particles are recycled. The use of solid particle sorbents in this design is a departure from previously reported systems, where aqueous sorbents are employed. Another new feature is the inclusion of a series of perforated plates along the regenerator height. The influence of these plates on sorbent distribution ismore » examined for varying sorbent holdup, fluidizing gas velocity, and particle size. The residence time distribution of sorbents is also measured to classify the low regime as plug flow or well-mixed flow. The purpose of this work is to better understand the sorbent flow characteristics before reaction kinetics of CO 2 desorption can be implemented.« less

An Inexpensive, Fast and Sensitive Quantitative Lateral Flow Magneto-Immunoassay for Total Prostate Specific Antigen

PubMed Central

Barnett, Jacqueline M.; Wraith, Patrick; Kiely, Janice; Persad, Raj; Hurley, Katrina; Hawkins, Peter; Luxton, Richard

2014-01-01

We describe the detection characteristics of a device the Resonant Coil Magnetometer (RCM) to quantify paramagnetic particles (PMPs) in immunochromatographic (lateral flow) assays. Lateral flow assays were developed using PMPs for the measurement of total prostate specific antigen (PSA) in serum samples. A detection limit of 0.8 ng/mL was achieved for total PSA using the RCM and is at clinically significant concentrations. Comparison of data obtained in a pilot study from the analysis of serum samples with commercially available immunoassays shows good agreement. The development of a quantitative magneto-immunoassay in lateral flow format for total PSA suggests the potential of the RCM to operate with many immunoassay formats. The RCM has the potential to be modified to quantify multiple analytes in this format. This research shows promise for the development of an inexpensive device capable of quantifying multiple analytes at the point-of-care using a magneto-immunoassay in lateral flow format. PMID:25587419

Correcting for particle counting bias error in turbulent flow

NASA Technical Reports Server (NTRS)

Edwards, R. V.; Baratuci, W.

1985-01-01

An ideal seeding device is proposed generating particles that exactly follow the flow out are still a major source of error, i.e., with a particle counting bias wherein the probability of measuring velocity is a function of velocity. The error in the measured mean can be as much as 25%. Many schemes have been put forward to correct for this error, but there is not universal agreement as to the acceptability of any one method. In particular it is sometimes difficult to know if the assumptions required in the analysis are fulfilled by any particular flow measurement system. To check various correction mechanisms in an ideal way and to gain some insight into how to correct with the fewest initial assumptions, a computer simulation is constructed to simulate laser anemometer measurements in a turbulent flow. That simulator and the results of its use are discussed.

Acute Hemodynamic Effects of the Braslet-M Device on the International Space Station

NASA Technical Reports Server (NTRS)

Hamilton, Douglas R.; Barratt, Michael R.; Sargsyan, Ashot E.; Garcia, Kathleen M.; Ebert, Douglas; Martin, David; Dulchavsky, Scott A.; Duncan, J. Michael

2009-01-01

The Braslet-M occlusion device is prescribed for cosmonauts as a countermeasure for early phases of spaceflight to temporarily alleviate symptoms associated with the cephalad fluid shift. Using a multipurpose ultrasound (US) device onboard, we assessed the acute hemodynamic effects of the Bracelet-M device on a long duration International Space Station (ISS) crewmember. Methods A combination of just-in-time training and real-time remote expert assistance was used to conduct the imaging procedures. An HDI-5000 imager (Philips, Bothell, WA) was used, provided by the ISS Human Research Facility. Superficial femoral artery (SFA), femoral vein (FV) flow spectra were obtained at mid-thigh level. Left ventricle was imaged through the apical 4-chamber view, with Color M-Mode to measure propagation velocity (V (p)). After 10 minutes of Bracelet-M use, data collection was repeated. All data were transmitted in DICOM format to ground for analysis. Results With Braslet-M, cardiac V(p) slope decreased (56ms to 42ms). A stagnation signature in the FV was seen suggesting impeded flow (rouleaux formation, too-low-to-measure velocity, and increase in diameter). Quadri-phasic flow in SFA was seen both before and after Braslet-M application. Velocities in the SFA decreased with Braslet-M (65cm/sec to 52cm/sec) and so did the time velocity integrals (16.97 to 12.4); the flow pattern spoke of resistivity increase in the vascular bed. Conclusion In the long duration ISS crewmember we observed effects of lower extremity venous occlusion through both central and peripheral indicators. A part of circulating volume transferred to peripheral potential vascular space. Impediment to venous outflow was demonstrated objectively, with a commensurate change in the flow pattern of the main feeding artery. Central volume reduction caused lower V(p). Additional studies are warranted to determine the time course of the changes and the dynamics in interstitial fluid sequestration, as well as the safe levels and duration of the compression forces.

Role of poloidal flows on the particle confinement time in a simple toroidal device : an experimental study

NASA Astrophysics Data System (ADS)

Kumar, Umesh; Ganesh, R.; Saxena, Y. C.; Thatipamula, Shekar G.; Sathyanarayana, K.; Raju, Daniel

2017-10-01

In magnetized toroidal devices without rotational transform also known as Simple Magnetized Torus (SMT). The device BETA at the IPR is one such SMT with a major radius of 45 cm, minor radius of 15 cm and a maximum toroidal field of 0.1 Tesla. Understanding confinement in such helical configurations is an important problem both for fundamental plasma physics and for Tokamak edge physics. In a recent series of experiments it was demonstrated experimentally that the mean plasma profiles, fluctuation, flow and turbulence depend crucially on the parallel connection length, which was controlled by external vertical field. In the present work, we report our experimental findings, wherein we measure the particle confinement time for hot cathode discharge and ECRH discharge, with variation in parallel connection length. As ECRH plasma don't have mean electric field and hence the poloidal rotation of plasma is absent. However, in hot cathode discharge, there exist strong poloidal flows due to mean electric field. An experimental comparison of these along with theoretical model with variation in connection length will be presented. We also present experimental measurements of variation of plasma confinement time with mass as well as the ratio of vertical field to toroidal magnetic field.

Programmable electrochemical flow system for high throughput determination of total antioxidant capacity.

PubMed

Veenuttranon, Kornautchaya; Nguyen, Loc Thai

2018-08-15

The aim of this work was to develop a programmable flow system for rapid assessment of total antioxidant capacity (TAC). Novel features of the prototype include a single pressure-driven source, versatile manipulation of fluid flows, ability to adapt to different TAC assays, and compatibility with microfluidic design. Antioxidant activity was determined by electrochemical measurement of residual 2,2-diphenyl-2-picrylhydrayl hydrate (DPPH•) free radicals in the solution. The overall performance of the device was validated by the spectrophotometric method. The results indicated that dosing of reagents and samples could be controlled by pressure (R 2 = 0.992) and time (R 2 = 0.999) with high accuracy, and the mixing uniformity of the device was equivalent to that of the batch mixing (R 2 = 0.994). TAC assays of a standard antioxidant, ascorbic acid, as well as selected samples such as orange and pomegranate juices, white wine, and green tea by the device were comparable to traditional measurement techniques. Due to the short incubation time, the approach may be more suitable for fast, rather than slow reacting antioxidant compounds. The developed system could be used for rapid TAC screening of food and biological samples. Copyright © 2018 Elsevier B.V. All rights reserved.

The influence of flow modification on air and PCM temperatures in an accumulative heat exchanger

NASA Astrophysics Data System (ADS)

Borcuch, Marcin; Musiał, Michał; Sztekler, Karol; Kalawa, Wojciech; Gumuła, Stanisław; Stefański, Sebastian

2018-06-01

The paper presents the influence of flow modification on the operation of an accumulative heat exchanger. This device can be used as a regenerator in ventilation and air supply systems. A heat exchanger uses ceresine (a mixture of paraffins) as a phase change material (PCM). The aim of this research was to determine the effect of flow modification on temperature distribution and pressure drops in the device. The introduction contains a short description of the test stand used, including the accumulative heat exchanger, the guide vanes, and the locations of measurement and control equipment. We found that additional objects limited vortex structures, increased the inside temperature, and dropped the pressure along the heat exchanger. Guidelines for further research are proposed and briefly discussed.

Simultaneous Moisture Content and Mass Flow Measurements in Wood Chip Flows Using Coupled Dielectric and Impact Sensors.

PubMed

Pan, Pengmin; McDonald, Timothy; Fulton, John; Via, Brian; Hung, John

2016-12-23

An 8-electrode capacitance tomography (ECT) sensor was built and used to measure moisture content (MC) and mass flow of pine chip flows. The device was capable of directly measuring total water quantity in a sample but was sensitive to both dry matter and moisture, and therefore required a second measurement of mass flow to calculate MC. Two means of calculating the mass flow were used: the first being an impact sensor to measure total mass flow, and the second a volumetric approach based on measuring total area occupied by wood in images generated using the capacitance sensor's tomographic mode. Tests were made on 109 groups of wood chips ranging in moisture content from 14% to 120% (dry basis) and wet weight of 280 to 1100 g. Sixty groups were randomly selected as a calibration set, and the remaining were used for validation of the sensor's performance. For the combined capacitance/force transducer system, root mean square errors of prediction (RMSEP) for wet mass flow and moisture content were 13.42% and 16.61%, respectively. RMSEP using the combined volumetric mass flow/capacitance sensor for dry mass flow and moisture content were 22.89% and 24.16%, respectively. Either of the approaches was concluded to be feasible for prediction of moisture content in pine chip flows, but combining the impact and capacitance sensors was easier to implement. In situations where flows could not be impeded, however, the tomographic approach would likely be more useful.

Pilot study of a new device to titrate oxygen flow in hypoxic patients on long-term oxygen therapy.

PubMed

Cirio, Serena; Nava, Stefano

2011-04-01

The O(2) Flow Regulator (Dima, Bologna, Italy) is a new automated oxygen regulator that titrates the oxygen flow based on a pulse-oximetry signal to maintain a target S(pO(2)). We tested the device's safety and efficacy. We enrolled 18 subjects with chronic lung disease, exercise-induced desaturation, and on long-term oxygen therapy, in a randomized crossover study with 2 constant-work-load 15-min cycling exercise tests, starting with the patient's previously prescribed usual oxygen flow. In one test the oxygen flow was titrated manually by the respiratory therapist, and in the other test the oxygen flow was titrated by the O(2) Flow Regulator, to maintain an S(pO(2)) of 94%. We measured S(pO(2)) throughout each test, the time spent by the respiratory therapist to set the device or to manually regulate the oxygen flow, and the total number of respiratory-therapist titration interventions during the trial. There were no differences in symptoms or heart rate between the exercise tests. Compared to the respiratory-therapist-controlled tests, during the O(2) Flow Regulator tests S(pO(2)) was significantly higher (95 ± 2% vs 93 ± 3%, P = .04), significantly less time was spent below the target S(pO(2)) (171 ± 187 s vs 340 ± 220 s, P < .001), and the O(2) Flow Regulator tests required significantly less respiratory therapist time (5.6 ± 3.7 min vs 2.0 ± 0.1 min, P = .005). The O(2) Flow Regulator may be a safe and effective alternative to manual oxygen titration during exercise in hypoxic patients. It provided stable S(pO(2)) and avoided desaturations in our subjects.

Device for precision measurement of speed of sound in a gas

DOEpatents

Kelner, Eric; Minachi, Ali; Owen, Thomas E.; Burzynski, Jr., Marion; Petullo, Steven P.

2004-11-30

A sensor for measuring the speed of sound in a gas. The sensor has a helical coil, through which the gas flows before entering an inner chamber. Flow through the coil brings the gas into thermal equilibrium with the test chamber body. After the gas enters the chamber, a transducer produces an ultrasonic pulse, which is reflected from each of two faces of a target. The time difference between the two reflected signals is used to determine the speed of sound in the gas.

Evaluation of Pressure Generated by Resistors From Different Positive Expiratory Pressure Devices.

PubMed

Fagevik Olsén, Monika; Carlsson, Maria; Olsén, Erik; Westerdahl, Elisabeth

2015-10-01

Breathing exercises with positive expiratory pressure (PEP) are used to improve pulmonary function and airway clearance. Different PEP devices are available, but there have been no studies that describe the pressure generated by different resistors. The purpose of this study was to compare pressures generated from the proprietary resistor components of 4 commercial flow-dependent PEP valves with all other parameters kept constant. Resistors from 4 flow-regulated PEP devices (Pep/Rmt system, Wellspect HealthCare; Pipe P breathing exerciser, Koo Medical Equipment; Mini-PEP, Philips Respironics [including resistors by Rüsch]; and 15-mm endo-adapter, VBM Medizintechnik) were tested randomly by a blinded tester at constant flows of 10 and 18 L/min from an external gas system. All resistors were tested 3 times. Resistors with a similar diameter produced statistically significant different pressures at the same flow. The differences were smaller when the flow was 10 L/min compared with 18 L/min. The differences were also smaller when the diameter of the resistor was increased. The pressures produced by the 4 resistors of the same size were all significantly different when measuring 1.5- and 2.0-mm resistors at a flow of 10 L/min and 2.0-mm resistors at a flow of 18 L/min (P < .001). There were no significant differences between any of the resistors when testing sizes of 4.5 and 5.0 mm at either flow. The Mini-PEP and adapter resistors gave the highest pressures. Pressures generated by the different proprietary resistor components of 4 commercial PEP devices were not comparable, even though the diameter of the resistors is reported to be the same. The pressures generated were significantly different, particularly when using small-diameter resistors at a high flow. Therefore, the resistors may not be interchangeable. This is important information for clinicians, particularly when considering PEP for patients who do not tolerate higher pressures. Copyright © 2015 by Daedalus Enterprises.

Flow cytometry: basic principles and applications.

PubMed

Adan, Aysun; Alizada, Günel; Kiraz, Yağmur; Baran, Yusuf; Nalbant, Ayten

2017-03-01

Flow cytometry is a sophisticated instrument measuring multiple physical characteristics of a single cell such as size and granularity simultaneously as the cell flows in suspension through a measuring device. Its working depends on the light scattering features of the cells under investigation, which may be derived from dyes or monoclonal antibodies targeting either extracellular molecules located on the surface or intracellular molecules inside the cell. This approach makes flow cytometry a powerful tool for detailed analysis of complex populations in a short period of time. This review covers the general principles and selected applications of flow cytometry such as immunophenotyping of peripheral blood cells, analysis of apoptosis and detection of cytokines. Additionally, this report provides a basic understanding of flow cytometry technology essential for all users as well as the methods used to analyze and interpret the data. Moreover, recent progresses in flow cytometry have been discussed in order to give an opinion about the future importance of this technology.

Probe for production and measurement of acute mitral regurgitant flow in dog.

PubMed

Kléber, A G; Simon, R; Rutishauser, W

1976-02-01

A probe for production and measurement of acute mitral regurgitation in dogs is described. It consists of a tube that is introduced into the mitral valve through the left atrial appendage. Regurgitant flow through the tube is measured by an electromagnetic device. Variation of flow and zero flow are achieved by narrowing or occluding the tube with a rubber cuff. In animals weighing 30-50 kg, the probe does not produce significant mitral stenosis and the mitral leaflets fit closely around the probe during ventricular systole. The instantaneous relationship between mitral regurgitant flow (MRF) and the gradient between left ventricular and left atrial pressure shows a marked delay of MRF at the beginning and end of regurgitation. This delay can be attributed to some extent to electrical phase lag and to the small movement of the probe relative to the mitral valve during the cardiac cycle. Measurement of regurgitant stroke volume is affected by this movement only to a small extent.

Momentum rate probe for use with two-phase flows

NASA Astrophysics Data System (ADS)

Bush, S. G.; Bennett, J. B.; Sojka, P. E.; Panchagnula, M. V.; Plesniak, M. W.

1996-05-01

An instrument for measuring the momentum rate of two-phase flows is described, and design and construction details are provided. The device utilizes a conelike body to turn the flow from the axial to the radial direction. The force resulting from the change in momentum rate of the turning flow is measured using a strain-gage-instrumented cantilevered beam. The instrument is applicable to a wide range of flows including nuclear reactor coolant streams, refrigerants in heating-ventilating air-conditioning equipment, impingement cooling of small scale electronic hardware (computer chips are one example), supercritical fuel injection (in Diesel engines, for instance), and consumer product sprays (such as hair-care product sprays produced using effervescent atomizers). The latter application is discussed here. Features of the instrument include sensitivity to a wide range of forces and the ability to damp oscillations of the deflection cone. Instrument sensitivity allows measurement of momentum rates considerably lower (below 0.01 N) than those that could be obtained using previous devices. This feature is a direct result of our use of precision strain gages, capable of sensing strains below 20 μm/m, and the damping of oscillations which can overwhelm the force measurements. Oscillation damping results from a viscous fluid damper whose resistance is easily varied by changing fluids. Data used to calibrate the instrument are presented to demonstrate the effectiveness of the technique. As an example of the instrument's utility, momentum rate data obtained using it will be valuable in efforts to explain entrainment of surrounding air into effervescent atomizer-produced sprays and also to model the effervescent atomization process.

Mathematical and physical model of gravity-fed infusion outflow: application to soft-bag-packed solutions.

PubMed

Simon, N; Décaudin, B; Lannoy, D; Barthélémy, C; Lemdani, M; Odou, P

2011-12-01

Gravity-fed infusion (GFI) systems are acknowledged as being unable to keep their flow-rate constant. This may affect drug plasma levels such as aminoglycosides. Numerous factors have previously been cited, but their relative importance has never been quantified so far. The objective of this work is to identify the main factors that influence GFI in vitro outflow and to propose a mathematical model of flow-rate evolution as a function of time. In this model, pressure loss and infusion device creep have been considered as the main variation factors. Concomitantly, two experiments were undertaken. Firstly, the flow-rate evolution of an in vitro infusion of 250 mL of dextrose 5% was assessed. Secondly, the creep occurring on an infusion device was measured through a stress relaxation experiment. The experimental infusion flow-rate decreased by as much as 28.5% over 1 h. Simulated and experimental data are well correlated (r = 0.987; P < 0.0001). The maximum creep effect happens during the first 15 min of infusion. In this work, height of the liquid in the bag and tube creep were found to be the main variation factors in GFI flow-rate. This new mathematical model should help to explain the differences observed in drug plasma levels with gravity-fed devices.

Left ventricular diastolic filling with an implantable ventricular assist device: beat to beat variability with overall improvement

NASA Technical Reports Server (NTRS)

Nakatani, S.; Thomas, J. D.; Vandervoort, P. M.; Zhou, J.; Greenberg, N. L.; Savage, R. M.; McCarthy, P. M.

1997-01-01

OBJECTIVES: We studied the effects of left ventricular (LV) unloading by an implantable ventricular assist device on LV diastolic filling. BACKGROUND: Although many investigators have reported reliable systemic and peripheral circulatory support with implantable LV assist devices, little is known about their effect on cardiac performance. METHODS: Peak velocities of early diastolic filling, late diastolic filling, late to early filling ratio, deceleration time of early filling, diastolic filling period and atrial filling fraction were measured by intraoperative transesophageal Doppler echocardiography before and after insertion of an LV assist device in eight patients. A numerical model was developed to simulate this situation. RESULTS: Before device insertion, all patients showed either a restrictive or a monophasic transmitral flow pattern. After device insertion, transmitral flow showed rapid beat to beat variation in each patient, from abnormal relaxation to restrictive patterns. However, when the average values obtained from 10 consecutive beats were considered, overall filling was significantly normalized from baseline, with early filling velocity falling from 87 +/- 31 to 64 +/- 26 cm/s (p < 0.01) and late filling velocity rising from 8 +/- 11 to 32 +/- 23 cm/s (p < 0.05), resulting in an increase in the late to early filling ratio from 0.13 +/- 0.18 to 0.59 +/- 0.38 (p < 0.01) and a rise in the atrial filling fraction from 8 +/- 10% to 26 +/- 17% (p < 0.01). The deceleration time (from 112 +/- 40 to 160 +/- 44 ms, p < 0.05) and the filling period corrected by the RR interval (from 39 +/- 8% to 54 +/- 10%, p < 0.005) were also significantly prolonged. In the computer model, asynchronous LV assistance produced significant beat to beat variation in filling indexes, but overall a normalization of deceleration time as well as other variables. CONCLUSIONS: With LV assistance, transmitral flow showed rapidly varying patterns beat by beat in each patient, but overall diastolic filling tended to normalize with an increase of atrial contribution to the filling. Because of the variable nature of the transmitral flow pattern with the assist device, the timing of the device cycle must be considered when inferring diastolic function from transmitral flow pattern.

Choroidal microcirculation in patients with rotary cardiac assist device.

PubMed

Polska, Elzbieta; Schima, Heinrich; Wieselthaler, Georg; Schmetterer, Leopold

2007-06-01

In recent years, fully implanted rotary blood pumps have been used for long-term cardiac assist in patients with end-stage heart failure. With these pumps, the pulsatility of arterial blood flow and arterial pressure pulse is considerably reduced. Effects on end-organ perfusion, particularly microcirculation, have been assessed. The ocular choroid offers a unique opportunity to study the pulsatile component of blood flow by measurement of fundus pulsation amplitude (FPA) as well as the microcirculation by laser Doppler flowmetry. Both techniques were applied in three male patients with rotary pumps (MicroMed DeBakey VAD), in whom pump velocity was adjusted to four levels of flow between individual minimal need and maximal support. In addition, blood flow velocities in the ophthalmic artery (peak, end-diastolic and mean flow velocity--PSV, EDV and MFV, respectively) were measured using color Doppler imaging. Systolic blood pressure increased by 6 to 22 mm Hg with increasing support. At maximal support FPA was reduced by -60% to -52% as compared with minimal pump support. Blood flow in the choroidal microvasculature, however, did not show relevant changes. A reduction in PSV (-31%, range -47% to -21%) and a pronounced rise in EDV (+93%, range +28% to +147%) was observed, whereas MFV was independent of pump flow. Our data indicate that mean choroidal blood flow is maintained when pump support is varied within therapeutic values, whereas the ratio of pulsatile to non-pulsatile choroidal flow changes. This study shows that, in patients with ventricular assist devices, a normal perfusion rate in the ocular microcirculation is maintained over a wide range of support conditions.

Efficacy of Cruise Control in controlling postocclusion surge with Legacy and Millennium venturi phacoemulsification machines.

PubMed

Wade, Matthew; Isom, Ryan; Georgescu, Dan; Olson, Randall J

2007-06-01

To determine the efficacy of the Cruise Control surge-limiting device (Staar Surgical) with phacoemulsification machines known to have high levels of surge. John A. Moran Eye Center Clinical Laboratories. In an in vitro study, postocclusion anterior chamber depth changes were measured in fresh phakic human eye-bank eyes using the Alcon Legacy and Bausch & Lomb Millennium venturi machines in conjunction with the Staar Cruise Control device. Both machines were tested with 19-gauge non-Aspiration Bypass System tips at high-surge settings (500 mm Hg vacuum pressure, 75 cm bottle height, 40 mL/min flow rate for the Legacy) and low-surge settings (400 mm Hg vacuum pressure, 125 cm bottle height, 40 mL/min flow rate for the Legacy). Adjusted parameters of flow, vacuum, and irrigation were used based on previous studies to create identical conditions for each device tested. The effect of the Cruise Control device on aspiration rates was also tested with both machines at the low-surge settings. At the high setting with the addition of Cruise Control, surge decreased significantly with the Legacy but was too large to measure with the Millennium venturi. At the low setting with the addition of Cruise Control, surge decreased significantly with both machines. Surge with the Millennium decreased from more than 1.0 mm to a mean of 0.21 mm +/- 0.02 (SD) (P<.0001). Surge with the Legacy decreased from a mean of 0.09 +/- 0.02 mm to 0.05 +/- 0 mm, a 42.9% decrease (P<.0001). The Millennium had the highest surge and aspiration rate before Cruise Control and the greatest percentage decrease in the surge and aspiration rates as a result of the addition of Cruise Control. In the Legacy machine, the Cruise Control device had a statistically and clinically significant effect. Cruise Control had a large effect on fluidics as well as surge amplitude with the Millennium machine. The greater the flow or greater the initial surge, the greater the impact of the Cruise Control device.

Experimental and numerical studies of a microfluidic device with compliant chambers for flow stabilization

NASA Astrophysics Data System (ADS)

Iyer, V.; Raj, A.; Annabattula, R. K.; Sen, A. K.

2015-07-01

This paper reports experimental and numerical studies of a passive microfluidic device that stabilizes a pulsating incoming flow and delivers a steady flow at the outlet. The device employs a series of chambers along the flow direction with a thin polymeric membrane (of thickness 75-250 µm) serving as the compliant boundary. The deformation of the membrane allows accumulation of fluid during an overflow and discharge of fluid during an underflow for flow stabilization. Coupled fluid-structure simulations are performed using Mooney-Rivlin formulations to account for a thin hyperelastic membrane material undergoing large deformations to accurately predict the device performance. The device was fabricated with PDMS as the substrate material and thin PDMS membrane as the compliant boundary. The performance of the device is defined in terms of a parameter called ‘Attenuation Factor (AF)’. The effect of various design parameters including membrane thickness, elastic modulus, chamber size and number of chambers in series as well as operating conditions including the outlet pressure, mean input flow rate, fluctuation amplitude and frequency on the device performance were studied using experiments and simulations. The simulation results successfully confront the experimental data (within 10%) which validates the numerical simulations. The device was used at the exit of a PZT actuated valveless micropump to take pulsating flow at the upstream and deliver steady flow downstream. The amplitude of the pulsating flow delivered by the micropump was significantly reduced (AF = 0.05 for a device with three 4 mm chambers) but at the expense of a reduction in the pressure capability (<20%). The proposed device could potentially be used for reducing flow pulsations in practical microfluidic circuits.

Blood clots are rapidly assembled hemodynamic sensors: flow arrest triggers intraluminal thrombus contraction.

PubMed

Muthard, Ryan W; Diamond, Scott L

2012-12-01

Blood clots form under flow during intravascular thrombosis or vessel leakage. Prevailing hemodynamics influence thrombus structure and may regulate contraction processes. A microfluidic device capable of flowing human blood over a side channel plugged with collagen (± tissue factor) was used to measure thrombus permeability (κ) and contraction at controlled transthrombus pressure drops. The collagen (κ(collagen)=1.98 × 10(-11) cm(2)) supported formation of a 20-µm thick platelet layer, which unexpectedly underwent massive platelet retraction on flow arrest. This contraction resulted in a 5.34-fold increase in permeability because of collagen restructuring. Without stopping flow, platelet deposits (no fibrin) had a permeability of κ(platelet)=5.45 × 10(-14) cm(2) and platelet-fibrin thrombi had κ(thrombus)=2.71 × 10(-14) cm(2) for ΔP=20.7 to 23.4 mm Hg, the first ever measurements for clots formed under arterial flow (1130 s(-1) wall shear rate). Platelet sensing of flow cessation triggered a 4.6- to 6.5-fold (n=3, P<0.05) increase in contraction rate, which was also observed in a rigid, impermeable parallel-plate microfluidic device. This triggered contraction was blocked by the myosin IIA inhibitor blebbistatin and by inhibitors of thromboxane A2 (TXA(2)) and ADP signaling. In addition, flow arrest triggered platelet intracellular calcium mobilization, which was blocked by TXA(2)/ADP inhibitors. As clots become occlusive or blood pools following vessel leakage, the flow diminishes, consequently allowing full platelet retraction. Flow dilution of ADP and thromboxane regulates platelet contractility with prevailing hemodynamics, a newly defined flow-sensing mechanism to regulate clot function.

Blood clots are rapidly assembled hemodynamic sensors: Flow arrest triggers intraluminal thrombus contraction

PubMed Central

Muthard, Ryan W.; Diamond, Scott L.

2012-01-01

Objective Blood clots form under flow during intravascular thrombosis or vessel leakage. Prevailing hemodynamics influence thrombus structure and may regulate contraction processes. A microfluidic device capable of flowing human blood over a side channel plugged with collagen (± tissue factor) was used to measure thrombus permeability (κ) and contraction at controlled transthrombus pressure drops. Methods and Results The collagen (κcollagen = 1.98 × 10−11 cm2) supported formation of a 20-μm thick platelet layer, which unexpectedly underwent massive platelet retraction upon flow arrest. This contraction resulted in a 5.34-fold increase in permeability due to collagen restructuring. Without stopping flow, platelet deposits (no fibrin) had a permeability of κplatelet = 5.45 × 10−14 cm2 and platelet-fibrin thrombi had κthrombus = 2.71 × 10−14 cm2 for ΔP = 20.7 to 23.4 mm-Hg, the first ever measurements for clots formed under arterial flow (1130 s−1 wall shear rate). Platelet sensing of flow cessation triggered a 4.6 to 6.5-fold (n=3, P<0.05) increase in contraction rate, which was also observed in a rigid, impermeable parallel-plate microfluidic device. This triggered contraction was blocked by the myosin IIA inhibitor blebbistatin and by inhibitors of thromboxane (TXA2) and ADP signaling. In addition, flow arrest triggered platelet intracellular calcium mobilization, which was blocked by TXA2/ADP inhibitors. As clots become occlusive or vessels rupture, flow around developed clots diminishes facilitating full platelet retraction and hemostasis. Conclusion Flow dilution of ADP and thromboxane regulates platelet contractility with prevailing hemodynamics, a newly defined flow sensing mechanism to regulate clot function. PMID:23087356

Laboratory Plasma Source as an MHD Model for Astrophysical Jets

NASA Technical Reports Server (NTRS)

Mayo, Robert M.

1997-01-01

The significance of the work described herein lies in the demonstration of Magnetized Coaxial Plasma Gun (MCG) devices like CPS-1 to produce energetic laboratory magneto-flows with embedded magnetic fields that can be used as a simulation tool to study flow interaction dynamic of jet flows, to demonstrate the magnetic acceleration and collimation of flows with primarily toroidal fields, and study cross field transport in turbulent accreting flows. Since plasma produced in MCG devices have magnetic topology and MHD flow regime similarity to stellar and extragalactic jets, we expect that careful investigation of these flows in the laboratory will reveal fundamental physical mechanisms influencing astrophysical flows. Discussion in the next section (sec.2) focuses on recent results describing collimation, leading flow surface interaction layers, and turbulent accretion. The primary objectives for a new three year effort would involve the development and deployment of novel electrostatic, magnetic, and visible plasma diagnostic techniques to measure plasma and flow parameters of the CPS-1 device in the flow chamber downstream of the plasma source to study, (1) mass ejection, morphology, and collimation and stability of energetic outflows, (2) the effects of external magnetization on collimation and stability, (3) the interaction of such flows with background neutral gas, the generation of visible emission in such interaction, and effect of neutral clouds on jet flow dynamics, and (4) the cross magnetic field transport of turbulent accreting flows. The applicability of existing laboratory plasma facilities to the study of stellar and extragalactic plasma should be exploited to elucidate underlying physical mechanisms that cannot be ascertained though astrophysical observation, and provide baseline to a wide variety of proposed models, MHD and otherwise. The work proposed herin represents a continued effort on a novel approach in relating laboratory experiments to astrophysical jet observation. There exists overwhelming similarity among these flows that has already produced some fascinating results and is expected to continue a high pay off in future flow similarity studies.

Ionization based multi-directional flow sensor

DOEpatents

Chorpening, Benjamin T [Morgantown, WV; Casleton, Kent H [Morgantown, WV

2009-04-28

A method, system, and apparatus for conducting real-time monitoring of flow (airflow for example) in a system (a hybrid power generation system for example) is disclosed. The method, system and apparatus measure at least flow direction and velocity with minimal pressure drop and fast response. The apparatus comprises an ion source and a multi-directional collection device proximate the ion source. The ion source is configured to generate charged species (electrons and ions for example). The multi-directional collection source is configured to determine the direction and velocity of the flow in real-time.

[Comparison and Discussion of National/Military Standards Related to Flow Measurement of Medical Injection Pump].

PubMed

Zhang, Nan; Zhou, Juan; Yu, Jinlai; Hua, Ziyu; Li, Yongxue; Wu, Jiangang

2018-05-30

Medical injection pump is a commonly used clinical equipment with high risk. Accurate detection of flow is an important aspect to ensure its reliable operation. In this paper, we carefully studied and analyzed the flow detection methods of three standards being used in medical injection pump detection in our country. The three standards were compared from the aspects of standard device, flow test point selection, length of test time and accuracy judgment. The advantages and disadvantages of these standards were analyzed and suggestions for improvement were put forward.

Integrated LTCC pressure/flow/temperature multisensor for compressed air diagnostics.

PubMed

Fournier, Yannick; Maeder, Thomas; Boutinard-Rouelle, Grégoire; Barras, Aurélie; Craquelin, Nicolas; Ryser, Peter

2010-01-01

We present a multisensor designed for industrial compressed air diagnostics and combining the measurement of pressure, flow, and temperature, integrated with the corresponding signal conditioning electronics in a single low-temperature co-fired ceramic (LTCC) package. The developed sensor may be soldered onto an integrated electro-fluidic platform by using standard surface mount device (SMD) technology, e.g., as a standard electronic component would be on a printed circuit board, obviating the need for both wires and tubes and thus paving the road towards low-cost integrated electro-fluidic systems. Several performance aspects of this device are presented and discussed, together with electronics design issues.

Integrated LTCC Pressure/Flow/Temperature Multisensor for Compressed Air Diagnostics†

PubMed Central

Fournier, Yannick; Maeder, Thomas; Boutinard-Rouelle, Grégoire; Barras, Aurélie; Craquelin, Nicolas; Ryser, Peter

2010-01-01

We present a multisensor designed for industrial compressed air diagnostics and combining the measurement of pressure, flow, and temperature, integrated with the corresponding signal conditioning electronics in a single low-temperature co-fired ceramic (LTCC) package. The developed sensor may be soldered onto an integrated electro-fluidic platform by using standard surface mount device (SMD) technology, e.g., as a standard electronic component would be on a printed circuit board, obviating the need for both wires and tubes and thus paving the road towards low-cost integrated electro-fluidic systems. Several performance aspects of this device are presented and discussed, together with electronics design issues. PMID:22163518

In-airway molecular flow sensing: A new technology for continuous, noninvasive monitoring of oxygen consumption in critical care.

PubMed

Ciaffoni, Luca; O'Neill, David P; Couper, John H; Ritchie, Grant A D; Hancock, Gus; Robbins, Peter A

2016-08-01

There are no satisfactory methods for monitoring oxygen consumption in critical care. To address this, we adapted laser absorption spectroscopy to provide measurements of O2, CO2, and water vapor within the airway every 10 ms. The analyzer is integrated within a novel respiratory flow meter that is an order of magnitude more precise than other flow meters. Such precision, coupled with the accurate alignment of gas concentrations with respiratory flow, makes possible the determination of O2 consumption by direct integration over time of the product of O2 concentration and flow. The precision is illustrated by integrating the balance gas (N2 plus Ar) flow and showing that this exchange was near zero. Measured O2 consumption changed by <5% between air and O2 breathing. Clinical capability was illustrated by recording O2 consumption during an aortic aneurysm repair. This device now makes easy, accurate, and noninvasive measurement of O2 consumption for intubated patients in critical care possible.

In-airway molecular flow sensing: A new technology for continuous, noninvasive monitoring of oxygen consumption in critical care

PubMed Central

Ciaffoni, Luca; O’Neill, David P.; Couper, John H.; Ritchie, Grant A. D.; Hancock, Gus; Robbins, Peter A.

2016-01-01

There are no satisfactory methods for monitoring oxygen consumption in critical care. To address this, we adapted laser absorption spectroscopy to provide measurements of O2, CO2, and water vapor within the airway every 10 ms. The analyzer is integrated within a novel respiratory flow meter that is an order of magnitude more precise than other flow meters. Such precision, coupled with the accurate alignment of gas concentrations with respiratory flow, makes possible the determination of O2 consumption by direct integration over time of the product of O2 concentration and flow. The precision is illustrated by integrating the balance gas (N2 plus Ar) flow and showing that this exchange was near zero. Measured O2 consumption changed by <5% between air and O2 breathing. Clinical capability was illustrated by recording O2 consumption during an aortic aneurysm repair. This device now makes easy, accurate, and noninvasive measurement of O2 consumption for intubated patients in critical care possible. PMID:27532048

Application of full field optical studies for pulsatile flow in a carotid artery phantom

PubMed Central

Nemati, M.; Loozen, G. B.; van der Wekken, N.; van de Belt, G.; Urbach, H. P.; Bhattacharya, N.; Kenjeres, S.

2015-01-01

A preliminary comparative measurement between particle imaging velocimetry (PIV) and laser speckle contrast analysis (LASCA) to study pulsatile flow using ventricular assist device in a patient-specific carotid artery phantom is reported. These full-field optical techniques have both been used to study flow and extract complementary parameters. We use the high spatial resolution of PIV to generate a full velocity map of the flow field and the high temporal resolution of LASCA to extract the detailed frequency spectrum of the fluid pulses. Using this combination of techniques a complete study of complex pulsatile flow in an intricate flow network can be studied. PMID:26504652

An experimental device for characterizing degassing processes and related elastic fingerprints: Analog volcano seismo-acoustic observations.

PubMed

Spina, Laura; Morgavi, Daniele; Cannata, Andrea; Campeggi, Carlo; Perugini, Diego

2018-05-01

A challenging objective of modern volcanology is to quantitatively characterize eruptive/degassing regimes from geophysical signals (in particular seismic and infrasonic), for both research and monitoring purposes. However, the outcomes of the attempts made so far are still considered very uncertain because volcanoes remain inaccessible when deriving quantitative information on crucial parameters such as plumbing system geometry and magma viscosity. In order to improve our knowledge of volcanic systems, a novel experimental device, which is capable of mimicking volcanic degassing processes with different regimes and gas flow rates, and allowing for the investigation of the related seismo-acoustic emissions, was designed and developed. The benefits of integrating observations on real volcanoes with seismo-acoustic signals generated in laboratory are many and include (i) the possibility to fix the controlling parameters such as the geometry of the structure where the gas flows, the gas flow rate, and the fluid viscosity; (ii) the possibility of performing acoustic measurements at different azimuthal and zenithal angles around the opening of the analog conduit, hence constraining the radiation pattern of different acoustic sources; (iii) the possibility to measure micro-seismic signals in distinct points of the analog conduit; (iv) finally, thanks to the transparent structure, it is possible to directly observe the degassing pattern through the optically clear analog magma and define the degassing regime producing the seismo-acoustic radiations. The above-described device represents a step forward in the analog volcano seismo-acoustic measurements.

An experimental device for characterizing degassing processes and related elastic fingerprints: Analog volcano seismo-acoustic observations

NASA Astrophysics Data System (ADS)

Spina, Laura; Morgavi, Daniele; Cannata, Andrea; Campeggi, Carlo; Perugini, Diego

2018-05-01

A challenging objective of modern volcanology is to quantitatively characterize eruptive/degassing regimes from geophysical signals (in particular seismic and infrasonic), for both research and monitoring purposes. However, the outcomes of the attempts made so far are still considered very uncertain because volcanoes remain inaccessible when deriving quantitative information on crucial parameters such as plumbing system geometry and magma viscosity. In order to improve our knowledge of volcanic systems, a novel experimental device, which is capable of mimicking volcanic degassing processes with different regimes and gas flow rates, and allowing for the investigation of the related seismo-acoustic emissions, was designed and developed. The benefits of integrating observations on real volcanoes with seismo-acoustic signals generated in laboratory are many and include (i) the possibility to fix the controlling parameters such as the geometry of the structure where the gas flows, the gas flow rate, and the fluid viscosity; (ii) the possibility of performing acoustic measurements at different azimuthal and zenithal angles around the opening of the analog conduit, hence constraining the radiation pattern of different acoustic sources; (iii) the possibility to measure micro-seismic signals in distinct points of the analog conduit; (iv) finally, thanks to the transparent structure, it is possible to directly observe the degassing pattern through the optically clear analog magma and define the degassing regime producing the seismo-acoustic radiations. The above-described device represents a step forward in the analog volcano seismo-acoustic measurements.

Compact dual-mode diffuse optical system for blood perfusion monitoring in a porcine model of microvascular tissue flaps

NASA Astrophysics Data System (ADS)

Lee, Seung Yup; Pakela, Julia M.; Helton, Michael C.; Vishwanath, Karthik; Chung, Yooree G.; Kolodziejski, Noah J.; Stapels, Christopher J.; McAdams, Daniel R.; Fernandez, Daniel E.; Christian, James F.; O'Reilly, Jameson; Farkas, Dana; Ward, Brent B.; Feinberg, Stephen E.; Mycek, Mary-Ann

2017-12-01

In reconstructive surgery, the ability to detect blood flow interruptions to grafted tissue represents a critical step in preventing postsurgical complications. We have developed and pilot tested a compact, fiber-based device that combines two complimentary modalities-diffuse correlation spectroscopy (DCS) and diffuse reflectance spectroscopy-to quantitatively monitor blood perfusion. We present a proof-of-concept study on an in vivo porcine model (n=8). With a controllable arterial blood flow supply, occlusion studies (n=4) were performed on surgically isolated free flaps while the device simultaneously monitored blood flow through the supplying artery as well as flap perfusion from three orientations: the distal side of the flap and two transdermal channels. Further studies featuring long-term monitoring, arterial failure simulations, and venous failure simulations were performed on flaps that had undergone an anastomosis procedure (n=4). Additionally, benchtop verification of the DCS system was performed on liquid flow phantoms. Data revealed relationships between diffuse optical measures and state of occlusion as well as the ability to detect arterial and venous compromise. The compact construction of the device, along with its noninvasive and quantitative nature, would make this technology suitable for clinical translation.

[Simulation of rainfall and snowmelt runoff reduction in a northern city based on combination of green ecological strategies.

PubMed

Han, Jin Feng; Liu, Shuo; Dai, Jun; Qiu, Hao

2018-02-01

With the aim to control and reduce rainfall and snowmelt runoff in northern cities in China, the summer runoff and spring snowmelt runoff in the studied area were simulated with the establishment of storm water management model (SWMM). According to the climate characteristics and the situation of the studied area, the low impact development (LID) green ecological strategies suitable for the studied area were established. There were three kinds of management strategies being used, including extended green roof, snow and rainwater harvesting devices, and grass-swales or trenches. We examined the impacts of those integrated green ecological measures on the summer rainfall and spring snowmelt runoff and their mitigation effects on the drainage network pressure. The results showed that the maximum flow rates of the measured rainfall in May 24th, June 10th and July 18th 2016 were 2.7, 6.2 and 7.4 m 3 ·s -1 respectively. The peak flow rates at different return periods of 1, 2, 5, 10 years were 2.39, 3.91, 6.24 and 7.85 m 3 ·s -1 , respectively. In the snowmelt period, the peak flow appeared at the beginning of March. The LID measures had positive effect on peak flow reduction, and thus delayed peak time and relieved drainage pressure. The flow reduction rate was as high as 70%. Moreover, the snow harvesting devices played a positive role in controlling snowmelt runoff in spring.

Obstacles delaying the prompt deployment of piston-type mechanical cardiopulmonary resuscitation devices during emergency department resuscitation: a video-recording and time-motion study.

PubMed

Huang, Edward Pei-Chuan; Wang, Hui-Chih; Ko, Patrick Chow-In; Chang, Anna Marie; Fu, Chia-Ming; Chen, Jiun-Wei; Liao, Yen-Chen; Liu, Hung-Chieh; Fang, Yao-De; Yang, Chih-Wei; Chiang, Wen-Chu; Ma, Matthew Huei-Ming; Chen, Shyr-Chyr

2013-09-01

The quality of cardiopulmonary resuscitation (CPR) is important to survival after cardiac arrest. Mechanical devices (MD) provide constant CPR, but their effectiveness may be affected by deployment timeliness. To identify the timeliness of the overall and of each essential step in the deployment of a piston-type MD during emergency department (ED) resuscitation, and to identify factors associated with delayed MD deployment by video recordings. Between December 2005 and December 2008, video clips from resuscitations with CPR sessions using a MD in the ED were reviewed using time-motion analyses. The overall deployment timeliness and the time spent on each essential step of deployment were measured. There were 37 CPR recordings that used a MD. Deployment of MD took an average 122.6 ± 57.8s. The 3 most time-consuming steps were: (1) setting the device (57.8 ± 38.3s), (2) positioning the patient (33.4 ± 38.0 s), and (3) positioning the device (14.7 ± 9.5s). Total no flow time was 89.1 ± 41.2s (72.7% of total time) and associated with the 3 most time-consuming steps. There was no difference in the total timeliness, no-flow time, and no-flow ratio between different rescuer numbers, time of day of the resuscitation, or body size of patients. Rescuers spent a significant amount of time on MD deployment, leading to long no-flow times. Lack of familiarity with the device and positioning strategy were associated with poor performance. Additional training in device deployment strategies are required to improve the benefits of mechanical CPR. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Atmospheric pressure flow reactor: Gas phase chemical kinetics under tropospheric conditions without wall effects

NASA Technical Reports Server (NTRS)

Koontz, Steven L. (Inventor); Davis, Dennis D. (Inventor)

1991-01-01

A flow reactor for simulating the interaction in the troposphere is set forth. A first reactant mixed with a carrier gas is delivered from a pump and flows through a duct having louvers therein. The louvers straighten out the flow, reduce turbulence and provide laminar flow discharge from the duct. A second reactant delivered from a source through a pump is input into the flowing stream, the second reactant being diffused through a plurality of small diffusion tubes to avoid disturbing the laminar flow. The commingled first and second reactants in the carrier gas are then directed along an elongated duct where the walls are spaced away from the flow of reactants to avoid wall interference, disturbance or turbulence arising from the walls. A probe connected with a measuring device can be inserted through various sampling ports in the second duct to complete measurements of the first and second reactants and the product of their reaction at selected XYZ locations relative to the flowing system.

Test and evaluation of constant-flow devices for use in SSN AFFF proportioning systems. Interim report, January-May 1986

DOE Office of Scientific and Technical Information (OSTI.GOV)

Williams, F.W.; Back, G.G.; Burns, R.E.

1986-11-04

Constant flow devices, which deliver a constant flow of liquid over a range of upstream and downstream pressures, have been suggested as an alternative to orifice plates for proportioning AFFF in SSN 21 fire-suppression systems. Operational and performance characteristics of two lightweight, inexpensive, commercially available constant-flow devices have significant advantages over orifice plates. Both models tested, however, showed performance degradation when subjected to simulated service conditions. A constant flow device with improved resistance to wear and to AFFF exposure is desirable. Since the constant-flow control devices tested improves proportioning efficiency but do not have optimum characteristics, investigation of improved devicesmore » or methods is recommended.« less

40 CFR 63.1452 - What are my monitoring requirements?

Code of Federal Regulations, 2011 CFR

2011-07-01

... a flow sensor calibration check at least semiannually. (3) If a pressure measurement device is used...) through (v) of this section. (i) Locate the pressure sensor(s) in or as close to a position that provides a representative measurement of the pressure. (ii) Minimize or eliminate pulsating pressure...

Autonomous sensor particle for parameter tracking in large vessels

NASA Astrophysics Data System (ADS)

Thiele, Sebastian; Da Silva, Marco Jose; Hampel, Uwe

2010-08-01

A self-powered and neutrally buoyant sensor particle has been developed for the long-term measurement of spatially distributed process parameters in the chemically harsh environments of large vessels. One intended application is the measurement of flow parameters in stirred fermentation biogas reactors. The prototype sensor particle is a robust and neutrally buoyant capsule, which allows free movement with the flow. It contains measurement devices that log the temperature, absolute pressure (immersion depth) and 3D-acceleration data. A careful calibration including an uncertainty analysis has been performed. Furthermore, autonomous operation of the developed prototype was successfully proven in a flow experiment in a stirred reactor model. It showed that the sensor particle is feasible for future application in fermentation reactors and other industrial processes.

Simulations of initial MHD experiments on the Madison Dynamo Experiment

NASA Astrophysics Data System (ADS)

O'Connell, R.; Forest, C. B.; Goldwin, J. M.; Kendrick, R. D.; Canary, H. W.; Nornberg, M. D.; Jaun, A.

1999-11-01

Initial experiments for a liquid metal MHD device have been modelled using measurements from geometrically similar water experiments. In the low B limit the water flows are the same as sodium flows. Two codes have been written to predict 1) linear stability of the system and 2) the response of the system to an externally applied vertical magnetic field, using measured velocity profiles. Predictions are made for a first set of MHD experiments, including: a) demonstration of the distortion and amplification of externally applied magnetic fields by sheared flows, b) demonstration of the β-effect by measurement of the turbulent conductivity, c) demonstration of a turbulent α effect and d) characterization of magnetic eigenmodes.

Quantification of absolute blood velocity using LDA

NASA Astrophysics Data System (ADS)

Borozdova, M. A.; Fedosov, I. V.; Tuchin, V. V.

2018-04-01

We developed novel schematics of a Laser Doppler anemometer where measuring volume is comparable with the red blood cell (RBC) size and a small period of interference fringes improves device resolution. The technique was used to estimate Doppler frequency shift at flow velocity measurements. It has been shown that technique is applicable for measurements in whole blood.

Instantaneous velocity measurement of AC electroosmotic flows by laser induced fluorescence photobleaching anemometer with high temporal resolution

NASA Astrophysics Data System (ADS)

Zhao, Wei; Yang, Fang; Qiao, Rui; Wang, Guiren; Rui Qiao Collaboration

2015-11-01

Understanding the instantaneous response of flows to applied AC electric fields may help understand some unsolved issues in induced-charge electrokinetics and enhance performance of microfluidic devices. Since currently available velocimeters have difficulty in measuring velocity fluctuations with frequency higher than 1 kHz, most experimental studies so far focus only on the average velocity measurement in AC electrokinetic flows. Here, we present measurements of AC electroosmotic flow (AC-EOF) response time in microchannels by a novel velocimeter with submicrometer spatial resolution and microsecond temporal resolution, i.e. laser-induced fluorescence photobleaching anemometer (LIFPA). Several parameters affecting the AC-EOF response time to the applied electric signal were investigated, i.e. channel length, transverse position and solution conductivity. The experimental results show that the EOF response time under a pulsed electric field decreases with the reduction of the microchannel length, distance between the detection position to the wall and the conductivity of the solution. This work could provide a new powerful tool to measure AC electrokinetics and enhance our understanding of AC electrokinetic flows.

TDLAS-based sensors for in situ measurement of syngas composition in a pressurized, oxygen-blown, entrained flow coal gasifier

NASA Astrophysics Data System (ADS)

Sur, Ritobrata; Sun, Kai; Jeffries, Jay B.; Hanson, Ronald K.; Pummill, Randy J.; Waind, Travis; Wagner, David R.; Whitty, Kevin J.

2014-07-01

Tunable diode laser absorption spectroscopy based in situ sensors for CO (2.33 μm), CO2 (2.02 μm), CH4 (2.29 μm) and H2O (1.35 μm) were deployed in a pilot-scale (1 ton/day), high-pressure (up to 18 atm), entrained flow, oxygen-blown, slagging coal gasifier at the University of Utah. Measurements of species mole fraction with 3-s time resolution were taken at the pre- and post-filtration stages of the gasifier synthesis gas (called here syngas) output flow. Although particulate scattering makes pre-filter measurements more difficult, this location avoids the time delay of flow through the filtration devices. With the measured species and known N2 concentrations, the H2 content was obtained via balance. The lower heating value and the Wobbe index of the gas mixture were estimated using the measured gas composition. The sensors demonstrated here show promise for monitoring and control of the gasification process.

Support with intra-aortic balloon pump vs. Impella2.5® and blood flow to the heart, brain and kidneys - an experimental porcine model of ischaemic heart failure.

PubMed

Møller-Helgestad, Ole K; Poulsen, Christian B; Christiansen, Evald H; Lassen, Jens F; Ravn, Hanne B

2015-01-15

Cardiogenic shock as a complication to an acute myocardial infarction has an unacceptably high death rate that has not changed for the last 15years. Mortality is partly related to organ hypoperfusion and mechanical assist devices are used for the most severe cases but we do not know which assist device is the best option. Therefore, we have investigated how an IABP and an Impella®-pump influenced blood flow to the brain, heart and kidneys, in a closed-chest porcine model of severe left ventricular failure. 13 pigs were anesthetised and left ventricular failure was induced by occluding the proximal LAD for 45min followed by 30min of reperfusion. Blood flow was measured in the carotid artery, the LAD, and the renal artery. The Impella® and IABP were inserted via the femoral arteries, and the two devices were tested individually and combined after induction of heart failure. Carotid- (p=0.01) and renal blood flow (p=0.045) were higher on Impella®-support, compared to no support. None of the devices altered the blood flow in the LAD. Cardiac power output (p<0.005) and left ventricular work (p<0.00) were also higher on Impella®-support compared to no support. Haemodynamics and blood flow to the brain and kidneys were significantly better on Impella®-support, suggesting that the Impella® is superior to the IABP in a state of ischaemia induced left ventricular failure. These data, however, needs to be confirmed in a proper clinical trial with patients in cardiogenic shock. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Final report on the Controlled Cold Helium Spill Test in the LHC tunnel at CERN

NASA Astrophysics Data System (ADS)

Dufay-Chanat, L.; Bremer, J.; Casas-Cubillos, J.; Chorowski, M.; Grabowski, M.; Jedrusyna, A.; Lindell, G.; Nonis, M.; Koettig, T.; Vauthier, N.; van Weelderen, R.; Winkler, T.

2015-12-01

The 27 km circumference LHC underground tunnel is a space in which the helium cooled LHC magnets are installed. The vacuum enclosures of the superconducting magnets are protected by over-pressure safety relief devices that open whenever cold helium escapes either from the magnet cold enclosure or from the helium supply headers, into this vacuum enclosure. A 3-m long no stay zone around these devices is defined based on scale model studies, protecting the personnel against cold burns or asphyxia caused by such a helium release event. Recently, several simulation studies have been carried out modelling the propagation of the helium/air mixture, resulting from the opening of such a safety device, along the tunnel. The released helium flows vary in the range between 1 kg/s and 0.1 kg/s. To validate these different simulation studies, real life mock-up tests have been performed inside the LHC tunnel, releasing helium flow rates of 1 kg/s, 0.3 kg/s and 0.1 kg/s. For each test, up to 1000 liters of liquid helium were released under standard operational tunnel conditions. The data recorded include oxygen concentration, temperature and flow speed measurements, and video footage used to assess qualitatively the visibility. These measurements have been made in the up- and downstream directions, with respect to the air ventilation flow, of the spill point. This paper presents the experimental set-up under which these release tests were made, the effects of these releases on the atmospheric tunnel condition as a function of the release flow rate. We discuss the modification to the personnel access conditions to the LHC tunnel that are presently implemented as a result of these tests.

From hemodynamic towards cardiomechanic sensors in implantable devices

NASA Astrophysics Data System (ADS)

Ferek-Petric, Bozidar

2013-06-01

Sensor could significantly improve the cardiac electrotherapy. It has to provide long-term stabile signal not impeding the device longevity and lead reliability. It may not introduce special implantation and adjustment procedures. Hemodynamic sensors based on the blood flow velocity and cardiomechanic sensors based on the lead bending measurement are disclosed. These sensors have a broad clinical utility. Triboelectric and high-frequency lead bending sensors yield accurate and stable signals whereby functioning with every cardiac lead. Moreover, high frequency measurement avoids use of any kind of special hardware mounted on the cardiac lead.

Landau-Squire jet as a versatile probe to measure flow rate through individual nanochannel and nanotubes

NASA Astrophysics Data System (ADS)

Secchi, Eleonora; Marbach, Sophie; Siria, Alessandro; Bocquet, Lyderic

2015-11-01

Over the last decade, nanometric sized channels have been intensively investigated since new model of fluid transport are expected due to the flow confinement at the nanometric scale. Nanoconfinement generates new phenomena, such as superfast flows in carbon nanotubes and slippage over smooth surfaces. However, a major challenge of nanofluidics lies in fabricating nanoscale fluidic devices and developing new velocimetry techniques able to measure flow rates down to femtoL/s. In this work we report the experimental study of the velocity fields generated by pressure driven flow from glass nanochannel with a diameter ranging from 1 μm to 100nm. The flow emerging from these channels can be described by the classical Landau-Squire solution of the Navier-Stokes equation for a point jet. We show that due to the peculiarity of this flow, it can be used as an efficient probe to characterize the permeability of nanochannels. Velocity field is measured experimentally seeding the fluid in the reservoir with 500 nm Polystyrene particles and measuring the velocity with a standard PIV algorithm. Predictions are tested for nanochannels of several dimensions and supported by ionic current measurement. This demonstrates that this technique is a powerful tool to characterize the flow through nanochannels. We finally apply this method to the measurement of the flow emerging from a single carbon nanotube inserted in the nanochannels and present first data of permeability measurement through a single nanotube.

An implantable blood pressure and flow transmitter.

NASA Technical Reports Server (NTRS)

Rader, R. D.; Meehan, J. P.; Henriksen, J. K. C.

1973-01-01

A miniature totally implantable FM/FM telemetry system has been developed to simultaneously measure blood pressure and blood flow, thus providing an appreciation of the hemodynamics of the circulation to the entire body or to a particular organ. Developed for work with animal subjects, the telemetry system's transmission time is controlled by an RF signal that permits an operating life of several months. Pressure is detected by a miniature intravascular transducer and flow is detected by an extravascular interferometric ultrasonic technique. Both pressure and flow are calibrated prior to implanting. The pressure calibration can be checked after the implanting by cannulation; flow calibration can be verified only at the end of the experiment by determining the voltage output from the implanted sensing system as a function of several measured flow rates. The utility of this device has been established by its use in investigating canine renal circulation during exercise, emotional encounters, administration of drugs, and application of accelerative forces.

Design and evaluation of a miniature laser speckle imaging device to assess gingival health

PubMed Central

Regan, Caitlin; White, Sean M.; Yang, Bruce Y.; Takesh, Thair; Ho, Jessica; Wink, Cherie; Wilder-Smith, Petra; Choi, Bernard

2016-01-01

Abstract. Current methods used to assess gingivitis are qualitative and subjective. We hypothesized that gingival perfusion measurements could provide a quantitative metric of disease severity. We constructed a compact laser speckle imaging (LSI) system that could be mounted in custom-made oral molds. Rigid fixation of the LSI system in the oral cavity enabled measurement of blood flow in the gingiva. In vitro validation performed in controlled flow phantoms demonstrated that the compact LSI system had comparable accuracy and linearity compared to a conventional bench-top LSI setup. In vivo validation demonstrated that the compact LSI system was capable of measuring expected blood flow dynamics during a standard postocclusive reactive hyperemia and that the compact LSI system could be used to measure gingival blood flow repeatedly without significant variation in measured blood flow values (p<0.05). Finally, compact LSI system measurements were collected from the interdental papilla of nine subjects and compared to a clinical assessment of gingival bleeding on probing. A statistically significant correlation (ρ=0.53; p<0.005) was found between these variables, indicating that quantitative gingival perfusion measurements performed using our system may aid in the diagnosis and prognosis of periodontal disease. PMID:27787545

Design and evaluation of a miniature laser speckle imaging device to assess gingival health

NASA Astrophysics Data System (ADS)

Regan, Caitlin; White, Sean M.; Yang, Bruce Y.; Takesh, Thair; Ho, Jessica; Wink, Cherie; Wilder-Smith, Petra; Choi, Bernard

2016-10-01

Current methods used to assess gingivitis are qualitative and subjective. We hypothesized that gingival perfusion measurements could provide a quantitative metric of disease severity. We constructed a compact laser speckle imaging (LSI) system that could be mounted in custom-made oral molds. Rigid fixation of the LSI system in the oral cavity enabled measurement of blood flow in the gingiva. In vitro validation performed in controlled flow phantoms demonstrated that the compact LSI system had comparable accuracy and linearity compared to a conventional bench-top LSI setup. In vivo validation demonstrated that the compact LSI system was capable of measuring expected blood flow dynamics during a standard postocclusive reactive hyperemia and that the compact LSI system could be used to measure gingival blood flow repeatedly without significant variation in measured blood flow values (p<0.05). Finally, compact LSI system measurements were collected from the interdental papilla of nine subjects and compared to a clinical assessment of gingival bleeding on probing. A statistically significant correlation (ρ=0.53 p<0.005) was found between these variables, indicating that quantitative gingival perfusion measurements performed using our system may aid in the diagnosis and prognosis of periodontal disease.

Experimental flow studies in glaucoma drainage device development.

PubMed

2001-10-01

(I) To examine whether small holes produced by 248 nm excimer laser ablation in a polymer substrate could consistently produce a pressure drop in the desired target range (5-15 mm Hg) at physiological aqueous flow rates for use as an internal flow restrictor in a glaucoma drainage device, and (ii) to investigate whether external leakage could be reduced in comparison with conventional tube and plate glaucoma drainage devices by redesigning the exterior cross sectional shape of the portion contained within the sclerocorneal tunnel. Single holes with target diameters of 10 microm, 15 microm, 20 microm, and 25 microm were drilled using a 248 nm excimer laser in sample discs (n=6 at each diameter) punched from a 75 microm thick polyimide sheet. Sample discs were tested in a flow rig designed to measure the pressure drop across the discs. Using filtered, degassed water at a flow rate of 1.4 microl/min repeated flow measurements were taken (n=6) for each disc. After flow testing, all discs were imaged using a scanning electron microscope and the dimensions of each hole were derived using image analysis software. In the external leakage study, corneoscleral buttons (n=13) were prepared from cadaver pig eyes and mounted on an artificial anterior chamber infused with Tyrode solution. After the pressure had stabilised, standard occluded silicone tube implants were inserted through 23 gauge needle stab incisions at the limbus. These were compared against prototype PMMA implants with a novel shape profile inserted through 1.15 mm width microvitreoretinal (MVR) stab incisions at the limbus. The infusion rate was maintained and a second pressure measurement was taken when the pressure had stabilised. The difference between the first and second pressure measurement was then compared, as an index of external leakage. Ablated tubes were found to have a near perfect circular outline on both the entry and exit side. The observed pressure drops across the ablated sample discs at each target diameter were as follows: 10 microm, mean 25.66 (SD 4.9) mm Hg; 15 microm, 6.7 (1.15); 20 microm, 1.66 (1.07); and 25 microm, <0.1 mm Hg. A strong correlation was observed between observed pressure drops and those predicted by Poiseuille's formula (R(2) =0.996). Target ablations of 15 microm diameter produced tubes that consistently achieved a pressure drop within the desired range (5-15 mm Hg). In the external leakage study, preinsertion pressures (mm Hg; mean (SD)) were 19.00 (4.3) (conventional method) and 20.00 (3.9) (new technique with PMMA prototypes). Post-insertion pressures were significantly reduced (10.40 (7.7); p<0.01) for the conventional technique and were essentially unchanged for the new technique (18.80 (4.9); p>0.1). It was shown that it is possible, in principle, to control the dimensions of a manufactured tubular lumen in a glaucoma drainage device accurately enough to provide consistent protection from hypotony in the early period after glaucoma filtration surgery. By redesigning the external profile of glaucoma drainage device and incision technique, it was also shown that it is possible to eliminate uncontrolled external leakage.

Microfluidic flows of wormlike micellar solutions.

PubMed

Zhao, Ya; Cheung, Perry; Shen, Amy Q

2014-09-01

The widespread use of wormlike micellar solutions is commonly found in household items such as cosmetic products, industrial fluids used in enhanced oil recovery and as drag reducing agents, and in biological applications such as drug delivery and biosensors. Despite their extensive use, there are still many details about the microscopic micellar structure and the mechanisms by which wormlike micelles form under flow that are not clearly understood. Microfluidic devices provide a versatile platform to study wormlike micellar solutions under various flow conditions and confined geometries. A review of recent investigations using microfluidics to study the flow of wormlike micelles is presented here with an emphasis on three different flow types: shear, elongation, and complex flow fields. In particular, we focus on the use of shear flows to study shear banding, elastic instabilities of wormlike micellar solutions in extensional flow (including stagnation and contraction flow field), and the use of contraction geometries to measure the elongational viscosity of wormlike micellar solutions. Finally, we showcase the use of complex flow fields in microfluidics to generate a stable and nanoporous flow-induced structured phase (FISP) from wormlike micellar solutions. This review shows that the influence of spatial confinement and moderate hydrodynamic forces present in the microfluidic device can give rise to a host of possibilities of microstructural rearrangements and interesting flow phenomena. Copyright © 2014 Elsevier B.V. All rights reserved.

Improving H-Q rating curves in temprorary streams by using Acoustic Doppler Current meters

NASA Astrophysics Data System (ADS)

Marchand, P.; Salles, C.; Rodier, C.; Hernandez, F.; Gayrard, E.; Tournoud, M.-G.

2012-04-01

Intermittent rivers pose different challenges to stream rating due to high spatial and temporal gradients. Long dry periods, cut by short duration flush flood events explain the difficulty to obtain reliable discharge data, for low flows as well as for floods: problems occur with standard gauging, zero flow period, etc. Our study aims to test the use of an acoustic Doppler currentmeter (ADC) for improving stream rating curves in small catchments subject to large variations of discharge, solid transport and high eutrophication levels. The study is conducted at the outlet of the river Vène, a small coastal river (67 km2) located close to the city of Montpellier (France). The low flow period lasts for more than 6 month; during this period the river flow is sustained by effluents from urban sewage systems, which allows development of algae and macrophytes in the riverbed. The ADC device (Sontek ®Argonaut SW) is a pulsed Doppler current profiling system designed for measuring water velocity profiles and levels that are used to compute volumetric flow rates. It is designed for shallow waters (less than 4 meter depth). Its main advantages are its low cost and high accuracy (±1% of the measured velocity or ±0.05 m/sec, as reported by the manufacturer). The study will evaluate the improvement in rating curves in an intermittent flow context and the effect of differences in sensitivity between low and high water level, by comparing mean flow velocity obtained by ADC to direct discharges measurements. The study will also report long-term use of ADC device, by considering effects of biofilms, algae and macrophytes, as well as solid transport on the accuracy of the measurements. In conclusion, we show the possibility to improve stream rating and continuous data collection of an intermittent river by using a ADC with some precautions.

Point-of-care coagulation monitoring: first clinical experience using a paper-based lateral flow diagnostic device.

PubMed

Hegener, Michael A; Li, Hua; Han, Daewoo; Steckl, Andrew J; Pauletti, Giovanni M

2017-09-01

Vitamin K antagonists such as warfarin are the most widely used class of oral anticoagulants. Due to a narrow therapeutic window, patients on warfarin require regular monitoring. Self-testing using point-of-care (POC) diagnostic devices is available, but cost makes this monitoring method beyond reach for many. The main objective of this research was to assess the clinical utility of a low-cost, paper-based lateral flow POC diagnostic device developed for anticoagulation monitoring without the need for a separate electronic reader. Custom-fabricated lateral flow assay (LFA) test strips comprised of a glass fiber sample pad, a nitrocellulose analytical membrane, a cellulose wicking pad, and a plastic backing card were assembled in a plastic cassette. Healthy volunteers and patients on warfarin therapy were recruited for this prospective study. For each participant, a whole blood sample was collected via fingerstick to determine: (1) international normalized ratio (INR) using the CoaguChek® XS coagulometer, (2) hematocrit by centrifugation, and (3) red blood cell (RBC) travel distance on the experimental LFA device after 240 s using digital image analysis. RBC travel distance measured on the LFA device using blood samples obtained from warfarin patients positively correlated with increasing INR value and the LFA device had the capability to statistically distinguish between healthy volunteer INR values and those for patients groups with INR ≥ 2.6. From these data, it is predicted that this low-cost, paper-based LFA device can have clinical utility for identifying anticoagulated patients taking vitamin K antagonists who are outside of the desired therapeutic efficacy window.

Hydrodynamics-induced variability in the USP apparatus II dissolution test.

PubMed

Baxter, Jennifer L; Kukura, Joseph; Muzzio, Fernando J

2005-03-23

The USP tablet dissolution test is an analytical tool used for the verification of drug release processes and formulation selection within the pharmaceutical industry. Given the strong impact of this test, it is surprising that operating conditions and testing devices have been selected empirically. In fact, the flow phenomena in the USP test have received little attention in the past. An examination of the hydrodynamics in the USP apparatus II shows that the device is highly vulnerable to mixing problems that can affect testing performance and consistency. Experimental and computational techniques reveal that the flow field within the device is not uniform, and dissolution results can vary dramatically with the position of the tablet within the vessel. Specifically, computations predict sharp variations in the shear along the bottom of the vessel where the tablet is most likely to settle. Experiments in which the tablet location was carefully controlled reveal that the variation of shear within the testing device can affect the measured dissolution rate.

Acoustic transducer in system for gas temperature measurement in gas turbine engine

DOE Office of Scientific and Technical Information (OSTI.GOV)

DeSilva, Upul P.; Claussen, Heiko

An apparatus for controlling operation of a gas turbine engine including at least one acoustic transmitter/receiver device located on a flow path boundary structure. The acoustic transmitter/receiver device includes an elongated sound passage defined by a surface of revolution having opposing first and second ends and a central axis extending between the first and second ends, an acoustic sound source located at the first end, and an acoustic receiver located within the sound passage between the first and second ends. The boundary structure includes an opening extending from outside the boundary structure to the flow path, and the second endmore » of the surface of revolution is affixed to the boundary structure at the opening for passage of acoustic signals between the sound passage and the flow path.« less

Personal cooling air filtering device

DOEpatents

Klett, James [Knoxville, TN; Conway, Bret [Denver, NC

2002-08-13

A temperature modification system for modifying the temperature of fluids includes at least one thermally conductive carbon foam element, the carbon foam element having at least one flow channel for the passage of fluids. At least one temperature modification device is provided, the temperature modification device thermally connected to the carbon foam element and adapted to modify the temperature of the carbon foam to modify the temperature of fluids flowing through the flow channels. Thermoelectric and/or thermoionic elements can preferably be used as the temperature modification device. A method for the reversible temperature modification of fluids includes the steps of providing a temperature modification system including at least one thermally conductive carbon foam element having flow channels and at least one temperature modification device, and flowing a fluid through the flow channels.

Simultaneous moisture content and mass flow measurements in wood chip flows using coupled dielectric and impact sensors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pan, Pengmin; McDonald, Timothy; Fulton, John

An 8-electrode capacitance tomography (ECT) sensor was built and used to measure moisture content (MC) and mass flow of pine chip flows. The device was capable of directly measuring total water quantity in a sample but was sensitive to both dry matter and moisture, and therefore required a second measurement of mass flow to calculate MC. Two means of calculating the mass flow were used: the first being an impact sensor to measure total mass flow, and the second a volumetric approach based on measuring total area occupied by wood in images generated using the capacitance sensor’s tomographic mode. Testsmore » were made on 109 groups of wood chips ranging in moisture content from 14% to 120% (dry basis) and wet weight of 280 to 1100 g. Sixty groups were randomly selected as a calibration set, and the remaining were used for validation of the sensor’s performance. For the combined capacitance/force transducer system, root mean square errors of prediction (RMSEP) for wet mass flow and moisture content were 13.42% and 16.61%, respectively. RMSEP using the combined volumetric mass flow/capacitance sensor for dry mass flow and moisture content were 22.89% and 24.16%, respectively. Either of the approaches was concluded to be feasible for prediction of moisture content in pine chip flows, but combining the impact and capacitance sensors was easier to implement. As a result, in situations where flows could not be impeded, however, the tomographic approach would likely be more useful.« less

Simultaneous moisture content and mass flow measurements in wood chip flows using coupled dielectric and impact sensors

DOE PAGES

Pan, Pengmin; McDonald, Timothy; Fulton, John; ...

2016-12-23

An 8-electrode capacitance tomography (ECT) sensor was built and used to measure moisture content (MC) and mass flow of pine chip flows. The device was capable of directly measuring total water quantity in a sample but was sensitive to both dry matter and moisture, and therefore required a second measurement of mass flow to calculate MC. Two means of calculating the mass flow were used: the first being an impact sensor to measure total mass flow, and the second a volumetric approach based on measuring total area occupied by wood in images generated using the capacitance sensor’s tomographic mode. Testsmore » were made on 109 groups of wood chips ranging in moisture content from 14% to 120% (dry basis) and wet weight of 280 to 1100 g. Sixty groups were randomly selected as a calibration set, and the remaining were used for validation of the sensor’s performance. For the combined capacitance/force transducer system, root mean square errors of prediction (RMSEP) for wet mass flow and moisture content were 13.42% and 16.61%, respectively. RMSEP using the combined volumetric mass flow/capacitance sensor for dry mass flow and moisture content were 22.89% and 24.16%, respectively. Either of the approaches was concluded to be feasible for prediction of moisture content in pine chip flows, but combining the impact and capacitance sensors was easier to implement. As a result, in situations where flows could not be impeded, however, the tomographic approach would likely be more useful.« less

Simultaneous Moisture Content and Mass Flow Measurements in Wood Chip Flows Using Coupled Dielectric and Impact Sensors

PubMed Central

Pan, Pengmin; McDonald, Timothy; Fulton, John; Via, Brian; Hung, John

2016-01-01

An 8-electrode capacitance tomography (ECT) sensor was built and used to measure moisture content (MC) and mass flow of pine chip flows. The device was capable of directly measuring total water quantity in a sample but was sensitive to both dry matter and moisture, and therefore required a second measurement of mass flow to calculate MC. Two means of calculating the mass flow were used: the first being an impact sensor to measure total mass flow, and the second a volumetric approach based on measuring total area occupied by wood in images generated using the capacitance sensor’s tomographic mode. Tests were made on 109 groups of wood chips ranging in moisture content from 14% to 120% (dry basis) and wet weight of 280 to 1100 g. Sixty groups were randomly selected as a calibration set, and the remaining were used for validation of the sensor’s performance. For the combined capacitance/force transducer system, root mean square errors of prediction (RMSEP) for wet mass flow and moisture content were 13.42% and 16.61%, respectively. RMSEP using the combined volumetric mass flow/capacitance sensor for dry mass flow and moisture content were 22.89% and 24.16%, respectively. Either of the approaches was concluded to be feasible for prediction of moisture content in pine chip flows, but combining the impact and capacitance sensors was easier to implement. In situations where flows could not be impeded, however, the tomographic approach would likely be more useful. PMID:28025536

Surface-acoustic-wave (SAW) flow sensor

NASA Astrophysics Data System (ADS)

Joshi, Shrinivas G.

1991-03-01

The use of a surface-acoustic-wave (SAW) device to measure the rate of gas flow is described. A SAW oscillator heated to a suitable temperature above ambient is placed in the path of a flowing gas. Convective cooling caused by the gas flow results in a change in the oscillator frequency. A 73-MHz oscillator fabricated on 128 deg rotated Y-cut lithium niobate substrate and heated to 55 C above ambient shows a frequency variation greater than 142 kHz for flow-rate variation from 0 to 1000 cu cm/min. The output of the sensor can be calibrated to provide a measurement of volume flow rate, pressure differential across channel ports, or mass flow rate. High sensitivity, wide dynamic range, and direct digital output are among the attractive features of this sensor. Theoretical expressions for the sensitivity and response time of the sensor are derived. It is shown that by using ultrasonic Lamb waves propagating in thin membranes, a flow sensor with faster response than a SAW sensor can be realized.

Surface-acoustic-wave (SAW) flow sensor.

PubMed

Joshi, S G

1991-01-01

The use of a surface-acoustic-wave (SAW) device to measure the rate of gas flow is described. A SAW oscillator heated to a suitable temperature above ambient is placed in the path of a flowing gas. Convective cooling caused by the gas flow results in a change in the oscillator frequency. A 73-MHz oscillator fabricated on 128 degrees rotated Y-cut lithium niobate substrate and heated to 55 degrees C above ambient shows a frequency variation greater than 142 kHz for flow-rate variation from 0 to 1000 cm(3)/min. The output of the sensor can be calibrated to provide a measurement of volume flow rate, pressure differential across channel ports, or mass flow rate. High sensitivity, wide dynamic range, and direct digital output are among the attractive features of this sensor. Theoretical expressions for the sensitivity and response time of the sensor are derived. It is shown that by using ultrasonic Lamb waves, propagating in thin membranes, a flow sensor with faster response than a SAW sensor can be realized.

A New Differential Pressure Flow Meter for Measurement of Human Breath Flow: Simulation and Experimental Investigation

PubMed Central

Bridgeman, Devon; Tsow, Francis; Xian, Xiaojun; Forzani, Erica

2016-01-01

The development and performance characterization of a new differential pressure-based flow meter for human breath measurements is presented in this article. The device, called a “Confined Pitot Tube,” is comprised of a pipe with an elliptically shaped expansion cavity located in the pipe center, and an elliptical disk inside the expansion cavity. The elliptical disk, named Pitot Tube, is exchangeable, and has different diameters, which are smaller than the diameter of the elliptical cavity. The gap between the disk and the cavity allows the flow of human breath to pass through. The disk causes an obstruction in the flow inside the pipe, but the elliptical cavity provides an expansion for the flow to circulate around the disk, decreasing the overall flow resistance. We characterize the new sensor flow experimentally and theoretically, using Comsol Multiphysics® software with laminar and turbulent models. We also validate the sensor, using inhalation and exhalation tests and a reference method. PMID:27818521

Modifications to the nozzle test chamber to extend nozzle static-test capability

NASA Technical Reports Server (NTRS)

Keyes, J. W.

1985-01-01

The nozzle test chamber was modified to provide a high-pressure-ratio nozzle static-test capability. Experiments were conducted to determine the range of the ratio of nozzle total pressure to chamber pressure and to make direct nozzle thrust measurements using a three-component strain-gage force balance. Pressure ratios from 3 to 285 were measured with several axisymmetric nozzles at a nozzle total pressure of 15 to 190 psia. Devices for measuring system mass flow were calibrated using standard axisymmetric convergent choked nozzles. System mass-flow rates up to 10 lbm/sec are measured. The measured thrust results of these nozzles are in good agreement with one-dimensional theoretical predictions for convergent nozzles.

In vitro experiments of cerebral blood flow during aspiration thrombectomy: potential effects on cerebral perfusion pressure and collateral flow.

PubMed

Lally, Frank; Soorani, Mitra; Woo, Timothy; Nayak, Sanjeev; Jadun, Changez; Yang, Ying; McCrudden, John; Naire, Shailesh; Grunwald, Iris; Roffe, Christine

2016-09-01

Mechanical thrombectomy with stent retriever devices is associated with significantly better outcomes than thrombolysis alone in the treatment of acute ischemic stroke. Thrombus aspiration achieves high patency rates, but clinical outcomes are variable. The aim of this study was to examine the effect of different suction conditions on perfusate flow during aspiration thrombectomy. A computational fluid dynamics model of an aspiration device within a patent and occluded blood vessel was used to simulate flow characteristics using fluid flow solver software. A physical particulate flow model of a patent vessel and a vessel occluded by thrombus was then used to visualize flow direction and measure flow rates with the aspiration catheter placed 1-10 mm proximal of the thrombus, and recorded on video. The mathematical model predicted that, in a patent vessel, perfusate is drawn from upstream of the catheter tip while, in an occluded system, perfusate is drawn from the vessel proximal to the device tip with no traction on the occlusion distal of the tip. The in vitro experiments confirmed the predictions of this model. In the occluded vessel aspiration had no effect on the thrombus unless the tip of the catheter was in direct contact with the thrombus. These experiments suggest that aspiration is only effective if the catheter tip is in direct contact with the thrombus. If the catheter tip is not in contact with the thrombus, aspirate is drawn from the vessels proximal of the occlusion. This could affect collateral flow in vivo. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

In-situ temperature-controllable shear flow device for neutron scattering measurement--an example of aligned bicellar mixtures.

PubMed

Xia, Yan; Li, Ming; Kučerka, Norbert; Li, Shutao; Nieh, Mu-Ping

2015-02-01

We have designed and constructed a temperature-controllable shear flow cell for in-situ study on flow alignable systems. The device has been tested in the neutron diffraction and has the potential to be applied in the small angle neutron scattering configuration to characterize the nanostructures of the materials under flow. The required sample amount is as small as 1 ml. The shear rate on the sample is controlled by the flow rate produced by an external pump and can potentially vary from 0.11 to 3.8 × 10(5) s(-1). Both unidirectional and oscillational flows are achievable by the setting of the pump. The instrument is validated by using a lipid bicellar mixture, which yields non-alignable nanodisc-like bicelles at low T and shear-alignable membranes at high T. Using the shear cell, the bicellar membranes can be aligned at 31 °C under the flow with a shear rate of 11.11 s(-1). Multiple high-order Bragg peaks are observed and the full width at half maximum of the "rocking curve" around the Bragg's condition is found to be 3.5°-4.1°. It is noteworthy that a portion of the membranes remains aligned even after the flow stops. Detailed and comprehensive intensity correction for the rocking curve has been derived based on the finite rectangular sample geometry and the absorption of the neutrons as a function of sample angle [See supplementary material at http://dx.doi.org/10.1063/1.4908165 for the detailed derivation of the absorption correction]. The device offers a new capability to study the conformational or orientational anisotropy of the solvated macromolecules or aggregates induced by the hydrodynamic interaction in a flow field.

Viscous electron flow in mesoscopic two-dimensional electron gas

NASA Astrophysics Data System (ADS)

Gusev, G. M.; Levin, A. D.; Levinson, E. V.; Bakarov, A. K.

2018-02-01

We report electrical and magneto transport measurements in mesoscopic size, two-dimensional (2D) electron gas in a GaAs quantum well. Remarkably, we find that the probe configuration and sample geometry strongly affects the temperature evolution of local resistance. We attribute all transport properties to the presence of hydrodynamic effects. Experimental results confirm the theoretically predicted significance of viscous flow in mesoscopic devices.

Fluorescence particle detection using microfluidics and planar optoelectronic elements

NASA Astrophysics Data System (ADS)

Kettlitz, Siegfried W.; Moosmann, Carola; Valouch, Sebastian; Lemmer, Uli

2014-05-01

Detection of fluorescent particles is an integral part of flow cytometry for analysis of selectively stained cells. Established flow cytometer designs achieve great sensitivity and throughput but require bulky and expensive components which prohibit mass production of small single-use point-of-care devices. The use of a combination of innovative technologies such as roll-to-roll printed microuidics with integrated optoelectronic components such as printed organic light emitting diodes and printed organic photodiodes enables tremendous opportunities in cost reduction, miniaturization and new application areas. In order to harvest these benefits, the optical setup requires a redesign to eliminate the need for lenses, dichroic mirrors and lasers. We investigate the influence of geometric parameters on the performance of a thin planar design which uses a high power LED as planar light source and a PIN-photodiode as planar detector. Due to the lack of focusing optics and inferior optical filters, the device sensitivity is not yet on par with commercial state of the art flow cytometer setups. From noise measurements, electronic and optical considerations we deduce possible pathways of improving the device performance. We identify that the sensitivity is either limited by dark noise for very short apertures or by noise from background light for long apertures. We calculate the corresponding crossover length. For the device design we conclude that a low device thickness, low particle velocity and short aperture length are necessary to obtain optimal sensitivity.

A Stabilization Device That Promotes the Efficiency of Cardiopulmonary Resuscitation during Ambulance Transportation to the Level as under Non-Moving Conditions

PubMed Central

Foo, Ning-Ping; Chang, Jer-Hao; Su, Shih-Bin; Chen, Kow-Tong; Cheng, Ching-Fa; Chen, Pei-Chung

2014-01-01

Background The survival rate of patients with out-of-hospital cardiac arrest is low, and measures to improve the quality of cardiopulmonary resuscitation (CPR) during ambulance transportation are desirable. We designed a stabilization device, and in a randomized crossover trial we found performing CPR in a moving ambulance with the device (MD) could achieve better efficiency than that without the device (MND), but the efficiency was lower than that in a non-moving ambulance (NM). Purpose To evaluate whether a modified version of the stabilization device, can promote further the quality of CPR during ambulance transportation. Methods Participants of the previous study were recruited, and they performed CPR for 10 minutes in a moving ambulance with the modified version of the stabilization device (MVSD). The primary outcomes were effective chest compressions and no-flow fraction recorded by a skill-reporter manikin. The secondary outcomes included back pain, physiological parameters, and the participants' rating about the device after performing CPR. Results The overall effective compressions in 10 minutes were 86.4±17.5% for NM, 60.9±14.6% for MND, 69.7±22.4% for MD, and 86.6%±13.2% for MVSD (p<0.001). Whereas changes in back pain severity and physiology parameters were similar under all conditions, MVSD had the lowest no-flow fraction. Differences in effective compressions and the no-flow fraction between MVSD and NM did not reach statistical significance. Conclusions The use of the modified device can improve quality of CPR in a moving ambulance to a level similar to that in a non-moving condition without increasing the severity of back pain. PMID:25329643

A stabilization device that promotes the efficiency of cardiopulmonary resuscitation during ambulance transportation to the level as under non-moving conditions.

PubMed

Foo, Ning-Ping; Chang, Jer-Hao; Su, Shih-Bin; Chen, Kow-Tong; Cheng, Ching-Fa; Chen, Pei-Chung; Lin, Tsung-Yi; Guo, How-Ran

2014-01-01

The survival rate of patients with out-of-hospital cardiac arrest is low, and measures to improve the quality of cardiopulmonary resuscitation (CPR) during ambulance transportation are desirable. We designed a stabilization device, and in a randomized crossover trial we found performing CPR in a moving ambulance with the device (MD) could achieve better efficiency than that without the device (MND), but the efficiency was lower than that in a non-moving ambulance (NM). To evaluate whether a modified version of the stabilization device, can promote further the quality of CPR during ambulance transportation. Participants of the previous study were recruited, and they performed CPR for 10 minutes in a moving ambulance with the modified version of the stabilization device (MVSD). The primary outcomes were effective chest compressions and no-flow fraction recorded by a skill-reporter manikin. The secondary outcomes included back pain, physiological parameters, and the participants' rating about the device after performing CPR. The overall effective compressions in 10 minutes were 86.4±17.5% for NM, 60.9±14.6% for MND, 69.7±22.4% for MD, and 86.6%±13.2% for MVSD (p<0.001). Whereas changes in back pain severity and physiology parameters were similar under all conditions, MVSD had the lowest no-flow fraction. Differences in effective compressions and the no-flow fraction between MVSD and NM did not reach statistical significance. The use of the modified device can improve quality of CPR in a moving ambulance to a level similar to that in a non-moving condition without increasing the severity of back pain.

Numerical simulation of the effect of upstream swirling flow on swirl meter performance

NASA Astrophysics Data System (ADS)

Chen, Desheng; Cui, Baoling; Zhu, Zuchao

2018-04-01

Flow measurement is important in the fluid process and transmission system. For the need of accuracy measurement of fluid, stable flow is acquired. However, the elbows and devices as valves and rotary machines may produce swirling flow in the natural gas pipeline networks system and many other industry fields. In order to reveal the influence of upstream swirling flow on internal flow fields and the metrological characteristics, numerical simulations are carried out on the swirl meter. Using RNG k-ɛ turbulent model and SIMPLE algorithm, the flow field is numerically simulated under swirling flows generated from co-swirl and counter-swirl flow. Simulation results show fluctuation is enhanced or weakened depending on the rotating direction of swirling flow. A counter- swirl flow increases the entropy production rate at the inlet and outlet of the swirler, the junction region between throat and divergent section, and then the pressure loss is increased. The vortex precession dominates the static pressure distributions on the solid walls and in the channel, especially at the end region of the throat.

Method and apparatus for simultaneous determination of fluid mass flow rate, mean velocity and density

DOEpatents

Hamel, William R.

1984-01-01

This invention relates to a new method and new apparatus for determining fluid mass flowrate and density. In one aspect of the invention, the fluid is passed through a straight cantilevered tube in which transient oscillation has been induced, thus generating Coriolis damping forces on the tube. The decay rate and frequency of the resulting damped oscillation are measured, and the fluid mass flowrate and density are determined therefrom. In another aspect of the invention, the fluid is passed through the cantilevered tube while an electrically powered device imparts steady-state harmonic excitation to the tube. This generates Coriolis tube-damping forces which are dependent on the mass flowrate of the fluid. Means are provided to respond to incipient flow-induced changes in the amplitude of vibration by changing the power input to the excitation device as required to sustain the original amplitude of vibration. The fluid mass flowrate and density are determined from the required change in power input. The invention provides stable, rapid, and accurate measurements. It does not require bending of the fluid flow.

Active flow control of subsonic flow in an adverse pressure gradient using synthetic jets and passive micro flow control devices

NASA Astrophysics Data System (ADS)

Denn, Michael E.

Several recent studies have shown the advantages of active and/or passive flow control devices for boundary layer flow modification. Many current and future proposed air vehicles have very short or offset diffusers in order to save vehicle weight and create more optimal vehicle/engine integration. Such short coupled diffusers generally result in boundary layer separation and loss of pressure recovery which reduces engine performance and in some cases may cause engine stall. Deployment of flow control devices can alleviate this problem to a large extent; however, almost all active flow control devices have some energy penalty associated with their inclusion. One potential low penalty approach for enhancing the diffuser performance is to combine the passive flow control elements such as micro-ramps with active flow control devices such as synthetic jets to achieve higher control authority. The goal of this dissertation is twofold. The first objective is to assess the ability of CFD with URANS turbulence models to accurately capture the effects of the synthetic jets and micro-ramps on boundary layer flow. This is accomplished by performing numerical simulations replicating several experimental test cases conducted at Georgia Institute of Technology under the NASA funded Inlet Flow Control and Prediction Technologies Program, and comparing the simulation results with experimental data. The second objective is to run an expanded CFD matrix of numerical simulations by varying various geometric and other flow control parameters of micro-ramps and synthetic jets to determine how passive and active control devices interact with each other in increasing and/or decreasing the control authority and determine their influence on modification of boundary layer flow. The boundary layer shape factor is used as a figure of merit for determining the boundary layer flow quality/modification and its tendency towards separation. It is found by a large number of numerical experiments and the analysis of simulation data that a flow control device's influence on boundary layer quality is a function of three factors: (1) the strength of the longitudinal vortex emanating from the flow control device or devices, (2) the height of the vortex core above the surface and, when a synthetic jet is present, (3) the momentum added to the boundary layer flow.

Flexible Micropost Arrays for Shear Stress Measurement

NASA Technical Reports Server (NTRS)

Wohl, Christopher J.; Palmieri, Frank L.; Hopkins, John W.; Jackson, Allen M.; Connell, John W.; Lin, Yi; Cisotto, Alexxandra A.

2015-01-01

Increased fuel costs, heightened environmental protection requirements, and noise abatement continue to place drag reduction at the forefront of aerospace research priorities. Unfortunately, shortfalls still exist in the fundamental understanding of boundary-layer airflow over aerodynamic surfaces, especially regarding drag arising from skin friction. For example, there is insufficient availability of instrumentation to adequately characterize complex flows with strong pressure gradients, heat transfer, wall mass flux, three-dimensionality, separation, shock waves, and transient phenomena. One example is the acoustic liner efficacy on aircraft engine nacelle walls. Active measurement of shear stress in boundary layer airflow would enable a better understanding of how aircraft structure and flight dynamics affect skin friction. Current shear stress measurement techniques suffer from reliability, complexity, and airflow disruption, thereby compromising resultant shear stress data. The state-of-the-art for shear stress sensing uses indirect or direct measurement techniques. Indirect measurements (e.g., hot-wire, heat flux gages, oil interferometry, laser Doppler anemometry, small scale pressure drag surfaces, i.e., fences) require intricate knowledge of the studied flow, restrictive instrument arrangements, large surface areas, flow disruption, or seeding material; with smaller, higher bandwidth probes under development. Direct measurements involve strain displacement of a sensor element and require no prior knowledge of the flow. Unfortunately, conventional "floating" recessed components for direct measurements are mm to cm in size. Whispering gallery mode devices and Fiber Bragg Gratings are examples of recent additions to this type of sensor with much smaller (?m) sensor components. Direct detection techniques are often single point measurements and difficult to calibrate and implement in wind tunnel experiments. In addition, the wiring, packaging, and installation of delicate micro-electromechanical devices impede the use of most direct shear sensors. Similarly, the cavity required for sensing element displacement is sensitive to particulate obstruction. This work was focused on developing a shear stress sensor for use in subsonic wind tunnel test facilities applicable to an array of test configurations. The non-displacement shear sensors described here have minimal packaging requirements resulting in minimal or no disturbance of boundary layer flow. Compared to previous concepts, device installation could be simple with reduced cost and down-time. The novelty lies in the creation of low profile (nanoscale to 100 µm) micropost arrays that stay within the viscous sub-layer of the airflow. Aerodynamic forces, which are related to the surface shear stress, cause post deflection and optical property changes. Ultimately, a reliable, accurate shear stress sensor that does not disrupt the airflow has the potential to provide high value data for flow physics researchers, aerodynamicists, and aircraft manufacturers leading to greater flight efficiency arising from more in-depth knowledge on how aircraft design impacts near surface properties.

Development and deployment of a passive sampling system in groundwater to characterize the critical zone through isotope tracing

NASA Astrophysics Data System (ADS)

Gal, Frédérick; Négrel, Philippe; Chagué, Bryan

2017-04-01

The Critical Zone (CZ) is the evolving boundary layer where rock, soil, water, air, and living organisms interact, zone controlling the transfer and storage of water and chemical elements. For investigating the CZ, we have developed an integrative sampling system to concentrate the chemical elements in groundwater (CRITEX project). Aims are to measure concentrations and isotopic ratios in groundwater through integrative sampling. In the frame of the groundwater analysis, particularly those located in the critical zone (0-100 m depth), this system makes it possible to create a water flow in a support of passive samplers using Diffusive Gradient in Thin type (DGT) and thus to pre-concentrate the chemical species on a chelating resin by diffusion through a membrane and over a given period in order to facilitate subsequent laboratory measurements. Because DGTs are generally used in surface waters with a high flow rate, the current objective is to create a sufficient flow of water in the sampler to optimize the trapping of elements. Different options and geometries have been modelled by simulation of the flow (agitation of water supplied by a motor and a propeller, pumping ...). The economic model of the device is based on an assembly of commercially available equipment, the novation is based on the support, fully designed in house (patent pending). The device aims to recreate sufficient water flow to avoid the creation of a too large Diffusion Boundary Layer (DBL) on the DGT surface and then to mimic the uptake conditions that prevail in surface waters. The simulations made it possible to optimize the position of the DGT and the velocity of the fluid in order to obtain the maximum flow at its surface and avoid the creation of the DBL. Conditions equivalent to those of a circulation of weakly agitated surface water are thus recreated. The first tests were carried out at lab, in a column simulating a piezometer, including pump, DGT holder and flow meter. Initial functional tests were carried out with tap water to observe the flow of water in the device, to determine the technical characteristics of the system (current, voltage, flow...) and to perform blank measurements to ensure that the device brings no contamination. We then carried out 6 days of immersion of the system on a piezometer of the BRGM site. In parallel, daily sampling was performed using conventional pumping method. Finally, we carried out tests on drillings in the Coët Dan experimental basin (Naizin, Morbihan, France). We established a screening of chemical elements on which isotopic measurements can be done by comparing the accumulated mass in the DGT with respect to the concentration of the elements in water. This suggests that the isotopic determination is possible for U, Sr, Nd and Ni with the exception of Cu and Zn at the moment. Possible contamination of DGTs themselves and/or during field investigations should be further studied in order to rule if Cu or Zn isotope analyses can be foreseen in the future.

Vadose zone water fluxmeter

DOEpatents

Faybishenko, Boris A.

2005-10-25

A Vadose Zone Water Fluxmeter (WFM) or Direct Measurement WFM provides direct measurement of unsaturated water flow in the vadose zone. The fluxmeter is a cylindrical device that fits in a borehole or can be installed near the surface, or in pits, or in pile structures. The fluxmeter is primarily a combination of tensiometers and a porous element or plate in a water cell that is used for water injection or extraction under field conditions. The same water pressure measured outside and inside of the soil sheltered by the lower cylinder of the fluxmeter indicates that the water flux through the lower cylinder is similar to the water flux in the surrounding soil. The fluxmeter provides direct measurement of the water flow rate in the unsaturated soils and then determines the water flux, i.e. the water flow rate per unit area.

Non-contact measurement of helicopter device position in wind tunnels with the use of optical videogrammetry method

NASA Astrophysics Data System (ADS)

Kuruliuk, K. A.; Kulesh, V. P.

2016-10-01

An optical videogrammetry method using one digital camera for non-contact measurements of geometric shape parameters, position and motion of models and structural elements of aircraft in experimental aerodynamics was developed. The tests with the use of this method for measurement of six components (three linear and three angular ones) of real position of helicopter device in wind tunnel flow were conducted. The distance between camera and test object was 15 meters. It was shown in practice that, in the conditions of aerodynamic experiment instrumental measurement error (standard deviation) for angular and linear displacements of helicopter device does not exceed 0,02° and 0.3 mm, respectively. Analysis of the results shows that at the minimum rotor thrust deviations are systematic and generally are within ± 0.2 degrees. Deviations of angle values grow with the increase of rotor thrust.

Post-operative blood loss monitoring device: a new tool for nursing activities.

PubMed

Logier, R; Carette, D; Sozanski, J P; Jeanne, M; Jounwaz, R; De Jonckheere, J

2012-01-01

In most medical specialties, after surgery, it is usual to place a drain at the operative site level, in order to assist the blood flow-out if necessary. This drainage allows avoiding the formation of hematomas and contributes to tissues recovery. However, postoperative blood loss can lead to serious consequences. Also, it is necessary to continuously check the blood output volume in order to be able to intervene quickly in case of too significant losses. In daily clinical practice, this task is due to the nursing staff that periodically records the blood level inside the supple bag connected to the drain. However, this method is not accurate about the volume of lost blood and does not reflect the flow of losses which is an important parameter regarding the evolution of the patient setting. We have designed and developed a prototype of a blood loss monitoring device based on the continuous weight measurement of the blood bag connected to the drain. This device is fixed on the bed and is able to instantaneously alert the medical staff in case of abnormal blood flow-out.

Laser-induced fluorescence detection platform for point-of-care testing

NASA Astrophysics Data System (ADS)

Berner, Marcel; Hilbig, Urs; Schubert, Markus B.; Gauglitz, Günter

2017-08-01

Point-of-care testing (POCT) devices for continuous low-cost monitoring of critical patient parameters require miniaturized and integrated setups for performing quick high-sensitivity analyses, away from central clinical laboratories. This work presents a novel and promising laser-induced fluorescence platform for measurements in direct optical test formats that leads towards such powerful POCT devices based on fluorescence-labeled immunoassays. Ultimate sensitivity of thin film photodetectors, integrated with microfluidics, and a comprehensive optimization of all system components aim at low-level signal detection in the targeted biosensor application. The setup acquires fluorescence signals from the volume of a microfluidic channel. An innovative sandwiching process forms a flow channel in the microfluidic chips by embedding laser-cut double-sided adhesive tapes. The custom fit of amorphous silicon based photodiode arrays to the geometry of the flow channel enables miniaturization, fully adequate for POCT devices. A free-beam laser excitation with line focus provides excellent alignment stability, allows for easy and reliable swapping of the disposable microfluidic chips, and therewith greatly improves the ease of use of the resulting integrated device. As a proof-of-concept of this novel in-volume measurement approach, the limit of detection for the dye DY636-COOH in pure water as a model fluorophore is examined and found to be 26 nmol l-1 .

Power density measurements to optimize AC plasma jet operation in blood coagulation.

PubMed

Ahmed, Kamal M; Eldeighdye, Shaimaa M; Allam, Tarek M; Hassanin, Walaa F

2018-06-14

In this paper, the plasma power density and corresponding plasma dose of a low-cost air non-thermal plasma jet (ANPJ) device are estimated at different axial distances from the nozzle. This estimation is achieved by measuring the voltage and current at the substrate using diagnostic techniques that can be easily made in laboratory; thin wire and dielectric probe, respectively. This device uses a compressed air as input gas instead of the relatively-expensive, large-sized and heavy weighed tanks of Ar or He gases. The calculated plasma dose is found to be very low and allows the presented device to be used in biomedical applications (especially blood coagulation). While plasma active species and charged-particles are found to be the most effective on blood coagulation formation, both air flow and UV, individually, do not have any effect. Moreover, optimal conditions for accelerating blood coagulation are studied. Results showed that, the power density at the substrate is shown to be decreased with increasing the distance from the nozzle. In addition, both distances from nozzle and air flow rate play an important role in accelerating blood coagulation process. Finally, this device is efficient, small-sized, safe enough, of low cost and, hence, has its chances to be wide spread as a first aid and in ambulance.

CPAP Devices for Emergency Prehospital Use: A Bench Study.

PubMed

Brusasco, Claudia; Corradi, Francesco; De Ferrari, Alessandra; Ball, Lorenzo; Kacmarek, Robert M; Pelosi, Paolo

2015-12-01

CPAP is frequently used in prehospital and emergency settings. An air-flow output minimum of 60 L/min and a constant positive pressure are 2 important features for a successful CPAP device. Unlike hospital CPAP devices, which require electricity, CPAP devices for ambulance use need only an oxygen source to function. The aim of the study was to evaluate and compare on a bench model the performance of 3 orofacial mask devices (Ventumask, EasyVent, and Boussignac CPAP system) and 2 helmets (Ventukit and EVE Coulisse) used to apply CPAP in the prehospital setting. A static test evaluated air-flow output, positive pressure applied, and FIO2 delivered by each device. A dynamic test assessed airway pressure stability during simulated ventilation. Efficiency of devices was compared based on oxygen flow needed to generate a minimum air flow of 60 L/min at each CPAP setting. The EasyVent and EVE Coulisse devices delivered significantly higher mean air-flow outputs compared with the Ventumask and Ventukit under all CPAP conditions tested. The Boussignac CPAP system never reached an air-flow output of 60 L/min. The EasyVent had significantly lower pressure excursion than the Ventumask at all CPAP levels, and the EVE Coulisse had lower pressure excursion than the Ventukit at 5, 15, and 20 cm H2O, whereas at 10 cm H2O, no significant difference was observed between the 2 devices. Estimated oxygen consumption was lower for the EasyVent and EVE Coulisse compared with the Ventumask and Ventukit. Air-flow output, pressure applied, FIO2 delivered, device oxygen consumption, and ability to maintain air flow at 60 L/min differed significantly among the CPAP devices tested. Only the EasyVent and EVE Coulisse achieved the required minimum level of air-flow output needed to ensure an effective therapy under all CPAP conditions. Copyright © 2015 by Daedalus Enterprises.

Mach Probe Measurements in a Large-Scale Helicon Plasma

NASA Astrophysics Data System (ADS)

Hatch, M. W.; Kelly, R. F.; Fisher, D. M.; Gilmore, M.; Dwyer, R. H.

2017-10-01

A new six-tipped Mach probe, that utilizes a fused-quartz insulator, has been developed and initially tested in the HelCat dual-source plasma device at the University of New Mexico. The new design allows for relatively long duration measurements of parallel and perpendicular flows that suffer less from thermal changes in conductivity and surface build-up seen in previous alumina-insulated designs. Mach probe measurement will be presented in comparison with ongoing laser induced fluorescence (LIF) measurements, previous Mach probe measurements, ExB flow estimates derived from Langmuir probes, and fast-frame CCD camera images, in an effort to better understand previous anomalous ion flow in HelCat. Additionally, Mach probe-LIF comparisons will provide an experimentally obtained Mach probe calibration constant, K, to validate sheath-derived estimates for the weakly magnetized case. Supported by U.S. National Science Foundation Award 1500423.

Turbo fluid machinery and diffusers

NASA Technical Reports Server (NTRS)

Sakurai, T.

1984-01-01

The general theory behind turbo devices and diffusers is explained. Problems and the state of research on basic equations of flow and experimental and measuring methods are discussed. Conventional centrifugation-type compressor and fan diffusers are considered in detail.

Transient Characteristics of a Fluidic Device for Circulatory Jet Flow.

PubMed

Phan, Hoa Thanh; Dinh, Thien Xuan; Bui, Phong Nhu; Dau, Van Thanh

2018-03-13

In this paper, we report on the design, simulation, and experimental analysis of a miniaturized device that can generate multiple circulated jet flows. The device is actuated by a lead zirconate titanate (PZT) diaphragm. The flows in the device were studied using three-dimensional transient numerical simulation with the programmable open source OpenFOAM and was comparable to the experimental result. Each flow is verified by two hotwires mounted at two positions inside each consisting chamber. The experiment confirmed that the flow was successfully created, and it demonstrated good agreement with the simulation. In addition, a prospective application of the device as an angular rate sensor is also demonstrated. The device is robust, is minimal in size, and can contribute to the development of multi-axis fluidic inertial sensors, fluidic amplifiers, gas mixing, coupling, and analysis.

Transient Characteristics of a Fluidic Device for Circulatory Jet Flow

PubMed Central

Phan, Hoa Thanh; Dinh, Thien Xuan; Bui, Phong Nhu

2018-01-01

In this paper, we report on the design, simulation, and experimental analysis of a miniaturized device that can generate multiple circulated jet flows. The device is actuated by a lead zirconate titanate (PZT) diaphragm. The flows in the device were studied using three-dimensional transient numerical simulation with the programmable open source OpenFOAM and was comparable to the experimental result. Each flow is verified by two hotwires mounted at two positions inside each consisting chamber. The experiment confirmed that the flow was successfully created, and it demonstrated good agreement with the simulation. In addition, a prospective application of the device as an angular rate sensor is also demonstrated. The device is robust, is minimal in size, and can contribute to the development of multi-axis fluidic inertial sensors, fluidic amplifiers, gas mixing, coupling, and analysis. PMID:29534014

A screen-printed flexible flow sensor

NASA Astrophysics Data System (ADS)

Moschos, A.; Syrovy, T.; Syrova, L.; Kaltsas, G.

2017-04-01

A thermal flow sensor was printed on a flexible plastic substrate using exclusively screen-printing techniques. The presented device was implemented with custom made screen-printed thermistors, which allows simple, cost-efficient production on a variety of flexible substrates while maintaining the typical advantages of thermal flow sensors. Evaluation was performed for both static (zero flow) and dynamic conditions using a combination of electrical measurements and IR imaging techniques in order to determine important characteristics, such as temperature response, output repeatability, etc. The flow sensor was characterized utilizing the hot-wire and calorimetric principles of operation, while the preliminary results appear to be very promising, since the sensor was successfully evaluated and displayed adequate sensitivity in a relatively wide flow range.

Study of Plasma Flows Generated in Plasma Focus Discharge in Different Regimes of Working Gas Filling

NASA Astrophysics Data System (ADS)

Voitenko, D. A.; Ananyev, S. S.; Astapenko, G. I.; Basilaia, A. D.; Markolia, A. I.; Mitrofanov, K. N.; Myalton, V. V.; Timoshenko, A. P.; Kharrasov, A. M.; Krauz, V. I.

2017-12-01

Results are presented from experimental studies of the plasma flows generated in the KPF-4 Phoenix Mather-type plasma focus device (Sukhum Physical Technical Institute). In order to study how the formation and dynamics of the plasma flow depend on the initial distribution of the working gas, a system of pulsed gas puffing into the discharge volume was developed. The system allows one to create profiled gas distributions, including those with a reduced gas density in the region of plasma flow propagation. Results of measurements of the magnetic field, flow profile, and flow deceleration dynamics at different initial distributions of the gas pressure are presented.

Classification of biological cells using a sound wave based flow cytometer

NASA Astrophysics Data System (ADS)

Strohm, Eric M.; Gnyawali, Vaskar; Van De Vondervoort, Mia; Daghighi, Yasaman; Tsai, Scott S. H.; Kolios, Michael C.

2016-03-01

A flow cytometer that uses sound waves to determine the size of biological cells is presented. In this system, a microfluidic device made of polydimethylsiloxane (PDMS) was developed to hydrodynamically flow focus cells in a single file through a target area. Integrated into the microfluidic device was an ultrasound transducer with a 375 MHz center frequency, aligned opposite the transducer was a pulsed 532 nm laser focused into the device by a 10x objective. Each passing cell was insonfied with a high frequency ultrasound pulse, and irradiated with the laser. The resulting ultrasound and photoacoustic waves from each cell were analyzed using signal processing methods, where features in the power spectra were compared to theoretical models to calculate the cell size. Two cell lines with different size distributions were used to test the system: acute myeloid leukemia cells (AML) and melanoma cells. Over 200 cells were measured using this system. The average calculated diameter of the AML cells was 10.4 +/- 2.5 μm using ultrasound, and 11.4 +/- 2.3 μm using photoacoustics. The average diameter of the melanoma cells was 16.2 +/- 2.9 μm using ultrasound, and 18.9 +/- 3.5 μm using photoacoustics. The cell sizes calculated using ultrasound and photoacoustic methods agreed with measurements using a Coulter Counter, where the AML cells were 9.8 +/- 1.8 μm and the melanoma cells were 16.0 +/- 2.5 μm. These results demonstrate a high speed method of assessing cell size using sound waves, which is an alternative method to traditional flow cytometry techniques.

Combined Laser-Doppler Flowmetry and Spectrophotometry: Feasibility Study of a Novel Device for Monitoring Local Cortical Microcirculation during Aneurysm Surgery.

PubMed

Sommer, Björn; Kreuzer, Maximilian; Bischoff, Barbara; Wolf, Dennis; Schmitt, Hubert; Eyupoglu, Ilker Y; Rössler, Karl; Buchfelder, Michael; Ganslandt, Oliver; Wiendieck, Kurt

2017-01-01

Background  Monitoring of cortical cerebral perfusion is essential, especially in neurovascular surgery. Study Aims  To test a novel noninvasive laser-Doppler flowmetry and spectrophotometry device for feasibility during elective cerebral aneurysm surgery. Material and Methods  In this prospective single-institution nonrandomized trial, we studied local cerebral microcirculation using the noninvasive laser-Doppler spectrophotometer "Oxygen-to-see" (O2C) in 20 consecutive patients (15 female, 5 male; median age: 60.5 ± 11.7 years) who were operated on for incidental cerebral aneurysms. Capillary-venous oxygenation (oxygen saturation ["SO 2 "]), postcapillary venous filling pressures (relative hemoglobin content ["rHb"]), blood cell velocity ("velo"), and blood flow ("flow") were measured in 7-mm tissue depth using a subdural fiberoptic probe. Results  Representative recordings were acquired immediately after dural opening over a median time span of 88 ± 21.8 seconds (range: 60-128 seconds) before surgical manipulation. Baseline values (median ± 2 standard deviations) of brain perfusion as measured with the O2C device were SO 2 , 39 ± 16.6%; rHb, 53 ± 18.6 arbitrary units (AU); velo, 60 ± 20.4 AU; and flow, 311 ± 72.8 AU. Placement of the self-retaining retractor led to a decrease in SO 2 of 17% ± 29% ( p  < .05) and flow of 10% ± 11% ( p  < .01); rHb increased by 18% ± 20% ( p  < .01), and velo remained unchanged. Retractor removal caused the opposite with an increased flow of 10% ± 7% ( p  < 0.001) and velo (3% ± 6%, p  = 0.11), but a decrease in SO 2 of 24% ± 33% ( p  = 0.09) and rHb of 12% ± 20% ( p =0.18). No neurologic or surgical complications occurred. Conclusion  Using this novel noninvasive system, we were able to measure local cerebral microcirculation during aneurysm surgery. Our data indicate that this device is able to detect changes during routine neurosurgical maneuvers. Thus it may be useful for early detection of cerebral microcirculatory disturbances. Georg Thieme Verlag KG Stuttgart · New York.

Novel silicon microchannels device for use in red blood cell deformability studies

NASA Astrophysics Data System (ADS)

Zheng, Xiao-Lin; Liao, Yan-Jian; Zhang, Wen-Xian

2001-10-01

Currently, a number of techniques are used to access cell deformability. We study a novel silicon microchannels device for use in red blood cell deformability. The channels are produced in silicon substrate using microengineering technology. The microgrooves formed in the surface of a single-crystal silicon substrate. They were converted to channels by tightly covering them with an optical flat glass plate. An array of flow channels (number 950 in parallel) have typical dimensions of 5 micrometers width X 5.5 Xm depth, and 30 micrometers length. There the RBC's are forced to pass through channels. Thus, the microchannels are used to simulate human blood capillaries. It provides a specific measurement of individual cell in terms of both flow velocity profile and an index of cell volume while the cell flow through the channels. It dominates the complex cellular flow behavior, such as, the viscosity of whole blood is a nonlinear function of shear rate, index of filtration, etc.

PIV investigation of the flow induced by a passive surge control method in a radial compressor

NASA Astrophysics Data System (ADS)

Guillou, Erwann; Gancedo, Matthieu; Gutmark, Ephraim; Mohamed, Ashraf

2012-09-01

Due to recent emission regulations, the use of turbochargers for force induction of internal combustion engines has increased. Actually, the trend in diesel engines is to downsize the engine by use of turbochargers that operate at higher pressure ratios. Unfortunately, increasing the impeller rotational speed of turbocharger radial compressors tends to reduce their range of operation, which is limited at low mass flow rate by the occurrence of surge. In order to extend the operability of turbochargers, compressor housings can be equipped with a passive surge control device such as a "ported shroud." This specific casing treatment has been demonstrated to enhance the surge margin with minor negative impact on the compressor efficiency. However, the actual working mechanisms of the system remain not well understood. Hence, in order to optimize the design of the ported shroud, it is crucial to identify the dynamic flow changes induced by the implementation of the device to control instabilities. From the full dynamic survey of the compressor performance characteristics obtained with and without ported shroud, specific points of operation were selected to carry out planar flow visualization. At normal working, both standard and stereoscopic particle imaging velocimetry (PIV) measurements were performed to evaluate instantaneous and mean velocity flow fields at the inlet of the compressor. At incipient and full surge, phase-locked PIV measurements were added. As a result, satisfying characterization of the compressor instabilities was provided at different operational speeds. Combining transient pressure data and PIV measurements, the time evolution of the complex flow patterns occurring at surge was reconstructed and a better insight into the bypass mechanism was achieved.

Capacitance measuring device

DOEpatents

Andrews, W.H. Jr.

1984-08-01

A capacitance measuring circuit is provided in which an unknown capacitance is measured by comparing the charge stored in the unknown capacitor with that stored in a known capacitance. Equal and opposite voltages are repetitively simultaneously switched onto the capacitors through an electronic switch driven by a pulse generator to charge the capacitors during the ''on'' portion of the cycle. The stored charge is compared by summing discharge currents flowing through matched resistors at the input of a current sensor during the ''off'' portion of the switching cycle. The net current measured is thus proportional to the difference in value of the two capacitances. The circuit is capable of providing much needed accuracy and stability to a great variety of capacitance-based measurement devices at a relatively low cost.

Modeling, fabrication and plasma actuator coupling of flexible pressure sensors for flow separation detection and control in aeronautical applications

NASA Astrophysics Data System (ADS)

Francioso, L.; De Pascali, C.; Pescini, E.; De Giorgi, M. G.; Siciliano, P.

2016-06-01

Preventing the flow separation could enhance the performance of propulsion systems and future civil aircraft. To this end, a fast detection of boundary layer separation is mandatory for a sustainable and successful application of active flow control devices, such as plasma actuators. The present work reports on the design, fabrication and functional tests of low-cost capacitive pressure sensors coupled with dielectric barrier discharge (DBD) plasma actuators to detect and then control flow separation. Finite element method (FEM) simulations were used to obtain information on the deflection and the stress distribution in different-shaped floating membranes. The sensor sensitivity as a function of the pressure load was also calculated by experimental tests. The results of the calibration of different capacitive pressure sensors are reported in this work, together with functional tests in a wind tunnel equipped with a curved wall plate on which a DBD plasma actuator was mounted to control the flow separation. The flow behavior was experimentally investigated by particle image velocimetry (PIV) measurements. Statistical and spectral analysis, applied to the output signals of the pressure sensor placed downstream of the profile leading edge, demonstrated that the sensor is able to discriminate different ionic wind velocity and turbulence conditions. The sensor sensitivity in the 0-100 Pa range was experimentally measured and it ranged between 0.0030 and 0.0046 pF Pa-1 for the best devices.

Perceptual analysis of vibrotactile flows on a mobile device.

PubMed

Seo, Jongman; Choi, Seungmoon

2013-01-01

"Vibrotactile flow" refers to a continuously moving sensation of vibrotactile stimulation applied by a few actuators directly onto the skin or through a rigid medium. Research demonstrated the effectiveness of vibrotactile flow for conveying intuitive directional information on a mobile device. In this paper, we extend previous research by investigating the perceptual characteristics of vibrotactile flows rendered on a mobile device and proposing a synthesis framework for vibrotactile flows with desired perceptual properties.

Conformal mapping in optical biosensor applications.

PubMed

Zumbrum, Matthew E; Edwards, David A

2015-09-01

Optical biosensors are devices used to investigate surface-volume reaction kinetics. Current mathematical models for reaction dynamics rely on the assumption of unidirectional flow within these devices. However, new devices, such as the Flexchip, include a geometry that introduces two-dimensional flow, complicating the depletion of the volume reactant. To account for this, a previous mathematical model is extended to include two-dimensional flow, and the Schwarz-Christoffel mapping is used to relate the physical device geometry to that for a device with unidirectional flow. Mappings for several Flexchip dimensions are considered, and the ligand depletion effect is investigated for one of these mappings. Estimated rate constants are produced for simulated data to quantify the inclusion of two-dimensional flow in the mathematical model.

Breathing simulator of workers for respirator performance test

PubMed Central

YUASA, Hisashi; KUMITA, Mikio; HONDA, Takeshi; KIMURA, Kazushi; NOZAKI, Kosuke; EMI, Hitoshi; OTANI, Yoshio

2014-01-01

Breathing machines are widely used to evaluate respirator performance but they are capable of generating only limited air flow patterns, such as, sine, triangular and square waves. In order to evaluate the respirator performance in practical use, it is desirable to test the respirator using the actual breathing patterns of wearers. However, it has been a difficult task for a breathing machine to generate such complicated flow patterns, since the human respiratory volume changes depending on the human activities and workload. In this study, we have developed an electromechanical breathing simulator and a respiration sampling device to record and reproduce worker’s respiration. It is capable of generating various flow patterns by inputting breathing pattern signals recorded by a computer, as well as the fixed air flow patterns. The device is equipped with a self-control program to compensate the difference in inhalation and exhalation volume and the measurement errors on the breathing flow rate. The system was successfully applied to record the breathing patterns of workers engaging in welding and reproduced the breathing patterns. PMID:25382381

Micro-fabricated DC comparison calorimeter for RF power measurement.

PubMed

Neji, Bilel; Xu, Jing; Titus, Albert H; Meltzer, Joel

2014-10-27

Diode detection and bolometric detection have been widely used to measure radio frequency (RF) power. However, flow calorimeters, in particular micro-fabricated flow calorimeters, have been mostly unexplored as power meters. This paper presents the design, micro-fabrication and characterization of a flow calorimeter. This novel device is capable of measuring power from 100 μW to 200 mW. It has a 50-Ohm load that is heated by the RF source, and the heat is transferred to fluid in a microchannel. The temperature change in the fluid is measured by a thermistor that is connected in one leg of a Wheatstone bridge. The output voltage change of the bridge corresponds to the RF power applied to the load. The microfabricated device measures 25.4 mm × 50.8 mm, excluding the power supplies, microcontroller and fluid pump. Experiments demonstrate that the micro-fabricated sensor has a sensitivity up to 22 × 10⁻³ V/W. The typical resolution of this micro-calorimeter is on the order of 50 μW, and the best resolution is around 10 μW. The effective efficiency is 99.9% from 0−1 GHz and more than 97.5% at frequencies up to 4 GHz. The measured reflection coefficient of the 50-Ohm load and coplanar wave guide is less than −25 dB from 0−2 GHz and less than −16 dB at 2−4 GHz.

A high sensitivity momentum flux measuring instrument for plasma thruster exhausts and diffusive plasmas.

PubMed

West, Michael D; Charles, Christine; Boswell, Rod W

2009-05-01

A high sensitivity momentum flux measuring instrument based on a compound pendulum has been developed for use with electric propulsion devices and radio frequency driven plasmas. A laser displacement system, which builds upon techniques used by the materials science community for surface stress measurements, is used to measure with high sensitivity the displacement of a target plate placed in a plasma thruster exhaust. The instrument has been installed inside a vacuum chamber and calibrated via two different methods and is able to measure forces in the range of 0.02-0.5 mN with a resolution of 15 microN. Measurements have been made of the force produced from the cold gas flow and with a discharge ignited using argon propellant. The plasma is generated using a Helicon Double Layer Thruster prototype. The instrument target is placed about 1 mean free path for ion-neutral charge exchange collisions downstream of the thruster exit. At this position, the plasma consists of a low density ion beam (10%) and a much larger downstream component (90%). The results are in good agreement with those determined from the plasma parameters measured with diagnostic probes. Measurements at various flow rates show that variations in ion beam velocity and plasma density and the resulting momentum flux can be measured with this instrument. The instrument target is a simple, low cost device, and since the laser displacement system used is located outside the vacuum chamber, the measurement technique is free from radio frequency interference and thermal effects. It could be used to measure the thrust in the exhaust of other electric propulsion devices and the momentum flux of ion beams formed by expanding plasmas or fusion experiments.

Pyrophoric behaviour of uranium hydride and uranium powders

NASA Astrophysics Data System (ADS)

Le Guyadec, F.; Génin, X.; Bayle, J. P.; Dugne, O.; Duhart-Barone, A.; Ablitzer, C.

2010-01-01

Thermal stability and spontaneous ignition conditions of uranium hydride and uranium metal fine powders have been studied and observed in an original and dedicated experimental device placed inside a glove box under flowing pure argon. Pure uranium hydride powder with low amount of oxide (<0.5 wt.%) was obtained by heat treatment at low temperature in flowing Ar/5%H2. Pure uranium powder was obtained by dehydration in flowing pure argon. Those fine powders showed spontaneous ignition at room temperature in air. An in situ CCD-camera displayed ignition associated with powder temperature measurement. Characterization of powders before and after ignition was performed by XRD measurements and SEM observations. Oxidation mechanisms are proposed.

Biomimetics of fetal alveolar flow phenomena using microfluidics.

PubMed

Tenenbaum-Katan, Janna; Fishler, Rami; Rothen-Rutishauser, Barbara; Sznitman, Josué

2015-01-01

At the onset of life in utero, the respiratory system begins as a liquid-filled tubular organ and undergoes significant morphological changes during fetal development towards establishing a respiratory organ optimized for gas exchange. As airspace morphology evolves, respiratory alveolar flows have been hypothesized to exhibit evolving flow patterns. In the present study, we have investigated flow topologies during increasing phases of embryonic life within an anatomically inspired microfluidic device, reproducing real-scale features of fetal airways representative of three distinct phases of in utero gestation. Micro-particle image velocimetry measurements, supported by computational fluid dynamics simulations, reveal distinct respiratory alveolar flow patterns throughout different stages of fetal life. While attached, streamlined flows characterize the shallow structures of premature alveoli indicative of the onset of saccular stage, separated recirculating vortex flows become the signature of developed and extruded alveoli characteristic of the advanced stages of fetal development. To further mimic physiological aspects of the cellular environment of developing airways, our biomimetic devices integrate an alveolar epithelium using the A549 cell line, recreating a confluent monolayer that produces pulmonary surfactant. Overall, our in vitro biomimetic fetal airways model delivers a robust and reliable platform combining key features of alveolar morphology, flow patterns, and physiological aspects of fetal lungs developing in utero.

Novel multi-functional fluid flow device for studying cellular mechanotransduction

PubMed Central

Lyons, James S.; Iyer, Shama R.; Lovering, Richard M.; Ward, Christopher W.; Stains, Joseph P.

2016-01-01

Cells respond to their mechanical environment by initiating multiple mechanotransduction signaling pathways. Defects in mechanotransduction have been implicated in a number of pathologies; thus, there is need for convenient and efficient methods for studying the mechanisms underlying these processes. A widely used and accepted technique for mechanically stimulating cells in culture is the introduction of fluid flow on cell monolayers. Here, we describe a novel, multifunctional fluid flow device for exposing cells to fluid flow in culture. This device integrates with common lab equipment including routine cell culture plates and peristaltic pumps. Further, it allows the fluid flow treated cells to be examined with outcomes at the cell and molecular level. We validated the device using the biologic response of cultured UMR-106 osteoblast-like cells in comparison to a commercially available system of laminar sheer stress to track live cell calcium influx in response to fluid flow. In addition, we demonstrate the fluid flow-dependent activation of phospho-ERK in these cells, consistent with the findings in other fluid flow devices. This device provides a low cost, multi-functional alternative to currently available systems, while still providing the ability to generate physiologically relevant conditions for studying processes involved in mechanotransduction in vitro. PMID:27887728

Investigation of Impact Jets Flow in Heat Sink Device of Closed-Circuit Cooling Systems

NASA Astrophysics Data System (ADS)

Tokarev, D. A.; Yenivatov, V. V.; Sokolov, S. S.; Erofeev, V. L.

2018-03-01

The flow simulations of impact jets in the heat sink device of the closed-circuit cooling systems are presented. The analysis of the rate of fluid flow in the heat sink device with the jet supply coolant is given.

Electrokinetic transport phenomena: Mobility measurement and electrokinetic instability

NASA Astrophysics Data System (ADS)

Oddy, Michael Huson

Miniaturization and integration of traditional bioassay procedures into microfabricated on-chip assay systems, commonly referred to as "Micro Total Analysis" (muTAS) systems, may have a significant impact on the fields of genomics, proteomics, and clinical analysis. These bioanalytical microsystems leverage electroosmosis and electrophoresis for sample transport, mixing, manipulation, and separation. This dissertation addresses the following three topics relevant to such systems: a new diagnostic for measuring the electrophoretic mobility of sub-micron, fluorescently-labeled particles and the electroosmotic mobility of a microchannel; a novel method and device for rapidly stirring micro- and nanoliter volume solutions for microfluidic bioanalytical applications; and a multiple-species electrokinetic instability model. Accurate measurement of the electrophoretic particle mobility and the electroosmotic mobility of microchannel surfaces is crucial to understanding the stability of colloidal suspensions, obtaining particle tracking-based velocimetry measurements of electroosmotic flow fields, and the quantification of electrokinetic bioanalytical device performance. A method for determining these mobilities from alternating and direct current electrokinetic particle tracking measurements is presented. The ability to rapidly mix fluids at low Reynolds numbers is important to the functionality of many bioanalytical, microfluidic devices. We present an electrokinetic process for rapidly stirring microflow streams by initiating an electrokinetic flow instability. The design, fabrication and performance analysis of two micromixing devices capable of rapidly stirring two low Reynolds number fluid streams are presented. Electroosmotic and electrophoretic transport in the presence of conductivity mismatches between reagent streams and the background electrolytes, can lead to an unstable flow field generating significant sample dispersion. In the multiple-species electrokinetic instability model, we consider a high aspect ratio microchannel geometry, a conductivity gradient orthogonal to the applied electric field, and a four-species chemistry model. A linear stability analysis of the depth-averaged governing equations shows unstable eigenmodes for conductivity ratios as close to unity as 1.01. Experiments and full nonlinear simulations of the governing equations were conducted for a conductivity ratio of 1.05. Images of the disturbance dye field from the nonlinear simulations show good qualitative and quantitative agreement with experiment. Species electromigration is shown to a have significant influence on the development of the conductivity field and instability dynamics in multi-ion configurations.

Computation of records of streamflow at control structures

USGS Publications Warehouse

Collins, Dannie L.

1977-01-01

Traditional methods of computing streamflow records on large, low-gradient streams require a continuous record of water-surface slope over a natural channel reach. This slope must be of sufficient magnitude to be accuratly measured with available stage measuring devices. On highly regulated streams, this slope approaches zero during periods of low flow and accurate measurement is difficult. Methods are described to calibrate multipurpose regulating control structures to more accurately compute streamflow records on highly-regulated streams. Hydraulic theory, assuming steady, uniform flow during a computational interval, is described for five different types of flow control. The controls are: Tainter gates, hydraulic turbines, fixed spillways, navigation locks, and crest gates. Detailed calibration procedures are described for the five different controls as well as for several flow regimes for some of the controls. The instrumentation package and computer programs necessary to collect and process the field data are discussed. Two typical calibration procedures and measurement data are presented to illustrate the accuracy of the methods. (Woodard-USGS)

Renal embolic protection devices improve blood flow after stenting for atherosclerotic renal artery stenosis.

PubMed

Paul, Timir K; Lee, John H; White, Christopher J

2012-11-15

We sought to measure angiographic renal frame counts (RFC), as a quantitative angiographic assessment of renal blood flow, to evaluate microvascular compromise due to atheroembolism associated with RAS. Atheroembolism associated with renal artery stenting (RAS) has been implicated as a cause for worsening renal function following successful intervention. Use of a distal embolic protection device (EPD) during RAS has been shown to be safe with debris capture in a high percentage of cases. However, objective benefit for renal function with EPD has been difficult to demonstrate. A control group of 30 consecutive patients (33 kidneys) who underwent RAS without EPD were compared with 33 consecutive patients (33 kidneys) who underwent RAS with EPD using RFC measurement. The prestent and poststent mean RFC for the control group was 30.4 ± 12.1 vs. 23.7 ± 9.9 (P = 0.002) and for the EPD group it was 42.6 ± 12.6 vs. 28.3 ± 9.2 (P < 0.0001). The EPD group had a greater improvement in renal blood flow, manifested by a greater reduction of the RFC (Δ RFC) 14.2 ± 15.2 vs. 6.7 ± 11.7 (P = 0.03) compared with the control group. The use of an EPD was associated with a much larger improvement in renal blood flow (lower RFC) following RAS. This suggests that EPD's may be effective in preventing renal atheroembolic injury and that a controlled trial measuring the impact of EPD's on renal blood flow following RAS should be performed. Copyright © 2012 Wiley Periodicals, Inc.

Continuous-Flow Left Ventricular Assist Device Support Improves Myocardial Supply:Demand in Chronic Heart Failure.

PubMed

Soucy, Kevin G; Bartoli, Carlo R; Phillips, Dustin; Giridharan, Guruprasad A; Sobieski, Michael A; Wead, William B; Dowling, Robert D; Wu, Zhongjun J; Prabhu, Sumanth D; Slaughter, Mark S; Koenig, Steven C

2017-06-01

Continuous-flow left ventricular assist devices (CF LVADs) are rotary blood pumps that improve mean blood flow, but with potential limitations of non-physiological ventricular volume unloading and diminished vascular pulsatility. In this study, we tested the hypothesis that left ventricular unloading with increasing CF LVAD flow increases myocardial flow normalized to left ventricular work. Healthy (n = 8) and chronic ischemic heart failure (IHF, n = 7) calves were implanted with CF LVADs. Acute hemodynamics and regional myocardial blood flow were measured during baseline (LVAD off, clamped), partial (2-4 L/min) and full (>4 L/min) LVAD support. IHF calves demonstrated greater reduction of cardiac energy demand with increasing LVAD support compared to healthy calves, as calculated by rate-pressure product. Coronary artery flows (p < 0.05) and myocardial blood flow (left ventricle (LV) epicardium and myocardium, p < 0.05) decreased with increasing LVAD support in normal calves. In the IHF model, blood flow to the septum, LV, LV epicardium, and LV myocardium increased significantly with increasing LVAD support when normalized to cardiac energy demand (p < 0.05). In conclusion, myocardial blood flow relative to cardiac demand significantly increased in IHF calves, thereby demonstrating that CF LVAD unloading effectively improves cardiac supply and demand ratio in the setting of ischemic heart failure.

Left Atrial Pressure Monitoring With an Implantable Wireless Pressure Sensor After Implantation of a Left Ventricular Assist Device

PubMed Central

Baranowski, Jacek; Delshad, Baz; Ahn, Henrik

2017-01-01

After implantation of a continuous-flow left ventricular assist device (LVAD), left atrial pressure (LAP) monitoring allows for the precise management of intravascular volume, inotropic therapy, and pump speed. In this case series of 4 LVAD recipients, we report the first clinical use of this wireless pressure sensor for the long-term monitoring of LAP during LVAD support. A wireless microelectromechanical system pressure sensor (Titan, ISS Inc., Ypsilanti, MI) was placed in the left atrium in four patients at the time of LVAD implantation. Titan sensor LAP was measured in all four patients on the intensive care unit and in three patients at home. Ramped speed tests were performed using LAP and echocardiography in three patients. The left ventricular end-diastolic diameter (cm), flow (L/min), power consumption (W), and blood pressure (mm Hg) were measured at each step. Measurements were performed over 36, 84, 137, and 180 days, respectively. The three discharged patients had equipment at home and were able to perform daily recordings. There were significant correlations between sensor pressure and pump speed, LV and LA size and pulmonary capillary wedge pressure, respectively (r = 0.92–0.99, p < 0.05). There was no device failure, and there were no adverse consequences of its use. PMID:27676410

Quantitative real-time in vivo detection of magnetic nanoparticles by their nonlinear magnetization

NASA Astrophysics Data System (ADS)

Nikitin, M. P.; Torno, M.; Chen, H.; Rosengart, A.; Nikitin, P. I.

2008-04-01

A novel method of highly sensitive quantitative detection of magnetic nanoparticles (MP) in biological tissues and blood system has been realized and tested in real time in vivo experiments. The detection method is based on nonlinear magnetic properties of MP and the related device can record a very small relative variation of nonlinear magnetic susceptibility up to 10-8 at room temperature, providing sensitivity of several nanograms of MP in 0.1ml volume. Real-time quantitative in vivo measurements of dynamics of MP concentration in blood flow have been performed. A catheter that carried the blood flow of a rat passed through the measuring device. After an MP injection, the quantity of MP in the circulating blood was continuously recorded. The method has also been used to evaluate the MP distribution between rat's organs. Its sensitivity was compared with detection of the radioactive MP based on isotope of Fe59. The comparison of magnetic and radioactive signals in the rat's blood and organ samples demonstrated similar sensitivity for both methods. However, the proposed magnetic method is much more convenient as it is safe, less expensive, and provides real-time measurements in vivo. Moreover, the sensitivity of the method can be further improved by optimization of the device geometry.

A systematic approach for the accurate and rapid measurement of water vapor transmission through ultra-high barrier films

NASA Astrophysics Data System (ADS)

Kiese, Sandra; Kücükpinar, Esra; Reinelt, Matthias; Miesbauer, Oliver; Ewender, Johann; Langowski, Horst-Christian

2017-02-01

Flexible organic electronic devices are often protected from degradation by encapsulation in multilayered films with very high barrier properties against moisture and oxygen. However, metrology must be improved to detect such low quantities of permeants. We therefore developed a modified ultra-low permeation measurement device based on a constant-flow carrier-gas system to measure both the transient and stationary water vapor permeation through high-performance barrier films. The accumulation of permeated water vapor before its transport to the detector allows the measurement of very low water vapor transmission rates (WVTRs) down to 2 × 10-5 g m-2 d-1. The measurement cells are stored in a temperature-controlled chamber, allowing WVTR measurements within the temperature range 23-80 °C. Differences in relative humidity can be controlled within the range 15%-90%. The WVTR values determined using the novel measurement device agree with those measured using a commercially available carrier-gas device from MOCON®. Depending on the structure and quality of the barrier film, it may take a long time for the WVTR to reach a steady-state value. However, by using a combination of the time-dependent measurement and the finite element method, we were able to estimate the steady-state WVTR accurately with significantly shorter measurement times.

Droplet microfluidics driven by gradients of confinement.

PubMed

Dangla, Rémi; Kayi, S Cagri; Baroud, Charles N

2013-01-15

The miniaturization of droplet manipulation methods has led to drops being proposed as microreactors in many applications of biology and chemistry. In parallel, microfluidic methods have been applied to generate monodisperse emulsions for applications in the pharmaceuticals, cosmetics, and food industries. To date, microfluidic droplet production has been dominated by a few designs that use hydrodynamic forces, resulting from the flowing fluids, to break drops at a junction. Here we present a platform for droplet generation and manipulation that does not depend on the fluid flows. Instead, we use devices that incorporate height variations to subject the immiscible interfaces to gradients of confinement. The resulting curvature imbalance along the interface causes the detachment of monodisperse droplets, without the need for a flow of the external phase. Once detached, the drops are self-propelled due to the gradient of surface energy. We show that the size of the drops is determined by the device geometry; it is insensitive to the physical fluid properties and depends very weakly on the flow rate of the dispersed phase. This allows us to propose a geometric theoretical model that predicts the dependence of droplet size on the geometric parameters, which is in agreement with experimental measurements. The approach presented here can be applied in a wide range of standard applications, while simplifying the device operations. We demonstrate examples for single-droplet operations and high-throughput generation of emulsions, all of which are performed in simple and inexpensive devices.

Droplet microfluidics driven by gradients of confinement

PubMed Central

Dangla, Rémi; Kayi, S. Cagri; Baroud, Charles N.

2013-01-01

The miniaturization of droplet manipulation methods has led to drops being proposed as microreactors in many applications of biology and chemistry. In parallel, microfluidic methods have been applied to generate monodisperse emulsions for applications in the pharmaceuticals, cosmetics, and food industries. To date, microfluidic droplet production has been dominated by a few designs that use hydrodynamic forces, resulting from the flowing fluids, to break drops at a junction. Here we present a platform for droplet generation and manipulation that does not depend on the fluid flows. Instead, we use devices that incorporate height variations to subject the immiscible interfaces to gradients of confinement. The resulting curvature imbalance along the interface causes the detachment of monodisperse droplets, without the need for a flow of the external phase. Once detached, the drops are self-propelled due to the gradient of surface energy. We show that the size of the drops is determined by the device geometry; it is insensitive to the physical fluid properties and depends very weakly on the flow rate of the dispersed phase. This allows us to propose a geometric theoretical model that predicts the dependence of droplet size on the geometric parameters, which is in agreement with experimental measurements. The approach presented here can be applied in a wide range of standard applications, while simplifying the device operations. We demonstrate examples for single-droplet operations and high-throughput generation of emulsions, all of which are performed in simple and inexpensive devices. PMID:23284169

The impact of airway management on quality of cardiopulmonary resuscitation: an observational study in patients during cardiac arrest.

PubMed

Yeung, Joyce; Chilwan, Mehboob; Field, Richard; Davies, Robin; Gao, Fang; Perkins, Gavin D

2014-07-01

Minimising interruptions in chest compressions is associated with improved survival from cardiac arrest. Current in-hospital guidelines recommend continuous chest compressions after the airway is secured on the premise that this will reduce no flow time. The aim of this study was to determine the effect of advanced airway use on the no flow ratio and other measures of CPR quality. Consecutive adult patients who sustained an in-hospital cardiac arrest were enrolled in this prospective observational study. The quality of CPR was measured using the Q-CPR device (Phillips, UK) before and after an advanced airway device (endotracheal tube [ET] or laryngeal mask airway [LMA]) was inserted. Patients receiving only bag-mask ventilation were used as the control cohort. The primary outcome was no flow ratio (NFR). Secondary outcomes were chest compression rate, depth, compressions too shallow, compressions with leaning, ventilation rate, inflation time, change in impedance and time required to successfully insert airway device. One hundred patients were enrolled in the study (2008-2011). Endotracheal tube and LMA placement took similar durations (median 15.8 s (IQR 6.8-19.4) vs. LMA median 8.0s (IQR 5.5-15.9), p=0.1). The use of an advanced airway was associated with improved no flow ratios (endotracheal tube placement (n=50) improved NFR from baseline median 0.24 IQR 0.17-0.40) to 0.15 to (IQR 0.09-0.28), p=0.012; LMA (n=25) from median 0.28 (IQR 0.23-0.40) to 0.13 (IQR 0.11- 0.19), p=0.0001). There was no change in NFR in patients managed solely with bag valve mask (BVM) (n=25) (median 0.29 (IQR 0.18-0.59) vs. median 0.26 (IQR 0.12-0.37), p=0.888). There was no significant difference in time taken to successfully insert the airway device between the two groups. The use of an advanced airway (ETT or LMA) during in-hospital cardiac arrest was associated with improved no flow ratio. Further studies are required to determine the effect of airway devices on overall patient outcomes. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Analyzing Conductivity Profiles in Stream Waters Influenced by Mine Water Discharges

NASA Astrophysics Data System (ADS)

Räsänen, Teemu; Hämäläinen, Emmy; Hämäläinen, Matias; Turunen, Kaisa; Pajula, Pasi; Backnäs, Soile

2015-04-01

Conductivity is useful as a general measure of stream water quality. Each stream inclines to have a quite constant range of conductivity that can be used as a baseline for comparing and detecting influence of contaminant sources. Conductivity in natural streams and rivers is affected primarily by the geology of the watershed. Thus discharges from ditches and streams affect not only the flow rate in the river but also the water quality and conductivity. In natural stream waters, the depth and the shape of the river channel change constantly, which changes also the water flow. Thus, an accurate measuring of conductivity or other water quality indicators is difficult. Reliable measurements are needed in order to have holistic view about amount of contaminants, sources of discharges and seasonal variation in mixing and dilution processes controlling the conductivity changes in river system. We tested the utility of CastAway-CTD measuring device (SonTek Inc) to indicate the influence of mine waters as well as mixing and dilution occurring in the recipient river affected by treated dewatering and process effluent water discharges from a Finnish gold mine. The CastAway-CTD measuring device is a small, rugged and designed for profiling of depths of up to 100m. Device measures temperature, salinity, conductivity and sound of speed using 5 Hz response time. It has also built-in GPS which produces location information. CTD casts are normally used to produce vertical conductivity profile for rather deep waters like seas or lakes. We did seasonal multiple Castaway-CTD measurements during 2013 and 2014 and produced scaled vertical and horizontal profiles of conductivity and water temperature at the river. CastAway-CTD measurement pinpoints how possible contaminants behave and locate in stream waters. The conductivity profiles measured by CastAway-CTD device show the variation in maximum conductivity values vertically in measuring locations and horizontally in measured cross-sections. The data from field measurements was combined with detailed water quality analysis and processed by data analysis with Matlab to produce more holistic information about the behavior, mixing and dilution of possible contaminants at the river. Moreover, the results can be used to improve water sampling procedures for more representative sampling and to plan continuous monitoring site locations and measuring device mounting places.

21 CFR 870.1240 - Flow-directed catheter.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Flow-directed catheter. 870.1240 Section 870.1240 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES CARDIOVASCULAR DEVICES Cardiovascular Diagnostic Devices § 870.1240 Flow-directed catheter...

21 CFR 870.1240 - Flow-directed catheter.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Flow-directed catheter. 870.1240 Section 870.1240 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES CARDIOVASCULAR DEVICES Cardiovascular Diagnostic Devices § 870.1240 Flow-directed catheter...

High energy density redox flow device

DOEpatents

Chiang, Yet-Ming; Carter, W. Craig; Ho, Bryan Y; Duduta, Mihai; Limthongkul, Pimpa

2014-05-13

Redox flow devices are described in which at least one of the positive electrode or negative electrode-active materials is a semi-solid or is a condensed ion-storing electroactive material, and in which at least one of the electrode-active materials is transported to and from an assembly at which the electrochemical reaction occurs, producing electrical energy. The electronic conductivity of the semi-solid is increased by the addition of conductive particles to suspensions and/or via the surface modification of the solid in semi-solids (e.g., by coating the solid with a more electron conductive coating material to increase the power of the device). High energy density and high power redox flow devices are disclosed. The redox flow devices described herein can also include one or more inventive design features. In addition, inventive chemistries for use in redox flow devices are also described.

Internal Flow

NASA Astrophysics Data System (ADS)

Greitzer, E. M.; Tan, C. S.; Graf, M. B.

2004-06-01

Focusing on phenomena important in implementing the performance of a broad range of fluid devices, this work describes the behavior of internal flows encountered in propulsion systems, fluid machinery (compressors, turbines, and pumps) and ducts (diffusers, nozzles and combustion chambers). The book equips students and practicing engineers with a range of new analytical tools. These tools offer enhanced interpretation and application of both experimental measurements and the computational procedures that characterize modern fluids engineering.

Mobile platform for overhead detectors of road vehicles.

DOT National Transportation Integrated Search

2002-06-01

The California Department of Transportation (CALTRANS) has a need to monitor traffic flow over freeways. Currently, this is done mainly : through the use of loop detectors. These are measuring devices that are buried under the road pavement, an...

Microfluidics for simultaneous quantification of platelet adhesion and blood viscosity

PubMed Central

Yeom, Eunseop; Park, Jun Hong; Kang, Yang Jun; Lee, Sang Joon

2016-01-01

Platelet functions, including adhesion, activation, and aggregation have an influence on thrombosis and the progression of atherosclerosis. In the present study, a new microfluidic-based method is proposed to estimate platelet adhesion and blood viscosity simultaneously. Blood sample flows into an H-shaped microfluidic device with a peristaltic pump. Since platelet aggregation may be initiated by the compression of rotors inside the peristaltic pump, platelet aggregates may adhere to the H-shaped channel. Through correlation mapping, which visualizes decorrelation of the streaming blood flow, the area of adhered platelets (APlatelet) can be estimated without labeling platelets. The platelet function is estimated by determining the representative index IA·T based on APlatelet and contact time. Blood viscosity is measured by monitoring the flow conditions in the one side channel of the H-shaped device. Based on the relation between interfacial width (W) and pressure ratio of sample flows to the reference, blood sample viscosity (μ) can be estimated by measuring W. Biophysical parameters (IA·T, μ) are compared for normal and diabetic rats using an ex vivo extracorporeal model. This microfluidic-based method can be used for evaluating variations in the platelet adhesion and blood viscosity of animal models with cardiovascular diseases under ex vivo conditions. PMID:27118101

Observation and experimental investigation of confinement effects on ion transport and electrokinetic flows at the microscale

PubMed Central

Benneker, Anne M.; Wood, Jeffery A.; Tsai, Peichun A.; Lammertink, Rob G. H.

2016-01-01

Electrokinetic effects adjacent to charge-selective interfaces (CSI) have been experimentally investigated in microfluidic platforms in order to gain understanding on underlying phenomena of ion transport at elevated applied voltages. We experimentally investigate the influence of geometry and multiple array densities of the CSI on concentration and flow profiles in a microfluidic set-up using nanochannels as the CSI. Particle tracking obtained under chronoamperometric measurements show the development of vortices in the microchannel adjacent to the nanochannels. We found that the direction of the electric field and the potential drop inside the microchannel has a large influence on the ion transport through the interface, for example by inducing immediate wall electroosmotic flow. In microfluidic devices, the electric field may not be directed normal to the interface, which can result in an inefficient use of the CSI. Multiple vortices are observed adjacent to the CSI, growing in size and velocity as a function of time and dependent on their location in the microfluidic device. Local velocities inside the vortices are measured to be more than 1.5 mm/s. Vortex speed, as well as flow speed in the channel, are dependent on the geometry of the CSI and the distance from the electrode. PMID:27853257

Dual chronoamperometric detection of enzymatic biomarkers using magnetic beads and a low-cost flow cell.

PubMed

Moral-Vico, Javier; Barallat, Jaume; Abad, Llibertat; Olivé-Monllau, Rosa; Muñoz-Pascual, Francesc Xavier; Galán Ortega, Amparo; del Campo, F Javier; Baldrich, Eva

2015-07-15

In this work we report on the production of a low cost microfluidic device for the multiplexed electrochemical detection of magneto bioassays. As a proof of concept, the device has been used to detect myeloperoxidase (MPO), a cardiovascular biomarker. With this purpose, two bioassays have been optimized in parallel onto magnetic beads (MBs) for the simultaneous detection of MPO endogenous peroxidase activity and quantification of total MPO. Since the two bioassays produced signals of different magnitude for each concentration of MPO tested, two detection strategies have been compared, which entailed registering steady state currents (Iss) under substrate flow, and measuring the peak currents (Ip) produced in a stopped flow approach. As it will be shown, appropriate tuning of the detection and flow conditions can provide extremely sensitive detection, but also allow simultaneous detection of assays or parameters that would produce signals of different orders of magnitude when measured by a single detection strategy. In order to demonstrate the feasibility of the detection strategy reported, a dual MPO mass and activity assay has been finally applied to the study of 10 real plasma samples, allowing patient classification according to the risk of suffering a cardiovascular event. Copyright © 2015 Elsevier B.V. All rights reserved.

Application of acoustic doppler velocimeters for streamflow measurements

USGS Publications Warehouse

Rehmel, M.

2007-01-01

The U.S. Geological Survey (USGS) principally has used Price AA and Price pygmy mechanical current meters for measurement of discharge. New technologies have resulted in the introduction of alternatives to the Price meters. One alternative, the FlowTracker acoustic Doppler velocimeter, was designed by SonTek/YSI to make streamflow measurements in wadeable conditions. The device measures a point velocity and can be used with standard midsection method algorithms to compute streamflow. The USGS collected 55 quality-assurance measurements with the FlowTracker at 43 different USGS streamflow-gaging stations across the United States, with mean depths from 0.05to0.67m, mean velocities from 13 to 60 cm/s, and discharges from 0.02 to 12.4m3/s. These measurements were compared with Price mechanical current meter measurements. Analysis of the comparisons shows that the FlowTracker discharges were not statistically different from the Price meter discharges at a 95% confidence level. ?? 2007 ASCE.

Cooling molten salt reactors using "gas-lift"

NASA Astrophysics Data System (ADS)

Zitek, Pavel; Valenta, Vaclav; Klimko, Marek

2014-08-01

This study briefly describes the selection of a type of two-phase flow, suitable for intensifying the natural flow of nuclear reactors with liquid fuel - cooling mixture molten salts and the description of a "Two-phase flow demonstrator" (TFD) used for experimental study of the "gas-lift" system and its influence on the support of natural convection. The measuring device and the application of the TDF device is described. The work serves as a model system for "gas-lift" (replacing the classic pump in the primary circuit) for high temperature MSR planned for hydrogen production. An experimental facility was proposed on the basis of which is currently being built an experimental loop containing the generator, separator bubbles and necessary accessories. This loop will model the removal of gaseous fission products and tritium. The cleaning of the fuel mixture of fluoride salts eliminates problems from Xenon poisoning in classical reactors.

Value contamination avoidance devices

NASA Technical Reports Server (NTRS)

Endicott, D. L.

1975-01-01

Mechanical redesign methods were used to minimize contamination damage of conventional fluid components and a contamination separator device was developed for long term reusable space vehicles. These were incorporated into an existing 50.8 mm poppet valve and tested for damage tolerance in a full size open loop flow system with gaseous and liquid nitrogen. Cyclic and steady flow conditions were tested with particles of 125 to 420 micrometers aluminum oxide dispersed in the test fluids. Nonflow life tests (100,000 cycles) were made with two valve configurations in gaseous hydrogen. The redesigned valve had an acceptable cycle life and improved tolerance to contamination damage when the primary sealing surfaces were coated with thin coatings of hard plastic (Teflon S and Kynar). Analytical studies and flow testing were completed of four different versions of the separator. overall separation efficiencies in the 55-90% range were measured with these non-optimum configurations.

A NEW PRINCIPLE FOR ELECTROMAGNETIC CATHETER FLOW METERS*

PubMed Central

Kolin, Alexander

1969-01-01

An electromagnetic catheter flow meter is described in which the magnetic field is generated by two parallel bundles of wire carrying equal currents in opposite directions. The electrodes are fixed centrally to the insulated wire bundles that generate the magnetic field. The flow sensor is flexible, resembling a split catheter. The flow transducer is designed to constrict as it is introduced through a branch artery and to expand in the main artery over the span of its diameter. The principle is suitable for branch flow measurement as well as for measurement of flow in a major artery or vein by the same transducer. A special method of guiding the electrode wires results in a zero base line at zero flow for the entire range of diameters accommodating the field generating coil. The electrodes could be used in this configuration with a magnetic field generated by coils external to the patient for blood flow measurements with a catheter of reduced gauge. The transducer can be made smaller in circumference than those employed in other electromagnetic flow measuring catheter devices. This feature is of special value for envisaged clinical uses (percutaneous introduction) to minimize surgical intervention. The velocity sensitivity of the flow transducer is a logarithmic function of the tube diameter. The flow throughout the entire tube cross section contributes to the flow signal. It is sufficient to calibrate the transducer by one measurement in a dielectric conduit of less than maximum diameter. The sensitivity at other diameters follows from a logarithmic plot. The diameter of the blood vessel is outlined by the transducer in radiograms, thus obviating the need for radiopaque materials. The principle was demonstrated by measurements in vitro. Experiments in vivo, derivation of equations, and construction details will be published elsewhere. Images PMID:5257127

40 CFR Table 3 to Subpart Mmm of... - Monitoring Requirements for Control Devices a

Code of Federal Regulations, 2012 CFR

2012-07-01

.... Carbon adsorber (regenerative) Stream flow monitoring device, and 1. Total regeneration stream mass or volumetric flow during carbon bed regeneration cycle(s) 1. For each regeneration cycle, record the total regeneration stream mass or volumetric flow. Carbon bed temperature monitoring device 2. Temperature of carbon...

40 CFR Table 3 to Subpart Mmm of... - Monitoring Requirements for Control Devices a

Code of Federal Regulations, 2011 CFR

2011-07-01

.... Carbon adsorber (regenerative) Stream flow monitoring device, and 1. Total regeneration stream mass or volumetric flow during carbon bed regeneration cycle(s) 1. For each regeneration cycle, record the total regeneration stream mass or volumetric flow. Carbon bed temperature monitoring device 2. Temperature of carbon...

40 CFR Table 3 to Subpart Mmm of... - Monitoring Requirements for Control Devices a

Code of Federal Regulations, 2010 CFR

2010-07-01

.... Carbon adsorber (regenerative) Stream flow monitoring device, and 1. Total regeneration stream mass or volumetric flow during carbon bed regeneration cycle(s) 1. For each regeneration cycle, record the total regeneration stream mass or volumetric flow. Carbon bed temperature monitoring device 2. Temperature of carbon...

Deployable Emergency Shutoff Device Blocks High-Velocity Fluid Flows

NASA Technical Reports Server (NTRS)

Nabors, Sammy A.

2015-01-01

NASA's Marshall Space Flight Center has developed a device and method for blocking the flow of fluid from an open pipe. Motivated by the sea-bed oil-drilling catastrophe in the Gulf of Mexico in 2010, NASA innovators designed the device to plug, control, and meter the flow of gases and liquids. Anchored with friction fittings, spikes, or explosively activated fasteners, the device is well-suited for harsh environments and high fluid velocities and pressures. With the addition of instrumentation, it can also be used as a variable area flow metering valve that can be set based upon flow conditions. With robotic additions, this patent-pending innovation can be configured to crawl into a pipe then anchor and activate itself to block or control fluid flow.

[Current status of the development of wireless sensors for medical applications].

PubMed

Moor, C; Braecklein, M; Jörns, N

2005-01-01

Wireless near-field transmission has been a challenge for scientists developing medical sensors for a long time. Here, instruments which measure a patient's ECG, oxygen saturation, blood pressure, peak flow, weight, blood glucose etc. are to be equipped with suitable transmission technology. Application scenarios for these sensors can be found in all medical areas where cable connections are irritating for the doctor, patient and other care personnel. This problem is especially common in sport medicine, sleep medicine, emergency medicine and intensive care. Based on its beneficial properties with regard to power consumption, range, data security and network capability, the worldwide standard radio technology Bluetooth was selected to transmit measurements. Since digital data is sent to a receiving station via Bluetooth, the measurement pre-processing now takes place in the patient sensor itself, instead of being processed by the monitor. In this article, a Bluetooth ECG, Bluetooth pulse oximeter, Bluetooth peak flow meter and Bluetooth event recorder will be introduced. On the one hand, systems can be realized with these devices, which allow patients to be monitored online (ECG, pulse oximeter). These devices can also be integrated in disease management programs (peak flow meter) and can be used to monitor high-risk patients in their home environment (event recorder).

Waves and Instabilities in Steady-State High-Beta Plasmas

DTIC Science & Technology

1976-07-01

us working on magnetospheric related problems. Several groups are now constructing identical devices including Y. Nishida of Utsunomiya University...and other satellites operate in the magnetospheric plasma environment at the geosynchronous orbit (%6.6 earth radii). Arc- related deterioration of the...carefully 16 - 3diagnosed device produces a plasma of density n 3 x 10 cm and temperature Te = Ti W 1.6eV. (3) Heat Flow Measurements in a Laser-Heated

Inducer Hydrodynamic Load Measurement Devices

NASA Technical Reports Server (NTRS)

Skelley, Stephen E.; Zoladz, Thomas F.

2002-01-01

Marshall Space Flight Center (MSFC) has demonstrated two measurement devices for sensing and resolving the hydrodynamic loads on fluid machinery. The first - a derivative of the six component wind tunnel balance - senses the forces and moments on the rotating device through a weakened shaft section instrumented with a series of strain gauges. This "rotating balance" was designed to directly measure the steady and unsteady hydrodynamic loads on an inducer, thereby defining both the amplitude and frequency content associated with operating in various cavitation modes. The second device - a high frequency response pressure transducer surface mounted on a rotating component - was merely an extension of existing technology for application in water. MSFC has recently completed experimental evaluations of both the rotating balance and surface-mount transducers in a water test loop. The measurement bandwidth of the rotating balance was severely limited by the relative flexibility of the device itself, resulting in an unexpectedly low structural bending mode and invalidating the higher frequency response data. Despite these limitations, measurements confirmed that the integrated loads on the four-bladed inducer respond to both cavitation intensity and cavitation phenomena. Likewise, the surface-mount pressure transducers were subjected to a range of temperatures and flow conditions in a non-rotating environment to record bias shifts and transfer functions between the transducers and a reference device. The pressure transducer static performance was within manufacturer's specifications and dynamic response accurately followed that of the reference.

Inducer Hydrodynamic Load Measurement Devices

NASA Technical Reports Server (NTRS)

Skelley, Stephen E.; Zoladz, Thomas F.; Turner, Jim (Technical Monitor)

2002-01-01

Marshall Space Flight Center (MSFC) has demonstrated two measurement devices for sensing and resolving the hydrodynamic loads on fluid machinery. The first - a derivative of the six-component wind tunnel balance - senses the forces and moments on the rotating device through a weakened shaft section instrumented with a series of strain gauges. This rotating balance was designed to directly measure the steady and unsteady hydrodynamic loads on an inducer, thereby defining both the amplitude and frequency content associated with operating in various cavitation modes. The second device - a high frequency response pressure transducer surface mounted on a rotating component - was merely an extension of existing technology for application in water. MSFC has recently completed experimental evaluations of both the rotating balance and surface-mount transducers in a water test loop. The measurement bandwidth of the rotating balance was severely limited by the relative flexibility of the device itself, resulting in an unexpectedly low structural bending mode and invalidating the higher-frequency response data. Despite these limitations, measurements confirmed that the integrated loads on the four-bladed inducer respond to both cavitation intensity and cavitation phenomena. Likewise, the surface-mount pressure transducers were subjected to a range of temperatures and flow conditions in a non-rotating environment to record bias shifts and transfer functions between the transducers and a reference device. The pressure transducer static performance was within manufacturer's specifications and dynamic response accurately followed that of the reference.

Implantable physiologic controller for left ventricular assist devices with telemetry capability.

PubMed

Asgari, Siavash S; Bonde, Pramod

2014-01-01

Rotary type left ventricular assist devices have mitigated the problem of durability associated with earlier pulsatile pumps and demonstrated improved survival. However, the compromise is the loss of pulsatility due to continuous flow and retained percutaneous driveline leading to increased mortality and morbidity. Lack of pulsatility is implicated in increased gastrointestinal bleeding, aortic incompetence, and diastolic hypertension. We present a novel, wirelessly powered, ultra-compact, implantable physiologic controller capable of running a left ventricular assist device in a pulsatile mode with wireless power delivery. The schematic of our system was laid out on a circuit board to wirelessly receive power and run a left ventricular assist device with required safety and backup measures. We have embedded an antenna and wireless network for telemetry. Multiple signal processing steps and controlling algorithm were incorporated. The controller was tested in in vitro and in vivo experiments. The controller drove left ventricular assist devices continuously for 2 weeks in an in vitro setup and in vivo without any failure. Our controller is more power efficient than the current Food and Drug Administration-approved left ventricular assist device controllers. When used with electrocardiography synchronization, the controller allowed on-demand customization of operation with instantaneous flow and revolutions per minute changes, resulting in a pulsatile flow with adjustable pulse pressure. Our test results prove the system to be remarkably safe, accurate, and efficient. The unique combination of wireless powering and small footprint makes this system an ideal totally implantable physiologic left ventricular assist device system. Copyright © 2014 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.

A comparison of measured and predicted test flow in an expansion tube with air and oxygen test gases

NASA Technical Reports Server (NTRS)

Aaggard, K. V.; Goad, W. K.

1975-01-01

Simultaneous time-resolved measurements of temperature, density, pitot pressure, and wall pressure in both air and O2 test gases were obtained in the Langley pilot model expansion tube. These tests show nonequilibrium chemical and vibrational relaxation significantly affect the test-flow condition. The use of an electromagnetic device to preopen the secondary diaphragm before the arrival of the primary shock wave resulted in an improvement in the agreement between the measured pitot pressure and the value inferred from measured density and interface velocity. Boundary-layer splitter plates used to reduce the wall boundary layer show that this disagreement in the measured and inferred pitot pressures is not a result of boundary-layer effects.

Thermoelectric Air/Soil Energy-Harvesting Device

NASA Technical Reports Server (NTRS)

Snyder, Jeffrey; Fleurial, Jean-Pierre; Lawrence, Eric

2005-01-01

A proposed thermoelectric device would exploit natural temperature differences between air and soil to harvest small amounts of electric energy. Because the air/soil temperature difference fluctuates between nighttime and daytime, it is almost never zero, and so there is almost always some energy available for harvesting. Unlike photovoltaic cells, the proposed device could operate in the absence of sunlight. Unlike a Stirling engine, which could be designed to extract energy from the air/soil temperature difference, the proposed device would contain no moving parts. The main attractive feature of the proposed device would be high reliability. In a typical application, this device would be used for low-power charging of a battery that would, in turn, supply high power at brief, infrequent intervals for operating an instrumentation package containing sensors and communication circuits. The device (see figure) would include a heat exchanger buried in soil and connected to a heat pipe extending up to a short distance above the ground surface. A thermoelectric microgenerator (TEMG) would be mounted on top of the heat pipe. The TEMG could be of an advanced type, now under development, that could maintain high (relative to prior thermoelectric generators) power densities at small temperature differentials. A heat exchanger exposed to the air would be mounted on top of the TEMG. It would not matter whether the air was warmer than the soil or the soil warmer than the air: as long as there was a nonzero temperature difference, heat would flow through the device and electricity would be generated. A study of factors that could affect the design and operation of the device has been performed. These factors include the thermal conductances of the soil, the components of the device, the contacts between the components of the device, and the interfaces between the heat exchangers and their environments. The study included experiments that were performed on a model of the device to demonstrate feasibility. Because a TEMG suitable for this device was not available, a brass dummy component having a known thermal conductance of 1.68 W/K was substituted for the TEMG in the models to enable measurement of heat flows. The model included a water-based heat pipe 30 in. (76.2 cm) long and 1 in. (2.54 cm) in diameter, wrapped with polyethylene insulation to reduce radial heat flow. Several different side heat exchangers were tested. On the basis of the measurements, it was predicted that if a prototype of the device were equipped with a TEMG, daily temperature fluctuations would cause its output power to fluctuate between 0 and about 0.1 mW, peaking to 0.35 mW during early afternoon.

Cavitation Inception in Separated Flows.

DTIC Science & Technology

1981-12-01

measured data. Keller (1972, 1973) determined the nuclei population by using a single particle light scattering device (the sample volume was... computations of the average pressure coefficient. The amount of air dissolved in the water varied from 10 to 11 ppm ( molar ) and was measured with a Van Slyke...fluctuating pressures were also measured. .-The conditions for cavitation inception and desinence were determined and several holograms were recorded

Reynolds number scaling of the influence of boundary layers on the global behavior of laboratory quasi-Keplerian flows

DOE Office of Scientific and Technical Information (OSTI.GOV)

Edlund, E. M.; Ji, H.

2015-10-06

Here, we present fluid velocity measurements in a modified Taylor-Couette device operated in the quasi-Keplerian regime, where it is observed that nearly ideal flows exhibit self-similarity under scaling of the Reynolds number. In contrast, nonideal flows show progressive departure from ideal Couette as the Reynolds number is increased. We present a model that describes the observed departures from ideal Couette rotation as a function of the fluxes of angular momentum across the boundaries, capturing the dependence on Reynolds number and boundary conditions.

Reynolds number scaling of the influence of boundary layers on the global behavior of laboratory quasi-Keplerian flows.

PubMed

Edlund, E M; Ji, H

2015-10-01

We present fluid velocity measurements in a modified Taylor-Couette device operated in the quasi-Keplerian regime, where it is observed that nearly ideal flows exhibit self-similarity under scaling of the Reynolds number. In contrast, nonideal flows show progressive departure from ideal Couette as the Reynolds number is increased. We present a model that describes the observed departures from ideal Couette rotation as a function of the fluxes of angular momentum across the boundaries, capturing the dependence on Reynolds number and boundary conditions.

The portable device for continual measurement of radon progenies on filter using the detector Timepix.

PubMed

Bulanek, Boris; Hulka, Jiri; Jilek, Karel; Stekl, Ivan

2015-06-01

In this article, a portable device was presented for continual measuring of equilibrium equivalent concentration (EEC) of (222)Rn based on the Timepix detector with 300-µm-thick active layer. In order to have a portable device, a filtration head was developed for collecting short-lived radon progenies attached on aerosols. The short-lived progenies are estimated from analysing alphas from decay of (218,214)Po from Millipore filter after termination of filtration. Comparison with beta measurement was done as well. The dependence of EEC on an air flow and filtration time was studied. The low-level detection limit for EEC was estimated from the last 10 min of 3-h decay measurement and was found in the range of 40-70 Bq m(-3). EEC was measured in National Radiation Protection Institute radon chamber, and results were compared with the commercial detector Fritra4. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Devices and methods of operation thereof for providing stable flow for centrifugal compressors

NASA Technical Reports Server (NTRS)

Skoch, Gary J. (Inventor); Stevens, Mark A. (Inventor); Jett, Thomas A. (Inventor)

2008-01-01

Centrifugal compressor flow stabilizing devices and methods of operation thereof are disclosed that act upon the flow field discharging from the impeller of a centrifugal compressor and modify the flow field ahead of the diffuser vanes such that flow conditions contributing to rotating stall and surge are reduced or even eliminated. In some embodiments, shaped rods and methods of operation thereof are disclosed, whereas in other embodiments reverse-tangent air injection devices and methods are disclosed.

Comparison of Respiratory Resistance Measurements Made with an Airflow Perturbation Device with Those from Impulse Oscillometry

PubMed Central

Pan, J.; Saltos, A.; Smith, D.; Johnson, A.; Vossoughi, J.

2013-01-01

The airflow perturbation device (APD) has been developed as a portable, easy to use, and a rapid response instrument for measuring respiratory resistance in humans. However, the APD has limited data validating it against the established techniques. This study used a mechanical system to simulate the normal range of human breathing to validate the APD with the clinically accepted impulse oscillometry (IOS) technique. The validation system consisted of a sinusoidal flow generator with ten standardized resistance configurations that were shown to represent a total range of resistances from 0.12 to 0.95 kPa·L−1 ·s (1.2–9.7 cm H2O·L−1 ·s). Impulse oscillometry measurements and APD measurements of the mechanical system were recorded and compared at a constant airflow of 0.15 L·s−1. Both the IOS and APD measurments were accurate in assessing nominal resistance. In addition, a strong linear relationship was observed between APD measurements and IOS measurements (R 2 = 0.999). A second series of measurements was made on ten human volunteers with external resistors added in their respiratory flow paths. Once calibrated with the mechanical system, the APD gave respiratory resistance measurements within 5% of IOS measurements. Because of their comparability to IOS measurements, APD measurements are shown to be valid representations of respiratory resistance. PMID:27006908

The influence of device position on the flow within the Penn State 12 cc pediatric ventricular assist device.

PubMed

Schönberger, Markus; Deutsch, Steven; Manning, Keefe B

2012-01-01

Ventricular assist devices are a commonly used heart failure therapy for adult patients as bridge-to-transplant or bridge-to-recovery tools. The application of adult ventricular assist devices in pediatric patients has led to increased thrombotic events. Therefore, we have been developing a pediatric ventricular assist device (PVAD), the Penn State 12 cc PVAD. It is designed for patients with a body weight of 5-15 kg and has a stroke volume of 12 cc. Clot formation is the major concern. It is correlated to the coagulability of blood, the blood contacting materials and the fluid dynamics within the system. The intent is for the PVAD to be a long term therapy. Therefore, the system may be oriented in different positions according to the patient's behavior. This study evaluates for the first time the impact of position on the flow patterns within the Penn State 12 cc PVAD, which may help to improve the PVAD design concerning chamber and ports geometries. The fluid dynamics are visualized by particle image velocimetry. The evaluation is based on inlet jet behavior and calculated wall shear rates. Vertical and horizontal model orientations are compared, both with a beat rate of 75, outlet pressures of 90/60 mm Hg and a flow rate of 1.3 l/min. The results show a significant change of the inlet jet behavior and the development of a rotational flow pattern. Vertically, the inlet jet is strong along the wall. It initiates a rotational flow pattern with a wandering axis of rotation. In contrast, the horizontal model orientation results show a weaker inlet jet along the wall with a nearly constant center of rotation location, which can be correlated to a higher risk of thrombotic events. In addition, high speed videography illustrates differences in the diaphragm motion during diastole. Diaphragm opening trajectories measurements determine no significant impact of the density of the blood analog fluids. Hence, the results correlate to human blood.

40 CFR 63.7927 - What are my inspection and monitoring requirements for closed vent systems and control devices?

Code of Federal Regulations, 2011 CFR

2011-07-01

... (CPMS) to measure and record the hourly average total regeneration stream mass flow during each carbon... during regeneration (except during the cooling cycle). (3) Use a CPMS to measure and record the hourly average temperature of the adsorption bed after regeneration (and within 15 minutes after completing any...

40 CFR 63.7927 - What are my inspection and monitoring requirements for closed vent systems and control devices?

Code of Federal Regulations, 2013 CFR

2013-07-01

... (CPMS) to measure and record the hourly average total regeneration stream mass flow during each carbon... during regeneration (except during the cooling cycle). (3) Use a CPMS to measure and record the hourly average temperature of the adsorption bed after regeneration (and within 15 minutes after completing any...

40 CFR 63.7927 - What are my inspection and monitoring requirements for closed vent systems and control devices?

Code of Federal Regulations, 2012 CFR

2012-07-01

... (CPMS) to measure and record the hourly average total regeneration stream mass flow during each carbon... during regeneration (except during the cooling cycle). (3) Use a CPMS to measure and record the hourly average temperature of the adsorption bed after regeneration (and within 15 minutes after completing any...

40 CFR 63.7927 - What are my inspection and monitoring requirements for closed vent systems and control devices?

Code of Federal Regulations, 2014 CFR

2014-07-01

... (CPMS) to measure and record the hourly average total regeneration stream mass flow during each carbon... during regeneration (except during the cooling cycle). (3) Use a CPMS to measure and record the hourly average temperature of the adsorption bed after regeneration (and within 15 minutes after completing any...

40 CFR 63.7927 - What are my inspection and monitoring requirements for closed vent systems and control devices?

Code of Federal Regulations, 2010 CFR

2010-07-01

... (CPMS) to measure and record the hourly average total regeneration stream mass flow during each carbon... during regeneration (except during the cooling cycle). (3) Use a CPMS to measure and record the hourly average temperature of the adsorption bed after regeneration (and within 15 minutes after completing any...

Method and apparatus for elemental and isotope measurements and diagnostics-microwave induced plasma-cavity ring-down spectroscopy

DOEpatents

Wang, Chuji; Winstead, Christopher; Duan, Yixiang

2006-05-30

Provided is a novel system for conducting elemental measurements using cavity ring-down spectroscopy (CRDS). The present invention provides sensitivity thousands of times improved over conventional devices and does so with the advantages of low power, low plasma flow rate, and the ability being sustained with various gases.

An automated cell analysis sensing system based on a microfabricated rheoscope for the study of red blood cells physiology.

PubMed

Bransky, Avishay; Korin, Natanel; Nemirovski, Yael; Dinnar, Uri

2006-08-15

An automated rheoscope has been developed, utilizing a microfabricated glass flow cell, high speed camera and advanced image-processing software. RBCs suspended in a high viscosity medium were filmed flowing through a microchannel. Under these conditions, RBCs exhibit different orientations and deformations according to their location in the velocity profile. The rheoscope system produces valuable data such as velocity profile of RBCs, spatial distribution within a microchannel and deformation index (DI) curves. The variation of DI across the channel height, due to change in shear stress, was measured carrying implications for diffractometry methods. These curves of DI were taken at a constant flow rate and cover most of the relevant shear stress spectrum. This is an improvement of the existing techniques for deformability measurements and may serve as a diagnostic tool for certain blood disorders. The DI curves were compared to measurements of the flowing RBCs velocity profile. In addition, we found that RBCs flowing in a microchannel are mostly gathered in the center of the flow and maintain a characteristic spatial distribution. The spatial distribution in this region changes slightly with increasing flow rate. Hence, the system described, provides means for examining the behavior of individual RBCs, and may serve as a microfabricated diagnostic device for deformability measurement.

The effects of sampling location and turbulence on discharge estimates in short converging turbine intakes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Romero-Gomez, P.; Harding, S. F.; Richmond, M. C.

2017-01-01

Standards provide recommendations for best practices when installing current meters to measure fluid flow in closed conduits. A central guideline requires the velocity distribution to be regular and the flow steady. Because of the nature of the short converging intakes typical of low-head hydroturbines, these assumptions may be invalid if current meters are intended to be used to estimate discharge. Usual concerns are (1) the effects of the number of devices, (2) the sampling location and (3) the high turbulence caused by blockage from submersible traveling screens usually deployed for safe downstream fish passage. These three effects were examined inmore » the present study by using 3D simulated flow fields in both steady-state and transient modes. In the process of describing an application at an existing hydroturbine intake at Ice Harbor Dam, the present work outlined the methods involved, which combined computational fluid dynamics, laboratory measurements in physical models of the hydroturbine, and current meter performance evaluations in experimental settings. The main conclusions in this specific application were that a steady-state flow field sufficed to determine the adequate number of meters and their location, and that both the transverse velocity and turbulence intensity had a small impact on estimate errors. However, while it may not be possible to extrapolate these findings to other field conditions and measuring devices, the study laid out a path to conduct similar assessments in other applications.« less

Simulation of leakage current measurement on medical devices using helmholtz coil configuration with different current flow

NASA Astrophysics Data System (ADS)

Sutanto, E.; Chandra, F.; Dinata, R.

2017-05-01

Leakage current measurement which can follow IEC standard for medical device is one of many challenges to be answered. The IEC 60601-1 has defined that the limit for a leakage current for Medical Device can be as low as 10 µA and as high as 500 µA, depending on which type of contact (applied part) connected to the patient. Most people are using ELCB (Earth-leakage circuit breaker) for safety purpose as this is the most common and available safety device in market. One type of ELCB devices is RCD (Residual Current Device) and this RCD type can measure the leakage current directly. This work will show the possibility on how Helmholtz Coil Configuration can be made to be like the RCD. The possibility is explored by comparing the magnetic field formula from each device, then it proceeds with a simulation using software EJS (Easy Java Simulation). The simulation will make sure the concept of magnetic field current cancellation follows the RCD concept. Finally, the possibility of increasing the measurement’s sensitivity is also analyzed. The sensitivity is needed to see the possibility on reaching the minimum leakage current limit defined by IEC, 0.01mA.

Evaluating sediment capture rates for different sediment basin designs.

DOT National Transportation Integrated Search

2007-08-01

The effectiveness of sediment control devices was studied on a large NC DOT project to determine the : effects of different designs and conditions. Flow and sediment content of water exiting six different traps : and basins were measured and the amou...

An easy way to measure accurately the direct magnetoelectric voltage coefficient of thin film devices

NASA Astrophysics Data System (ADS)

Poullain, Gilles; More-Chevalier, Joris; Cibert, Christophe; Bouregba, Rachid

2017-01-01

TbxDy1-xFe2/Pt/Pb(Zrx, Ti1-x)O3 thin films were grown on Pt/TiO2/SiO2/Si substrate by multi-target sputtering. The magnetoelectric voltage coefficient αΗΜΕ was determined at room temperature using a lock-in amplifier. By adding, in series in the circuit, a capacitor of the same value as that of the device under test, we were able to demonstrate that the magnetoelectric device behaves as a voltage source. Furthermore, a simple way to subtract the stray voltage arising from the flow of eddy currents in the measurement set-up, is proposed. This allows the easy and accurate determination of the true magnetoelectric voltage coefficient. A large αΗΜΕ of 8.3 V/cm. Oe was thus obtained for a Terfenol-D/Pt/PZT thin film device, without DC magnetic field nor mechanical resonance.

Debris flow impact estimation on a rigid barrier

NASA Astrophysics Data System (ADS)

Vagnon, Federico; Segalini, Andrea

2016-07-01

The aim of this paper is to analyse debris flow impact against rigid and undrained barrier in order to propose a new formulation for the estimation of acting force after the flow impact to safe design protection structures. For this reason, this work concentrates on the flow impact, by performing a series of small scale tests in a specifically created flume. Flow characteristics (flow height and velocity) and applied loads (dynamic and static) on barrier were measured using four ultrasonic devices, four load cells and a contact surface pressure gauge. The results obtained were compared with main existing models and a new equation is proposed. Furthermore, a brief review of the small scale theory was provided to analyse the scale effects that can affect the results.

An experimental facility for the visual study of turbulent flows.

NASA Technical Reports Server (NTRS)

Brodkey, R. S.; Hershey, H. C.; Corino, E. R.

1971-01-01

An experimental technique which allows visual observations of the wall area in turbulent pipe flow is described in detail. It requires neither the introduction of any injection or measuring device into the flow nor the presence of a two-phase flow or of a non-Newtonian fluid. The technique involves suspending solid MgO particles of colloidal size in trichloroethylene and photographing their motions near the wall with a high speed movie camera moving with the flow. Trichloroethylene was chosen in order to eliminate the index of refraction problem in a curved wall. Evaluation of the technique including a discussion of limitations is included. Also the technique is compared with previous methods of visual observations of turbulent flow.

Monitoring patients with continuous-flow ventricular assist devices outside of the intensive care unit: novel challenges to bedside nursing.

PubMed

O'Shea, Genevieve; Teuteberg, Jeffrey J; Severyn, Donald A

2013-03-01

Ventricular assist devices provide therapeutic options for patients with severe heart failure who have exhausted available medical therapies. With restoration of organ perfusion with ventricular assist devices, the heart failure resolves and quality of life and functional status improve. The current generation of continuous-flow devices present novel challenges to the clinical assessment of patients by substantially reducing or nearly eliminating any palpable pulse. Patients therefore generally have inadequate arterial pulsatility for most noninvasive monitoring devices such as pulse oximeters or automated blood pressure cuffs to work accurately. This article describes the function of continuous-flow devices and how this function affects common monitoring options, as well as how to clinically assess recipients of continuous-flow devices to promptly identify those whose condition may be deteriorating or who may be receiving inadequate perfusion.

Ejector Enhanced Pulsejet Based Pressure Gain Combustors: An Old Idea With a New Twist

NASA Technical Reports Server (NTRS)

Paxson, Daniel E.; Dougherty, Kevin T.

2005-01-01

An experimental investigation of pressure-gain combustion for gas turbine application is described. The test article consists of an off-the-shelf valved pulsejet, and an optimized ejector, both housed within a shroud. The combination forms an effective can combustor across which there is a modest total pressure rise rather than the usual loss found in conventional combustors. Although the concept of using a pulsejet to affect semi-constant volume (i.e., pressure-gain) combustion is not new, that of combining it with a well designed ejector to efficiently mix the bypass flow is. The result is a device which to date has demonstrated an overall pressure rise of approximately 3.5 percent at an overall temperature ratio commensurate with modern gas turbines. This pressure ratio is substantially higher than what has been previously reported in pulsejet-based combustion experiments. Flow non-uniformities in the downstream portion of the device are also shown to be substantially reduced compared to those within the pulsejet itself. The standard deviation of total pressure fluctuations, measured just downstream of the ejector was only 5.0 percent of the mean. This smoothing aspect of the device is critical to turbomachinery applications since turbine performance is, in general, negatively affected by flow non-uniformities and unsteadiness. The experimental rig will be described and details of the performance measurements will be presented. Analyses showing the thermodynamic benefits from this level of pressure-gain performance in a gas turbine will also be assessed for several engine types. Issues regarding practical development of such a device are discussed, as are potential emissions reductions resulting from the rich burning nature of the pulsejet and the rapid mixing (quenching) associated with unsteady ejectors.

Control of low-speed turbulent separated flow over a backward-facing ramp. Ph.D. Thesis - Old Dominion Univ.

NASA Technical Reports Server (NTRS)

Lin, John C.

1992-01-01

The relative performance and flow phenomena associated with several devices for controlling turbulent separated flow were investigated at low speeds. Relative performance of the devices was examined for flow over a curved, backward-facing ramp in a wind tunnel, and the flow phenomena were examined in a water tunnel using dye-flow visualization. Surface static pressure measurements and oil-flow visualization results from the wind tunnel tests indicated that transverse grooves, longitudinal grooves, submerged vortex generators, vortex generator jets (VGJ's), Viets' fluidic flappers, elongated arches at positive angle of attack, and large-eddy breakup devices (LEBU's) at positive angle of attack placed near the baseline separation location reduce flow separation and increase pressure recovery. Spanwise cylinders reduce flow separation but decrease pressure recovery downstream. Riblets, passive porous surfaces, swept grooves, Helmholtz resonators, and arches and LEBU's with angle of attack less than or = 0 degrees had no significant effect in reducing the extent of the separation region. Wall-cooling computations indicated that separation delay on a partially-cooled ramp is nearly the same as on a fully-cooled ramp, while minimizing the frictional drag increase associated with the wall cooling process. Dry-flow visualization tests in the water tunnel indicated that wishbone vortex generators in the forward orientation shed horseshoe vortices; wishbone vortex generators oriented in the reverse direction and doublet vortex generators shed streamwise counterrotating vortices; a spanewise cylinder located near the wall and LEBU's at angle of attack = -10 degrees produced eddies or transverse vortices which rotated with the same sign as the mean vorticity in a turbulent boundary layer; and the most effective VGJ's produced streamwise co-rotating vortices. Comparative wind-tunnel test results indicated that transferring momentum from the outer region of a turbulent boundary layer through the action of embedded streamwise vortices is more effective than by transverse vortices for the separation control application studied herein.

On-line fast response device and method for measuring dissolved gas in a fluid

DOEpatents

Tutu, Narinder Kumar [Manorville, NY

2011-01-11

A method and device for the measurement of dissolved gas within a fluid. The fluid, substantially a liquid, is pumped into a pipe. The flow of the fluid is temporally restricted, creating one or more low pressure regions. A measurement indicative of trapped air is taken before and after the restriction. The amount of dissolved air is calculated from the difference between the first and second measurements. Preferably measurements indicative of trapped air is obtained from one or more pressure transducers, capacitance transducers, or combinations thereof. In the alternative, other methods such as those utilizing x-rays or gamma rays may also be used to detect trapped air. Preferably, the fluid is a hydraulic fluid, whereby dissolved air in the fluid is detected.

Discharge Measurements in Shallow Urban Streams Using a Hydroacoustic Current Meter

USGS Publications Warehouse

Fisher, G.T.; Morlock, S.E.; ,

2002-01-01

Hydroacoustic current-meter measurements were evaluated in small urban streams under a range of stages, velocities, and channel-bottom materials. Because flow in urban streams is often shallow, conventional mechanical current-meter measurements are difficult or impossible to make. The rotating-cup Price pygmy meter that is widely used by the U.S. Geological Survey and other agencies should not be used in depths below 0.20 ft and velocities less than 0.30 ft/s. The hydroacoustic device provides measurements at depths as shallow as 0.10 ft and velocities as low as 0.10 ft/s or less. Measurements using the hydroacoustic current meter were compared to conventional discharge measurements. Comparisons with Price-meter measurements were favorable within the range of flows for which the meters are rated. Based on laboratory and field tests, velocity measurements with the hydroacoustic cannot be validated below about 0.07 ft/s. However, the hydroacoustic meter provides valuable information on direction and magnitude of flow even at lower velocities, which otherwise could not be measured with conventional measurements.

Computation of incompressible viscous flows through artificial heart devices with moving boundaries

NASA Technical Reports Server (NTRS)

Kiris, Cetin; Rogers, Stuart; Kwak, Dochan; Chang, I.-DEE

1991-01-01

The extension of computational fluid dynamics techniques to artificial heart flow simulations is illustrated. Unsteady incompressible Navier-Stokes equations written in 3-D generalized curvilinear coordinates are solved iteratively at each physical time step until the incompressibility condition is satisfied. The solution method is based on the pseudo compressibility approach and uses an implicit upwind differencing scheme together with the Gauss-Seidel line relaxation method. The efficiency and robustness of the time accurate formulation of the algorithm are tested by computing the flow through model geometries. A channel flow with a moving indentation is computed and validated with experimental measurements and other numerical solutions. In order to handle the geometric complexity and the moving boundary problems, a zonal method and an overlapping grid embedding scheme are used, respectively. Steady state solutions for the flow through a tilting disk heart valve was compared against experimental measurements. Good agreement was obtained. The flow computation during the valve opening and closing is carried out to illustrate the moving boundary capability.

Interactive Retinal Blood Flow Analysis of the Macular Region

PubMed Central

Tian, Jing; Somfai, Gábor Márk; Campagnoli, Thalmon R.; Smiddy, William E.; Debuc, Delia Cabrera

2015-01-01

The study of retinal hemodynamics plays an important role to understand the onset and progression of diabetic retinopathy which is a leading cause of blindness in American adults. In this work, we developed an interactive retinal analysis tool to quantitatively measure the blood flow velocity (BFV) and blood flow rate (BFR) in the macular region using the Retinal Function Imager (RFI-3005, Optical Imaging, Rehovot, Israel). By employing a high definition stroboscopic fundus camera, the RFI device is able to assess retinal blood flow characteristics in vivo even in the capillaries. However, the measurements of BFV using a user-guided vessel segmentation tool may induce significant inter-observer differences and BFR is not provided in the built-in software. In this work, we have developed an interactive tool to assess the retinal BFV as well as BFR in the macular region. Optical coherence tomography (OCT) data from commercially available devices were registered with the RFI image to locate the fovea accurately. The boundaries of the vessels were delineated on a motion contrast enhanced image and BFV was computed by maximizing the cross-correlation of pixel intensities in a ratio video. Furthermore, we were able to calculate the BFR in absolute values (μl/s) which other currently available devices targeting the retinal microcirculation are not yet capable of. Experiments were conducted on 122 vessels from 5 healthy and 5 mild non-proliferative diabetic retinopathy (NPDR) subjects. The Pearson's correlation of the vessel diameter measurements between our method and manual labeling on 40 vessels was 0.984. The intraclass correlation (ICC) of BFV between our proposed method and built-in software were 0.924 and 0.830 for vessels from healthy and NPDR subjects, respectively. The coefficient of variation between repeated sessions was reduced significantly from 22.5% in the RFI built-in software to 15.9% in our proposed method (p<0.001). PMID:26569349

Measuring the mechanical efficiency of a working cardiac muscle sample at body temperature using a flow-through calorimeter.

PubMed

Taberner, Andrew J; Johnston, Callum M; Pham, Toan; June-Chiew Han; Ruddy, Bryan P; Loiselle, Denis S; Nielsen, Poul M F

2015-08-01

We have developed a new `work-loop calorimeter' that is capable of measuring, simultaneously, the work-done and heat production of isolated cardiac muscle samples at body temperature. Through the innovative use of thermoelectric modules as temperature sensors, the development of a low-noise fluid-flow system, and implementation of precise temperature control, the heat resolution of this device is 10 nW, an improvement by a factor of ten over previous designs. These advances have allowed us to conduct the first flow-through measurements of work output and heat dissipation from cardiac tissue at body temperature. The mechanical efficiency is found to vary with peak stress, and reaches a peak value of approximately 15 %, a figure similar to that observed in cardiac muscle at lower temperatures.

Aerodynamic drag reduction tests on a full-scale tractor-trailer combination with several add-on devices

NASA Technical Reports Server (NTRS)

Montoya, L. C.; Steers, L. L.

1974-01-01

Aerodynamic drag tests were performed on a conventional cab-over-engine tractor with a 45-foot trailer and five commercially available or potentially available add-on devices using the coast-down method. The tests ranged in velocity from approximately 30 miles per hour to 65 miles per hour and included some flow visualization. A smooth, level runway at Edwards Air Force Base was used for the tests, and deceleration measurements were taken with both accelerometers and stopwatches. An evaluation of the drag reduction results obtained with each of the five add-on devices is presented.

Cerebral blood flow - Comparison of ground-based and spaceflight data and correlation with space adaptation syndrome

NASA Technical Reports Server (NTRS)

Bagian, James P.; Hackett, Peter

1991-01-01

The relationship between the cerebral blood flow velocity and the space adaptation syndrome (SAS), which includes symptoms of motion sickness, stuffy head, and/or headaches, was investigated by measuring (using a transcranial Doppler device) differences between the preflight and the inflight cerebral blood flow velocity in crew members who were motion sick and in those who were not sick during a flight aboard KC-135. It was found that the cerebral artery bloodflow inflight did not differ significantly from that recorded preflight, nor did the severity of SAS symptoms correlate directly with the cerebral blood flow.

Computational Hemodynamics Involving Artificial Devices

NASA Technical Reports Server (NTRS)

Kwak, Dochan; Kiris, Cetin; Feiereisen, William (Technical Monitor)

2001-01-01

This paper reports the progress being made towards developing complete blood flow simulation capability in human, especially, in the presence of artificial devices such as valves and ventricular assist devices. Devices modeling poses unique challenges different from computing the blood flow in natural hearts and arteries. There are many elements needed such as flow solvers, geometry modeling including flexible walls, moving boundary procedures and physiological characterization of blood. As a first step, computational technology developed for aerospace applications was extended in the recent past to the analysis and development of mechanical devices. The blood flow in these devices is practically incompressible and Newtonian, and thus various incompressible Navier-Stokes solution procedures can be selected depending on the choice of formulations, variables and numerical schemes. Two primitive variable formulations used are discussed as well as the overset grid approach to handle complex moving geometry. This procedure has been applied to several artificial devices. Among these, recent progress made in developing DeBakey axial flow blood pump will be presented from computational point of view. Computational and clinical issues will be discussed in detail as well as additional work needed.

Observation of turbulent-driven shear flow in a cylindrical laboratory plasma device.

PubMed

Holland, C; Yu, J H; James, A; Nishijima, D; Shimada, M; Taheri, N; Tynan, G R

2006-05-19

An azimuthally symmetric radially sheared plasma fluid flow is observed to spontaneously form in a cylindrical magnetized helicon plasma device with no external sources of momentum input. A turbulent momentum conservation analysis shows that this shear flow is sustained by the Reynolds stress generated by collisional drift turbulence in the device. The results provide direct experimental support for the basic theoretical picture of drift-wave-shear-flow interactions.

Study on molecular sieve absorption of ground state HF molecules in a non-chain pulsed HF Laser

NASA Astrophysics Data System (ADS)

Ma, Lianying; Zhou, Songqing; Chao, Huang; Huang, Ke; Zhu, Feng; Luan, Kunpeng; Chen, Hongwei

2017-05-01

This paper describes the principle of non-chain pulsed HF laser, and analyzes the reason why the laser energy dropped severely with the accumulation of shots when the HF laser was in repetitive operation. In order to solve this problem, a molecular sieve absorption device was designed and mounted in the recirculation loop of the HF laser. Measurements of flow velocity indicated that the absorption device would just introduce a small decrease of flow velocity which would not influence the laser operation. Several types of molecular sieve (3A,4A,5A,13X) were used in absorbing experiments and the experiment results inferred that 3A molecular sieve was the most effective sorbent. All the experiments showed that the average drop of the output energy was not more than 5% after 1000 shots at 50Hz/20s. Compared to the energy drop of about 40% without the device, the absorption device could significantly improve the stability of the HF laser output energy and prolong the lifespan of laser medium gases.

Design optimization for accurate flow simulations in 3D printed vascular phantoms derived from computed tomography angiography

NASA Astrophysics Data System (ADS)

Sommer, Kelsey; Izzo, Rick L.; Shepard, Lauren; Podgorsak, Alexander R.; Rudin, Stephen; Siddiqui, Adnan H.; Wilson, Michael F.; Angel, Erin; Said, Zaid; Springer, Michael; Ionita, Ciprian N.

2017-03-01

3D printing has been used to create complex arterial phantoms to advance device testing and physiological condition evaluation. Stereolithographic (STL) files of patient-specific cardiovascular anatomy are acquired to build cardiac vasculature through advanced mesh-manipulation techniques. Management of distal branches in the arterial tree is important to make such phantoms practicable. We investigated methods to manage the distal arterial flow resistance and pressure thus creating physiologically and geometrically accurate phantoms that can be used for simulations of image-guided interventional procedures with new devices. Patient specific CT data were imported into a Vital Imaging workstation, segmented, and exported as STL files. Using a mesh-manipulation program (Meshmixer) we created flow models of the coronary tree. Distal arteries were connected to a compliance chamber. The phantom was then printed using a Stratasys Connex3 multimaterial printer: the vessel in TangoPlus and the fluid flow simulation chamber in Vero. The model was connected to a programmable pump and pressure sensors measured flow characteristics through the phantoms. Physiological flow simulations for patient-specific vasculature were done for six cardiac models (three different vasculatures comparing two new designs). For the coronary phantom we obtained physiologically relevant waves which oscillated between 80 and 120 mmHg and a flow rate of 125 ml/min, within the literature reported values. The pressure wave was similar with those acquired in human patients. Thus we demonstrated that 3D printed phantoms can be used not only to reproduce the correct patient anatomy for device testing in image-guided interventions, but also for physiological simulations. This has great potential to advance treatment assessment and diagnosis.

SU-E-J-48: Development of An Abdominal Compression Device for Respiratory Correlated Radiation Therapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, T; Kang, S; Kim, D

Purpose: The aim of this study is to develop the abdominal compression device which could control pressure level according to the abdominal respiratory motion and evaluate its feasibility. Methods: In this study, we focused on developing the abdominal compression device which could control pressure level at any point of time so the developed device is possible to use a variety of purpose (gating technique or respiratory training system) while maintaining the merit of the existing commercial device. The compression device (air pad form) was designed to be able to compress the front and side of abdomen and the pressure levelmore » of the abdomen is controlled by air flow. Pressure level of abdomen (air flow) was determined using correlation data between external abdominal motion and respiratory volume signal measured by spirometer. In order to verify the feasibility of the device, it was necessary to confirm the correlation between the abdominal respiratory motion and respiratory volume signal and cooperation with respiratory training system also checked. Results: In the previous study, we could find that the correlation coefficient ratio between diaphragm and respiratory volume signal measured by spirometer was 0.95. In this study, we confirmed the correlation between the respiratory volume signal and the external abdominal motion measured by belt-transducer (correlation coefficient ratio was 0.92) and used the correlated respiratory volume data as an abdominal pressure level. It was possible to control the pressure level with negligible time delay and respiratory volume data based guiding waveforms could be properly inserted into the respiratory training system. Conclusion: Through this feasibility study, we confirmed the correlation between the respiratory volume signal and the external abdominal motion. Also initial assessment of the device and its compatibility with the respiratory training system were verified. Further study on application in respiratory gated therapy and respiratory training system will be investigated. This work was supported by Radiation Technology R and D program (No. 2013M2A2A7043498)and Basic Atomic Energy Research Institute (BAERI)(No. NRF-2009-0078390) through the National Research Foundation of Korea funded by the Ministry of Science, ICT and Future Planning.« less

In Situ Soil Venting - Full Scale Test, Hill AFB, Guidance Document. Volume 2

DTIC Science & Technology

1991-08-01

oxidizer. Another system was connected to the existing air scrubber of a building (Reference 23). The self-contained unit reported by Rippberger...devices on the market for flow rate measurement. Some of the more common devices are orifice meters, venturi meters, rotameters, pitot tubes, hot-wire...Notes on how to size and construct orifice meters can be found in Reference 41. * Venturi Meter - A venturi meter works basically on the same

PIV Investigations of the Flow Field in the Volute of a Rotary Blood Pump

NASA Technical Reports Server (NTRS)

Sankovic, John M.; Kadambi, Jaikrishnan R.; Mehta, Mehul; Smith, William A.; Wernet, Mark P.

2004-01-01

A full-size acrylic model of a rotary blood pump was developed in order to utilize Particle Image Velocimetry (PIV) to make measurements of the fluid velocities and turbulent stresses throughout the device. The development of an understanding of the hemodynamics within the blood pump is critical to the development and validation of computational models. A blood analog solution, consisting of sodium iodide solution and glycerin, was developed to match physiological kinematic viscosity. The refractive indecies of the fluid, the pump casing and the impeller were matched to facilitate the use of PIV to make velocity measurements. Velocity measurements made in the volute exit/diffuser region are presented for pumps speeds of 3000-3850 rpm. At each speed data were obtained at a physiological pressure of 90 mmHg and at a maximum flow condition. Four hundred data pairs were used for each resultant mean velocity vector value, representing greater than an order of magnitude more data pairs than reported previously in the literature on similar devices and resulting in velocity uncertainty levels of approximately 2.9%.

PIV Investigations of the Flow Field in the Volute of a Rotary Blood Pump

NASA Technical Reports Server (NTRS)

Sankovic, John M.; Kadambi, Jaikrishnan R.; Smith, William A.; Wernet, Mark P.

2004-01-01

A full-size acrylic model of a rotary blood pump was developed in order to utilize Particle Image Velocimetry (PIV) to make measurements of the fluid velocities and turbulent stresses throughout the device. The development of an understanding of the hemodynamics within the blood pump is critical to the development and validation of computational models. A blood analog solution, consisting of sodium iodide solution and glycerin, was developed to match physiological kinematic viscosity. The refractive indices of the fluid, the pump casing, and the impeller were matched to facilitate the use of PIV to make velocity measurements. Velocity measurements made in the volute exit/diffuser region are presented for pumps speeds of 3000-3850 rpm. At each speed data were obtained at a physiological pressure of 12 kPa and at a maximum flow condition. Four hundred data pairs were used for each resultant mean velocity vector value, representing greater than an order of magnitude more data pairs than reported previously in the literature on similar devices and resulting in velocity uncertainty levels of approximately 22.9%.

Set-up of debris-flow monitoring stations in the Eastern Pyrenees. Preliminary results and first experiences.

NASA Astrophysics Data System (ADS)

Hürlimann, Marcel; Abancó, Claudia; Moya, Jose; Chevalier, Guillaume; Raïmat, Carles; Luis-Fonseca, Roberto

2010-05-01

Direct observations of debris flows in the field by monitoring stations are of great importance to improve understandings of triggering, flow behaviour and accumulation of debris flows. Upon the knowledge of the authors, in Europe debris-flow monitoring stations are only situated in the Alps (Italy and Switzerland), while no test site is located in a catchment affected by Mediterranean climate. In 2005, the first monitoring system was set up by GEOBRUGG IBERICA SA in the Erill catchment, situated in the Axial Pyrenees. A flexible ring net VX160-H4 with load-cells was installed together with a video camera and four geophones. In addition, a meteorological station completed the instrumentation. During 2009, the monitoring of two additional catchments has been set up; Senet in the Axial Pyrenees and Ensija in the Pre-Pyrenees. Four geophones and one ultrasonic device are installed along the torrent in order to determine the flow velocity and flow depth/discharge of the events. As in Erill, a meteorological station completes the devices and measures rainfall and temperature. The main objective of the three monitoring stations is to get some insights on how the Mediterranean climate influences the critical rainfall for debris-flow initiation. The flow behaviour of debris flows is another major goal, while the Erill test site focuses basically on the effectiveness of flexible ring nets. In addition, the Erill installation also acts as protection for the village located on the fan. The calibration, installation and analysis during the testing phase showed that a correct implementation of the different sensors is not an easy task and needs knowledge in geophysics, electronics, telecommunications etc. Especially geophones and ultrasonic devices need special attentions. Geophone outputs are strongly affected by the type of underground and the distance to the torrent, while the measures of the ultrasonic sensor clearly depend on the temperature. To simplify the data storage and processing, geophone signals are converted into impulses. This involves definition of a threshold to filter seismic "noise" caused by other processes. An additional difficulty in our test sites is the remoteness, which needs an independent power supply by solar panels and GSM-transmission of the data gathered. In Senet and Ensija catchment, hyperconcentrated flows have been observed during summer 2009 by field surveys, although these events could not have been clearly detected by the geophones and the ultrasonic device. Thus, only the critical rainfall amount for generating such type of flows could be analysed. These data support the hypothesis that short-lasting and intensive summer storms are common triggering precipitations for hyperconcentrated flows and also for debris flows. In Erill, three small events with volumes of a few hundreds of cubic-meters have been occurred till now. All of them were stopped by the flexible ring barrier, while the barrier has been self-cleaned by the natural dynamics of the stream. Such events (hyperconcentrated flows) are allegedly exceptional; therefore the flows have been generated as consequence of high intensity rainfall, very common in this area. For this reason it's thought that the debris flow phenomenon and the trigger conditions should be studied in detail, to achieve the required knowledge to calculate the future impact loads and scenarios.

Nematic director reorientation at solid and liquid interfaces under flow: SAXS studies in a microfluidic device

DOE PAGES

Silva, Bruno F. B.; Zepeda-Rosales, Miguel; Venkateswaran, Neeraja; ...

2014-10-30

In this work we investigate the interplay between flow and boundary condition effects on the orientation field of a thermotropic nematic liquid crystal under flow and confinement in a microfluidic device. Two types of experiments were performed using synchrotron small-angle X-ray-scattering (SAXS). In the first, a nematic liquid crystal flows through a square-channel cross section at varying flow rates, while the nematic director orientation projected onto the velocity/velocity gradient plane is measured using a 2D detector. At moderate-to-high flow rates, the nematic director is predominantly aligned in the flow direction, but with a small tilt angle of ~±11° in themore » velocity gradient direction. The director tilt angle is constant throughout most of the channel width but switches sign when crossing the center of the channel, in agreement with the Ericksen–Leslie–Parodi (ELP) theory. At low flow rates, boundary conditions begin to dominate, and a flow profile resembling the escaped radial director configuration is observed, where the director is seen to vary more smoothly from the edges (with homeotropic alignment) to the center of the channel. In the second experiment, hydrodynamic focusing is employed to confine the nematic phase into a sheet of liquid sandwiched between two layers of Triton X-100 aqueous solutions. The average nematic director orientation shifts to some extent from the flow direction toward the liquid boundaries, although it remains unclear if one tilt angle is dominant through most of the nematic sheet (with abrupt jumps near the boundaries) or if the tilt angle varies smoothly between two extreme values (~90 and 0°). Lastly, the technique presented here could be applied to perform high-throughput measurements for assessing the influence of different surfactants on the orientation of nematic phases and may lead to further improvements in areas such as boundary lubrication and clarifying the nature of defect structures in LC displays.« less

High Temperature Tribometer. Phase 1

DTIC Science & Technology

1989-06-01

13 Figure 2.3.2 Setpoint and Gain Windows in FW.EXE ......... . Figure 2.4.1 Data-Flow Diagram for Data-Acquisition Module ..... .. 23 I Figure...mounted in a friction force measuring device. Optimally , material testing results should not be test machine sensitiye; but due to equipment variables...fixed. The friction force due to sliding should be continuously measured. This is optimally done in conjunction with the normal force measurement via

Open-channel integrating-type flow meter

USGS Publications Warehouse

Koopman, K.C.

1971-01-01

A relatively inexpensive meter for measuring cumulative flow in open channels with a rated control,. called a "totalizer", was developed. It translates the nonlinear function of gage height to flow by use of a cam and a float. A variable resistance element in an electronic circuit is controlled by the float so that the electron flow in the circuit corresponds to the flow of water. The flow of electricity causes electroplating of an electrode with silver. The amount of silver deposited is proportionate to the flow of water. The total flow of water is determined by removing the silver from the electrode at a fixed rate with ·an electronic device and recording the time for removal with a counter. The circuit is designed so that the ,resultant reading on the counter is in acre-feet of water.

Highly sensitive silicon microreactor for catalyst testing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Henriksen, Toke R.; Hansen, Ole; Department of Physics, Danish National Research Foundation's Center for Individual Nanoparticle Functionality

2009-12-15

A novel microfabricated chemical reactor for highly sensitive measurements of catalytic activity and surface kinetics is presented. The reactor is fabricated in a silicon chip and is intended for gas-phase reactions at pressures ranging from 0.1 to 5.0 bar. A high sensitivity is obtained by directing the entire gas flow through the catalyst bed to a mass spectrometer, thus ensuring that nearly all reaction products are present in the analyzed gas flow. Although the device can be employed for testing a wide range of catalysts, the primary aim of the design is to allow characterization of model catalysts which canmore » only be obtained in small quantities. Such measurements are of significant fundamental interest but are challenging because of the low surface areas involved. The relationship between the reaction zone gas flow and the pressure in the reaction zone is investigated experimentally. A corresponding theoretical model is presented, and the gas flow through an on-chip flow-limiting capillary is predicted to be in the intermediate regime. The experimental data for the gas flow are found to be in good agreement with the theoretical model. At typical experimental conditions, the total gas flow through the reaction zone is around 3x10{sup 14} molecules s{sup -1}, corresponding to a gas residence time in the reaction zone of about 11 s. To demonstrate the operation of the microreactor, CO oxidation on low-area platinum thin film circles is employed as a test reaction. Using temperature ramping, it is found that platinum catalysts with areas as small as 15 {mu}m{sup 2} are conveniently characterized with the device.« less

Milking performance evaluation and factors affecting milking claw vacuum levels with flow simulator.

PubMed

Enokidani, Masafumi; Kawai, Kazuhiro; Shinozuka, Yasunori; Watanabe, Aiko

2017-08-01

Milking performance of milking machines that matches the production capability of dairy cows is important in reducing the risk of mastitis, particularly in high-producing cows. This study used a simulated milking device to examine the milking performance of the milking system of 73 dairy farms and to analyze the factors affecting claw vacuum. Mean claw vacuum and range of fluctuation of claw vacuum (claw vacuum range) were measured at three different flow rates: 5.7, 7.6 and 8.7 kg/min. At the highest flow rate, only 16 farms (21.9%) met both standards of mean claw vacuum ≥35 kPa and claw vacuum range ≤ 7 kPa, showing that milking systems currently have poor milking performance. The factors affecting mean claw vacuum were claw type, milk-meter and vacuum shut-off device; the factor affecting claw vacuum range was claw type. Examination of the milking performance of the milking system using a simulated milking device allows an examination of the performance that can cope with high producing cows, indicating the possibility of reducing the risk of mastitis caused by inappropriate claw vacuum. © 2016 Japanese Society of Animal Science.

High Temperature Propulsion System Structural Seals for Future Space Launch Vehicles

NASA Technical Reports Server (NTRS)

Dunlap, Patrick H., Jr.; Steinetz, Bruce M.; DeMange, Jeffrey J.

2004-01-01

Durable, flexible sliding seals are required in advanced hypersonic engines to seal the perimeters of movable engine ramps for efficient, safe operation in high heat flux environments at temperatures of 2000 to 2500 F. Current seal designs do not meet the demanding requirements for future engines, so NASA s Glenn Research Center is developing advanced seals and preloading devices to overcome these shortfalls. An advanced ceramic wafer seal design and two types of seal preloading devices were evaluated in a series of compression, scrub, and flow tests. Silicon nitride wafer seals survived 2000 in. 1000 cycles) of scrubbing at 1600 F against an Inconel 625 rub surface with no chips or signs of damage. Flow rates measured for the wafers before and after scrubbing were almost identical and were up to 32 times lower than those recorded for the best braided rope seal flow blockers. Canted coil springs and silicon nitride compression springs showed promise conceptually as potential seal preloading devices to help maintain seal resiliency. A finite element model of the canted coil spring revealed that it should be possible to produce a spring out of high temperature materials for applications at 2000+ F.

High Temperature Propulsion System Structural Seals for Future Space Launch Vehicles

NASA Technical Reports Server (NTRS)

Dunlap, Patrick H., Jr.; Steinetz, Bruce M.; DeMange, Jeffrey J.

2003-01-01

Durable, flexible sliding seals are required in advanced hypersonic engines to seal the perimeters of movable engine ramps for efficient, safe operation in high heat flux environments at temperatures of 2000 to 2500 F. Current seal designs do not meet the demanding requirements for future engines, so NASA's Glenn Research Center is developing advanced seals and preloading devices to overcome these shortfalls. An advanced ceramic wafer seal design and two types of seal preloading devices were evaluated in a series of compression, scrub, and flow tests. Silicon nitride wafer seals survived 2000 in. (1000 cycles) of scrubbing at room temperature against an Inconel 625 rub surface with no chips or signs of damage. Flow rates measured for the wafers before and after scrubbing were almost identical and were much lower than those recorded for the best braided rope seal flow blockers. Canted coil springs and silicon nitride compression springs showed promise conceptually as potential seal preloading devices to help maintain seal resiliency. A finite element model of the canted coil spring revealed that it should be possible to produce a spring out of high temperature materials for applications at 2000+ F.

Deformability measurement of red blood cells using a microfluidic channel array and an air cavity in a driving syringe with high throughput and precise detection of subpopulations.

PubMed

Kang, Yang Jun; Ha, Young-Ran; Lee, Sang-Joon

2016-01-07

Red blood cell (RBC) deformability has been considered a potential biomarker for monitoring pathological disorders. High throughput and detection of subpopulations in RBCs are essential in the measurement of RBC deformability. In this paper, we propose a new method to measure RBC deformability by evaluating temporal variations in the average velocity of blood flow and image intensity of successively clogged RBCs in the microfluidic channel array for specific time durations. In addition, to effectively detect differences in subpopulations of RBCs, an air compliance effect is employed by adding an air cavity into a disposable syringe. The syringe was equally filled with a blood sample (V(blood) = 0.3 mL, hematocrit = 50%) and air (V(air) = 0.3 mL). Owing to the air compliance effect, blood flow in the microfluidic device behaved transiently depending on the fluidic resistance in the microfluidic device. Based on the transient behaviors of blood flows, the deformability of RBCs is quantified by evaluating three representative parameters, namely, minimum value of the average velocity of blood flow, clogging index, and delivered blood volume. The proposed method was applied to measure the deformability of blood samples consisting of homogeneous RBCs fixed with four different concentrations of glutaraldehyde solution (0%-0.23%). The proposed method was also employed to evaluate the deformability of blood samples partially mixed with normal RBCs and hardened RBCs. Thereafter, the deformability of RBCs infected by human malaria parasite Plasmodium falciparum was measured. As a result, the three parameters significantly varied, depending on the degree of deformability. In addition, the deformability measurement of blood samples was successfully completed in a short time (∼10 min). Therefore, the proposed method has significant potential in deformability measurement of blood samples containing hematological diseases with high throughput and precise detection of subpopulations in RBCs.

The Effect of Acoustic Disturbances on the Operation of the Space Shuttle Main Engine Fuel Flowmeter

NASA Technical Reports Server (NTRS)

Marcu, Bogdan; Szabo, Roland; Dorney, Dan; Zoladz, Tom

2007-01-01

The Space Shuttle Main Engine (SSME) uses a turbine fuel flowmeter (FFM) in its Low Pressure Fuel Duct (LPFD) to measure liquid hydrogen flowrates during engine operation. The flowmeter is required to provide accurate and robust measurements of flow rates ranging from 10000 to 18000 GPM in an environment contaminated by duct vibration and duct internal acoustic disturbances. Errors exceeding 0.5% can have a significant impact on engine operation and mission completion. The accuracy of each sensor is monitored during hot-fire engine tests on the ground. Flow meters which do not meet requirements are not flown. Among other parameters, the device is screened for a specific behavior in which a small shift in the flow rate reading is registered during a period in which the actual fuel flow as measured by a facility meter does not change. Such behavior has been observed over the years for specific builds of the FFM and must be avoided or limited in magnitude in flight. Various analyses of the recorded data have been made prior to this report in an effort to understand the cause of the phenomenon; however, no conclusive cause for the shift in the instrument behavior has been found. The present report proposes an explanation of the phenomenon based on interactions between acoustic pressure disturbances in the duct and the wakes produced by the FFM flow straightener. Physical insight into the effects of acoustic plane wave disturbances was obtained using a simple analytical model. Based on that model, a series of three-dimensional unsteady viscous flow computational fluid dynamics (CFD) simulations were performed using the MSFC PHANTOM turbomachinery code. The code was customized to allow the FFM rotor speed to change at every time step according to the instantaneous fluid forces on the rotor, that, in turn, are affected by acoustic plane pressure waves propagating through the device. The results of the simulations show the variation in the rotation rate of the flowmeter due to the interaction of the flow straightener wakes and the upstream propagating acoustic waves. A detailed analysis of the acoustic disturbance effects is presented along with an assessment of the impact on measurement accuracy.

Quantification of methane fluxes from hydrocarbon seeps to the ocean and atmosphere: Development of an in situ and online gas flux measuring system

NASA Astrophysics Data System (ADS)

Di, Pengfei; Chen, Qinghua; Chen, Duofu

2017-06-01

Natural hydrocarbon seeps in the marine environment are important contributors to greenhouse gases in the atmosphere. Such gases include methane, which plays a significant role in global carbon cycling and climate change. To accurately quantify the methane flux from hydrocarbon seeps on the seafloor, a specialized in situ and online gas flux measuring (GFM) device was designed to obtain high-resolution time course gas fluxes using the process of equal volume exchange. The device consists of a 1.0-m diameter, 0.9-m tall, inverted conical tent and a GFM instrument that contains a solenoid valve, level transducer, and gas collection chamber. Rising gas bubbles from seeps were measured by laboratory-calibrated GFM instruments attached to the top of the tent. According to the experimental data, the optimal anti-shake time interval was 5 s. The measurement range of the device was 0-15 L min-1, and the relative error was ± 1.0%. The device was initially deployed at an active seep site in the Lingtou Promontory seep field in South China Sea. The amount of gas released from a single gas vent was 30.5 m3 during the measurement period, and the gas flow rate ranged from 22 to 72 L h-1, depending on tidal period, and was strongly negatively correlated with water depth. The measurement results strongly suggest that oceanic tides and swells had a significant forcing effect on gas flux. Low flow rates were associated with high tides and vice versa. The changes in gas volume escaping from the seafloor seeps could be attributed to the hydrostatic pressure induced by water depth. Our findings suggest that in the marine environment, especially in the shallow shelf area, sea level variation may play an important role in controlling methane release into the ocean. Such releases probably also affect atmospheric methane levels.

Combined effect of moisture and electrostatic charges on powder flow

NASA Astrophysics Data System (ADS)

Rescaglio, Antonella; Schockmel, Julien; Vandewalle, Nicolas; Lumay, Geoffroy

2017-06-01

It is well known in industrial applications involving powders and granular materials that the relative air humidity and the presence of electrostatic charges influence drastically the material flowing properties. The relative air humidity induces the formation of capillary bridges and modify the grain surface conductivity. The presence of capillary bridges produces cohesive forces. On the other hand, the apparition of electrostatic charges due to the triboelectric effect at the contacts between the grains and at the contacts between the grains and the container produces electrostatic forces. Therefore, in many cases, the powder cohesiveness is the result of the interplay between capillary and electrostatic forces. Unfortunately, the triboelectric effect is still poorly understood, in particular inside a granular material. Moreover, reproducible electrostatic measurements are difficult to perform. We developed an experimental device to measures the ability of a powder to charge electrostatically during a flow in contact with a selected material. Both electrostatic and flow measurements have been performed in different hygrometric conditions. The correlation between the powder electrostatic properties, the hygrometry and the flowing behavior are analyzed.

Experimental and numeric investigation of Impella pumps as cavopulmonary assistance for a failing Fontan.

PubMed

Haggerty, Christopher M; Fynn-Thompson, Francis; McElhinney, Doff B; Valente, Anne Marie; Saikrishnan, Neelakantan; Del Nido, Pedro J; Yoganathan, Ajit P

2012-09-01

This study sought to evaluate the performance of microaxial ventricular assist devices for the purposes of supporting failing Fontan physiology by decreasing central venous pressure. Three Abiomed Impella pumps (Abiomed, Inc, Danvers, Mass) were evaluated in a mock circulatory system of the Fontan circuit. The local response of pressures and flows to pump function was assessed as a function of pump speed and pulmonary vascular resistance at a high baseline central venous pressure. For one device, subsequent modeling studies were conducted using a lumped parameter model of the single ventricle circuit. The left ventricular devices (Impella 2.5, 5.0) were shown to be suboptimal as single device solutions for cavopulmonary support. The small area of these devices relative to vessel diameter led to significant flow recirculation without an obstructive separator in place. Furthermore, downstream pressure augmentation adversely affected the pressure in the superior vena cava. The use of 2 devices would be mandatory for successful support. The right-sided device (Impella RP), whose outflow was positioned in the left pulmonary artery, demonstrated decreased flow recirculation and did not impede superior caval venous flow. Although static pressure is still required to drive flow through the opposite lung, numeric modeling demonstrated the potential for modest but significant improvements in lowering the central venous pressure (2-8 mm Hg). Left-sided microaxial pumps are not well suited for cavopulmonary support because of severe flow recirculation and the need for multiple devices. The right-ventricular Impella device provides improved performance by directing flow into the pulmonary artery, resulting in modest decreases in central venous pressure. Copyright © 2012 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.

THERMAL COUPLE FOR MEASURING TEMPERATURE IN A REACTOR

DOEpatents

Kanne, W.

1959-11-24

A thermocouple device for measuring the temperature of a flowing fluid in a conduit within which is positioned a metallic rod is presented. A thermocouple junction is secured to the rod centrally, and thermal insulating support disks having a diameter greater than the rod are secured to the end portions of the rod and adapted to fit transversely in the conduit.

Blood Pump Development Using Rocket Engine Flow Simulation Technology

NASA Technical Reports Server (NTRS)

Kwak, Dochan; Kiris, Cetin

2001-01-01

This paper reports the progress made towards developing complete blood flow simulation capability in humans, especially in the presence of artificial devices such as valves and ventricular assist devices. Devices modeling poses unique challenges different from computing the blood flow in natural hearts and arteries. There are many elements needed to quantify the flow in these devices such as flow solvers, geometry modeling including flexible walls, moving boundary procedures and physiological characterization of blood. As a first step, computational technology developed for aerospace applications was extended to the analysis and development of a ventricular assist device (VAD), i.e., a blood pump. The blood flow in a VAD is practically incompressible and Newtonian, and thus an incompressible Navier-Stokes solution procedure can be applied. A primitive variable formulation is used in conjunction with the overset grid approach to handle complex moving geometry. The primary purpose of developing the incompressible flow analysis capability was to quantify the flow in advanced turbopump for space propulsion system. The same procedure has been extended to the development of NASA-DeBakey VAD that is based on an axial blood pump. Due to massive computing requirements, high-end computing is necessary for simulating three-dimensional flow in these pumps. Computational, experimental, and clinical results are presented.

Energetics of jellyfish locomotion determined from field measurements using a Self- Contained Underwater Velocimetry Apparatus (SCUVA)

NASA Astrophysics Data System (ADS)

Katija, K.; Dabiri, J. O.

2007-12-01

We conduct laboratory measurements of the flow fields induced by Aurelia labiata over a range of sizes using the method of digital particle image velocimetry (DPIV). The flow field measurements are used to directly quantify the kinetic energy induced by the swimming motions of individual medusae. This method provides details regarding the temporal evolution of the energetics during a swimming cycle and its scaling with bell diameter. These types of measurements also allow for the determination of propulsive efficiency, which can be used to compare various methods of propulsion, both biological and artificial. We then describe the development and application of a Self-Contained Underwater Velocimetry Apparatus (SCUVA), a device that enables a single SCUBA diver to make DPIV measurements of animal-fluid interactions in the field. Improvements and adjustments made to the original system will be presented, and a comparison between the animal-induced flow fields in the laboratory and in the field will be made.

Conformable amplified lead zirconate titanate sensors with enhanced piezoelectric response for cutaneous pressure monitoring.

PubMed

Dagdeviren, Canan; Su, Yewang; Joe, Pauline; Yona, Raissa; Liu, Yuhao; Kim, Yun-Soung; Huang, YongAn; Damadoran, Anoop R; Xia, Jing; Martin, Lane W; Huang, Yonggang; Rogers, John A

2014-08-05

The ability to measure subtle changes in arterial pressure using devices mounted on the skin can be valuable for monitoring vital signs in emergency care, detecting the early onset of cardiovascular disease and continuously assessing health status. Conventional technologies are well suited for use in traditional clinical settings, but cannot be easily adapted for sustained use during daily activities. Here we introduce a conformal device that avoids these limitations. Ultrathin inorganic piezoelectric and semiconductor materials on elastomer substrates enable amplified, low hysteresis measurements of pressure on the skin, with high levels of sensitivity (~0.005 Pa) and fast response times (~0.1 ms). Experimental and theoretical studies reveal enhanced piezoelectric responses in lead zirconate titanate that follow from integration on soft supports as well as engineering behaviours of the associated devices. Calibrated measurements of pressure variations of blood flow in near-surface arteries demonstrate capabilities for measuring radial artery augmentation index and pulse pressure velocity.

Rotating permanent magnet excitation for blood flow measurement.

PubMed

Nair, Sarath S; Vinodkumar, V; Sreedevi, V; Nagesh, D S

2015-11-01

A compact, portable and improved blood flow measurement system for an extracorporeal circuit having a rotating permanent magnetic excitation scheme is described in this paper. The system consists of a set of permanent magnets rotating near blood or any conductive fluid to create high-intensity alternating magnetic field in it and inducing a sinusoidal varying voltage across the column of fluid. The induced voltage signal is acquired, conditioned and processed to determine its flow rate. Performance analysis shows that a sensitivity of more than 250 mV/lpm can be obtained, which is more than five times higher than conventional flow measurement systems. Choice of rotating permanent magnet instead of an electromagnetic core generates alternate magnetic field of smooth sinusoidal nature which in turn reduces switching and interference noises. These results in reduction in complex electronic circuitry required for processing the signal to a great extent and enable the flow measuring device to be much less costlier, portable and light weight. The signal remains steady even with changes in environmental conditions and has an accuracy of greater than 95%. This paper also describes the construction details of the prototype, the factors affecting sensitivity and detailed performance analysis at various operating conditions.

Depth-resolved measurement of ocular fundus pulsations by low-coherence tissue interferometry

NASA Astrophysics Data System (ADS)

Dragostinoff, Nikolaus; Werkmeister, René M.; Gröschl, Martin; Schmetterer, Leopold

2009-09-01

A device that allows for the measurement of ocular fundus pulsations at preselected axial positions of a subject's eye is presented. Unlike previously presented systems, which only allow for observation of the strongest reflecting retinal layer, our system enables the measurement of fundus pulsations at a preselected ocular layer. For this purpose the sample is illuminated by light of low temporal coherence. The layer is then selected by positioning one mirror of a Michelson interferometer according to the depth of the layer. The device contains a length measurement system based on partial coherence interferometry and a line scan charge-coupled device camera for recording and online inspection of the fringe system. In-vivo measurements in healthy humans are performed as proof of principle. The algorithms used for enhancing the recorded images are briefly introduced. The contrast of the observed interference pattern is evaluated for different positions of the measurement mirror and at various distances from the front surface of the cornea. The applications of such a system may be wide, including assessment of eye elongation during myopia development and blood-flow-related changes in intraocular volume.

Determining a membrane's shear modulus, independent of its area-dilatation modulus, via capsule flow in a converging micro-capillary.

PubMed

Dimitrakopoulos, P; Kuriakose, S

2015-04-14

Determination of the elastic properties of the membrane of artificial capsules is essential for the better design of the various devices that are utilized in their engineering and biomedical applications. However this task is complicated owing to the combined effects of the shear and area-dilatation moduli on the capsule deformation. Based on computational investigation, we propose a new methodology to determine a membrane's shear modulus, independent of its area-dilatation modulus, by flowing strain-hardening capsules in a converging micro-capillary of comparable size under Stokes flow conditions, and comparing the experimental measurements of the capsule elongation overshooting with computational data. The capsule prestress, if any, can also be determined with the same methodology. The elongation overshooting is practically independent of the viscosity ratio for low and moderate viscosity ratios, and thus a wide range of capsule fluids can be employed. Our proposed experimental device can be readily produced via glass fabrication while owing to the continuous flow in the micro-capillary, the characterization of a large number of artificial capsules is possible.

A fast sampling device for the mass spectrometric analysis of liquid rocket engine exhaust

NASA Technical Reports Server (NTRS)

Ryason, P. R.

1975-01-01

The design of a device to obtain compositional data on rocket exhaust by direct sampling of reactive flow exhausts into a mass spectrometer is presented. Sampling at three stages differing in pressure and orifice angle and diameter is possible. Results of calibration with pure gases and gas mixtures are erratic and of unknown accuracy for H2, limiting the usefulness of the apparatus for determining oxidizer/fuel ratios from combustion product analysis. Deposition effects are discussed, and data obtained from rocket exhaust spectra are analyzed to give O/F ratios and mixture ratio distribution. The O/F ratio determined spectrometrically is insufficiently accurate for quantitative comparison with cold flow data. However, a criterion for operating conditions with improved mixing of fuel and oxidizer which is consistent with cold flow results may be obtained by inspection of contour plots. A chemical inefficiency in the combustion process when oxidizer is in excess is observed from reactive flow measurements. Present results were obtained with N2O4/N2H4 propellants.

Contrast-enhanced time-resolved MRA for follow-up of intracranial aneurysms treated with the pipeline embolization device.

PubMed

Boddu, S R; Tong, F C; Dehkharghani, S; Dion, J E; Saindane, A M

2014-01-01

Endovascular reconstruction and flow diversion by using the Pipeline Embolization Device is an effective treatment for complex cerebral aneurysms. Accurate noninvasive alternatives to DSA for follow-up after Pipeline Embolization Device treatment are desirable. This study evaluated the accuracy of contrast-enhanced time-resolved MRA for this purpose, hypothesizing that contrast-enhanced time-resolved MRA will be comparable with DSA and superior to 3D-TOF MRA. During a 24-month period, 37 Pipeline Embolization Device-treated intracranial aneurysms in 26 patients underwent initial follow-up by using 3D-TOF MRA, contrast-enhanced time-resolved MRA, and DSA. MRA was performed on a 1.5T unit by using 3D-TOF and time-resolved imaging of contrast kinetics. All patients underwent DSA a median of 0 days (range, 0-68) after MRA. Studies were evaluated for aneurysm occlusion, quality of visualization of the reconstructed artery, and measurable luminal diameter of the Pipeline Embolization Device, with DSA used as the reference standard. The sensitivity, specificity, and positive and negative predictive values of contrast-enhanced time-resolved MRA relative to DSA for posttreatment aneurysm occlusion were 96%, 85%, 92%, and 92%. Contrast-enhanced time-resolved MRA demonstrated superior quality of visualization (P = .0001) and a higher measurable luminal diameter (P = .0001) of the reconstructed artery compared with 3D-TOF MRA but no significant difference compared with DSA. Contrast-enhanced time-resolved MRA underestimated the luminal diameter of the reconstructed artery by 0.965 ± 0.497 mm (27% ± 13%) relative to DSA. Contrast-enhanced time-resolved MRA is a reliable noninvasive method for monitoring intracranial aneurysms following flow diversion and vessel reconstruction by using the Pipeline Embolization Device. © 2014 by American Journal of Neuroradiology.

Cooling of superconducting devices by liquid storage and refrigeration unit

DOEpatents

Laskaris, Evangelos Trifon; Urbahn, John Arthur; Steinbach, Albert Eugene

2013-08-20

A system is disclosed for cooling superconducting devices. The system includes a cryogen cooling system configured to be coupled to the superconducting device and to supply cryogen to the device. The system also includes a cryogen storage system configured to supply cryogen to the device. The system further includes flow control valving configured to selectively isolate the cryogen cooling system from the device, thereby directing a flow of cryogen to the device from the cryogen storage system.

Subscale Ship Airwake Studies Using Novel Vortex Flow Devices with Smoke, Laser-Vapor-Screen and Particle Image Velocimetry

NASA Technical Reports Server (NTRS)

Lamar, John E.; Landman, Drew; Swift, Russell S.; Parikh, Paresh C.

2007-01-01

Ships produce vortices and air-wakes while either underway or stationary in a wind. These flow fields can be detrimental to the conduction of air operations in that they can adversely impact the air vehicles and flight crews. There are potential solutions to these problems for both frigates/destroyers and carriers through the use of novel vortex flow or flow control devices. This appendix highlights several devices which may have application and points out that traditional wind-tunnel testing using smoke, laser-vapor screen, and Particle Image Velocimetry can be useful in sorting out the effectiveness of different devices.

Eye wash water flow direction study: an evaluation of the effectiveness of eye wash devices with opposite directional water flow.

PubMed

Fogt, Jennifer S; Jones-Jordan, Lisa A; Barr, Joseph T

2018-01-01

New designs of eye wash stations have been developed in which the direction of water flow from the fountain has been reversed, with two water streams originating nasally in both eyes and flowing toward the temporal side of each eye. No study has been done to determine the ideal direction of water flow coming from the eye wash in relation to the eye. Ophthalmic eye examinations were conducted before and after the use of two eye wash stations with opposite water flow directionality. Fluorescein was instilled in both eyes before using an eye wash to measure the effectiveness of the water flow. Subjects were surveyed upon their experiences using the eye washes. Ophthalmic examination found no significant difference in the efficacy of the eye washes with nasal-to-temporal water flow when compared to temporal-to-nasal water flow direction.

Elastic instability in stratified core annular flow.

PubMed

Bonhomme, Oriane; Morozov, Alexander; Leng, Jacques; Colin, Annie

2011-06-01

We study experimentally the interfacial instability between a layer of dilute polymer solution and water flowing in a thin capillary. The use of microfluidic devices allows us to observe and quantify in great detail the features of the flow. At low velocities, the flow takes the form of a straight jet, while at high velocities, steady or advected wavy jets are produced. We demonstrate that the transition between these flow regimes is purely elastic--it is caused by the viscoelasticity of the polymer solution only. The linear stability analysis of the flow in the short-wave approximation supplemented with a kinematic criterion captures quantitatively the flow diagram. Surprisingly, unstable flows are observed for strong velocities, whereas convected flows are observed for low velocities. We demonstrate that this instability can be used to measure the rheological properties of dilute polymer solutions that are difficult to assess otherwise.

Application of a Line Laser Scanner for Bed Form Tracking in a Laboratory Flume

NASA Astrophysics Data System (ADS)

de Ruijsscher, T. V.; Hoitink, A. J. F.; Dinnissen, S.; Vermeulen, B.; Hazenberg, P.

2018-03-01

A new measurement method for continuous detection of bed forms in movable bed laboratory experiments is presented and tested. The device consists of a line laser coupled to a 3-D camera, which makes use of triangulation. This allows to measure bed forms during morphodynamic experiments, without removing the water from the flume. A correction is applied for the effect of laser refraction at the air-water interface. We conclude that the absolute measurement error increases with increasing flow velocity, its standard deviation increases with water depth and flow velocity, and the percentage of missing values increases with water depth. Although 71% of the data is lost in a pilot moving bed experiment with sand, still high agreement between flowing water and dry bed measurements is found when a robust LOcally weighted regrESSion (LOESS) procedure is applied. This is promising for bed form tracking applications in laboratory experiments, especially when lightweight sediments like polystyrene are used, which require smaller flow velocities to achieve dynamic similarity to the prototype. This is confirmed in a moving bed experiment with polystyrene.

Retrieving accurate temporal and spatial information about Taylor slug flows from non-invasive NIR photometry measurements

NASA Astrophysics Data System (ADS)

Helmers, Thorben; Thöming, Jorg; Mießner, Ulrich

2017-11-01

In this article, we introduce a novel approach to retrieve spatial- and time-resolved Taylor slug flow information from a single non-invasive photometric flow sensor. The presented approach uses disperse phase surface properties to retrieve the instantaneous velocity information from a single sensor's time-scaled signal. For this purpose, a photometric sensor system is simulated using a ray-tracing algorithm to calculate spatially resolved near-infrared transmission signals. At the signal position corresponding to the rear droplet cap, a correlation factor of the droplet's geometric properties is retrieved and used to extract the instantaneous droplet velocity from the real sensor's temporal transmission signal. Furthermore, a correlation for the rear cap geometry based on the a priori known total superficial flow velocity is developed, because the cap curvature is velocity sensitive itself. Our model for velocity derivation is validated, and measurements of a first prototype showcase the capability of the device. Long-term measurements visualize systematic fluctuations in droplet lengths, velocities, and frequencies that could otherwise, without the observation on a larger timescale, have been identified as measurement errors and not systematic phenomenas.

Development and evaluation of virtual refrigerant mass flow sensors for fault detection and diagnostics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, Woohyun; Braun, J.

Refrigerant mass flow rate is an important measurement for monitoring equipment performance and enabling fault detection and diagnostics. However, a traditional mass flow meter is expensive to purchase and install. A virtual refrigerant mass flow sensor (VRMF) uses a mathematical model to estimate flow rate using low-cost measurements and can potentially be implemented at low cost. This study evaluates three VRMFs for estimating refrigerant mass flow rate. The first model uses a compressor map that relates refrigerant flow rate to measurements of inlet and outlet pressure, and inlet temperature measurements. The second model uses an energy-balance method on the compressormore » that uses a compressor map for power consumption, which is relatively independent of compressor faults that influence mass flow rate. The third model is developed using an empirical correlation for an electronic expansion valve (EEV) based on an orifice equation. The three VRMFs are shown to work well in estimating refrigerant mass flow rate for various systems under fault-free conditions with less than 5% RMS error. Each of the three mass flow rate estimates can be utilized to diagnose and track the following faults: 1) loss of compressor performance, 2) fouled condenser or evaporator filter, 3) faulty expansion device, respectively. For example, a compressor refrigerant flow map model only provides an accurate estimation when the compressor operates normally. When a compressor is not delivering the expected flow due to a leaky suction or discharge valve or other internal fault, the energy-balance or EEV model can provide accurate flow estimates. In this paper, the flow differences provide an indication of loss of compressor performance and can be used for fault detection and diagnostics.« less

Highway-runoff quality, and treatment efficiencies of a hydrodynamic-settling device and a stormwater-filtration device in Milwaukee, Wisconsin

USGS Publications Warehouse

Horwatich, Judy A.; Bannerman, Roger T.; Pearson, Robert

2011-01-01

The treatment efficiencies of two prefabricated stormwater-treatment devices were tested at a freeway site in a high-density urban part of Milwaukee, Wisconsin. One treatment device is categorized as a hydrodynamic-settling device (HSD), which removes pollutants by sedimentation and flotation. The other treatment device is categorized as a stormwater-filtration device (SFD), which removes pollutants by filtration and sedimentation. During runoff events, flow measurements were recorded and water-quality samples were collected at the inlet and outlet of each device. Efficiency-ratio and summation-of-load (SOL) calculations were used to estimate the treatment efficiency of each device. Event-mean concentrations and loads that were decreased by passing through the HSD include total suspended solids (TSS), suspended sediment (SS), total phosphorus (TP), total copper (TCu), and total zinc (TZn). The efficiency ratios for these constituents were 42, 57, 17, 33, and 23 percent, respectively. The SOL removal rates for these constituents were 25, 49, 10, 27, and 16 percent, respectively. Event-mean concentrations and loads that increased by passing through the HSD include chloride (Cl), total dissolved solids (TDS), and dissolved zinc (DZn). The efficiency ratios for these constituents were -347, -177, and 20 percent, respectively. Four constituents—dissolved phosphorus (DP), chemical oxygen demand (COD), total polycyclic aromatic hydrocarbon (PAH), and dissolved copper (DCu)—are not included in the list of computed efficiency ratio and SOL because the variability between sampled inlet and outlet pairs were not significantly different. Event-mean concentrations and loads that decreased by passing through the SFD include TSS, SS, TP, DCu, TCu, DZn, TZn, and COD. The efficiency ratios for these constituents were 59, 90, 40, 21, 66, 23, 66, and 18, respectively. The SOLs for these constituents were 50, 89, 37, 19, 60, 20, 65, and 21, respectively. Two constituents—DP and PAH—are not included in the lists of computed efficiency ratio and SOL because the variability between sampled inlet and outlet pairs were not significantly different. Similar to the HSD, the average efficiency ratios and SOLs for TDS and Cl were negative. Flow rates, high concentrations of SS, and particle-size distributions (PSD) can affect the treatment efficacies of the two devices. Flow rates equal to or greater than the design flow rate of the HSD had minimal or negative removal efficiencies for TSS and SS loads. Similar TSS removal efficiencies were observed at the SFD, but SS was consistently removed throughout the flow regime. Removal efficiencies were high for both devices when concentrations of SS and TSS approached 200 mg/L. A small number of runoff events were analyzed for PSD; the average sand content at the HSD was 33 percent and at the SFD was 71 percent. The 71-percent sand content may reflect the 90-percent removal efficiency of SS at the SFD. Particles retained at the bottom of both devices were largely sand-size or greater.

Introduction to Instrumentation. Teacher Edition.

ERIC Educational Resources Information Center

Brown, A. O., III

This module contains instructional materials on instrumentation to help teachers train students in the job skills they will need as beginning instrumentation technicians. The module addresses the nature of accessing, measuring, and controlling phenomena such as level, flow, pressure, and temperature. Students are introduced to the devices and…

Towards Explaining the Water Siphon

ERIC Educational Resources Information Center

Jumper, William D.; Stanchev, Boris

2014-01-01

Many high school and introductory college physics courses cover topics in fluidics through the Bernoulli and Poiseuille equations, and consequently one might think that siphons should present an excellent opportunity to engage students in various laboratory measurement exercises incorporating these fascinating devices. However, the flow rates (or…