Design and Uncertainty Analysis for a PVTt Gas Flow Standard

PubMed Central

Wright, John D.; Johnson, Aaron N.; Moldover, Michael R.

2003-01-01

A new pressure, volume, temperature, and, time (PVTt) primary gas flow standard at the National Institute of Standards and Technology has an expanded uncertainty (k = 2) of between 0.02 % and 0.05 %. The standard spans the flow range of 1 L/min to 2000 L/min using two collection tanks and two diverter valve systems. The standard measures flow by collecting gas in a tank of known volume during a measured time interval. We describe the significant and novel features of the standard and analyze its uncertainty. The gas collection tanks have a small diameter and are immersed in a uniform, stable, thermostatted water bath. The collected gas achieves thermal equilibrium rapidly and the uncertainty of the average gas temperature is only 7 mK (22 × 10−6 T). A novel operating method leads to essentially zero mass change in and very low uncertainty contributions from the inventory volume. Gravimetric and volume expansion techniques were used to determine the tank and the inventory volumes. Gravimetric determinations of collection tank volume made with nitrogen and argon agree with a standard deviation of 16 × 10−6 VT. The largest source of uncertainty in the flow measurement is drift of the pressure sensor over time, which contributes relative standard uncertainty of 60 × 10−6 to the determinations of the volumes of the collection tanks and to the flow measurements. Throughout the range 3 L/min to 110 L/min, flows were measured independently using the 34 L and the 677 L collection systems, and the two systems agreed within a relative difference of 150 × 10−6. Double diversions were used to evaluate the 677 L system over a range of 300 L/min to 1600 L/min, and the relative differences between single and double diversions were less than 75 × 10−6. PMID:27413592

In Vivo Validation of Volume Flow Measurements of Pulsatile Flow Using a Clinical Ultrasound System and Matrix Array Transducer.

PubMed

Hudson, John M; Williams, Ross; Milot, Laurent; Wei, Qifeng; Jago, James; Burns, Peter N

2017-03-01

The goal of this study was to evaluate the accuracy of a non-invasive C-plane Doppler estimation of pulsatile blood flow in the lower abdominal vessels of a porcine model. Doppler ultrasound measurements from a matrix array transducer system were compared with invasive volume flow measurements made on the same vessels with a surgically implanted ultrasonic transit-time flow probe. For volume flow rates ranging from 60 to 750 mL/min, agreement was very good, with a Pearson correlation coefficient of 0.97 (p < 0.0001) and a mean bias of -4.2%. The combination of 2-D matrix array technology and fast processing gives this Doppler method clinical potential, as many of the user- and system-dependent parameters of previous methods, including explicit vessel angle and diameter measurements, are eliminated. Copyright © 2016 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.

A computer system for analysis and transmission of spirometry waveforms using volume sampling.

PubMed

Ostler, D V; Gardner, R M; Crapo, R O

1984-06-01

A microprocessor-controlled data gathering system for telemetry and analysis of spirometry waveforms was implemented using a completely digital design. Spirometry waveforms were obtained from an optical shaft encoder attached to a rolling seal spirometer. Time intervals between 10-ml volume changes (volume sampling) were stored. The digital design eliminated problems of analog signal sampling. The system measured flows up to 12 liters/sec with 5% accuracy and volumes up to 10 liters with 1% accuracy. Transmission of 10 waveforms took about 3 min. Error detection assured that no data were lost or distorted during transmission. A pulmonary physician at the central hospital reviewed the volume-time and flow-volume waveforms and interpretations generated by the central computer before forwarding the results and consulting with the rural physician. This system is suitable for use in a major hospital, rural hospital, or small clinic because of the system's simplicity and small size.

A Second Law Based Unstructured Finite Volume Procedure for Generalized Flow Simulation

NASA Technical Reports Server (NTRS)

Majumdar, Alok

1998-01-01

An unstructured finite volume procedure has been developed for steady and transient thermo-fluid dynamic analysis of fluid systems and components. The procedure is applicable for a flow network consisting of pipes and various fittings where flow is assumed to be one dimensional. It can also be used to simulate flow in a component by modeling a multi-dimensional flow using the same numerical scheme. The flow domain is discretized into a number of interconnected control volumes located arbitrarily in space. The conservation equations for each control volume account for the transport of mass, momentum and entropy from the neighboring control volumes. In addition, they also include the sources of each conserved variable and time dependent terms. The source term of entropy equation contains entropy generation due to heat transfer and fluid friction. Thermodynamic properties are computed from the equation of state of a real fluid. The system of equations is solved by a hybrid numerical method which is a combination of simultaneous Newton-Raphson and successive substitution schemes. The paper also describes the application and verification of the procedure by comparing its predictions with the analytical and numerical solution of several benchmark problems.

Two-Dimensional Automatic Measurement for Nozzle Flow Distribution Using Improved Ultrasonic Sensor

PubMed Central

Zhai, Changyuan; Zhao, Chunjiang; Wang, Xiu; Wang, Ning; Zou, Wei; Li, Wei

2015-01-01

Spray deposition and distribution are affected by many factors, one of which is nozzle flow distribution. A two-dimensional automatic measurement system, which consisted of a conveying unit, a system control unit, an ultrasonic sensor, and a deposition collecting dish, was designed and developed. The system could precisely move an ultrasonic sensor above a pesticide deposition collecting dish to measure the nozzle flow distribution. A sensor sleeve with a PVC tube was designed for the ultrasonic sensor to limit its beam angle in order to measure the liquid level in the small troughs. System performance tests were conducted to verify the designed functions and measurement accuracy. A commercial spray nozzle was also used to measure its flow distribution. The test results showed that the relative error on volume measurement was less than 7.27% when the liquid volume was 2 mL in trough, while the error was less than 4.52% when the liquid volume was 4 mL or more. The developed system was also used to evaluate the flow distribution of a commercial nozzle. It was able to provide the shape and the spraying width of the flow distribution accurately. PMID:26501288

Estimating the system price of redox flow batteries for grid storage

NASA Astrophysics Data System (ADS)

Ha, Seungbum; Gallagher, Kevin G.

2015-11-01

Low-cost energy storage systems are required to support extensive deployment of intermittent renewable energy on the electricity grid. Redox flow batteries have potential advantages to meet the stringent cost target for grid applications as compared to more traditional batteries based on an enclosed architecture. However, the manufacturing process and therefore potential high-volume production price of redox flow batteries is largely unquantified. We present a comprehensive assessment of a prospective production process for aqueous all vanadium flow battery and nonaqueous lithium polysulfide flow battery. The estimated investment and variable costs are translated to fixed expenses, profit, and warranty as a function of production volume. When compared to lithium-ion batteries, redox flow batteries are estimated to exhibit lower costs of manufacture, here calculated as the unit price less materials costs, owing to their simpler reactor (cell) design, lower required area, and thus simpler manufacturing process. Redox flow batteries are also projected to achieve the majority of manufacturing scale benefits at lower production volumes as compared to lithium-ion. However, this advantage is offset due to the dramatically lower present production volume of flow batteries compared to competitive technologies such as lithium-ion.

40 CFR 60.73a - Emissions testing and monitoring.

Code of Federal Regulations, 2013 CFR

2013-07-01

... system (e.g., weigh scale, volume flow meter, mass flow meter, tank volume) to measure and record the... via titration or by determining the temperature and specific gravity of the nitric acid. You may also...

40 CFR 60.73a - Emissions testing and monitoring.

Code of Federal Regulations, 2014 CFR

2014-07-01

... system (e.g., weigh scale, volume flow meter, mass flow meter, tank volume) to measure and record the... via titration or by determining the temperature and specific gravity of the nitric acid. You may also...

Methodology update for estimating volume to service flow ratio.

DOT National Transportation Integrated Search

2015-12-01

Volume/service flow ratio (VSF) is calculated by the Highway Performance Monitoring System (HPMS) software as an indicator of peak hour congestion. It is an essential input to the Kentucky Transportation Cabinets (KYTC) key planning applications, ...

Preventing Molecular and Particulate Infiltration in a Confined Volume

NASA Technical Reports Server (NTRS)

Scialdone, John J.

1999-01-01

Contaminants from an instrument's self-generated sources or from sources external to the instrument may degrade its critical surfaces and/or create an environment which limits the instrument's intended performance. Analyses have been carried out on a method to investigate the required purging flow of clean, dry gas to prevent the ingestion of external contaminants into the instrument container volume. The pressure to be maintained and the required flow are examined in terms of their effectiveness in preventing gaseous and particulate contaminant ingestion and abatement of self-generated contaminants in the volume. The required venting area or the existing volume venting area is correlated to the volume to be purged, the allowable pressure differential across the volume, the external contaminant partial pressure, and the sizes of the ambient particulates. The diffusion of external water vapor into the volume while it was being purged was experimentally obtained in terms of an infiltration time constant. That data and the acceptable fraction of the outside pressure into the volume indicate the required flow of purge gas expressed in terms of volume change per unit time. The exclusion of particulates is based on the incoming velocity of the particles and the exit flow speed and density of the purge gas. The purging flow pressures needed to maintain the required flows through the vent passages are indicated. The purge gas must prevent or limit the entrance of the external contaminants to the critical locations of the instrument. It should also prevent self- contamination from surfaces, reduce material outgassing, and sweep out the outgassed products. Systems and facilities that can benefit from purging may be optical equipment, clinical facilities, manufacturing facilities, clean rooms, and other systems requiring clean environments.

A mass-balanced definition of corrected retention volume in gas chromatography.

PubMed

Kurganov, A

2007-05-25

The mass balance equation of a chromatographic system using a compressible moving phase has been compiled for mass flow of the mobile phase instead of traditional volumetric flow allowing solution of the equation in an analytical form. The relation obtained correlates retention volume measured under ambient conditions with the partition coefficient of the solute. Compared to the relation in the ideal chromatographic system the equation derived contains an additional correction term accounting for the compressibility of the moving phase. When the retention volume is measured under the mean column pressure and column temperature the correction term is reduced to unit and the relation is simplified to those known for the ideal system. This volume according to International Union of Pure and Applied Chemistry (IUPAC) is called the corrected retention volume.

The application of improved flow diverter for first flush management.

PubMed

Mrowiec, M

2010-01-01

The paper presents the investigations on first flush phenomenon based on the total suspended solids (TSS) concentration measurement during selected rainfalls at central part of Czestochowa (Poland) and also the hydrodynamic model of the catchment. The model allows to present the conception of first flush management using an improved flow diverter Septurn. Flow diverters used in the separate sewer systems create a hybrid system called "semi-separate" sewage system, which allows to treat the first flush volume in the waste water treatment plant (WWTP). Proposed construction of the flow diverter makes possible to capture significant part of the pollutant load (TSS) and simultaneously to reduce volume discharges to WWTPs during wet weather.

Flight Design System-1 System Design Document. Volume 9: Executive logic flow, program design language

NASA Technical Reports Server (NTRS)

1979-01-01

The detailed logic flow for the Flight Design System Executive is presented. The system is designed to provide the hardware/software capability required for operational support of shuttle flight planning.

Shear-induced structural transitions in Newtonian non-Newtonian two-phase flow

NASA Astrophysics Data System (ADS)

Cristobal, G.; Rouch, J.; Colin, A.; Panizza, P.

2000-09-01

We show the existence under shear flow of steady states in a two-phase region of a brine-surfactant system in which lyotropic dilute lamellar (non-Newtonian) and sponge (Newtonian) phases are coexisting. At high shear rates and low sponge phase-volume fractions, we report on the existence of a dynamic transition corresponding to the formation of a colloidal crystal of multilamellar vesicles (or ``onions'') immersed in the sponge matrix. As the sponge phase-volume fraction increases, this transition exhibits a hysteresis loop leading to a structural bistability of the two-phase flow. Contrary to single phase lamellar systems where it is always 100%, the onion volume fraction can be monitored continuously from 0 to 100 %.

New York State Educational Information System (NYSEIS) Systems Design. Volume I, Phase II. Final Report.

ERIC Educational Resources Information Center

Price Waterhouse and Co., New York, NY.

This volume on Phase II of the New York State Educational Information System (NYSEIS) describes the Gross Systems Analysis and Design, which includes the general flow diagram and processing chart for each of the student, personnel, and financial subsystems. Volume II, Functional Specifications, includes input/output requirements and file…

ASDIR-II. Volume II. Program Description

DTIC Science & Technology

1975-01-01

in ASDIR. INPUT: Engine description, gas properties and case definition (See ASDIR-II, Volume I, User’s Manual). OIWPUT: Primarily the information...conditions Special surface cooling flow conditions Exhaust system surface properties The predictions provided by the progi un for the combination of a...nonattenuated by the atmosphere Optional exhaust system information which can be requested from the program is: Internal fluid flow properties Surface

Precise nanoliter fluid handling system with integrated high-speed flow sensor.

PubMed

Haber, Carsten; Boillat, Marc; van der Schoot, Bart

2005-04-01

A system for accurate low-volume delivery of liquids in the micro- to nanoliter range makes use of an integrated miniature flow sensor as part of an intelligent feedback control loop driving a micro-solenoid valve. The flow sensor is hydraulically connected with the pressurized system liquid in the dispensing channel and located downstream from the pressure source, above the solenoid valve. The sensor operates in a differential mode and responds in real-time to the internal flow-pulse resulting from the brief opening interval of the solenoid valve leading to a rapid ejection of a fluid droplet. The integral of the flow-pulse delivered by the sensor is directly proportional to the volume of the ejected droplet from the nozzle. The quantitative information is utilized to provide active control of the effectively dispensed or aspirated volume by adjusting the solenoid valve accordingly. This process significantly enhances the precision of the fluid delivery. The system furthermore compensates automatically for any changes in the viscosity of the dispensed liquid. The data delivered by the flow sensor can be saved and backtracked in order to confirm and validate the aspiration and dispensing process in its entirety. The collected dispense information can be used for quality control assessments and automatically be made part of an electronic record.

Numerical Modeling of Cavitating Venturi: A Flow Control Element of Propulsion System

NASA Technical Reports Server (NTRS)

Majumdar, Alok; Saxon, Jeff (Technical Monitor)

2002-01-01

In a propulsion system, the propellant flow and mixture ratio could be controlled either by variable area flow control valves or by passive flow control elements such as cavitating venturies. Cavitating venturies maintain constant propellant flowrate for fixed inlet conditions (pressure and temperature) and wide range of outlet pressures, thereby maintain constant, engine thrust and mixture ratio. The flowrate through the venturi reaches a constant value and becomes independent of outlet pressure when the pressure at throat becomes equal to vapor pressure. In order to develop a numerical model of propulsion system, it is necessary to model cavitating venturies in propellant feed systems. This paper presents a finite volume model of flow network of a cavitating venturi. The venturi was discretized into a number of control volumes and mass, momentum and energy conservation equations in each control volume are simultaneously solved to calculate one-dimensional pressure, density, and flowrate and temperature distribution. The numerical model predicts cavitations at the throat when outlet pressure was gradually reduced. Once cavitation starts, with further reduction of downstream pressure, no change in flowrate is found. The numerical predictions have been compared with test data and empirical equation based on Bernoulli's equation.

Development of a high-resolution automatic digital (urine/electrolytes) flow volume and rate measurement system of miniature size

NASA Technical Reports Server (NTRS)

Liu, F. F.

1975-01-01

To aid in the quantitative analysis of man's physiological rhythms, a flowmeter to measure circadian patterns of electrolyte excretion during various environmental stresses was developed. One initial flowmeter was designed and fabricated, the sensor of which is the approximate size of a wristwatch. The detector section includes a special type of dielectric integrating type sensor which automatically controls, activates, and deactivates the flow sensor data output by determining the presence or absence of fluid flow in the system, including operation under zero-G conditions. The detector also provides qualitative data on the composition of the fluid. A compact electronic system was developed to indicate flow rate as well as total volume per release or the cumulative volume of several releases in digital/analog forms suitable for readout or telemetry. A suitable data readout instrument is also provided. Calibration and statistical analyses of the performance functions required of the flowmeter were also conducted.

Analysis and design of three dimensional supersonic nozzles. Volume 2: Numerical program for analysis of nozzle-exhaust flow fields

NASA Technical Reports Server (NTRS)

Kalben, P.

1972-01-01

The FORTRAN IV Program developed to analyze the flow field associated with scramjet exhaust systems is presented. The instructions for preparing input and interpreting output are described. The program analyzes steady three dimensional supersonic flow by the reference plane characteristic technique. The governing equations and numerical techniques employed are presented in Volume 1 of this report.

Integration of a Capacitive EIS Sensor into a FIA System for pH and Penicillin Determination

PubMed Central

Rolka, David; Poghossian, Arshak; Schöning, Michael J.

2004-01-01

A field-effect based capacitive EIS (electrolyte-insulator-semiconductor) sensor with a p-Si-SiO2-Ta2O5 structure has been successfully integrated into a commercial FIA (flow-injection analysis) system and system performances have been proven and optimised for pH and penicillin detection. A flow-through cell was designed taking into account the requirement of a variable internal volume (from 12 μl up to 48 μl) as well as an easy replacement of the EIS sensor. FIA parameters (sample volume, flow rate, distance between the injection valve and the EIS sensor) have been optimised in terms of high sensitivity and reproducibility as well as a minimum dispersion of the injected sample zone. An acceptable compromise between different FIA parameters has been found. For the cell design used in this study, best results have been achieved with a flow rate of 1.4 ml/min, distance between the injection valve and the EIS sensor of 6.5 cm, probe volume of 0.75 ml, cell internal volume of 12 μl. A sample throughput of at least 15 samples/h was typically obtained.

Systems and methods for separating a multiphase fluid

NASA Technical Reports Server (NTRS)

Weislogel, Mark M. (Inventor); Thomas, Evan A. (Inventor); Graf, John C. (Inventor)

2011-01-01

Apparatus and methods for separating a fluid are provided. The apparatus can include a separator and a collector having an internal volume defined at least in part by one or more surfaces narrowing toward a bottom portion of the volume. The separator can include an exit port oriented toward the bottom portion of the volume. The internal volume can receive a fluid expelled from the separator into a flow path in the collector and the flow path can include at least two directional transitions within the collector.

Long, paired A'A/Pahoehoe flows of Mauna Loa: Volcanological significance and insights they provide into volcano plumbing systems

NASA Technical Reports Server (NTRS)

Rowland, Scott K.; Walker, George P. L.

1987-01-01

The long lava flows of Mauna Loa, Hawaii have been cited as Earth's closed analogs to the large Martian flows. It is therefore important to understand the flow mechanics and characteristics of the Mauna Loa flows and to make use of these in an attempt to gain insights into Martian eruptive processes. Two fundamentally different kinds of long lava flows can be distinguished on Hawaiian volcanoes as in Martian flows. The two kinds may have identical initial viscosities, chemical compositions, flow lengths, and flow volumes, but their flow mechanisms and thermal energy budgets are radically different. One travels a distance set by the discharge rate as envisaged by Walker and Wadge, and the other travels a distance set mainly by the eruption duration and ground slope. In the Mauna Loa lavas, yield strength becomes an important flow morphology control only in the distal part of a'a lavas. The occurrence of paired flows on Mauna Loa yields insights into the internal plumbing systems of the volcano, and it is significant that all of the volume of the a'a flow must be stored in a magma chamber before eruption, while none of the volume of the pahoehoe needs to be so stored. Differentiation between the two kinds of flows on images of Martian volcanoes is possible and hence an improved understanding of these huge structures is acquired.

The 1984 Mauna Loa eruption and planetary geolgoy

NASA Technical Reports Server (NTRS)

Moore, Henry J.

1987-01-01

In planetary geology, lava flows on the Moon and Mars are commonly treated as relatively simple systems. Some of the complexities of actual lava flows are illustrated using the main flow system of the 1984 Mauna Loa eruption. The outline, brief narrative, and results given are based on a number of sources. The implications of the results to planetary geology are clear. Volume flow rates during an eruption depend, in part, on the volatile content of the lava. These differ from the volume flow rates calculated from post eruption flow dimensions and the duration of the eruption and from those using models that assume a constant density. Mass flow rates might be more appropriate because the masses of volatiles in lavas are usually small, but variable and sometimes unknown densities impose severe restrictions on mass estimates.

Traffic flow forecasting for intelligent transportation systems.

DOT National Transportation Integrated Search

1995-01-01

The capability to forecast traffic volume in an operational setting has been identified as a critical need for intelligent transportation systems (ITS). In particular, traffic volume forecasts will directly support proactive traffic control and accur...

[Efficacy of preoxygenation using tidal volume breathing: a comparison of Mapleson A, Bain's and Circle system].

PubMed

Arora, Suman; Gupta, Priyanka; Arya, Virender Kumar; Bhatia, Nidhi

Efficacy of preoxygenation depends upon inspired oxygen concentration, its flow rate, breathing system configuration and patient characteristics. We hypothesized that in actual clinical scenario, where breathing circuit is not primed with 100% oxygen, patients may need more time to achieve EtO 2 ≥90%, and this duration may be different among various breathing systems. We thus studied the efficacy of preoxygenation using unprimed Mapleson A, Bain's and Circle system with tidal volume breathing at oxygen flow rates of 5L.min -1 and 10L.min -1 . Patients were randomly allocated into one of the six groups, wherein they were preoxygenated using either Mapleson A, Bain's or Circle system at O 2 flow rate of either 5L.min -1 or 10L.min -1 . The primary outcome measure of our study was the time taken to achieve EtO 2 ≥90% at 5 and 10L.min -1 flow rates. At oxygen flow rate of 5L.min -1 , time to reach EtO 2 ≥90% was significantly longer with Bain's system (3.7±0.67min) than Mapleson A and Circle system (2.9±0.6, 3.3±0.97min, respectively). However at oxygen flow rate of 10L.min -1 this time was significantly shorter and comparable among all the three breathing systems (2.33±0.38min with Mapleson, 2.59±0.50min with Bain's and 2.60±0.47min with Circle system). With spontaneous normal tidal volume breathing at oxygen flow rate of 5L.min -1 , Mapleson A can optimally preoxygenate patients within 3min while Bain's and Circle system require more time. However at O 2 flow rate of 10L.min -1 all the three breathing systems are capable of optimally preoxygenating the patients in less than 3min. Copyright © 2017 Sociedade Brasileira de Anestesiologia. Publicado por Elsevier Editora Ltda. All rights reserved.

A microprocessor-controlled tracheal insufflation-assisted total liquid ventilation system.

PubMed

Parker, James Courtney; Sakla, Adel; Donovan, Francis M; Beam, David; Chekuri, Annu; Al-Khatib, Mohammad; Hamm, Charles R; Eyal, Fabien G

2009-09-01

A prototype time cycled, constant volume, closed circuit perfluorocarbon (PFC) total liquid ventilator system is described. The system utilizes microcontroller-driven display and master control boards, gear motor pumps, and three-way solenoid valves to direct flow. A constant tidal volume and functional residual capacity (FRC) are maintained with feedback control using end-expiratory and end-inspiratory stop-flow pressures. The system can also provide a unique continuous perfusion (bias flow, tracheal insufflation) through one lumen of a double-lumen endotracheal catheter to increase washout of dead space liquid. FRC and arterial blood gases were maintained during ventilation with Rimar 101 PFC over 2-3 h in normal piglets and piglets with simulated pulmonary edema induced by instillation of albumin solution. Addition of tracheal insufflation flow significantly improved the blood gases and enhanced clearance of instilled albumin solution during simulated edema.

Large volume flow-through scintillating detector

DOEpatents

Gritzo, Russ E.; Fowler, Malcolm M.

1995-01-01

A large volume flow through radiation detector for use in large air flow situations such as incinerator stacks or building air systems comprises a plurality of flat plates made of a scintillating material arranged parallel to the air flow. Each scintillating plate has a light guide attached which transfers light generated inside the scintillating plate to an associated photomultiplier tube. The output of the photomultiplier tubes are connected to electronics which can record any radiation and provide an alarm if appropriate for the application.

Infusion volume control and calculation using metronome and drop counter based intravenous infusion therapy helper.

PubMed

Park, Kyungnam; Lee, Jangyoung; Kim, Soo-Young; Kim, Jinwoo; Kim, Insoo; Choi, Seung Pill; Jeong, Sikyung; Hong, Sungyoup

2013-06-01

This study assessed the method of fluid infusion control using an IntraVenous Infusion Controller (IVIC). Four methods of infusion control (dial flow controller, IV set without correction, IV set with correction and IVIC correction) were used to measure the volume of each technique at two infusion rates. The infused fluid volume with a dial flow controller was significantly larger than other methods. The infused fluid volume was significantly smaller with an IV set without correction over time. Regarding the concordance correlation coefficient (CCC) of infused fluid volume in relation to a target volume, IVIC correction was shown to have the highest level of agreement. The flow rate measured in check mode showed a good agreement with the volume of collected fluid after passing through the IV system. Thus, an IVIC could assist in providing an accurate infusion control. © 2013 Wiley Publishing Asia Pty Ltd.

Modeling of Compressible Flow with Friction and Heat Transfer Using the Generalized Fluid System Simulation Program (GFSSP)

NASA Technical Reports Server (NTRS)

Bandyopadhyay, Alak; Majumdar, Alok

2007-01-01

The present paper describes the verification and validation of a quasi one-dimensional pressure based finite volume algorithm, implemented in Generalized Fluid System Simulation Program (GFSSP), for predicting compressible flow with friction, heat transfer and area change. The numerical predictions were compared with two classical solutions of compressible flow, i.e. Fanno and Rayleigh flow. Fanno flow provides an analytical solution of compressible flow in a long slender pipe where incoming subsonic flow can be choked due to friction. On the other hand, Raleigh flow provides analytical solution of frictionless compressible flow with heat transfer where incoming subsonic flow can be choked at the outlet boundary with heat addition to the control volume. Nonuniform grid distribution improves the accuracy of numerical prediction. A benchmark numerical solution of compressible flow in a converging-diverging nozzle with friction and heat transfer has been developed to verify GFSSP's numerical predictions. The numerical predictions compare favorably in all cases.

Packaged peristaltic micropump for controlled drug delivery application

NASA Astrophysics Data System (ADS)

Vinayakumar, K. B.; Nadiger, Girish; R. Shetty, Vikas; Dinesh, N. S.; Nayak, M. M.; Rajanna, K.

2017-01-01

Micropump technology has evolved significantly in the last two decades and is finding a variety of applications ranging from μTAS (micro Total Analysis System) to drug delivery. However, the application area of the micropump is limited owing to: simple pumping mechanism, ease of handling, controlled (microliter to milliliter) delivery, continuous delivery, and accuracy in flow rate. Here, the author presents the design, development, characterization, and precision flow controlling of a DC-motor driven peristaltic pump for controlled drug delivery application. All the micropump components were fabricated using the conventional fabrication technique. The volume flow variation of the pump has been characterized for different viscous fluids. The change in volume flow due to change in back pressure has been presented in detail. The fail-safe mode operation of the pump has been tested and leak rate was measured (˜0.14% leak for an inlet pressure of 140 kPa) for different inlet pressures. The precision volume flow of the pump has been achieved by measuring the pinch cam position and load current. The accuracy in the volume flow has been measured after 300 rotations. Finally, the complete system has been integrated with the necessary electronics and an android application has been developed for the self-administration of bolus and basal delivery of insulin.

Parallel Computation and Visualization of Three-dimensional, Time-dependent, Thermal Convective Flows

NASA Technical Reports Server (NTRS)

Wang, P.; Li, P.

1998-01-01

A high-resolution numerical study on parallel systems is reported on three-dimensional, time-dependent, thermal convective flows. A parallel implentation on the finite volume method with a multigrid scheme is discussed, and a parallel visualization systemm is developed on distributed systems for visualizing the flow.

Apparatus for passive removal of subsurface contaminants and volume flow measurement

DOEpatents

Jackson, Dennis G.; Rossabi, Joseph; Riha, Brian D.

2002-01-01

A system for improving the Baroball valve and a method for retrofitting an existing Baroball valve. This invention improves upon the Baroball valve by reshaping the interior chamber of the valve to form a flow meter measuring chamber. The Baroball valve sealing mechanism acts as a rotameter bob for determining volume flow rate through the Baroball valve. A method for retrofitting a Baroball valve includes providing static pressure ports and connecting a measuring device, to these ports, for measuring the pressure differential between the Baroball chamber and the well. A standard curve of nominal device measurements allows the volume flow rate to be determined through the retrofitted Baroball valve.

Flow rate measurement in a volume

DOE Office of Scientific and Technical Information (OSTI.GOV)

Galvez, Cristhian

A system for measuring flow rate within a volume includes one or more transmission devices that transmit one or more signals through fluid contained within the volume. The volume may be bounded, at least in part, by an outer structure and by an object at least partially contained within the outer structure. A transmission device located at a first location of the outer structure transmits a first signal to a second location of the outer structure. A second signal is transmitted through the fluid from the second location to a third location of the outer structure. The flow rate ofmore » the fluid within the volume may be determined based, at least in part, on the time of flight of both the first signal and the second signal.« less

Water-vapor pressure control in a volume

NASA Technical Reports Server (NTRS)

Scialdone, J. J.

1978-01-01

The variation with time of the partial pressure of water in a volume that has openings to the outside environment and includes vapor sources was evaluated as a function of the purging flow and its vapor content. Experimental tests to estimate the diffusion of ambient humidity through openings and to validate calculated results were included. The purging flows required to produce and maintain a certain humidity in shipping containers, storage rooms, and clean rooms can be estimated with the relationship developed here. These purging flows are necessary to prevent the contamination, degradation, and other effects of water vapor on the systems inside these volumes.

Quantifying radar-rainfall uncertainties in urban drainage flow modelling

NASA Astrophysics Data System (ADS)

Rico-Ramirez, M. A.; Liguori, S.; Schellart, A. N. A.

2015-09-01

This work presents the results of the implementation of a probabilistic system to model the uncertainty associated to radar rainfall (RR) estimates and the way this uncertainty propagates through the sewer system of an urban area located in the North of England. The spatial and temporal correlations of the RR errors as well as the error covariance matrix were computed to build a RR error model able to generate RR ensembles that reproduce the uncertainty associated with the measured rainfall. The results showed that the RR ensembles provide important information about the uncertainty in the rainfall measurement that can be propagated in the urban sewer system. The results showed that the measured flow peaks and flow volumes are often bounded within the uncertainty area produced by the RR ensembles. In 55% of the simulated events, the uncertainties in RR measurements can explain the uncertainties observed in the simulated flow volumes. However, there are also some events where the RR uncertainty cannot explain the whole uncertainty observed in the simulated flow volumes indicating that there are additional sources of uncertainty that must be considered such as the uncertainty in the urban drainage model structure, the uncertainty in the urban drainage model calibrated parameters, and the uncertainty in the measured sewer flows.

Quantification of gastric emptying and duodenogastric reflux stroke volumes using three-dimensional guided digital color Doppler imaging.

PubMed

Hausken, T; Li, X N; Goldman, B; Leotta, D; Ødegaard, S; Martin, R W

2001-07-01

To develop a non-invasive method for evaluating gastric emptying and duodenogastric reflux stroke volumes using three-dimensional (3D) guided digital color Doppler imaging. The technique involved color Doppler digital images of transpyloric flow in which the 3D position and orientation of the images were known by using a magnetic location system. In vitro, the system was found to slightly underestimate the reference flow (by average 8.8%). In vivo (five volunteers), stroke volume of gastric emptying episodes lasted on average only 0.69 s with a volume on average of 4.3 ml (range 1.1-7.4 ml), and duodenogastric reflux episodes on average 1.4 s with a volume of 8.3 ml (range 1.3-14.1 ml). With the appropriate instrument settings, orientation determined color Doppler can be used for stroke volume quantification of gastric emptying and duodenogastric reflux episodes.

Respiration and the watershed of spinal CSF flow in humans.

PubMed

Dreha-Kulaczewski, Steffi; Konopka, Mareen; Joseph, Arun A; Kollmeier, Jost; Merboldt, Klaus-Dietmar; Ludwig, Hans-Christoph; Gärtner, Jutta; Frahm, Jens

2018-04-04

The dynamics of human CSF in brain and upper spinal canal are regulated by inspiration and connected to the venous system through associated pressure changes. Upward CSF flow into the head during inspiration counterbalances venous flow out of the brain. Here, we investigated CSF motion along the spinal canal by real-time phase-contrast flow MRI at high spatial and temporal resolution. Results reveal a watershed of spinal CSF dynamics which divides flow behavior at about the level of the heart. While forced inspiration prompts upward surge of CSF flow volumes in the entire spinal canal, ensuing expiration leads to pronounced downward CSF flow, but only in the lower canal. The resulting pattern of net flow volumes during forced respiration yields upward CSF motion in the upper and downward flow in the lower spinal canal. These observations most likely reflect closely coupled CSF and venous systems as both large caval veins and their anastomosing vertebral plexus react to respiration-induced pressure changes.

FLOW-i ventilator performance in the presence of a circle system leak.

PubMed

Lucangelo, Umberto; Ajčević, Miloš; Accardo, Agostino; Borelli, Massimo; Peratoner, Alberto; Comuzzi, Lucia; Zin, Walter A

2017-04-01

Recently, the FLOW-i anaesthesia ventilator was developed based on the SERVO-i intensive care ventilator. The aim of this study was to test the FLOW-i's tidal volume delivery in the presence of a leak in the breathing circuit. We ventilated a test lung model in volume-, pressure-, and pressure-regulated volume-controlled modes (VC, PC, and PRVC, respectively) with a FLOW-i. First, the circuit remained airtight and the ventilator was tested with fresh gas flows of 6, 1, and 0.3 L/min in VC, PC, and PRVC modes and facing 4 combinations of different resistive and elastic loads. Second, a fixed leak in the breathing circuit was introduced and the measurements repeated. In the airtight system, FLOW-i maintained tidal volume (VT) and circuit pressure at approximately the set values, independently of respiratory mode, load, or fresh gas flow. In the leaking circuit, set VT = 500 mL, FLOW-i delivered higher VTs in PC (about 460 mL) than in VC and PRVC, where VTs were substantially less than 500 mL. Interestingly, VT did not differ appreciably from 6 to 0.3 L/min of fresh air flow among the 3 ventilatory modes. In the absence of leakage, peak inspiratory pressures were similar, while they were 35-45 % smaller in PRVC and VC than in PC mode in the presence of leaks. In conclusion, FLOW-i maintained VT (down to fresh gas flows of 0.3 L/min) to 90 % of its preset value in PC mode, which was 4-5 times greater than in VC or PRVC modes.

Assessment of volume and leak measurements during CPAP using a neonatal lung model.

PubMed

Fischer, H S; Roehr, C C; Proquitté, H; Wauer, R R; Schmalisch, G

2008-01-01

Although several commercial devices are available which allow tidal volume and air leak monitoring during continuous positive airway pressure (CPAP) in neonates, little is known about their measurement accuracy and about the influence of air leaks on volume measurement. The aim of this in vitro study was the validation of volume and leak measurement under CPAP using a commercial ventilatory device, taking into consideration the clinical conditions in neonatology. The measurement accuracy of the Leoni ventilator (Heinen & Löwenstein, Germany) was investigated both in a leak-free system and with leaks simulated using calibration syringes (2-10 ml, 20-100 ml) and a mechanical lung model. Open tubes of variable lengths were connected for leak simulation. Leak flow was measured with the flow-through technique. In a leak-free system the mean relative volume error +/-SD was 3.5 +/- 2.6% (2-10 ml) and 5.9 +/- 0.7% (20-60 ml), respectively. The influence of CPAP level, driving flow, respiratory rate and humidification of the breathing gas on the volume error was negligible. However, an increasing F(i)O(2) caused the measured tidal volume to increase by up to 25% (F(i)O(2) = 1.0). The relative error +/- SD of the leak measurements was -0.2 +/- 11.9%. For leaks > 19%, measured tidal volume was underestimated by more than 10%. In conclusion, the present in vitro study showed that the Leoni allowed accurate volume monitoring under CPAP conditions similar to neonates. Air leaks of up to 90% of patient flow were reliably detected. For an F(i)O(2) > 0.4 and for leaks > 19%, a numerical correction of the displayed volume should be performed.

Contained radiological analytical chemistry module

DOEpatents

Barney, David M.

1989-01-01

A system which provides analytical determination of a plurality of water chemistry parameters with respect to water samples subject to radiological contamination. The system includes a water sample analyzer disposed within a containment and comprising a sampling section for providing predetermined volumes of samples for analysis; a flow control section for controlling the flow through the system; and a gas analysis section for analyzing samples provided by the sampling system. The sampling section includes a controllable multiple port valve for, in one position, metering out sample of a predetermined volume and for, in a second position, delivering the material sample for analysis. The flow control section includes a regulator valve for reducing the pressure in a portion of the system to provide a low pressure region, and measurement devices located in the low pressure region for measuring sample parameters such as pH and conductivity, at low pressure. The gas analysis section which is of independent utility provides for isolating a small water sample and extracting the dissolved gases therefrom into a small expansion volume wherein the gas pressure and thermoconductivity of the extracted gas are measured.

Contained radiological analytical chemistry module

DOEpatents

Barney, David M.

1990-01-01

A system which provides analytical determination of a plurality of water chemistry parameters with respect to water samples subject to radiological contamination. The system includes a water sample analyzer disposed within a containment and comprising a sampling section for providing predetermined volumes of samples for analysis; a flow control section for controlling the flow through the system; and a gas analysis section for analyzing samples provided by the sampling system. The sampling section includes a controllable multiple port valve for, in one position, metering out sample of a predetermined volume and for, in a second position, delivering the material sample for analysis. The flow control section includes a regulator valve for reducing the pressure in a portion of the system to provide a low pressure region, and measurement devices located in the low pressure region for measuring sample parameters such as pH and conductivity, at low pressure. The gas analysis section which is of independent utility provides for isolating a small water sample and extracting the dissolved gases therefrom into a small expansion volume wherein the gas pressure and thermoconductivity of the extracted gas are measured.

[Identifying dry-weather flow and pollution load sources of separate storm sewer systems with different degrees of illicit discharge].

PubMed

Meng, Ying-ying; Feng, Cang; Li, Tian; Wang, Ling

2009-12-01

Dry-weather flow quantity and quality of three representative separate storm sewer systems in Shanghai-H, G, N were studied. Based on survey of operating status of the pumping stations as well as characteristics of the drainage systems, it was obtained that the interception sewage volumes per unit area in the three systems were 3610 m3/(km2 x d), 1550 m3/(km2 x d), 2970 m3/(km2 x d) respectively; the sanitary wastewater included accounted for 25%, 85% and 71% respectively; the interception volume of H was mainly composed of infiltrated underground water, so the dry-weather flow pollution was slighter, and the interception volumes of G, N were both mainly composed of sanitary wastewater, so the dry-weather which were flow pollution was relatively serious. The water characteristics of potential illicit discharge sources of dry-weather which were flow-grey water, black water and underground water were preliminarily explored, so that treating three parameters-LAS/ NH4+ -N, NH4+ -N/K, Mg/K as tracer parameters of grey water, black water and underground water was put forward. Moreover, the water characteristics of grey water and sanitary wastewater including black water were summarized: the feature of grey water was LAS/NH4+ -N > 0.2, NH4+ -N/K <1, and sanitary wastewater was LAS/NH4+ -N < 0.2, NH4+ -N/K >1. Based on the above, the applications of flow chart method and CMBM method in dry-weather flow detection of monitored storm systems were preliminarily discussed, and the results were basically same as that obtained in flow quantity and quality comprehensive analysis. The research results and methods can provide guidance for analysis and diagnosis of dry-weather flow sources and subsequent reconstruction projects in similar separate storm sewer systems at home.

A urine volume measurement system

NASA Technical Reports Server (NTRS)

Poppendiek, H. F.; Mouritzen, G.; Sabin, C. M.

1972-01-01

An improved urine volume measurement system for use in the unusual environment of manned space flight is reported. The system utilizes a low time-constant thermal flowmeter. The time integral of the transient response of the flowmeter gives the urine volume during a void as it occurs. In addition, the two phase flows through the flowmeter present no problem. Developments of the thermal flowmeter and a verification of the predicted performance characteristics are summarized.

Are there benefits or harm from pressure targeting during lung-protective ventilation?

PubMed

MacIntyre, Neil R; Sessler, Curtis N

2010-02-01

Mechanically, breath design is usually either flow/volume-targeted or pressure-targeted. Both approaches can effectively provide lung-protective ventilation, but they prioritize different ventilation parameters, so their responses to changing respiratory-system mechanics and patient effort are different. These different response behaviors have advantages and disadvantages that can be important in specific circumstances. Flow/volume targeting guarantees a set minute ventilation but sometimes may be difficult to synchronize with patient effort, and it will not limit inspiratory pressure. In contrast, pressure targeting, with its variable flow, may be easier to synchronize and will limit inspiratory pressure, but it provides no control over delivered volume. Skilled clinicians can maximize benefits and minimize problems with either flow/volume targeting or pressure targeting. Indeed, as is often the case in managing complex life-support devices, it is operator expertise rather than the device design features that most impacts patient outcomes.

Variable volume combustor with an air bypass system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johnson, Thomas Edward; Ziminsky, Willy Steve; Ostebee, Heath Michael

The present application provides a combustor for use with flow of fuel and a flow of air in a gas turbine engine. The combustor may include a number of micro-mixer fuel nozzles positioned within a liner and an air bypass system position about the liner. The air bypass system variably allows a bypass portion of the flow of air to bypass the micro-mixer fuel nozzles.

Gas Flow in the Capillary of the Atmosphere-to-Vacuum Interface of Mass Spectrometers

NASA Astrophysics Data System (ADS)

Skoblin, Michael; Chudinov, Alexey; Soulimenkov, Ilia; Brusov, Vladimir; Kozlovskiy, Viacheslav

2017-10-01

Numerical simulations of a gas flow through a capillary being a part of mass spectrometer atmospheric interface were performed using a detailed laminar flow model. The simulated interface consisted of atmospheric and forevacuum volumes connected via a thin capillary. The pressure in the forevacuum volume where the gas was expanding after passing through the capillary was varied in the wide range from 10 to 900 mbar in order to study the volume flow rate as well as the other flow parameters as functions of the pressure drop between the atmospheric and forevacuum volumes. The capillary wall temperature was varied in the range from 24 to 150 °C. Numerical integration of the complete system of Navier-Stokes equations for a viscous compressible gas taking into account the heat transfer was performed using the standard gas dynamic simulation software package ANSYS CFX. The simulation results were compared with experimental measurements of gas flow parameters both performed using our experimental setup and taken from the literature. The simulated volume flow rates through the capillary differed no more than by 10% from the measured ones over the entire pressure and temperatures ranges. A conclusion was drawn that the detailed digital laminar model is able to quantitatively describe the measured gas flow rates through the capillaries under conditions considered. [Figure not available: see fulltext.

Gas Flow in the Capillary of the Atmosphere-to-Vacuum Interface of Mass Spectrometers.

PubMed

Skoblin, Michael; Chudinov, Alexey; Soulimenkov, Ilia; Brusov, Vladimir; Kozlovskiy, Viacheslav

2017-10-01

Numerical simulations of a gas flow through a capillary being a part of mass spectrometer atmospheric interface were performed using a detailed laminar flow model. The simulated interface consisted of atmospheric and forevacuum volumes connected via a thin capillary. The pressure in the forevacuum volume where the gas was expanding after passing through the capillary was varied in the wide range from 10 to 900 mbar in order to study the volume flow rate as well as the other flow parameters as functions of the pressure drop between the atmospheric and forevacuum volumes. The capillary wall temperature was varied in the range from 24 to 150 °C. Numerical integration of the complete system of Navier-Stokes equations for a viscous compressible gas taking into account the heat transfer was performed using the standard gas dynamic simulation software package ANSYS CFX. The simulation results were compared with experimental measurements of gas flow parameters both performed using our experimental setup and taken from the literature. The simulated volume flow rates through the capillary differed no more than by 10% from the measured ones over the entire pressure and temperatures ranges. A conclusion was drawn that the detailed digital laminar model is able to quantitatively describe the measured gas flow rates through the capillaries under conditions considered. Graphical Abstract ᅟ.

A novel simulation theory and model system for multi-field coupling pipe-flow system

NASA Astrophysics Data System (ADS)

Chen, Yang; Jiang, Fan; Cai, Guobiao; Xu, Xu

2017-09-01

Due to the lack of a theoretical basis for multi-field coupling in many system-level models, a novel set of system-level basic equations for flow/heat transfer/combustion coupling is put forward. Then a finite volume model of quasi-1D transient flow field for multi-species compressible variable-cross-section pipe flow is established by discretising the basic equations on spatially staggered grids. Combining with the 2D axisymmetric model for pipe-wall temperature field and specific chemical reaction mechanisms, a finite volume model system is established; a set of specific calculation methods suitable for multi-field coupling system-level research is structured for various parameters in this model; specific modularisation simulation models can be further derived in accordance with specific structures of various typical components in a liquid propulsion system. This novel system can also be used to derive two sub-systems: a flow/heat transfer two-field coupling pipe-flow model system without chemical reaction and species diffusion; and a chemical equilibrium thermodynamic calculation-based multi-field coupling system. The applicability and accuracy of two sub-systems have been verified through a series of dynamic modelling and simulations in earlier studies. The validity of this system is verified in an air-hydrogen combustion sample system. The basic equations and the model system provide a unified universal theory and numerical system for modelling and simulation and even virtual testing of various pipeline systems.

A volume-filtered formulation to capture particle-shock interactions in multiphase compressible flows

NASA Astrophysics Data System (ADS)

Shallcross, Gregory; Capecelatro, Jesse

2017-11-01

Compressible particle-laden flows are common in engineering systems. Applications include but are not limited to water injection in high-speed jet flows for noise suppression, rocket-plume surface interactions during planetary landing, and explosions during coal mining operations. Numerically, it is challenging to capture these interactions due to the wide range of length and time scales. Additionally, there are many forms of the multiphase compressible flow equations with volume fraction effects, some of which are conflicting in nature. The purpose of this presentation is to develop the capability to accurately capture particle-shock interactions in systems with a large number of particles from dense to dilute regimes. A thorough derivation of the volume filtered equations is presented. The volume filtered equations are then implemented in a high-order, energy-stable Eulerian-Lagrangian framework. We show this framework is capable of decoupling the fluid mesh from the particle size, enabling arbitrary particle size distributions in the presence of shocks. The proposed method is then assessed against particle-laden shock tube data. Quantities of interest include fluid-phase pressure profiles and particle spreading rates. The effect of collisions in 2D and 3D are also evaluated.

A Hydrostatic Bearing Test System for Measuring Bearing Load Using Magnetic-Fluid Lubricants.

PubMed

Weng, Huei Chu; Chen, Lu-Yu

2016-05-01

This paper conducts a study on the design of a hydrostatic bearing test system. It involves the determination of viscous properties of magnetic-fluid lubricants. The load of a hydrostatic thrust bearing using a water-based magnetite nanofluid of varying volume flow rate is measured under an applied external induction field via the test system. Results reveal that the presence of nanoparticles in a carrier liquid would cause an enhanced bearing load. Such an effect could be further magnified by increasing the lubricant volume flow rate or the external induction field strength.

Hybrid energy storage systems utilizing redox active organic compounds

DOEpatents

Wang, Wei; Xu, Wu; Li, Liyu; Yang, Zhenguo

2015-09-08

Redox flow batteries (RFB) have attracted considerable interest due to their ability to store large amounts of power and energy. Non-aqueous energy storage systems that utilize at least some aspects of RFB systems are attractive because they can offer an expansion of the operating potential window, which can improve on the system energy and power densities. One example of such systems has a separator separating first and second electrodes. The first electrode includes a first current collector and volume containing a first active material. The second electrode includes a second current collector and volume containing a second active material. During operation, the first source provides a flow of first active material to the first volume. The first active material includes a redox active organic compound dissolved in a non-aqueous, liquid electrolyte and the second active material includes a redox active metal.

Development of a system for acquiring, reconstructing, and visualizing three-dimensional ultrasonic angiograms

NASA Astrophysics Data System (ADS)

Edwards, Warren S.; Ritchie, Cameron J.; Kim, Yongmin; Mack, Laurence A.

1995-04-01

We have developed a three-dimensional (3D) imaging system using power Doppler (PD) ultrasound (US). This system can be used for visualizing and analyzing the vascular anatomy of parenchymal organs. To create the 3D PD images, we acquired a series of two-dimensional PD images from a commercial US scanner and recorded the position and orientation of each image using a 3D magnetic position sensor. Three-dimensional volumes were reconstructed using specially designed software and then volume rendered for display. We assessed the feasibility and geometric accuracy of our system with various flow phantoms. The system was then tested on a volunteer by scanning a transplanted kidney. The reconstructed volumes of the flow phantom contained less than 1 mm of geometric distortion and the 3D images of the transplanted kidney depicted the segmental, arcuate, and interlobar vessels.

Cardiovascular function, compliance, and connective tissue remodeling in the turtle, Trachemys scripta, following thermal acclimation

PubMed Central

Keen, Adam N.; Crossley, Dane A.

2016-01-01

Low temperature directly alters cardiovascular physiology in freshwater turtles, causing bradycardia, arterial hypotension, and a reduction in systemic blood pressure. At the same time, blood viscosity and systemic resistance increase, as does sensitivity to cardiac preload (e.g., via the Frank-Starling response). However, the long-term effects of these seasonal responses on the cardiovascular system are unclear. We acclimated red-eared slider turtles to a control temperature (25°C) or to chronic cold (5°C). To differentiate the direct effects of temperature from a cold-induced remodeling response, all measurements were conducted at the control temperature (25°C). In anesthetized turtles, cold acclimation reduced systemic resistance by 1.8-fold and increased systemic blood flow by 1.4-fold, resulting in a 2.3-fold higher right to left (R-L; net systemic) cardiac shunt flow and a 1.8-fold greater shunt fraction. Following a volume load by bolus injection of saline (calculated to increase stroke volume by 5-fold, ∼2.2% of total blood volume), systemic resistance was reduced while pulmonary blood flow and systemic pressure increased. An increased systemic blood flow meant the R-L cardiac shunt was further pronounced. In the isolated ventricle, passive stiffness was increased following cold acclimation with 4.2-fold greater collagen deposition in the myocardium. Histological sections of the major outflow arteries revealed a 1.4-fold higher elastin content in cold-acclimated animals. These results suggest that cold acclimation alters cardiac shunting patterns with an increased R-L shunt flow, achieved through reducing systemic resistance and increasing systemic blood flow. Furthermore, our data suggests that cold-induced cardiac remodeling may reduce the stress of high cardiac preload by increasing compliance of the vasculature and decreasing compliance of the ventricle. Together, these responses could compensate for reduced systolic function at low temperatures in the slider turtle. PMID:27101300

Energy measurement using flow computers and chromatography

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beeson, J.

1995-12-01

Arkla Pipeline Group (APG), along with most transmission companies, went to electronic flow measurement (EFM) to: (1) Increase resolution and accuracy; (2) Real time correction of flow variables; (3) Increase speed in data retrieval; (4) Reduce capital expenditures; and (5) Reduce operation and maintenance expenditures Prior to EFM, mechanical seven day charts were used which yielded 800 pressure and differential pressure readings. EFM yields 1.2-million readings, a 1500 time improvement in resolution and additional flow representation. The total system accuracy of the EFM system is 0.25 % compared with 2 % for the chart system which gives APG improved accuracy.more » A typical APG electronic measurement system includes a microprocessor-based flow computer, a telemetry communications package, and a gas chromatograph. Live relative density (specific gravity), BTU, CO{sub 2}, and N{sub 2} are updated from the chromatograph to the flow computer every six minutes which provides accurate MMBTU computations. Because the gas contract length has changed from years to monthly and from a majority of direct sales to transports both Arkla and its customers wanted access to actual volumes on a much more timely basis than is allowed with charts. The new electronic system allows volumes and other system data to be retrieved continuously, if EFM is on Supervisory Control and Data Acquisition (SCADA) or daily if on dial up telephone. Previously because of chart integration, information was not available for four to six weeks. EFM costs much less than the combined costs of telemetry transmitters, pressure and differential pressure chart recorders, and temperature chart recorder which it replaces. APG will install this equipment on smaller volume stations at a customers expense. APG requires backup measurement on metering facilities this size. It could be another APG flow computer or chart recorder, or the other companies flow computer or chart recorder.« less

Calibration of automatic performance measures - speed and volume data: volume 2, evaluation of the accuracy of approach volume counts and speeds collected by microwave sensors.

DOT National Transportation Integrated Search

2016-05-01

This study evaluated the accuracy of approach volumes and free flow approach speeds collected by the Wavetronix : SmartSensor Advance sensor for the Signal Performance Metrics system of the Utah Department of Transportation (UDOT), : using the field ...

[Influence of transport parameters values on volume flows in the double-membrane system].

PubMed

Slezak, Andrzej; Bryll, Arkadiusz

2005-01-01

On the basis of Kedem-Katchalsky non-linear equations for the double-membrane system, research were carried out upon the influence of the transmembrane transport parameters, i.e. hydraulic permeability (Lp), reflection (sigma) and solute (omega) coefficients on the volume flows in the double-membrane system. The membrane system was composed of two membranes Ml and Mr characterized by coefficients, respectively Lpl, sigmal, omegal and Lp(r), sigmar, omegar, that separated the solutions at concentrations Cl, Cm, Cr. In order to show the influence of the membranes parameters values on the volume flow intensity, there were calculated the following dependencies: J(v sigma) = f omega(Lp)ii, Jv = f sigma(omega r)Lp,i), Jv = f sigma(sigma(omega r Lp,li), Jv = f sigma(sigma omega l Lp,ri) , (i = l, r), in conditions of set out mechanic pressure (Pl = Pr = Po = const.) and set concentrations (Cl = Cr = C = const.). The graphical pictures of the two first equations are hyperbolas and straight lines in particular cases, whereas the graphical pictures of further two dependencies are more complex.

Using a tracer technique to identify the extent of non-ideal flows in the continuous mixing of non-Newtonian fluids

NASA Astrophysics Data System (ADS)

Patel, D.; Ein-Mozaffari, F.; Mehrvar, M.

2013-05-01

The identification of non-ideal flows in a continuous-flow mixing of non-Newtonian fluids is a challenging task for various chemical industries: plastic manufacturing, water and wastewater treatment, and pulp and paper manufacturing. Non-ideal flows such as channelling, recirculation, and dead zones significantly affect the performance of continuous-flow mixing systems. Therefore, the main objective of this paper was to develop an identification protocol to measure non-ideal flows in the continuous-flow mixing system. The extent of non-ideal flows was quantified using a dynamic model that incorporated channelling, recirculation, and dead volume in the mixing vessel. To estimate the dynamic model parameters, the system was excited using a frequency-modulated random binary input by injecting the saline solution (as a tracer) into the fresh feed stream prior to being pumped into the mixing vessel. The injection of the tracer was controlled by a computer-controlled on-off solenoid valve. Using the trace technique, the extent of channelling and the effective mixed volume were successfully determined and used as mixing quality criteria. Such identification procedures can be applied at various areas of chemical engineering in order to improve the mixing quality.

Control volume based hydrocephalus research; a phantom study

NASA Astrophysics Data System (ADS)

Cohen, Benjamin; Voorhees, Abram; Madsen, Joseph; Wei, Timothy

2009-11-01

Hydrocephalus is a complex spectrum of neurophysiological disorders involving perturbation of the intracranial contents; primarily increased intraventricular cerebrospinal fluid (CSF) volume and intracranial pressure are observed. CSF dynamics are highly coupled to the cerebral blood flows and pressures as well as the mechanical properties of the brain. Hydrocephalus, as such, is a very complex biological problem. We propose integral control volume analysis as a method of tracking these important interactions using mass and momentum conservation principles. As a first step in applying this methodology in humans, an in vitro phantom is used as a simplified model of the intracranial space. The phantom's design consists of a rigid container filled with a compressible gel. Within the gel a hollow spherical cavity represents the ventricular system and a cylindrical passage represents the spinal canal. A computer controlled piston pump supplies sinusoidal volume fluctuations into and out of the flow phantom. MRI is used to measure fluid velocity and volume change as functions of time. Independent pressure measurements and momentum flow rate measurements are used to calibrate the MRI data. These data are used as a framework for future work with live patients and normal individuals. Flow and pressure measurements on the flow phantom will be presented through the control volume framework.

Sample preparation system for microfluidic applications

DOEpatents

Mosier, Bruce P [San Francisco, CA; Crocker, Robert W [Fremont, CA; Patel, Kamlesh D [Dublin, CA; Harnett, Cindy K [Livermore, CA

2007-05-08

An apparatus that couples automated injection with flow feedback to provide nanoliter accuracy in controlling microliter volumes. The apparatus comprises generally a source of hydraulic fluid pressure, a fluid isolator joined to the outlet of the hydraulic pressure source and a flow sensor to provide pressure-driven analyte metering. For operation generally and particularly in microfluidic systems the hydraulic pressure source is typically an electrokinetic (EK) pump that incorporates gasless electrodes. The apparatus is capable of metering sub-microliter volumes at flowrates of 1 100 .mu.L/min into microsystem load pressures of up to 1000 50 psi, respectively. Flowrates can be specified within 0.5 .mu.L/min and volumes as small as 80 nL can be metered.

Evaluating humidity recovery efficiency of currently available heat and moisture exchangers: a respiratory system model study.

PubMed

Lucato, Jeanette Janaina Jaber; Adams, Alexander Bernard; Souza, Rogério; Torquato, Jamili Anbar; Carvalho, Carlos Roberto Ribeiro; Marini, John J

2009-01-01

To evaluate and compare the efficiency of humidification in available heat and moisture exchanger models under conditions of varying tidal volume, respiratory rate, and flow rate. Inspired gases are routinely preconditioned by heat and moisture exchangers to provide a heat and water content similar to that provided normally by the nose and upper airways. The absolute humidity of air retrieved from and returned to the ventilated patient is an important measurable outcome of the heat and moisture exchangers' humidifying performance. Eight different heat and moisture exchangers were studied using a respiratory system analog. The system included a heated chamber (acrylic glass, maintained at 37 degrees C), a preserved swine lung, a hygrometer, circuitry and a ventilator. Humidity and temperature levels were measured using eight distinct interposed heat and moisture exchangers given different tidal volumes, respiratory frequencies and flow-rate conditions. Recovery of absolute humidity (%RAH) was calculated for each setting. Increasing tidal volumes led to a reduction in %RAH for all heat and moisture exchangers while no significant effect was demonstrated in the context of varying respiratory rate or inspiratory flow. Our data indicate that heat and moisture exchangers are more efficient when used with low tidal volume ventilation. The roles of flow and respiratory rate were of lesser importance, suggesting that their adjustment has a less significant effect on the performance of heat and moisture exchangers.

Regional blood flow volume in the eustachian tube.

PubMed

Minami, T; Kubo, N; Tomoda, K; Yamashita, T; Kumazawa, T

1993-01-01

Measurements of regional blood flow around the pharyngeal orifice of the Eustachian tube were carried out after topical administration of various inflammatory mediators in 14 mongrel dogs by the hydrogen clearance method. Histamine and platelet-activating factor (PAF) resulted in a significant alteration of blood flow volume. Histamine was found to induce a dose-response related increase, whereas blood flow volume tended to decrease in each concentration range in the series of PAF administration. There was no significant difference in blood flow between topical application of leukotriene C4 and leukotriene D4. It is likely that in upper respiratory tract inflammation, such as in otitis media and in nasal allergy, activated histamine and PAF affect the microcirculation of the tubal orifice. These results suggest that disturbance of the microcirculatory system in the Eustachian tube mucosa could be involved in the pathogenesis of chronic otitis media with effusion.

Dumbo: A pachydermal rocket motor

NASA Technical Reports Server (NTRS)

Kirk, Bill

1991-01-01

A brief historical account is given of the Dumbo nuclear reactor, a type of folded flow reactor that could be used for rocket propulsion. Much of the information is given in viewgraph form. Viewgraphs show details of the reactor system, fuel geometry, and key characteristics of the system (folded flow, use of fuel washers, large flow area, small fuel volume, hybrid modulator, and cermet fuel).

A new approach to flow-batch titration. A monosegmented flow titrator with coulometric reagent generation and potentiometric or biamperometric detection.

PubMed

de Aquino, Emerson Vidal; Rohwedder, Jarbas José Rodrigues; Pasquini, Celio

2006-11-01

Monosegmented flow analysis (MSFA) has been used as a flow-batch system to produce a simple, robust, and mechanized titrator that enables true titrations to be performed without the use of standards. This paper also introduces the use of coulometry with monosegmented titration by proposing a versatile flow cell. Coulometric generation of the titrand is attractive for titrations performed in monosegmented systems, because the reagent can be added without increasing the volume of sample injected. Also, biamperomeric and potentiometric detection of titration end-points can increase the versatility of the monosegmented titrator. The cell integrates coulometric generation of the titrand with detection of end-point by potentiometry or biamperometry. The resulting titrator is a flow-batch system in which the liquid monosegment, constrained by the interfaces of the gaseous carrier stream, plays the role of a sample of known volume to be titrated. The system has been used for determination of ascorbic acid, by coulometric generation of I2 with biamperometric detection, and for determination of Fe(II), by coulometric generation of Ce(IV) with potentiometric detection of the end-point, both in feed supplements.

Morphologic and Morphometric Studies of Integrated Gully Systems on Mars

NASA Astrophysics Data System (ADS)

Gulick, V. C.; Glines, N. H.; Freeman, P. M.; Morkner, P.; Narlesky, C.

2016-12-01

We have been conducting detailed morphologic and morphometric studies of gullies formed in various environmental settings on Mars using HiRISE images and DTMs. Several highly integrated gully systems have concave longitudinal profiles similar to those of terrestrial fluvial systems. Importantly, we do not see significant evidence for debris flow lobes or deposits on the floors of the gullies, either in their profiles or in the HiRISE stereo images, as would be expected for debris flows or other dry processes. Instead, deviations in the profile concavity generally correlate with gullies incising through stratigraphic layers. We also note several interesting correlations/associations in our study locations. 1) RSL are often found either in the tributaries of these integrated systems or in adjacent regions. Therefore, this implies that RSL may play a role in initiating gully formation and/or mark the last vestiges of water activity in these locations. 2) The more highly integrated gullies have eroded volumes significantly larger than their deposited apron volumes, suggesting that the missing volumes may reflect the volatile volumes involved in gully formation. In contrast, the Matara dune gully, which is less integrated, has minimal volume discrepancy. 3) THEMIS and TES surface temperatures of these gully sites, many of which contain RSL, approach or exceed 273K seasonally, suggesting that the volatile component is consistent with H2O, although CO2 may also play a role particularly during other seasons. 4) Apron volumes that equal or exceed their gully volumes suggest that dry flows, avalanching, gully infill, or other dry processes may have been more important in these less integrated systems. These associations suggest that although there are various gully morphologies on Mars that reflect the involvement of multiple processes, we find gully systems in Moni, Corozal, Palikir, and Lyot craters to be consistent with a primary formation by fluvial processes.

A microfabricated bio-sensor for erythrocytes deformability and volume distributions analysis

NASA Astrophysics Data System (ADS)

Bransky, Avishay; Korin, Natanel; Nemirovski, Yael; Dinnar, Uri

2007-12-01

The deformability of erythrocytes is of great importance for oxygen delivery in the microcirculation. Reduced RBC deformability is associated with several types of hemolytic anaemias, malaria, sepsis and diabetes. Aging of erythrocytes is also associated with loss of deformability as well as reduction in cell volume. An automated rheoscope has been developed, utilizing a microfabricated glass flow cell, high speed camera and advanced image-processing software. RBCs suspended in a high viscosity medium were filmed flowing through a microchannel. The system produces valuable data such as velocity profiles of RBCs, spatial distribution within the microchannel, cell volume and deformation index (DI) curves. The variation of DI across the channel height, due to change in shear stress, was measured for the first time. Such DI curves were obtained for normal and Thalassemia RBCs and their diagnostic potential was demonstrated. The spatial distribution and velocity of RBCs and rigid microspheres were measured. Both RBC and rigid spheres showed enhanced inward lateral migration, however the RBCs form a depletion region at the center of flow. The volume and surface area of the flowing cells have been estimated based on a fluid mechanics model and experimental results and fell within the normal range. Hence, the system developed, provides means for examining the behavior of individual RBCs in microchannels, and may serve as a microfabricated diagnostic device for deformability and volume measurements.

Monitoring and analysis of combined sewer overflows, Riverside and Evanston, Illinois, 1997-99

USGS Publications Warehouse

Waite, Andrew M.; Hornewer, Nancy J.; Johnson, Gary P.

2002-01-01

The U.S. Geological Survey, in cooperation with the U.S. Army Corps of Engineers, collected and analyzed flow data in combined sewer systems in Riverside and Evanston, northeastern Illinois, from March 1997 to December 1999. Continuous 2- and 5-minute stage and velocity data were collected during surcharged and nonsurcharged conditions at 12 locations. Mass balances were calculated to determine the volume of water flowing through the tide-gate openings to the Des Plaines River and the North Shore Channel and to determine the volume of water flowing past the sluice gate to the deep tunnel. The sewer systems consist of circular pipes ranging in diameter from 0.83 feet to 10.0 feet, elliptical siphon pipes, ledges, and tide and sluice gates. Pipes were constructed of either brick and mortar or concrete, and ranged from having smooth surfaces to rough, pitted and crumbling surfaces. One pipe was noticeably affected by water infiltration from saturated ground. During data analysis, many assumptions were necessary because of the complexity of the flow data and sewer-system configurations. These assumptions included estimating the volume of water entering an interceptor sewer at the ''Gage Street pipe'' at Riverside, the effect of infiltration on the ''brick pipe'' at Riverside, and the minimum velocity required for the meter to make an accurate velocity determination. Other factors affecting the analysis of flow data included possible non-instrumented sources of inflow, and backwater conditions in some pipes, which could have caused error in the data analysis. Variations of these assumptions potentially could cause appreciable changes to the final massbalance calculations. Mass-balance analysis at Riverside indicated a total inflow volume into chamber 3 of approximately 721,000 cubic feet (ft3) during April 22-26, 1999. Outflow volume to the Des Plaines River at Riverside through the tide gate was approximately 132,000 ft3; outflow volume to the deep tunnel through the sluice gate was approximately 267,000 ft3. The mass-balance analysis at Evanston indicated a total inflow volume into chamber 3 of approximately 5,970,000 ft3 during April 21-26, 1999. The outflow volume to the North Shore Channel through the tide gates at Evanston was approximately 2,920,000 ft3; outflow volume to the deep tunnel through the sluice gates was approximately 3,050,000 ft3.

Freight Transportation : A Digest of Technical Papers. Volume 1.

DOT National Transportation Integrated Search

1976-10-28

This volume contains a number of technical papers dealing with intercity freight transportation. Collectively, these systems-oriented papers consider a wide range of subject matter including transportation facilitation, commodity flow, regulation, au...

Development and Application of a Low-Volume Flow System for Solution-State in Vivo NMR.

PubMed

Tabatabaei Anaraki, Maryam; Dutta Majumdar, Rudraksha; Wagner, Nicole; Soong, Ronald; Kovacevic, Vera; Reiner, Eric J; Bhavsar, Satyendra P; Ortiz Almirall, Xavier; Lane, Daniel; Simpson, Myrna J; Heumann, Hermann; Schmidt, Sebastian; Simpson, André J

2018-06-18

In vivo nuclear magnetic resonance (NMR) spectroscopy is a particularly powerful technique, since it allows samples to be analyzed in their natural, unaltered state, criteria paramount for living organisms. In this study, a novel continuous low-volume flow system, suitable for in vivo NMR metabolomics studies, is demonstrated. The system allows improved locking, shimming, and water suppression, as well as allowing the use of trace amounts of expensive toxic contaminants or low volumes of precious natural environmental samples as stressors. The use of a double pump design with a sump slurry pump return allows algal food suspensions to be continually supplied without the need for filters, eliminating the possibility of clogging and leaks. Using the flow system, the living organism can be kept alive without stress indefinitely. To evaluate the feasibility and applicability of the flow system, changes in the metabolite profile of 13 C enriched Daphnia magna over a 24-h period are compared when feeding laboratory food vs exposing them to a natural algal bloom sample. Clear metabolic changes are observed over a range of metabolites including carbohydrates, lipids, amino acids, and a nucleotide demonstrating in vivo NMR as a powerful tool to monitor environmental stress. The particular bloom used here was low in microcystins, and the metabolic stress impacts are consistent with the bloom being a poor food source forcing the Daphnia to utilize their own energy reserves.

Influence of Gravity on Blood Volume and Flow Distribution

NASA Technical Reports Server (NTRS)

Pendergast, D.; Olszowka, A.; Bednarczyk, E.; Shykoff, B.; Farhi, L.

1999-01-01

In our previous experiments during NASA Shuttle flights SLS 1 and 2 (9-15 days) and EUROMIR flights (30-90 days) we observed that pulmonary blood flow (cardiac output) was elevated initially, and surprisingly remained elevated for the duration of the flights. Stroke volume increased initially and then decreased, but was still above 1 Gz values. As venous return was constant, the changes in SV were secondary to modulation of heart rate. Mean blood pressure was at or slightly below 1 Gz levels in space, indicating a decrease in total peripheral resistance. It has been suggested that plasma volume is reduced in space, however cardiac output/venous return do not return to 1 Gz levels over the duration of flight. In spite of the increased cardiac output, central venous pressure was not elevated in space. These data suggest that there is a change in the basic relationship between cardiac output and central venous pressure, a persistent "hyperperfusion" and a re-distribution of blood flow and volume during space flight. Increased pulmonary blood flow has been reported to increase diffusing capacity in space, presumably due to the improved homogeneity of ventilation and perfusion. Other studies have suggested that ventilation may be independent of gravity, and perfusion may not be gravity- dependent. No data for the distribution of pulmonary blood volume were available for flight or simulated microgravity. Recent studies have suggested that the pulmonary vascular tree is influenced by sympathetic tone in a manner similar to that of the systemic system. This implies that the pulmonary circulation is dilated during microgravity and that the distribution of blood flow and volume may be influenced more by vascular control than by gravity. The cerebral circulation is influenced by sympathetic tone similarly to that of the systemic and pulmonary circulations; however its effects are modulated by cerebral autoregulation. Thus it is difficult to predict if cerebral perfusion is increased and if there is edema in space. Anecdotal evidence suggests there may be cerebral edema early in flight. Cerebral artery velocity has been shown to be elevated in simulated microgravity. The elevated cerebral artery velocity during simulated microgravity may reflect vasoconstriction of the arteries and not increased cerebral blood flow. The purpose of our investigations was to evaluate the effects of alterations in simulated gravity (+/-), resulting in changes in cardiac output (+/-), and on the blood flow and volume distribution in the lung and brain of human subjects. The first hypothesis of these studies was that blood flow and volume would be affected by gravity, but their distribution in the lung would be independent of gravity and due to vasoactivity changing vascular resistance in lung vessels. The vasodilitation of the lung vasculature (lower resistance) along with increased "compliance" of the heart could account for the absence of increased central venous pressure in microgravity. Secondly, we postulate that cerebral blood velocity is increased in microgravity due to large artery vasoconstriction, but that cerebral blood flow would be reduced due to autoregulation.

Numerical Cerebrospinal System Modeling in Fluid-Structure Interaction.

PubMed

Garnotel, Simon; Salmon, Stéphanie; Balédent, Olivier

2018-01-01

Cerebrospinal fluid (CSF) stroke volume in the aqueduct is widely used to evaluate CSF dynamics disorders. In a healthy population, aqueduct stroke volume represents around 10% of the spinal stroke volume while intracranial subarachnoid space stroke volume represents 90%. The amplitude of the CSF oscillations through the different compartments of the cerebrospinal system is a function of the geometry and the compliances of each compartment, but we suspect that it could also be impacted be the cardiac cycle frequency. To study this CSF distribution, we have developed a numerical model of the cerebrospinal system taking into account cerebral ventricles, intracranial subarachnoid spaces, spinal canal and brain tissue in fluid-structure interactions. A numerical fluid-structure interaction model is implemented using a finite-element method library to model the cerebrospinal system and its interaction with the brain based on fluid mechanics equations and linear elasticity equations coupled in a monolithic formulation. The model geometry, simplified in a first approach, is designed in accordance with realistic volume ratios of the different compartments: a thin tube is used to mimic the high flow resistance of the aqueduct. CSF velocity and pressure and brain displacements are obtained as simulation results, and CSF flow and stroke volume are calculated from these results. Simulation results show a significant variability of aqueduct stroke volume and intracranial subarachnoid space stroke volume in the physiological range of cardiac frequencies. Fluid-structure interactions are numerous in the cerebrospinal system and difficult to understand in the rigid skull. The presented model highlights significant variations of stroke volumes under cardiac frequency variations only.

System Design Verification for Closed Loop Control of Oxygenation With Concentrator Integration.

PubMed

Gangidine, Matthew M; Blakeman, Thomas C; Branson, Richard D; Johannigman, Jay A

2016-05-01

Addition of an oxygen concentrator into a control loop furthers previous work in autonomous control of oxygenation. Software integrates concentrator and ventilator function from a single control point, ensuring maximum efficiency by placing a pulse of oxygen at the beginning of the breath. We sought to verify this system. In a test lung, fraction of inspired oxygen (FIO2) levels and additional data were monitored. Tests were run across a range of clinically relevant ventilator settings in volume control mode, for both continuous flow and pulse dose flow oxygenation. Results showed the oxygen concentrator could maintain maximum pulse output (192 mL) up to 16 breaths per minute. Functionality was verified across ranges of tidal volumes and respiratory rates, with and without positive end-expiratory pressure, in continuous flow and pulse dose modes. For a representative test at respiratory rate 16 breaths per minute, tidal volume 550 mL, without positive end-expiratory pressure, pulse dose oxygenation delivered peak FIO2 of 76.83 ± 1.41%, and continuous flow 47.81 ± 0.08%; pulse dose flow provided a higher FIO2 at all tested setting combinations compared to continuous flow (p < 0.001). These tests verify a system that provides closed loop control of oxygenation while integrating time-coordinated pulse-doses from an oxygen concentrator. This allows the most efficient use of resources in austere environments. Reprint & Copyright © 2016 Association of Military Surgeons of the U.S.

Experimental investigation of the mass flow gain factor in a draft tube with cavitation vortex rope

NASA Astrophysics Data System (ADS)

Landry, C.; Favrel, A.; Müller, A.; Yamamoto, K.; Alligné, S.; Avellan, F.

2017-04-01

At off-design operating operations, cavitating flow is often observed in hydraulic machines. The presence of a cavitation vortex rope may induce draft tube surge and electrical power swings at part load and full load operations. The stability analysis of these operating conditions requires a numerical pipe model taking into account the complexity of the two-phase flow. Among the hydroacoustic parameters describing the cavitating draft tube flow in the numerical model, the mass flow gain factor, representing the mass excitation source expressed as the rate of change of the cavitation volume as a function of the discharge, remains difficult to model. This paper presents a quasi-static method to estimate the mass flow gain factor in the draft tube for a given cavitation vortex rope volume in the case of a reduced scale physical model of a ν = 0.27 Francis turbine. The methodology is based on an experimental identification of the natural frequency of the test rig hydraulic system for different Thoma numbers. With the identification of the natural frequency, it is possible to model the wave speed, the cavitation compliance and the volume of the cavitation vortex rope. By applying this new methodology for different discharge values, it becomes possible to identify the mass flow gain factor and improve the accuracy of the system stability analysis.

Use of a novel drainage flow servo-controlled CPB for mitral valve replacement in a Jehovah's Witness.

PubMed

Niimi, Yoshinari; Murata, Seiichiro; Mitou, Yumi; Ohno, Yusuke

2018-03-01

We developed a novel open cardiopulmonary bypass (CPB) system, a drainage flow servo-controlled CPB system (DS-CPB), in which rotational speed of the main roller pump is servo-controlled to generate the same amount of flow as the systemic venous drainage. It was designed to safely decrease the priming volume while maintaining a constant reservoir level, even during fluctuations of the drainage flow. We report a successful use of a novel DS-CPB system in an elderly Jehovah's Witness patient with dehydration who underwent mitral valve replacement.

A solution algorithm for fluid–particle flows across all flow regimes

DOE PAGES

Kong, Bo; Fox, Rodney O.

2017-05-12

Many fluid–particle flows occurring in nature and in technological applications exhibit large variations in the local particle volume fraction. For example, in circulating fluidized beds there are regions where the particles are closepacked as well as very dilute regions where particle–particle collisions are rare. Thus, in order to simulate such fluid–particle systems, it is necessary to design a flow solver that can accurately treat all flow regimes occurring simultaneously in the same flow domain. In this work, a solution algorithm is proposed for this purpose. The algorithm is based on splitting the free-transport flux solver dynamically and locally in themore » flow. In close-packed to moderately dense regions, a hydrodynamic solver is employed, while in dilute to very dilute regions a kinetic-based finite-volume solver is used in conjunction with quadrature-based moment methods. To illustrate the accuracy and robustness of the proposed solution algorithm, it is implemented in OpenFOAM for particle velocity moments up to second order, and applied to simulate gravity-driven, gas–particle flows exhibiting cluster-induced turbulence. By varying the average particle volume fraction in the flow domain, it is demonstrated that the flow solver can handle seamlessly all flow regimes present in fluid–particle flows.« less

A solution algorithm for fluid-particle flows across all flow regimes

NASA Astrophysics Data System (ADS)

Kong, Bo; Fox, Rodney O.

2017-09-01

Many fluid-particle flows occurring in nature and in technological applications exhibit large variations in the local particle volume fraction. For example, in circulating fluidized beds there are regions where the particles are close-packed as well as very dilute regions where particle-particle collisions are rare. Thus, in order to simulate such fluid-particle systems, it is necessary to design a flow solver that can accurately treat all flow regimes occurring simultaneously in the same flow domain. In this work, a solution algorithm is proposed for this purpose. The algorithm is based on splitting the free-transport flux solver dynamically and locally in the flow. In close-packed to moderately dense regions, a hydrodynamic solver is employed, while in dilute to very dilute regions a kinetic-based finite-volume solver is used in conjunction with quadrature-based moment methods. To illustrate the accuracy and robustness of the proposed solution algorithm, it is implemented in OpenFOAM for particle velocity moments up to second order, and applied to simulate gravity-driven, gas-particle flows exhibiting cluster-induced turbulence. By varying the average particle volume fraction in the flow domain, it is demonstrated that the flow solver can handle seamlessly all flow regimes present in fluid-particle flows.

A solution algorithm for fluid–particle flows across all flow regimes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kong, Bo; Fox, Rodney O.

Many fluid–particle flows occurring in nature and in technological applications exhibit large variations in the local particle volume fraction. For example, in circulating fluidized beds there are regions where the particles are closepacked as well as very dilute regions where particle–particle collisions are rare. Thus, in order to simulate such fluid–particle systems, it is necessary to design a flow solver that can accurately treat all flow regimes occurring simultaneously in the same flow domain. In this work, a solution algorithm is proposed for this purpose. The algorithm is based on splitting the free-transport flux solver dynamically and locally in themore » flow. In close-packed to moderately dense regions, a hydrodynamic solver is employed, while in dilute to very dilute regions a kinetic-based finite-volume solver is used in conjunction with quadrature-based moment methods. To illustrate the accuracy and robustness of the proposed solution algorithm, it is implemented in OpenFOAM for particle velocity moments up to second order, and applied to simulate gravity-driven, gas–particle flows exhibiting cluster-induced turbulence. By varying the average particle volume fraction in the flow domain, it is demonstrated that the flow solver can handle seamlessly all flow regimes present in fluid–particle flows.« less

Houston-Galveston Navigation Channels, Texas Project. Navigation Channel Sedimentation Study, Phase 2

DTIC Science & Technology

2008-07-01

volume of the system is 64 L. The propeller pump is 2.6 m upstream from the bed sediment sample tray . Flows in the VOST are up to 1.54 m/s, generating...159 High Flow Water Year...160 Low Flow Water Year

The RAAF Logistics Study. Volume 3,

DTIC Science & Technology

human activity system which has been analysed by the Central Studies Establishment on behalf of the Defence Logistics Organisation. This work, now reported on, stems from a conviction that improved decision making can flow from an enhanced and integrated understanding of the activities necessary to fulfil the objectives of the system, by those involved in it or affected by it. This particular Volume deals with the description, using the Soft Systems Methodology described in Volume 1, of the RAAF Technical System which constitutes a major component of the overall RAAF

Evaluating Humidity Recovery Efficiency of Currently Available Heat and Moisture Exchangers: A Respiratory System Model Study

PubMed Central

Lucato, Jeanette Janaina Jaber; Adams, Alexander Bernard; Souza, Rogério; Torquato, Jamili Anbar; Carvalho, Carlos Roberto Ribeiro; Marini, John J

2009-01-01

OBJECTIVES: To evaluate and compare the efficiency of humidification in available heat and moisture exchanger models under conditions of varying tidal volume, respiratory rate, and flow rate. INTRODUCTION: Inspired gases are routinely preconditioned by heat and moisture exchangers to provide a heat and water content similar to that provided normally by the nose and upper airways. The absolute humidity of air retrieved from and returned to the ventilated patient is an important measurable outcome of the heat and moisture exchangers’ humidifying performance. METHODS: Eight different heat and moisture exchangers were studied using a respiratory system analog. The system included a heated chamber (acrylic glass, maintained at 37°C), a preserved swine lung, a hygrometer, circuitry and a ventilator. Humidity and temperature levels were measured using eight distinct interposed heat and moisture exchangers given different tidal volumes, respiratory frequencies and flow-rate conditions. Recovery of absolute humidity (%RAH) was calculated for each setting. RESULTS: Increasing tidal volumes led to a reduction in %RAH for all heat and moisture exchangers while no significant effect was demonstrated in the context of varying respiratory rate or inspiratory flow. CONCLUSIONS: Our data indicate that heat and moisture exchangers are more efficient when used with low tidal volume ventilation. The roles of flow and respiratory rate were of lesser importance, suggesting that their adjustment has a less significant effect on the performance of heat and moisture exchangers. PMID:19578664

Development of limb volume measuring system

NASA Technical Reports Server (NTRS)

Bhagat, P. K.; Kadaba, P. K.

1983-01-01

The mechanisms underlying the reductions in orthostatic tolerance associated with weightlessness are not well established. Contradictory results from measurements of leg volume changes suggest that altered venomotor tone and reduced blood flow may not be the only contributors to orthostatic intolerance. It is felt that a more accurate limb volume system which is insensitive to environmental factors will aid in better quantification of the hemodynamics of the leg. Of the varous limb volume techniques presently available, the ultrasonic limb volume system has proven to be the best choice. The system as described herein is free from environmental effects, safe, simple to operate and causes negligible radio frequency interference problems. The segmental ultrasonic ultrasonic plethysmograph is expected to provide a better measurement of limb volume change since it is based on cross-sectional area measurements.

Developing Expert Systems

DOT National Transportation Integrated Search

1974-10-01

The basic manual, published as the first volume of this report, is intended for use as a tool in predicting noise levels which will be generated by freely-flowing vehicle traffic along a highway of known characteristics. The first volume explains the...

Nonlinear Conservation Laws and Finite Volume Methods

NASA Astrophysics Data System (ADS)

Leveque, Randall J.

Introduction Software Notation Classification of Differential Equations Derivation of Conservation Laws The Euler Equations of Gas Dynamics Dissipative Fluxes Source Terms Radiative Transfer and Isothermal Equations Multi-dimensional Conservation Laws The Shock Tube Problem Mathematical Theory of Hyperbolic Systems Scalar Equations Linear Hyperbolic Systems Nonlinear Systems The Riemann Problem for the Euler Equations Numerical Methods in One Dimension Finite Difference Theory Finite Volume Methods Importance of Conservation Form - Incorrect Shock Speeds Numerical Flux Functions Godunov's Method Approximate Riemann Solvers High-Resolution Methods Other Approaches Boundary Conditions Source Terms and Fractional Steps Unsplit Methods Fractional Step Methods General Formulation of Fractional Step Methods Stiff Source Terms Quasi-stationary Flow and Gravity Multi-dimensional Problems Dimensional Splitting Multi-dimensional Finite Volume Methods Grids and Adaptive Refinement Computational Difficulties Low-Density Flows Discrete Shocks and Viscous Profiles Start-Up Errors Wall Heating Slow-Moving Shocks Grid Orientation Effects Grid-Aligned Shocks Magnetohydrodynamics The MHD Equations One-Dimensional MHD Solving the Riemann Problem Nonstrict Hyperbolicity Stiffness The Divergence of B Riemann Problems in Multi-dimensional MHD Staggered Grids The 8-Wave Riemann Solver Relativistic Hydrodynamics Conservation Laws in Spacetime The Continuity Equation The 4-Momentum of a Particle The Stress-Energy Tensor Finite Volume Methods Multi-dimensional Relativistic Flow Gravitation and General Relativity References

Site characterization methodology for aquifers in support of bioreclamation activities. Volume 2: Borehole flowmeter technique, tracer tests, geostatistics and geology. Final report, August 1987-September 1989

DOE Office of Scientific and Technical Information (OSTI.GOV)

Young, S.C.

1993-08-01

This report discusses a field demonstration of a methodology for characterizing an aquifer's geohydrology in the detail required to design an optimum network of wells and/or infiltration galleries for bioreclamation systems. The project work was conducted on a 1-hectare test site at Columbus AFB, Mississippi. The technical report is divided into two volumes. Volume I describes the test site and the well network, the assumptions, and the application of equations that define groundwater flow to a well, the results of three large-scale aquifer tests, and the results of 160 single-pump tests. Volume II describes the bore hole flowmeter tests, themore » tracer tests, the geological investigations, the geostatistical analysis and the guidelines for using groundwater models to design bioreclamation systems. Site characterization, Hydraulic conductivity, Groundwater flow, Geostatistics, Geohydrology, Monitoring wells.« less

Optimization of radioactive sources to achieve the highest precision in three-phase flow meters using Jaya algorithm.

PubMed

Roshani, G H; Karami, A; Khazaei, A; Olfateh, A; Nazemi, E; Omidi, M

2018-05-17

Gamma ray source has very important role in precision of multi-phase flow metering. In this study, different combination of gamma ray sources (( 133 Ba- 137 Cs), ( 133 Ba- 60 Co), ( 241 Am- 137 Cs), ( 241 Am- 60 Co), ( 133 Ba- 241 Am) and ( 60 Co- 137 Cs)) were investigated in order to optimize the three-phase flow meter. Three phases were water, oil and gas and the regime was considered annular. The required data was numerically generated using MCNP-X code which is a Monte-Carlo code. Indeed, the present study devotes to forecast the volume fractions in the annular three-phase flow, based on a multi energy metering system including various radiation sources and also one NaI detector, using a hybrid model of artificial neural network and Jaya Optimization algorithm. Since the summation of volume fractions is constant, a constraint modeling problem exists, meaning that the hybrid model must forecast only two volume fractions. Six hybrid models associated with the number of used radiation sources are designed. The models are employed to forecast the gas and water volume fractions. The next step is to train the hybrid models based on numerically obtained data. The results show that, the best forecast results are obtained for the gas and water volume fractions of the system including the ( 241 Am- 137 Cs) as the radiation source. Copyright © 2018 Elsevier Ltd. All rights reserved.

Stage-by-Stage and Parallel Flow Path Compressor Modeling for a Variable Cycle Engine

NASA Technical Reports Server (NTRS)

Kopasakis, George; Connolly, Joseph W.; Cheng, Larry

2015-01-01

This paper covers the development of stage-by-stage and parallel flow path compressor modeling approaches for a Variable Cycle Engine. The stage-by-stage compressor modeling approach is an extension of a technique for lumped volume dynamics and performance characteristic modeling. It was developed to improve the accuracy of axial compressor dynamics over lumped volume dynamics modeling. The stage-by-stage compressor model presented here is formulated into a parallel flow path model that includes both axial and rotational dynamics. This is done to enable the study of compressor and propulsion system dynamic performance under flow distortion conditions. The approaches utilized here are generic and should be applicable for the modeling of any axial flow compressor design.

[THE STATE OF HEPATIC AND SPLANCHNIC BLOOD FLOW IN VARIOUS TYPES OF COMPLICATED PANCREATIC PSEUDOCYSTS].

PubMed

Kryvoruchko, I A; Goncharova, N M; Andreyeshchev, S A; Yavorska, T P

2015-05-01

Investigations were conducted in 37 patients, suffering complicated pancreatic pseudocysts. In accordance to data of ultrasound Doppler flowmetry for the blood flow along portal vein, a. hepatis communis, a. mesenterica superior in complicated pancreatic pseudocysts compensatory--adaptive reactions on level of hepatic--spanchnic blood flow are directed towards restriction of the blood inflow through the portal vein system. This is accompanied by the common peripheral vascular resistence raising in basin of a. mesenterica superior, which have depended upon the patients' state severity, caused by reduction of the volume blood flow in a certan vascular collector. The oxygen debt of the liver in these patients is compensated by the volume blood flow enhancement along a. hepatis communis.

A Feasibility Study of Pressure Retarded Osmosis Power Generation System based on Measuring Permeation Volume using Reverse Osmosis Membrane

NASA Astrophysics Data System (ADS)

Enomoto, Hiroshi; Fujitsuka, Masashi; Hasegawa, Tomoyasu; Kuwada, Masatoshi; Tanioka, Akihiko; Minagawa, Mie

Pressure Retarded Osmosis (PRO) power generation system is a hydroelectric power system which utilize permeation flow through a semi-permeable membrane. Permeation flow is generated by potential energy of salinity difference between sea water and fresh water. As membrane cost is expensive, permeation performance of membrane must be higher to realize PRO system. We have investigated Reverse Osmosis (RO) membrane products as semi-permeable membrane and measured permeation volume of a few products. Generation power by membrane area calculated from permeation volume is about 0.62W/m2. But by our improvements (more salt water volume, spacer of fresh water channel with a function of discharging concentrated salinity, extra low pressure type of membrane, washing support layer of membrane when generation power reduces to half), generation power may be 2.43W/m2. Then power system cost is about 4.1 million yen/kW. In addition, if support layer of membrane makes thinner and PRO system is applied to the equipment that pumping power on another purpose is avairable (wastewater treatment plant located at the seaside, thermal and nuclear power plant or sea water desalination plant), generation power may be more. By these improvements PRO system may be able to realize at the cost close to photovoltaic power system.

One-Dimensional Ablation with Pyrolysis Gas Flow Using a Full Newton's Method and Finite Control Volume Procedure

NASA Technical Reports Server (NTRS)

Amar, Adam J.; Blackwell, Ben F.; Edwards, Jack R.

2007-01-01

The development and verification of a one-dimensional material thermal response code with ablation is presented. The implicit time integrator, control volume finite element spatial discretization, and Newton's method for nonlinear iteration on the entire system of residual equations have been implemented and verified for the thermochemical ablation of internally decomposing materials. This study is a continuation of the work presented in "One-Dimensional Ablation with Pyrolysis Gas Flow Using a Full Newton's Method and Finite Control Volume Procedure" (AIAA-2006-2910), which described the derivation, implementation, and verification of the constant density solid energy equation terms and boundary conditions. The present study extends the model to decomposing materials including decomposition kinetics, pyrolysis gas flow through the porous char layer, and a mixture (solid and gas) energy equation. Verification results are presented for the thermochemical ablation of a carbon-phenolic ablator which involves the solution of the entire system of governing equations.

Slug sizing/slug volume prediction, state of the art review and simulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burke, N.E.; Kashou, S.F.

1995-12-01

Slug flow is a flow pattern commonly encountered in offshore multiphase flowlines. It is characterized by an alternate flow of liquid slugs and gas pockets, resulting in an unsteady hydrodynamic behavior. All important design variables, such as slug length and slug frequency, liquid holdup, and pressure drop, vary with time and this makes the prediction of slug flow characteristics both difficult and challenging. This paper reviews the state of the art methods in slug catcher sizing and slug volume predictions. In addition, history matching of measured slug flow data is performed using the OLGA transient simulator. This paper reviews themore » design factors that impact slug catcher sizing during steady state, during transient, during pigging, and during operations under a process control system. The slug tracking option of the OLGA simulator is applied to predict the slug length and the slug volume during a field operation. This paper will also comment on the performance of common empirical slug prediction correlations.« less

Slug-sizing/slug-volume prediction: State of the art review and simulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burke, N.E.; Kashou, S.F.

1996-08-01

Slug flow is a flow pattern commonly encountered in offshore multiphase flowlines. It is characterized by an alternate flow of liquid slugs and gas pockets, resulting in an unsteady hydrodynamic behavior. All important design variables, such as slug length and slug frequency, liquid holdup, and pressure drop, vary with time and this makes the prediction of slug flow characteristics both difficult and challenging. This paper reviews the state of the art methods in slug-catcher sizing and slug-volume predictions. In addition, history matching of measured slug flow data is performed using the OLGA transient simulator. This paper reviews the design factorsmore » that impact slug-catcher sizing during steady state, during transient, during pigging, and during operations under a process-control system. The slug-tracking option of the simulator is applied to predict the slug length and the slug volume during a field operation. This paper will also comment on the performance of common empirical slug-prediction correlations.« less

[Development of automatic urine monitoring system].

PubMed

Wei, Liang; Li, Yongqin; Chen, Bihua

2014-03-01

An automatic urine monitoring system is presented to replace manual operation. The system is composed of the flow sensor, MSP430f149 single chip microcomputer, human-computer interaction module, LCD module, clock module and memory module. The signal of urine volume is captured when the urine flows through the flow sensor and then displayed on the LCD after data processing. The experiment results suggest that the design of the monitor provides a high stability, accurate measurement and good real-time, and meets the demand of the clinical application.

Forced underwater laminar flows with active magnetohydrodynamic metamaterials

NASA Astrophysics Data System (ADS)

Culver, Dean; Urzhumov, Yaroslav

2017-12-01

Theory and practical implementations for wake-free propulsion systems are proposed and proven with computational fluid dynamic modeling. Introduced earlier, the concept of active hydrodynamic metamaterials is advanced by introducing magnetohydrodynamic metamaterials, structures with custom-designed volumetric distribution of Lorentz forces acting on a conducting fluid. Distributions of volume forces leading to wake-free, laminar flows are designed using multivariate optimization. Theoretical indications are presented that such flows can be sustained at arbitrarily high Reynolds numbers. Moreover, it is shown that in the limit Re ≫102 , a fixed volume force distribution may lead to a forced laminar flow across a wide range of Re numbers, without the need to reconfigure the force-generating metamaterial. Power requirements for such a device are studied as a function of the fluid conductivity. Implications to the design of distributed propulsion systems underwater and in space are discussed.

Effects of hypoxia on cochlear blood flow in mice evaluated using Doppler optical microangiography.

PubMed

Dziennis, Suzan; Reif, Roberto; Zhi, Zhongwei; Nuttall, Alfred L; Wang, Ruikang K

2012-10-01

Reduced cochlear blood flow (CoBF) is a main contributor to hearing loss. Studying CoBF has remained a challenge due to the lack of available tools. Doppler optical microangiography (DOMAG), a method to quantify single-vessel absolute blood flow, and laser Doppler flowmetry (LDF), a method for measuring the relative blood flow within a large volume of tissue, were used for determining the changes in CoBF due to systemic hypoxia in mice. DOMAG determined the change in blood flow in the apical turn (AT) with single-vessel resolution, while LDF averaged the change in the blood flow within a large volume of the cochlea (hemisphere with ∼1 to 1.5 mm radius). Hypoxia was induced by decreasing the concentration of oxygen-inspired gas, so that the oxygen saturation was reduced from >95% to ∼80%. DOMAG determined that during hypoxia the blood flow in two areas of the AT near and far from the helicotrema were increased and decreased, respectively. The LDF detected a decrease in blood flow within a larger volume of the cochlea (several turns averaged together). Therefore, the use of DOMAG as a tool for studying cochlear blood flow due to its ability to determine absolute flow values with single-vessel resolution was proposed.

Effects of hypoxia on cochlear blood flow in mice evaluated using Doppler optical microangiography

NASA Astrophysics Data System (ADS)

Dziennis, Suzan; Reif, Roberto; Zhi, Zhongwei; Nuttall, Alfred L.; Wang, Ruikang K.

2012-10-01

Reduced cochlear blood flow (CoBF) is a main contributor to hearing loss. Studying CoBF has remained a challenge due to the lack of available tools. Doppler optical microangiography (DOMAG), a method to quantify single-vessel absolute blood flow, and laser Doppler flowmetry (LDF), a method for measuring the relative blood flow within a large volume of tissue, were used for determining the changes in CoBF due to systemic hypoxia in mice. DOMAG determined the change in blood flow in the apical turn (AT) with single-vessel resolution, while LDF averaged the change in the blood flow within a large volume of the cochlea (hemisphere with ˜1 to 1.5 mm radius). Hypoxia was induced by decreasing the concentration of oxygen-inspired gas, so that the oxygen saturation was reduced from >95% to ˜80%. DOMAG determined that during hypoxia the blood flow in two areas of the AT near and far from the helicotrema were increased and decreased, respectively. The LDF detected a decrease in blood flow within a larger volume of the cochlea (several turns averaged together). Therefore, the use of DOMAG as a tool for studying cochlear blood flow due to its ability to determine absolute flow values with single-vessel resolution was proposed.

An experimental evaluation of the effect of homogenization quality as a preconditioning on oil-water two-phase volume fraction measurement accuracy using gamma-ray attenuation technique

NASA Astrophysics Data System (ADS)

Sharifzadeh, M.; Hashemabadi, S. H.; Afarideh, H.; Khalafi, H.

2018-02-01

The problem of how to accurately measure multiphase flow in the oil/gas industry remains as an important issue since the early 80 s. Meanwhile, oil-water two-phase flow rate measurement has been regarded as an important issue. Gamma-ray attenuation is one of the most commonly used methods for phase fraction measurement which is entirely dependent on the flow regime variations. The peripheral strategy applied for removing the regime dependency problem, is using a homogenization system as a preconditioning tool, as this research work demonstrates. Here, at first, TPFHL as a two-phase flow homogenizer loop has been introduced and verified by a quantitative assessment. In the wake of this procedure, SEMPF as a static-equivalent multiphase flow with an additional capability for preparing a uniform mixture has been explained. The proposed idea in this system was verified by Monte Carlo simulations. Finally, the different water-gas oil two-phase volume fractions fed to the homogenizer loop and injected into the static-equivalent system. A comparison between performance of these two systems by using gamma-ray attenuation technique, showed not only an extra ability to prepare a homogenized mixture but a remarkably increased measurement accuracy for the static-equivalent system.

Internal jugular and vertebral vein volume flow in patients with clinically isolated syndrome or mild multiple sclerosis and healthy controls: results from a prospective sonographer-blinded study.

PubMed

Chambers, Brian; Chambers, Jayne; Churilov, Leonid; Cameron, Heather; Macdonell, Richard

2014-09-01

We evaluated internal jugular vein and vertebral vein volume flow using ultrasound, in patients with clinically isolated syndrome or mild multiple sclerosis and controls, to determine whether volume flow was different between the two groups. In patients and controls, internal jugular vein volume flow increased from superior to inferior segments, consistent with recruitment from collateral veins. Internal jugular vein and vertebral vein volume flow were greater on the right in supine and sitting positions. Internal jugular vein volume flow was higher in the supine posture. Vertebral vein volume flow was higher in the sitting posture. Regression analyses of cube root transformed volume flow data, adjusted for supine/sitting, right/left and internal jugular vein/vertebral vein, revealed no significant difference in volume flow in patients compared to controls. Our findings further refute the concept of venous obstruction as a causal factor in the pathogenesis of multiple sclerosis. Control volume flow data may provide useful normative reference values. © The Author(s) 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow.

PubMed

Holter, Karl Erik; Kehlet, Benjamin; Devor, Anna; Sejnowski, Terrence J; Dale, Anders M; Omholt, Stig W; Ottersen, Ole Petter; Nagelhus, Erlend Arnulf; Mardal, Kent-André; Pettersen, Klas H

2017-09-12

The brain lacks lymph vessels and must rely on other mechanisms for clearance of waste products, including amyloid [Formula: see text] that may form pathological aggregates if not effectively cleared. It has been proposed that flow of interstitial fluid through the brain's interstitial space provides a mechanism for waste clearance. Here we compute the permeability and simulate pressure-mediated bulk flow through 3D electron microscope (EM) reconstructions of interstitial space. The space was divided into sheets (i.e., space between two parallel membranes) and tunnels (where three or more membranes meet). Simulation results indicate that even for larger extracellular volume fractions than what is reported for sleep and for geometries with a high tunnel volume fraction, the permeability was too low to allow for any substantial bulk flow at physiological hydrostatic pressure gradients. For two different geometries with the same extracellular volume fraction the geometry with the most tunnel volume had [Formula: see text] higher permeability, but the bulk flow was still insignificant. These simulation results suggest that even large molecule solutes would be more easily cleared from the brain interstitium by diffusion than by bulk flow. Thus, diffusion within the interstitial space combined with advection along vessels is likely to substitute for the lymphatic drainage system in other organs.

Effects of coil closure of patent ductus arteriosus on left anterior descending coronary artery blood flow using transthoracic Doppler echocardiography.

PubMed

Harada, Kenji; Toyono, Manotomo; Tamura, Masamichi

2004-06-01

Transthoracic Doppler echocardiography provides noninvasive measurements of coronary blood flow in the left anterior descending coronary artery (LAD). This method has the potential to show the effects of acute changes in loading conditions on blood flow. Coil closure of patent ductus arteriosus (PDA) is a model of acute changes in blood pressure and left ventricular (LV) preload that influences coronary blood flow. We applied this technique to assess the coronary blood flow changes for patients with PDA before and immediately after PDA coil closure. We examined 9 patients (1.8 +/- 1.1 years) with simple PDA and 8 age-matched healthy children. LV dimensions and LV mass were measured. Maximum peak flow velocity and flow volume in the LAD were measured. Pulmonary to systemic flow ratios (Qp/Qs) were obtained by cardiac catheterization. After PDA coil closure, LV end-diastolic dimension decreased, and systolic and diastolic blood pressures increased significantly. The maximum peak flow velocity, LAD flow volume, and the ratio of LAD flow volume to LV mass increased significantly. The changes in maximum peak flow velocity and the ratio of LAD flow volume to LV mass (F/M) correlated positively with the changes in diastolic pressure and Qp/Qs. In 5 patients who had Qp/Qs > 1.5, the mean F/M was significantly lower compared with control subjects, but they increased to normal values after coil closure of PDA. PDA coil closure increases diastolic pressure and decreases Qp/Qs, resulting in improvement of myocardial perfusion. These findings provide new insights into the relationship between cardiac function and coronary circulation in pediatric patients with heart diseases associated with PDA.

Understanding Gully Formation and Seasonal Flows on Recent and Current Mars

NASA Astrophysics Data System (ADS)

Gulick, Virginia C.; Glines, Natalie

2016-10-01

The discoveries of gullies and seasonal slope flows (RSL) have re-ignited the debate over various channel, valley, and gully formation mechanisms on Mars. The controversy over whether liquid water was involved with gully formation, harkens back to the mid-1970s to early 2000s, where catastrophic flooding, surface runnoff and ground-water sapping processes were strongly debated along with other mechanisms as the primary processes responsible for channel and valley formation on Mars. However, over the past decade, the value of multiple working hypotheses has again become apparent, this time in understanding the formation of Martian gullies and Recurring Slope Lineae. Various mechanisms put forth to explain these landforms include liquid H2O/ice erosion, CO2 ice/frost sublimation, CO2 ice block sliding, water and brine flows, salt deliquescence, and dry granular flows, among others.We carried out detailed morphologic/morphometric studies of gullies in various environmental settings on Mars to evaluate the potential formation processes. Using HiRISE images and DTMs, we mapped and generated detailed longitudinal and cross-sectional profiles of gully systems and estimated volumes for both the gullies and their debris aprons. Several gullies form highly integrated patterns similar to fluvial systems. Additionally, RSL are often found either in the tributaries of these integrated systems or in adjacent regions, implying that RSL may play a role in initiating gully formation or mark the last vestiges of water activity in these locations. We also find that the more highly integrated gullies have volumes significantly larger than their aprons, suggesting that the missing volumes (~40-60% or more) were likely the volatiles involved in gully formation. Additionally, THEMIS and TES surface temperatures of these integrated gully sites, many of which also contain RSL, are at or above freezing seasonally suggesting that the volatile component may be consistent with H2O although CO2 cannot be ruled out. Other less integrated systems have apron volumes that equal or exceed the gully volumes suggesting that dry flows, avalanching, gully infill, or other dry processes may have been more important in these environments.

Simulating Fiber Ordering and Aggregation In Shear Flow Using Dissipative Particle Dynamics

NASA Astrophysics Data System (ADS)

Stimatze, Justin T.

We have developed a mesoscale simulation of fiber aggregation in shear flow using LAMMPS and its implementation of dissipative particle dynamics. Understanding fiber aggregation in shear flow and flow-induced microstructural fiber networks is critical to our interest in high-performance composite materials. Dissipative particle dynamics enables the consideration of hydrodynamic interactions between fibers through the coarse-grained simulation of the matrix fluid. Correctly simulating hydrodynamic interactions and accounting for fluid forces on the microstructure is required to correctly model the shear-induced aggregation process. We are able to determine stresses, viscosity, and fiber forces while simulating the evolution of a model fiber system undergoing shear flow. Fiber-fiber contact interactions are approximated by combinations of common pairwise forces, allowing the exploration of interaction-influenced fiber behaviors such as aggregation and bundling. We are then able to quantify aggregate structure and effective volume fraction for a range of relevant system and fiber-fiber interaction parameters. Our simulations have demonstrated several aggregate types dependent on system parameters such as shear rate, short-range attractive forces, and a resistance to relative rotation while in contact. A resistance to relative rotation at fiber-fiber contact points has been found to strongly contribute to an increased angle between neighboring aggregated fibers and therefore an increase in average aggregate volume fraction. This increase in aggregate volume fraction is strongly correlated with a significant enhancement of system viscosity, leading us to hypothesize that controlling the resistance to relative rotation during manufacturing processes is important when optimizing for desired composite material characteristics.

Laminar, turbulent, and inertial shear-thickening regimes in channel flow of neutrally buoyant particle suspensions.

PubMed

Lashgari, Iman; Picano, Francesco; Breugem, Wim-Paul; Brandt, Luca

2014-12-19

The aim of this Letter is to characterize the flow regimes of suspensions of finite-size rigid particles in a viscous fluid at finite inertia. We explore the system behavior as a function of the particle volume fraction and the Reynolds number (the ratio of flow and particle inertia to viscous forces). Unlike single-phase flows, where a clear distinction exists between the laminar and the turbulent states, three different regimes can be identified in the presence of a particulate phase, with smooth transitions between them. At low volume fractions, the flow becomes turbulent when increasing the Reynolds number, transitioning from the laminar regime dominated by viscous forces to the turbulent regime characterized by enhanced momentum transport by turbulent eddies. At larger volume fractions, we identify a new regime characterized by an even larger increase of the wall friction. The wall friction increases with the Reynolds number (inertial effects) while the turbulent transport is weakly affected, as in a state of intense inertial shear thickening. This state may prevent the transition to a fully turbulent regime at arbitrary high speed of the flow.

Development of the Seeding System Used for Laser Velocimeter Surveys of the NASA Low-Speed Centrifugal Compressor Flow Field

NASA Technical Reports Server (NTRS)

Wasserbauer, C. A.; Hathaway, M. D.

1994-01-01

Consideration is given to an atomizer-based system for distributing high-volume rates of polystyrene latex (PSL) seed material developed to support laser velocimeter investigations of the NASA Low-Speed Compressor flow field. Complete evaporation of the liquid carrier before the flow entering the compressor was of primary concern for the seeder system design. It is argued that the seed nozzle should incorporate a needle valve that can mechanically dislodge accumulated PSL seed material when the nozzle is turned off. Water is less expensive as the liquid carrier and should be used whenever adequate residence times are available to ensure complete evaporation. PSL agglomerates over time and needs to be mixed or blended before use. Arrangement of the spray nozzles needs to be adjustable to provide maximum seeding at the laser probe volume.

Operationally Efficient Propulsion System Study (OEPSS) data book. Volume 1: Generic ground operations data

NASA Technical Reports Server (NTRS)

Byrd, Raymond J.

1990-01-01

This study was initiated to identify operations problems and cost drivers for current propulsion systems and to identify technology and design approaches to increase the operational efficiency and reduce operations costs for future propulsion systems. To provide readily usable data for the Advance Launch System (ALS) program, the results of the Operationally Efficient Propulsion System Study (OEPSS) were organized into a series of OEPSS Data Books as follows: Volume 1, Generic Ground Operations Data; Volume 2, Ground Operations Problems; Volume 3, Operations Technology; Volume 4, OEPSS Design Concepts; and Volume 5, OEPSS Final Review Briefing, which summarizes the activities and results of the study. This volume presents ground processing data for a generic LOX/LH2 booster and core propulsion system based on current STS experience. The data presented includes: top logic diagram, process flow, activities bar-chart, loaded timelines, manpower requirements in terms of duration, headcount and skill mix per operations and maintenance instruction (OMI), and critical path tasks and durations.

Use of a turbine in a breath-by-breath computer-based respiratory measurement system.

PubMed

Venkateswaran, R S; Gallagher, R R

1997-01-01

The Computer-Based Respiratory Measurement System (CBRMS) is capable of analyzing individual breaths to monitor the kinetics of oxygen uptake, carbon dioxide production, tidal volumes, pulmonary ventilation, and other respiratory parameters during rest, exercise, and recovery. Respiratory gas volumes are measured by a calibrated turbine transducer while the respiratory gas concentrations are measured by a calibrated, fast-responding medical gas analyzer. To improve accuracy of the results, the inspiratory volumes and gas concentrations are measured and not assumed to be equal to expiratory volumes or ambient concentrations respectively. The respiratory gas volumes and concentration signals are digitized and stored in arrays. The gas volumes are converted to flow signals by software differentiation. These digitized data arrays are stored as files in a personal computer. Time alignment of the flow and gas concentration signals is performed at each breath for maximum accuracy in analysis. For system verification, data were obtained under resting conditions and under constant load exercises at 50 W, 100 W, and 150 W. These workloads were performed by a healthy, male subject on a bicycle ergometer. A strong correlation existed between the CBRMS steady-state results and the standard end-expirate bag collection technique. Thus, there is reason to believe that the CBRMS is capable of calculating respiratory transient responses accurately, a significant contribution to an understanding of total respiratory system function.

Influence of georeference for saturated excess overland flow modelling using 3D volumetric soft geo-objects

NASA Astrophysics Data System (ADS)

Izham, Mohamad Yusoff; Muhamad Uznir, Ujang; Alias, Abdul Rahman; Ayob, Katimon; Wan Ruslan, Ismail

2011-04-01

Existing 2D data structures are often insufficient for analysing the dynamism of saturation excess overland flow (SEOF) within a basin. Moreover, all stream networks and soil surface structures in GIS must be preserved within appropriate projection plane fitting techniques known as georeferencing. Inclusion of 3D volumetric structure of the current soft geo-objects simulation model would offer a substantial effort towards representing 3D soft geo-objects of SEOF dynamically within a basin by visualising saturated flow and overland flow volume. This research attempts to visualise the influence of a georeference system towards the dynamism of overland flow coverage and total overland flow volume generated from the SEOF process using VSG data structure. The data structure is driven by Green-Ampt methods and the Topographic Wetness Index (TWI). VSGs are analysed by focusing on spatial object preservation techniques of the conformal-based Malaysian Rectified Skew Orthomorphic (MRSO) and the equidistant-based Cassini-Soldner projection plane under the existing geodetic Malaysian Revised Triangulation 1948 (MRT48) and the newly implemented Geocentric Datum for Malaysia (GDM2000) datum. The simulated result visualises deformation of SEOF coverage under different georeference systems via its projection planes, which delineate dissimilar computation of SEOF areas and overland flow volumes. The integration of Georeference, 3D GIS and the saturation excess mechanism provides unifying evidence towards successful landslide and flood disaster management through envisioning the streamflow generating process (mainly SEOF) in a 3D environment.

Tree water storage and its diurnal dynamics related to sap flow and changes in stem volume in old-growth Douglas-fir trees.

PubMed

Cermák, Jan; Kucera, Jiri; Bauerle, William L; Phillips, Nathan; Hinckley, Thomas M

2007-02-01

Diurnal and seasonal tree water storage was studied in three large Douglas-fir (Pseudotsuga menziesii [Mirb.] Franco) trees at the Wind River Canopy Crane Research site. Changes in water storage were based on measurements of sap flow and changes in stem volume and tissue water content at different heights in the stem and branches. We measured sap flow by two variants of the heat balance method (with internal heating in stems and external heating in branches), stem volume with electronic dendrometers, and tissue water content gravimetrically. Water storage was calculated from the differences in diurnal courses of sap flow at different heights and their integration. Old-growth Douglas-fir trees contained large amounts of free water: stem sapwood was the most important storage site, followed by stem phloem, branch sapwood, branch phloem and needles. There were significant time shifts (minutes to hours) between sap flow measured at different positions within the transport system (i.e., stem base to shoot tip), suggesting a highly elastic transport system. On selected fine days between late July and early October, when daily transpiration ranged from 150 to 300 liters, the quantity of stored water used daily ranged from 25 to 55 liters, i.e., about 20% of daily total sap flow. The greatest amount of this stored water came from the lower stem; however, proportionally more water was removed from the upper parts of the tree relative to their water storage capacity. In addition to lags in sap flow from one point in the hydrolic pathway to another, the withdrawal and replacement of stored water was reflected in changes in stem volume. When point-to-point lags in sap flow (minutes to hours near the top and stem base, respectively) were considered, there was a strong linear relationship between stem volume changes and transpiration. Volume changes of the whole tree were small (equivalent to 14% of the total daily use of stored water) indicating that most stored water came from the stem and from its inelastic (sapwood) tissues. Whole tree transpiration can be maintained with stored water for about a week, but it can be maintained with stored water from the upper crown alone for no more than a few hours.

Droplet-based magnetically activated cell separation: analysis of separation efficiency based on the variation of flow-induced circulation in a pendent drop.

PubMed

Kim, Youngho; Lee, Sang Ho; Kim, Byungkyu

2009-12-01

Under the assumption that separation efficiencies are mainly affected by the velocity of flow-induced circulation due to buffer injection in a pendent drop, this paper describes an analysis of the separation efficiency of a droplet-based magnetically activated cell separation (DMACS) system. To investigate the velocity of the flow-induced circulation, we supposed that numerous flows in a pendent drop could be considered as a "theoretically normalized" flow (or conceptually normalized flow, CNF) based on the Cauchy-Goursat theorem. With the morphological characteristics (length and duration time) of a pendent drop depending on the initial volume, we obtained the velocities of the CNF. By measuring the separation efficiencies for different initial volumes and by analyzing the separation efficiency in terms of the velocity of the CNF, we found that the separation efficiencies (in the case of a low rate of buffer injection; 5 and 15 microl x min(-1)) are mainly affected by the velocity of the CNF. Moreover, we confirmed that the phenomenological features of a pendent drop cause a fluctuation of its separation efficiencies over a range of specific volumes (initial volumes ranging from 40 to 80 microl), because of the "sweeping-off" phenomenon, that is, positive cells gathered into the positive fraction are forced to move away from the magnetic side by flow-induced circulation due to buffer injection. In addition, from the variation of the duration time, that is, the interval between the beginning of injection of the buffer solution and the time at which a pendent drop detaches, it could also be confirmed that a shorter duration time leads to decrease of the number of positive cells in negative fraction regardless of the rate of buffer injection (5, 15, and 50 microl x min(-1)). Therefore, if a DMACS system is operated with a 15 microl x min(-1) buffer injection flow rate and an initial volume of 80 microl or more, we would have the best efficiency of separation in the negative fraction.

Nonlinear-regression flow model of the Gulf Coast aquifer systems in the south-central United States

USGS Publications Warehouse

Kuiper, L.K.

1994-01-01

A multiple-regression methodology was used to help answer questions concerning model reliability, and to calibrate a time-dependent variable-density ground-water flow model of the gulf coast aquifer systems in the south-central United States. More than 40 regression models with 2 to 31 regressions parameters are used and detailed results are presented for 12 of the models. More than 3,000 values for grid-element volume-averaged head and hydraulic conductivity are used for the regression model observations. Calculated prediction interval half widths, though perhaps inaccurate due to a lack of normality of the residuals, are the smallest for models with only four regression parameters. In addition, the root-mean weighted residual decreases very little with an increase in the number of regression parameters. The various models showed considerable overlap between the prediction inter- vals for shallow head and hydraulic conductivity. Approximate 95-percent prediction interval half widths for volume-averaged freshwater head exceed 108 feet; for volume-averaged base 10 logarithm hydraulic conductivity, they exceed 0.89. All of the models are unreliable for the prediction of head and ground-water flow in the deeper parts of the aquifer systems, including the amount of flow coming from the underlying geopressured zone. Truncating the domain of solution of one model to exclude that part of the system having a ground-water density greater than 1.005 grams per cubic centimeter or to exclude that part of the systems below a depth of 3,000 feet, and setting the density to that of freshwater does not appreciably change the results for head and ground-water flow, except for locations close to the truncation surface.

Automated Cell-Cutting for Cell Cloning

NASA Astrophysics Data System (ADS)

Ichikawa, Akihiko; Tanikawa, Tamio; Matsukawa, Kazutsugu; Takahashi, Seiya; Ohba, Kohtaro

We develop an automated cell-cutting technique for cell cloning. Animal cells softened by the cytochalasin treatment are injected into a microfluidic chip. The microfluidic chip contains two orthogonal channels: one microchannel is wide, used to transport cells, and generates the cutting flow; the other is thin and used for aspiration, fixing, and stretching of the cell. The injected cell is aspirated and stretched in the thin microchannel. Simultaneously, the volumes of the cell before and after aspiration are calculated; the volumes are used to calculate the fluid flow required to aspirate half the volume of the cell into the thin microchannel. Finally, we apply a high-speed flow in the orthogonal microchannel to bisect the cell. This paper reports the cutting process, the cutting system, and the results of the experiment.

Increased dry season water yield in burned watersheds in Southern California

NASA Astrophysics Data System (ADS)

Kinoshita, Alicia M.; Hogue, Terri S.

2015-01-01

The current work evaluates the effects of the 2003 Old Fire on semi-arid systems in the San Bernardino Mountains, California. Pre- and post-fire daily streamflow are used to analyze flow regimes in two burned watersheds. The average pre-fire runoff ratios in Devil Canyon and City Creek are 0.14 and 0.26, respectively, and both increase to 0.34 post-fire. Annual flow duration curves are developed for each watershed and the low flow is characterized by a 90% exceedance probability threshold. Post-fire low flow is statistically different from the pre-fire values (α = 0.05). In Devil Canyon the annual volume of pre-fire low flow increases on average from 2.6E + 02 to 3.1E + 03 m3 (1090% increase) and in City Creek the annual low flow volume increases from 2.3E + 03 to 5.0E + 03 m3 (118% increase). Predicting burn system resilience to disturbance (anthropogenic and natural) has significant implications for water sustainability and ultimately may provide an opportunity to utilize extended and increased water yield.

Fluid dynamic analysis of a continuous stirred tank reactor for technical optimization of wastewater digestion.

PubMed

Hurtado, F J; Kaiser, A S; Zamora, B

2015-03-15

Continuous stirred tank reactors (CSTR) are widely used in wastewater treatment plants to reduce the organic matter and microorganism present in sludge by anaerobic digestion. The present study carries out a numerical analysis of the fluid dynamic behaviour of a CSTR in order to optimize the process energetically. The characterization of the sludge flow inside the digester tank, the residence time distribution and the active volume of the reactor under different criteria are determined. The effects of design and power of the mixing system on the active volume of the CSTR are analyzed. The numerical model is solved under non-steady conditions by examining the evolution of the flow during the stop and restart of the mixing system. An intermittent regime of the mixing system, which kept the active volume between 94% and 99%, is achieved. The results obtained can lead to the eventual energy optimization of the mixing system of the CSTR. Copyright © 2014 Elsevier Ltd. All rights reserved.

Urban Stormwater Runoff: A New Class of Environmental Flow Problem

PubMed Central

Walsh, Christopher J.; Fletcher, Tim D.; Burns, Matthew J.

2012-01-01

Environmental flow assessment frameworks have begun to consider changes to flow regimes resulting from land-use change. Urban stormwater runoff, which degrades streams through altered volume, pattern and quality of flow, presents a problem that challenges dominant approaches to stormwater and water resource management, and to environmental flow assessment. We used evidence of ecological response to different stormwater drainage systems to develop methods for input to environmental flow assessment. We identified the nature of hydrologic change resulting from conventional urban stormwater runoff, and the mechanisms by which such hydrologic change is prevented in streams where ecological condition has been protected. We also quantified the increase in total volume resulting from urban stormwater runoff, by comparing annual streamflow volumes from undeveloped catchments with the volumes that would run off impervious surfaces under the same rainfall regimes. In catchments with as little as 5–10% total imperviousness, conventional stormwater drainage, associated with poor in-stream ecological condition, reduces contributions to baseflows and increases the frequency and magnitude of storm flows, but in similarly impervious catchments in which streams retain good ecological condition, informal drainage to forested hillslopes, without a direct piped discharge to the stream, results in little such hydrologic change. In urbanized catchments, dispersed urban stormwater retention measures can potentially protect urban stream ecosystems by mimicking the hydrologic effects of informal drainage, if sufficient water is harvested and kept out of the stream, and if discharged water is treated to a suitable quality. Urban stormwater is a new class of environmental flow problem: one that requires reduction of a large excess volume of water to maintain riverine ecological integrity. It is the best type of problem, because solving it provides an opportunity to solve other problems such as the provision of water for human use. PMID:23029257

Efficient low static-volume water heater

NASA Technical Reports Server (NTRS)

Brown, R. L.

1976-01-01

Calrod heating element is surrounded by matrix of fused sintered copper or brass balls, and assembly is then installed in piping of water system. As water flows through matrix, sintered balls cause turbulent flow and heating. Applications include laundromats, laboratories, and photographic labs.

Cavitation enhances coagulated size during pulsed high-intensity focussed ultrasound ablation in an isolated liver perfusion system.

PubMed

Zhao, Lu-Yan; Liu, Shan; Chen, Zong-Gui; Zou, Jian-Zhong; Wu, Feng

2016-11-24

To investigate whether cavitation enhances the degree of coagulation during pulsed high-intensity focussed ultrasound (HIFU) in an isolated liver perfusion system. Isolated liver was treated by pulsed HIFU or continuous-wave HIFU with different portal vein flow rates. The cavitation emission during exposure was recorded, and real-time ultrasound images were used to observe changes in the grey scale. The coagulation size was measured and calculated. HIFU treatment led to complete coagulation necrosis and total cell destruction in the target regions. Compared to exposure at a duty cycle (DC) of 100%, the mean volumes of lesions induced by 6 s exposure at DCs of 50% and 10% were significantly larger (P < .01) but were smaller at a DC of 5%. The necrosis volume was negatively related to the perfusion rate in the pulsed HIFU at a DC of 50% for exposure durations of 4 and 6 s, while the perfusion flow rate did not affect the necrosis volume for exposure durations of 1, 2 and 3 s. For increased perfusion flow rates, there was no significant decrease in the cavitation activity for the pulsed-HIFU (P > .05). For continuous-wave HIFU exposure, there was a significant decrease in the necrosis volume and cavitation activity for exposure times of 1, 2, 3, 4, and 6 s with increasing portal perfusion rates. Perfusion flow rates negatively influence cavitation activity and coagulation volume. Ablation is significantly enhanced during pulsed HIFU exposure compared with continuous-wave HIFU.

A bioreactor system for the nitrogen loop in a Controlled Ecological Life Support System

NASA Technical Reports Server (NTRS)

Saulmon, M. M.; Reardon, K. F.; Sadeh, W. Z.

1996-01-01

As space missions become longer in duration, the need to recycle waste into useful compounds rises dramatically. This problem can be addressed by the development of Controlled Ecological Life Support Systems (CELSS) (i.e., Engineered Closed/Controlled Eco-Systems (ECCES)), consisting of human and plant modules. One of the waste streams leaving the human module is urine. In addition to the reclamation of water from urine, recovery of the nitrogen is important because it is an essential nutrient for the plant module. A 3-step biological process for the recycling of nitrogenous waste (urea) is proposed. A packed-bed bioreactor system for this purpose was modeled, and the issues of reaction step segregation, reactor type and volume, support particle size, and pressure drop were addressed. Based on minimization of volume, a bioreactor system consisting of a plug flow immobilized urease reactor, a completely mixed flow immobilized cell reactor to convert ammonia to nitrite, and a plug flow immobilized cell reactor to produce nitrate from nitrite is recommended. It is apparent that this 3-step bioprocess meets the requirements for space applications.

Compact 3D Camera for Shake-the-Box Particle Tracking

NASA Astrophysics Data System (ADS)

Hesseling, Christina; Michaelis, Dirk; Schneiders, Jan

2017-11-01

Time-resolved 3D-particle tracking usually requires the time-consuming optical setup and calibration of 3 to 4 cameras. Here, a compact four-camera housing has been developed. The performance of the system using Shake-the-Box processing (Schanz et al. 2016) is characterized. It is shown that the stereo-base is large enough for sensible 3D velocity measurements. Results from successful experiments in water flows using LED illumination are presented. For large-scale wind tunnel measurements, an even more compact version of the system is mounted on a robotic arm. Once calibrated for a specific measurement volume, the necessity for recalibration is eliminated even when the system moves around. Co-axial illumination is provided through an optical fiber in the middle of the housing, illuminating the full measurement volume from one viewing direction. Helium-filled soap bubbles are used to ensure sufficient particle image intensity. This way, the measurement probe can be moved around complex 3D-objects. By automatic scanning and stitching of recorded particle tracks, the detailed time-averaged flow field of a full volume of cubic meters in size is recorded and processed. Results from an experiment at TU-Delft of the flow field around a cyclist are shown.

Flow cells for bioanalytical and bioprocess applications with optimized dynamic response and flow characteristics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lancaster, V.R.; Modlin, D.N.

1994-12-31

In this study, the authors present a method for design and characterization of flow cells developed for minimum flow volume and optimal dynamic response with a given central observation area. The dynamic response of a circular shaped dual ported flow cell was compared to that obtained from a flow cell whose optimized shape was determined using this method. In the optimized flow cell design, the flow rate at the nominal operating pressure increased by 50% whereas the flow cell volume was reduced by 70%. In addition, the dynamic response of the new flow cell was found to be 200% fastermore » than the circular flow cell. The fluid dynamic analysis included simple graphical techniques utilizing free stream vorticity functions and Hagen-Poiseuille relationships. The flow cell dynamic response was measured using a fluorescence detection system. The fluoresce in emission from a 400{micro}m spot located at the exit port was measured as a function of time after switching the input to the flow cell between fluorescent and non-fluorescent solutions. Analysis of results revealed the system could be reasonably characterized as a first order dynamic system. Although some evidence of second order behavior was also observed, it is reasonable to assume that a first order model will provide adequate predictive capability for many real world applications. Given a set of flow cell requirements, the methods presented in this study can be used to design and characterize flow cells with lower reagent consumption and reduced purging times. These improvements can be readily translated into reduced process times and/or lower usage of high cost reagents.« less

Tracer-monitored flow titrations.

PubMed

Sasaki, Milton K; Rocha, Diogo L; Rocha, Fábio R P; Zagatto, Elias A G

2016-01-01

The feasibility of implementing tracer-monitored titrations in a flow system is demonstrated. A dye tracer is used to estimate the instant sample and titrant volumetric fractions without the need for volume, mass or peak width measurements. The approach was applied to spectrophotometric flow titrations involving variations of sample and titrant flow-rates (i.e. triangle programmed technique) or concentration gradients established along the sample zone (i.e. flow injection system). Both strategies required simultaneous monitoring of two absorbing species, namely the titration indicator and the dye tracer. Mixing conditions were improved by placing a chamber with mechanical stirring in the analytical path aiming at to minimize diffusional effects. Unlike most of flow-based titrations, the innovation is considered as a true titration, as it does not require a calibration curve thus complying with IUPAC definition. As an application, acidity evaluation in vinegars involving titration with sodium hydroxide was selected. Phenolphthalein and brilliant blue FCF were used as indicator and dye tracer, respectively. Effects of sample volume, titrand/titrant concentrations and flow rates were investigated aiming at improved accuracy and precision. Results were reliable and in agreement with those obtained by a reference titration procedure. Copyright © 2015 Elsevier B.V. All rights reserved.

Sublithospheric flows in the mantle

NASA Astrophysics Data System (ADS)

Trifonov, V. G.; Sokolov, S. Yu.

2017-11-01

The estimated rates of upper mantle sublithospheric flows in the Hawaii-Emperor Range and Ethiopia-Arabia-Caucasus systems are reported. In the Hawaii-Emperor Range system, calculation is based on motion of the asthenospheric flow and the plate moved by it over the branch of the Central Pacific plume. The travel rate has been determined based on the position of variably aged volcanoes (up to 76 Ma) with respect to the active Kilauea Volcano. As for the Ethiopia-Arabia-Caucasus system, the age of volcanic eruptions (55-2.8 Ma) has been used to estimate the asthenospheric flow from the Ethiopian-Afar superplume in the northern bearing lines. Both systems are characterized by variations in a rate of the upper mantle flows in different epochs from 4 to 12 cm/yr, about 8 cm/yr on average. Analysis of the global seismic tomographic data has made it possible to reveal rock volumes with higher seismic wave velocities under ancient cratons; rocks reach a depth of more than 2000 km and are interpreted as detached fragments of the thickened continental lithosphere. Such volumes on both sides of the Atlantic Ocean were submerged at an average velocity of 0.9-1.0 cm/yr along with its opening. The estimated rates of the mantle flows clarify the deformation properties of the mantle and regulate the numerical models of mantle convection.

Flow-Cell-Induced Dispersion in Flow-through Absorbance Detection Systems: True Column Effluent Peak Variance.

PubMed

Dasgupta, Purnendu K; Shelor, Charles Phillip; Kadjo, Akinde Florence; Kraiczek, Karsten G

2018-02-06

Following a brief overview of the emergence of absorbance detection in liquid chromatography, we focus on the dispersion caused by the absorbance measurement cell and its inlet. A simple experiment is proposed wherein chromatographic flow and conditions are held constant but a variable portion of the column effluent is directed into the detector. The temporal peak variance (σ t,obs 2 ), which increases as the flow rate (F) through the detector decreases, is found to be well-described as a quadratic function of 1 / F . This allows the extrapolation of the results to zero residence time in the detector and thence the determination of the true variance of the peak prior to the detector (this includes contribution of all preceding components). This general approach should be equally applicable to detection systems other than absorbance. We also experiment where the inlet/outlet system remains the same but the path length is varied. This allows one to assess the individual contributions of the cell itself and the inlet/outlet system.to the total observed peak. The dispersion in the cell itself has often been modeled as a flow-independent parameter, dependent only on the cell volume. Except for very long path/large volume cells, this paradigm is simply incorrect.

The Aerothermodynamics of Aircraft Gas Turbine Engines

DTIC Science & Technology

1978-07-01

engine will deteriorate. 1.6.2 Experimental Testing It is easy to fall int9 the organiza- tional trap of four isolated groups . One group does the... Quasi -Dne-Dimensional Fluid Flows The First Law for a F1mdng System-- The Control Volume • . • The Channel Flow Equations Stagnation Properties...exit to control volume (Eq • 2. 14 . 2) CHAPTER TWO THERMODYNAMICS AND QUASI -ONE-DUlENSIONAL FLUID FLO’’{S 2.0 INTRODUCTION This chapter "ill be

A Full Automatic Device for Sampling Small Solution Volumes in Photometric Titration Procedure Based on Multicommuted Flow System

PubMed Central

Borges, Sivanildo S.; Vieira, Gláucia P.; Reis, Boaventura F.

2007-01-01

In this work, an automatic device to deliver titrant solution into a titration chamber with the ability to determine the dispensed volume of solution, with good precision independent of both elapsed time and flow rate, is proposed. A glass tube maintained at the vertical position was employed as a container for the titrant solution. Electronic devices were coupled to the glass tube in order to control its filling with titrant solution, as well as the stepwise solution delivering into the titration chamber. The detection of the titration end point was performed employing a photometer designed using a green LED (λ=545 nm) and a phototransistor. The titration flow system comprised three-way solenoid valves, which were assembled to allow that the steps comprising the solution container loading and the titration run were carried out automatically. The device for the solution volume determination was designed employing an infrared LED (λ=930 nm) and a photodiode. When solution volume delivered from proposed device was within the range of 5 to 105 μl, a linear relationship (R = 0.999) between the delivered volumes and the generated potential difference was achieved. The usefulness of the proposed device was proved performing photometric titration of hydrochloric acid solution with a standardized sodium hydroxide solution and using phenolphthalein as an external indicator. The achieved results presented relative standard deviation of 1.5%. PMID:18317510

The Tacitness of Tacitus. A Methodological Approach to European Thought. No. 46.

ERIC Educational Resources Information Center

Bierschenk, Bernhard

This study measured the analysis of verbal flows by means of volume-elasticity measures and the analysis of information flow structures and their representations in the form of a metaphysical cube. A special purpose system of computer programs (PERTEX) was used to establish the language space in which the textual flow patterns occurred containing…

The Accuracy and Precision of Flow Measurements Using Phase Contrast Techniques

NASA Astrophysics Data System (ADS)

Tang, Chao

Quantitative volume flow rate measurements using the magnetic resonance imaging technique are studied in this dissertation because the volume flow rates have a special interest in the blood supply of the human body. The method of quantitative volume flow rate measurements is based on the phase contrast technique, which assumes a linear relationship between the phase and flow velocity of spins. By measuring the phase shift of nuclear spins and integrating velocity across the lumen of the vessel, we can determine the volume flow rate. The accuracy and precision of volume flow rate measurements obtained using the phase contrast technique are studied by computer simulations and experiments. The various factors studied include (1) the partial volume effect due to voxel dimensions and slice thickness relative to the vessel dimensions; (2) vessel angulation relative to the imaging plane; (3) intravoxel phase dispersion; (4) flow velocity relative to the magnitude of the flow encoding gradient. The partial volume effect is demonstrated to be the major obstacle to obtaining accurate flow measurements for both laminar and plug flow. Laminar flow can be measured more accurately than plug flow in the same condition. Both the experiment and simulation results for laminar flow show that, to obtain the accuracy of volume flow rate measurements to within 10%, at least 16 voxels are needed to cover the vessel lumen. The accuracy of flow measurements depends strongly on the relative intensity of signal from stationary tissues. A correction method is proposed to compensate for the partial volume effect. The correction method is based on a small phase shift approximation. After the correction, the errors due to the partial volume effect are compensated, allowing more accurate results to be obtained. An automatic program based on the correction method is developed and implemented on a Sun workstation. The correction method is applied to the simulation and experiment results. The results show that the correction significantly reduces the errors due to the partial volume effect. We apply the correction method to the data of in vivo studies. Because the blood flow is not known, the results of correction are tested according to the common knowledge (such as cardiac output) and conservation of flow. For example, the volume of blood flowing to the brain should be equal to the volume of blood flowing from the brain. Our measurement results are very convincing.

Theoretical Evaluation of Electroactive Polymer Based Micropump Diaphragm for Air Flow Control

NASA Technical Reports Server (NTRS)

Xu, Tian-Bing; Su, Ji; Zhang, Qiming

2004-01-01

An electroactive polymer (EAP), high energy electron irradiated poly(vinylidene fluoride-trifluoroethylene) [P(VDFTrFE)] copolymer, based actuation micropump diaphragm (PAMPD) have been developed for air flow control. The displacement strokes and profiles as a function of amplifier and frequency of electric field have been characterized. The volume stroke rates (volume rate) as function of electric field, driving frequency have been theoretically evaluated, too. The PAMPD exhibits high volume rate. It is easily tuned with varying of either amplitude or frequency of the applied electric field. In addition, the performance of the diaphragms were modeled and the agreement between the modeling results and experimental data confirms that the response of the diaphragms follow the design parameters. The results demonstrated that the diaphragm can fit some future aerospace applications to replace the traditional complex mechanical systems, increase the control capability and reduce the weight of the future air dynamic control systems. KEYWORDS: Electroactive polymer (EAP), micropump, diaphragm, actuation, displacement, volume rate, pumping speed, clamping ratio.

Stopped-flow enzyme assays on a chip using a microfabricated mixer.

PubMed

Burke, Brian J; Regnier, Fred E

2003-04-15

This paper describes a microfabricated enzyme assay system including a micromixer that can be used to perform stopped-flow reactions. Samples and reagents were transported into the system by electroosmotic flow (EOF). Streams of reagents were merged and passed through the 100-pL micromixer in < 1 s. The objective of the work was to perform kinetically based enzyme assays in the stopped-flow mode using a system of roughly 6 nL volume. Beta-galactosidase (beta-Gal) was chosen as a model enzyme for these studies and was used to convert the substrate fluorescein mono-beta-D-galactopyranoside (FMG) into fluorescein. Results obtained with microfabricated systems using the micromixer compared well to those obtained with an external T mixing device. In contrast, assays performed in a microfabricated device by merging two streams and allowing mixing to occur by lateral diffusion did not compare well. Using the microfabricated mixer, Km and kcat values of 75 +/- 13 microM and 44 +/- 3 s(-1) were determined. These values compare well to those obtained with the conventional stopped-flow apparatus for which Km was determined to be 60 +/- 6 microM and kcat was 47 +/- 4 s(-1). Enzyme inhibition assays with phenylethyl-beta-D-thiogalactoside (PETG) were also comparable. It was concluded that kinetically based, stopped-flow enzyme assays can be performed in 60 s or less with a miniaturized system of roughly 6 nL liquid volume when mixing is assisted with the described device.

Acoustic sand detector for fluid flowstreams

DOEpatents

Beattie, Alan G.; Bohon, W. Mark

1993-01-01

The particle volume and particle mass production rate of particulate solids entrained in fluid flowstreams such as formation sand or fracture proppant entrained in oil and gas production flowstreams is determined by a system having a metal probe interposed in a flow conduit for transmitting acoustic emissions created by particles impacting the probe to a sensor and signal processing circuit which produces discrete signals related to the impact of each of the particles striking the probe. The volume or mass flow rate of particulates is determined from making an initial particle size distribution and particle energy distribution and comparing the initial energy distribution and/or the initial size distribution with values related to the impact energies of a predetermined number of recorded impacts. The comparison is also used to recalibrate the system to compensate for changes in flow velocity.

Thermal Analysis of a Carbon Fiber Rope Barrier for Use in the Reusable Solid Rocket Motor Nozzle Joint-2

NASA Technical Reports Server (NTRS)

Clayton, J. Louie

2002-01-01

This study provides development and verification of analysis methods used to assess performance of a carbon fiber rope (CFR) thermal barrier system that is currently being qualified for use in Reusable Solid Rocket Motor (RSRM) nozzle joint-2. Modeled geometry for flow calculations considers the joint to be vented with the porous CFR barriers placed in the 'open' assembly gap. Model development is based on a 1-D volume filling approach where flow resistances (assembly gap and CFRs) are defined by serially connected internal flow and the porous media 'Darcy' relationships. Combustion gas flow rates are computed using the volume filling code by assuming a lumped distribution total joint fill volume on a per linear circumferential inch basis. Gas compressibility, friction and heat transfer are included in the modeling. Gas-to-wall heat transfer is simulated by concurrent solution of the compressible flow equations and a large thermal 2-D finite element (FE) conduction grid. The derived numerical technique loosely couples the FE conduction matrix with the compressible gas flow equations. Free constants that appear in the governing equations are calibrated by parametric model comparison to hot fire subscale test results. The calibrated model is then used to make full-scale motor predictions using RSRM aft dome environments. Model results indicate that CFR thermal barrier systems will provide a thermally benign and controlled pressurization environment for the RSRM nozzle joint-2 primary seal activation.

Thermal Analysis of a Carbon Fiber Rope Barrier for Use in the Reusable Solid Rocket Motor Nozzle Joint-2

NASA Technical Reports Server (NTRS)

Clayton, J. Louie; Phelps, Lisa (Technical Monitor)

2001-01-01

This study provides for development and verification of analysis methods used to assess performance of a carbon fiber rope (CFR) thermal barrier system that is currently being qualified for use in Reusable Solid Rocket Motor (RSRM) nozzle joint-2. Modeled geometry for flow calculations considers the joint to be vented with the porous CFR barriers placed in the "open' assembly gap. Model development is based on a 1-D volume filling approach where flow resistances (assembly gap and CFRs) are defined by serially connected internal flow and the porous media "Darcy" relationships. Combustion gas flow rates are computed using the volume filling code by assuming a lumped distribution total joint fill volume on a per linear circumferential inch basis. Gas compressibility, friction and heat transfer are included in the modeling. Gas-to-wall heat transfer is simulated by concurrent solution of the compressible flow equations and a large thermal 2-D finite element (FE) conduction grid. The derived numerical technique loosely couples the FE conduction matrix with the compressible gas flow equations, Free constants that appear in the governing equations are calibrated by parametric model comparison to hot fire subscale test results. The calibrated model is then used to make full-scale motor predictions using RSRM aft dome environments. Model results indicate that CFR thermal barrier systems will provide a thermally benign and controlled pressurization environment for the RSRM nozzle joint-2 primary seal activation.

Volume-Of-Fluid Simulation for Predicting Two-Phase Cooling in a Microchannel

NASA Astrophysics Data System (ADS)

Gorle, Catherine; Parida, Pritish; Houshmand, Farzad; Asheghi, Mehdi; Goodson, Kenneth

2014-11-01

Two-phase flow in microfluidic geometries has applications of increasing interest for next generation electronic and optoelectronic systems, telecommunications devices, and vehicle electronics. While there has been progress on comprehensive simulation of two-phase flows in compact geometries, validation of the results in different flow regimes should be considered to determine the predictive capabilities. In the present study we use the volume-of-fluid method to model the flow through a single micro channel with cross section 100 × 100 μm and length 10 mm. The channel inlet mass flux and the heat flux at the lower wall result in a subcooled boiling regime in the first 2.5 mm of the channel and a saturated flow regime further downstream. A conservation equation for the vapor volume fraction, and a single set of momentum and energy equations with volume-averaged fluid properties are solved. A reduced-physics phase change model represents the evaporation of the liquid and the corresponding heat loss, and the surface tension is accounted for by a source term in the momentum equation. The phase change model used requires the definition of a time relaxation parameter, which can significantly affect the solution since it determines the rate of evaporation. The results are compared to experimental data available from literature, focusing on the capability of the reduced-physics phase change model to predict the correct flow pattern, temperature profile and pressure drop.

Neural Control of the Cardiovascular System in Space

NASA Technical Reports Server (NTRS)

Levine, Benjamin D.; Pawelczyk, James A.; Zuckerman, Julie; Zhang, Rong; Fu, Qi; Iwasaki, Kenichi; Ray, Chet; Blomqvist, C. Gunnar; Lane, Lynda D.; Giller, Cole A.

2003-01-01

During the acute transition from lying supine to standing upright, a large volume of blood suddenly moves from the chest into the legs. To prevent fainting, the blood pressure control system senses this change immediately, and rapidly adjusts flow (by increasing heart rate) and resistance to flow (by constricting the blood vessels) to restore blood pressure and maintain brain blood flow. If this system is inadequate, the brain has a backup plan. Blood vessels in the brain can adjust their diameter to keep blood flow constant. If blood pressure drops, the brain blood vessels dilate; if blood pressure increases, the brain blood vessels constrict. This process, which is called autoregulation, allows the brain to maintain a steady stream of oxygen, even when blood pressure changes. We examined what changes in the blood pressure control system or cerebral autoregulation contribute to the blood pressure control problems seen after spaceflight. We asked: (1) does the adaptation to spaceflight cause an adaptation in the blood pressure control system that impairs the ability of the system to constrict blood vessels on return to Earth?; (2) if such a defect exists, could we pinpoint the neural pathways involved?; and (3) does cerebral autoregulation become abnormal during spaceflight, impairing the body s ability to maintain constant brain blood flow when standing upright on Earth? We stressed the blood pressure control system using lower body negative pressure, upright tilt, handgrip exercise, and cold stimulation of the hand. Standard cardiovascular parameters were measured along with sympathetic nerve activity (the nerve activity causing blood vessels to constrict) and brain blood flow. We confirmed that the primary cardiovascular effect of spaceflight was a postflight reduction in upright stroke volume (the amount of blood the heart pumps per beat). Heart rate increased appropriately for the reduction in stroke volume, thereby showing that changes in heart rate regulation alone cannot be responsible for orthostatic hypotension after spaceflight. All of the astronauts in our study had an increase in sympathetic nerve activity during upright tilting on Earth postflight. This increase was well calibrated for the reduction in stroke volume induced by the upright posture. The results obtained from stimulating the sympathetic nervous system using handgrip exercise or cold stress were also entirely normal during and after spaceflight. No astronaut had reduced cerebral blood flow during upright tilt, and cerebral autoregulation was normal or even enhanced inflight. These experiments show that the cardiovascular adaptation to spaceflight does not lead to a defect in the regulation of blood vessel constriction via sympathetic nerve activity. In addition, cerebral autoregulation is well-maintained. It is possible that despite the increased sympathetic nerve activity, blood vessels did not respond with a greater degree of constriction than occurred preflight, possibly uncovering a limit of vasoconstrictor reserve.

Gaseous oxygen uptake in porous media at different moisture contents and airflow velocities.

PubMed

Sharma, Prabhakar; Poulsen, Tjalfe G; Kalluri, Prasad N V

2009-06-01

The presence and distribution of water in the pore space is a critical factor for flow and transport of gases through unsaturated porous media. The water content also affects the biological activity necessary for treatment of polluted gas streams in biofilters. In this research, microbial activity and quantity of inactive volume in a porous medium as a function of moisture content and gas flow rate were investigated. Yard waste compost was used as a test medium, and oxygen uptake rate measurements were used to quantify microbial activity and effective active compost volume using batch and column flow-through systems. Compost water contents were varied from air-dry to field capacity and gas flows ranged from 0.2 to 2 L x min(-1). The results showed that overall microbial activity and the relative fraction of active compost medium volume increased with airflow velocity for all levels of water content up to a certain flow rate above which the oxygen uptake rate assumed a constant value independent of gas flow. The actual value of the maximum oxygen uptake rate was controlled by the water content. The oxygen uptake rate also increased with increasing water content and reached a maximum between 42 and 48% volumetric water content, above which it decreased, again likely because of formation of inactive zones in the compost medium. Overall, maximum possible oxygen uptake rate as a function of gas flow rate across all water contents and gas flows could be approximated by a linear expression. The relative fraction of active volume also increased with gas flow rate and reached approximately 80% for the highest gas flows used.

Changes in cochlear blood flow in mice due to loud sound exposure measured with Doppler optical microangiography and laser Doppler flowmetry.

PubMed

Reif, Roberto; Zhi, Zhongwei; Dziennis, Suzan; Nuttall, Alfred L; Wang, Ruikang K

2013-10-01

In this work we determined the contributions of loud sound exposure (LSE) on cochlear blood flow (CoBF) in an in vivo anesthetized mouse model. A broadband noise system (20 kHz bandwidth) with an intensity of 119 dB SPL, was used for a period of one hour to produce a loud sound stimulus. Two techniques were used to study the changes in blood flow, a Doppler optical microangiography (DOMAG) system; which can measure the blood flow within individual cochlear vessels, and a laser Doppler flowmetry (LDF) system; which averages the blood flow within a volume (a hemisphere of ~1.5 mm radius) of tissue. Both systems determined that the blood flow within the cochlea is reduced due to the LSE stimulation.

Design and nonlinear modeling of a sensitive sensor for the measurement of flow in mice.

PubMed

Bou Jawde, Samer; Smith, Bradford J; Sonnenberg, Adam; Bates, Jason H T; Suki, Bela

2018-06-07

While many studies rely on flow and pressure measurements in small animal models of respiratory disease, such measurements can however be inaccurate and difficult to obtain. Thus, the goal of this study was to design and implement an easy to manufacture and accurate sensor capable of monitoring flow. We designed and 3-D printed a flowmeter and utilized parametric (resistance and inertance) and nonparametric (polynomial and Volterra series) system identification to characterize the device. The sensor was tested in a closed system for apparent flow using the common mode rejection ratio (CMRR). The sensor properly measured tidal volumes and respiratory rates in spontaneously breathing mice. The device was used to evaluate a ventilator's ability to deliver a prescribed volume before and after lung injury. The parametric and polynomial models provided a reasonable prediction of the independently measured flow (Coefficient of determination (Cv)=0.9591 and 0.9147 respectively), but the Volterra series of the 1st, 2nd, and 3rd order with a memory of six time points provided better fits (Cv=0.9775, 0.9787, and 0.9954, respectively). At and below the mouse breathing frequency (1-5 Hz), CMRR was higher than 40 dB. Following lung injury, the sensor revealed a significant drop in delivered tidal volume. We demonstrate that the application of nonparametric nonlinear Volterra series modeling in combination with 3-D printing technology allows the inexpensive and rapid fabrication of an accurate flow sensor for continuously measuring small flows in various physiological conditions. © 2018 Institute of Physics and Engineering in Medicine.

Split Space-Marching Finite-Volume Method for Chemically Reacting Supersonic Flow

NASA Technical Reports Server (NTRS)

Rizzi, Arthur W.; Bailey, Harry E.

1976-01-01

A space-marching finite-volume method employing a nonorthogonal coordinate system and using a split differencing scheme for calculating steady supersonic flow over aerodynamic shapes is presented. It is a second-order-accurate mixed explicit-implicit procedure that solves the inviscid adiabatic and nondiffusive equations for chemically reacting flow in integral conservation-law form. The relationship between the finite-volume and differential forms of the equations is examined and the relative merits of each discussed. The method admits initial Cauchy data situated on any arbitrary surface and integrates them forward along a general curvilinear coordinate, distorting and deforming the surface as it advances. The chemical kinetics term is split from the convective terms which are themselves dimensionally split, thereby freeing the fluid operators from the restricted step size imposed by the chemical reactions and increasing the computational efficiency. The accuracy of this splitting technique is analyzed, a sufficient stability criterion is established, a representative flow computation is discussed, and some comparisons are made with another method.

Raised cerebrovascular resistance in idiopathic orthostatic intolerance: evidence for sympathetic vasoconstriction

NASA Technical Reports Server (NTRS)

Jordan, J.; Shannon, J. R.; Black, B. K.; Paranjape, S. Y.; Barwise, J.; Robertson, D.

1998-01-01

Patients with idiopathic orthostatic intolerance (IOI) exhibit symptoms suggestive of cerebral hypoperfusion and an excessive decrease in cerebral blood flow associated with standing despite sustained systemic blood pressure. In 9 patients (8 women and 1 man aged 22 to 48 years) with IOI, we tested the hypothesis that volume loading (2000 cc normal saline) and alpha-adrenoreceptor agonism improve systemic hemodynamics and cerebral perfusion and that the decrease in cerebral blood flow with head-up tilt (HUT) could be attenuated by alpha-adrenoreceptor blockade with phentolamine. At 5 minutes of HUT, volume loading (-20+/-3.2 bpm) and phenylephrine (-18+/-3.4 bpm) significantly reduced upright heart rate compared with placebo; the effect was diminished at the end of HUT. Phentolamine substantially increased upright heart rate at 5 minutes (20+/-3.7 bpm) and at the end of HUT (14+/-5 bpm). With placebo, mean cerebral blood flow velocity decreased by 33+/-6% at the end of HUT. This decrease in cerebral blood flow with HUT was attenuated by all 3 interventions. We conclude that in patients with IOI, HUT causes a substantial decrease in cerebrovascular blood flow velocity. The decrease in blood flow velocity with HUT can be attenuated with interventions that improve systemic hemodynamics and therefore decrease reflex sympathetic activation. Moreover, alpha-adrenoreceptor blockade also blunts the decrease in cerebral blood flow with HUT but at the price of deteriorated systemic hemodynamics. These observations may suggest that in patients with IOI, excessive sympathetic activity contributes to the paradoxical decrease in cerebral blood flow with upright posture.

ASRDI oxygen technology survey. Volume 6: Flow measurement instrumentation

NASA Technical Reports Server (NTRS)

Mann, D. B.

1974-01-01

A summary is provided of information available on liquid and gaseous oxygen flowmetering including an evaluation of commercial meters. The instrument types, physical principles of measurement, and performance characteristics are described. Problems concerning flow measurements of less than plus or minus two percent uncertainty are reviewed. Recommendations concerning work on flow reference systems, the use of surrogate fluids, and standard tests for oxygen flow measurements are also presented.

Design of Training Systems, Phase II Report, Volume III; Model Program Descriptions and Operating Procedures. TAEG Report No. 12-2.

ERIC Educational Resources Information Center

Naval Training Equipment Center, Orlando, FL. Training Analysis and Evaluation Group.

The Design of Training Systems (DOTS) project was initiated by the Department of Defense (DOD) to develop tools for the effective management of military training organizations. Volume 3 contains the model and data base program descriptions and operating procedures designed for phase 2 of the project. Flow charts and program listings for the…

Variable volume combustor with aerodynamic support struts

DOEpatents

Ostebee, Heath Michael; Johnson, Thomas Edward; Stewart, Jason Thurman; Keener, Christopher Paul

2017-03-07

The present application provides a combustor for use with a gas turbine engine. The combustor may include a number of micro-mixer fuel nozzles and a fuel injection system for providing a flow of fuel to the micro-mixer fuel nozzles. The fuel injection system may include a number of support struts supporting the fuel nozzles and providing the flow of fuel therethrough. The support struts may include an aerodynamic contoured shape so as to distribute evenly a flow of air to the micro-mixer fuel nozzles.

High performance spiral wound microbial fuel cell with hydraulic characterization.

PubMed

Haeger, Alexander; Forrestal, Casey; Xu, Pei; Ren, Zhiyong Jason

2014-12-01

The understanding and development of functioning systems are crucial steps for microbial fuel cell (MFC) technology advancement. In this study, a compact spiral wound MFC (swMFC) was developed and hydraulic residence time distribution (RTD) tests were conducted to investigate the flow characteristics in the systems. Results show that two-chamber swMFCs have high surface area to volume ratios of 350-700m(2)/m(3), and by using oxygen cathode without metal-catalysts, the maximum power densities were 42W/m(3) based on total volume and 170W/m(3) based on effective volume. The hydraulic step-input tracer study identified 20-67% of anodic flow dead space, which presents new opportunities for system improvement. Electrochemical tools revealed very low ohmic resistance but high charge transfer and diffusion resistance due to catalyst-free oxygen reduction. The spiral wound configuration combined with RTD tool offers a holistic approach for MFC development and optimization. Copyright © 2014 Elsevier Ltd. All rights reserved.

Characteristics of an axisymmetric sudden expansion flow

NASA Technical Reports Server (NTRS)

Stevenson, W. H.; Thompson, H. D.

1985-01-01

A two-color, two component Laser Doppler Velocimeter (LDV) system operating in forward scatter has been developed in order to make simultaneous measurements of the axial and radial velocity components in an axisymmetric sudden expansion flow with and without combustion. The LDV system includes Bragg cell modulators in the four beam paths to allow a net frequency shift of 5MHz in both the green and blue beams. This permits an unambiguous measurement of negative velocities and also eliminates incomplete signal bias. The green beam probe volume has a waist diameter of 0.200 mm and is approximately 2mm long. The blue beam has a probe volume waist of 0.250 mm and is approximately 1 mm long. The scattered light from the probe volume is separated so that approximately 80% of each color passes to its respective photomultiplier tube by using a dichroic filter. Narrow bandpass filters are used to further filter unwanted signals before they are detected. A schematic diagram of the LDV system is shown.

Erosion and deposition on a debris-flow fan

NASA Astrophysics Data System (ADS)

Densmore, A. L.; Schuerch, P.; Rosser, N. J.; McArdell, B. W.

2011-12-01

The ability of a debris flow to entrain or deposit sediment controls the downstream evolution of flow volume, and ultimately dictates both the geomorphic impact of the flow and the potential hazard that it represents. Our understanding of the patterns of, and controls on, such flow volume changes remains extremely limited, however, partly due to a poor mechanistic grasp of the interactions between debris flows and their bed and banks. In addition, we lack a good understanding of the cumulative long-term effects of sequences of flows in a single catchment-fan system. Here we begin to address these issues by using repeated terrestrial laser scanning (TLS) to characterize the detailed surface change associated with the passage of multiple debris flows on the Illgraben fan, Switzerland. We calculate surface elevation change along a 300 m study reach, and from this derive the downfan rate of flow volume change, or lag rate; for comparison, we also derive the spatially-averaged lag rate over the entire ~2 km length of the fan. Lag rates are broadly comparable over both length scales, indicating that flow behavior does not vary significantly across the fan for most flows, but importantly we find that flow volume at the fan head is a poor predictor of volume at the fan toe. The sign and magnitude of bed elevation change scale with local flow depth; at flow depths < 2 m, erosion and deposition are approximately equally likely, but erosion becomes increasingly dominant for flow depths > 2 m. On the Illgraben fan, this depth corresponds to a basal shear stress of 3-4 kPa. Because flow depth is in part a function of channel cross-sectional topography, which varies strongly both within and between flows, this result indicates that erosion and deposition are likely to be highly dynamic. The dependence of flow volume change on both the channel topography and the flow history may thus complicate efforts to predict debris-flow inundation areas by simple flow routing. We then apply a 2d numerical model of debris-flow fan evolution to explore the key controls on debris-flow routing and topographic development over sequences of multiple flows. We find that fan topographic roughness plays an important role in both channel development and fan surface stability. We also find that, while first-order fan shape is largely insensitive to the input flow sequence, second-order variables such as the pattern of surface exposure ages and the distribution of channel characteristics hold more promise as robust recorders of past flow conditions. Further work is needed to understand the degree to which the TLS-derived (and Illgraben-specific) relationship between bed elevation change and flow depth can be applied in different settings, and to elucidate the role played by coarse debris in controlling patterns of erosion and deposition.

Dispersion of a Nanoliter Bolus in Microfluidic Co-Flow.

PubMed

Conway, A J; Saadi, W M; Sinatra, F L; Kowalski, G; Larson, D; Fiering, J

2014-03-01

Microfluidic systems enable reactions and assays on the scale of nanoliters. However, at this scale nonuniformities in sample delivery become significant. To determine the fundamental minimum sample volume required for a particular device, a detailed understanding of mass transport is required. Co-flowing laminar streams are widely used in many devices, but typically only in the steady-state. Because establishing the co-flow steady-state consumes excess sample volume and time, there is a benefit to operating devices in the transient state, which predominates as the volume of the co-flow reactor decreases. Analysis of the co-flow transient has been neglected thus far. In this work we describe the fabrication of a pneumatically controlled microfluidic injector constructed to inject a discrete 50nL bolus into one side of a two-stream co-flow reactor. Using dye for image analysis, injections were performed at a range of flow rates from 0.5-10μL/min, and for comparison we collected the co-flow steady-state data for this range. The results of the image analysis were also compared against theory and simulations for device validation. For evaluation, we established a metric that indicates how well the mass distribution in the bolus injection approximates steady-state co-flow. Using such analysis, transient-state injections can approximate steady-state conditions within predefined errors, allowing straight forward measurements to be performed with reduced reagent consumption.

Study of Plasma Flows Generated in Plasma Focus Discharge in Different Regimes of Working Gas Filling

NASA Astrophysics Data System (ADS)

Voitenko, D. A.; Ananyev, S. S.; Astapenko, G. I.; Basilaia, A. D.; Markolia, A. I.; Mitrofanov, K. N.; Myalton, V. V.; Timoshenko, A. P.; Kharrasov, A. M.; Krauz, V. I.

2017-12-01

Results are presented from experimental studies of the plasma flows generated in the KPF-4 Phoenix Mather-type plasma focus device (Sukhum Physical Technical Institute). In order to study how the formation and dynamics of the plasma flow depend on the initial distribution of the working gas, a system of pulsed gas puffing into the discharge volume was developed. The system allows one to create profiled gas distributions, including those with a reduced gas density in the region of plasma flow propagation. Results of measurements of the magnetic field, flow profile, and flow deceleration dynamics at different initial distributions of the gas pressure are presented.

Engine lubrication circuit including two pumps

DOEpatents

Lane, William H.

2006-10-03

A lubrication pump coupled to the engine is sized such that the it can supply the engine with a predetermined flow volume as soon as the engine reaches a peak torque engine speed. In engines that operate predominately at speeds above the peak torque engine speed, the lubrication pump is often producing lubrication fluid in excess of the predetermined flow volume that is bypassed back to a lubrication fluid source. This arguably results in wasted power. In order to more efficiently lubricate an engine, a lubrication circuit includes a lubrication pump and a variable delivery pump. The lubrication pump is operably coupled to the engine, and the variable delivery pump is in communication with a pump output controller that is operable to vary a lubrication fluid output from the variable delivery pump as a function of at least one of engine speed and lubrication flow volume or system pressure. Thus, the lubrication pump can be sized to produce the predetermined flow volume at a speed range at which the engine predominately operates while the variable delivery pump can supplement lubrication fluid delivery from the lubrication pump at engine speeds below the predominant engine speed range.

Storm Water Management Model Reference Manual Volume II ...

EPA Pesticide Factsheets

SWMM is a dynamic rainfall-runoff simulation model used for single event or long-term (continuous) simulation of runoff quantity and quality from primarily urban areas. The runoff component of SWMM operates on a collection of subcatchment areas that receive precipitation and generate runoff and pollutant loads. The routing portion of SWMM transports this runoff through a system of pipes, channels, storage/treatment devices, pumps, and regulators. SWMM tracks the quantity and quality of runoff generated within each subcatchment, and the flow rate, flow depth, and quality of water in each pipe and channel during a simulation period comprised of multiple time steps. The reference manual for this edition of SWMM is comprised of three volumes. Volume I describes SWMM’s hydrologic models, Volume II its hydraulic models, and Volume III its water quality and low impact development models. This document provides the underlying mathematics for the hydraulic calculations of the Storm Water Management Model (SWMM)

ASRDI Oxygen Technological Survey. Volume 9; Oxygen Systems Engineering Review

NASA Technical Reports Server (NTRS)

Schmidt, H. W.; Forney, D. E.

1975-01-01

The design and safe operation of O2 systems at high pressures and temperatures are discussed. Data cover O2 reactivity with system materials, environmental limits, flow rate, contamination, and physical and chemical stresses of materials.

A novel instrument for studying the flow behaviour of erythrocytes through microchannels simulating human blood capillaries.

PubMed

Sutton, N; Tracey, M C; Johnston, I D; Greenaway, R S; Rampling, M W

1997-05-01

A novel instrument has been developed to study the microrheology of erythrocytes as they flow through channels of dimensions similar to human blood capillaries. The channels are produced in silicon substrates using microengineering technology. Accurately defined, physiological driving pressures and temperatures are employed whilst precise, real-time image processing allows individual cells to be monitored continuously during their transit. The instrument characterises each cell in a sample of ca. 1000 in terms of its volume and flow velocity profile during its transit through a channel. The unique representation of the data in volume/velocity space provides new insight into the microrheological behaviour of blood. The image processing and subsequent data analysis enable the system to reject anomalous events such as multiple cell transits, thereby ensuring integrity of the resulting data. By employing an array of microfluidic flow channels we can integrate a number of different but precise and highly reproducible channel sizes and geometries within one array, thereby allowing multiple, concurrent isobaric measurements on one sample. As an illustration of the performance of the system, volume/velocity data sets recorded in a microfluidic device incorporating multiple channels of 100 microns length and individual widths ranging between 3.0 and 4.0 microns are presented.

Automation Applications in an Advance Air Traffic Management System : Volume IIB : Functional Analysis of Air Traffic Management (Cont'd)

DOT National Transportation Integrated Search

1974-08-01

Volume 2 contains the analysis and description of air traffic management activities at three levels of detail - functions, subfunctions, and tasks. A total of 265 tasks are identified and described, and the flow of information inputs and outputs amon...

Automated Applications in an Advanced Air Traffic Management System : Volume 2B. Functional Analysis of Air Traffic Management (Cont'd.)

DOT National Transportation Integrated Search

1974-08-01

Volume 2 contains the analysis and description of air traffic management activities at three levels of detail - functions, subfunctions, and tasks. A total of 265 tasks are identified and described, and the flow of information inputs and outputs amon...

Automation Applications in an Advanced Air Traffic Management System : Volume 2A. Functional Analysis of Air Traffic Management.

DOT National Transportation Integrated Search

1974-08-01

Volume 2 contains the analysis and description of air traffic management activities at three levels of detail - functions, subfunctions, and tasks. A total of 265 tasks are identified and described, and the flow of information inputs and outputs amon...

Automation Applications in an Advanced Air Traffic Management System : Volume 2C. Functional Analysis of Air Traffic Management (Cont.'d)

DOT National Transportation Integrated Search

1974-08-01

Volume 2 contains the analysis and description of air traffic management activities at three levels of detail - functions, subfunctions, and tasks. A total of 265 tasks are identified and described, and the flow of information inputs and outputs amon...

Design and performance of a large vocabulary discrete word recognition system. Volume 2: Appendixes. [flow charts and users manual

NASA Technical Reports Server (NTRS)

1973-01-01

The users manual for the word recognition computer program contains flow charts of the logical diagram, the memory map for templates, the speech analyzer card arrangement, minicomputer input/output routines, and assembly language program listings.

SST Technology Follow-on Program - Phase I, Performance Evaluation of an SST Noise Suppressor Nozzle System. Volume 1. Suppressed Mode.

DTIC Science & Technology

ACOUSTIC INSULATION, *TURBOJET EXHAUST NOZZLES, *JET ENGINE NOISE, REDUCTION, JET TRANSPORT AIRCRAFT, THRUST AUGMENTATION , SUPERSONIC NOZZLES, DUCT...INLETS, CONVERGENT DIVERGENT NOZZLES, SUBSONIC FLOW, SUPERSONIC FLOW, SUPPRESSORS, TURBOJET INLETS, BAFFLES, JET PUMPS, THRUST , DRAG, TEMPERATURE

A simple bubble-flowmeter with quasicontinuous registration.

PubMed

Ludt, H; Herrmann, H D

1976-07-22

The construction of a simple bubble-flow-meter is described. The instrument has the following features: 1. automatic bubble injection, 2. precise measurement of the bubble passage time by a digital counter, 3. quasicontinuous registration of the flow rate, 4. alternative run with clear fluid (water) and coloured fluid (blood), 5. low volume, 6. closed measuring system for measurements in low and high pressure systems.

Thermally developed peristaltic propulsion of magnetic solid particles in biorheological fluids

NASA Astrophysics Data System (ADS)

Bhatti, M. M.; Zeeshan, A.; Tripathi, D.; Ellahi, R.

2018-04-01

In this article, effects of heat and mass transfer on MHD peristaltic motion of solid particles in a dusty fluid are investigated. The effects of nonlinear thermal radiation and Hall current are also taken into account. The relevant flow analysis is modelled for fluid phase and dust phase in wave frame by means of Casson fluid model. Computation of solutions is presented for velocity profile, temperature profile and concentration profile. The effects of all the physical parameters such as particle volume fraction, Hartmann number, Hall Effect, Prandtl number, Eckert number, Schmidt number and Soret number are discussed mathematically and graphically. It is noted that the influence of magnetic field and particle volume fraction opposes the flow. Also, the impact of particle volume fraction is quite opposite on temperature and concentration profile. This model is applicable in smart drug delivery systems and bacteria movement in urine flow through the ureter.

Modular Exhaust Design and Manufacturing Techniques for Low Cost Mid Volume Rapid Buidl to Order Systems

DTIC Science & Technology

2014-08-06

the pressure field is uniform across them, but which allow mass flow to be diverted. Series elements have a constant mass flow across the ports...they can be used to calculate the pressure and mass flow after the element from the pressure and mass flow prior to the element, as shown in...the matrix product of each transfer matrix in turn. The final matrix gives no information about the pressures and mass flows within the element

C-arm flat detector computed tomography parenchymal blood volume imaging: the nature of parenchymal blood volume parameter and the feasibility of parenchymal blood volume imaging in aneurysmal subarachnoid haemorrhage patients.

PubMed

Kamran, Mudassar; Byrne, James V

2015-09-01

C-arm flat detector computed tomography (FDCT) parenchymal blood volume (PBV) measurements allow assessment of cerebral haemodynamics in the neurointerventional suite. This paper explores the feasibility of C-arm computed tomography (CT) PBV imaging and the relationship between the C-arm CT PBV and the MR-PWI-derived cerebral blood volume (CBV) and cerebral blood flow (CBF) parameters in aneurysmal subarachnoid haemorrhage (SAH) patients developing delayed cerebral ischemia (DCI). Twenty-six patients with DCI following aneurysmal SAH underwent a research C-arm CT PBV scan using a biplane angiography system and contemporaneous MR-PWI scan as part of a prospective study. Quantitative whole-brain atlas-based volume-of-interest analysis in conjunction with Pearson correlation and Bland-Altman tests was performed to explore the agreement between C-arm CT PBV and MR-derived CBV and CBF measurements. All patients received medical management, while eight patients (31%) underwent selective intra-arterial chemical angioplasty. Colour-coded C-arm CT PBV maps were 91% sensitive and 100% specific in detecting the perfusion abnormalities. C-arm CT rPBV demonstrated good agreement and strong correlation with both MR-rCBV and MR-rCBF measurements; the agreement and correlation were stronger for MR-rCBF relative to MR-rCBV and improved for C-arm CT PBV versus the geometric mean of MR-rCBV and MR-rCBF. Analysis of weighted means showed that the C-arm CT PBV has a preferential blood flow weighting (≈ 60% blood flow and ≈ 40% blood volume weighting). C-arm CT PBV imaging is feasible in DCI following aneurysmal SAH. PBV is a composite perfusion parameter incorporating both blood flow and blood volume weightings. That PBV has preferential (≈ 60%) blood flow weighting is an important finding, which is of clinical significance when interpreting the C-arm CT PBV maps, particularly in the setting of acute brain ischemia.

A computer model of the pediatric circulatory system for testing pediatric assist devices.

PubMed

Giridharan, Guruprasad A; Koenig, Steven C; Mitchell, Michael; Gartner, Mark; Pantalos, George M

2007-01-01

Lumped parameter computer models of the pediatric circulatory systems for 1- and 4-year-olds were developed to predict hemodynamic responses to mechanical circulatory support devices. Model parameters, including resistance, compliance and volume, were adjusted to match hemodynamic pressure and flow waveforms, pressure-volume loops, percent systole, and heart rate of pediatric patients (n = 6) with normal ventricles. Left ventricular failure was modeled by adjusting the time-varying compliance curve of the left heart to produce aortic pressures and cardiac outputs consistent with those observed clinically. Models of pediatric continuous flow (CF) and pulsatile flow (PF) ventricular assist devices (VAD) and intraaortic balloon pump (IABP) were developed and integrated into the heart failure pediatric circulatory system models. Computer simulations were conducted to predict acute hemodynamic responses to PF and CF VAD operating at 50%, 75% and 100% support and 2.5 and 5 ml IABP operating at 1:1 and 1:2 support modes. The computer model of the pediatric circulation matched the human pediatric hemodynamic waveform morphology to within 90% and cardiac function parameters with 95% accuracy. The computer model predicted PF VAD and IABP restore aortic pressure pulsatility and variation in end-systolic and end-diastolic volume, but diminish with increasing CF VAD support.

Integrative energy-systems design: System structure from thermodynamic optimization

NASA Astrophysics Data System (ADS)

Ordonez, Juan Carlos

This thesis deals with the application of thermodynamic optimization to find optimal structure and operation conditions of energy systems. Chapter 1 outlines the thermodynamic optimization of a combined power and refrigeration system subject to constraints. It is shown that the thermodynamic optimum is reached by distributing optimally the heat exchanger inventory. Chapter 2 considers the maximization of power extraction from a hot stream in the presence of phase change. It shows that when the receiving (cold) stream boils in a counterflow heat exchanger, the thermodynamic optimization consists of locating the optimal capacity rate of the cold stream. Chapter 3 shows that the main architectural features of a counterflow heat exchanger can be determined based on thermodynamic optimization subject to volume constraint. Chapter 4 addresses two basic issues in the thermodynamic optimization of environmental control systems (ECS) for aircraft: realistic limits for the minimal power requirement, and design features that facilitate operation at minimal power consumption. Several models of the ECS-Cabin interaction are considered and it is shown that in all the models the temperature of the air stream that the ECS delivers to the cabin can be optimized for operation at minimal power. In chapter 5 it is shown that the sizes (weights) of heat and fluid flow systems that function on board vehicles such as aircraft can be derived from the maximization of overall (system level) performance. Chapter 6 develops analytically the optimal sizes (hydraulic diameters) of parallel channels that penetrate and cool a volume with uniformly distributed internal heat generation and Chapter 7 shows analytically and numerically how an originally uniform flow structure transforms itself into a nonuniform one when the objective is to minimize global flow losses. It is shown that flow maldistribution and the abandonment of symmetry are necessary for the development of flow structures with minimal resistance. In the second part of the chapter, the flow medium is continuous and permeated by Darcy flow. As flow systems become smaller and more compact, the flow systems themselves become "designed porous media".

Gated CT imaging using a free-breathing respiration signal from flow-volume spirometry

DOE Office of Scientific and Technical Information (OSTI.GOV)

D'Souza, Warren D.; Kwok, Young; Deyoung, Chad

2005-12-15

Respiration-induced tumor motion is known to cause artifacts on free-breathing spiral CT images used in treatment planning. This leads to inaccurate delineation of target volumes on planning CT images. Flow-volume spirometry has been used previously for breath-holds during CT scans and radiation treatments using the active breathing control (ABC) system. We have developed a prototype by extending the flow-volume spirometer device to obtain gated CT scans using a PQ 5000 single-slice CT scanner. To test our prototype, we designed motion phantoms to compare image quality obtained with and without gated CT scan acquisition. Spiral and axial (nongated and gated) CTmore » scans were obtained of phantoms with motion periods of 3-5 s and amplitudes of 0.5-2 cm. Errors observed in the volume estimate of these structures were as much as 30% with moving phantoms during CT simulation. Application of motion-gated CT with active breathing control reduced these errors to within 5%. Motion-gated CT was then implemented in patients and the results are presented for two clinical cases: lung and abdomen. In each case, gated scans were acquired at end-inhalation, end-exhalation in addition to a conventional free-breathing (nongated) scan. The gated CT scans revealed reduced artifacts compared with the conventional free-breathing scan. Differences of up to 20% in the volume of the structures were observed between gated and free-breathing scans. A comparison of the overlap of structures between the gated and free-breathing scans revealed misalignment of the structures. These results demonstrate the ability of flow-volume spirometry to reduce errors in target volumes via gating during CT imaging.« less

Comprehensive integrated spirometry using raised volume passive and forced expirations and multiple-breath nitrogen washout in infants

PubMed Central

Morris, Mohy G.

2009-01-01

With the rapid somatic growth and development in infants, simultaneous accurate measurements of lung volume and airway function are essential. Raised volume rapid thoracoabdominal compression (RTC) is widely used to generate forced expiration from an airway opening pressure of 30 cm H2O (V30). The (dynamic) functional residual capacity (FRCdyn) remains the lung volume most routinely measured. The aim of this study was to develop comprehensive integrated spirometry that included all subdivisions of lung volume at V30 or total lung capacity (TLC30). Measurements were performed on seventeen healthy infants aged 8.6–119.7 weeks. A commercial system for multiple-breath nitrogen washout (MBNW) to measure lung volumes and a custom made system to perform RTC were used in unison. A refined automated raised volume RTC and the following two novel single maneuvers with dual volume measurements were performed from V30 during a brief post-hyperventilation apneic pause: (1) the passive expiratory flow was integrated to produce the inspiratory capacity (IC) and the static (passive) FRC (FRCst) was estimated by initiating MBNW after end-passive expiration; (2) RTC was initiated late during passive expiration, flow was integrated to produce the slow vital capacity (jSVC) and the residual volume (RV) was measured by initiating MBNW after end-expiration while the jacket (j) was inflated. Intrasubject FRCdyn and FRCst measurements overlapped (p= 0.6420) but neither did with the RV (p<0.0001). Means (95% confidence interval) of FRCdyn, IC, FRCst, jSVC, RV, forced vital capacity and tidal volume were 21.2 (19.7–22.7), 36.7 (33.0–40.4), 21.2 (19.6–22.8), 40.7 (37.2–44.2), 18.1 (16.6–19.7), 40.7 (37.1–44.2) and 10.2 (9.6–10.7) ml/kg, respectively. Static lung volumes and capacities at V30 and variables from the best forced expiratory flow-volume curve were dependent on age, body length and weight. In conclusion, we developed a comprehensive physiologically-integrated approach for in-depth investigation of lung function at V30 in infants. PMID:19897058

A Pulsatile Cardiovascular Computer Model for Teaching Heart-Blood Vessel Interaction.

ERIC Educational Resources Information Center

Campbell, Kenneth; And Others

1982-01-01

Describes a model which gives realistic predictions of pulsatile pressure, flow, and volume events in the cardiovascular system. Includes computer oriented laboratory exercises for veterinary and graduate students; equations of the dynamic and algebraic models; and a flow chart for the cardiovascular teaching program. (JN)

Flow-Control Unit For Nitrogen And Hydrogen Gases

NASA Technical Reports Server (NTRS)

Chang, B. J.; Novak, D. W.

1990-01-01

Gas-flow-control unit installed and removed as one piece replaces system that included nine separately serviced components. Unit controls and monitors flows of nitrogen and hydrogen gases. Designed for connection via fluid-interface manifold plate, reducing number of mechanical fluid-interface connections from 18 to 1. Unit provides increasing reliability, safety, and ease of maintenance, and for reducing weight, volume, and power consumption.

[Continuous low volume infusion of hydroxyethyl starch as an option of water balance correction in patients with gestosis].

PubMed

Zhurova, A A; Ekstrem, A V; Popov, A S

2010-01-01

The method of long-term continuous low-volume infusion of hydroxyethyl starch (low-flow low volume correction HES) is administrated for correction of fluid balance disorders. The method is aimed to improve the outcomes in preeclamsia patients with multiple organ dysfunction and failure, as the most severe manifestation of system inflammatory response syndrome. After 4 days of the intensive care with application of the developed method in patients with preeclamsia the total body water level is decreased to the normal physiological level, the oedemas are significantly reduced or ceased, the haemodynamics stabilizes, which leads to the reduce of neurologic symptoms. The suggested method of low-flow low volume correction HES, in dose of 15 ml/kg/day is a significant addition to the existing methods of homeostasis and preeclampsia correction.

Two-stage preconcentrator for vapor/particle detection

DOEpatents

Linker, Kevin L.; Brusseau, Charles A.

2002-01-01

A device for concentrating particles from a high volume gas stream and delivering the particles for detection in a low volume gas stream includes first and second preconcentrators. The first preconcentrator has a first structure for retaining particles in a first gas flow path through which a first gas flows at a relatively high volume, valves for selectively stopping the first gas flow; and a second gas flow path through which gas flows at an intermediate flow volume for moving particles from the first structure. The second preconcentrator includes a second structure for retaining particles in the second gas flow path; a valve for selectively stopping the second gas flow; and a third gas flow path through which gas flows at a low volume for moving particles from the second structure to a detector. Each of the particle retaining structures is preferably a metal screen that may be resistively heated by application of an electric potential to release the particles.

Determination of mercury by multisyringe flow injection system with cold-vapor atomic absorption spectrometry.

PubMed

Leal, L O; Elsholz, O; Forteza, R; Cerdà, V

2006-07-28

A new software-controlled time-based multisyringe flow injection system for mercury determination by cold-vapor atomic absorption spectrometry is proposed. Precise known volumes of sample, reducing agent (1.1% SnCl2 in 3% HCl) and carrier (3% HCl) are dispensed into a gas-liquid separation cell with a multisyringe burette coupled with one three-way solenoid valve. An argon flow delivers the reduced mercury to the spectrometer. The optimization of the system was carried out testing reaction coils and gas-liquid separators of different design as well as changing parameters, such as sample and reagents volumes, reagent concentrations and carrier gas flow rate, among others. The analytical curves were obtained within the range 50-5000 ng L(-1). The detection limit (3sigma(b)/S) achieved is 5 ng L(-1). The relative standard deviation (R.S.D.) was 1.4%, evaluated from 16 successive injections of 250 ng L(-1) Hg standard solution. The injection and sample throughput per hour were 44 and 11, respectively. This technique was validated by means of solid and water reference materials with good agreement with the certified values and was successfully applied to fish samples.

Modeling the Hydrologic Processes of a Permeable Pavement System

EPA Science Inventory

A permeable pavement system can capture stormwater to reduce runoff volume and flow rate, improve onsite groundwater recharge, and enhance pollutant controls within the site. A new unit process model for evaluating the hydrologic performance of a permeable pavement system has be...

Development of prototype decision support systems for real-time freeway traffic routing. Volume I.

DOT National Transportation Integrated Search

1998-01-01

For a traffic management system (TMS) to improve traffic flow, TMS operators must develop effective routing strategies based on the data collected by the system. The purpose of this research was to build prototype decision support systems (DSS) for t...

Empirical models to predict the volumes of debris flows generated by recently burned basins in the western U.S.

USGS Publications Warehouse

Gartner, J.E.; Cannon, S.H.; Santi, P.M.; deWolfe, V.G.

2008-01-01

Recently burned basins frequently produce debris flows in response to moderate-to-severe rainfall. Post-fire hazard assessments of debris flows are most useful when they predict the volume of material that may flow out of a burned basin. This study develops a set of empirically-based models that predict potential volumes of wildfire-related debris flows in different regions and geologic settings. The models were developed using data from 53 recently burned basins in Colorado, Utah and California. The volumes of debris flows in these basins were determined by either measuring the volume of material eroded from the channels, or by estimating the amount of material removed from debris retention basins. For each basin, independent variables thought to affect the volume of the debris flow were determined. These variables include measures of basin morphology, basin areas burned at different severities, soil material properties, rock type, and rainfall amounts and intensities for storms triggering debris flows. Using these data, multiple regression analyses were used to create separate predictive models for volumes of debris flows generated by burned basins in six separate regions or settings, including the western U.S., southern California, the Rocky Mountain region, and basins underlain by sedimentary, metamorphic and granitic rocks. An evaluation of these models indicated that the best model (the Western U.S. model) explains 83% of the variability in the volumes of the debris flows, and includes variables that describe the basin area with slopes greater than or equal to 30%, the basin area burned at moderate and high severity, and total storm rainfall. This model was independently validated by comparing volumes of debris flows reported in the literature, to volumes estimated using the model. Eighty-seven percent of the reported volumes were within two residual standard errors of the volumes predicted using the model. This model is an improvement over previous models in that it includes a measure of burn severity and an estimate of modeling errors. The application of this model, in conjunction with models for the probability of debris flows, will enable more complete and rapid assessments of debris flow hazards following wildfire.

Development of model-based control for Bridgman crystal growth

NASA Astrophysics Data System (ADS)

Sonda, Paul; Yeckel, Andrew; Daoutidis, Prodromos; Derby, Jeffrey. J.

2004-05-01

We study the feasibility of using crucible rotation with feedback control to suppress oscillatory flows in two prototypical vertical Bridgman crystal growth systems—a stabilizing configuration driven by a time-oscillatory furnace disturbance and a thermally destabilized configuration, which exhibits inherent time-varying flows. Proportional controllers are applied to the two systems, with volume-averaged flow speed chosen as the single controlled output and crucible rotation chosen as the manipulated input. Proportional control is able to significantly suppress oscillations in the stabilizing configuration. For the destabilized case, control is effective for small-amplitude flows but is generally ineffective, due to the exacerbating effect of crucible rotation on the time-dependent flows exhibited by this system.

NASTRAN hydroelastic modal studies. Volume 2: Programmer documentation

NASA Technical Reports Server (NTRS)

1977-01-01

The operational steps, data descriptions, and program code for the new NASTRAN hydroelastic analysis system are described. The overall flow of the system is described, followed by the descriptions of the individual modules and their subroutines.

Design and Performance of the Sorbent-Based Atmosphere Revitalization System for Orion

NASA Technical Reports Server (NTRS)

Ritter, James A.; Reynolds, Steven P.; Ebner, Armin D.; Knox, James C.; LeVan, M. Douglas

2007-01-01

Validation and simulations of a real-time dynamic cabin model were conducted on the sorbent-based atmosphere revitalization system for Orion. The dynamic cabin model, which updates the concentration of H2O and CO2 every second during the simulation, was able to predict the steady state model values for H2O and CO2 for long periods of steady metabolic production for a 4-person crew. It also showed similar trends for the exercise periods, where there were quick changes in production rates. Once validated, the cabin model was used to determine the effects of feed flow rate, cabin volume and column volume. A higher feed flow rate reduced the cabin concentrations only slightly over the base case, a larger cabin volume was able to reduce the cabin concentrations even further, and the lower column volume led to much higher cabin concentrations. Finally, the cabin model was used to determine the effect of the amount of silica gel in the column. As the amount increased, the cabin concentration of H2O decreased, but the cabin concentration of CO2 increased.

Perioperative fluid management: comparison of high, medium and low fluid volume on tissue oxygen pressure in the small bowel and colon.

PubMed

Hiltebrand, L B; Pestel, G; Hager, H; Ratnaraj, J; Sigurdsson, G H; Kurz, A

2007-11-01

Insufficient blood flow and oxygenation in the intestinal tract is associated with increased incidence of postoperative complications after bowel surgery. High fluid volume administration may prevent occult regional hypoperfusion and intestinal tissue hypoxia. We tested the hypothesis that high intraoperative fluid volume administration increases intestinal wall tissue oxygen pressure during laparotomy. In all, 27 pigs were anaesthetized, ventilated and randomly assigned to one of the three treatment groups (n = 9 in each) receiving low (3 mL kg-1 h-1), medium (7 mL kg-1 h-1) or high (20 mL kg-1 h-1) fluid volume treatment with lactated Ringer's solution. All animals received 30% and 100% inspired oxygen in random order. Cardiac index was measured with thermodilution and tissue oxygen pressure with a micro-oximetry system in the jejunum and colon wall and subcutaneous tissue. Groups receiving low and medium fluid volume treatment had similar systemic haemodynamics. The high fluid volume group had significantly higher mean arterial pressure, cardiac index and subcutaneous tissue oxygenation. Tissue oxygen pressures in the jejunum and colon were comparable in all three groups. The three different fluid volume regimens tested did not affect tissue oxygen pressure in the jejunum and colon, suggesting efficient autoregulation of intestinal blood flow in healthy subjects undergoing uncomplicated abdominal surgery.

Empirical model for the volume-change behavior of debris flows

USGS Publications Warehouse

Cannon, S.H.; ,

1993-01-01

The potential travel down hillsides; movement stops where the volume-change behavior of flows as they travel down hillsides ; movement stops where the volume of actively flowing debris becomes negligible. The average change in volume over distance for 26 recent debris flows in the Honolulu area was assumed to be a function of the slope over which the debris flow traveled, the degree of flow confinement by the channel, and an assigned value for the type of vegetation through which the debris flow traveled. Analysis of the data yielded a relation that can be incorporated into digital elevation models to characterize debris-flow travel on Oahu.

Microspheres as resistive elements in a check valve for low pressure and low flow rate conditions.

PubMed

Ou, Kevin; Jackson, John; Burt, Helen; Chiao, Mu

2012-11-07

In this paper we describe a microsphere-based check valve integrated with a micropump. The check valve uses Ø20 μm polystyrene microspheres to rectify flow in low pressure and low flow rate applications (Re < 1). The microspheres form a porous medium in the check valve increasing fluidic resistance based on the direction of flow. Three check valve designs were fabricated and characterized to study the microspheres' effectiveness as resistive elements. A maximum diodicity (ratio of flow in the forward and reverse direction) of 18 was achieved. The pumping system can deliver a minimum flow volume of 0.25 μL and a maximum flow volume of 1.26 μL under an applied pressure of 0.2 kPa and 1 kPa, respectively. A proof-of-concept study was conducted using a pharmaceutical agent, docetaxel (DTX), as a sample drug showing the microsphere check valve's ability to limit diffusion from the micropump. The proposed check valve and pumping concept shows strong potential for implantable drug delivery applications with low flow rate requirements.

Upscaling the Navier-Stokes Equation for Turbulent Flows in Porous Media Using a Volume Averaging Method

NASA Astrophysics Data System (ADS)

Wood, Brian; He, Xiaoliang; Apte, Sourabh

2017-11-01

Turbulent flows through porous media are encountered in a number of natural and engineered systems. Many attempts to close the Navier-Stokes equation for such type of flow have been made, for example using RANS models and double averaging. On the other hand, Whitaker (1996) applied volume averaging theorem to close the macroscopic N-S equation for low Re flow. In this work, the volume averaging theory is extended into the turbulent flow regime to posit a relationship between the macroscale velocities and the spatial velocity statistics in terms of the spatial averaged velocity only. Rather than developing a Reynolds stress model, we propose a simple algebraic closure, consistent with generalized effective viscosity models (Pope 1975), to represent the spatial fluctuating velocity and pressure respectively. The coefficients (one 1st order, two 2nd order and one 3rd order tensor) of the linear functions depend on averaged velocity and gradient. With the data set from DNS, performed with inertial and turbulent flows (pore Re of 300, 500 and 1000) through a periodic face centered cubic (FCC) unit cell, all the unknown coefficients can be computed and the closure is complete. The macroscopic quantity calculated from the averaging is then compared with DNS data to verify the upscaling. NSF Project Numbers 1336983, 1133363.

A flow-simulation model of the tidal Potomac River

USGS Publications Warehouse

Schaffranek, Raymond W.

1987-01-01

A one-dimensional model capable of simulating flow in a network of interconnected channels has been applied to the tidal Potomac River including its major tributaries and embayments between Washington, D.C., and Indian Head, Md. The model can be used to compute water-surface elevations and flow discharges at any of 66 predetermined locations or at any alternative river cross sections definable within the network of channels. In addition, the model can be used to provide tidal-interchange flow volumes and to evaluate tidal excursions and the flushing properties of the riverine system. Comparisons of model-computed results with measured watersurface elevations and discharges demonstrate the validity and accuracy of the model. Tidal-cycle flow volumes computed by the calibrated model have been verified to be within an accuracy of ? 10 percent. Quantitative characteristics of the hydrodynamics of the tidal river are identified and discussed. The comprehensive flow data provided by the model can be used to better understand the geochemical, biological, and other processes affecting the river's water quality.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hurley, D.F.; Whitehouse, J.M.

A dedicated low-flow groundwater sample collection system was designed for implementation in a post-closure ACL monitoring program at the Yaworski Lagoon NPL site in Canterbury, Connecticut. The system includes dedicated bladder pumps with intake ports located in the screened interval of the monitoring wells. This sampling technique was implemented in the spring of 1993. The system was designed to simultaneously obtain samples directly from the screened interval of nested wells in three distinct water bearing zones. Sample collection is begun upon stabilization of field parameters. Other than line volume, no prior purging of the well is required. It was foundmore » that dedicated low-flow sampling from the screened interval provides a method of representative sample collection without the bias of suspended solids introduced by traditional techniques of pumping and bailing. Analytical data indicate that measured chemical constituents are representative of groundwater migrating through the screened interval. Upon implementation of the low-flow monitoring system, analytical results exhibited a decrease in concentrations of some organic compounds and metals. The system has also proven to be a cost effective alternative to pumping and bailing which generate large volumes of purge water requiring containment and disposal.« less

Measurements Of Coronary Mean Transit Time And Myocardial Tissue Blood Flow By Deconvolution Of Intravasal Tracer Dilution Curves

NASA Astrophysics Data System (ADS)

Korb, H.; Hoeft, A.; Hellige, G.

1984-10-01

Previous studies have shown that intramyocardial blood volume does not vary to a major extent even during extreme variation of hemodynamics and coronary vascular tone. Based on a constant intramyocardial blood volume it is therefore possible to calculate tissue blood flow from the mean transit time of an intravascular tracer. The purpose of this study was to develop a clinically applicable method for measurement of coronary blood flow. The new method was based on indocyanine green, a dye which is bound to albumin and intravasally detectable by means of a fiberoptic catheter device. One fiberoptic catheter was placed in the aortic root and another in the coronary sinus. After central venous dye injection the resulting arterial and coronary venous dye dilution curves were processed on-line by a micro-computer. The mean transit time as well as myocardial blood flow were calculated from the step response function of the deconvoluted arterial and coronary venous signals. Reference flow was determined with an extracorporeal electromagnetic flowprobe within a coronary sinus bypass system. 38 steady states with coronary blood flow ranging from 49 - 333 ml/min*100g were analysed in 5 dogs. Mean transit times varied from 2.9 to 16.6 sec. An average intracoronary blood volume of 13.9 -7 1.8 m1/100g was calculated. The correlation between flow determined by the dye dilution technique and flow measured with the reference method was 0.98. According to these results determination of coronary blood flow with a double fiberoptic system and indocyanine green should be possible even under clinical conditions. Furthermore, the arterial and coronary venous oxygen saturation can be monitored continuously by the fiberoptic catheters. Therefore, additional information about the performance of the heart such as myocardial oxygen consumption and myocardial efficiency is available with the same equipment.

Renal and Cardio-Endocrine Responses in Humans to Simulated Microgravity

NASA Technical Reports Server (NTRS)

Williams, Gordon H.

1999-01-01

The volume regulating systems are integrated to produce an appropriate response to both acute and chronic volume changes. Their responses include changing the levels of the hormones and neural inputs of the involved systems and/or changing the responsiveness of their target tissues. Weightlessness during space travel produces a volume challenge that is unfamiliar to the organism. Thus, it is likely that these volume regulatory mechanisms may respond inappropriately, e.g., a decrease in total body volume in space and abnormal responses to upright posture and stress on return to Earth. A similar "inappropriateness" also can occur in disease states, e.g., congestive heart failure. While it is clear that weightlessness produces profound changes in sodium and volume homeostasis, the mechanisms responsible for these changes are incompletely understood. Confounding this analysis is sleep deprivation, common in space travel, which can also modify volume homeostatic mechanisms. The purpose of this project is to provide the required understanding and then to design appropriate countermeasures to reduce or eliminate the adverse effects of microgravity. To accomplish this we are addressing five Specific Aims: (1) To test the hypothesis that microgravity modifies the acute responsiveness of the renin-angiotensin-aldosterone system (RAAS) and renal blood flow; (2) Does simulated microgravity change the circadian rhythm of the volume- regulating hormones?; (3) Does simulated microgravity change the target tissue responsiveness to angiotensin 11 (AngII)?; (4) Does chronic sleep deprivation modify the circadian rhythm of the RAAS and change the acute responsiveness of this system to posture beyond what a microgravity environment alone does? and (5) What effect does salt restriction have on the volume homeostatic and neurohumoral responses to a microgravity environment? Because the RAAS plays a pivotal role in blood pressure control and volume homeostasis, it likely is a major mediator of the adaptive cardio-renal responses observed during space missions and is a special focus of this project. Thus, the overall goal of this project is to assess the impact of microgravity and sleep deprivation in humans on volume-regulating systems. To achieve this overall objective, we are evaluating renal blood flow and the status and responsiveness of the volume- regulating systems (RAAS, atrial natriuretic peptide and vasopressin), and the adrenergic system (plasma and urine catecholamines) in both simulated microgravity and normal gravity with and -Without sleep deprivation. Furthermore, the responses of the volume homeostatic mechanisms to acute stimulation by upright tilt testing, standing and exercise are being evaluated before and after achieving equilibrium with these interventions.

On-site flow calibration of turbine meters for natural gas custody transfer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ting, V.C.; Schexnayder, L.L.; Conkling, D.B.

1991-05-01

This paper presents the design criteria, performance characteristics, and calibration procedures relating to a turbine-meter flow-calibration facility used in the high-volume custody transfer of natural gas. The facility, located in Venice, LA, is owned and operated by Chevron U.S.A. Inc. and is used to meter sales volumes of up to 500 MMscf/D (14.16 {times} 10 std m{sup 3}/d) at a nominal operating pressure of 1,000 psig (6.9 MPa). The system includes three 12-in. (30.48 cm) turbine meters used for sales-volume measurement, a bank of sonic nozzles, and a master turbine meter connected in series with the sales meters. The sonicmore » nozzles and master meter serve as flow-proving and -calibration devices. sonic nozzles are recommended by the turbine-meter standard for meter calibration. This paper examines the performance of on-site calibration of gas turbine meters. The Venice facility successfully demonstrated that on-site calibration of gas-metering devices can ensure accurate gas-flow measurement under field conditions.« less

Numerical Simulation of Blood Flow in Human Artery Using (A, Q) and (A, u) Systems

NASA Astrophysics Data System (ADS)

Mungkasi, Sudi; Wijayanti Budiawan, Inge

2018-03-01

In this paper, we model blood flow in human artery in the form of (𝐴, 𝑄) and (𝐴, 𝑢) systems, then we use the Lax-Friedrichs finite volume method to find the numerical solution of each model. Here 𝐴 represents the cross sectional area of the artery, 𝑄 denotes the discharge of the blood flow, and 𝑢 is the velocity of the blood flow. We simulate the numerical scheme of each model and investigate how the blood pressure pulse propagates in human artery. Particularly, we use the residual of 𝐴 to determine which system is better numerically. We obtain that the (𝐴, 𝑄) system is better numerically than the (𝐴, 𝑢) system, because the absolute of the residual of 𝐴 using the (𝐴, 𝑄) system is smaller than the absolute of the residual of 𝐴 using the (𝐴, 𝑢) system.

Vector velocity volume flow estimation: Sources of error and corrections applied for arteriovenous fistulas.

PubMed

Jensen, Jonas; Olesen, Jacob Bjerring; Stuart, Matthias Bo; Hansen, Peter Møller; Nielsen, Michael Bachmann; Jensen, Jørgen Arendt

2016-08-01

A method for vector velocity volume flow estimation is presented, along with an investigation of its sources of error and correction of actual volume flow measurements. Volume flow errors are quantified theoretically by numerical modeling, through flow phantom measurements, and studied in vivo. This paper investigates errors from estimating volumetric flow using a commercial ultrasound scanner and the common assumptions made in the literature. The theoretical model shows, e.g. that volume flow is underestimated by 15%, when the scan plane is off-axis with the vessel center by 28% of the vessel radius. The error sources were also studied in vivo under realistic clinical conditions, and the theoretical results were applied for correcting the volume flow errors. Twenty dialysis patients with arteriovenous fistulas were scanned to obtain vector flow maps of fistulas. When fitting an ellipsis to cross-sectional scans of the fistulas, the major axis was on average 10.2mm, which is 8.6% larger than the minor axis. The ultrasound beam was on average 1.5mm from the vessel center, corresponding to 28% of the semi-major axis in an average fistula. Estimating volume flow with an elliptical, rather than circular, vessel area and correcting the ultrasound beam for being off-axis, gave a significant (p=0.008) reduction in error from 31.2% to 24.3%. The error is relative to the Ultrasound Dilution Technique, which is considered the gold standard for volume flow estimation for dialysis patients. The study shows the importance of correcting for volume flow errors, which are often made in clinical practice. Copyright © 2016 Elsevier B.V. All rights reserved.

Determination of fractional flow reserve (FFR) based on scaling laws: a simulation study

NASA Astrophysics Data System (ADS)

Wong, Jerry T.; Molloi, Sabee

2008-07-01

Fractional flow reserve (FFR) provides an objective physiological evaluation of stenosis severity. A technique that can measure FFR using only angiographic images would be a valuable tool in the cardiac catheterization laboratory. To perform this, the diseased blood flow can be measured with a first pass distribution analysis and the theoretical normal blood flow can be estimated from the total coronary arterial volume based on scaling laws. A computer simulation of the coronary arterial network was used to gain a better understanding of how hemodynamic conditions and coronary artery disease can affect blood flow, arterial volume and FFR estimation. Changes in coronary arterial flow and volume due to coronary stenosis, aortic pressure and venous pressure were examined to evaluate the potential use of flow and volume for FFR determination. This study showed that FFR can be estimated using arterial volume and a scaling coefficient corrected for aortic pressure. However, variations in venous pressure were found to introduce some error in FFR estimation. A relative form of FFR was introduced and was found to cancel out the influence of pressure on coronary flow, arterial volume and FFR estimation. The use of coronary flow and arterial volume for FFR determination appears promising.

Development of an automated flow injection analysis system for determination of phosphate in nutrient solutions.

PubMed

Karadağ, Sevinç; Görüşük, Emine M; Çetinkaya, Ebru; Deveci, Seda; Dönmez, Koray B; Uncuoğlu, Emre; Doğu, Mustafa

2018-01-25

A fully automated flow injection analysis (FIA) system was developed for determination of phosphate ion in nutrient solutions. This newly developed FIA system is a portable, rapid and sensitive measuring instrument that allows on-line analysis and monitoring of phosphate ion concentration in nutrient solutions. The molybdenum blue method, which is widely used in FIA phosphate analysis, was adapted to the developed FIA system. The method is based on the formation of ammonium Mo(VI) ion by reaction of ammonium molybdate with the phosphate ion present in the medium. The Mo(VI) ion then reacts with ascorbic acid and is reduced to the spectrometrically measurable Mo(V) ion. New software specific for flow analysis was developed in the LabVIEW development environment to control all the components of the FIA system. The important factors affecting the analytical signal were identified as reagent flow rate, injection volume and post-injection flow path length, and they were optimized using Box-Behnken experimental design and response surface methodology. The optimum point for the maximum analytical signal was calculated as 0.50 mL min -1 reagent flow rate, 100 µL sample injection volume and 60 cm post-injection flow path length. The proposed FIA system had a sampling frequency of 100 samples per hour over a linear working range of 3-100 mg L -1 (R 2  = 0.9995). The relative standard deviation (RSD) was 1.09% and the limit of detection (LOD) was 0.34 mg L -1 . Various nutrient solutions from a tomato-growing hydroponic greenhouse were analyzed with the developed FIA system and the results were found to be in good agreement with vanadomolybdate chemical method findings. © 2018 Society of Chemical Industry. © 2018 Society of Chemical Industry.

Modelling the effects of on-site greywater reuse and low flush toilets on municipal sewer systems.

PubMed

Penn, R; Schütze, M; Friedler, E

2013-01-15

On-site greywater reuse (GWR) and installation of water-efficient toilets (WET) reduce urban freshwater demand. Research on GWR and WET has generally overlooked the effects that GWR may have on municipal sewer systems. This paper discusses and quantifies these effects. The effects of GWR and WET, positive and negative, were studied by modelling a representative urban sewer system. GWR scenarios were modelled and analysed using the SIMBA simulation system. The results show that, as expected, the flow, velocity and proportional depth decrease as GWR increases. Nevertheless, the reduction is not evenly distributed throughout the day but mainly occurs during the morning and evening peaks. Examination of the effects of reduced toilet flush volumes revealed that in some of the GWR scenarios flows, velocities and proportional depths in the sewer were reduced, while in other GWR scenarios discharge volumes, velocities and proportional depths did not change. Further, it is indicated that as a result of GWR and installation of WET, sewer blockage rates are not expected to increase significantly. The results support the option to construct new sewer systems with smaller pipe diameters. The analysis shows that as the penetration of GWR systems increase, and with the installation of WET, concentrations of pollutants also increase. In GWR scenarios (when toilet flush volume is not reduced) the increase in pollutant concentrations is lower than the proportional reduction of sewage flow. Moreover, the results show that the spatial distribution of houses reusing GW does not significantly affect the parameters examined. Copyright © 2012 Elsevier Ltd. All rights reserved.

Development of the seeding system used for laser velocimeter surveys of the NASA Low-Speed Centrifugal Compressor flow field

NASA Technical Reports Server (NTRS)

Wasserbauer, Charles A.; Hathaway, Michael D.

1993-01-01

An atomizer-based system for distributing high-volume rates of seed material was developed to support laser velocimeter investigations of the NASA Low-Speed Centrifugal Compressor flow field. The seeding system and the major concerns that were addressed during its development are described. Of primary importance were that the seed material be dispersed as single particles and that the liquid carrier used be completely evaporated before entering the compressor.

Validation Data for Mechanical System Algorithms Used in Building Energy Analysis Programs.

DTIC Science & Technology

1982-02-01

15 Zone Design 15 Built-Up Air Handler 15 Ventilation Requirements 16 The DES 16 Duct Design 17 Air -Delivery System 17 VAV Operation 17 Constant Volume...observed to operate well at reduced air flows, even at low flow in the so- called surge region. Recommendations 1. The HVAC system and component...With Inlet Guide Vanes Operating Within a Built-Up Air Handler 31 Test 2 -- Boiler Operation, Capacity, Efficiency, and Stand-By Losses 32 Test 3

A new Doppler-echo method to quantify regurgitant volume.

PubMed

Wang, S S; Rubenstein, J J; Goldman, M; Sidd, J J

1992-01-01

An in vitro technique using color flow imaging and continuous wave Doppler was developed to measure the initial regurgitant flow jet diameter and velocity integral to yield the parameters for a volume calculation. Jets were produced by volume-controlled injection through tubes of various diameters (1.3, 1.9, 2.8, and 3.5 mm) to deliver volumes from 1 to 7 ml over 100 to 300 msec at pressures from 40 to 200 mm Hg. One hundred forty-five samples were obtained. Flow jet diameter consistently overestimated tube diameter by 2 mm when injected volume was 1.5 to 7 ml and by 1.5 mm when injected volume was less than 1.5 ml. This offset was stable with various transducers (2.5, 3.5, 5.0 MHz) at normal gain setting (just under noise). Therefore, corrected flow jet diameter (FJD) = FJD - 2 mm, and Doppler volume = corrected flow jet area x velocity integral. A range of injectates from 1.1 to 7 ml generated Doppler volume of 1.0 to 8.2 ml. The relation between Doppler volume (DV) and injected volume (IV) was DV = 1.079 IV - 0.22, r2 = 0.945, p less than 0.01. This relation was not altered by tube diameter. Thus a method combining color flow imaging and continuous wave Doppler provides a reliable and accurate measure of in vitro flow volume.

A PROPOSED CHEMICAL INFORMATION AND DATA SYSTEM. VOLUME I.

DTIC Science & Technology

CHEMICAL COMPOUNDS, *DATA PROCESSING, *INFORMATION RETRIEVAL, * CHEMICAL ANALYSIS, INPUT OUTPUT DEVICES, COMPUTER PROGRAMMING, CLASSIFICATION...CONFIGURATIONS, DATA STORAGE SYSTEMS, ATOMS, MOLECULES, PERFORMANCE( ENGINEERING ), MAINTENANCE, SUBJECT INDEXING, MAGNETIC TAPE, AUTOMATIC, MILITARY REQUIREMENTS, TYPEWRITERS, OPTICS, TOPOLOGY, STATISTICAL ANALYSIS, FLOW CHARTING.

Factors influencing the measurement of closing volume.

PubMed

Make, B; Lapp, N L

1975-06-01

The various factors influencing closing volume were studied by performing the single-breath N2 test on 9 healthy nonsmokers. Time of day, day of the week, and preceding volume history had no effect on either closing volume or alveolar plateau. Slow inspiratory flow resulted in larger ratio of closing volume to vital capacity, ratio of closing capacity to total lung capacity, and change in N2 concentration than fast inspiratory flow. Voluntary regulation of the expiratory flow resulted in smaller ratios of closing volume to vital capacity and closing capacity to total lung capacity than when flow was regulated by a resistance. Prolonged breath holding of the inspired O2 led to larger ratio of closing volume to vital capacity and ratio of closing capacity to total lung capacity. To obtain uniform, comparable closing volumes, it is suggested that the subject inspire slowly, control expiratory flow (preferably voluntarily), and not pause between inspiration and expiration.

Electrical Capacitance Volume Tomography for the Packed Bed Reactor ISS Flight Experiment

NASA Technical Reports Server (NTRS)

Marashdeh, Qussai; Motil, Brian; Wang, Aining; Liang-Shih, Fan

2013-01-01

Fixed packed bed reactors are compact, require minimum power and maintenance to operate, and are highly reliable. These features make this technology a highly desirable unit operation for long duration life support systems in space. NASA is developing an ISS experiment to address this technology with particular focus on water reclamation and air revitalization. Earlier research and development efforts funded by NASA have resulted in two hydrodynamic models which require validation with appropriate instrumentation in an extended microgravity environment. To validate these models, the instantaneous distribution of the gas and liquid phases must be measured.Electrical Capacitance Volume Tomography (ECVT) is a non-invasive imaging technology recently developed for multi-phase flow applications. It is based on distributing flexible capacitance plates on the peripheral of a flow column and collecting real-time measurements of inter-electrode capacitances. Capacitance measurements here are directly related to dielectric constant distribution, a physical property that is also related to material distribution in the imaging domain. Reconstruction algorithms are employed to map volume images of dielectric distribution in the imaging domain, which is in turn related to phase distribution. ECVT is suitable for imaging interacting materials of different dielectric constants, typical in multi-phase flow systems. ECVT is being used extensively for measuring flow variables in various gas-liquid and gas-solid flow systems. Recent application of ECVT include flows in risers and exit regions of circulating fluidized beds, gas-liquid and gas-solid bubble columns, trickle beds, and slurry bubble columns. ECVT is also used to validate flow models and CFD simulations. The technology is uniquely qualified for imaging phase concentrations in packed bed reactors for the ISS flight experiments as it exhibits favorable features of compact size, low profile sensors, high imaging speed, and flexibility to fit around columns of various shapes and sizes. ECVT is also safer than other commonly used imaging modalities as it operates in the range of low frequencies (1 MHz) and does not radiate radioactive energy. In this effort, ECVT is being used to image flow parameters in a packed bed reactor for an ISS flight experiment.

A Comparison of Flow-Through Versus Non-Flow-Through Proton Exchange Membrane Fuel Cell Systems for NASA's Exploration Missions

NASA Technical Reports Server (NTRS)

Hoberecht, Mark A.

2010-01-01

As part of the Exploration Technology Development Program (ETDP) under the auspices of the Exploration Systems Mission Directorate (ESMD), NASA is developing both primary fuel cell power systems and regenerative fuel cell (RFC) energy storage systems within the fuel cell portion of the Energy Storage Project. This effort is being led by the NASA Glenn Research Center (GRC) in partnership with the NASA Johnson Space Center (JSC), Jet Propulsion Laboratory (JPL), NASA Kennedy Space Center (KSC), and industrial partners. The development goals are to improve fuel cell and electrolysis stack electrical performance, reduce system mass, volume, and parasitic power requirements, and increase system life and reliability. A major focus of this effort has been the parallel development of both flow-through and non-flow-through proton exchange membrane (PEM) primary fuel cell power systems. The plan has been, at the appropriate time, to select a single primary fuel cell technology for eventual flight hardware development. Ideally, that appropriate time would occur after both technologies have achieved a technology readiness level (TRL) of six, which represents an engineering model fidelity PEM fuel cell system being successfully tested in a relevant environment. Budget constraints in fiscal year 2009 and beyond have prevented NASA from continuing to pursue the parallel development of both primary fuel cell options. Because very limited data exists for either system, a toplevel, qualitative assessment based on engineering judgement was performed expeditiously to provide guidance for a selection. At that time, the non-flow-through technology was selected for continued development because of potentially major advantages in terms of weight, volume, parasitic power, reliability, and life. This author believes that the advantages are significant enough, and the potential benefits great enough, to offset the higher state of technology readiness of flow-through technology. This paper summarizes the technical considerations which helped form the engineering judgement that led to the final decision.

Method and apparatus for controlling cross contamination of microfluid channels

DOEpatents

Hasselbrink, Jr., Ernest F.; Rehm, Jason E [Alameda, CA; Paul, Phillip H [Livermore, CA; Arnold, Don W [Livermore, CA

2006-02-07

A method for controlling fluid flow at junctions in microchannel systems. Control of fluid flow is accomplished generally by providing increased resistance to electric-field and pressure-driven flow in the form of regions of reduced effective cross-sectional area within the microchannels and proximate a channel junction. By controlling these flows in the region of a microchannel junction it is possible to eliminate sample dispersion and cross contamination and inject well-defined volumes of fluid from one channel to another.

Material point method modeling in oil and gas reservoirs

DOEpatents

Vanderheyden, William Brian; Zhang, Duan

2016-06-28

A computer system and method of simulating the behavior of an oil and gas reservoir including changes in the margins of frangible solids. A system of equations including state equations such as momentum, and conservation laws such as mass conservation and volume fraction continuity, are defined and discretized for at least two phases in a modeled volume, one of which corresponds to frangible material. A material point model technique for numerically solving the system of discretized equations, to derive fluid flow at each of a plurality of mesh nodes in the modeled volume, and the velocity of at each of a plurality of particles representing the frangible material in the modeled volume. A time-splitting technique improves the computational efficiency of the simulation while maintaining accuracy on the deformation scale. The method can be applied to derive accurate upscaled model equations for larger volume scale simulations.

Acoustic modes in fluid networks

NASA Technical Reports Server (NTRS)

Michalopoulos, C. D.; Clark, Robert W., Jr.; Doiron, Harold H.

1992-01-01

Pressure and flow rate eigenvalue problems for one-dimensional flow of a fluid in a network of pipes are derived from the familiar transmission line equations. These equations are linearized by assuming small velocity and pressure oscillations about mean flow conditions. It is shown that the flow rate eigenvalues are the same as the pressure eigenvalues and the relationship between line pressure modes and flow rate modes is established. A volume at the end of each branch is employed which allows any combination of boundary conditions, from open to closed, to be used. The Jacobi iterative method is used to compute undamped natural frequencies and associated pressure/flow modes. Several numerical examples are presented which include acoustic modes for the Helium Supply System of the Space Shuttle Orbiter Main Propulsion System. It should be noted that the method presented herein can be applied to any one-dimensional acoustic system involving an arbitrary number of branches.

A mathematical model to optimize the drain phase in gravity-based peritoneal dialysis systems.

PubMed

Akonur, Alp; Lo, Ying-Cheng; Cizman, Borut

2010-01-01

Use of patient-specific drain-phase parameters has previously been suggested to improve peritoneal dialysis (PD) adequacy. Improving management of the drain period may also help to minimize intraperitoneal volume (IPV). A typical gravity-based drain profile consists of a relatively constant initial fast-flow period, followed by a transition period and a decaying slow-flow period. That profile was modeled using the equation VD(t) = (V(D0) - Q(MAX) x t) xphi + (V(D0) x e(-alphat)) x (1 - phi), where V(D)(t) is the time-dependent dialysate volume; V(D0), the dialysate volume at the start of the drain; Q(MAX), the maximum drain flow rate; alpha, the exponential drain constant; and phi, the unit step function with respect to the flow transition. We simulated the effects of the assumed patient-specific maximum drain flow (Q(MAX)) and transition volume (psi), and the peritoneal volume percentage when transition occurs,for fixed device-specific drain parameters. Average patient transport parameters were assumed during 5-exchange therapy with 10 L of PD solution. Changes in therapy performance strongly depended on the drain parameters. Comparing 400 mL/85% with 200 mL/65% (Q(MAX/psi), drain time (7.5 min vs. 13.5 min) and IPV (2769 mL vs. 2355 mL) increased when the initial drain flow was low and the transition quick. Ultrafiltration and solute clearances remained relatively similar. Such differences were augmented up to a drain time of 22 minutes and an IPV of more than 3 L when Q(MAX) was 100 mL/min. The ability to model individual drain conditions together with water and solute transport may help to prevent patient discomfort with gravity-based PD. However, it is essential to note that practical difficulties such as displaced catheters and obstructed flow paths cause variability in drain characteristics even for the same patient, limiting the clinical applicability of this model.

Summer Research Program (1992). Summer Faculty Research Program (SFRP) Reports. Volume 2. Armstrong Laboratory

DTIC Science & Technology

1992-12-01

desirable. In this study, the proposed model consists of a thick-walled, highly deformable elastic tube in which the blood flow is described by linearized ...presented a mechanical model consisting of linearized Navier-Stokes and finite elasticity equations to predict blood pooling under acceleration stress... linear multielement model of the cardiovascular system which can calculate blood pressures and flows at any point in the cardio- vascular system. It

A High Performance Pulsatile Pump for Aortic Flow Experiments in 3-Dimensional Models.

PubMed

Chaudhury, Rafeed A; Atlasman, Victor; Pathangey, Girish; Pracht, Nicholas; Adrian, Ronald J; Frakes, David H

2016-06-01

Aortic pathologies such as coarctation, dissection, and aneurysm represent a particularly emergent class of cardiovascular diseases. Computational simulations of aortic flows are growing increasingly important as tools for gaining understanding of these pathologies, as well as for planning their surgical repair. In vitro experiments are required to validate the simulations against real world data, and the experiments require a pulsatile flow pump system that can provide physiologic flow conditions characteristic of the aorta. We designed a newly capable piston-based pulsatile flow pump system that can generate high volume flow rates (850 mL/s), replicate physiologic waveforms, and pump high viscosity fluids against large impedances. The system is also compatible with a broad range of fluid types, and is operable in magnetic resonance imaging environments. Performance of the system was validated using image processing-based analysis of piston motion as well as particle image velocimetry. The new system represents a more capable pumping solution for aortic flow experiments than other available designs, and can be manufactured at a relatively low cost.

The volume change during solidification

NASA Technical Reports Server (NTRS)

Rittich, M.

1985-01-01

The liquid-solid phase transformation of solidifying metallic melts is accompanied by a volume change Delta-Vm. This volume change produces a gravity-independent microscopic flow near the solidification front. In a ground-based laboratory, solidification processes are also affected by convection due to temperature and concentration gradients. A quantitative evaluation of the effects of these flows on the formation of structure requires reproducible values of Delta-Vm. Alloys with Delta-Vm = 0 would be best suited for such an evaluation, while alloys with a constant value for Delta-Vm are still usable. Another requirement is related to a solidus-liquidus interval which is as small as possible. One-phase alloys, which would be particularly well suited, could not be found. For these reasons, alloys which solidify in two phases, as for example eutectics, have been considered, taking into account the Al-Ge system. Attention is given to the volume change at the melting point, the measurement of this change, the volume change at solidification, and applications to terrestrial technology.

The enormous Chillos Valley Lahar: An ash-flow-generated debris flow from Cotopaxi Volcano, Ecuador

USGS Publications Warehouse

Mothes, P.A.; Hall, M.L.; Janda, R.J.

1998-01-01

The Chillos Valley Lahar (CVL), the largest Holocene debris flow in area and volume as yet recognized in the northern Andes, formed on Cotopaxi volcano's north and northeast slopes and descended river systems that took it 326 km north-northwest to the Pacific Ocean and 130+ km east into the Amazon basin. In the Chillos Valley, 40 km downstream from the volcano, depths of 80-160 m and valley cross sections up to 337000m2 are observed, implying peak flow discharges of 2.6-6.0 million m3/s. The overall volume of the CVL is estimated to be ???3.8 km3. The CVL was generated approximately 4500 years BP by a rhyolitic ash flow that followed a small sector collapse on the north and northeast sides of Cotopaxi, which melted part of the volcano's icecap and transformed rapidly into the debris flow. The ash flow and resulting CVL have identical components, except for foreign fragments picked up along the flow path. Juvenile materials, including vitric ash, crystals, and pumice, comprise 80-90% of the lahar's deposit, whereas rhyolitic, dacitic, and andesitic lithics make up the remainder. The sand-size fraction and the 2- to 10-mm fraction together dominate the deposit, constituting ???63 and ???15 wt.% of the matrix, respectively, whereas the silt-size fraction averages less than ???10 wt.% and the clay-size fraction less than 0.5 wt.%. Along the 326-km runout, these particle-size fractions vary little, as does the sorting coefficient (average = 2.6). There is no tendency toward grading or improved sorting. Limited bulking is recognized. The CVL was an enormous non-cohesive debris flow, notable for its ash-flow origin and immense volume and peak discharge which gave it characteristics and a behavior akin to large cohesive mudflows. Significantly, then, ash-flow-generated debris flows can also achieve large volumes and cover great areas; thus, they can conceivably affect large populated regions far from their source. Especially dangerous, therefore, are snowclad volcanoes with recent silicic ash-flow histories such as those found in the Andes and Alaska.

Computerized Production Process Planning. Volume 2. Benefit Analysis.

DTIC Science & Technology

1976-11-01

advantage , in the long term, Systems 2 and 3 will return greater economic benefits . Plots of the cumulative present value of the cash flow by year are...is economically viable for large parts manufac- turers and does offer significant advantages over Systems I and 2 in terms of intangible benefits ...AD-RI51 996 COMPUTERIZED PRODUCTION PROCESS PLANNING VOLUME 2 i/1.. BENEFIT ANRLYSIS(U) IIT RESEARCH INST CHICRGO IL SH H HU ET AL. NOV 76 DAAHNi-76

New technology increases perioperative haemoglobin levels for paediatric cardiopulmonary bypass: what is the benefit?

PubMed

Thuys, Clarke; Horton, Stephen; Bennett, Martin; Augustin, Simon

2006-01-01

Increasing perioperative haemoglobin level by reducing priming volume and maintaining a safe cardiopulmonary bypass (CPB) system is the aim of every perfusionist. In this study, we have compared the two membrane oxygenators and pump systems used for paediatric bypass at the Royal Children's Hospital on a regular basis since 1988. We looked at all patients who had the Cobe VPCML (Cobe Laboratories, Denver, CO, USA) and Terumo RX-05 (Terumo Corporation, Tokyo, Japan) oxygenators used for flows from 800 mL/min up to the maximum rated flow for the respective oxygenator from January 2002 until March 2004. The VPCML refers to using only the 0.4-m2 section of the oxygenator. The pump systems used were the Stöckert CAPS (Stöckert Instrumente GmbH, Munich, Germany) and Jostra HL 30 (Jostra AB, Lund, Sweden). Changing from the VPCML to the RX-05 resulted in a 37% reduction in priming volume. The introduction of the Jostra HL 30 with a custom-designed mast system reduced the priming volume by another 15%. This change in priming volume allowed a significant increase, from 6 to 34%, in the percentage of patients who received bloodless primes, and for those patients who received blood primes, an increase in haemoglobin (Hb) on bypass from 8.2 to 9.6 g/dL, on average.

The Sponge Pump: The Role of Current Induced Flow in the Design of the Sponge Body Plan

PubMed Central

Leys, Sally P.; Yahel, Gitai; Reidenbach, Matthew A.; Tunnicliffe, Verena; Shavit, Uri; Reiswig, Henry M.

2011-01-01

Sponges are suspension feeders that use flagellated collar-cells (choanocytes) to actively filter a volume of water equivalent to many times their body volume each hour. Flow through sponges is thought to be enhanced by ambient current, which induces a pressure gradient across the sponge wall, but the underlying mechanism is still unknown. Studies of sponge filtration have estimated the energetic cost of pumping to be <1% of its total metabolism implying there is little adaptive value to reducing the cost of pumping by using “passive” flow induced by the ambient current. We quantified the pumping activity and respiration of the glass sponge Aphrocallistes vastus at a 150 m deep reef in situ and in a flow flume; we also modeled the glass sponge filtration system from measurements of the aquiferous system. Excurrent flow from the sponge osculum measured in situ and in the flume were positively correlated (r>0.75) with the ambient current velocity. During short bursts of high ambient current the sponges filtered two-thirds of the total volume of water they processed daily. Our model indicates that the head loss across the sponge collar filter is 10 times higher than previously estimated. The difference is due to the resistance created by a fine protein mesh that lines the collar, which demosponges also have, but was so far overlooked. Applying our model to the in situ measurements indicates that even modest pumping rates require an energetic expenditure of at least 28% of the total in situ respiration. We suggest that due to the high cost of pumping, current-induced flow is highly beneficial but may occur only in thin walled sponges living in high flow environments. Our results call for a new look at the mechanisms underlying current-induced flow and for reevaluation of the cost of biological pumping and its evolutionary role, especially in sponges. PMID:22180779

Method, system and computer program product for monitoring and optimizing fluid extraction from geologic strata

DOEpatents

Medizade, Masoud [San Luis Obispo, CA; Ridgely, John Robert [Los Osos, CA

2009-12-15

An arrangement which utilizes an inexpensive flap valve/flow transducer combination and a simple local supervisory control system to monitor and/or control the operation of a positive displacement pump used to extract petroleum from geologic strata. The local supervisory control system controls the operation of an electric motor which drives a reciprocating positive displacement pump so as to maximize the volume of petroleum extracted from the well per pump stroke while minimizing electricity usage and pump-off situations. By reducing the electrical demand and pump-off (i.e., "pounding" or "fluid pound") occurrences, operating and maintenance costs should be reduced sufficiently to allow petroleum recovery from marginally productive petroleum fields. The local supervisory control system includes one or more applications to at least collect flow signal data generated during operation of the positive displacement pump. No flow, low flow and flow duration are easily evaluated using the flap valve/flow transducer arrangement.

Does a pneumotach accurately characterize voice function?

NASA Astrophysics Data System (ADS)

Walters, Gage; Krane, Michael

2016-11-01

A study is presented which addresses how a pneumotach might adversely affect clinical measurements of voice function. A pneumotach is a device, typically a mask, worn over the mouth, in order to measure time-varying glottal volume flow. By measuring the time-varying difference in pressure across a known aerodynamic resistance element in the mask, the glottal volume flow waveform is estimated. Because it adds aerodynamic resistance to the vocal system, there is some concern that using a pneumotach may not accurately portray the behavior of the voice. To test this hypothesis, experiments were performed in a simplified airway model with the principal dimensions of an adult human upper airway. A compliant constriction, fabricated from silicone rubber, modeled the vocal folds. Variations of transglottal pressure, time-averaged volume flow, model vocal fold vibration amplitude, and radiated sound with subglottal pressure were performed, with and without the pneumotach in place, and differences noted. Acknowledge support of NIH Grant 2R01DC005642-10A1.

Ceramic microsystem incorporating a microreactor with immobilized biocatalyst for enzymatic spectrophotometric assays.

PubMed

Baeza, Mireia; López, Carmen; Alonso, Julián; López-Santín, Josep; Alvaro, Gregorio

2010-02-01

Low-temperature cofired ceramics (LTCC) technology is a versatile fabrication technique used to construct microflow systems. It permits the integration of several unitary operations (pretreatment, separation, (bio)chemical reaction, and detection stage) of an analytical process in a modular or monolithic way. Moreover, because of its compatibility with biological material, LTCC is adequate for analytical applications based on enzymatic reactions. Here we present the design, construction, and evaluation of a LTCC microfluidic system that integrates a microreactor (internal volume, 24.28 microL) with an immobilized beta-galactosidase from Escherichia coli (0.479 activity units) and an optical flow cell to measure the product of the enzymatic reaction. The enzyme was immobilized on a glyoxal-agarose support, maintaining its activity along the time of the study. As a proof of concept, the LTCC-beta-galactosidase system was tested by measuring the conversion of ortho-nitrophenyl beta-D-galactopyranoside, the substrate usually employed for activity determinations. Once packed in a monolithically integrated microcolumn, the miniaturized flow system was characterized, the operational conditions optimized (flow rate and injection volume), and its performance successfully evaluated by determining the beta-galactosidase substrate concentration at the millimolar level.

An annotation system for 3D fluid flow visualization

NASA Technical Reports Server (NTRS)

Loughlin, Maria M.; Hughes, John F.

1995-01-01

Annotation is a key activity of data analysis. However, current systems for data analysis focus almost exclusively on visualization. We propose a system which integrates annotations into a visualization system. Annotations are embedded in 3D data space, using the Post-it metaphor. This embedding allows contextual-based information storage and retrieval, and facilitates information sharing in collaborative environments. We provide a traditional database filter and a Magic Lens filter to create specialized views of the data. The system has been customized for fluid flow applications, with features which allow users to store parameters of visualization tools and sketch 3D volumes.

A novel coronary active perfusion system using a conventional intra-aortic balloon pump for off-pump coronary artery bypass grafting.

PubMed

Kiuchi, Ryuta; Tomita, Shigeyuki; Yamaguchi, Shojiro; Nishida, Yuji; Ohtake, Hiroshi; Nakamura, Hiroyuki; Watanabe, Go

2014-07-01

It is important for coronary active perfusion systems to avoid myocardial ischemia during off-pump coronary artery bypass grafting. We have developed a new concept for a perfusion system to pump blood based on changes in helium gas volume. This system uses a conventional intra-aortic balloon pump to activate the perfusion pump. Our study used basic and animal experiments to investigate the most suitable system for coronary perfusion using this new concept. A conventional intra-aortic balloon pump was used to supply power. A device for perfusion was developed with a balloon placed inside a stiff syringe barrel. The device was connected to the helium gas line of the intra-aortic balloon pump. Changes in flow with changes in augmentation level were noted when volumes outside and within the balloon were changed. Six pigs with occlusion of the left anterior descending artery were used for system validation, with monitoring to identify changes in hemodynamics and cardiac enzyme levels. In the basic experiment, an 80-mL outside volume and 3.0-mL inner volume resulted in the greatest percentage change in flow rate with respect to changes in augmentation. In the animal experiment, the new coronary active perfusion system prevented myocardial ischemia during coronary occlusion. We clarified the most suitable method for our new coronary active perfusion system. Using this system, safe anastomosis was consistently performed in animal experiments. Clinically, off-pump coronary artery bypass may potentially be performed more safely and easily using this new system. Copyright © 2014 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.

Streak Imaging Flow Cytometer for Rare Cell Analysis.

PubMed

Balsam, Joshua; Bruck, Hugh Alan; Ossandon, Miguel; Prickril, Ben; Rasooly, Avraham

2017-01-01

There is a need for simple and affordable techniques for cytology for clinical applications, especially for point-of-care (POC) medical diagnostics in resource-poor settings. However, this often requires adapting expensive and complex laboratory-based techniques that often require significant power and are too massive to transport easily. One such technique is flow cytometry, which has great potential for modification due to the simplicity of the principle of optical tracking of cells. However, it is limited in that regard due to the flow focusing technique used to isolate cells for optical detection. This technique inherently reduces the flow rate and is therefore unsuitable for rapid detection of rare cells which require large volume for analysis.To address these limitations, we developed a low-cost, mobile flow cytometer based on streak imaging. In our new configuration we utilize a simple webcam for optical detection over a large area associated with a wide-field flow cell. The new flow cell is capable of larger volume and higher throughput fluorescence detection of rare cells than the flow cells with hydrodynamic focusing used in conventional flow cytometry. The webcam is an inexpensive, commercially available system, and for fluorescence analysis we use a 1 W 450 nm blue laser to excite Syto-9 stained cells with emission at 535 nm. We were able to detect low concentrations of stained cells at high flow rates of 10 mL/min, which is suitable for rapidly analyzing larger specimen volumes to detect rare cells at appropriate concentration levels. The new rapid detection capabilities, combined with the simplicity and low cost of this device, suggest a potential for clinical POC flow cytometry in resource-poor settings associated with global health.

Respiratory mechanics and breathing pattern in the neonatal foal.

PubMed

Koterba, A M; Kosch, P C

1987-01-01

Breathing pattern, respiratory muscle activation pattern, lung volumes and volume-pressure characteristics of the respiratory system of normal, term, neonatal foals on Days 2 and 7 of age were determined to test the hypothesis that the foal actively maintains end-expiratory lung volume (EEV) greater than the relaxation volume of the respiratory system (Vrx) because of a highly compliant chest wall. Breathing pattern was measured in the awake, unsedated foal during quiet breathing in lateral and standing positions. The typical neonatal foal breathing pattern was characterized by a monophasic inspiratory and expiratory flow pattern. Both inspiration and expiration were active, with onset of Edi activity preceding onset of inspiratory flow, and phasic abdominal muscle activity detectable throughout most of expiration. No evidence was found to support the hypothesis that the normal, term neonatal foal actively maintains EEV greater than Vrx. In the neonatal foal, normalized lung volume and lung compliance values were similar to those reported for neonates of other species, while normalized chest wall compliance was considerably lower. We conclude that the chest wall of the term neonatal foal is sufficiently rigid to prevent a low Vrx. This characteristic probably prevents the foal from having to use a breathing strategy which maintains an EEV greater than Vrx.

Heat Transfer Characteristics of Fan Coil Unit (FCU) Under The Effect of Chilled Water Volume Flowrate

NASA Astrophysics Data System (ADS)

Wijaya Sunu, Putu; Anakottapary, Daud Simon; Mulawarman, A. A. N. B.; Cipta Santosa, I. D. M.; Putu Sastra Negara, I.

2018-01-01

In this paper, the volume flowrate of chilled water in the water chiller simulation apparatus was optimized using experimental studied. The experimental analysis was performed on the fan coil unit (FCU) of the system. The chilled water flows in tube side and the air as a hot fluid flows throughout the tube and fin of FCU. The thermal performance and analysis of the heat transfer is examined using various chilled water flowrate e.g. 11, 12, 13, 14, 15 lpm. The effect of the flowrate to the important parameter such as LMTD temperature, heat absorb used for investigate the heat transfer characteristics. The result showed that the heat transfer characteristics has been increased with the increased of chilled water volume flowrate.

The capability of radial basis function to forecast the volume fractions of the annular three-phase flow of gas-oil-water.

PubMed

Roshani, G H; Karami, A; Salehizadeh, A; Nazemi, E

2017-11-01

The problem of how to precisely measure the volume fractions of oil-gas-water mixtures in a pipeline remains as one of the main challenges in the petroleum industry. This paper reports the capability of Radial Basis Function (RBF) in forecasting the volume fractions in a gas-oil-water multiphase system. Indeed, in the present research, the volume fractions in the annular three-phase flow are measured based on a dual energy metering system including the 152 Eu and 137 Cs and one NaI detector, and then modeled by a RBF model. Since the summation of volume fractions are constant (equal to 100%), therefore it is enough for the RBF model to forecast only two volume fractions. In this investigation, three RBF models are employed. The first model is used to forecast the oil and water volume fractions. The next one is utilized to forecast the water and gas volume fractions, and the last one to forecast the gas and oil volume fractions. In the next stage, the numerical data obtained from MCNP-X code must be introduced to the RBF models. Then, the average errors of these three models are calculated and compared. The model which has the least error is picked up as the best predictive model. Based on the results, the best RBF model, forecasts the oil and water volume fractions with the mean relative error of less than 0.5%, which indicates that the RBF model introduced in this study ensures an effective enough mechanism to forecast the results. Copyright © 2017 Elsevier Ltd. All rights reserved.

Breathing simulator of workers for respirator performance test.

PubMed

Yuasa, Hisashi; Kumita, Mikio; Honda, Takeshi; Kimura, Kazushi; Nozaki, Kosuke; Emi, Hitoshi; Otani, Yoshio

2015-01-01

Breathing machines are widely used to evaluate respirator performance but they are capable of generating only limited air flow patterns, such as, sine, triangular and square waves. In order to evaluate the respirator performance in practical use, it is desirable to test the respirator using the actual breathing patterns of wearers. However, it has been a difficult task for a breathing machine to generate such complicated flow patterns, since the human respiratory volume changes depending on the human activities and workload. In this study, we have developed an electromechanical breathing simulator and a respiration sampling device to record and reproduce worker's respiration. It is capable of generating various flow patterns by inputting breathing pattern signals recorded by a computer, as well as the fixed air flow patterns. The device is equipped with a self-control program to compensate the difference in inhalation and exhalation volume and the measurement errors on the breathing flow rate. The system was successfully applied to record the breathing patterns of workers engaging in welding and reproduced the breathing patterns.

Comprehensive integrated spirometry using raised volume passive and forced expirations and multiple-breath nitrogen washout in infants.

PubMed

Morris, Mohy G

2010-02-28

With the rapid somatic growth and development in infants, simultaneous accurate measurements of lung volume and airway function are essential. Raised volume rapid thoracoabdominal compression (RTC) is widely used to generate forced expiration from an airway opening pressure of 30 cmH(2)O (V(30)). The (dynamic) functional residual capacity (FRC(dyn)) remains the lung volume most routinely measured. The aim of this study was to develop comprehensive integrated spirometry that included all subdivisions of lung volume at V(30) or total lung capacity (TLC(30)). Measurements were performed on 17 healthy infants aged 8.6-119.7 weeks. A commercial system for multiple-breath nitrogen washout (MBNW) to measure lung volumes and a custom made system to perform RTC were used in unison. A refined automated raised volume RTC and the following two novel single maneuvers with dual volume measurements were performed from V(30) during a brief post-hyperventilation apneic pause: (1) the passive expiratory flow was integrated to produce the inspiratory capacity (IC) and the static (passive) FRC (FRC(st)) was estimated by initiating MBNW after end-passive expiration; (2) RTC was initiated late during passive expiration, flow was integrated to produce the slow vital capacity ((j)SVC) and the residual volume (RV) was measured by initiating MBNW after end-expiration while the jacket (j) was inflated. Intrasubject FRC(dyn) and FRC(st) measurements overlapped (p=0.6420) but neither did with the RV (p<0.0001). Means (95% confidence interval) of FRC(dyn), IC, FRC(st), (j)SVC, RV, forced vital capacity and tidal volume were 21.2 (19.7-22.7), 36.7 (33.0-40.4), 21.2 (19.6-22.8), 40.7 (37.2-44.2), 18.1 (16.6-19.7), 40.7 (37.1-44.2) and 10.2 (9.6-10.7)ml/kg, respectively. Static lung volumes and capacities at V(30) and variables from the best forced expiratory flow-volume curve were dependent on age, body length and weight. In conclusion, we developed a comprehensive physiologically integrated approach for in-depth investigation of lung function at V(30) in infants. Copyright 2009 Elsevier B.V. All rights reserved.

40 CFR 51.363 - Quality assurance.

Code of Federal Regulations, 2011 CFR

2011-07-01

... test, the evaporative system tests, and emission control component checks (as applicable); (vi...) A check of the Constant Volume Sampler flow calibration; (5) A check for the optimization of the... selection, and power absorption; (9) A check of the system's ability to accurately detect background...

Analysis of potential debris flow source areas on Mount Shasta, California, by using airborne and satellite remote sensing data

USGS Publications Warehouse

Crowley, J.K.; Hubbard, B.E.; Mars, J.C.

2003-01-01

Remote sensing data from NASA's Airborne Visible/Infrared Imaging Spectrometer (AVIRIS) and the first spaceborne imaging spectrometer, Hyperion, show hydrothermally altered rocks mainly composed of natroalunite, kaolinite, cristobalite, and gypsum on both the Mount Shasta and Shastina cones. Field observations indicate that much of the visible altered rock consists of talus material derived from fractured rock zones within and adjacent to dacitic domes and nearby lava flows. Digital elevation data were utilized to distinguish steeply sloping altered bedrock from more gently sloping talus materials. Volume modeling based on the imagery and digital elevation data indicate that Mount Shasta drainage systems contain moderate volumes of altered rock, a result that is consistent with Mount Shasta's Holocene record of mostly small to moderate debris flows. Similar modeling for selected areas at Mount Rainier and Mount Adams, Washington, indicates larger altered rock volumes consistent with the occurrence of much larger Holocene debris flows at those volcanoes. The availability of digital elevation and spectral data from spaceborne sensors, such as Hyperion and the Advanced Spaceborne Thermal Emission and Reflectance Radiometer (ASTER), greatly expands opportunities for studying potential debris flow source characteristics at stratovolcanoes around the world. ?? 2003 Elsevier Inc. All rights reserved.

MRI, volumetry, 1H spectroscopy, and cerebropetal blood flowmetry in childhood idiopathic anatomic megalencephaly.

PubMed

Koudijs, Suzanne M; van der Grond, Jeroen; Hoogendoorn, Mechteld L C; Hulshoff Pol, Hilleke E; Schnack, Hugo G; Witkamp, Theo D; Gooskens, Rob H J M; van Nieuwenhuizen, Onno; Braun, Kees P J

2006-08-01

To evaluate cerebral abnormalities in childhood idiopathic anatomic megalencephaly (MC) by means of different magnetic resonance (MR) modalities. MRI, volumetry, spectroscopy, and cerebropetal blood flowmetry were performed in six children with idiopathic anatomic MC, and seven volunteers. MRI revealed an increased ventricular system in five of six patients. A thalamic hamartoma was found in one patient and a Chiari I malformation was found in two. Volumetric analysis showed a disproportional increase of ventricular volume but normal subarachnoid cerebrospinal fluid (CSF) volume. Supratentorial volume was disproportionally increased compared to cerebellar volume. Intracranial volume correlated significantly with skull circumference. MR spectroscopy (MRS) N-acetyl aspartate/choline (NAA/Cho) peak ratios in WM were significantly higher in patients than in controls. Choline/creatine (Cho/Cr) peak ratios in WM were significantly lower in patients. Cortical gray matter (GM) MRS ratios were unaltered. Cerebropetal flow was increased in MC, possibly related to increased brain volume. This study reveals associated developmental anomalies for idiopathic anatomic MC. A relative ventriculomegaly was found, which should not be misinterpreted as true hydrocephalus. In contrast to metabolic MC, MRS showed no severe disturbances. Total intracranial volume is correlated to skull circumference and cerebropetal blood flow.

Measuring the Osmotic Water Permeability of the Plant Protoplast Plasma Membrane: Implication of the Nonosmotic Volume

PubMed Central

2010-01-01

Starting from the original theoretical descriptions of osmotically induced water volume flow in membrane systems, a convenient procedure to determine the osmotic water permeability coefficient (Pos) and the relative nonosmotic volume (β) of individual protoplasts is presented. Measurements performed on protoplasts prepared from pollen grains and pollen tubes of Lilium longiflorum cv. Thunb. and from mesophyll cells of Nicotiana tabacum L. and Arabidopsis thaliana revealed low values for the osmotic water permeability coefficient in the range 5–20 μm · s−1 with significant differences in Pos, depending on whether β is considered or not. The value of β was determined using two different methods: by interpolation from Boyle-van’t Hoff plots or by fitting a solution of the theoretical equation for water volume flow to the whole volume transients measured during osmotic swelling. The values determined with the second method were less affected by the heterogeneity of the protoplast samples and were around 30% of the respective isoosmotic protoplast volume. It is therefore important to consider nonosmotic volume in the calculation of Pos as plant protoplasts behave as nonideal osmometers. PMID:17568979

Capacitance probe for fluid flow and volume measurements

NASA Technical Reports Server (NTRS)

Arndt, G. Dickey (Inventor); Nguyen, Thanh X. (Inventor); Carl, James R. (Inventor)

1995-01-01

Method and apparatus for making measurements on fluids are disclosed, including the use of a capacitive probe for measuring the flow volume of a material within a flow stream. The capacitance probe has at least two elongate electrodes and, in a specific embodiment of the invention, has three parallel elongate electrodes with the center electrode being an extension of the center conductor of a co-axial cable. A conductance probe is also provided to provide more accurate flow volume data in response to conductivity of the material within the flow stream. A preferred embodiment of the present invention provides for a gas flow stream through a microgravity environment that allows for monitoring a flow volume of a fluid sample, such as a urine sample, that is entrained within the gas flow stream.

Capacitance Probe for Fluid Flow and Volume Measurements

NASA Technical Reports Server (NTRS)

Arndt, G. Dickey (Inventor); Nguyen, Thanh X. (Inventor); Carl, James R. (Inventor)

1997-01-01

Method and apparatus for making measurements on fluids are disclosed, including the use of a capacitive probe for measuring the flow volume of a material within a flow stream. The capacitance probe has at least two elongate electrodes and, in a specific embodiment of the invention, has three parallel elongate electrodes with the center electrode being an extension of the center conductor of a co-axial cable. A conductance probe is also provided to provide more accurate flow volume data in response to conductivity of the material within the flow stream. A preferred embodiment of the present invention provides for a gas flow stream through a micro-gravity environment that allows for monitoring a flow volume of a fluid sample, such as a urine sample, that is entrained within the gas flow stream.

Large-Flow-Area Flow-Selective Liquid/Gas Separator

NASA Technical Reports Server (NTRS)

Vasquez, Arturo; Bradley, Karla F.

2010-01-01

This liquid/gas separator provides the basis for a first stage of a fuel cell product water/oxygen gas phase separator. It can separate liquid and gas in bulk in multiple gravity environments. The system separates fuel cell product water entrained with circulating oxygen gas from the outlet of a fuel cell stack before allowing the gas to return to the fuel cell stack inlet. Additional makeup oxygen gas is added either before or after the separator to account for the gas consumed in the fuel cell power plant. A large volume is provided upstream of porous material in the separator to allow for the collection of water that does not exit the separator with the outgoing oxygen gas. The water then can be removed as it continues to collect, so that the accumulation of water does not impede the separating action of the device. The system is designed with a series of tubes of the porous material configured into a shell-and-tube heat exchanger configuration. The two-phase fluid stream to be separated enters the shell-side portion of the device. Gas flows to the center passages of the tubes through the porous material and is then routed to a common volume at the end of the tubes by simple pressure difference from a pumping device. Gas flows through the porous material of the tubes with greater ease as a function of the ratio of the dynamic viscosity of the water and gas. By careful selection of the dimensions of the tubes (wall thickness, porosity, diameter, length of the tubes, number of the tubes, and tube-to-tube spacing in the shell volume) a suitable design can be made to match the magnitude of water and gas flow, developed pressures from the oxygen reactant pumping device, and required residual water inventory for the shellside volume.

( sup 99m Tc)diphosphonate uptake and hemodynamics in arthritis of the immature dog knee

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hansen, E.S.; Soballe, K.; Henriksen, T.B.

1991-03-01

The relationship between (99mTc)diphosphonate uptake and bone hemodynamics was studied in canine carrageenan-induced juvenile chronic arthritis. Blood flow was determined with microspheres, plasma and red cell volumes were measured by labeled fibrinogen and red cells, and the microvascular volume and mean transit time of blood were calculated. Normal femoral epiphyses had lower central and higher subchondral blood flow and diphosphonate uptake values. Epiphyseal vascular volume was uniform, resulting in a greater transit time of blood centrally. In arthritis, blood flow and diphosphonate uptake were increased subchondrally and unaffected centrally, while epiphyseal vascular volume was increased throughout, leading to prolonged transitmore » time centrally. The normal metaphyses had low blood flow and diphosphonate uptake values in cancellous bone and very high values in growth plates, but a large vascular volume throughout. The mean transit time therefore was low in growth plates and high in adjacent cancellous bone. Arthritis caused decreased blood flow and diphosphonate uptake in growth plates but increased vascular volume and transit time of blood. Diphosphonate uptake correlated positively with blood flow and plasma volume and negatively with red cell volume in a nonlinear fashion. Thus, changes in diphosphonate uptake and microvascular hemodynamics occur in both epiphyseal and metaphyseal bone in chronic synovitis of the immature knee. The (99mTc)diphosphonate bone scan seems to reflect blood flow, plasma volume, and red cell volume of bone.« less

Simulating on water storage and pump capacity of "Kencing" river polder system in Kudus regency, Central Java, Indonesia

NASA Astrophysics Data System (ADS)

Wahyudi, Slamet Imam; Adi, Henny Pratiwi; Santoso, Esti; Heikoop, Rick

2017-03-01

Settlement in the Jati District, Kudus Regency, Central Java Province, Indonesia, is growing rapidly. Previous paddy fields area turns into new residential, industrial and office buildings. The rain water collected in small Kencing river that flows into big Wulan River. But the current condition, during high rain intensity Wulan river water elevation higher than the Kencing river, so that water can not flow gravity and the area inundated. To reduce the flooding, required polder drainage system by providing a long channel as water storage and pumping water into Wulan river. How to get optimal value of water storage volume, drainage system channels and the pump capacity? The result used to be efficient in the operation and maintenance of the polder system. The purpose of this study is to develop some scenarios water storage volume, water gate operation and to get the optimal value of operational pumps removing water from the Kencing River to Wulan River. Research Method is conducted by some steps. The first step, it is done field orientation in detail, then collecting secondary data including maps and rainfall data. The map is processed into Watershed or catchment area, while the rainfall data is processed into runoff discharge. Furthermore, the team collects primary data by measuring topography to determine the surface and volume of water storage. The analysis conducted to determine of flood discharge, water channel hydraulics, water storage volume and pump capacity corresponding. Based on the simulating of long water storage volume and pump capacity with some scenario trying, it can be determined optimum values. The results used to be guideline in to construction proses, operation and maintenance of the drainage polder system.

Understanding leachate flow in municipal solid waste landfills by combining time-lapse ERT and subsurface flow modelling - Part I: Analysis of infiltration shape on two different waste deposit cells.

PubMed

Audebert, M; Clément, R; Moreau, S; Duquennoi, C; Loisel, S; Touze-Foltz, N

2016-09-01

Landfill bioreactors are based on an acceleration of in-situ waste biodegradation by performing leachate recirculation. To quantify the water content and to evaluate the leachate injection system, in-situ methods are required to obtain spatially distributed information, usually electrical resistivity tomography (ERT). In a previous study, the MICS (multiple inversions and clustering strategy) methodology was proposed to improve the hydrodynamic interpretation of ERT results by a precise delimitation of the infiltration area. In this study, MICS was applied on two ERT time-lapse data sets recorded on different waste deposit cells in order to compare the hydrodynamic behaviour of leachate flow between the two cells. This comparison is based on an analysis of: (i) the volume of wetted waste assessed by MICS and the wetting rate, (ii) the infiltration shapes and (iii) the pore volume used by the leachate flow. This paper shows that leachate hydrodynamic behaviour is comparable from one waste deposit cell to another with: (i) a high leachate infiltration speed at the beginning of the infiltration, which decreases with time, (ii) a horizontal anisotropy of the leachate infiltration shape and (iii) a very small fraction of the pore volume used by the leachate flow. This hydrodynamic information derived from MICS results can be useful for subsurface flow modelling used to predict leachate flow at the landfill scale. Copyright © 2016 Elsevier Ltd. All rights reserved.

The 1980-81 AFOSR (Air Force Office of Scientific Research)-HTTM (Heat Transfer and Turbulence Mechanics)-Stanford Conference on Complex Turbulent Flows: Comparison of Computation and Experiment. Volume 3. Comparison of Computation with Experiment, and Computors’ Summary Report.

DTIC Science & Technology

1981-09-01

organized the paperwork system , including finances, travel, k, , f iling, and programs in a highly independent and responsible fashion. Thanks are also due...three-dimensional transformation procedure for arbitrary non-orthogonal coordinate systems , for the purpose of the three-dimensional turbulent...transformation procedure for arbitrary non-orthogonal coordinate systems so as to acquire the generality in the application for elliptic flows (for the square

Multiphase fluid characterization system

DOEpatents

Sinha, Dipen N.

2014-09-02

A measurement system and method for permitting multiple independent measurements of several physical parameters of multiphase fluids flowing through pipes are described. Multiple acoustic transducers are placed in acoustic communication with or attached to the outside surface of a section of existing spool (metal pipe), typically less than 3 feet in length, for noninvasive measurements. Sound speed, sound attenuation, fluid density, fluid flow, container wall resonance characteristics, and Doppler measurements for gas volume fraction may be measured simultaneously by the system. Temperature measurements are made using a temperature sensor for oil-cut correction.

Variable volume combustor with aerodynamic fuel flanges for nozzle mounting

DOE Office of Scientific and Technical Information (OSTI.GOV)

McConnaughhay, Johnie Franklin; Keener, Christopher Paul; Johnson, Thomas Edward

2016-09-20

The present application provides a combustor for use with a gas turbine engine. The combustor may include a number of micro-mixer fuel nozzles and a fuel injection system for providing a flow of fuel to the micro-mixer fuel nozzles. The fuel injection system may include a number of support struts supporting the fuel nozzles and for providing the flow of fuel therethrough. The fuel injection system also may include a number of aerodynamic fuel flanges connecting the micro-mixer fuel nozzles and the support struts.

Hydrodynamic comparison of the Penumbra system and commonly available syringes in forced-suction thrombectomy.

PubMed

Simon, Scott Douglas; Grey, Casey Paul

2014-04-01

The Penumbra system uses a coaxial separator and continuous extracorporeal suction to remove a clot from a cerebral artery. Forced-suction thrombectomy (FST) involves aspirating clots through the same reperfusion catheter using only a syringe, decreasing the procedure time and supplies needed. To evaluate multiple combinations of catheters and syringes to determine the optimal pairing for use in FST. Tests were performed using both the Penumbra system and syringes to aspirate water through Penumbra 0.041 inch (041), 4Max, 0.054 inch (054) and 5Max reperfusion catheters and a shuttle sheath. Dynamic pressure and flow at the catheter tip were calculated from the fill times for each system. Static pressure and force for each aspiration source were determined with a vacuum gauge. All syringes provided significantly higher dynamic pressure at the catheter tip than the Penumbra system (p<0.001). Increasing syringe volume significantly increased static pressure (p<0.001). Both flow and aspiration force significantly increased with catheter size (p<0.001). Cases are presented to demonstrate the clinical value of the laboratory principles. Maximizing static and dynamic pressure when performing FST is achieved by aspirating with a syringe possessing both the largest volume and the largest inlet diameter available. Maximizing aspiration force and flow rate is achieved by using the largest catheter possible.

Potentiometric chip-based multipumping flow system for the simultaneous determination of fluoride, chloride, pH, and redox potential in water samples.

PubMed

Chango, Gabriela; Palacio, Edwin; Cerdà, Víctor

2018-08-15

A simple potentiometric chip-based multipumping flow system (MPFS) has been developed for the simultaneous determination of fluoride, chloride, pH, and redox potential in water samples. The proposed system was developed by using a poly(methyl methacrylate) chip microfluidic-conductor using the advantages of flow techniques with potentiometric detection. For this purpose, an automatic system has been designed and built by optimizing the variables involved in the process, such as: pH, ionic strength, stirring and sample volume. This system was applied successfully to water samples getting a versatile system with an analysis frequency of 12 samples per hour. Good correlation between chloride and fluoride concentration measured with ISE and ionic chromatography technique suggests satisfactory reliability of the system. Copyright © 2018 Elsevier B.V. All rights reserved.

Flow and axial dispersion in a sinusoidal-walled tube: Effects of inertial and unsteady flows

DOE Office of Scientific and Technical Information (OSTI.GOV)

Richmond, Marshall C.; Perkins, William A.; Scheibe, Timothy D.

2013-12-01

Dispersion in porous media flows has been the subject of much experimental, theoretical and numerical study. Here we consider a wavy-walled tube (a three-dimensional tube with sinusoidally-varying diameter) as a simplified conceptualization of flow in porous media, where constrictions represent pore throats and expansions pore bodies. A theoretical model for effective (macroscopic) longitudinal dispersion in this system has been developed by volume averaging the microscale velocity field. Direct numerical simulation using computational fluid dynamics (CFD) methods was used to compute velocity fields by solving the Navier-Stokes equations, and also to numerically solve the volume averaging closure problem, for a rangemore » of Reynolds numbers (Re) spanning the low-Re to inertial flow regimes, including one simulation at Re = 449 for which unsteady flow was observed. Dispersion values were computed using both the volume averaging solution and a random walk particle tracking method, and results of the two methods were shown to be consistent. Our results are compared to experimental measurements of dispersion in porous media and to previous theoretical results for the low-Re, Stokes flow regime. In the steady inertial regime we observe an power-law increase in effective longitudinal dispersion (DL) with Re, consistent with previous results. This rapid rate of increase is caused by trapping of solute in expansions due to flow separation (eddies). For the unsteady case (Re = 449), the rate of increase of DL with Re was smaller than that observed at lower Re. Velocity fluctuations in this regime lead to increased rates of solute mass transfer between the core flow and separated flow regions, thus diminishing the amount of tailing caused by solute trapping in eddies and thereby reducing longitudinal dispersion.« less

Surveillance of hemodialysis vascular access with ultrasound vector flow imaging

NASA Astrophysics Data System (ADS)

Brandt, Andreas H.; Olesen, Jacob B.; Hansen, Kristoffer L.; Rix, Marianne; Jensen, Jørgen A.; Nielsen, Michael B.

2015-03-01

The aim of this study was prospectively to monitor the volume flow in patients with arteriovenous fistula (AVF) with the angle independent ultrasound technique Vector Flow Imaging (VFI). Volume flow values were compared with Ultrasound dilution technique (UDT). Hemodialysis patients need a well-functioning vascular access with as few complications as possible and preferred vascular access is an AVF. Dysfunction due to stenosis is a common complication, and regular monitoring of volume flow is recommended to preserve AVF patency. UDT is considered the gold standard for volume flow surveillance, but VFI has proven to be more precise, when performing single repeated instantaneous measurements. Three patients with AVF were monitored with UDT and VFI monthly for five months. A commercial ultrasound scanner with a 9 MHz linear array transducer with integrated VFI was used to obtain data. UDT values were obtained with Transonic HD03 Flow-QC Hemodialysis Monitor. Three independent measurements at each scan session were obtained with UDT and VFI each month. Average deviation of volume flow between UDT and VFI was 25.7 % (Cl: 16.7% to 34.7%) (p= 0.73). The standard deviation for all patients, calculated from the mean variance of each individual scan sessions, was 199.8 ml/min for UDT and 47.6 ml/min for VFI (p = 0.002). VFI volume flow values were not significantly different from the corresponding estimates obtained using UDT, and VFI measurements were more precise than UDT. The study indicates that VFI can be used for surveillance of volume flow.

Numerical investigation of saturated upward flow boiling of water in a vertical tube using VOF model: effect of different boundary conditions

NASA Astrophysics Data System (ADS)

Hasanpour, B.; Irandoost, M. S.; Hassani, M.; Kouhikamali, R.

2018-01-01

In this paper a numerical simulation of upward two-phase flow evaporation in a vertical tube has been studied by considering water as working fluid. To this end, the computational fluid dynamic simulations of this system are performed with heat and mass transfer mechanisms due to energy transfer during the phase change interaction near the heat transfer surface. The volume of fluid model in an available Eulerian-Eulerian approach based on finite volume method is utilized and the mass source term in conservation of mass equation is implemented using a user defined function. The characteristics of water flow boiling such as void fraction and heat transfer coefficient distribution are investigated. The main cause of fluctuations on heat transfer coefficient and volume fraction is velocity increment in the vapor phase rather than the liquid phase. The case study of this research including convective heat transfer coefficient and tube diameter are considered as a parametric study. The operating conditions are considered at high pressure in saturation temperature and the physical properties of water are determined by considering system's inlet temperature and pressure in saturation conditions. Good agreement is achieved between the numerical and the experimental values of heat transfer coefficients.

Numerical investigation of saturated upward flow boiling of water in a vertical tube using VOF model: effect of different boundary conditions

NASA Astrophysics Data System (ADS)

Hasanpour, B.; Irandoost, M. S.; Hassani, M.; Kouhikamali, R.

2018-07-01

In this paper a numerical simulation of upward two-phase flow evaporation in a vertical tube has been studied by considering water as working fluid. To this end, the computational fluid dynamic simulations of this system are performed with heat and mass transfer mechanisms due to energy transfer during the phase change interaction near the heat transfer surface. The volume of fluid model in an available Eulerian-Eulerian approach based on finite volume method is utilized and the mass source term in conservation of mass equation is implemented using a user defined function. The characteristics of water flow boiling such as void fraction and heat transfer coefficient distribution are investigated. The main cause of fluctuations on heat transfer coefficient and volume fraction is velocity increment in the vapor phase rather than the liquid phase. The case study of this research including convective heat transfer coefficient and tube diameter are considered as a parametric study. The operating conditions are considered at high pressure in saturation temperature and the physical properties of water are determined by considering system's inlet temperature and pressure in saturation conditions. Good agreement is achieved between the numerical and the experimental values of heat transfer coefficients.

Control of respiration-driven retrograde flow in the subdiaphragmatic venous return of the Fontan circulation

PubMed Central

Vukicevic, M; Conover, T; Jaeggli, M; Zhou, J; Pennati, G; Hsia, TY; Figliola, RS

2014-01-01

Respiration influences the subdiaphragmatic venous return in the total cavopulmonary connection (TCPC) of the Fontan circulation whereby both the inferior vena cava (IVC) and hepatic vein flows can experience retrograde motion. Controlling retrograde flows could improve patient outcomes. Using a patient-specific model within a Fontan mock circulatory system with respiration, we inserted a valve into the IVC to examine its effects on local hemodynamics while varying retrograde volumes by changing vascular impedances. A bovine valved conduit reduced IVC retrograde flow to within 3% of antegrade flow in all cases. The valve closed only under conditions supporting retrograde flow and its effects on local hemodynamics increased with larger retrograde volume. Liver and TCPC pressures improved only while the valve leaflets were closed while cycle-averaged pressures improved only slightly (italic>1 mm Hg). Increased pulmonary vascular resistance raised mean circulation pressures but the valve functioned and cardiac output improved and stabilized. Power loss across the TCPC improved by 12–15% (pbold>0.05) with a valve. The effectiveness of valve therapy is dependent on patient vascular impedance. PMID:24814833

Mount Baker lahars and debris flows, ancient, modern, and future

USGS Publications Warehouse

Tucker, David S; Scott, Kevin M.; Grossman, Eric E.; Linneman, Scott

2014-01-01

Holocene lahars and large debris flows (>106 m3) have left recognizable deposits in the Middle Fork Nooksack valley. A debris flow in 2013 resulting from a landslide in a Little Ice Age moraine had an estimated volume of 100,000 m3, yet affected turbidity for the entire length of the river, and produced a slug of sediment that is currently being reworked and remobilized in the river system. Deposits of smaller-volume debris flows, deposited as terraces in the upper valley, may be entirely eroded within a few years. Consequently, the geologic record of small debris flows such as those that occurred in 2013 is probably very fragmentary. Small debris flows may still have significant impacts on hydrology, biology, and human uses of rivers downstream. Impacts include the addition of waves of fine sediment to stream loads, scouring or burying salmon-spawning gravels, forcing unplanned and sudden closure of municipal water intakes, damaging or destroying trail crossings, extending river deltas into estuaries, and adding to silting of harbors near river mouths.

Engine Hydraulic Stability. [injector model for analyzing combustion instability

NASA Technical Reports Server (NTRS)

Kesselring, R. C.; Sprouse, K. M.

1977-01-01

An analytical injector model was developed specifically to analyze combustion instability coupling between the injector hydraulics and the combustion process. This digital computer dynamic injector model will, for any imposed chamber of inlet pressure profile with a frequency ranging from 100 to 3000 Hz (minimum) accurately predict/calculate the instantaneous injector flowrates. The injector system is described in terms of which flow segments enter and leave each pressure node. For each flow segment, a resistance, line lengths, and areas are required as inputs (the line lengths and areas are used in determining inertance). For each pressure node, volume and acoustic velocity are required as inputs (volume and acoustic velocity determine capacitance). The geometric criteria for determining inertances of flow segments and capacitance of pressure nodes was set. Also, a technique was developed for analytically determining time averaged steady-state pressure drops and flowrates for every flow segment in an injector when such data is not known. These pressure drops and flowrates are then used in determining the linearized flow resistance for each line segment of flow.

Traditional Foley drainage systems--do they drain the bladder?

PubMed

Garcia, Maurice M; Gulati, Shelly; Liepmann, Dorian; Stackhouse, G Bennett; Greene, Kirsten; Stoller, Marshall L

2007-01-01

Foley catheters are assumed to drain the bladder to completion. Drainage characteristics of Foley catheter systems are poorly understood. To investigate unrecognized retained urine with Foley catheter drainage systems, bladder volumes of hospitalized patients were measured with bladder scan ultrasound volumetrics. Additionally, an in vitro bench top mock bladder and urinary catheter system was developed to understand the etiology of such residual volumes. A novel drainage tube design that optimizes indwelling catheter drainage was also designed. Bedside bladder ultrasound volumetric studies were performed on patients hospitalized in ward and intensive care unit. If residual urine was identified the drainage tubing was manipulated to facilitate drainage. An ex vivo bladder-urinary catheter model was designed to measure flow rates and pressures within the drainage tubing of a traditional and a novel drainage tube system. A total of 75 patients in the intensive care unit underwent bladder ultrasound volumetrics. Mean residual volume was 96 ml (range 4 to 290). In 75 patients on the hospital ward mean residual volume was 136 ml (range 22 to 647). In the experimental model we found that for every 1 cm in curl height, obstruction pressure increased by 1 cm H2O within the artificial bladder. In contrast, the novel spiral-shaped drainage tube demonstrated rapid (0.5 cc per second), continuous and complete (100%) reservoir drainage in all trials. Traditional Foley catheter drainage systems evacuate the bladder suboptimally. Outflow obstruction is caused by air-locks that develop within curled redundant drainage tubing segments. The novel drainage tubing design eliminates gravity dependent curls and associated air-locks, optimizes flow, and minimizes residual bladder urine.

Experimental observation of the asymmetric instability of intermediate-reduced-volume vesicles in extensional flow.

PubMed

Dahl, Joanna B; Narsimhan, Vivek; Gouveia, Bernardo; Kumar, Sanjay; Shaqfeh, Eric S G; Muller, Susan J

2016-04-20

Vesicles provide an attractive model system to understand the deformation of living cells in response to mechanical forces. These simple, enclosed lipid bilayer membranes are suitable for complementary theoretical, numerical, and experimental analysis. A recent study [Narsimhan, Spann, Shaqfeh, J. Fluid Mech., 2014, 750, 144] predicted that intermediate-aspect-ratio vesicles extend asymmetrically in extensional flow. Upon infinitesimal perturbation to the vesicle shape, the vesicle stretches into an asymmetric dumbbell with a cylindrical thread separating the two ends. While the symmetric stretching of high-aspect-ratio vesicles in extensional flow has been observed and characterized [Kantsler, Segre, Steinberg, Phys. Rev. Lett., 2008, 101, 048101] as well as recapitulated in numerical simulations by Narsimhan et al., experimental observation of the asymmetric stretching has not been reported. In this work, we present results from microfluidic cross-slot experiments observing this instability, along with careful characterization of the flow field, vesicle shape, and vesicle bending modulus. The onset of this shape transition depends on two non-dimensional parameters: reduced volume (a measure of vesicle asphericity) and capillary number (ratio of viscous to bending forces). We observed that every intermediate-reduced-volume vesicle that extends forms a dumbbell shape that is indeed asymmetric. For the subset of the intermediate-reduced-volume regime we could capture experimentally, we present an experimental phase diagram for asymmetric vesicle stretching that is consistent with the predictions of Narsimhan et al.

The effects of Missouri River mainstem reservoir system operations on 2011 flooding using a Precipitation-Runoff Modeling System model: Chapter K in 2011 Floods of the Central United States

USGS Publications Warehouse

Haj, Adel E.; Christiansen, Daniel E.; Viger, Roland J.

2014-01-01

In 2011 the Missouri River Mainstem Reservoir System (Reservoir System) experienced the largest volume of flood waters since the initiation of record-keeping in the nineteenth century. The high levels of runoff from both snowpack and rainfall stressed the Reservoir System’s capacity to control flood waters and caused massive damage and disruption along the river. The flooding and resulting damage along the Missouri River brought increased public attention to the U.S. Army Corps of Engineers (USACE) operation of the Reservoir System. To help understand the effects of Reservoir System operation on the 2011 Missouri River flood flows, the U.S. Geological Survey Precipitation-Runoff Modeling System was used to construct a model of the Missouri River Basin to simulate flows at streamgages and dam locations with the effects of Reservoir System operation (regulation) on flow removed. Statistical tests indicate that the Missouri River Precipitation-Runoff Modeling System model is a good fit for high-flow monthly and annual stream flow estimation. A comparison of simulated unregulated flows and measured regulated flows show that regulation greatly reduced spring peak flow events, consolidated two summer peak flow events to one with a markedly decreased magnitude, and maintained higher than normal base flow beyond the end of water year 2011. Further comparison of results indicate that without regulation, flows greater than those measured would have occurred and been sustained for much longer, frequently in excess of 30 days, and flooding associated with high-flow events would have been more severe.

A Novel Low-Power, High-Performance, Zero-Maintenance Closed-Path Trace Gas Eddy Covariance System with No Water Vapor Dilution or Spectroscopic Corrections

NASA Astrophysics Data System (ADS)

Sargent, S.; Somers, J. M.

2015-12-01

Trace-gas eddy covariance flux measurement can be made with open-path or closed-path analyzers. Traditional closed-path trace-gas analyzers use multipass absorption cells that behave as mixing volumes, requiring high sample flow rates to achieve useful frequency response. The high sample flow rate and the need to keep the multipass cell extremely clean dictates the use of a fine-pore filter that may clog quickly. A large-capacity filter cannot be used because it would degrade the EC system frequency response. The high flow rate also requires a powerful vacuum pump, which will typically consume on the order of 1000 W. The analyzer must measure water vapor for spectroscopic and dilution corrections. Open-path analyzers are available for methane, but not for nitrous oxide. The currently available methane analyzers have low power consumption, but are very large. Their large size degrades frequency response and disturbs the air flow near the sonic anemometer. They require significant maintenance to keep the exposed multipass optical surfaces clean. Water vapor measurements for dilution and spectroscopic corrections require a separate water vapor analyzer. A new closed-path eddy covariance system for measuring nitrous oxide or methane fluxes provides an elegant solution. The analyzer (TGA200A, Campbell Scientific, Inc.) uses a thermoelectrically-cooled interband cascade laser. Its small sample-cell volume and unique sample-cell configuration (200 ml, 1.5 m single pass) provide excellent frequency response with a low-power scroll pump (240 W). A new single-tube Nafion® dryer removes most of the water vapor, and attenuates fluctuations in the residual water vapor. Finally, a vortex intake assembly eliminates the need for an intake filter without adding volume that would degrade system frequency response. Laboratory testing shows the system attenuates the water vapor dilution term by more than 99% and achieves a half-power band width of 3.5 Hz.

SEPAC flight software detailed design specifications, volume 1

NASA Technical Reports Server (NTRS)

1982-01-01

The detailed design specifications (as built) for the SEPAC Flight Software are defined. The design includes a description of the total software system and of each individual module within the system. The design specifications describe the decomposition of the software system into its major components. The system structure is expressed in the following forms: the control-flow hierarchy of the system, the data-flow structure of the system, the task hierarchy, the memory structure, and the software to hardware configuration mapping. The component design description includes details on the following elements: register conventions, module (subroutines) invocaton, module functions, interrupt servicing, data definitions, and database structure.

Further Development and Application of GEOFRAC-FLOW to a Geothermal Reservoir

DOE Office of Scientific and Technical Information (OSTI.GOV)

Einstein, Herbert; Vecchiarelli, Alessandra

2014-05-01

GEOFRAC is a three-dimensional, geology-based, geometric-mechanical, hierarchical, stochastic model of natural rock fracture systems. The main characteristics of GEOFRAC are its use of statistical input representing fracture patterns in the field in form of the fracture intensity P32 (fracture area per volume) and the best estimate fracture size E(A). This information can be obtained from boreholes or scanlines on the surface, on the one hand, and from window sampling of fracture traces on the other hand. In the context of this project, “Recovery Act - Decision Aids for Geothermal Systems”, GEOFRAC was further developed into GEOFRAC-FLOW as has been reportedmore » in the reports, “Decision Aids for Geothermal Systems - Fracture Pattern Modelling” and “Decision Aids for Geothermal Systems - Fracture Flow Modeling”. GEOFRAC-FLOW allows one to determine preferred, interconnected fracture paths and the flow through them.« less

Particle Streak Anemometry: A New Method for Proximal Flow Sensing from Aircraft

NASA Astrophysics Data System (ADS)

Nichols, T. W.

Accurate sensing of relative air flow direction from fixed-wing small unmanned aircraft (sUAS) is challenging with existing multi-hole pitot-static and vane systems. Sub-degree direction accuracy is generally not available on such systems and disturbances to the local flow field, induced by the airframe, introduce an additional error source. An optical imaging approach to make a relative air velocity measurement with high-directional accuracy is presented. Optical methods offer the capability to make a proximal measurement in undisturbed air outside of the local flow field without the need to place sensors on vulnerable probes extended ahead of the aircraft. Current imaging flow analysis techniques for laboratory use rely on relatively thin imaged volumes and sophisticated hardware and intensity thresholding in low-background conditions. A new method is derived and assessed using a particle streak imaging technique that can be implemented with low-cost commercial cameras and illumination systems, and can function in imaged volumes of arbitrary depth with complex background signal. The new technique, referred to as particle streak anemometry (PSA) (to differentiate from particle streak velocimetry which makes a field measurement rather than a single bulk flow measurement) utilizes a modified Canny Edge detection algorithm with a connected component analysis and principle component analysis to detect streak ends in complex imaging conditions. A linear solution for the air velocity direction is then implemented with a random sample consensus (RANSAC) solution approach. A single DOF non-linear, non-convex optimization problem is then solved for the air speed through an iterative approach. The technique was tested through simulation and wind tunnel tests yielding angular accuracies under 0.2 degrees, superior to the performance of existing commercial systems. Air speed error standard deviations varied from 1.6 to 2.2 m/s depending on the techniques of implementation. While air speed sensing is secondary to accurate flow direction measurement, the air speed results were in line with commercial pitot static systems at low speeds.

Green roof hydrologic performance and modeling: a review.

PubMed

Li, Yanling; Babcock, Roger W

2014-01-01

Green roofs reduce runoff from impervious surfaces in urban development. This paper reviews the technical literature on green roof hydrology. Laboratory experiments and field measurements have shown that green roofs can reduce stormwater runoff volume by 30 to 86%, reduce peak flow rate by 22 to 93% and delay the peak flow by 0 to 30 min and thereby decrease pollution, flooding and erosion during precipitation events. However, the effectiveness can vary substantially due to design characteristics making performance predictions difficult. Evaluation of the most recently published study findings indicates that the major factors affecting green roof hydrology are precipitation volume, precipitation dynamics, antecedent conditions, growth medium, plant species, and roof slope. This paper also evaluates the computer models commonly used to simulate hydrologic processes for green roofs, including stormwater management model, soil water atmosphere and plant, SWMS-2D, HYDRUS, and other models that are shown to be effective for predicting precipitation response and economic benefits. The review findings indicate that green roofs are effective for reduction of runoff volume and peak flow, and delay of peak flow, however, no tool or model is available to predict expected performance for any given anticipated system based on design parameters that directly affect green roof hydrology.

On the feasibility to conduct gradient liquid chromatography separations in narrow-bore columns at pressures up to 2000bar.

PubMed

De Pauw, Ruben; Swier, Tim; Degreef, Bart; Desmet, Gert; Broeckhoven, Ken

2016-11-18

The limits in operating pressures are extended for narrow-bore columns in gradient elution up to 2000bar. As the required pumps for these pressures are incompatible with common chromatographic solvents and are not suitable to apply a mobile phase composition gradient, a mobile phase delivery and injection system is described and experimentally validated which allows to use any possible chromatographic solvent in isocratic and gradient elution. The mobile phase delivery and injection system also allows to perform multiple separations without the need to depressurize the column. This system consists out of 5 dual on/off valves and two large volume loops in which the gradient and equilibration volume of initial mobile phase are loaded by a commercial liquid chromatography pump. The loops are then flushed toward the column at extreme pressures. The mobile phase delivery and injection system is first evaluated in isocratic elution and shows a comparable performance to a state-of-the-art commercial flow-through-needle injector but with twice the pressure rating. Distortion of the loaded gradient by dispersion in the gradient storage loop is studied. The effect of the most important parameters (such as flow rate, pressure and gradient steepness) is experimentally investigated. Different gradient steepnesses and volumes can be applied at different flow rates and operating pressures with a good repeatability. Due to the isobaric operation of the pumps, the gradient is monitored in real-time by a mass flow meter installed at the detector outlet. The chromatograms are then converted from time to volume-base. A separation of a 19-compound sample is performed on a 300×2.1mm column at 1000bar and on a 600×2.1mm column at 2000bar. The peak capacity was found to increase from 141 to 199 and thus scales with L as is predicted by theory. This allows to conclude that the inlet pressure for narrow-bore columns in gradient elution can be increased up to 2000bar without fundamental pressure-induced limitations. Copyright © 2016 Elsevier B.V. All rights reserved.

The down canyon evolution of submarine sediment density flows

NASA Astrophysics Data System (ADS)

Parsons, D. R.; Barry, J.; Clare, M. A.; Cartigny, M.; Chaffey, M. R.; Gales, J. A.; Gwiazda, R.; Maier, K. L.; McGann, M.; Paull, C. K.; O'Reilly, T. C.; Rosenberger, K. J.; Simmons, S.; Sumner, E. J.; Talling, P.; Xu, J.

2017-12-01

Submarine density flows, known as turbidity currents, transfer globally significant volumes of terrestrial and shelf sediments, organic carbon, nutrients and fresher-water into the deep ocean. Understanding such flows has wide implications for global organic carbon cycling, the functioning of deep-sea ecosystems, seabed infrastructure hazard assessments, and interpreting geological archives of Earth history. Only river systems transport comparable volumes of sediment over such large areas of the globe. Despite their clear importance, there are remarkably few direct measurements of these oceanic turbidity currents in action. Here we present results from the multi-institution Coordinated Canyon Experiment (CCE) which deployed multiple moorings along the axis of Monterey Canyon (offshore California). An array of six moorings, with downward looking acoustic Doppler current profilers (ADCP) were positioned along the canyon axis from 290 m to 1850 m water depth. The ADCPs reveal the internal flow structure of submarine density flows at each site. We use a novel inversion method to reconstruct the suspended sediment concentration and flow stratification field during each event. Together the six moorings provide the first ever views of the internal structural evolution of turbidity current events as they evolve down system. Across the total 18-month period of deployment at least 15 submarine sediment density flows were measured with velocities up to 8.1 m/sec, with three of these flows extending 50 kms down the canyon beyond the 1850 m water depth mooring. We use these novel data to highlight the controls on ignition, interval structure and collapse of individual events and discuss the implications for the functioning and deposits produced by these enigmatic flows.

Simulation of streamflow, evapotranspiration, and groundwater recharge in the Lower Frio River watershed, south Texas, 1961-2008

USGS Publications Warehouse

Lizarraga, Joy S.; Ockerman, Darwin J.

2011-01-01

The U.S. Geological Survey, in cooperation with the U.S. Army Corps of Engineers, Fort Worth District; the City of Corpus Christi; the Guadalupe-Blanco River Authority; the San Antonio River Authority; and the San Antonio Water System, configured, calibrated, and tested a watershed model for a study area consisting of about 5,490 mi2 of the Frio River watershed in south Texas. The purpose of the model is to contribute to the understanding of watershed processes and hydrologic conditions in the lower Frio River watershed. The model simulates streamflow, evapotranspiration (ET), and groundwater recharge by using a numerical representation of physical characteristics of the landscape, and meteorological and streamflow data. Additional time-series inputs to the model include wastewater-treatment-plant discharges, surface-water withdrawals, and estimated groundwater inflow from Leona Springs. Model simulations of streamflow, ET, and groundwater recharge were done for various periods of record depending upon available measured data for input and comparison, starting as early as 1961. Because of the large size of the study area, the lower Frio River watershed was divided into 12 subwatersheds; separate Hydrological Simulation Program-FORTRAN models were developed for each subwatershed. Simulation of the overall study area involved running simulations in downstream order. Output from the model was summarized by subwatershed, point locations, reservoir reaches, and the Carrizo-Wilcox aquifer outcrop. Four long-term U.S. Geological Survey streamflow-gaging stations and two short-term streamflow-gaging stations were used for streamflow model calibration and testing with data from 1991-2008. Calibration was based on data from 2000-08, and testing was based on data from 1991-99. Choke Canyon Reservoir stage data from 1992-2008 and monthly evaporation estimates from 1999-2008 also were used for model calibration. Additionally, 2006-08 ET data from a U.S. Geological Survey meteorological station in Medina County were used for calibration. Streamflow and ET calibration were considered good or very good. For the 2000-08 calibration period, total simulated flow volume and the flow volume of the highest 10 percent of simulated daily flows were calibrated to within about 10 percent of measured volumes at six U.S. Geological Survey streamflow-gaging stations. The flow volume of the lowest 50 percent of daily flows was not simulated as accurately but represented a small percent of the total flow volume. The model-fit efficiency for the weekly mean streamflow during the calibration periods ranged from 0.60 to 0.91, and the root mean square error ranged from 16 to 271 percent of the mean flow rate. The simulated total flow volumes during the testing periods at the long-term gaging stations exceeded the measured total flow volumes by approximately 22 to 50 percent at three stations and were within 7 percent of the measured total flow volumes at one station. For the longer 1961-2008 simulation period at the long-term stations, simulated total flow volumes were within about 3 to 18 percent of measured total flow volumes. The calibrations made by using Choke Canyon reservoir volume for 1992-2008, reservoir evaporation for 1999-2008, and ET in Medina County for 2006-08, are considered very good. Model limitations include possible errors related to model conceptualization and parameter variability, lack of data to better quantify certain model inputs, and measurement errors. Uncertainty regarding the degree to which available rainfall data represent actual rainfall is potentially the most serious source of measurement error. A sensitivity analysis was performed for the Upper San Miguel subwatershed model to show the effect of changes to model parameters on the estimated mean recharge, ET, and surface runoff from that part of the Carrizo-Wilcox aquifer outcrop. Simulated recharge was most sensitive to the changes in the lower-zone ET (LZ

Charging and Transport Dynamics of a Flow-Through Electrode Capacitive Deionization System.

PubMed

Qu, Yatian; Campbell, Patrick G; Hemmatifar, Ali; Knipe, Jennifer M; Loeb, Colin K; Reidy, John J; Hubert, Mckenzie A; Stadermann, Michael; Santiago, Juan G

2018-01-11

We present a study of the interplay among electric charging rate, capacitance, salt removal, and mass transport in "flow-through electrode" capacitive deionization (CDI) systems. We develop two models describing coupled transport and electro-adsorption/desorption which capture salt removal dynamics. The first model is a simplified, unsteady zero-dimensional volume-averaged model which identifies dimensionless parameters and figures of merits associated with cell performance. The second model is a higher fidelity area-averaged model which captures both spatial and temporal responses of charging. We further conducted an experimental study of these dynamics and considered two salt transport regimes: (1) advection-limited regime and (2) dispersion-limited regime. We use these data to validate models. The study shows that, in the advection-limited regime, differential charge efficiency determines the salt adsorption at the early stage of the deionization process. Subsequently, charging transitions to a quasi-steady state where salt removal rate is proportional to applied current scaled by the inlet flow rate. In the dispersion-dominated regime, differential charge efficiency, cell volume, and diffusion rates govern adsorption dynamics and flow rate has little effect. In both regimes, the interplay among mass transport rate, differential charge efficiency, cell capacitance, and (electric) charging current governs salt removal in flow-through electrode CDI.

Noncontact diffuse correlation tomography of human breast tumor

PubMed Central

He, Lian; Lin, Yu; Huang, Chong; Irwin, Daniel; Szabunio, Margaret M.; Yu, Guoqiang

2015-01-01

Abstract. Our first step to adapt our recently developed noncontact diffuse correlation tomography (ncDCT) system for three-dimensional (3-D) imaging of blood flow distribution in human breast tumors is reported. A commercial 3-D camera was used to obtain breast surface geometry, which was then converted to a solid volume mesh. An ncDCT probe scanned over a region of interest on the mesh surface and the measured boundary data were combined with a finite element framework for 3-D image reconstruction of blood flow distribution. This technique was tested in computer simulations and in vivo human breasts with low-grade carcinoma. Results from computer simulations suggest that relatively high accuracy can be achieved when the entire tumor is within the sensitive region of diffuse light. Image reconstruction with a priori knowledge of the tumor volume and location can significantly improve the accuracy in recovery of tumor blood flow contrasts. In vivo imaging results from two breast carcinomas show higher average blood flow contrasts (5.9- and 10.9-fold) in the tumor regions compared to the surrounding tissues, which are comparable with previous findings using diffuse correlation spectroscopy. The ncDCT system has the potential to image blood flow distributions in soft and vulnerable tissues without distorting tissue hemodynamics. PMID:26259706

Optimization of the convection volume in online post-dilution haemodiafiltration: practical and technical issues

PubMed Central

Chapdelaine, Isabelle; de Roij van Zuijdewijn, Camiel L.M.; Mostovaya, Ira M.; Lévesque, Renée; Davenport, Andrew; Blankestijn, Peter J.; Wanner, Christoph; Nubé, Menso J.; Grooteman, Muriel P.C.

2015-01-01

In post-dilution online haemodiafiltration (ol-HDF), a relationship has been demonstrated between the magnitude of the convection volume and survival. However, to achieve high convection volumes (>22 L per session) detailed notion of its determining factors is highly desirable. This manuscript summarizes practical problems and pitfalls that were encountered during the quest for high convection volumes. Specifically, it addresses issues such as type of vascular access, needles, blood flow rate, recirculation, filtration fraction, anticoagulation and dialysers. Finally, five of the main HDF systems in Europe are briefly described as far as HDF prescription and optimization of the convection volume is concerned. PMID:25815176

Quasi-2D Unsteady Flow Solver Module for Rocket Engine and Propulsion System Simulations

DTIC Science & Technology

2006-06-14

Conference, Sacramento, CA, 9-12 July 2006. 14. ABSTRACT A new quasi-two-dimensional procedure is presented for the transient solution of real-fluid flows...solution procedures is being developed in parallel to provide verification test cases. The solution procedure for both codes is coupled with a state-of...Davis, Davis, CA, 95616 A new quasi-two-dimensional procedure is presented for the transient solution of real- fluid flows in lines and volumes

GASFLOW: A Computational Fluid Dynamics Code for Gases, Aerosols, and Combustion, Volume 3: Assessment Manual

DOE Office of Scientific and Technical Information (OSTI.GOV)

Müller, C.; Hughes, E. D.; Niederauer, G. F.

1998-10-01

Los Alamos National Laboratory (LANL) and Forschungszentrum Karlsruhe (FzK) are developing GASFLOW, a three-dimensional (3D) fluid dynamics field code as a best- estimate tool to characterize local phenomena within a flow field. Examples of 3D phenomena include circulation patterns; flow stratification; hydrogen distribution mixing and stratification; combustion and flame propagation; effects of noncondensable gas distribution on local condensation and evaporation; and aerosol entrainment, transport, and deposition. An analysis with GASFLOW will result in a prediction of the gas composition and discrete particle distribution in space and time throughout the facility and the resulting pressure and temperature loadings on the wallsmore » and internal structures with or without combustion. A major application of GASFLOW is for predicting the transport, mixing, and combustion of hydrogen and other gases in nuclear reactor containment and other facilities. It has been applied to situations involving transporting and distributing combustible gas mixtures. It has been used to study gas dynamic behavior in low-speed, buoyancy-driven flows, as well as sonic flows or diffusion dominated flows; and during chemically reacting flows, including deflagrations. The effects of controlling such mixtures by safety systems can be analyzed. The code version described in this manual is designated GASFLOW 2.1, which combines previous versions of the United States Nuclear Regulatory Commission code HMS (for Hydrogen Mixing Studies) and the Department of Energy and FzK versions of GASFLOW. The code was written in standard Fortran 90. This manual comprises three volumes. Volume I describes the governing physical equations and computational model. Volume II describes how to use the code to set up a model geometry, specify gas species and material properties, define initial and boundary conditions, and specify different outputs, especially graphical displays. Sample problems are included. Volume III contains some of the assessments performed by LANL and FzK« less

Lung function in North American Indian children: reference standards for spirometry, maximal expiratory flow volume curves, and peak expiratory flow.

PubMed

Wall, M A; Olson, D; Bonn, B A; Creelman, T; Buist, A S

1982-02-01

Reference standards of lung function was determined in 176 healthy North American Indian children (94 girls, 82 boys) 7 to 18 yr of age. Spirometry, maximal expiratory flow volume curves, and peak expiratory flow rate were measured using techniques and equipment recommended by the American Thoracic Society. Standing height was found to be an accurate predictor of lung function, and prediction equations for each lung function variable are presented using standing height as the independent variable. Lung volumes and expiratory flow rates in North American Indian children were similar to those previously reported for white and Mexican-American children but were greater than those in black children. In both boys and girls, lung function increased in a curvilinear fashion. Volume-adjusted maximal expiratory flow rates after expiring 50 or 75% of FVC tended to decrease in both sexes as age and height increased. Our maximal expiratory flow volume curve data suggest that as North American Indian children grow, lung volume increases at a slightly faster rate than airway size does.

Automated gas chromatography

DOEpatents

Mowry, C.D.; Blair, D.S.; Rodacy, P.J.; Reber, S.D.

1999-07-13

An apparatus and process for the continuous, near real-time monitoring of low-level concentrations of organic compounds in a liquid, and, more particularly, a water stream. A small liquid volume of flow from a liquid process stream containing organic compounds is diverted by an automated process to a heated vaporization capillary where the liquid volume is vaporized to a gas that flows to an automated gas chromatograph separation column to chromatographically separate the organic compounds. Organic compounds are detected and the information transmitted to a control system for use in process control. Concentrations of organic compounds less than one part per million are detected in less than one minute. 7 figs.

Feasibility study for a numerical aerodynamic simulation facility. Volume 2: Hardware specifications/descriptions

NASA Technical Reports Server (NTRS)

Green, F. M.; Resnick, D. R.

1979-01-01

An FMP (Flow Model Processor) was designed for use in the Numerical Aerodynamic Simulation Facility (NASF). The NASF was developed to simulate fluid flow over three-dimensional bodies in wind tunnel environments and in free space. The facility is applicable to studying aerodynamic and aircraft body designs. The following general topics are discussed in this volume: (1) FMP functional computer specifications; (2) FMP instruction specification; (3) standard product system components; (4) loosely coupled network (LCN) specifications/description; and (5) three appendices: performance of trunk allocation contention elimination (trace) method, LCN channel protocol and proposed LCN unified second level protocol.

USM3D Predictions of Supersonic Nozzle Flow

NASA Technical Reports Server (NTRS)

Carter, Melissa B.; Elmiligui, Alaa A.; Campbell, Richard L.; Nayani, Sudheer N.

2014-01-01

This study focused on the NASA Tetrahedral Unstructured Software System CFD code (USM3D) capability to predict supersonic plume flow. Previous studies, published in 2004 and 2009, investigated USM3D's results versus historical experimental data. This current study continued that comparison however focusing on the use of the volume souring to capture the shear layers and internal shock structure of the plume. This study was conducted using two benchmark axisymmetric supersonic jet experimental data sets. The study showed that with the use of volume sourcing, USM3D was able to capture and model a jet plume's shear layer and internal shock structure.

Automated gas chromatography

DOEpatents

Mowry, Curtis D.; Blair, Dianna S.; Rodacy, Philip J.; Reber, Stephen D.

1999-01-01

An apparatus and process for the continuous, near real-time monitoring of low-level concentrations of organic compounds in a liquid, and, more particularly, a water stream. A small liquid volume of flow from a liquid process stream containing organic compounds is diverted by an automated process to a heated vaporization capillary where the liquid volume is vaporized to a gas that flows to an automated gas chromatograph separation column to chromatographically separate the organic compounds. Organic compounds are detected and the information transmitted to a control system for use in process control. Concentrations of organic compounds less than one part per million are detected in less than one minute.

Radial flow pulse jet mixer

DOEpatents

VanOsdol, John G.

2013-06-25

The disclosure provides a pulse jet mixing vessel for mixing a plurality of solid particles. The pulse jet mixing vessel is comprised of a sludge basin, a flow surface surrounding the sludge basin, and a downcoming flow annulus between the flow surface and an inner shroud. The pulse jet mixing vessel is additionally comprised of an upper vessel pressurization volume in fluid communication with the downcoming flow annulus, and an inner shroud surge volume separated from the downcoming flow annulus by the inner shroud. When the solid particles are resting on the sludge basin and a fluid such as water is atop the particles and extending into the downcoming flow annulus and the inner shroud surge volume, mixing occurs by pressurization of the upper vessel pressurization volume, generating an inward radial flow over the flow surface and an upwash jet at the center of the sludge basin.

A risk-based framework to assess long-term effects of policy and water supply changes on water resources systems

NASA Astrophysics Data System (ADS)

Hassanzadeh, Elmira; Elshorbagy, Amin; Wheater, Howard; Gober, Patricia

2015-04-01

Climate uncertainty can affect water resources availability and management decisions. Sustainable water resources management therefore requires evaluation of policy and management decisions under a wide range of possible future water supply conditions. This study proposes a risk-based framework to integrate water supply uncertainty into a forward-looking decision making context. To apply this framework, a stochastic reconstruction scheme is used to generate a large ensemble of flow series. For the Rocky Mountain basins considered here, two key characteristics of the annual hydrograph are its annual flow volume and the timing of the seasonal flood peak. These are perturbed to represent natural randomness and potential changes due to future climate. 30-year series of perturbed flows are used as input to the SWAMP model - an integrated water resources model that simulates regional water supply-demand system and estimates economic productivity of water and other sustainability indicators, including system vulnerability and resilience. The simulation results are used to construct 2D-maps of net revenue of a particular water sector; e.g., hydropower, or for all sectors combined. Each map cell represents a risk scenario of net revenue based on a particular annual flow volume, timing of the peak flow, and 200 stochastic realizations of flow series. This framework is demonstrated for a water resources system in the Saskatchewan River Basin (SaskRB) in Saskatchewan, Canada. Critical historical drought sequences, derived from tree-ring reconstructions of several hundred years of annual river flows, are used to evaluate the system's performance (net revenue risk) under extremely low flow conditions and also to locate them on the previously produced 2D risk maps. This simulation and analysis framework is repeated under various reservoir operation strategies (e.g., maximizing flood protection or maximizing water supply security); development proposals, such as irrigation expansion; and change in energy prices. Such risk-based analysis demonstrates relative reduction/increase of risk associated with management and policy decisions and allow decision makers to explore the relative importance of policy versus natural water supply change in a water resources system.

Seals/Secondary Fluid Flows Workshop 1997; Volume I

NASA Technical Reports Server (NTRS)

Hendricks, Robert C. (Editor)

2006-01-01

The 1997 Conference provided discussions and data on (a) program overviews, (b) developments in seals and secondary air management systems, (c) interactive seals flows with secondary air or fluid flows and powerstream flows, (d) views of engine externals and limitations, (e) high speed engine research sealing needs and demands, and (f) a short course on engine design development margins. Sealing concepts discussed include, mechanical rim and cavity seals, leaf, finger, air/oil, rope, floating-brush, floating-T-buffer, and brush seals. Engine externals include all components of engine fluid systems, sensors and their support structures that lie within or project through the nacelle. The clean features of the nacelle belie the minefield of challenges and opportunities that lie within. Seals; Secondary air flows; Rotordynamics; Gas turbine; Aircraft; CFD; Testing; Turbomachinery

Simulation of natural flows in major river basins in Alabama

USGS Publications Warehouse

Hunt, Alexandria M.; García, Ana María

2014-01-01

The Office of Water Resources (OWR) in the Alabama Department of Economic and Community Affairs (ADECA) is charged with the assessment of the State’s water resources. This study developed a watershed model for the major river basins that are within Alabama or that cross Alabama’s borders, which serves as a planning tool for water-resource decisionmakers. The watershed model chosen to assess the natural amount of available water was the Precipitation-Runoff Modeling System (PRMS). Models were configured and calibrated for the following four river basins: Mobile, Gulf of Mexico, Middle Tennessee, and Chattahoochee. These models required calibrating unregulated U.S. Geological Survey (USGS) streamflow gaging stations to estimate natural flows, with emphases on low-flow calibration. The target calibration criteria required the errors be within the range of: (1) ±10 percent for total-streamflow volume, (2) ±10 percent for low-flow volume, (3) ±15 percent for high-flow volume, (4) ±30 percent for summer volume, and (5) above 0.5 for the correlation coefficient (R2). Seventy-one of the 90 calibration stations in the watershed models for the four major river basins within Alabama met the target calibration criteria. Variability in the model performance can be attributed to limitations in correctly representing certain hydrologic conditions that are characterized by some of the ecoregions in Alabama. Ecoregions consisting of predominantly clayey soils and (or) low topographic relief yield less successful calibration results, whereas ecoregions consisting of loamy and sandy soils and (or) high topographic relief yield more successful calibration results. Results indicate that the model does well in hilly regions with sandy soils because of rapid surface runoff and more direct interaction with subsurface flow.

In vitro validation of a Pitot-based flow meter for the measurement of respiratory volume and flow in large animal anaesthesia.

PubMed

Moens, Yves P S; Gootjes, Peter; Ionita, Jean-Claude; Heinonen, Erkki; Schatzmann, Urs

2009-05-01

To remodel and validate commercially available monitors and their Pitot tube-based flow sensors for use in large animals, using in vitro techniques. Prospective, in vitro experiment. Both the original and the remodelled sensor were studied with a reference flow generator. Measurements were taken of the static flow-pressure relationship and linearity of the flow signal. Sensor airway resistance was calculated. Following recalibration of the host monitor, volumes ranging from 1 to 7 L were generated by a calibration syringe, and bias and precision of spirometric volume was determined. Where manual recalibration was not available, a conversion factor for volume measurement was determined. The influence of gas composition mixture and peak flow on the conversion factor was studied. Both the original and the remodelled sensor showed similar static flow-pressure relationships and linearity of the flow signal. Mean bias (%) of displayed values compared with the reference volume of 3, 5 and 7 L varied between -0.4% and +2.4%, and this was significantly smaller than that for 1 L (4.8% to +5.0%). Conversion factors for 3, 5 and 7 L were very similar (mean 6.00 +/- 0.2, range 5.91-6.06) and were not significantly influenced by the gas mixture used. Increasing peak flow caused a small decrease in the conversion factor. Volume measurement error and conversion factors for inspiration and expiration were close to identity. The combination of the host monitor with the remodelled flow sensor allowed accurate in vitro measurement of flows and volumes in a range expected during large animal anaesthesia. This combination has potential as a reliable spirometric monitor for use during large animal anaesthesia.

Tile drainage phosphorus loss with long-term consistent cropping systems and fertilization.

PubMed

Zhang, T Q; Tan, C S; Zheng, Z M; Drury, C F

2015-03-01

Phosphorus (P) loss in tile drainage water may vary with agricultural practices, and the impacts are often hard to detect with short-term studies. We evaluated the effects of long-term (≥43 yr) cropping systems (continuous corn [CC], corn-oats-alfalfa-alfalfa rotation [CR], and continuous grass [CS]) and fertilization (fertilization [F] vs. no-fertilization [NF]) on P loss in tile drainage water from a clay loam soil over a 4-yr period. Compared with NF, long-term fertilization increased concentrations and losses of dissolved reactive P (DRP), dissolved unreactive P (DURP), and total P (TP) in tile drainage water, with the increments following the order: CS > CR > CC. Dissolved P (dissolved reactive P [DRP] and dissolved unreactive P [DURP]) was the dominant P form in drainage outflow, accounting for 72% of TP loss under F-CS, whereas particulate P (PP) was the major form of TP loss under F-CC (72%), F-CR (62%), NF-CS (66%), NF-CC (74%), and NF-CR (72%). Dissolved unreactive P played nearly equal roles as DRP in P losses in tile drainage water. Stepwise regression analysis showed that the concentration of P (DRP, DURP, and PP) in tile drainage flow, rather than event flow volume, was the most important factor contributing to P loss in tile drainage water, although event flow volume was more important in PP loss than in dissolved P loss. Continuous grass significantly increased P loss by increasing P concentration and flow volume of tile drainage water, especially under the fertilization treatment. Long-term grasslands may become a significant P source in tile-drained systems when they receive regular P addition. Copyright © by the American Society of Agronomy, Crop Science Society of America, and Soil Science Society of America, Inc.

Analysis of Dual Mode Systems in an Urban Area : Volume 4C. Program Documentation of the Transportation Economic Analysis Model (concluded)

DOT National Transportation Integrated Search

1973-12-01

The contents are: Appendix B - Detailed flow diagrams - new systems cost program; Appendix C and D - Typical input and output data - new system cost program; Appendix E - Compiled listings - highway transit cost program; Appendix F and G - Typical in...

Methods and new approaches to the calculation of physiological parameters by videodensitometry

NASA Technical Reports Server (NTRS)

Kedem, D.; Londstrom, D. P.; Rhea, T. C., Jr.; Nelson, J. H.; Price, R. R.; Smith, C. W.; Graham, T. P., Jr.; Brill, A. B.; Kedem, D.

1976-01-01

A complex system featuring a video-camera connected to a video disk, cine (medical motion picture) camera and PDP-9 computer with various input/output facilities has been developed. This system enables the performance of quantitative analysis of various functions recorded in clinical studies. Several studies are described, such as heart chamber volume calculations, left ventricle ejection fraction, blood flow through the lungs and also the possibility of obtaining information about blood flow and constrictions in small cross-section vessels

Investigations of microwave plasmas - Applications in electrothermal thruster systems

NASA Technical Reports Server (NTRS)

Haraburda, Scott S.; Hawley, Martin C.

1989-01-01

Experimental studies which have been conducted to develop understanding of plasma processes used for spacecraft propulsion are reviewed. The techniques discussed are calorimetry and volume measurements using the TM 011 and TM 012 modes in the microwave cavity system. The use of plasmas in electrical propulsion and microwave induction is reviewed. Plasma containment, microwave power production, energy distribution, and the pressure and flow dependence of the energy distribution are addressed. The plasma dimensions and their dependence on pressure, flow, and power are considered.

Investigations of microwave plasmas - Applications in electrothermal thruster systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Haraburda, S.S.; Hawley, M.C.

1989-01-01

Experimental studies which have been conducted to develop understanding of plasma processes used for spacecraft propulsion are reviewed. The techniques discussed are calorimetry and volume measurements using the TM 011 and TM 012 modes in the microwave cavity system. The use of plasmas in electrical propulsion and microwave induction is reviewed. Plasma containment, microwave power production, energy distribution, and the pressure and flow dependence of the energy distribution are addressed. The plasma dimensions and their dependence on pressure, flow, and power are considered. 10 refs.

Coastal Modeling System: Mathematical Formulations and Numerical Methods

DTIC Science & Technology

2014-03-01

sediment transport , and morphology change. The CMS was designed and developed for coastal inlets and navigation applications, including channel...numerical methods of hydrodynamic, salinity and sediment transport , and morphology change model CMS-Flow. The CMS- Flow uses the Finite Volume...and the influence of coastal structures. The implicit hydrodynamic model is coupled to a nonequilibrium transport model of multiple-sized total

Hand-Portable Gradient Capillary Liquid Chromatography Pumping System.

PubMed

Sharma, Sonika; Plistil, Alex; Barnett, Hal E; Tolley, H Dennis; Farnsworth, Paul B; Stearns, Stanley D; Lee, Milton L

2015-10-20

In this work, a novel splitless nanoflow gradient generator integrated with a stop-flow injector was developed and evaluated using an on-column UV-absorption detector. The gradient pumping system consisted of two nanoflow pumps controlled by micro stepper motors, a mixer connected to a serpentine tube, and a high-pressure valve. The gradient system weighed only 4 kg (9 lbs) and could generate up to 55 MPa (8000 psi) pressure. The system could operate using a 24 V DC battery and required 1.2 A for operation. The total volume capacity of the pump was 74 μL, and a sample volume of 60 nL could be injected. The system provided accurate nanoflow rates as low as 10 nL/min without employing a splitter, making it ideal for capillary column use. The gradient dwell volume was calculated to be 1.3 μL, which created a delay of approximately 4 min with a typical flow rate of 350 nL/min. Gradient performance was evaluated for gradient step accuracy, and excellent reproducibility was obtained in day-to-day experiments (RSD < 1.2%, n = 4). Linear gradient reproducibility was tested by separating a three-component pesticide mixture on a poly(ethylene glycol) diacrylate (PEGDA) monolithic column. The retention time reproducibility was very good in run-to-run experiments (RSD < 1.42%, n = 4). Finally, excellent separation of five phenols was demonstrated using the nanoflow gradient system.

Process for heating coal-oil slurries

DOEpatents

Braunlin, W.A.; Gorski, A.; Jaehnig, L.J.; Moskal, C.J.; Naylor, J.D.; Parimi, K.; Ward, J.V.

1984-01-03

Controlling gas to slurry volume ratio to achieve a gas holdup of about 0.4 when heating a flowing coal-oil slurry and a hydrogen containing gas stream allows operation with virtually any coal to solvent ratio and permits operation with efficient heat transfer and satisfactory pressure drops. The critical minimum gas flow rate for any given coal-oil slurry will depend on numerous factors such as coal concentration, coal particle size distribution, composition of the solvent (including recycle slurries), and type of coal. Further system efficiency can be achieved by operating with multiple heating zones to provide a high heat flux when the apparent viscosity of the gas saturated slurry is highest. Operation with gas flow rates below the critical minimum results in system instability indicated by temperature excursions in the fluid and at the tube wall, by a rapid increase and then decrease in overall pressure drop with decreasing gas flow rate, and by increased temperature differences between the temperature of the bulk fluid and the tube wall. At the temperatures and pressures used in coal liquefaction preheaters the coal-oil slurry and hydrogen containing gas stream behaves essentially as a Newtonian fluid at shear rates in excess of 150 sec[sup [minus]1]. The gas to slurry volume ratio should also be controlled to assure that the flow regime does not shift from homogeneous flow to non-homogeneous flow. Stable operations have been observed with a maximum gas holdup as high as 0.72. 29 figs.

Process for heating coal-oil slurries

DOEpatents

Braunlin, Walter A.; Gorski, Alan; Jaehnig, Leo J.; Moskal, Clifford J.; Naylor, Joseph D.; Parimi, Krishnia; Ward, John V.

1984-01-03

Controlling gas to slurry volume ratio to achieve a gas holdup of about 0.4 when heating a flowing coal-oil slurry and a hydrogen containing gas stream allows operation with virtually any coal to solvent ratio and permits operation with efficient heat transfer and satisfactory pressure drops. The critical minimum gas flow rate for any given coal-oil slurry will depend on numerous factors such as coal concentration, coal particle size distribution, composition of the solvent (including recycle slurries), and type of coal. Further system efficiency can be achieved by operating with multiple heating zones to provide a high heat flux when the apparent viscosity of the gas saturated slurry is highest. Operation with gas flow rates below the critical minimum results in system instability indicated by temperature excursions in the fluid and at the tube wall, by a rapid increase and then decrease in overall pressure drop with decreasing gas flow rate, and by increased temperature differences between the temperature of the bulk fluid and the tube wall. At the temperatures and pressures used in coal liquefaction preheaters the coal-oil slurry and hydrogen containing gas stream behaves essentially as a Newtonian fluid at shear rates in excess of 150 sec.sup. -1. The gas to slurry volume ratio should also be controlled to assure that the flow regime does not shift from homogeneous flow to non-homogeneous flow. Stable operations have been observed with a maximum gas holdup as high as 0.72.

Measuring Intracranial Pressure And Volume Noninvasively

NASA Technical Reports Server (NTRS)

Cantrell, John H.; Yost, William T.

1994-01-01

Ultrasonic technique eliminates need to drill into brain cavity. Intracranial dynamics instrument probes cranium ultrasonically to obtain data for determination of intracranial pressure (ICP) and pressure-volume index (PVI). Instrument determines sensitivity of skull to changes in pressure and by use of mechanical device to exert external calibrated pressure on skull. By monitoring volume of blood flowing into jugular vein, one determines change of volume of blood in cranial system. By measuring response of skull to increasing pressure (where pressure increased by tilting patient known amount) and by using cranial blood pressure, one determines intial pressure in cerebrospinal fluid. Once PVI determined, ICP determined.

A novel miniature dynamic microfluidic cell culture platform using electro-osmosis diode pumping.

PubMed

Chang, Jen-Yung; Wang, Shuo; Allen, Jeffrey S; Lee, Seong Hyuk; Chang, Suk Tai; Choi, Young-Ki; Friedrich, Craig; Choi, Chang Kyoung

2014-07-01

An electro-osmosis (EOS) diode pumping platform capable of culturing cells in fluidic cellular micro-environments particularly at low volume flow rates has been developed. Diode pumps have been shown to be a viable alternative to mechanically driven pumps. Typically electrokinetic micro-pumps were limited to low-concentration solutions (≤10 mM). In our approach, surface mount diodes were embedded along the sidewalls of a microchannel to rectify externally applied alternating current into pulsed direct current power across the diodes in order to generate EOS flows. This approach has for the first time generated flows at ultra-low flow rates (from 2.0 nl/s to 12.3 nl/s) in aqueous solutions with concentrations greater than 100 mM. The range of flow was generated by changing the electric field strength applied to the diodes from 0.5 Vpp/cm to 10 Vpp/cm. Embedding an additional diode on the upper surface of the enclosed microchannel increased flow rates further. We characterized the diode pump-driven fluidics in terms of intensities and frequencies of electric inputs, pH values of solutions, and solution types. As part of this study, we found that the growth of A549 human lung cancer cells was positively affected in the microfluidic diode pumping system. Though the chemical reaction compromised the fluidic control overtime, the system could be maintained fully functional over a long time if the solution was changed every hour. In conclusion, the advantage of miniature size and ability to accurately control fluids at ultra-low volume flow rates can make this diode pumping system attractive to lab-on-a-chip applications and biomedical engineering in vitro studies.

A novel miniature dynamic microfluidic cell culture platform using electro-osmosis diode pumping

PubMed Central

Chang, Jen-Yung; Wang, Shuo; Allen, Jeffrey S.; Lee, Seong Hyuk; Chang, Suk Tai; Choi, Young-Ki; Friedrich, Craig; Choi, Chang Kyoung

2014-01-01

An electro-osmosis (EOS) diode pumping platform capable of culturing cells in fluidic cellular micro-environments particularly at low volume flow rates has been developed. Diode pumps have been shown to be a viable alternative to mechanically driven pumps. Typically electrokinetic micro-pumps were limited to low-concentration solutions (≤10 mM). In our approach, surface mount diodes were embedded along the sidewalls of a microchannel to rectify externally applied alternating current into pulsed direct current power across the diodes in order to generate EOS flows. This approach has for the first time generated flows at ultra-low flow rates (from 2.0 nl/s to 12.3 nl/s) in aqueous solutions with concentrations greater than 100 mM. The range of flow was generated by changing the electric field strength applied to the diodes from 0.5 Vpp/cm to 10 Vpp/cm. Embedding an additional diode on the upper surface of the enclosed microchannel increased flow rates further. We characterized the diode pump-driven fluidics in terms of intensities and frequencies of electric inputs, pH values of solutions, and solution types. As part of this study, we found that the growth of A549 human lung cancer cells was positively affected in the microfluidic diode pumping system. Though the chemical reaction compromised the fluidic control overtime, the system could be maintained fully functional over a long time if the solution was changed every hour. In conclusion, the advantage of miniature size and ability to accurately control fluids at ultra-low volume flow rates can make this diode pumping system attractive to lab-on-a-chip applications and biomedical engineering in vitro studies. PMID:25379101

Estimating Preferential Flow in Karstic Aquifers Using Statistical Mixed Models

PubMed Central

Anaya, Angel A.; Padilla, Ingrid; Macchiavelli, Raul; Vesper, Dorothy J.; Meeker, John D.; Alshawabkeh, Akram N.

2013-01-01

Karst aquifers are highly productive groundwater systems often associated with conduit flow. These systems can be highly vulnerable to contamination, resulting in a high potential for contaminant exposure to humans and ecosystems. This work develops statistical models to spatially characterize flow and transport patterns in karstified limestone and determines the effect of aquifer flow rates on these patterns. A laboratory-scale Geo-HydroBed model is used to simulate flow and transport processes in a karstic limestone unit. The model consists of stainless-steel tanks containing a karstified limestone block collected from a karst aquifer formation in northern Puerto Rico. Experimental work involves making a series of flow and tracer injections, while monitoring hydraulic and tracer response spatially and temporally. Statistical mixed models are applied to hydraulic data to determine likely pathways of preferential flow in the limestone units. The models indicate a highly heterogeneous system with dominant, flow-dependent preferential flow regions. Results indicate that regions of preferential flow tend to expand at higher groundwater flow rates, suggesting a greater volume of the system being flushed by flowing water at higher rates. Spatial and temporal distribution of tracer concentrations indicates the presence of conduit-like and diffuse flow transport in the system, supporting the notion of both combined transport mechanisms in the limestone unit. The temporal response of tracer concentrations at different locations in the model coincide with, and confirms the preferential flow distribution generated with the statistical mixed models used in the study. PMID:23802921

Estimating preferential flow in karstic aquifers using statistical mixed models.

PubMed

Anaya, Angel A; Padilla, Ingrid; Macchiavelli, Raul; Vesper, Dorothy J; Meeker, John D; Alshawabkeh, Akram N

2014-01-01

Karst aquifers are highly productive groundwater systems often associated with conduit flow. These systems can be highly vulnerable to contamination, resulting in a high potential for contaminant exposure to humans and ecosystems. This work develops statistical models to spatially characterize flow and transport patterns in karstified limestone and determines the effect of aquifer flow rates on these patterns. A laboratory-scale Geo-HydroBed model is used to simulate flow and transport processes in a karstic limestone unit. The model consists of stainless steel tanks containing a karstified limestone block collected from a karst aquifer formation in northern Puerto Rico. Experimental work involves making a series of flow and tracer injections, while monitoring hydraulic and tracer response spatially and temporally. Statistical mixed models (SMMs) are applied to hydraulic data to determine likely pathways of preferential flow in the limestone units. The models indicate a highly heterogeneous system with dominant, flow-dependent preferential flow regions. Results indicate that regions of preferential flow tend to expand at higher groundwater flow rates, suggesting a greater volume of the system being flushed by flowing water at higher rates. Spatial and temporal distribution of tracer concentrations indicates the presence of conduit-like and diffuse flow transport in the system, supporting the notion of both combined transport mechanisms in the limestone unit. The temporal response of tracer concentrations at different locations in the model coincide with, and confirms the preferential flow distribution generated with the SMMs used in the study. © 2013, National Ground Water Association.

Improving hemodynamics of cardiovascular system under a novel intraventricular assist device support via modeling and simulations.

PubMed

Zhu, Shidong; Luo, Lin; Yang, Bibo; Li, Xinghui; Wang, Xiaohao

2017-12-01

Ventricular assist devices (LVADs) are increasingly recognized for supporting blood circulation in heart failure patients who are non-transplant eligible. Because of its volume, the traditional pulsatile device is not easy to implant intracorporeally. Continuous flow LVADs (CF-LVADs) reduce arterial pulsatility and only offer continuous flow, which is different from physiological flow, and may cause long-term complications in the cardiovascular system. The aim of this study was to design a new pulsatile assist device that overcomes this disadvantage, and to test this device in the cardiovascular system. Firstly, the input and output characteristics of the new device were tested in a simple cardiovascular mock system. A detailed mathematical model was established by fitting the experimental data. Secondly, the model was tested in four pathological cases, and was simulated and coupled with a fifth-order cardiovascular system and a new device model using Matlab software. Using assistance of the new device, we demonstrated that the left ventricle pressure, aortic pressure, and aortic flow of heart failure patients improved to the levels of a healthy individual. Especially, in state IV level heart failure patients, the systolic blood pressure increased from 81.34 mmHg to 132.1 mmHg, whereas the diastolic blood pressure increased from 54.28 mmHg to 78.7 mmHg. Cardiac output increased from 3.21 L/min to 5.16 L/min. The newly-developed assist device not only provided a physiological flow that was similar to healthy individuals, but also effectively improved the ability of the pathological ventricular volume. Finally, the effects of the new device on other hemodynamic parameters are discussed.

[A simple model for describing pressure-volume curves in free balloon dilatation with reference the dynamics of inflation hydraulic aspects].

PubMed

Bloss, P; Werner, C

2000-06-01

We propose a simple model to describe pressure-time and pressure-volume curves for the free balloon (balloon in air) of balloon catheters, taking into account the dynamics of the inflation device. On the basis of our investigations of the flow rate-dependence of characteristic parameters of the pressure-time curves, the appropriateness of this simple model is demonstrated using a representative example. Basic considerations lead to the following assumptions: (1) the flow within the shaft of the catheter is laminar, and (ii) the volume decrease of the liquid used for inflation due to pressurization can be neglected if the liquid is carefully degassed prior to inflation, and if the total volume of the liquid in the system is less than 2 ml. Taking into account the dynamics of the inflation device used for pumping the liquid into the proximal end of the shaft during inflation, the inflation process can be subdivided into the following three phases: initial phase, filling phase and dilatation phase. For these three phases, the transformation of the time into the volume coordinates is given. On the basis of our model, the following parameters of the balloon catheter can be determined from a measured pressure-time curve: (1) the resistance to flow of the liquid through the shaft of the catheter and the resulting pressure drop across the shaft, (2) the residual volume and residual pressure of the balloon, and (3) the volume compliance of the balloon catheter with and without the inflation device.

Geohydrology, aqueous geochemistry, and thermal regime of the Soda Lakes and Upsal Hogback geothermal systems, Churchill County, Nevada

USGS Publications Warehouse

Olmsted, F.H.; Welch, A.H.; Van Denburgh, A.S.; Ingebritsen, S.E.

1984-01-01

A flow-routing model of the upper Schoharie Creek basin, New York, was developed and used to simulate high flows at the inlet of the Blenheim-Gilboa Reservoir. The flows from Schoharie Creek at Prattsville, the primary source of flow data in the basin, and tributary flows from the six minor basins downstream, are combined and routed along the 9.7 mile reach of the Schoharie Creek between Prattsville and the reservoir inlet. Data from five historic floods were used for model calibration and four for verification. The accuracy of the model as measured by the difference between simulated and observed total flow volumes, is within 14 percent. Results indicate that inflows to the Blenheim-Gilboa Reservoir can be predicted approximately 2 hours in advance. One of the historical floods was chosen for additional model testing to assess a hypothetical real-time model application. Total flow-volume errors ranged from 30.2 percent to -9.2 percent. Alternative methods of obtaining hydrologic data for model input are presented for use in the event that standard forms of hydrologic data are unavailable. (USGS)

Laser Light Scattering Diagnostic for Measurement of Flow Velocity in Vicinity of Propagating Shock Waves

NASA Technical Reports Server (NTRS)

Seasholtz, Richard G.; Buggele, Alvin E.

2002-01-01

A laser light scattering diagnostic for measurement of dynamic flow velocity at a point is described. The instrument is being developed for use in the study of propagating shock waves and detonation waves in pulse detonation engines under development at the NASA Glenn Research Center (GRC). The approach uses a Fabry-Perot interferometer to measure the Doppler shift of laser light scattered from small (submicron) particles in the flow. The high-speed detection system required to resolve the transient response as a shock wave crosses the probe volume uses fast response photodetectors, and a PC based data acquisition system. Preliminary results of measurements made in the GRC Mach 4, 10 by 25 cm supersonic wind tunnel are presented. Spontaneous condensation of water vapor in the flow is used as seed. The tunnel is supplied with continuous air flow at up to 45 psia and the flow is exhausted into the GRC laboratory-wide altitude exhaust system at pressures down to 0.3 psia.

Mixing and segregation of microspheres in microchannel flows of mono- and bidispersed suspensions

NASA Astrophysics Data System (ADS)

Gao, C.; Xu, B.; Gilchrist, J. F.

2009-03-01

We investigate the mixing and segregation of mono- and bidispersed microsphere suspensions in microchannel flows. These flows are common in biological microelectromechanical systems (BioMEMS) applications handling blood or suspensions of DNA. Suspension transport in pressure driven flows is significantly hindered by shear-induced migration, where particles migrate away from the walls and are focused in the center due to multibody hydrodynamic interactions. The microchannels used in this study have geometries that induce chaotic advection in Newtonian fluids. Our results show that mixing in straight, herringbone and staggered herringbone channels depends strongly on volume fraction. Due to this complex interplay of advection and shear-induced migration, a staggered herringbone channel that typically results in chaotic mixing is not always effective for dispersing particles. The maximum degree of segregation is observed in a straight channel once the maximum packing fraction is reached at channel center. We modify a one-dimensional suspension balance model [R. Miller and J. Morris, J. Non-Newtonian Fluid Mech. 135, 149 (2006)] to describe the behavior at the center of the straight channel. The degree of mixing is then calculated as a function of bulk volume fraction, predicting the volume fraction that results in the maximum degree of segregation. In bidispersed suspension flow, it is shown that mixing of the larger species is enhanced in straight and staggered herringbone channels while segregation is enhanced at moderate volume fractions in herringbone channels. This suggests mixing and separations can be tailored by adjusting both the suspension properties and the channel geometry.

Assessment of Factors Related to Auto-PEEP.

PubMed

Natalini, Giuseppe; Tuzzo, Daniele; Rosano, Antonio; Testa, Marco; Grazioli, Michele; Pennestrì, Vincenzo; Amodeo, Guido; Marsilia, Paolo F; Tinnirello, Andrea; Berruto, Francesco; Fiorillo, Marialinda; Filippini, Matteo; Peratoner, Alberto; Minelli, Cosetta; Bernardini, Achille

2016-02-01

Previous physiological studies have identified factors that are involved in auto-PEEP generation. In our study, we examined how much auto-PEEP is generated from factors that are involved in its development. One hundred eighty-six subjects undergoing controlled mechanical ventilation with persistent expiratory flow at the beginning of each inspiration were enrolled in the study. Volume-controlled continuous mandatory ventilation with PEEP of 0 cm H2O was applied while maintaining the ventilator setting as chosen by the attending physician. End-expiratory and end-inspiratory airway occlusion maneuvers were performed to calculate respiratory mechanics, and tidal flow limitation was assessed by a maneuver of manual compression of the abdomen. The variable with the strongest effect on auto-PEEP was flow limitation, which was associated with an increase of 2.4 cm H2O in auto-PEEP values. Moreover, auto-PEEP values were directly related to resistance of the respiratory system and body mass index and inversely related to expiratory time/time constant. Variables that were associated with the breathing pattern (tidal volume, frequency minute ventilation, and expiratory time) did not show any relationship with auto-PEEP values. The risk of auto-PEEP ≥5 cm H2O was increased by flow limitation (adjusted odds ratio 17; 95% CI: 6-56.2), expiratory time/time constant ratio <1.85 (12.6; 4.7-39.6), respiratory system resistance >15 cm H2O/L s (3; 1.3-6.9), age >65 y (2.8; 1.2-6.5), and body mass index >26 kg/m(2) (2.6; 1.1-6.1). Flow limitation, expiratory time/time constant, resistance of the respiratory system, and obesity are the most important variables that affect auto-PEEP values. Frequency expiratory time, tidal volume, and minute ventilation were not independently associated with auto-PEEP. Therapeutic strategies aimed at reducing auto-PEEP and its adverse effects should be primarily oriented to the variables that mainly affect auto-PEEP values. Copyright © 2016 by Daedalus Enterprises.

Communication Patterns in the Perioperative Environment During Epic Electronic Health Record System Implementation.

PubMed

Friend, Tynan H; Jennings, Samantha J; Levine, Wilton C

2017-02-01

In April 2016, Massachusetts General Hospital (MGH) went live with the Epic electronic health records (EHR) system, replacing a variety of EHRs that previously existed in different departments throughout the hospital. At the time of implementation, the Vocera® Badge Communication System, a wireless hands-free communication device distributed to perioperative team members, had increased perioperative communication flow and efficiency. As a quality improvement effort to better understand communication patterns during an EHR go-live, we monitored our Vocera call volume and user volume before, during and after our go-live. We noticed that call volume and user volume significantly increased during our immediate go-live period and quickly returned to baseline levels. We also noticed that call volume increased during periods of unplanned EHR downtime long after our immediate go-live period. When planning the implementation of a new EHR, leadership must plan for and support this critical communication need at the time of the go-live and must also be aware of these needs during unplanned downtime.

System and process for capture of acid gasses at elevated pressure from gaseous process streams

DOEpatents

Heldebrant, David J.; Koech, Phillip K.; Linehan, John C.; Rainbolt, James E.; Bearden, Mark D.; Zheng, Feng

2016-09-06

A system, method, and material that enables the pressure-activated reversible chemical capture of acid gasses such as CO.sub.2 from gas volumes such as streams, flows or any other volume. Once the acid gas is chemically captured, the resulting product typically a zwitterionic salt, can be subjected to a reduced pressure whereupon the resulting product will release the captures acid gas and the capture material will be regenerated. The invention includes this process as well as the materials and systems for carrying out and enabling this process.

Multiparametric Flow System for the Automated Determination of Sodium, Potassium, Calcium, and Magnesium in Large-Volume Parenteral Solutions and Concentrated Hemodialysis Solutions

PubMed Central

Pistón, Mariela; Dol, Isabel

2006-01-01

A multiparametric flow system based on multicommutation and binary sampling has been designed for the automated determination of sodium, potassium, calcium, and magnesium in large-volume parenteral solutions and hemodialysis concentrated solutions. The goal was to obtain a computer-controlled system capable of determining the four metals without extensive modifications. The system involved the use of five solenoid valves under software control, allowing the establishment of the appropriate flow conditions for each analyte, that is, sample size, dilution, reagent addition, and so forth. Detection was carried out by either flame atomic emission spectrometry (sodium, potassium) or flame atomic absorption spectrometry (calcium, magnesium). The influence of several operating parameters was studied. Validation was carried out by analyzing artificial samples. Figures of merit obtained include linearity, accuracy, precision, and sampling frequency. Linearity was satisfactory: sodium, r 2 >0.999 ( 0.5 – 3.5 g/L), potassium, r 2 >0.996 (50–150 mg/L), calcium, r 2 >0.999 (30–120 mg/L), and magnesium, r 2 >0.999 (20–40 mg/L). Precision ( s r , %, n=5 ) was better than 2.1 %, and accuracy (evaluated through recovery assays) was in the range of 99.8 %– 101.0 % (sodium), 100.8 – 102.5 % (potassium), 97.3 %– 101.3 % (calcium), and 97.1 %– 99.8 % (magnesium). Sampling frequencies ( h −1 ) were 70 (sodium), 75 (potassium), 70 (calcium), and 58 (magnesium). According to the results obtained, the use of an automated multiparametric system based on multicommutation offers several advantages for the quality control of large-volume parenteral solutions and hemodialysis concentrated solutions. PMID:17671619

Effect of ambient pressure variation on closed loop gas system for India based Neutrino Observatory (INO)

NASA Astrophysics Data System (ADS)

Satyanarayana, B.; Majumder, G.; Mondal, N. K.; Kalmani, S. D.; Shinde, R. R.; Joshi, A.

2014-10-01

Pilot unit of a closed loop gas mixing and distribution system for the INO project was designed and is being operated with 1.8meters × 1.9meters RPCs for about two years. A number of studies on controlling the flow and optimisation of the gas mixture through the RPC stack were carried out during this period. The gas system essentially measures and attempts to maintain absolute pressure inside the RPC gas volume. During typical Mumbai monsoon seasons, the barometric pressure changes rather rapidly, due to which the gas system fails to maintain the set differential pressure between the ambience and the RPC gas volume. As the safety bubblers on the RPC gas input lines are set to work on fixed pressure differentials, the ambient pressure changes lead to either venting out and thus wasting gas through safety bubblers or over pressuring the RPCs gas volume and thus degrading its performance. The above problem also leads to gas mixture contamination through minute leaks in gas gap. The problem stated above was solved by including the ambient barometric pressure as an input parameter in the closed loop. Using this, it is now possible to maintain any set differential pressure between the ambience and RPC gas volumes between 0 to 20mm of water column, thus always ensuring a positive pressure inside the RPC gas volume with respect to the ambience. This has resulted in improved performance of the gas system by maintaining the constant gas flow and reducing the gas toping up frequency. In this paper, we will highlight the design features and improvements of the closed loop gas system. We will present some of the performance studies and considerations for scaling up the system to be used with the engineering module and then followed by Iron Calorimeter detector (ICAL), which is designed to deploy about 30,000 RPCs of 1.8meters × 1.9 meters in area.

Uranium droplet core nuclear rocket

NASA Technical Reports Server (NTRS)

Anghaie, Samim

1991-01-01

Uranium droplet nuclear rocket is conceptually designed to utilize the broad temperature range ofthe liquid phase of metallic uranium in droplet configuration which maximizes the energy transfer area per unit fuel volume. In a baseline system dissociated hydrogen at 100 bar is heated to 6000 K, providing 2000 second of Isp. Fission fragments and intense radian field enhance the dissociation of molecular hydrogen beyond the equilibrium thermodynamic level. Uranium droplets in the core are confined and separated by an axisymmetric vortex flow generated by high velocity tangential injection of hydrogen in the mid-core regions. Droplet uranium flow to the core is controlled and adjusted by a twin flow nozzle injection system.

Optimum aerobic volume control based on continuous in-line oxygen uptake monitoring.

PubMed

Svardal, K; Lindtner, S; Winkler, S

2003-01-01

Dynamic adaptation of the aerated volume to changing load conditions is essential to maximise the nitrogen removal performance and to minimise energy consumption. A control strategy is presented which provides optimum aerobic volume control (OAV-control concept) based on continuous in-line oxygen uptake monitoring. For ammonium concentrations below 1 mg/l the oxygen uptake rate shows a strong and almost linear dependency on the ammonium concentration. Therefore, the oxygen uptake rate is an ideal indicator for the nitrification performance in activated sludge systems. The OAV-control concept provides dynamic variation of the minimum aerobic volume required for complete nitrification and therefore maximises the denitrification performance. In-line oxygen uptake monitoring is carried out by controlling the oxygen concentration in a continuous aerated zone of the aeration tank and measuring the total air flow to the aeration tank. The total air flow to the aeration tank is directly proportional to the current oxygen uptake rate and can therefore be used as an indicator for the required aerobic volume. The instrumentation requirements for installation of the OAV-control are relatively low, oxygen sensors in the aeration tank and an on-line air flow measurement are needed. This enables individual control of aeration tanks operated in parallel at low investment costs. The OAV-control concept is installed at the WWTP Linz-Asten (1 Mio PE) and shows very good results. Full scale results are presented.

A combined volume-of-fluid method and low-Mach-number approach for DNS of evaporating droplets in turbulence

NASA Astrophysics Data System (ADS)

Dodd, Michael; Ferrante, Antonino

2017-11-01

Our objective is to perform DNS of finite-size droplets that are evaporating in isotropic turbulence. This requires fully resolving the process of momentum, heat, and mass transfer between the droplets and surrounding gas. We developed a combined volume-of-fluid (VOF) method and low-Mach-number approach to simulate this flow. The two main novelties of the method are: (i) the VOF algorithm captures the motion of the liquid gas interface in the presence of mass transfer due to evaporation and condensation without requiring a projection step for the liquid velocity, and (ii) the low-Mach-number approach allows for local volume changes caused by phase change while the total volume of the liquid-gas system is constant. The method is verified against an analytical solution for a Stefan flow problem, and the D2 law is verified for a single droplet in quiescent gas. We also demonstrate the schemes robustness when performing DNS of an evaporating droplet in forced isotropic turbulence.

Continuous on-line measurements of respiratory system, lung and chest wall mechanics during mechanic ventilation.

PubMed

Kárason, S; Søndergaard, S; Lundin, S; Stenqvist, O

2001-08-01

We present a concept of on-line, manoeuvre-free monitoring of respiratory mechanics during dynamic conditions, displaying calculated alveolar pressure/volume curves continuously and separating lung and chest wall mechanics. Prospective observational study. Intensive care unit of a university hospital. Ten ventilator-treated patients with acute lung injury. Different positive end-expiratory pressure (PEEP) and tidal volumes, low flow inflation. Previously validated methods were used to present a single-value dynostatic compliance for the whole breath and a dynostatic volume-dependent initial, middle and final compliance within the breath. A high individual variation of respiratory mechanics was observed. Reproducibility of repeated measurements was satisfactory (coefficients of variations for dynostatic volume-dependent compliance: < or =9.2% for total respiratory system, < or =18% for lung). Volume-dependent compliance showed a statistically significant pattern of successively decreasing compliance from the initial segment through the middle and final parts within each breath at all respiratory settings. This pattern became more prominent with increasing PEEP and tidal volume, indicating a greater distension of alveoli. No lower inflection point (LIP) was seen in patients with respiratory rate 20/min and PEEP at 4 cmH2O. A trial with low flow inflation in four of the patients showed formation of a LIP in three of them and an upper inflection in one. The monitoring concept revealed a constant pattern of successively decreasing compliance within each breath, which became more prominent with increasing PEEP and tidal volume. The monitoring concept offers a simple and reliable method of monitoring respiratory mechanics during ongoing ventilator treatment.

Influence of liquid-volume and airflow rates on spray application quality and homogeneity in super-intensive olive tree canopies.

PubMed

Miranda-Fuentes, Antonio; Rodríguez-Lizana, Antonio; Gil, Emilio; Agüera-Vega, J; Gil-Ribes, Jesús A

2015-12-15

Olive is a key crop in Europe, especially in countries around the Mediterranean Basin. Optimising the parameters of a spray is essential for sustainable pesticide use, especially in high-input systems, such as the super-intensive hedgerow system. Parameters may be optimised by adjusting the applied volume and airflow rate of sprays, in addition to the liquid to air proportion and the relationship between air velocity and airflow rate. Two spray experiments using a commercial airblast sprayer were conducted in a super-intensive orchard to study how varying the liquid volume rate (testing volumes of 182, 619, and 1603 l ha(-1)) and volumetric airflow rate (with flow rates of 11.93, 8.90, and 6.15 m(3) s(-1)) influences the coverage parameters and the amount and distribution of deposits in different zones of the canopy.. Our results showed that an increase in the application volume raised the mean deposit and percentage coverage, but decreased the application efficiency, spray penetration, and deposit homogeneity. Furthermore, we found that the volumetric airflow rate had a lower influence on the studied parameters than the liquid volume; however, an increase in the airflow rate improved the application efficiency and homogeneity to a certain threshold, after which the spray quality decreased. This decrease was observed in the high-flow treatment. Our results demonstrate that intermediate liquid volume rates and volumetric airflow rates are required for the optimal spraying of pesticides on super-intensive olive crops, and would reduce current pollution levels. Copyright © 2015 Elsevier B.V. All rights reserved.

Numerical solution of the two-dimensional time-dependent incompressible Euler equations

NASA Technical Reports Server (NTRS)

Whitfield, David L.; Taylor, Lafayette K.

1994-01-01

A numerical method is presented for solving the artificial compressibility form of the 2D time-dependent incompressible Euler equations. The approach is based on using an approximate Riemann solver for the cell face numerical flux of a finite volume discretization. Characteristic variable boundary conditions are developed and presented for all boundaries and in-flow out-flow situations. The system of algebraic equations is solved using the discretized Newton-relaxation (DNR) implicit method. Numerical results are presented for both steady and unsteady flow.

Shuttle filter study. Volume 3: Appendix

NASA Technical Reports Server (NTRS)

1974-01-01

Test data obtained from flow resistance and contaminant tolerance tests on the various porous media evaluated in the different fluids are presented in both graphical and tabular forms. Test procedures for both flow resistance and contaminant tolerance testing are presented, and the development of a system for continuously adding contaminant at a predetermined rate to a flowing fluid stream is described. Also included is a section describing the development effort of the self-indexing filter. This concept was adapted during this program for various shuttle applications.

Distribution of extravascular fluid volumes in isolated perfused lungs measured with H215O.

PubMed Central

Jones, T; Jones, H A; Rhodes, C G; Buckingham, P D; Hughes, J M

1976-01-01

The distributions per unit volume of extravascular water (EVLW), blood volume, and blood flow were measured in isolated perfused vertical dog lungs. A steady-state tracer technique was employed using oxygen-15, carbon-11, and nitrogen-13 isotopes and external scintillation counting of the 511-KeV annihilation radiation common to all three radionuclides. EVLW, and blood volume and flow increased from apex to base in all preparations, but the gradient of increasing flow exceeded that for blood and EVLW volumes. The regional distributions of EVLW and blood volume were almost identical. With increasing edema, lower-zone EVLW increased slightly relative to that in the upper zone. There was no change in the distribution of blood volume or flow until gross edema (100% wt gain) occurred when lower zone values were reduced. In four lungs the distribution of EVLW was compared with wet-to-dry ratios from lung biopsies taken immediately afterwards. Whereas the isotopically measured EVLW increased from apex to base, the wet-to-dry weight ratios remained essentially uniform. We concluded that isotopic methods measure only an "exchangeable" water pool whose volume is dependent on regional blood flow and capillary recruitment. Second, the isolated perfused lung can accommodate up to 60% wt gain without much change in the regional distribution of EVLW, volume, or flow. PMID:765354

Emergent Chemical Behavior in Variable-Volume Protocells

PubMed Central

Shirt-Ediss, Ben; Solé, Ricard V.; Ruiz-Mirazo, Kepa

2015-01-01

Artificial protocellular compartments and lipid vesicles have been used as model systems to understand the origins and requirements for early cells, as well as to design encapsulated reactors for biotechnology. One prominent feature of vesicles is the semi-permeable nature of their membranes, able to support passive diffusion of individual solute species into/out of the compartment, in addition to an osmotic water flow in the opposite direction to the net solute concentration gradient. Crucially, this water flow affects the internal aqueous volume of the vesicle in response to osmotic imbalances, in particular those created by ongoing reactions within the system. In this theoretical study, we pay attention to this often overlooked aspect and show, via the use of a simple semi-spatial vesicle reactor model, that a changing solvent volume introduces interesting non-linearities into an encapsulated chemistry. Focusing on bistability, we demonstrate how a changing volume compartment can degenerate existing bistable reactions, but also promote emergent bistability from very simple reactions, which are not bistable in bulk conditions. One particularly remarkable effect is that two or more chemically-independent reactions, with mutually exclusive reaction kinetics, are able to couple their dynamics through the variation of solvent volume inside the vesicle. Our results suggest that other chemical innovations should be expected when more realistic and active properties of protocellular compartments are taken into account. PMID:25590570

DOE Office of Scientific and Technical Information (OSTI.GOV)

Willis-Richards, J.; Watanable, K.; Yamaguchi, T.

A set of models of HDR systems is presented which attempts to explain the formation and operation of HDR systems using only the in-situ properties of the fractured rock mass, the earth stress field, the engineering intervention applied by way of stimulation and the relative positions and pressures of the well(s). A statistical and rock mechanics description of fractures in low permeability rocks provides the basis for modeling of stimulation, circulation and water loss in HDR systems. The model uses a large number of parameters, chiefly simple directly measurable quantities, describing the rock mass and fracture system. The effect ofmore » stimulation (raised fluid pressure allowing slip) on fracture apertures is calculated, and the volume of rock affected per volume of fluid pumped estimated. The total rock volume affected by stimulation is equated with the rock volume containing the associated AE (microseismicity). The aperture and compliance properties of the stimulated fractures are used to estimate impedance and flow within the reservoir. Fluid loss from the boundary of the stimulated volume is treated using radial leak-off with pressure-dependent permeability.« less

Impact of the column hardware volume on resolution in very high pressure liquid chromatography non-invasive investigations.

PubMed

Gritti, Fabrice; McDonald, Thomas; Gilar, Martin

2015-11-13

The impact of the column hardware volume (≃ 1.7 μL) on the optimum reduced plate heights of a series of short 2.1 mm × 50 mm columns (hold-up volume ≃ 80-90 μL) packed with 1.8 μm HSS-T3, 1.7 μm BEH-C18, 1.7 μm CSH-C18, 1.6 μm CORTECS-C18+, and 1.7 μm BEH-C4 particles was investigated. A rapid and non-invasive method based on the reduction of the system dispersion (to only 0.15 μL(2)) of an I-class Acquity system and on the corrected plate heights (for system dispersion) of five weakly retained n-alkanophenones in RPLC was proposed. Evidence for sample dispersion through the column hardware volume was also revealed from the experimental plot of the peak capacities for smooth linear gradients versus the corrected efficiency of a weakly retained alkanophenone (isocratic runs). The plot is built for a constant gradient steepness irrespective of the applied flow rates (0.01-0.30 mL/min) and column lengths (2, 3, 5, and 10 cm). The volume variance caused by column endfittings and frits was estimated in between 0.1 and 0.7 μL(2) depending on the applied flow rate. After correction for system and hardware dispersion, the minimum reduced plate heights of short (5 cm) and narrow-bore (2.1mm i.d.) beds packed with sub-2 μm fully and superficially porous particles were found close to 1.5 and 0.7, respectively, instead of the classical h values of 2.0 and 1.4 for the whole column assembly. Copyright © 2015 Elsevier B.V. All rights reserved.

SyPRID sampler: A large-volume, high-resolution, autonomous, deep-ocean precision plankton sampling system

NASA Astrophysics Data System (ADS)

Billings, Andrew; Kaiser, Carl; Young, Craig M.; Hiebert, Laurel S.; Cole, Eli; Wagner, Jamie K. S.; Van Dover, Cindy Lee

2017-03-01

The current standard for large-volume (thousands of cubic meters) zooplankton sampling in the deep sea is the MOCNESS, a system of multiple opening-closing nets, typically lowered to within 50 m of the seabed and towed obliquely to the surface to obtain low-spatial-resolution samples that integrate across 10 s of meters of water depth. The SyPRID (Sentry Precision Robotic Impeller Driven) sampler is an innovative, deep-rated (6000 m) plankton sampler that partners with the Sentry Autonomous Underwater Vehicle (AUV) to obtain paired, large-volume plankton samples at specified depths and survey lines to within 1.5 m of the seabed and with simultaneous collection of sensor data. SyPRID uses a perforated Ultra-High-Molecular-Weight (UHMW) plastic tube to support a fine mesh net within an outer carbon composite tube (tube-within-a-tube design), with an axial flow pump located aft of the capture filter. The pump facilitates flow through the system and reduces or possibly eliminates the bow wave at the mouth opening. The cod end, a hollow truncated cone, is also made of UHMW plastic and includes a collection volume designed to provide an area where zooplankton can collect, out of the high flow region. SyPRID attaches as a saddle-pack to the Sentry vehicle. Sentry itself is configured with a flight control system that enables autonomous survey paths to low altitudes. In its verification deployment at the Blake Ridge Seep (2160 m) on the US Atlantic Margin, SyPRID was operated for 6 h at an altitude of 5 m. It recovered plankton samples, including delicate living larvae, from the near-bottom stratum that is seldom sampled by a typical MOCNESS tow. The prototype SyPRID and its next generations will enable studies of plankton or other particulate distributions associated with localized physico-chemical strata in the water column or above patchy habitats on the seafloor.

Insect contamination protection for laminar flow surfaces

NASA Technical Reports Server (NTRS)

Croom, Cynthia C.; Holmes, Bruce J.

1986-01-01

The ability of modern aircraft surfaces to achieve laminar flow was well-accepted in recent years. Obtaining the maximum benefit of laminar flow for aircraft drag reduction requires maintaining minimum leading-edge contamination. Previously proposed insect contamination prevention methods have proved impractical due to cost, weight, or inconvenience. Past work has shown that insects will not adhere to water-wetted surfaces, but the large volumes of water required for protection rendered such a system impractical. The results of a flight experiment conducted by NASA to evaluate the performance of a porous leading-edge fluid discharge ice protection system operated as an insect contamination protections system are presented. In addition, these flights explored the environmental and atmospheric conditions most suitable for insect accumulation.

Optoelectronic system for the determination of blood volume in pneumatic heart assist devices.

PubMed

Konieczny, Grzegorz; Pustelny, Tadeusz; Setkiewicz, Maciej; Gawlikowski, Maciej

2015-12-10

The following article describes the concept of optical measurement of blood volume in ventricular assist devices (VAD's) of the pulsatile type. The paper presents the current state of art in blood volume measurements of such devices and introduces a newly developed solution in the optic domain. The objective of the research is to overcome the disadvantages of the previously developed acoustic method-the requirement of additional sensor chamber. The idea of a compact measurement system has been introduced, followed by laboratory measurements. Static tests of the system have been presented, followed by dynamic measurements on a physical model of the human ventricular system. The results involving the measurements of blood chamber volume acquired by means of an optical system have been compared with the results acquired by means of the Transonic T410 ultrasound flow rate sensor (11PLX transducer, uncertainty ±5 %). Preliminary dynamic measurements conducted on the physical model of the human cardiovascular system show that the proposed optical measurement system may be used to measure the transient blood chamber volumes of pulsatile VAD's with the uncertainties (standard mean deviation) lower than 10 %. The results show that the noninvasive measurements of the temporary blood chamber volume in the POLVAD prosthesis with the use of the developed optical system allows us to carry out accurate static and dynamic measurements.

A study of the rheology and micro-structure of dumbbells in shear geometries

NASA Astrophysics Data System (ADS)

Mandal, Sandip; Khakhar, D. V.

2018-01-01

We study the flow of frictional, inelastic dumbbells made of two fused spheres of different aspect ratios down a rough inclined plane and in a simple shear cell, using discrete element simulations. At a fixed inclination angle, the mean velocity decreases, and the volume fraction increases significantly with increasing aspect ratio in the chute flow. At a fixed solid fraction, the shear stress and pressure decrease significantly with increasing aspect ratio in the shear cell flow. The micro-structure of the flow is characterized. The translational diffusion coefficient in the normal direction to the flow is found to scale as Dy y=b γ ˙ d2, independent of aspect ratio, where b is a constant, γ ˙ is the shear rate, and d is the diameter of the constituent spheres of the dumbbells. The effective friction coefficient (μ, the ratio of shear stress to pressure) increases by 30%-35% on increasing the aspect ratio λ, from 1.0 to 1.7, for a fixed inertial number I. The volume fraction (ϕ) also increases significantly with increasing aspect ratio, especially at high inertial numbers. The effective friction coefficient and volume fraction are found to follow simple scalings of the form μ = μ(I, λ) and ϕ = ϕ(I, λ) for all the data from both systems, and the results are in reasonable agreement with kinetic theory predictions at low I. The computational results are in reasonable agreement with the experimental data for flow in a rotating cylinder.

Effect of subsurface heterogeneity on free-product recovery from unconfined aquifers

NASA Astrophysics Data System (ADS)

Kaluarachchi, Jagath J.

1996-03-01

Free-product record system designs for light-hydrocarbon-contaminated sites were investigated to evaluate the effects of subsurface heterogeneity using a vertically integrated three-phase flow model. The input stochastic variable of the areal flow analysis was the log-intrinsic permeability and it was generated using the Turning Band method. The results of a series of hypothetical field-scale simulations showed that subsurface heterogeneity has a substantial effect on free-product recovery predictions. As the heterogeneity increased, the recoverable oil volume decreased and the residual trapped oil volume increased. As the subsurface anisotropy increased, these effects together with free- and total-oil contaminated areas were further enhanced. The use of multiple-stage water pumping was found to be insignificant compared to steady uniform pumping due to reduced recovery efficiency and increased residual oil volume. This observation was opposite to that produced under homogeneous scenarios. The effect of subsurface heterogeneity was enhanced at relatively low water pumping rates. The difference in results produced by homogeneous and heterogeneous simulations was substantial, indicating greater attention should be paid in modeling free-product recovery systems with appropriate subsurface heterogeneity.

Research of working pulsation in closed angle based on rotating-sleeve distributing-flow system

NASA Astrophysics Data System (ADS)

Zhang, Yanjun; Zhang, Hongxin; Zhao, Qinghai; Jiang, Xiaotian; Cheng, Qianchang

2017-08-01

In order to reduce negative effects including hydraulic impact, noise and mechanical vibration, compression and expansion of piston pump in closed volume are used to optimize the angle between valve port and chamber. In addition, the mathematical model about pressurization and depressurization in pump chamber are analyzed based on distributing-flow characteristic, and it is necessary to use simulation software Fluent to simulate the distributing-flow fluid model so as to select the most suitable closed angle. As a result, when compression angle is 3°, the angle is closest to theoretical analysis and has the minimum influence on flow and pump pressure characteristic. Meanwhile, cavitation phenomenon appears in pump chamber in different closed angle on different degrees. Besides the flow pulsation is increasingly smaller with increasing expansion angle. Thus when expansion angle is 2°, the angle is more suitable for distributing-flow system.

Development of standardized air-blown coal gasifier/gas turbine concepts for future electric power systems, Volume 4. Appendix C: Design and performance of standardized fixed bed air-blown gasifier IGCC systems for future electric power generation: Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1991-02-01

This appendix is a compilation of work done to predict overall cycle performance from gasifier to generator terminals. A spreadsheet has been generated for each case to show flows within a cycle. The spreadsheet shows gaseous or solid composition of flow, temperature of flow, quantity of flow, and heat heat content of flow. Prediction of steam and gas turbine performance was obtained by the computer program GTPro. Outputs of all runs for each combined cycle reviewed has been added to this appendix. A process schematic displaying all flows predicted through GTPro and the spreadsheet is also added to this appendix.more » The numbered bubbles on the schematic correspond to columns on the top headings of the spreadsheet.« less

Conceptual model of the uppermost principal aquifer systems in the Williston and Powder River structural basins, United States and Canada

USGS Publications Warehouse

Long, Andrew J.; Aurand, Katherine R.; Bednar, Jennifer M.; Davis, Kyle W.; McKaskey, Jonathan D.R.G.; Thamke, Joanna N.

2014-01-01

The three uppermost principal aquifer systems of the Northern Great Plains—the glacial, lower Tertiary, and Upper Cretaceous aquifer systems—are described in this report and provide water for irrigation, mining, public and domestic supply, livestock, and industrial uses. These aquifer systems primarily are present in two nationally important fossil-fuelproducing areas: the Williston and Powder River structural basins in the United States and Canada. The glacial aquifer system is contained within glacial deposits that overlie the lower Tertiary and Upper Cretaceous aquifer systems in the northeastern part of the Williston structural basin. Productive sand and gravel aquifers exist within this aquifer system. The Upper Cretaceous aquifer system is contained within bedrock lithostratigraphic units as deep as 2,850 and 8,500 feet below land surface in the Williston and Powder River structural basins, respectively. Petroleum extraction from much deeper formations, such as the Bakken Formation, is rapidly increasing because of recently improved hydraulic fracturing methods that require large volumes of relatively freshwater from shallow aquifers or surface water. Extraction of coalbed natural gas from within the lower Tertiary aquifer system requires removal of large volumes of groundwater to allow degasification. Recognizing the importance of understanding water resources in these energy-rich basins, the U.S. Geological Survey (USGS) Groundwater Resources Program (http://water.usgs.gov/ogw/gwrp/) began a groundwater study of the Williston and Powder River structural basins in 2011 to quantify this groundwater resource, the results of which are described in this report. The overall objective of this study was to characterize, quantify, and provide an improved conceptual understanding of the three uppermost and principal aquifer systems in energy-resource areas of the Northern Great Plains to assist in groundwater-resource management for multiple uses. The study area includes parts of Montana, North Dakota, South Dakota, and Wyoming in the United States and Manitoba and Saskatchewan in Canada. The glacial aquifer system is contained within glacial drift consisting primarily of till, with smaller amounts of glacial outwash sand and gravel deposits. The lower Tertiary and Upper Cretaceous aquifer systems are contained within several formations of the Tertiary and Cretaceous geologic systems, which are hydraulically separated from underlying aquifers by a basal confining unit. The lower Tertiary and Upper Cretaceous aquifer systems each were divided into three hydrogeologic units that correspond to one or more lithostratigraphic units. The period prior to 1960 is defined as the predevelopment period when little groundwater was extracted. From 1960 through 1990, numerous flowing wells were installed near the Yellowstone, Little Missouri and Knife Rivers, resulting in local groundwater declines. Recently developed technologies for the extraction of petroleum resources, which largely have been applied in the study area since about 2005, require millions of gallons of water for construction of each well, with additional water needed for long-term operation; therefore, the potential for an increase in groundwater extraction is high. In this study, groundwater recharge and discharge components were estimated for the period 1981–2005. Groundwater recharge primarily occurs from infiltration of rainfall and snowmelt (precipitation recharge) and infiltration of streams into the ground (stream infiltration). Total estimated recharge to the Williston and Powder River control volumes is 4,560 and 1,500 cubic feet per second, respectively. Estimated precipitation recharge is 26 and 15 percent of total recharge for the Williston and Powder River control volumes, respectively. Estimated stream infiltration is 71 and 80 percent of total recharge for the Williston and Powder River control volumes, respectively. Groundwater discharge primarily is to streams and springs and is estimated to be about 97 and 92 percent of total discharge for the Williston and Powder River control volumes, respectively. Most of the remaining discharge results from pumped and flowing wells. Groundwater flow in the Williston structural basin generally is from the west and southwest toward the east, where discharge to streams occurs. Locally, in the uppermost hydrogeologic units, groundwater generally is unconfined and flows from topographically high to low areas, where discharge to streams occurs. Groundwater flow in the Powder River structural basin generally is toward the north, with local variations, particularly in the upper Fort Union aquifer, where flow is toward streams.

Variable thickness transient ground-water flow model. Volume 1. Formulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reisenauer, A.E.

1979-12-01

Mathematical formulation for the variable thickness transient (VTT) model of an aquifer system is presented. The basic assumptions are described. Specific data requirements for the physical parameters are discussed. The boundary definitions and solution techniques of the numerical formulation of the system of equations are presented.

The Renal Renin-Angiotensin System

ERIC Educational Resources Information Center

Harrison-Bernard, Lisa M.

2009-01-01

The renin-angiotensin system (RAS) is a critical regulator of sodium balance, extracellular fluid volume, vascular resistance, and, ultimately, arterial blood pressure. In the kidney, angiotensin II exerts its effects to conserve salt and water through a combination of the hemodynamic control of renal blood flow and glomerular filtration rate and…

Are we fully utilizing the functionalities of modern operating room ventilators?

PubMed

Liu, Shujie; Kacmarek, Robert M; Oto, Jun

2017-12-01

The modern operating room ventilators have become very sophisticated and many of their features are comparable with those of an ICU ventilator. To fully utilize the functionality of modern operating room ventilators, it is important for clinicians to understand in depth the working principle of these ventilators and their functionalities. Piston ventilators have the advantages of delivering accurate tidal volume and certain flow compensation functions. Turbine ventilators have great ability of flow compensation. Ventilation modes are mainly volume-based or pressure-based. Pressure-based ventilation modes provide better leak compensation than volume-based. The integration of advanced flow generation systems and ventilation modes of the modern operating room ventilators enables clinicians to provide both invasive and noninvasive ventilation in perioperative settings. Ventilator waveforms can be used for intraoperative neuromonitoring during cervical spine surgery. The increase in number of new features of modern operating room ventilators clearly creates the opportunity for clinicians to optimize ventilatory care. However, improving the quality of ventilator care relies on a complete understanding and correct use of these new features. VIDEO ABSTRACT: http://links.lww.com/COAN/A47.

Detection technology for IVHS : Volume I: Final Report

DOT National Transportation Integrated Search

1996-12-01

The Detection Technology for the IVHS project identified traffic parameters and their required accuracies for characterizing traffic flow in conventional and newer intelligent transportation systems (ITS); obtained state-of-the-art detectors and inst...

A simulation model for wind energy storage systems. Volume 3: Program descriptions

NASA Technical Reports Server (NTRS)

Warren, A. W.; Edsinger, R. W.; Burroughs, J. D.

1977-01-01

Program descriptions, flow charts, and program listings for the SIMWEST model generation program, the simulation program, the file maintenance program, and the printer plotter program are given. For Vol 2, see .

Freight story 2008.

DOT National Transportation Integrated Search

2008-11-01

This report provides an overview of freight movement on the U.S. transportation system today and in the future. It discusses where the largest freight flows are concentrated and the pressures that existing and anticipated freight volumes place on the...

Vortex Imprints at the Wall, But Not in the Bulk, Distinguish Ruptured from Unruptured Intracranial Aneurysms

NASA Astrophysics Data System (ADS)

Varble, Nicole; Meng, Hui

2015-11-01

Intracranial aneurysms affect 3% of the population. Risk stratification of aneurysms is important, as rupture often leads to death or permanent disability. Image-based CFD analyses of patient-specific aneurysms have identified low and oscillatory wall shear stress to predict rupture. These stresses are sensed biologically at the luminal wall, but the flow dynamics related to aneurysm rupture requires further understanding. We have conducted two studies: one examines vortex dynamics, and the other, high frequency flow fluctuations in patient-specific aneurysms. In the first study, based on Q-criterion vortex identification, we developed two measures to quantify regions within the aneurysm where rotational flow is dominate: the ratio of volume or surface area where Q >0 vs. the total aneurysmal volume or surface area, respectively termed volume vortex fraction (VVF) and surface vortex fraction (SVF). Statistical analysis of 204 aneurysms shows that SVF, but not VVF, distinguishes ruptured from unruptured aneurysms, suggesting that once again, the local flow patterns on the wall is directly relevant to rupture. In the second study, high-resolution CFD (high spatial and temporal resolutions and second-order discretization schemes) on 56 middle cerebral artery aneurysms shows the presence of temporal fluctuations in 8 aneurysms, but such flow instability bears no correlation with rupture. Support for this work was partially provided by NIH grant (R01 NS091075-01) and a grant from Toshiba Medical Systems Corp.

Continuous-flow cardiac assistance: effects on aortic valve function in a mock loop.

PubMed

Tuzun, Egemen; Rutten, Marcel; Dat, Marco; van de Vosse, Frans; Kadipasaoglu, Cihan; de Mol, Bas

2011-12-01

As the use of left ventricular assist devices (LVADs) to treat end-stage heart failure has become more widespread, leaflet fusion--with resul-tant aortic regurgitation--has been observed more frequently. To quantitatively assess the effects of nonpulsatile flow on aortic valve function, we tested a continuous-flow LVAD in a mock circulatory system (MCS) with an interposed valve. To mimic the hemodynamic characteristics of LVAD patients, we utilized an MCS in which a Jarvik 2000 LVAD was positioned at the base of a servomotor-operated piston pump (left ventricular chamber). We operated the LVAD at 8000 to 12,000 rpm, changing the speed in 1000-rpm increments. At each speed, we first varied the outflow resistance at a constant stroke volume, then varied the stroke volume at a constant outflow resistance. We measured the left ventricular pressure, aortic pressure, pump flow, and total flow, and used these values to compute the change, if any, in the aortic duty cycle (aortic valve open time) and transvalvular aortic pressure loads. Validation of the MCS was demonstrated by the simulation of physiologic pressure and flow waveforms. At increasing LVAD speeds, the mean aortic pressure load steadily increased, while the aortic duty cycle steadily decreased. Changes were consistent for each MCS experimental setting, despite variations in stroke volume and outflow resistance. Increased LVAD flow results in an impaired aortic valve-open time due to a pressure overload above the aortic valve. Such an overload may initiate structural changes, causing aortic leaflet fusion and/or regurgitation. Copyright © 2011 Elsevier Inc. All rights reserved.

Extended parametric representation of compressor fans and turbines. Volume 2: Part user's manual (parametric turbine)

NASA Technical Reports Server (NTRS)

Coverse, G. L.

1984-01-01

A turbine modeling technique has been developed which will enable the user to obtain consistent and rapid off-design performance from design point input. This technique is applicable to both axial and radial flow turbine with flow sizes ranging from about one pound per second to several hundred pounds per second. The axial flow turbines may or may not include variable geometry in the first stage nozzle. A user-specified option will also permit the calculation of design point cooling flow levels and corresponding changes in efficiency for the axial flow turbines. The modeling technique has been incorporated into a time-sharing program in order to facilitate its use. Because this report contains a description of the input output data, values of typical inputs, and example cases, it is suitable as a user's manual. This report is the second of a three volume set. The titles of the three volumes are as follows: (1) Volume 1 CMGEN USER's Manual (Parametric Compressor Generator); (2) Volume 2 PART USER's Manual (Parametric Turbine); (3) Volume 3 MODFAN USER's Manual (Parametric Modulation Flow Fan).

Network, system, and status software enhancements for the autonomously managed electrical power system breadboard. Volume 4: Graphical status display

NASA Technical Reports Server (NTRS)

Mckee, James W.

1990-01-01

This volume (4 of 4) contains the description, structured flow charts, prints of the graphical displays, and source code to generate the displays for the AMPS graphical status system. The function of these displays is to present to the manager of the AMPS system a graphical status display with the hot boxes that allow the manager to get more detailed status on selected portions of the AMPS system. The development of the graphical displays is divided into two processes; the creation of the screen images and storage of them in files on the computer, and the running of the status program which uses the screen images.

Flow volume loops in patients with goiters.

PubMed Central

Geraghty, J G; Coveney, E C; Kiernan, M; O'Higgins, N J

1992-01-01

Plain radiology is the standard means of assessing upper airway obstruction in patients with goiters. Flow volume loop curves will provide additional information, because they allow a quantitative assessment of airflow dynamics in the respiratory cycle. Fifty-one patients had flow volume loops performed before and after thyroidectomy. There was a significant increase in the maximum inspiratory flow rate (3.9 +/- 0.2 versus 4.9 +/- 0.2 L/second, p less than 0.01) after thyroidectomy. Eight of twelve patients with normal tracheal radiology had improved airflow dynamics in the postoperative period. The flow volume loop curve is a simple noninvasive means of assessing airflow dynamics in patients with goiters and may be superior to conventional radiology. PMID:1731653

Large volume preconcentration and determination of nanomolar concentrations of iron in seawater using a renewable cellulose 8-hydroquinoline sorbent microcolumn and universal approach of post-column eluate utilization in a Lab-on-Valve system.

PubMed

Horstkotte, Burkhard; Chocholouš, Petr; Solich, Petr

2016-04-01

We report on a Lab-On-Valve (LOV) configuration for analyte preconcentration from milliliter sample volumes using confluent mixing in the holding coil for in-line addition of loading buffer. The system was applied to the spectrophotometric determination of iron(II) in acidified seawater using 1,10-phenanthroline as color reagent. A cellulose-based chelating sorbent containing 8-hydroxyquinoline was used for the first time in LOV and excellent retention behavior and loading capacity were found. The flow system employs a syringe pump for handling all solutions (sorbent suspension, loading buffer, water, eluent, and color reagent) and a peristaltic pump for sample propulsion and includes a fit-for-purpose 14 cm long detection glass flow cell and a bubble trap for in-line carrier degasification. Advantage was taken of the LOV flow-through port to keep the eluted analytes for re-aspiration for subsequent chromogenic reaction. In effect, a universal analyzer configuration and preconcentration procedure was developed, which is combinable with other analytes, sorbents, and reagents. Among the studied parameters were the compositions, pH, volumes, and flow rates of loading buffer, eluent, and color reagent, as well as the microcolumn size, repeatability, and system stability. Reproducibility of 4.1% RSD over the entire working range, a LOD of down to 5 nmol L(-1), sampling frequency of 12h(-1), and linearity up to 1 µmol L(-1) for 3.3 mL of sample were obtained and applicability to real samples was demonstrated. It was proven that both Fe(III) and Fe(II) were retained and yielded similar recovery and sensitivity values. The method was applied to coastal seawater samples and spiking experiments yielded recovery values close to 100%. Copyright © 2015 Elsevier B.V. All rights reserved.

Design integration and noise studies for jet STOL aircraft. Task 7A: Augmentor wing cruise blowing valveless system. Volume 1: System design and test integration

NASA Technical Reports Server (NTRS)

Roepcke, F. A.; Nickson, T. B.

1973-01-01

Exploratory design studies conducted to establish the configuration of an augmentor wing vruise blowing (valveless) system in a 150-passenger STOL airplane were reported in NASA CR-114570. Those studies have been updated to incorporate the results of static rig, flow duct, and wind tunnel tests. Minor adjustments in duct flow velocity, flap length, and blowing nozzle geometry were incorporated to provide airplane characteristics that minimize takeoff gross weight and achieve sideline noise objectives for an advanced commercial STOL airplane.

Variable volume combustor with nested fuel manifold system

DOEpatents

McConnaughhay, Johnie Franklin; Keener, Christopher Paul; Johnson, Thomas Edward; Ostebee, Heath Michael

2016-09-13

The present application provides a combustor for use with a gas turbine engine. The combustor may include a number of micro-mixer fuel nozzles, a fuel manifold system in communication with the micro-mixer fuel nozzles to deliver a flow of fuel thereto, and a linear actuator to maneuver the micro-mixer fuel nozzles and the fuel manifold system.

Disabled personnel emergency-heating system. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Van Dine, N.

1974-12-16

This progress report describes a receiving well for the operating fuel supply (two provided) designed within the unit to permit parasitic heat loss from the system to be captured by the fuel supply. The Zero can housing provides adequate volume to accommodate stowage of the fluid-flow umbilicals for connection of the heater system to the tubulated casualty bag liner.

SU-E-J-48: Development of An Abdominal Compression Device for Respiratory Correlated Radiation Therapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, T; Kang, S; Kim, D

Purpose: The aim of this study is to develop the abdominal compression device which could control pressure level according to the abdominal respiratory motion and evaluate its feasibility. Methods: In this study, we focused on developing the abdominal compression device which could control pressure level at any point of time so the developed device is possible to use a variety of purpose (gating technique or respiratory training system) while maintaining the merit of the existing commercial device. The compression device (air pad form) was designed to be able to compress the front and side of abdomen and the pressure levelmore » of the abdomen is controlled by air flow. Pressure level of abdomen (air flow) was determined using correlation data between external abdominal motion and respiratory volume signal measured by spirometer. In order to verify the feasibility of the device, it was necessary to confirm the correlation between the abdominal respiratory motion and respiratory volume signal and cooperation with respiratory training system also checked. Results: In the previous study, we could find that the correlation coefficient ratio between diaphragm and respiratory volume signal measured by spirometer was 0.95. In this study, we confirmed the correlation between the respiratory volume signal and the external abdominal motion measured by belt-transducer (correlation coefficient ratio was 0.92) and used the correlated respiratory volume data as an abdominal pressure level. It was possible to control the pressure level with negligible time delay and respiratory volume data based guiding waveforms could be properly inserted into the respiratory training system. Conclusion: Through this feasibility study, we confirmed the correlation between the respiratory volume signal and the external abdominal motion. Also initial assessment of the device and its compatibility with the respiratory training system were verified. Further study on application in respiratory gated therapy and respiratory training system will be investigated. This work was supported by Radiation Technology R and D program (No. 2013M2A2A7043498)and Basic Atomic Energy Research Institute (BAERI)(No. NRF-2009-0078390) through the National Research Foundation of Korea funded by the Ministry of Science, ICT and Future Planning.« less

The Progress in the Novel Pediatric Rotary Blood Pump Sputnik Development.

PubMed

Telyshev, Dmitry; Denisov, Maxim; Pugovkin, Alexander; Selishchev, Sergey; Nesterenko, Igor

2018-04-01

In this work, the study results of an implantable pediatric rotary blood pump (PRBP) are presented. They show the results of the numerical simulation of fluid flow rates in the pump. The determination method of the backflows and stagnation regions is represented. The operating points corresponding to fluid flow rates of 1, 3, and 5 L/min for 75-80 mm Hg pressure head are investigated. The study results have shown that use of the pump in the 1 L/min operating point can potentially lead to the appearance of backflows and stagnation regions. In the case of using pumps in fluid flow rates ranging from 3 to 5 L/min, the number of stagnation regions decreases and the fluid flow rate changes marginally. Using the pump in this flow rate range is considered judicious. The study shows an increase in shear stress with an increase in fluid flow rates, while there is no increase in shear stress above the critical condition of 150 Pa (which does not allow us to reliably speak about the increased risk of blood cell damage). The aim of this work was to design, prototype, and study interaction of the Sputnik PRBP with the cardiovascular system. A three-dimensional model of Sputnik PRBP was designed with the following geometrical specifications: flow unit length of 51.5 mm, flow unit diameter of 10 mm, and spacing between the rotor and housing of 0.1 mm. Computational fluid dynamics studies were used to calculate head pressure-flow rate (H-Q) curves at rotor speeds ranging from 10 000 to 14 000 rpm (R 2  = 0.866 between numerical simulation and experiment) and comparing flow patterns at various points of the flow rate operating range (1, 3, and 5 L/min) for operating pressures ranging from 75 to 80 mm Hg. It is noted that when fluid flow rate changes from 1 L/min to 3 L/min, significant changes are observed in the distribution of zero flow zones. At the inlet and outlet of the pump, when going to the operating point of 3 L/min, zones of stagnation become minuscule. The shear stress distribution was calculated along the pump volume. The volume in which shear stress exceed 150 Pa is less than 0.38% of the total pump volume at flow rates of 1, 3, and 5 L/min. In this study, a mock circulatory system (MCS) allowing simulation of physiological cardiovascular characteristics was used to investigate the interaction of the Sputnik PRBP with the cardiovascular system. MCS allows reproducing the Frank-Starling autoregulation mechanism of the heart. PRBP behavior was tested in the speed range of 6 000 to 15 000 rpm. Decreased contractility can be expressed in a stroke volume decrease approximately from 18 to 4 mL and ventricle systolic pressure decrease approximately from 92 to 20 mm Hg. The left ventricle becomes fully supported at a pump speed of 10 000 rpm. At a pump speed of 14 000 rpm, the left ventricle goes into a suction state in which fluid almost does not accumulate in the ventricle and only passes through it to the pump. The proposed PRBP showed potential for improved clinical outcomes in pediatric patients with a body surface area greater than 0.6 m 2 and weight greater than 12 kg. © 2018 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.

Implicit method for the computation of unsteady flows on unstructured grids

NASA Technical Reports Server (NTRS)

Venkatakrishnan, V.; Mavriplis, D. J.

1995-01-01

An implicit method for the computation of unsteady flows on unstructured grids is presented. Following a finite difference approximation for the time derivative, the resulting nonlinear system of equations is solved at each time step by using an agglomeration multigrid procedure. The method allows for arbitrarily large time steps and is efficient in terms of computational effort and storage. Inviscid and viscous unsteady flows are computed to validate the procedure. The issue of the mass matrix which arises with vertex-centered finite volume schemes is addressed. The present formulation allows the mass matrix to be inverted indirectly. A mesh point movement and reconnection procedure is described that allows the grids to evolve with the motion of bodies. As an example of flow over bodies in relative motion, flow over a multi-element airfoil system undergoing deployment is computed.

Evaluation of a new 3-dimensional color Doppler flow method to quantify flow across the mitral valve and in the left ventricular outflow tract: an in vitro study.

PubMed

Kimura, Sumito; Streiff, Cole; Zhu, Meihua; Shimada, Eriko; Datta, Saurabh; Ashraf, Muhammad; Sahn, David J

2014-02-01

The aim of this study was to assess the accuracy, feasibility, and reproducibility of determining stroke volume from a novel 3-dimensional (3D) color Doppler flow quantification method for mitral valve (MV) inflow and left ventricular outflow tract (LVOT) outflow at different stroke volumes when compared with the actual flow rate in a pumped porcine cardiac model. Thirteen freshly harvested pig hearts were studied in a water tank. We inserted a latex balloon into each left ventricle from the MV annulus to the LVOT, which were passively pumped at different stroke volumes (30-80 mL) using a calibrated piston pump at increments of 10 mL. Four-dimensional flow volumes were obtained without electrocardiographic gating. The digital imaging data were analyzed offline using prototype software. Two hemispheric flow-sampling planes for color Doppler velocity measurements were placed at the MV annulus and LVOT. The software computed the flow volumes at the MV annulus and LVOT within the user-defined volume and cardiac cycle. This novel 3D Doppler flow quantification method detected incremental increases in MV inflow and LVOT outflow in close agreement with pumped stroke volumes (MV inflow, r = 0.96; LVOT outflow, r = 0.96; P < .01). Bland-Altman analysis demonstrated overestimation of both (MV inflow, 5.42 mL; LVOT outflow, 4.46 mL) with 95% of points within 95% limits of agreement. Interobserver variability values showed good agreement for all stroke volumes at both the MV annulus and LVOT. This study has shown that the 3D color Doppler flow quantification method we used is able to compute stroke volumes accurately at the MV annulus and LVOT in the same cardiac cycle without electrocardiographic gating. This method may be valuable for assessment of cardiac output in clinical studies.

A study of unsteady physiological magneto-fluid flow and heat transfer through a finite length channel by peristaltic pumping.

PubMed

Tripathi, Dharmendra; Bég, O Anwar

2012-08-01

Magnetohydrodynamic peristaltic flows arise in controlled magnetic drug targeting, hybrid haemodynamic pumps and biomagnetic phenomena interacting with the human digestive system. Motivated by the objective of improving an understanding of the complex fluid dynamics in such flows, we consider in the present article the transient magneto-fluid flow and heat transfer through a finite length channel by peristaltic pumping. Reynolds number is small enough and the wavelength to diameter ratio is large enough to negate inertial effects. Analytical solutions for temperature field, axial velocity, transverse velocity, pressure gradient, local wall shear stress, volume flowrate and averaged volume flowrate are obtained. The effects of the transverse magnetic field, Grashof number and thermal conductivity on the flow patterns induced by peristaltic waves (sinusoidal propagation along the length of channel) are studied using graphical plots. The present study identifies that greater pressure is required to propel the magneto-fluid by peristaltic pumping in comparison to a non-conducting Newtonian fluid, whereas, a lower pressure is required if heat transfer is effective. The analytical solutions further provide an important benchmark for future numerical simulations.

Breathing simulator of workers for respirator performance test

PubMed Central

YUASA, Hisashi; KUMITA, Mikio; HONDA, Takeshi; KIMURA, Kazushi; NOZAKI, Kosuke; EMI, Hitoshi; OTANI, Yoshio

2014-01-01

Breathing machines are widely used to evaluate respirator performance but they are capable of generating only limited air flow patterns, such as, sine, triangular and square waves. In order to evaluate the respirator performance in practical use, it is desirable to test the respirator using the actual breathing patterns of wearers. However, it has been a difficult task for a breathing machine to generate such complicated flow patterns, since the human respiratory volume changes depending on the human activities and workload. In this study, we have developed an electromechanical breathing simulator and a respiration sampling device to record and reproduce worker’s respiration. It is capable of generating various flow patterns by inputting breathing pattern signals recorded by a computer, as well as the fixed air flow patterns. The device is equipped with a self-control program to compensate the difference in inhalation and exhalation volume and the measurement errors on the breathing flow rate. The system was successfully applied to record the breathing patterns of workers engaging in welding and reproduced the breathing patterns. PMID:25382381

Reinventing Emergency Department Flow via Healthcare Delivery Science.

PubMed

DeFlitch, Christopher; Geeting, Glenn; Paz, Harold L

2015-01-01

Healthcare system flow resulting in emergency departments (EDs) crowding is a quality and access problem. This case study examines an overcrowded academic health center ED with increasing patient volumes and limited physical space for expansion. ED capacity and efficiency improved via engineering principles application, addressing patient and staffing flows, and reinventing the delivery model. Using operational data and staff input, patient and staff flow models were created, identifying bottlenecks (points of inefficiency). A new flow model of emergency care delivery, physician-directed queuing, was developed. Expanding upon physicians in triage, providers passively evaluate all patients upon arrival, actively manage patients requiring fewer resources, and direct patients requiring complex resources to further evaluation in ED areas. Sustained over time, ED efficiency improved as measured by near elimination of "left without being seen" patients and waiting times with improvement in door to doctor, patient satisfaction, and total length of stay. All improvements were in the setting on increased patient volume and no increase in physician staffing. Our experience suggests that practical application of healthcare delivery science can be used to improve ED efficiency. © The Author(s) 2015.

Accuracy of tidal breathing measurement of FloRight compared to an ultrasonic flowmeter in infants.

PubMed

Petrus, Nicole C M; Thamrin, Cindy; Fuchs, Oliver; Frey, Urs

2015-04-01

Monitoring breathing pattern is especially relevant in infants with lung disease. Recently, a vest-based inductive plethysmograph system (FloRight®) has been developed for tidal breathing measurement in infants. We investigated the accuracy of tidal breathing flow volume loop (TBFVL) measurements in healthy term-born infants and infants with lung disease by the vest-based system in comparison to an ultrasonic flowmeter (USFM) with a face mask. We also investigated whether the system discriminates between healthy infants and those with lung disease. Floright® measures changes in thoracoabdominal volume during tidal breathing through magnetic field changes generated by current-carrying conductor coils in an elastic vest. Simultaneous TBFVL measurements by the vest-based system and the USFM were performed at 44 weeks corrected postmenstrual age during quiet unsedated sleep. TBFVL parameters derived by both techniques and within both groups were compared. We included 19 healthy infants and 18 infants with lung disease. Tidal volume per body weight derived by the vest-based system was significantly lower with a mean difference (95% CI) of -1.33 ml/kg (-1.73; -0.92), P < 0.001. Respiratory rate and ratio of time to peak tidal expiratory flow over total expiratory time (tPTEF/tE) did not differ between the two techniques. Both systems were able to discriminate between healthy infants and those with lung disease using tPTEF/tE. FloRight® accurately measures time indices and may discriminate between healthy infants and those with lung disease, but demonstrates differences in tidal volume measurements. It may be better suited to monitor breathing pattern than for TBFVL measurements. © 2014 Wiley Periodicals, Inc.

Preliminary design of an intermittent smoke flow visualization system

NASA Technical Reports Server (NTRS)

Ward, Donald T.; Myatt, James H.

1993-01-01

A prototype intermittent flow visualization system that was designed to study vortex flow field dynamics has been constructed and tested through its ground test phase. It produces discrete pulses of dense white smoke consisting of particles of terephthalic acid by the pulsing action of a fast-acting three-way valve. The trajectories of the smoke pulses can be tracked by a video imaging system without intruding in the flow around in flight. Two methods of pulsing the smoke were examined. The simplest and safest approach is to simply divert the smoke between the two outlet ports on the valve; this approach should be particularly effective if it were desired to inject smoke at two locations during the same test event. The second approach involves closing off one of the outlet ports to momentarily block the flow. The second approach requires careful control of valve dwell times to avoid excessive pressure buildup within the cartridge container. This method also increases the velocity of the smoke injected into the flow. The flow of the smoke has been blocked for periods ranging from 30 to 80 milliseconds, depending on the system volume and the length of time the valve is allowed to remain open between valve closings.

Combined Falling Drop/Open Port Sampling Interface System for Automated Flow Injection Mass Spectrometry

DOE PAGES

Van Berkel, Gary J.; Kertesz, Vilmos; Orcutt, Matt; ...

2017-11-07

The aim of this work was to demonstrate and to evaluate the analytical performance of a combined falling drop/open port sampling interface (OPSI) system as a simple noncontact, no-carryover, automated system for flow injection analysis with mass spectrometry. The falling sample drops were introduced into the OPSI using a widely available autosampler platform utilizing low cost disposable pipet tips and conventional disposable microtiter well plates. The volume of the drops that fell onto the OPSI was in the 7–15 μL range with an injected sample volume of several hundred nanoliters. Sample drop height, positioning of the internal capillary on themore » sampling end of the probe, and carrier solvent flow rate were optimized for maximum signal. Sample throughput, signal reproducibility, matrix effects, and quantitative analysis capability of the system were established using the drug molecule propranolol and its isotope labeled internal standard in water, unprocessed river water and two commercially available buffer matrices. A sample-to-sample throughput of ~45 s with a ~4.5 s base-to-base flow injection peak profile was obtained in these experiments. In addition, quantitation with minimally processed rat plasma samples was demonstrated with three different statin drugs (atorvastatin, rosuvastatin, and fluvastatin). Direct characterization capability of unprocessed samples was demonstrated by the analysis of neat vegetable oils. Employing the autosampler system for spatially resolved liquid extraction surface sampling exemplified by the analysis of propranolol and its hydroxypropranolol glucuronide phase II metabolites from a rat thin tissue section was also illustrated.« less

Combined Falling Drop/Open Port Sampling Interface System for Automated Flow Injection Mass Spectrometry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Van Berkel, Gary J.; Kertesz, Vilmos; Orcutt, Matt

The aim of this work was to demonstrate and to evaluate the analytical performance of a combined falling drop/open port sampling interface (OPSI) system as a simple noncontact, no-carryover, automated system for flow injection analysis with mass spectrometry. The falling sample drops were introduced into the OPSI using a widely available autosampler platform utilizing low cost disposable pipet tips and conventional disposable microtiter well plates. The volume of the drops that fell onto the OPSI was in the 7–15 μL range with an injected sample volume of several hundred nanoliters. Sample drop height, positioning of the internal capillary on themore » sampling end of the probe, and carrier solvent flow rate were optimized for maximum signal. Sample throughput, signal reproducibility, matrix effects, and quantitative analysis capability of the system were established using the drug molecule propranolol and its isotope labeled internal standard in water, unprocessed river water and two commercially available buffer matrices. A sample-to-sample throughput of ~45 s with a ~4.5 s base-to-base flow injection peak profile was obtained in these experiments. In addition, quantitation with minimally processed rat plasma samples was demonstrated with three different statin drugs (atorvastatin, rosuvastatin, and fluvastatin). Direct characterization capability of unprocessed samples was demonstrated by the analysis of neat vegetable oils. Employing the autosampler system for spatially resolved liquid extraction surface sampling exemplified by the analysis of propranolol and its hydroxypropranolol glucuronide phase II metabolites from a rat thin tissue section was also illustrated.« less

CARS Temperature Measurements in a Hypersonic Propulsion Test Facility

NASA Technical Reports Server (NTRS)

Jarrett, Olin, Jr.; Smith, M. W.; Antcliff, R. R.; Northam, G. Burt; Cutler, A. D.; Capriotti, D. P.; Taylor, D. J.

1990-01-01

Nonintrusive diagnostic measurements were performed in the supersonic reacting flow of the Hypersonic Propulsion Test Cell 2 at NASA-Langley. A Coherent Anti-stokes Raman Spectroscopy (CARS) system was assembled specifically for the test cell environment. System design considerations were: (1) test cell noise and vibration; (2) contamination from flow field or atmospheric borne dust; (3) unwanted laser or electrically induced combustion (inside or outside the duct); (4) efficient signal collection; (5) signal splitting to span the wide dynamic range present throughout the flow field; (6) movement of the sampling volume in the flow; and (7) modification of the scramjet model duct to permit optical access to the reacting flow with the CARS system. The flow in the duct was a nominal Mach 2 flow with static pressure near one atmosphere. A single perpendicular injector introduced hydrogen into the flow behind a rearward facing step. CARS data was obtained in three planes downstream of the injection region. At least 20 CARS data points were collected at each of the regularly spaced sampling locations in each data plane. Contour plots of scramjet combustor static temperature in a reacting flow region are presented.

Improving visit cycle time using patient flow analysis in a high-volume inner-city hospital-based ambulatory clinic serving minority New Yorkers.

PubMed

Dhar, Sanjay; Michel, Raquel; Kanna, Balavenkatesh

2011-01-01

Patient waiting time and waiting room congestion are quality indicators that are related to efficiency of ambulatory care systems and patient satisfaction. Our main purpose was to test a program to decrease patient visit cycle time, while maintaining high-quality healthcare in a high-volume inner-city hospital-based clinic in New York City. Use of patient flow analysis and the creation of patient care teams proved useful in identifying areas for improvement, target, and measure effectiveness of interventions. The end result is reduced visit cycle time, improved provider team performance, and sustained patient care outcomes. © 2010 National Association for Healthcare Quality.

Design and Fabrication of a MEMS Flow Sensor and Its Application in Precise Liquid Dispensing

PubMed Central

Liu, Yaxin; Chen, Liguo; Sun, Lining

2009-01-01

A high speed MEMS flow sensor to enhance the reliability and accuracy of a liquid dispensing system is proposed. Benefitting from the sensor information feedback, the system can self-adjust the open time of the solenoid valve to accurately dispense desired volumes of reagent without any pre-calibration. First, an integrated high-speed liquid flow sensor based on the measurement of the pressure difference across a flow channel is presented. Dimensions of the micro-flow channel and two pressure sensors have been appropriately designed to meet the static and dynamic requirements of the liquid dispensing system. Experiments results show that the full scale (FS) flow measurement ranges up to 80 μL/s, with a nonlinearity better than 0.51% FS. Secondly, a novel closed-loop control strategy is proposed to calculate the valve open time in each dispensing cycle, which makes the system immune to liquid viscosity, pressure fluctuation, and other sources of error. Finally, dispensing results show that the system can achieve better dispensing performance, and the coefficient of variance (CV) for liquid dispensing is below 3% at 1 μL and below 4% at 100 nL. PMID:22408517

Design and Fabrication of a MEMS Flow Sensor and Its Application in Precise Liquid Dispensing.

PubMed

Liu, Yaxin; Chen, Liguo; Sun, Lining

2009-01-01

A high speed MEMS flow sensor to enhance the reliability and accuracy of a liquid dispensing system is proposed. Benefitting from the sensor information feedback, the system can self-adjust the open time of the solenoid valve to accurately dispense desired volumes of reagent without any pre-calibration. First, an integrated high-speed liquid flow sensor based on the measurement of the pressure difference across a flow channel is presented. Dimensions of the micro-flow channel and two pressure sensors have been appropriately designed to meet the static and dynamic requirements of the liquid dispensing system. Experiments results show that the full scale (FS) flow measurement ranges up to 80 μL/s, with a nonlinearity better than 0.51% FS. Secondly, a novel closed-loop control strategy is proposed to calculate the valve open time in each dispensing cycle, which makes the system immune to liquid viscosity, pressure fluctuation, and other sources of error. Finally, dispensing results show that the system can achieve better dispensing performance, and the coefficient of variance (CV) for liquid dispensing is below 3% at 1 μL and below 4% at 100 nL.

Investigation of Rotating Stall Phenomena in Axial Flow Compressors. Volume I. Basic Studies of Rotating Stall

DTIC Science & Technology

1976-06-01

rotating stall control system which was tested both on a low speed rig and a J-85-S engine. The second objective was to perform fundamental studies of the...Stator Stage 89 6 Annular Cascade Configuration Used for Rotating Stall Studies on Rotoi-Stator Stage ..... .............. ... 90 7 Static Pressure Rise...ground tests on a J-8S-S turbojet engine. The work i3 reported in three separate volumes. Volume I entitled, "Basic Studies of Rotating Stall", covers

Transportation Energy Conservation Data Book: A Selected Bibliography. Edition 3,

DTIC Science & Technology

1978-11-01

Charlottesville, VA 22901 TITLE: Couputer-Based Resource Accounting Model TT1.1: Methodology for the Design of Urban for Automobile Technology Impact...Evaluation System ACCOUNTING; INDUSTRIAL SECTOR; ENERGY tPIESi Documentation. volume 6. CONSUM PTION: PERFORANCE: DESIGN : NASTE MEAT: Methodology for... Methodology for the Design of Urban Transportation 000172 Energy Flows In the U.S., 1973 and 1974. Volume 1: Methodology * $opdate to the Fational Energy

Literature Review of Low Impact Development for Stormwater Control

DTIC Science & Technology

2015-05-30

appropriate LID technology can be selected to capture the targeted vi metal pollutant. Little information exists on the effects of field variables such as...loading rates and volume, temperature , climate, pH, sediments, organics, and maintenance cycles on systems in the field. 4. The amount of research...maximum extent technically feasible, the pre-development hydrology of the property with regard to the temperature , rate, volume, and duration of flow

A compact and low-cost laser induced fluorescence detector with silicon based photodetector assembly for capillary flow systems.

PubMed

Geng, Xuhui; Shi, Meng; Ning, Haijing; Feng, Chunbo; Guan, Yafeng

2018-05-15

A compact and low-cost laser induced fluorescence (LIF) detector based on confocal structure for capillary flow systems was developed and applied for analysis of Her2 protein on single Hela cells. A low-power and low-cost 450 nm laser diode (LD) instead of a high quality laser was used as excitation light source. A compact optical design together with shortened optical path length improved the optical efficiency and detection sensitivity. A superior silicon based photodetector assembly was used for fluorescence detection instead of a photomultiplier (PMT). The limit of detection (LOD) for fluorescein sodium was 3 × 10 -12 M or 165 fluorescein molecules in detection volume measured on a homemade capillary electroosmotic driven (EOD)-LIF system, which was similar to commercial LIFs. Compared to commercial LIFs, the whole volume of our LIF was reduced to 1/2-1/3, and the cost was less than 1/3 of them. Copyright © 2018 Elsevier B.V. All rights reserved.

Postwildfire debris-flow hazard assessment of the area burned by the 2012 Little Bear Fire, south-central New Mexico

USGS Publications Warehouse

Tillery, Anne C.; Matherne, Anne Marie

2013-01-01

A preliminary hazard assessment was developed of the debris-flow potential from 56 drainage basins burned by the Little Bear Fire in south-central New Mexico in June 2012. The Little Bear Fire burned approximately 179 square kilometers (km2) (44,330 acres), including about 143 km2 (35,300 acres) of National Forest System lands of the Lincoln National Forest. Within the Lincoln National Forest, about 72 km2 (17,664 acres) of the White Mountain Wilderness were burned. The burn area also included about 34 km2 (8,500 acres) of private lands. Burn severity was high or moderate on 53 percent of the burn area. The area burned is at risk of substantial postwildfire erosion, such as that caused by debris flows and flash floods. A postwildfire debris-flow hazard assessment of the area burned by the Little Bear Fire was performed by the U.S. Geological Survey in cooperation with the U.S. Department of Agriculture Forest Service, Lincoln National Forest. A set of two empirical hazard-assessment models developed by using data from recently burned drainage basins throughout the intermountain Western United States was used to estimate the probability of debris-flow occurrence and volume of debris flows along the burn area drainage network and for selected drainage basins within the burn area. The models incorporate measures of areal burn extent and severity, topography, soils, and storm rainfall intensity to estimate the probability and volume of debris flows following the fire. Relative hazard rankings of postwildfire debris flows were produced by summing the estimated probability and volume ranking to illustrate those areas with the highest potential occurrence of debris flows with the largest volumes. The probability that a drainage basin could produce debris flows and the volume of a possible debris flow at the basin outlet were estimated for three design storms: (1) a 2-year-recurrence, 30-minute-duration rainfall of 27 millimeters (mm) (a 50 percent chance of occurrence in any given year); (2) a 10-year-recurrence, 30-minute-duration rainfall of 42 mm (a 10 percent chance of occurrence in any given year); and (3) a 25-year-recurrence, 30-minute-duration rainfall of 51 mm (a 4 percent chance of occurrence in any given year). Thirty-nine percent of the 56 drainage basins modeled have a high (greater than 80 percent) probability of debris flows in response to the 2-year design storm; 80 percent of the modeled drainage basins have a high probability of debris flows in response to the 25-year design storm. For debris-flow volume, 7 percent of the modeled drainage basins have an estimated debris-flow volume greater than 100,000 cubic meters (m3) in response to the 2-year design storm; 9 percent of the drainage basins are included in the greater than 100,000 m3 category for both the 10-year and the 25-year design storms. Drainage basins in the greater than 100,000 m3 volume category also received the highest combined hazard ranking. The maps presented herein may be used to prioritize areas where emergency erosion mitigation or other protective measures may be needed prior to rainstorms within these drainage basins, their outlets, or areas downstream from these drainage basins within the 2- to 3-year period of vulnerability. This work is preliminary and is subject to revision. The assessment herein is provided on the condition that neither the U.S. Geological Survey nor the U.S. Government may be held liable for any damages resulting from the authorized or unauthorized use of the assessment.

Variability in venom volume, flow rate and duration in defensive stings of five scorpion species.

PubMed

van der Meijden, Arie; Coelho, Pedro; Rasko, Mykola

2015-06-15

Scorpions have been shown to control their venom usage in defensive encounters, depending on the perceived threat. Potentially, the venom amount that is injected could be controlled by reducing the flow speed, the flow duration, or both. We here investigated these variables by allowing scorpions to sting into an oil-filled chamber, and recording the accreting venom droplets with high-speed video. The size of the spherical droplets on the video can then be used to calculate their volume. We recorded defensive stings of 20 specimens representing 5 species. Significant differences in the flow rate and total expelled volume were found between species. These differences are likely due to differences in overall size between the species. Large variation in both venom flow speed and duration are described between stinging events of single individuals. Both venom flow rate and flow duration correlate highly with the total expelled volume, indicating that scorpions may control both variables in order to achieve a desired end volume of venom during a sting. Copyright © 2015 Elsevier Ltd. All rights reserved.

Self-repair of cracks in brittle material systems

NASA Astrophysics Data System (ADS)

Dry, Carolyn M.

2016-04-01

One of the most effective uses for self repair is in material systems that crack because the cracks can allow the repair chemical to flow into the crack damage sites in all three dimensions. In order for the repair chemical to stay in the damage site and flow along to all the crack and repair there must be enough chemical to fill the entire crack. The repair chemical must be designed appropriately for the particular crack size and total volume of cracks. In each of the three examples of self repair in crackable brittle systems, the viscosity and chemical makeup and volume of the repair chemicals used is different for each system. Further the chemical delivery system has to be designed for each application also. Test results from self repair of three brittle systems are discussed. In "Self Repair of Concrete Bridges and Infrastructure" two chemicals were used due to different placements in bridges to repair different types of cracks- surface shrinkage and shear cracks, In "Airplane Wings and Fuselage, in Graphite" the composite has very different properties than the concrete bridges. In the graphite for airplane components the chemical also had to survive the high processing temperatures. In this composite the cracks were so definite and deep and thin that the repair chemical could flow easily and repair in all layers of the composite. In "Ceramic/Composite Demonstrating Self Repair" the self repair system not only repaired the broken ceramic but also rebounded the composite to the ceramic layer

Estimating flow rates to optimize winter habitat for centrarchid fish in Mississippi River (USA) backwaters

USGS Publications Warehouse

Johnson, Barry L.; Knights, Brent C.; Barko, John W.; Gaugush, Robert F.; Soballe, David M.; James, William F.

1998-01-01

The backwaters of large rivers provide winter refuge for many riverine fish, but they often exhibit low dissolved oxygen levels due to high biological oxygen demand and low flows. Introducing water from the main channel can increase oxygen levels in backwaters, but can also increase current velocity and reduce temperature during winter, which may reduce habitat suitability for fish. In 1993, culverts were installed to introduce flow to the Finger Lakes, a system of six backwater lakes on the Mississippi River, about 160 km downstream from Minneapolis, Minnesota. The goal was to improve habitat for bluegills and black crappies during winter by providing dissolved oxygen concentrations >3 mg/L, current velocities <1 cm/s, and temperatures >1°C. To achieve these conditions, we used data on lake volume and oxygen demand to estimate the minimum flow required to maintain 3 mg/L of dissolved oxygen in each lake. Estimated flows ranged from 0.02 to 0.14 m3/s among lakes. Data gathered in winter 1994 after the culverts were opened, indicated that the estimated flows met habitat goals, but that thermal stratification and lake morphometry can reduce the volume of optimal habitat created.

Debris flow hazard mapping, Hobart, Tasmania, Australia

NASA Astrophysics Data System (ADS)

Mazengarb, Colin; Rigby, Ted; Stevenson, Michael

2015-04-01

Our mapping on the many dolerite capped mountains in Tasmania indicates that debris flows are a significant geomorphic process operating there. Hobart, the largest city in the State, lies at the foot of one of these mountains and our work is focussed on identifying areas that are susceptible to these events and estimating hazard in the valley systems where residential developments have been established. Geomorphic mapping with the benefit of recent LiDAR and GIS enabled stereo-imagery has allowed us to add to and refine a landslide inventory in our study area. In addition, a dominant geomorphic model has been recognised involving headward gully retreat in colluvial materials associated with rainstorms explains why many past events have occurred and where they may occur in future. In this paper we will review the landslide inventory including a large event (~200 000m3) in 1872 that affected a lightly populated area but since heavily urbanised. From this inventory we have attempted volume-mobility relationships, magnitude-frequency curves and likelihood estimates. The estimation of volume has been challenging to determine given that the area of depletion for each debris flow feature is typically difficult to distinguish from the total affected area. However, where LiDAR data exists, this uncertainty is substantially reduced and we develop width-length relationships (area of depletion) and area-volume relationships to estimate volume for the whole dataset exceeding 300 features. The volume-mobility relationship determined is comparable to international studies and in the absence of reliable eye-witness accounts, suggests that most of the features can be explained as single event debris flows, without requiring more complex mechanisms (such as those that form temporary debris dams that subsequently fail) as proposed by others previously. Likelihood estimates have also been challenging to derive given that almost all of the events have not been witnessed, some are constrained by aerial photographs to decade precision and many predate regional photography (pre 1940's). We have performed runout modelling, using 2D hydraulic modelling software (RiverFlow2D with Mud and Debris module), in order to calibrate our model against real events and gain confidence in the choice of parameters. Runout modelling was undertaken in valley systems with volumes calibrated to existing flood model likelihoods for each catchment. The hazard outputs from our models require developing a translation to hazard models used in Australia. By linking to flood mapping we aim to demonstrate to emergency managers where existing mitigation measures may be inadequate and how they can be adapted to address multiple hazards.

Enhanced Photoacoustic Gas Analyser Response Time and Impact on Accuracy at Fast Ventilation Rates during Multiple Breath Washout

PubMed Central

Horsley, Alex; Macleod, Kenneth; Gupta, Ruchi; Goddard, Nick; Bell, Nicholas

2014-01-01

Background The Innocor device contains a highly sensitive photoacoustic gas analyser that has been used to perform multiple breath washout (MBW) measurements using very low concentrations of the tracer gas SF6. Use in smaller subjects has been restricted by the requirement for a gas analyser response time of <100 ms, in order to ensure accurate estimation of lung volumes at rapid ventilation rates. Methods A series of previously reported and novel enhancements were made to the gas analyser to produce a clinically practical system with a reduced response time. An enhanced lung model system, capable of delivering highly accurate ventilation rates and volumes, was used to assess in vitro accuracy of functional residual capacity (FRC) volume calculation and the effects of flow and gas signal alignment on this. Results 10–90% rise time was reduced from 154 to 88 ms. In an adult/child lung model, accuracy of volume calculation was −0.9 to 2.9% for all measurements, including those with ventilation rate of 30/min and FRC of 0.5 L; for the un-enhanced system, accuracy deteriorated at higher ventilation rates and smaller FRC. In a separate smaller lung model (ventilation rate 60/min, FRC 250 ml, tidal volume 100 ml), mean accuracy of FRC measurement for the enhanced system was minus 0.95% (range −3.8 to 2.0%). Error sensitivity to flow and gas signal alignment was increased by ventilation rate, smaller FRC and slower analyser response time. Conclusion The Innocor analyser can be enhanced to reliably generate highly accurate FRC measurements down at volumes as low as those simulating infant lung settings. Signal alignment is a critical factor. With these enhancements, the Innocor analyser exceeds key technical component recommendations for MBW apparatus. PMID:24892522

User's manual for Axisymmetric Diffuser Duct (ADD) code. Volume 1: General ADD code description

NASA Technical Reports Server (NTRS)

Anderson, O. L.; Hankins, G. B., Jr.; Edwards, D. E.

1982-01-01

This User's Manual contains a complete description of the computer codes known as the AXISYMMETRIC DIFFUSER DUCT code or ADD code. It includes a list of references which describe the formulation of the ADD code and comparisons of calculation with experimental flows. The input/output and general use of the code is described in the first volume. The second volume contains a detailed description of the code including the global structure of the code, list of FORTRAN variables, and descriptions of the subroutines. The third volume contains a detailed description of the CODUCT code which generates coordinate systems for arbitrary axisymmetric ducts.

Fluvial valleys in the heavily cratered terrains of Mars: Evidence for paleoclimatic change?

NASA Technical Reports Server (NTRS)

Gulick, V. C.; Baker, V. R.

1993-01-01

Whether the formation of the Martian valley networks provides unequivocal evidence for drastically different climatic conditions remains debatable. Recent theoretical climate modeling precludes the existence of a temperate climate early in Mars' geological history. An alternative hypothesis suggests that Mars had a globally higher heat flow early in its geological history, bringing water tables to within 350 m of the surface. While a globally higher heat flow would initiate ground water circulation at depth, the valley networks probably required water tables to be even closer to the surface. Additionally, it was previously reported that the clustered distribution of the valley networks within terrain types, particularly in the heavily cratered highlands, suggests regional hydrological processes were important. The case for localized hydrothermal systems is summarized and estimates of both erosion volumes and of the implied water volumes for several Martian valley systems are presented.

Improving health systems performance in low- and middle-income countries: a system dynamics model of the pay-for-performance initiative in Afghanistan.

PubMed

Alonge, O; Lin, S; Igusa, T; Peters, D H

2017-12-01

System dynamics methods were used to explore effective implementation pathways for improving health systems performance through pay-for-performance (P4P) schemes. A causal loop diagram was developed to delineate primary causal relationships for service delivery within primary health facilities. A quantitative stock-and-flow model was developed next. The stock-and-flow model was then used to simulate the impact of various P4P implementation scenarios on quality and volume of services. Data from the Afghanistan national facility survey in 2012 was used to calibrate the model. The models show that P4P bonuses could increase health workers' motivation leading to higher levels of quality and volume of services. Gaming could reduce or even reverse this desired effect, leading to levels of quality and volume of services that are below baseline levels. Implementation issues, such as delays in the disbursement of P4P bonuses and low levels of P4P bonuses, also reduce the desired effect of P4P on quality and volume, but they do not cause the outputs to fall below baseline levels. Optimal effect of P4P on quality and volume of services is obtained when P4P bonuses are distributed per the health workers' contributions to the services that triggered the payments. Other distribution algorithms such as equal allocation or allocations proportionate to salaries resulted in quality and volume levels that were substantially lower, sometimes below baseline. The system dynamics models served to inform, with quantitative results, the theory of change underlying P4P intervention. Specific implementation strategies, such as prompt disbursement of adequate levels of performance bonus distributed per health workers' contribution to service, increase the likelihood of P4P success. Poorly designed P4P schemes, such as those without an optimal algorithm for distributing performance bonuses and adequate safeguards for gaming, can have a negative overall impact on health service delivery systems. © The Author 2017. Published by Oxford University Press in association with The London School of Hygiene and Tropical Medicine.

Direct measurement of proximal isovelocity surface area by real-time three-dimensional color Doppler for quantitation of aortic regurgitant volume: an in vitro validation.

PubMed

Pirat, Bahar; Little, Stephen H; Igo, Stephen R; McCulloch, Marti; Nosé, Yukihiko; Hartley, Craig J; Zoghbi, William A

2009-03-01

The proximal isovelocity surface area (PISA) method is useful in the quantitation of aortic regurgitation (AR). We hypothesized that actual measurement of PISA provided with real-time 3-dimensional (3D) color Doppler yields more accurate regurgitant volumes than those estimated by 2-dimensional (2D) color Doppler PISA. We developed a pulsatile flow model for AR with an imaging chamber in which interchangeable regurgitant orifices with defined shapes and areas were incorporated. An ultrasonic flow meter was used to calculate the reference regurgitant volumes. A total of 29 different flow conditions for 5 orifices with different shapes were tested at a rate of 72 beats/min. 2D PISA was calculated as 2pi r(2), and 3D PISA was measured from 8 equidistant radial planes of the 3D PISA. Regurgitant volume was derived as PISA x aliasing velocity x time velocity integral of AR/peak AR velocity. Regurgitant volumes by flow meter ranged between 12.6 and 30.6 mL/beat (mean 21.4 +/- 5.5 mL/beat). Regurgitant volumes estimated by 2D PISA correlated well with volumes measured by flow meter (r = 0.69); however, a significant underestimation was observed (y = 0.5x + 0.6). Correlation with flow meter volumes was stronger for 3D PISA-derived regurgitant volumes (r = 0.83); significantly less underestimation of regurgitant volumes was seen, with a regression line close to identity (y = 0.9x + 3.9). Direct measurement of PISA is feasible, without geometric assumptions, using real-time 3D color Doppler. Calculation of aortic regurgitant volumes with 3D color Doppler using this methodology is more accurate than conventional 2D method with hemispheric PISA assumption.

Sometimes There Is No Most-Vital Arc: Assessing and Improving the Operational Resilience of Systems

DTIC Science & Technology

2013-01-01

this problem in which the reduction in capacity on each in- terdicted arc is a random variable with known mean and variance , and the overall goal is...capacities will allow. A classic result in the theory of network flows states that the maximum flow volume is equal to the min- imum capacity of any cut, where...attack capability provides a natural means to assess the resilience of the system as a whole. This analysis yields a corollary result that common-sense

Local-Rapid Evaluation of Atmospheric Conditions (L-REAC) System, Design and Development Volume 5 (Mobile L-REAC System Proof of Concept and Four Feasibility Studies)

DTIC Science & Technology

2012-12-01

List of Symbols, Abbreviations, and Acronyms 52 Distribution List 56 v List of Figures Figure 1. 1994 EPA/NOAA wind tunnel results show the...Atmospheric Administration (NOAA) wind tunnel study. Six of the seven features are shown in figure 1: fetch flow, velocity acceleration, velocity deficit...Figure 1. 1994 EPA/NOAA wind tunnel results show the airflow pattern around a single structure. Streamline flow is from left to right. The “canyon

A simple counter-flow cooling system for a supersonic free-jet beam source assembly

NASA Astrophysics Data System (ADS)

Barr, M.; Fahy, A.; Martens, J.; Dastoor, P. C.

2016-05-01

A simple design for an inexpensive, cooled, free-jet beam source is described. The source assembly features an integrated cooling system as supplied by a counter-flow of chilled nitrogen, and is composed primarily of off-the-shelf tube fittings. The design facilitates rapid implementation and eases subsequent alignment with respect to any downstream beamline aperture. The source assembly outlined cools the full length of the stagnation volume, offering temperature control down to 100 K and long-term temperature stability better than ±1 K.

A simple counter-flow cooling system for a supersonic free-jet beam source assembly

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barr, M.; Fahy, A.; Martens, J.

2016-05-15

A simple design for an inexpensive, cooled, free-jet beam source is described. The source assembly features an integrated cooling system as supplied by a counter-flow of chilled nitrogen, and is composed primarily of off-the-shelf tube fittings. The design facilitates rapid implementation and eases subsequent alignment with respect to any downstream beamline aperture. The source assembly outlined cools the full length of the stagnation volume, offering temperature control down to 100 K and long-term temperature stability better than ±1 K.

Variable volume combustor with center hub fuel staging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ostebee, Heath Michael; McConnaughhay, Johnie Franklin; Stewart, Jason Thurman

The present application and the resultant patent provide a combustor for use with a gas turbine engine. The combustor may include a number of micro-mixer fuel nozzles and a fuel injection system for providing a flow of fuel to the micro-mixer fuel nozzles. The fuel injection system may include a center hub for providing the flow of fuel therethrough. The center hub may include a first supply circuit for a first micro-mixer fuel nozzle and a second supply circuit for a second micro-mixer fuel nozzle.

Novel method for dynamic control of intracranial pressure.

PubMed

Luciano, Mark G; Dombrowski, Stephen M; Qvarlander, Sara; El-Khoury, Serge; Yang, Jun; Thyagaraj, Suraj; Loth, Francis

2017-05-01

OBJECT Intracranial pressure (ICP) pulsations are generally considered a passive result of the pulsatility of blood flow. Active experimental modification of ICP pulsations would allow investigation of potential active effects on blood and CSF flow and potentially create a new platform for the treatment of acute and chronic low blood flow states as well as a method of CSF substance clearance and delivery. This study presents a novel method and device for altering the ICP waveform via cardiac-gated volume changes. METHODS The novel device used in this experiment (named Cadence) consists of a small air-filled inelastic balloon (approximately 1.0 ml) implanted into the intracranial space and connected to an external programmable pump, triggered by an R-wave detector. Balloons were implanted into the epidural space above 1 of the hemispheres of 19 canines for up to 10 hours. When activated, the balloons were programed to cyclically inflate with the cardiac cycle with variable delay, phase, and volume. The ICP response was measured in both hemispheres. Additionally, cerebral blood flow (heat diffusion and laser Doppler) was studied in 16 canines. RESULTS This system, depending on the inflation pattern of the balloon, allowed a flattening of the ICP waveform, increase in the ICP waveform amplitude, or phase shift of the wave. This occurred with small mean ICP changes, typically around ± 2 mm Hg (15%). Bilateral ICP effects were observed with activation of the device: balloon inflation at each systole increased the systolic ICP pulse (up to 16 mm Hg, 1200%) and deflation at systole decreased or even inverted the systolic ICP pulse (-0.5 to -19 mm Hg, -5% to -1600%) in a dose-(balloon volume) dependent fashion. No aphysiological or deleterious effects on systemic pressure (≤ ±10 mm Hg; 13% change in mean pressure) or cardiac rate (≤ ± 17 beats per minute; 16% change) were observed during up to 4 hours of balloon activity. CONCLUSIONS The results of these initial studies using an intracranially implanted, cardiac-gated, volume-oscillating balloon suggest the Cadence device can be used to modify ICP pulsations, without physiologically deleterious effects on mean ICP, systemic vascular effects, or brain injury. This device and technique may be used to study the role of ICP pulsatility in intracranial hemo- and hydrodynamic processes and introduces the creation of a potential platform of a cardiac-gated system for treatment of acute and chronic low blood flow states, and diseases requiring augmentation of CSF substance clearance or delivery.

The Advantages of Non-Flow-Through Fuel Cell Power Systems for Aerospace Applications

NASA Technical Reports Server (NTRS)

Hoberecht, Mark; Burke, Kenneth; Jakupca, Ian

2011-01-01

NASA has been developing proton-exchange-membrane (PEM) fuel cell power systems for the past decade, as an upgraded technology to the alkaline fuel cells which presently provide power for the Shuttle Orbiter. All fuel cell power systems consist of one or more fuel cell stacks in combination with appropriate balance-of-plant hardware. Traditional PEM fuel cells are characterized as flow-through, in which recirculating reactant streams remove product water from the fuel cell stack. NASA recently embarked on the development of non-flow-through fuel cell systems, in which reactants are dead-ended into the fuel cell stack and product water is removed by internal wicks. This simplifies the fuel cell power system by eliminating the need for pumps to provide reactant circulation, and mechanical water separators to remove the product water from the recirculating reactant streams. By eliminating these mechanical components, the resulting fuel cell power system has lower mass, volume, and parasitic power requirements, along with higher reliability and longer life. These improved non-flow-through fuel cell power systems therefore offer significant advantages for many aerospace applications.

A numerical study of blood flow using mixture theory

PubMed Central

Wu, Wei-Tao; Aubry, Nadine; Massoudi, Mehrdad; Kim, Jeongho; Antaki, James F.

2014-01-01

In this paper, we consider the two dimensional flow of blood in a rectangular microfluidic channel. We use Mixture Theory to treat this problem as a two-component system: One component is the red blood cells (RBCs) modeled as a generalized Reiner–Rivlin type fluid, which considers the effects of volume fraction (hematocrit) and influence of shear rate upon viscosity. The other component, plasma, is assumed to behave as a linear viscous fluid. A CFD solver based on OpenFOAM® was developed and employed to simulate a specific problem, namely blood flow in a two dimensional micro-channel, is studied. Finally to better understand this two-component flow system and the effects of the different parameters, the equations are made dimensionless and a parametric study is performed. PMID:24791016

A numerical study of blood flow using mixture theory.

PubMed

Wu, Wei-Tao; Aubry, Nadine; Massoudi, Mehrdad; Kim, Jeongho; Antaki, James F

2014-03-01

In this paper, we consider the two dimensional flow of blood in a rectangular microfluidic channel. We use Mixture Theory to treat this problem as a two-component system: One component is the red blood cells (RBCs) modeled as a generalized Reiner-Rivlin type fluid, which considers the effects of volume fraction (hematocrit) and influence of shear rate upon viscosity. The other component, plasma, is assumed to behave as a linear viscous fluid. A CFD solver based on OpenFOAM ® was developed and employed to simulate a specific problem, namely blood flow in a two dimensional micro-channel, is studied. Finally to better understand this two-component flow system and the effects of the different parameters, the equations are made dimensionless and a parametric study is performed.

Colony Rheology: Active Arthropods Generate Flows

NASA Astrophysics Data System (ADS)

Daniels, Karen; Mann, Michael; Charbonneau, Patrick

2015-03-01

Hydrodynamic-like flows are observed in biological systems as varied as bacteria, insects, birds, fish, and mammals. Both the phenomenology (e.g. front instabilities, milling motions) and the interaction types (hydrodynamic, direct contact, psychological, excluded-volume) strongly vary between systems, but a question common to all of them is to understand the role of particle-scale fluctuations in controlling large-scale rheological behaviors. We will address these questions through experiments on a new system, Tyrolichus casei (cheese mites), which live in dense, self-mixing colonies composed of a mixture of living mites and inert flour/detritus. In experiments performed in a Hele-Shaw geometry, we observe that the rheology of a colony is strongly dependent on the relative concentration of active and inactive particles. In addition to spreading flows, we also observe that the system can generate convective circulation and auto-compaction.

Microfluidic chemostat and turbidostat with flow rate, oxygen, and temperature control for dynamic continuous culture.

PubMed

Lee, Kevin S; Boccazzi, Paolo; Sinskey, Anthony J; Ram, Rajeev J

2011-05-21

This work reports on an instrument capable of supporting automated microscale continuous culture experiments. The instrument consists of a plastic-PDMS device capable of continuous flow without volume drift or evaporation. We apply direct computer controlled machining and chemical bonding fabrication for production of fluidic devices with a 1 mL working volume, high oxygen transfer rate (k(L)a≈0.025 s(-1)), fast mixing (2 s), accurate flow control (±18 nL), and closed loop control over temperature, cell density, dissolved oxygen, and pH. Integrated peristaltic pumps and valves provide control over input concentrations and allow the system to perform different types of cell culture on a single device, such as batch, chemostat, and turbidostat continuous cultures. Continuous cultures are demonstrated without contamination for 3 weeks in a single device and both steady state and dynamically controlled conditions are possible. © The Royal Society of Chemistry 2011

Design verification and cold-flow modeling test report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1993-07-01

This report presents a compilation of the following three test reports prepared by TRW for Alaska Industrial Development and Export Authority (AIDEA) as part of the Healy Clean Coal Project, Phase 1 Design of the TRW Combustor and Auxiliary Systems, which is co-sponsored by the Department of Energy under the Clean Coal Technology 3 Program: (1) Design Verification Test Report, dated April 1993, (2) Combustor Cold Flow Model Report, dated August 28, 1992, (3) Coal Feed System Cold Flow Model Report, October 28, 1992. In this compilation, these three reports are included in one volume consisting of three parts, andmore » TRW proprietary information has been excluded.« less

Empirical models for predicting volumes of sediment deposited by debris flows and sediment-laden floods in the transverse ranges of southern California

USGS Publications Warehouse

Gartner, Joseph E.; Cannon, Susan H.; Santi, Paul M

2014-01-01

Debris flows and sediment-laden floods in the Transverse Ranges of southern California pose severe hazards to nearby communities and infrastructure. Frequent wildfires denude hillslopes and increase the likelihood of these hazardous events. Debris-retention basins protect communities and infrastructure from the impacts of debris flows and sediment-laden floods and also provide critical data for volumes of sediment deposited at watershed outlets. In this study, we supplement existing data for the volumes of sediment deposited at watershed outlets with newly acquired data to develop new empirical models for predicting volumes of sediment produced by watersheds located in the Transverse Ranges of southern California. The sediment volume data represent a broad sample of conditions found in Ventura, Los Angeles and San Bernardino Counties, California. The measured volumes of sediment, watershed morphology, distributions of burn severity within each watershed, the time since the most recent fire, triggering storm rainfall conditions, and engineering soil properties were analyzed using multiple linear regressions to develop two models. A “long-term model” was developed for predicting volumes of sediment deposited by both debris flows and floods at various times since the most recent fire from a database of volumes of sediment deposited by a combination of debris flows and sediment-laden floods with no time limit since the most recent fire (n = 344). A subset of this database was used to develop an “emergency assessment model” for predicting volumes of sediment deposited by debris flows within two years of a fire (n = 92). Prior to developing the models, 32 volumes of sediment, and related parameters for watershed morphology, burn severity and rainfall conditions were retained to independently validate the long-term model. Ten of these volumes of sediment were deposited by debris flows within two years of a fire and were used to validate the emergency assessment model. The models were validated by comparing predicted and measured volumes of sediment. These validations were also performed for previously developed models and identify that the models developed here best predict volumes of sediment for burned watersheds in comparison to previously developed models.

A depth-averaged debris-flow model that includes the effects of evolving dilatancy: II. Numerical predictions and experimental tests.

USGS Publications Warehouse

George, David L.; Iverson, Richard M.

2014-01-01

We evaluate a new depth-averaged mathematical model that is designed to simulate all stages of debris-flow motion, from initiation to deposition. A companion paper shows how the model’s five governing equations describe simultaneous evolution of flow thickness, solid volume fraction, basal pore-fluid pressure, and two components of flow momentum. Each equation contains a source term that represents the influence of state-dependent granular dilatancy. Here we recapitulate the equations and analyze their eigenstructure to show that they form a hyperbolic system with desirable stability properties. To solve the equations we use a shock-capturing numerical scheme with adaptive mesh refinement, implemented in an open-source software package we call D-Claw. As tests of D-Claw, we compare model output with results from two sets of large-scale debris-flow experiments. One set focuses on flow initiation from landslides triggered by rising pore-water pressures, and the other focuses on downstream flow dynamics, runout, and deposition. D-Claw performs well in predicting evolution of flow speeds, thicknesses, and basal pore-fluid pressures measured in each type of experiment. Computational results illustrate the critical role of dilatancy in linking coevolution of the solid volume fraction and pore-fluid pressure, which mediates basal Coulomb friction and thereby regulates debris-flow dynamics.

Geometric optimization of thermal systems

NASA Astrophysics Data System (ADS)

Alebrahim, Asad Mansour

2000-10-01

The work in chapter 1 extends to three dimensions and to convective heat transfer the constructal method of minimizing the thermal resistance between a volume and one point. In the first part, the heat flow mechanism is conduction, and the heat generating volume is occupied by low conductivity material (k 0) and high conductivity inserts (kp) that are shaped as constant-thickness disks mounted on a common stem of kp material. In the second part the interstitial spaces once occupied by k0 material are bathed by forced convection. The internal and external geometric aspect ratios of the elemental volume and the first assembly are optimized numerically subject to volume constraints. Chapter 2 presents the constrained thermodynamic optimization of a cross-flow heat exchanger with ram air on the cold side, which is used in the environmental control systems of aircraft. Optimized geometric features such as the ratio of channel spacings and flow lengths are reported. It is found that the optimized features are relatively insensitive to changes in other physical parameters of the installation and relatively insensitive to the additional irreversibility due to discharging the ram-air stream into the atmosphere, emphasizing the robustness of the thermodynamic optimum. In chapter 3 the problem of maximizing exergy extraction from a hot stream by distributing streams over a heat transfer surface is studied. In the first part, the cold stream is compressed in an isothermal compressor, expanded in an adiabatic turbine, and discharged into the ambient. In the second part, the cold stream is compressed in an adiabatic compressor. Both designs are optimized with respect to the capacity-rate imbalance of the counter-flow and the pressure ratio maintained by the compressor. This study shows the tradeoff between simplicity and increased performance, and outlines the path for further conceptual work on the extraction of exergy from a hot stream that is being cooled gradually. The aim of chapter 4 was to optimize the performance of a boot-strap air cycle of an environmental control system (ECS) for aircraft. New in the present study was that the optimization refers to the performance of the entire ECS system, not to the performance of an individual component. Also, there were two heat exchangers, not one, and their relative positions and sizes were not specified in advance. This study showed that geometric optimization can be identified when the optimization procedure refers to the performance of the entire ECS system, not to the performance of an individual component. This optimized features were robust relative to some physical parameters. This robustness may be used to simplify future optimization of similar systems.

Solderability test system

DOEpatents

Yost, Fred; Hosking, Floyd M.; Jellison, James L.; Short, Bruce; Giversen, Terri; Reed, Jimmy R.

1998-01-01

A new test method to quantify capillary flow solderability on a printed wiring board surface finish. The test is based on solder flow from a pad onto narrow strips or lines. A test procedure and video image analysis technique were developed for conducting the test and evaluating the data. Feasibility tests revealed that the wetted distance was sensitive to the ratio of pad radius to line width (l/r), solder volume, and flux predry time.

On the structure of viscous flow about the afterbody of hull

NASA Astrophysics Data System (ADS)

Yoshida, Osamu; Zhu, Ming; Miyata, Hideaki

1993-09-01

A finite-volume method is applied to a flow about full ship models in the curvilinear coordinate system. Simulations are carried out for SR196 frame-line series. The simulated results show the difference of the wake and the longitudinal vorticity between the different hull forms. The comparisons between simulated and measured results show qualitative agreements in the wake distributions near the propeller disk circumference.

Numerical simulation of helicopter engine plume in forward flight

NASA Technical Reports Server (NTRS)

Dimanlig, Arsenio C. B.; Vandam, Cornelis P.; Duque, Earl P. N.

1994-01-01

Flowfields around helicopters contain complex flow features such as large separated flow regions, vortices, shear layers, blown and suction surfaces and an inherently unsteady flow imposed by the rotor system. Another complicated feature of helicopters is their infrared signature. Typically, the aircraft's exhaust plume interacts with the rotor downwash, the fuselage's complicated flowfield, and the fuselage itself giving each aircraft a unique IR signature at given flight conditions. The goal of this project was to compute the flow about a realistic helicopter fuselage including the interaction of the engine air intakes and exhaust plume. The computations solve the Think-Layer Navier Stokes equations using overset type grids and in particular use the OVERFLOW code by Buning of NASA Ames. During this three month effort, an existing grid system of the Comanche Helicopter was to be modified to include the engine inlet and the hot engine exhaust. The engine exhaust was to be modeled as hot air exhaust. However, considerable changes in the fuselage geometry required a complete regriding of the surface and volume grids. The engine plume computations have been delayed to future efforts. The results of the current work consists of a complete regeneration of the surface and volume grids of the most recent Comanche fuselage along with a flowfield computation.

ANALYSIS OF FLOW-STRUCTURE COUPLING IN A MECHANICAL MODEL OF THE VOCAL FOLDS AND THE SUBGLOTTAL SYSTEM.

PubMed

Howe, M S; McGowan, R S

2009-11-01

An analysis is made of the nonlinear interactions between flow in the subglottal vocal tract and glottis, sound waves in the subglottal system and a mechanical model of the vocal folds. The mean flow through the system is produced by a nominally steady contraction of the lungs, and mechanical experiments frequently involve a 'lung cavity' coupled to an experimental subglottal tube of arbitrary or ill-defined effective length L, on the basis that the actual value of L has little or no influence on excitation of the vocal folds. A simple, self-exciting single mass mathematical model of the vocal folds is used to investigate the sound generated within the subglottal domain and the unsteady volume flux from the glottis for experiments where it is required to suppress feedback of sound from the supraglottal vocal tract. In experiments where the assumed absorption of sound within the sponge-like interior of the lungs is small, the influence of changes in L can be very significant: when the subglottal tube behaves as an open-ended resonator (when L is as large as half the acoustic wavelength) there is predicted to be a mild increase in volume flux magnitude and a small change in waveform. However, the strong appearance of second harmonics of the acoustic field is predicted at intermediate lengths, when L is roughly one quarter of the acoustic wavelength. In cases of large lung damping, however, only modest changes in the volume flux are predicted to occur with variations in L.

Comparative analysis for various redox flow batteries chemistries using a cost performance model

NASA Astrophysics Data System (ADS)

Crawford, Alasdair; Viswanathan, Vilayanur; Stephenson, David; Wang, Wei; Thomsen, Edwin; Reed, David; Li, Bin; Balducci, Patrick; Kintner-Meyer, Michael; Sprenkle, Vincent

2015-10-01

The total energy storage system cost is determined by means of a robust performance-based cost model for multiple flow battery chemistries. Systems aspects such as shunt current losses, pumping losses and various flow patterns through electrodes are accounted for. The system cost minimizing objective function determines stack design by optimizing the state of charge operating range, along with current density and current-normalized flow. The model cost estimates are validated using 2-kW stack performance data for the same size electrodes and operating conditions. Using our validated tool, it has been demonstrated that an optimized all-vanadium system has an estimated system cost of < 350 kWh-1 for 4-h application. With an anticipated decrease in component costs facilitated by economies of scale from larger production volumes, coupled with performance improvements enabled by technology development, the system cost is expected to decrease to 160 kWh-1 for a 4-h application, and to 100 kWh-1 for a 10-h application. This tool has been shared with the redox flow battery community to enable cost estimation using their stack data and guide future direction.

Rheoencephalographic (REG) Assessment of Head and Neck Cooling for use with Multiple Sclerosis Patients

NASA Technical Reports Server (NTRS)

Montogomery, Leslie D.; Ku, Yu-Tsuan E.; Webbon, Bruce W. (Technical Monitor)

1995-01-01

We have prepared a computer program (RHEOSYS:RHEOencephalographic impedance trace scanning SyStem) that can be used to automate the analysis of segmental impedance blood flow waveforms. This program was developed to assist in the post test analysis of recorded impedance traces from multiple segments of the body. It incorporates many of the blood flow, segmental volume, and vascular state indices reported in the world literature. As it is currently programmed, seven points are selected from each blood flow pulse and associated ECG waveforrn: 1. peak of the first ECG QRS complex, 2. start of systolic slope on the blood flow trace, 3. maximum amplitude of the impedance pulse, 4. position of the dicrotic notch, 5. maximum amplitude of the postdicrotic segment, 6. peak of the second ECG QRS complex, and 7. start of the next blood flow pulse. These points we used to calculate various geometric, area, and time-related values associated with the impedance pulse morphology. RHEOSYS then calculates a series of 34 impedance and cardiac cycle parameters which include pulse amplitudes; areas; pulse propagation times; cardiac cycle times; and various measures of arterial and various tone, contractility, and pulse volume. We used this program to calculate the scalp and intracranial blood flow responses to head and neck cooling as it may be applied to lower the body temperatures of multiple sclerosis patients. Twelve women and twelve men were tested using a commercially available head and neck cooling system operated at its maximum cooling capacity for a period of 30 minutes. Head and neck cooling produced a transient change in scalp blood flow and a significant, (P<0.05) decrease of approx. 30% in intracranial blood flow. Results of this experiment will illustrate how REG and RHEOSYS can be used in biomedical applications.

Investigation of supersonic chemically reacting and radiating channel flow

NASA Technical Reports Server (NTRS)

Mani, Mortaza; Tiwari, Surendra N.

1988-01-01

The 2-D time-dependent Navier-Stokes equations are used to investigate supersonic flows undergoing finite rate chemical reaction and radiation interaction for a hydrogen-air system. The explicit multistage finite volume technique of Jameson is used to advance the governing equations in time until convergence is achieved. The chemistry source term in the species equation is treated implicitly to alleviate the stiffness associated with fast reactions. The multidimensional radiative transfer equations for a nongray model are provided for a general configuration and then reduced for a planar geometry. Both pseudo-gray and nongray models are used to represent the absorption-emission characteristics of the participating species. The supersonic inviscid and viscous, nonreacting flows are solved by employing the finite volume technique of Jameson and the unsplit finite difference scheme of MacCormack. The specified problem considered is of the flow in a channel with a 10 deg compression-expansion ramp. The calculated results are compared with those of an upwind scheme. The problem of chemically reacting and radiating flows are solved for the flow of premixed hydrogen-air through a channel with parallel boundaries, and a channel with a compression corner. Results obtained for specific conditions indicate that the radiative interaction can have a significant influence on the entire flow field.

Alveolar Tidal recruitment/derecruitment and Overdistension During Four Levels of End-Expiratory Pressure with Protective Tidal Volume During Anesthesia in a Murine Lung-Healthy Model.

PubMed

Soares, Joao Henrique Neves; Carvalho, Alysson Roncally; Bergamini, Bruno Curty; Gress, Maria Alice Kuster; Jandre, Frederico Caetano; Zin, Walter Araujo; Giannella-Neto, Antonio

2018-06-01

We compared respiratory mechanics between the positive end-expiratory pressure of minimal respiratory system elastance (PEEP minErs ) and three levels of PEEP during low-tidal-volume (6 mL/kg) ventilation in rats. Twenty-four rats were anesthetized, paralyzed, and mechanically ventilated. Airway pressure (P aw ), flow (F), and volume (V) were fitted by a linear single compartment model (LSCM) P aw (t) = E rs  × V(t) + R rs  × F(t) + PEEP or a volume- and flow-dependent SCM (VFDSCM) P aw (t) = (E 1  + E 2  × V(t)) × V(t) + (K 1  + K 2  × |F(t)|) × F(t) + PEEP, where E rs and R rs are respiratory system elastance and resistance, respectively; E 1 and E 2 × V are volume-independent and volume-dependent E rs , respectively; and K 1 and K 2  × F are flow-independent and flow-dependent R rs , respectively. Animals were ventilated for 1 h at PEEP 0 cmH 2 O (ZEEP); PEEP minErs ; 2 cmH 2 O above PEEP minErs (PEEP minErs+2 ); or 4 cmH 2 O above PEEP minErs (PEEP minErs+4 ). Alveolar tidal recruitment/derecruitment and overdistension were assessed by the index %E 2  = 100 × [(E 2  × V T )/(E 1  + |E 2 | × V T )], and alveolar stability by the slope of E rs (t). %E 2 varied between 0 and 30% at PEEP minErs in most respiratory cycles. Alveolar Tidal recruitment/derecruitment (%E 2  < 0) and overdistension (%E 2  > 30) were predominant in the absence of PEEP and in PEEP levels higher than PEEP minErs , respectively. The slope of E rs (t) was different from zero in all groups besides PEEP minErs+4 . PEEP minErs presented the best compromise between alveolar tidal recruitment/derecruitment and overdistension, during 1 h of low-V T mechanical ventilation.

Decrease of pulmonary blood flow detected by phase contrast MRI is correlated with a decrease in lung volume and increase of lung fibrosis area determined by computed tomography in interstitial lung disease.

PubMed

Tsuchiya, Nanae; Yamashiro, Tsuneo; Murayama, Sadayuki

2016-09-01

Lung volume and pulmonary blood flow decrease in patients with interstitial lung disease (ILD). The purpose of this study was to assess the relationship between pulmonary blood flow and lung volume in ILD patients. This research was approved by the institutional review board. Twenty-seven patients (9 men, 18 women; mean age, 59 years; range, 24-79 years) with ILD were included. Blood flow was assessed in the pulmonary trunk and the left and right pulmonary arteries by phase contrast magnetic resonance imaging (MRI). Lung volume and the computed tomography (CT) visual score that indicates the severity of ILD were assessed on the left and right sides by thin-section CT scanning. Lung volume was automatically measured by lung analysis software (VINCENT Ver. 4). The CT visual score was measured by averaging the proportion of abnormal lung area at five anatomic levels. Pearson's correlation coefficient was used to determine the relationship between pulmonary blood flow and lung volume. Pulmonary blood flow showed a significant correlation with lung volume (both: r=0.52, p=0.006; left: r=0.61, p=0.001; right: r=0.54, p=0.004) and CT visual score (both: r=-0.39, p=0.04; left: r=-0.48, p=0.01; right: r=-0.38, p=0.04). Partial correlation analysis, controlled for age, height and weight, showed a significant correlation between pulmonary blood flow and lung volume (both: r=0.43, p=0.03; left: r=0.55, p=0.005; right: r=0.48, p=0.01) and CT visual score (both: r=-0.58, p=0.003; left: r=-0.51, p=0.01; right: r=-0.64, p=0.001). In ILD, reduced pulmonary blood flow is associated with reduced lung volume and increased abnormal lung area. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Are There Infinite Irrigation Trees?

NASA Astrophysics Data System (ADS)

Bernot, M.; Caselles, V.; Morel, J. M.

2006-08-01

In many natural or artificial flow systems, a fluid flow network succeeds in irrigating every point of a volume from a source. Examples are the blood vessels, the bronchial tree and many irrigation and draining systems. Such systems have raised recently a lot of interest and some attempts have been made to formalize their description, as a finite tree of tubes, and their scaling laws [25], [26]. In contrast, several mathematical models [5], [22], [10], propose an idealization of these irrigation trees, where a countable set of tubes irrigates any point of a volume with positive Lebesgue measure. There is no geometric obstruction to this infinitesimal model and general existence and structure theorems have been proved. As we show, there may instead be an energetic obstruction. Under Poiseuille law R(s) = s -2 for the resistance of tubes with section s, the dissipated power of a volume irrigating tree cannot be finite. In other terms, infinite irrigation trees seem to be impossible from the fluid mechanics viewpoint. This also implies that the usual principle analysis performed for the biological models needs not to impose a minimal size for the tubes of an irrigating tree; the existence of the minimal size can be proven from the only two obvious conditions for such irrigation trees, namely the Kirchhoff and Poiseuille laws.

Impacts of signal system timings on rain related congestion.

DOT National Transportation Integrated Search

2010-06-01

It is known that inclement weather can affect traffic volumes, vehicle speeds, speed variance, saturation flow rates, and sometimes : discharge rates from traffic signals. These parameters in turn can have a significant impact on the efficiency of tr...

Flow restrictor silicon membrane microvalve actuated by optically controlled paraffin phase transition

NASA Astrophysics Data System (ADS)

Kolari, K.; Havia, T.; Stuns, I.; Hjort, K.

2014-08-01

Restrictor valves allow proportional control of fluid flow but are rarely integrated in microfluidic systems. In this study, an optically actuated silicon membrane restrictor microvalve is demonstrated. Its actuation is based on the phase transition of paraffin, using a paraffin wax mixed with a suitable concentration of optically absorbing nanographite particles. Backing up the membrane with oil (the melted paraffin) allows for a compliant yet strong contact to the valve seat, which enables handling of high pressures. At flow rates up to 30 µL min-1 and at a pressure of 2 bars, the valve can successfully be closed and control the flow level by restriction. The use of this paraffin composite as an adhesive layer sandwiched between the silicon valve and glass eases fabrication. This type of restrictor valve is best suited for high pressure, low volume flow silicon-based nanofluidic systems.

Multi-Component, Multi-Point Interferometric Rayleigh/Mie Doppler Velocimeter

NASA Technical Reports Server (NTRS)

Danehy, Paul M.; Lee, Joseph W.; Bivolaru, Daniel

2012-01-01

An interferometric Rayleigh scattering system was developed to enable the measurement of multiple, orthogonal velocity components at several points within very-high-speed or high-temperature flows. The velocity of a gaseous flow can be optically measured by sending laser light into the gas flow, and then measuring the scattered light signal that is returned from matter within the flow. Scattering can arise from either gas molecules within the flow itself, known as Rayleigh scattering, or from particles within the flow, known as Mie scattering. Measuring Mie scattering is the basis of all commercial laser Doppler and particle imaging velocimetry systems, but particle seeding is problematic when measuring high-speed and high-temperature flows. The velocimeter is designed to measure the Doppler shift from only Rayleigh scattering, and does not require, but can also measure, particles within the flow. The system combines a direct-view, large-optic interferometric setup that calculates the Doppler shift from fringe patterns collected with a digital camera, and a subsystem to capture and re-circulate scattered light to maximize signal density. By measuring two orthogonal components of the velocity at multiple positions in the flow volume, the accuracy and usefulness of the flow measurement increase significantly over single or nonorthogonal component approaches.

Viscoelastic behavior of lung and chest wall in dogs determined by flow interruption.

PubMed

Similowski, T; Levy, P; Corbeil, C; Albala, M; Pariente, R; Derenne, J P; Bates, J H; Jonson, B; Milic-Emili, J

1989-12-01

Pulmonary and chest wall mechanics were studied in six anesthetized paralyzed dogs, by use of the technique of rapid airway occlusion during constant flow inflation. Analysis of the pressure changes after flow interruption allowed us to partition the overall resistance of the lung (Rl) and chest wall (Rw) and total respiratory system (Rrs) into two components, one (Rinit) reflecting in the lung airway resistance (Raw), the other (delta R) reflecting primarily the viscoelastic properties of the pulmonary and chest wall tissues. The effects of varying inspiratory flow and inflation volume were interpreted in terms of frequency dependence of resistance, by using a spring-and-dashpot model previously proposed and substantiated by Bates et al. (Proc. 9th Annu. Conf. IEEE Med. Biol. Soc., 1987, vol. 3, p. 1802-1803). We observed that 1) Raw and Rw,init were nearly equal and small relative to Rl and Rw (both were unaffected by flow); 2) Rrs,init decreased slightly with increasing volume; 3) both delta Rl and delta Rw decreased with increasing flow and increased with increasing lung volume. These changes were manifestations of frequency dependence of delta R, as it is predicted by the model; 4) Rrs, Rl, and Rw followed the same trends as delta R. These results corroborate data previously reported in the literature with the use of different techniques to measure airways and pulmonary tissue resistances and confirm that the use of Rl to assess bronchial reactivity is problematic. The interrupter techniques provides a convenient way to obtain Raw values, as well as analogs of lung and chest wall tissue resistances in intact dogs.

Flow behaviour in normal and Meniere’s disease of endolymphatic fluid inside the inner ear

NASA Astrophysics Data System (ADS)

Paisal, Muhammad Sufyan Amir; Azmi Wahab, Muhamad; Taib, Ishkrizat; Mat Isa, Norasikin; Ramli, Yahaya; Seri, Suzairin Md; Darlis, Nofrizalidris; Osman, Kahar; Khudzari, Ahmad Zahran Md; Nordin, Normayati

2017-09-01

Meniere’s disease is a rare disorder that affects the inner ear which might be more severe if not treated. This is due to fluctuating pressure of the fluid in the endolymphatic sac and dysfunction of cochlea which causing the stretching of vestibular membrane. However, the pattern of the flow recirculation in endolymphatic region is still not fully understood. Thus, this study aims to investigate the correlation between the increasing volume of endolymphatic fluid and flow characteristics such as velocity, pressure and wall shear stress. Three dimensional model of simplified endolymphatic region is modeled using computer aided design (CAD) software and simulated using computational fluid dynamic (CFD) software. There are three different models are investigated; normal (N) model, Meniere’s disease model with less severity (M1) and Meniere’s disease model with high severity (M2). From the observed, the pressure drop between inlet and outlet of inner ear becomes decreases as the outlet pressure along with endolymphatic volume increases. However, constant flow rate imposed at the inlet of endolymphatic showing the lowest velocity. Flow recirculation near to endolymphatic region is occurred as the volume in endolympathic increases. Overall, high velocity is monitored near to cochlear duct, ductus reuniens and endolymphatic duct. Hence, these areas show high distributions of wall shear stress (WSS) that indicating a high probability of endolymphatic wall membrane dilation. Thus, more severe conditions of Meniere’s disease, more complex of flow characteristic is occurred. This phenomenon presenting high probability of rupture is predicted at the certain area in the anatomy of vestibular system.

Tendency to occupy a statistically dominant spatial state of the flow as a driving force for turbulent transition.

PubMed

Chekmarev, Sergei F

2013-03-01

The transition from laminar to turbulent fluid motion occurring at large Reynolds numbers is generally associated with the instability of the laminar flow. On the other hand, since the turbulent flow characteristically appears in the form of spatially localized structures (e.g., eddies) filling the flow field, a tendency to occupy such a structured state of the flow cannot be ruled out as a driving force for turbulent transition. To examine this possibility, we propose a simple analytical model that treats the flow as a collection of localized spatial structures, each of which consists of elementary cells in which the behavior of the particles (atoms or molecules) is uncorrelated. This allows us to introduce the Reynolds number, associating it with the ratio between the total phase volume for the system and that for the elementary cell. Using the principle of maximum entropy to calculate the most probable size distribution of the localized structures, we show that as the Reynolds number increases, the elementary cells group into the localized structures, which successfully explains turbulent transition and some other general properties of turbulent flows. An important feature of the present model is that a bridge between the spatial-statistical description of the flow and hydrodynamic equations is established. We show that the basic assumptions underlying the model, i.e., that the particles are indistinguishable and elementary volumes of phase space exist in which the state of the particles is uncertain, are involved in the derivation of the Navier-Stokes equation. Taking into account that the model captures essential features of turbulent flows, this suggests that the driving force for the turbulent transition is basically the same as in the present model, i.e., the tendency of the system to occupy a statistically dominant state plays a key role. The instability of the flow at high Reynolds numbers can then be a mechanism to initiate structural rearrangement of the flow to find this state.

Numerical simulation of flow and melting characteristics of seawater-ice crystals two-phase flow in inlet straight pipe of shell and tube heat exchanger of polar ship

NASA Astrophysics Data System (ADS)

Xu, Li; Huang, Chang-Xu; Huang, Zhen-Fei; Sun, Qiang; Li, Jie

2018-05-01

The ice crystal particles are easy to enter into the seawater cooling system of polar ship together with seawater when it sails in the Arctic. They are easy to accumulate in the pipeline, causing serious blockage of the cooling pipe. In this study, the flow and melting characteristics of ice particles-seawater two-phase flow in inlet straight pipe of shell-and-tube heat exchanger were numerically simulated by using Eulerian-Eulerian two-fluid model coupled with the interphase heat and mass transfer model. The influences of inlet ice packing factor, ice crystal particle diameter, and inlet velocity on the distribution and melting characteristics of ice crystals were investigated. The degree of asymmetry of the distribution of ice crystals in the cross section decreases gradually when the IPF changes from 5 to 15%. The volume fractions of ice crystals near the top of the outlet cross section are 19.59, 19.51, and 22.24% respectively for ice packing factor of 5, 10 and 15%. When the particle diameter is 0.5 mm, the ice crystals are gradually stratified during the flow process. With particle diameters of 1.0 and 2.0 mm, the region with the highest volume fraction of ice crystals is a small circle and the contours in the cloud map are compact. The greater the inlet flow velocity, the less stratified the ice crystals and the more obvious the turbulence on the outlet cross section. The average volume fraction of ice crystals along the flow direction is firstly rapidly reduced and then stabilized after 300 mm.

Traffic Vehicle Counting in Jam Flow Conditions Using Low-Cost and Energy-Efficient Wireless Magnetic Sensors.

PubMed

Bao, Xu; Li, Haijian; Xu, Dongwei; Jia, Limin; Ran, Bin; Rong, Jian

2016-11-06

The jam flow condition is one of the main traffic states in traffic flow theory and the most difficult state for sectional traffic information acquisition. Since traffic information acquisition is the basis for the application of an intelligent transportation system, research on traffic vehicle counting methods for the jam flow conditions has been worthwhile. A low-cost and energy-efficient type of multi-function wireless traffic magnetic sensor was designed and developed. Several advantages of the traffic magnetic sensor are that it is suitable for large-scale deployment and time-sustainable detection for traffic information acquisition. Based on the traffic magnetic sensor, a basic vehicle detection algorithm (DWVDA) with less computational complexity was introduced for vehicle counting in low traffic volume conditions. To improve the detection performance in jam flow conditions with a "tailgating effect" between front vehicles and rear vehicles, an improved vehicle detection algorithm (SA-DWVDA) was proposed and applied in field traffic environments. By deploying traffic magnetic sensor nodes in field traffic scenarios, two field experiments were conducted to test and verify the DWVDA and the SA-DWVDA algorithms. The experimental results have shown that both DWVDA and the SA-DWVDA algorithms yield a satisfactory performance in low traffic volume conditions (scenario I) and both of their mean absolute percent errors are less than 1% in this scenario. However, for jam flow conditions with heavy traffic volumes (scenario II), the SA-DWVDA was proven to achieve better results, and the mean absolute percent error of the SA-DWVDA is 2.54% with corresponding results of the DWVDA 7.07%. The results conclude that the proposed SA-DWVDA can implement efficient and accurate vehicle detection in jam flow conditions and can be employed in field traffic environments.

Traffic Vehicle Counting in Jam Flow Conditions Using Low-Cost and Energy-Efficient Wireless Magnetic Sensors

PubMed Central

Bao, Xu; Li, Haijian; Xu, Dongwei; Jia, Limin; Ran, Bin; Rong, Jian

2016-01-01

The jam flow condition is one of the main traffic states in traffic flow theory and the most difficult state for sectional traffic information acquisition. Since traffic information acquisition is the basis for the application of an intelligent transportation system, research on traffic vehicle counting methods for the jam flow conditions has been worthwhile. A low-cost and energy-efficient type of multi-function wireless traffic magnetic sensor was designed and developed. Several advantages of the traffic magnetic sensor are that it is suitable for large-scale deployment and time-sustainable detection for traffic information acquisition. Based on the traffic magnetic sensor, a basic vehicle detection algorithm (DWVDA) with less computational complexity was introduced for vehicle counting in low traffic volume conditions. To improve the detection performance in jam flow conditions with a “tailgating effect” between front vehicles and rear vehicles, an improved vehicle detection algorithm (SA-DWVDA) was proposed and applied in field traffic environments. By deploying traffic magnetic sensor nodes in field traffic scenarios, two field experiments were conducted to test and verify the DWVDA and the SA-DWVDA algorithms. The experimental results have shown that both DWVDA and the SA-DWVDA algorithms yield a satisfactory performance in low traffic volume conditions (scenario I) and both of their mean absolute percent errors are less than 1% in this scenario. However, for jam flow conditions with heavy traffic volumes (scenario II), the SA-DWVDA was proven to achieve better results, and the mean absolute percent error of the SA-DWVDA is 2.54% with corresponding results of the DWVDA 7.07%. The results conclude that the proposed SA-DWVDA can implement efficient and accurate vehicle detection in jam flow conditions and can be employed in field traffic environments. PMID:27827974

Method and apparatus for controlling fluid flow

DOEpatents

Miller, J.R.

1980-06-27

A method and apparatus for precisely controlling the rate (and hence amount) of fluid flow are given. The controlled flow rate is finely adjustable, can be extremely small (on the order of microliter-atmospheres per second), can be adjusted to zero (flow stopped), and is stable to better than 1% with time. The dead volume of the valve can be made arbitrarily small, in fact essentially zero. The valve employs no wearing mechanical parts (including springs, stems, or seals). The valve is finely adjustable, has a flow rate dynamic range of many decades, can be made compatible with any fluid, and is suitable for incorporation into an open or closed loop servo-control system.

SToRM: A numerical model for environmental surface flows

USGS Publications Warehouse

Simoes, Francisco J.

2009-01-01

SToRM (System for Transport and River Modeling) is a numerical model developed to simulate free surface flows in complex environmental domains. It is based on the depth-averaged St. Venant equations, which are discretized using unstructured upwind finite volume methods, and contains both steady and unsteady solution techniques. This article provides a brief description of the numerical approach selected to discretize the governing equations in space and time, including important aspects of solving natural environmental flows, such as the wetting and drying algorithm. The presentation is illustrated with several application examples, covering both laboratory and natural river flow cases, which show the model’s ability to solve complex flow phenomena.

Incorporation of Condensation Heat Transfer in a Flow Network Code

NASA Technical Reports Server (NTRS)

Anthony, Miranda; Majumdar, Alok; McConnaughey, Paul K. (Technical Monitor)

2001-01-01

In this paper we have investigated the condensation of water vapor in a short tube. A numerical model of condensation heat transfer was incorporated in a flow network code. The flow network code that we have used in this paper is Generalized Fluid System Simulation Program (GFSSP). GFSSP is a finite volume based flow network code. Four different condensation models were presented in the paper. Soliman's correlation has been found to be the most stable in low flow rates which is of particular interest in this application. Another highlight of this investigation is conjugate or coupled heat transfer between solid or fluid. This work was done in support of NASA's International Space Station program.

Shuttle cryogenic supply system optimization study. Volume 2: Technical report, sections 4 through 9

NASA Technical Reports Server (NTRS)

1973-01-01

The design and development of cryogenic supply systems for space shuttle vehicles are discussed. The weights, component counts, and statements of advantages and disadvantages of the systems considered are presented. Performance characteristics of the systems are analyzed in the form of graphs. Block diagrams and engineering drawings of the candidate systems are provided. Special consideration is given to flow rates and thermodynamic properties of the cryogenic systems.

Chamber for the optical manipulation of microscopic particles

DOEpatents

Buican, Tudor N.; Upham, Bryan D.

1992-01-01

A particle control chamber enables experiments to be carried out on biological cells and the like using a laser system to trap and manipulate the particles. A manipulation chamber provides a plurality of inlet and outlet ports for the particles and for fluids used to control or to contact the particles. A central manipulation area is optically accessible by the laser and includes first enlarged volumes for containing a selected number of particles for experimentation. A number of first enlarged volumes are connected by flow channels through second enlarged volumes. The second enlarged volumes act as bubble valves for controlling the interconnections between the first enlarged volumes. Electrode surfaces may be applied above the first enlarged volumes to enable experimentation using the application of electric fields within the first enlarged volumes. A variety of chemical and environmental conditions may be established within individual first enlarged volumes to enable experimental conditions for small scale cellular interactions.

Gravitational potential wells and the cosmic bulk flow

NASA Astrophysics Data System (ADS)

Wang, Yuyu; Kumar, Abhinav; Feldman, Hume; Watkins, Richard

2016-03-01

The bulk flow is a volume average of the peculiar velocities and a useful probe of the mass distribution on large scales. The gravitational instability model views the bulk flow as a potential flow that obeys a Maxwellian Distribution. We use two N-body simulations, the LasDamas Carmen and the Horizon Run, to calculate the bulk flows of various sized volumes in the simulation boxes. Once we have the bulk flow velocities as a function of scale, we investigate the mass and gravitational potential distribution around the volume. We found that matter densities can be asymmetrical and difficult to detect in real surveys, however, the gravitational potential and its gradient may provide better tools to investigate the underlying matter distribution. This study shows that bulk flows are indeed potential flows and thus provides information on the flow sources. We also show that bulk flow magnitudes follow a Maxwellian distribution on scales > 10h-1 Mpc.

System for creating on site, remote from a sterile environment, parenteral solutions

NASA Technical Reports Server (NTRS)

Finley, Mike (Inventor); Scharf, Mike (Inventor); Packard, Jeff (Inventor); Kipp, Jim (Inventor); Dudar, Tom (Inventor); Owens, Jim (Inventor); Bindokas, Al (Inventor)

1996-01-01

The present invention provides a system and method for creating on site, remote from a sterile environment, parenteral solutions in large volume parenteral containers for intravenous administration to a patient. In an embodiment, this system comprises an empty large volume container including at least one port for accessing an interior of the container. The port includes a sterilizing filter for sterilizing a fluid fed through the port into the container. A second container is provided including a solute and having means for coupling the second container to the large volume container and thereby providing fluid communication therebetween allowing the solute to be received within the interior of the container. A sterile water source is also provided including means for placing the sterile water source in fluid communication with the port and allowing water to flow from the sterile water source into the interior of the container. This allows the solute, and sterile water that has been fed through the filter, to create a parenteral solution in the large volume parenteral container.

COMMIX-PPC: A three-dimensional transient multicomponent computer program for analyzing performance of power plant condensers. Volume 1, Equations and numerics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chien, T.H.; Domanus, H.M.; Sha, W.T.

1993-02-01

The COMMIX-PPC computer pregrain is an extended and improved version of earlier COMMIX codes and is specifically designed for evaluating the thermal performance of power plant condensers. The COMMIX codes are general-purpose computer programs for the analysis of fluid flow and heat transfer in complex Industrial systems. In COMMIX-PPC, two major features have been added to previously published COMMIX codes. One feature is the incorporation of one-dimensional equations of conservation of mass, momentum, and energy on the tube stile and the proper accounting for the thermal interaction between shell and tube side through the porous-medium approach. The other added featuremore » is the extension of the three-dimensional conservation equations for shell-side flow to treat the flow of a multicomponent medium. COMMIX-PPC is designed to perform steady-state and transient. Three-dimensional analysis of fluid flow with heat transfer tn a power plant condenser. However, the code is designed in a generalized fashion so that, with some modification, it can be used to analyze processes in any heat exchanger or other single-phase engineering applications. Volume I (Equations and Numerics) of this report describes in detail the basic equations, formulation, solution procedures, and models for a phenomena. Volume II (User`s Guide and Manual) contains the input instruction, flow charts, sample problems, and descriptions of available options and boundary conditions.« less

Cardiovascular adaptations supporting human exercise-heat acclimation.

PubMed

Périard, Julien D; Travers, Gavin J S; Racinais, Sébastien; Sawka, Michael N

2016-04-01

This review examines the cardiovascular adaptations along with total body water and plasma volume adjustments that occur in parallel with improved heat loss responses during exercise-heat acclimation. The cardiovascular system is well recognized as an important contributor to exercise-heat acclimation that acts to minimize physiological strain, reduce the risk of serious heat illness and better sustain exercise capacity. The upright posture adopted by humans during most physical activities and the large skin surface area contribute to the circulatory and blood pressure regulation challenge of simultaneously supporting skeletal muscle blood flow and dissipating heat via increased skin blood flow and sweat secretion during exercise-heat stress. Although it was traditionally held that cardiac output increased during exercise-heat stress to primarily support elevated skin blood flow requirements, recent evidence suggests that temperature-sensitive mechanisms may also mediate an elevation in skeletal muscle blood flow. The cardiovascular adaptations supporting this challenge include an increase in total body water, plasma volume expansion, better sustainment and/or elevation of stroke volume, reduction in heart rate, improvement in ventricular filling and myocardial efficiency, and enhanced skin blood flow and sweating responses. The magnitude of these adaptations is variable and dependent on several factors such as exercise intensity, duration of exposure, frequency and total number of exposures, as well as the environmental conditions (i.e. dry or humid heat) in which acclimation occurs. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

End-expiratory lung volume and ventilation distribution with different continuous positive airway pressure systems in volunteers.

PubMed

Andersson, B; Lundin, S; Lindgren, S; Stenqvist, O; Odenstedt Hergès, H

2011-02-01

Continuous positive airway pressure (CPAP) has been shown to improve oxygenation and a number of different CPAP systems are available. The aim of this study was to assess lung volume and ventilation distribution using three different CPAP techniques. A high-flow CPAP system (HF-CPAP), an ejector-driven system (E-CPAP) and CPAP using a Servo 300 ventilator (V-CPAP) were randomly applied at 0, 5 and 10 cmH₂O in 14 volunteers. End-expiratory lung volume (EELV) was measured by N₂ dilution at baseline; changes in EELV and tidal volume distribution were assessed by electric impedance tomography. Higher end-expiratory and mean airway pressures were found using the E-CPAP vs. the HF-CPAP and the V-CPAP system (P<0.01). EELV increased markedly from baseline, 0 cmH₂O, with increased CPAP levels: 1110±380, 1620±520 and 1130±350 ml for HF-, E- and V-CPAP, respectively, at 10 cmH₂O. A larger fraction of the increase in EELV occurred for all systems in ventral compared with dorsal regions (P<0.01). In contrast, tidal ventilation was increasingly directed toward dorsal regions with increasing CPAP levels (P<0.01). The increase in EELV as well as the tidal volume redistribution were more pronounced with the E-CPAP system as compared with both the HF-CPAP and the V-CPAP systems (P<0.05) at 10 cmH₂O. EELV increased more in ventral regions with increasing CPAP levels, independent of systems, leading to a redistribution of tidal ventilation toward dorsal regions. Different CPAP systems resulted in different airway pressure profiles, which may result in different lung volume expansion and tidal volume distribution. © 2010 The Authors. Journal compilation © 2010 The Acta Anaesthesiologica Scandinavica Foundation.

Particle tracking velocimetry in three-dimensional flows

NASA Astrophysics Data System (ADS)

Maas, H. G.; Gruen, A.; Papantoniou, D.

1993-07-01

Particle Tracking Velocimetry (PTV) is a well-known technique for the determination of velocity vectors within an observation volume. However, for a long time it has rarely been applied because of the intensive effort necessary to measure coordinates of a large number of flow marker particles in many images. With today's imaging hardware in combination with the methods of digital image processing and digital photogrammetry, however, new possibilities have arisen for the design of completely automatic PTV systems. A powerful 3 D PTV has been developed in a cooperation of the Institute of Geodesy and Photogrammetry with the Institute of Hydromechanics and Water Resources Management at the Swiss Federal Institute of Technology. In this paper hardware components for 3 D PTV systems wil be discussed, and a strict mathematical model of photogrammetric 3 D coordinate determination, taking into account the different refractive indices in the optical path, will be presented. The system described is capable of determining coordinate sets of some 1000 particles in a flow field at a time resolution of 25 datasets per second and almost arbitrary sequence length completely automatically after an initialization by an operator. The strict mathematical modelling of the measurement geometry, together with a thorough calibration of the system provide for a coordinate accuracy of typically 0.06 mm in X, Y and 0.18 mm in Z (depth coordinate) in a volume of 200 × 160 × 50 mm3.

Concentric Split Flow Filter

NASA Technical Reports Server (NTRS)

Stapleton, Thomas J. (Inventor)

2015-01-01

A concentric split flow filter may be configured to remove odor and/or bacteria from pumped air used to collect urine and fecal waste products. For instance, filter may be designed to effectively fill the volume that was previously considered wasted surrounding the transport tube of a waste management system. The concentric split flow filter may be configured to split the air flow, with substantially half of the air flow to be treated traveling through a first bed of filter media and substantially the other half of the air flow to be treated traveling through the second bed of filter media. This split flow design reduces the air velocity by 50%. In this way, the pressure drop of filter may be reduced by as much as a factor of 4 as compare to the conventional design.

DSM-flux: A new technology for reliable Combined Sewer Overflow discharge monitoring with low uncertainties.

PubMed

Maté Marín, Ainhoa; Rivière, Nicolas; Lipeme Kouyi, Gislain

2018-06-01

In the past ten years, governments from the European Union have been encouraged to collect volume and quality data for all the effluent overflows from separated stormwater and combined sewer systems that result in a significant environmental impact on receiving water bodies. Methods to monitor and control these flows require improvements, particularly for complex Combined Sewer Overflow (CSO) structures. The DSM-flux (Device for Stormwater and combined sewer flows Monitoring and the control of pollutant fluxes) is a new pre-designed and pre-calibrated channel that provides appropriate hydraulic conditions suitable for measurement of overflow rates and volumes by means of one water level gauge. In this paper, a stage-discharge relation for the DSM-flux is obtained experimentally and validated for multiple inflow hydraulic configurations. Uncertainties in CSO discharges and volumes are estimated within the Guide to the expression of Uncertainty in Measurement (GUM) framework. Whatever the upstream hydraulic conditions are, relative uncertainties are lower than 15% and 2% for the investigated discharges and volumes, respectively. Copyright © 2018 Elsevier Ltd. All rights reserved.

Correlation of Apollo oxygen tank thermodynamic performance predictions

NASA Technical Reports Server (NTRS)

Patterson, H. W.

1971-01-01

Parameters necessary to analyze the stratified performance of the Apollo oxygen tanks include g levels, tank elasticity, flow rates and pressurized volumes. Methods for estimating g levels and flow rates from flight plans prior to flight, and from quidance and system data for use in the post flight analysis are described. Equilibrium thermodynamic equations are developed for the effects of tank elasticity and pressurized volumes on the tank pressure response and their relative magnitudes are discussed. Correlations of tank pressures and heater temperatures from flight data with the results of a stratification model are shown. Heater temperatures were also estimated with empirical heat transfer agreement with flight data when fluid properties were averaged rather than evaluated at the mean film temperature.

Transport and mixing of a volume of fluid in a complex geometry

NASA Astrophysics Data System (ADS)

Gavelli, Filippo

This work presents the results of the experimental investigation of an entire sequence of events, leading to an unwanted injection of boron-depleted water into the core of a PWR. The study is subdivided into three tasks: the generation of a dilute volume in the primary system, its transport to the core, and the mixing encountered along the path. Experiments conducted at the University of Maryland (UM) facility show that, during a Small-Break LOCA transient, volumes of dilute coolant are segregated in the system, by means of phase-separating energy transport from the core to the steam generators (Boiler Condenser Mode). Two motion-initiating mechanisms are considered: the resumption of natural circulation during the recovery of the primary liquid inventory, and the reactor coolant pump startup under BCM conditions. During the inventory recovery, various phenomena are observed, that contribute to the mixing of the dilute volumes prior to the resumption of flow. The pump activation, instead, occurs in a stagnant system, therefore, no mixing of the unborated liquid has occurred. Since an unmixed slug has the potential for a larger reactivity excursion than a partially mixed one, the pump-initiated flow resumption represents the worst-case scenario. The impulse - response method is applied, for the first time, to the problem of mixing in the downcomer. This allows to express the mixing in terms of two parameters, the dispersion number and the residence time, characteristics of the flow distribution in the complex annular geometry. Other important results are obtained from the analysis of the experimental data with this procedure. It is shown that the turbulence generated by the pump impeller has a significant impact on the overall mixing. Also, the geometric discontinuities in the downcomer (in particular, the gap enlargement below the cold leg elevation) are shown to be the cause of vortex structures that highly enhance the mixing process.

[Studies on a sequential injection renewable surface reflectance spectrophotometric system using a microchip flow cell].

PubMed

Wang, Jian-ya; Fang, Zhao-lun

2002-02-01

A microchip flow cell was developed for flow injection renewable surface assay by reflectance spectrophotometry. The flow cell was coupled to a sequential injection system and optical fiber photometric detection system. The flow cell featured a three-layer structure. The flow channel was cut into a silicone rubber membrance which formed the middle layer, and a porous filter was inlayed across a widened section of the channel to trap microbeads introduced into the flow cell. The area of the detection window of the flow cell was approximately 3.6 mm2, the volume of the bead trapped in the flow cell was 2.2 microL, the depth of the bead layer was 600 microns. A multistrand bifurcated optical fiber was coupled with incident light, detector and flow cell. The chromogenic reaction of Cr(VI) with 1,5-diphenylcarbohydrazide (DPC) which was adsorbed on trapped Polysorb C-18 beads was used as a model reaction to optimize the flow cell design and the experimental system. The reflectance of the renewable reaction surface was monitored at 540 nm. With 100 microL sample loaded and 1.0 mL.min-1 carrier flow rate, the linear response range was 0-0.6 microgram.mL-1 Cr(VI). A detection limit (3 sigma) of 6 ng.mL-1, precision of 1.5% RSD(n = 11), and a throughput of 64 samples per hour were achieved. Considerations in system and flow cell design, the influence of depth of the bead layer, weight of beads used, and the flow rates of carrier stream on the performance were discussed.

Automated flow quantification in valvular heart disease based on backscattered Doppler power analysis: implementation on matrix-array ultrasound imaging systems.

PubMed

Buck, Thomas; Hwang, Shawn M; Plicht, Björn; Mucci, Ronald A; Hunold, Peter; Erbel, Raimund; Levine, Robert A

2008-06-01

Cardiac ultrasound imaging systems are limited in the noninvasive quantification of valvular regurgitation due to indirect measurements and inaccurate hemodynamic assumptions. We recently demonstrated that the principle of integration of backscattered acoustic Doppler power times velocity can be used for flow quantification in valvular regurgitation directly at the vena contracta of a regurgitant flow jet. We now aimed to accomplish implementation of automated Doppler power flow analysis software on a standard cardiac ultrasound system utilizing novel matrix-array transducer technology with detailed description of system requirements, components and software contributing to the system. This system based on a 3.5 MHz, matrix-array cardiac ultrasound scanner (Sonos 5500, Philips Medical Systems) was validated by means of comprehensive experimental signal generator trials, in vitro flow phantom trials and in vivo testing in 48 patients with mitral regurgitation of different severity and etiology using magnetic resonance imaging (MRI) for reference. All measurements displayed good correlation to the reference values, indicating successful implementation of automated Doppler power flow analysis on a matrix-array ultrasound imaging system. Systematic underestimation of effective regurgitant orifice areas >0.65 cm(2) and volumes >40 ml was found due to currently limited Doppler beam width that could be readily overcome by the use of new generation 2D matrix-array technology. Automated flow quantification in valvular heart disease based on backscattered Doppler power can be fully implemented on board a routinely used matrix-array ultrasound imaging systems. Such automated Doppler power flow analysis of valvular regurgitant flow directly, noninvasively, and user independent overcomes the practical limitations of current techniques.

Regional Blood Volume and Peripheral Blood Flow in the Postural Tachycardia Syndrome

PubMed Central

Stewart, Julian M.; Montgomery, Leslie D.

2015-01-01

Variants of postural tachycardia syndrome (POTS) are associated with increased (“high flow” POTS, HFP), decreased (“low flow POTS”, LFP) and normal (“normal flow POTS”, NFP) blood flow measured in the lower extremities while supine. We propose that postural tachycardia is related to thoracic hypovolemia during orthostasis but that the patterns of peripheral blood flow relate to different mechanisms for thoracic hypovolemia. We studied 37 POTS patients aged 14-21 years: 14 LFP, 15 NFP and 8 HFP patients and 12 healthy control subjects. Peripheral blood flow was measured supine by venous occlusion strain gauge plethysmography of the forearm and calf in order to subgroup patients. Using indocyanine green techniques we showed decreased cardiac index (CI) and increased total peripheral resistance (TPR) in LFP, increased CI and decreased TPR in HFP, and unchanged CI and TPR in NFP while supine compared to control subjects. Blood volume tended to be decreased in LFP compared to control subjects. We used impedance plethysmography to assess regional blood volume redistribution during upright tilt. Thoracic blood volume decreased while splanchnic, pelvic and leg blood volumes increased for all subjects during orthostasis, but were markedly lower than control for all POTS groups. Splanchnic volume was increased in NFP and LFP. Pelvic blood volume was increased in HFP only. Calf volume was increased above control in HFP and LFP. The results support the hypothesis of [at least] three pathophysiologic variants of POTS distinguished by peripheral blood flow related to characteristic changes in regional circulations. The data demonstrate enhanced thoracic hypovolemia during upright tilt and confirm that POTS is related to inadequate cardiac venous return during orthostasis. PMID:15117717

A comparison of BNR activated sludge systems with membrane and settling tank solid-liquid separation.

PubMed

Ramphao, M C; Wentzel, M C; Ekama, G A; Alexander, W V

2006-01-01

Installing membranes for solid-liquid separation into biological nutrient removal (BNR) activated sludge (AS) systems makes a profound difference not only to the design of the membrane bio-reactor (MBR) BNR system itself, but also to the design approach for the whole wastewater treatment plant (WWTP). In multi-zone BNR systems with membranes in the aerobic reactor and fixed volumes for the anaerobic, anoxic and aerobic zones (i.e. fixed volume fractions), the mass fractions can be controlled (within a range) with the inter-reactor recycle ratios. This zone mass fraction flexibility is a significant advantage of MBR BNR systems over BNR systems with secondary settling tanks (SSTs), because it allows changing the mass fractions to optimise biological N and P removal in conformity with influent wastewater characteristics and the effluent N and P concentrations required. For PWWF/ADWF ratios (fq) in the upper range (fq approximately 2.0), aerobic mass fractions in the lower range (f(maer) < 0.60) and high (usually raw) wastewater strengths, the indicated mode of operation of MBR BNR systems is as extended aeration WWTPs (no primary settling and long sludge age). However, the volume reduction compared with equivalent BNR systems with SSTs will not be large (40-60%), but the cost of the membranes can be offset against sludge thickening and stabilisation costs. Moving from a flow unbalanced raw wastewater system to a flow balanced (fq = 1) low (usually settled) wastewater strength system can double the ADWF capacity of the biological reactor, but the design approach of the WWTP changes away from extended aeration to include primary sludge stabilisation. The cost of primary sludge treatment then has to be offset against the savings of the increased WWTP capacity.

Passenger flows in underground railway stations and platforms.

DOT National Transportation Integrated Search

2015-05-01

Urban rail systems are designed to carry large volumes of people into and out of major activity centers. As a result, the stations : at these major activity centers are often crowded with boarding and alighting passengers, resulting in passenger inco...

Development of decision support systems for real-time freeway traffic routing : volume II.

DOT National Transportation Integrated Search

1998-01-01

Real-time traffic flow routing is a promising approach to alleviating congestion. Existing approaches to developing real-time routing strategies, however, have limitations. This study explored the potential for using case-based reasoning (CBR), an em...

MRI-Based Computational Model of Heterogeneous Tracer Transport following Local Infusion into a Mouse Hind Limb Tumor

PubMed Central

Magdoom, Kulam Najmudeen; Pishko, Gregory L.; Rice, Lori; Pampo, Chris; Siemann, Dietmar W.; Sarntinoranont, Malisa

2014-01-01

Systemic drug delivery to solid tumors involving macromolecular therapeutic agents is challenging for many reasons. Amongst them is their chaotic microvasculature which often leads to inadequate and uneven uptake of the drug. Localized drug delivery can circumvent such obstacles and convection-enhanced delivery (CED) - controlled infusion of the drug directly into the tissue - has emerged as a promising delivery method for distributing macromolecules over larger tissue volumes. In this study, a three-dimensional MR image-based computational porous media transport model accounting for realistic anatomical geometry and tumor leakiness was developed for predicting the interstitial flow field and distribution of albumin tracer following CED into the hind-limb tumor (KHT sarcoma) in a mouse. Sensitivity of the model to changes in infusion flow rate, catheter placement and tissue hydraulic conductivity were investigated. The model predictions suggest that 1) tracer distribution is asymmetric due to heterogeneous porosity; 2) tracer distribution volume varies linearly with infusion volume within the whole leg, and exponentially within the tumor reaching a maximum steady-state value; 3) infusion at the center of the tumor with high flow rates leads to maximum tracer coverage in the tumor with minimal leakage outside; and 4) increasing the tissue hydraulic conductivity lowers the tumor interstitial fluid pressure and decreases the tracer distribution volume within the whole leg and tumor. The model thus predicts that the interstitial fluid flow and drug transport is sensitive to porosity and changes in extracellular space. This image-based model thus serves as a potential tool for exploring the effects of transport heterogeneity in tumors. PMID:24619021

Evaluation of Intersection Traffic Control Measures through Simulation

NASA Astrophysics Data System (ADS)

Asaithambi, Gowri; Sivanandan, R.

2015-12-01

Modeling traffic flow is stochastic in nature due to randomness in variables such as vehicle arrivals and speeds. Due to this and due to complex vehicular interactions and their manoeuvres, it is extremely difficult to model the traffic flow through analytical methods. To study this type of complex traffic system and vehicle interactions, simulation is considered as an effective tool. Application of homogeneous traffic models to heterogeneous traffic may not be able to capture the complex manoeuvres and interactions in such flows. Hence, a microscopic simulation model for heterogeneous traffic is developed using object oriented concepts. This simulation model acts as a tool for evaluating various control measures at signalized intersections. The present study focuses on the evaluation of Right Turn Lane (RTL) and Channelised Left Turn Lane (CLTL). A sensitivity analysis was performed to evaluate RTL and CLTL by varying the approach volumes, turn proportions and turn lane lengths. RTL is found to be advantageous only up to certain approach volumes and right-turn proportions, beyond which it is counter-productive. CLTL is found to be advantageous for lower approach volumes for all turn proportions, signifying the benefits of CLTL. It is counter-productive for higher approach volume and lower turn proportions. This study pinpoints the break-even points for various scenarios. The developed simulation model can be used as an appropriate intersection lane control tool for enhancing the efficiency of flow at intersections. This model can also be employed for scenario analysis and can be valuable to field traffic engineers in implementing vehicle-type based and lane-based traffic control measures.

Hydrologic modeling of two glaciated watersheds in Northeast Pennsylvania

USGS Publications Warehouse

Srinivasan, M.S.; Hamlett, J.M.; Day, R.L.; Sams, J.I.; Petersen, G.W.

1998-01-01

A hydrologic modeling study, using the Hydrologic Simulation Program - FORTRAN (HSPF), was conducted in two glaciated watersheds, Purdy Creek and Ariel Creek in northeastern Pennsylvania. Both watersheds have wetlands and poorly drained soils due to low hydraulic conductivity and presence of fragipans. The HSPF model was calibrated in the Purdy Creek watershed and verified in the Ariel Creek watershed for June 1992 to December 1993 period. In Purdy Creek, the total volume of observed streamflow during the entire simulation period was 13.36 x 106 m3 and the simulated streamflow volume was 13.82 x 106 m3 (5 percent difference). For the verification simulation in Ariel Creek, the difference between the total observed and simulated flow volumes was 17 percent. Simulated peak flow discharges were within two hours of the observed for 30 of 46 peak flow events (discharge greater than 0.1 m3/sec) in Purdy Creek and 27 of 53 events in Ariel Creek. For 22 of the 46 events in Purdy Creek and 24 of 53 in Ariel Creek, the differences between the observed and simulated peak discharge rates were less than 30 percent. These 22 events accounted for 63 percent of total volume of streamflow observed during the selected 46 peak flow events in Purdy Creek. In Ariel Creek, these 24 peak flow events accounted for 62 percent of the total flow observed during all peak flow events. Differences in observed and simulated peak flow rates and volumes (on a percent basis) were greater during the snowmelt runoff events and summer periods than for other times.A hydrologic modeling study, using the Hydrologic Simulation Program - FORTRAN (HSPF), was conducted in two glaciated watersheds, Purdy Creek and Ariel Creek in northeastern Pennsylvania. Both watersheds have wetlands and poorly drained soils due to low hydraulic conductivity and presence of fragipans. The HSPF model was calibrated in the Purdy Creek watershed and verified in the Ariel Creek watershed for June 1992 to December 1993 period. In Purdy Creek, the total volume of observed streamflow during the entire simulation period was 13.36??106 m3 and the simulated streamflow volume was 13.82??106 m3 (5 percent difference). For the verification simulation in Ariel Creek, the difference between the total observed and simulated flow volumes was 17 percent. Simulated peak flow discharges were within two hours of the observed for 30 of 46 peak flow events (discharge greater than 0.1 m3/sec) in Purdy Creek and 27 of 53 events in Ariel Creek. For 22 of the 46 events in Purdy Creek and 24 of 53 in Ariel Creek, the differences between the observed and simulated peak discharge rates were less than 30 percent. These 22 events accounted for 63 percent of total volume of streamflow observed during the selected 46 peak flow events in Purdy Creek. In Ariel Creek, these 24 peak flow events accounted for 62 percent of the total flow observed during all peak flow events. Differences in observed and simulated peak flow rates and volumes (on a percent basis) were greater during the snowmelt runoff events and summer periods than for other times.

TERSSE: Definition of the Total Earth Resources System for the Shuttle Era. Volume 3: Mission and System Requirements for the Total Earth Resources System

NASA Technical Reports Server (NTRS)

1974-01-01

Resource management missions to be performed by TERSSE are described. Mission and user requirements are defined along with information flows developed for each major resource management mission. Other topics discussed include: remote sensing platforms, remote sensor requirements, ground system architecture, and such related issues as cloud cover, resolution, orbit mechanics, and aircraft versus satellite.

Continuous-flow stirred-tank reactor 20-L demonstration test: Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, D.D.; Collins, J.L.

One of the proposed methods of removing the cesium, strontium, and transuranics from the radioactive waste storage tanks at Savannah River is the small-tank tetraphenylborate (TPB) precipitation process. A two-reactor-in-series (15-L working volume each) continuous-flow stirred-tank reactor (CSTR) system was designed, constructed, and installed in a hot cell to test the Savannah River process. The system also includes two cross-flow filtration systems to concentrate and wash the slurry produced in the process, which contains the bulk of radioactivity from the supernatant processed through the system. Installation, operational readiness reviews, and system preparation and testing were completed. The first test usingmore » the filtration systems, two CSTRs, and the slurry concentration system was conducted over a 61-h period with design removal of Cs, Sr, and U achieved. With the successful completion of Test 1a, the following tests, 1b and 1c, were not required.« less

Experimental and analytical investigation of a freezing point depressant fluid ice protection system. M.S. Thesis. Final Report

NASA Technical Reports Server (NTRS)

Albright, A. E.

1984-01-01

A glycol-exuding porous leading edge ice protection system was tested in the NASA Icing Research Tunnel. Stainless steel mesh, laser drilled titanium, and composite panels were tested on two general aviation wing sections. Two different glycol-water solutions were evaluated. Minimum glycol flow rates required for anti-icing were obtained as a function of angle of attack, liquid water content, volume median drop diameter, temperature, and velocity. Ice accretions formed after five minutes of icing were shed in three minutes or less using a glycol fluid flow equal to the anti-ice flow rate. Two methods of predicting anti-ice flow rates are presented and compared with a large experimental data base of anti-ice flow rates over a wide range of icing conditions. The first method presented in the ADS-4 document typically predicts flow rates lower than the experimental flow rates. The second method, originally published in 1983, typically predicts flow rates up to 25 percent higher than the experimental flow rates. This method proved to be more consistent between wing-panel configurations. Significant correlation coefficients between the predicted flow rates and the experimental flow rates ranged from .867 to .947.

Method and apparatus for continuous electrophoresis

DOEpatents

Watson, Jack S.

1992-01-01

A method and apparatus for conducting continuous separation of substances by electrophoresis are disclosed. The process involves electrophoretic separation combined with couette flow in a thin volume defined by opposing surfaces. By alternating the polarity of the applied potential and producing reciprocating short rotations of at least one of the surfaces relative to the other, small increments of separation accumulate to cause substantial, useful segregation of electrophoretically separable components in a continuous flow system.

Solderability test system

DOEpatents

Yost, F.; Hosking, F.M.; Jellison, J.L.; Short, B.; Giversen, T.; Reed, J.R.

1998-10-27

A new test method to quantify capillary flow solderability on a printed wiring board surface finish. The test is based on solder flow from a pad onto narrow strips or lines. A test procedure and video image analysis technique were developed for conducting the test and evaluating the data. Feasibility tests revealed that the wetted distance was sensitive to the ratio of pad radius to line width (l/r), solder volume, and flux predry time. 11 figs.

Walter Reed Army Medical Center, Washington, D. C. Annual Progress Report FY-89. Volume 2. Part 2

DTIC Science & Technology

1990-01-02

Patterns of Cerebral Blood Flow Determined by Iodoamphetamine SPECT in Sjogren’s Syndrome and Systemic Lupus Erythematosus: A Pilot Study KEYWORDS: SPECT...scanning in patients with Sjogren’s Syndrome and SLE. To identify possible regional defects in cerebral blood flow and correlate these defects with the...in animals reveals myelosuppression, lymphoid atrophy, * hemorrhagic enterocolitis, renal tubular necrosis, and cochlear damage, as well as some

Calibrating/testing meters in hot water test bench VM7

NASA Astrophysics Data System (ADS)

Kling, E.; Stolt, K.; Lau, P.; Mattiasson, K.

A Hot Water Test Bench, VM7, has been developed and constructed for the calibration and testing of volume and flowmeters, in a project at the National Volume Measurement Laboratory at the Swedish National Testing and Research Institute. The intended area of use includes use as a reference at audit measurements, e.g. for accredited laboratories, calibration of meters for the industry and for the testing of hot water meters. The objective of the project, which was initiated in 1989, was to design equipment with stable flow and with a minimal temperature drop even at very low flow rates. The principle of the design is a closed system with two pressure tanks at different pressures. The water is led from the high pressure tank through the test object and the volume standard, in the form of master meters or a piston prover alternatively, to the low pressure tank. Calibrations/tests are made comparing the indication of the test object to that of master meters covering the current flow rate. These are, in the same test cycle, calibrated to the piston prover. Alternatively, the test object can be calibrated directly to the piston prover.

PyFLOWGO: An open-source platform for simulation of channelized lava thermo-rheological properties

NASA Astrophysics Data System (ADS)

Chevrel, Magdalena Oryaëlle; Labroquère, Jérémie; Harris, Andrew J. L.; Rowland, Scott K.

2018-02-01

Lava flow advance can be modeled through tracking the evolution of the thermo-rheological properties of a control volume of lava as it cools and crystallizes. An example of such a model was conceived by Harris and Rowland (2001) who developed a 1-D model, FLOWGO, in which the velocity of a control volume flowing down a channel depends on rheological properties computed following the thermal path estimated via a heat balance box model. We provide here an updated version of FLOWGO written in Python that is an open-source, modern and flexible language. Our software, named PyFLOWGO, allows selection of heat fluxes and rheological models of the user's choice to simulate the thermo-rheological evolution of the lava control volume. We describe its architecture which offers more flexibility while reducing the risk of making error when changing models in comparison to the previous FLOWGO version. Three cases are tested using actual data from channel-fed lava flow systems and results are discussed in terms of model validation and convergence. PyFLOWGO is open-source and packaged in a Python library to be imported and reused in any Python program (https://github.com/pyflowgo/pyflowgo)

Nonlinear lymphangion pressure-volume relationship minimizes edema

PubMed Central

Venugopal, Arun M.; Stewart, Randolph H.; Laine, Glen A.

2010-01-01

Lymphangions, the segments of lymphatic vessel between two valves, contract cyclically and actively pump, analogous to cardiac ventricles. Besides having a discernable systole and diastole, lymphangions have a relatively linear end-systolic pressure-volume relationship (with slope Emax) and a nonlinear end-diastolic pressure-volume relationship (with slope Emin). To counter increased microvascular filtration (causing increased lymphatic inlet pressure), lymphangions must respond to modest increases in transmural pressure by increasing pumping. To counter venous hypertension (causing increased lymphatic inlet and outlet pressures), lymphangions must respond to potentially large increases in transmural pressure by maintaining lymph flow. We therefore hypothesized that the nonlinear lymphangion pressure-volume relationship allows transition from a transmural pressure-dependent stroke volume to a transmural pressure-independent stroke volume as transmural pressure increases. To test this hypothesis, we applied a mathematical model based on the time-varying elastance concept typically applied to ventricles (the ratio of pressure to volume cycles periodically from a minimum, Emin, to a maximum, Emax). This model predicted that lymphangions increase stroke volume and stroke work with transmural pressure if Emin < Emax at low transmural pressures, but maintain stroke volume and stroke work if Emin= Emax at higher transmural pressures. Furthermore, at higher transmural pressures, stroke work is evenly distributed among a chain of lymphangions. Model predictions were tested by comparison to previously reported data. Model predictions were consistent with reported lymphangion properties and pressure-flow relationships of entire lymphatic systems. The nonlinear lymphangion pressure-volume relationship therefore minimizes edema resulting from both increased microvascular filtration and venous hypertension. PMID:20601461

Experimental and Computational Investigation of Microbubble Production in Microfluidic Flow-Focusing Devices

NASA Astrophysics Data System (ADS)

Weber, Michael; Shandas, Robin

2005-11-01

Micron-sized bubbles have been effectively used as contrast agents in ultrasound imaging systems and have the potential for many other applications including targeted drug delivery and tumor destruction. The further development of these applications is dependent on precise control of bubble size. Recently, microfluidic flow-focusing systems have emerged as a viable means of producing microbubbles with monodisperse size distributions. These systems focus co-flowing liquid streams surrounding a gas stream through a narrow orifice, producing bubbles in very reproducible manner. In this work, a photopolymerization technique has been used to produce microfludicic flow-focusing devices which were successfully used to produce micron-sized bubbles. The flow dynamics involved in these devices has also been simulated using a volume-of-fluid approach to simultaneously solve the equations of motion for both the gas and liquid phases. Simulations were run with several variations of the flow-focuser geometry (gas inlet width, orifice length, gas-liquid approach angle, etc.) in an effort to produce smaller bubbles and increase the working range of liquid and gas flow rates. These findings are being incorporated into the production of actual devices in an effort to improve the overall effectiveness of the bubble production process.

Flowmeter for gas-entrained solids flow

DOEpatents

Porges, Karl G.

1990-01-01

An apparatus and method for the measurement of solids feedrate in a gas-entrained solids flow conveyance system. The apparatus and method of the present invention include a vertical duct connecting a source of solids to the gas-entrained flow conveyance system, a control valve positioned in the vertical duct, and a capacitive densitometer positioned along the duct at a location a known distance below the control valved so that the solid feedrate, Q, of the gas entrained flow can be determined by Q=S.rho..phi.V.sub.S where S is the cross sectional area of the duct, .rho. is the density of the solid, .phi. is the solid volume fraction determined by the capacitive densitometer, and v.sub.S is the local solid velocity which can be inferred from the konown distance of the capacitive densitometer below the control valve.

Conference on Fluid Machinery, 8th, Budapest, Hungary, Sept. 1987, Proceedings. Volumes 1 & 2

NASA Astrophysics Data System (ADS)

Szabo, A.; Kisbocskoi, L.

The present conference on turbomachine fluid mechanics gives attention to the analysis of labyrinth seals, irrigation turbomachinery, axial-flow fans, poppet valves, the generation of Karman vortices, self-rectifying Wells-type air turbines, computer simulations for water-supply systems, the computation of meridional flow in turbomachines, entrained air effects on vortex pump performance, the three-dimensional potential flow in a draft tube, and hydro powerplant diagnostic methods. Also discussed are a mathematical model for the initiation of cavitation wear, cryogenic flow in ejectors, flow downstream of guide vanes in a Kaplan turbine, unsteady flow in rotating cascades, novel methods for turbomachine vibration monitoring, cavitation breakdown in centrifugal pumps, test results for Banki turbines, centrifugal compressor return-channel flow, performance predictions for regenerative turbomachines, and secondary flows in a centrifugal pump.

Gas flow meter and method for measuring gas flow rate

DOEpatents

Robertson, Eric P.

2006-08-01

A gas flow rate meter includes an upstream line and two chambers having substantially equal, fixed volumes. An adjustable valve may direct the gas flow through the upstream line to either of the two chambers. A pressure monitoring device may be configured to prompt valve adjustments, directing the gas flow to an alternate chamber each time a pre-set pressure in the upstream line is reached. A method of measuring the gas flow rate measures the time required for the pressure in the upstream line to reach the pre-set pressure. The volume of the chamber and upstream line are known and fixed, thus the time required for the increase in pressure may be used to determine the flow rate of the gas. Another method of measuring the gas flow rate uses two pressure measurements of a fixed volume, taken at different times, to determine the flow rate of the gas.

Information systems in ADOT : an analysis of intra-function flow, decision support needs, existing systems utility and user attitudes. Final report, volume 3 : appendices

DOT National Transportation Integrated Search

1985-03-01

A report is offered on a study of the information activities within the Right-of-Way section of ADOT. The objectives of the study were to adapt and apply techniques to measure user-perceived needs, satisfaction and utility of services provided Right-...

Information systems in ADOT : an analysis of intra-function flow, decision support needs, existing systems utility and user attitudes. Final report, volume 1

DOT National Transportation Integrated Search

1985-03-01

A report is offered on a study of the information activities within the Right-of-Way section of ADOT. The objectives of the study were to adapt and apply techniques to measure user-perceived needs, satisfaction and utility of services provided Right-...

Mihi Breccia: A stack of lacustrine sediments and subaqueous pyroclastic flows within the Taupo Volcanic Zone, New Zealand

USGS Publications Warehouse

Downs, Drew

2016-01-01

The Taupo Volcanic Zone (TVZ), New Zealand, encompasses a wide variety of arc-related strata, although most of its small-volume (non-caldera-forming) eruptions are poorly-exposed and extensively hydrothermally altered. The Mihi Breccia is a stratigraphic sequence consisting of interbedded rhyolitic pyroclastic flows and lacustrine sediments with eruption ages of 281 ± 18 to at least 239 ± 6 ka (uncertainties at 2σ). In contrast to other small-volume rhyolitic eruptions within the TVZ, Mihi Breccia is relatively well-exposed within the Paeroa fault block, and contains minimal hydrothermal alteration. Pyroclastic flow characteristics and textures including: 1) breadcrusted juvenile clasts, 2) lack of welding, 3) abundant ash-rich matrix, 4) lack of fiamme and eutaxitic textures, 5) lack of thermal oxidation colors, 6) lack of cooling joints, 7) exclusive lacustrine sediment lithic clasts, and 8) interbedding with lacustrine sediments, all indicating that Mihi Breccia strata originated in a paleo-lake system. This ephemeral paleo-lake system is inferred to have lasted for > 50 kyr (based on Mihi Breccia age constraints), and referred to as Huka Lake. Mihi Breccia pyroclastic flow juvenile clast geochemistry and petrography correspond with similar-aged (264 ± 8, 263 ± 10, and 247 ± 4 ka) intra-caldera rhyolite domes filling the Reporoa caldera (source of the 281 ± 81 Kaingaroa Formation ignimbrite). These exposed intra-caldera rhyolite domes (as well as geophysically inferred subsurface domes) are proposed to be source vents for the Mihi Breccia pyroclastic flows. Soft-sediment deformation associated with Mihi Breccia strata indicate either seismic shock, rapid sediment loading during pyroclastic flow emplacement, or both. Thus, the Mihi Breccia reflects a prolonged series of subaqueous rhyolite dome building and associated pyroclastic flows, accompanied by seismic activity, emplaced into a large paleo-lake system within the TVZ.

Mihi Breccia: A stack of lacustrine sediments and subaqueous pyroclastic flows within the Taupo Volcanic Zone, New Zealand

NASA Astrophysics Data System (ADS)

Downs, Drew T.

2016-11-01

The Taupo Volcanic Zone (TVZ), New Zealand, encompasses a wide variety of arc-related strata, although most of its small-volume (non-caldera-forming) eruptions are poorly-exposed and extensively hydrothermally altered. The Mihi Breccia is a stratigraphic sequence consisting of interbedded rhyolitic pyroclastic flows and lacustrine sediments with eruption ages of 281 ± 18 to at least 239 ± 6 ka (uncertainties at 2σ). In contrast to other small-volume rhyolitic eruptions within the TVZ, Mihi Breccia is relatively well-exposed within the Paeroa fault block, and contains minimal hydrothermal alteration. Pyroclastic flow characteristics and textures include: 1) prismatically jointed juvenile clasts, 2) lack of welding, 3) abundant ash-rich matrix, 4) lack of fiamme and eutaxitic textures, 5) lack of thermal oxidation colors, 6) lack of cooling joints, 7) exclusive lacustrine sediment lithic clasts, and 8) interbedding with lacustrine sediments, all indicating that Mihi Breccia strata originated in a paleo-lake system. This ephemeral paleo-lake system is inferred to have lasted for > 50 kyr (based on Mihi Breccia age constraints), and referred to as Huka Lake. Mihi Breccia pyroclastic flow juvenile clast geochemistry and petrography correspond with similar-aged (264 ± 8, 263 ± 10, and 247 ± 4 ka) intra-caldera rhyolite domes filling the Reporoa caldera (source of the 281 ka Kaingaroa Formation ignimbrite). These exposed intra-caldera rhyolite domes (as well as geophysically inferred subsurface domes) are proposed to be source vents for the Mihi Breccia pyroclastic flows. Soft-sediment deformation associated with Mihi Breccia strata indicates either seismic shock, rapid sediment loading during pyroclastic flow emplacement, or both. Thus, the Mihi Breccia reflects a prolonged series of subaqueous rhyolite dome building and associated pyroclastic flows, accompanied by seismic activity, emplaced into a large paleo-lake system within the TVZ.

The prediction of radiofrequency ablation zone volume using vascular indices of 3-dimensional volumetric colour Doppler ultrasound in an in vitro blood-perfused bovine liver model

PubMed Central

Lanctot, Anthony C; McCarter, Martin D; Roberts, Katherine M; Glueck, Deborah H; Dodd, Gerald D

2017-01-01

Objective: To determine the most reliable predictor of radiofrequency (RF) ablation zone volume among three-dimensional (3D) volumetric colour Doppler vascular indices in an in vitro blood-perfused bovine liver model. Methods: 3D colour Doppler volume data of the local hepatic parenchyma were acquired from 37 areas of 13 bovine livers connected to an in vitro oxygenated blood perfusion system. Doppler vascular indices of vascularization index (VI), flow index (FI) and vascularization flow index (VFI) were obtained from the volume data using 3D volume analysis software. 37 RF ablations were performed at the same locations where the ultrasound data were obtained from. The relationship of these vascular indices and the ablation zone volumes measured from gross specimens were analyzed using a general linear mixed model fit with random effect for liver and backward stepwise regression analysis. Results: FI was significantly associated with ablation zone volumes measured on gross specimens (p = 0.0047), but explained little of the variance (Rβ2 = 0.21). Ablation zone volume decreased by 0.23 cm3 (95% confidence interval: −0.38, −0.08) for every 1 increase in FI. Neither VI nor VFI was significantly associated with ablation zone volumes (p > 0.05). Conclusion: Although FI was associated with ablation zone volumes, it could not sufficiently explain their variability, limiting its clinical applicability. VI, FI and VFI are not clinically useful in the prediction of RF ablation zone volume in the liver. Advances in knowledge: Despite a significant association of FI with ablation zone volumes, VI, FI and VFI cannot be used for their prediction. Different Doppler vascular indices need to be investigated for clinical use. PMID:27925468

In-vivo assessment of microvascular functional dynamics by combination of cmOCT and wavelet transform

NASA Astrophysics Data System (ADS)

Smirni, Salvatore; MacDonald, Michael P.; Robertson, Catherine P.; McNamara, Paul M.; O'Gorman, Sean; Leahy, Martin J.; Khan, Faisel

2018-02-01

The cutaneous microcirculation represents an index of the health status of the cardiovascular system. Conventional methods to evaluate skin microvascular function are based on measuring blood flow by laser Doppler in combination with reactive tests such as post-occlusive reactive hyperaemia (PORH). Moreover, the spectral analysis of blood flow signals by continuous wavelet transform (CWT) reveals nonlinear oscillations reflecting the functionality of microvascular biological factors, e.g. endothelial cells (ECs). Correlation mapping optical coherence tomography (cmOCT) has been previously described as an efficient methodology for the morphological visualisation of cutaneous micro-vessels. Here, we show that cmOCT flow maps can also provide information on the functional components of the microcirculation. A spectral domain optical coherence tomography (SD-OCT) imaging system was used to acquire 90 sequential 3D OCT volumes from the forearm of a volunteer, while challenging the micro-vessels with a PORH test. The volumes were sampled in a temporal window of 25 minutes, and were processed by cmOCT to obtain flow maps at different tissue depths. The images clearly show changes of flow in response to the applied stimulus. Furthermore, a blood flow signal was reconstructed from cmOCT maps intensities to investigate the microvascular nonlinear dynamics by CWT. The analysis revealed oscillations changing in response to PORH, associated with the activity of ECs and the sympathetic innervation. The results demonstrate that cmOCT may be potentially used as diagnostic tool for the assessment of microvascular function, with the advantage of also providing spatial resolution and structural information compared to the traditional laser Doppler techniques.

Pneumatic Proboscis Heat-Flow Probe

NASA Technical Reports Server (NTRS)

Zacny, Kris; Hedlund, Magnus; Mumm, Eric; Shasho, Jeffrey; Chu, Philip; Kumar, Nishant

2013-01-01

Heat flow is a fundamental property of a planet, and provides significant constraints on the abundance of radiogenic isotopes, the thermal evolution and differentiation history, and the mechanical properties of the lithosphere. Heat-flow measurements are also essential in achieving at least four of the goals set out by the National Research Council for future lunar exploration. The heat-flow probe therefore directly addresses the goal of the Lunar Geophysical Network, which is to understand the interior structure and composition of the Moon. A key challenge for heat flow measurement is to install thermal sensors to the depths approximately equal to 3 m that are not influenced by the diurnal, annual, and longer-term fluctuations of the surface thermal environment. In addition, once deployed, the heat flow probe should cause little disturbance to the thermal regime of the surrounding regolith. A heat-flow probe system was developed that has two novel features: (1) it utilizes a pneumatic (gas) approach, excavates a hole by lofting the lunar soil out of the hole, and (2) deploys the heat flow probe, which utilizes a coiled up tape as a thermal probe to reach greater than 3-meter depth. The system is a game-changer for small lunar landers as it exhibits extremely low mass, volume, and simple deployment. The pneumatic system takes advantage of the helium gas used for pressurizing liquid propellant of the lander. Normally, helium is vented once the lander is on the surface, but it can be utilized for powering pneumatic systems. Should sufficient helium not be available, a simple gas delivery system may be taken specifically for the heat flow probe. Either way, the pneumatic heat flow probe system would be much lighter than other systems that entirely rely on the electrical power of the lander.

Stage-by-Stage and Parallel Flow Path Compressor Modeling for a Variable Cycle Engine, NASA Advanced Air Vehicles Program - Commercial Supersonic Technology Project - AeroServoElasticity

NASA Technical Reports Server (NTRS)

Kopasakis, George; Connolly, Joseph W.; Cheng, Larry

2015-01-01

This paper covers the development of stage-by-stage and parallel flow path compressor modeling approaches for a Variable Cycle Engine. The stage-by-stage compressor modeling approach is an extension of a technique for lumped volume dynamics and performance characteristic modeling. It was developed to improve the accuracy of axial compressor dynamics over lumped volume dynamics modeling. The stage-by-stage compressor model presented here is formulated into a parallel flow path model that includes both axial and rotational dynamics. This is done to enable the study of compressor and propulsion system dynamic performance under flow distortion conditions. The approaches utilized here are generic and should be applicable for the modeling of any axial flow compressor design accurate time domain simulations. The objective of this work is as follows. Given the parameters describing the conditions of atmospheric disturbances, and utilizing the derived formulations, directly compute the transfer function poles and zeros describing these disturbances for acoustic velocity, temperature, pressure, and density. Time domain simulations of representative atmospheric turbulence can then be developed by utilizing these computed transfer functions together with the disturbance frequencies of interest.

Spool Valve for Switching Air Flows Between Two Beds

NASA Technical Reports Server (NTRS)

Dean, W. Clark

2005-01-01

U.S. Patent 6,142,151 describes a dual-bed ventilation system for a space suit, with emphasis on a multiport spool valve that switches air flows between two chemical beds that adsorb carbon dioxide and water vapor. The valve is used to alternately make the air flow through one bed while exposing the other bed to the outer-space environment to regenerate that bed through vacuum desorption of CO2 and H2O. Oxygen flowing from a supply tank is routed through a pair of periodically switched solenoid valves to drive the spool valve in a reciprocating motion. The spool valve equalizes the pressures of air in the beds and the volumes of air flowing into and out of the beds during the alternations between the adsorption and desorption phases, in such a manner that the volume of air that must be vented to outer space is half of what it would be in the absence of pressure equalization. Oxygen that has been used to actuate the spool valve in its reciprocating motion is released into the ventilation loop to replenish air lost to vacuum during the previous desorption phase of the operating cycle.

Gas Control System for HEAO-B

NASA Technical Reports Server (NTRS)

Taylor, B.; Brissette, R.; Humphrey, A.; Morris, J.; Luger, J.; Swift, W.

1978-01-01

The HEAO-B Gas Control System consists of a high pressure gas storage supply together with distribution and regulation assemblies and their associated electronics for management of gas required for HEAO-B X-ray counter experiments. The Gas Control System replenishes a gas mixture (82 percent argon, 12.3 percent carbon dioxide, 5.7 percent xenon) in the counter volumes which is lost by: diffusion through controlled leakage plugs, diffusion through counter windows, and consumption resulting from periodic purges. The gas density in each counter volume is maintained constant to within 0.25 percent by comparison with a sealed reference volume. The system is fully redundant, capable of operating at atmospheric pressure as well as in a vacuum, contains interlocks which shut down gas flow in the event of either leakage or excessive pressure, and is able to shut down counter high voltage if counter pressure is abnormally low. The system is electronically controlled by ground command and self-sustaining in orbit for a period of at least one year.

Understanding leachate flow in municipal solid waste landfills by combining time-lapse ERT and subsurface flow modelling - Part II: Constraint methodology of hydrodynamic models.

PubMed

Audebert, M; Oxarango, L; Duquennoi, C; Touze-Foltz, N; Forquet, N; Clément, R

2016-09-01

Leachate recirculation is a key process in the operation of municipal solid waste landfills as bioreactors. To ensure optimal water content distribution, bioreactor operators need tools to design leachate injection systems. Prediction of leachate flow by subsurface flow modelling could provide useful information for the design of such systems. However, hydrodynamic models require additional data to constrain them and to assess hydrodynamic parameters. Electrical resistivity tomography (ERT) is a suitable method to study leachate infiltration at the landfill scale. It can provide spatially distributed information which is useful for constraining hydrodynamic models. However, this geophysical method does not allow ERT users to directly measure water content in waste. The MICS (multiple inversions and clustering strategy) methodology was proposed to delineate the infiltration area precisely during time-lapse ERT survey in order to avoid the use of empirical petrophysical relationships, which are not adapted to a heterogeneous medium such as waste. The infiltration shapes and hydrodynamic information extracted with MICS were used to constrain hydrodynamic models in assessing parameters. The constraint methodology developed in this paper was tested on two hydrodynamic models: an equilibrium model where, flow within the waste medium is estimated using a single continuum approach and a non-equilibrium model where flow is estimated using a dual continuum approach. The latter represents leachate flows into fractures. Finally, this methodology provides insight to identify the advantages and limitations of hydrodynamic models. Furthermore, we suggest an explanation for the large volume detected by MICS when a small volume of leachate is injected. Copyright © 2016 Elsevier Ltd. All rights reserved.

Direct Measurement of Proximal Isovelocity Surface Area by Real-Time Three-Dimensional Color Doppler for Quantitation of Aortic Regurgitant Volume: An In Vitro Validation

PubMed Central

Pirat, Bahar; Little, Stephen H.; Igo, Stephen R.; McCulloch, Marti; Nosé, Yukihiko; Hartley, Craig J.; Zoghbi, William A.

2012-01-01

Objective The proximal isovelocity surface area (PISA) method is useful in the quantitation of aortic regurgitation (AR). We hypothesized that actual measurement of PISA provided with real-time 3-dimensional (3D) color Doppler yields more accurate regurgitant volumes than those estimated by 2-dimensional (2D) color Doppler PISA. Methods We developed a pulsatile flow model for AR with an imaging chamber in which interchangeable regurgitant orifices with defined shapes and areas were incorporated. An ultrasonic flow meter was used to calculate the reference regurgitant volumes. A total of 29 different flow conditions for 5 orifices with different shapes were tested at a rate of 72 beats/min. 2D PISA was calculated as 2π r2, and 3D PISA was measured from 8 equidistant radial planes of the 3D PISA. Regurgitant volume was derived as PISA × aliasing velocity × time velocity integral of AR/peak AR velocity. Results Regurgitant volumes by flow meter ranged between 12.6 and 30.6 mL/beat (mean 21.4 ± 5.5 mL/beat). Regurgitant volumes estimated by 2D PISA correlated well with volumes measured by flow meter (r = 0.69); however, a significant underestimation was observed (y = 0.5x + 0.6). Correlation with flow meter volumes was stronger for 3D PISA-derived regurgitant volumes (r = 0.83); significantly less underestimation of regurgitant volumes was seen, with a regression line close to identity (y = 0.9x + 3.9). Conclusion Direct measurement of PISA is feasible, without geometric assumptions, using real-time 3D color Doppler. Calculation of aortic regurgitant volumes with 3D color Doppler using this methodology is more accurate than conventional 2D method with hemispheric PISA assumption. PMID:19168322

Impact of sludge layer geometry on the hydraulic performance of a waste stabilization pond.

PubMed

Ouedraogo, Faissal R; Zhang, Jie; Cornejo, Pablo K; Zhang, Qiong; Mihelcic, James R; Tejada-Martinez, Andres E

2016-08-01

Improving the hydraulic performance of waste stabilization ponds (WSPs) is an important management strategy to not only ensure protection of public health and the environment, but also to maximize the potential reuse of valuable resources found in the treated effluent. To reuse effluent from WSPs, a better understanding of the factors that impact the hydraulic performance of the system is needed. One major factor determining the hydraulic performance of a WSP is sludge accumulation, which alters the volume of the pond. In this study, computational fluid dynamics (CFD) analysis was applied to investigate the impact of sludge layer geometry on hydraulic performance of a facultative pond, typically used in many small communities throughout the developing world. Four waste stabilization pond cases with different sludge volumes and distributions were investigated. Results indicate that sludge distribution and volume have a significant impact on wastewater treatment efficiency and capacity. Although treatment capacity is reduced with accumulation of sludge, the latter may induce a baffling effect which causes the flow to behave closer to that of plug flow reactor and thus increase treatment efficiency. In addition to sludge accumulation and distribution, the impact of water surface level is also investigated through two additional cases. Findings show that an increase in water level while keeping a constant flow rate can result in a significant decrease in the hydraulic performance by reducing the sludge baffling effect, suggesting a careful monitoring of sludge accumulation and water surface level in WSP systems. Published by Elsevier Ltd.

Effects of reduced return activated sludge flows and volume on anaerobic zone performance for a septic wastewater biological phosphorus removal system.

PubMed

Magro, Daniel; Elias, Steven L; Randall, Andrew Amis

2005-01-01

Enhanced biological phosphorous removal (EBPR) performance was found to be adequate with reduced return-activated sludge (RAS) flows (50% of available RAS) to the anaerobic tank and smaller-than-typical anaerobic zone volume (1.08 hours hydraulic retention time [HRT]). Three identical parallel biological nutrient removal pilot plants were fed with strong, highly fermented (160 mg/L volatile fatty acids [VFAs]), domestic and industrial wastewater from a full-scale wastewater treatment facility. The pilot plants were operated at 100, 50, 40, and 25% RAS (percent of available RAS) flows to the anaerobic tank, with the remaining RAS to the anoxic tank. In addition, varying anaerobic HRT (1.08 and 1.5 hours) and increased hydraulic loading (35% increase) were examined. The study was divided into four phases, and the effect of these process variations on EBPR were studied by having one different variable between two identical systems. The most significant conclusion was that returning part of the RAS to the anaerobic zone did not decrease EBPR performance; instead, it changed the location of phosphorous release and uptake. Bringing less RAS to the anaerobic and more to the anoxic tank decreased anaerobic phosphorus release and increased anoxic phosphorus release (or decreased anoxic phosphorus uptake). Equally important is that, with VFA-rich influent wastewater, excessive anaerobic volume was shown to hurt overall phosphorus removal, even when it resulted in increased anaerobic phosphorus release.

Small-volume, ultrahigh-vacuum-compatible high-pressure reaction cell for combined kinetic and in situ IR spectroscopic measurements on planar model catalysts

NASA Astrophysics Data System (ADS)

Zhao, Z.; Diemant, T.; Häring, T.; Rauscher, H.; Behm, R. J.

2005-12-01

We describe the design and performance of a high-pressure reaction cell for simultaneous kinetic and in situ infrared reflection (IR) spectroscopic measurements on model catalysts at elevated pressures, between 10-3 and 103mbars, which can be operated both as batch reactor and as flow reactor with defined gas flow. The cell is attached to an ultrahigh-vacuum (UHV) system, which is used for sample preparation and also contains facilities for sample characterization. Specific for this design is the combination of a small cell volume, which allows kinetic measurements with high sensitivity under batch or continuous flow conditions, the complete isolation of the cell from the UHV part during UHV measurements, continuous temperature control during both UHV and high-pressure operation, and rapid transfer between UHV and high-pressure stage. Gas dosing is performed by a designed gas-handling system, which allows operation as flow reactor with calibrated gas flows at adjustable pressures. To study the kinetics of reactions on the model catalysts, a quadrupole mass spectrometer is connected to the high-pressure cell. IR measurements are possible in situ by polarization-modulation infrared reflection-absorption spectroscopy, which also allows measurements at elevated pressures. The performance of the setup is demonstrated by test measurements on the kinetics for CO oxidation and the CO adsorption on a Au /TiO2/Ru(0001) model catalyst film at 1-50 mbar total pressure.

Gas flow headspace liquid phase microextraction.

PubMed

Yang, Cui; Qiu, Jinxue; Ren, Chunyan; Piao, Xiangfan; Li, Xifeng; Wu, Xue; Li, Donghao

2009-11-06

There is a trend towards the use of enrichment techniques such as microextraction in the analysis of trace chemicals. Based on the theory of ideal gases, theory of gas chromatography and the original headspace liquid phase microextraction (HS-LPME) technique, a simple gas flow headspace liquid phase microextraction (GF-HS-LPME) technique has been developed, where the extracting gas phase volume is increased using a gas flow. The system is an open system, where an inert gas containing the target compounds flows continuously through a special gas outlet channel (D=1.8mm), and the target compounds are trapped on a solvent microdrop (2.4 microL) hanging on the microsyringe tip, as a result, a high enrichment factor is obtained. The parameters affecting the enrichment factor, such as the gas flow rate, the position of the microdrop, the diameter of the gas outlet channel, the temperatures of the extracting solvent and of the sample, and the extraction time, were systematically optimized for four types of polycyclic aromatic hydrocarbons. The results were compared with results obtained from HS-LPME. Under the optimized conditions (where the extraction time and the volume of the extracting sample vial were fixed at 20min and 10mL, respectively), detection limits (S/N=3) were approximately a factor of 4 lower than those for the original HS-LPME technique. The method was validated by comparison of the GF-HS-LPME and HS-LPME techniques using data for PAHs from environmental sediment samples.

An open-loop controlled active lung simulator for preterm infants.

PubMed

Cecchini, Stefano; Schena, Emiliano; Silvestri, Sergio

2011-01-01

We describe the underlying theory, design and experimental evaluation of an electromechanical analogue infant lung to simulate spontaneous breathing patterns of preterm infants. The aim of this work is to test the possibility to obtain breathing patterns of preterm infants by taking into consideration the air compressibility. Respiratory volume function represents the actuation pattern, and pulmonary pressure and flow-rate waveforms are mathematically obtained through the application of the perfect gas and adiabatic laws. The mathematical model reduces the simulation interval into a step shorter than 1 ms, allowing to consider an entire respiratory act as composed of a large number of almost instantaneous adiabatic transformations. The device consists of a spherical chamber where the air is compressed by four cylinder-pistons, moved by stepper motors, and flows through a fluid-dynamic resistance, which also works as flow-rate sensor. Specifically designed software generates the actuators motion, based on the desired ventilation parameters, without controlling the gas pneumatic parameters with a closed-loop. The system is able to simulate tidal volumes from 3 to 8 ml, breathing frequencies from 60 to 120 bpm and functional residual capacities from 25 to 80 ml. The simulated waveforms appear very close to the measured ones. Percentage differences on the tidal volume waveform vary from 7% for the tidal volume of 3 ml, down to 2.2-3.5% for tidal volumes in the range of 4-7 ml, and 1.3% for the tidal volume equal to 8 ml in the whole breathing frequency and functional residual capacity ranges. The open-loop electromechanical simulator shows that gas compressibility can be theoretically assessed in the typical pneumatic variable range of preterm infant respiratory mechanics. Copyright © 2010 IPEM. Published by Elsevier Ltd. All rights reserved.

Evaluation of Flow Biosensor Technology in a Chronically-Instrumented Non-Human Primate Model

NASA Technical Reports Server (NTRS)

Koenig, S. C.; Reister, C.; Schaub, J.; Muniz, G.; Ferguson, T.; Fanton, J. W.

1995-01-01

The Physiology Research Branch of Brooks AFB conducts both human and non-human primate experiments to determine the effects of microgravity and hypergravity on the cardiovascular system and to indentify the particular mechanisms that invoke these responses. Primary investigative research efforts in a non-human primate model require the calculation of total peripheral resistance (TPR), systemic arterial compliance (SAC), and pressure-volume loop characteristics. These calculations require beat-to-beat measurement of aortic flow. We have evaluated commercially available electromagnetic (EMF) and transit-time flow measurement techniques. In vivo and in vitro experiments demonstrated that the average error of these techniques is less than 25 percent for EMF and less than 10 percent for transit-time.

A theoretical analysis of fluid flow and energy transport in hydrothermal systems

USGS Publications Warehouse

Faust, Charles R.; Mercer, James W.

1977-01-01

A mathematical derivation for fluid flow and energy transport in hydrothermal systems is presented. Specifically, the mathematical model describes the three-dimensional flow of both single- and two-phase, single-component water and the transport of heat in porous media. The derivation begins with the point balance equations for mass, momentum, and energy. These equations are then averaged over a finite volume to obtain the macroscopic balance equations for a porous medium. The macroscopic equations are combined by appropriate constitutive relationships to form two similified partial differential equations posed in terms of fluid pressure and enthalpy. A two-dimensional formulation of the simplified equations is also derived by partial integration in the vertical dimension. (Woodard-USGS)

How to Recharge a Confined Aquifer: An Exploration of Geologic Controls on Groundwater Storage.

NASA Astrophysics Data System (ADS)

Maples, S.; Fogg, G. E.; Maxwell, R. M.; Liu, Y.

2017-12-01

Decreased snowpack storage and groundwater overdraft in California has increased interest in managed aquifer recharge (MAR) of excess winter runoff to the Central Valley aquifer system, which has unused storage capacity that far exceeds the state's surface reservoirs. Recharge to the productive, confined aquifer system remains a challenge due to the presence of nearly-ubiquitous, multiple silt and clay confining units that limit recharge pathways. However, previous studies have identified interconnected networks of sand and gravel deposits that bypass the confining units and accommodate rapid, high-volume recharge to the confined aquifer system in select locations. We use the variably-saturated, fully-integrated groundwater/surface-water flow code, ParFlow, in combination with a high-resolution, transition probability Markov-chain geostatistical model of the subsurface geologic heterogeneity of the east side of the Sacramento Valley, CA, to characterize recharge potential across a landscape that includes these geologic features. Multiple 180-day MAR simulations show that recharge potential is highly dependent on subsurface geologic structure, with a several order-of-magnitude range of recharge rates and volumes across the landscape. Where there are recharge pathways to the productive confined-aquifer system, pressure propagation in the confined system is widespread and rapid, with multi-kilometer lateral pressure propagation. Although widespread pressure propagation occurs in the confined system, only a small fraction of recharge volume is accommodated there. Instead, the majority of recharge occurs by filling unsaturated pore spaces. Where they outcrop at land surface, high-K recharge pathways fill rapidly, accommodating the majority of recharge during early time. However, these features become saturated quickly, and somewhat counterintuitively, the low-K silt and clay facies accommodate the majority of recharge volume during most of the simulation. These findings (1) highlight the large variability of MAR potential across the landscape, wherein the recharge capacity in select areas far exceeds recharge potential over most of the landscape, and (2) elucidate important physical processes that control MAR potential in alluvial aquifer systems.

Advancements in Dual-Pump Broadband CARS for Supersonic Combustion Measurements

NASA Technical Reports Server (NTRS)

Tedder, Sarah Augusta Umberger

2010-01-01

Space- and time-resolved measurements of temperature and species mole fractions of nitrogen, oxygen, and hydrogen were obtained with a dual-pump coherent anti-Stokes Raman spectroscopy (CARS) system in hydrogen-fueled supersonic combustion free jet flows. These measurements were taken to provide time-resolved fluid properties of turbulent supersonic combustion for use in the creation and verification of computational fluid dynamic (CFD) models. CFD models of turbulent supersonic combustion flow currently facilitate the design of air-breathing supersonic combustion ramjet (scramjet) engines. Measurements were made in supersonic axi-symmetric free jets of two scales. First, the measurement system was tested in a laboratory environment using a laboratory-scale burner (approx.10 mm at nozzle exit). The flow structures of the laboratory-burner were too small to be resolved with the CARS measurements volume, but the composition and temperature of the jet allowed the performance of the system to be evaluated. Subsequently, the system was tested in a burner that was approximately 6 times larger, whose length scales are better resolved by the CARS measurement volume. During both these measurements, weaknesses of the CARS system, such as sensitivity to vibrations and beam steering and inability to measure temperature or species concentrations in hydrogen fuel injection regions were indentified. Solutions were then implemented in improved CARS systems. One of these improved systems is a dual-pump broadband CARS technique called, Width Increased Dual-pump Enhanced CARS (WIDECARS). The two lowest rotational energy levels of hydrogen detectable by WIDECARS are H2 S(3) and H2 S(4). The detection of these lines gives the system the capability to measure temperature and species concentrations in regions of the flow containing pure hydrogen fuel at room temperature. WIDECARS is also designed for measurements of all the major species (except water) in supersonic combustion flows fueled with hydrogen and hydrogen/ethylene mixtures (N2, O2, H2, C2H4, CO, and CO2). This instrument can characterize supersonic combustion fueled with surrogate fuel mixtures of hydrogen and ethylene. This information can lead to a better understanding of the chemistry and performance of supersonic combustion fueled with cracked jet propulsion (JP)-type fuel.

Four-dimensional Doppler ultrasound measurements in carotid bifurcation models: effect of concentric versus eccentric stenosis

NASA Astrophysics Data System (ADS)

Poepping, Tamie L.; Rankin, Richard N.; Holdsworth, David W.

2001-05-01

A unique in-vitro system has been developed that incorporates both realistic phantoms and flow. The anthropomorphic carotid phantoms are fabricated in agar with stenosis severity of 30% or 70% (by NASCET standards) and one of two geometric configurations- concentric or eccentric. The phantoms are perfused with a flow waveform that simulates normal common carotid flow. Pulsed Doppler ultrasound data are acquired at a 1 mm grid spacing throughout the lumen of the carotid bifurcation. To obtain a half-lumen volume, symmetric about the mid plane, requires a 13 hour acquisition over 3238 interrogation sites, producing 5.6 Gbytes of data. The spectral analysis produces estimates of parameters such as the peak velocity, mean velocity, spectral-broadening index, and turbulence intensity. Color-encoded or grayscale-encoded maps of these spectral parameters show distinctly different flow patterns resulting from stenoses of equal severity but different eccentricity. The most noticeable differences are seen in the volumes of the recirculation zones and the paths of the high-velocity jets. Elevated levels of turbulence intensity are also seen distal to the stenosis in the 70%-stenosed models.

Air elimination capability in rapid infusion systems.

PubMed

Zoremba, N; Gruenewald, C; Zoremba, M; Rossaint, R; Schaelte, G

2011-11-01

Pressure infusion devices are used in clinical practice to apply large volumes of fluid over a short period of time. Although air infusion is a major complication, they have limited capability to detect and remove air during pressure infusion. In this investigation, we tested the air elimination capabilities of the Fluido(®) (The Surgical Company), Level 1(®) (Level 1 Technologies Inc.) and Ranger(®) (Augustine Medical GmbH) pressure infusion devices. Measurements were undertaken with a crystalloid solution during an infusion flow of 100, 200, 400 and 800 ml.min(-1). Four different volumes of air (25, 50, 100 and 200 ml) were injected as boluses in one experimental setting, or infused continuously over the time needed to perfuse 2 l saline in the other setting. The perfusion fluid was collected in an airtight infusion bag and the amount of air obtained in the bag was measured. The delivered air volume was negligible and would not cause any significant air embolism in all experiments. In our experimental setting, we found, during high flow, an increased amount of uneliminated air in all used devices compared with lower perfusion flows. All tested devices had a good air elimination capability. The use of ultrasonic air detection coupled with an automatic shutoff is a significant safety improvement and can reliably prevent accidental air embolism at rapid flows. © 2011 The Authors. Anaesthesia © 2011 The Association of Anaesthetists of Great Britain and Ireland.

An analysis of finite-difference and finite-volume formulations of conservation laws

NASA Technical Reports Server (NTRS)

Vinokur, Marcel

1986-01-01

Finite-difference and finite-volume formulations are analyzed in order to clear up the confusion concerning their application to the numerical solution of conservation laws. A new coordinate-free formulation of systems of conservation laws is developed, which clearly distinguishes the role of physical vectors from that of algebraic vectors which characterize the system. The analysis considers general types of equations--potential, Euler, and Navier-Stokes. Three-dimensional unsteady flows with time-varying grids are described using a single, consistent nomeclature for both formulations. Grid motion due to a non-inertial reference frame as well as flow adaptation is covered. In comparing the two formulations, it is found useful to distinguish between differences in numerical methods and differences in grid definition. The former plays a role for non-Cartesian grids, and results in only cosmetic differences in the manner in which geometric terms are handled. The differences in grid definition for the two formulations is found to be more important, since it affects the manner in which boundary conditions, zonal procedures, and grid singularities are handled at computational boundaries. The proper interpretation of strong and weak conservation-law forms for quasi-one-dimensional and axisymmetric flows is brought out.

Electro-thermo-mechanical nonlinear nonlocal vibration and instability of embedded micro-tube reinforced by BNNT, conveying fluid

NASA Astrophysics Data System (ADS)

Ghorbanpour Arani, A.; Shajari, A. R.; Amir, S.; Loghman, A.

2012-08-01

Nonlinear vibration and stability of a smart composite micro-tube made of Poly-vinylidene fluoride (PVDF) reinforced by Boron-Nitride nanotubes (BNNTs) embedded in an elastic medium under electro-thermal loadings is investigated. The BNNTs are considered to be long straight fibers and the composite used in this study is in the category of piezoelectric fiber reinforced composites (PEFRC). The micro-tube is conveying a fully developed isentropic, incompressible and irrotational fluid flow. The smart micro-tube is modeled as a thin shell based on the nonlinear Donnell's shell theory. Effects of mean flow velocity, fluid viscosity, elastic medium modulus, temperature change, imposed electric potential, small scale, aspect ratio, volume percent and orientation angle of the BNNTs on the vibration behavior of the micro-tube are taken into account. The results indicate that increasing mean flow velocity considerably increases the nonlinearity effects so that small scale and temperature change effects become negligible. It has also been found that stability of the system is strongly dependent on the imposed electric potential and the volume percent of BNNTs reinforcement. The system studied in this article can be used as sensor and actuator in the sensitive applications.

Electrically Driven Liquid Film Boiling Experiment

NASA Technical Reports Server (NTRS)

Didion, Jeffrey R.

2016-01-01

This presentation presents the science background and ground based results that form the basis of the Electrically Driven Liquid Film Boiling Experiment. This is an ISS experiment that is manifested for 2021. Objective: Characterize the effects of gravity on the interaction of electric and flow fields in the presence of phase change specifically pertaining to: a) The effects of microgravity on the electrically generated two-phase flow. b) The effects of microgravity on electrically driven liquid film boiling (includes extreme heat fluxes). Electro-wetting of the boiling section will repel the bubbles away from the heated surface in microgravity environment. Relevance/Impact: Provides phenomenological foundation for the development of electric field based two-phase thermal management systems leveraging EHD, permitting optimization of heat transfer surface area to volume ratios as well as achievement of high heat transfer coefficients thus resulting in system mass and volume savings. EHD replaces buoyancy or flow driven bubble removal from heated surface. Development Approach: Conduct preliminary experiments in low gravity and ground-based facilities to refine technique and obtain preliminary data for model development. ISS environment required to characterize electro-wetting effect on nucleate boiling and CHF in the absence of gravity. Will operate in the FIR - designed for autonomous operation.

High speed flow cytometer droplet formation system and method

DOEpatents

Van den Engh, Ger

2000-01-01

A droplet forming flow cytometer system allows high speed processing without the need for high oscillator drive powers through the inclusion of an oscillator or piezoelectric crystal such as within the nozzle volume or otherwise unidirectionally coupled to the sheath fluid. The nozzle container continuously converges so as to amplify unidirectional oscillations which are transmitted as pressure waves through the nozzle volume to the nozzle exit so as to form droplets from the fluid jet. The oscillator is directionally isolated so as to avoid moving the entire nozzle container so as to create only pressure waves within the sheath fluid. A variation in substance concentration is achieved through a movable substance introduction port which is positioned within a convergence zone to vary the relative concentration of substance to sheath fluid while still maintaining optimal laminar flow conditions. This variation may be automatically controlled through a sensor and controller configuration. A replaceable tip design is also provided whereby the ceramic nozzle tip is positioned within an edge insert in the nozzle body so as to smoothly transition from nozzle body to nozzle tip. The nozzle tip is sealed against its outer surface to the nozzle body so it may be removable for cleaning or replacement.

In the making: SA-PIV applied to swimming practice

NASA Astrophysics Data System (ADS)

van Houwelingen, Josje; van de Water, Willem; Kunnen, Rudie; van Heijst, Gertjan; Clercx, Herman

2017-11-01

To understand and optimize the propulsion in human swimming, a deep understanding of the hydrodynamics of swimming is required. This is usually based on experiments and numerical simulations under laboratory conditions.. In this study, we bring basic fluid mechanics knowledge and experimental measurement techniques to analyze the flow towards the swimming practice itself. A flow visualization setup is build and placed in a regular swimming pool. The measurement volume contains five homogeneous air bubble curtains illuminated by ambient light. The bubbles in these curtains act as tracer particles. The bubble motion is captured by six cameras placed in the side wall of the pool. It is intended to apply SA-PIV (synthetic aperture PIV) for analyzing the flow structures on multiple planes in the measurement volume. The system has been calibrated and the calibration data are used to refocus on the planes of interest. Multiple preprocessing steps need to be executed to obtain the proper quality of images before applying PIV. With a specially programmed video card to process and analyze the images in real-time feedback about swimming performance will become possible. We report on the first experimental data obtained by this system.

Protein separation through preliminary experiments concerning pH and salt concentration by tube radial distribution chromatography based on phase separation multiphase flow using a polytetrafluoroethylene capillary tube.

PubMed

Kan, Hyo; Tsukagoshi, Kazuhiko

2017-07-01

Protein mixtures were separated using tube radial distribution chromatography (TRDC) in a polytetrafluoroethylene (PTFE) capillary (internal diameter=100µm) separation tube. Separation by TRDC is based on the annular flow in phase separation multiphase flow and features an open-tube capillary without the use of specific packing agents or application of high voltages. Preliminary experiments were conducted to examine the effects of pH and salt concentration on the phase diagram of the ternary mixed solvent solution of water-acetonitrile-ethyl acetate (8:2:1 volume ratio) and on the TRDC system using the ternary mixed solvent solution. A model protein mixture containing peroxidase, lysozyme, and bovine serum albumin was analyzed via TRDC with the ternary mixed solvent solution at various pH values, i.e., buffer-acetonitrile-ethyl acetate (8:2:1 volume ratio). Protein was separated on the chromatograms by the TRDC system, where the elution order was determined by the relation between the isoelectric points of protein and the pH values of the solvent solution. Copyright © 2017 Elsevier B.V. All rights reserved.

An analysis of finite-difference and finite-volume formulations of conservation laws

NASA Technical Reports Server (NTRS)

Vinokur, Marcel

1989-01-01

Finite-difference and finite-volume formulations are analyzed in order to clear up the confusion concerning their application to the numerical solution of conservation laws. A new coordinate-free formulation of systems of conservation laws is developed, which clearly distinguishes the role of physical vectors from that of algebraic vectors which characterize the system. The analysis considers general types of equations: potential, Euler, and Navier-Stokes. Three-dimensional unsteady flows with time-varying grids are described using a single, consistent nomenclature for both formulations. Grid motion due to a non-inertial reference frame as well as flow adaptation is covered. In comparing the two formulations, it is found useful to distinguish between differences in numerical methods and differences in grid definition. The former plays a role for non-Cartesian grids, and results in only cosmetic differences in the manner in which geometric terms are handled. The differences in grid definition for the two formulations is found to be more important, since it affects the manner in which boundary conditions, zonal procedures, and grid singularities are handled at computational boundaries. The proper interpretation of strong and weak conservation-law forms for quasi-one-dimensional and axisymmetric flows is brought out.

Assessment and monitoring of flow limitation and other parameters from flow/volume loops.

PubMed

Dueck, R

2000-01-01

Flow/volume (F/V) spirometry is routinely used for assessing the type and severity of lung disease. Forced vital capacity (FVC) and timed vital capacity (FEV1) provide the best estimates of airflow obstruction in patients with asthma, chronic obstructive pulmonary disease (COPD) and emphysema. Computerized spirometers are now available for early home recognition of asthma exacerbation in high risk patients with severe persistent disease, and for recognition of either infection or rejection in lung transplant patients. Patients with severe COPD may exhibit expiratory flow limitation (EFL) on tidal volume (VT) expiratory F/V (VTF/V) curves, either with or without applying negative expiratory pressure (NEP). EFL results in dynamic hyperinflation and persistently raised alveolar pressure or intrinsic PEEP (PEEPi). Hyperinflation and raised PEEPi greatly enhance dyspnea with exertion through the added work of the threshold load needed to overcome raised pleural pressure. Esophageal (pleural) pressure monitoring may be added to VTF/V loops for assessing the severity of PEEPi: 1) to optimize assisted ventilation by mask or via endotracheal tube with high inspiratory flow rates to lower I:E ratio, and 2) to assess the efficacy of either pressure support ventilation (PSV) or low level extrinsic PEEP in reducing the threshold load of PEEPi. Intraoperative tidal volume F/V loops can also be used to document the efficacy of emphysema lung volume reduction surgery (LVRS) via disappearance of EFL. Finally, the mechanism of ventilatory constraint can be identified with the use of exercise tidal volume F/V loops referenced to maximum F/V loops and static lung volumes. Patients with severe COPD show inspiratory F/V loops approaching 95% of total lung capacity, and flow limitation over the entire expiratory F/V curve during light levels of exercise. Surprisingly, patients with a history of congestive heart failure may lower lung volume towards residual volume during exercise, thereby reducing airway diameter and inducing expiratory flow limitation.

A 4-cylinder Stirling engine computer program with dynamic energy equations

NASA Technical Reports Server (NTRS)

Daniele, C. J.; Lorenzo, C. F.

1983-01-01

A computer program for simulating the steady state and transient performance of a four cylinder Stirling engine is presented. The thermodynamic model includes both continuity and energy equations and linear momentum terms (flow resistance). Each working space between the pistons is broken into seven control volumes. Drive dynamics and vehicle load effects are included. The model contains 70 state variables. Also included in the model are piston rod seal leakage effects. The computer program includes a model of a hydrogen supply system, from which hydrogen may be added to the system to accelerate the engine. Flow charts are provided.

Reconstructing the groundwater flow in the Baltic Basin during the Last glaciation

NASA Astrophysics Data System (ADS)

Saks, T.; Sennikovs, J.; Timuhins, A.; Kalvāns, A.

2012-04-01

In last decades it has been discussed that most large ice sheets tend to reside on warm beds even in harsh clima tic conditions and subglacial melting occurs due to geothermal heat flow and deformation heat of the ice flow. However the subglacial groundwater recharge and flow conditions have been addressed in only few studies. The aim of this study is to establish the groundwater flow pattern in the Baltic Basin below the Scandinavian ice sheet during the Late Weichselian glaciation. The calculation results are compared to the known distribution of the groundwater body of the glacial origin found in Cambrian - Vendian (Cm-V) aquifer in the Northern Estonia which is believed to have originated as a result of subglacial meltwater infiltration during the reoccurring glaciations. Steady state regional groundwater flow model of the Baltic Basin was used to simulate the groundwater flow beneath the ice sheet with its geometry adjusted to reflect the subglacial topography. Ice thickness modelling data (Argus&Peltier, 2010) was used for the setup of the boundary conditions: the meltwater pressure at the ice bed was assumed equal to the overlying ice mass. The modelling results suggest two main recharge areas of the Cm-V aquifer system, and reversed groundwater flow that persisted for at least 14 thousand years. Model results show that the groundwater flow velocities in the Cm-V aquifer in the recharge area in N-Estonia beneath the ice sheet exceeded the present velocities by a factor of 10 on average. The calculated meltwater volume recharged into the Cm-V aquifer system during the Late Weichselian corresponds roughly to the estimated, however, considering the fact, that the study area has been glaciated at least 4 times this is an overestimation. The modeling results attest the hypothesis of light dO18 groundwater glacial origin in the Cm-V aquifer system, however the volumes, timing and processes involved in the meltwater intrusion are yet to be explored. This study was financed by the European Social fund Nr. 2009/0212/1DP/1.1.1.2.0/09/APIA/VIAA/060

Methods of blood flow measurement in the arterial circulatory system.

PubMed

Tabrizchi, R; Pugsley, M K

2000-01-01

The most commonly employed techniques for the in vivo measurement of arterial blood flow to individual organs involve the use of flow probes or sensors. Commercially available systems for the measurement of in vivo blood flow can be divided into two categories: ultrasonic and electromagnetic. Two types of ultrasonic probes are used. The first type of flow probe measures blood flow-mediated Doppler shifts (Doppler flowmetry) in a vessel. The second type of flow probe measures the "transit time" required by an emitted ultrasound wave to traverse the vessel and are transit-time volume flow sensors. Measurement of blood flow in any vessel requires that the flow probe or sensor be highly accurate and exhibit signal linearity over the flow range in the vessel of interest. Moreover, additional desirable features include compact design, size, and weight. An additional important feature for flow probes is that they exhibit good biocompatability; it is imperative for the sensor to behave in an inert manner towards the biological system. A sensitive and reliable method to assess blood flow in individual organs in the body, other than by the use of probes/sensors, is the reference sample method that utilizes hematogeneously delivered microspheres. This method has been utilized to a large extend to assess regional blood flow in the entire body. Obviously, the purpose of measuring blood flow is to determine the amount of blood delivered to a given region per unit time (milliliters per minute) and it is desirable to achieve this goal by noninvasive methodologies. This, however, is not always possible. This review attempts to offer an overview of some of the techniques available for the assessment of regional blood flow in the arterial circulatory system and discusses advantages and disadvantages of these common techniques.

METHODS FOR OPTIMIZING URBAN WET-WEATHER CONTROL SYSTEM

EPA Science Inventory

To minimize impacts of urban nonpoint source pollution and associated costs of control (storage and treatment) associated with wet-weather flows (WWFs), stormwater runoff volumes and pollutant loads must be reduced. A number of control strategies, so-called “best management pract...

EPA (ENVIRONMENTAL PROTECTION AGENCY) DESIGN INFORMATION REPORT: SIDESTREAMS IN WASTEWATER TREATMENT PLANTS

EPA Science Inventory

Performance problems at publicly-owned treatment works are often attributed to the recycling of sidestreams generated in the wastewater treatment and sludge handling systems. Although the volumes of these sidestreams are generally small compared to plant influent flows, sidestrea...

Initial testing of a 3D printed perfusion phantom using digital subtraction angiography

NASA Astrophysics Data System (ADS)

Wood, Rachel P.; Khobragade, Parag; Ying, Leslie; Snyder, Kenneth; Wack, David; Bednarek, Daniel R.; Rudin, Stephen; Ionita, Ciprian N.

2015-03-01

Perfusion imaging is the most applied modality for the assessment of acute stroke. Parameters such as Cerebral Blood Flow (CBF), Cerebral Blood volume (CBV) and Mean Transit Time (MTT) are used to distinguish the tissue infarct core and ischemic penumbra. Due to lack of standardization these parameters vary significantly between vendors and software even when provided with the same data set. There is a critical need to standardize the systems and make them more reliable. We have designed a uniform phantom to test and verify the perfusion systems. We implemented a flow loop with different flow rates (250, 300, 350 ml/min) and injected the same amount of contrast. The images of the phantom were acquired using a Digital Angiographic system. Since this phantom is uniform, projection images obtained using DSA is sufficient for initial validation. To validate the phantom we measured the contrast concentration at three regions of interest (arterial input, venous output, perfused area) and derived time density curves (TDC). We then calculated the maximum slope, area under the TDCs and flow. The maximum slope calculations were linearly increasing with increase in flow rate, the area under the curve decreases with increase in flow rate. There was 25% error between the calculated flow and measured flow. The derived TDCs were clinically relevant and the calculated flow, maximum slope and areas under the curve were sensitive to the measured flow. We have created a systematic way to calibrate existing perfusion systems and assess their reliability.

A practical model for pressure probe system response estimation (with review of existing models)

NASA Astrophysics Data System (ADS)

Hall, B. F.; Povey, T.

2018-04-01

The accurate estimation of the unsteady response (bandwidth) of pneumatic pressure probe systems (probe, line and transducer volume) is a common practical problem encountered in the design of aerodynamic experiments. Understanding the bandwidth of the probe system is necessary to capture unsteady flow features accurately. Where traversing probes are used, the desired traverse speed and spatial gradients in the flow dictate the minimum probe system bandwidth required to resolve the flow. Existing approaches for bandwidth estimation are either complex or inaccurate in implementation, so probes are often designed based on experience. Where probe system bandwidth is characterized, it is often done experimentally, requiring careful experimental set-up and analysis. There is a need for a relatively simple but accurate model for estimation of probe system bandwidth. A new model is presented for the accurate estimation of pressure probe bandwidth for simple probes commonly used in wind tunnel environments; experimental validation is provided. An additional, simple graphical method for air is included for convenience.

Broadband Fan Noise Prediction System for Turbofan Engines. Volume 2; BFaNS User's Manual and Developer's Guide

NASA Technical Reports Server (NTRS)

Morin, Bruce L.

2010-01-01

Pratt & Whitney has developed a Broadband Fan Noise Prediction System (BFaNS) for turbofan engines. This system computes the noise generated by turbulence impinging on the leading edges of the fan and fan exit guide vane, and noise generated by boundary-layer turbulence passing over the fan trailing edge. BFaNS has been validated on three fan rigs that were tested during the NASA Advanced Subsonic Technology Program (AST). The predicted noise spectra agreed well with measured data. The predicted effects of fan speed, vane count, and vane sweep also agreed well with measurements. The noise prediction system consists of two computer programs: Setup_BFaNS and BFaNS. Setup_BFaNS converts user-specified geometry and flow-field information into a BFaNS input file. From this input file, BFaNS computes the inlet and aft broadband sound power spectra generated by the fan and FEGV. The output file from BFaNS contains the inlet, aft and total sound power spectra from each noise source. This report is the second volume of a three-volume set documenting the Broadband Fan Noise Prediction System: Volume 1: Setup_BFaNS User s Manual and Developer s Guide; Volume 2: BFaNS User s Manual and Developer s Guide; and Volume 3: Validation and Test Cases. The present volume begins with an overview of the Broadband Fan Noise Prediction System, followed by step-by-step instructions for installing and running BFaNS. It concludes with technical documentation of the BFaNS computer program.

Broadband Fan Noise Prediction System for Turbofan Engines. Volume 1; Setup_BFaNS User's Manual and Developer's Guide

NASA Technical Reports Server (NTRS)

Morin, Bruce L.

2010-01-01

Pratt & Whitney has developed a Broadband Fan Noise Prediction System (BFaNS) for turbofan engines. This system computes the noise generated by turbulence impinging on the leading edges of the fan and fan exit guide vane, and noise generated by boundary-layer turbulence passing over the fan trailing edge. BFaNS has been validated on three fan rigs that were tested during the NASA Advanced Subsonic Technology Program (AST). The predicted noise spectra agreed well with measured data. The predicted effects of fan speed, vane count, and vane sweep also agreed well with measurements. The noise prediction system consists of two computer programs: Setup_BFaNS and BFaNS. Setup_BFaNS converts user-specified geometry and flow-field information into a BFaNS input file. From this input file, BFaNS computes the inlet and aft broadband sound power spectra generated by the fan and FEGV. The output file from BFaNS contains the inlet, aft and total sound power spectra from each noise source. This report is the first volume of a three-volume set documenting the Broadband Fan Noise Prediction System: Volume 1: Setup_BFaNS User s Manual and Developer s Guide; Volume 2: BFaNS User's Manual and Developer s Guide; and Volume 3: Validation and Test Cases. The present volume begins with an overview of the Broadband Fan Noise Prediction System, followed by step-by-step instructions for installing and running Setup_BFaNS. It concludes with technical documentation of the Setup_BFaNS computer program.

Broadband Fan Noise Prediction System for Turbofan Engines. Volume 3; Validation and Test Cases

NASA Technical Reports Server (NTRS)

Morin, Bruce L.

2010-01-01

Pratt & Whitney has developed a Broadband Fan Noise Prediction System (BFaNS) for turbofan engines. This system computes the noise generated by turbulence impinging on the leading edges of the fan and fan exit guide vane, and noise generated by boundary-layer turbulence passing over the fan trailing edge. BFaNS has been validated on three fan rigs that were tested during the NASA Advanced Subsonic Technology Program (AST). The predicted noise spectra agreed well with measured data. The predicted effects of fan speed, vane count, and vane sweep also agreed well with measurements. The noise prediction system consists of two computer programs: Setup_BFaNS and BFaNS. Setup_BFaNS converts user-specified geometry and flow-field information into a BFaNS input file. From this input file, BFaNS computes the inlet and aft broadband sound power spectra generated by the fan and FEGV. The output file from BFaNS contains the inlet, aft and total sound power spectra from each noise source. This report is the third volume of a three-volume set documenting the Broadband Fan Noise Prediction System: Volume 1: Setup_BFaNS User s Manual and Developer s Guide; Volume 2: BFaNS User s Manual and Developer s Guide; and Volume 3: Validation and Test Cases. The present volume begins with an overview of the Broadband Fan Noise Prediction System, followed by validation studies that were done on three fan rigs. It concludes with recommended improvements and additional studies for BFaNS.

Humidification performance of humidifying devices for tracheostomized patients with spontaneous breathing: a bench study.

PubMed

Chikata, Yusuke; Oto, Jun; Onodera, Mutsuo; Nishimura, Masaji

2013-09-01

Heat and moisture exchangers (HMEs) are commonly used for humidifying respiratory gases administered to mechanically ventilated patients. While they are also applied to tracheostomized patients with spontaneous breathing, their performance in this role has not yet been clarified. We carried out a bench study to investigate the effects of spontaneous breathing parameters and oxygen flow on the humidification performance of 11 HMEs. We evaluated the humidification provided by 11 HMEs for tracheostomized patients, and also by a system delivering high-flow CPAP, and an oxygen mask with nebulizer heater. Spontaneous breathing was simulated with a mechanical ventilator, lung model, and servo-controlled heated humidifier at tidal volumes of 300, 500, and 700 mL, and breathing frequencies of 10 and 20 breaths/min. Expired gas was warmed to 37°C. The high-flow CPAP system was set to deliver 15, 30, and 45 L/min. With the 8 HMEs that were equipped with ports to deliver oxygen, and with the high-flow CPAP system, measurements were taken when delivering 0 and 3 L/min of dry oxygen. After stabilization we measured the absolute humidity (AH) of inspired gas with a hygrometer. AH differed among HMEs applied to tracheostomized patients with spontaneous breathing. For all the HMEs, as tidal volume increased, AH decreased. At 20 breaths/min, AH was higher than at 10 breaths/min. For all the HMEs, when oxygen was delivered, AH decreased to below 30 mg/L. With an oxygen mask and high-flow CPAP, at all settings, AH exceeded 30 mg/L. None of the HMEs provided adequate humidification when supplemental oxygen was added. In the ICU, caution is required when applying HME to tracheostomized patients with spontaneous breathing, especially when supplemental oxygen is required.

Mapping debris-flow hazard in Honolulu using a DEM

USGS Publications Warehouse

Ellen, Stephen D.; Mark, Robert K.; ,

1993-01-01

A method for mapping hazard posed by debris flows has been developed and applied to an area near Honolulu, Hawaii. The method uses studies of past debris flows to characterize sites of initiation, volume at initiation, and volume-change behavior during flow. Digital simulations of debris flows based on these characteristics are then routed through a digital elevation model (DEM) to estimate degree of hazard over the area.

Preoperative computer simulation for planning of vascular access surgery in hemodialysis patients.

PubMed

Zonnebeld, Niek; Huberts, Wouter; van Loon, Magda M; Delhaas, Tammo; Tordoir, Jan H M

2017-03-06

The arteriovenous fistula (AVF) is the preferred vascular access for hemodialysis patients. Unfortunately, 20-40% of all constructed AVFs fail to mature (FTM), and are therefore not usable for hemodialysis. AVF maturation importantly depends on postoperative blood volume flow. Predicting patient-specific immediate postoperative flow could therefore support surgical planning. A computational model predicting blood volume flow is available, but the effect of blood flow predictions on the clinical endpoint of maturation (at least 500 mL/min blood volume flow, diameter of the venous cannulation segment ≥4 mm) remains undetermined. A multicenter randomized clinical trial will be conducted in which 372 patients will be randomized (1:1 allocation ratio) between conventional healthcare and computational model-aided decision making. All patients are extensively examined using duplex ultrasonography (DUS) during preoperative assessment (12 venous and 11 arterial diameter measurements; 3 arterial volume flow measurements). The computational model will predict patient-specific immediate postoperative blood volume flows based on this DUS examination. Using these predictions, the preferred AVF configuration is recommended for the individual patient (radiocephalic, brachiocephalic, or brachiobasilic). The primary endpoint is FTM rate at six weeks in both groups, secondary endpoints include AVF functionality and patency rates at 6 and 12 months postoperatively. ClinicalTrials.gov (NCT02453412), and ToetsingOnline.nl (NL51610.068.14).

Efficacy and safety of strategies to preserve stable extracorporeal life support flow during simulated hypovolemia.

PubMed

Simons, A P; Lindelauf, A A M A; Ganushchak, Y M; Maessen, J G; Weerwind, P W

2014-01-01

Without volume-buffering capacity in extracorporeal life support (ELS) systems, hypovolemia can acutely reduce support flow. This study aims at evaluating efficacy and safety of strategies for preserving stable ELS during hypovolemia. Flow and/or pressure-guided servo pump control, a reserve-driven control strategy and a volume buffer capacity (VBC) device were evaluated with respect to pump flow, venous line pressure and arterial gaseous microemboli (GME) during simulated normovolemia and hypovolemia. Normovolemia resulted in a GME-free pump flow of 3.1 ± 0.0 L/min and a venous line pressure of -10 ± 1 mmHg. Hypovolemia without servo pump control resulted in a GME-loaded flow of 2.3 ± 0.4 L/min with a venous line pressure of -114 ± 52 mmHg. Servo control resulted in an unstable and GME-loaded flow of 1.5 ± 1.2 L/min. With and without servo pump control, the VBC device stabilised flow (SD = 0.2 and 0.0 L/min, respectively) and venous line pressure (SD=51 and 4 mmHg, respectively) with near-absent GME activity. Reserve-driven pump control combined with a VBC device restored a near GME-free flow of 2.7 ± 0.0 L/min with a venous line pressure of -9 ± 0 mmHg. In contrast to a reserve-driven pump control strategy combined with a VBC device, flow and pressure servo control for ELS show evident deficits in preserving stable and safe ELS flow during hypovolemia.

A multicomponent tracer field experiment to measure the flow volume, surface area, and rectilinear spacing of fractures away from the wellbore

NASA Astrophysics Data System (ADS)

Cathles, L. M.; Sanford, W. E.; Hawkins, A.; Li, Y. V.

2017-12-01

The nature of flow in fractured porous media is important to almost all subsurface processes including oil and gas recovery, contaminant transport and remediation, CO2 sequestration, and geothermal heat extraction. One would like to know, under flowing conditions, the flow volume, surface area, effective aperture, and rectilinear spacing of fractures in a representative volume of rock away from the well bore, but no methods currently allow acquisition of this data. It could, however, be collected by deploying inert tracers with a wide range of aqueous diffusion constants (e.g., rapidly diffusing heat to non-diffusing nanoparticle) in the following fashion: The flow volume is defined by the heated volume measured by resistivity surveys. The fracture volume within this flow volume is indicate by the nanoparticle transit time. The average fracture spacing is indicated by the evolving thermal profile in the monitor and the production wells (measured by fiber optic cable), and by the retention of absorbing tracers. The average fracture aperture is determined by permeability measurements and the average fracture separation. We have proposed a field test to redundantly measure these fracture parameters in the fractured Dakota Sandstone where it approaches the surface in Ft Collins, Colorado. Five 30 m deep wells (an injection, production, and 3 monitor wells) cased to 20 m are proposed. The experiments will involve at least 9 different tracers. The planned field test and its potential significance will be described.

The computational structural mechanics testbed architecture. Volume 2: The interface

NASA Technical Reports Server (NTRS)

Felippa, Carlos A.

1988-01-01

This is the third set of five volumes which describe the software architecture for the Computational Structural Mechanics Testbed. Derived from NICE, an integrated software system developed at Lockheed Palo Alto Research Laboratory, the architecture is composed of the command language CLAMP, the command language interpreter CLIP, and the data manager GAL. Volumes 1, 2, and 3 (NASA CR's 178384, 178385, and 178386, respectively) describe CLAMP and CLIP and the CLIP-processor interface. Volumes 4 and 5 (NASA CR's 178387 and 178388, respectively) describe GAL and its low-level I/O. CLAMP, an acronym for Command Language for Applied Mechanics Processors, is designed to control the flow of execution of processors written for NICE. Volume 3 describes the CLIP-Processor interface and related topics. It is intended only for processor developers.

The computational structural mechanics testbed architecture. Volume 1: The language

NASA Technical Reports Server (NTRS)

Felippa, Carlos A.

1988-01-01

This is the first set of five volumes which describe the software architecture for the Computational Structural Mechanics Testbed. Derived from NICE, an integrated software system developed at Lockheed Palo Alto Research Laboratory, the architecture is composed of the command language CLAMP, the command language interpreter CLIP, and the data manager GAL. Volumes 1, 2, and 3 (NASA CR's 178384, 178385, and 178386, respectively) describe CLAMP and CLIP, and the CLIP-processor interface. Volumes 4 and 5 (NASA CR's 178387 and 178388, respectively) describe GAL and its low-level I/O. CLAMP, an acronym for Command Language for Applied Mechanics Processors, is designed to control the flow of execution of processors written for NICE. Volume 1 presents the basic elements of the CLAMP language and is intended for all users.

The computational structural mechanics testbed architecture. Volume 2: Directives

NASA Technical Reports Server (NTRS)

Felippa, Carlos A.

1989-01-01

This is the second of a set of five volumes which describe the software architecture for the Computational Structural Mechanics Testbed. Derived from NICE, an integrated software system developed at Lockheed Palo Alto Research Laboratory, the architecture is composed of the command language (CLAMP), the command language interpreter (CLIP), and the data manager (GAL). Volumes 1, 2, and 3 (NASA CR's 178384, 178385, and 178386, respectively) describe CLAMP and CLIP and the CLIP-processor interface. Volumes 4 and 5 (NASA CR's 178387 and 178388, respectively) describe GAL and its low-level I/O. CLAMP, an acronym for Command Language for Applied Mechanics Processors, is designed to control the flow of execution of processors written for NICE. Volume 2 describes the CLIP directives in detail. It is intended for intermediate and advanced users.

Use of body plethysmography to measure effect of bimaxillary orthognathic surgery on airway resistance and lung volumes.

PubMed

Rezaeetalab, Fariba; Kazemian, Mozhgan; Vaezi, Touraj; Shaban, Barratollah

2015-12-01

Bimaxillary orthognathic surgery can cause changes to respiration and the airways. We used body plethysmography to evaluate its effect on airway resistance and lung volumes in 20 patients with class III malocclusions (8 men and 12 women, aged 17 - 32 years). Lung volumes (forced vital capacity; forced inspiratory volume/one second; forced expiratory volume/one second: forced vital capacity; peak expiratory flow; maximum expiratory flow 25-75; maximum inspiratory flow; total lung capacity; residual volume; residual volume:total lung capacity), and airway resistance were evaluated one week before, and six months after, operation. Bimaxillary operations to correct class III malocclusions significantly increased airway resistance, residual volume, total lung capacity, and residual volume:total lung capacity. Other variables also changed after operation but not significantly so. Orthognathic operations should be done with caution in patients who have pre-existing respiratory diseases. Copyright © 2015 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

Volume Oscillations Delivered to a Lung Model Using 4 Different Bubble CPAP Systems.

PubMed

Poli, Jonathan A; Richardson, C Peter; DiBlasi, Robert M

2015-03-01

High-frequency pressure oscillations created by gas bubbling through an underwater seal during bubble CPAP may enhance ventilation and aid in lung recruitment in premature infants. We hypothesized that there are no differences in the magnitude of oscillations in lung volume (ΔV) in a preterm neonatal lung model when different bubble CPAP systems are used. An anatomically realistic replica of an infant nasal airway model was attached to a Silastic test lung sealed within a calibrated plethysmograph. Nasal prongs were affixed to the simulated neonate and supported using bubble CPAP systems set at 6 cm H2O. ΔV was calculated using pressure measurements obtained from the plethysmograph. The Fisher & Paykel Healthcare bubble CPAP system provided greater ΔV than any of the other devices at all of the respective bias flows (P < .05). The Fisher & Paykel Healthcare and Babi.Plus systems generally provided ΔV at lower frequencies than the other bubble CPAP systems. The magnitude of ΔV increased at bias flows of > 4 L/min in the Fisher & Paykel Healthcare, Airways Development, and homemade systems, but appeared to decrease as bias flow increased with the Babi.Plus system. The major finding of this study is that bubble CPAP can provide measureable ventilation effects in an infant lung model. We speculate that the differences noted in ΔV between the different devices are a combination of the circuit/nasal prong configuration, bubbler configuration, and frequency of oscillations. Additional testing is needed in spontaneously breathing infants to determine whether a physiologic benefit exists when using the different bubble CPAP systems. Copyright © 2015 by Daedalus Enterprises.

Interactive simulation system for artificial ventilation on the internet: virtual ventilator.

PubMed

Takeuchi, Akihiro; Abe, Tadashi; Hirose, Minoru; Kamioka, Koichi; Hamada, Atsushi; Ikeda, Noriaki

2004-12-01

To develop an interactive simulation system "virtual ventilator" that demonstrates the dynamics of pressure and flow in the respiratory system under the combination of spontaneous breathing, ventilation modes, and ventilator options. The simulation system was designed to be used by unexperienced health care professionals as a self-training tool. The system consists of a simulation controller and three modules: respiratory, spontaneous breath, and ventilator. The respiratory module models the respiratory system by three resistances representing the main airway, the right and left lungs, and two compliances also representing the right and left lungs. The spontaneous breath module generates inspiratory negative pressure produced by a patient. The ventilator module generates driving force of pressure or flow according to the combination of the ventilation mode and options. These forces are given to the respiratory module through the simulation controller. The simulation system was developed using HTML, VBScript (3000 lines, 100 kB) and ActiveX control (120 kB), and runs on Internet Explorer (5.5 or higher). The spontaneous breath is defined by a frequency, amplitude and inspiratory patterns in the spontaneous breath module. The user can construct a ventilation mode by setting a control variable, phase variables (trigger, limit, and cycle), and options. Available ventilation modes are: controlled mechanical ventilation (CMV), continuous positive airway pressure, synchronized intermittent mandatory ventilation (SIMV), pressure support ventilation (PSV), SIMV + PSV, pressure-controlled ventilation (PCV), pressure-regulated volume control (PRVC), proportional assisted ventilation, mandatory minute ventilation (MMV), bilevel positive airway pressure (BiPAP). The simulation system demonstrates in a graph and animation the airway pressure, flow, and volume of the respiratory system during mechanical ventilation both with and without spontaneous breathing. We developed a web application that demonstrated the respiratory mechanics and the basic theory of ventilation mode.

Development of standardized air-blown coal gasifier/gas turbine concepts for future electric power systems, Volume 4

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1991-02-01

This appendix is a compilation of work done to predict overall cycle performance from gasifier to generator terminals. A spreadsheet has been generated for each case to show flows within a cycle. The spreadsheet shows gaseous or solid composition of flow, temperature of flow, quantity of flow, and heat heat content of flow. Prediction of steam and gas turbine performance was obtained by the computer program GTPro. Outputs of all runs for each combined cycle reviewed has been added to this appendix. A process schematic displaying all flows predicted through GTPro and the spreadsheet is also added to this appendix.more » The numbered bubbles on the schematic correspond to columns on the top headings of the spreadsheet.« less

A calculation procedure for viscous flow in turbomachines, volume 2

NASA Technical Reports Server (NTRS)

Khalil, J.; Tabakoff, W.

1980-01-01

Turbulent flow within turbomachines having arbitrary blade geometries is examined. Effects of turbulence are modeled using two equations, one expressing the development of the turbulence kinetic energy and the other its dissipation rate. To account for complicated blade geometries, the flow equations are formulated in terms of a nonorthogonal boundary fitted coordinate system. The analysis is applied to a radial inflow turbine. The solution obtained indicates the severity of the complex interaction mechanism that occurs between the different flow regimes (i.e., boundary layers, recirculating eddies, separation zones, etc.). Comparison with nonviscous flow solutions tend to justify strongly the inadequacy of using the latter with standard boundary layer techniques to obtain viscous flow details within turbomachine rotors. Capabilities and limitations of the present method of analysis are discussed.

Coupled Finite Volume and Finite Element Method Analysis of a Complex Large-Span Roof Structure

NASA Astrophysics Data System (ADS)

Szafran, J.; Juszczyk, K.; Kamiński, M.

2017-12-01

The main goal of this paper is to present coupled Computational Fluid Dynamics and structural analysis for the precise determination of wind impact on internal forces and deformations of structural elements of a longspan roof structure. The Finite Volume Method (FVM) serves for a solution of the fluid flow problem to model the air flow around the structure, whose results are applied in turn as the boundary tractions in the Finite Element Method problem structural solution for the linear elastostatics with small deformations. The first part is carried out with the use of ANSYS 15.0 computer system, whereas the FEM system Robot supports stress analysis in particular roof members. A comparison of the wind pressure distribution throughout the roof surface shows some differences with respect to that available in the engineering designing codes like Eurocode, which deserves separate further numerical studies. Coupling of these two separate numerical techniques appears to be promising in view of future computational models of stochastic nature in large scale structural systems due to the stochastic perturbation method.

Evaluation of Variable Refrigerant Flow Systems Performance on Oak Ridge National Laboratory s Flexible Research Platform: Part 1 Cooling Season Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Im, Piljae; Malhotra, Mini; Munk, Jeffrey D.

This report provides second-year cooling season test results for the multi-year project titled “Evaluation of Variable Refrigeration Flow (VRF) System on Oak Ridge National Laboratory (ORNL)’s Flexible Research Platform (FRP).” The purpose of the second-year project was to (1) evaluate the full- and partload performance of VRF systems compared with an existing baseline heating, ventilation, and airconditioning (HVAC) system, which is a conventional rooftop unit (RTU) variable-air-volume (VAV) system with electric resistance heating and (2) use hourly building energy simulation to evaluate the energy savings potential of using VRF systems in major US cities. The second-year project performance period wasmore » from July 2015 through June 2016.« less

Glottal volume velocity waveform characteristics in subjects with and without vocal training, related to gender, sound intensity, fundamental frequency, and age.

PubMed

Sulter, A M; Wit, H P

1996-11-01

Glottal volume velocity waveform characteristics of 224 subjects, categorized in four groups according to gender and vocal training, were determined, and their relations to sound-pressure level, fundamental frequency, intra-oral pressure, and age were analyzed. Subjects phonated at three intensity conditions. The glottal volume velocity waveforms were obtained by inverse filtering the oral flow. Glottal volume velocity waveforms were parameterized with flow-based (minimum flow, ac flow, average flow, maximum flow declination rate) and time-based parameters (closed quotient, closing quotient, speed quotient), as well as with derived parameters (vocal efficiency and glottal resistance). Higher sound-pressure levels, intra-oral pressures, and flow-parameter values (ac flow, maximum flow declination rate) were observed, when compared with previous investigations. These higher values might be the result of the specific phonation tasks (stressed /ae/ vowel in a word and a sentence) or filtering processes. Few statistically significant (p < 0.01) differences in parameters were found between untrained and trained subjects [the maximum flow declination rate and the closing quotient were higher in trained women (p < 0.001), and the speed quotient was higher in trained men (p < 0.005)]. Several statistically significant parameter differences were found between men and women [minimum flow, ac flow, average flow, maximum flow declination rate, closing quotient, glottal resistance (p < 0.001), and closed quotient (p < 0.005)]. Significant effects of intensity condition were observed on ac flow, maximum flow declination rate, closing quotient, and vocal efficiency in women (p < 0.005), and on minimum flow, ac flow, average flow, maximum flow declination rate, closed quotient, and vocal efficiency in men (p < 0.01).