Engineering Fracking Fluids with Computer Simulation

NASA Astrophysics Data System (ADS)

Shaqfeh, Eric

2015-11-01

There are no comprehensive simulation-based tools for engineering the flows of viscoelastic fluid-particle suspensions in fully three-dimensional geometries. On the other hand, the need for such a tool in engineering applications is immense. Suspensions of rigid particles in viscoelastic fluids play key roles in many energy applications. For example, in oil drilling the ``drilling mud'' is a very viscous, viscoelastic fluid designed to shear-thin during drilling, but thicken at stoppage so that the ``cuttings'' can remain suspended. In a related application known as hydraulic fracturing suspensions of solids called ``proppant'' are used to prop open the fracture by pumping them into the well. It is well-known that particle flow and settling in a viscoelastic fluid can be quite different from that which is observed in Newtonian fluids. First, it is now well known that the ``fluid particle split'' at bifurcation cracks is controlled by fluid rheology in a manner that is not understood. Second, in Newtonian fluids, the presence of an imposed shear flow in the direction perpendicular to gravity (which we term a cross or orthogonal shear flow) has no effect on the settling of a spherical particle in Stokes flow (i.e. at vanishingly small Reynolds number). By contrast, in a non-Newtonian liquid, the complex rheological properties induce a nonlinear coupling between the sedimentation and shear flow. Recent experimental data have shown both the shear thinning and the elasticity of the suspending polymeric solutions significantly affects the fluid-particle split at bifurcations, as well as the settling rate of the solids. In the present work, we use the Immersed Boundary Method to develop computer simulations of viscoelastic flow in suspensions of spheres to study these problems. These simulations allow us to understand the detailed physical mechanisms for the remarkable physical behavior seen in practice, and actually suggest design rules for creating new fluid recipes.

Deformation of a Capsule in a Power-Law Shear Flow

PubMed Central

2016-01-01

An immersed boundary-lattice Boltzmann method is developed for fluid-structure interactions involving non-Newtonian fluids (e.g., power-law fluid). In this method, the flexible structure (e.g., capsule) dynamics and the fluid dynamics are coupled by using the immersed boundary method. The incompressible viscous power-law fluid motion is obtained by solving the lattice Boltzmann equation. The non-Newtonian rheology is achieved by using a shear rate-dependant relaxation time in the lattice Boltzmann method. The non-Newtonian flow solver is then validated by considering a power-law flow in a straight channel which is one of the benchmark problems to validate an in-house solver. The numerical results present a good agreement with the analytical solutions for various values of power-law index. Finally, we apply this method to study the deformation of a capsule in a power-law shear flow by varying the Reynolds number from 0.025 to 0.1, dimensionless shear rate from 0.004 to 0.1, and power-law index from 0.2 to 1.8. It is found that the deformation of the capsule increases with the power-law index for different Reynolds numbers and nondimensional shear rates. In addition, the Reynolds number does not have significant effect on the capsule deformation in the flow regime considered. Moreover, the power-law index effect is stronger for larger dimensionless shear rate compared to smaller values. PMID:27840656

Disturbed flow mediated modulation of shear forces on endothelial plane: A proposed model for studying endothelium around atherosclerotic plaques

NASA Astrophysics Data System (ADS)

Balaguru, Uma Maheswari; Sundaresan, Lakshmikirupa; Manivannan, Jeganathan; Majunathan, Reji; Mani, Krishnapriya; Swaminathan, Akila; Venkatesan, Saravanakumar; Kasiviswanathan, Dharanibalan; Chatterjee, Suvro

2016-06-01

Disturbed fluid flow or modulated shear stress is associated with vascular conditions such as atherosclerosis, thrombosis, and aneurysm. In vitro simulation of the fluid flow around the plaque micro-environment remains a challenging approach. Currently available models have limitations such as complications in protocols, high cost, incompetence of co-culture and not being suitable for massive expression studies. Hence, the present study aimed to develop a simple, versatile model based on Computational Fluid Dynamics (CFD) simulation. Current observations of CFD have shown the regions of modulated shear stress by the disturbed fluid flow. To execute and validate the model in real sense, cell morphology, cytoskeletal arrangement, cell death, reactive oxygen species (ROS) profile, nitric oxide production and disturbed flow markers under the above condition were assessed. Endothelium at disturbed flow region which had been exposed to low shear stress and swirling flow pattern showed morphological and expression similarities with the pathological disturbed flow environment reported previously. Altogether, the proposed model can serve as a platform to simulate the real time micro-environment of disturbed flow associated with eccentric plaque shapes and the possibilities of studying its downstream events.

Microstructural evolution of a model, shear-banding micellar solution during shear startup and cessation.

PubMed

López-Barrón, Carlos R; Gurnon, A Kate; Eberle, Aaron P R; Porcar, Lionel; Wagner, Norman J

2014-04-01

We present direct measurements of the evolution of the segmental-level microstructure of a stable shear-banding polymerlike micelle solution during flow startup and cessation in the plane of flow. These measurements provide a definitive, quantitative microstructural understanding of the stages observed during flow startup: an initial elastic response with limited alignment that yields with a large stress overshoot to a homogeneous flow with associated micellar alignment that persists for approximately three relaxation times. This transient is followed by a shear (kink) band formation with a flow-aligned low-viscosity band that exhibits shear-induced concentration fluctuations and coexists with a nearly isotropic band of homogenous, highly viscoelastic micellar solution. Stable, steady banding flow is achieved only after approximately two reptation times. Flow cessation from this shear-banded state is also found to be nontrivial, exhibiting an initial fast relaxation with only minor structural relaxation, followed by a slower relaxation of the aligned micellar fluid with the equilibrium fluid's characteristic relaxation time. These measurements resolve a controversy in the literature surrounding the mechanism of shear banding in entangled wormlike micelles and, by means of comparison to existing literature, provide further insights into the mechanisms driving shear-banding instabilities in related systems. The methods and instrumentation described should find broad use in exploring complex fluid rheology and testing microstructure-based constitutive equations.

Experimental evidence of symmetry-breaking supercritical transition in pipe flow of shear-thinning fluids

NASA Astrophysics Data System (ADS)

Wen, Chaofan; Poole, Robert J.; Willis, Ashley P.; Dennis, David J. C.

2017-03-01

Experimental results reveal that the asymmetric flow of shear-thinning fluid through a cylindrical pipe, which was previously associated with the laminar-turbulent transition process, appears to have the characteristics of a nonhysteretic, supercritical instability of the laminar base state. Contrary to what was previously believed, classical transition is found to be responsible for returning symmetry to the flow. An absence of evidence of the instability in simulations (either linear or nonlinear) suggests that an element of physics is lacking in the commonly used rheological model for inelastic shear-thinning fluids. These unexpected discoveries raise new questions regarding the stability of these practically important fluids and how they can be successfully modeled.

Numerical simulation of a shear-thinning fluid through packed spheres

NASA Astrophysics Data System (ADS)

Liu, Hai Long; Moon, Jong Sin; Hwang, Wook Ryol

2012-12-01

Flow behaviors of a non-Newtonian fluid in spherical microstructures have been studied by a direct numerical simulation. A shear-thinning (power-law) fluid through both regular and randomly packed spheres has been numerically investigated in a representative unit cell with the tri-periodic boundary condition, employing a rigorous three-dimensional finite-element scheme combined with fictitious-domain mortar-element methods. The present scheme has been validated for the classical spherical packing problems with literatures. The flow mobility of regular packing structures, including simple cubic (SC), body-centered cubic (BCC), face-centered cubic (FCC), as well as randomly packed spheres, has been investigated quantitatively by considering the amount of shear-thinning, the pressure gradient and the porosity as parameters. Furthermore, the mechanism leading to the main flow path in a highly shear-thinning fluid through randomly packed spheres has been discussed.

Temporal gradients in shear stimulate osteoblastic proliferation via ERK1/2 and retinoblastoma protein

NASA Technical Reports Server (NTRS)

Jiang, Guang-Liang; White, Charles R.; Stevens, Hazel Y.; Frangos, John A.

2002-01-01

Bone cells are subject to interstitial fluid flow (IFF) driven by venous pressure and mechanical loading. Rapid dynamic changes in mechanical loading cause transient gradients in IFF. The effects of pulsatile flow (temporal gradients in fluid shear) on rat UMR106 cells and rat primary osteoblastic cells were studied. Pulsatile flow induced a 95% increase in S-phase UMR106 cells compared with static controls. In contrast, ramped steady flow stimulated only a 3% increase. Similar patterns of S-phase induction were also observed in rat primary osteoblastic cells. Pulsatile flow significantly increased relative UMR106 cell number by 37 and 62% at 1.5 and 24 h, respectively. Pulsatile flow also significantly increased extracellular signal-regulated kinase (ERK1/2) phosphorylation by 418%, whereas ramped steady flow reduced ERK1/2 activation to 17% of control. Correspondingly, retinoblastoma protein was significantly phosphorylated by pulsatile fluid flow. Inhibition of mitogen-activated protein (MAP)/ERK kinase (MEK)1/2 by U0126 (a specific MEK1/2 inhibitor) reduced shear-induced ERK1/2 phosphorylation and cell proliferation. These findings suggest that temporal gradients in fluid shear stress are potent stimuli of bone cell proliferation.

Research on wall shear stress considering wall roughness when shear swirling flow vibration cementing

NASA Astrophysics Data System (ADS)

Cui, Zhihua; Ai, Chi; Feng, Fuping

2017-01-01

When shear swirling flow vibration cementing, the casing is revolving periodically and eccentrically, which leads to the annulus fluid in turbulent swirling flow state. The wall shear stress is more than that in laminar flow field when conventional cementing. The paper mainly studied the wall shear stress distribution on the borehole wall when shear swirling flow vibration cementing based on the finite volume method. At the same time, the wall roughness affected and changed the turbulent flow near the borehole wall and the wall shear stress. Based on the wall function method, the paper established boundary conditions considering the wall roughness and derived the formula of the wall shear stress. The results showed that the wall roughness significantly increases the wall shear stress. However, the larger the wall roughness, the greater the thickness of mud cake, which weakening the cementing strength. Considering the effects in a comprehensive way, it is discovered that the particle size of solid phase in drilling fluid is about 0.1 mm to get better cementing quality.

On the connection between Maximum Drag Reduction and Newtonian fluid flow

NASA Astrophysics Data System (ADS)

Whalley, Richard; Park, Jae-Sung; Kushwaha, Anubhav; Dennis, David; Graham, Michael; Poole, Robert

2014-11-01

To date, the most successful turbulence control technique is the dissolution of certain rheology-modifying additives in liquid flows, which results in a universal maximum drag reduction (MDR) asymptote. The MDR asymptote is a well-known phenomenon in the turbulent flow of complex fluids; yet recent direct numerical simulations of Newtonian fluid flow have identified time intervals showing key features of MDR. These intervals have been termed ``hibernating turbulence'' and are a weak turbulence state which is characterised by low wall-shear stress and weak vortical flow structures. Here, in this experimental investigation, we monitor the instantaneous wall-shear stress in a fully-developed turbulent channel flow of a Newtonian fluid with a hot-film probe whilst simultaneously measuring the streamwise velocity at various distances above the wall with laser Doppler velocimetry. We show, by conditionally sampling the streamwise velocity during low wall-shear stress events, that the MDR velocity profile is approached in an additive-free, Newtonian fluid flow. This result corroborates recent numerical investigations, which suggest that the MDR asymptote in polymer solutions is closely connected to weak, transient Newtonian flow structures.

Gravity-Driven Thin Film Flow of an Ellis Fluid.

PubMed

Kheyfets, Vitaly O; Kieweg, Sarah L

2013-12-01

The thin film lubrication approximation has been studied extensively for moving contact lines of Newtonian fluids. However, many industrial and biological applications of the thin film equation involve shear-thinning fluids, which often also exhibit a Newtonian plateau at low shear. This study presents new numerical simulations of the three-dimensional (i.e. two-dimensional spreading), constant-volume, gravity-driven, free surface flow of an Ellis fluid. The numerical solution was validated with a new similarity solution, compared to previous experiments, and then used in a parametric study. The parametric study centered around rheological data for an example biological application of thin film flow: topical drug delivery of anti-HIV microbicide formulations, e.g. hydroxyethylcellulose (HEC) polymer solutions. The parametric study evaluated how spreading length and front velocity saturation depend on Ellis parameters. A lower concentration polymer solution with smaller zero shear viscosity ( η 0 ), τ 1/2 , and λ values spread further. However, when comparing any two fluids with any possible combinations of Ellis parameters, the impact of changing one parameter on spreading length depends on the direction and magnitude of changes in the other two parameters. In addition, the isolated effect of the shear-thinning parameter, λ , on the front velocity saturation depended on τ 1/2 . This study highlighted the relative effects of the individual Ellis parameters, and showed that the shear rates in this flow were in both the shear-thinning and plateau regions of rheological behavior, emphasizing the importance of characterizing the full range of shear-rates in rheological measurements. The validated numerical model and parametric study provides a useful tool for future steps to optimize flow of a fluid with rheological behavior well-described by the Ellis constitutive model, in a range of industrial and biological applications.

The importance of flow history in mixed shear and extensional flows

NASA Astrophysics Data System (ADS)

Wagner, Caroline; McKinley, Gareth

2015-11-01

Many complex fluid flows of experimental and academic interest exhibit mixed kinematics with regions of shear and elongation. Examples include flows through planar hyperbolic contractions in microfluidic devices and through porous media or geometric arrays. Through the introduction of a ``flow-type parameter'' α which varies between 0 in pure shear and 1 in pure elongation, the local velocity fields of all such mixed flows can be concisely characterized. It is tempting to then consider the local stress field and interpret the local state of stress in a complex fluid in terms of shearing or extensional material functions. However, the material response of such fluids exhibit a fading memory of the entire deformation history. We consider a dilute solution of Hookean dumbbells and solve the Oldroyd-B model to obtain analytic expressions for the entire stress field in any arbitrary mixed flow of constant strain rate and flow-type parameter α. We then consider a more complex flow for which the shear rate is constant but the flow-type parameter α varies periodically in time (reminiscent of flow through a periodic array or through repeated contractions and expansions). We show that the flow history and kinematic sequencing (in terms of whether the flow was initialized as shearing or extensional) is extremely important in determining the ensuing stress field and rate of dissipated energy in the flow, and can only be ignored in the limit of infinitely slow flow variations.

Investigation of the fluid flow dynamic parameters for Newtonian and non-Newtonian materials: an approach to understanding the fluid flow-like structures within fault zones

NASA Astrophysics Data System (ADS)

Tanaka, H.; Shiomi, Y.; Ma, K.-F.

2017-11-01

To understand the fault zone fluid flow-like structure, namely the ductile deformation structure, often observed in the geological field (e.g., Ramsay and Huber The techniques of modern structure geology, vol. 1: strain analysis, Academia Press, London, 1983; Hobbs and Ord Structure geology: the mechanics of deforming metamorphic rocks, Vol. I: principles, Elsevier, Amsterdam, 2015), we applied a theoretical approach to estimate the rate of deformation, the shear stress and the time to form a streak-line pattern in the boundary layer of viscous fluids. We model the dynamics of streak lines in laminar boundary layers for Newtonian and pseudoplastic fluids and compare the results to those obtained via laboratory experiments. The structure of deformed streak lines obtained using our model is consistent with experimental observations, indicating that our model is appropriate for understanding the shear rate, flow time and shear stress based on the profile of deformed streak lines in the boundary layer in Newtonian and pseudoplastic viscous materials. This study improves our understanding of the transportation processes in fluids and of the transformation processes in fluid-like materials. Further application of this model could facilitate understanding the shear stress and time history of the fluid flow-like structure of fault zones observed in the field.[Figure not available: see fulltext.

Unified description of the slip phenomena in sheared polymer films: A molecular dynamics study

NASA Astrophysics Data System (ADS)

Priezjev, Nikolai

2010-03-01

The dynamic behavior of the slip length in shear flow of polymer melts past atomically smooth surfaces is investigated using MD simulations. The polymer melt was modeled as a collection of FENE-LJ bead-spring chains. We consider shear flow conditions at low pressures and weak wall-fluid interaction energy so that fluid velocity profiles are linear throughout the channel at all shear rates examined. In agreement with earlier studies we confirm that for shear- thinning fluids the slip length passes through a local minimum at low shear rates and then increases rapidly at higher shear rates. We found that the rate dependence of the slip length depends on the lattice orientation at high shear rates. The MD results show that the ratio of slip length to viscosity follows a master curve when plotted as a function of a single variable that depends on the structure factor, contact density and temperature of the first fluid layer near the solid wall. The universal dependence of the slip length holds for a number of parameters of the interface: fluid density and structure (chain length), wall-fluid interaction energy, wall density, lattice orientation, thermal or solid walls.

Growth of viscoelastic wings and the reduction of particle mobility in a viscoelastic shear flow

NASA Astrophysics Data System (ADS)

Murch, William L.; Krishnan, Sreenath; Shaqfeh, Eric S. G.; Iaccarino, Gianluca

2017-10-01

The motion of a rigid spherical particle in a sheared polymeric fluid is studied via experiments and numerical simulations. We study particle mobility in highly elastic fluids, where the deformation due to the sphere's movement and the shear flow both result in significant stretching of the polymer. The shear flow is imposed in a plane perpendicular to the sphere's movement, resulting in regions of high polymer tension in the wake of the sphere that can extend well into the shear flow and gradient directions. We observe that these viscoelastic wake structures, resembling wings, are linked to an increase in the form drag, providing a mechanism for a dramatic decrease in the particle mobility.

Oscillatory motion based measurement method and sensor for measuring wall shear stress due to fluid flow

DOEpatents

Armstrong, William D [Laramie, WY; Naughton, Jonathan [Laramie, WY; Lindberg, William R [Laramie, WY

2008-09-02

A shear stress sensor for measuring fluid wall shear stress on a test surface is provided. The wall shear stress sensor is comprised of an active sensing surface and a sensor body. An elastic mechanism mounted between the active sensing surface and the sensor body allows movement between the active sensing surface and the sensor body. A driving mechanism forces the shear stress sensor to oscillate. A measuring mechanism measures displacement of the active sensing surface relative to the sensor body. The sensor may be operated under periodic excitation where changes in the nature of the fluid properties or the fluid flow over the sensor measurably changes the amplitude or phase of the motion of the active sensing surface, or changes the force and power required from a control system in order to maintain constant motion. The device may be operated under non-periodic excitation where changes in the nature of the fluid properties or the fluid flow over the sensor change the transient motion of the active sensor surface or change the force and power required from a control system to maintain a specified transient motion of the active sensor surface.

Microfluidic viscometers for shear rheology of complex fluids and biofluids

PubMed Central

Wang, William S.; Vanapalli, Siva A.

2016-01-01

The rich diversity of man-made complex fluids and naturally occurring biofluids is opening up new opportunities for investigating their flow behavior and characterizing their rheological properties. Steady shear viscosity is undoubtedly the most widely characterized material property of these fluids. Although widely adopted, macroscale rheometers are limited by sample volumes, access to high shear rates, hydrodynamic instabilities, and interfacial artifacts. Currently, microfluidic devices are capable of handling low sample volumes, providing precision control of flow and channel geometry, enabling a high degree of multiplexing and automation, and integrating flow visualization and optical techniques. These intrinsic advantages of microfluidics have made it especially suitable for the steady shear rheology of complex fluids. In this paper, we review the use of microfluidics for conducting shear viscometry of complex fluids and biofluids with a focus on viscosity curves as a function of shear rate. We discuss the physical principles underlying different microfluidic viscometers, their unique features and limits of operation. This compilation of technological options will potentially serve in promoting the benefits of microfluidic viscometry along with evincing further interest and research in this area. We intend that this review will aid researchers handling and studying complex fluids in selecting and adopting microfluidic viscometers based on their needs. We conclude with challenges and future directions in microfluidic rheometry of complex fluids and biofluids. PMID:27478521

GPU accelerated simulations of three-dimensional flow of power-law fluids in a driven cube

NASA Astrophysics Data System (ADS)

Jin, K.; Vanka, S. P.; Agarwal, R. K.; Thomas, B. G.

2017-01-01

Newtonian fluid flow in two- and three-dimensional cavities with a moving wall has been studied extensively in a number of previous works. However, relatively a fewer number of studies have considered the motion of non-Newtonian fluids such as shear thinning and shear thickening power law fluids. In this paper, we have simulated the three-dimensional, non-Newtonian flow of a power law fluid in a cubic cavity driven by shear from the top wall. We have used an in-house developed fractional step code, implemented on a Graphics Processor Unit. Three Reynolds numbers have been studied with power law index set to 0.5, 1.0 and 1.5. The flow patterns, viscosity distributions and velocity profiles are presented for Reynolds numbers of 100, 400 and 1000. All three Reynolds numbers are found to yield steady state flows. Tabulated values of velocity are given for the nine cases studied, including the Newtonian cases.

On turbulence decay of a shear-thinning fluid

NASA Astrophysics Data System (ADS)

Rahgozar, S.; Rival, D. E.

2017-12-01

An experimental investigation of turbulent flow in a shear-thinning fluid is presented. The experimental flow is a boundary-free, uniformly sheared flow at a relatively high Reynolds number (i.e., Re λmax=275 ), which decays in time. As just one example of decaying turbulence, the experiment can be thought of as a simple model of bulk turbulence in large arteries. The dimensionless parameters used are Reynolds, Strouhal, and Womersley numbers, which have been adapted according to the characteristics of the present experiment. The working fluid is a solution of aqueous 35 ppm xanthan gum, a well-known shear-thinning fluid. The velocity fields are acquired via time-resolved particle image velocimetry in the streamwise/cross-stream and streamwise/spanwise planes. The results show that the presence of xanthan gum not only modifies the turbulent kinetic energy and the dissipation rate but also significantly alters the characteristics of the large-scale eddies.

Quantification and significance of fluid shear stress field in biaxial cell stretching device.

PubMed

Thompson, Mark S; Abercrombie, Stuart R; Ott, Claus-Eric; Bieler, Friederike H; Duda, Georg N; Ventikos, Yiannis

2011-07-01

A widely used commercially available system for the investigation of mechanosensitivity applies a biaxial strain field to cells cultured on a compliant silicone substrate membrane stretched over a central post. As well as intended substrate strain, this device also provides a fluid flow environment for the cultured cells. In order to interpret the relevance of experiments using this device to the in vivo and clinical situation, it is essential to characterise both substrate and fluid environments. While previous work has detailed the substrate strain, the fluid shear stresses, to which bone cells are known to be sensitive, are unknown. Therefore, a fluid structure interaction computational fluid dynamics model was constructed, incorporating a finite element technique capable of capturing the contact between the post and the silicone substrate membrane, to the underside of which the pump control pressure was applied. Flow verification experiments using 10-μm-diameter fluorescent microspheres were carried out. Fluid shear stress increased approximately linearly with radius along the on-post substrate membrane, with peak values located close to the post edge. Changes in stimulation frequency and culture medium viscosity effected proportional changes in the magnitude of the fluid shear stress (peak fluid shear stresses varied in the range 0.09-3.5 Pa), with minor effects on temporal and spatial distribution. Good agreement was obtained between predicted and measured radial flow patterns. These results suggest a reinterpretation of previous data obtained using this device to include the potential for a strong role of fluid shear stress in mechanosensitivity.

Edge-Induced Shear Banding in Entangled Polymeric Fluids

NASA Astrophysics Data System (ADS)

Hemingway, Ewan J.; Fielding, Suzanne M.

2018-03-01

Despite decades of research, the question of whether solutions and melts of highly entangled polymers exhibit shear banding as their steady state response to a steadily imposed shear flow remains controversial. From a theoretical viewpoint, an important unanswered question is whether the underlying constitutive curve of shear stress σ as a function of shear rate γ ˙ (for states of homogeneous shear) is monotonic, or has a region of negative slope, d σ /d γ ˙ <0 , which would trigger banding. Attempts to settle the question experimentally via velocimetry of the flow field inside the fluid are often confounded by an instability of the free surface where the sample meets the outside air, known as "edge fracture." Here we show by numerical simulation that in fact even only very modest edge disturbances—which are the precursor of full edge fracture but might well, in themselves, go unnoticed experimentally—can cause strong secondary flows in the form of shear bands that invade deep into the fluid bulk. Crucially, this is true even when the underlying constitutive curve is monotonically increasing, precluding true bulk shear banding in the absence of edge effects.

On a criterion of incipient motion and entrainment into suspension of a particle from cuttings bed in shear flow of non-Newtonian fluid

NASA Astrophysics Data System (ADS)

Ignatenko, Yaroslav; Bocharov, Oleg; May, Roland

2017-10-01

Solids transport is a major issue in high angle wells. Bed-load forms by sediment while transport and accompanied by intermittent contact with stream-bed by rolling, sliding and bouncing. The study presents the results of a numerical simulation of a laminar steady-state flow around a particle at rest and in free motion in a shear flow of Herschel-Bulkley fluid. The simulation was performed using the OpenFOAM open-source CFD package. A criterion for particle incipient motion and entrainment into suspension from cuttings bed (Shields criteria) based on forces and torques balance is discussed. Deflection of the fluid parameters from the ones of Newtonian fluid leads to decreasing of the drag and lift forces and the hydrodynamic moment. Thus, the critical shear stress (Shields parameter) for the considered non-Newtonian fluid must be greater than the one for a Newtonian fluid.

Direct numerical simulation of particle alignment in viscoelastic fluids

NASA Astrophysics Data System (ADS)

Hulsen, Martien; Jaensson, Nick; Anderson, Patrick

2016-11-01

Rigid particles suspended in viscoelastic fluids under shear can align in string-like structures in flow direction. To unravel this phenomenon, we present 3D direct numerical simulations of the alignment of two and three rigid, non-Brownian particles in a shear flow of a viscoelastic fluid. The equations are solved on moving, boundary-fitted meshes, which are locally refined to accurately describe the polymer stresses around and in between the particles. A small minimal gap size between the particles is introduced. The Giesekus model is used and the effect of the Weissenberg number, shear thinning and solvent viscosity is investigated. Alignment of two and three particles is observed. Morphology plots have been created for various combinations of fluid parameters. Alignment is mainly governed by the value of the elasticity parameter S, defined as half of the ratio between the first normal stress difference and shear stress of the suspending fluid. Alignment appears to occur above a critical value of S, which decreases with increasing shear thinning. This result, together with simulations of a shear-thinning Carreau fluid, leads us to the conclusion that normal stress differences are essential for particle alignment to occur, but it is also strongly promoted by shear thinning.

Breaking symmetry in non-planar bifurcations: distribution of flow and wall shear stress.

PubMed

Lu, Yiling; Lu, Xiyun; Zhuang, Lixian; Wang, Wen

2002-01-01

Non-planarity in blood vessels is known to influence arterial flows and wall shear stress. To gain insight, computational fluid dynamics (CFD) has been used to investigate effects of curvature and out-of-plane geometry on the distribution of fluid flows and wall shear stresses in a hypothetical non-planar bifurcation. Three-dimensional Navier-Stokes equations for a steady state Newtonian fluid were solved numerically using a finite element method. Non-planarity in one of the two daughter vessels is found to deflect flow from the inner wall of the vessel to the outer wall and to cause changes in the distribution of wall shear stresses. Results from this study agree to experimental observations and CFD simulations in the literature, and support the view that non-planarity in blood vessels is a factor with important haemodynamic significance and may play a key role in vascular biology and pathophysiology.

Dynamic bulk and shear moduli due to grain-scale local fluid flow in fluid-saturated cracked poroelastic rocks: Theoretical model

NASA Astrophysics Data System (ADS)

Song, Yongjia; Hu, Hengshan; Rudnicki, John W.

2016-07-01

Grain-scale local fluid flow is an important loss mechanism for attenuating waves in cracked fluid-saturated poroelastic rocks. In this study, a dynamic elastic modulus model is developed to quantify local flow effect on wave attenuation and velocity dispersion in porous isotropic rocks. The Eshelby transform technique, inclusion-based effective medium model (the Mori-Tanaka scheme), fluid dynamics and mass conservation principle are combined to analyze pore-fluid pressure relaxation and its influences on overall elastic properties. The derivation gives fully analytic, frequency-dependent effective bulk and shear moduli of a fluid-saturated porous rock. It is shown that the derived bulk and shear moduli rigorously satisfy the Biot-Gassmann relationship of poroelasticity in the low-frequency limit, while they are consistent with isolated-pore effective medium theory in the high-frequency limit. In particular, a simplified model is proposed to quantify the squirt-flow dispersion for frequencies lower than stiff-pore relaxation frequency. The main advantage of the proposed model over previous models is its ability to predict the dispersion due to squirt flow between pores and cracks with distributed aspect ratio instead of flow in a simply conceptual double-porosity structure. Independent input parameters include pore aspect ratio distribution, fluid bulk modulus and viscosity, and bulk and shear moduli of the solid grain. Physical assumptions made in this model include (1) pores are inter-connected and (2) crack thickness is smaller than the viscous skin depth. This study is restricted to linear elastic, well-consolidated granular rocks.

Real-Time Maps of Fluid Flow Fields in Porous Biomaterials

PubMed Central

Mack, Julia J.; Youssef, Khalid; Noel, Onika D.V.; Lake, Michael P.; Wu, Ashley; Iruela-Arispe, M. Luisa; Bouchard, Louis-S.

2013-01-01

Mechanical forces such as fluid shear have been shown to enhance cell growth and differentiation, but knowledge of their mechanistic effect on cells is limited because the local flow patterns and associated metrics are not precisely known. Here we present real-time, noninvasive measures of local hydrodynamics in 3D biomaterials based on nuclear magnetic resonance. Microflow maps were further used to derive pressure, shear and fluid permeability fields. Finally, remodeling of collagen gels in response to precise fluid flow parameters was correlated with structural changes. It is anticipated that accurate flow maps within 3D matrices will be a critical step towards understanding cell behavior in response to controlled flow dynamics. PMID:23245922

A numerical approach for assessing effects of shear on equivalent permeability and nonlinear flow characteristics of 2-D fracture networks

NASA Astrophysics Data System (ADS)

Liu, Richeng; Li, Bo; Jiang, Yujing; Yu, Liyuan

2018-01-01

Hydro-mechanical properties of rock fractures are core issues for many geoscience and geo-engineering practices. Previous experimental and numerical studies have revealed that shear processes could greatly enhance the permeability of single rock fractures, yet the shear effects on hydraulic properties of fractured rock masses have received little attention. In most previous fracture network models, single fractures are typically presumed to be formed by parallel plates and flow is presumed to obey the cubic law. However, related studies have suggested that the parallel plate model cannot realistically represent the surface characters of natural rock fractures, and the relationship between flow rate and pressure drop will no longer be linear at sufficiently large Reynolds numbers. In the present study, a numerical approach was established to assess the effects of shear on the hydraulic properties of 2-D discrete fracture networks (DFNs) in both linear and nonlinear regimes. DFNs considering fracture surface roughness and variation of aperture in space were generated using an originally developed code DFNGEN. Numerical simulations by solving Navier-Stokes equations were performed to simulate the fluid flow through these DFNs. A fracture that cuts through each model was sheared and by varying the shear and normal displacements, effects of shear on equivalent permeability and nonlinear flow characteristics of DFNs were estimated. The results show that the critical condition of quantifying the transition from a linear flow regime to a nonlinear flow regime is: 10-4 〈 J < 10-3, where J is the hydraulic gradient. When the fluid flow is in a linear regime (i.e., J < 10-4), the relative deviation of equivalent permeability induced by shear, δ2, is linearly correlated with J with small variations, while for fluid flow in the nonlinear regime (J 〉 10-3), δ2 is nonlinearly correlated with J. A shear process would reduce the equivalent permeability significantly in the orientation perpendicular to the sheared fracture as much as 53.86% when J = 1, shear displacement Ds = 7 mm, and normal displacement Dn = 1 mm. By fitting the calculated results, the mathematical expression for δ2 is established to help choose proper governing equations when solving fluid flow problems in fracture networks.

Stagnation point flow of wormlike micellar solutions in a microfluidic cross-slot device: effects of surfactant concentration and ionic environment.

PubMed

Haward, Simon J; McKinley, Gareth H

2012-03-01

We employ the techniques of microparticle image velocimetry and full-field birefringence microscopy combined with mechanical measurements of the pressure drop to perform a detailed characterization of the extensional rheology and elastic flow instabilities observed for a range of wormlike micellar solutions flowing through a microfluidic cross-slot device. As the flow rate through the device is increased, the flow first bifurcates from a steady symmetric to a steady asymmetric configuration characterized by a birefringent strand of highly aligned micellar chains oriented along the shear-free centerline of the flow field. At higher flow rates the flow becomes three dimensional and time dependent and is characterized by aperiodic spatiotemporal fluctuations of the birefringent strand. The extensional properties and critical conditions for the onset of flow instabilities in the fluids are highly dependent on the fluid formulation (surfactant concentration and ionic strength) and the resulting changes in the linear viscoelasticity and nonlinear shear rheology of the fluids. By combining the measurements of critical conditions for the flow transitions with the viscometric material properties and the degree of shear-thinning characterizing each test fluid, it is possible to construct a stability diagram for viscoelastic flow of complex fluids in the cross-slot geometry.

Analytical solution of two-fluid electro-osmotic flows of viscoelastic fluids.

PubMed

Afonso, A M; Alves, M A; Pinho, F T

2013-04-01

This paper presents an analytical model that describes a two-fluid electro-osmotic flow of stratified fluids with Newtonian or viscoelastic rheological behavior. This is the principle of operation of an electro-osmotic two-fluid pump as proposed by Brask et al. [Tech. Proc. Nanotech., 1, 190-193, 2003], in which an electrically non-conducting fluid is transported by the interfacial dragging viscous force of a conducting fluid that is driven by electro-osmosis. The electric potential in the conducting fluid and the analytical steady flow solution of the two-fluid electro-osmotic stratified flow in a planar microchannel are presented by assuming a planar interface between the two immiscible fluids with Newtonian or viscoelastic rheological behavior. The effects of fluid rheology, shear viscosity ratio, holdup and interfacial zeta potential are analyzed to show the viability of this technique, where an enhancement of the flow rate is observed as the shear-thinning effects are increased. Copyright © 2012 Elsevier Inc. All rights reserved.

F-actin and microtubule suspensions as indeterminate fluids.

PubMed

Buxbaum, R E; Dennerll, T; Weiss, S; Heidemann, S R

1987-03-20

The viscosity of F-actin and microtubule suspensions has been measured as a function of shear rate with a Weissenberg rheogoniometer. At shear rates of less than 1.0 per second the viscosity of suspensions of these two structural proteins is inversely proportional to shear rate. These results are consistent with previous in vivo measurements of the viscosity of cytoplasm. This power law implies that shear stress is independent of shear rate; that is, shear stress is a constant at all shear rates less than 1.0 per second. Thus the flow profile of these fluids is indeterminate, or nearly so. This flow property may explain several aspects of intracellular motility in living cells. Possible explanations for this flow property are based on a recent model for semidilute suspensions of rigid rods or a classical friction model for liquid crystals.

Laser induced fluorescence measurements of ion velocity and temperature of drift turbulence driven sheared plasma flow in a linear helicon plasma device

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chakraborty Thakur, S.; Fedorczak, N.; Manz, P.

2012-08-15

Using laser induced fluorescence (LIF), radial profiles of azimuthal ion fluid velocity and ion temperature are measured in the controlled shear de-correlation experiment (CSDX) linear helicon plasma device. Ion velocities and temperatures are derived from the measured Doppler broadened velocity distribution functions of argon ions. The LIF system employs a portable, high power (>300 mW), narrowband ({approx}1 MHz) tunable diode laser-based system operating at 668.614 nm. Previous studies in CSDX have shown the existence of a radially sheared azimuthal flow as measured with time delay estimation methods and Mach probes. Here, we report the first LIF measurements of sheared plasmamore » fluid flow in CSDX. Above a critical magnetic field, the ion fluid flow profile evolves from radially uniform to peaked on axis with a distinct reversed flow region at the boundary, indicating the development of a sheared azimuthal flow. Simultaneously, the ion temperature also evolves from a radially uniform profile to a profile with a gradient. Measurements in turbulent and coherent drift wave mode dominated plasmas are compared.« less

Process viscometry in flows of non-Newtonian fluids using an anchor agitator

NASA Astrophysics Data System (ADS)

Jo, Hae Jin; Jang, Hye Kyeong; Kim, Young Ju; Hwang, Wook Ryol

2017-11-01

In this work, we present a viscosity measurement technique for inelastic non-Newtonian fluids directly in flows of anchor agitators that are commonly used in highly viscous fluid mixing particularly with yield stress. A two-blade anchor impeller is chosen as a model flow system and Carbopol 940 solutions and Xanthan gum solutions with various concentrations are investigated as test materials. Following the Metzner-Otto correlation, the effective shear rate constant and the energy dissipation rate constant have been estimated experimentally by establishing (i) the relationship between the power number and the Reynolds number using a reference Newtonian fluid and (ii) the proportionality between the effective shear rate and the impeller speed with a reference non-Newtonian fluid. The effective viscosity that reproduces the same amount of the energy dissipation rate, corresponding to that of Newtonian fluid, has been obtained by measuring torques for various impeller speeds and the accuracy in the viscosity prediction as a function of the shear rate has been compared with the rheological measurement. We report that the process viscometry with the anchor impeller yields viscosity estimation within the relative error of 20% with highly shear-thinning fluids.

Time-frequency analyses of fluid-solid interaction under sinusoidal translational shear deformation of the viscoelastic rat cerebrum

NASA Astrophysics Data System (ADS)

Leahy, Lauren N.; Haslach, Henry W.

2018-02-01

During normal extracellular fluid (ECF) flow in the brain glymphatic system or during pathological flow induced by trauma resulting from impacts and blast waves, ECF-solid matter interactions result from sinusoidal shear waves in the brain and cranial arterial tissue, both heterogeneous biological tissues with high fluid content. The flow in the glymphatic system is known to be forced by pulsations of the cranial arteries at about 1 Hz. The experimental shear stress response to sinusoidal translational shear deformation at 1 Hz and 25% strain amplitude and either 0% or 33% compression is compared for rat cerebrum and bovine aortic tissue. Time-frequency analyses aim to correlate the shear stress signal frequency components over time with the behavior of brain tissue constituents to identify the physical source of the shear nonlinear viscoelastic response. Discrete fast Fourier transformation analysis and the novel application to the shear stress signal of harmonic wavelet decomposition both show significant 1 Hz and 3 Hz components. The 3 Hz component in brain tissue, whose magnitude is much larger than in aortic tissue, may result from interstitial fluid induced drag forces. The harmonic wavelet decomposition locates 3 Hz harmonics whose magnitudes decrease on subsequent cycles perhaps because of bond breaking that results in easier fluid movement. Both tissues exhibit transient shear stress softening similar to the Mullins effect in rubber. The form of a new mathematical model for the drag force produced by ECF-solid matter interactions captures the third harmonic seen experimentally.

Flow of a Casson fluid through a locally-constricted porous channel: a numerical study

NASA Astrophysics Data System (ADS)

Amlimohamadi, Haleh; Akram, Maryammosadat; Sadeghy, Kayvan

2016-05-01

Flow of a Casson fluid through a two-dimensional porous channel containing a local constriction is numerically investigated assuming that the resistance offered by the porous medium obeys the Darcy's law. Treating the constriction as another porous medium which obeys the Darcy-Forcheimer model, the equations governing fluid flow in the main channel and the constriction itself are numerically solved using the finite-volume method (FVM) based on the pseudo-transient SIMPLE algorithm. It is shown that an increase in the porosity of the channel decreases the shear stress exerted on the constriction. On the other hand, an increase in the fluid's yield stress is predicted to increase the maximum shear stress experienced by the constriction near its crest. The porosity of the constriction itself is predicted to have a negligible effect on the plaque's shear stress. But, the momentum of the weak flow passing through the constriction is argued to lower the bulk fluid from separating downstream of the constriction.

Effect of pulse pressure on borehole stability during shear swirling flow vibration cementing.

PubMed

Cui, Zhihua; Ai, Chi; Lv, Lei; Yin, Fangxian

2017-01-01

The shear swirling flow vibration cementing (SSFVC) technique rotates the downhole eccentric cascade by circulating cementing fluid. It makes the casing eccentrically revolve at high speed around the borehole axis. It produces strong agitation action to the annulus fluid, makes it in the state of shear turbulent flow, and results in the formation of pulse pressure which affects the surrounding rock stress. This study was focused on 1) the calculation of the pulse pressure in an annular turbulent flow field based on the finite volume method, and 2) the analysis of the effect of pulse pressure on borehole stability. On the upside, the pulse pressure is conducive to enhancing the liquidity of the annulus fluid, reducing the fluid gel strength, and preventing the formation of fluid from channeling. But greater pulse pressure may cause lost circulation and even formation fracturing. Therefore, in order to ensure smooth cementing during SSFVC, the effect of pulse pressure should be considered when cementing design.

Fluid Mechanics, Arterial Disease, and Gene Expression.

PubMed

Tarbell, John M; Shi, Zhong-Dong; Dunn, Jessilyn; Jo, Hanjoong

2014-01-01

This review places modern research developments in vascular mechanobiology in the context of hemodynamic phenomena in the cardiovascular system and the discrete localization of vascular disease. The modern origins of this field are traced, beginning in the 1960s when associations between flow characteristics, particularly blood flow-induced wall shear stress, and the localization of atherosclerotic plaques were uncovered, and continuing to fluid shear stress effects on the vascular lining endothelial) cells (ECs), including their effects on EC morphology, biochemical production, and gene expression. The earliest single-gene studies and genome-wide analyses are considered. The final section moves from the ECs lining the vessel wall to the smooth muscle cells and fibroblasts within the wall that are fluid me chanically activated by interstitial flow that imposes shear stresses on their surfaces comparable with those of flowing blood on EC surfaces. Interstitial flow stimulates biochemical production and gene expression, much like blood flow on ECs.

Depth resolved granular transport driven by shearing fluid flow

NASA Astrophysics Data System (ADS)

Allen, Benjamin; Kudrolli, Arshad

2017-02-01

We investigate granular transport by a fluid flow under steady-state driving conditions, from the bed-load regime to the suspension regime, with an experimental system based on a conical rheometer. The mean granular volume fraction ϕg, the mean granular velocity ug, and the fluid velocity uf are obtained as a function of depth inside the bed using refractive index matching and particle-tracking techniques. A torque sensor is utilized to measure the applied shear stress to complement estimates obtained from measured strain rates high above the bed where ϕg≈0 . The flow is found to be transitional at the onset of transport and the shear stress required to transport grains rises sharply as grains are increasingly entrained by the fluid flow. A significant slip velocity between the fluid and the granular phases is observed at the bed surface before the onset of transport as well as in the bed-load transport regime. We show that ug decays exponentially deep into the bed for ϕg>0.45 with a decay constant which is described by a nonlocal rheology model of granular flow that neglects fluid stress. Further, we show that uf and ug can be described using the applied shear stress and the Krieger-Dougherty model for the effective viscosity in the suspension regime, where 0 <ϕg<0.45 and where ug≈uf .

On multiple solutions of non-Newtonian Carreau fluid flow over an inclined shrinking sheet

NASA Astrophysics Data System (ADS)

Khan, Masood; Sardar, Humara; Gulzar, M. Mudassar; Alshomrani, Ali Saleh

2018-03-01

This paper presents the multiple solutions of a non-Newtonian Carreau fluid flow over a nonlinear inclined shrinking surface in presence of infinite shear rate viscosity. The governing boundary layer equations are derived for the Carreau fluid with infinite shear rate viscosity. The suitable transformations are employed to alter the leading partial differential equations to a set of ordinary differential equations. The consequential non-linear ODEs are solved numerically by an active numerical approach namely Runge-Kutta Fehlberg fourth-fifth order method accompanied by shooting technique. Multiple solutions are presented graphically and results are shown for various physical parameters. It is important to state that the velocity and momentum boundary layer thickness reduce with increasing viscosity ratio parameter in shear thickening fluid while opposite trend is observed for shear thinning fluid. Another important observation is that the wall shear stress is significantly decreased by the viscosity ratio parameter β∗ for the first solution and opposite trend is observed for the second solution.

Extensional flow of blood analog solutions in microfluidic devices

PubMed Central

Sousa, P. C.; Pinho, F. T.; Oliveira, M. S. N.; Alves, M. A.

2011-01-01

In this study, we show the importance of extensional rheology, in addition to the shear rheology, in the choice of blood analog solutions intended to be used in vitro for mimicking the microcirculatory system. For this purpose, we compare the flow of a Newtonian fluid and two well-established viscoelastic blood analog polymer solutions through microfluidic channels containing both hyperbolic and abrupt contractions∕expansions. The hyperbolic shape was selected in order to impose a nearly constant strain rate at the centerline of the microchannels and achieve a quasihomogeneous and strong extensional flow often found in features of the human microcirculatory system such as stenoses. The two blood analog fluids used are aqueous solutions of a polyacrylamide (125 ppm w∕w) and of a xanthan gum (500 ppm w∕w), which were characterized rheologically in steady-shear flow using a rotational rheometer and in extension using a capillary breakup extensional rheometer (CaBER). Both blood analogs exhibit a shear-thinning behavior similar to that of whole human blood, but their relaxation times, obtained from CaBER experiments, are substantially different (by one order of magnitude). Visualizations of the flow patterns using streak photography, measurements of the velocity field using microparticle image velocimetry, and pressure-drop measurements were carried out experimentally for a wide range of flow rates. The experimental results were also compared with the numerical simulations of the flow of a Newtonian fluid and a generalized Newtonian fluid with shear-thinning behavior. Our results show that the flow patterns of the two blood analog solutions are considerably different, despite their similar shear rheology. Furthermore, we demonstrate that the elastic properties of the fluid have a major impact on the flow characteristics, with the polyacrylamide solution exhibiting a much stronger elastic character. As such, these properties must be taken into account in the choice or development of analog fluids that are adequate to replicate blood behavior at the microscale. PMID:21483662

Simulation study on the trembling shear behavior of eletrorheological fluid.

PubMed

Yang, F; Gong, X L; Xuan, S H; Jiang, W Q; Jiang, C X; Zhang, Z

2011-07-01

The trembling shear behavior of electrorheological (ER) fluids has been investigated by using a computer simulation method, and a shear-slide boundary model is proposed to understand this phenomenon. A thiourea-doped Ba-Ti-O ER fluid which shows a trembling shear behavior was first prepared and then systematically studied by both theoretical and experimental methods. The shear curves of ER fluids in the dynamic state were simulated with shear rates from 0.1 to 1000 s(-1) under different electric fields. The simulation results of the flow curves match the experimental results very well. The trembling shear curves are divided into four regions and each region can be explained by the proposed model.

Evaluation of dispersive mixing, extension rate and bubble size distribution using numerical simulation of a non-Newtonian fluid in a twin-screw mixer

NASA Astrophysics Data System (ADS)

Rathod, Maureen L.

Initially 3D FEM simulation of a simplified mixer was used to examine the effect of mixer configuration and operating conditions on dispersive mixing of a non-Newtonian fluid. Horizontal and vertical velocity magnitudes increased with increasing mixer speed, while maximum axial velocity and shear rate were greater with staggered paddles. In contrast, parallel paddles produced an area of efficient dispersive mixing between the center of the paddle and the barrel wall. This study was expanded to encompass the complete nine-paddle mixing section using power-law and Bird-Carreau fluid models. In the center of the mixer, simple shear flow was seen, corresponding with high [special character omitted]. Efficient dispersive mixing appeared near the barrel wall at all flow rates and near the barrel center with parallel paddles. Areas of backflow, improving fluid retention time, occurred with staggered paddles. The Bird-Carreau fluid showed greater influence of paddle motion under the same operating conditions due to the inelastic nature of the fluid. Shear-thinning behavior also resulted in greater maximum shear rate as shearing became easier with decreasing fluid viscosity. Shear rate distributions are frequently calculated, but extension rate calculations have not been made in a complex geometry since Debbaut and Crochet (1988) defined extension rate as the ratio of the third to the second invariant of the strain rate tensor. Extension rate was assumed to be negligible in most studies, but here extension rate is shown to be significant. It is possible to calculate maximum stable bubble diameter from capillary number if shear and extension rates in a flow field are known. Extension rate distributions were calculated for Newtonian and non-Newtonian fluids. High extension and shear rates were found in the intermeshing region. Extension is the major influence on critical capillary number and maximum stable bubble diameter, but when extension rate values are low shear rate has a larger impact. Examination of maximum stable bubble diameter through the mixer predicted areas of higher bubble dispersion based on flow type. This research has advanced simulation of non-Newtonian fluid and shown that direct calculation of extension rate is possible, demonstrating the effect of extension rate on bubble break-up.

Edge-Induced Shear Banding in Entangled Polymeric Fluids.

PubMed

Hemingway, Ewan J; Fielding, Suzanne M

2018-03-30

Despite decades of research, the question of whether solutions and melts of highly entangled polymers exhibit shear banding as their steady state response to a steadily imposed shear flow remains controversial. From a theoretical viewpoint, an important unanswered question is whether the underlying constitutive curve of shear stress σ as a function of shear rate γ[over ˙] (for states of homogeneous shear) is monotonic, or has a region of negative slope, dσ/dγ[over ˙]<0, which would trigger banding. Attempts to settle the question experimentally via velocimetry of the flow field inside the fluid are often confounded by an instability of the free surface where the sample meets the outside air, known as "edge fracture." Here we show by numerical simulation that in fact even only very modest edge disturbances-which are the precursor of full edge fracture but might well, in themselves, go unnoticed experimentally-can cause strong secondary flows in the form of shear bands that invade deep into the fluid bulk. Crucially, this is true even when the underlying constitutive curve is monotonically increasing, precluding true bulk shear banding in the absence of edge effects.

Alkaline phosphatase in osteoblasts is down-regulated by pulsatile fluid flow

NASA Technical Reports Server (NTRS)

Hillsley, M. V.; Frangos, J. A.

1997-01-01

It is our hypothesis that interstitial fluid flow plays a role in the bone remodeling response to mechanical loading. The fluid flow-induced expression of three proteins (collagen, osteopontin, and alkaline phosphatase) involved in bone remodeling was investigated. Rat calvarial osteoblasts subjected to pulsatile fluid flow at an average shear stress of 5 dyne/cm2 showed decreased alkaline phosphatase (AP) mRNA expression after only 1 hour of flow. After 3 hours of flow, AP mRNA levels had decreased to 30% of stationary control levels and remained at this level for an additional 5 hours of flow. Steady flow (4 dyne/cm2 fluid shear stress), in contrast, resulted in a delayed and less dramatic decrease in AP mRNA expression to 63% of control levels after 8 hours of flow. The reduced AP mRNA expression under pulsatile flow conditions was followed by reduced AP enzyme activity after 24 hours. No changes in collagen or osteopontin mRNA expression were detected over 8 hours of pulsatile flow. This is the first time fluid flow has been shown to affect gene expression in osteoblasts.

Viscous properties of isotropic fluids composed of linear molecules: departure from the classical Navier-Stokes theory in nano-confined geometries.

PubMed

Hansen, J S; Daivis, Peter J; Todd, B D

2009-10-01

In this paper we present equilibrium molecular-dynamics results for the shear, rotational, and spin viscosities for fluids composed of linear molecules. The density dependence of the shear viscosity follows a stretched exponential function, whereas the rotational viscosity and the spin viscosities show approximately power-law dependencies. The frequency-dependent shear and spin viscosities are also studied. It is found that viscoelastic behavior is first manifested in the shear viscosity and that the real part of the spin viscosities features a maximum for nonzero frequency. The calculated transport coefficients are used together with the extended Navier-Stokes equations to investigate the effect of the coupling between the intrinsic angular momentum and linear momentum for highly confined fluids. Both steady and oscillatory flows are studied. It is shown, for example, that the fluid flow rate for Poiseuille flow is reduced by up to 10% in a 2 nm channel for a buta-triene fluid at density 236 kg m(-3) and temperature 306 K. The coupling effect may, therefore, become very important for nanofluidic applications.

Rheological characterization of modified foodstuffs with food grade thickening agents

NASA Astrophysics Data System (ADS)

Reyes-Ocampo, I.; Aguayo-Vallejo, JP; Ascanio, G.; Córdova-Aguilar, MS

2017-01-01

This work describes a rheological characterization in terms of shear and extensional properties of whole milk, modified with food grade thickening agents (xanthan and carboxymethyl cellulose) with the purpose of being utilized in dysphagia treatment. Shear viscosity of the thickened fluids (2% wt. of xanthan and CMC) were measured in a stress-controlled rheometer and for extensional viscosity, a custom-built orifice flowmeter was used, with elongation rates from 20 to 3000 s-1. Such elongation-rate values represent the entire swallowing process, including the pharyngeal and esophageal phases. The steady-state shear and extensional flow curves were compared with the flow curve of a pudding consistency BaSO4 suspension (α=05), typically used as a reference fluid for the specialized commercial dysphagia products. The modified fluids presented non-Newtonian behavior in both, shear and extensional flows, and the comparison with the reference fluid show that the thickened milk prepared here, can be safely used for consumption by patients with severe dysphagia.

Steady and transient fluid shear stress stimulate NO release in osteoblasts through distinct biochemical pathways

NASA Technical Reports Server (NTRS)

McAllister, T. N.; Frangos, J. A.

1999-01-01

Fluid flow has been shown to be a potent stimulus in osteoblasts and osteocytes and may therefore play an important role in load-induced bone remodeling. The objective of this study was to investigate the characteristics of flow-activated pathways. Previously we reported that fluid flow stimulates rapid and continuous release of nitric oxide (NO) in primary rat calvarial osteoblasts. Here we demonstrate that flow-induced NO release is mediated by shear stress and that this response is distinctly biphasic. Transients in shear stress associated with the onset of flow stimulated a burst in NO production (8.2 nmol/mg of protein/h), while steady flow stimulated sustained NO production (2.2 nmol/mg of protein/h). Both G-protein inhibition and calcium chelation abolished the burst phase but had no effect on sustained production. Activation of G-proteins stimulated dose-dependent NO release in static cultures of both calvarial osteoblasts and UMR-106 osteoblast-like cells. Pertussis toxin had no effect on NO release. Calcium ionophore stimulated low levels of NO production within 15 minutes but had no effect on sustained production. Taken together, these data suggest that fluid shear stress stimulates NO release by two distinct pathways: a G-protein and calcium-dependent phase sensitive to flow transients, and a G-protein and calcium-independent pathway stimulated by sustained flow.

Observation of turbulent-driven shear flow in a cylindrical laboratory plasma device.

PubMed

Holland, C; Yu, J H; James, A; Nishijima, D; Shimada, M; Taheri, N; Tynan, G R

2006-05-19

An azimuthally symmetric radially sheared plasma fluid flow is observed to spontaneously form in a cylindrical magnetized helicon plasma device with no external sources of momentum input. A turbulent momentum conservation analysis shows that this shear flow is sustained by the Reynolds stress generated by collisional drift turbulence in the device. The results provide direct experimental support for the basic theoretical picture of drift-wave-shear-flow interactions.

Shear thinning and shear thickening of a confined suspension of vesicles

NASA Astrophysics Data System (ADS)

Nait Ouhra, A.; Farutin, A.; Aouane, O.; Ez-Zahraouy, H.; Benyoussef, A.; Misbah, C.

2018-01-01

Widely regarded as an interesting model system for studying flow properties of blood, vesicles are closed membranes of phospholipids that mimic the cytoplasmic membranes of red blood cells. In this study we analyze the rheology of a suspension of vesicles in a confined geometry: the suspension, bound by two planar rigid walls on each side, is subject to a shear flow. Flow properties are then analyzed as a function of shear rate γ ˙, the concentration of the suspension ϕ , and the viscosity contrast λ =ηin/ηout , where ηin and ηout are the fluid viscosities of the inner and outer fluids, respectively. We find that the apparent (or effective viscosity) of the suspension exhibits both shear thinning (decreasing viscosity with shear rate) or shear thickening (increasing viscosity with shear rate) in the same concentration range. The shear thinning or thickening behaviors appear as subtle phenomena, dependant on viscosity contrast λ . We provide physical arguments on the origins of these behaviors.

Vesicle electrohydrodynamics.

PubMed

Schwalbe, Jonathan T; Vlahovska, Petia M; Miksis, Michael J

2011-04-01

A small amplitude perturbation analysis is developed to describe the effect of a uniform electric field on the dynamics of a lipid bilayer vesicle in a simple shear flow. All media are treated as leaky dielectrics and fluid motion is described by the Stokes equations. The instantaneous vesicle shape is obtained by balancing electric, hydrodynamic, bending, and tension stresses exerted on the membrane. We find that in the absence of ambient shear flow, it is possible that an applied stepwise uniform dc electric field could cause the vesicle shape to evolve from oblate to prolate over time if the encapsulated fluid is less conducting than the suspending fluid. For a vesicle in ambient shear flow, the electric field damps the tumbling motion, leading to a stable tank-treading state.

Diffractive Optic Fluid Shear Stress Sensor

NASA Technical Reports Server (NTRS)

Wilson, D.; Scalf, J.; Forouhar, S.; Muller, R.; Taugwalder, F.; Gharib, M.; Fourguette, D.; Modarress, D.

2000-01-01

Light scattering off particles flowing through a two-slit interference pattern can be used to measure the shear stress of the fluid. We have designed and fabricated a miniature diffractive optic sensor based on this principle.

Scale Effects in the Flow of a Shear-Thinning Fluid in Geological Fractures

NASA Astrophysics Data System (ADS)

Meheust, Y.; Roques, C.; Le Borgne, T.; Selker, J. S.

2017-12-01

Subsurface flow processes involving non-Newtonian fluids play a major role in many engineering applications, from in-situ remediation to enhanced oil recovery. The fluids of interest in such applications (f.e., polymers in remediation) often present shear-thinning properties, i.e., their viscosity decreases as a function of the local shear rate. We investigate how fracture wall roughness impacts the flow of a shear-thinning fluid. Numerical simulations of flow in 3D geological fractures are carried out by solving a modified Navier-Stokes equation incorporating the Carreau viscous-shear model. The numerical fractures consist of two isotropic self-affine surfaces which are correlated with each other above a characteristic scale (thecorrelation length of Méheust et al. PAGEOPH 2003). Perfect plastic closing is assumed when the surfaces are in contact. The statistical parameters describing a fracture are the standard deviation of the wall roughness, the mean aperture, the correlation length, and the fracture length, the Hurst exponent being fixed (equal to 0.8). The objective is to investigate how varying the correlation length impacts the flow behavior, for different degrees of closure, and how this behavior diverges from what is known for Newtonian fluids. The results from the 3D simulations are also compared to 2D simulations based on the lubrication theory, which we have developed as an extension of the Reynolds equation for Newtonian fluids. These 2D simulations run orders of magnitude faster, which allows considering a significant statistics of fractures of identical statistical parameters, and therefore draw general conclusions despite the large stochasticity of the media. We also discuss the implications of our results for solute transport by such flows. References:Méheust, Y., & Schmittbuhl, J. (2003). Scale effects related to flow in rough fractures. Pure and Applied Geophysics, 160(5-6), 1023-1050.

Numerical Simulation in Steady Flow of Newtonian and Shear Thickening Fluids in Pipes With Circular Cross-Section

NASA Astrophysics Data System (ADS)

Galindo-Rosales, F. J.; Rubio-Hernández, F. J.

2008-07-01

Process engineering deals with the processing of large quantities of materials and they must be transported from one unit operation to another within the processing environment. This is commonly made through pipelines, where occurs a dissipation of energy due essentially to frictional losses against the inside wall of the pipe and changes in the internal energy. Then it is needed an energy source to keep the fluid moving, commonly a pump. Due to differences in the internal structure, dissipations of energy must be different from Newtonian fluids to shear thickening fluids. Moreover, because of the inherent structure that is exhibited by shear thickening fluids, laminar motion of these fluids is encountered far more commonly than with Newtonian fluids. Rheological experiments confirm that suspensions of Aerosil®R816 in Polypropylene glycol (PPG) of low molecular weights (400 and 2000 g/mol) exhibit reversible shear thickening behaviour. Cross model fits properly their viscosity curve in the region of shear thickening behaviour. Thus the constitutive equations obtained experimentally have been incorporated into the momentum conservation equation in order to study the reference case of the steady laminar flow in a pipe of circular cross-section, providing us with relevant information including the fully-developed velocity profiles, the friction factor and the entrance length, depending on the rheological properties of each suspension. Our results could be applied to the optimal design and layout of flow networks, which may represent a significant fraction of the total plant cost.

Nanoscale simple-fluid behavior under steady shear.

PubMed

Yong, Xin; Zhang, Lucy T

2012-05-01

In this study, we use two nonequilibrium molecular dynamics algorithms, boundary-driven shear and homogeneous shear, to explore the rheology and flow properties of a simple fluid undergoing steady simple shear. The two distinct algorithms are designed to elucidate the influences of nanoscale confinement. The results of rheological material functions, i.e., viscosity and normal pressure differences, show consistent Newtonian behaviors at low shear rates from both systems. The comparison validates that confinements of the order of 10 nm are not strong enough to deviate the simple fluid behaviors from the continuum hydrodynamics. The non-Newtonian phenomena of the simple fluid are further investigated by the homogeneous shear simulations with much higher shear rates. We observe the "string phase" at high shear rates by applying both profile-biased and profile-unbiased thermostats. Contrary to other findings where the string phase is found to be an artifact of the thermostats, we perform a thorough analysis of the fluid microstructures formed due to shear, which shows that it is possible to have a string phase and second shear thinning for dense simple fluids.

The Magnetohydrodynamic Kelvin-Helmholtz Instability. III. The Role of Sheared Magnetic Field in Planar Flows

NASA Astrophysics Data System (ADS)

Jeong, Hyunju; Ryu, Dongsu; Jones, T. W.; Frank, Adam

2000-01-01

We have carried out simulations of the nonlinear evolution of the magnetohydrodynamic (MHD) Kelvin-Helmholtz (KH) instability for compressible fluids in 2.5 dimensions, extending our previous work by Frank et al. and Jones et al. In the present work we have simulated flows in the x-y plane in which a ``sheared'' magnetic field of uniform strength smoothly rotates across a thin velocity shear layer from the z-direction to the x-direction, aligned with the flow field. The sonic Mach number of the velocity transition is unity. Such flows containing a uniform field in the x-direction are linearly stable if the magnetic field strength is great enough that the Alfvénic Mach number MA=U0/cA<2. That limit does not apply directly to sheared magnetic fields, however, since the z-field component has almost no influence on the linear stability. Thus, if the magnetic shear layer is contained within the velocity shear layer, the KH instability may still grow, even when the field strength is quite large. So, here we consider a wide range of sheared field strengths covering Alfvénic Mach numbers, MA=142.9 to 2. We focus on dynamical evolution of fluid features, kinetic energy dissipation, and mixing of the fluid between the two layers, considering their dependence on magnetic field strength for this geometry. There are a number of differences from our earlier simulations with uniform magnetic fields in the x-y plane. For the latter, simpler case we found a clear sequence of behaviors with increasing field strength ranging from nearly hydrodynamic flows in which the instability evolves to an almost steady cat's eye vortex with enhanced dissipation, to flows in which the magnetic field disrupts the cat's eye once it forms, to, finally, flows that evolve very little before field-line stretching stabilizes the velocity shear layer. The introduction of magnetic shear can allow a cat's eye-like vortex to form, even when the field is stronger than the nominal linear instability limit given above. For strong fields that vortex is asymmetric with respect to the preliminary shear layer, however, so the subsequent dissipation is enhanced over the uniform field cases of comparable field strength. In fact, so long as the magnetic field achieves some level of dynamical importance during an eddy turnover time, the asymmetries introduced through the magnetic shear will increase flow complexity and, with that, dissipation and mixing. The degree of the fluid mixing between the two layers is strongly influenced by the magnetic field strength. Mixing of the fluid is most effective when the vortex is disrupted by magnetic tension during transient reconnection, through local chaotic behavior that follows.

Nonlinear oscillatory rheology and structure of wormlike micellar solutions and colloidal suspensions

NASA Astrophysics Data System (ADS)

Gurnon, Amanda Kate

The complex, nonlinear flow behavior of soft materials transcends industrial applications, smart material design and non-equilibrium thermodynamics. A long-standing, fundamental challenge in soft-matter science is establishing a quantitative connection between the deformation field, local microstructure and macroscopic dynamic flow properties i.e., the rheology. Soft materials are widely used in consumer products and industrial processes including energy recovery, surfactants for personal healthcare (e.g. soap and shampoo), coatings, plastics, drug delivery, medical devices and therapeutics. Oftentimes, these materials are processed by, used during, or exposed to non-equilibrium conditions for which the transient response of the complex fluid is critical. As such, designing new dynamic experiments is imperative to testing these materials and further developing micromechanical models to predict their transient response. Two of the most common classes of these soft materials stand as the focus of the present research; they are: solutions of polymer-like micelles (PLM or also known as wormlike micelles, WLM) and concentrated colloidal suspensions. In addition to their varied applications these two different classes of soft materials are also governed by different physics. In contrast, to the shear thinning behavior of the WLMs at high shear rates, the near hard-sphere colloidal suspensions are known to display increases, sometimes quite substantial, in viscosity (known as shear thickening). The stress response of these complex fluids derive from the shear-induced microstructure, thus measurements of the microstructure under flow are critical for understanding the mechanisms underlying the complex, nonlinear rheology of these complex fluids. A popular micromechanical model is reframed from its original derivation for predicting steady shear rheology of polymers and WLMs to be applicable to weakly nonlinear oscillatory shear flow. The validity, utility and limits of this constitutive model are tested by comparison with experiments on model WLM solutions. Further comparisons to the nonlinear oscillatory shear responses measured from colloidal suspensions establishes this analysis as a promising, quantitative method for understanding the underlying mechanisms responsible for the nonlinear dynamic response of complex fluids. A new experimental technique is developed to measure the microstructure of complex fluids during steady and transient shear flow using small-angle neutron scattering (SANS). The Flow-SANS experimental method is now available to the broader user communities at the NIST Center for Neutron Research, Gaithersburg, MD and the Institut Laue-Langevin, Grenoble, France. Using this new method, a model shear banding WLM solution is interrogated under steady and oscillatory shear. For the first time, the flow-SANS methods identify new metastable states for shear banding WLM solutions, thus establishing the method as capable of probing new states not accessible using traditional steady or linear oscillatory shear methods. The flow-induced three-dimensional microstructure of a colloidal suspension under steady and dynamic oscillatory shear is also measured using these rheo- and flow-SANS methods. A new structure state is identified in the shear thickening regime that proves critical for defining the "hydrocluster" microstructure state of the suspension that is responsible for shear thickening. For both the suspensions and the WLM solutions, stress-SANS rules with the measured microstructures define the individual stress components arising separately from conservative and hydrodynamic forces and these are compared with the macroscopic rheology. Analysis of these results defines the crucial length- and time-scales of the transient microstructure response. The novel dynamic microstructural measurements presented in this dissertation provide new insights into the complexities of shear thickening and shear banding flow phenomena, which are effects observed more broadly across many different types of soft materials. Consequently, the microstructure-rheology property relationships developed for these two classes of complex fluids will aid in the testing and advancement of micromechanical constitutive model development, smart material design, industrial processing and fundamental non-equilibrium thermodynamic research of a broad range of soft materials.

Rheology of dilute cohesive granular gases

NASA Astrophysics Data System (ADS)

Takada, Satoshi; Hayakawa, Hisao

2018-04-01

Rheology of a dilute cohesive granular gas is theoretically and numerically studied. The flow curve between the shear viscosity and the shear rate is derived from the inelastic Boltzmann equation for particles having square-well potentials in a simple shear flow. It is found that (i) the stable uniformly sheared state only exists above a critical shear rate and (ii) the viscosity in the uniformly sheared flow is almost identical to that for uniformly sheared flow of hard core granular particles. Below the critical shear rate, clusters grow with time, in which the viscosity can be approximated by that for the hard-core fluids if we replace the diameter of the particle by the mean diameter of clusters.

Exact solutions for oscillatory shear sweep behaviors of complex fluids from the Oldroyd 8-constant framework

NASA Astrophysics Data System (ADS)

Saengow, Chaimongkol; Giacomin, A. Jeffrey

2018-03-01

In this paper, we provide a new exact framework for analyzing the most commonly measured behaviors in large-amplitude oscillatory shear flow (LAOS), a popular flow for studying the nonlinear physics of complex fluids. Specifically, the strain rate sweep (also called the strain sweep) is used routinely to identify the onset of nonlinearity. By the strain rate sweep, we mean a sequence of LAOS experiments conducted at the same frequency, performed one after another, with increasing shear rate amplitude. In this paper, we give exact expressions for the nonlinear complex viscosity and the corresponding nonlinear complex normal stress coefficients, for the Oldroyd 8-constant framework for oscillatory shear sweeps. We choose the Oldroyd 8-constant framework for its rich diversity of popular special cases (we list 18 of these). We evaluate the Fourier integrals of our previous exact solution to get exact expressions for the real and imaginary parts of the complex viscosity, and for the complex normal stress coefficients, as functions of both test frequency and shear rate amplitude. We explore the role of infinite shear rate viscosity on strain rate sweep responses for the special case of the corotational Jeffreys fluid. We find that raising η∞ raises the real part of the complex viscosity and lowers the imaginary. In our worked examples, we thus first use the corotational Jeffreys fluid, and then, for greater accuracy, we use the Johnson-Segalman fluid, to describe the strain rate sweep response of molten atactic polystyrene. For our comparisons with data, we use the Spriggs relations to generalize the Oldroyd 8-constant framework to multimode. Our generalization yields unequivocally, a longest fluid relaxation time, used to assign Weissenberg and Deborah numbers to each oscillatory shear flow experiment. We then locate each experiment in the Pipkin space.

Design and implementation of a shearing apparatus for the experimental study of shear displacement in rocks

NASA Astrophysics Data System (ADS)

Moore, Johnathan; Crandall, Dustin; Gill, Magdalena; Brown, Sarah; Tennant, Bryan

2018-04-01

Fluid flow in the subsurface is not well understood in the context of "impermeable" geologic media. This is especially true of formations that have undergone significant stress fluctuations due to injection or withdrawal of fluids that alters the localized pressure regime. When the pressure regime is altered, these formations, which are often already fractured, move via shear to reduce the imbalance in the stress state. While this process is known to happen, the evolution of these fractures and their effects on fluid transport are still relatively unknown. Numerous simulation and several experimental studies have been performed that characterize the relationship between shearing and permeability in fractures; while many of these studies utilize measurements of fluid flow or the starting and ending geometries of the fracture to characterize shear, they do not characterize the intermediate stages during shear. We present an experimental apparatus based on slight modifications to a commonly available Hassler core holder that allows for shearing of rocks, while measuring the hydraulic and mechanical changes to geomaterials during intermediate steps. The core holder modification employs the use of semi-circular end caps and structural supports for the confining membrane that allow for free movement of the sheared material while preventing membrane collapse. By integrating this modified core holder with a computed tomography scanner, we show a new methodology for understanding the interdependent behavior between fracture structure and flow properties during intermediate steps in shearing. We include a case study of this device function which is shown here through shearing of a fractured shale core and simultaneous observation of the mechanical changes and evolution of the hydraulic properties during shearing.

Design and implementation of a shearing apparatus for the experimental study of shear displacement in rocks.

PubMed

Moore, Johnathan; Crandall, Dustin; Gill, Magdalena; Brown, Sarah; Tennant, Bryan

2018-04-01

Fluid flow in the subsurface is not well understood in the context of "impermeable" geologic media. This is especially true of formations that have undergone significant stress fluctuations due to injection or withdrawal of fluids that alters the localized pressure regime. When the pressure regime is altered, these formations, which are often already fractured, move via shear to reduce the imbalance in the stress state. While this process is known to happen, the evolution of these fractures and their effects on fluid transport are still relatively unknown. Numerous simulation and several experimental studies have been performed that characterize the relationship between shearing and permeability in fractures; while many of these studies utilize measurements of fluid flow or the starting and ending geometries of the fracture to characterize shear, they do not characterize the intermediate stages during shear. We present an experimental apparatus based on slight modifications to a commonly available Hassler core holder that allows for shearing of rocks, while measuring the hydraulic and mechanical changes to geomaterials during intermediate steps. The core holder modification employs the use of semi-circular end caps and structural supports for the confining membrane that allow for free movement of the sheared material while preventing membrane collapse. By integrating this modified core holder with a computed tomography scanner, we show a new methodology for understanding the interdependent behavior between fracture structure and flow properties during intermediate steps in shearing. We include a case study of this device function which is shown here through shearing of a fractured shale core and simultaneous observation of the mechanical changes and evolution of the hydraulic properties during shearing.

In situ monitoring of localized shear stress and fluid flow within developing tissue constructs by Doppler optical coherence tomography

NASA Astrophysics Data System (ADS)

Jia, Yali; Bagnaninchi, Pierre O.; Wang, Ruikang K.

2008-02-01

Mechanical stimuli can be introduced to three dimensional (3D) cell cultures by use of perfusion bioreactor. Especially in musculoskeletal tissues, shear stress caused by fluid flow generally increase extra-cellular matrix (ECM) production and cell proliferation. The relationship between the shear stress and the tissue development in situ is complicated because of the non-uniform pore distribution within the cell-seeded scaffold. In this study, we firstly demonstrated that Doppler optical coherence tomography (DOCT) is capable of monitoring localized fluid flow and shear stress in the complex porous scaffold by examining their variation trends at perfusion rate of 5, 8, 10 and 12 ml/hr. Then, we developed the 3D porous cellular constructs, cell-seeded chitosan scaffolds monitored during several days by DOCT. The fiber based fourier domain DOCT employed a 1300 nm superluminescent diode with a bandwidth of 52 nm and a xyz resolution of 20×20×15 μm in free space. This setup allowed us not only to assess the cell growth and ECM deposition by observing their different scattering behaviors but also to further investigate how the cell attachment and ECM production has the effect on the flow shear stress and the relationship between flow rate and shear stress in the developing tissue construct. The possibility to monitor continuously the constructs under perfusion will easily indicate the effect of flow rate or shear stress on the cell viability and cell proliferation, and then discriminate the perfusion parameters affecting the pre-tissue formation rate growth.

The fluid dynamics of the chocolate fountain

NASA Astrophysics Data System (ADS)

Townsend, Adam K.; Wilson, Helen J.

2016-01-01

We consider the fluid dynamics of the chocolate fountain. Molten chocolate is a mildly shear-thinning non-Newtonian fluid. Dividing the flow into three main domains—the pumped flow up the centre, the film flow over each dome, and the freely falling curtain flow between the domes—we generate a wide-ranging study of Newtonian and non-Newtonian fluid mechanics. The central pumped flow is a benchmark to elucidate the effects of shear-thinning. The dome flow can be modelled as a thin-film flow with the leading-order effects being a simple balance of gravity and viscosity. Finally, the curtain flow is analytically intractable but is related to the existing theory of water bells (both inviscid and viscous). In pipe flow, Newtonian fluids exhibit a parabolic velocity profile; shear-thinning makes the profile more blunted. In thin-film flow over the dome, gravitational and viscous effects balance and the dome shape is not important beyond the local slope. We find that the chocolate thins and slows down as it travels down the dome. Finally, in the curtain flow, we predict the shape of the falling sheet for an inviscid fluid, and compare this with the literature to predict the shape for a viscous fluid, having shown that viscous forces are too great to ignore. We also find that the primary effect driving the shape of the curtain (which falls inwards towards the axis of the fountain) is surface tension. We find that the three domains provide excellent introductions to non-Newtonian mechanics, the important mathematical technique of scaling, and how to manipulate existing data to make our own predictions. We also find that the topic generates interest among the public in our engagement work.

Shear Stress Sensing using Elastomer Micropillar Arrays

NASA Technical Reports Server (NTRS)

Wohl, Christopher J.; Palmieri, Frank L.; Lin, Yi; Jackson, Allen M.; Cissoto, Alexxandra; Sheplak, Mark; Connell, John W.

2013-01-01

The measurement of shear stress developed as a fluid moves around a solid body is difficult to measure. Stresses at the fluid-solid interface are very small and the nature of the fluid flow is easily disturbed by introducing sensor components to the interface. To address these challenges, an array of direct and indirect techniques have been investigated with various advantages and challenges. Hot wire sensors and other indirect sensors all protrude significantly into the fluid flow. Microelectromechanical systems (MEMS) devices, although facilitating very accurate measurements, are not durable, are prone to contamination, and are difficult to implement into existing model geometries. One promising approach is the use of engineered surfaces that interact with fluid flow in a detectable manner. To this end, standard lithographic techniques have been utilized to generate elastomeric micropillar arrays of various lengths and diameters. Micropillars of controlled length and width were generated in polydimethylsiloxane (PDMS) elastomer using a soft-lithography technique. The 3D mold for micropillar replication was fabricated using laser ablative micromachining and contact lithography. Micropillar dimensions and mechanical properties were characterized and compared to shear sensing requirements. The results of this characterization as well as shear stress detection techniques will be discussed.

Non-Newtonian particulate flow simulation: A direct-forcing immersed boundary-lattice Boltzmann approach

NASA Astrophysics Data System (ADS)

Amiri Delouei, A.; Nazari, M.; Kayhani, M. H.; Kang, S. K.; Succi, S.

2016-04-01

In the current study, a direct-forcing immersed boundary-non-Newtonian lattice Boltzmann method (IB-NLBM) is developed to investigate the sedimentation and interaction of particles in shear-thinning and shear-thickening fluids. In the proposed IB-NLBM, the non-linear mechanics of non-Newtonian particulate flows is detected by combination of the most desirable features of immersed boundary and lattice Boltzmann methods. The noticeable roles of non-Newtonian behavior on particle motion, settling velocity and generalized Reynolds number are investigated by simulating benchmark problem of one-particle sedimentation under the same generalized Archimedes number. The effects of extra force due to added accelerated mass are analyzed on the particle motion which have a significant impact on shear-thinning fluids. For the first time, the phenomena of interaction among the particles, such as Drafting, Kissing, and Tumbling in non-Newtonian fluids are investigated by simulation of two-particle sedimentation and twelve-particle sedimentation. The results show that increasing the shear-thickening behavior of fluid leads to a significant increase in the kissing time. Moreover, the transverse position of particles for shear-thinning fluids during the tumbling interval is different from Newtonian and the shear-thickening fluids. The present non-Newtonian particulate study can be applied in several industrial and scientific applications, like the non-Newtonian sedimentation behavior of particles in food industrial and biological fluids.

Elements of an improved model of debris‐flow motion

USGS Publications Warehouse

Iverson, Richard M.

2009-01-01

A new depth‐averaged model of debris‐flow motion describes simultaneous evolution of flow velocity and depth, solid and fluid volume fractions, and pore‐fluid pressure. Non‐hydrostatic pore‐fluid pressure is produced by dilatancy, a state‐dependent property that links the depth‐averaged shear rate and volumetric strain rate of the granular phase. Pore‐pressure changes caused by shearing allow the model to exhibit rate‐dependent flow resistance, despite the fact that the basal shear traction involves only rate‐independent Coulomb friction. An analytical solution of simplified model equations shows that the onset of downslope motion can be accelerated or retarded by pore‐pressure change, contingent on whether dilatancy is positive or negative. A different analytical solution shows that such effects will likely be muted if downslope motion continues long enough, because dilatancy then evolves toward zero, and volume fractions and pore pressure concurrently evolve toward steady states.

Elements of an improved model of debris-flow motion

USGS Publications Warehouse

Iverson, R.M.

2009-01-01

A new depth-averaged model of debris-flow motion describes simultaneous evolution of flow velocity and depth, solid and fluid volume fractions, and pore-fluid pressure. Non-hydrostatic pore-fluid pressure is produced by dilatancy, a state-dependent property that links the depth-averaged shear rate and volumetric strain rate of the granular phase. Pore-pressure changes caused by shearing allow the model to exhibit rate-dependent flow resistance, despite the fact that the basal shear traction involves only rate-independent Coulomb friction. An analytical solution of simplified model equations shows that the onset of downslope motion can be accelerated or retarded by pore-pressure change, contingent on whether dilatancy is positive or negative. A different analytical solution shows that such effects will likely be muted if downslope motion continues long enough, because dilatancy then evolves toward zero, and volume fractions and pore pressure concurrently evolve toward steady states. ?? 2009 American Institute of Physics.

Study of toluene rotary fluid management device and shear flow condenser performance for a space-based organic Rankine power system

NASA Technical Reports Server (NTRS)

Havens, Vance; Ragaller, Dana

1988-01-01

Management of two-phase fluid and control of the heat transfer process in microgravity is a technical challenge that must be addressed for an orbital Organic Rankine Cycle (ORC) application. A test program was performed in 1-g that satisfactorily demonstrated the two-phase management capability of the rotating fluid management device (RFMD) and shear-flow condenser. Operational tests of the RFMD and shear flow condenser in adverse gravity orientations, confirmed that the centrifugal forces in the RFMD and the shear forces in the condenser were capable of overcoming gravity forces. In a microgravity environment, these same forces would not have to compete against gravity and would therefore be dominant. The specific test program covered the required operating range of the Space Station Solar Dynamic Rankine Cycle power system. Review of the test data verified that: fluid was pumped from the RFMD in all attitudes; subcooled states in the condenser were achieved; condensate was pushed uphill against gravity; and noncondensible gases were swept through the condenser.

Scaling behavior of immersed granular flows

NASA Astrophysics Data System (ADS)

Amarsid, L.; Delenne, J.-Y.; Mutabaruka, P.; Monerie, Y.; Perales, F.; Radjai, F.

2017-06-01

The shear behavior of granular materials immersed in a viscous fluid depends on fluid properties (viscosity, density), particle properties (size, density) and boundary conditions (shear rate, confining pressure). Using computational fluid dynamics simulations coupled with molecular dynamics for granular flow, and exploring a broad range of the values of parameters, we show that the parameter space can be reduced to a single parameter that controls the packing fraction and effective friction coefficient. This control parameter is a modified inertial number that incorporates viscous effects.

Effects of Fluid Shear Stress on Cancer Stem Cell Viability

NASA Astrophysics Data System (ADS)

Sunday, Brittney; Triantafillu, Ursula; Domier, Ria; Kim, Yonghyun

2014-11-01

Cancer stem cells (CSCs), which are believed to be the source of tumor formation, are exposed to fluid shear stress as a result of blood flow within the blood vessels. It was theorized that CSCs would be less susceptible to cell death than non-CSCs after both types of cell were exposed to a fluid shear stress, and that higher levels of fluid shear stress would result in lower levels of cell viability for both cell types. To test this hypothesis, U87 glioblastoma cells were cultured adherently (containing smaller populations of CSCs) and spherically (containing larger populations of CSCs). They were exposed to fluid shear stress in a simulated blood flow through a 125-micrometer diameter polyetheretherketone (PEEK) tubing using a syringe pump. After exposure, cell viability data was collected using a BioRad TC20 Automated Cell Counter. Each cell type was tested at three physiological shear stress values: 5, 20, and 60 dynes per centimeter squared. In general, it was found that the CSC-enriched U87 sphere cells had higher cell viability than the CSC-depleted U87 adherent cancer cells. Interestingly, it was also observed that the cell viability was not negatively affected by the higher fluid shear stress values in the tested range. In future follow-up studies, higher shear stresses will be tested. Furthermore, CSCs from different tumor origins (e.g. breast tumor, prostate tumor) will be tested to determine cell-specific shear sensitivity. National Science Foundation Grant #1358991 supported the first author as an REU student.

Designing shear-thinning

NASA Astrophysics Data System (ADS)

Nelson, Arif Z.; Ewoldt, Randy H.

2017-11-01

Design in fluid mechanics often focuses on optimizing geometry (airfoils, surface textures, microfluid channels), but here we focus on designing fluids themselves. The dramatically shear-thinning ``yield-stress fluid'' is currently the most utilized non-Newtonian fluid phenomenon. These rheologically complex materials, which undergo a reversible transition from solid-like to liquid-like fluid flow, are utilized in pedestrian products such as paint and toothpaste, but also in emerging applications like direct-write 3D printing. We present a paradigm for yield-stress fluid design that considers constitutive model representation, material property databases, available predictive scaling laws, and the many ways to achieve a yield stress fluid, flipping the typical structure-to-rheology analysis to become the inverse: rheology-to-structure with multiple possible materials as solutions. We describe case studies of 3D printing inks and other flow scenarios where designed shear-thinning enables performance remarkably beyond that of Newtonian fluids. This work was supported by Wm. Wrigley Jr. Company and the National Science Foundation under Grant No. CMMI-1463203.

ESTIMATION OF SHEAR STRESS WORKING ON SUBMERGED HOLLOW FIBRE MEMBRANE BY CFD METHOD IN MBRs

NASA Astrophysics Data System (ADS)

Zaw, Hlwan Moe; Li, Tairi; Nagaoka, Hiroshi

This study was conducted to evaluate shear stress working on submerged hollow fibre membrane by CFD (Computation Fluid Dynamics) method in MBRs. Shear stress on hollow fibre membrane caused by aeration was measured directly using a two-direction load sensor. The measurement of water-phase flow velocity was done also by using laser doppler velocimeter. It was confirmed that the shear stress was possible to be evaluated from the water-phase flow velocityby the result of comparison of time average shear stress actually measured with one hollow fibre membrane and the one calculated by the water-phase flow velocity. In the estimation of the water-phase flow velocity using the CFD method, time average water-phase flow velocity estimated by consideration of the fluid resistance of the membrane module nearly coincided with the measured values, and it was shown that it was possible to be estimated also within the membrane module. Moreover, the measured shear stress and drag force well coincided with the values calculated from the estimated water-phase flow velocity outside of membrane module and in the center of membrane module, and it was suggested that the shear stress on the hollow fibre membrane could be estimated by the CFD method in MBRs.

Mathematical modeling of pulsatile flow of non-Newtonian fluid in stenosed arteries

NASA Astrophysics Data System (ADS)

Sankar, D. S.; Lee, Usik

2009-07-01

The pulsatile flow of blood through mild stenosed artery is studied. The effects of pulsatility, stenosis and non-Newtonian behavior of blood, treating the blood as Herschel-Bulkley fluid, are simultaneously considered. A perturbation method is used to analyze the flow. The expressions for the shear stress, velocity, flow rate, wall shear stress, longitudinal impedance and the plug core radius have been obtained. The variations of these flow quantities with different parameters of the fluid have been analyzed. It is found that, the plug core radius, pressure drop and wall shear stress increase with the increase of yield stress or the stenosis height. The velocity and the wall shear stress increase considerably with the increase in the amplitude of the pressure drop. It is clear that for a given value of stenosis height and for the increasing values of the stenosis shape parameter from 3 to 6, there is a sharp increase in the impedance of the flow and also the plots are skewed to the right-hand side. It is observed that the estimates of the increase in the longitudinal impedance increase with the increase of the axial distance or with the increase of the stenosis height. The present study also brings out the effects of asymmetric of the stenosis on the flow quantities.

Parallel-plate Flow Chamber and Continuous Flow Circuit to Evaluate Endothelial Progenitor Cells under Laminar Flow Shear Stress

PubMed Central

Lane, Whitney O.; Jantzen, Alexandra E.; Carlon, Tim A.; Jamiolkowski, Ryan M.; Grenet, Justin E.; Ley, Melissa M.; Haseltine, Justin M.; Galinat, Lauren J.; Lin, Fu-Hsiung; Allen, Jason D.; Truskey, George A.; Achneck, Hardean E.

2012-01-01

The overall goal of this method is to describe a technique to subject adherent cells to laminar flow conditions and evaluate their response to well quantifiable fluid shear stresses1. Our flow chamber design and flow circuit (Fig. 1) contains a transparent viewing region that enables testing of cell adhesion and imaging of cell morphology immediately before flow (Fig. 11A, B), at various time points during flow (Fig. 11C), and after flow (Fig. 11D). These experiments are illustrated with human umbilical cord blood-derived endothelial progenitor cells (EPCs) and porcine EPCs2,3. This method is also applicable to other adherent cell types, e.g. smooth muscle cells (SMCs) or fibroblasts. The chamber and all parts of the circuit are easily sterilized with steam autoclaving. In contrast to other chambers, e.g. microfluidic chambers, large numbers of cells (> 1 million depending on cell size) can be recovered after the flow experiment under sterile conditions for cell culture or other experiments, e.g. DNA or RNA extraction, or immunohistochemistry (Fig. 11E), or scanning electron microscopy5. The shear stress can be adjusted by varying the flow rate of the perfusate, the fluid viscosity, or the channel height and width. The latter can reduce fluid volume or cell needs while ensuring that one-dimensional flow is maintained. It is not necessary to measure chamber height between experiments, since the chamber height does not depend on the use of gaskets, which greatly increases the ease of multiple experiments. Furthermore, the circuit design easily enables the collection of perfusate samples for analysis and/or quantification of metabolites secreted by cells under fluid shear stress exposure, e.g. nitric oxide (Fig. 12)6. PMID:22297325

Mechanisms for the Crystallization of ZBLAN

NASA Technical Reports Server (NTRS)

Ethridge, Edwin C.; Tucker, Dennis S.; Kaukler, William; Antar, Basil

2003-01-01

The objective of this ground based study is to test the hypothesis that shear thinning (the non-Newtonian response of viscosity to shear rate) is a viable mechanism to explain the observation of enhanced glass formation in numerous low-g experiments. In 1-g, fluid motion results from buoyancy forces and surface tension driven convection. This fluid flow will introduce shear in undercooled liquids in 1-g. In low-g it is known that fluid flows are greatly reduced so that the shear rate in fluids can be extremely low. It is believed that some fluids may have weak structure in the absence of flow. Very small shear rates could cause this structure to collapse in response to shear resulting in a lowering of the viscosity of the fluid. The hypothesis of this research is that: Shear thinning in undercooled liquids decreases the viscosity, increasing the rate of nucleation and crystallization of glass forming melts. Shear in the melt can be reduced in low-g, thus enhancing undercooling and glass formation. The viscosity of a model glass (lithium di-silicate, L2S) often used for crystallization studies has been measured at very low shear rates using a dynamic mechanical thermal analyzer. Our results are consistent with increasing viscosity with a lowering of shear rates. The viscosity of L2S may vary as much as an order of magnitude depending on the shear rate in the temperature region of maximum nucleation and crystal growth. Classical equations for nucleation and crystal growth rates, are inversely related to the viscosity and viscosity to the third power respectively. An order of magnitude variation in viscosity (with shear) at a given temperature would have dramatic effects on glass crystallization Crystallization studies with the heavy metal fluoride glass ZBLAN (ZrF2-BaF2-LaF3-AlF3-NaF) to examine the effect of shear on crystallization are being initiated. Samples are to be melted and quenched under quiescent conditions at different shear rates to determine the effect on crystallization. The results from this study are expected to advance the current scientific understanding of glass formation in low-g and glass crystallization under glass molding conditions and will improve the scientific understanding of technological processes such as fiber pulling, bulk amorphous alloys, and glass fabrication processes.

Computational analysis of integrated biosensing and shear flow in a microfluidic vascular model

NASA Astrophysics Data System (ADS)

Wong, Jeremy F.; Young, Edmond W. K.; Simmons, Craig A.

2017-11-01

Fluid flow and flow-induced shear stress are critical components of the vascular microenvironment commonly studied using microfluidic cell culture models. Microfluidic vascular models mimicking the physiological microenvironment also offer great potential for incorporating on-chip biomolecular detection. In spite of this potential, however, there are few examples of such functionality. Detection of biomolecules released by cells under flow-induced shear stress is a significant challenge due to severe sample dilution caused by the fluid flow used to generate the shear stress, frequently to the extent where the analyte is no longer detectable. In this work, we developed a computational model of a vascular microfluidic cell culture model that integrates physiological shear flow and on-chip monitoring of cell-secreted factors. Applicable to multilayer device configurations, the computational model was applied to a bilayer configuration, which has been used in numerous cell culture applications including vascular models. Guidelines were established that allow cells to be subjected to a wide range of physiological shear stress while ensuring optimal rapid transport of analyte to the biosensor surface and minimized biosensor response times. These guidelines therefore enable the development of microfluidic vascular models that integrate cell-secreted factor detection while addressing flow constraints imposed by physiological shear stress. Ultimately, this work will result in the addition of valuable functionality to microfluidic cell culture models that further fulfill their potential as labs-on-chips.

A Two-length Scale Turbulence Model for Single-phase Multi-fluid Mixing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schwarzkopf, J. D.; Livescu, D.; Baltzer, J. R.

2015-09-08

A two-length scale, second moment turbulence model (Reynolds averaged Navier-Stokes, RANS) is proposed to capture a wide variety of single-phase flows, spanning from incompressible flows with single fluids and mixtures of different density fluids (variable density flows) to flows over shock waves. The two-length scale model was developed to address an inconsistency present in the single-length scale models, e.g. the inability to match both variable density homogeneous Rayleigh-Taylor turbulence and Rayleigh-Taylor induced turbulence, as well as the inability to match both homogeneous shear and free shear flows. The two-length scale model focuses on separating the decay and transport length scales,more » as the two physical processes are generally different in inhomogeneous turbulence. This allows reasonable comparisons with statistics and spreading rates over such a wide range of turbulent flows using a common set of model coefficients. The specific canonical flows considered for calibrating the model include homogeneous shear, single-phase incompressible shear driven turbulence, variable density homogeneous Rayleigh-Taylor turbulence, Rayleigh-Taylor induced turbulence, and shocked isotropic turbulence. The second moment model shows to compare reasonably well with direct numerical simulations (DNS), experiments, and theory in most cases. The model was then applied to variable density shear layer and shock tube data and shows to be in reasonable agreement with DNS and experiments. Additionally, the importance of using DNS to calibrate and assess RANS type turbulence models is highlighted.« less

Effects of insulin on physical factors: atherosclerosis in diabetes mellitus.

PubMed

McMillan, D E

1985-12-01

Newton's laws of motion play a major role in blood flow. Inertia and conservation of momentum cause flow to separate at branches and curves in large blood vessels. Areas of separated flow in the arterial system are sites of atherogenesis. The place at which the separation ends, called the stagnation point, is the focus for plaque development. Pulsation of the arterial circulation causes the stagnation point to move downstream with each systole and upstream with each diastole. This movement generates forward and backward shearing force in the stagnation region as the separated flow migrates back and forth. Angular momentum, introduced into flowing blood with each heart beat and further enhanced by the asymmetry of origin of vessels branching from the aorta, generates a sidewise force component that is preserved during migration of the stagnation point. The sidewise force, added to the forward and backward shear stresses, creates an area of multidirectional shear stress under the migrating stagnation point that increases the permeability of the local endothelium. Blood is a complex fluid; it can generate greater shear stresses near the stagnation point than the simple fluids normally studied by fluid mechanicists. Blood is capable of retaining shear stress for short periods after it ceases to flow and extra work is required to establish its flow. In diabetes, reduced erythrocyte deformability further burdens flow onset. We are not yet able to establish whether the increase is only a few percent, or whether the burden is larger. Whatever its magnitude, diabetic modifications of the flow properties of blood, directly affect the size, location, and rate of development of atherosclerotic plaques.

Hydrodynamic interaction of two deformable drops in confined shear flow.

PubMed

Chen, Yongping; Wang, Chengyao

2014-09-01

We investigate hydrodynamic interaction between two neutrally buoyant circular drops in a confined shear flow based on a computational fluid dynamics simulation using the volume-of-fluid method. The rheological behaviors of interactive drops and the flow regimes are explored with a focus on elucidation of underlying physical mechanisms. We find that two types of drop behaviors during interaction occur, including passing-over motion and reversing motion, which are governed by the competition between the drag of passing flow and the entrainment of reversing flow in matrix fluid. With the increasing confinement, the drop behavior transits from the passing-over motion to reversing motion, because the entrainment of the reversing-flow matrix fluid turns to play the dominant role. The drag of the ambient passing flow is increased by enlarging the initial lateral separation due to the departure of the drop from the reversing flow in matrix fluid, resulting in the emergence of passing-over motion. In particular, a corresponding phase diagram is plotted to quantitatively illustrate the dependence of drop morphologies during interaction on confinement and initial lateral separation.

Observation of Droplet Size Oscillations in a Two-Phase Fluid under Shear Flow

NASA Astrophysics Data System (ADS)

Courbin, Laurent; Panizza, Pascal; Salmon, Jean-Baptiste

2004-01-01

Experimental observations of droplet size sustained oscillations are reported in a two-phase flow between a lamellar and a sponge phase. Under shear flow, this system presents two different steady states made of monodisperse multilamellar droplets, separated by a shear-thinning transition. At low and high shear rates, the droplet size results from a balance between surface tension and viscous stress, whereas for intermediate shear rates it becomes a periodic function of time. A possible mechanism for such kinds of oscillations is discussed.

On steady two-dimensional Carreau fluid flow over a wedge in the presence of infinite shear rate viscosity

NASA Astrophysics Data System (ADS)

Khan, Masood; Sardar, Humara

2018-03-01

This paper investigates the steady two-dimensional flow over a moving/static wedge in a Carreau viscosity model with infinite shear rate viscosity. Additionally, heat transfer analysis is performed. Using suitable transformations, nonlinear partial differential equations are transformed into ordinary differential equations and solved numerically using the Runge-Kutta Fehlberg method coupled with the shooting technique. The effects of various physical parameters on the velocity and temperature distributions are displayed graphically and discussed qualitatively. A comparison with the earlier reported results has been made with an excellent agreement. It is important to note that the increasing values of the wedge angle parameter enhance the fluid velocity while the opposite trend is observed for the temperature field for both shear thinning and thickening fluids. Generally, our results reveal that the velocity and temperature distributions are marginally influenced by the viscosity ratio parameter. Further, it is noted that augmented values of viscosity ratio parameter thin the momentum and thermal boundary layer thickness in shear thickening fluid and reverse is true for shear thinning fluid. Moreover, it is noticed that the velocity in case of moving wedge is higher than static wedge.

Boundary layers at the interface of two different shear flows

NASA Astrophysics Data System (ADS)

Weidman, Patrick D.; Wang, C. Y.

2018-05-01

We present solutions for the boundary layer between two uniform shear flows flowing in the same direction. In the upper layer, the flow has shear strength a, fluid density ρ1, and kinematic viscosity ν1, while the lower layer has shear strength b, fluid density ρ2, and kinematic viscosity ν2. Similarity transformations reduce the boundary-layer equations to a pair of ordinary differential equations governed by three dimensionless parameters: the shear strength ratio γ = b/a, the density ratio ρ = ρ2/ρ1, and the viscosity ratio ν = ν2/ν1. Further analysis shows that an affine transformation reduces this multi-parameter problem to a single ordinary differential equation which may be efficiently integrated as an initial-value problem. Solutions of the original boundary-value problem are shown to agree with the initial-value integrations, but additional dual and quadruple solutions are found using this method. We argue on physical grounds and through bifurcation analysis that these additional solutions are not tenable. The present problem is applicable to the trailing edge flow over a thin airfoil with camber.

Transient Droplet Behavior and Droplet Breakup during Bulk and Confined Shear Flow in Blends with One Viscoelastic Component: Experiments, Modelling and Simulations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cardinaels, Ruth; Verhulst, Kristof; Moldenaers, Paula

2008-07-07

The transient droplet deformation and droplet orientation after inception of shear, the shape relaxation after cessation of shear and droplet breakup during shear, are microscopically studied, both under bulk and confined conditions. The studied blends contain one viscoelastic Boger fluid phase. A counter rotating setup, based on a Paar Physica MCR300, is used for the droplet visualisation. For bulk shear flow, it is shown that the droplet deformation during startup of shear flow and the shape relaxation after cessation of shear flow are hardly influenced by droplet viscoelasticity, even at moderate to high capillary and Deborah numbers. The effects ofmore » droplet viscoelasticity only become visible close to the critical conditions and a novel break-up mechanism is observed. Matrix viscoelasticity has a more pronounced effect, causing overshoots in the deformation and significantly inhibiting relaxation. However, different applied capillary numbers prior to cessation of shear flow, with the Deborah number fixed, still result in a single master curve for shape retraction, as in fully Newtonian systems. The long tail in the droplet relaxation can be qualitatively described with a phenomenological model for droplet deformation, when using a 5-mode Giesekus model for the fluid rheology. It is found that the shear flow history significantly affects the droplet shape evolution and the breakup process in blends with one viscoelastic component. Confining a droplet between two plates accelerates the droplet deformation kinetics, similar to fully Newtonian systems. However, the increased droplet deformation, due to wall effects, causes the steady state to be reached at a later instant in time. Droplet relaxation is less sensitive to confinement, leading to slower relaxation kinetics only for highly confined droplets. For the blend with a viscoelastic droplet, a non-monotonous trend is found for the critical capillary number as a function of the confinement ratio. Finally, experimental data are compared with 3D simulations, performed with a volume-of-fluid algorithm.« less

Enhanced Remedial Amendment Delivery to Subsurface Using Shear Thinning Fluid and Aqueous Foam

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhong, Lirong; Szecsody, James E.; Oostrom, Martinus

2011-04-23

A major issue with in situ subsurface remediation is the ability to achieve an even spatial distribution of remedial amendments to the contamination zones in an aquifer or vadose zone. Delivery of amendment to the aquifer using shear thinning fluid and to the vadose zone using aqueous foam has the potential to enhance the amendment distribution into desired locations and improve the remediation. 2-D saturated flow cell experiments were conducted to evaluate the enhanced sweeping, contaminant removal, and amendment persistence achieved by shear thinning fluid delivery. Bio-polymer xanthan gum solution was used as the shear thinning fluid. Unsaturated 1-D columnmore » and 2-D flow cell experiments were conducted to evaluate the mitigation of contaminant mobilization, amendment uniform distribution enhancement, and lateral delivery improvement by foam delivery. Surfactant sodium lauryl ether sulfate was used as the foaming agent. It was demonstrated that the shear thinning fluid injection enhanced the fluid sweeping over a heterogeneous system and increased the delivery of remedial amendment into low-permeability zones. The persistence of the amendment distributed into the low-perm zones by the shear thinning fluid was prolonged compared to that of amendment distributed by water injection. Foam delivery of amendment was shown to mitigate the mobilization of highly mobile contaminant from sediments under vadose zone conditions. Foam delivery also achieved more uniform amendment distribution in a heterogeneous unsaturated system, and demonstrated remarkable increasing in lateral distribution of the injected liquid compared to direct liquid injection.« less

International Congress of Fluid Mechanics, 3rd, Cairo, Egypt, Jan. 2-4, 1990, Proceedings. Volumes 1, 2, 3, & 4

NASA Astrophysics Data System (ADS)

Nayfeh, A. H.; Mobarak, A.; Rayan, M. Abou

This conference presents papers in the fields of flow separation, unsteady aerodynamics, fluid machinery, boundary-layer control and stability, grid generation, vorticity dominated flows, and turbomachinery. Also considered are propulsion, waves and sound, rotor aerodynamics, computational fluid dynamics, Euler and Navier-Stokes equations, cavitation, mixing and shear layers, mixing layers and turbulent flows, and fluid machinery and two-phase flows. Also addressed are supersonic and reacting flows, turbulent flows, and thermofluids.

Two-stage fluid flow and element transfers in shear zones during collision burial-exhumation cycle: Insights from the Mont Blanc Crystalline Massif (Western Alps)

NASA Astrophysics Data System (ADS)

Rolland, Y.; Rossi, M.

2016-11-01

The Mont-Blanc Massif was intensely deformed during the Alpine orogenesis: in a first stage of prograde underthrusting at c. 30 Ma and in a second stage of uplift and exhumation at 22-11 Ma. Mid-crustal shear zones of 1 mm-50 m size, neighbouring episyenites (quartz-dissolved altered granite) and alpine veins, have localised intense fluid flow, which produced substantial changes in mineralogy and whole-rock geochemistry. Four main metamorphic zones are oriented parallel to the strike of the massif: (i) epidote, (ii) chlorite, (iii) actinolite-muscovite ± biotite and (iv) muscovite ± biotite. In addition, phlogopite-bearing shear zones occur in the chlorite zone, and calcite-bearing shear zones are locally found in the muscovite zone. The initial chemical composition of the granitic protolith is relatively constant at massif scale, which allows investigating compositional changes related to shear zone activity, and subsequent volume change and elements mobility. The variations of whole-rock composition and mineral chemistry in shear zones reflect variations in fluid/rock ratios and fluid's chemistry, which have produced specific mineral reactions. Estimated time-integrated fluid fluxes are of the order of 106 m3/m2. The mineral assemblages that crystallised upon these fluid-P-T conditions are responsible for specific major and trace element enrichments. The XFe (Fe/Fe + Mg) pattern of shear zone phyllosilicates and the δ13C pattern of vein calcite both show a bell-type pattern across the massif with high values on the massif rims and low values in the centre of the massif. These low XFe and δ13C values are explained by down temperature up-flow of a Fe-Mg-CO2-rich and silica-depleted fluid during stage 1, while the massif was underthrusting. These produced phlogopite, chlorite and actinolite precipitation and quartz hydrolysis, resulting in strong volume losses. In contrast, during stage 2 (uplift), substantial volume gains occurred on the massif rims due to the precipitation of quartz, epidote and muscovite from a local fluid hosted in the Helvetic cover. These two fluids advocate for the presence of an upper-crustal scaled fluid convection cell, with up-going fluids through the lower crust and likely down-going fluids in the 15 km upper crust.

Measurement of Wall Shear Stress in High Speed Air Flow Using Shear-Sensitive Liquid Crystal Coating.

PubMed

Zhao, Jisong

2018-05-17

Wall shear stress is an important quantity in fluid mechanics, but its measurement is a challenging task. An approach to measure wall shear stress vector distribution using shear-sensitive liquid crystal coating (SSLCC) is described. The wall shear stress distribution on the test surface beneath high speed jet flow is measured while using the proposed technique. The flow structures inside the jet flow are captured and the results agree well with the streakline pattern that was visualized using the oil-flow technique. In addition, the shock diamonds inside the supersonic jet flow are visualized clearly using SSLCC and the results are compared with the velocity contour that was measured using the particle image velocimetry (PIV) technique. The work of this paper demonstrates the application of SSLCC in the measurement/visualization of wall shear stress in high speed flow.

Measurement of Wall Shear Stress in High Speed Air Flow Using Shear-Sensitive Liquid Crystal Coating

PubMed Central

Zhao, Jisong

2018-01-01

Wall shear stress is an important quantity in fluid mechanics, but its measurement is a challenging task. An approach to measure wall shear stress vector distribution using shear-sensitive liquid crystal coating (SSLCC) is described. The wall shear stress distribution on the test surface beneath high speed jet flow is measured while using the proposed technique. The flow structures inside the jet flow are captured and the results agree well with the streakline pattern that was visualized using the oil-flow technique. In addition, the shock diamonds inside the supersonic jet flow are visualized clearly using SSLCC and the results are compared with the velocity contour that was measured using the particle image velocimetry (PIV) technique. The work of this paper demonstrates the application of SSLCC in the measurement/visualization of wall shear stress in high speed flow. PMID:29772822

Structural state diagram of concentrated suspensions of jammed soft particles in oscillatory shear flow

NASA Astrophysics Data System (ADS)

Khabaz, Fardin; Cloitre, Michel; Bonnecaze, Roger T.

2018-03-01

In a recent study [Khabaz et al., Phys. Rev. Fluids 2, 093301 (2017), 10.1103/PhysRevFluids.2.093301], we showed that jammed soft particle glasses (SPGs) crystallize and order in steady shear flow. Here we investigate the rheology and microstructures of these suspensions in oscillatory shear flow using particle-dynamics simulations. The microstructures in both types of flows are similar, but their evolutions are very different. In both cases the monodisperse and polydisperse suspensions form crystalline and layered structures, respectively, at high shear rates. The crystals obtained in the oscillatory shear flow show fewer defects compared to those in the steady shear. SPGs remain glassy for maximum oscillatory strains less than about the yield strain of the material. For maximum strains greater than the yield strain, microstructural and rheological transitions occur for SPGs. Polydisperse SPGs rearrange into a layered structure parallel to the flow-vorticity plane for sufficiently high maximum shear rates and maximum strains about 10 times greater than the yield strain. Monodisperse suspensions form a face-centered cubic (FCC) structure when the maximum shear rate is low and hexagonal close-packed (HCP) structure when the maximum shear rate is high. In steady shear, the transition from a glassy state to a layered one for polydisperse suspensions included a significant induction strain before the transformation. In oscillatory shear, the transformation begins to occur immediately and with different microstructural changes. A state diagram for suspensions in large amplitude oscillatory shear flow is found to be in close but not exact agreement with the state diagram for steady shear flow. For more modest amplitudes of around one to five times the yield strain, there is a transition from a glassy structure to FCC and HCP crystals, at low and high frequencies, respectively, for monodisperse suspensions. At moderate frequencies, the transition is from glassy to HCP via an intermediate FCC phase.

Experimental and CFD flow studies in an intracranial aneurysm model with Newtonian and non-Newtonian fluids.

PubMed

Frolov, S V; Sindeev, S V; Liepsch, D; Balasso, A

2016-05-18

According to the clinical data, flow conditions play a major role in the genesis of intracranial aneurysms. The disorder of the flow structure is the cause of damage of the inner layer of the vessel wall, which leads to the development of cerebral aneurysms. Knowledge of the alteration of the flow field in the aneurysm region is important for treatment. The aim is to study quantitatively the flow structure in an patient-specific aneurysm model of the internal carotid artery using both experimental and computational fluid dynamics (CFD) methods with Newtonian and non-Newtonian fluids. A patient-specific geometry of aneurysm of the internal carotid artery was used. Patient data was segmented and smoothed to obtain geometrical model. An elastic true-to-scale silicone model was created with stereolithography. For initial investigation of the blood flow, the flow was visualized by adding particles into the silicone model. The precise flow velocity measurements were done using 1D Laser Doppler Anemometer with a spatial resolution of 50 μ m and a temporal resolution of 1 ms. The local velocity measurements were done at a distance of 4 mm to each other. A fluid with non-Newtonian properties was used in the experiment. The CFD simulations for unsteady-state problem were done using constructed hexahedral mesh for Newtonian and non-Newtonian fluids. Using 1D laser Doppler Anemometer the minimum velocity magnitude at the end of systole -0.01 m/s was obtained in the aneurysm dome while the maximum velocity 1 m/s was at the center of the outlet segment. On central cross section of the aneurysm the maximum velocity value is only 20% of the average inlet velocity. The average velocity on the cross-section is only 11% of the inlet axial velocity. Using the CFD simulation the wall shear stresses for Newtonian and non-Newtonian fluid at the end of systolic phase (t= 0.25 s) were computed. The wall shear stress varies from 3.52 mPa (minimum value) to 10.21 Pa (maximum value) for the Newtonian fluid. For the non-Newtonian fluid the wall shear stress minimum is 2.94 mPa; the maximum is 9.14 Pa. The lowest value of the wall shear stress for both fluids was obtained at the dome of the aneurysm while the highest wall shear stress was at the beginning of the outlet segment. The vortex in the aneurysm region is unstable during the cardiac cycle. The clockwise rotation of the streamlines at the inlet segment for Newtonian and non-Newtonian fluid is shown. The results of the present study are in agreement with the hemodynamics theory of aneurysm genesis. Low value of wall shear stress is observed at the aneurysm dome which can cause a rupture of an aneurysm.

Direct numerical simulations of agglomeration of circular colloidal particles in two-dimensional shear flow

DOE Office of Scientific and Technical Information (OSTI.GOV)

Choi, Young Joon, E-mail: yjchoi@uvic.ca; Djilali, Ned, E-mail: ndjilali@uvic.ca

2016-01-15

Colloidal agglomeration of nanoparticles in shear flow is investigated by solving the fluid-particle and particle-particle interactions in a 2D system. We use an extended finite element method in which the dynamics of the particles is solved in a fully coupled manner with the flow, allowing an accurate description of the fluid-particle interfaces without the need of boundary-fitted meshes or of empirical correlations to account for the hydrodynamic interactions between the particles. Adaptive local mesh refinement using a grid deformation method is incorporated with the fluid-structure interaction algorithm, and the particle-particle interaction at the microscopic level is modeled using the Lennard-Jonesmore » potential. Motivated by the process used in fabricating fuel cell catalysts from a colloidal ink, the model is applied to investigate agglomeration of colloidal particles under external shear flow in a sliding bi-periodic Lees-Edwards frame with varying shear rates and particle fraction ratios. Both external shear and particle fraction are found to have a crucial impact on the structure formation of colloidal particles in a suspension. Segregation intensity and graph theory are used to analyze the underlying agglomeration patterns and structures, and three agglomeration regimes are identified.« less

Effects of coarse grain size distribution and fine particle content on pore fluid pressure and shear behavior in experimental debris flows

NASA Astrophysics Data System (ADS)

Kaitna, Roland; Palucis, Marisa C.; Yohannes, Bereket; Hill, Kimberly M.; Dietrich, William E.

2016-02-01

Debris flows are typically a saturated mixture of poorly sorted particles and interstitial fluid, whose density and flow properties depend strongly on the presence of suspended fine sediment. Recent research suggests that grain size distribution (GSD) influences excess pore pressures (i.e., pressure in excess of predicted hydrostatic pressure), which in turn plays a governing role in debris flow behaviors. We report a series of controlled laboratory experiments in a 4 m diameter vertically rotating drum where the coarse particle size distribution and the content of fine particles were varied independently. We measured basal pore fluid pressures, pore fluid pressure profiles (using novel sensor probes), velocity profiles, and longitudinal profiles of the flow height. Excess pore fluid pressure was significant for mixtures with high fines fraction. Such flows exhibited lower values for their bulk flow resistance (as measured by surface slope of the flow), had damped fluctuations of normalized fluid pressure and normal stress, and had velocity profiles where the shear was concentrated at the base of the flow. These effects were most pronounced in flows with a wide coarse GSD distribution. Sustained excess fluid pressure occurred during flow and after cessation of motion. Various mechanisms may cause dilation and contraction of the flows, and we propose that the sustained excess fluid pressures during flow and once the flow has stopped may arise from hindered particle settling and yield strength of the fluid, resulting in transfer of particle weight to the fluid. Thus, debris flow behavior may be strongly influenced by sustained excess fluid pressures controlled by particle settling rates.

Shear-induced intracellular loading of cells with molecules by controlled microfluidics.

PubMed

Hallow, Daniel M; Seeger, Richard A; Kamaev, Pavel P; Prado, Gustavo R; LaPlaca, Michelle C; Prausnitz, Mark R

2008-03-01

This study tested the hypothesis that controlled flow through microchannels can cause shear-induced intracellular loading of cells with molecules. The overall goal was to design a simple device to expose cells to fluid shear stress and thereby increase plasma membrane permeability. DU145 prostate cancer cells were exposed to fluid shear stress in the presence of fluorescent cell-impermeant molecules by using a cone-and-plate shearing device or high-velocity flow through microchannels. Using a syringe pump, cell suspensions were flowed through microchannels of 50-300 microm diameter drilled through Mylar sheets using an excimer laser. As quantified by flow cytometry, intracellular uptake and loss of viability correlated with the average shear stress. Optimal results were observed when exposing the cells to high shear stress for short durations in conical channels, which yielded uptake to over one-third of cells while maintaining viability at approximately 80%. This method was capable of loading cells with molecules including calcein (0.62 kDa), large molecule weight dextrans (150-2,000 kDa), and bovine serum albumin (66 kDa). These results supported the hypothesis that shear-induced intracellular uptake could be generated by flow of cell suspensions through microchannels and further led to the design of a simple, inexpensive, and effective device to deliver molecules into cells. Such a device could benefit biological research and the biotechnology industry. Copyright 2007 Wiley Periodicals, Inc.

Shear-induced intracellular loading of cells with molecules by controlled microfluidics

PubMed Central

Hallow, Daniel M.; Seeger, Richard A.; Kamaev, Pavel P.; Prado, Gustavo R.; LaPlaca, Michelle C.; Prausnitz, Mark R.

2010-01-01

This study tested the hypothesis that controlled flow through microchannels can cause shear-induced intracellular loading of cells with molecules. The overall goal was to design a simple device to expose cells to fluid shear stress and thereby increase plasma membrane permeability. DU145 prostate cancer cells were exposed to fluid shear stress in the presence of fluorescent cell-impermeant molecules by using a cone-and-plate shearing device or high-velocity flow through microchannels. Using a syringe pump, cell suspensions were flowed through microchannels of 50 – 300 μm diameter drilled through Mylar® sheets using an excimer laser. As quantified by flow cytometry, intracellular uptake and loss of viability correlated with the average shear stress. Optimal results were observed when exposing the cells to high shear stress for short durations in conical channels, which yielded uptake to over one third of cells while maintaining viability at approximately 80%. This method was capable of loading cells with molecules including calcein (0.62 kDa), large molecule weight dextrans (150 - 2000 kDa), and bovine serum albumin (66 kDa). These results supported the hypothesis that shear-induced intracellular uptake could be generated by flow of cell suspensions through microchannels and further led to the design of a simple, inexpensive, and effective device to deliver molecules into cells. Such a device could benefit biological research and the biotechnology industry. PMID:17879304

Fluid flow stimulates rapid and continuous release of nitric oxide in osteoblasts

NASA Technical Reports Server (NTRS)

Johnson, D. L.; McAllister, T. N.; Frangos, J. A.

1996-01-01

Interstitial fluid flow may mediate skeletal remodeling in response to mechanical loading. Because nitric oxide (NO) has been shown to be an osteoblast mitogen and inhibitor of osteoclastic resorption, we investigated and characterized the role of fluid shear on the release of NO in osteoblasts. Rat calvarial cells in a stationary culture produced undetectable levels of NO. Fluid shear stress (6 dyn/cm2) rapidly increased NO release rate to 9.8 nmol.h-1.mg protein-1 and sustained this production for 12 h of exposure to flow. Cytokine treatment also induced NO synthesis after a 12-h lag phase of zero production, followed by a production rate of 0.6 nmol.h-1.mg protein-1. Flow-induced NO production was blocked by the NO synthase (NOS) inhibitor NG-amino-L-arginine, but not by dexamethasone, which suggests that the flow stimulated a constitutive NOS isoform. This is the first time that a functional constitutively present NOS isoform has been identified in osteoblasts. Moreover, fluid flow represents the most potent stimulus of NO release in osteoblasts reported to date. Fluid flow-induced NO production may therefore play a primary role in bone maintenance and remodeling.

Numerical simulation of the non-Newtonian blood flow through a mechanical aortic valve. Non-Newtonian blood flow in the aortic root

NASA Astrophysics Data System (ADS)

De Vita, F.; de Tullio, M. D.; Verzicco, R.

2016-04-01

This work focuses on the comparison between Newtonian and non-Newtonian blood flows through a bileaflet mechanical heart valve in the aortic root. The blood, in fact, is a concentrated suspension of cells, mainly red blood cells, in a Newtonian matrix, the plasma, and consequently its overall behavior is that of a non-Newtonian fluid owing to the action of the cells' membrane on the fluid part. The common practice, however, assumes the blood in large vessels as a Newtonian fluid since the shear rate is generally high and the effective viscosity becomes independent of the former. In this paper, we show that this is not always the case even in the aorta, the largest artery of the systemic circulation, owing to the pulsatile and transitional nature of the flow. Unexpectedly, for most of the pulsating cycle and in a large part of the fluid volume, the shear rate is smaller than the threshold level for the blood to display a constant effective viscosity and its shear thinning character might affect the system dynamics. A direct inspection of the various flow features has shown that the valve dynamics, the transvalvular pressure drop and the large-scale features of the flow are very similar for the Newtonian and non-Newtonian fluid models. On the other hand, the mechanical damage of the red blood cells (hemolysis), induced by the altered stress values in the flow, is larger for the non-Newtonian fluid model than for the Newtonian one.

Two-fluid equilibrium transition during multi-pulsing CHI in spherical torus

NASA Astrophysics Data System (ADS)

Kanki, T.; Nagata, M.

2015-11-01

Two-fluid dynamo current drive has been studied to achieve a quasi-steady sustainment and good confinement of spherical torus (ST) plasmas by multi-pulsing CHI (M-CHI) in the HIST device. The density gradient, poloidal flow shear, and radial electric shear enhanced by applying the second CHI pulse is observed around the separatrix in the high field side to cause not only the ExB drift but also the ion diamagnetic drift, leading the two-fluid dynamo. The two-fluid equilibrium transition during the M-CHI in the ST is investigated by modelling the M-CHI in the two-fluid equilibrium calculations. The toroidal magnetic field becomes from a diamagnetic to a paramagnetic profile in the closed flux region due to the increase of the poloidal electron flow velocity in the central open flux column (OFC) region, while the diamagnetic profile is kept in the OFC region. The toroidal ion flow velocity is increased from negative to positive values in the closed flux region due to the increase in the drift velocity and the Hall effect. As the ion diamagnetic drift velocity is changed in the same direction as the ExB drift velocity around the separatrix in the high field side through the negative ion pressure gradient there, the poloidal ion flow velocity is increased in the OFC region, enhancing the flow shear. The radial electric field shear around the separatrix is enhanced due to the strong dependence on the magnetic force through the interaction of toroidal ion flow velocity and axial magnetic field. The density is decreased in the closed flux region according to the generalized Bernoulli law and its negative gradient around the separatrix steepens.

Models of non-Newtonian Hele-Shaw flow

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kondic, L.; Palffy-Muhoray, P.; Shelley, M.J.

1996-11-01

We study the Saffman-Taylor instability of a non-Newtonian fluid in a Hele-Shaw cell. Using a fluid model with shear-rate dependent viscosity, we derive a Darcy{close_quote}s law whose viscosity depends upon the squared pressure gradient. This yields a natural, nonlinear boundary value problem for the pressure. A model proposed recently by Bonn {ital et} {ital al}. [Phys. Rev. Lett. {bold 75}, 2132 (1995)] follows from this modified law. For a shear-thinning liquid, our derivation shows strong constraints upon the fluid viscosity{emdash} strong shear-thinning does not allow the construction of a unique Darcy{close_quote}s law, and is related to the appearance of slipmore » layers in the flow. For a weakly shear-thinning liquid, we calculate corrections to the Newtonian instability of an expanding bubble in a radial cell. {copyright} {ital 1996 The American Physical Society.}« less

Edge Fracture in Complex Fluids.

PubMed

Hemingway, Ewan J; Kusumaatmaja, Halim; Fielding, Suzanne M

2017-07-14

We study theoretically the edge fracture instability in sheared complex fluids, by means of linear stability analysis and direct nonlinear simulations. We derive an exact analytical expression for the onset of edge fracture in terms of the shear-rate derivative of the fluid's second normal stress difference, the shear-rate derivative of the shear stress, the jump in shear stress across the interface between the fluid and the outside medium (usually air), the surface tension of that interface, and the rheometer gap size. We provide a full mechanistic understanding of the edge fracture instability, carefully validated against our simulations. These findings, which are robust with respect to choice of rheological constitutive model, also suggest a possible route to mitigating edge fracture, potentially allowing experimentalists to achieve and accurately measure flows stronger than hitherto possible.

Numerical simulation of fluid flow in a rotational bioreactor

NASA Astrophysics Data System (ADS)

Ganimedov, V. L.; Papaeva, E. O.; Maslov, N. A.; Larionov, P. M.

2017-10-01

Application of scaffold technology for the problem of bone tissue regeneration has great prospects in modern medicine. The influence of fluid shear stress on stem cells cultivation and its differentiation into osteoblasts is the subject of intensive research. Mathematical modeling of fluid flow in bioreactor allowed us to determine the structure of flow and estimate the level of mechanical stress on cells. The series of computations for different rotation frequencies (0.083, 0.124, 0.167, 0.2 and 0.233 Hz) was performed for the laminar flow regime approximation. It was shown that the Taylor vortices in the gap between the cylinders qualitatively change the distribution of static pressure and shear stress in the region of vortices connection. It was shown that an increase in the rotation frequency leads to an increase of the unevenness in distribution of the above mentioned functions. The obtained shear stress and static pressure dependence on the rotational frequency make it possible to choose the operating mode of the reactor depending on the provided requirements. It was shown that in the range of rotation frequencies chosen in this work (0.083 < f < 0.233 Hz), the shear stress does not exceed the known literature data (0.002 - 0.1 Pa).

Shear-Flow Instability Saturation by Stable Modes: Hydrodynamics and Gyrokinetics

NASA Astrophysics Data System (ADS)

Fraser, Adrian; Pueschel, M. J.; Terry, P. W.; Zweibel, E. G.

2017-10-01

We present simulations of shear-driven instabilities, focusing on the impact of nonlinearly excited, large-scale, linearly stable modes on the nonlinear cascade, momentum transport, and secondary instabilities. Stable modes, which have previously been shown to significantly affect instability saturation [Fraser et al. PoP 2017], are investigated in a collisionless, gyrokinetic, periodic zonal flow using the Gene code by projecting the results of nonlinear simulations onto a basis of linear eigenmodes that includes both stable and unstable modes. Benchmarking growth rates against previous gyrokinetic studies and an equivalent fluid system demonstrates comparable linear dynamics in the fluid and gyrokinetic systems. Cases of driven and decaying shear-flow turbulence are compared in Gene by using a Krook operator as an effective forcing. For comparison with existing hydrodynamic and MHD shear-flow instability studies, we present results for the shear layer obtained by similar means with the code Dedalus. Supported by U.S. DOE Grant No. DE-FG02-89ER53291, the NSF, and UW-Madison.

A new parallel plate shear cell for in situ real-space measurements of complex fluids under shear flow.

PubMed

Wu, Yu Ling; Brand, Joost H J; van Gemert, Josephus L A; Verkerk, Jaap; Wisman, Hans; van Blaaderen, Alfons; Imhof, Arnout

2007-10-01

We developed and tested a parallel plate shear cell that can be mounted on top of an inverted microscope to perform confocal real-space measurements on complex fluids under shear. To follow structural changes in time, a plane of zero velocity is created by letting the plates move in opposite directions. The location of this plane is varied by changing the relative velocities of the plates. The gap width is variable between 20 and 200 microm with parallelism better than 1 microm. Such a small gap width enables us to examine the total sample thickness using high numerical aperture objective lenses. The achieved shear rates cover the range of 0.02-10(3) s(-1). This shear cell can apply an oscillatory shear with adjustable amplitude and frequency. The maximum travel of each plate equals 1 cm, so that strains up to 500 can be applied. For most complex fluids, an oscillatory shear with such a large amplitude can be regarded as a continuous shear. We measured the flow profile of a suspension of silica colloids in this shear cell. It was linear except for a small deviation caused by sedimentation. To demonstrate the excellent performance and capabilities of this new setup we examined shear induced crystallization and melting of concentrated suspensions of 1 microm diameter silica colloids.

Unsteady Sisko magneto-nanofluid flow with heat absorption and temperature dependent thermal conductivity: A 3D numerical study

NASA Astrophysics Data System (ADS)

Khan, Masood; Ahmad, Latif; Gulzar, M. Mudassar

2018-03-01

The impact of temperature dependent thermal conductivity and convective surface conditions on unsteady 3D Sisko nanofluid flow over a stretching surface is studied in the presence of heat generation/absorption and magnetic field. The numerical solution of nonlinear coupled equations has been carried out to explore the properties of different physical profiles of the fluid flow with varying of parameters. Specifically, the application of generalized Biot numbers and heat generation/absorption parameter in the sketching of temperature and concentration profiles are explored. The effect of all three parameters is noticed in the increasing order for shear thinning (0 < n < 1) and for shear thickening (n > 1) fluids. Moreover, the influence of Biot number γ1 on heat and mass transfer rates, are found in the enhancement and diminishing conducts respectively, in both cases of shear thinning as well as shear thickening fluids and a reverse trend is observed with the variation of Biot number γ2 . Additionally, the present results are validated through skin friction, heat and mass transfer rate values with the comparable values in the existing previous values.

Fundamental Processes of Atomization in Fluid-Fluid Flows

NASA Technical Reports Server (NTRS)

McCready, M. J.; Chang, H.-C.; Leighton, D. T.

2001-01-01

This report outlines the major results of the grant "Fundamental Processes of Atomization in Fluid-Fluid Flows." These include: 1) the demonstration that atomization in liquid/liquid shear flow is driven by a viscous shear instability that triggers the formation of a long thin sheet; 2) discovery of a new mode of interfacial instability for oscillatory two-layer systems whereby a mode that originates within the less viscous liquid phase causes interfacial deformation as the oscillation proceeds; 3) the demonstration that rivulet formation from gravity front occurs because the local front shape specified by gravity and surface tension changes from a nose to a wedge geometry, thus triggering a large increase in viscous resistance; and 4) extension of the studies on nonlinear wave evolution on falling films and in stratified flow, particularly the evolution towards large-amplitude solitary waves that tend to generate drops.

Suppression of thermally excited capillary waves by shear flow.

PubMed

Derks, Didi; Aarts, Dirk G A L; Bonn, Daniel; Lekkerkerker, Henk N W; Imhof, Arnout

2006-07-21

We investigate the thermal fluctuations of the colloidal gas-liquid interface subjected to a shear flow parallel to the interface. Strikingly, we find that the shear strongly suppresses capillary waves, making the interface smoother. This phenomenon can be described by introducing an effective interfacial tension that increases with the shear rate. The increase of sigma(eff) is a direct consequence of the loss of interfacial entropy caused by the flow, which affects especially the slow fluctuations. This demonstrates that the interfacial tension of fluids results from an intrinsic as well as a fluctuation contribution.

A Two-Axis Direct Fluid Shear Stress Sensor

NASA Technical Reports Server (NTRS)

Adcock, Edward E.; Scott, Michael A.; Bajikar, Sateesh S.

2010-01-01

This innovation is a miniature or micro sized semiconductor sensor design that provides two axis direct non-intrusive measurement of skin friction or wall shear stress in fluid flow. The sensor is fabricated by micro-electro-mechanical system (MEMS) technology, enabling small size and low cost reproductions. The sensors have been fabricated by utilizing MEMS fabrication processes to bond a sensing element wafer to a fluid coupling wafer. This layering technique provides for an out of plane dimension that is on the same order of length as the inplane dimensions. The sensor design has the following characteristics: a shear force collecting plate with dimensions that can be tailored to various application specific requirements such as spatial resolution, temporal resolution and shear force range and resolution. This plate is located coplanar to both the sensor body and flow boundary, and is connected to a dual axis gimbal structure by a connecting column or lever arm. The dual axis gimbal structure has torsional hinges with embedded piezoresistive torsional strain gauges which provide a voltage output that is correlated to the applied shear stress (and excitation current) on force collection plate that is located on the flow boundary surface (hence the transduction method). This combination of design elements create a force concentration and resolution structure that enables the generation of a large stress on the strain gauge from the small shear stress on the flow boundary wall. This design as well as the use of back side electrical contacts establishes a non-intrusive method to quantitatively measure the shear force vector on aerodynamic bodies.

Experimental investigation of flow and slip transition in nanochannels

NASA Astrophysics Data System (ADS)

Li, Zhigang; Li, Long; Mo, Jingwen

2014-11-01

Flow slip in nanochannels is sought in many applications, such as sea water desalination and molecular separation, because it can enhance fluid transport, which is essential in nanofluidic systems. Previous findings about the slip length for simple fluids at the nanoscale appear to be controversial. Some experiments and simulations showed that the slip length is independent of shear rate, which agrees with the prediction of classic slip theories. However, there is increasing work showing that slip length is shear rate dependent. In this work, we experimentally investigate the Poiseuille flows in nanochannels. It is found that the flow rate undergoes a transition between two linear regimes as the shear rate is varied. The transition indicates that the non-slip boundary condition is valid at low shear rate. When the shear rate is larger than a critical value, slip takes place and the slip length increases linearly with increasing shear rate before approaching a constant value. The results reported in this work can help advance the understanding of flow slip in nanochannels. This work was supported by the Research Grants Council of the Hong Kong Special Administrative Region under Grant Nos. 615710 and 615312. J. Mo was partially supported by the Postgraduate Scholarship through the Energy Program at HKUST.

Observation of Droplet Size Oscillations in a Two Phase Fluid under Shear Flow

NASA Astrophysics Data System (ADS)

Courbin, Laurent; Panizza, Pascal

2004-11-01

It is well known that complex fluids exhibit strong couplings between their microstructure and the flow field. Such couplings may lead to unusual non linear rheological behavior. Because energy is constantly brought to the system, richer dynamic behavior such as non linear oscillatory or chaotic response is expected. We report on the observation of droplet size oscillations at fixed shear rate. At low shear rates, we observe two steady states for which the droplet size results from a balance between capillary and viscous stress. For intermediate shear rates, the droplet size becomes a periodic function of time. We propose a phenomenological model to account for the observed phenomenon and compare numerical results to experimental data.

Flagellated bacteria trace out a parabolic arc under low shear condition

NASA Astrophysics Data System (ADS)

Ahn, Yongtae; Hashmi, Sara; Walker, Sharon; Hill, Jane

2010-03-01

The measurement and prediction of bacterial transport of bacteria in aquatic systems is of fundamental importance to a variety of fields such as groundwater bioremediation ascending urinary tract infection. The motility of pathogenic bacteria is, however, often missing when considering pathogen translocation prediction. Previously, we reported that flagellated E. coli can translate upstream under low shear flow conditions (Hill et al., 2007). The upstream swimming of flagellated microorganisms depends on hydrodynamic interaction between cell body and surrounding fluid flow. In this study, we use a breathable microfluidic device to image swimming E. coli and P. aeruginosa at a glass surface under low shear flow condition. We find the dominant experimental variables that lead to upstream swimming are: fluid shear, bacterium velocity, and bacterium length. We will present data showing that the sum of forces and torques acting on a bacterium lead to them tracing out a parabolic arc as they turn into the flow to swim upstream.

Elastic Instability of Slender Rods in Steady Shear Flow Yields Positive First Normal Stress Differences

NASA Astrophysics Data System (ADS)

Becker, Leif E.; Shelley, Michael J.

2000-11-01

First normal stress differences in shear flow are a fundamental property of Non-Newtonian fluids. Experiments involving dilute suspensions of slender fibers exhibit a sharp transition to non-zero normal stress differences beyond a critical shear rate, but existing continuum theories for rigid rods predict neither this transition nor the corresponding magnitude of this effect. We present the first conclusive evidence that elastic instabilities are predominantly responsible for observed deviations from the dilute suspension theory of rigid rods. Our analysis is based on slender body theory and the equilibrium equations of elastica. A straight slender body executing its Jeffery orbit in Couette flow is subject to axial fluid forcing, alternating between compression and tension. We present a stability analysis showing that elastic instabilities are possible for strong flows. Simulations give the fully non-linear evolution of this shape instability, and show that flexibility of the fibers alone is sufficient to cause both shear-thinning and significant first normal stress differences.

Enhancement of human mesenchymal stem cell infiltration into the electrospun poly(lactic-co-glycolic acid) scaffold by fluid shear stress.

PubMed

Kim, Min Sung; Lee, Mi Hee; Kwon, Byeong-Ju; Koo, Min-Ah; Seon, Gyeung Mi; Park, Jong-Chul

The infiltration of the cells into the scaffolds is important phenomenon to give them good biocompatibility and even biodegradability. Fluid shear stress is one of the candidates for the infiltration of cells into scaffolds. Here we investigated the directional migration of human mesenchymal stem cells and infiltration into PLGA scaffold by fluid shear stress. The human mesenchymal stem cells showed directional migrations following the direction of the flow (8, 16 dyne/cm(2)). In the scaffold models, the fluid shear stress (8 dyne/cm(2)) enhanced the infiltration of cells but did not influence on the infiltration of Poly(lactic-co-glycolic acid) particles. Copyright © 2015 Elsevier Inc. All rights reserved.

A simplified model to evaluate the effect of fluid rheology on non-Newtonian flow in variable aperture fractures

NASA Astrophysics Data System (ADS)

Felisa, Giada; Ciriello, Valentina; Longo, Sandro; Di Federico, Vittorio

2017-04-01

Modeling of non-Newtonian flow in fractured media is essential in hydraulic fracturing operations, largely used for optimal exploitation of oil, gas and thermal reservoirs. Complex fluids interact with pre-existing rock fractures also during drilling operations, enhanced oil recovery, environmental remediation, and other natural phenomena such as magma and sand intrusions, and mud volcanoes. A first step in the modeling effort is a detailed understanding of flow in a single fracture, as the fracture aperture is typically spatially variable. A large bibliography exists on Newtonian flow in single, variable aperture fractures. Ultimately, stochastic modeling of aperture variability at the single fracture scale leads to determination of the flowrate under a given pressure gradient as a function of the parameters describing the variability of the aperture field and the fluid rheological behaviour. From the flowrate, a flow, or 'hydraulic', aperture can then be derived. The equivalent flow aperture for non-Newtonian fluids of power-law nature in single, variable aperture fractures has been obtained in the past both for deterministic and stochastic variations. Detailed numerical modeling of power-law fluid flow in a variable aperture fracture demonstrated that pronounced channelization effects are associated to a nonlinear fluid rheology. The availability of an equivalent flow aperture as a function of the parameters describing the fluid rheology and the aperture variability is enticing, as it allows taking their interaction into account when modeling flow in fracture networks at a larger scale. A relevant issue in non-Newtonian fracture flow is the rheological nature of the fluid. The constitutive model routinely used for hydro-fracturing modeling is the simple, two-parameter power-law. Yet this model does not characterize real fluids at low and high shear rates, as it implies, for shear-thinning fluids, an apparent viscosity which becomes unbounded for zero shear rate and tends to zero for infinite shear rate. On the contrary, the four-parameter Carreau constitutive equation includes asymptotic values of the apparent viscosity at those limits; in turn, the Carreau rheological equation is well approximated by the more tractable truncated power-law model. Results for flow of such fluids between parallel walls are already available. This study extends the adoption of the truncated power-law model to variable aperture fractures, with the aim of understanding the joint influence of rheology and aperture spatial variability. The aperture variation, modeled within a stochastic or deterministic framework, is taken to be one-dimensional and perpendicular to the flow direction; for stochastic modeling, the influence of different distribution functions is examined. Results are then compared with those obtained for pure power-law fluids for different combinations of model parameters. It is seen that the adoption of the pure power law model leads to significant overestimation of the flowrate with respect to the truncated model, more so for large external pressure gradient and/or aperture variability.

Instabilities in wormlike micelle systems. From shear-banding to elastic turbulence.

PubMed

Fardin, M-A; Lerouge, S

2012-09-01

Shear-banding is ubiquitous in complex fluids. It is related to the organization of the flow into macroscopic bands bearing different viscosities and local shear rates and stacked along the velocity gradient direction. This flow-induced transition towards a heterogeneous flow state has been reported in a variety of systems, including wormlike micellar solutions, telechelic polymers, emulsions, clay suspensions, colloidal gels, star polymers, granular materials, or foams. In the past twenty years, shear-banding flows have been probed by various techniques, such as rheometry, velocimetry and flow birefringence. In wormlike micelle solutions, many of the data collected exhibit unexplained spatio-temporal fluctuations. Different candidates have been identified, the main ones being wall slip, interfacial instability between bands or bulk instability of one of the bands. In this review, we present experimental evidence for a purely elastic instability of the high shear rate band as the main origin for fluctuating shear-banding flows.

Observations of subsonic and supersonic shear flows in laser driven high-energy-density plasmas

NASA Astrophysics Data System (ADS)

Harding, E. C.

2009-11-01

Shear layers containing strong velocity gradients appear in many high-energy-density (HED) systems and play important roles in mixing and the transition to turbulence. Yet few laboratory experiments have been carried out to study their detailed evolution in this extreme environment where plasmas are compressible, actively ionizing, often involve strong shock waves and have complex material properties. Many shear flows produce the Kelvin-Helmholtz (KH) instability, which initiates the mixing at a fluid interface. We present results from two dedicated shear flow experiments that produced overall subsonic and supersonic flows using novel target designs. In the subsonic case, the Omega laser was used to drive a blast wave along a rippled interface between plastic and foam, shocking both the materials to produce two fluids separated by a sharp shear layer. The interface subsequently rolled-upped into large KH vortices that were accompanied by bubble-like structures of unknown origin. This was the first time the evolution of a well-resolved KH instability was observed in a HED plasma in the laboratory. We have analyzed the properties and dynamics of the plasma based on the data and fundamental models, without resorting to simulated values. In the second, supersonic experiment the Nike laser was used to drive a supersonic flow of Al plasma along a rippled, low-density foam surface. Here again the flowing plasma drove a shock into the second material, so that two fluids were separated by a shear layer. In contrast to the subsonic case, the flow developed shocks around the ripples in response to the supersonic flow of Al. Collaborators: R.P. Drake, O.A. Hurricane, J.F. Hansen, Y. Aglitskiy, T. Plewa, B.A. Remington, H.F. Robey, J.L. Weaver, A.L. Velikovich, R.S. Gillespie, M.J. Bono, M.J. Grosskopf, C.C. Kuranz, A. Visco.

Shear-Induced Amyloid Formation in the Brain: I. Potential Vascular and Parenchymal Processes.

PubMed

Trumbore, Conrad N

2016-09-06

Shear distortion of amyloid-beta (Aβ) solutions accelerates amyloid cascade reactions that may yield different toxic oligomers than those formed in quiescent solutions. Recent experiments indicate that cerebrospinal fluid (CSF) and interstitial fluid (ISF) containing Aβ flow through narrow brain perivascular pathways and brain parenchyma. This paper suggests that such flow causes shear distortion of Aβ molecules involving conformation changes that may be one of the initiating events in the etiology of Alzheimer's disease. Aβ shearing can occur in or around brain arteries and arterioles and is suggested as the origin of cerebral amyloid angiopathy deposits in cerebrovascular walls. Comparatively low flow rates of ISF within the narrow extracellular spaces (ECS) of the brain parenchyma are suggested as a possible initiating factor in both the formation of neurotoxic Aβ42 oligomers and amyloid fibrils. Aβ42 in slow-flowing ISF can gain significant shear energy at or near the walls of tortuous brain ECS flow paths, promoting the formation of a shear-distorted, excited state hydrophobic Aβ42* conformation. This Aβ42* molecule could possibly be involved in one of two paths, one involving rapid adsorption to a brain membrane surface, ultimately forming neurotoxic oligomers on membranes, and the other ultimately forming plaque within the ECS flow pathways. Rising Aβ concentrations combined with shear at or near critical brain membranes are proposed as contributing factors to Alzheimer's disease neurotoxicity. These hypotheses may be applicable in other neurodegenerative diseases, including tauopathies and alpha-synucleinopathies, in which shear-distorted proteins also may form in the brain ECS.

A novel investigation of a micropolar fluid characterized by nonlinear constitutive diffusion model in boundary layer flow and heat transfer.

PubMed

Sui, Jize; Zhao, Peng; Cheng, Zhengdong; Zheng, Liancun; Zhang, Xinxin

2017-02-01

The rheological and heat-conduction constitutive models of micropolar fluids (MFs), which are important non-Newtonian fluids, have been, until now, characterized by simple linear expressions, and as a consequence, the non-Newtonian performance of such fluids could not be effectively captured. Here, we establish the novel nonlinear constitutive models of a micropolar fluid and apply them to boundary layer flow and heat transfer problems. The nonlinear power law function of angular velocity is represented in the new models by employing generalized " n -diffusion theory," which has successfully described the characteristics of non-Newtonian fluids, such as shear-thinning and shear-thickening fluids. These novel models may offer a new approach to the theoretical understanding of shear-thinning behavior and anomalous heat transfer caused by the collective micro-rotation effects in a MF with shear flow according to recent experiments. The nonlinear similarity equations with a power law form are derived and the approximate analytical solutions are obtained by the homotopy analysis method, which is in good agreement with the numerical solutions. The results indicate that non-Newtonian behaviors involving a MF depend substantially on the power exponent n and the modified material parameter [Formula: see text] introduced by us. Furthermore, the relations of the engineering interest parameters, including local boundary layer thickness, local skin friction, and Nusselt number are found to be fitted by a quadratic polynomial to n with high precision, which enables the extraction of the rapid predictions from a complex nonlinear boundary-layer transport system.

A novel investigation of a micropolar fluid characterized by nonlinear constitutive diffusion model in boundary layer flow and heat transfer

PubMed Central

Zhao, Peng; Cheng, Zhengdong; Zheng, Liancun; Zhang, Xinxin

2017-01-01

The rheological and heat-conduction constitutive models of micropolar fluids (MFs), which are important non-Newtonian fluids, have been, until now, characterized by simple linear expressions, and as a consequence, the non-Newtonian performance of such fluids could not be effectively captured. Here, we establish the novel nonlinear constitutive models of a micropolar fluid and apply them to boundary layer flow and heat transfer problems. The nonlinear power law function of angular velocity is represented in the new models by employing generalized “n-diffusion theory,” which has successfully described the characteristics of non-Newtonian fluids, such as shear-thinning and shear-thickening fluids. These novel models may offer a new approach to the theoretical understanding of shear-thinning behavior and anomalous heat transfer caused by the collective micro-rotation effects in a MF with shear flow according to recent experiments. The nonlinear similarity equations with a power law form are derived and the approximate analytical solutions are obtained by the homotopy analysis method, which is in good agreement with the numerical solutions. The results indicate that non-Newtonian behaviors involving a MF depend substantially on the power exponent n and the modified material parameter K0 introduced by us. Furthermore, the relations of the engineering interest parameters, including local boundary layer thickness, local skin friction, and Nusselt number are found to be fitted by a quadratic polynomial to n with high precision, which enables the extraction of the rapid predictions from a complex nonlinear boundary-layer transport system. PMID:28344433

Influence of Normal and Shear Stress on the Hydraulic Transmissivity of Thin Cracks in a Tight Quartz Sandstone, a Granite, and a Shale

NASA Astrophysics Data System (ADS)

Rutter, Ernest H.; Mecklenburgh, Julian

2018-02-01

Transmissivity of fluids along fractures in rocks is reduced by increasing normal stress acting across them, demonstrated here through gas flow experiments on Bowland shale, and oil flow experiments on Pennant sandstone and Westerly granite. Additionally, the effect of imposing shear stress at constant normal stress was determined, until frictional sliding started. In all cases, increasing shear stress causes an accelerating reduction of transmissivity by 1 to 3 orders of magnitude as slip initiated, as a result of the formation of wear products that block fluid pathways. Only in the case of granite, and to a lesser extent in the sandstone, was there a minor amount of initial increase of transmissivity prior to the onset of slip. These results cast into doubt the commonly applied presumption that cracks with high resolved shear stresses are the most conductive. In the shale, crack transmissivity is commensurate with matrix permeability, such that shales are expected always to be good seals. For the sandstone and granite, unsheared crack transmissivity was respectively 2 and 2.5 orders of magnitude greater than matrix permeability. For these rocks crack transmissivity can dominate fluid flow in the upper crust, potentially enough to permit maintenance of a hydrostatic fluid pressure gradient in a normal (extensional) faulting regime.

Oscillatory fluid flow in deformable tubes: Implications for pore-scale hydromechanics from comparing experimental observations with theoretical predictions.

PubMed

Kurzeja, Patrick; Steeb, Holger; Strutz, Marc A; Renner, Jörg

2016-12-01

Oscillatory flow of four fluids (air, water, two aqueous sodium-tungstate solutions) was excited at frequencies up to 250 Hz in tubes of two materials (steel, silicone) covering a wide range in length, diameter, and thickness. The hydrodynamical response was characterized by phase shift and amplitude ratio between pressures in an upstream (pressure excitation) and a downstream reservoir connected by the tubes. The resulting standing flow waves reflect viscosity-controlled diffusive behavior and inertia-controlled wave behavior for oscillation frequencies relatively low and high compared to Biot's critical frequency, respectively. Rigid-tube theories correspond well with the experimental results for steel tubes filled with air or water. The wave modes observed for silicone tubes filled with the rather incompressible liquids or air, however, require accounting for the solid's shear and bulk modulus to correctly predict speed of pressure propagation and deformation mode. The shear mode may be responsible for significant macroscopic attenuation in porous materials with effective frame-shear moduli lower than the bulk modulus of the pore fluid. Despite notable effects of the ratio of densities and of acoustic and shear velocity of fluid and solid, Biot's frequency remains an approximate indicator of the transition from the viscosity to the inertia controlled regime.

Surface deformation and shear flow in ligand mediated cell adhesion.

PubMed

Sircar, Sarthok; Roberts, Anthony J

2016-10-01

We present a unified, multiscale model to study the attachment/detachment dynamics of two deforming, charged, near spherical cells, coated with binding ligands and subject to a slow, homogeneous shear flow in a viscous, ionic fluid medium. The binding ligands on the surface of the cells experience both attractive and repulsive forces in an ionic medium and exhibit finite resistance to rotation via bond tilting. The microscale drag forces and couples describing the fluid flow inside the small separation gap between the cells, are calculated using a combination of methods in lubrication theory and previously published numerical results. For a selected range of material and fluid parameters, a hysteretic transition of the sticking probability curves (i.e., the function [Formula: see text]) between the adhesion phase (when [Formula: see text]) and the fragmentation phase (when [Formula: see text]) is attributed to a nonlinear relation between the total nanoscale binding forces and the separation gap between the cells. We show that adhesion is favoured in highly ionic fluids, increased deformability of the cells, elastic binders and a higher fluid shear rate (until a critical threshold value of shear rate is reached). Within a selected range of critical shear rates, the continuation of the limit points (i.e., the turning points where the slope of [Formula: see text] changes sign) predict a bistable region, indicating an abrupt switching between the adhesion and the fragmentation regimes. Although, bistability in the adhesion-fragmentation phase diagram of two deformable, charged cells immersed in an ionic aqueous environment has been identified by some in vitro experiments, but until now, has not been quantified theoretically.

Pulsatile Fluid Shear in Bone Remodeling

NASA Technical Reports Server (NTRS)

Frangos, John A.

1997-01-01

The objective of this investigation was to elucidate the sensitivity to transients in fluid shear stress in bone remodeling. Bone remodeling is clearly a function of the local mechanical environment which includes interstitial fluid flow. Traditionally, load-induced remodeling has been associated with low frequency (1-2 Hz) signals attributed to normal locomotion. McLeod and Rubin, however, demonstrated in vivo remodeling events associated with high frequency (15-30 Hz) loading. Likewise, other in vivo studies demonstrated that slowly applied strains did not trigger remodeling events. We therefore hypothesized that the mechanosensitive pathways which control bone maintenance and remodeling are differentially sensitive to varying rates of applied fluid shear stress.

Characterization of local fluid flow in 3D porous construct characterized by Fourier domain Doppler optical coherence tomography

NASA Astrophysics Data System (ADS)

Bagnaninchi, P. O.; Yang, Y.; El Haj, A.; Hinds, M. T.; Wang, R. K.

2007-02-01

In order to achieve functional tissue with the correct biomechanical properties it is critical to stimulate mechanically the cells. Perfusion bioreactor induces fluid shear stress that has been well characterized for two-dimensional culture where both simulation and experimental data are available. However these results can't be directly translated to tissue engineering that makes use of complex three-dimensional porous scaffold. Moreover, stimulated cells produce extensive extra-cellular matrix (ECM) that alter dramatically the micro-architecture of the constructs, changing the local flow dynamic. In this study a Fourier domain Doppler optical coherent tomography (FD-DOCT) system working at 1300nm with a bandwidth of 50nm has been used to determine the local flow rate inside different types of porous scaffolds used in tissue engineering. Local flow rates can then be linearly related, for Newtonian fluid, to the fluid shear stress occurring on the pores wall. Porous chitosan scaffolds (\\fgr 1.5mm x 3mm) with and without a central 250 μm microchannel have been produced by a freeze-drying technique. This techniques allow us to determine the actual shear stress applied to the cells and to optimise the input flow rate consequently, but also to relate the change of the flow distribution to the amount of ECM production allowing the monitoring of tissue formation.

A design methodology of magentorheological fluid damper using Herschel-Bulkley model

NASA Astrophysics Data System (ADS)

Liao, Linqing; Liao, Changrong; Cao, Jianguo; Fu, L. J.

2003-09-01

Magnetorheological fluid (MR fluid) is highly concentrated suspension of very small magnetic particle in inorganic oil. The essential behavior of MR fluid is its ability to reversibly change from free-flowing, linear viscous liquids to semi-solids having controllable yield strength in milliseconds when exposed to magnetic field. This feature provides simple, quiet, rapid-response interfaces between electronic controls and mechanical systems. In this paper, a mini-bus MR fluid damper based on plate Poiseuille flow mode is typically analyzed using Herschel-Bulkley model, which can be used to account for post-yield shear thinning or thickening under the quasi-steady flow condition. In the light of various value of flow behavior index, the influences of post-yield shear thinning or thickening on flow velocity profiles of MR fluid in annular damping orifice are examined numerically. Analytical damping coefficient predictions also are compared via the nonlinear Bingham plastic model and Herschel-Bulkley constitutive model. A MR fluid damper, which is designed and fabricated according to design method presented in this paper, has tested by electro-hydraulic servo vibrator and its control system in National Center for Test and Supervision of Coach Quality. The experimental results reveal that the analysis methodology and design theory are reasonable and MR fluid damper can be designed according to the design methodology.

Multiscale Particle-Based Modeling of Flowing Platelets in Blood Plasma Using Dissipative Particle Dynamics and Coarse Grained Molecular Dynamics

PubMed Central

Zhang, Peng; Gao, Chao; Zhang, Na; Slepian, Marvin J.; Deng, Yuefan; Bluestein, Danny

2014-01-01

We developed a multiscale particle-based model of platelets, to study the transport dynamics of shear stresses between the surrounding fluid and the platelet membrane. This model facilitates a more accurate prediction of the activation potential of platelets by viscous shear stresses - one of the major mechanisms leading to thrombus formation in cardiovascular diseases and in prosthetic cardiovascular devices. The interface of the model couples coarse-grained molecular dynamics (CGMD) with dissipative particle dynamics (DPD). The CGMD handles individual platelets while the DPD models the macroscopic transport of blood plasma in vessels. A hybrid force field is formulated for establishing a functional interface between the platelet membrane and the surrounding fluid, in which the microstructural changes of platelets may respond to the extracellular viscous shear stresses transferred to them. The interaction between the two systems preserves dynamic properties of the flowing platelets, such as the flipping motion. Using this multiscale particle-based approach, we have further studied the effects of the platelet elastic modulus by comparing the action of the flow-induced shear stresses on rigid and deformable platelet models. The results indicate that neglecting the platelet deformability may overestimate the stress on the platelet membrane, which in turn may lead to erroneous predictions of the platelet activation under viscous shear flow conditions. This particle-based fluid-structure interaction multiscale model offers for the first time a computationally feasible approach for simulating deformable platelets interacting with viscous blood flow, aimed at predicting flow induced platelet activation by using a highly resolved mapping of the stress distribution on the platelet membrane under dynamic flow conditions. PMID:25530818

Microgravity

NASA Image and Video Library

2001-01-24

The Critical Viscosity of Xenon Experiment (CVX-2) on the STS-107 Research 1 mission in 2002 will measure the viscous behavior of xenon, a heavy inert gas used in flash lamps and ion rocket engines, at its critical point. Shear thirning will cause a normally viscous fluid -- such as pie filling or whipped cream -- to deform and flow more readily under high shear conditions. In shear thinning, a pocket of fluid will deform and move one edge forward, as depicted here.

The effects of recirculation flows on mass transfer from the arterial wall to flowing blood.

PubMed

Zhang, Zhiguo; Deng, Xiaoyan; Fan, Yubo; Guidoin, Robert

2008-01-01

Using a sudden tubular expansion as a model of an arterial stenosis, the effect of disturbed flow on mass transfer from the arterial wall to flowing blood was studied theoretically and tested experimentally by measuring the dissolution rate of benzoic acid disks forming the outer tube of a sudden tubular expansion. The study revealed that mass transfer from vessel wall to flowing fluid in regions of disturbed flow is independent of wall shear rates. The rate of mass transfer is significantly higher in regions of disturbed flow with a local maximum around the reattachment point where the wall shear rate is zero. The experimental study also revealed that the rate of mass transfer from the vessel wall to a flowing fluid is much higher in the presence of microspheres (as models of blood cells) in the flowing fluid and under the condition of pulsatile flow than in steady flow. These results imply that flow disturbance may enhance the transport of biochemicals and macromolecules, such as plasma proteins and lipoproteins synthesized within the blood vessel wall, from the blood vessel wall to flowing blood.

Long-wave equivalent viscoelastic solids for porous rocks saturated by two-phase fluids

NASA Astrophysics Data System (ADS)

Santos, J. E.; Savioli, G. B.

2018-04-01

Seismic waves traveling across fluid-saturated poroelastic materials with mesoscopic-scale heterogeneities induce fluid flow and Biot's slow waves generating energy loss and velocity dispersion. Using Biot's equations of motion to model these type of heterogeneities would require extremely fine meshes. We propose a numerical upscaling procedure to determine the complex and frequency dependent P-wave and shear moduli of an effective viscoelastic medium long-wave equivalent to a poroelastic solid saturated by a two-phase fluid. The two-phase fluid is defined in terms of capillary pressure and relative permeability flow functions. The P-wave and shear effective moduli are determined using harmonic compressibility and shear experiments applied on representative samples of the bulk material. Each experiment is associated with a boundary value problem that is solved using the finite element method. Since a poroelastic solid saturated by a two-phase fluid supports the existence of two slow waves, this upscaling procedure allows to analyze their effect on the mesoscopic-loss mechanism in hydrocarbon reservoir formations. Numerical results show that a two-phase Biot medium model predicts higher attenuation than classic Biot models.

Long-wave equivalent viscoelastic solids for porous rocks saturated by two-phase fluids

NASA Astrophysics Data System (ADS)

Santos, J. E.; Savioli, G. B.

2018-07-01

Seismic waves travelling across fluid-saturated poroelastic materials with mesoscopic-scale heterogeneities induce fluid flow and Biot's slow waves generating energy loss and velocity dispersion. Using Biot's equations of motion to model these type of heterogeneities would require extremely fine meshes. We propose a numerical upscaling procedure to determine the complex and frequency-dependent Pwave and shear moduli of an effective viscoelastic medium long-wave equivalent to a poroelastic solid saturated by a two-phase fluid. The two-phase fluid is defined in terms of capillary pressure and relative permeability flow functions. The Pwave and shear effective moduli are determined using harmonic compressibility and shear experiments applied on representative samples of the bulk material. Each experiment is associated with a boundary value problem that is solved using the finite element method. Since a poroelastic solid saturated by a two-phase fluid supports the existence of two slow waves, this upscaling procedure allows to analyse their effect on the mesoscopic loss mechanism in hydrocarbon reservoir formations. Numerical results show that a two-phase Biot medium model predicts higher attenuation than classic Biot models.

Stochastic characteristics and Second Law violations of atomic fluids in Couette flow

NASA Astrophysics Data System (ADS)

Raghavan, Bharath V.; Karimi, Pouyan; Ostoja-Starzewski, Martin

2018-04-01

Using Non-equilibrium Molecular Dynamics (NEMD) simulations, we study the statistical properties of an atomic fluid undergoing planar Couette flow, in which particles interact via a Lennard-Jones potential. We draw a connection between local density contrast and temporal fluctuations in the shear stress, which arise naturally through the equivalence between the dissipation function and entropy production according to the fluctuation theorem. We focus on the shear stress and the spatio-temporal density fluctuations and study the autocorrelations and spectral densities of the shear stress. The bispectral density of the shear stress is used to measure the degree of departure from a Gaussian model and the degree of nonlinearity induced in the system owing to the applied strain rate. More evidence is provided by the probability density function of the shear stress. We use the Information Theory to account for the departure from Gaussian statistics and to develop a more general probability distribution function that captures this broad range of effects. By accounting for negative shear stress increments, we show how this distribution preserves the violations of the Second Law of Thermodynamics observed in planar Couette flow of atomic fluids, and also how it captures the non-Gaussian nature of the system by allowing for non-zero higher moments. We also demonstrate how the temperature affects the band-width of the shear-stress and how the density affects its Power Spectral Density, thus determining the conditions under which the shear-stress acts is a narrow-band or wide-band random process. We show that changes in the statistical characteristics of the parameters of interest occur at a critical strain rate at which an ordering transition occurs in the fluid causing shear thinning and affecting its stability. A critical strain rate of this kind is also predicted by the Loose-Hess stability criterion.

Mechanism of nonlinear flow pattern selection in moderately non-Boussinesq mixed convection.

PubMed

Suslov, Sergey A

2010-02-01

Nonlinear (non-Boussinesq) variations in fluid's density, viscosity, and thermal conductivity caused by a large temperature gradient in a flow domain lead to a wide variety of instability phenomena in mixed convection channel flow of a simple gas such as air. It is known that in strongly nonisothermal flows, the instabilities and the resulting flow patterns are caused by competing buoyancy and shear effects [see S. A. Suslov and S. Paolucci, J. Fluid Mech. 302, 91 (1995)]. However, as is the case in the Boussinesq limit of small temperature gradients, in moderately non-Boussinesq regimes, only a shear instability mechanism is active. Yet in contrast to Boussinesq flows, multiple instability modes are still detected. By reducing the system of full governing Navier-Stokes equations to a dynamical system of coupled Landau-type disturbance amplitude equations we compute a comprehensive parametric map of various shear-driven instabilities observed in a representative moderately non-Boussinesq regime. Subsequently, we analyze nonlinear interaction of unstable modes and reveal physical reasons for their appearance.

Modeling of thermodynamic non-equilibrium flows around cylinders and in channels

NASA Astrophysics Data System (ADS)

Sinha, Avick; Gopalakrishnan, Shiva

2017-11-01

Numerical simulations for two different types of flash-boiling flows, namely shear flow (flow through a de-Laval nozzle) and free shear flow (flow past a cylinder) are carried out in the present study. The Homogenous Relaxation Model (HRM) is used to model the thermodynamic non-equilibrium process. It was observed that the vaporization of the fluid stream, which was initially maintained at a sub-cooled state, originates at the nozzle throat. This is because the fluid accelerates at the vena-contracta and subsequently the pressure falls below the saturation vapor pressure, generating a two-phase mixture in the diverging section of the nozzle. The mass flow rate at the nozzle was found to decrease with the increase in fluid inlet temperature. A similar phenomenon also occurs for the free shear case due to boundary layer separation, causing a drop in pressure behind the cylinder. The mass fraction of vapor is maximum at rear end of the cylinder, where the size of the wake is highest. As the back pressure is reduced, severe flashing behavior was observed. The numerical simulations were validated against available experimental data. The authors gratefully acknowledge funding from the public-private partnership between DST, Confederation of Indian Industry and General Electric Pvt. Ltd.

A Multi-Phase Based Fluid-Structure-Microfluidic interaction sensor for Aerodynamic Shear Stress

NASA Astrophysics Data System (ADS)

Hughes, Christopher; Dutta, Diganta; Bashirzadeh, Yashar; Ahmed, Kareem; Qian, Shizhi

2014-11-01

A novel innovative microfluidic shear stress sensor is developed for measuring shear stress through multi-phase fluid-structure-microfluidic interaction. The device is composed of a microfluidic cavity filled with an electrolyte liquid. Inside the cavity, two electrodes make electrochemical velocimetry measurements of the induced convection. The cavity is sealed with a flexible superhydrophobic membrane. The membrane will dynamically stretch and flex as a result of direct shear cross-flow interaction with the seal structure, forming instability wave modes and inducing fluid motion within the microfluidic cavity. The shear stress on the membrane is measured by sensing the induced convection generated by membrane deflections. The advantages of the sensor over current MEMS based shear stress sensor technology are: a simplified design with no moving parts, optimum relationship between size and sensitivity, no gaps such as those created by micromachining sensors in MEMS processes. We present the findings of a feasibility study of the proposed sensor including wind-tunnel tests, microPIV measurements, electrochemical velocimetry, and simulation data results. The study investigates the sensor in the supersonic and subsonic flow regimes. Supported by a NASA SBIR phase 1 contract.

Radiating gravitational collapse with shear viscosity

NASA Astrophysics Data System (ADS)

Chan, R.

2000-08-01

A model is proposed of a collapsing radiating star consisting of an isotropic fluid with shear viscosity undergoing radial heat flow with outgoing radiation. The pressure of the star, at the beginning of the collapse, is isotropic but owing to the presence of the shear viscosity the pressure becomes more and more anisotropic. The behaviour of the density, pressure, mass, luminosity and the effective adiabatic index is analysed. Our work is compared to the case of a collapsing shearing fluid of a previous model, for a star with 6Msolar.

A dilation-driven vortex flow in sheared granular materials explains a rheometric anomaly.

PubMed

Krishnaraj, K P; Nott, Prabhu R

2016-02-11

Granular flows occur widely in nature and industry, yet a continuum description that captures their important features is yet not at hand. Recent experiments on granular materials sheared in a cylindrical Couette device revealed a puzzling anomaly, wherein all components of the stress rise nearly exponentially with depth. Here we show, using particle dynamics simulations and imaging experiments, that the stress anomaly arises from a remarkable vortex flow. For the entire range of fill heights explored, we observe a single toroidal vortex that spans the entire Couette cell and whose sense is opposite to the uppermost Taylor vortex in a fluid. We show that the vortex is driven by a combination of shear-induced dilation, a phenomenon that has no analogue in fluids, and gravity flow. Dilatancy is an important feature of granular mechanics, but not adequately incorporated in existing models.

Viscoinertial regime of immersed granular flows

NASA Astrophysics Data System (ADS)

Amarsid, L.; Delenne, J.-Y.; Mutabaruka, P.; Monerie, Y.; Perales, F.; Radjai, F.

2017-07-01

By means of extensive coupled molecular dynamics-lattice Boltzmann simulations, accounting for grain dynamics and subparticle resolution of the fluid phase, we analyze steady inertial granular flows sheared by a viscous fluid. We show that, for a broad range of system parameters (shear rate, confining stress, fluid viscosity, and relative fluid-grain density), the frictional strength and packing fraction can be described by a modified inertial number incorporating the fluid effect. In a dual viscous description, the effective viscosity diverges as the inverse square of the difference between the packing fraction and its jamming value, as observed in experiments. We also find that the fabric and force anisotropies extracted from the contact network are well described by the modified inertial number, thus providing clear evidence for the role of these key structural parameters in dense suspensions.

Diffusion in shear flow

NASA Astrophysics Data System (ADS)

Dufty, J. W.

1984-09-01

Diffusion of a tagged particle in a fluid with uniform shear flow is described. The continuity equation for the probability density describing the position of the tagged particle is considered. The diffusion tensor is identified by expanding the irreversible part of the probability current to first order in the gradient of the probability density, but with no restriction on the shear rate. The tensor is expressed as the time integral of a nonequilibrium autocorrelation function for the velocity of the tagged particle in its local fluid rest frame, generalizing the Green-Kubo expression to the nonequilibrium state. The tensor is evaluated from results obtained previously for the velocity autocorrelation function that are exact for Maxwell molecules in the Boltzmann limit. The effects of viscous heating are included and the dependence on frequency and shear rate is displayed explicitly. The mode-coupling contributions to the frequency and shear-rate dependent diffusion tensor are calculated.

Flow curve analysis of a Pickering emulsion-polymerized PEDOT:PSS/PS-based electrorheological fluid

NASA Astrophysics Data System (ADS)

Kim, So Hee; Choi, Hyoung Jin; Leong, Yee-Kwong

2017-11-01

The steady shear electrorheological (ER) response of poly(3, 4-ethylenedioxythiophene): poly(styrene sulfonate)/polystyrene (PEDOT:PSS/PS) composite particles, which were initially fabricated from Pickering emulsion polymerization, was tested with a 10 vol% ER fluid dispersed in a silicone oil. The model independent shear rate and yield stress obtained from the raw torque-rotational speed data using a Couette type rotational rheometer under an applied electric field strength were then analyzed by Tikhonov regularization, which is the most suitable technique for solving an ill-posed inverse problem. The shear stress-shear rate data also fitted well with the data extracted from the Bingham fluid model.

An adaptive extended finite element method for the analysis of agglomeration of colloidal particles in a flowing fluid

DOE Office of Scientific and Technical Information (OSTI.GOV)

Choi, Young Joon; Jorshari, Razzi Movassaghi; Djilali, Ned

2015-03-10

Direct numerical simulations of the flow-nanoparticle interaction in a colloidal suspension are presented using an extended finite element method (XFEM) in which the dynamics of the nanoparticles is solved in a fully-coupled manner with the flow. The method is capable of accurately describing solid-fluid interfaces without the need of boundary-fitted meshes to investigate the dynamics of particles in complex flows. In order to accurately compute the high interparticle shear stresses and pressures while minimizing computing costs, an adaptive meshing technique is incorporated with the fluid-structure interaction algorithm. The particle-particle interaction at the microscopic level is modeled using the Lennard-Jones (LJ)more » potential and the corresponding potential parameters are determined by a scaling procedure. The study is relevant to the preparation of inks used in the fabrication of catalyst layers for fuel cells. In this paper, we are particularly interested in investigating agglomeration of the nanoparticles under external shear flow in a sliding bi-periodic Lees-Edwards frame. The results indicate that the external shear has a crucial impact on the structure formation of colloidal particles in a suspension.« less

Multiscale modeling and simulation for polymer melt flows between parallel plates

NASA Astrophysics Data System (ADS)

Yasuda, Shugo; Yamamoto, Ryoichi

2010-03-01

The flow behaviors of polymer melt composed of short chains with ten beads between parallel plates are simulated by using a hybrid method of molecular dynamics and computational fluid dynamics. Three problems are solved: creep motion under a constant shear stress and its recovery motion after removing the stress, pressure-driven flows, and the flows in rapidly oscillating plates. In the creep/recovery problem, the delayed elastic deformation in the creep motion and evident elastic behavior in the recovery motion are demonstrated. The velocity profiles of the melt in pressure-driven flows are quite different from those of Newtonian fluid due to shear thinning. Velocity gradients of the melt become steeper near the plates and flatter at the middle between the plates as the pressure gradient increases and the temperature decreases. In the rapidly oscillating plates, the viscous boundary layer of the melt is much thinner than that of Newtonian fluid due to the shear thinning of the melt. Three different rheological regimes, i.e., the viscous fluid, viscoelastic liquid, and viscoelastic solid regimes, form over the oscillating plate according to the local Deborah numbers. The melt behaves as a viscous fluid in a region for ωτR≲1 , and the crossover between the liquidlike and solidlike regime takes place around ωτα≃1 (where ω is the angular frequency of the plate and τR and τα are Rouse and α relaxation time, respectively).

Multiscale modeling and simulation for polymer melt flows between parallel plates.

PubMed

Yasuda, Shugo; Yamamoto, Ryoichi

2010-03-01

The flow behaviors of polymer melt composed of short chains with ten beads between parallel plates are simulated by using a hybrid method of molecular dynamics and computational fluid dynamics. Three problems are solved: creep motion under a constant shear stress and its recovery motion after removing the stress, pressure-driven flows, and the flows in rapidly oscillating plates. In the creep/recovery problem, the delayed elastic deformation in the creep motion and evident elastic behavior in the recovery motion are demonstrated. The velocity profiles of the melt in pressure-driven flows are quite different from those of Newtonian fluid due to shear thinning. Velocity gradients of the melt become steeper near the plates and flatter at the middle between the plates as the pressure gradient increases and the temperature decreases. In the rapidly oscillating plates, the viscous boundary layer of the melt is much thinner than that of Newtonian fluid due to the shear thinning of the melt. Three different rheological regimes, i.e., the viscous fluid, viscoelastic liquid, and viscoelastic solid regimes, form over the oscillating plate according to the local Deborah numbers. The melt behaves as a viscous fluid in a region for omegatauR < approximately 1 , and the crossover between the liquidlike and solidlike regime takes place around omegataualpha approximately equal 1 (where omega is the angular frequency of the plate and tauR and taualpha are Rouse and alpha relaxation time, respectively).

Fluid dynamic effects on staphylococci bacteria biofilms

NASA Astrophysics Data System (ADS)

Sherman, Erica; Bayles, Kenneth; Endres, Jennifer; Wei, Timothy

2016-11-01

Staphylococcus aureus bacteria are able to form biofilms and distinctive tower structures that facilitate their ability to tolerate treatment and to spread within the human body. The formation of towers, which break off, get carried downstream and serve to initiate biofilms in other parts of the body are of particular interest here. It is known that flow conditions play a role in the development, dispersion and propagation of biofilms in general. The influence of flow on tower formation, however, is not at all understood. This work is focused on the effect of applied shear on tower development. The hypothesis being examined is that tower structures form within a specific range of shear stresses and that there is an as yet ill defined fluid dynamic phenomenon that occurs hours before a tower forms. In this study, a range of shear stresses is examined that brackets 0.6 dynes/cm2, the nominal shear stress where towers seem most likely to form. This talk will include µPTV measurements and cell density data indicating variations in flow and biofilm evolution as a function of the applied shear. Causal relations between flow and biofilm development will be discussed.

Mechanisms of Mechano-Transduction within Osteoblasts

DTIC Science & Technology

1999-09-01

inositol trisphosphate levels (Reich and Frangos , 1993) with increasing shear stress. In a study concerning the effect of fluid shear...stress on cultured rat calvaria 34 osteoblasts, Hillsley and Frangos (1997) reported no change in collagen or osteopontin expression...Hillsley MV and Frangos JA (1997). Alkaline phosphatase in osteoblasts is down-regulated by pulsatile fluid flow. Calcif Tissue Int 60

Critical Viscosity of Xenon

NASA Technical Reports Server (NTRS)

2001-01-01

The Critical Viscosity of Xenon Experiment (CVX-2) on the STS-107 Research 1 mission in 2002 will measure the viscous behavior of xenon, a heavy inert gas used in flash lamps and ion rocket engines, at its critical point. Shear thirning will cause a normally viscous fluid -- such as pie filling or whipped cream -- to deform and flow more readily under high shear conditions. In shear thinning, a pocket of fluid will deform and move one edge forward, as depicted here.

Particle acceleration in step function shear flows - A microscopic analysis

NASA Technical Reports Server (NTRS)

Jokipii, J. R.; Morfill, G. E.

1990-01-01

The transport of energetic particles in a moving, scattering fluid, which has a large shear in its velocity over a distance small compared with the scattering mean free path is discussed. The analysis is complementary to an earlier paper by Earl, Jokipii, and Morfill (1988), which considered effects of more-gradual shear in the diffusion approximation. The case in which the scattering fluid undergoes a step function change in velocity, in the direction normal to the flow is considered. An analytical, approximate calculation and a Monte Carlo analysis of particle motion are presented. It is found that particles gain energy at a rate proportional to the square of the magnitude of the velocity change.

Sensor for Boundary Shear Stress in Fluid Flow

NASA Technical Reports Server (NTRS)

Bao, Xiaoqi; Badescu, Mircea; Sherrit, Stewart; Bar-Cohen, Yoseph; Lih, Shyh-Shiuh; Chang, Zensheu; Trease, Brian P.; Kerenyi, Kornel; Widholm, Scott E.; Ostlund, Patrick N.

2012-01-01

The formation of scour patterns at bridge piers is driven by the forces at the boundary of the water flow. In most experimental scour studies, indirect processes have been applied to estimate the shear stress using measured velocity profiles. The estimations are based on theoretical models and associated assumptions. However, the turbulence flow fields and boundary layer in the pier-scour region are very complex and lead to low-fidelity results. In addition, available turbulence models cannot account accurately for the bed roughness effect. Direct measurement of the boundary shear stress, normal stress, and their fluctuations are attractive alternatives. However, most direct-measurement shear sensors are bulky in size or not compatible to fluid flow. A sensor has been developed that consists of a floating plate with folded beam support and an optical grid on the back, combined with a high-resolution optical position probe. The folded beam support makes the floating plate more flexible in the sensing direction within a small footprint, while maintaining high stiffness in the other directions. The floating plate converts the shear force to displacement, and the optical probe detects the plate s position with nanometer resolution by sensing the pattern of the diffraction field of the grid through a glass window. This configuration makes the sensor compatible with liquid flow applications.

Two-Axis Direct Fluid Shear Stress Sensor for Aerodynamic Applications

NASA Technical Reports Server (NTRS)

Bajikar, Sateesh S.; Scott, Michael A.; Adcock, Edward E.

2011-01-01

This miniature or micro-sized semiconductor sensor design provides direct, nonintrusive measurement of skin friction or wall shear stress in fluid flow situations in a two-axis configuration. The sensor is fabricated by microelectromechanical system (MEMS) technology, enabling small size and multiple, low-cost reproductions. The sensors may be fabricated by bonding a sensing element wafer to a fluid-coupling element wafer. Using this layered machine structure provides a truly three-dimensional device.

Optimising Cell Aggregate Expansion in a Perfused Hollow Fibre Bioreactor via Mathematical Modelling

PubMed Central

Chapman, Lloyd A. C.; Shipley, Rebecca J.; Whiteley, Jonathan P.; Ellis, Marianne J.; Byrne, Helen M.; Waters, Sarah L.

2014-01-01

The need for efficient and controlled expansion of cell populations is paramount in tissue engineering. Hollow fibre bioreactors (HFBs) have the potential to meet this need, but only with improved understanding of how operating conditions and cell seeding strategy affect cell proliferation in the bioreactor. This study is designed to assess the effects of two key operating parameters (the flow rate of culture medium into the fibre lumen and the fluid pressure imposed at the lumen outlet), together with the cell seeding distribution, on cell population growth in a single-fibre HFB. This is achieved using mathematical modelling and numerical methods to simulate the growth of cell aggregates along the outer surface of the fibre in response to the local oxygen concentration and fluid shear stress. The oxygen delivery to the cell aggregates and the fluid shear stress increase as the flow rate and pressure imposed at the lumen outlet are increased. Although the increased oxygen delivery promotes growth, the higher fluid shear stress can lead to cell death. For a given cell type and initial aggregate distribution, the operating parameters that give the most rapid overall growth can be identified from simulations. For example, when aggregates of rat cardiomyocytes that can tolerate shear stresses of up to are evenly distributed along the fibre, the inlet flow rate and outlet pressure that maximise the overall growth rate are predicted to be in the ranges to (equivalent to to ) and to (or 15.6 psi to 15.7 psi) respectively. The combined effects of the seeding distribution and flow on the growth are also investigated and the optimal conditions for growth found to depend on the shear tolerance and oxygen demands of the cells. PMID:25157635

The Effect of a Shear Flow on the Uptake of LDL and Ac-LDL by Cultured Vascular Endothelial Cells

NASA Astrophysics Data System (ADS)

Niwa, Koichi; Karino, Takeshi

The effects of a shear flow on the uptake of fluorescence-labeled low-density lipoprotein (DiI-LDL), acetylated LDL (DiI-Ac-LDL), and lucifer yellow (LY; a tracer of fluid-phase endocytosis) by cultured bovine aortic ECs were studied using a rotating-disk shearing apparatus. It was found that 2hours’ exposure of ECs to a laminar shear flow that imposed ECs an area-mean shear stress of 10dynes/cm2 caused an increase in the uptake of DiI-LDL and LY. By contrast, the uptake of DiI-Ac-LDL was decreased by exposure of the ECs to a shear flow. Addition of dextran sulfate (DS), a competitive inhibitor of scavenger receptors, reversed the effect of a shear flow on the uptake of DiI-Ac-LDL, resulting in an increase by the imposition of a shear flow, while the uptake of DiI-LDL and LY remained unaffected. It was concluded that a shear flow promotes the endocytosis of DiI-LDL and LY by ECs, but suppresses the uptake of DiI-Ac-LDL by ECs by inhibiting scavenger receptor-mediated endocytosis.

Stirring Up an Elastic Fluid: Critical Viscosity of Xenon-2 (CVX-2)

NASA Astrophysics Data System (ADS)

Berg, Robert F.; Moldover, Michael R.; Zimmerli, Gregory A.

2002-12-01

Whipped cream stays in place even when turned upside down. Yet it readily flows through the nozzle of a spray can to reach the dessert plate. This demonstrates the phenomenon of shear thinning that is important to many industrial and physical processes. Paints, film emulsions, and other complex solutions that are highly viscous under normal conditions but become thin and flow easily under shear forces. A simple fluid, such as water, does not exhibit shear thinning under normal conditions. Very close to the liquid-vapor critical point, where the distinction between liquid and vapor disappears, the fluid becomes more complex and is predicted to display shear thinning. At the critical point, xenon atoms interact over long distances in a classical model of cooperative phenomena. Physicists rely on this system to learn how long-range order arises. The Critical Viscosity of Xenon Experiment (CVX-2) will measure the viscous behavior of xenon, a heavy inert gas used in flash lamps and ion rocket engines, at its critical point. Although it does not easily combine with other chemicals, its viscosity at the critical point can be used as a model for a range of fluids. Viscosity originates from the interactions of individual molecules. It is so complicated that, except for the simplest gas, it cannot be calculated accurately from theory. Tests with critical fluids can provide key data, but are limited on Earth because critical fluids are highly compressed by gravity. CVX-2 employs a tiny metal screen vibrating between two electrodes in a bath of critical xenon. The vibrations and how they dampen are used to measure viscosity. CVX flew on STS-85 (1997), where it revealed that, close to the critical point, the xenon is partly elastic: it can 'stretch' as well as flow. For STS-107, the hardware has been enhanced to determine if critical xenon is a shear-thinning fluid.

Stirring Up an Elastic Fluid: Critical Viscosity of Xenon-2 (CVX-2)

NASA Technical Reports Server (NTRS)

Berg, Robert F.; Moldover, Michael R.; Zimmerli, Gregory A.; Motil, Susan M. (Technical Monitor)

2002-01-01

Whipped cream stays in place even when turned upside down. Yet it readily flows through the nozzle of a spray can to reach the dessert plate. This demonstrates the phenomenon of shear thinning that is important to many industrial and physical processes. Paints, film emulsions, and other complex solutions that are highly viscous under normal conditions but become thin and flow easily under shear forces. A simple fluid, such as water, does not exhibit shear thinning under normal conditions. Very close to the liquid-vapor critical point, where the distinction between liquid and vapor disappears, the fluid becomes more complex and is predicted to display shear thinning. At the critical point, xenon atoms interact over long distances in a classical model of cooperative phenomena. Physicists rely on this system to learn how long-range order arises. The Critical Viscosity of Xenon Experiment (CVX-2) will measure the viscous behavior of xenon, a heavy inert gas used in flash lamps and ion rocket engines, at its critical point. Although it does not easily combine with other chemicals, its viscosity at the critical point can be used as a model for a range of fluids. Viscosity originates from the interactions of individual molecules. It is so complicated that, except for the simplest gas, it cannot be calculated accurately from theory. Tests with critical fluids can provide key data, but are limited on Earth because critical fluids are highly compressed by gravity. CVX-2 employs a tiny metal screen vibrating between two electrodes in a bath of critical xenon. The vibrations and how they dampen are used to measure viscosity. CVX flew on STS-85 (1997), where it revealed that, close to the critical point, the xenon is partly elastic: it can 'stretch' as well as flow. For STS-107, the hardware has been enhanced to determine if critical xenon is a shear-thinning fluid.

Physical aspects of computing the flow of a viscous fluid

NASA Technical Reports Server (NTRS)

Mehta, U. B.

1984-01-01

One of the main themes in fluid dynamics at present and in the future is going to be computational fluid dynamics with the primary focus on the determination of drag, flow separation, vortex flows, and unsteady flows. A computation of the flow of a viscous fluid requires an understanding and consideration of the physical aspects of the flow. This is done by identifying the flow regimes and the scales of fluid motion, and the sources of vorticity. Discussions of flow regimes deal with conditions of incompressibility, transitional and turbulent flows, Navier-Stokes and non-Navier-Stokes regimes, shock waves, and strain fields. Discussions of the scales of fluid motion consider transitional and turbulent flows, thin- and slender-shear layers, triple- and four-deck regions, viscous-inviscid interactions, shock waves, strain rates, and temporal scales. In addition, the significance and generation of vorticity are discussed. These physical aspects mainly guide computations of the flow of a viscous fluid.

Dynamic Transitions and Baroclinic Instability for 3D Continuously Stratified Boussinesq Flows

NASA Astrophysics Data System (ADS)

Şengül, Taylan; Wang, Shouhong

2018-02-01

The main objective of this article is to study the nonlinear stability and dynamic transitions of the basic (zonal) shear flows for the three-dimensional continuously stratified rotating Boussinesq model. The model equations are fundamental equations in geophysical fluid dynamics, and dynamics associated with their basic zonal shear flows play a crucial role in understanding many important geophysical fluid dynamical processes, such as the meridional overturning oceanic circulation and the geophysical baroclinic instability. In this paper, first we derive a threshold for the energy stability of the basic shear flow, and obtain a criterion for local nonlinear stability in terms of the critical horizontal wavenumbers and the system parameters such as the Froude number, the Rossby number, the Prandtl number and the strength of the shear flow. Next, we demonstrate that the system always undergoes a dynamic transition from the basic shear flow to either a spatiotemporal oscillatory pattern or circle of steady states, as the shear strength of the basic flow crosses a critical threshold. Also, we show that the dynamic transition can be either continuous or catastrophic, and is dictated by the sign of a transition number, fully characterizing the nonlinear interactions of different modes. Both the critical shear strength and the transition number are functions of the system parameters. A systematic numerical method is carried out to explore transition in different flow parameter regimes. In particular, our numerical investigations show the existence of a hypersurface which separates the parameter space into regions where the basic shear flow is stable and unstable. Numerical investigations also yield that the selection of horizontal wave indices is determined only by the aspect ratio of the box. We find that the system admits only critical eigenmodes with roll patterns aligned with the x-axis. Furthermore, numerically we encountered continuous transitions to multiple steady states, as well as continuous and catastrophic transitions to spatiotemporal oscillations.

Shear-induced clustering of Brownian colloids in associative polymer networks at moderate Péclet number

NASA Astrophysics Data System (ADS)

Kim, Juntae; Helgeson, Matthew E.

2016-08-01

We investigate shear-induced clustering and its impact on fluid rheology in polymer-colloid mixtures at moderate colloid volume fraction. By employing a thermoresponsive system that forms associative polymer-colloid networks, we present experiments of rheology and flow-induced microstructure on colloid-polymer mixtures in which the relative magnitudes of the time scales associated with relaxation of viscoelasticity and suspension microstructure are widely and controllably varied. In doing so, we explore several limits of relative magnitude of the relevant dimensionless shear rates, the Weissenberg number Wi and the Péclet number Pe. In all of these limits, we find that the fluid exhibits two distinct regimes of shear thinning at relatively low and high shear rates, in which the rheology collapses by scaling with Wi and Pe, respectively. Using three-dimensionally-resolved flow small-angle neutron scattering measurements, we observe clustering of the suspension above a critical shear rate corresponding to Pe ˜0.1 over a wide range of fluid conditions, having anisotropy with projected orientation along both the vorticity and compressional axes of shear. The degree of anisotropy is shown to scale with Pe. From this we formulate an empirical model for the shear stress and viscosity, in which the viscoelastic network stress is augmented by an asymptotic shear thickening contribution due to hydrodynamic clustering. Overall, our results elucidate the significant role of hydrodynamic interactions in contributing to shear-induced clustering of Brownian suspensions in viscoelastic liquids.

Numerical Investigation of Oxygenated and Deoxygenated Blood Flow through a Tapered Stenosed Arteries in Magnetic Field.

PubMed

Abdollahzadeh Jamalabadi, M Y; Akbari Bidokhti, Amin Ali; Khak Rah, Hamid; Vaezi, Siavash; Hooshmand, Payam

2016-01-01

Current paper is focused on transient modeling of blood flow through a tapered stenosed arteries surrounded a by solenoid under the presence of heat transfer. The oxygenated and deoxygenated blood are considered here by the Newtonian and Non-Newtonian fluid (power law and Carreau-Yasuda) models. The governing equations of bio magnetic fluid flow for an incompressible, laminar, homogeneous, non-Newtonian are solved by finite volume method with SIMPLE algorithm for structured grid. Both magnetization and electric current source terms are well thought-out in momentum and energy equations. The effects of fluid viscosity model, Hartmann number, and magnetic number on wall shear stress, shearing stress at the stenosis throat and maximum temperature of the system are investigated and are optimized. The current study results are in agreement with some of the existing findings in the literature and are useful in thermal and mechanical design of spatially varying magnets to control the drug delivery and biomagnetic fluid flows through tapered arteries.

Modeling and measuring non-Newtonian shear flows of soft interfaces

NASA Astrophysics Data System (ADS)

Lopez, Juan; Raghunandan, Aditya; Underhill, Patrick; Hirsa, Amir

2017-11-01

Soft interfaces of polymers, particles, and proteins between fluid phases are ubiquitous in industrial and natural processes. The flow response of such systems to deformation is often not linear, as one would expect for Newtonian interfaces. The resistance to (pure shear) flow of interfaces is generally characterized by a single intrinsic material property, the surface shear viscosity. Predicted shear responses of Newtonian interfaces have achieved consensus across a wide range of flow conditions and measurement devices, when the nonlinear hydrodynamic coupling to the bulk phase is correctly accounted for. However, predicting the flows of sheared non-Newtonian interfaces remains a challenge. Here, we introduce a computational model that incorporates a non-Newtonian constitutive equation for the sheared interface and properly accounts for the coupled interfacial and bulk phase flows. We compare predictions to experiments performed with a model phospholipid system, DPPC - the main constituent of mammalian lung surfactant. Densely packed films of DPPC are directly sheared in a knife-edge surface viscometer. Yield-stress and shear thinning behaviors are shown to be accurately captured across hydrodynamic regimes straddling the Stokes flow limit to inertia dominated flows. Supported by NASA Grant NNX13AQ22G.

Numerical modeling of spray combustion with an advanced VOF method

NASA Technical Reports Server (NTRS)

Chen, Yen-Sen; Shang, Huan-Min; Shih, Ming-Hsin; Liaw, Paul

1995-01-01

This paper summarizes the technical development and validation of a multiphase computational fluid dynamics (CFD) numerical method using the volume-of-fluid (VOF) model and a Lagrangian tracking model which can be employed to analyze general multiphase flow problems with free surface mechanism. The gas-liquid interface mass, momentum and energy conservation relationships are modeled by continuum surface mechanisms. A new solution method is developed such that the present VOF model can be applied for all-speed flow regimes. The objectives of the present study are to develop and verify the fractional volume-of-fluid cell partitioning approach into a predictor-corrector algorithm and to demonstrate the effectiveness of the present approach by simulating benchmark problems including laminar impinging jets, shear coaxial jet atomization and shear coaxial spray combustion flows.

Flow Enhancement due to Elastic Turbulence in Channel Flows of Shear Thinning Fluids

NASA Astrophysics Data System (ADS)

Bodiguel, Hugues; Beaumont, Julien; Machado, Anaïs; Martinie, Laetitia; Kellay, Hamid; Colin, Annie

2015-01-01

We explore the flow of highly shear thinning polymer solutions in straight geometry. The strong variations of the normal forces close to the wall give rise to an elastic instability. We evidence a periodic motion close the onset of the instability, which then evolves towards a turbulentlike flow at higher flow rates. Strikingly, we point out that this instability induces genuine drag reduction due to the homogenization of the viscosity profile by the turbulent flow.

Flow enhancement due to elastic turbulence in channel flows of shear thinning fluids.

PubMed

Bodiguel, Hugues; Beaumont, Julien; Machado, Anaïs; Martinie, Laetitia; Kellay, Hamid; Colin, Annie

2015-01-16

We explore the flow of highly shear thinning polymer solutions in straight geometry. The strong variations of the normal forces close to the wall give rise to an elastic instability. We evidence a periodic motion close the onset of the instability, which then evolves towards a turbulentlike flow at higher flow rates. Strikingly, we point out that this instability induces genuine drag reduction due to the homogenization of the viscosity profile by the turbulent flow.

High shear microfluidics and its application in rheological measurement

NASA Astrophysics Data System (ADS)

Kang, Kai; Lee, L. James; Koelling, Kurt W.

2005-02-01

High shear rheology was explored experimentally in microchannels (150×150 μm). Two aqueous polymer solutions, polyethylene oxide (viscoelastic fluid) and hydroxyethyl cellulose (viscous fluid) were tested. Bagley correction was applied to remove the end effect. Wall slip was investigated with Mooney’s analysis. Shear rates as high as 106 s-1 were obtained in the pressure-driven microchannel flow, allowing a smooth extension of the low shear rheological data obtained from the conventional rheometers. At high shear rates, polymer degradation was observed for PEO solutions at a critical microchannel wall shear stress of 4.1×103 Pa. Stresses at the ends of the microchannel also contributed to PEO degradation significantly.

Numerical evaluation of a single ellipsoid motion in Newtonian and power-law fluids

NASA Astrophysics Data System (ADS)

Férec, Julien; Ausias, Gilles; Natale, Giovanniantonio

2018-05-01

A computational model is developed for simulating the motion of a single ellipsoid suspended in a Newtonian and power-law fluid, respectively. Based on a finite element method (FEM), the approach consists in seeking solutions for the linear and angular particle velocities using a minimization algorithm, such that the net hydrodynamic force and torque acting on the ellipsoid are zero. For a Newtonian fluid subjected to a simple shear flow, the Jeffery's predictions are recovered at any aspect ratios. The motion of a single ellipsoidal fiber is found to be slightly disturbed by the shear-thinning character of the suspending fluid, when compared with the Jeffery's solutions. Surprisingly, the perturbation can be completely neglected for a particle with a large aspect ratio. Furthermore, the particle centroid is also found to translate with the same linear velocity as the undisturbed simple shear flow evaluated at particle centroid. This is confirmed by recent works based on experimental investigations and modeling approach (1-2).

Nonlinear dynamics and rheology of active fluids: simulations in two dimensions.

PubMed

Fielding, S M; Marenduzzo, D; Cates, M E

2011-04-01

We report simulations of a continuum model for (apolar, flow aligning) active fluids in two dimensions. Both free and anchored boundary conditions are considered, at parallel confining walls that are either static or moving at fixed relative velocity. We focus on extensile materials and find that steady shear bands, previously shown to arise ubiquitously in one dimension for the active nematic phase at small (or indeed zero) shear rate, are generally replaced in two dimensions by more complex flow patterns that can be stationary, oscillatory, or apparently chaotic. The consequences of these flow patterns for time-averaged steady-state rheology are examined. ©2011 American Physical Society

Studies in turbulence

NASA Technical Reports Server (NTRS)

Gatski, Thomas B. (Editor); Sarkar, Sutanu (Editor); Speziale, Charles G. (Editor)

1992-01-01

Various papers on turbulence are presented. Individual topics addressed include: modeling the dissipation rate in rotating turbulent flows, mapping closures for turbulent mixing and reaction, understanding turbulence in vortex dynamics, models for the structure and dynamics of near-wall turbulence, complexity of turbulence near a wall, proper orthogonal decomposition, propagating structures in wall-bounded turbulence flows. Also discussed are: constitutive relation in compressible turbulence, compressible turbulence and shock waves, direct simulation of compressible turbulence in a shear flow, structural genesis in wall-bounded turbulence flows, vortex lattice structure of turbulent shear slows, etiology of shear layer vortices, trilinear coordinates in fluid mechanics.

Influence of the hole geometry on the flow distribution in ventricular catheters for hydrocephalus.

PubMed

Giménez, Ángel; Galarza, Marcelo; Pellicer, Olga; Valero, José; Amigó, José M

2016-07-15

Hydrocephalus is a medical condition consisting of an abnormal accumulation of cerebrospinal fluid within the brain. A catheter is inserted in one of the brain ventricles and then connected to an external valve to drain the excess of cerebrospinal fluid. The main drawback of this technique is that, over time, the ventricular catheter ends up getting blocked by the cells and macromolecules present in the cerebrospinal fluid. A crucial factor influencing this obstruction is a non-uniform flow pattern through the catheter, since it facilitates adhesion of suspended particles to the walls. In this paper we focus on the effects that tilted holes as well as conical holes have on the flow distribution and shear stress. We have carried out 3D computational simulations to study the effect of the hole geometry on the cerebrospinal fluid flow through ventricular catheters. All the simulations were done with the OpenFOAM® toolbox. In particular, three different groups of models were investigated by varying (i) the tilt angles of the holes, (ii) the inner and outer diameters of the holes, and (iii) the distances between the so-called hole segments. The replacement of cylindrical holes by conical holes was found to have a strong influence on the flow distribution and to lower slightly the shear stress. Tilted holes did not involve flow distribution changes when the hole segments are sufficiently separated, but the mean shear stress was certainly reduced. The authors present new results about the behavior of the fluid flow through ventricular catheters. These results complete earlier work on this topic by adding the influence of the hole geometry. The overall objective pursued by this research is to provide guidelines to improve existing commercially available ventricular catheters.

Orientational dynamics of a triaxial ellipsoid in simple shear flow: Influence of inertia.

PubMed

Rosén, Tomas; Kotsubo, Yusuke; Aidun, Cyrus K; Do-Quang, Minh; Lundell, Fredrik

2017-07-01

The motion of a single ellipsoidal particle in simple shear flow can provide valuable insights toward understanding suspension flows with nonspherical particles. Previously, extensive studies have been performed on the ellipsoidal particle with rotational symmetry, a so-called spheroid. The nearly prolate ellipsoid (one major and two minor axes of almost equal size) is known to perform quasiperiodic or even chaotic orbits in the absence of inertia. With small particle inertia, the particle is also known to drift toward this irregular motion. However, it is not previously understood what effects from fluid inertia could be, which is of highest importance for particles close to neutral buoyancy. Here, we find that fluid inertia is acting strongly to suppress the chaotic motion and only very weak fluid inertia is sufficient to stabilize a rotation around the middle axis. The mechanism responsible for this transition is believed to be centrifugal forces acting on fluid, which is dragged along with the rotational motion of the particle. With moderate fluid inertia, it is found that nearly prolate triaxial particles behave similarly to the perfectly spheroidal particles. Finally, we also are able to provide predictions about the stable rotational states for the general triaxial ellipsoid in simple shear with weak inertia.

Oscillatory fluid flow induces the osteogenic lineage commitment of mesenchymal stem cells: The effect of shear stress magnitude, frequency, and duration.

PubMed

Stavenschi, Elena; Labour, Marie-Noelle; Hoey, David A

2017-04-11

A potent regulator of bone anabolism is physical loading. However, it is currently unclear whether physical stimuli such as fluid shear within the marrow cavity is sufficient to directly drive the osteogenic lineage commitment of resident mesenchymal stem cells (MSC). Therefore, the objective of the study is to employ a systematic analysis of oscillatory fluid flow (OFF) parameters predicted to occur in vivo on early MSC osteogenic responses and late stage lineage commitment. MSCs were exposed to OFF of 1Pa, 2Pa and 5Pa magnitudes at frequencies of 0.5Hz, 1Hz and 2Hz for 1h, 2h and 4h of stimulation. Our findings demonstrate that OFF elicits a positive osteogenic response in MSCs in a shear stress magnitude, frequency, and duration dependent manner that is gene specific. Based on the mRNA expression of osteogenic markers Cox2, Runx2 and Opn after short-term fluid flow stimulation, we identified that a regime of 2Pa shear magnitude and 2Hz frequency induces the most robust and reliable upregulation in osteogenic gene expression. Furthermore, long-term mechanical stimulation utilising this regime, elicits a significant increase in collagen and mineral deposition when compared to static control demonstrating that mechanical stimuli predicted within the marrow is sufficient to directly drive osteogenesis. Copyright © 2017. Published by Elsevier Ltd.

Shear stress upregulates regeneration-related immediate early genes in liver progenitors in 3D ECM-like microenvironments.

PubMed

Nishii, Kenichiro; Brodin, Erik; Renshaw, Taylor; Weesner, Rachael; Moran, Emma; Soker, Shay; Sparks, Jessica L

2018-05-01

The role of fluid stresses in activating the hepatic stem/progenitor cell regenerative response is not well understood. This study hypothesized that immediate early genes (IEGs) with known links to liver regeneration will be upregulated in liver progenitor cells (LPCs) exposed to in vitro shear stresses on the order of those produced from elevated interstitial flow after partial hepatectomy. The objectives were: (1) to develop a shear flow chamber for application of fluid stress to LPCs in 3D culture; and (2) to determine the effects of fluid stress on IEG expression in LPCs. Two hours of shear stress exposure at ∼4 dyn/cm 2 was applied to LPCs embedded individually or as 3D spheroids within a hyaluronic acid/collagen I hydrogel. Results were compared against static controls. Quantitative reverse transcriptase polymerase chain reaction was used to evaluate the effect of experimental treatments on gene expression. Twenty-nine genes were analyzed, including IEGs and other genes linked to liver regeneration. Four IEGs (CFOS, IP10, MKP1, ALB) and three other regeneration-related genes (WNT, VEGF, EpCAM) were significantly upregulated in LPCs in response to fluid mechanical stress. LPCs maintained an early to intermediate stage of differentiation in spheroid culture in the absence of the hydrogel, and addition of the gel initiated cholangiocyte differentiation programs which were abrogated by the onset of flow. Collectively the flow-upregulated genes fit the pattern of an LPC-mediated proliferative/regenerative response. These results suggest that fluid stresses are potentially important regulators of the LPC-mediated regeneration response in liver. © 2017 Wiley Periodicals, Inc.

Extrema principles of entrophy production and energy dissipation in fluid mechanics

NASA Technical Reports Server (NTRS)

Horne, W. Clifton; Karamcheti, Krishnamurty

1988-01-01

A survey is presented of several extrema principles of energy dissipation as applied to problems in fluid mechanics. An exact equation is derived for the dissipation function of a homogeneous, isotropic, Newtonian fluid, with terms associated with irreversible compression or expansion, wave radiation, and the square of the vorticity. By using entropy extrema principles, simple flows such as the incompressible channel flow and the cylindrical vortex are identified as minimal dissipative distributions. The principal notions of stability of parallel shear flows appears to be associated with a maximum dissipation condition. These different conditions are consistent with Prigogine's classification of thermodynamic states into categories of equilibrium, linear nonequilibrium, and nonlinear nonequilibrium thermodynamics; vortices and acoustic waves appear as examples of dissipative structures. The measurements of a typical periodic shear flow, the rectangular wall jet, show that direct measurements of the dissipative terms are possible.

Experimental and modeling study of Newtonian and non-Newtonian fluid flow in pore network micromodels.

PubMed

Perrin, Christian L; Tardy, Philippe M J; Sorbie, Ken S; Crawshaw, John C

2006-03-15

The in situ rheology of polymeric solutions has been studied experimentally in etched silicon micromodels which are idealizations of porous media. The rectangular channels in these etched networks have dimensions typical of pore sizes in sandstone rocks. Pressure drop/flow rate relations have been measured for water and non-Newtonian hydrolyzed-polyacrylamide (HPAM) solutions in both individual straight rectangular capillaries and in networks of such capillaries. Results from these experiments have been analyzed using pore-scale network modeling incorporating the non-Newtonian fluid mechanics of a Carreau fluid. Quantitative agreement is seen between the experiments and the network calculations in the Newtonian and shear-thinning flow regions demonstrating that the 'shift factor,'alpha, can be calculated a priori. Shear-thickening behavior was observed at higher flow rates in the micromodel experiments as a result of elastic effects becoming important and this remains to be incorporated in the network model.

A Microfluidic-Based Multi-Shear Device for Investigating the Effects of Low Fluid-Induced Stresses on Osteoblasts

PubMed Central

Yu, Weiliang; Qu, Hong; Hu, Guoqing; Zhang, Qian; Song, Kui; Guan, Haijie; Liu, Tingjiao; Qin, Jianhua

2014-01-01

Interstitial fluid flow (IFF) within the extracellular matrix (ECM) produces low magnitude shear stresses on cells. Fluid flow-induced stress (FSS) plays an important role during tissue morphogenesis. To investigate the effect of low FSS generated by IFF on cells, we developed a microfluidic-based cell culture device that can generate multiple low shear stresses. By changing the length and width of the flow-in channels, different continuous low level shear stresses could be generated in individual cell culture chambers. Numerical calculations demonstrate uniform shear stress distributions of the major cell culture area of each chamber. This calculation is further confirmed by the wall shear stress curves. The effects of low FSS on MC3T3-E1 proliferation and differentiation were studied using this device. It was found that FSS ranging from 1.5 to 52.6 µPa promoted MC3T3-E1 proliferation and differentiation, but FSS over 412 µPa inhibited the proliferation and differentiation of MC3T3-E1 cells. FSS ranging from 1.5 to 52.6 µPa also increased the expression of Runx2, a key transcription factor regulating osteoblast differentiation. It is suggested that Runx2 might be an important regulator in low FSS-induced MC3T3-E1 differentiation. This device allows for detailed study of the effect of low FSS on the behaviors of cells; thus, it would be a useful tool for analysis of the effects of IFF-induced shear stresses on cells. PMID:24587156

Direct numerical simulation of incompressible acceleration-driven variable-density turbulence

NASA Astrophysics Data System (ADS)

Gat, Ilana; Matheou, Georgios; Chung, Daniel; Dimotakis, Paul

2015-11-01

Fully developed turbulence in variable-density flow driven by an externally imposed acceleration field, e.g., gravity, is fundamental in many applications, such as inertial confinement fusion, geophysics, and astrophysics. Aspects of this turbulence regime are poorly understood and are of interest to fluid modeling. We investigate incompressible acceleration-driven variable-density turbulence by a series of direct numerical simulations of high-density fluid in-between slabs of low-density fluid, in a triply-periodic domain. A pseudo-spectral numerical method with a Helmholtz-Hodge decomposition of the pressure field, which ensures mass conservation, is employed, as documented in Chung & Pullin (2010). A uniform dynamic viscosity and local Schmidt number of unity are assumed. This configuration encapsulates a combination of flow phenomena in a temporally evolving variable-density shear flow. Density ratios up to 10 and Reynolds numbers in the fully developed turbulent regime are investigated. The temporal evolution of the vertical velocity difference across the shear layer, shear-layer growth, mean density, and Reynolds number are discussed. Statistics of Lagrangian accelerations of fluid elements and of vorticity as a function of the density ratio are also presented. This material is based upon work supported by the AFOSR, the DOE, the NSF GRFP, and Caltech.

Precessing rotating flows with additional shear: stability analysis.

PubMed

Salhi, A; Cambon, C

2009-03-01

We consider unbounded precessing rotating flows in which vertical or horizontal shear is induced by the interaction between the solid-body rotation (with angular velocity Omega(0)) and the additional "precessing" Coriolis force (with angular velocity -epsilonOmega(0)), normal to it. A "weak" shear flow, with rate 2epsilon of the same order of the Poincaré "small" ratio epsilon , is needed for balancing the gyroscopic torque, so that the whole flow satisfies Euler's equations in the precessing frame (the so-called admissibility conditions). The base flow case with vertical shear (its cross-gradient direction is aligned with the main angular velocity) corresponds to Mahalov's [Phys. Fluids A 5, 891 (1993)] precessing infinite cylinder base flow (ignoring boundary conditions), while the base flow case with horizontal shear (its cross-gradient direction is normal to both main and precessing angular velocities) corresponds to the unbounded precessing rotating shear flow considered by Kerswell [Geophys. Astrophys. Fluid Dyn. 72, 107 (1993)]. We show that both these base flows satisfy the admissibility conditions and can support disturbances in terms of advected Fourier modes. Because the admissibility conditions cannot select one case with respect to the other, a more physical derivation is sought: Both flows are deduced from Poincaré's [Bull. Astron. 27, 321 (1910)] basic state of a precessing spheroidal container, in the limit of small epsilon . A Rapid distortion theory (RDT) type of stability analysis is then performed for the previously mentioned disturbances, for both base flows. The stability analysis of the Kerswell base flow, using Floquet's theory, is recovered, and its counterpart for the Mahalov base flow is presented. Typical growth rates are found to be the same for both flows at very small epsilon , but significant differences are obtained regarding growth rates and widths of instability bands, if larger epsilon values, up to 0.2, are considered. Finally, both flow cases are briefly discussed in view of a subsequent nonlinear study using pseudospectral direct numerical simulations, which is a natural continuation of RDT.

Granular-flow rheology: Role of shear-rate number in transition regime

USGS Publications Warehouse

Chen, C.-L.; Ling, C.-H.

1996-01-01

This paper examines the rationale behind the semiempirical formulation of a generalized viscoplastic fluid (GVF) model in the light of the Reiner-Rivlin constitutive theory and the viscoplastic theory, thereby identifying the parameters that control the rheology of granular flow. The shear-rate number (N) proves to be among the most significant parameters identified from the GVF model. As N ??? 0 and N ??? ???, the GVF model can reduce asymptotically to the theoretical stress versus shear-rate relations in the macroviscous and graininertia regimes, respectively, where the grain concentration (C) also plays a major role in the rheology of granular flow. Using available data obtained from the rotating-cylinder experiments of neutrally buoyant solid spheres dispersing in an interstitial fluid, the shear stress for granular flow in transition between the two regimes proves dependent on N and C in addition to some material constants, such as the coefficient of restitution. The insufficiency of data on rotating-cylinder experiments cannot presently allow the GVF model to predict how a granular flow may behave in the entire range of N; however, the analyzed data provide an insight on the interrelation among the relevant dimensionless parameters.

Pore scale simulations for the extension of the Darcy-Forchheimer law to shear thinning fluids

NASA Astrophysics Data System (ADS)

Tosco, Tiziana; Marchisio, Daniele; Lince, Federica; Boccardo, Gianluca; Sethi, Rajandrea

2014-05-01

Flow of non-Newtonian fluids through porous media at high Reynolds numbers is often encountered in chemical, pharmaceutical and food as well as petroleum and groundwater engineering and in many other industrial applications (1 - 2). In particular, the use of shear thinning polymeric solutions has been recently proposed to improve colloidal stability of micro- and nanoscale zerovalent iron particles (MZVI and NZVI) for groundwater remediation. In all abovementioned applications, it is of paramount importance to correctly predict the pressure drop resulting from non-Newtonian fluid flow through the porous medium. For small Reynolds numbers, usually up to 1, typical of laboratory column tests, the extended Darcy law is known to be applicable also to non Newtonian fluids, provided that all non-Newtonian effects are lumped together into a proper viscosity parameter (1,3). For higher Reynolds numbers (eg. close to the injection wells) non linearities between pressure drop and flow rate arise, and the Darcy-Forchheimer law holds for Newtonian fluids, while for non-Newtonian fluids, it has been demonstrated that, at least for simple rheological models (eg. power law fluids) a generalized Forchheimer law can be applied, even if the determination of the flow parameters (permeability K, inertial coefficient β, and equivalent viscosity) is not straightforward. This work (co-funded by European Union project AQUAREHAB FP7 - Grant Agreement Nr. 226565) aims at proposing an extended formulation of the Darcy-Forchheimer law also for shear-thinning fluids, and validating it against results of pore-scale simulations via computational fluid dynamics (4). Flow simulations were performed using Fluent 12.0 on four different 2D porous domains for Newtonian and non-Newtonian fluids (Cross, Ellis and Carreau models). The micro-scale flow simulation results are analyzed in terms of 'macroscale' pressure drop between inlet and outlet of the model domain as a function of flow rate. The results of flow simulations show the superposition of two contributions to pressure drops: one, strictly related to the non-Newtonian properties of the fluid, dominates at low Reynolds numbers, while a quadratic one, arising at higher Reynolds numbers, is dependent only on the porous medium properties. The results suggest that, for Newtonian flow, the porous medium can be fully described by two macroscopic parameters, namely permeability K and inertial coefficient β. Conversely, for non-Newtonian flow, an additional parameter is required, represented by the shift factor α, which depends on the properties of both porous medium and fluid, which is not easy to be determined in laboratory tests, but can be in turn calculated from 2D or 3D pore-scale flow simulations, following the approach which was adopted in this work. References 1. Sorbie, K.S. Polymer-improved oil recovery; Blackie ; CRC Press: Glasgow, Boca Raton, Fla., 1991. 2. Xue, D.; Sethi, R. Viscoelastic gels of guar and xanthan gum mixtures provide long-term stabilization of iron micro- and nanoparticles. J Nanopart Res 2012, 14(11). 3. Bird, R.B.; Armstrong, R.C.; Hassager, O. Dynamics of polymeric liquids. Volume 1. Fluid mechanics; John Wiley and Sons Inc.: New York - NY, 1977. 4. Tosco, T.; Marchisio, D.L.; Lince, F.; Sethi, R. Extension of the Darcy-Forchheimer Law for Shear-Thinning Fluids and Validation via Pore-Scale Flow Simulations. Transport in Porous Media 2013, 96(1), 1-20.

The Einstein viscosity with fluid elasticity

NASA Astrophysics Data System (ADS)

Einarsson, Jonas; Yang, Mengfei; Shaqfeh, Eric S. G.

2017-11-01

We give the first correction to the suspension viscosity due to fluid elasticity for a dilute suspension of spheres in a viscoelastic medium. Our perturbation theory is valid to O (Wi2) in the Weissenberg number Wi = γ . λ , where γ is the typical magnitude of the suspension velocity gradient, and λ is the relaxation time of the viscoelastic fluid. For shear flow we find that the suspension shear-thickens due to elastic stretching in strain `hot spots' near the particle, despite the fact that the stress inside the particles decreases relative to the Newtonian case. We thus argue that it is crucial to correctly model the extensional rheology of the suspending medium to predict the shear rheology of the suspension. For uniaxial extensional flow we correct existing results at O (Wi) , and find dramatic strain-rate thickening at O (Wi2) . We validate our theory with fully resolved numerical simulations.

Einstein viscosity with fluid elasticity

NASA Astrophysics Data System (ADS)

Einarsson, Jonas; Yang, Mengfei; Shaqfeh, Eric S. G.

2018-01-01

We give the first correction to the suspension viscosity due to fluid elasticity for a dilute suspension of spheres in a viscoelastic medium. Our perturbation theory is valid to O (ϕ Wi2) in the particle volume fraction ϕ and the Weissenberg number Wi =γ ˙λ , where γ ˙ is the typical magnitude of the suspension velocity gradient, and λ is the relaxation time of the viscoelastic fluid. For shear flow we find that the suspension shear-thickens due to elastic stretching in strain "hot spots" near the particle, despite the fact that the stress inside the particles decreases relative to the Newtonian case. We thus argue that it is crucial to correctly model the extensional rheology of the suspending medium to predict the shear rheology of the suspension. For uniaxial extensional flow we correct existing results at O (ϕ Wi ) , and find dramatic strain-rate thickening at O (ϕ Wi2) . We validate our theory with fully resolved numerical simulations.

Molecular shear heating and vortex dynamics in thermostatted two dimensional Yukawa liquids

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gupta, Akanksha; Ganesh, Rajaraman, E-mail: ganesh@ipr.res.in; Joy, Ashwin

2016-07-15

It is well known that two-dimensional macroscale shear flows are susceptible to instabilities leading to macroscale vortical structures. The linear and nonlinear fate of such a macroscale flow in a strongly coupled medium is a fundamental problem. A popular example of a strongly coupled medium is a dusty plasma, often modelled as a Yukawa liquid. Recently, laboratory experiments and molecular dynamics (MD) studies of shear flows in strongly coupled Yukawa liquids indicated the occurrence of strong molecular shear heating, which is found to reduce the coupling strength exponentially leading to the destruction of macroscale vorticity. To understand the vortex dynamicsmore » of strongly coupled molecular fluids undergoing macroscale shear flows and molecular shear heating, MD simulation has been performed, which allows the macroscopic vortex dynamics to evolve, while at the same time “removes” the microscopically generated heat without using the velocity degrees of freedom. We demonstrate that by using a configurational thermostat in a novel way, the microscale heat generated by shear flow can be thermostatted out efficiently without compromising the large scale vortex dynamics. In the present work, using MD simulations, a comparative study of shear flow evolution in Yukawa liquids in the presence and absence of molecular or microscopic heating is presented for a prototype shear flow, namely, Kolmogorov flow.« less

High strength semi-active energy absorbers using shear- and mixedmode operation at high shear rates

NASA Astrophysics Data System (ADS)

Becnel, Andrew C.

This body of research expands the design space of semi-active energy absorbers for shock isolation and crash safety by investigating and characterizing magnetorheological fluids (MRFs) at high shear rates ( > 25,000 1/s) under shear and mixed-mode operation. Magnetorheological energy absorbers (MREAs) work well as adaptive isolators due to their ability to quickly and controllably adjust to changes in system mass or impact speed while providing fail-safe operation. However, typical linear stroking MREAs using pressure-driven flows have been shown to exhibit reduced controllability as impact speed (shear rate) increases. The objective of this work is to develop MREAs that improve controllability at high shear rates by using pure shear and mixed shear-squeeze modes of operation, and to present the fundamental theory and models of MR fluids under these conditions. A proof of concept instrument verified that the MR effect persists in shear mode devices at shear rates corresponding to low speed impacts. This instrument, a concentric cylinder Searle cell magnetorheometer, was then used to characterize three commercially available MRFs across a wide range of shear rates, applied magnetic fields, and temperatures. Characterization results are presented both as flow curves according to established practice, and as an alternate nondimensionalized analysis based on Mason number. The Mason number plots show that, with appropriate correction coefficients for operating temperature, the varied flow curve data can be collapsed to a single master curve. This work represents the first shear mode characterization of MRFs at shear rates over 10 times greater than available with commercial rheometers, as well as the first validation of Mason number analysis to high shear rate flows in MRFs. Using the results from the magnetorheometer, a full scale rotary vane MREA was developed as part of the Lightweight Magnetorheological Energy Absorber System (LMEAS) for an SH-60 Seahawk helicopter crew seat. Characterization tests were carried out on the LMEAS using a 40 vol% MRF used in the previous magnetorheometer tests. These were analyzed using both flow curves and apparent viscosity vs. Mason number diagrams. The nondimensionalized Mason number analysis resulted in data for all conditions of temperature, fluid composition, and shear rate, to collapse onto a single characteristic or master curve. Significantly, the temperature corrected Mason number results from both the bench top magnetorheometer and full scale rotary vane MREA collapse to the same master curve. This enhances the ability of designers of MRFs and MREAs to safely and effectively apply characterization data collected in low shear rate, controlled temperature environments to operational environments that may be completely different. Finally, the Searle cell magnetorheometer was modified with an enforced eccentricity to work in both squeeze and shear modes simultaneously to achieve so called squeeze strengthening of the working MRF, thereby increasing the apparent yield stress and the specific energy absorption. By squeezing the active MR fluid, particles undergo compression-assisted aggregation into stronger, more robust columns which resist shear better than single chains. A hybrid model describing the squeeze strengthening behavior is developed, and recommendations are made for using squeeze strengthening to improve practical MREA devices.

Effect of non-Newtonian viscosity on the fluid-dynamic characteristics in stenotic vessels

NASA Astrophysics Data System (ADS)

Huh, Hyung Kyu; Ha, Hojin; Lee, Sang Joon

2015-08-01

Although blood is known to have shear-thinning and viscoelastic properties, the effects of such properties on the hemodynamic characteristics in various vascular environments are not fully understood yet. For a quantitative hemodynamic analysis, the refractive index of a transparent blood analogue needs to be matched with that of the flowing conduit in order to minimize the errors according to the distortion of the light. In this study, three refractive index-matched blood analogue fluids with different viscosities are prepared—one Newtonian and two non-Newtonian analogues—which correspond to healthy blood with 45 % hematocrit (i.e., normal non-Newtonian) and obese blood with higher viscosity (i.e., abnormal non-Newtonian). The effects of the non-Newtonian rheological properties of the blood analogues on the hemodynamic characteristics in the post-stenosis region of an axisymmetric stenosis model are experimentally investigated using particle image velocimetry velocity field measurement technique and pathline flow visualization. As a result, the centerline jet flow from the stenosis apex is suppressed by the shear-thinning feature of the blood analogues when the Reynolds number is smaller than 500. The lengths of the recirculation zone for abnormal and normal non-Newtonian blood analogues are 3.67 and 1.72 times shorter than that for the Newtonian analogue at Reynolds numbers smaller than 200. The Reynolds number of the transition from laminar to turbulent flow for all blood analogues increases as the shear-thinning feature increases, and the maximum wall shear stresses in non-Newtonian fluids are five times greater than those in Newtonian fluids. However, the shear-thinning effect on the hemodynamic characteristics is not significant at Reynolds numbers higher than 1000. The findings of this study on refractive index-matched non-Newtonian blood analogues can be utilized in other in vitro experiments, where non-Newtonian features dominantly affect the flow characteristics.

Transient shear banding in the nematic dumbbell model of liquid crystalline polymers

NASA Astrophysics Data System (ADS)

Adams, J. M.; Corbett, D.

2018-05-01

In the shear flow of liquid crystalline polymers (LCPs) the nematic director orientation can align with the flow direction for some materials but continuously tumble in others. The nematic dumbbell (ND) model was originally developed to describe the rheology of flow-aligning semiflexible LCPs, and flow-aligning LCPs are the focus in this paper. In the shear flow of monodomain LCPs, it is usually assumed that the spatial distribution of the velocity is uniform. This is in contrast to polymer solutions, where highly nonuniform spatial velocity profiles have been observed in experiments. We analyze the ND model, with an additional gradient term in the constitutive model, using a linear stability analysis. We investigate the separate cases of constant applied shear stress and constant applied shear rate. We find that the ND model has a transient flow instability to the formation of a spatially inhomogeneous flow velocity for certain starting orientations of the director. We calculate the spatially resolved flow profile in both constant applied stress and constant applied shear rate in start up from rest, using a model with one spatial dimension to illustrate the flow behavior of the fluid. For low shear rates flow reversal can be seen as the director realigns with the flow direction, whereas for high shear rates the director reorientation occurs simultaneously across the gap. Experimentally, this inhomogeneous flow is predicted to be observed in flow reversal experiments in LCPs.

Data on the mixing of non-Newtonian fluids by a Rushton turbine in a cylindrical tank.

PubMed

Khapre, Akhilesh; Munshi, Basudeb

2016-09-01

The paper focuses on the data collected from the mixing of shear thinning non-Newtonian fluids in a cylindrical tank by a Rushton turbine. The data presented are obtained by using Computational Fluid Dynamics (CFD) simulation of fluid flow field in the entire tank volume. The CFD validation data for this study is reported in the research article 'Numerical investigation of hydrodynamic behavior of shear thinning fluids in stirred tank' (Khapre and Munshi, 2015) [1]. The tracer injection method is used for the prediction of mixing time and mixing efficiency of a Rushton turbine impeller.

Effect of Carreau-Yasuda rheological parameters on subcritical Lapwood convection in horizontal porous cavity saturated by shear-thinning fluid

NASA Astrophysics Data System (ADS)

Khechiba, Khaled; Mamou, Mahmoud; Hachemi, Madjid; Delenda, Nassim; Rebhi, Redha

2017-06-01

The present study is focused on Lapwood convection in isotropic porous media saturated with non-Newtonian shear thinning fluid. The non-Newtonian rheological behavior of the fluid is modeled using the general viscosity model of Carreau-Yasuda. The convection configuration consists of a shallow porous cavity with a finite aspect ratio and subject to a vertical constant heat flux, whereas the vertical walls are maintained impermeable and adiabatic. An approximate analytical solution is developed on the basis of the parallel flow assumption, and numerical solutions are obtained by solving the full governing equations. The Darcy model with the Boussinesq approximation and energy transport equations are solved numerically using a finite difference method. The results are obtained in terms of the Nusselt number and the flow fields as functions of the governing parameters. A good agreement is obtained between the analytical approximation and the numerical solution of the full governing equations. The effects of the rheological parameters of the Carreau-Yasuda fluid and Rayleigh number on the onset of subcritical convection thresholds are demonstrated. Regardless of the aspect ratio of the enclosure and thermal boundary condition type, the subcritical convective flows are seen to occur below the onset of stationary convection. Correlations are proposed to estimate the subcritical Rayleigh number for the onset of finite amplitude convection as a function of the fluid rheological parameters. Linear stability of the convective motion, predicted by the parallel flow approximation, is studied, and the onset of Hopf bifurcation, from steady convective flow to oscillatory behavior, is found to depend strongly on the rheological parameters. In general, Hopf bifurcation is triggered earlier as the fluid becomes more and more shear-thinning.

Numerical simulations of stick-slip in fluid saturated granular fault gouge

NASA Astrophysics Data System (ADS)

Dorostkar, O.; Johnson, P. A.; Guyer, R. A.; Marone, C.; Carmeliet, J.

2016-12-01

Fluids play a key role in determining the frictional strength and stability of faults. For example, fluid flow and fluid-solid interaction in fault gouge can trigger seismicity, alter earthquake nucleation properties and cause fault zone weakening. We present results of 3D numerical simulations of stick-slip behavior in dry and saturated granular fault gouge. In the saturated case, the gouge is fully saturated and drainage is possible through the boundaries. We model the solid phase (particles) with the discrete element method (DEM) while the fluid is described by the Navier-Stokes equations and solved by computational fluid dynamics (CFD). In our model, granular gouge is sheared between two rough plates under boundary conditions of constant normal stress and constant shearing velocity at the layer boundaries. A phase-space study including shearing velocity and normal stress is taken to identify the conditions for stick-slip regime. We analyzed slip events for dry and saturated cases to determine shear stress drop, released kinetic energy and compaction. The presence of fluid tends to cause larger slip events. We observe a close correlation between the kinetic energy of the particles and of the fluid. In short, during slip, fluid flow induced by the failure and compaction of the granular system, mobilizes the particles, which increases their kinetic energy, leading to greater slip. We further observe that the solid-fluid interaction forces are equal or larger than the solid-solid interaction forces during the slip event, indicating the important influence of the fluid on the granular system. Our simulations can explain the behaviors observed in experimental studies and we are working to apply our results to tectonic faults.

Flow accelerated organic coating degradation

NASA Astrophysics Data System (ADS)

Zhou, Qixin

Applying organic coatings is a common and the most cost effective way to protect metallic objects and structures from corrosion. Water entry into coating-metal interface is usually the main cause for the deterioration of organic coatings, which leads to coating delamination and underfilm corrosion. Recently, flowing fluids over sample surface have received attention due to their capability to accelerate material degradation. A plethora of works has focused on the flow induced metal corrosion, while few studies have investigated the flow accelerated organic coating degradation. Flowing fluids above coating surface affect corrosion by enhancing the water transport and abrading the surface due to fluid shear. Hence, it is of great importance to understand the influence of flowing fluids on the degradation of corrosion protective organic coatings. In this study, a pigmented marine coating and several clear coatings were exposed to the laminar flow and stationary immersion. The laminar flow was pressure driven and confined in a flow channel. A 3.5 wt% sodium chloride solution and pure water was employed as the working fluid with a variety of flow rates. The corrosion protective properties of organic coatings were monitored inline by Electrochemical Impedance Spectroscopy (EIS) measurement. Equivalent circuit models were employed to interpret the EIS spectra. The time evolution of coating resistance and capacitance obtained from the model was studied to demonstrate the coating degradation. Thickness, gloss, and other topography characterizations were conducted to facilitate the assessment of the corrosion. The working fluids were characterized by Fourier Transform Infrared Spectrometer (FTIR) and conductivity measurement. The influence of flow rate, fluid shear, fluid composition, and other effects in the coating degradation were investigated. We conclude that flowing fluid on the coating surface accelerates the transport of water, oxygen, and ions into the coating, as well as promotes the migration of coating materials from the coating into the working fluid, where coatings experience more severe deterioration in their barrier property under flowing conditions. Pure water has shown to be a much more aggressive working fluid than electrolyte solutions. The flowing fluid over the coating surface could be used as an effective acceleration method.

The effects of spatial inhomogeneities on flow through the endothelial surface layer.

PubMed

Leiderman, Karin M; Miller, Laura A; Fogelson, Aaron L

2008-05-21

Flow through the endothelial surface layer (the glycocalyx and adsorbed plasma proteins) plays an important but poorly understood role in cell signaling through a process known as mechanotransduction. Characterizing the flow rates and shear stresses throughout this layer is critical for understanding how flow-induced ionic currents, deformations of transmembrane proteins, and the convection of extracellular molecules signal biochemical events within the cell, including cytoskeletal rearrangements, gene activation, and the release of vasodilators. Previous mathematical models of flow through the endothelial surface layer are based upon the assumptions that the layer is of constant hydraulic permeability and constant height. These models also assume that the layer is continuous across the endothelium and that the layer extends into only a small portion of the vessel lumen. Results of these models predict that fluid shear stress is dissipated through the surface layer and is thus negligible near endothelial cell membranes. In this paper, such assumptions are removed, and the resultant flow rates and shear stresses through the layer are described. The endothelial surface layer is modeled as clumps of a Brinkman medium immersed in a Newtonian fluid. The width and spacing of each clump, hydraulic permeability, and fraction of the vessel lumen occupied by the layer are varied. The two-dimensional Navier-Stokes equations with an additional Brinkman resistance term are solved using a projection method. Several fluid shear stress transitions in which the stress at the membrane shifts from low to high values are described. These transitions could be significant to cell signaling since the endothelial surface layer is likely dynamic in its composition, density, and height.

Measurement of Giardia lamblia adhesion force using an integrated microfluidic assay.

PubMed

Lu, Ling; Zheng, Guo-Xia; Yang, Yu-Suo; Feng, Cheng-Yu; Liu, Fang-Fang; Wang, Yun-Hua

2017-02-01

The mechanisms how Giardias attach to the intestinal epithelium remain unclear. None of the methods currently being used to measure the attachment force could provide a continuous nutrition supply and a micro-aerobic atmosphere to the Giardia. Besides, they are all labor-intensive. In the present research, a microfluidic method based on electric circuit analogy was developed. The input fluid flowed through the inlet channel with different lengths and was distributed in four assay chambers. Shear force gradients were generated in chambers, too. This allowed an easy control of fluids and the shear forces. Most importantly, the shear stress large enough to detach Giardia could be generated in laminar flow regime. Moreover, analysis could be accomplished in one single test. By applying inlet flow rates of 30, 60, and 120 μL ml -1 , shear force gradients ranging from 19.47 to 60.50 Pa were generated. The adhesion forces of trophozoites were analyzed and the EC 50 of the force that caused 50% trophozoites detachment was calculated as 36.60 Pa. This paper presents a novel method for measurement of Giardia adhesion force. Graphical Abstract Measurement of Giardia adhesion force. Various of flow rates were applied to generate different shear forces and Giardia trophozoites remaining attached were counted (a-c). The percentages of attachment vs shear stress were plotted and the EC 50 of adhesion force was calculated (d).

Anisotropic dispersion and attenuation due to wave-induced fluid flow: Quasi-static finite element modeling in poroelastic solids

NASA Astrophysics Data System (ADS)

Wenzlau, F.; Altmann, J. B.; Müller, T. M.

2010-07-01

Heterogeneous porous media such as hydrocarbon reservoir rocks are effectively described as anisotropic viscoelastic solids. They show characteristic velocity dispersion and attenuation of seismic waves within a broad frequency band, and an explanation for this observation is the mechanism of wave-induced pore fluid flow. Various theoretical models quantify dispersion and attenuation of normal incident compressional waves in finely layered porous media. Similar models of shear wave attenuation are not known, nor do general theories exist to predict wave-induced fluid flow effects in media with a more complex distribution of medium heterogeneities. By using finite element simulations of poroelastic relaxation, the total frequency-dependent complex stiffness tensor can be computed for a porous medium with arbitrary internal heterogeneity. From the stiffness tensor, velocity dispersion and frequency-dependent attenuation are derived for compressional and shear waves as a function of the angle of incidence. We apply our approach to the case of layered media and to that of an ellipsoidal poroelastic inclusion. In the case of the ellipsoidal inclusion, compressional and shear wave modes show significant attenuation, and the characteristic frequency dependence of the effect is governed by the spatiotemporal scale of the pore fluid pressure relaxation. In our anisotropic examples, the angle dependence of the attenuation is stronger than that of the velocity dispersion. It becomes clear that the spatial attenuation patterns show specific characteristics of wave-induced fluid flow, implying that anisotropic attenuation measurements may contribute to the inversion of fluid transport properties in heterogeneous porous media.

Effects of sedimenting particles on the turbulence structure in a horizontal channel flow

NASA Astrophysics Data System (ADS)

Tay, Godwin F. K.; Kuhn, David C. S.; Tachie, Mark F.

2015-02-01

This work presents the results of experiments conducted in a horizontal channel to characterize low Reynolds number turbulent flows in the presence of small solid particles. The particle diameter relative to the integral length scale, dp/Λx, is approximately 0.02. Particles and fluid turbulence characteristics are measured for three average solid volume fractions of approximately ϕv = 2.0 × 10-4, 4.0 × 10-4, and 8.0 × 10-4 under conditions where the particle number density is evolving due to deposition. The results indicate that the mean slip between particles and the fluid is important only close to the wall. Away from the wall, the particles and unladen fluid mean velocities are similar. Differences between particles and the unladen fluid statistics are more pronounced in the wall-normal velocity fluctuations than the streamwise velocity fluctuations and Reynolds shear stress due to the stronger effect of the gravitational force in the wall-normal direction. The fluid turbulent intensities show no dependency on loading, but the peak Reynolds shear stress is significantly reduced. A quadrant decomposition of the Reynolds shear stress revealed a corresponding reduction in the ejections and sweeps for the laden flow in comparison with the unladen flow. Swirling strength and vorticity root-mean-square fluctuations decayed due to the damping effect of particles. The influence of particles on the turbulence structure was examined using two-point correlations of the velocity fluctuations and swirling strength, where it was demonstrated that the wall structures are attached eddies which are more extensive (much larger) in the particle-laden flow compared to the unladen flow.

Extensional Rheology Experiment Developed to Investigate the Rheology of Dilute Polymer Solutions in Microgravity

NASA Technical Reports Server (NTRS)

Logsdon, Kirk A.

2001-01-01

A fundamental characteristic of fluid is viscosity; that is, the fluid resists forces that cause it to flow. This characteristic, or parameter, is used by manufacturers and end-users to describe the physical properties of a specific material so that they know what to expect when a material, such as a polymer, is processed through an extruder, a film blower, or a fiber-spinning apparatus. Normally, researchers will report a shear viscosity that depends on the rate of an imposed shearing flow. Although this type of characterization is sufficient for some processes, simple shearing experiments do not provide a complete picture of what a processor may expect for all materials. Extensional stretching flows are common in many polymer-processing operations such as extrusion, blow molding, and fiber spinning. Therefore, knowledge of the complete rheological (ability to flow and be deformed) properties of the polymeric fluid being processed is required to accurately predict and account for the flow behavior. In addition, if numerical simulations are ever able to serve as a priori design tools for optimizing polymer processing operations such as those described above, an accurate knowledge of the extensional viscosity of a polymer system and its variation with temperature, concentration, molecular weight, and strain rate is critical.

The Role of Grain Dynamics in the Onset of Sediment Transport

NASA Astrophysics Data System (ADS)

Clark, A., IV; Shattuck, M. D.; Ouellette, N. T.; O'Hern, C.

2016-12-01

Despite decades of research, the grain-scale mechanisms that control the onset of sediment transport are still not well understood. A large collection of data, known as the Shields curve, shows that Θ c, which is the minimum dimensionless shear stress at the bed for grains to move, is primarily a function of the shear Reynolds number Re*. To understand this collapse, it is typically assumed that the onset of grain motion is determined by the conditions at which fluid forces violate static equilibrium for surface grains. Re* compares the grain size to the size of the viscous sublayer in the fluid flow, so the relevant fluid lift and drag forces vary with Re*. A complimentary approach, which remains relatively unexplored, is to ask instead when mobilized grains can stop. In this case, Re* is the ratio of two important time scales related to grain motion: (1) the time for a grain to equilibrate to the fluid flow and (2) the time for the shear stress to accelerate a grain over the characteristic bed roughness. Thus, Re* controls whether grains are accelerated significantly between collisions with the bed. To test how this effect relates to the Shields curve, we perform simulations of granular beds sheared by a model fluid flow, where Re* is varied only through the fluid-grain coupling, which alters the grain dynamics. We find good qualitative agreement with the Shields curve, and the quantitative discrepancies are consistent with lift forces calculations at varying Re*. Our results suggest that the onset of sediment transport may be better described as when mobile grains are able to stop, which varies significantly with Re*, and theoretical descriptions that account for this effect may be more successful than those that consider only static equilibrium.

Design of a microfluidic system for red blood cell aggregation investigation.

PubMed

Mehri, R; Mavriplis, C; Fenech, M

2014-06-01

The purpose of this paper is to design a microfluidic apparatus capable of providing controlled flow conditions suitable for red blood cell (RBC) aggregation analysis. The linear velocity engendered from the controlled flow provides constant shear rates used to qualitatively analyze RBC aggregates. The design of the apparatus is based on numerical and experimental work. The numerical work consists of 3D numerical simulations performed using a research computational fluid dynamics (CFD) solver, Nek5000, while the experiments are conducted using a microparticle image velocimetry system. A Newtonian model is tested numerically and experimentally, then blood is tested experimentally under several conditions (hematocrit, shear rate, and fluid suspension) to be compared to the simulation results. We find that using a velocity ratio of 4 between the two Newtonian fluids, the layer corresponding to blood expands to fill 35% of the channel thickness where the constant shear rate is achieved. For blood experiments, the velocity profile in the blood layer is approximately linear, resulting in the desired controlled conditions for the study of RBC aggregation under several flow scenarios.

Microstructural Rearrangements and their Rheological Implications in a Model Thixotropic Elastoviscoplastic Fluid

NASA Astrophysics Data System (ADS)

Jamali, Safa; McKinley, Gareth H.; Armstrong, Robert C.

2017-01-01

We identify the sequence of microstructural changes that characterize the evolution of an attractive particulate gel under flow and discuss their implications on macroscopic rheology. Dissipative particle dynamics is used to monitor shear-driven evolution of a fabric tensor constructed from the ensemble spatial configuration of individual attractive constituents within the gel. By decomposing this tensor into isotropic and nonisotropic components we show that the average coordination number correlates directly with the flow curve of the shear stress versus shear rate, consistent with theoretical predictions for attractive systems. We show that the evolution in nonisotropic local particle rearrangements are primarily responsible for stress overshoots (strain-hardening) at the inception of steady shear flow and also lead, at larger times and longer scales, to microstructural localization phenomena such as shear banding flow-induced structure formation in the vorticity direction.

Onset of sediment transport is a continuous transition driven by fluid shear and granular creep.

PubMed

Houssais, Morgane; Ortiz, Carlos P; Durian, Douglas J; Jerolmack, Douglas J

2015-03-09

Fluid-sheared granular transport sculpts landscapes and undermines infrastructure, yet predicting the onset of sediment transport remains notoriously unreliable. For almost a century, this onset has been treated as a discontinuous transition at which hydrodynamic forces overcome gravity-loaded grain-grain friction. Using a custom laminar-shear flume to image slow granular dynamics deep into the bed, here we find that the onset is instead a continuous transition from creeping to granular flow. This transition occurs inside the dense granular bed at a critical viscous number, similar to granular flows and colloidal suspensions and inconsistent with hydrodynamic frameworks. We propose a new phase diagram for sediment transport, where 'bed load' is a dense granular flow bounded by creep below and suspension above. Creep is characteristic of disordered solids and reminiscent of soil diffusion on hillslopes. Results provide new predictions for the onset and dynamics of sediment transport that challenge existing models.

Rapid expulsion of microswimmers by a vortical flow

DOE PAGES

Sokolov, Andrey; Aranson, Igor S.

2016-03-23

Interactions of microswimmers with their fluid environment are exceptionally complex. Macroscopic shear flow alters swimming trajectories in a highly nontrivial way and results in dramatic reduction of viscosity and heterogeneous bacterial distributions. Here we report on experimental and theoretical studies of rapid expulsion of microswimmers, such as motile bacteria, by a vortical flow created by a rotating microparticle. We observe a formation of a macroscopic depletion area in a high-shear region, in the vicinity of a microparticle. The rapid migration of bacteria from the shear-rich area is caused by a vortical structure of the flow rather than intrinsic random fluctuationsmore » of bacteria orientations, in stark contrast to planar shear flow. Our mathematical model reveals that expulsion is a combined effect of motility and alignment by a vortical flow. Our findings offer a novel approach for manipulation of motile microorganisms and shed light on bacteria-flow interactions.« less

Structural steady states and relaxation oscillations in a two-phase fluid under shear flow: Experiments and phenomenological model

NASA Astrophysics Data System (ADS)

Courbin, L.; Benayad, A.; Panizza, P.

2006-01-01

By means of several rheophysics techniques, we report on an extensive study of the couplings between flow and microstructures in a two-phase fluid made of lamellar (Lα) and sponge (L3) phases. Depending on the nature of the imposed dynamical parameter (stress or shear rate) and on the experimental conditions (brine salinity or temperature), we observe several different structural steady states consisting of either multilamellar droplets (with or without a long range order) or elongated (L3) phase domains. Two different astonishing phenomena, shear-induced phase inversion and relaxation oscillations, are observed. We show that (i) phase inversion is related to a shear-induced topological change between monodisperse multilamellar droplets and elongated structures and (ii) droplet size relaxation oscillations result from a shear-induced change of the surface tension between both coexisting (Lα) and (L3) phases. To explain these relaxation oscillations, we present a phenomenological model and compare its numerical predictions to our experimental results.

Buoyant miscible displacement flow of shear-thinning fluids: Experiments and Simulations

NASA Astrophysics Data System (ADS)

Ale Etrati Khosroshahi, Seyed Ali; Frigaard, Ian

2017-11-01

We study displacement flow of two miscible fluids with density and viscosity contrast in an inclined pipe. Our focus is mainly on displacements where transverse mixing is not significant and thus a two-layer, stratified flow develops. Our experiments are carried out in a long pipe, covering a wide range of flow-rates, inclination angles and viscosity ratios. Density and viscosity contrasts are achieved by adding Glycerol and Xanthan gum to water, respectively. At each angle, flow rate and viscosity ratio are varied and density contrast is fixed. We identify and map different flow regimes, instabilities and front dynamics based on Fr , Re / Frcosβ and viscosity ratio m. The problem is also studied numerically to get a better insight into the flow structure and shear-thinning effects. Numerical simulations are completed using OpenFOAM in both pipe and channel geometries and are compared against the experiments. Schlumberger, NSERC.

An upper bound on the particle-laden dependency of shear stresses at solid-fluid interfaces

NASA Astrophysics Data System (ADS)

Zohdi, T. I.

2018-03-01

In modern advanced manufacturing processes, such as three-dimensional printing of electronics, fine-scale particles are added to a base fluid yielding a modified fluid. For example, in three-dimensional printing, particle-functionalized inks are created by adding particles to freely flowing solvents forming a mixture, which is then deposited onto a surface, which upon curing yields desirable solid properties, such as thermal conductivity, electrical permittivity and magnetic permeability. However, wear at solid-fluid interfaces within the machinery walls that deliver such particle-laden fluids is typically attributed to the fluid-induced shear stresses, which increase with the volume fraction of added particles. The objective of this work is to develop a rigorous strict upper bound for the tolerable volume fraction of particles that can be added, while remaining below a given stress threshold at a fluid-solid interface. To illustrate the bound's utility, the expression is applied to a series of classical flow regimes.

Incompressible variable-density turbulence in an external acceleration field

DOE PAGES

Gat, Ilana; Matheou, Georgios; Chung, Daniel; ...

2017-08-24

Dynamics and mixing of a variable-density turbulent flow subject to an externally imposed acceleration field in the zero-Mach-number limit are studied in a series of direct numerical simulations. The flow configuration studied consists of alternating slabs of high- and low-density fluid in a triply periodic domain. Density ratios in the range ofmore » $$1.05\\leqslant R\\equiv \\unicode[STIX]{x1D70C}_{1}/\\unicode[STIX]{x1D70C}_{2}\\leqslant 10$$are investigated. The flow produces temporally evolving shear layers. A perpendicular density–pressure gradient is maintained in the mean as the flow evolves, with multi-scale baroclinic torques generated in the turbulent flow that ensues. For all density ratios studied, the simulations attain Reynolds numbers at the beginning of the fully developed turbulence regime. An empirical relation for the convection velocity predicts the observed entrainment-ratio and dominant mixed-fluid composition statistics. Two mixing-layer temporal evolution regimes are identified: an initial diffusion-dominated regime with a growth rate$${\\sim}t^{1/2}$$followed by a turbulence-dominated regime with a growth rate$${\\sim}t^{3}$$. In the turbulent regime, composition probability density functions within the shear layers exhibit a slightly tilted (‘non-marching’) hump, corresponding to the most probable mole fraction. In conclusion, the shear layers preferentially entrain low-density fluid by volume at all density ratios, which is reflected in the mixed-fluid composition.« less

Incompressible variable-density turbulence in an external acceleration field

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gat, Ilana; Matheou, Georgios; Chung, Daniel

Dynamics and mixing of a variable-density turbulent flow subject to an externally imposed acceleration field in the zero-Mach-number limit are studied in a series of direct numerical simulations. The flow configuration studied consists of alternating slabs of high- and low-density fluid in a triply periodic domain. Density ratios in the range ofmore » $$1.05\\leqslant R\\equiv \\unicode[STIX]{x1D70C}_{1}/\\unicode[STIX]{x1D70C}_{2}\\leqslant 10$$are investigated. The flow produces temporally evolving shear layers. A perpendicular density–pressure gradient is maintained in the mean as the flow evolves, with multi-scale baroclinic torques generated in the turbulent flow that ensues. For all density ratios studied, the simulations attain Reynolds numbers at the beginning of the fully developed turbulence regime. An empirical relation for the convection velocity predicts the observed entrainment-ratio and dominant mixed-fluid composition statistics. Two mixing-layer temporal evolution regimes are identified: an initial diffusion-dominated regime with a growth rate$${\\sim}t^{1/2}$$followed by a turbulence-dominated regime with a growth rate$${\\sim}t^{3}$$. In the turbulent regime, composition probability density functions within the shear layers exhibit a slightly tilted (‘non-marching’) hump, corresponding to the most probable mole fraction. In conclusion, the shear layers preferentially entrain low-density fluid by volume at all density ratios, which is reflected in the mixed-fluid composition.« less

Turbulent shear layers in confining channels

NASA Astrophysics Data System (ADS)

Benham, Graham P.; Castrejon-Pita, Alfonso A.; Hewitt, Ian J.; Please, Colin P.; Style, Rob W.; Bird, Paul A. D.

2018-06-01

We present a simple model for the development of shear layers between parallel flows in confining channels. Such flows are important across a wide range of topics from diffusers, nozzles and ducts to urban air flow and geophysical fluid dynamics. The model approximates the flow in the shear layer as a linear profile separating uniform-velocity streams. Both the channel geometry and wall drag affect the development of the flow. The model shows good agreement with both particle image velocimetry experiments and computational turbulence modelling. The simplicity and low computational cost of the model allows it to be used for benchmark predictions and design purposes, which we demonstrate by investigating optimal pressure recovery in diffusers with non-uniform inflow.

Numerical investigation of fluid mud motion using a three-dimensional hydrodynamic and two-dimensional fluid mud coupling model

NASA Astrophysics Data System (ADS)

Yang, Xiaochen; Zhang, Qinghe; Hao, Linnan

2015-03-01

A water-fluid mud coupling model is developed based on the unstructured grid finite volume coastal ocean model (FVCOM) to investigate the fluid mud motion. The hydrodynamics and sediment transport of the overlying water column are solved using the original three-dimensional ocean model. A horizontal two-dimensional fluid mud model is integrated into the FVCOM model to simulate the underlying fluid mud flow. The fluid mud interacts with the water column through the sediment flux, current, and shear stress. The friction factor between the fluid mud and the bed, which is traditionally determined empirically, is derived with the assumption that the vertical distribution of shear stress below the yield surface of fluid mud is identical to that of uniform laminar flow of Newtonian fluid in the open channel. The model is validated by experimental data and reasonable agreement is found. Compared with numerical cases with fixed friction factors, the results simulated with the derived friction factor exhibit the best agreement with the experiment, which demonstrates the necessity of the derivation of the friction factor.

Viscous-elastic dynamics of power-law fluids within an elastic cylinder

NASA Astrophysics Data System (ADS)

Boyko, Evgeniy; Bercovici, Moran; Gat, Amir D.

2017-07-01

In a wide range of applications, microfluidic channels are implemented in soft substrates. In such configurations, where fluidic inertia and compressibility are negligible, the propagation of fluids in channels is governed by a balance between fluid viscosity and elasticity of the surrounding solid. The viscous-elastic interactions between elastic substrates and non-Newtonian fluids are particularly of interest due to the dependence of viscosity on the state of the system. In this work, we study the fluid-structure interaction dynamics between an incompressible non-Newtonian fluid and a slender linearly elastic cylinder under the creeping flow regime. Considering power-law fluids and applying the thin shell approximation for the elastic cylinder, we obtain a nonhomogeneous p-Laplacian equation governing the viscous-elastic dynamics. We present exact solutions for the pressure and deformation fields for various initial and boundary conditions for both shear-thinning and shear-thickening fluids. We show that in contrast to Stokes' problem where a compactly supported front is obtained for shear-thickening fluids, here the role of viscosity is inversed and such fronts are obtained for shear-thinning fluids. Furthermore, we demonstrate that for the case of a step in inlet pressure, the propagation rate of the front has a tn/n +1 dependence on time (t ), suggesting the ability to indirectly measure the power-law index (n ) of shear-thinning liquids through measurements of elastic deformation.

Influence of viscosity modifying admixtures on the rheological behavior of cement and mortar pastes

NASA Astrophysics Data System (ADS)

Bouras, R.; Kaci, A.; Chaouche, M.

2012-03-01

The influence of Viscosity-modifying admixtures (VMA) dosage rate on the steady state rheological properties, including the yield stress, fluid consistency index and flow behaviour index, of cementitious materials is considered experimentally. The investigation is undertaken both at cement paste and mortar scales. It is found that the rheological behaviour of the material is in general dependent upon shear-rate interval considered. At sufficiently low shear-rates the materials exhibit shear-thinning. This behaviour is attributed to flow-induced defloculation of the solid particles and VMA polymer disentanglement and alignment. At relatively high shear-rates the pastes becomes shear-thickening, due to repulsive interactions among the solid particles. There is a qualitative difference between the influence of VMA dosage at cement and mortar scales: at cement scale we obtain a monotonic increase of the yield stress, while at mortar scale there exists an optimum VMA dosage for which the yield stress is a minimum. The flow behaviour index exhibit a maximum in the case of cement pastes and monotonically decreases in the case of mortars. On the other hand, the fluid consistency index presents a minimum for both cement pastes and mortars.

Radiating gravitational collapse with shearing motion and bulk viscosity

NASA Astrophysics Data System (ADS)

Chan, R.

2001-03-01

A model is proposed of a collapsing radiating star consisting of a shearing fluid with bulk viscosity undergoing radial heat flow with outgoing radiation. The pressure of the star, at the beginning of the collapse, is isotropic but due to the presence of the bulk viscosity the pressure becomes more and more anisotropic. The behavior of the density, pressure, mass, luminosity, the effective adiabatic index and the Kretschmann scalar is analyzed. Our work is compared to the case of a collapsing shearing fluid of a previous model, for a star with 6 Msun.

Viscoelastic effects on residual oil distribution in flows through pillared microchannels.

PubMed

De, S; Krishnan, P; van der Schaaf, J; Kuipers, J A M; Peters, E A J F; Padding, J T

2018-01-15

Multiphase flow through porous media is important in a number of industrial, natural and biological processes. One application is enhanced oil recovery (EOR), where a resident oil phase is displaced by a Newtonian or polymeric fluid. In EOR, the two-phase immiscible displacement through heterogonous porous media is usually governed by competing viscous and capillary forces, expressed through a Capillary number Ca, and viscosity ratio of the displacing and displaced fluid. However, when viscoelastic displacement fluids are used, elastic forces in the displacement fluid also become significant. It is hypothesized that elastic instabilities are responsible for enhanced oil recovery through an elastic microsweep mechanism. In this work, we use a simplified geometry in the form of a pillared microchannel. We analyze the trapped residual oil size distribution after displacement by a Newtonian fluid, a nearly inelastic shear thinning fluid, and viscoelastic polymers and surfactant solutions. We find that viscoelastic polymers and surfactant solutions can displace more oil compared to Newtonian fluids and nearly inelastic shear thinning polymers at similar Ca numbers. Beyond a critical Ca number, the size of residual oil blobs decreases significantly for viscoelastic fluids. This critical Ca number directly corresponds to flow rates where elastic instabilities occur in single phase flow, suggesting a close link between enhancement of oil recovery and appearance of elastic instabilities. Copyright © 2017 Elsevier Inc. All rights reserved.

Geometry-dependent viscosity reduction in sheared active fluids

NASA Astrophysics Data System (ADS)

Słomka, Jonasz; Dunkel, Jörn

2017-04-01

We investigate flow pattern formation and viscosity reduction mechanisms in active fluids by studying a generalized Navier-Stokes model that captures the experimentally observed bulk vortex dynamics in microbial suspensions. We present exact analytical solutions including stress-free vortex lattices and introduce a computational framework that allows the efficient treatment of higher-order shear boundary conditions. Large-scale parameter scans identify the conditions for spontaneous flow symmetry breaking, geometry-dependent viscosity reduction, and negative-viscosity states amenable to energy harvesting in confined suspensions. The theory uses only generic assumptions about the symmetries and long-wavelength structure of active stress tensors, suggesting that inviscid phases may be achievable in a broad class of nonequilibrium fluids by tuning confinement geometry and pattern scale selection.

Aspects of Turbulent / Non-Turbulent Interfaces

NASA Technical Reports Server (NTRS)

Bisset, D. K.; Hunt, J. C. R.; Rogers, M. M.; Koen, Dennis (Technical Monitor)

1999-01-01

A distinct boundary between turbulent and non-turbulent regions in a fluid of otherwise constant properties is found in many laboratory and engineering turbulent flows, including jets, mixing layers, boundary layers and wakes. Generally, the flow has mean shear in at least one direction within t he turbulent zone, but the non-turbulent zones have no shear (adjacent laminar shear is a different case, e.g. transition in a boundary layer). There may be purely passive differences between the turbulent and non-turbulent zones, e.g. small variations in temperature or scalar concentration, for which turbulent mixing is an important issue. The boundary has several major characteristics of interest for the present study. Firstly, the boundary advances into the non-turbulent fluid, or in other words, nonturbulent fluid is entrained. Secondly, the change in turbulence properties across the boundary is remarkably abrupt; strong turbulent motions come close to the nonturbulent fluid, promoting entrainment. Thirdly, the boundary is irregular with a continually changing convoluted shape, which produces statistical intermittency. Its shape is contorted at all scales of the turbulent motion.

Effect on Non-Newtonian Rheology on Mixing in Taylor-Couette Flow

NASA Astrophysics Data System (ADS)

Cagney, Neil; Balabani, Stavroula

2017-11-01

Mixing processes within many industry applications are strongly affected by the rheology of the working fluid. This is particularly relevant for pharmaceutical, food and waste treatment industries, where the working fluids are often strongly non-Newtonian, and significant variations in rheology between batches may occur. We approach the question of how rheology affects mixing by focussing on a the classical case of Taylor-Couette flow, which exhibits a number of instabilities and flow regimes as a function of Reynolds number. We examine Taylor-Couette flow generated for a range of aqueous solutions of xantham gum or corn starch, such that the rheology varies from shear-thinning to shear-thickening. For each case, we measure the power consumption using a torque meter and the flow field using high speed, time-resolved Particle-Image Velocimetry. The mixing characteristics are quantified using a number of Lagrangian and Eulerian approaches, including the coarse grained density method and vortex strength. By comparing these metrics to the power number, we discuss how the mixing efficiency (ratio of mixing effectiveness to power input) varies with the flow index of the fluid.

Finite element study of scaffold architecture design and culture conditions for tissue engineering.

PubMed

Olivares, Andy L; Marsal, Elia; Planell, Josep A; Lacroix, Damien

2009-10-01

Tissue engineering scaffolds provide temporary mechanical support for tissue regeneration and transfer global mechanical load to mechanical stimuli to cells through its architecture. In this study the interactions between scaffold pore morphology, mechanical stimuli developed at the cell microscopic level, and culture conditions applied at the macroscopic scale are studied on two regular scaffold structures. Gyroid and hexagonal scaffolds of 55% and 70% porosity were modeled in a finite element analysis and were submitted to an inlet fluid flow or compressive strain. A mechanoregulation theory based on scaffold shear strain and fluid shear stress was applied for determining the influence of each structures on the mechanical stimuli on initial conditions. Results indicate that the distribution of shear stress induced by fluid perfusion is very dependent on pore distribution within the scaffold. Gyroid architectures provide a better accessibility of the fluid than hexagonal structures. Based on the mechanoregulation theory, the differentiation process in these structures was more sensitive to inlet fluid flow than axial strain of the scaffold. This study provides a computational approach to determine the mechanical stimuli at the cellular level when cells are cultured in a bioreactor and to relate mechanical stimuli with cell differentiation.

Intracellular pH changes in human aortic smooth muscle cells in response to fluid shear stress

NASA Technical Reports Server (NTRS)

Stamatas, G. N.; Patrick, C. W. Jr; McIntire, L. V.

1997-01-01

The smooth muscle cell (SMC) layers of human arteries may be exposed to blood flow after endothelium denudation, for example, following balloon angioplasty treatment. These SMCs are also constantly subjected to pressure driven transmural fluid flow. Flow-induced shear stress can alter SMC growth and metabolism. Signal transduction mechanisms involved in these flow effects on SMCs are still poorly understood. In this work, the hypothesis that shear stress alters the intracellular pH (pHi) of SMC is examined. When exposed to venous and arterial levels of shear stress, human aortic smooth muscle cells (hASMC) undergo alkalinization. The alkalinization plateau persisted even after 20 min of cell exposure to flow. Addition of amiloride (10 micromoles) or its 5-(N-ethyl-N-isopropyl) analog (EIPA, 10 micromoles), both Na+/H+ exchanger inhibitors, attenuated intracellular alkalinization, suggesting the involvement of the Na+/H+ exchanger in this response. The same concentrations of these inhibitors did not show an effect on pHi of hASMCs in static culture. 4-Acetamido-4'-isothio-cyanatostilbene-2,2'-disulfonic acid (SITS, 1 mM), a Cl-/HCO3- exchange inhibitor, affected the pHi of hASMCs both in static and flow conditions. Our results suggest that flow may perturb the Na+/H+ exchanger leading to an alkalinization of hASMCs, a different response from the flow-induced acidification seen with endothelial cells at the same levels of shear stress. Understanding the flow-induced signal transduction pathways in the vascular cells is of great importance in the tissue engineering of vascular grafts. In the case of SMCs, the involvement of pHi changes in nitric oxide production and proliferation regulation highlights further the significance of such studies.

Flow characterization of a spinner flask for induced pluripotent stem cell culture application.

PubMed

Ismadi, Mohd-Zulhilmi; Gupta, Priyanka; Fouras, Andreas; Verma, Paul; Jadhav, Sameer; Bellare, Jayesh; Hourigan, Kerry

2014-01-01

We present detailed quantitative measurement analyses for flow in a spinner flask with spinning rates between 20 to 45 RPM, utilizing the optical velocimetry measurement technique of Particle Image Velocimetry (PIV). A partial section of the impeller was immersed in the working fluid to reduce the shear forces induced on the cells cultured on microcarriers. Higher rotational speeds improved the mixing effect in the medium at the expense of a higher shear environment. It was found that the mouse induced pluripotent stem (iPS) cells achieved the optimum number of cells over 7 days in 25 RPM suspension culture. This condition translates to 0.0984 Pa of maximum shear stress caused by the interaction of the fluid flow with the bottom surface. However, inverse cell growth was obtained at 28 RPM culture condition. Such a narrow margin demonstrated that mouse iPS cells cultured on microcarriers are very sensitive to mechanical forces. This study provides insight to biomechanical parameters, specifically the shear stress distribution, for a commercially available spinner flask over a wide range of Reynolds number.

Development and Implementation of Non-Newtonian Rheology Into the Generalized Fluid System Simulation Program (GFSSP)

NASA Technical Reports Server (NTRS)

DiSalvo, Roberto; Deaconu, Stelu; Majumdar, Alok

2006-01-01

One of the goals of this program was to develop the experimental and analytical/computational tools required to predict the flow of non-Newtonian fluids through the various system components of a propulsion system: pipes, valves, pumps etc. To achieve this goal we selected to augment the capabilities of NASA's Generalized Fluid System Simulation Program (GFSSP) software. GFSSP is a general-purpose computer program designed to calculate steady state and transient pressure and flow distributions in a complex fluid network. While the current version of the GFSSP code is able to handle various systems components the implicit assumption in the code is that the fluids in the system are Newtonian. To extend the capability of the code to non-Newtonian fluids, such as silica gelled fuels and oxidizers, modifications to the momentum equations of the code have been performed. We have successfully implemented in GFSSP flow equations for fluids with power law behavior. The implementation of the power law fluid behavior into the GFSSP code depends on knowledge of the two fluid coefficients, n and K. The determination of these parameters for the silica gels used in this program was performed experimentally. The n and K parameters for silica water gels were determined experimentally at CFDRC's Special Projects Laboratory, with a constant shear rate capillary viscometer. Batches of 8:1 (by weight) water-silica gel were mixed using CFDRC s 10-gallon gelled propellant mixer. Prior to testing the gel was allowed to rest in the rheometer tank for at least twelve hours to ensure that the delicate structure of the gel had sufficient time to reform. During the tests silica gel was pressure fed and discharged through stainless steel pipes ranging from 1", to 36", in length and three diameters; 0.0237", 0.032", and 0.047". The data collected in these tests included pressure at tube entrance and volumetric flowrate. From these data the uncorrected shear rate, shear stress, residence time, and viscosity were evaluated using formulae for non-Newtonian, power law fluids. The maximum shear rates (corrected for entrance effects) obtained in the rheometer with the current setup were in the 150,000 to 170,000sec- range. GFSSP simulations were performed with a flow circuit simulating the capillary rheometer and using Power Law gel viscosity coefficients from the experimental data. The agreement between the experimental data and the simulated flow curves was within +/-4% given quality entrance effect data.

Effective slip identities for viscous flow over arbitrary patterned surfaces

NASA Astrophysics Data System (ADS)

Kamrin, Ken; Six, Pierre

2012-11-01

For a variety of applications, most recently microfluidics, the ability to control fluid motions using surface texturing has been an area of ongoing interest. In this talk, we will develop several identities relating to the construction of effective slip boundary conditions for patterned surfaces. The effective slip measures the apparent slip of a fluid layer flowing over a patterned surface when viewing the flow far from the surface. In specific, shear flows of tall fluid layers over periodic surfaces (surfaces perturbed from a planar no-slip boundary by height and/or hydrophobicity fluctuations) are governed by an effective slip matrix that relates the vector of far-field shear stress (applied to the top of the fluid layer) to the effective slip velocity vector that emerges from the flow. Of particular note, we will demonstrate several general rules that describe the effective slip matrix: (1) that the effective slip matrix is always symmetric, (2) that the effective slip over any hydrophobically striped surface implies a family of related results for slip over other striped surfaces, and (3) that when height or hydrophobicity fluctuations are small, the slip matrix can be approximated directly using a simple formula derived from the surface pattern.

Self-organization in suspensions of end-functionalized semiflexible polymers under shear flow

NASA Astrophysics Data System (ADS)

Myung, Jin Suk; Winkler, Roland G.; Gompper, Gerhard

2015-12-01

The nonequilibrium dynamical behavior and structure formation of end-functionalized semiflexible polymer suspensions under flow are investigated by mesoscale hydrodynamic simulations. The hybrid simulation approach combines the multiparticle collision dynamics method for the fluid, which accounts for hydrodynamic interactions, with molecular dynamics simulations for the semiflexible polymers. In equilibrium, various kinds of scaffold-like network structures are observed, depending on polymer flexibility and end-attraction strength. We investigate the flow behavior of the polymer networks under shear and analyze their nonequilibrium structural and rheological properties. The scaffold structure breaks up and densified aggregates are formed at low shear rates, while the structural integrity is completely lost at high shear rates. We provide a detailed analysis of the shear- rate-dependent flow-induced structures. The studies provide a deeper understanding of the formation and deformation of network structures in complex materials.

Mixed convection boundary layer flow over a moving vertical flat plate in an external fluid flow with viscous dissipation effect.

PubMed

Bachok, Norfifah; Ishak, Anuar; Pop, Ioan

2013-01-01

The steady boundary layer flow of a viscous and incompressible fluid over a moving vertical flat plate in an external moving fluid with viscous dissipation is theoretically investigated. Using appropriate similarity variables, the governing system of partial differential equations is transformed into a system of ordinary (similarity) differential equations, which is then solved numerically using a Maple software. Results for the skin friction or shear stress coefficient, local Nusselt number, velocity and temperature profiles are presented for different values of the governing parameters. It is found that the set of the similarity equations has unique solutions, dual solutions or no solutions, depending on the values of the mixed convection parameter, the velocity ratio parameter and the Eckert number. The Eckert number significantly affects the surface shear stress as well as the heat transfer rate at the surface.

Analytical modeling for heat transfer in sheared flows of nanofluids.

PubMed

Ferrari, Claudio; Kaoui, Badr; L'vov, Victor S; Procaccia, Itamar; Rudenko, Oleksii; ten Thije Boonkkamp, J H M; Toschi, Federico

2012-07-01

We developed a model for the enhancement of the heat flux by spherical and elongated nanoparticles in sheared laminar flows of nanofluids. Besides the heat flux carried by the nanoparticles, the model accounts for the contribution of their rotation to the heat flux inside and outside the particles. The rotation of the nanoparticles has a twofold effect: it induces a fluid advection around the particle and it strongly influences the statistical distribution of particle orientations. These dynamical effects, which were not included in existing thermal models, are responsible for changing the thermal properties of flowing fluids as compared to quiescent fluids. The proposed model is strongly supported by extensive numerical simulations, demonstrating a potential increase of the heat flux far beyond the Maxwell-Garnett limit for the spherical nanoparticles. The road ahead, which should lead toward robust predictive models of heat flux enhancement, is discussed.

Fluid shear stress activates YAP1 to promote cancer cell motility

NASA Astrophysics Data System (ADS)

Lee, Hyun Jung; Diaz, Miguel F.; Price, Katherine M.; Ozuna, Joyce A.; Zhang, Songlin; Sevick-Muraca, Eva M.; Hagan, John P.; Wenzel, Pamela L.

2017-01-01

Mechanical stress is pervasive in egress routes of malignancy, yet the intrinsic effects of force on tumour cells remain poorly understood. Here, we demonstrate that frictional force characteristic of flow in the lymphatics stimulates YAP1 to drive cancer cell migration; whereas intensities of fluid wall shear stress (WSS) typical of venous or arterial flow inhibit taxis. YAP1, but not TAZ, is strictly required for WSS-enhanced cell movement, as blockade of YAP1, TEAD1-4 or the YAP1-TEAD interaction reduces cellular velocity to levels observed without flow. Silencing of TEAD phenocopies loss of YAP1, implicating transcriptional transactivation function in mediating force-enhanced cell migration. WSS dictates expression of a network of YAP1 effectors with executive roles in invasion, chemotaxis and adhesion downstream of the ROCK-LIMK-cofilin signalling axis. Altogether, these data implicate YAP1 as a fluid mechanosensor that functions to regulate genes that promote metastasis.

The role of chemical processes and brittle deformation during shear zone formation and its potential geophysical implications

NASA Astrophysics Data System (ADS)

Goncalves, Philippe; Leydier, Thomas; Mahan, Kevin; Albaric, Julie; Trap, Pierre; Marquer, Didier

2017-04-01

Ductile shear zones in the middle and lower continental crust are the locus of interactions between mechanical and chemical processes. Chemical processes encompass metamorphic reactions, fluid-rock interactions, fluid flow and chemical mass-transfer. Studying these processes at the grain scale, and even the atom scale, on exposed inactive shear zones can give insights into large-scale geodynamics phenomena (e.g. crustal growth and mountain building through the reconstruction of P-T-t-D-Ɛ evolutionary paths. However, other major issues in earth sciences can be tackled through these studies as well. For instance, the mechanism of fluid flow and mass transfer in the deep crust where permeability should be small and transient is still largely debated. Studying exhumed inactive shear zones can also help to interpret several new geophysical observations like (1) the origin of tremor and very low frequency earthquakes observed in the ductile middle and lower crust, (2) mechanisms for generating slow slip events and (3) the physical origin of puzzling crustal anisotropy observed in major active crustal shear zones. In this contribution, we present a collection of data (deformation, petrology, geochemistry, microtexture) obtained on various shear zones from the Alps that were active within the viscous regime (T > 450°C). Our observations show that the development of a shear zone, from its nucleation to its growth and propagation, is not only governed by ductile deformation coeval with reactions but also involves brittle deformation. Although brittle deformation is a very short-lived phenomenon, our petrological and textural observations show that brittle failure is also associated with fluid flow, mass transfer, metasomatic reactions and recrystallization. We speculate that the fluids and the associated mineralogical changes involved during this brittle failure in the ductile crust might play a role in earthquake / tremor triggering below the brittle - ductile transition. Furthermore, the occurrence of micro-fracturing in the ductile crust must have an influence on elastic wave propagation. While in the upper crust, fractures are believed to be the primary contributor to seismic anisotropy, at high pressure, the intrinsic rock Vp and Vs velocities are largely a function of the shape and crystallographic preferred orientation of minerals. However, if microfracturing is involved during ductile deformation, it may have a stronger influence on seismic properties (velocity and anisotropy) than the SPO and CPO of the main mineral phases, particularly if the microfractures are preferentially oriented. Thus, in major active ductile shear zones, like the Main Himalayan Thrust, the speculated transient but pervasive micro-fracturing during ongoing ductile deformation should be considered when interpreting seismic anisotropy. Finding evidences for brittle deformation, and associated fluid flow, in the ductile crust is a major challenge because many of these textural and mineralogical features tend to be obliterated by the pro-eminent ductile deformation. However, in order to fully understand the causes of some of these geophysical observations, the chemical and physical characterization of exhumed "fossil" ductile shear zones remains essential.

Simulating Fiber Ordering and Aggregation In Shear Flow Using Dissipative Particle Dynamics

NASA Astrophysics Data System (ADS)

Stimatze, Justin T.

We have developed a mesoscale simulation of fiber aggregation in shear flow using LAMMPS and its implementation of dissipative particle dynamics. Understanding fiber aggregation in shear flow and flow-induced microstructural fiber networks is critical to our interest in high-performance composite materials. Dissipative particle dynamics enables the consideration of hydrodynamic interactions between fibers through the coarse-grained simulation of the matrix fluid. Correctly simulating hydrodynamic interactions and accounting for fluid forces on the microstructure is required to correctly model the shear-induced aggregation process. We are able to determine stresses, viscosity, and fiber forces while simulating the evolution of a model fiber system undergoing shear flow. Fiber-fiber contact interactions are approximated by combinations of common pairwise forces, allowing the exploration of interaction-influenced fiber behaviors such as aggregation and bundling. We are then able to quantify aggregate structure and effective volume fraction for a range of relevant system and fiber-fiber interaction parameters. Our simulations have demonstrated several aggregate types dependent on system parameters such as shear rate, short-range attractive forces, and a resistance to relative rotation while in contact. A resistance to relative rotation at fiber-fiber contact points has been found to strongly contribute to an increased angle between neighboring aggregated fibers and therefore an increase in average aggregate volume fraction. This increase in aggregate volume fraction is strongly correlated with a significant enhancement of system viscosity, leading us to hypothesize that controlling the resistance to relative rotation during manufacturing processes is important when optimizing for desired composite material characteristics.

Measurement of the near-wall velocity profile for a nanofluid flow inside a microchannel

NASA Astrophysics Data System (ADS)

Kanjirakat, Anoop; Sadr, Reza

2015-11-01

Hydrodynamics and anomalous heat transfer enhancements have been reported in the past for colloidal suspensions of nano-sized particles dispersed in a fluid (nanofluids). However, such augmentations may manifest itself by study of fluid flow characteristics near in the wall region. Present experimental study reports near-wall velocity profile for nanofluids (silicon dioxide nanoparticles in water) measured inside a microchannel. An objective-based nano-Particle Image Velocimetry (nPIV) technique is used to measure fluid velocity within three visible depths, O(100nm), from the wall. The near-wall fluid velocity profile is estimated after implementing the required corrections for optical properties and effects caused by hindered Brownian motion, wall-particle interactions, and non-uniform exponential illumination on the measurement technique. The fluid velocities of nanofluids at each of the three visible depths are observed to be higher than that of the base fluid resulting in a higher shear rate in this region. The relative increase in shear rates for nanofluids is believed to be the result of the near-wall shear-induced particle migration along with the Brownian motion of the nanoparticles. This research is funded by NPRP grant # 08-574-2-239 from the Qatar National Research Fund (a member of Qatar Foundation).

Infiltration of meteoric fluids in an extensional detachment shear zone (Kettle dome, WA, USA): How quartz dynamic recrystallization relates to fluid-rock interaction

NASA Astrophysics Data System (ADS)

Quilichini, Antoine; Siebenaller, Luc; Nachlas, William O.; Teyssier, Christian; Vennemann, Torsten W.; Heizler, Matthew T.; Mulch, Andreas

2015-02-01

We document the interplay between meteoric fluid flow and deformation processes in quartzite-dominated lithologies within a ductile shear zone in the footwall of a Cordilleran extensional fault (Kettle detachment system, Washington, USA). Across 150 m of shear zone section, hydrogen isotope ratios (δD) from synkinematic muscovite fish are constant (δD ˜ -130‰) and consistent with a meteoric fluid source. Quartz-muscovite oxygen isotope thermometry indicates equilibrium fractionation temperatures of ˜365 ± 30 °C in the lower part of the section, where grain-scale quartz deformation was dominated by grain boundary migration recrystallization. In the upper part of the section, muscovite shows increasing intragrain compositional zoning, and quartz microstructures reflect bulging recrystallization, solution-precipitation, and microcracking that developed during progressive cooling and exhumation. The preserved microstructural characteristics and hydrogen isotope fingerprints of meteoric fluids developed over a short time interval as indicated by consistent mica 40Ar/39Ar ages ranging between 51 and 50 Ma over the entire section. Pervasive fluid flow became increasingly channelized during detachment activity, leading to microstructural heterogeneity and large shifts in quartz δ18O values on a meter scale. Ductile deformation ended when brittle motion on the detachment fault rapidly exhumed the mylonitic footwall.

TUBE SHEARING VALVE

DOEpatents

Wilner, L.B.

1960-05-24

Explosive operated valves can be used to join two or more containers in fluid flow relationship, one such container being a sealed reservoir. The valve is most simply disposed by mounting it on the reservoir so thst a tube extends from the interior of the reservoir through the valve body, terminating at the bottom of the bore in a closed end; other containers may be similarly connected or may be open connected, as desired. The piston of the valve has a cutting edge at its lower end which shears off the closed tube ends and a recess above the cutting edge to provide a flow channel. Intermixing of the fluid being transferred with the explosion gases is prevented by a copper ring at the top of the piston which is force fitted into the bore at the beginning of the stroke. Although designed to avoid backing up of the piston at pressures up to 10,000 psi in the transferred fluid, proper operation is independent of piston position, once the tube ends were sheared.

Fluid Structure Interaction Analysis on Sidewall Aneurysm Models

NASA Astrophysics Data System (ADS)

Hao, Qing

2016-11-01

Wall shear stress is considered as an important factor for cerebral aneurysm growth and rupture. The objective of present study is to evaluate wall shear stress in aneurysm sac and neck by a fluid-structure-interaction (FSI) model, which was developed and validated against the particle image velocimetry (PIV) data. In this FSI model, the flow characteristics in a straight tube with different asymmetric aneurysm sizes over a range of Reynolds numbers from 200 to 1600 were investigated. The FSI results agreed well with PIV data. It was found that at steady flow conditions, when Reynolds number above 700, one large recirculating vortex would be formed, occupying the entire aneurysm sac. The center of the vortex is located at region near to the distal neck. A pair of counter rotating vortices would however be formed at Reynolds number below 700. Wall shear stresses reached highest level at the distal neck of the aneurysmal sac. The vortex strength, in general, is stronger at higher Reynolds number. Fluid Structure Interaction Analysis on Sidewall Aneurysm Models.

Droplet breakup driven by shear thinning solutions in a microfluidic T-junction

NASA Astrophysics Data System (ADS)

Chiarello, Enrico; Gupta, Anupam; Mistura, Giampaolo; Sbragaglia, Mauro; Pierno, Matteo

2017-12-01

Droplet-based microfluidics turned out to be an efficient and adjustable platform for digital analysis, encapsulation of cells, drug formulation, and polymerase chain reaction. Typically, for most biomedical applications, the handling of complex, non-Newtonian fluids is involved, e.g., synovial and salivary fluids, collagen, and gel scaffolds. In this study, we investigate the problem of droplet formation occurring in a microfluidic T-shaped junction, when the continuous phase is made of shear thinning liquids. At first, we review in detail the breakup process, providing extensive, side-by-side comparisons between Newtonian and non-Newtonian liquids over unexplored ranges of flow conditions and viscous responses. The non-Newtonian liquid carrying the droplets is made of Xanthan solutions, a stiff, rodlike polysaccharide displaying a marked shear thinning rheology. By defining an effective Capillary number, a simple yet effective methodology is used to account for the shear-dependent viscous response occurring at the breakup. The droplet size can be predicted over a wide range of flow conditions simply by knowing the rheology of the bulk continuous phase. Experimental results are complemented with numerical simulations of purely shear thinning fluids using lattice Boltzmann models. The good agreement between the experimental and numerical data confirm the validity of the proposed rescaling with the effective Capillary number.

Theoretical study of the flow in a fluid damper containing high viscosity silicone oil: Effects of shear-thinning and viscoelasticity

NASA Astrophysics Data System (ADS)

Syrakos, Alexandros; Dimakopoulos, Yannis; Tsamopoulos, John

2018-03-01

The flow inside a fluid damper where a piston reciprocates sinusoidally inside an outer casing containing high-viscosity silicone oil is simulated using a finite volume method, at various excitation frequencies. The oil is modeled by the Carreau-Yasuda (CY) and Phan-Thien and Tanner (PTT) constitutive equations. Both models account for shear-thinning, but only the PTT model accounts for elasticity. The CY and other generalised Newtonian models have been previously used in theoretical studies of fluid dampers, but the present study is the first to perform full two-dimensional (axisymmetric) simulations employing a viscoelastic constitutive equation. It is found that the CY and PTT predictions are similar when the excitation frequency is low, but at medium and higher frequencies, the CY model fails to describe important phenomena that are predicted by the PTT model and observed in experimental studies found in the literature, such as the hysteresis of the force-displacement and force-velocity loops. Elastic effects are quantified by applying a decomposition of the damper force into elastic and viscous components, inspired from large amplitude oscillatory shear theory. The CY model also overestimates the damper force relative to the PTT model because it underpredicts the flow development length inside the piston-cylinder gap. It is thus concluded that (a) fluid elasticity must be accounted for and (b) theoretical approaches that rely on the assumption of one-dimensional flow in the piston-cylinder gap are of limited accuracy, even if they account for fluid viscoelasticity. The consequences of using lower-viscosity silicone oil are also briefly examined.

Wave Interactions and Fluid Flows

NASA Astrophysics Data System (ADS)

Craik, Alex D. D.

1988-07-01

This up-to-date and comprehensive account of theory and experiment on wave-interaction phenomena covers fluids both at rest and in their shear flows. It includes, on the one hand, water waves, internal waves, and their evolution, interaction, and associated wave-driven means flow and, on the other hand, phenomena on nonlinear hydrodynamic stability, especially those leading to the onset of turbulence. This study provide a particularly valuable bridge between these two similar, yet different, classes of phenomena. It will be of value to oceanographers, meteorologists, and those working in fluid mechanics, atmospheric and planetary physics, plasma physics, aeronautics, and geophysical and astrophysical fluid dynamics.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chang, Y.; Huang, L. H.; Yang, F. P. Y.

The present study analytically reinvestigates the two-dimensional lift-up problem for a rigid porous bed that was studied by Mei, Yeung, and Liu [“Lifting of a large object from a porous seabed,” J. Fluid Mech. 152, 203 (1985)]. Mei, Yeung, and Liu proposed a model that treats the bed as a rigid porous medium and performed relevant experiments. In their model, they assumed the gap flow comes from the periphery of the gap, and there is a shear layer in the porous medium; the flow in the gap is described by adhesion approximation [D. J. Acheson, Elementary Fluid Dynamics (Clarendon, Oxford,more » 1990), pp. 243-245.] and the pore flow by Darcy’s law, and the slip-flow condition proposed by Beavers and Joseph [“Boundary conditions at a naturally permeable wall,” J. Fluid Mech. 30, 197 (1967)] is applied to the bed interface. In this problem, however, the gap flow initially mainly comes from the porous bed, and the shear layer may not exist. Although later the shear effect becomes important, the empirical slip-flow condition might not physically respond to the shear effect, and the existence of the vertical velocity affects the situation so greatly that the slip-flow condition might not be appropriate. In contrast, the present study proposes a more general model for the problem, applying Stokes flow to the gap, the Brinkman equation to the porous medium, and Song and Huang’s [“Laminar poroelastic media flow,” J. Eng. Mech. 126, 358 (2000)] complete interfacial conditions to the bed interface. The exact solution to the problem is found and fits Mei’s experiments well. The breakout phenomenon is examined for different soil beds, mechanics that cannot be illustrated by Mei’s model are revealed, and the theoretical breakout times obtained using Mei’s model and our model are compared. The results show that the proposed model is more compatible with physics and provides results that are more precise.« less

Two-dimensional lift-up problem for a rigid porous bed

NASA Astrophysics Data System (ADS)

Chang, Y.; Huang, L. H.; Yang, F. P. Y.

2015-05-01

The present study analytically reinvestigates the two-dimensional lift-up problem for a rigid porous bed that was studied by Mei, Yeung, and Liu ["Lifting of a large object from a porous seabed," J. Fluid Mech. 152, 203 (1985)]. Mei, Yeung, and Liu proposed a model that treats the bed as a rigid porous medium and performed relevant experiments. In their model, they assumed the gap flow comes from the periphery of the gap, and there is a shear layer in the porous medium; the flow in the gap is described by adhesion approximation [D. J. Acheson, Elementary Fluid Dynamics (Clarendon, Oxford, 1990), pp. 243-245.] and the pore flow by Darcy's law, and the slip-flow condition proposed by Beavers and Joseph ["Boundary conditions at a naturally permeable wall," J. Fluid Mech. 30, 197 (1967)] is applied to the bed interface. In this problem, however, the gap flow initially mainly comes from the porous bed, and the shear layer may not exist. Although later the shear effect becomes important, the empirical slip-flow condition might not physically respond to the shear effect, and the existence of the vertical velocity affects the situation so greatly that the slip-flow condition might not be appropriate. In contrast, the present study proposes a more general model for the problem, applying Stokes flow to the gap, the Brinkman equation to the porous medium, and Song and Huang's ["Laminar poroelastic media flow," J. Eng. Mech. 126, 358 (2000)] complete interfacial conditions to the bed interface. The exact solution to the problem is found and fits Mei's experiments well. The breakout phenomenon is examined for different soil beds, mechanics that cannot be illustrated by Mei's model are revealed, and the theoretical breakout times obtained using Mei's model and our model are compared. The results show that the proposed model is more compatible with physics and provides results that are more precise.

On the stability analysis of sharply stratified shear flows

NASA Astrophysics Data System (ADS)

Churilov, Semyon

2018-05-01

When the stability of a sharply stratified shear flow is studied, the density profile is usually taken stepwise and a weak stratification between pycnoclines is neglected. As a consequence, in the instability domain of the flow two-sided neutral curves appear such that the waves corresponding to them are neutrally stable, whereas the neighboring waves on either side of the curve are unstable, in contrast with the classical result of Miles (J Fluid Mech 16:209-227, 1963) who proved that in stratified flows unstable oscillations can be only on one side of the neutral curve. In the paper, the contradiction is resolved and changes in the flow stability pattern under transition from a model stepwise to a continuous density profile are analyzed. On this basis, a simple self-consistent algorithm is proposed for studying the stability of sharply stratified shear flows with a continuous density variation and an arbitrary monotonic velocity profile without inflection points. Because our calculations and the algorithm are both based on the method of stability analysis (Churilov J Fluid Mech 539:25-55, 2005; ibid, 617, 301-326, 2008), which differs essentially from usually used, the paper starts with a brief review of the method and results obtained with it.

Fluid shear stress and tumor metastasis

PubMed Central

Huang, Qiong; Hu, Xingbin; He, Wanming; Zhao, Yang; Hao, Shihui; Wu, Qijing; Li, Shaowei; Zhang, Shuyi; Shi, Min

2018-01-01

The tumor microenvironment (TME) is a key factor regulating tumor cell invasion and metastasis. The effects of biochemical factors such as stromal cells, immune cells, and cytokines have been previously investigated. Owing to restrictions by the natural barrier between physical and biochemical disciplines, the role of physical factors in tumorigenesis is unclear. However, with the emergence of interdisciplinary mechanobiology and continuous advancements therein in the past 30 years, studies on the effect of physical properties such as hardness or shear stress on tumorigenesis and tumor progression are constantly renewing our understanding of mechanotransduction mechanisms. Shear stress, induced by liquid flow, is known to actively participate in proliferation, apoptosis, invasion, and metastasis of tumor cells. The present review discusses the progress and achievements in studies on tumor fluid microenvironment in recent years, especially fluid shear stress, on tumor metastasis, and presents directions for future study.

Experimental Reacting Hydrogen Shear Layer Data at High Subsonic Mach Number

NASA Technical Reports Server (NTRS)

Chang, C. T.; Marek, C. J.; Wey, C.; Wey, C. C.

1996-01-01

The flow in a planar shear layer of hydrogen reacting with hot air was measured with a two-component laser Doppler velocimeter (LDV) system, a schlieren system, and OH fluorescence imaging. It was compared with a similar air-to-air case without combustion. The high-speed stream's flow speed was about 390 m/s, or Mach 0.71, and the flow speed ratio was 0.34. The results showed that a shear layer with reaction grows faster than one without; both cases are within the range of data scatter presented by the established data base. The coupling between the streamwise and the cross-stream turbulence components inside the shear layers was low, and reaction only increased it slightly. However, the shear layer shifted laterally into the lower speed fuel stream, and a more organized pattern of Reynolds stress was present in the reaction shear layer, likely as a result of the formation of a larger scale structure associated with shear layer corrugation from heat release. Dynamic pressure measurements suggest that coherent flow perturbations existed inside the shear layer and that this flow became more chaotic as the flow advected downstream. Velocity and thermal variable values are listed in this report for a computational fluid dynamics (CFD) benchmark.

Velocity shear, turbulent saturation, and steep plasma gradients in the scrape-off layer of inner-wall limited tokamaks

DOE PAGES

Halpern, Federico D.; Ricci, Paolo

2016-12-19

The narrow power decay-length (λ q), recently found in the scrape-off layer (SOL) of inner wall limited (IWL) discharges in tokamaks, is studied using 3D, flux-driven, global two fluid turbulence simulations. The formation of the steep plasma profiles is found to arise due to radially sheared E×B poloidal flows. A complex interaction between sheared flows and parallel plasma currents outflowing into the sheath regulates the turbulent saturation, determining the transport levels. We quantify the effects of sheared flows, obtaining theoretical estimates in agreement with our non-linear simulations. As a result, analytical calculations suggest that the IWL λ q is roughlymore » equal to the turbulent correlation length.« less

Momentum balance and stresses in a suspension of spherical particles in a plane Couette flow

NASA Astrophysics Data System (ADS)

Rahmani, Mona; Hammouti, Abdelkader; Wachs, Anthony

2018-04-01

Non-Brownian suspension of monodisperse spherical particles, with volume fractions ranging between ϕ = 0.05 and 0.38 and particle Reynolds numbers ranging between Rep = 0.002 and 20, in plane Couette shear flows is investigated using three-dimensional particle-resolved numerical simulations. We examine the effects of volume fraction and particle Reynolds number on the macroscopic and microscopic stresses in the fluid phase. The effective viscosity of the suspension is in a good agreement with the previous empirical and experimental studies. At Rep = 20, however, the effective viscosity increases significantly compared to the lower particle Reynolds number simulations in the Stokes flow regime. Examining the stresses over the depth of the Couette gap reveals that this increase in wall shear stresses at high particle Reynolds numbers is mainly due to the significantly higher particle phase stress contributions. Next, we examine the momentum balance in the fluid and particle phase for different regimes to assess the significance of particle/particle interaction and fluid and particle inertia. At the highest particle Reynolds number and volume fraction, the particle inertia plays a dominant role in the momentum balance and the fluid inertia is non-negligible, while the short-lived contact forces are negligible compared to these effects. For all other regimes, the fluid inertia is negligible, but the particle inertia and contact forces are important in the momentum balance. Reynolds stresses originated from velocity fluctuations do not contribute significantly to the suspension stresses in any of the regimes we have studied, while the reduction in the shear-induced particle rotation can be a reason for higher wall shear stress at Rep = 20. Finally, we study the kinematics of particles, including their velocity fluctuations, rotation, and diffusion over the depth of the Couette gap. The particle diffusion coefficients in the cross flow direction exhibit an abrupt increase at Rep = 20.

Correlation between vortices and wall shear stress in a curved artery model under pulsatile flow conditions

NASA Astrophysics Data System (ADS)

Cox, Christopher; Plesniak, Michael W.

2017-11-01

One of the most physiologically relevant factors within the cardiovascular system is the wall shear stress. The wall shear stress affects endothelial cells via mechanotransduction and atherosclerotic regions are strongly correlated with curvature and branching in the human vasculature, where the shear stress is both oscillatory and multidirectional. Also, the combined effect of curvature and pulsatility in cardiovascular flows produces unsteady vortices. In this work, our goal is to assess the correlation between multiple vortex pairs and wall shear stress. To accomplish this, we use an in-house high-order flux reconstruction Navier-Stokes solver to simulate pulsatile flow of a Newtonian blood-analog fluid through a rigid 180° curved artery model. We use a physiologically relevant flow rate and generate results using both fully developed and uniform entrance conditions, the latter motivated by the fact that flow upstream to a curved artery may not be fully developed. Under these two inflow conditions, we characterize the evolution of various vortex pairs and their subsequent effect on several wall shear stress metrics. Supported by GW Center for Biomimetics and Bioinspired Engineering.

Etude hydromecanique d'une fracture en cisaillement sous contrainte normale constante

NASA Astrophysics Data System (ADS)

Lamontagne, Eric

This research study deals with the effects of shear direction and injection flow rate on the flow directional anisotropy for a given normal stress. It presents experimental works on hydromechanical shear behaviour of a fracture under constant normal stress conditions that permits the characterisation of the intrinsic hydraulic transmissivity in relation with the directional anisotropy of the roughness morphology on the fracture surfaces. Tests were performed on mortar replicas of a natural fracture so that the fracture roughness and void space geometry were kept the same for each test. The experimental work program was performed through direct shear tests on the fracture replicas in four shear directions under four constant normal stress levels. The application of the normal stress was followed by several injections of fluid under constant flow rate. Then, for each defined shear displacement, several injections of fluid were done at different flow rate but under constant flow rate. The test results show that: (1) for the whole shear tests, the global intrinsic transmissivity is included within an enveloping zone of about one order of size. The transmissivity curves within the enveloping zone has a particularity to increase about two orders of size in the first millimetre of shear displacement and subsequently stabilised rapidly; (2) the highest dilatancy do not correspond necessarily with the highest intrinsic transmissivity so that, the behaviour of the global intrinsic transmissivity is not directly proportional to the fracture dilatancy during shear; (3) after the peak shear stress, the divergence is more marked between the global intrinsic transmissivity curves at various flow rate; (4) after peak shear strength and the beginning of asperity degradation, the gradual passage to residual friction shear behaviour causes a directional flow anisotropy and a reorientation of the flow chenalisation direction sub perpendicularly to the shear direction; (5) the anisotropy is not to develop equally between the two sense in the perpendicular direction to shear direction. In order to characterise the dynamics of the flow pattern in the fracture, a statistical analysis of the surfaces morphology of the fracture and the casting of void space geometry were performed before and after shear. A statistical analysis of asperity heights, on the global scale of the fracture surfaces, permits to characterise the fracture morphology and put in evidence a large morphological structure on which are superposed smaller asperities of variable dimensions. This large dimension structure generate a higher level landing occupying more than half of the fracture area. The study of the surfaces morphology of the fracture, performed with the geostatistical mean asperity heights variogram by direction before shearing, show the presence of two entangled morphologic structure families (28 and 15 mm). This same study done after shearing shows that the asperity degradation seems associated with the reduction of the global intrinsic transmissivity of the fracture. Finally, the void spaces morphology evaluated by casting techniques, during the shear tests, has permitted to verify the contacts evolution with the increasing shear displacement and visualised flow chenalisation during fracture shearing.

Shear thinning effects on blood flow in straight and curved tubes

NASA Astrophysics Data System (ADS)

Cherry, Erica M.; Eaton, John K.

2013-07-01

Simulations were performed to determine the magnitude and types of errors one can expect when approximating blood in large arteries as a Newtonian fluid, particularly in the presence of secondary flows. This was accomplished by running steady simulations of blood flow in straight and curved tubes using both Newtonian and shear-thinning viscosity models. In the shear-thinning simulations, the viscosity was modeled as a shear rate-dependent function fit to experimental data. Simulations in straight tubes were modeled after physiologically relevant arterial flows, and flow parameters for the curved tube simulations were chosen to examine a variety of secondary flow strengths. The diameters ranged from 1 mm to 10 mm and the Reynolds numbers from 24 to 1500. Pressure and velocity data are reported for all simulations. In the straight tube simulations, the shear-thinning flows had flattened velocity profiles and higher pressure gradients compared to the Newtonian simulations. In the curved tube flows, the shear-thinning simulations tended to have blunted axial velocity profiles, decreased secondary flow strengths, and decreased axial vorticity compared to the Newtonian simulations. The cross-sectionally averaged pressure drops in the curved tubes were higher in the shear-thinning flows at low Reynolds number but lower at high Reynolds number. The maximum deviation in secondary flow magnitude averaged over the cross sectional area was 19% of the maximum secondary flow and the maximum deviation in axial vorticity was 25% of the maximum vorticity.

Effect of thermal noise on vesicles and capsules in shear flow.

PubMed

Abreu, David; Seifert, Udo

2012-07-01

We add thermal noise consistently to reduced models of undeformable vesicles and capsules in shear flow and derive analytically the corresponding stochastic equations of motion. We calculate the steady-state probability distribution function and construct the corresponding phase diagrams for the different dynamical regimes. For fluid vesicles, we predict that at small shear rates thermal fluctuations induce a tumbling motion for any viscosity contrast. For elastic capsules, due to thermal mixing, an intermittent regime appears in regions where deterministic models predict only pure tank treading or tumbling.

Optimizing Micromixer Surfaces To Deter Biofouling.

PubMed

Waters, James T; Liu, Ya; Li, Like; Balazs, Anna C

2018-03-07

Using computational modeling, we show that the dynamic interplay between a flowing fluid and the appropriately designed surface relief pattern can inhibit the fouling of the substrate. We specifically focus on surfaces that are decorated with three-dimensional (3D) chevron or sawtooth "micromixer" patterns and model the fouling agents (e.g., cells) as spherical microcapsules. The interaction between the imposed shear flow and the chevrons on the surface generates 3D vortices in the system. We pinpoint a range of shear rates where the forces from these vortices can rupture the bonds between the two mobile microcapsules near the surface. Notably, the patterned surface offers fewer points of attachment than a flat substrate, and the shear flows readily transport the separated capsules away from the layer. We contrast the performance of surfaces that encompass rectangular posts, chevrons, and asymmetric sawtooth patterns and thereby identify the geometric factors that cause the sawtooth structure to be most effective at disrupting the bonding between the capsules. By breaking up nascent clusters of contaminant cells, these 3D relief patterns can play a vital role in disrupting the biofouling of surfaces immersed in flowing fluids.

Using Computational Fluid Dynamics to Compare Shear Rate and Turbulence in the TIM-Automated Gastric Compartment With USP Apparatus II.

PubMed

Hopgood, Matthew; Reynolds, Gavin; Barker, Richard

2018-03-30

We use computational fluid dynamics to compare the shear rate and turbulence in an advanced in vitro gastric model (TIMagc) during its simulation of fasted state Migrating Motor Complex phases I and II, with the United States Pharmacopeia paddle dissolution apparatus II (USPII). A specific focus is placed on how shear rate in these apparatus affects erosion-based solid oral dosage forms. The study finds that tablet surface shear rates in TIMagc are strongly time dependant and fluctuate between 0.001 and 360 s -1 . In USPII, tablet surface shear rates are approximately constant for a given paddle speed and increase linearly from 9 s -1 to 36 s -1 as the paddle speed is increased from 25 to 100 rpm. A strong linear relationship is observed between tablet surface shear rate and tablet erosion rate in USPII, whereas TIMagc shows highly variable behavior. The flow regimes present in each apparatus are compared to in vivo predictions using Reynolds number analysis. Reynolds numbers for flow in TIMagc lie predominantly within the predicted in vivo bounds (0.01-30), whereas Reynolds numbers for flow in USPII lie above the predicted upper bound when operating with paddle speeds as low as 25 rpm (33). Copyright © 2018 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

Viscoelastic properties of the small intestinal and caecal contents of the chicken.

PubMed

Takahashi, T; Goto, M; Sakata, T

2004-06-01

We measured the coefficients of viscosity, shear rates and shear stresses of chicken small intestinal and caecal contents, including solid particles, using a tube-flow viscometer. The coefficients of viscosity of chicken small intestinal and caecal contents were correlated negatively with their shear rates, a characteristic typical of non-Newtonian fluids. The coefficient of viscosity of the small intestinal contents was lower than that of the caecal contents at a shear rate of 1 s(-1). Chicken caecal contents were more viscous than pig caecal contents. The exponential relationship between shear stress and shear rate showed that chicken small intestinal and caecal contents had an apparent Herschel-Bulkley fluid nature. These results indicate that solid particles, including uric acid crystals, are mainly responsible for the viscosity of the digesta in the chicken.

Onset of sediment transport is a continuous transition driven by fluid shear and granular creep

PubMed Central

Houssais, Morgane; Ortiz, Carlos P.; Durian, Douglas J.; Jerolmack, Douglas J.

2015-01-01

Fluid-sheared granular transport sculpts landscapes and undermines infrastructure, yet predicting the onset of sediment transport remains notoriously unreliable. For almost a century, this onset has been treated as a discontinuous transition at which hydrodynamic forces overcome gravity-loaded grain–grain friction. Using a custom laminar-shear flume to image slow granular dynamics deep into the bed, here we find that the onset is instead a continuous transition from creeping to granular flow. This transition occurs inside the dense granular bed at a critical viscous number, similar to granular flows and colloidal suspensions and inconsistent with hydrodynamic frameworks. We propose a new phase diagram for sediment transport, where ‘bed load’ is a dense granular flow bounded by creep below and suspension above. Creep is characteristic of disordered solids and reminiscent of soil diffusion on hillslopes. Results provide new predictions for the onset and dynamics of sediment transport that challenge existing models. PMID:25751296

Simultaneous imaging of blood flow dynamics and vascular remodelling during development.

PubMed

Ghaffari, Siavash; Leask, Richard L; Jones, Elizabeth A V

2015-12-01

Normal vascular development requires blood flow. Time-lapse imaging techniques have revolutionised our understanding of developmental biology, but measuring changes in blood flow dynamics has met with limited success. Ultrasound biomicroscopy and optical coherence tomography can concurrently image vascular structure and blood flow velocity, but these techniques lack the resolution to accurately calculate fluid forces such as shear stress. This is important because hemodynamic forces are biologically active and induce changes in the expression of genes important for vascular development. Regional variations in shear stress, rather than the overall level, control processes such as vessel enlargement and regression during vascular remodelling. We present a technique to concurrently visualise vascular remodelling and blood flow dynamics. We use an avian embryonic model and inject an endothelial-specific dye and fluorescent microspheres. The motion of the microspheres is captured with a high-speed camera and the velocity of the blood flow in and out of the region of interest is quantified by micro-particle image velocitymetry (µPIV). The vessel geometry and flow are used to numerically solve the flow physics with computational fluid dynamics (CFD). Using this technique, we can analyse changes in shear stress, pressure drops and blood flow velocities over a period of 10 to 16 h. We apply this to study the relationship between shear stress and chronic changes in vessel diameter during embryonic development, both in normal development and after TGFβ stimulation. This technique allows us to study the interaction of biomolecular and biomechanical signals during vascular remodelling using an in vivo developmental model. © 2015. Published by The Company of Biologists Ltd.

Geometric flow control of shear bands by suppression of viscous sliding

PubMed Central

Viswanathan, Koushik; Mahato, Anirban; Sundaram, Narayan K.; M'Saoubi, Rachid; Trumble, Kevin P.; Chandrasekar, Srinivasan

2016-01-01

Shear banding is a plastic flow instability with highly undesirable consequences for metals processing. While band characteristics have been well studied, general methods to control shear bands are presently lacking. Here, we use high-speed imaging and micro-marker analysis of flow in cutting to reveal the common fundamental mechanism underlying shear banding in metals. The flow unfolds in two distinct phases: an initiation phase followed by a viscous sliding phase in which most of the straining occurs. We show that the second sliding phase is well described by a simple model of two identical fluids being sheared across their interface. The equivalent shear band viscosity computed by fitting the model to experimental displacement profiles is very close in value to typical liquid metal viscosities. The observation of similar displacement profiles across different metals shows that specific microstructure details do not affect the second phase. This also suggests that the principal role of the initiation phase is to generate a weak interface that is susceptible to localized deformation. Importantly, by constraining the sliding phase, we demonstrate a material-agnostic method—passive geometric flow control—that effects complete band suppression in systems which otherwise fail via shear banding. PMID:27616920

Geometric flow control of shear bands by suppression of viscous sliding

NASA Astrophysics Data System (ADS)

Sagapuram, Dinakar; Viswanathan, Koushik; Mahato, Anirban; Sundaram, Narayan K.; M'Saoubi, Rachid; Trumble, Kevin P.; Chandrasekar, Srinivasan

2016-08-01

Shear banding is a plastic flow instability with highly undesirable consequences for metals processing. While band characteristics have been well studied, general methods to control shear bands are presently lacking. Here, we use high-speed imaging and micro-marker analysis of flow in cutting to reveal the common fundamental mechanism underlying shear banding in metals. The flow unfolds in two distinct phases: an initiation phase followed by a viscous sliding phase in which most of the straining occurs. We show that the second sliding phase is well described by a simple model of two identical fluids being sheared across their interface. The equivalent shear band viscosity computed by fitting the model to experimental displacement profiles is very close in value to typical liquid metal viscosities. The observation of similar displacement profiles across different metals shows that specific microstructure details do not affect the second phase. This also suggests that the principal role of the initiation phase is to generate a weak interface that is susceptible to localized deformation. Importantly, by constraining the sliding phase, we demonstrate a material-agnostic method-passive geometric flow control-that effects complete band suppression in systems which otherwise fail via shear banding.

Vortex Dynamics and Shear-Layer Instability in High-Intensity Cyclotrons.

PubMed

Cerfon, Antoine J

2016-04-29

We show that the space-charge dynamics of high-intensity beams in the plane perpendicular to the magnetic field in cyclotrons is described by the two-dimensional Euler equations for an incompressible fluid. This analogy with fluid dynamics gives a unified and intuitive framework to explain the beam spiraling and beam breakup behavior observed in experiments and in simulations. Specifically, we demonstrate that beam breakup is the result of a classical instability occurring in fluids subject to a sheared flow. We give scaling laws for the instability and predict the nonlinear evolution of beams subject to it. Our work suggests that cyclotrons may be uniquely suited for the experimental study of shear layers and vortex distributions that are not achievable in Penning-Malmberg traps.

Characterization of commercial magnetorheological fluids at high shear rate: influence of the gap

NASA Astrophysics Data System (ADS)

Golinelli, Nicola; Spaggiari, Andrea

2018-07-01

This paper reports the experimental tests on the behaviour of a commercial MR fluid at high shear rates and the effect of the gap. Three gaps were considered at multiple magnetic fields and shear rates. From an extended set of almost two hundred experimental flow curves, a set of parameters for the apparent viscosity are retrieved by using the Ostwald de Waele model for non-Newtonian fluids. It is possible to simplify the parameter correlation by making the following considerations: the consistency of the model depends only on the magnetic field, the flow index depends on the fluid type and the gap shows an important effect only at null or very low magnetic fields. This lead to a simple and useful model, especially in the design phase of a MR based product. During the off state, with no applied field, it is possible to use a standard viscous model. During the active state, with high magnetic field, a strong non-Newtonian nature becomes prevalent over the viscous one even at very high shear rate; the magnetic field dominates the apparent viscosity change, while the gap does not play any relevant role on the system behaviour. This simple assumption allows the designer to dimension the gap only considering the non-active state, as in standard viscous systems, and taking into account only the magnetic effect in the active state, where the gap does not change the proposed fluid model.

Fluid shear promotes chondrosarcoma cell invasion by activating matrix metalloproteinase 12 via IGF-2 and VEGF signaling pathways

PubMed Central

Wang, P; Chen, S-H; Hung, W-C; Paul, C; Zhu, F; Guan, P-P; Huso, DL; Kontrogianni-Konstantopoulos, A; Konstantopoulos, K

2015-01-01

Interstitial fluid flow in and around the tumor tissue is a physiologically relevant mechanical signal that regulates intracellular signaling pathways throughout the tumor. Yet, the effects of interstitial flow and associated fluid shear stress on the tumor cell function have been largely overlooked. Using in vitro bioengineering models in conjunction with molecular cell biology tools, we found that fluid shear (2 dyn/cm2) markedly upregulates matrix metalloproteinase 12 (MMP-12) expression and its activity in human chondrosarcoma cells. MMP-12 expression is induced in human chondrocytes during malignant transformation. However, the signaling pathway regulating MMP-12 expression and its potential role in human chondrosarcoma cell invasion and metastasis have yet to be delineated. We discovered that fluid shear stress induces the synthesis of insulin growth factor-2 (IGF-2) and vascular endothelial growth factor (VEGF) B and D, which in turn transactivate MMP-12 via PI3-K, p38 and JNK signaling pathways. IGF-2-, VEGF-B- or VEGF-D-stimulated chondrosarcoma cells display markedly higher migratory and invasive potentials in vitro, which are blocked by inhibiting MMP-12, PI3-K, p38 or JNK activity. Moreover, recombinant human MMP-12 or MMP-12 overexpression can potentiate chondrosarcoma cell invasion in vitro and the lung colonization in vivo. By reconstructing and delineating the signaling pathway regulating MMP-12 activation, potential therapeutic strategies that interfere with chondrosarcoma cell invasion may be identified. PMID:25435370

Fluid shear promotes chondrosarcoma cell invasion by activating matrix metalloproteinase 12 via IGF-2 and VEGF signaling pathways.

PubMed

Wang, P; Chen, S-H; Hung, W-C; Paul, C; Zhu, F; Guan, P-P; Huso, D L; Kontrogianni-Konstantopoulos, A; Konstantopoulos, K

2015-08-27

Interstitial fluid flow in and around the tumor tissue is a physiologically relevant mechanical signal that regulates intracellular signaling pathways throughout the tumor. Yet, the effects of interstitial flow and associated fluid shear stress on the tumor cell function have been largely overlooked. Using in vitro bioengineering models in conjunction with molecular cell biology tools, we found that fluid shear (2 dyn/cm(2)) markedly upregulates matrix metalloproteinase 12 (MMP-12) expression and its activity in human chondrosarcoma cells. MMP-12 expression is induced in human chondrocytes during malignant transformation. However, the signaling pathway regulating MMP-12 expression and its potential role in human chondrosarcoma cell invasion and metastasis have yet to be delineated. We discovered that fluid shear stress induces the synthesis of insulin growth factor-2 (IGF-2) and vascular endothelial growth factor (VEGF) B and D, which in turn transactivate MMP-12 via PI3-K, p38 and JNK signaling pathways. IGF-2-, VEGF-B- or VEGF-D-stimulated chondrosarcoma cells display markedly higher migratory and invasive potentials in vitro, which are blocked by inhibiting MMP-12, PI3-K, p38 or JNK activity. Moreover, recombinant human MMP-12 or MMP-12 overexpression can potentiate chondrosarcoma cell invasion in vitro and the lung colonization in vivo. By reconstructing and delineating the signaling pathway regulating MMP-12 activation, potential therapeutic strategies that interfere with chondrosarcoma cell invasion may be identified.

Modeling of the blood rheology in steady-state shear flows

DOE Office of Scientific and Technical Information (OSTI.GOV)

Apostolidis, Alex J.; Beris, Antony N., E-mail: beris@udel.edu

We undertake here a systematic study of the rheology of blood in steady-state shear flows. As blood is a complex fluid, the first question that we try to answer is whether, even in steady-state shear flows, we can model it as a rheologically simple fluid, i.e., we can describe its behavior through a constitutive model that involves only local kinematic quantities. Having answered that question positively, we then probe as to which non-Newtonian model best fits available shear stress vs shear-rate literature data. We show that under physiological conditions blood is typically viscoplastic, i.e., it exhibits a yield stress thatmore » acts as a minimum threshold for flow. We further show that the Casson model emerges naturally as the best approximation, at least for low and moderate shear-rates. We then develop systematically a parametric dependence of the rheological parameters entering the Casson model on key physiological quantities, such as the red blood cell volume fraction (hematocrit). For the yield stress, we base our description on its critical, percolation-originated nature. Thus, we first determine onset conditions, i.e., the critical threshold value that the hematocrit has to have in order for yield stress to appear. It is shown that this is a function of the concentration of a key red blood cell binding protein, fibrinogen. Then, we establish a parametric dependence as a function of the fibrinogen and the square of the difference of the hematocrit from its critical onset value. Similarly, we provide an expression for the Casson viscosity, in terms of the hematocrit and the temperature. A successful validation of the proposed formula is performed against additional experimental literature data. The proposed expression is anticipated to be useful not only for steady-state blood flow modeling but also as providing the starting point for transient shear, or more general flow modeling.« less

The effects of forcing on a single stream shear layer and its parent boundary layer

NASA Technical Reports Server (NTRS)

Haw, Richard C.; Foss, John F.

1990-01-01

Forcing and its effect on fluid flows has become an accepted tool in the study and control of flow systems. It has been used both as a diagnostic tool, to explore the development and interaction of coherent structures, and as a method of controlling the behavior of the flow. A number of forcing methods have been used in order to provide a perturbation to the flow; among these are the use of an oscillating trailing edge, acoustically driven slots, external acoustic forcing, and mechanical piston methods. The effect of a planar mechanical piston forcing on a single stream shear layer is presented; it can be noted that this is one of the lesser studied free shear layers. The single stream shear layer can be characterized by its primary flow velocity scale and the thickness of the separating boundary layer. The velocity scale is constant over the length of the flow field; theta (x) can be used as a width scale to characterize the unforced shear layer. In the case of the forced shear layer the velocity field is a function of phase time and definition of a width measure becomes somewhat problematic.

Receptor-mediated binding of IgE-sensitized rat basophilic leukemia cells to antigen-coated substrates under hydrodynamic flow.

PubMed Central

Tempelman, L A; Hammer, D A

1994-01-01

The physiological function of many cells is dependent on their ability to adhere via receptors to ligand-coated surfaces under fluid flow. We have developed a model experimental system to measure cell adhesion as a function of cell and surface chemistry and fluid flow. Using a parallel-plate flow chamber, we measured the binding of rat basophilic leukemia cells preincubated with anti-dinitrophenol IgE antibody to polyacrylamide gels covalently derivatized with 2,4-dinitrophenol. The rat basophilic leukemia cells' binding behavior is binary: cells are either adherent or continue to travel at their hydrodynamic velocity, and the transition between these two states is abrupt. The spatial location of adherent cells shows cells can adhere many cell diameters down the length of the gel, suggesting that adhesion is a probabilistic process. The majority of experiments were performed in the excess ligand limit in which adhesion depends strongly on the number of receptors but weakly on ligand density. Only 5-fold changes in IgE surface density or in shear rate were necessary to change adhesion from complete to indistinguishable from negative control. Adhesion showed a hyperbolic dependence on shear rate. By performing experiments with two IgE-antigen configurations in which the kinetic rates of receptor-ligand binding are different, we demonstrate that the forward rate of reaction of the receptor-ligand pair is more important than its thermodynamic affinity in the regulation of binding under hydrodynamic flow. In fact, adhesion increases with increasing receptor-ligand reaction rate or decreasing shear rate, and scales with a single dimensionless parameter which compares the relative rates of reaction to fluid shear. Images FIGURE 2 FIGURE 3 FIGURE 6 FIGURE 8 FIGURE 10 PMID:8038394

Local shear stress and its correlation with local volume fraction in concentrated non-Brownian suspensions: Lattice Boltzmann simulation

NASA Astrophysics Data System (ADS)

Lee, Young Ki; Ahn, Kyung Hyun; Lee, Seung Jong

2014-12-01

The local shear stress of non-Brownian suspensions was investigated using the lattice Boltzmann method coupled with the smoothed profile method. Previous studies have only focused on the bulk rheology of complex fluids because the local rheology of complex fluids was not accessible due to technical limitations. In this study, the local shear stress of two-dimensional solid particle suspensions in Couette flow was investigated with the method of planes to correlate non-Newtonian fluid behavior with the structural evolution of concentrated particle suspensions. Shear thickening was successfully captured for highly concentrated suspensions at high particle Reynolds number, and both the local rheology and local structure of the suspensions were analyzed. It was also found that the linear correlation between the local particle stress and local particle volume fraction was dramatically reduced during shear thickening. These results clearly show how the change in local structure of suspensions influences the local and bulk rheology of the suspensions.

Temperature Effect on Rheological Behavior of Silicone Oils. A Model for the Viscous Heating.

PubMed

Romano, Mario R; Cuomo, Francesca; Massarotti, Nicola; Mauro, Alessandro; Salahudeen, Mohamed; Costagliola, Ciro; Ambrosone, Luigi

2017-07-27

The rheological behavior of silicone oils, (CH 3 ) 3 SiO-[Si(CH 3 ) 2 O] n -Si(CH 3 ) 3 , and their mixtures is studied. Shear-stress measurements, in the temperature range of 293-313 K, reveal that this polymer family is a group of shear-thinning liquids with a yield stress below which no flow occurs. Experimental diagrams, i.e., shear stress versus shear rate, are satisfactorily described by the Casson fluid model over a wide range of shear rates. In order to monitor the effect of temperature on fluid properties, Casson's rheological model is reformulated using the fictitious shear rate, γ̇ f , and the infinite-shear viscosity, η ∞ , as constitutive parameters. Due to low intermolecular forces and high chain flexibility, γ̇ f varies very little when the temperature increases. For this reason, the apparent material viscosity depends on temperature only through η ∞ , which exponentially decreases until high shear rates are reached, and there is more alignment possible. Interestingly, the temperature sensitivity of this pseudoplastic behavior is the same for all of the silicone oils investigated; therefore, they can be classified according to their tendency to emulsify. Experimental results are then used to model the flow of silicone oils in a cylindrical pipe and estimate the temperature increase due to viscous heating. Numerical results show that the normalized temperature, i.e., ratio of fluid temperature to wall temperature, increases approximately 23%, and the apparent viscosity decreases drastically, going toward the center of the tube. The non-Newtonian nature of fluid is reflected in the presence of a critical region. In this region, the velocity and temperature gradients vanish. Since silicon oil is a surgical tool, we hope that the acquired physicochemical information can provide help to facilitate the removal of this material during surgical procedures.

The fluid-dynamics of bubble-bearing magmas

NASA Astrophysics Data System (ADS)

colucci, simone; papale, paolo; montagna, chiara

2014-05-01

The rheological properties of a fluid establish how the shear stress, τ, is related to the shear strain-rate, γ . The simplest constitutive equation is represented by the linear relationship τ = μγ, where the viscosity parameter, μ, is independent of strain-rate and the velocity profile is parabolic. Fluids with such a flow curve are called Newtonian. Many fluids, though, exhibit non-Newtonian rheology, typically arising in magmas from the presence of a dispersed phase of either crystals or bubbles. In this case it is not possible to define a strain-rate-independent viscosity and the velocity profile is complex. In this work we extend the 1D, steady, isothermal, multiphase non-homogeneous magma ascent model of Papale (2001) to 1.5D including the Non-Newtonian rheology of the bubble-bearing magma. We describe such rheology in terms of an apparent viscosity, η, which is the ratio of stress to strain-rate (η = τ/γ) and varies with strain-rate across the conduit radius. In this way we calculate a depth-dependent Non-newtonian velocity profile across the radius along with shear strain-rate and viscosity distributions. The evolution of the velocity profile can now be studied in order to investigate processes which occur close to the conduit wall, such as fragmentation. Moreover, the model can quantify the effects of the Non-Newtonian rheology on conduit flow dynamics, in terms of flow variables (e.g. velocity, pressure).

Equilibrium Conditions of Sediment Suspending Flows on Earth, Mars and Titan

NASA Astrophysics Data System (ADS)

Amy, L. A.; Dorrell, R. M.

2016-12-01

Sediment entrainment, erosion and deposition by liquid water on Earth is one of the key processes controlling planetary surface evolution. Similar modification of planetary surfaces by liquids associated with a volatile cycle are also inferred to have occurred on other planets (e.g., water on Mars and methane-ethane on Titan). Here we explore conditions for equilibrium flow - the threshold between net sediment erosion and deposition - on different planets. We use a new theoretical model for particle erosion-suspension-deposition: this model shows a better fit to empirical data than comparative suspension criterions (e.g., Rouse Number) since it takes into account both flow competence and capacity, and particle size distribution effects. Shear stresses required to initially entrain sediment and maintain equilibrium flow vary significantly, being several times lower on Mars and more than ten times lower on Titan resulting principally from lower gravities. On all planets it is harder to maintain equilibrium flow as sediment mixtures become poorer sorted (higher shear stresses are needed as standard deviation increases). In comparison to large differences in critical shear stresses, critical slopes for equilibrium flow are similar for planets. Compared to Earth, equilibrium slopes on Mars should be slightly lower whilst those on Titan will be higher or lower for organic and ice particle systems, respectively. Particle size distribution has a similar, order of magnitude effect, on equilibrium slope on each planet. The results highlight that whilst reduced gravity on Titan and Mars significantly decreases the bed shear stress required for particle transport, it also proportionally effects the bed shear stress of moving fluid, such that similar slope gradients are required for equilibrium flow; minor variations in equilibrium slopes are related to differences in the particle-fluid density contrasts as well as fluid viscosities. These results help explain why planetary surfaces share striking similarities in their present or past landscapes and shows that particle size distribution is critical to sediment transport dynamics. Interestingly, particle distribution may vary between planets depending on the particle compositions and weathering regimes, imposing differences in equilibrium conditions.

Physical effects of magnetic fields on the Kelvin-Helmholtz instability in a free shear layer

NASA Astrophysics Data System (ADS)

Liu, Y.; Chen, Z. H.; Zhang, H. H.; Lin, Z. Y.

2018-04-01

The Kelvin-Helmholtz instability of a parallel shear flow with a hyperbolic-tangent velocity profile has been simulated numerically at a high Reynolds number. The fluid is perfectly conducting with low viscosity, and the strength of the applied magnetic field varies from weak to strong. We found that the magnetic field parallel to the mainstream direction has a stabilizing effect on the shear flow. The magnetic field mainly stabilizes short-wave perturbations. Small viscosity and/or slight compressibility could introduce some instability even in the presence of a strong magnetic field in a certain circumstance. The suppressing effect of the magnetic field on the instability is accomplished by two parts: the separating effect of the transverse magnetic pressure and the anti-bending effect of magnetic tension pointing to the center of curvature. The former shows prevailingly stronger effect on the fluid interface than the latter does, which is different from the conventional opinion that magnetic tension dominates. Essentially it is mainly the Maxwell stress that weakens and balances the momentum transport conducted by the Reynolds stress, reducing the mixing degree of the upper fluid and the lower fluid.

Porosity modification during and following deposition of deep-water sediments

NASA Astrophysics Data System (ADS)

Butler, R. W.; McCaffrey, W. D.; Haughton, P.; del Pino Sanchez, A.; Barker, S.; Hailwood, E.; Hakes, B.

2005-12-01

Deposition and early burial of sediments, especially sandy turbidites, are commonly accompanied by the reorganization of porosity structure through the localized expulsion of interstitial fluid. Fluid escape structures are preserved as thin sheets and pipes. Coeval sediment remobilization may be represented by shear structures, commonly taken to indicate down-slope creep and slumping. The history of shearing vs dewatering may be established from cross-cutting structures preserved in outcrop and/or core. Although these relationships are known for gravity-driven soft-sediment deformation on submarine slopes, they can also develop during deposition itself due to shear from the over-riding flow. Such deformation features, including pseudo s-c fabrics and distributed shear, together may previously have been misinterpreted as indicators of palaeoslope (slumps) or even of tectonic deformation. Progressive aggradation of sandy turbidites can show complex banded facies within which soft-sediment deformation is tiered. Syn-deposition micro-growth strata testify to ongoing seabed deformation occurring beneath active flows, while the bedforms themselves provide direct measurements of the magnitude of shear stresses imparted into the seabed and estimates of the shear strength of this substrate. Such banded facies may be interpreted in terms of cyclic partitioning of shear stress into the flow and the substrate. The modified porosity structures and related heterogeneities in permeability of such materials may persist during deeper burial, influencing the rheology of the sediment. These bed-scale processes are reflected in the quality and flow rates of hydrocarbon reservoirs. The reorganization of sand-body architecture through remobilization, by traction and/or down-slope failure, also has a strong impact on the permeability on the multi-bed scale (10s-100s m). Examples will be presented from hydrocarbon reservoirs in the subsurface and from outcrops of Tertiary turbidites in the Alpine-Apennine orogenic system.

Investigation of blood flow rheology using second-grade viscoelastic model (Phan-Thien-Tanner) within carotid artery.

PubMed

Ramiar, Abas; Larimi, Morsal Momenti; Ranjbar, Ali Akbar

2017-01-01

Hemodynamic factors, such as Wall Shear Stress (WSS), play a substantial role in arterial diseases. In the larger arteries, such as the carotid artery, interaction between the vessel wall and blood flow affects the distribution of hemodynamic factors. The fluid is considered to be non-Newtonian, whose flow is governed by the equation of a second-grade viscoelastic fluid and the effects of viscoelastic on blood flow in carotid artery is investigated. Pulsatile flow studies were carried out in a 3D model of carotid artery. The governing equations were solved using finite volume C++ based on open source code, OpenFOAM. To describe blood flow, conservation of mass and momentum, a constitutive relation of simplified Phan-Thien-Tanner (sPTT), and appropriate relations were used to explain shear thinning behavior. The first recirculation was observed at t = 0.2 s, in deceleration phase. In the acceleration phase from t = 0.3 s to t = 0.5 s, vortex and recirculation sizes in bulb regions in both ECA and ICA gradually increased. As is observed in the line graphs based on extracted data from ICA, at t = 0.2 s, τyy is the maximum amount of wall shear stress and τxy the minimum one. The maximum shear stress occurred in the inner side of the main branch (inner side of ICA and ECA) because the velocity of blood flow in the inner side of the bulb region was maximum due to the created recirculation zone in the opposite side in this area. The rheology of blood flow and shear stress in various important parts (the area that are in higher rates of WSS such as bifurcation region and the regions after bulb areas in both branches, Line1-4 in Fig. 7) were also analyzed. The investigation of velocity stream line, velocity profile and shear stress in various sections of carotid artery showed that the maximum shear stress occurred in acceleration phase and in the bifurcation region between ECA and ICA which is due to velocity gradients and changes in thinning behavior of blood and increasing strain rate in Newtonian stress part.

The Progress in the Novel Pediatric Rotary Blood Pump Sputnik Development.

PubMed

Telyshev, Dmitry; Denisov, Maxim; Pugovkin, Alexander; Selishchev, Sergey; Nesterenko, Igor

2018-04-01

In this work, the study results of an implantable pediatric rotary blood pump (PRBP) are presented. They show the results of the numerical simulation of fluid flow rates in the pump. The determination method of the backflows and stagnation regions is represented. The operating points corresponding to fluid flow rates of 1, 3, and 5 L/min for 75-80 mm Hg pressure head are investigated. The study results have shown that use of the pump in the 1 L/min operating point can potentially lead to the appearance of backflows and stagnation regions. In the case of using pumps in fluid flow rates ranging from 3 to 5 L/min, the number of stagnation regions decreases and the fluid flow rate changes marginally. Using the pump in this flow rate range is considered judicious. The study shows an increase in shear stress with an increase in fluid flow rates, while there is no increase in shear stress above the critical condition of 150 Pa (which does not allow us to reliably speak about the increased risk of blood cell damage). The aim of this work was to design, prototype, and study interaction of the Sputnik PRBP with the cardiovascular system. A three-dimensional model of Sputnik PRBP was designed with the following geometrical specifications: flow unit length of 51.5 mm, flow unit diameter of 10 mm, and spacing between the rotor and housing of 0.1 mm. Computational fluid dynamics studies were used to calculate head pressure-flow rate (H-Q) curves at rotor speeds ranging from 10 000 to 14 000 rpm (R 2  = 0.866 between numerical simulation and experiment) and comparing flow patterns at various points of the flow rate operating range (1, 3, and 5 L/min) for operating pressures ranging from 75 to 80 mm Hg. It is noted that when fluid flow rate changes from 1 L/min to 3 L/min, significant changes are observed in the distribution of zero flow zones. At the inlet and outlet of the pump, when going to the operating point of 3 L/min, zones of stagnation become minuscule. The shear stress distribution was calculated along the pump volume. The volume in which shear stress exceed 150 Pa is less than 0.38% of the total pump volume at flow rates of 1, 3, and 5 L/min. In this study, a mock circulatory system (MCS) allowing simulation of physiological cardiovascular characteristics was used to investigate the interaction of the Sputnik PRBP with the cardiovascular system. MCS allows reproducing the Frank-Starling autoregulation mechanism of the heart. PRBP behavior was tested in the speed range of 6 000 to 15 000 rpm. Decreased contractility can be expressed in a stroke volume decrease approximately from 18 to 4 mL and ventricle systolic pressure decrease approximately from 92 to 20 mm Hg. The left ventricle becomes fully supported at a pump speed of 10 000 rpm. At a pump speed of 14 000 rpm, the left ventricle goes into a suction state in which fluid almost does not accumulate in the ventricle and only passes through it to the pump. The proposed PRBP showed potential for improved clinical outcomes in pediatric patients with a body surface area greater than 0.6 m 2 and weight greater than 12 kg. © 2018 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.

Adhesion of leukocytes under oscillating stagnation point conditions: a numerical study.

PubMed

Walker, P G; Alshorman, A A; Westwood, S; David, T

2002-01-01

Leukocyte recruitment from blood to the endothelium plays an important role in atherosclerotic plaque formation. Cells show a primary and secondary adhesive process with primary bonds responsible for capture and rolling and secondary bonds for arrest. Our objective was to investigate the role played by this process on the adhesion of leukocytes in complex flow. Cells were modelled as rigid spheres with spring like adhesion molecules which formed bonds with endothelial receptors. Models of bond kinetics and Newton's laws of motion were solved numerically to determine cell motion. Fluid force was obtained from the local shear rate obtained from a CFD simulation of the flow over a backward facing step.In stagnation point flow the shear rate near the stagnation point has a large gradient such that adherent cells in this region roll to a high shear region preventing permanent adhesion. This is enhanced if a small time dependent perturbation is imposed upon the stagnation point. For lower shear rates the cell rolling velocity may be such that secondary bonds have time to form. These bonds resist the lower fluid forces and consequently there is a relatively large permanent adhesion region.

Modeling the shear rate and pressure drop in a hydrodynamic cavitation reactor with experimental validation based on KI decomposition studies.

PubMed

Badve, Mandar P; Alpar, Tibor; Pandit, Aniruddha B; Gogate, Parag R; Csoka, Levente

2015-01-01

A mathematical model describing the shear rate and pressure variation in a complex flow field created in a hydrodynamic cavitation reactor (stator and rotor assembly) has been depicted in the present study. The design of the reactor is such that the rotor is provided with surface indentations and cavitational events are expected to occur on the surface of the rotor as well as within the indentations. The flow characteristics of the fluid have been investigated on the basis of high accuracy compact difference schemes and Navier-Stokes method. The evolution of streamlining structures during rotation, pressure field and shear rate of a Newtonian fluid flow have been numerically established. The simulation results suggest that the characteristics of shear rate and pressure area are quite different based on the magnitude of the rotation velocity of the rotor. It was observed that area of the high shear zone at the indentation leading edge shrinks with an increase in the rotational speed of the rotor, although the magnitude of the shear rate increases linearly. It is therefore concluded that higher rotational speeds of the rotor, tends to stabilize the flow, which in turn results into less cavitational activity compared to that observed around 2200-2500RPM. Experiments were carried out with initial concentration of KI as 2000ppm. Maximum of 50ppm of iodine liberation was observed at 2200RPM. Experimental as well as simulation results indicate that the maximum cavitational activity can be seen when rotation speed is around 2200-2500RPM. Copyright © 2014 Elsevier B.V. All rights reserved.

EFFECT OF FLUID SHEAR AND IRRADIANCE ON POPULATION GROWTH AND CELLULAR TOXIN CONTENT OF THE DINOFLAGELLATE ALEXANDRIUM FUNDYENSE.

EPA Science Inventory

The potential for in situ turbulence to inhibit dinoflagellate population growth has been demonstrated by experimentally exposing dinoflagellate cultures to quantified shear flow. However, despite interest in understanding environmental factors that affect the growth of toxic din...

Temperature rise and flow of Zr-based bulk metallic glasses under high shearing stress

NASA Astrophysics Data System (ADS)

Zhang, Weiguo; Ma, Mingzhen; Song, Aijun; Liang, Shunxing; Hao, Qiuhong; Tan, Chunlin; Jing, Qin; Liu, Riping

2011-11-01

Deformation of the bulk metallic glasses (BMGs) and the creation and propagation of the shear bands are closely interconnected. Shearing force was loaded on Zr41.2Ti13.8Cu12.5Ni10.0Be22.5(Vit.1) BMGs by cutting during the turning of the BMG rod. The temperature rise of alloy on the shear bands was calculated and the result showed that it could reach the temperature of the super-cooled liquid zone or exceed the melting point. The temperature rise caused viscous fluid flow and brought about the deformation of BMGs. This suggested that the deformation of BMGs was derived, at least to some extent, from the adiabatic shear temperature rise.

Highly elastic polymer solutions under shear: Polymer migration, viscoelastic instabilities, and anomalous rheology

DOE Office of Scientific and Technical Information (OSTI.GOV)

MacDonald, M.J.; Muller, S.J.

1996-12-31

The use of highly elastic polymer solutions has been remarkably successful in elucidating the behavior of polymeric materials under flowing conditions. Here, we present the results of an extensive experimental study into the shear behavior of an athermal, dilute, binary polymer solution that is believed to be free of many of these effects. Under extended shearing, we observe the migration of polymer species: after shearing for several hundred hours, concentrations that are more than double the initial uniform value can be achieved. Although the solutions are well-described by dumbbell models in shear flows on short-time scales, theoretical predictions substantially underestimatemore » the rate of migration. Flow visualization and rheometric experiments suggest that the origin of this discrepancy could be the anomalous long-time rheology of these solutions. While these fluids display the well-known elastic instability in cone and plate flow above a critical Deborah number, extended shearing reveals that the toroidal secondary flow is eventually replaced by a purely azimuthal shearing flow. In addition, when sheared below the critical condition for the instability, the solutions exhibit a slow but reversible decay in normal stresses. The shear-induced migration of polymer species has been predicted by numerous theoretical studies. However, observations on the highly elastic polymer solutions that are most likely to show polymer migration, are complicated by a number of different physical processes that occur as a result of shearing. These phenomena, which include shear-induced phase separation, elastically-induced hydrodynamic instabilities, mixed solvent effects, shear-induced aggregation, and anomalous transient shear and normal stress behavior are often observed at times earlier than and at shear rates less than those where migration is predicted to occur; hence, the experimental detection of polymer migration has been thwarted by these other physical processes.« less

Influence of thickness and permeability of endothelial surface layer on transmission of shear stress in capillaries

NASA Astrophysics Data System (ADS)

Zhang, SongPeng; Zhang, XiangJun; Tian, Yu; Meng, YongGang; Lipowsky, Herbert

2015-07-01

The molecular coating on the surface of microvascular endothelium has been identified as a barrier to transvascular exchange of solutes. With a thickness of hundreds of nanometers, this endothelial surface layer (ESL) has been treated as a porous domain within which fluid shear stresses are dissipated and transmitted to the solid matrix to initiate mechanotransduction events. The present study aims to examine the effects of the ESL thickness and permeability on the transmission of shear stress throughout the ESL. Our results indicate that fluid shear stresses rapidly decrease to insignificant levels within a thin transition layer near the outer boundary of the ESL with a thickness on the order of ten nanometers. The thickness of the transition zone between free fluid and the porous layer was found to be proportional to the square root of the Darcy permeability. As the permeability is reduced ten-fold, the interfacial fluid and solid matrix shear stress gradients increase exponentially two-fold. While the interfacial fluid shear stress is positively related to the ESL thickness, the transmitted matrix stress is reduced by about 50% as the ESL thickness is decreased from 500 to 100 nm, which may occur under pathological conditions. Thus, thickness and permeability of the ESL are two main factors that determine flow features and the apportionment of shear stresses between the fluid and solid phases of the ESL. These results may shed light on the mechanisms of force transmission through the ESL and the pathological events caused by alterations in thickness and permeability of the ESL.

Investigation of Compressibility Effect for Aeropropulsive Shear Flows

NASA Technical Reports Server (NTRS)

Balasubramanyam, M. S.; Chen, C. P.

2005-01-01

Rocket Based Combined Cycle (RBCC) engines operate within a wide range of Mach numbers and altitudes. Fundamental fluid dynamic mechanisms involve complex choking, mass entrainment, stream mixing and wall interactions. The Propulsion Research Center at the University of Alabama in Huntsville is involved in an on- going experimental and numerical modeling study of non-axisymmetric ejector-based combined cycle propulsion systems. This paper attempts to address the modeling issues related to mixing, shear layer/wall interaction in a supersonic Strutjet/ejector flow field. Reynolds Averaged Navier-Stokes (RANS) solutions incorporating turbulence models are sought and compared to experimental measurements to characterize detailed flow dynamics. The effect of compressibility on fluids mixing and wall interactions were investigated using an existing CFD methodology. The compressibility correction to conventional incompressible two- equation models is found to be necessary for the supersonic mixing aspect of the ejector flows based on 2-D simulation results. 3-D strut-base flows involving flow separations were also investigated.

Stress and vascular responses: atheroprotective effect of laminar fluid shear stress in endothelial cells: possible role of mitogen-activated protein kinases.

PubMed

Yoshizumi, Masanori; Abe, Jun-Ichi; Tsuchiya, Koichiro; Berk, Bradford C; Tamaki, Toshiaki

2003-03-01

Atherosclerosis preferentially occurs in areas of turbulent blood flow and low fluid shear stress, whereas laminar blood flow and high shear stress are atheroprotective. Inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha), stimulate expression of endothelial cell (EC) genes that may promote atherosclerosis. Recent findings suggest a steady laminar blood flow decreases EC apoptosis and inhibits TNF-mediated EC activation. EC apoptosis or activation is suggested to be involved in plaque erosion, which may lead to platelet aggregation. TNF-alpha regulates gene expression in ECs, in part, by stimulating mitogen-activated protein (MAP) kinases, which phosphorylate transcription factors. We hypothesized that steady laminar flow inhibits cytokine-mediated activation of MAP kinases in ECs. To test this hypothesis, we determined the effects of steady laminar flow (shear stress = 12 dynes/cm(2)) on TNF-alpha-stimulated activity of three MAP kinases in human umbilical vein ECs (HUVEC): extracellular signal-regulated kinase (ERK1/2), c-Jun N-terminal kinase (JNK), and p38. TNF-alpha activated ERK1/2, JNK, and p38 maximally at 15 min in HUVEC. Pre-exposing HUVEC for 10 min to flow inhibited TNF-alpha activation of JNK, but showed no significant effect on ERK1/2 or p38 activation. Incubation of HUVEC with PD98059, a specific ERK1/2 inhibitor, blocked the flow-mediated inhibition of TNF activation of JNK. Transfection studies with dominant-negative constructs of the protein kinase MEK5 suggested an important role for big mitogen-activated protein kinase 1 (BMK1) in flow-mediated regulation of EC activation by TNF-alpha. Understanding the mechanisms by which steady laminar flow regulates JNK activation by cytokines may provide insight into the atheroprotective mechanisms induced by laminar blood flow.

Upward swimming of a sperm cell in shear flow.

PubMed

Omori, Toshihiro; Ishikawa, Takuji

2016-03-01

Mammalian sperm cells are required to swim over long distances, typically around 1000-fold their own length. They must orient themselves and maintain a swimming motion to reach the ovum, or egg cell. Although the mechanism of long-distance navigation is still unclear, one possible mechanism, rheotaxis, was reported recently. This work investigates the mechanism of the rheotaxis in detail by simulating the motions of a sperm cell in shear flow adjacent to a flat surface. A phase diagram was developed to show the sperm's swimming motion under different shear rates, and for varying flagellum waveform conditions. The results showed that, under shear flow, the sperm is able to hydrodynamically change its swimming direction, allowing it to swim upwards against the flow, which suggests that the upward swimming of sperm cells can be explained using fluid mechanics, and this can then be used to further understand physiology of sperm cell navigation.

Shear dilatancy and acoustic emission in dry and saturated granular materials

NASA Astrophysics Data System (ADS)

Brodsky, E. E.; Siman-Tov, S.

2017-12-01

Shearing of granular materials plays a strong role in naturally sheared systems as landslides and faults. Many works on granular flows have concentrated on dry materials, but relatively little work has been done on water saturated sands. Here we experimentally investigate dry versus saturated quartz-rich sand to understand the effect of the fluid medium on the rheology and acoustic waves emission of the sheared sand. The sand was sheared in a rotary shear rheometer under applied constant normal stress boundary at low (100 µm/s) to high (1 m/s) velocities. Mechanical, acoustic data and deformation were continuously recorded and imaged. For dry and water saturated experiments the granular volume remains constant for low shear velocities ( 10-3 m/s) and increases during shearing at higher velocities ( 1 m/s). Continuous imaging of the sheared sand show that the steady state shear band thickness is thicker during the high velocity steps. No significant change observed in the shear band thickness between dry and water saturated experiments. In contrast, the amount of dilation during water saturated experiments is about half the value measured for dry material. The measured decrease cannot be explained by shear band thickness change as such is not exist. However, the reduced dilation is supported by our acoustic measurements. In general, the event rate and acoustic event amplitudes increase with shear velocity. While isolated events are clearly detected during low velocities at higher the events overlap, resulting in a noisy signal. Although detection is better for saturated experiments, during the high velocity steps the acoustic energy measured from the signal is lower compared to that recorded for dry experiments. We suggest that the presence of fluid suppresses grain motion and particles impacts leading to mild increase in the internal pressure and therefore for the reduced dilation. In addition, the viscosity of fluids may influence the internal pressure via hydrodynamic lubrication which increases the fluid pressure and therefore increases the dilation compared to dry material. The effect is particularly strong for high viscosity fluids, as observed in the silicon oil experiment. Therefore, fluid viscosity can play a crucial role in determining the physics that controls the rheology of the sheared material.

Experimental evidence of a helical, supercritical instability in pipe flow of shear thinning fluids

NASA Astrophysics Data System (ADS)

Picaut, L.; Ronsin, O.; Caroli, C.; Baumberger, T.

2017-08-01

We study experimentally the flow stability of entangled polymer solutions extruded through glass capillaries. We show that the pipe flow becomes linearly unstable beyond a critical value (Wic≃5 ) of the Weissenberg number, via a supercritical bifurcation which results in a helical distortion of the extrudate. We find that the amplitude of the undulation vanishes as the aspect ratio L /R of the capillary tends to zero, and saturates for large L /R , indicating that the instability affects the whole pipe flow, rather than the contraction or exit regions. These results, when compared to previous theoretical and experimental works, lead us to argue that the nature of the instability is controlled by the level of shear thinning of the fluids. In addition, we provide strong hints that the nonlinear development of the instabiilty is mitigated, in our system, by the gradual emergence of gross wall slip.

Interaction of two cylinders in shear flow at low Wi

NASA Astrophysics Data System (ADS)

Brown, M. J.; Leal, L. G.

2001-11-01

Experiments [Lyon et al., 2001; Boussima et al., 1996; Michelle et al., 1977] have shown that non-Brownian, non-Colloidal, and charge-neutral particles, when suspended in viscoelastic media and subjected to shear, will aggregate and flow-align above a critical shear rate Wi O(10). Giesekus [1978] proposed a mechanism for aggregation based on the attractive hoop thrusts about two particles in viscoelastic flow. This pairwise mechanism of attraction is borne out in studies of sedimenting particles [Feng & Joseph, 1996; Joseph et al., 1994], and seems a valid explanation for the aggregation observed in sedimenting suspensions over all Wi > Re [Joseph et al., 1994; Phillips, 1996.] Consideration of the flow around two particles in shear would lead one to expect attraction by this hoop thrust mechanism as well. However, it remains unclear why shear-induced aggregation only occurs above a critical Wi. A first step in understanding this criticality is to establish the low Wi behavior of two particles in shear. In this talk, we report on the interaction of two freely-mobile cylinders as predicted by an n-th order fluid computation.

Computational Analysis of Human Blood Flow

NASA Astrophysics Data System (ADS)

Panta, Yogendra; Marie, Hazel; Harvey, Mark

2009-11-01

Fluid flow modeling with commercially available computational fluid dynamics (CFD) software is widely used to visualize and predict physical phenomena related to various biological systems. In this presentation, a typical human aorta model was analyzed assuming the blood flow as laminar with complaint cardiac muscle wall boundaries. FLUENT, a commercially available finite volume software, coupled with Solidworks, a modeling software, was employed for the preprocessing, simulation and postprocessing of all the models.The analysis mainly consists of a fluid-dynamics analysis including a calculation of the velocity field and pressure distribution in the blood and a mechanical analysis of the deformation of the tissue and artery in terms of wall shear stress. A number of other models e.g. T branches, angle shaped were previously analyzed and compared their results for consistency for similar boundary conditions. The velocities, pressures and wall shear stress distributions achieved in all models were as expected given the similar boundary conditions. The three dimensional time dependent analysis of blood flow accounting the effect of body forces with a complaint boundary was also performed.

Elastic behavior of a red blood cell with the membrane's nonuniform natural state: equilibrium shape, motion transition under shear flow, and elongation during tank-treading motion.

PubMed

Tsubota, Ken-Ichi; Wada, Shigeo; Liu, Hao

2014-08-01

Direct numerical simulations of the mechanics of a single red blood cell (RBC) were performed by considering the nonuniform natural state of the elastic membrane. A RBC was modeled as an incompressible viscous fluid encapsulated by an elastic membrane. The in-plane shear and area dilatation deformations of the membrane were modeled by Skalak constitutive equation, while out-of-plane bending deformation was formulated by the spring model. The natural state of the membrane with respect to in-plane shear deformation was modeled as a sphere ([Formula: see text]), biconcave disk shape ([Formula: see text]) and their intermediate shapes ([Formula: see text]) with the nonuniformity parameter [Formula: see text], while the natural state with respect to out-of-plane bending deformation was modeled as a flat plane. According to the numerical simulations, at an experimentally measured in-plane shear modulus of [Formula: see text] and an out-of-plane bending rigidity of [Formula: see text] of the cell membrane, the following results were obtained. (i) The RBC shape at equilibrium was biconcave discoid for [Formula: see text] and cupped otherwise; (ii) the experimentally measured fluid shear stress at the transition between tumbling and tank-treading motions under shear flow was reproduced for [Formula: see text]; (iii) the elongation deformation of the RBC during tank-treading motion from the simulation was consistent with that from in vitro experiments, irrespective of the [Formula: see text] value. Based on our RBC modeling, the three phenomena (i), (ii), and (iii) were mechanically consistent for [Formula: see text]. The condition [Formula: see text] precludes a biconcave discoid shape at equilibrium (i); however, it gives appropriate fluid shear stress at the motion transition under shear flow (ii), suggesting that a combined effect of [Formula: see text] and the natural state with respect to out-of-plane bending deformation is necessary for understanding details of the RBC mechanics at equilibrium. Our numerical results demonstrate that moderate nonuniformity in a membrane's natural state with respect to in-plane shear deformation plays a key role in RBC mechanics.

Asymptotic stability of shear-flow solutions to incompressible viscous free boundary problems with and without surface tension

NASA Astrophysics Data System (ADS)

Tice, Ian

2018-04-01

This paper concerns the dynamics of a layer of incompressible viscous fluid lying above a rigid plane and with an upper boundary given by a free surface. The fluid is subject to a constant external force with a horizontal component, which arises in modeling the motion of such a fluid down an inclined plane, after a coordinate change. We consider the problem both with and without surface tension for horizontally periodic flows. This problem gives rise to shear-flow equilibrium solutions, and the main thrust of this paper is to study the asymptotic stability of the equilibria in certain parameter regimes. We prove that there exists a parameter regime in which sufficiently small perturbations of the equilibrium at time t=0 give rise to global-in-time solutions that return to equilibrium exponentially in the case with surface tension and almost exponentially in the case without surface tension. We also establish a vanishing surface tension limit, which connects the solutions with and without surface tension.

A Microfluidic Approach for Studying Piezo Channels.

PubMed

Maneshi, M M; Gottlieb, P A; Hua, S Z

2017-01-01

Microfluidics is an interdisciplinary field intersecting many areas in engineering. Utilizing a combination of physics, chemistry, biology, and biotechnology, along with practical applications for designing devices that use low volumes of fluids to achieve high-throughput screening, is a major goal in microfluidics. Microfluidic approaches allow the study of cells growth and differentiation using a variety of conditions including control of fluid flow that generates shear stress. Recently, Piezo1 channels were shown to respond to fluid shear stress and are crucial for vascular development. This channel is ideal for studying fluid shear stress applied to cells using microfluidic devices. We have developed an approach that allows us to analyze the role of Piezo channels on any given cell and serves as a high-throughput screen for drug discovery. We show that this approach can provide detailed information about the inhibitors of Piezo channels. Copyright © 2017 Elsevier Inc. All rights reserved.

Effects of fracture surface roughness and shear displacement on geometrical and hydraulic properties of three-dimensional crossed rock fracture models

NASA Astrophysics Data System (ADS)

Huang, Na; Liu, Richeng; Jiang, Yujing; Li, Bo; Yu, Liyuan

2018-03-01

While shear-flow behavior through fractured media has been so far studied at single fracture scale, a numerical analysis of the shear effect on the hydraulic response of 3D crossed fracture model is presented. The analysis was based on a series of crossed fracture models, in which the effects of fracture surface roughness and shear displacement were considered. The rough fracture surfaces were generated using the modified successive random additions (SRA) algorithm. The shear displacement was applied on one fracture, and at the same time another fracture shifted along with the upper and lower surfaces of the sheared fracture. The simulation results reveal the development and variation of preferential flow paths through the model during the shear, accompanied by the change of the flow rate ratios between two flow planes at the outlet boundary. The average contact area accounts for approximately 5-27% of the fracture planes during shear, but the actual calculated flow area is about 38-55% of the fracture planes, which is much smaller than the noncontact area. The equivalent permeability will either increase or decrease as shear displacement increases from 0 to 4 mm, depending on the aperture distribution of intersection part between two fractures. When the shear displacement continuously increases by up to 20 mm, the equivalent permeability increases sharply first, and then keeps increasing with a lower gradient. The equivalent permeability of rough fractured model is about 26-80% of that calculated from the parallel plate model, and the equivalent permeability in the direction perpendicular to shear direction is approximately 1.31-3.67 times larger than that in the direction parallel to shear direction. These results can provide a fundamental understanding of fluid flow through crossed fracture model under shear.

Oscillatory fluid flow influences primary cilia and microtubule mechanics.

PubMed

Espinha, Lina C; Hoey, David A; Fernandes, Paulo R; Rodrigues, Hélder C; Jacobs, Christopher R

2014-07-01

Many tissues are sensitive to mechanical stimuli; however, the mechanotransduction mechanism used by cells remains unknown in many cases. The primary cilium is a solitary, immotile microtubule-based extension present on nearly every mammalian cell which extends from the basal body. The cilium is a mechanosensitive organelle and has been shown to transduce fluid flow-induced shear stress in tissues, such as the kidney and bone. The majority of microtubules assemble from the mother centriole (basal body), contributing significantly to the anchoring of the primary cilium. Several studies have attempted to quantify the number of microtubules emanating from the basal body and the results vary depending on the cell type. It has also been shown that cellular response to shear stress depends on microtubular integrity. This study hypothesizes that changing the microtubule attachment of primary cilia in response to a mechanical stimulus could change primary cilia mechanics and, possibly, mechanosensitivity. Oscillatory fluid flow was applied to two different cell types and the microtubule attachment to the ciliary base was quantified. For the first time, an increase in microtubules around primary cilia both with time and shear rate in response to oscillatory fluid flow stimulation was demonstrated. Moreover, it is presented that the primary cilium is required for this loading-induced cellular response. This study has demonstrated a new role for the cilium in regulating alterations in the cytoplasmic microtubule network in response to mechanical stimulation, and therefore provides a new insight into how cilia may regulate its mechanics and thus the cells mechanosensitivity. Copyright © 2014 Wiley Periodicals, Inc.

On the micromechanics of slip events in sheared, fluid-saturated fault gouge

NASA Astrophysics Data System (ADS)

Dorostkar, Omid; Guyer, Robert A.; Johnson, Paul A.; Marone, Chris; Carmeliet, Jan

2017-06-01

We used a three-dimensional discrete element method coupled with computational fluid dynamics to study the poromechanical properties of dry and fluid-saturated granular fault gouge. The granular layer was sheared under dry conditions to establish a steady state condition of stick-slip dynamic failure, and then fluid was introduced to study its effect on subsequent failure events. The fluid-saturated case showed increased stick-slip recurrence time and larger slip events compared to the dry case. Particle motion induces fluid flow with local pressure variation, which in turn leads to high particle kinetic energy during slip due to increased drag forces from fluid on particles. The presence of fluid during the stick phase of loading promotes a more stable configuration evidenced by higher particle coordination number. Our coupled fluid-particle simulations provide grain-scale information that improves understanding of slip instabilities and illuminates details of phenomenological, macroscale observations.

High fluid shear strain causes injury in silver shark: Preliminary implications for Mekong hydropower turbine design

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baumgartner, L. J.; Thorncraft, G.; Phonekhampheng, O.

Fluid shear arises when two bodies of water, travelling at different velocities, intersect. Fish entrained at the interface of these two water masses will experience shear stress; which can be harmful. The stress magnitude is dependent on waterbody mass and velocity; with the fish impact largely related to body size. Elevated shear stress occurs where rapidly flowing water passes near spillways, across screens, within turbine draft tubes or other passage routes. A flume was used to determine critical tolerances of silver shark (Balantiocheilos melanopterus) to different shear stress rates generated by a high velocity jet. Fish experienced higher levels ofmore » injury and mortality as shear stress was increased. Excessive shear forces had damaging impacts on fish. Mortality occurred at shear levels higher that 600/s. It is important that developers should attempt to model potential shear profiles expected during turbine passage in selected designs. These data will be critical to determine potential impacts on fish. If the likelihood of adverse impact is high, then alternative designs which have lower shear stress could be explored.« less

The flow of power law fluids in elastic networks and porous media.

PubMed

Sochi, Taha

2016-02-01

The flow of power law fluids, which include shear thinning and shear thickening as well as Newtonian as a special case, in networks of interconnected elastic tubes is investigated using a residual-based pore scale network modeling method with the employment of newly derived formulae. Two relations describing the mechanical interaction between the local pressure and local cross-sectional area in distensible tubes of elastic nature are considered in the derivation of these formulae. The model can be used to describe shear dependent flows of mainly viscous nature. The behavior of the proposed model is vindicated by several tests in a number of special and limiting cases where the results can be verified quantitatively or qualitatively. The model, which is the first of its kind, incorporates more than one major nonlinearity corresponding to the fluid rheology and conduit mechanical properties, that is non-Newtonian effects and tube distensibility. The formulation, implementation, and performance indicate that the model enjoys certain advantages over the existing models such as being exact within the restricting assumptions on which the model is based, easy implementation, low computational costs, reliability, and smooth convergence. The proposed model can, therefore, be used as an alternative to the existing Newtonian distensible models; moreover, it stretches the capabilities of the existing modeling approaches to reach non-Newtonian rheologies.

A comparative numerical analysis of linear and nonlinear aerodynamic sound generation by vortex disturbances in homentropic constant shear flows

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hau, Jan-Niklas, E-mail: hau@fdy.tu-darmstadt.de; Oberlack, Martin; GSC CE, Technische Universität Darmstadt, Dolivostraße 15, 64293 Darmstadt

2015-12-15

Aerodynamic sound generation in shear flows is investigated in the light of the breakthrough in hydrodynamics stability theory in the 1990s, where generic phenomena of non-normal shear flow systems were understood. By applying the thereby emerged short-time/non-modal approach, the sole linear mechanism of wave generation by vortices in shear flows was captured [G. D. Chagelishvili, A. Tevzadze, G. Bodo, and S. S. Moiseev, “Linear mechanism of wave emergence from vortices in smooth shear flows,” Phys. Rev. Lett. 79, 3178-3181 (1997); B. F. Farrell and P. J. Ioannou, “Transient and asymptotic growth of two-dimensional perturbations in viscous compressible shear flow,” Phys.more » Fluids 12, 3021-3028 (2000); N. A. Bakas, “Mechanism underlying transient growth of planar perturbations in unbounded compressible shear flow,” J. Fluid Mech. 639, 479-507 (2009); and G. Favraud and V. Pagneux, “Superadiabatic evolution of acoustic and vorticity perturbations in Couette flow,” Phys. Rev. E 89, 033012 (2014)]. Its source is the non-normality induced linear mode-coupling, which becomes efficient at moderate Mach numbers that is defined for each perturbation harmonic as the ratio of the shear rate to its characteristic frequency. Based on the results by the non-modal approach, we investigate a two-dimensional homentropic constant shear flow and focus on the dynamical characteristics in the wavenumber plane. This allows to separate from each other the participants of the dynamical processes — vortex and wave modes — and to estimate the efficacy of the process of linear wave-generation. This process is analyzed and visualized on the example of a packet of vortex modes, localized in both, spectral and physical, planes. Further, by employing direct numerical simulations, the wave generation by chaotically distributed vortex modes is analyzed and the involved linear and nonlinear processes are identified. The generated acoustic field is anisotropic in the wavenumber plane, which results in highly directional linear sound radiation, whereas the nonlinearly generated waves are almost omni-directional. As part of this analysis, we compare the effectiveness of the linear and nonlinear mechanisms of wave generation within the range of validity of the rapid distortion theory and show the dominance of the linear aerodynamic sound generation. Finally, topological differences between the linear source term of the acoustic analogy equation and of the anisotropic non-normality induced linear mechanism of wave generation are found.« less

Elastic moduli of a Brownian colloidal glass former

NASA Astrophysics Data System (ADS)

Fritschi, S.; Fuchs, M.

2018-01-01

The static, dynamic and flow-dependent shear moduli of a binary mixture of Brownian hard disks are studied by an event-driven molecular dynamics simulation. Thereby, the emergence of rigidity close to the glass transition encoded in the static shear modulus G_∞ is accessed by three methods. Results from shear stress auto-correlation functions, elastic dispersion relations, and the elastic response to strain deformations upon the start-up of shear flow are compared. This enables one to sample the time-dependent shear modulus G(t) consistently over several decades in time. By that a very precise specification of the glass transition point and of G_∞ is feasible. Predictions by mode coupling theory of a finite shear modulus at the glass transition, of α-scaling in fluid states close to the transition, and of shear induced decay in yielding glass states are tested and broadly verified.

Using Ultrasonic Speckle Velocimetry to Detect Fluid Instabilities in a Surfactant Solution

NASA Astrophysics Data System (ADS)

Bice, Jason E.

Rheometry is a leading technology used to define material properties of multi-phase viscoelastic fluid-like materials, such as the shear modulus and viscosity. However, traditional rheometry relies on a mechanical response from a rotating or oscillating rotor of various geometries which does not allow for any spatial or temporal quantification of the material characteristics. Further, the setup operates under the assumption of a uniform and homogeneous flow. Thus, only qualitative deductions can be realized when a complex fluid displays inhomogeneous behavior, such as wall slip or shear banding. Due to this lack of capability, non-intrusive imaging is required to define and quantify behavior that occurs in a complex fluid under shear conditions. This thesis outlines the design, fabrication, and experimental examples of an adapted ultrasonic speckle velocimetry device, which enables spatial and temporal resolution of inhomogeneous fluid behavior using ultrasound acoustics. For the experimental example, a commercial surfactant mixture (hair shampoo) was tested to show the utility and precision that ultrasonic speckle velocimetry possesses.

Remedial Amendment Delivery near the Water Table Using Shear Thinning Fluids: Experiments and Numerical Simulations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Oostrom, Martinus; Truex, Michael J.; Vermeul, Vincent R.

2014-08-19

The use of shear thinning fluids (STFs) containing xanthan is a potential enhancement for emplacing a solute amendment near the water table and within the capillary fringe. Most research to date related to STF behavior has involved saturated and confined conditions. A series of flow cell experiments were conducted to investigate STF emplacement in variable saturated homogeneous and layered heterogeneous systems. Besides flow visualization using dyes, amendment concentrations and pressure data were obtained at several locations. The experiments showed that injection of STFs considerably improved the subsurface distribution near the water table by mitigating preferential flow through higher permeability zonesmore » compared to no-polymer injections. The phosphate amendment migrated with the xanthan SFT without retardation. Despite the high viscosity of the STF, no excessive mounding or preferential flow were observed in the unsaturated zone. The STOMP simulator was able to predict the experimentally observed fluid displacement and amendment concentrations reasonably well. Cross flow between layers could be interpreted as the main mechanism to transport STFs into lower permeability layers based on the observed pressure gradient and concentration data in layers of differing hydraulic conductivity.« less

Creep cavitation bands control porosity and fluid flow in lower crustal shear zones

DOE Office of Scientific and Technical Information (OSTI.GOV)

Menegon, Luca; Fusseis, Florian; Stunitz, Holger

2015-03-01

Shear zones channelize fluid flow in Earth’s crust. However, little is known about deep crustal fluid migration and how fluids are channelized and distributed in a deforming lower crustal shear zone. This study investigates the deformation mechanisms, fluid-rock interaction, and development of porosity in a monzonite ultramylonite from Lofoten, northern Norway. The rock was deformed and transformed into an ultramylonite under lower crustal conditions (temperature = 700–730 °C, pressure = 0.65–0.8 GPa). The ultramylonite consists of feldspathic layers and domains of amphibole + quartz + calcite, which result from hydration reactions of magmatic clinopyroxene. The average grain size in bothmore » domains is <25 mm. Microstructural observations and electron backscatter diffraction analysis are consistent with diffusion creep as the dominant deformation mechanism in both domains. Festoons of isolated quartz grains define C'-type bands in feldspathic layers. These quartz grains do not show a crystallographic preferred orientation. The alignment of quartz grains is parallel to the preferred elongation of pores in the ultramylonites, as evidenced from synchrotron X-ray microtomography. Such C'-type bands are interpreted as creep cavitation bands resulting from diffusion creep deformation associated with grain boundary sliding. Mass-balance calculation indicates a 2% volume increase during the protolith-ultramylonite transformation, which is consistent with synkinematic formation of creep cavities producing dilatancy. Thus, this study presents evidence that creep cavitation bands may control deep crustal porosity and fluid flow. Nucleation of new phases in creep cavitation bands inhibits grain growth and enhances the activity of grain size–sensitive creep, thereby stabilizing strain localization in the polymineralic ultramylonites.« less

Synchronization and Random Triggering of Lymphatic Vessel Contractions

PubMed Central

Baish, James W.; Kunert, Christian; Padera, Timothy P.; Munn, Lance L.

2016-01-01

The lymphatic system is responsible for transporting interstitial fluid back to the bloodstream, but unlike the cardiovascular system, lacks a centralized pump-the heart–to drive flow. Instead, each collecting lymphatic vessel can individually contract and dilate producing unidirectional flow enforced by intraluminal check valves. Due to the large number and spatial distribution of such pumps, high-level coordination would be unwieldy. This leads to the question of how each segment of lymphatic vessel responds to local signals that can contribute to the coordination of pumping on a network basis. Beginning with elementary fluid mechanics and known cellular behaviors, we show that two complementary oscillators emerge from i) mechanical stretch with calcium ion transport and ii) fluid shear stress induced nitric oxide production (NO). Using numerical simulation and linear stability analysis we show that the newly identified shear-NO oscillator shares similarities with the well-known Van der Pol oscillator, but has unique characteristics. Depending on the operating conditions, the shear-NO process may i) be inherently stable, ii) oscillate spontaneously in response to random disturbances or iii) synchronize with weak periodic stimuli. When the complementary shear-driven and stretch-driven oscillators interact, either may dominate, producing a rich family of behaviors similar to those observed in vivo. PMID:27935958

Synchronization and Random Triggering of Lymphatic Vessel Contractions.

PubMed

Baish, James W; Kunert, Christian; Padera, Timothy P; Munn, Lance L

2016-12-01

The lymphatic system is responsible for transporting interstitial fluid back to the bloodstream, but unlike the cardiovascular system, lacks a centralized pump-the heart-to drive flow. Instead, each collecting lymphatic vessel can individually contract and dilate producing unidirectional flow enforced by intraluminal check valves. Due to the large number and spatial distribution of such pumps, high-level coordination would be unwieldy. This leads to the question of how each segment of lymphatic vessel responds to local signals that can contribute to the coordination of pumping on a network basis. Beginning with elementary fluid mechanics and known cellular behaviors, we show that two complementary oscillators emerge from i) mechanical stretch with calcium ion transport and ii) fluid shear stress induced nitric oxide production (NO). Using numerical simulation and linear stability analysis we show that the newly identified shear-NO oscillator shares similarities with the well-known Van der Pol oscillator, but has unique characteristics. Depending on the operating conditions, the shear-NO process may i) be inherently stable, ii) oscillate spontaneously in response to random disturbances or iii) synchronize with weak periodic stimuli. When the complementary shear-driven and stretch-driven oscillators interact, either may dominate, producing a rich family of behaviors similar to those observed in vivo.

Phakic iris-fixated intraocular lens placement in the anterior chamber: effects on aqueous flow.

PubMed

Repetto, Rodolfo; Pralits, Jan O; Siggers, Jennifer H; Soleri, Paolo

2015-05-01

Phakic intraocular lenses (pIOLs) are used for correcting vision; in this paper we investigate the fluid dynamical effects of an iris-fixated lens in the anterior chamber. In particular, we focus on changes in the wall shear stress (WSS) on the cornea and iris, which could be responsible for endothelial and pigment cell loss, respectively, and also on the possible increase of the intraocular pressure, which is known to correlate with the incidence of secondary glaucoma. We use a mathematical model to study fluid flow in the anterior chamber in the presence of a pIOL. The governing equations are solved numerically using the open source software OpenFOAM. We use an idealized standard geometry for the anterior chamber and a realistic geometric description of the pIOL. We consider separately the main mechanisms that produce fluid flow in the anterior chamber. The numerical simulations allow us to obtain a detailed description of the velocity and pressure distribution in the anterior chamber, and indicated that implantation of the pIOL significantly modifies the fluid dynamics in the anterior chamber. However, lens implantation has negligible influence on the intraocular pressure and does not produce a significant increase of the shear stress on the cornea, while the shear stress on the iris, although increased, is not enough to cause detachment of cells. We conclude that alterations in the fluid dynamics in the anterior chamber as a result of lens implantation are unlikely to be the cause of medical complications associated with its use.

A model for complex flows of soft glassy materials with application to flows through fixed fiber beds

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sarkar, Arijit; Koch, Donald L., E-mail: dlk15@cornell.edu

2015-11-15

The soft glassy rheology (SGR) model has successfully described the time dependent simple shear rheology of a broad class of complex fluids including foams, concentrated emulsions, colloidal glasses, and solvent-free nanoparticle-organic hybrid materials (NOHMs). The model considers a distribution of mesoscopic fluid elements that hop from trap to trap at a rate which is enhanced by the work done to strain the fluid element. While an SGR fluid has a broad exponential distribution of trap energies, the rheology of NOHMs is better described by a narrower energy distribution and we consider both types of trap energy distributions in this study.more » We introduce a tensorial version of these models with a hopping rate that depends on the orientation of the element relative to the mean stress field, allowing a range of relative strengths of the extensional and simple shear responses of the fluid. As an application of these models we consider the flow of a soft glassy material through a dilute fixed bed of fibers. The dilute fixed bed exhibits a range of local linear flows which alternate in a chaotic manner with time in a Lagrangian reference frame. It is amenable to an analytical treatment and has been used to characterize the strong flow response of many complex fluids including fiber suspensions, dilute polymer solutions and emulsions. We show that the accumulated strain in the fluid elements has an abrupt nonlinear growth at a Deborah number of order one in a manner similar to that observed for polymer solutions. The exponential dependence of the hopping rate on strain leads to a fluid element deformation that grows logarithmically with Deborah number at high Deborah numbers. SGR fluids having a broad range of trap energies flowing through fixed beds can exhibit a range of rheological behaviors at small Deborah numbers ranging from a yield stress, to a power law response and finally to Newtonian behavior.« less

Inflectional instabilities in the wall region of bounded turbulent shear flows

NASA Technical Reports Server (NTRS)

Swearingen, Jerry D.; Blackwelder, Ron F.; Spalart, Philippe R.

1987-01-01

The primary thrust of this research was to identify one or more mechanisms responsible for strong turbulence production events in the wall region of bounded turbulent shear flows. Based upon previous work in a transitional boundary layer, it seemed highly probable that the production events were preceded by an inflectional velocity profile which formed on the interface between the low-speed streak and the surrounding fluid. In bounded transitional flows, this unstable profile developed velocity fluctuations in the streamwise direction and in the direction perpendicular to the sheared surface. The rapid growth of these instabilities leads to a breakdown and production of turbulence. Since bounded turbulent flows have many of the same characteristics, they may also experience a similar type of breakdown and turbulence production mechanism.

Magnetic field generation from shear flow in flux ropes

NASA Astrophysics Data System (ADS)

Intrator, T. P.; Sears, J.; Gao, K.; Klarenbeek, J.; Yoo, C.

2012-10-01

In the Reconnection Scaling Experiment (RSX) we have measured out of plane quadrupole magnetic field structure in situations where magnetic reconnection was minimal. This quadrupole out of plane magnetic signature has historically been presumed to be the smoking gun harbinger of reconnection. On the other hand, we showed that when flux ropes bounced instead of merging and reconnecting, this signature could evolve. This can follow from sheared fluid flows in the context of a generalized Ohms Law. We reconstruct a shear flow model from experimental data for flux ropes that have been experimentally well characterized in RSX as screw pinch equilibria, including plasma ion and electron flow, with self consistent profiles for magnetic field, pressure, and current density. The data can account for the quadrupole field structure.

Relativistic thermal electron scale instabilities in sheared flow plasma

NASA Astrophysics Data System (ADS)

Miller, Evan D.; Rogers, Barrett N.

2016-04-01

> The linear dispersion relation obeyed by finite-temperature, non-magnetized, relativistic two-fluid plasmas is presented, in the special case of a discontinuous bulk velocity profile and parallel wave vectors. It is found that such flows become universally unstable at the collisionless electron skin-depth scale. Further analyses are performed in the limits of either free-streaming ions or ultra-hot plasmas. In these limits, the system is highly unstable in the parameter regimes associated with either the electron scale Kelvin-Helmholtz instability (ESKHI) or the relativistic electron scale sheared flow instability (RESI) recently highlighted by Gruzinov. Coupling between these modes provides further instability throughout the remaining parameter space, provided both shear flow and temperature are finite. An explicit parameter space bound on the highly unstable region is found.

Observations of shear flows in high-energy-density plasmas

NASA Astrophysics Data System (ADS)

Harding, Eric C.

The research discussed in this thesis represents work toward the demonstration of experimental designs for creating a Kelvin-Helmholtz (KH) unstable shear layer in a high-energy-density (HED) plasma. Such plasmas are formed by irradiating materials with several kilo-Joules of laser light over a few nanoseconds, and are defined as having an internal pressure greater than one-million atmospheres. Similar plasmas exist in laboratory fusion experiments and in the astrophysical environment. The KH instability is a fundamental fluid instability that arises when strong velocity gradients exist at the interface between two fluids. The KH instability is important because it drives the mixing of fluids and initiates the transition to turbulence in the flow. Until now, the evolution of the KH instability has remained relatively unexplored in the HED regime This thesis presents the observations and analysis of two novel experiments carried out using two separate laser facilities. The first experiment used 1.4 kJ from the Nike laser to generate a supersonic flow of Al plasma over a low-density, rippled foam surface. The Al flow interacted with the foam and created distinct features that resulted from compressible effects. In this experiment there is little evidence of the KH instability. Nevertheless, this experimental design has perhaps pioneered a new method for generating a supersonic shear flow that has the potential to produce the KH instability if more laser energy is applied. The second experiment was performed on the Omega laser. In this case 4.3 kJ of laser energy drove a blast wave along a rippled foam/plastic interface. In response to the vorticity deposited and the shear flow established by the blast wave, the interface rolls up into large vorticies characteristic of the KH instability. The Omega experiment was the first HED experiment to capture the evolution of the KH instability.

Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia

PubMed Central

Baeyens, Nicolas; Larrivée, Bruno; Ola, Roxana; Hayward-Piatkowskyi, Brielle; Dubrac, Alexandre; Huang, Billy; Ross, Tyler D.; Coon, Brian G.; Min, Elizabeth; Tsarfati, Maya; Tong, Haibin; Eichmann, Anne

2016-01-01

Morphogenesis of the vascular system is strongly modulated by mechanical forces from blood flow. Hereditary hemorrhagic telangiectasia (HHT) is an inherited autosomal-dominant disease in which arteriovenous malformations and telangiectasias accumulate with age. Most cases are linked to heterozygous mutations in Alk1 or Endoglin, receptors for bone morphogenetic proteins (BMPs) 9 and 10. Evidence suggests that a second hit results in clonal expansion of endothelial cells to form lesions with poor mural cell coverage that spontaneously rupture and bleed. We now report that fluid shear stress potentiates BMPs to activate Alk1 signaling, which correlates with enhanced association of Alk1 and endoglin. Alk1 is required for BMP9 and flow responses, whereas endoglin is only required for enhancement by flow. This pathway mediates both inhibition of endothelial proliferation and recruitment of mural cells; thus, its loss blocks flow-induced vascular stabilization. Identification of Alk1 signaling as a convergence point for flow and soluble ligands provides a molecular mechanism for development of HHT lesions. PMID:27646277

A microfabricated microfluidic bioMEMS device to model human brain aneurisms: the aneurysm-on-a-chip

NASA Astrophysics Data System (ADS)

Reece, Lisa M.; Khor, Jian Wei; Thakur, Raviraj; Amin, Ahmed; Wereley, Steven T.; Leary, James F.

2015-03-01

Aneurysms are pockets of blood that collect outside blood vessel walls forming dilatations and leaving arterial walls very prone to rupture. There is little information concerning the causes of intracranial aneurysm formation, growth, and rupture. Current treatments include: (1) clipping, and (2) coil embolization, including stent-assisted coiling. Further, the evolution of any aneurysm is assumed to be caused by the remodeling of the affected blood vessel's material constituents (tunica intima, tunica media, or tunica adventitia). Velocity, pressure, and wall shear stresses aid in the disease development of aneurysmal growth, while the shear force mechanisms effecting wound closure are elusive. To study aneurysm pathogenesis, a lab-on-a-chip device is the key to discovering the underlying mechanisms of these lesions. A two-dimensional microfluidic model, the Aneurysm-on-a-Chip™ (AOC), was the logical answer to study particle flow within an aneurysm "sac". The AOC apparatus can track particles/cells when it is coupled to particle image velocimetry software (PIV) package. The AOC fluid flow was visualized using standard microscopy techniques with commercial microparticles and human aortic smooth muscle cells (HASMC). Images were taken during fluid flow experiments and PIV was utilized to monitor the flow of particles within the "sac" region, as well as particles entering and exiting the device. Quiver plots were generated from fluid flow experiments using standard 7 μm latex particles and fixed HASMC in PBS. PIV analysis shows that the particles flowed nicely from input to output. Wall shear stress provided evidence that there was some back flow at the edges of the "sac" - an indicator of aneurysm development in human patients.

A constitutive law for dense granular flows.

PubMed

Jop, Pierre; Forterre, Yoël; Pouliquen, Olivier

2006-06-08

A continuum description of granular flows would be of considerable help in predicting natural geophysical hazards or in designing industrial processes. However, the constitutive equations for dry granular flows, which govern how the material moves under shear, are still a matter of debate. One difficulty is that grains can behave like a solid (in a sand pile), a liquid (when poured from a silo) or a gas (when strongly agitated). For the two extreme regimes, constitutive equations have been proposed based on kinetic theory for collisional rapid flows, and soil mechanics for slow plastic flows. However, the intermediate dense regime, where the granular material flows like a liquid, still lacks a unified view and has motivated many studies over the past decade. The main characteristics of granular liquids are: a yield criterion (a critical shear stress below which flow is not possible) and a complex dependence on shear rate when flowing. In this sense, granular matter shares similarities with classical visco-plastic fluids such as Bingham fluids. Here we propose a new constitutive relation for dense granular flows, inspired by this analogy and recent numerical and experimental work. We then test our three-dimensional (3D) model through experiments on granular flows on a pile between rough sidewalls, in which a complex 3D flow pattern develops. We show that, without any fitting parameter, the model gives quantitative predictions for the flow shape and velocity profiles. Our results support the idea that a simple visco-plastic approach can quantitatively capture granular flow properties, and could serve as a basic tool for modelling more complex flows in geophysical or industrial applications.

Dynamic transverse shear modulus for a heterogeneous fluid-filled porous solid containing cylindrical inclusions

NASA Astrophysics Data System (ADS)

Song, Yongjia; Hu, Hengshan; Rudnicki, John W.; Duan, Yunda

2016-09-01

An exact analytical solution is presented for the effective dynamic transverse shear modulus in a heterogeneous fluid-filled porous solid containing cylindrical inclusions. The complex and frequency-dependent properties of the dynamic shear modulus are caused by the physical mechanism of mesoscopic-scale wave-induced fluid flow whose scale is smaller than wavelength but larger than the size of pores. Our model consists of three phases: a long cylindrical inclusion, a cylindrical shell of poroelastic matrix material with different mechanical and/or hydraulic properties than the inclusion and an outer region of effective homogeneous medium of laterally infinite extent. The behavior of both the inclusion and the matrix is described by Biot's consolidation equations, whereas the surrounding effective medium which is used to describe the effective transverse shear properties of the inner poroelastic composite is assumed to be a viscoelastic solid whose complex transverse shear modulus needs to be determined. The determined effective transverse shear modulus is used to quantify the S-wave attenuation and velocity dispersion in heterogeneous fluid-filled poroelastic rocks. The calculation shows the relaxation frequency and relative position of various fluid saturation dispersion curves predicted by this study exhibit very good agreement with those of a previous 2-D finite-element simulation. For the double-porosity model (inclusions having a different solid frame than the matrix but the same pore fluid as the matrix) the effective shear modulus also exhibits a size-dependent characteristic that the relaxation frequency moves to lower frequencies by two orders of magnitude if the radius of the cylindrical poroelastic composite increases by one order of magnitude. For the patchy-saturation model (inclusions having the same solid frame as the matrix but with a different pore fluid from the matrix), the heterogeneity in pore fluid cannot cause any attenuation in the transverse shear modulus at all. A comparison with the case of spherical inclusions illustrates that the transverse shear modulus for the cylindrical inclusion exhibits more S-wave attenuation than spherical inclusions.

Electromotive force and large-scale magnetic dynamo in a turbulent flow with a mean shear.

PubMed

Rogachevskii, Igor; Kleeorin, Nathan

2003-09-01

An effect of sheared large-scale motions on a mean electromotive force in a nonrotating turbulent flow of a conducting fluid is studied. It is demonstrated that in a homogeneous divergence-free turbulent flow the alpha effect does not exist, however a mean magnetic field can be generated even in a nonrotating turbulence with an imposed mean velocity shear due to a "shear-current" effect. A mean velocity shear results in an anisotropy of turbulent magnetic diffusion. A contribution to the electromotive force related to the symmetric parts of the gradient tensor of the mean magnetic field (the kappa effect) is found in nonrotating turbulent flows with a mean shear. The kappa effect and turbulent magnetic diffusion reduce the growth rate of the mean magnetic field. It is shown that a mean magnetic field can be generated when the exponent of the energy spectrum of the background turbulence (without the mean velocity shear) is less than 2. The shear-current effect was studied using two different methods: the tau approximation (the Orszag third-order closure procedure) and the stochastic calculus (the path integral representation of the solution of the induction equation, Feynman-Kac formula, and Cameron-Martin-Girsanov theorem). Astrophysical applications of the obtained results are discussed.

Atomic Force Microscope Mediated Chromatography

NASA Technical Reports Server (NTRS)

Anderson, Mark S.

2013-01-01

The atomic force microscope (AFM) is used to inject a sample, provide shear-driven liquid flow over a functionalized substrate, and detect separated components. This is demonstrated using lipophilic dyes and normal phase chromatography. A significant reduction in both size and separation time scales is achieved with a 25-micron-length column scale, and one-second separation times. The approach has general applications to trace chemical and microfluidic analysis. The AFM is now a common tool for ultra-microscopy and nanotechnology. It has also been demonstrated to provide a number of microfluidic functions necessary for miniaturized chromatography. These include injection of sub-femtoliter samples, fluidic switching, and sheardriven pumping. The AFM probe tip can be used to selectively remove surface layers for subsequent microchemical analysis using infrared and tip-enhanced Raman spectroscopy. With its ability to image individual atoms, the AFM is a remarkably sensitive detector that can be used to detect separated components. These diverse functional components of microfluidic manipulation have been combined in this work to demonstrate AFM mediated chromatography. AFM mediated chromatography uses channel-less, shear-driven pumping. This is demonstrated with a thin, aluminum oxide substrate and a non-polar solvent system to separate a mixture of lipophilic dyes. In conventional chromatographic terms, this is analogous to thin-layer chromatography using normal phase alumina substrate with sheardriven pumping provided by the AFM tip-cantilever mechanism. The AFM detection of separated components is accomplished by exploiting the variation in the localized friction of the separated components. The AFM tip-cantilever provides the mechanism for producing shear-induced flows and rapid pumping. Shear-driven chromatography (SDC) is a relatively new concept that overcomes the speed and miniaturization limitations of conventional liquid chromatography. SDC is based on a sliding plate system, consisting of two flat surfaces, one of which has a recessed channel. A fluid flow is produced by axially sliding one plate past another, where the fluid has mechanical shear forces imposed at each point along the channel length. The shear-induced flow rates are very reproducible, and do not have pressure or voltage gradient limitations. SDC opens up a new range of enhanced separation kinetics by permitting the sample confinement with submicron dimensions. Small, highly confined liquid is advantageous for chromatographic separation because the separation rate is known to scale according to the square of the confined sample diameter. In addition, because shear-driven flows are not limited by fluid velocity, shear-driven liquid chromatography may provide up to 100,000 plate efficiency.

Resonant fast dynamo

NASA Technical Reports Server (NTRS)

Strauss, H. R.

1986-01-01

A resonant fast dynamo is found in chaotic shear flows. The dynamo effect is produced by resonant perturbations of the velocity field, similar to resonant diffusion in plasma physics. The dynamo is called fast because the flow produces an electric field independent of the fluid resistivity.

An in vitro experimental study of flow past aortic valve under varied pulsatile conditions

NASA Astrophysics Data System (ADS)

Zhang, Ruihang; Zhang, Yan

2017-11-01

Flow past aortic valve represents a complex fluid-structure interaction phenomenon that involves pulsatile, vortical, and turbulent conditions. The flow characteristics immediately downstream of the valve, such as the variation of pulsatile flow velocity, formation of vortices, distribution of shear stresses, are of particular interest to further elucidate the role of hemodynamics in various aortic diseases. However, the fluid dynamics of a realistic aortic valve is not fully understood. Particularly, it is unclear how the flow fields downstream of the aortic valve would change under varied pulsatile inlet boundary conditions. In this study, an in vitro experiment has been conducted to investigate the flow fields downstream of a silicone aortic valve model within a cardiovascular flow simulator. Phased-locked Particle Image Velocimetry measurements were performed to map the velocity fields and Reynolds normal and shear stresses at different phases in a cardiac cycle. Temporal variations of pressure across the valve model were measured using high frequency transducers. Results have been compared for different pulsatile inlet conditions, including varied frequencies (heart rates), magnitudes (stroke volumes), and cardiac contractile functions (shapes of waveforms).

Global chaotization of fluid particle trajectories in a sheared two-layer two-vortex flow.

PubMed

Ryzhov, Evgeny A; Koshel, Konstantin V

2015-10-01

In a two-layer quasi-geostrophic approximation, we study the irregular dynamics of fluid particles arising due to two interacting point vortices embedded in a deformation flow consisting of shear and rotational components. The two vortices are arranged within the bottom layer, but an emphasis is on the upper-layer fluid particle motion. Vortices moving in one layer induce stirring of passive scalars in the other layer. This is of interest since point vortices induce singular velocity fields in the layer they belong to; however, in the other layer, they induce regular velocity fields that generally result in a change in passive particle stirring. If the vortices are located at stagnation points, there are three different types of the fluid flow. We examine how properties of each flow configuration are modified if the vortices are displaced from the stagnation points and thus circulate in the immediate vicinity of these points. To that end, an analysis of the steady-state configurations is presented with an emphasis on the frequencies of fluid particle oscillations about the elliptic stagnation points. Asymptotic relations for the vortex and fluid particle zero-oscillation frequencies are derived in the vicinity of the corresponding elliptic points. By comparing the frequencies of fluid particles with the ones of the vortices, relations between the parameters that lead to enhanced stirring of fluid particles are established. It is also demonstrated that, if the central critical point is elliptic, then the fluid particle trajectories in its immediate vicinity are mostly stable making it harder for the vortex perturbation to induce stirring. Change in the type of the central point to a hyperbolic one enhances drastically the size of the chaotic dynamics region. Conditions on the type of the central critical point also ensue from the derived asymptotic relations.

Viscosity and non-Newtonian features of thickened fluids used for dysphagia therapy.

PubMed

O'Leary, Mark; Hanson, Ben; Smith, Christina

2010-08-01

Thickening agents based primarily on granulated maize starch are widely used in the care of patients with swallowing difficulties, increasing viscosity of consumed fluids. This slows bolus flow during swallowing, allowing airway protection to be more properly engaged. Thickened fluids have been shown to exhibit time-varying behavior and are non-Newtonian, complicating assessment of fluid thickness, potentially compromising efficacy of therapy. This work aimed to quantify the flow properties of fluids produced with commercial thickeners at shear rates representative of slow tipping in a beaker to fast swallowing. Results were presented as indices calculated using a power-law model representing apparent viscosity (consistency index) and non-Newtonian nature of flow (flow behavior index). Immediately following mixing, 3 fluid thicknesses showed distinct consistency indices and decreasing flow behavior index with increasing thickener concentration. An increase in consistency index over 30 min was observed, but only for samples that were repeatedly sheared during acquisition. Three-hour measurements showed changes in consistency index across fluids with the largest being a 25% rise from initial value. This may have implications for efficacy of treatment, as fluids are not always consumed immediately upon mixing. Flow behavior indices were comparable across thickeners exhibiting similar rises over time. The indices were a more complete method of quantifying flow properties compared with single viscosity measurements, allowing an increased depth of analysis. The non-Newtonian nature of fluids perhaps renders them particularly suitable for use as dysphagia therapies, and such analysis may allow the possibility of altering these properties to optimize therapeutic efficacy to be explored. Practical Application: Effective treatment of swallowing disorders relies upon the appropriate choice and subsequent reproduction of drinks thickened to one of a number of predetermined levels. Currently there are no agreed methods of measuring the thickness of these drinks in use and the specifications are subjective, relying on descriptions such as "syrup" thick. This research aims to further understanding of the flow properties of thickened drinks and bring a quantified measure of thickness closer to being a practical reality.

The change in orientation of subsidiary shears near faults containing pore fluid under high pressure

USGS Publications Warehouse

Byerlee, J.

1992-01-01

Byerlee, J., 1992. The change in orientation of subsidiary shears near faults containing pore fluid under high pressure. In: T. Mikumo, K. Aki, M. Ohnaka, L.J. Ruff and P.K.P. Spudich (Editors), Earthquake Source Physics and Earthquake Precursors. Tectonophysics, 211: 295-303. The mechanical effects of a fault containing near-lithostatic fluid pressure in which fluid pressure decreases monotonically from the core of the fault zone to the adjacent country rock is considered. This fluid pressure distribution has mechanical implications for the orientation of subsidiary shears around a fault. Analysis shows that the maximum principal stress is oriented at a high angle to the fault in the country rock where the pore pressure is hydrostatic, and rotates to 45?? to the fault within the fault zone where the pore pressure is much higher. This analysis suggests that on the San Andreas fault, where heat flow constraints require that the coefficient of friction for slip on the fault be less than 0.1, the pore fluid pressure on the main fault is 85% of the lithostatic pressure. The observed geometry of the subsidiary shears in the creeping section of the San Andreas are broadly consistent with this model, with differences that may be due to the heterogeneous nature of the fault. ?? 1992.

Bubble Motion through a Generalized Power-Law Fluid Flowing in a Vertical Tube

PubMed Central

Mukundakrishnan, Karthik; Eckmann, David M.; Ayyaswamy, P. S.

2009-01-01

Intravascular gas embolism may occur with decompression in space flight, as well as during cardiac and vascular surgery. Intravascular bubbles may be deposited into any end organ, such as the heart or the brain. Surface interactions between the bubble and the endothelial cells lining the vasculature result in serious impairment of blood flow and can lead to heart attack, stroke, or even death. To develop effective therapeutic strategies, there is a need for understanding the dynamics of bubble motion through blood and its interaction with the vessel wall through which it moves. Toward this goal, we numerically investigate the axisymmetric motion of a bubble moving through a vertical circular tube in a shear-thinning generalized power-law fluid, using a front-tracking method. The formulation is characterized by the inlet Reynolds number, capillary number, Weber number, and Froude number. The flow dynamics and the associated wall shear stresses are documented for a combination of two different inlet flow conditions (inlet Reynolds numbers) and three different effective bubble radii (ratio of the undeformed bubble radii to the tube radii). The results of the non-Newtonian model are then compared with that of the model assuming a Newtonian blood viscosity. Specifically, for an almost occluding bubble (effective bubble radius = 0.9), the wall shear stress and the bubble residence time are compared for both Newtonian and non-Newtonian cases. Results show that at low shear rates, for a given pressure gradient the residence time for a non-Newtonian flow is higher than that for a Newtonian flow. PMID:19426324

Bone tissue engineering: the role of interstitial fluid flow

NASA Technical Reports Server (NTRS)

Hillsley, M. V.; Frangos, J. A.

1994-01-01

It is well established that vascularization is required for effective bone healing. This implies that blood flow and interstitial fluid (ISF) flow are required for healing and maintenance of bone. The fact that changes in bone blood flow and ISF flow are associated with changes in bone remodeling and formation support this theory. ISF flow in bone results from transcortical pressure gradients produced by vascular and hydrostatic pressure, and mechanical loading. Conditions observed to alter flow rates include increases in venous pressure in hypertension, fluid shifts occurring in bedrest and microgravity, increases in vascularization during the injury-healing response, and mechanical compression and bending of bone during exercise. These conditions also induce changes in bone remodeling. Previously, we hypothesized that interstitial fluid flow in bone, and in particular fluid shear stress, serves to mediate signal transduction in mechanical loading- and injury-induced remodeling. In addition, we proposed that a lack or decrease of ISF flow results in the bone loss observed in disuse and microgravity. The purpose of this article is to review ISF flow in bone and its role in osteogenesis.

Experimental study on the signs of particulate structures formation in annular geometry of rapid granular shear flows

NASA Astrophysics Data System (ADS)

Ritvanen, J.; Jalali, P.

2009-06-01

Rapid granular shear flow is a classical example in granular materials which exhibits both fluid-like and solid-like behaviors. Another interesting feature of rapid granular shear flows is the formation of ordered structures upon shearing. Certain amount of granular material, with uniform size distribution, is required to be loaded in the container in order to shear it under stable conditions. This work concerns the experimental study of rapid granular shear flows in annular Couette geometry. The flow is induced by continuous rotation of the plate over the top of the granular bed in an annulus. The compressive pressure, driving torque, instantaneous bed height from three symmetric locations and rotational speed of the shearing plate are measured. The annulus has a capacity of up to 15 kg of spherical steel balls of 3 mm in diameter. Rapid shear flow experiments are performed in one compressive force and rotation rate. The sensitivity of fluctuations is then investigated by different means through monodisperse packing. In this work, we present the results of the experiments showing how the flow properties depend on the amount of loaded granular material which is varied by small amounts between different experiments. The flow can exist in stable (fixed behavior) and unstable (time-dependent behavior) regimes as a function of the loaded material. We present the characteristics of flow to detect the formation of any additional structured layer in the annulus. As a result, an evolution graph for the bed height has been obtained as material is gradually added. This graph shows how the bed height grows when material increases. Using these results, the structure inside the medium can be estimated at extreme stable and unstable conditions.

Toward an optimal design principle in symmetric and asymmetric tree flow networks.

PubMed

Miguel, Antonio F

2016-01-21

Fluid flow in tree-shaped networks plays an important role in both natural and engineered systems. This paper focuses on laminar flows of Newtonian and non-Newtonian power law fluids in symmetric and asymmetric bifurcating trees. Based on the constructal law, we predict the tree-shaped architecture that provides greater access to the flow subjected to the total network volume constraint. The relationships between the sizes of parent and daughter tubes are presented both for symmetric and asymmetric branching tubes. We also approach the wall-shear stresses and the flow resistance in terms of first tube size, degree of asymmetry between daughter branches, and rheological behavior of the fluid. The influence of tubes obstructing the fluid flow is also accounted for. The predictions obtained by our theory-driven approach find clear support in the findings of previous experimental studies. Copyright © 2015 Elsevier Ltd. All rights reserved.

Modelling the fluid mechanics of cilia and flagella in reproduction and development.

PubMed

Montenegro-Johnson, Thomas D; Smith, Andrew A; Smith, David J; Loghin, Daniel; Blake, John R

2012-10-01

Cilia and flagella are actively bending slender organelles, performing functions such as motility, feeding and embryonic symmetry breaking. We review the mechanics of viscous-dominated microscale flow, including time-reversal symmetry, drag anisotropy of slender bodies, and wall effects. We focus on the fundamental force singularity, higher-order multipoles, and the method of images, providing physical insight and forming a basis for computational approaches. Two biological problems are then considered in more detail: 1) left-right symmetry breaking flow in the node, a microscopic structure in developing vertebrate embryos, and 2) motility of microswimmers through non-Newtonian fluids. Our model of the embryonic node reveals how particle transport associated with morphogenesis is modulated by the gradual emergence of cilium posterior tilt. Our model of swimming makes use of force distributions within a body-conforming finite-element framework, allowing the solution of nonlinear inertialess Carreau flow. We find that a three-sphere model swimmer and a model sperm are similarly affected by shear-thinning; in both cases swimming due to a prescribed beat is enhanced by shear-thinning, with optimal Deborah number around 0.8. The sperm exhibits an almost perfect linear relationship between velocity and the logarithm of the ratio of zero to infinite shear viscosity, with shear-thickening hindering cell progress.

Shear-enhanced compaction bands formed at shallow burial conditions; implications for fluid flow (Provence, France)

NASA Astrophysics Data System (ADS)

Ballas, Gregory; Soliva, Roger; Sizun, Jean-Pierre; Fossen, Haakon; Benedicto, Antonio; Skurtveit, Elin

2013-02-01

Field observations of highly porous and permeable sandstone in the Orange area (S-E Basin, France) show that networks of shear-enhanced compaction bands can form in a contractional regime at burial depths of about 400 m ± 100 m. These bands show equal compaction and shear displacements, are organized in conjugate and densely distributed networks, and are restricted to the coarse-grained (mean grain diameter of 0.6 ± 0.1 mm) and less porous (porosity of 26 ± 2%) sand layers. The bands are crush microbreccia with limited grain comminution and high grain microfracture density. They show reductions of permeability (mD) ranging from 0 to little more than 1 order of magnitude. They show no control on the alteration products related to meteoric water flow, which suggests that these shear-enhanced compaction bands have no or only negligible influence on subsurface fluid flow. Their selective occurrence and small (20%) reduction in transmissibility in densely populated layers prevented them from compartmentalizing the sandstone reservoirs. A comparison with compaction-band populations in the Navajo and Aztec sandtsones (western U.S.) emphasizes the role of burial depth and the presence of chemical compaction processes for the sealing potential of deformation bands.

Development and Characterization of a Parallelizable Perfusion Bioreactor for 3D Cell Culture.

PubMed

Egger, Dominik; Fischer, Monica; Clementi, Andreas; Ribitsch, Volker; Hansmann, Jan; Kasper, Cornelia

2017-05-25

The three dimensional (3D) cultivation of stem cells in dynamic bioreactor systems is essential in the context of regenerative medicine. Still, there is a lack of bioreactor systems that allow the cultivation of multiple independent samples under different conditions while ensuring comprehensive control over the mechanical environment. Therefore, we developed a miniaturized, parallelizable perfusion bioreactor system with two different bioreactor chambers. Pressure sensors were also implemented to determine the permeability of biomaterials which allows us to approximate the shear stress conditions. To characterize the flow velocity and shear stress profile of a porous scaffold in both bioreactor chambers, a computational fluid dynamics analysis was performed. Furthermore, the mixing behavior was characterized by acquisition of the residence time distributions. Finally, the effects of the different flow and shear stress profiles of the bioreactor chambers on osteogenic differentiation of human mesenchymal stem cells were evaluated in a proof of concept study. In conclusion, the data from computational fluid dynamics and shear stress calculations were found to be predictable for relative comparison of the bioreactor geometries, but not for final determination of the optimal flow rate. However, we suggest that the system is beneficial for parallel dynamic cultivation of multiple samples for 3D cell culture processes.

Development and Characterization of a Parallelizable Perfusion Bioreactor for 3D Cell Culture

PubMed Central

Egger, Dominik; Fischer, Monica; Clementi, Andreas; Ribitsch, Volker; Hansmann, Jan; Kasper, Cornelia

2017-01-01

The three dimensional (3D) cultivation of stem cells in dynamic bioreactor systems is essential in the context of regenerative medicine. Still, there is a lack of bioreactor systems that allow the cultivation of multiple independent samples under different conditions while ensuring comprehensive control over the mechanical environment. Therefore, we developed a miniaturized, parallelizable perfusion bioreactor system with two different bioreactor chambers. Pressure sensors were also implemented to determine the permeability of biomaterials which allows us to approximate the shear stress conditions. To characterize the flow velocity and shear stress profile of a porous scaffold in both bioreactor chambers, a computational fluid dynamics analysis was performed. Furthermore, the mixing behavior was characterized by acquisition of the residence time distributions. Finally, the effects of the different flow and shear stress profiles of the bioreactor chambers on osteogenic differentiation of human mesenchymal stem cells were evaluated in a proof of concept study. In conclusion, the data from computational fluid dynamics and shear stress calculations were found to be predictable for relative comparison of the bioreactor geometries, but not for final determination of the optimal flow rate. However, we suggest that the system is beneficial for parallel dynamic cultivation of multiple samples for 3D cell culture processes. PMID:28952530

Bicuspid aortic valve hemodynamics: a fluid-structure interaction study

NASA Astrophysics Data System (ADS)

Chandra, Santanu; Seaman, Clara; Sucosky, Philippe

2011-11-01

The bicuspid aortic valve (BAV) is a congenital defect in which the aortic valve forms with two leaflets instead of three. While calcific aortic valve disease (CAVD) also develops in the normal tricuspid aortic valve (TAV), its progression in the BAV is more rapid. Although studies have suggested a mechano-potential root for the disease, the native BAV hemodynamics remains largely unknown. This study aimed at characterizing BAV hemodynamics and quantifying the degree of wall-shear stress (WSS) abnormality on BAV leaflets. Fluid-structure interaction models validated with particle-image velocimetry were designed to predict the flow and leaflet dynamics in idealized TAV and BAV anatomies. Valvular function was quantified in terms of the effective orifice area. The regional leaflet WSS was characterized in terms of oscillatory shear index, temporal shear magnitude and temporal shear gradient. The predictions indicate the intrinsic degree of stenosis of the BAV anatomy, reveal drastic differences in shear stress magnitude and pulsatility on BAV and TAV leaflets and confirm the side- and site-specificity of the leaflet WSS. Given the ability of abnormal fluid shear stress to trigger valvular inflammation, these results support the existence of a mechano-etiology of CAVD in the BAV.

Ca(2+) regulates fluid shear-induced cytoskeletal reorganization and gene expression in osteoblasts

NASA Technical Reports Server (NTRS)

Chen, N. X.; Ryder, K. D.; Pavalko, F. M.; Turner, C. H.; Burr, D. B.; Qiu, J.; Duncan, R. L.

2000-01-01

Osteoblasts subjected to fluid shear increase the expression of the early response gene, c-fos, and the inducible isoform of cyclooxygenase, COX-2, two proteins linked to the anabolic response of bone to mechanical stimulation, in vivo. These increases in gene expression are dependent on shear-induced actin stress fiber formation. Here, we demonstrate that MC3T3-E1 osteoblast-like cells respond to shear with a rapid increase in intracellular Ca(2+) concentration ([Ca(2+)](i)) that we postulate is important to subsequent cellular responses to shear. To test this hypothesis, MC3T3-E1 cells were grown on glass slides coated with fibronectin and subjected to laminar fluid flow (12 dyn/cm(2)). Before application of shear, cells were treated with two Ca(2+) channel inhibitors or various blockers of intracellular Ca(2+) release for 0. 5-1 h. Although gadolinium, a mechanosensitive channel blocker, significantly reduced the [Ca(2+)](i) response, neither gadolinium nor nifedipine, an L-type channel Ca(2+) channel blocker, were able to block shear-induced stress fiber formation and increase in c-fos and COX-2 in MC3T3-E1 cells. However, 1, 2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid-AM, an intracellular Ca(2+) chelator, or thapsigargin, which empties intracellular Ca(2+) stores, completely inhibited stress fiber formation and c-fos/COX-2 production in sheared osteoblasts. Neomycin or U-73122 inhibition of phospholipase C, which mediates D-myo-inositol 1,4,5-trisphosphate (IP(3))-induced intracellular Ca(2+) release, also completely suppressed actin reorganization and c-fos/COX-2 production. Pretreatment of MC3T3-E1 cells with U-73343, the inactive isoform of U-73122, did not inhibit these shear-induced responses. These results suggest that IP(3)-mediated intracellular Ca(2+) release is required for modulating flow-induced responses in MC3T3-E1 cells.

Fracture, fluid flow and paleostress at Sunrise Dam Gold Mine, W. Australia

NASA Astrophysics Data System (ADS)

Blenkinsop, Thomas; Sanderson, David; Nugus, Michael

2017-04-01

Some of the clearest examples of Interactions between fracture, fluid flow, pore fluid pressure and differential stress can be inferred from underground observations in mines. This study examines the inferred stress conditions and resulting fracture network that constitutes a stockwork type ore body at Sunrise Dam gold mine, Western Australia. Stockworks in mine workings are particularly instructive for such analyses, because the abundance of veins allows cross-cutting relationships to be observed, which are commonly hard to see in situations of lower fracture intensity or incomplete outcrop. Sunrise Dam has produced in excess of 8.5Moz of gold since 1989, with current Mineral Resources and Ore Reserves at 58.96Mt@2.41g/t Au (4.55Moz) and 21.45Mt@1.87g/t Au (1.29Moz), respectively. The stockwork examined is in the Astro ore body, and consists of three sets of extensional veins and one set of low-angle strike-slip shear veins. Cross-cutting relationships suggest broadly contemporaneous formation of all fracture sets, which are also related by a common quartz-carbonate mineralogy. The extensional veins intersect the shear veins along the direction of shear, a geometry that can be predicted for certain stress ratios. Combined with observations and paleostress inferences from other parts of the mine, the veining and gold mineralisation can be associated with a D4 strike-slip shearing event, which had a maximum compressive stress plunging gently NE. Fracture intensity varies by 50% on a scale of 10s of metres. The stockwork formed by repeated extensional and shear failure events, showing fluctuations in pore fluid pressure and stress conditions, which would have required fracture healing/sealing in order for the deformation to spread throughout the stockwork volume.

Impact of E × B shear flow on low-n MHD instabilities.

PubMed

Chen, J G; Xu, X Q; Ma, C H; Xi, P W; Kong, D F; Lei, Y A

2017-05-01

Recently, the stationary high confinement operations with improved pedestal conditions have been achieved in DIII-D [K. H. Burrell et al. , Phys. Plasmas 23 , 056103 (2016)], accompanying the spontaneous transition from the coherent edge harmonic oscillation (EHO) to the broadband MHD turbulence state by reducing the neutral beam injection torque to zero. It is highly significant for the burning plasma devices such as ITER. Simulations about the effects of E  ×  B shear flow on the quiescent H-mode (QH-mode) are carried out using the three-field two-fluid model in the field-aligned coordinate under the BOUT++ framework. Using the shifted circular cross-section equilibriums including bootstrap current, the results demonstrate that the E  ×  B shear flow strongly destabilizes low-n peeling modes, which are mainly driven by the gradient of parallel current in peeling-dominant cases and are sensitive to the E r shear. Adopting the much more general shape of E  ×  B shear ([Formula: see text]) profiles, the linear and nonlinear BOUT++ simulations show qualitative consistence with the experiments. The stronger shear flow shifts the most unstable mode to lower-n and narrows the mode spectrum. At the meantime, the nonlinear simulations of the QH-mode indicate that the shear flow in both co- and counter directions of diamagnetic flow has some similar effects. The nonlinear mode interaction is enhanced during the mode amplitude saturation phase. These results reveal that the fundamental physics mechanism of the QH-mode may be shear flow and are significant for understanding the mechanism of EHO and QH-mode.

Impact of E × B shear flow on low-n MHD instabilities

NASA Astrophysics Data System (ADS)

Chen, J. G.; Xu, X. Q.; Ma, C. H.; Xi, P. W.; Kong, D. F.; Lei, Y. A.

2017-05-01

Recently, the stationary high confinement operations with improved pedestal conditions have been achieved in DIII-D [K. H. Burrell et al., Phys. Plasmas 23, 056103 (2016)], accompanying the spontaneous transition from the coherent edge harmonic oscillation (EHO) to the broadband MHD turbulence state by reducing the neutral beam injection torque to zero. It is highly significant for the burning plasma devices such as ITER. Simulations about the effects of E × B shear flow on the quiescent H-mode (QH-mode) are carried out using the three-field two-fluid model in the field-aligned coordinate under the BOUT++ framework. Using the shifted circular cross-section equilibriums including bootstrap current, the results demonstrate that the E × B shear flow strongly destabilizes low-n peeling modes, which are mainly driven by the gradient of parallel current in peeling-dominant cases and are sensitive to the Er shear. Adopting the much more general shape of E × B shear ( ω E = E r / R B θ ) profiles, the linear and nonlinear BOUT++ simulations show qualitative consistence with the experiments. The stronger shear flow shifts the most unstable mode to lower-n and narrows the mode spectrum. At the meantime, the nonlinear simulations of the QH-mode indicate that the shear flow in both co- and counter directions of diamagnetic flow has some similar effects. The nonlinear mode interaction is enhanced during the mode amplitude saturation phase. These results reveal that the fundamental physics mechanism of the QH-mode may be shear flow and are significant for understanding the mechanism of EHO and QH-mode.

Impact of E × B shear flow on low-n MHD instabilities

PubMed Central

Chen, J. G.; Ma, C. H.; Xi, P. W.; Lei, Y. A.

2017-01-01

Recently, the stationary high confinement operations with improved pedestal conditions have been achieved in DIII-D [K. H. Burrell et al., Phys. Plasmas 23, 056103 (2016)], accompanying the spontaneous transition from the coherent edge harmonic oscillation (EHO) to the broadband MHD turbulence state by reducing the neutral beam injection torque to zero. It is highly significant for the burning plasma devices such as ITER. Simulations about the effects of E × B shear flow on the quiescent H-mode (QH-mode) are carried out using the three-field two-fluid model in the field-aligned coordinate under the BOUT++ framework. Using the shifted circular cross-section equilibriums including bootstrap current, the results demonstrate that the E × B shear flow strongly destabilizes low-n peeling modes, which are mainly driven by the gradient of parallel current in peeling-dominant cases and are sensitive to the Er shear. Adopting the much more general shape of E × B shear (ωE=Er/RBθ) profiles, the linear and nonlinear BOUT++ simulations show qualitative consistence with the experiments. The stronger shear flow shifts the most unstable mode to lower-n and narrows the mode spectrum. At the meantime, the nonlinear simulations of the QH-mode indicate that the shear flow in both co- and counter directions of diamagnetic flow has some similar effects. The nonlinear mode interaction is enhanced during the mode amplitude saturation phase. These results reveal that the fundamental physics mechanism of the QH-mode may be shear flow and are significant for understanding the mechanism of EHO and QH-mode. PMID:28579732

International Conference on Numerical Methods in Fluid Dynamics, 7th, Stanford University, Stanford and Moffett Field, CA, June 23-27, 1980, Proceedings

NASA Technical Reports Server (NTRS)

Reynolds, W. C. (Editor); Maccormack, R. W.

1981-01-01

Topics discussed include polygon transformations in fluid mechanics, computation of three-dimensional horseshoe vortex flow using the Navier-Stokes equations, an improved surface velocity method for transonic finite-volume solutions, transonic flow calculations with higher order finite elements, the numerical calculation of transonic axial turbomachinery flows, and the simultaneous solutions of inviscid flow and boundary layer at transonic speeds. Also considered are analytical solutions for the reflection of unsteady shock waves and relevant numerical tests, reformulation of the method of characteristics for multidimensional flows, direct numerical simulations of turbulent shear flows, the stability and separation of freely interacting boundary layers, computational models of convective motions at fluid interfaces, viscous transonic flow over airfoils, and mixed spectral/finite difference approximations for slightly viscous flows.

Water pumping in mantle shear zones

PubMed Central

Précigout, Jacques; Prigent, Cécile; Palasse, Laurie; Pochon, Anthony

2017-01-01

Water plays an important role in geological processes. Providing constraints on what may influence the distribution of aqueous fluids is thus crucial to understanding how water impacts Earth's geodynamics. Here we demonstrate that ductile flow exerts a dynamic control on water-rich fluid circulation in mantle shear zones. Based on amphibole distribution and using dislocation slip-systems as a proxy for syn-tectonic water content in olivine, we highlight fluid accumulation around fine-grained layers dominated by grain-size-sensitive creep. This fluid aggregation correlates with dislocation creep-accommodated strain that localizes in water-rich layers. We also give evidence of cracking induced by fluid pressure where the highest amount of water is expected. These results emphasize long-term fluid pumping attributed to creep cavitation and associated phase nucleation during grain size reduction. Considering the ubiquitous process of grain size reduction during strain localization, our findings shed light on multiple fluid reservoirs in the crust and mantle. PMID:28593947

A novel rheo-optical device for studying complex fluids in a double shear plate geometry.

PubMed

Boitte, Jean-Baptiste; Vizcaïno, Claude; Benyahia, Lazhar; Herry, Jean-Marie; Michon, Camille; Hayert, Murielle

2013-01-01

A new rheo-optical shearing device was designed to investigate the structural evolution of complex material under shear flow. Seeking to keep the area under study constantly within the field of vision, it was conceived to produce shear flow by relying on the uniaxial translation of two parallel plates. The device features three modes of translation motion: step strain (0.02-320), constant shear rate (0.01-400 s(-1)), and oscillation (0.01-20 Hz) flow. Because the temperature is controlled by using a Peltier module coupled with a water cooling system, temperatures can range from 10 to 80 °C. The sample is loaded onto a user-friendly plate on which standard glasses can be attached with a depression vacuum pump. The principle innovation of the proposed rheo-optical shearing device lies in the fact that this suction system renders the microscopy glasses one with the plates, thereby ensuring their perfect planarity and parallelism. The gap width between the two plates can range from 0 to 5 mm. The device was designed to fit on any inverted confocal laser scanning microscope. In terms of controlled deformation, the conception and technical solutions achieve a high level of accuracy. Moreover, user-friendly software has been developed to control both shear flow parameters and temperature. The validation of specifications as well as the three modes of motion was carried out, first of all without a sample, and then by tracking fluorescent particles in a model system, in our case a micro-gel. Real values agreed well with those we targeted. In addition, an experiment with bread dough deformation under shear flow was initiated to gain some insight into the potential use of our device. These results show that the RheOptiCAD(®) promises to be a useful tool to better understand, from both a fundamental and an industrial point of view, the rheological behavior of the microstructure of complex fluids under controlled thermo-mechanical parameters in the case of food and non-food systems.

A novel rheo-optical device for studying complex fluids in a double shear plate geometry

NASA Astrophysics Data System (ADS)

Boitte, Jean-Baptiste; Vizcaïno, Claude; Benyahia, Lazhar; Herry, Jean-Marie; Michon, Camille; Hayert, Murielle

2013-01-01

A new rheo-optical shearing device was designed to investigate the structural evolution of complex material under shear flow. Seeking to keep the area under study constantly within the field of vision, it was conceived to produce shear flow by relying on the uniaxial translation of two parallel plates. The device features three modes of translation motion: step strain (0.02-320), constant shear rate (0.01-400 s-1), and oscillation (0.01-20 Hz) flow. Because the temperature is controlled by using a Peltier module coupled with a water cooling system, temperatures can range from 10 to 80 °C. The sample is loaded onto a user-friendly plate on which standard glasses can be attached with a depression vacuum pump. The principle innovation of the proposed rheo-optical shearing device lies in the fact that this suction system renders the microscopy glasses one with the plates, thereby ensuring their perfect planarity and parallelism. The gap width between the two plates can range from 0 to 5 mm. The device was designed to fit on any inverted confocal laser scanning microscope. In terms of controlled deformation, the conception and technical solutions achieve a high level of accuracy. Moreover, user-friendly software has been developed to control both shear flow parameters and temperature. The validation of specifications as well as the three modes of motion was carried out, first of all without a sample, and then by tracking fluorescent particles in a model system, in our case a micro-gel. Real values agreed well with those we targeted. In addition, an experiment with bread dough deformation under shear flow was initiated to gain some insight into the potential use of our device. These results show that the RheOptiCAD® promises to be a useful tool to better understand, from both a fundamental and an industrial point of view, the rheological behavior of the microstructure of complex fluids under controlled thermo-mechanical parameters in the case of food and non-food systems.

A fluid–structure interaction model to characterize bone cell stimulation in parallel-plate flow chamber systems

PubMed Central

Vaughan, T. J.; Haugh, M. G.; McNamara, L. M.

2013-01-01

Bone continuously adapts its internal structure to accommodate the functional demands of its mechanical environment and strain-induced flow of interstitial fluid is believed to be the primary mediator of mechanical stimuli to bone cells in vivo. In vitro investigations have shown that bone cells produce important biochemical signals in response to fluid flow applied using parallel-plate flow chamber (PPFC) systems. However, the exact mechanical stimulus experienced by the cells within these systems remains unclear. To fully understand this behaviour represents a most challenging multi-physics problem involving the interaction between deformable cellular structures and adjacent fluid flows. In this study, we use a fluid–structure interaction computational approach to investigate the nature of the mechanical stimulus being applied to a single osteoblast cell under fluid flow within a PPFC system. The analysis decouples the contribution of pressure and shear stress on cellular deformation and for the first time highlights that cell strain under flow is dominated by the pressure in the PPFC system rather than the applied shear stress. Furthermore, it was found that strains imparted on the cell membrane were relatively low whereas significant strain amplification occurred at the cell–substrate interface. These results suggest that strain transfer through focal attachments at the base of the cell are the primary mediators of mechanical signals to the cell under flow in a PPFC system. Such information is vital in order to correctly interpret biological responses of bone cells under in vitro stimulation and elucidate the mechanisms associated with mechanotransduction in vivo. PMID:23365189

Properties of two-fluid flowing equilibria observed in double-pulsing coaxial helicity injection on HIST

NASA Astrophysics Data System (ADS)

Kanki, T.; Nagata, M.

2013-10-01

Multi-pulsing coaxial helicity injection (M-CHI) method which aims to achieve both quasi-steady sustainment and good confinement has been proposed as a refluxing scenario of the CHI. To explore the usefulness of the M-CHI for spherical torus (ST) configurations, the double-pulsing operations have been carried out in the HIST, verifying the flux amplification and the formation of the closed flux surfaces after the second CHI pulse. The purpose of this study is to investigate the properties of the magnetic field and plasma flow structures during the sustainment by comparing the results of plasma flow, density, and magnetic fields measurements with those of two-fluid equilibrium calculations. The two-fluid flowing equilibrium model which is described by a pair of generalized Grad-Shafranov equations for ion and electron surface variables and Bernoulli equations for density is applied to reconstruct the ST configuration with poloidal flow shear observed in the HIST. Due to the negative steep density gradient in high field side, the toroidal field has a diamagnetic profile (volume average beta, < β > = 68 %) in the central open flux column region. The ion flow velocity with strong flow shear from the separatrix in the inboard side to the core region is the opposite direction to the electron flow velocity due to the diamagentic drift through the density gradient. The electric field is relatively small in the whole region, and thus the Lorentz force nearly balances with the two-fluid effect which is particularly significant in a region with the steep density gradient due to the ion and electron diamagnetic drifts.

Creep cavitation can establish a dynamic granular fluid pump in ductile shear zones.

PubMed

Fusseis, F; Regenauer-Lieb, K; Liu, J; Hough, R M; De Carlo, F

2009-06-18

The feedback between fluid migration and rock deformation in mid-crustal shear zones is acknowledged as being critical for earthquake nucleation, the initiation of subduction zones and the formation of mineral deposits. The importance of this poorly understood feedback is further highlighted by evidence for shear-zone-controlled advective flow of fluids in the ductile lower crust and the recognition that deformation-induced grain-scale porosity is a key to large-scale geodynamics. Fluid migration in the middle crust cannot be explained in terms of classical concepts. The environment is considered too hot for a dynamic fracture-sustained permeability as in the upper crust, and fluid pathways are generally too deformed to be controlled by equilibrium wetting angles that apply to hotter, deeper environments. Here we present evidence that mechanical and chemical potentials control a syndeformational porosity generation in mid-crustal shear zones. High-resolution synchrotron X-ray tomography and scanning electron microscopy observations allow us to formulate a model for fluid migration in shear zones where a permeable porosity is dynamically created by viscous grain-boundary sliding, creep cavitation, dissolution and precipitation. We propose that syndeformational fluid migration in our 'granular fluid pump' model is a self-sustained process controlled by the explicit role of the rate of entropy production of the underlying irreversible mechanical and chemical microprocesses. The model explains fluid transfer through the middle crust, where strain localization in the creep regime is required for plate tectonics, the formation of giant ore deposits, mantle degassing and earthquake nucleation. Our findings provide a key component for the understanding of creep instabilities in the middle crust.

Empirical resistive-force theory for slender biological filaments in shear-thinning fluids

NASA Astrophysics Data System (ADS)

Riley, Emily E.; Lauga, Eric

2017-06-01

Many cells exploit the bending or rotation of flagellar filaments in order to self-propel in viscous fluids. While appropriate theoretical modeling is available to capture flagella locomotion in simple, Newtonian fluids, formidable computations are required to address theoretically their locomotion in complex, nonlinear fluids, e.g., mucus. Based on experimental measurements for the motion of rigid rods in non-Newtonian fluids and on the classical Carreau fluid model, we propose empirical extensions of the classical Newtonian resistive-force theory to model the waving of slender filaments in non-Newtonian fluids. By assuming the flow near the flagellum to be locally Newtonian, we propose a self-consistent way to estimate the typical shear rate in the fluid, which we then use to construct correction factors to the Newtonian local drag coefficients. The resulting non-Newtonian resistive-force theory, while empirical, is consistent with the Newtonian limit, and with the experiments. We then use our models to address waving locomotion in non-Newtonian fluids and show that the resulting swimming speeds are systematically lowered, a result which we are able to capture asymptotically and to interpret physically. An application of the models to recent experimental results on the locomotion of Caenorhabditis elegans in polymeric solutions shows reasonable agreement and thus captures the main physics of swimming in shear-thinning fluids.

Effect of simple shear flow on photosynthesis rate and morphology of micro algae

NASA Astrophysics Data System (ADS)

Mitsuhashi, S.; Fujimoto, M.; Muramatsu, H.; Tanishita, K.

The convective motion of micro algal suspension gives an advantageous effect on the photosynthetic rate in the bioreactor, however, the nature of convective effect on the photosynthesis has not been fully understood. The propose of this study concerns the nature of photosynthetic rate in a well-defined hydrodynamic shear flow of Spirulina platensis suspension, generated in a double rotating coaxial cylinders. The double rotating coaxial cylinders was installed in the incubator chamber with the controlled illumination intensity and temperature. Two kind of experiments, short and long term experiments, were performed to evaluate the direct effect of shear flow on the photosynthetic rate. The short term experiment indicates that the simple shear flow enables to augment the photosynthesis of Spirulina suspension and simultaneously causes the cell destruction due to the excessive shear stress. The long term experiment for 100 hours reveals that the growth rate and the morphology of Spirulina is sensitive to the external fluid mechanical stimulus. The long term application of mechanical stress on the algae may result in the adaptation of the photosynthetic function and morphology.

Blood Flow Modulation of Vascular Dynamics

PubMed Central

Lee, Juhyun; Sevag Packard, René R.; Hsiai, Tzung K.

2015-01-01

Purpose of review Blood flow is intimately linked with cardiovascular development, repair, and dysfunction. The current review will build on the fluid mechanical principle underlying hemodynamic shear forces, mechanotransduction, and metabolic effects. Recent findings Pulsatile flow produces both time- (∂τ /∂t)and spatial-varying shear stress (∂τ /∂x) to modulate vascular oxidative stress and inflammatory response with pathophysiological significance to atherosclerosis. The characteristics of hemodynamic shear forces; namely, steady laminar (∂τ /∂t= 0), pulsatile (PSS: unidirectional forward flow), and oscillatory shear stress (OSS: bidirectional with a near net 0 forward flow) modulate mechano-signal transduction to influence metabolic effects on vascular endothelial function. Atheroprotective PSS promotes anti-oxidant, anti-inflammatory, and anti-thrombotic responses, whereas atherogenic OSS induces NADPH oxidase–JNK signaling to increase mitochondrial superoxide production, protein degradation of manganese superoxide dismutase (MnSOD), and post-translational protein modifications of LDL particles in the disturbed flow-exposed regions of vasculature. In the era of tissue regeneration, shear stress has been implicated in re-activation of developmental genes; namely, Wnt and Notch signaling, for vascular development and repair. Summary Blood flow imparts a dynamic continuum from vascular development to repair. Augmentation of PSS confers atheroprotection and re-activation of developmental signaling pathways for regeneration. PMID:26218416

Homoclinic tangle on the edge of shear turbulence.

PubMed

van Veen, Lennaert; Kawahara, Genta

2011-09-09

Experiments and simulations lend mounting evidence for the edge state hypothesis on subcritical transition to turbulence, which asserts that simple states of fluid motion mediate between laminar and turbulent shear flow as their stable manifolds separate the two in state space. In this Letter we describe flows homoclinic to a time-periodic edge state that display the essential properties of turbulent bursting. During a burst, vortical structures and the associated energy dissipation are highly localized near the wall, in contrast with the familiar regeneration cycle.

Britle failure of non-Newtonian, floating, extensional flows

NASA Astrophysics Data System (ADS)

Sayag, Roiy; Worster, Michael

2011-11-01

Glacier ice is driven by gravity to flow from the land, where it is under shear, into the ocean, where it floats and extends. Owing to its non-Newtonian rheology, the ice can flow axisymmetrically over the bed but undergo brittle failure once it is floating on the ocean, as observed for example in crevassing of ice shelves. We model this coupled flow as an intrusion of a viscous gravity current into a denser ocean and study it both theoretically and experimentally. We have conducted laboratory experiments using a shear-thinning suspension that represents ice, and a denser inviscid fluid that represents an ocean. The non-Newtonian fluid was released at a constant flux through a cylindrical nozzle over a horizontal plane. The grounded, shear-dominated region of the flow was axisymmetric throughout the experiment, while past the transition line axisymmetry broke down into a seemingly ordered set of finger-like extensions (floating shelves) that demonstrated brittle behaviour. We have found that the width of the fingers as well as their radial extent increase with the flux. We attempt to explain these observations through a fingering instability that is driven by the dynamical differences between the two flow domains and by the material rheology, and we project that analysis to formulate a linkage between the material properties of ice and an upper bound on the width of ice shelves. NERC

Highly Permeable Silicon Membranes for Shear Free Chemotaxis and Rapid Cell Labeling

PubMed Central

Chung, Henry H.; Chan, Charles K.; Khire, Tejas S.; Marsh, Graham A.; Clark, Alfred; Waugh, Richard E.; McGrath, James L.

2015-01-01

Microfluidic systems are powerful tools for cell biology studies because they enable the precise addition and removal of solutes in small volumes. However, the fluid forces inherent in the use of microfluidics for cell cultures are sometimes undesirable. An important example is chemotaxis systems where fluid flow creates well-defined and steady chemotactic gradients but also pushes cells downstream. Here we demonstrate a chemotaxis system in which two chambers are separated by a molecularly thin (15 nm), transparent, and nanoporous silicon membrane. One chamber is a microfluidic channel that carries a flow-generated gradient while the other chamber is a shear-free environment for cell observation. The molecularly thin membranes provide effectively no resistance to molecular diffusion between the two chambers, making them ideal elements for creating flow-free chambers in microfluidic systems. Analytical and computational flow models that account for membrane and chamber geometry, predict shear reduction of more than five orders of magnitude. This prediction is confirmed by observing the pure diffusion of nanoparticles in the cell-hosting chamber despite high input flow (Q = 10 µL min−1; vavg ~45 mm min−1) in the flow chamber only 15 nm away. Using total internal reflection fluorescence (TIRF) microscopy, we show that a flow-generated molecular gradient will pass through the membrane into the quiescent cell chamber. Finally we demonstrate that our device allows us to expose migrating neutrophils to a chemotactic gradient or fluorescent label without any influence from flow. PMID:24850320

Stability, intermittency and universal Thorpe length distribution in a laboratory turbulent stratified shear flow

DOE Office of Scientific and Technical Information (OSTI.GOV)

Odier, Philippe; Ecke, Robert E.

Stratified shear flows occur in many geophysical contexts, from oceanic overflows and river estuaries to wind-driven thermocline layers. In this study, we explore a turbulent wall-bounded shear flow of lighter miscible fluid into a quiescent fluid of higher density with a range of Richardson numbersmore » $$0.05\\lesssim Ri\\lesssim 1$$. In order to find a stability parameter that allows close comparison with linear theory and with idealized experiments and numerics, we investigate different definitions of$Ri$$. We find that a gradient Richardson number defined on fluid interface sections where there is no overturning at or adjacent to the maximum density gradient position provides an excellent stability parameter, which captures the Miles–Howard linear stability criterion. For small $$Ri$$ the flow exhibits robust Kelvin–Helmholtz instability, whereas for larger $$Ri$$ interfacial overturning is more intermittent with less frequent Kelvin–Helmholtz events and emerging Holmboe wave instability consistent with a thicker velocity layer compared with the density layer. We compute the perturbed fraction of interface as a quantitative measure of the flow intermittency, which is approximately 1 for the smallest $$Ri$$ but decreases rapidly as $$Ri$ increases, consistent with linear theory. For the perturbed regions, we use the Thorpe scale to characterize the overturning properties of these flows. The probability distribution of the non-zero Thorpe length yields a universal exponential form, suggesting that much of the overturning results from increasingly intermittent Kelvin–Helmholtz instability events. Finally, the distribution of turbulent kinetic energy, conditioned on the intermittency fraction, has a similar form, suggesting an explanation for the universal scaling collapse of the Thorpe length distribution.« less

Stability, intermittency and universal Thorpe length distribution in a laboratory turbulent stratified shear flow

DOE PAGES

Odier, Philippe; Ecke, Robert E.

2017-02-21

Stratified shear flows occur in many geophysical contexts, from oceanic overflows and river estuaries to wind-driven thermocline layers. In this study, we explore a turbulent wall-bounded shear flow of lighter miscible fluid into a quiescent fluid of higher density with a range of Richardson numbersmore » $$0.05\\lesssim Ri\\lesssim 1$$. In order to find a stability parameter that allows close comparison with linear theory and with idealized experiments and numerics, we investigate different definitions of$Ri$$. We find that a gradient Richardson number defined on fluid interface sections where there is no overturning at or adjacent to the maximum density gradient position provides an excellent stability parameter, which captures the Miles–Howard linear stability criterion. For small $$Ri$$ the flow exhibits robust Kelvin–Helmholtz instability, whereas for larger $$Ri$$ interfacial overturning is more intermittent with less frequent Kelvin–Helmholtz events and emerging Holmboe wave instability consistent with a thicker velocity layer compared with the density layer. We compute the perturbed fraction of interface as a quantitative measure of the flow intermittency, which is approximately 1 for the smallest $$Ri$$ but decreases rapidly as $$Ri$ increases, consistent with linear theory. For the perturbed regions, we use the Thorpe scale to characterize the overturning properties of these flows. The probability distribution of the non-zero Thorpe length yields a universal exponential form, suggesting that much of the overturning results from increasingly intermittent Kelvin–Helmholtz instability events. Finally, the distribution of turbulent kinetic energy, conditioned on the intermittency fraction, has a similar form, suggesting an explanation for the universal scaling collapse of the Thorpe length distribution.« less

Rheological properties of simulated debris flows in the laboratory environment

USGS Publications Warehouse

Ling, Chi-Hai; Chen, Cheng-lung; Jan, Chyan-Deng; ,

1990-01-01

Steady debris flows with or without a snout are simulated in a 'conveyor-belt' flume using dry glass spheres of a uniform size, 5 or 14 mm in diameter, and their rheological properties described quantitatively in constants in a generalized viscoplastic fluid (GVF) model. Close agreement of the measured velocity profiles with the theoretical ones obtained from the GVF model strongly supports the validity of a GVF model based on the continuum-mechanics approach. Further comparisons of the measured and theoretical velocity profiles along with empirical relations among the shear stress, the normal stress, and the shear rate developed from the 'ring-shear' apparatus determine the values of the rheological parameters in the GVF model, namely the flow-behavior index, the consistency index, and the cross-consistency index. Critical issues in the evaluation of such rheological parameters using the conveyor-belt flume and the ring-shear apparatus are thus addressed in this study.

Turbulence in Compressible Flows

NASA Technical Reports Server (NTRS)

1997-01-01

Lecture notes for the AGARD Fluid Dynamics Panel (FDP) Special Course on 'Turbulence in Compressible Flows' have been assembled in this report. The following topics were covered: Compressible Turbulent Boundary Layers, Compressible Turbulent Free Shear Layers, Turbulent Combustion, DNS/LES and RANS Simulations of Compressible Turbulent Flows, and Case Studies of Applications of Turbulence Models in Aerospace.

Viscous grounding lines

NASA Astrophysics Data System (ADS)

Worster, Grae; Huppert, Herbert; Robison, Rosalyn; Nandkishore, Rahul; Rajah, Luke

2008-11-01

We have used simple laboratory experiments with viscous fluids to explore the dynamics of grounding lines between Antarctic marine ice sheets and the freely floating ice shelves into which they develop. Ice sheets are shear-dominated gravity currents, while ice shelves are extensional gravity currents with zero shear to leading order. Though ice sheets have non-Newtonian rheology, fundamental aspects of their flow can be explored using Newtonian fluid mechanics. We have derived a mathematical model of this flow that incorporates a new dynamic boundary condition for the position of the grounding line, where the gravity current loses contact with the solid base. Good agreement between our theoretical predictions and our experimental measurements, made using gravity currents of syrup flowing down a rigid slope into a deep, dense salt solution, gives confidence in the fundamental assumptions of our model, which can be incorporated into shallow-ice models to make important predictions regarding the dynamical stability of marine ice sheets.

Elastic turbulence in entangled semi-dilute DNA solutions measured with optical coherence tomography velocimetry.

PubMed

Malm, A V; Waigh, T A

2017-04-26

The flow instabilities of solutions of high molecular weight DNA in the entangled semi-dilute concentration regime were investigated using optical coherence tomography velocimetry, a technique that provides high spatial (probe volumes of 3.4 pL) and temporal resolution (sub μs) information on the flow behaviour of complex fluids in a rheometer. The velocity profiles of the opaque DNA solutions (high and low salt) were measured as a function of the distance across the gap of a parallel plate rheometer, and their evolution over time was measured. At lower DNA concentrations and low shear rates, the velocity fluctuations were well described by Gaussian functions and the velocity gradient was uniform across the rheometer gap, which is expected for Newtonian flows. As the DNA concentration and shear rate were increased there was a stable wall slip regime followed by an evolving wall slip regime, which is finally followed by the onset of elastic turbulence. Strain localization (shear banding) is observed on the boundaries of the flows at intermediate shear rates, but decreases in the high shear elastic turbulence regime, where bulk strain localization occurs. A dynamic phase diagram for non-linear flow was created to describe the different behaviours.

Effects of fluid shear stress on polyelectrolyte multilayers by neutron scattering studies

DOE PAGES

Singh, Saurabh; Junghans, Ann; Watkins, Erik; ...

2015-02-17

The structure of layer-by-layer (LbL) deposited nanofilm coatings consists of alternating polyethylenimine (PEI) and polystyrenesulfonate (PSS) films deposited on a single crystal quartz substrate. LbL-deposited nanofilms were investigated by neutron reflectomery (NR) in contact with water in the static and fluid shear stress conditions. The fluid shear stress was applied through a laminar flow of the liquid parallel to the quartz/polymer interface in a custom-built solid–liquid interface cell. The scattering length density profiles obtained from NR results of these polyelectrolyte multilayers (PEM), measured under different shear conditions, showed proportional decrease of volume fraction of water hydrating the polymers. For themore » highest shear rate applied (ca. 6800 s –1) the water volume fraction decreased by approximately 7%. The decrease of the volume fraction of water was homogeneous through the thickness of the film. Since there were not any significant changes in the total polymer thickness, it resulted in negative osmotic pressures in the film. The PEM films were compared with the behavior of thin films of thermoresponsive poly(N-isopropylacrylamide) (pNIPAM) deposited via spin-coating. The PEM and pNIPAM differ in their interactions with water molecules, and they showed opposite behaviors under the fluid shear stress. In both cases the polymer hydration was reversible upon the restoration of static conditions. Furthermore, a theoretical explanation is given to explain this difference in the effect of shear on hydration of polymeric thin films.« less

Impact of competitive flow on wall shear stress in coronary surgery: computational fluid dynamics of a LIMA-LAD model.

PubMed

Nordgaard, Håvard; Swillens, Abigail; Nordhaug, Dag; Kirkeby-Garstad, Idar; Van Loo, Denis; Vitale, Nicola; Segers, Patrick; Haaverstad, Rune; Lovstakken, Lasse

2010-12-01

Competitive flow from native coronary vessels is considered a major factor in the failure of coronary bypass grafts. However, the pathophysiological effects are not fully understood. Low and oscillatory wall shear stress (WSS) is known to induce endothelial dysfunction and vascular disease, like atherosclerosis and intimal hyperplasia. The aim was to investigate the impact of competitive flow on WSS in mammary artery bypass grafts. Using computational fluid dynamics, WSS was calculated in a left internal mammary artery (LIMA) graft to the left anterior descending artery in a three-dimensional in vivo porcine coronary artery bypass graft model. The following conditions were investigated: high competitive flow (non-significant coronary lesion), partial competitive flow (significant coronary lesion), and no competitive flow (totally occluded coronary vessel). Time-averaged WSS of LIMA at high, partial, and no competitive flow were 0.3-0.6, 0.6-3.0, and 0.9-3.0 Pa, respectively. Further, oscillatory WSS quantified as the oscillatory shear index (OSI) ranged from (maximum OSI = 0.5 equals zero net WSS) 0.15 to 0.35, <0.05, and <0.05, respectively. Thus, high competitive flow resulted in substantial oscillatory and low WSS. Moderate competitive flow resulted in WSS and OSI similar to the no competitive flow condition. Graft flow is highly dependent on the degree of competitive flow. High competitive flow was found to produce unfavourable WSS consistent with endothelial dysfunction and subsequent graft narrowing and failure. Partial competitive flow, however, may be better tolerated as it was found to be similar to the ideal condition of no competitive flow.

Flow-induced corrosion behavior of absorbable magnesium-based stents.

PubMed

Wang, Juan; Giridharan, Venkataraman; Shanov, Vesselin; Xu, Zhigang; Collins, Boyce; White, Leon; Jang, Yongseok; Sankar, Jagannathan; Huang, Nan; Yun, Yeoheung

2014-12-01

The aim of this work was to study corrosion behavior of magnesium (Mg) alloys (MgZnCa plates and AZ31 stents) under varied fluid flow conditions representative of the vascular environment. Experiments revealed that fluid hydrodynamics, fluid flow velocity and shear stress play essential roles in the corrosion behavior of absorbable magnesium-based stent devices. Flow-induced shear stress (FISS) accelerates the overall corrosion (including localized, uniform, pitting and erosion corrosions) due to the increased mass transfer and mechanical force. FISS increased the average uniform corrosion rate, the localized corrosion coverage ratios and depths and the removal rate of corrosion products inside the corrosion pits. For MgZnCa plates, an increase of FISS results in an increased pitting factor but saturates at an FISS of ∼0.15Pa. For AZ31 stents, the volume loss ratio (31%) at 0.056Pa was nearly twice that (17%) at 0Pa before and after corrosion. Flow direction has a significant impact on corrosion behavior as more severe pitting and erosion corrosion was observed on the back ends of the MgZnCa plates, and the corrosion product layer facing the flow direction peeled off from the AZ31 stent struts. This study demonstrates that flow-induced corrosion needs be understood so that Mg-based stents in vascular environments can be effectively designed. Copyright © 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Cyclic variation of ultrasonic backscattering from porcine whole blood under pulsatile flow

NASA Astrophysics Data System (ADS)

Lin, Yu-Hong

1997-10-01

The cyclic variation of ultrasonic backscattering from blood under pulsatile flow is believed to be related to the change of aggregation state of red cells and is only observed in whole blood. This study was to investigate the phenomenon by an invasive approach which was performed by inserting a 10 MHz catheter mounted transducer into a vessel. For ultrasonic measurement from blood, the most fundamental scheme is the hematocrit dependence. The backscatter maximum location was changed as the blood was stirred or stationary, as well as under steady laminar or turbulent flows. The same trend was also observed under pulsatile flow with 10% to 50% hematocrits in this study, as the backscattering to hematocrit curves were plotted at different times during a flow cycle. When the cyclic variation at 20 beats per minute (BPM) was interpreted in time domain, the enhanced aggregation at the beginning of shearing was observed. At 20 BPM with 40% hematocrit, the amplitude of cyclic variation was reduced when the shear rate was increased and the threshold of 150 s-1 was estimated. The results showed that there was no cyclic variation at 60 BPM. The backscattering was also plotted against the mean flow velocity, which demonstrated the hysteresis loops. The ultrasonic measurements showed that the relationship between the forward and backward paths of the loops were altered as beat rate, hematocrit, and shear rate were varied. Since the pulsatile flow was very complicated, a computational fluid dynamics package, FIDAPTM, was used to compute the shear rate based on the Power Law Model for non-Newtonian fluid viscosity. The non- Newtonian index and consistency in the model were computed from the viscosity to shear rate curves at 10% to 50% hematocrits measured by a cone-plate viscometer. For in vivo measurements, small pigs were used as models. Ultrasonic backscattering measurements were performed in the arteries and veins. The effect of stenosis was also investigated at the site below the renal branch in the artery. The results show that the cyclic variation from whole blood was mediated by the shear rate, hematocrit, beat rate, and fibrinogen concentration.

The effect of non-Newtonian viscosity on the stability of the Blasius boundary layer

NASA Astrophysics Data System (ADS)

Griffiths, P. T.; Gallagher, M. T.; Stephen, S. O.

2016-07-01

We consider, for the first time, the stability of the non-Newtonian boundary layer flow over a flat plate. Shear-thinning and shear-thickening flows are modelled using a Carreau constitutive viscosity relationship. The boundary layer equations are solved in a self-similar fashion. A linear asymptotic stability analysis, that concerns the lower-branch structure of the neutral curve, is presented in the limit of large Reynolds number. It is shown that the lower-branch mode is destabilised and stabilised for shear-thinning and shear-thickening fluids, respectively. Favourable agreement is obtained between these asymptotic predictions and numerical results obtained from an equivalent Orr-Sommerfeld type analysis. Our results indicate that an increase in shear-thinning has the effect of significantly reducing the value of the critical Reynolds number, this suggests that the onset of instability will be significantly advanced in this case. This postulation, that shear-thinning destabilises the boundary layer flow, is further supported by our calculations regarding the development of the streamwise eigenfunctions and the relative magnitude of the temporal growth rates.

Location and extent of Tertiary structures in Cook Inlet Basin, Alaska, and mantle dynamics that focus deformation and subsidence

USGS Publications Warehouse

Haeussler, Peter J.; Saltus, Richard W.

2011-01-01

Subduction of the buoyant Yakutat microplate likely caused deformation to be focused preferentially in upper Cook Inlet. The upper Cook Inlet region has both the highest degree of shortening and the deepest part of the Neogene basin. This forearc region has a long-wavelength magnetic high, a large isostatic gravity low, high conductivity in the lower mantle, low p-wave velocity (Vp), and a high p-wave to shear-wave velocity ratio (Vp/Vs). These data suggest that fluids in the mantle wedge caused serpentinization of mafic rocks, which may, at least in part, contribute to the long-wavelength magnetic anomaly. This area lies adjacent to the subducting and buoyant Yakutat microplate slab. We suggest the buoyant Yakutat slab acts much like a squeegee to focus mantle-wedge fluid flow at the margins of the buoyant slab. Such lateral flow is consistent with observed shear-wave splitting directions. The additional fluid in the adjacent mantle wedge reduces the wedge viscosity and allows greater corner flow. This results in focused subsidence, deformation, and gravity anomalies in the forearc region.

Microbial alignment in flow changes ocean light climate.

PubMed

Marcos; Seymour, Justin R; Luhar, Mitul; Durham, William M; Mitchell, James G; Macke, Andreas; Stocker, Roman

2011-03-08

The growth of microbial cultures in the laboratory often is assessed informally with a quick flick of the wrist: dense suspensions of microorganisms produce translucent "swirls" when agitated. Here, we rationalize the mechanism behind this phenomenon and show that the same process may affect the propagation of light through the upper ocean. Analogous to the shaken test tubes, the ocean can be characterized by intense fluid motion and abundant microorganisms. We demonstrate that the swirl patterns arise when elongated microorganisms align preferentially in the direction of fluid flow and alter light scattering. Using a combination of experiments and mathematical modeling, we find that this phenomenon can be recurrent under typical marine conditions. Moderate shear rates (0.1 s(-1)) can increase optical backscattering of natural microbial assemblages by more than 20%, and even small shear rates (0.001 s(-1)) can increase backscattering from blooms of large phytoplankton by more than 30%. These results imply that fluid flow, currently neglected in models of marine optics, may exert an important control on light propagation, influencing rates of global carbon fixation and how we estimate these rates via remote sensing.

Exact-solution for cone-plate viscometry

NASA Astrophysics Data System (ADS)

Giacomin, A. J.; Gilbert, P. H.

2017-11-01

The viscosity of a Newtonian fluid is often measured by confining the fluid to the gap between a rotating cone that is perpendicular to a fixed disk. We call this experiment cone-plate viscometry. When the cone angle approaches π/2 , the viscometer gap is called narrow. The shear stress in the fluid, throughout a narrow gap, hardly departs from the shear stress exerted on the plate, and we thus call cone-plate flow nearly homogeneous. In this paper, we derive an exact solution for this slight heterogeneity, and from this, we derive the correction factors for the shear rate on the cone and plate, for the torque, and thus, for the measured Newtonian viscosity. These factors thus allow the cone-plate viscometer to be used more accurately, and with cone-angles well below π/2 . We find cone-plate flow field heterogeneity to be far slighter than previously thought. We next use our exact solution for the velocity to arrive at the exact solution for the temperature rise, due to viscous dissipation, in cone-plate flow subject to isothermal boundaries. Since Newtonian viscosity is a strong function of temperature, we expect our new exact solution for the temperature rise be useful to those measuring Newtonian viscosity, and especially so, to those using wide gaps. We include two worked examples to teach practitioners how to use our main results.

Theory of ion Bernstein wave induced shear suppression of turbulence

NASA Astrophysics Data System (ADS)

Craddock, G. G.; Diamond, P. H.; Ono, M.; Biglari, H.

1994-06-01

The theory of radio frequency induced ion Bernstein wave- (IBW) driven shear flow in the edge is examined, with the goal of application of shear suppression of fluctuations. This work is motivated by the observed confinement improvement on IBW heated tokamaks [Phys. Fluids B 5, 241 (1993)], and by previous low-frequency work on RF-driven shear flows [Phys. Rev. Lett. 67, 1535 (1991)]. It is found that the poloidal shear flow is driven electrostatically by both Reynolds stress and a direct ion momentum source, analogous to the concepts of helicity injection and electron momentum input in current drive, respectively. Flow drive by the former does not necessarily require momentum input to the plasma to induce a shear flow. For IBW, the direct ion momentum can be represented by direct electron momentum input, and a charge separation induced stress that imparts little momentum to the plasma. The derived Er profile due to IBW predominantly points inward, with little possibility of direction change, unlike low-frequency Alfvénic RF drive. The profile scale is set by the edge density gradient and electron dissipation. Due to the electrostatic nature of ion Bernstein waves, the poloidal flow contribution dominates in Er. Finally, the necessary edge power absorbed for shear suppression on Princeton Beta Experiment-Modified (PBX-M) [9th Topical Conference on Radio Frequency Power in Plasmas, Charleston, SC, 1991 (American Institute of Physics, New York, 1991), p. 129] is estimated to be 100 kW distributed over 5 cm.

Fluid displacement during droplet formation at microfluidic flow-focusing junctions.

PubMed

Huang, Haishui; He, Xiaoming

2015-11-07

Microdroplets and microcapsules have been widely produced using microfluidic flow-focusing junctions for biomedical and chemical applications. However, the multiphase microfluidic flow at the flow-focusing junction has not been well investigated. In this study, the displacement of two (core and shell) aqueous fluids that disperse into droplets altogether in a carrier oil emulsion was investigated both numerically and experimentally. It was found that extensive displacement of the two aqueous fluids within the droplet during its formation could occur as a result of the shear effect of the carrier fluid and the capillary effect of interfacial tension. We further identified that the two mechanisms of fluid displacement can be evaluated by two dimensionless parameters. The quantitative relationship between the degree of fluid displacement and these two dimensionless parameters was determined experimentally. Finally, we demonstrated that the degree of fluid displacement could be controlled to generate hydrogel microparticles of different morphologies using planar or nonplanar flow-focusing junctions. These findings should provide useful guidance to the microfluidic production of microscale droplets or capsules for various biomedical and chemical applications.

Turbulent motion of mass flows. Mathematical modeling

NASA Astrophysics Data System (ADS)

Eglit, Margarita; Yakubenko, Alexander; Yakubenko, Tatiana

2016-04-01

New mathematical models for unsteady turbulent mass flows, e.g., dense snow avalanches and landslides, are presented. Such models are important since most of large scale flows are turbulent. In addition to turbulence, the two other important points are taken into account: the entrainment of the underlying material by the flow and the nonlinear rheology of moving material. The majority of existing models are based on the depth-averaged equations and the turbulent character of the flow is accounted by inclusion of drag proportional to the velocity squared. In this paper full (not depth-averaged) equations are used. It is assumed that basal entrainment takes place if the bed friction equals the shear strength of the underlying layer (Issler D, M. Pastor Peréz. 2011). The turbulent characteristics of the flow are calculated using a three-parameter differential model (Lushchik et al., 1978). The rheological properties of moving material are modeled by one of the three types of equations: 1) Newtonian fluid with high viscosity, 2) power-law fluid and 3) Bingham fluid. Unsteady turbulent flows down long homogeneous slope are considered. The flow dynamical parameters and entrainment rate behavior in time as well as their dependence on properties of moving and underlying materials are studied numerically. REFERENCES M.E. Eglit and A.E. Yakubenko, 2014. Numerical modeling of slope flows entraining bottom material. Cold Reg. Sci. Technol., 108, 139-148 Margarita E. Eglit and Alexander E. Yakubenko, 2016. The effect of bed material entrainment and non-Newtonian rheology on dynamics of turbulent slope flows. Fluid Dynamics, 51(3) Issler D, M. Pastor Peréz. 2011. Interplay of entrainment and rheology in snow avalanches; a numerical study. Annals of Glaciology, 52(58), 143-147 Lushchik, V.G., Paveliev, A.A. , and Yakubenko, A.E., 1978. Three-parameter model of shear turbulence. Fluid Dynamics, 13, (3), 350-362

Numerical investigation of laminar forced convection in Newtonian and non-Newtonian flows in eccentric annuli

NASA Astrophysics Data System (ADS)

Fang, Pingping

1998-12-01

An extended numerical investigation of fully developed, forced convective laminar flows with heat transfer in eccentric annuli has been carried out. Both Newtonian and non-Newtonian (power-law or Ostwald-de Waele) fluids are studied, representing typical applications in petrochemical, bio-chemical, personal care products, polymer/plastic extrusion and food industries. For the heat transfer problem, with an insulated outer surface, two types of thermal boundary conditions have been considered: Constant wall temperature (T), and uniform axial heat flux with constant peripheral temperature (H1) on the inner surface of the annulus. The governing differential equations for momentum and energy conservation are solved by finite-difference methods. Velocity and temperature distributions in the flow cross section, the wall shear-stress distribution, and isothermal f Re, Nu i,T and Nu i,H1 values for different eccentric annuli (0/leɛ/*/le0.6,/ 0.2/le r/sp/*/le0.8) are presented. In Newtonian flows, the eccentricity is found to have a very strong influence on the flow and temperature fields. In an annulus with relatively large inner cylinder eccentricity, the flow tends to stagnate in the narrow section and has higher peak velocities in the wide section of the annulus. There is considerable flow maldistribution in the azimuthal direction, which in turn produces greater nonuniformity in the temperature field and a consequent degradation in the average heat transfer. Also, the H1 wall condition sustains higher heat transfer coefficients relative to the T boundary condition on the inner surface. For viscous, power-law type non-Newtonian flows, both shear thinning (n<1) and shear thickening (n>1) fluids are considered. Here, the non-linear shear behavior of the fluid is found to further aggravate the flow and temperature maldistribution, and once again the eccentricity is seen to exhibit a very strong influence on the friction and heat transfer behavior. Finally, the hydrodynamic characteristics of fully developed axial laminar flow of Newtonian fluids in eccentric annuli with a rotating inner cylinder are investigated. These are of significant importance to the design and operation of oil and gas drilling wells. Using finite-difference method to solve the governing flow equations in bipolar coordinates, computational results for a wide range of annulus geometry (0/le r/sp/*/le1,/ 0/le/varepsilon/sp/*/le0.8), and rotational Reynolds number (0/le Rer/le150) are presented, where the rotational speeds are restricted to the sub-critical Taylor number regime. The results delineate the effects of annuli r/sp/* and ɛsp/*, and inner cylinder rotation speed on the flow structure and frictional losses.

Development and application of a volume penalization immersed boundary method for the computation of blood flow and shear stresses in cerebral vessels and aneurysms.

PubMed

Mikhal, Julia; Geurts, Bernard J

2013-12-01

A volume-penalizing immersed boundary method is presented for the simulation of laminar incompressible flow inside geometrically complex blood vessels in the human brain. We concentrate on cerebral aneurysms and compute flow in curved brain vessels with and without spherical aneurysm cavities attached. We approximate blood as an incompressible Newtonian fluid and simulate the flow with the use of a skew-symmetric finite-volume discretization and explicit time-stepping. A key element of the immersed boundary method is the so-called masking function. This is a binary function with which we identify at any location in the domain whether it is 'solid' or 'fluid', allowing to represent objects immersed in a Cartesian grid. We compare three definitions of the masking function for geometries that are non-aligned with the grid. In each case a 'staircase' representation is used in which a grid cell is either 'solid' or 'fluid'. Reliable findings are obtained with our immersed boundary method, even at fairly coarse meshes with about 16 grid cells across a velocity profile. The validation of the immersed boundary method is provided on the basis of classical Poiseuille flow in a cylindrical pipe. We obtain first order convergence for the velocity and the shear stress, reflecting the fact that in our approach the solid-fluid interface is localized with an accuracy on the order of a grid cell. Simulations for curved vessels and aneurysms are done for different flow regimes, characterized by different values of the Reynolds number (Re). The validation is performed for laminar flow at Re = 250, while the flow in more complex geometries is studied at Re = 100 and Re = 250, as suggested by physiological conditions pertaining to flow of blood in the circle of Willis.

Study of blood flow in several benchmark micro-channels using a two-fluid approach.

PubMed

Wu, Wei-Tao; Yang, Fang; Antaki, James F; Aubry, Nadine; Massoudi, Mehrdad

2015-10-01

It is known that in a vessel whose characteristic dimension (e.g., its diameter) is in the range of 20 to 500 microns, blood behaves as a non-Newtonian fluid, exhibiting complex phenomena, such as shear-thinning, stress relaxation, and also multi-component behaviors, such as the Fahraeus effect, plasma-skimming, etc. For describing these non-Newtonian and multi-component characteristics of blood, using the framework of mixture theory, a two-fluid model is applied, where the plasma is treated as a Newtonian fluid and the red blood cells (RBCs) are treated as shear-thinning fluid. A computational fluid dynamic (CFD) simulation incorporating the constitutive model was implemented using OpenFOAM® in which benchmark problems including a sudden expansion and various driven slots and crevices were studied numerically. The numerical results exhibited good agreement with the experimental observations with respect to both the velocity field and the volume fraction distribution of RBCs.

Turbulence and mixing from optimal perturbations to a stratified shear layer

NASA Astrophysics Data System (ADS)

Kaminski, Alexis; Caulfield, C. P.; Taylor, John

2014-11-01

The stability and mixing of stratified shear layers is a canonical problem in fluid dynamics with relevance to flows in the ocean and atmosphere. The Miles-Howard theorem states that a necessary condition for normal-mode instability in parallel, inviscid, steady stratified shear flows is that the gradient Richardson number, Rig is less than 1/4 somewhere in the flow. However, substantial transient growth of non-normal modes may be possible at finite times even when Rig > 1 / 4 everywhere in the flow. We have calculated the ``optimal perturbations'' associated with maximum perturbation energy gain for a stably-stratified shear layer. These optimal perturbations are then used to initialize direct numerical simulations. For small but finite perturbation amplitudes, the optimal perturbations grow at the predicted linear rate initially, but then experience sufficient transient growth to become nonlinear and susceptible to secondary instabilities, which then break down into turbulence. Remarkably, this occurs even in flows for which Rig > 1 / 4 everywhere. We will describe the nonlinear evolution of the optimal perturbations and characterize the resulting turbulence and mixing.

Mechanosensation and the Primary Cilium

NASA Astrophysics Data System (ADS)

Glaser, Joseph; Resnick, Andrew

2010-10-01

The primary cilium has come under increased scrutiny as a site for mechano- and chemosensation by cells. We have undertaken a program of study using mouse renal cell lines from the cortical collecting duct to quantify how mechanical forces arising from fluid shear are transduced into cellular responses. Fluid flow through a model nephron has been analyzed to determine the in vivo forces. A novel tissue culture flow chamber permitting accurate reproduction of physiologically relevant conditions has been calibrated. We have determined that in vivo conditions can be accurately modeled in our flow chamber.

Mobility of power-law and Carreau fluids through fibrous media.

PubMed

Shahsavari, Setareh; McKinley, Gareth H

2015-12-01

The flow of generalized Newtonian fluids with a rate-dependent viscosity through fibrous media is studied, with a focus on developing relationships for evaluating the effective fluid mobility. Three methods are used here: (i) a numerical solution of the Cauchy momentum equation with the Carreau or power-law constitutive equations for pressure-driven flow in a fiber bed consisting of a periodic array of cylindrical fibers, (ii) an analytical solution for a unit cell model representing the flow characteristics of a periodic fibrous medium, and (iii) a scaling analysis of characteristic bulk parameters such as the effective shear rate, the effective viscosity, geometrical parameters of the system, and the fluid rheology. Our scaling analysis yields simple expressions for evaluating the transverse mobility functions for each model, which can be used for a wide range of medium porosity and fluid rheological parameters. While the dimensionless mobility is, in general, a function of the Carreau number and the medium porosity, our results show that for porosities less than ɛ≃0.65, the dimensionless mobility becomes independent of the Carreau number and the mobility function exhibits power-law characteristics as a result of the high shear rates at the pore scale. We derive a suitable criterion for determining the flow regime and the transition from a constant viscosity Newtonian response to a power-law regime in terms of a new Carreau number rescaled with a dimensionless function which incorporates the medium porosity and the arrangement of fibers.

Cyclical shear fracture and viscous flow during transitional ductile-brittle deformation in the Saddlebag Lake Shear Zone, California

NASA Astrophysics Data System (ADS)

Compton, Katharine E.; Kirkpatrick, James D.; Holk, Gregory J.

2017-06-01

Exhumed shear zones often contain folded and/or dynamically recrystallized structures, such as veins and pseudotachylytes, which record broadly contemporaneous brittle and ductile deformation. Here, we investigate veins within the Saddlebag Lake Shear Zone, central Sierra Nevada, California, to constrain the conditions and processes that caused fractures to form during ductile deformation. The shear zone mylonites contain compositional banding at centimeter- to meter- scales, and a ubiquitous, grain-scale, continuous- to spaced-foliation defined by aligned muscovite and chlorite grains. Veins of multiple compositions formed in two predominant sets: sub-parallel to the foliation and at high angle to the foliation. Some foliation sub-parallel veins show apparent shear offset consistent with the overall kinematics of the shear zone. These veins are folded with the foliation and are commonly boudinaged, showing they were rigid inclusions after formation. Quartz microstructures and fluid inclusion thermobarometry measurements indicate the veins formed by fracture at temperatures between 400-600 °C. Quartz, feldspar and tourmaline δ18O values (+ 2.5 to + 16.5) suggest extended fluid-rock interaction that involved magmatic, metamorphic, and meteoric-hydrothermal fluids. The orientation and spatial distribution of the veins shows that shear fractures formed along mechanically weak foliation planes. We infer fracture was promoted by perturbations to the strain rate and/or pore pressure during frictional-viscous deformation in a low effective stress environment. Evidence for repeated fracture and subsequent flow suggest both the stress and pore pressure varied, and that the tendency to fracture was controlled by the rates of pore pressure recovery, facilitated by fracture cementation. The tectonic setting and inferred phenomenological behavior were similar to intra-continental transform faults that host triggered tectonic tremor, suggesting the mechanisms that caused brittle fracture during viscous deformation may be important for comparable active systems.

Optimized Design of Spacer in Electrodialyzer Using CFD Simulation Method

NASA Astrophysics Data System (ADS)

Jia, Yuxiang; Yan, Chunsheng; Chen, Lijun; Hu, Yangdong

2018-06-01

In this study, the effects of length-width ratio and diversion trench of the spacer on the fluid flow behavior in an electrodialyzer have been investigated through CFD simulation method. The relevant information, including the pressure drop, velocity vector distribution and shear stress distribution, demonstrates the importance of optimized design of the spacer in an electrodialysis process. The results show width of the diversion trench has a great effect on the fluid flow compared with length. Increase of the diversion trench width could strength the fluid flow, but also increase the pressure drop. Secondly, the dead zone of the fluid flow decreases with increase of length-width ratio of the spacer, but the pressure drop increases with the increase of length-width ratio of the spacer. So the appropriate length-width ratio of the space should be moderate.

Experimental investigation of certain internal condensing and boiling flows: Their sensitivity to pressure fluctuations and heat transfer enhancements

NASA Astrophysics Data System (ADS)

Kivisalu, Michael Toomas

Space-based (satellite, scientific probe, space station, etc.) and millimeter -- to -- micro-scale (such as are used in high power electronics cooling, weapons cooling in aircraft, etc.) condensers and boilers are shear/pressure driven. They are of increasing interest to system engineers for thermal management because flow boilers and flow condensers offer both high fluid flow-rate-specific heat transfer capacity and very low thermal resistance between the fluid and the heat exchange surface, so large amounts of heat may be removed using reasonably-sized devices without the need for excessive temperature differences. However, flow stability issues and degredation of performance of shear/pressure driven condensers and boilers due to non-desireable flow morphology over large portions of their lengths have mostly prevented their use in these applications. This research is part of an ongoing investigation seeking to close the gap between science and engineering by analyzing two key innovations which could help address these problems. First, it is recommended that the condenser and boiler be operated in an innovative flow configuration which provides a non-participating core vapor stream to stabilize the annular flow regime throughout the device length, accomplished in an energy-efficient manner by means of ducted vapor re-circulation. This is demonstrated experimentally.. Second, suitable pulsations applied to the vapor entering the condenser or boiler (from the re-circulating vapor stream) greatly reduce the thermal resistance of the already effective annular flow regime. For experiments reported here, application of pulsations increased time-averaged heat-flux up to 900 % at a location within the flow condenser and up to 200 % at a location within the flow boiler, measured at the heat-exchange surface. Traditional fully condensing flows, reported here for comparison purposes, show similar heat-flux enhancements due to imposed pulsations over a range of frequencies. Shear/pressure driven condensing and boiling flow experiments are carried out in horizontal mm-scale channels with heat exchange through the bottom surface. The sides and top of the flow channel are insulated. The fluid is FC-72 from 3M Corporation.

Fluid mechanics of human fetal right ventricles from image-based computational fluid dynamics using 4D clinical ultrasound scans.

PubMed

Wiputra, Hadi; Lai, Chang Quan; Lim, Guat Ling; Heng, Joel Jia Wei; Guo, Lan; Soomar, Sanah Merchant; Leo, Hwa Liang; Biwas, Arijit; Mattar, Citra Nurfarah Zaini; Yap, Choon Hwai

2016-12-01

There are 0.6-1.9% of US children who were born with congenital heart malformations. Clinical and animal studies suggest that abnormal blood flow forces might play a role in causing these malformation, highlighting the importance of understanding the fetal cardiovascular fluid mechanics. We performed computational fluid dynamics simulations of the right ventricles, based on four-dimensional ultrasound scans of three 20-wk-old normal human fetuses, to characterize their flow and energy dynamics. Peak intraventricular pressure gradients were found to be 0.2-0.9 mmHg during systole, and 0.1-0.2 mmHg during diastole. Diastolic wall shear stresses were found to be around 1 Pa, which could elevate to 2-4 Pa during systole in the outflow tract. Fetal right ventricles have complex flow patterns featuring two interacting diastolic vortex rings, formed during diastolic E wave and A wave. These rings persisted through the end of systole and elevated wall shear stresses in their proximity. They were observed to conserve ∼25.0% of peak diastolic kinetic energy to be carried over into the subsequent systole. However, this carried-over kinetic energy did not significantly alter the work done by the heart for ejection. Thus, while diastolic vortexes played a significant role in determining spatial patterns and magnitudes of diastolic wall shear stresses, they did not have significant influence on systolic ejection. Our results can serve as a baseline for future comparison with diseased hearts. Copyright © 2016 the American Physiological Society.

Simulation of forced convection in non-Newtonian fluid through sandstones

NASA Astrophysics Data System (ADS)

Gokhale, M. Y.; Fernandes, Ignatius

2017-11-01

Numerical simulation is carried out to study forced convection in non-Newtonian fluids flowing through sandstones. Simulation is carried out using lattice Boltzmann method (LBM) for both shear-thinning and shear-thickening, by varying the power law index from 0.5 to 1.5 in Carreau-Yasuda model. Parameters involved in LBM and Carreau model are identified to achieve numerical convergence. Permeability and porosity are varied in the range of 10-10-10-6 and 0.1-0.7, respectively, to match actual geometrical properties of sandstone. Numerical technology is validated by establishing Darcy's law by plotting the graph between velocity and pressure gradient. Consequently, investigation is carried out to study the influence of material properties of porous media on flow properties such as velocity profiles, temperature profiles, and Nusselt number.

Two-dimensional interaction of a shear flow with a free surface in a stratified fluid and its solitary-wave solutions via mathematical methods

NASA Astrophysics Data System (ADS)

Seadawy, Aly R.

2017-12-01

In this study, we presented the problem formulations of models for internal solitary waves in a stratified shear flow with a free surface. The nonlinear higher order of extended KdV equations for the free surface displacement is generated. We derived the coefficients of the nonlinear higher-order extended KdV equation in terms of integrals of the modal function for the linear long-wave theory. The wave amplitude potential and the fluid pressure of the extended KdV equation in the form of solitary-wave solutions are deduced. We discussed and analyzed the stability of the obtained solutions and the movement role of the waves by making graphs of the exact solutions.

A thermodynamically consistent model for granular-fluid mixtures considering pore pressure evolution and hypoplastic behavior

NASA Astrophysics Data System (ADS)

Hess, Julian; Wang, Yongqi

2016-11-01

A new mixture model for granular-fluid flows, which is thermodynamically consistent with the entropy principle, is presented. The extra pore pressure described by a pressure diffusion equation and the hypoplastic material behavior obeying a transport equation are taken into account. The model is applied to granular-fluid flows, using a closing assumption in conjunction with the dynamic fluid pressure to describe the pressure-like residual unknowns, hereby overcoming previous uncertainties in the modeling process. Besides the thermodynamically consistent modeling, numerical simulations are carried out and demonstrate physically reasonable results, including simple shear flow in order to investigate the vertical distribution of the physical quantities, and a mixture flow down an inclined plane by means of the depth-integrated model. Results presented give insight in the ability of the deduced model to capture the key characteristics of granular-fluid flows. We acknowledge the support of the Deutsche Forschungsgemeinschaft (DFG) for this work within the Project Number WA 2610/3-1.

Interaction of aluminum oxide nanoparticles with flow of polyvinyl alcohol solutions base nanofluids over a wedge

NASA Astrophysics Data System (ADS)

Hassan, Mohsan; Faisal, Abrar; Bhatti, Muhammad Mubashir

2018-02-01

Polyvinyl alcohol (PVA) is an important industrial chemical, which is used in numerous chemical engineering applications. It is important to study and predict the flow behavior of PVA solutions and the role of nanoparticles in heat transfer applications to be used in chemical processes on industrial scale. Therefore, the present study deals with the PVA solution-based non-Newtonian Al2O3-nanofluid flow along with heat transfer over wedge. The power-law model is used for this non-Newtonian nanofluid which exhibited shear-thinning behavior. The influences of PVA and nanoparticles concentrations on the characteristics of velocity and temperature profiles are examined graphically. The impacts of these parameters on wall shear stress and convective heat transfer coefficient are also studied through tabular form. During the numerical computations, the impacts of these parameters on flow index and consistency index along with other physical properties of nanofluid are also considered. In this study, we found an improvement in heat transfer and temperature profile of fluid by distribution of Al2O3 nanoparticles. It is also noticed that resistance between adjacent layers of moving fluid is enhanced due to these nanoparticles which leads to decline in velocity profile and increases in shear stress at wall.

A fiber matrix model for fluid flow and streaming potentials in the canaliculi of an osteon

NASA Technical Reports Server (NTRS)

Zeng, Y.; Cowin, S. C.; Weinbaum, S.

1994-01-01

A theoretical model is developed to predict the fluid shear stress and streaming potential at the surface of osteocytic processes in the lacunar-canalicular porosity of an osteon when the osteon is subject to mechanical loads that are parallel or perpendicular to its axis. The theory developed in Weinbaum et al. (31) for the flow through a proteoglycan matrix in a canaliculus is employed in a poroelastic model for the osteon. Our formulation is a generalization of that of Petrov et al. (17). Our model predicts that, in order to satisfy the measured frequency dependence of the phase and magnitude of the SGP in macroscopic bone samples, the fiber spacing in the fluid annulus must lie in the narrow range 6-7 nm typical of the spacing of GAG sidechains along a protein monomer. The model predictions for the local SGP profiles in the osteon agree with the experimental observations of Starkebaum et al. (24). The theory predicts that the pore pressure relaxation time, tau d, for a 150-300 microns diameter osteon with the foregoing matrix structure is approximately 0.03-0.13 sec, and that the amplitude of the mean fluid shear stress on the membrane of the osteocytic process at the mean areal radius of the osteon has a maximum at 28 Hz if tau d = 0.06 sec. This maximum, which is independent of the magnitude of the loading, could be important in vivo since the recent experiments of Turner et al. (28) and McLeod et al. (15) have a peak in the strain frequency spectrum between 20 and 30 Hz that also appears to be independent of the type (magnitude) of loading. Numerical predictions for the amplitude of the average fluid shear stress on the osteocytic membrane at the mean areal radius of the osteon show that the fluid shear stress associated with the low amplitude 20-30 Hz spectral strain component is at least as large as the average fluid shear stress associated with the high amplitude 1 Hz stride component, although the latter loading is an order of magnitude larger, and has a magnitude that lies within the middle of the range, 6-30 dynes/cm2, where fluid shear stresses in tissue culture studies with osteoblast monolayers have elicited an intracellular Ca++ response (31). The implications of these results for intracellular electrical communication are discussed.

The physics of debris flows

NASA Astrophysics Data System (ADS)

Iverson, Richard M.

1997-08-01

Recent advances in theory and experimentation motivate a thorough reassessment of the physics of debris flows. Analyses of flows of dry, granular solids and solid-fluid mixtures provide a foundation for a comprehensive debris flow theory, and experiments provide data that reveal the strengths and limitations of theoretical models. Both debris flow materials and dry granular materials can sustain shear stresses while remaining static; both can deform in a slow, tranquil mode characterized by enduring, frictional grain contacts; and both can flow in a more rapid, agitated mode characterized by brief, inelastic grain collisions. In debris flows, however, pore fluid that is highly viscous and nearly incompressible, composed of water with suspended silt and clay, can strongly mediate intergranular friction and collisions. Grain friction, grain collisions, and viscous fluid flow may transfer significant momentum simultaneously. Both the vibrational kinetic energy of solid grains (measured by a quantity termed the granular temperature) and the pressure of the intervening pore fluid facilitate motion of grains past one another, thereby enhancing debris flow mobility. Granular temperature arises from conversion of flow translational energy to grain vibrational energy, a process that depends on shear rates, grain properties, boundary conditions, and the ambient fluid viscosity and pressure. Pore fluid pressures that exceed static equilibrium pressures result from local or global debris contraction. Like larger, natural debris flows, experimental debris flows of ˜10 m³ of poorly sorted, water-saturated sediment invariably move as an unsteady surge or series of surges. Measurements at the base of experimental flows show that coarse-grained surge fronts have little or no pore fluid pressure. In contrast, finer-grained, thoroughly saturated debris behind surge fronts is nearly liquefied by high pore pressure, which persists owing to the great compressibility and moderate permeability of the debris. Realistic models of debris flows therefore require equations that simulate inertial motion of surges in which high-resistance fronts dominated by solid forces impede the motion of low-resistance tails more strongly influenced by fluid forces. Furthermore, because debris flows characteristically originate as nearly rigid sediment masses, transform at least partly to liquefied flows, and then transform again to nearly rigid deposits, acceptable models must simulate an evolution of material behavior without invoking preternatural changes in material properties. A simple model that satisfies most of these criteria uses depth-averaged equations of motion patterned after those of the Savage-Hutter theory for gravity-driven flow of dry granular masses but generalized to include the effects of viscous pore fluid with varying pressure. These equations can describe a spectrum of debris flow behaviors intermediate between those of wet rock avalanches and sediment-laden water floods. With appropriate pore pressure distributions the equations yield numerical solutions that successfully predict unsteady, nonuniform motion of experimental debris flows.

The physics of debris flows

USGS Publications Warehouse

Iverson, R.M.

1997-01-01

Recent advances in theory and experimentation motivate a thorough reassessment of the physics of debris flows. Analyses of flows of dry, granular solids and solid-fluid mixtures provide a foundation for a comprehensive debris flow theory, and experiments provide data that reveal the strengths and limitations of theoretical models. Both debris flow materials and dry granular materials can sustain shear stresses while remaining static; both can deform in a slow, tranquil mode characterized by enduring, frictional grain contacts; and both can flow in a more rapid, agitated mode characterized by brief, inelastic grain collisions. In debris flows, however, pore fluid that is highly viscous and nearly incompressible, composed of water with suspended silt and clay, can strongly mediate intergranular friction and collisions. Grain friction, grain collisions, and viscous fluid flow may transfer significant momentum simultaneously. Both the vibrational kinetic energy of solid grains (measured by a quantity termed the granular temperature) and the pressure of the intervening pore fluid facilitate motion of grains past one another, thereby enhancing debris flow mobility. Granular temperature arises from conversion of flow translational energy to grain vibrational energy, a process that depends on shear rates, grain properties, boundary conditions, and the ambient fluid viscosity and pressure. Pore fluid pressures that exceed static equilibrium pressures result from local or global debris contraction. Like larger, natural debris flows, experimental debris flows of ???10 m3 of poorly sorted, water-saturated sediment invariably move as an unsteady surge or series of surges. Measurements at the base of experimental flows show that coarse-grained surge fronts have little or no pore fluid pressure. In contrast, finer-grained, thoroughly saturated debris behind surge fronts is nearly liquefied by high pore pressure, which persists owing to the great compressibility and moderate permeability of the debris. Realistic models of debris flows therefore require equations that simulate inertial motion of surges in which high-resistance fronts dominated by solid forces impede the motion of low-resistance tails more strongly influenced by fluid forces. Furthermore, because debris flows characteristically originate as nearly rigid sediment masses, transform at least partly to liquefied flows, and then transform again to nearly rigid deposits, acceptable models must simulate an evolution of material behavior without invoking preternatural changes in material properties. A simple model that satisfies most of these criteria uses depth-averaged equations of motion patterned after those of the Savage-Hutter theory for gravity-driven flow of dry granular masses but generalized to include the effects of viscous pore fluid with varying pressure. These equations can describe a spectrum of debris flow behaviors intermediate between those of wet rock avalanches and sediment-laden water floods. With appropriate pore pressure distributions the equations yield numerical solutions that successfully predict unsteady, nonuniform motion of experimental debris flows.

Nonlinear hydrodynamic stability and transition; Proceedings of the IUTAM Symposium, Nice, France, Sept. 3-7, 1990

NASA Astrophysics Data System (ADS)

Theoretical and experimental research on nonlinear hydrodynamic stability and transition is presented. Bifurcations, amplitude equations, pattern in experiments, and shear flows are considered. Particular attention is given to bifurcations of plane viscous fluid flow and transition to turbulence, chaotic traveling wave covection, chaotic behavior of parametrically excited surface waves in square geometry, amplitude analysis of the Swift-Hohenberg equation, traveling wave convection in finite containers, focus instability in axisymmetric Rayleigh-Benard convection, scaling and pattern formation in flowing sand, dynamical behavior of instabilities in spherical gap flows, and nonlinear short-wavelength Taylor vortices. Also discussed are stability of a flow past a two-dimensional grid, inertia wave breakdown in a precessing fluid, flow-induced instabilities in directional solidification, structure and dynamical properties of convection in binary fluid mixtures, and instability competition for convecting superfluid mixtures.

Imaging the microscopic structure of shear thinning and thickening colloidal suspensions.

PubMed

Cheng, Xiang; McCoy, Jonathan H; Israelachvili, Jacob N; Cohen, Itai

2011-09-02

The viscosity of colloidal suspensions varies with shear rate, an important effect encountered in many natural and industrial processes. Although this non-Newtonian behavior is believed to arise from the arrangement of suspended particles and their mutual interactions, microscopic particle dynamics are difficult to measure. By combining fast confocal microscopy with simultaneous force measurements, we systematically investigate a suspension's structure as it transitions through regimes of different flow signatures. Our measurements of the microscopic single-particle dynamics show that shear thinning results from the decreased relative contribution of entropic forces and that shear thickening arises from particle clustering induced by hydrodynamic lubrication forces. This combination of techniques illustrates an approach that complements current methods for determining the microscopic origins of non-Newtonian flow behavior in complex fluids.

Asymmetric Reconnection With A Shear Flow and Applications to X-line Motion at the Polar Cusps

NASA Astrophysics Data System (ADS)

Doss, C.; Komar, C. M.; Beidler, M.; Cassak, P.; Wilder, F. D.; Eriksson, S.

2014-12-01

Magnetic reconnection at the polar cusps of the magnetosphere is marked by strong asymmetries in plasma density and magnetic field strength in addition to a potentially strong bulk flow shear parallel to the reconnecting magnetic field caused by the solar wind. Much has been learned about the effect of either asymmetries or shear flow on reconnection, but only a handful of studies have addressed systems with both. We perform a careful theoretical, numerical, and observational study of such systems. It is known that an asymmetry in magnetic field offsets the X-line from the center of the diffusion region in the inflow direction toward the weaker magnetic field. A key finding is that this alters the flow profile seen at the X-line relative to expectations from symmetric reconnection results. This causes the X-line to drift in the outflow direction due to the shear flow. We calculate a prediction for the X-line drift speed for arbitrary asymmetric magnetic field strengths and show the result is consistent with two-fluid numerical simulations. These predictions are also shown to be consistent with recent observations of a tailward moving X-line in Cluster observations of reconnection at the polar cusp. The reconnection rate with a shear flow is observed to drop as in symmetric reconnection, and the behavior of the reconnection qualitatively changes when the shear flow speed exceeds the hybrid Alfven speed of the outflow known from asymmetric reconnection theory.

Impact of induced magnetic field on synovial fluid with peristaltic flow in an asymmetric channel

NASA Astrophysics Data System (ADS)

Afsar Khan, Ambreen; Farooq, Arfa; Vafai, Kambiz

2018-01-01

In this paper, we have worked for the impact of induced magnetic field on peristaltic motion of a non-Newtonian, incompressible, synovial fluid in an asymmetric channel. We have solved the problem for two models, Model-1 which behaves as shear thinning fluid and Model-2 which behaves as shear thickening fluid. The problem is solved by using modified Adomian Decomposition method. It has seen that two models behave quite opposite to each other for some parameters. The impact of various parameters on u, dp/dx, Δp and induced magnetic field bx have been studied graphically. The significant findings of this study is that the size of the trapped bolus and the pressure gradient increases by increasing M for both models.

Microfluidic rheology of active particle suspensions: Kinetic theory

NASA Astrophysics Data System (ADS)

Alonso-Matilla, Roberto; Ezhilan, Barath; Saintillan, David

2016-11-01

We analyze the effective rheology of a dilute suspension of self-propelled slender particles between two infinite parallel plates in a pressure-driven flow. We use a continuum kinetic model to study the dynamics and transport of particles, where hydrodynamic interactions induced by the swimmers are taken into account. Using finite volume simulations we study how the activity of the swimmer and the external flow modify the rheological properties of the system. Results indicate that at low flow rates, activity decreases the value of the viscosity for pushers and increases its value for pullers. Both effects become weaker with increasing the flow strength due to the alignment of the particles with the flow. In the case of puller particles, shear thinning is observed over the entire range of flow rates. Pusher particles exhibit shear thickening at intermediate flow rates, where passive stresses start dominating over active stresses, reaching a viscosity greater than that of the Newtonian fluid. Finally shear thinning is observed at high flow rates. Both pushers and pullers exhibit a Newtonian plateau at very high flow rates. We demonstrate a good agreement between numerical results and experiments.

Enhanced Amendment Delivery to Subsurface Using Shear Thinning Fluid and Aqueous Foam for Metal, Radionuclide, and NAPL Remediation

NASA Astrophysics Data System (ADS)

Zhong, L.; Szecsody, J.; Li, X.; Oostrom, M.; Truex, M.

2010-12-01

In many contamination sites, removal of contaminants by any active remediation efforts is not practical due to the high cost and technological limitations. Alternatively, in situ remediation is expected to be the most important remediation strategy. Delivery of reactive amendment to the contamination zone is essential for the reactions between the contaminants and remedial amendments to proceed in situ. It is a challenge to effectively deliver remedial amendment to the subsurface contamination source areas in both aquifer and vadose zone. In aquifer, heterogeneity induces fluid bypassing the low-permeability zones, resulting in certain contaminated areas inaccessible to the remedial amendment delivered by water injection, thus inhibiting the success of remedial operations. In vadose zone in situ remediation, conventional solution injection and infiltration for amendment delivery have difficulties to achieve successful lateral spreading and uniform distribution of the reactive media. These approaches also tend to displace highly mobile metal and radionuclide contaminants such as hexavalent chromium [Cr(VI)] and technetium (Tc-99), causing spreading of contaminations. Shear thinning fluid and aqueous foam can be applied to enhance the amendment delivery and improve in situ subsurface remediation efficiency under aquifer and vadose zone conditions, respectively. Column and 2-D flow cell experiments were conducted to demonstrate the enhanced delivery and improved remediation achieved by the application of shear thinning fluid and foam injection at the laboratory scale. Solutions of biopolymer xanthan gum were used as the shear thinning delivering fluids. Surfactant sodium lauryl ether sulfate (STEOL CS-330) was the foaming agent. The shear thinning fluid delivery (STFD) considerably improved the sweeping efficiency over a heterogeneous system and enhanced the non-aqueous liquid phase (NAPL) removal. The delivery of amendment into low-perm zones (LPZs) by STFD also increased the persistence of amendment solution in the LPZs after injection. Immobilization of Tc-99 was improved when a reductant was delivered by foam versus by water-based solution to contaminated vadose zone sediments. Foam delivery remarkably improved the lateral distribution of fluids compared to direct liquid injection. In heterogeneous vadose zone formation, foam injection increased the liquid flow in the high permeable zones into which very limited fluid was distributed during liquid infiltration, demonstrating improved amendment distribution uniformity in the heterogeneous system by foam delivery.

The imperative for controlled mechanical stresses in unraveling cellular mechanisms of mechanotransduction

PubMed Central

Anderson, Eric J; Falls, Thomas D; Sorkin, Adam M; Tate, Melissa L Knothe

2006-01-01

Background In vitro mechanotransduction studies are designed to elucidate cell behavior in response to a well-defined mechanical signal that is imparted to cultured cells, e.g. through fluid flow. Typically, flow rates are calculated based on a parallel plate flow assumption, to achieve a targeted cellular shear stress. This study evaluates the performance of specific flow/perfusion chambers in imparting the targeted stress at the cellular level. Methods To evaluate how well actual flow chambers meet their target stresses (set for 1 and 10 dyn/cm2 for this study) at a cellular level, computational models were developed to calculate flow velocity components and imparted shear stresses for a given pressure gradient. Computational predictions were validated with micro-particle image velocimetry (μPIV) experiments. Results Based on these computational and experimental studies, as few as 66% of cells seeded along the midplane of commonly implemented flow/perfusion chambers are subjected to stresses within ±10% of the target stress. In addition, flow velocities and shear stresses imparted through fluid drag vary as a function of location within each chamber. Hence, not only a limited number of cells are exposed to target stress levels within each chamber, but also neighboring cells may experience different flow regimes. Finally, flow regimes are highly dependent on flow chamber geometry, resulting in significant variation in magnitudes and spatial distributions of stress between chambers. Conclusion The results of this study challenge the basic premise of in vitro mechanotransduction studies, i.e. that a controlled flow regime is applied to impart a defined mechanical stimulus to cells. These results also underscore the fact that data from studies in which different chambers are utilized can not be compared, even if the target stress regimes are comparable. PMID:16672051

Shear-induced criticality near a liquid-solid transition of colloidal suspensions

NASA Astrophysics Data System (ADS)

Miyama, Masamichi J.; Sasa, Shin-Ichi

2011-02-01

We investigate colloidal suspensions under shear flow through numerical experiments. By measuring the time-correlation function of a bond-orientational order parameter, we find a divergent time scale near a transition point from a disordered fluid phase to an ordered fluid phase, where the order is characterized by a nonzero value of the bond-orientational order parameter. We also present a phase diagram in the (ρ,γ˙ex) plane, where ρ is the density of the colloidal particles and γ˙ex is the shear rate of the solvent. The transition line in the phase diagram terminates at the equilibrium transition point, while a critical region near the transition line vanishes continuously as γ˙ex→0.

Inlets, ducts, and nozzles

NASA Technical Reports Server (NTRS)

Abbott, John M.; Anderson, Bernhard H.; Rice, Edward J.

1990-01-01

The internal fluid mechanics research program in inlets, ducts, and nozzles consists of a balanced effort between the development of computational tools (both parabolized Navier-Stokes and full Navier-Stokes) and the conduct of experimental research. The experiments are designed to better understand the fluid flow physics, to develop new or improved flow models, and to provide benchmark quality data sets for validation of the computational methods. The inlet, duct, and nozzle research program is described according to three major classifications of flow phenomena: (1) highly 3-D flow fields; (2) shock-boundary-layer interactions; and (3) shear layer control. Specific examples of current and future elements of the research program are described for each of these phenomenon. In particular, the highly 3-D flow field phenomenon is highlighted by describing the computational and experimental research program in transition ducts having a round-to-rectangular area variation. In the case of shock-boundary-layer interactions, the specific details of research for normal shock-boundary-layer interactions are described. For shear layer control, research in vortex generators and the use of aerodynamic excitation for enhancement of the jet mixing process are described.

Pressure measurements in a rapidly sheared turbulent wall layer

NASA Astrophysics Data System (ADS)

Diwan, Sourabh; Morrison, Jonathan

2014-11-01

The aim of the present work is to improve understanding of the role of pressure fluctuations in the generation of coherent structures in wall-bounded turbulent flows, with particular regard to the rapid and slow source terms. The work is in part motivated by the recent numerical simulations of Sharma et al. (Phy. Fluids, 23, 2011), which showed the importance of pressure fluctuations (and their spatial gradients) in the dynamics of large-scale turbulent motions. Our experimental design consists of first generating a shearless boundary layer in a wind tunnel by passing a grid-generated turbulent flow over a moving floor whose speed is matched to the freestream velocity, and then shearing it rapidly by passing it over a stationary floor further downstream. Close to the leading edge of the stationary floor, the resulting flow is expected to satisfy the approximations of the Rapid Distortion Theory and therefore would be an ideal candidate for studying linear processes in wall turbulence. We carry out pressure measurements on the wall as well as within the flow - the former using surface mounted pressure transducers and the latter using a static pressure probe similar in design to that used by Tsuji et al. (J. Fluid. Mech. 585, 2007). We also present a comparison between the rapidly sheared flow and a more conventional boundary layer subjected to a turbulent free stream. We acknowledge the financial support from EPSRC (Grant No. EP/I037938).

Magnetism of toroidal field in two-fluid equilibrium of CHI driven spherical torus

NASA Astrophysics Data System (ADS)

Kanki, T.; Nagata, M.

2016-10-01

Double-pulsing CHI (D-CHI) experiment has been conducted in the HIST device to achieve a quasi-steady sustainment and good confinement of spherical torus (ST) plasmas. The feature of CHI driven ST such as diamagnetic toroidal field in the central open flux column (OFC) region and strong poloidal flow shear around the separatrix in the high field side suggests the two-fluid effect. The relationship between the magnetism of the toroidal field and the poloidal flow velocity is investigated by modelling the D-CHI (mainly driving the poloidal electron flow along the open flux) in the two-fluid equilibrium calculations. The poloidal component of Ampere's law leads that the toroidal field is related to the difference between the stream functions of ion ψi and electron ψe for the poloidal flow, indicating that the toroidal field with ψe >ψi results in a diamagnetic profile, while that with ψe <ψi results in a paramagnetic one. The gradient of the stream function determines the polarity and the strength of the poloidal flow velocity. It is found that the two-fluid equilibrium of CHI driven ST satisfies ψe > 0 and ψi < 0 in the OFC region, and ψe < 0 and ψi < 0 in the closed flux region. The toroidal field is a diamagnetic profile in the OFC region due to ψe >ψi and |uez | > |uiz | , where uez and uiz denote the poloidal electron and ion flow velocities, respectively. It becomes from a diamagnetic to a paramagnetic profile in the closed flux region, because ψe (uez) approaches ψi (uiz) around the magnetic axis. The poloidal ion flow shear is enhanced in the OFC region due to the ion inertial effect through the toroidal ion flow velocity.

Fluid dynamic mechanisms and interactions within separated flows

NASA Astrophysics Data System (ADS)

Dutton, J. C.; Addy, A. L.

1990-02-01

The significant results of a joint research effort investigating the fundamental fluid dynamic mechanisms and interactions within high-speed separated flows are presented in detail. The results have obtained through analytical and numerical approaches, but with primary emphasis on experimental investigations of missile and projectile base flow-related configurations. The objectives of the research program focus on understanding the component mechanisms and interactions which establish and maintain high-speed separated flow regions. The analytical and numerical efforts have centered on unsteady plume-wall interactions in rocket launch tubes and on predictions of the effects of base bleed on transonic and supersonic base flowfields. The experimental efforts have considered the development and use of a state-of-the-art two component laser Doppler velocimeter (LDV) system for experiments with planar, two-dimensional, small-scale models in supersonic flows. The LDV experiments have yielded high quality, well documented mean and turbulence velocity data for a variety of high-speed separated flows including initial shear layer development, recompression/reattachment processes for two supersonic shear layers, oblique shock wave/turbulent boundary layer interactions in a compression corner, and two-stream, supersonic, near-wake flow behind a finite-thickness base.

Virtual reality aided visualization of fluid flow simulations with application in medical education and diagnostics.

PubMed

Djukic, Tijana; Mandic, Vesna; Filipovic, Nenad

2013-12-01

Medical education, training and preoperative diagnostics can be drastically improved with advanced technologies, such as virtual reality. The method proposed in this paper enables medical doctors and students to visualize and manipulate three-dimensional models created from CT or MRI scans, and also to analyze the results of fluid flow simulations. Simulation of fluid flow using the finite element method is performed, in order to compute the shear stress on the artery walls. The simulation of motion through the artery is also enabled. The virtual reality system proposed here could shorten the length of training programs and make the education process more effective. © 2013 Published by Elsevier Ltd.

Asymmetric bubble collapse and jetting in generalized Newtonian fluids

NASA Astrophysics Data System (ADS)

Shukla, Ratnesh K.; Freund, Jonathan B.

2017-11-01

The jetting dynamics of a gas bubble near a rigid wall in a non-Newtonian fluid are investigated using an axisymmetric simulation model. The bubble gas is assumed to be homogeneous, with density and pressure related through a polytropic equation of state. An Eulerian numerical description, based on a sharp interface capturing method for the shear-free bubble-liquid interface and an incompressible Navier-Stokes flow solver for generalized fluids, is developed specifically for this problem. Detailed simulations for a range of rheological parameters in the Carreau model show both the stabilizing and destabilizing non-Newtonian effects on the jet formation and impact. In general, for fixed driving pressure ratio, stand-off distance and reference zero-shear-rate viscosity, shear-thinning and shear-thickening promote and suppress jet formation and impact, respectively. For a sufficiently large high-shear-rate limit viscosity, the jet impact is completely suppressed. Thresholds are also determined for the Carreau power-index and material time constant. The dependence of these threshold rheological parameters on the non-dimensional driving pressure ratio and wall stand-off distance is similarly established. Implications for tissue injury in therapeutic ultrasound will be discussed.

A hybrid molecular dynamics study on the non-Newtonian rheological behaviors of shear thickening fluid.

PubMed

Chen, Kaihui; Wang, Yu; Xuan, Shouhu; Gong, Xinglong

2017-07-01

To investigate the microstructural evolution dependency on the apparent viscosity in shear-thickening fluids (STFs), a hybrid mesoscale model combined with stochastic rotation dynamics (SRD) and molecular dynamics (MD) is used. Muller-Plathe reverse perturbation method is adopted to analyze the viscosities of STFs in a two-dimensional model. The characteristic of microstructural evolution of the colloidal suspensions under different shear rate is studied. The effect of diameter of colloidal particles and the phase volume fraction on the shear thickening behavior is investigated. Under low shear rate, the two-atom structure is formed, because of the strong particle attractions in adjacent layers. At higher shear rate, the synergetic pair structure extends to layered structure along flow direction because of the increasing hydrodynamics action. As the shear rate rises continuously, the layered structure rotates and collides with other particles, then turned to be individual particles under extension or curve string structure under compression. Finally, at the highest shear rate, the strings curve more severely and get into two-dimensional cluster. The apparent viscosity of the system changes from shear-thinning behavior to the shear-thickening behavior. This work presents valuable information for further understanding the shear thickening mechanism. Copyright © 2017 Elsevier Inc. All rights reserved.

Experimental study and theoretical interpretation of saturation effect on ultrasonic velocity in tight sandstones under different pressure conditions

NASA Astrophysics Data System (ADS)

Li, Dongqing; Wei, Jianxin; Di, Bangrang; Ding, Pinbo; Huang, Shiqi; Shuai, Da

2018-03-01

Understanding the influence of lithology, porosity, permeability, pore structure, fluid content and fluid distribution on the elastic wave properties of porous rocks is of great significance for seismic exploration. However, unlike conventional sandstones, the petrophysical characteristics of tight sandstones are more complex and less understood. To address this problem, we measured ultrasonic velocity in partially saturated tight sandstones under different effective pressures. A new model is proposed, combining the Mavko-Jizba-Gurevich relations and the White model. The proposed model can satisfactorily simulate and explain the saturation dependence and pressure dependence of velocity in tight sandstones. Under low effective pressure, the relationship of P-wave velocity to saturation is pre-dominantly attributed to local (pore scale) fluid flow and inhomogeneous pore-fluid distribution (large scale). At higher effective pressure, local fluid flow gradually decreases, and P-wave velocity gradually shifts from uniform saturation towards patchy saturation. We also find that shear modulus is more sensitive to saturation at low effective pressures. The new model includes wetting ratio, an adjustable parameter that is closely related to the relationship between shear modulus and saturation.

Micro-mechanics of electrostatically stabilized suspensions of cellulose nanofibrils under steady state shear flow.

PubMed

Martoïa, F; Dumont, P J J; Orgéas, L; Belgacem, M N; Putaux, J-L

2016-02-14

In this study, we characterized and modeled the rheology of TEMPO-oxidized cellulose nanofibril (NFC) aqueous suspensions with electrostatically stabilized and unflocculated nanofibrous structures. These colloidal suspensions of slender and wavy nanofibers exhibited a yield stress and a shear thinning behavior at low and high shear rates, respectively. Both the shear yield stress and the consistency of these suspensions were power-law functions of the NFC volume fraction. We developed an original multiscale model for the prediction of the rheology of these suspensions. At the nanoscale, the suspensions were described as concentrated systems where NFCs interacted with the Newtonian suspending fluid through Brownian motion and long range fluid-NFC hydrodynamic interactions, as well as with each other through short range hydrodynamic and repulsive colloidal interaction forces. These forces were estimated using both the experimental results and 3D networks of NFCs that were numerically generated to mimic the nanostructures of NFC suspensions under shear flow. They were in good agreement with theoretical and measured forces for model colloidal systems. The model showed the primary role played by short range hydrodynamic and colloidal interactions on the rheology of NFC suspensions. At low shear rates, the origin of the yield stress of NFC suspensions was attributed to the combined contribution of repulsive colloidal interactions and the topology of the entangled NFC networks in the suspensions. At high shear rates, both concurrent colloidal and short (in some cases long) range hydrodynamic interactions could be at the origin of the shear thinning behavior of NFC suspensions.

Stochastic mechanics of loose boundary particle transport in turbulent flow

NASA Astrophysics Data System (ADS)

Dey, Subhasish; Ali, Sk Zeeshan

2017-05-01

In a turbulent wall shear flow, we explore, for the first time, the stochastic mechanics of loose boundary particle transport, having variable particle protrusions due to various cohesionless particle packing densities. The mean transport probabilities in contact and detachment modes are obtained. The mean transport probabilities in these modes as a function of Shields number (nondimensional fluid induced shear stress at the boundary) for different relative particle sizes (ratio of boundary roughness height to target particle diameter) and shear Reynolds numbers (ratio of fluid inertia to viscous damping) are presented. The transport probability in contact mode increases with an increase in Shields number attaining a peak and then decreases, while that in detachment mode increases monotonically. For the hydraulically transitional and rough flow regimes, the transport probability curves in contact mode for a given relative particle size of greater than or equal to unity attain their peaks corresponding to the averaged critical Shields numbers, from where the transport probability curves in detachment mode initiate. At an inception of particle transport, the mean probabilities in both the modes increase feebly with an increase in shear Reynolds number. Further, for a given particle size, the mean probability in contact mode increases with a decrease in critical Shields number attaining a critical value and then increases. However, the mean probability in detachment mode increases with a decrease in critical Shields number.

Padé approximant for normal stress differences in large-amplitude oscillatory shear flow

NASA Astrophysics Data System (ADS)

Poungthong, P.; Saengow, C.; Giacomin, A. J.; Kolitawong, C.; Merger, D.; Wilhelm, M.

2018-04-01

Analytical solutions for the normal stress differences in large-amplitude oscillatory shear flow (LAOS), for continuum or molecular models, normally take the inexact form of the first few terms of a series expansion in the shear rate amplitude. Here, we improve the accuracy of these truncated expansions by replacing them with rational functions called Padé approximants. The recent advent of exact solutions in LAOS presents an opportunity to identify accurate and useful Padé approximants. For this identification, we replace the truncated expansion for the corotational Jeffreys fluid with its Padé approximants for the normal stress differences. We uncover the most accurate and useful approximant, the [3,4] approximant, and then test its accuracy against the exact solution [C. Saengow and A. J. Giacomin, "Normal stress differences from Oldroyd 8-constant framework: Exact analytical solution for large-amplitude oscillatory shear flow," Phys. Fluids 29, 121601 (2017)]. We use Ewoldt grids to show the stunning accuracy of our [3,4] approximant in LAOS. We quantify this accuracy with an objective function and then map it onto the Pipkin space. Our two applications illustrate how to use our new approximant reliably. For this, we use the Spriggs relations to generalize our best approximant to multimode, and then, we compare with measurements on molten high-density polyethylene and on dissolved polyisobutylene in isobutylene oligomer.

Tuning the shear viscosity of a dilute suspension using particle shapes that inhibit rotation

NASA Astrophysics Data System (ADS)

Sinai Borker, Neeraj; Stroock, Abraham; Koch, Donald

2017-11-01

We show that a suspension of slender, rigid-particles that attain an equilibrium orientation in a simple shear flow have a much smaller intrinsic viscosity relative to a suspension of tumbling particles with the same aspect ratio. An axisymmetric particle, such as a ring or a fiber, with certain cross-sections can attain an equilibrium orientation in a low Reynolds number simple shear flow without application of external forces (Singh et al., J. Fluid Mech., 2013; Bretherton, J. Fluid Mech., 1962 a). These particles align such that the slender dimension(s) of the particle is/are almost perpendicular to the velocity gradient direction of the simple shear flow and thus they have much smaller stresslets compared to the time averaged stresslet of a rotating slender particle. While slender fibers, also remain aligned in a similar state for a long time, the major contribution to the average stresslet occurs when the fiber is flipping. Using slender body theory and boundary element method calculations we demonstrate that particle alignment could significantly reduce the intrinsic viscosity of the suspension relative to a suspension of rotating particles. By choosing particle shapes that can be fabricated using manufacturing techniques such as photolithography or 3-D printing, our results open new pathways to control the rheological properties of a particle suspension by altering the shape of the particle. This research was funded by NSF Grant CBET-1435013.

Flow behaviour in normal and Meniere’s disease of endolymphatic fluid inside the inner ear

NASA Astrophysics Data System (ADS)

Paisal, Muhammad Sufyan Amir; Azmi Wahab, Muhamad; Taib, Ishkrizat; Mat Isa, Norasikin; Ramli, Yahaya; Seri, Suzairin Md; Darlis, Nofrizalidris; Osman, Kahar; Khudzari, Ahmad Zahran Md; Nordin, Normayati

2017-09-01

Meniere’s disease is a rare disorder that affects the inner ear which might be more severe if not treated. This is due to fluctuating pressure of the fluid in the endolymphatic sac and dysfunction of cochlea which causing the stretching of vestibular membrane. However, the pattern of the flow recirculation in endolymphatic region is still not fully understood. Thus, this study aims to investigate the correlation between the increasing volume of endolymphatic fluid and flow characteristics such as velocity, pressure and wall shear stress. Three dimensional model of simplified endolymphatic region is modeled using computer aided design (CAD) software and simulated using computational fluid dynamic (CFD) software. There are three different models are investigated; normal (N) model, Meniere’s disease model with less severity (M1) and Meniere’s disease model with high severity (M2). From the observed, the pressure drop between inlet and outlet of inner ear becomes decreases as the outlet pressure along with endolymphatic volume increases. However, constant flow rate imposed at the inlet of endolymphatic showing the lowest velocity. Flow recirculation near to endolymphatic region is occurred as the volume in endolympathic increases. Overall, high velocity is monitored near to cochlear duct, ductus reuniens and endolymphatic duct. Hence, these areas show high distributions of wall shear stress (WSS) that indicating a high probability of endolymphatic wall membrane dilation. Thus, more severe conditions of Meniere’s disease, more complex of flow characteristic is occurred. This phenomenon presenting high probability of rupture is predicted at the certain area in the anatomy of vestibular system.

Measurement of the Shear Lift Force on a Bubble in a Channel Flow

NASA Technical Reports Server (NTRS)

Nahra, Henry K.; Motil, Brian; Skor, Mark

2005-01-01

Two-phase flow systems play vital roles in the design of some current and anticipated space applications of two-phase systems which include: thermal management systems, transfer line flow in cryogenic storage, space nuclear power facilities, design and operation of thermal bus, life support systems, propulsion systems, In Situ Resource Utilization (ISRU), and space processes for pharmaceutical applications. The design of two-phase flow systems for space applications requires a clear knowledge of the behaviors of the dispersed phase (bubble), its interaction with the continuous phase (liquid) and its effect on heat and mass transfer processes, The need to understand the bubble generation process arises from the fact that for all space applications, the size and distribution of bubbles are extremely crucial for heat and mass transfer control. One important force in two-phase flow systems is the lift force on a bubble or particle in a liquid shear flow. The shear lift is usually overwhelmed by buoyancy in normal gravity, but it becomes an important force in reduced gravity. Since the liquid flow is usually sheared because of the confining wall, the trajectories of bubbles and particles injected into the liquid flow are affected by the shear lift in reduced gravity. A series of experiments are performed to investigate the lift force on a bubble in a liquid shear flow and its effect on the detachment of a bubble from a wall under low gravity conditions. Experiments are executed in a Poiseuille flow in a channel. An air-water system is used in these experiments that are performed in the 2.2 second drop tower. A bubble is injected into the shear flow from a small injector and the shear lift is measured while the bubble is held stationary relative to the fluid. The trajectory of the bubble prior, during and after its detachment from the injector is investigated. The measured shear lift force is calculated from the trajectory of the bubble at the detachment point. These values for the shear lift are then compared with the theoretical predictions from various published works on shear lift in the open literature, which include asymptotic solutions at low bubble Reynolds number, potential flow predictions and numerical studies that deal with intermediate bubble Reynolds numbers.

[Research advances of fluid bio-mechanics in bone].

PubMed

Chen, Zebin; Huo, Bo

2017-04-01

It has been found for more than one century that when experiencing mechanical loading, the structure of bone will adapt to the changing mechanical environment, which is called bone remodeling. Bone remodeling is charaterized as two processes of bone formation and bone resorption. A large number of studies have confirmed that the shear stress is resulted from interstitial fluid flow within bone cavities under mechanical loading and it is the key factor of stimulating the biological responses of bone cells. This review summarizes the major research progress during the past years, including the biological response of bone cells under fluid flow, the pressure within bone cavities, the theoretical modeling, numerical simulation and experiments about fluid flow within bone, and finally analyzes and predicts the possible tendency in this field in the future.

Dynamics of viscoelastic fluid filaments in microfluidic devices

NASA Astrophysics Data System (ADS)

Steinhaus, Benjamin; Shen, Amy Q.; Sureshkumar, Radhakrishna

2007-07-01

The effects of fluid elasticity and channel dimension on polymeric droplet formation in the presence of a flowing continuous Newtonian phase are investigated systematically by using different molecular weight (MW) poly(ethylene oxide) (PEO) solutions and varying microchannel dimensions with constant orifice width (w) to depth (h) ratio (w/h=1/2) and w =25μm, 50μm, 100μm, and 1mm. The flow rate is varied so that the mean shear rate is practically identical for all cases considered. Relevant times scales include inertia-capillary Rayleigh time τR=(Rmax3ρ/σ)1/2, viscocapillary Tomotika time τT=η0Rmax/σ, and the polymer relaxation time λ, where ρ is the fluid density of the dispersed phase, σ is the interfacial tension, η0 is the zero shear viscosity of the dispersed polymer phase, and Rmax is the maximum filament radius. Dimensionless numbers include the elasticity number E =λν/Rmax2, elastocapillary number Ec=λ/τT, and Deborah number, De =λ/τR, where ν =η0/ρ is the kinematic shear viscosity of the fluids. Experiments show that higher MW Boger fluids possessing longer relaxation times and larger extensional viscosities exhibit longer thread lengths and longer pinch-off times (tp). The polymer filament dynamics are controlled primarily by an elastocapillary mechanism with increasing elasticity effect at smaller length scales (larger E and Ec). However, with weaker elastic effects (i.e., larger w and lower MW), pinch-off is initiated by inertia-capillary mechanisms, followed by an elastocapillary regime. A high degree of correlation exists between the dimensionless pinch-off times and the elasticity numbers. We also observe that higher elasticity number E yields smaller effective λ. Based on the estimates of polymer scission probabilities predicted by Brownian dynamics simulations for uniaxial extensional flows, polymer chain scission is likely to occur for ultrasmall orifices and high MW fluids, yielding smaller λ. Finally, the inhibition of bead-on-a-string formation is observed only for flows with large Deborah number (De≫1).

Sheared boundary layers in turbulent Rayleigh-Benard convection

NASA Astrophysics Data System (ADS)

Solomon, T. H.; Gollub, J. P.

1990-05-01

Thermal boundary layers in turbulent Rayleigh-Benard convection are studied experimentally using a novel system in which the convecting fluid is sheared from below with a flowing layer of mercury. Oscillatory shear substantially alters the spatial structure and frequency of the eruptions, with minimal effect on the heat flux (less than 5 percent). The temperature probability distribution function (PDF) just above the lower boundary layer changes from Gaussian to exponential without significant changes in the interior PDF. Implications for theories of 'hard' turbulence are discussed.

MHD Turbulence Sheared in Fixed and Rotating Frames

NASA Technical Reports Server (NTRS)

Kassinos, S. C.; Knaepen, B.; Wray, A.

2004-01-01

We consider homogeneous turbulence in a conducting fluid that is exposed to a uniform external magnetic field while being sheared in fixed and rotating frames. We take both the frame-rotation axis and the applied magnetic field to be aligned in the direction normal to the plane of the mean shear. Here a systematic parametric study is carried out in a series of Direct Numerical Simulations (DNS) in order to clarify the main effects determining the structural anisotropy and stability of the flow.

Mean-field dynamo action in renovating shearing flows.

PubMed

Kolekar, Sanved; Subramanian, Kandaswamy; Sridhar, S

2012-08-01

We study mean-field dynamo action in renovating flows with finite and nonzero correlation time (τ) in the presence of shear. Previous results obtained when shear was absent are generalized to the case with shear. The question of whether the mean magnetic field can grow in the presence of shear and nonhelical turbulence, as seen in numerical simulations, is examined. We show in a general manner that, if the motions are strictly nonhelical, then such mean-field dynamo action is not possible. This result is not limited to low (fluid or magnetic) Reynolds numbers nor does it use any closure approximation; it only assumes that the flow renovates itself after each time interval τ. Specifying to a particular form of the renovating flow with helicity, we recover the standard dispersion relation of the α(2)Ω dynamo, in the small τ or large wavelength limit. Thus mean fields grow even in the presence of rapidly growing fluctuations, surprisingly, in a manner predicted by the standard quasilinear closure, even though such a closure is not strictly justified. Our work also suggests the possibility of obtaining mean-field dynamo growth in the presence of helicity fluctuations, although having a coherent helicity will be more efficient.

Turbulent Mixing of Primary and Secondary Flow Streams in a Rocket-Based Combined Cycle Engine

NASA Technical Reports Server (NTRS)

Cramer, J. M.; Greene, M. U.; Pal, S.; Santoro, R. J.; Turner, Jim (Technical Monitor)

2002-01-01

This viewgraph presentation gives an overview of the turbulent mixing of primary and secondary flow streams in a rocket-based combined cycle (RBCC) engine. A significant RBCC ejector mode database has been generated, detailing single and twin thruster configurations and global and local measurements. On-going analysis and correlation efforts include Marshall Space Flight Center computational fluid dynamics modeling and turbulent shear layer analysis. Potential follow-on activities include detailed measurements of air flow static pressure and velocity profiles, investigations into other thruster spacing configurations, performing a fundamental shear layer mixing study, and demonstrating single-shot Raman measurements.

Powder fed sheared dispersal particle generator

NASA Technical Reports Server (NTRS)

Morrisette, E. L.; Bushnell, D. M. (Inventor)

1984-01-01

A particle generating system is described which is capable of breaking up agglomerations of particles and producing a cloud of uniform, submicron-sized particles at high pressure and high flow rates. This is achieved by utilizing a tubular structure which has injection microslits on is periphery to accept and disperse the desired particle feed. By suppling a carrying fluid at a pressure, of approximately twice the ambient pressure of the velocimeter's settling chamber, the microslits operate at choked flow conditions. The shearing action of this choked flow is sufficient to overcome interparticle bonding forces, thereby breaking up the agglomerates of the particles feed into individual particles.

Magnetic Shear Damped Polar Convective Fluid Instabilities

NASA Astrophysics Data System (ADS)

Atul, Jyoti K.; Singh, Rameswar; Sarkar, Sanjib; Kravchenko, Oleg V.; Singh, Sushil K.; Chattopadhyaya, Prabal K.; Kaw, Predhiman K.

2018-01-01

The influence of the magnetic field shear is studied on the E × B (and/or gravitational) and the Current Convective Instabilities (CCI) occurring in the high-latitude F layer ionosphere. It is shown that magnetic shear reduces the growth rate of these instabilities. The magnetic shear-induced stabilization is more effective at the larger-scale sizes (≥ tens of kilometers) while at the scintillation causing intermediate scale sizes (˜ a few kilometers), the growth rate remains largely unaffected. The eigenmode structure gets localized about a rational surface due to finite magnetic shear and has broken reflectional symmetry due to centroid shift of the mode by equilibrium parallel flow or current.

Error analysis for reducing noisy wide-gap concentric cylinder rheometric data for nonlinear fluids - Theory and applications

NASA Technical Reports Server (NTRS)

Borgia, Andrea; Spera, Frank J.

1990-01-01

This work discusses the propagation of errors for the recovery of the shear rate from wide-gap concentric cylinder viscometric measurements of non-Newtonian fluids. A least-square regression of stress on angular velocity data to a system of arbitrary functions is used to propagate the errors for the series solution to the viscometric flow developed by Krieger and Elrod (1953) and Pawlowski (1953) ('power-law' approximation) and for the first term of the series developed by Krieger (1968). A numerical experiment shows that, for measurements affected by significant errors, the first term of the Krieger-Elrod-Pawlowski series ('infinite radius' approximation) and the power-law approximation may recover the shear rate with equal accuracy as the full Krieger-Elrod-Pawlowski solution. An experiment on a clay slurry indicates that the clay has a larger yield stress at rest than during shearing, and that, for the range of shear rates investigated, a four-parameter constitutive equation approximates reasonably well its rheology. The error analysis presented is useful for studying the rheology of fluids such as particle suspensions, slurries, foams, and magma.

Structure-rheology relationship in a sheared lamellar fluid.

PubMed

Jaju, S J; Kumaran, V

2016-03-01

The structure-rheology relationship in the shear alignment of a lamellar fluid is studied using a mesoscale model which provides access to the lamellar configurations and the rheology. Based on the equations and free energy functional, the complete set of dimensionless groups that characterize the system are the Reynolds number (ργL(2)/μ), the Schmidt number (μ/ρD), the Ericksen number (μγ/B), the interface sharpness parameter r, the ratio of the viscosities of the hydrophilic and hydrophobic parts μ(r), and the ratio of the system size and layer spacing (L/λ). Here, ρ and μ are the fluid density and average viscosity, γ is the applied strain rate, D is the coefficient of diffusion, B is the compression modulus, μ(r) is the maximum difference in the viscosity of the hydrophilic and hydrophobic parts divided by the average viscosity, and L is the system size in the cross-stream direction. The lattice Boltzmann method is used to solve the concentration and momentum equations for a two dimensional system of moderate size (L/λ=32) and for a low Reynolds number, and the other parameters are systematically varied to examine the qualitative features of the structure and viscosity evolution in different regimes. At low Schmidt numbers where mass diffusion is faster than momentum diffusion, there is fast local formation of randomly aligned domains with "grain boundaries," which are rotated by the shear flow to align along the extensional axis as time increases. This configuration offers a high resistance to flow, and the layers do not align in the flow direction even after 1000 strain units, resulting in a viscosity higher than that for an aligned lamellar phase. At high Schmidt numbers where momentum diffusion is fast, the shear flow disrupts layers before they are fully formed by diffusion, and alignment takes place by the breakage and reformation of layers by shear, resulting in defects (edge dislocations) embedded in a background of nearly aligned layers. At high Ericksen number where the viscous forces are large compared to the restoring forces due to layer compression and bending, shear tends to homogenize the concentration field, and the viscosity decreases significantly. At very high Ericksen number, shear even disrupts the layering of the lamellar phase. At low Ericksen number, shear results in the formation of well aligned layers with edge dislocations. However, these edge dislocations take a long time to anneal; the relatively small misalignment due to the defects results in a large increase in viscosity due to high layer stiffness and due to shear localization, because the layers between defects get pinned and move as a plug with no shear. An increase in the viscosity contrast between the hydrophilic and hydrophobic parts does not alter the structural characteristics during alignment. However, there is a significant increase in the viscosity, due to pinning of the layers between defects, which results in a plug flow between defects and a localization of the shear to a part of the domain.

Normal stresses in shear thickening granular suspensions.

PubMed

Pan, Zhongcheng; de Cagny, Henri; Habibi, Mehdi; Bonn, Daniel

2017-05-24

When subjected to shear, granular suspensions exhibit normal stresses perpendicular to the shear plane but the magnitude and sign of the different components of the normal stresses are still under debate. By performing both oscillatory and rotational rheology measurements on shear thickening granular suspensions and systematically varying the particle diameters and the gap sizes between two parallel-plates, we show that a transition from a positive to a negative normal stress can be observed. We find that frictional interactions which determine the shear thickening behavior of suspensions contribute to the positive normal stresses. Increasing the particle diameters or decreasing the gap sizes leads to a growing importance of hydrodynamic interactions, which results in negative normal stresses. We determine a relaxation time for the system, set by both the pore and the gap sizes, that governs the fluid flow through the inter-particle space. Finally, using a two-fluid model we determine the relative contributions from the particle phase and the liquid phase.

Sustained expression of MCP-1 by low wall shear stress loading concomitant with turbulent flow on endothelial cells of intracranial aneurysm.

PubMed

Aoki, Tomohiro; Yamamoto, Kimiko; Fukuda, Miyuki; Shimogonya, Yuji; Fukuda, Shunichi; Narumiya, Shuh

2016-05-09

Enlargement of a pre-existing intracranial aneurysm is a well-established risk factor of rupture. Excessive low wall shear stress concomitant with turbulent flow in the dome of an aneurysm may contribute to progression and rupture. However, how stress conditions regulate enlargement of a pre-existing aneurysm remains to be elucidated. Wall shear stress was calculated with 3D-computational fluid dynamics simulation using three cases of unruptured intracranial aneurysm. The resulting value, 0.017 Pa at the dome, was much lower than that in the parent artery. We loaded wall shear stress corresponding to the value and also turbulent flow to the primary culture of endothelial cells. We then obtained gene expression profiles by RNA sequence analysis. RNA sequence analysis detected hundreds of differentially expressed genes among groups. Gene ontology and pathway analysis identified signaling related with cell division/proliferation as overrepresented in the low wall shear stress-loaded group, which was further augmented by the addition of turbulent flow. Moreover, expression of some chemoattractants for inflammatory cells, including MCP-1, was upregulated under low wall shear stress with concomitant turbulent flow. We further examined the temporal sequence of expressions of factors identified in an in vitro study using a rat model. No proliferative cells were detected, but MCP-1 expression was induced and sustained in the endothelial cell layer. Low wall shear stress concomitant with turbulent flow contributes to sustained expression of MCP-1 in endothelial cells and presumably plays a role in facilitating macrophage infiltration and exacerbating inflammation, which leads to enlargement or rupture.

Flow-dependent regulation of endothelial nitric oxide synthase: role of protein kinases

NASA Technical Reports Server (NTRS)

Boo, Yong Chool; Jo, Hanjoong

2003-01-01

Vascular endothelial cells are directly and continuously exposed to fluid shear stress generated by blood flow. Shear stress regulates endothelial structure and function by controlling expression of mechanosensitive genes and production of vasoactive factors such as nitric oxide (NO). Though it is well known that shear stress stimulates NO production from endothelial nitric oxide synthase (eNOS), the underlying molecular mechanisms remain unclear and controversial. Shear-induced production of NO involves Ca2+/calmodulin-independent mechanisms, including phosphorylation of eNOS at several sites and its interaction with other proteins, including caveolin and heat shock protein-90. There have been conflicting results as to which protein kinases-protein kinase A, protein kinase B (Akt), other Ser/Thr protein kinases, or tyrosine kinases-are responsible for shear-dependent eNOS regulation. The functional significance of each phosphorylation site is still unclear. We have attempted to summarize the current status of understanding in shear-dependent eNOS regulation.

Shear Wave Splitting Inversion in a Complex Crust

NASA Astrophysics Data System (ADS)

Lucas, A.

2015-12-01

Shear wave splitting (SWS) inversion presents a method whereby the upper crust can be interrogated for fracture density. It is caused when a shear wave traverses an area of anisotropy, splits in two, with each wave experiencing a different velocity resulting in an observable separation in arrival times. A SWS observation consists of the first arrival polarization direction and the time delay. Given the large amount of data common in SWS studies, manual inspection for polarization and time delay is considered prohibitively time intensive. All automated techniques used can produce high amounts of observations falsely interpreted as SWS. Thus introducing error into the interpretation. The technique often used for removing these false observations is to manually inspect all SWS observations defined as high quality by the automated routine, and remove false identifications. We investigate the nature of events falsely identified compared to those correctly identified. Once this identification is complete we conduct a inversion for crack density from SWS time delay. The current body of work on linear SWS inversion utilizes an equation that defines the time delay between arriving shear waves with respect to fracture density. This equation makes the assumption that no fluid flow occurs as a result of the passing shear wave, a situation called squirt flow. We show that the assumption is not applicable in all geological situations. When it is not true, its use in an inversion produces a result which is negatively affected by the assumptions. This is shown to be the case at the test case of 6894 SWS observations gathered in a small area at Puna geothermal field, Hawaii. To rectify this situation, a series of new time delay formulae, applicable to linear inversion, are derived from velocity equations presented in literature. The new formula use a 'fluid influence parameter' which indicates the degree to which squirt flow is influencing the SWS. It is found that accounting for squirt flow better fits the data and is more applicable. The fluid influence factor that best describes the data can be identified prior to solving the inversion. Implementing this formula in a linear inversion has a significantly improved fit to the time delay observations than that of the current methods.

Identification of the Viscous Superlayer on the Low-Speed Side of a Single-Stream Shear Layer

NASA Astrophysics Data System (ADS)

Foss, John; Peabody, Jason

2010-11-01

Image pairs (elevation/plan views) have been acquired of a smoke streakline originating in the irrotational region on the low-speed side of a high Re single-stream shear layer of Morris and Foss (2003). The viscous superlayer (VSL) is identified as the terminus of the streak; 1800 such images provide VSL position statistics. Hot-wire data acquired concurrently at the shear layer edge and interior are used to investigate the relationship between these velocity magnitudes and the large-scale motions. Distinctive features (plumes) along the streakline are tracked between images to provide discrete irrotational region velocity magnitudes and material trajectories. A non-diffusive marker, introduced in the separating (high speed) boundary layer and imaged at x/θo=352, has revealed an unexpected bias in the streak-defined VSL locations. The interpretation of this bias clarifies the induced flow patterns in the entrainment region. The observations are consistent with a conception of the large-scale shear layer motions as "billows" of vortical fluid separated by re-entrant "wedges" of irrotational fluid, per Phillips (1972). Morris, S.C. and Foss, J.F. (2003). "Turbulent Boundary Layer to Single Stream Shear Layer: The Transition Region." Journal of Fluid Mechanics. Vol. 494, pp. 187-221. Phillips, O. M. (1972). "The Entrainment Interface." Journal of Fluid Mechanics. Vol. 51, pp. 97-118.

Characterisation of minimal-span plane Couette turbulence with pressure gradients

NASA Astrophysics Data System (ADS)

Sekimoto, Atsushi; Atkinson, Callum; Soria, Julio

2018-04-01

The turbulence statistics and dynamics in the spanwise-minimal plane Couette flow with pressure gradients, so-called, Couette-Poiseuille (C-P) flow, are investigated using direct numerical simulation. The large-scale motion is limited in the spanwise box dimension as in the minimal-span channel turbulence of Flores & Jiménez (Phys. Fluids, vol. 22, 2010, 071704). The effect of the top wall, where normal pressure-driven Poiseuille flow is realised, is distinguished from the events on the bottom wall, where the pressure gradient results in mild or almost-zero wall-shear stress. A proper scaling of turbulence statistics in minimal-span C-P flows is presented. Also the ‘shear-less’ wall-bounded turbulence, where the Corrsin shear parameter is very weak compared to normal wall-bounded turbulence, represents local separation, which is also observed as spanwise streaks of reversed flow in full-size plane C-P turbulence. The local separation is a multi-scale event, which grows up to the order of the channel height even in the minimal-span geometry.

Structure of the Small Amplitude Motion on Transversely Sheared Mean Flows

NASA Technical Reports Server (NTRS)

Goldstein, Marvin E.; Afsar, Mohamed Z.; Leib, Stewart J.

2013-01-01

This paper considers the small amplitude unsteady motion of an inviscid non-heat conducting compressible fluid on a transversely sheared mean flow. It extends a previous result given in Goldstein (1978(b) and 1979(a)) which shows that the hydrodynamic component of the motion is determined by two arbitrary convected quantities in the absence of solid surfaces or other external sources. The result is important because it can be used to specify appropriate boundary conditions for unsteady surface interaction problems on transversely sheared mean flows in the same way that the vortical component of the Kovasznay (1953) decomposition is used to specify these conditions for surface interaction problems on uniform mean flows. But unlike the Kovasznay (1953) case the arbitrary convected quantities no longer bear a simple relation to the physical variables. One purpose of this paper is to derive a formula that relates these quantities to the (physically measurable) vorticity and pressure fluctuations in the flow.

Dilatancy and shear thickening of particle suspensions

NASA Astrophysics Data System (ADS)

Bonn, Daniel

2013-03-01

Shear thickening is a fascinating subject, as 99.9% of complex fluids are thinning; thickening systems thus are the ``exception to the rule'' that needs to be understood. Moreover, such tunable systems show very promising applications, e.g. to block large underground pores in oil recovery to maintain a constant oil flow by plugging water filled pores (an approach used in oil recovery by e.g. Shell), or to manufacture bulletproof vests that are comfortable to wear, but stop bullets nonetheless. We study the rheology of non-Brownian particle suspensions (notably, cornstarch) that exhibit shear thickening. Using magnetic resonance imaging (MRI), the local properties of the flow are obtained by the determination of local velocity profiles and concentrations in a Couette cell. We also perform macroscopic rheology experiments in different geometries. The results suggest that the shear thickening is a consequence of dilatancy: the system under flow attempts to dilate but instead undergoes a jamming transition, because it is confined. This proposition is confirmed by an independent measurement of the dilation of the suspension as a function of the shear rate.

Relaxation-type nonlocal inertial-number rheology for dry granular flows

NASA Astrophysics Data System (ADS)

Lee, Keng-lin; Yang, Fu-ling

2017-12-01

We propose a constitutive model to describe the nonlocality, hysteresis, and several flow features of dry granular materials. Taking the well-known inertial number I as a measure of sheared-induced local fluidization, we derive a relaxation model for I according to the evolution of microstructure during avalanche and dissipation processes. The model yields a nonmonotonic flow law for a homogeneous flow, accounting for hysteretic solid-fluid transition and intermittency in quasistatic flows. For an inhomogeneous flow, the model predicts a generalized Bagnold shear stress revealing the interplay of two microscopic nonlocal mechanisms: collisions among correlated structures and the diffusion of fluidization within the structures. In describing a uniform flow down an incline, the model reproduces the hysteretic starting and stopping heights and the Pouliquen flow rule for mean velocity. Moreover, a dimensionless parameter reflecting the nonlocal effect on the flow is discovered, which controls the transition between Bagnold and creeping flow dynamics.

Experimental and numerical models of three-dimensional gravity-driven flow of shear-thinning polymer solutions used in vaginal delivery of microbicides.

PubMed

Kheyfets, Vitaly O; Kieweg, Sarah L

2013-06-01

HIV/AIDS is a growing global pandemic. A microbicide is a formulation of a pharmaceutical agent suspended in a delivery vehicle, and can be used by women to protect themselves against HIV infection during intercourse. We have developed a three-dimensional (3D) computational model of a shear-thinning power-law fluid spreading under the influence of gravity to represent the distribution of a microbicide gel over the vaginal epithelium. This model, accompanied by a new experimental methodology, is a step in developing a tool for optimizing a delivery vehicle's structure/function relationship for clinical application. We compare our model with experiments in order to identify critical considerations for simulating 3D free-surface flows of shear-thinning fluids. Here we found that neglecting lateral spreading, when modeling gravity-induced flow, resulted in up to 47% overestimation of the experimental axial spreading after 90 s. In contrast, the inclusion of lateral spreading in 3D computational models resulted in rms errors in axial spreading under 7%. In addition, the choice of the initial condition for shape in the numerical simulation influences the model's ability to describe early time spreading behavior. Finally, we present a parametric study and sensitivity analysis of the power-law parameters' influence on axial spreading, and to examine the impact of changing rheological properties as a result of dilution or formulation conditions. Both the shear-thinning index (n) and consistency (m) impacted the spreading length and deceleration of the moving front. The sensitivity analysis showed that gels with midrange m and n values (for the ranges in this study) would be most sensitive (over 8% changes in spreading length) to 10% changes (e.g., from dilution) in both rheological properties. This work is applicable to many industrial and geophysical thin-film flow applications of non-Newtonian fluids; in addition to biological applications in microbicide drug delivery.

Experimental and Numerical Models of Three-Dimensional Gravity-Driven Flow of Shear-Thinning Polymer Solutions Used in Vaginal Delivery of Microbicides

PubMed Central

Kheyfets, Vitaly O.; Kieweg, Sarah L.

2013-01-01

HIV/AIDS is a growing global pandemic. A microbicide is a formulation of a pharmaceutical agent suspended in a delivery vehicle, and can be used by women to protect themselves against HIV infection during intercourse. We have developed a three-dimensional (3D) computational model of a shear-thinning power-law fluid spreading under the influence of gravity to represent the distribution of a microbicide gel over the vaginal epithelium. This model, accompanied by a new experimental methodology, is a step in developing a tool for optimizing a delivery vehicle's structure/function relationship for clinical application. We compare our model with experiments in order to identify critical considerations for simulating 3D free-surface flows of shear-thinning fluids. Here we found that neglecting lateral spreading, when modeling gravity-induced flow, resulted in up to 47% overestimation of the experimental axial spreading after 90 s. In contrast, the inclusion of lateral spreading in 3D computational models resulted in rms errors in axial spreading under 7%. In addition, the choice of the initial condition for shape in the numerical simulation influences the model's ability to describe early time spreading behavior. Finally, we present a parametric study and sensitivity analysis of the power-law parameters' influence on axial spreading, and to examine the impact of changing rheological properties as a result of dilution or formulation conditions. Both the shear-thinning index (n) and consistency (m) impacted the spreading length and deceleration of the moving front. The sensitivity analysis showed that gels with midrange m and n values (for the ranges in this study) would be most sensitive (over 8% changes in spreading length) to 10% changes (e.g., from dilution) in both rheological properties. This work is applicable to many industrial and geophysical thin-film flow applications of non-Newtonian fluids; in addition to biological applications in microbicide drug delivery. PMID:23699721

A displacement-pressure finite element formulation for analyzing the sound transmission in ducted shear flows with finite poroelastic lining.

PubMed

Nennig, Benoit; Tahar, Mabrouk Ben; Perrey-Debain, Emmanuel

2011-07-01

In the present work, the propagation of sound in a lined duct containing sheared mean flow is studied. Walls of the duct are acoustically treated with absorbent poroelastic foams. The propagation of elasto-acoustic waves in the liner is described by Biot's model. In the fluid domain, the propagation of sound in a sheared mean flow is governed by the Galbrun's equation. The problem is solved using a mixed displacement-pressure finite element formulation in both domains. A 3D implementation of the model has been performed and is illustrated on axisymmetric examples. Convergence and accuracy of the numerical model are shown for the particular case of the modal propagation in a infinite duct containing a uniform flow. Practical examples concerning the sound attenuation through dissipative silencers are discussed. In particular, effects of the refraction effects in the shear layer as well as the mounting conditions of the foam on the transmission loss are shown. The presence of a perforate screen at the air-porous interface is also considered and included in the model. © 2011 Acoustical Society of America

Sensor for Direct Measurement of the Boundary Shear Stress in Fluid Flow

NASA Technical Reports Server (NTRS)

Bao, Xiaoqi; Badescu, Mircea; Bar-Cohen, Yoseph; Lih, Shyh-Shiuh; Sherrit, Stewart; Chang, Zensheu; Chen, Beck; Widholm, Scott; Ostlund, Patrick

2011-01-01

The formation of scour patterns at bridge piers is driven by the forces at the boundary of the water flow. In most experimental scour studies, indirect processes have been applied to estimate the shear and normal stress using measured velocity profiles. The estimations are based on theoretical models and associated assumptions. However, the turbulence flow fields and boundary layer in the pier-scour region are very complex. In addition, available turbulence models cannot account accurately for the bed roughness effect. Direct measurement of the boundary shear and normal stress and their fluctuations are attractive alternatives. However, this approach is a challenging one especially for high spatial resolution and high fidelity measurements. The authors designed and fabricated a prototype miniature shear stress sensor including an EDM machined floating plate and a high-resolution laser optical encoder. Tests were performed both in air as well as operation in water with controlled flow. The sensor sensitivity, stability and signal-to-noise level were measured and evaluated. The detailed test results and a discussion of future work will be presented in this paper.

A comprehensive constitutive law for waxy crude oil: a thixotropic yield stress fluid.

PubMed

Dimitriou, Christopher J; McKinley, Gareth H

2014-09-21

Guided by a series of discriminating rheometric tests, we develop a new constitutive model that can quantitatively predict the key rheological features of waxy crude oils. We first develop a series of model crude oils, which are characterized by a complex thixotropic and yielding behavior that strongly depends on the shear history of the sample. We then outline the development of an appropriate preparation protocol for carrying out rheological measurements, to ensure consistent and reproducible initial conditions. We use RheoPIV measurements of the local kinematics within the fluid under imposed deformations in order to validate the selection of a particular protocol. Velocimetric measurements are also used to document the presence of material instabilities within the model crude oil under conditions of imposed steady shearing. These instabilities are a result of the underlying non-monotonic steady flow curve of the material. Three distinct deformation histories are then used to probe the material's constitutive response. These deformations are steady shear, transient response to startup of steady shear with different aging times, and large amplitude oscillatory shear (LAOS). The material response to these three different flows is used to motivate the development of an appropriate constitutive model. This model (termed the IKH model) is based on a framework adopted from plasticity theory and implements an additive strain decomposition into characteristic reversible (elastic) and irreversible (plastic) contributions, coupled with the physical processes of isotropic and kinematic hardening. Comparisons of experimental to simulated response for all three flows show good quantitative agreement, validating the chosen approach for developing constitutive models for this class of materials.

Shear-induced partial translational ordering of a colloidal solid

NASA Astrophysics Data System (ADS)

Ackerson, B. J.; Clark, N. A.

1984-08-01

Highly charged submicrometer plastic spheres suspended in water at low ionic strength will order spontaneously into bcc crystals or polycrystals. A simple linear shear orients and disorders these crystals by forcing (110) planes to stack normal to the shear gradient and to slide relative to each other with a <111> direction parallel to the solvent flow. In this paper we analyze in detail the disordering and flow processes occurring beyond the intrinsic elastic limit of the bcc crystal. We are led to a model in which the flow of a colloidal crystal is interpreted as a fundamentally different process from that found in atomic crystals. In the colloidal crystal the coupling of particle motion to the background fluid forces a homogeneous flow, where every layer is in motion relative to its neighboring layers. In contrast, the plastic flow in an atomic solid is defect mediated flow. At the lowest applied stress, the local bcc order in the colloidal crystal exhibits shear strains both parallel and perpendicular to the direction of the applied stress. The magnitude of these deformations is estimated using the configurational energy for bcc and distorted bcc crystals, assuming a screened Coulomb pair interaction between colloidal particles. As the applied stress is increased, the intrinsic elastic limit of the crystal is exceeded and the crystal begins to flow with adjacent layers executing an oscillatory path governed by the balance of viscous and screened Coulomb forces. The path takes the structure from the bcc1 and bcc2 twins observed at zero shear to a distorted two-dimensional hcp structure at moderate shear rates, with a loss of interlayer registration as the shear is increased. This theoretical model is consistent with other experimental observations, as well.

Fluid Enhanced Deformation and Metamorphism in Exhumed Lower Crust from the Northern Madison Range, Southwestern Montana, USA

NASA Astrophysics Data System (ADS)

Condit, Cailey Brown

Deep crustal processes during collisional orogenesis exert first-order controls on the development, scale and behavior of an orogenic belt. The presence or absence of fluids play important roles in these processes by enhancing deformation, catalyzing chemical reactions, and facilitating wholesale alteration of lithologic properties. However, the scales over which these fluid-related interactions occur and the specific feedbacks among them remain poorly constrained. The late Paleoproterozoic Big Sky orogen, expressed as high-grade deep crust exposed in the Laramide basement-cored uplifts of SW Montana, USA, offers an exceptional natural laboratory to address some of these questions. New data are presented from field and structural analysis, petrology, geochemistry, and geochronology in the Northern Madison Range, a key locality for constraining the hinterland-foreland transition of the orogen. Combined with other regional data, the age of high-grade metamorphism youngs by 80-40 Myr across an 100 km transect suggesting propagation of the orogenic core towards its foreland over time. In the southeastern part of the Northern Madison Range, two domains separated by a km-scale ductile shear zone, were transformed by hydrous fluids at significantly different spatial scales. The Gallatin Peak terrane was widely metamorphosed, metasomatized, and penetratively deformed in the presence of fluids at upper amphibolite facies during the Big Sky orogeny. Together, these data suggest that this area was pervasively hydrated and deformed over scales of several kilometers during thermotectonism at 30-25 km paleodepths. In the Moon Lake block, fluid flow at similar crustal depths and temperatures played a more localized but equally important role. Discrete flow along brittle fractures in metagabbronorite dikes led to nucleation of cm-scale ductile shear zones and metasomatic alteration. A model for shear zone evolution is presented that requires feedbacks between mechanical and chemical processes for strain localization. Seismic anisotropy was calculated for one of these shear zones. Deformation-induced crystallographic preferred orientation (CPO) of anisotropic minerals typically produces seismic anisotropy in the deep crust. However, this shear zone deformed by mechanisms that yielded no significant CPO, in part due to the fluid-rich environment, and very low seismic anisotropy, suggesting that high anisotropy does not always correlate with high strain.

Utility of Squeeze Flow in the Food Industry

NASA Astrophysics Data System (ADS)

Huang, T. A.

2008-07-01

Squeeze flow for obtaining shear viscosity on Newtonian and non-Newtonian fluids has long been established in the literature. Rotational shear flow using cone/plate, a set of parallel plates, or concentric cylinders all develop wall slip, shear fracture, or instability on food related materials such as peanut butter or mayonnaise. Viscosity data obtained using any one of the above mentioned set-ups is suspect or potentially results in significant error. They are unreliable to support or predict the textural differences perceived by consumer evaluation. RMS-800, from Rheometrics Inc., was employed to conduct the squeezing flow under constant speeds on a set of parallel plates. Viscosity data, over a broad range of shear rates, is compared between Hellmann's real (HRM) and light mayonnaise (HLM). The Consistency and shear-thinning indices, as defined in the Power-Law Model, were determined. HRM exhibits a more pronounced shear-thinning when compared to HLM yet the Consistency of HRM is significantly higher. Sensory evaluation by a trained expert panel ranked that adhesiveness and cohesiveness of HLM are significantly higher. It appears that the degree of shear thinning is one of the key rheological parameters in predicting the above mentioned difference in textural attributes. Error involved in determining viscosity from non-parallelism between two plates can be significant to affect the accuracy of the viscosity, in particular, shear-thinning index. Details are a subject for the next presentation. Nevertheless, the method is proven to be fast, rugged, simple, and reliable. It can be developed as a QC tool.

A numerical study of a long flexible fiber in shear flow: dynamics and rheology

NASA Astrophysics Data System (ADS)

Zuk, Pawel; Perazzo, Antonio; Nunes, Janine; Stone, Howard

2017-11-01

Long slender particles can span the whole spectrum of stiffness: from very flexible particles such as globular proteins to extremely rigid particles, e.g. carbon nanotubes or β-amyloid fibers. The behavior of rigid particles is well understood, however there are only few recent experimental reports about long fibers of moderate flexibility. We present a numerical study of a single long flexible fiber in a shear flow. The fiber is simulated as a bead-spring model including hydrodynamic interactions in the Rotne-Prager-Yamakawa approximation. We analyze fiber shape, motion and stress induced in the fluid under the shear flow. We find that all of these properties appear to be related to the characteristic length scale of the kinks formed in the fibers. We present a scaling law for the kink size as a function of shear rate and the fiber parameters and justify it using elastic theory. The study suggests that local properties of a single fiber may condition the behavior of concentrated suspensions.

Combined effects on MHD flow of Newtonian fluid past infinite vertical porous plate

NASA Astrophysics Data System (ADS)

Subbanna, K.; Mohiddin, S. Gouse; Vijaya, R. Bhuvana

2018-05-01

In this paper, we discussed free convective flow of a viscous fluid past an infinite vertical porous plate under the influence of uniform transverse magnetic field. Time dependent permeability and oscillatory suction is considered. The equations of the flow field are solved by a routine perturbation method for small amplitude of the permeability. The solutions for the velocity, temperature and concentration have been derived analytically and also its behavior is computationally discussed with the help of profiles. The shear stress, the Nusselt number and Sherwood number are also obtained and their behavior discussed computationally

Molecular structural property and potential energy dependence on nonequilibrium-thermodynamic state point of liquid n-hexadecane under shear.

PubMed

Tseng, Huan-Chang; Chang, Rong-Yeu; Wu, Jiann-Shing

2011-01-28

Extensive computer experiments have been conducted in order to shed light on the macroscopic shear flow behavior of liquid n-hexadecane fluid under isobaric-isothermal conditions through the nonequilibrium molecular dynamic methodology. With respect to shear rates, the accompanying variations in structural properties of the fluid span the microscopic range of understanding from the intrinsic to extrinsic characteristics. As drawn from the average value of bond length and bond angle, the distribution of dihedral angle, and the radius distribution function of intramolecular and intermolecular van der Waals distances, these intrinsic structures change with hardness, except in the situation of extreme shear rates. The shear-induced variation of thermodynamic state curve along with the shear rate studied is shown to consist of both the quasiequilibrium state plateau and the nonequilibrium-thermodynamic state slope. Significantly, the occurrence of nonequilibrium-thermodynamic state behavior is attributed to variations in molecular potential energies, which include bond stretching, bond bending, bond torsion, and intra- and intermolecular van der Waals interactions. To unfold the physical representation of extrinsic structural deformation, under the aggressive influence of a shear flow field, the molecular dimension and appearance can be directly described via the squared radius of gyration and the sphericity angle, R(g)(2) and ϕ, respectively. In addition, a specific orientational order S(x) defines the alignment of the molecules with the flow direction of the x-axis. As a result, at low shear rates, the overall molecules are slightly stretched and shaped in a manner that is increasingly ellipsoidal. Simultaneously, there is an obvious enhancement in the order. In contrast to high shear rates, the molecules spontaneously shrink themselves with a decreased value of R(g)(2), while their shape and order barely vary with an infinite value of ϕ and S(x). It is important to note that under different temperatures and pressures, these three parameters are integrated within a molecular description in response to thermodynamic state variable of density and rheological material function of shear viscosity.

By activating matrix metalloproteinase-7, shear stress promotes chondrosarcoma cell motility, invasion and lung colonization.

PubMed

Guan, Pei-Pei; Yu, Xin; Guo, Jian-Jun; Wang, Yue; Wang, Tao; Li, Jia-Yi; Konstantopoulos, Konstantinos; Wang, Zhan-You; Wang, Pu

2015-04-20

Interstitial fluid flow and associated shear stress are relevant mechanical signals in cartilage and bone (patho)physiology. However, their effects on chondrosarcoma cell motility, invasion and metastasis have yet to be delineated. Using human SW1353, HS.819.T and CH2879 chondrosarcoma cell lines as model systems, we found that fluid shear stress induces the accumulation of cyclic AMP (cAMP) and interleukin-1β (IL-1β), which in turn markedly enhance chondrosarcoma cell motility and invasion via the induction of matrix metalloproteinase-7 (MMP-7). Specifically, shear-induced cAMP and IL-1β activate PI3-K, ERK1/2 and p38 signaling pathways, which lead to the synthesis of MMP-7 via transactivating NF-κB and c-Jun in human chondrosarcoma cells. Importantly, MMP-7 upregulation in response to shear stress exposure has the ability to promote lung colonization of chondrosarcomas in vivo. These findings offer a better understanding of the mechanisms underlying MMP-7 activation in shear-stimulated chondrosarcoma cells, and provide insights on designing new therapeutic strategies to interfere with chondrosarcoma invasion and metastasis.

A study on the unsteady flow of two immiscible micropolar and Newtonian fluids through a horizontal channel: A numerical approach

NASA Astrophysics Data System (ADS)

Devakar, M.; Raje, Ankush

2018-05-01

The unsteady flow of two immiscible micropolar and Newtonian fluids through a horizontal channel is considered. In addition to the classical no-slip and hyper-stick conditions at the boundary, it is assumed that the fluid velocities and shear stresses are continuous across the fluid-fluid interface. Three cases for the applied pressure gradient are considered to study the problem: one with constant pressure gradient and the other two cases with time-dependent pressure gradients, viz. periodic and decaying pressure gradient. The Crank-Nicolson approach has been used to obtain numerical solutions for fluid velocity and microrotation for diverse sets of fluid parameters. The nature of fluid velocities and microrotation with various values of pressure gradient, Reynolds number, ratio of viscosities, micropolarity parameter and time is illustrated through graphs. It has been observed that micropolarity parameter and ratio of viscosities reduce the fluid velocities.

Rheological study of synovial fluid obtained from dogs: healthy, pathological, and post-surgery, after spontaneous rupture of cranial cruciate ligament.

PubMed

Goudoulas, Thomas B; Kastrinakis, Eleftherios G; Nychas, Stavros G; Papazoglou, Lysimachos G; Kazakos, George M; Kosmas, Panagiotis V

2010-01-01

In the present study synovial fluid (SF) obtained from the stifle joint of healthy adult dogs and of dogs after cranial cruciate ligament rupture was analyzed regarding its rheological characteristics according to the condition of the joint. The viscoelastic and shear flow properties were measured at 25 and 38 degrees C. The results showed that the healthy SF exhibits practically temperature independent viscosity curve and satisfactory viscoelastic characteristics, i.e. G' > G'', over frequencies of 0.05-5 Hz, and characteristic relaxation time lambda of the order of magnitude of 100 s. Creep measurements demonstrate that the zero shear viscosity was in the range of 10-100 Pa s. In shear flow viscosity measurements, by increasing gamma from 10(-4) s(-1) up to 10(3) s(-1), non-Newtonian shear thinning behavior was observed and the viscosity values were decreased from 10(3) to 0.1 Pa s. On the contrary, in pathological conditions of cranial cruciate ligament rupture (CCLR), the measured viscosity was found drastically reduced, i.e. between 100 and 10 mPa s. The CCLR synovial fluid, similar to healthy SF, exhibits insignificant temperature dependence. The present study showed also that about one week after a surgery for CCLR repair the SF exhibits non-Newtonian behavior of dilute polymers. After two weeks from the operation, however, the rheological behavior converges to the one of healthy SF.

A Numerical Study of Mesh Adaptivity in Multiphase Flows with Non-Newtonian Fluids

NASA Astrophysics Data System (ADS)

Percival, James; Pavlidis, Dimitrios; Xie, Zhihua; Alberini, Federico; Simmons, Mark; Pain, Christopher; Matar, Omar

2014-11-01

We present an investigation into the computational efficiency benefits of dynamic mesh adaptivity in the numerical simulation of transient multiphase fluid flow problems involving Non-Newtonian fluids. Such fluids appear in a range of industrial applications, from printing inks to toothpastes and introduce new challenges for mesh adaptivity due to the additional ``memory'' of viscoelastic fluids. Nevertheless, the multiscale nature of these flows implies huge potential benefits for a successful implementation. The study is performed using the open source package Fluidity, which couples an unstructured mesh control volume finite element solver for the multiphase Navier-Stokes equations to a dynamic anisotropic mesh adaptivity algorithm, based on estimated solution interpolation error criteria, and conservative mesh-to-mesh interpolation routine. The code is applied to problems involving rheologies ranging from simple Newtonian to shear-thinning to viscoelastic materials and verified against experimental data for various industrial and microfluidic flows. This work was undertaken as part of the EPSRC MEMPHIS programme grant EP/K003976/1.

Fluid Shearing for Accelerated Chemical Reactions - Fluid Mechanics in the VFD

NASA Astrophysics Data System (ADS)

Leivadarou, Evgenia; Dalziel, Stuart; G. K. Batchelor Laboratory, Department of Applied Mathematics; Theoretical Physics Team

2016-11-01

The Vortex Fluidic Device (VFD) is a rapidly rotating tube that can operate under continuous flow with a jet feeding liquid reactants to the tube's hemispherical base. It is a new 'green' approach to the organic synthesis with many industrial applications in cosmetics, protein folding and pharmaceutical production. The rate of reaction in the VFD is enhanced when the collision rate is increased. The aim of the project is to explain the fluid mechanics and optimize the performance of the device. One contribution to the increased yield is believed to be the high levels of shear stress. We attempt to enhance the shear stress by achieving high velocity gradients in the boundary layers. Another factor is the uncontrolled vibrations due to imperfections in the bearings and therefore it is important to assess their influence in the initial spreading. The surface area of the film should be maximized with respect to the rotation rate, geometry and orientation of the tube, flow rate, wettability and contact line dynamics. Experiments are presented for a flat disk and a curved bowl, establishing the optimum height of release, rotation rate and tube orientation. Vibrations were imposed to investigate the changes in the film formation. We discuss the implications of our results in the VFD.

Estimating the hemodynamic impact of interventional treatments of aneurysms: numerical simulation with experimental validation: technical case report.

PubMed

Acevedo-Bolton, Gabriel; Jou, Liang-Der; Dispensa, Bradley P; Lawton, Michael T; Higashida, Randall T; Martin, Alastair J; Young, William L; Saloner, David

2006-08-01

The goal of this study was to use phase-contrast magnetic resonance imaging and computational fluid dynamics to estimate the hemodynamic outcome that might result from different interventional options for treating a patient with a giant fusiform aneurysm. We followed a group of patients with giant intracranial aneurysms who have no clear surgical options. One patient demonstrated dramatic aneurysm growth and was selected for further analysis. The aneurysm geometry and input and output flow conditions were measured with contrast-enhanced magnetic resonance angiography and phase-contrast magnetic resonance imaging. The data was imported into a computational fluid dynamics program and the velocity fields and wall shear stress distributions were calculated for the presenting physiological condition and for cases in which the opposing vertebral arteries were either occluded or opened. These models were validated with in vitro flow experiments using a geometrically exact silicone flow phantom. Simulation indicated that altering the flow ratio in the two vertebrals would deflect the main blood jet into the aneurysm belly, and that this would likely reduce the extent of the region of low wall shear stress in the growth zone. Computational fluid dynamics flow simulations in a complex patient-specific aneurysm geometry were validated by in vivo and in vitro phase-contrast magnetic resonance imaging, and were shown to be useful in modeling the likely hemodynamic impact of interventional treatment of the aneurysm.

Phoretic drag reduction of chemically active homogeneous spheres under force fields and shear flows

NASA Astrophysics Data System (ADS)

Yariv, Ehud; Kaynan, Uri

2017-01-01

Surrounded by a spherically symmetric solute cloud, chemically active homogeneous spheres do not undergo conventional autophoresis when suspended in an unbounded liquid domain. When exposed to external flows, solute advection deforms that cloud, resulting in a generally asymmetric distribution of diffusio-osmotic slip which, in turn, modifies particle motion. Inspired by classical forced-convection analyses [Acrivos and Taylor, Phys. Fluids 5, 387 (1962), 10.1063/1.1706630; Frankel and Acrivos, Phys. Fluids 11, 1913 (1968), 10.1063/1.1692218] we illustrate this phoretic phenomenon using two prototypic configurations, one where the particle sediments under a uniform force field and one where it is subject to a simple shear flow. In addition to the Péclet number Pe associated with the imposed flow, the governing nonlinear problem also depends upon α , the intrinsic Péclet number associated with the chemical activity of the particle. As in the forced-convection problems, the small-Péclet-number limit is nonuniform, breaking down at large distances away from the particle. Calculation of the leading-order autophoretic effects thus requires use of matched asymptotic expansions, the outer region being at distances that scale inversely with Pe and Pe1 /2 in the respective sedimentation and shear problems. In the sedimentation problem we find an effective drag reduction of fractional amount α /8 ; in the shear problem we find that the magnitude of the stresslet is decreased by a fractional amount α /4 . For a dilute particle suspension the latter result is manifested by a reduction of the effective viscosity.

Orbitally shaken shallow fluid layers. II. An improved wall shear stress model

NASA Astrophysics Data System (ADS)

Alpresa, Paola; Sherwin, Spencer; Weinberg, Peter; van Reeuwijk, Maarten

2018-03-01

A new model for the analytical prediction of wall shear stress distributions at the base of orbitally shaken shallow fluid layers is developed. This model is a generalisation of the classical extended Stokes solution and will be referred to as the potential theory-Stokes model. The model is validated using a large set of numerical simulations covering a wide range of flow regimes representative of those used in laboratory experiments. It is demonstrated that the model is in much better agreement with the simulation data than the classical Stokes solution, improving the prediction in 63% of the studied cases. The central assumption of the model—which is to link the wall shear stress with the surface velocity—is shown to hold remarkably well over all regimes covered.

Hair bundles of cochlear outer hair cells are shaped to minimize their fluid-dynamic resistance.

PubMed

Ciganović, Nikola; Wolde-Kidan, Amanuel; Reichenbach, Tobias

2017-06-15

The mammalian sense of hearing relies on two types of sensory cells: inner hair cells transmit the auditory stimulus to the brain, while outer hair cells mechanically modulate the stimulus through active feedback. Stimulation of a hair cell is mediated by displacements of its mechanosensitive hair bundle which protrudes from the apical surface of the cell into a narrow fluid-filled space between reticular lamina and tectorial membrane. While hair bundles of inner hair cells are of linear shape, those of outer hair cells exhibit a distinctive V-shape. The biophysical rationale behind this morphology, however, remains unknown. Here we use analytical and computational methods to study the fluid flow across rows of differently shaped hair bundles. We find that rows of V-shaped hair bundles have a considerably reduced resistance to crossflow, and that the biologically observed shapes of hair bundles of outer hair cells are near-optimal in this regard. This observation accords with the function of outer hair cells and lends support to the recent hypothesis that inner hair cells are stimulated by a net flow, in addition to the well-established shear flow that arises from shearing between the reticular lamina and the tectorial membrane.

Modeling and design of optimal flow perfusion bioreactors for tissue engineering applications.

PubMed

Hidalgo-Bastida, L Araida; Thirunavukkarasu, Sundaramoorthy; Griffiths, Sarah; Cartmell, Sarah H; Naire, Shailesh

2012-04-01

Perfusion bioreactors have been used in different tissue engineering applications because of their consistent distribution of nutrients and flow-induced shear stress within the tissue-engineering scaffold. A widely used configuration uses a scaffold with a circular cross-section enclosed within a cylindrical chamber and inlet and outlet pipes which are connected to the chamber on either side through which media is continuously circulated. However, fluid-flow experiments and simulations have shown that the majority of the flow perfuses through the center. This pattern creates stagnant zones in the peripheral regions as well as in those of high flow rate near the inlet and outlet. This non-uniformity of flow and shear stress, owing to a circular design, results in limited cell proliferation and differentiation in these areas. The focus of this communication is to design an optimized perfusion system using computational fluid dynamics as a mathematical tool to overcome the time-consuming trial and error experimental method. We compared the flow within a circular and a rectangular bioreactor system. Flow simulations within the rectangular bioreactor are shown to overcome the limitations in the circular design. This communication challenges the circular cross-section bioreactor configuration paradigm and provides proof of the advantages of the new design over the existing one. Copyright © 2011 Wiley Periodicals, Inc.

Fluid shear stress stimulates prostaglandin and nitric oxide release in bone marrow-derived preosteoclast-like cells

NASA Technical Reports Server (NTRS)

McAllister, T. N.; Du, T.; Frangos, J. A.

2000-01-01

Bone is a porous tissue that is continuously perfused by interstitial fluid. Fluid flow, driven by both vascular pressure and mechanical loading, may generate significant shear stresses through the canaliculi as well as along the bone lining at the endosteal surface. Both osteoblasts and osteocytes produce signaling factors such as prostaglandins and nitric in response to fluid shear stress (FSS); however, these humoral agents appear to have more profound affects on osteoclast activity at the endosteal surface. We hypothesized that osteoclasts and preosteoclasts may also be mechanosensitive and that osteoclast-mediated autocrine signaling may be important in bone remodeling. In this study, we investigated the effect of FSS on nitric oxide (NO), prostaglandin E(2) (PGE(2)), and prostacyclin (PGI(2)) release by neonatal rat bone marrow-derived preosteoclast-like cells. These cells were tartrate-resistant acid phosphatase (TRAP) positive, weakly nonspecific esterase (NSE) positive, and capable of fusing into calcitonin-responsive, bone-resorbing, multinucleated cells. Bone marrow-derived preosteoclast-like cells exposed for 6 h to a well-defined FSS of 16 dynes/cm(2) produced NO at a rate of 7.5 nmol/mg protein/h, which was 10-fold that of static controls. This response was completely abolished by 100 microM N(G)-amino-L-arginine (L-NAA). Flow also stimulated PGE(2) production (3.9 microg/mg protein/h) and PGI(2) production (220 pg/mg protein/h). L-NAA attenuated flow-induced PGE(2) production by 30%, suggesting that NO may partially modulate PGE(2) production. This is the first report demonstrating that marrow derived cells are sensitive to FSS and that autocrine signaling in these cells may play an important role in load-induced remodeling and signal transduction in bone. Copyright 2000 Academic Press.

A three-dimensional computational fluid dynamics model of shear stress distribution during neotissue growth in a perfusion bioreactor.

PubMed

Guyot, Y; Luyten, F P; Schrooten, J; Papantoniou, I; Geris, L

2015-12-01

Bone tissue engineering strategies use flow through perfusion bioreactors to apply mechanical stimuli to cells seeded on porous scaffolds. Cells grow on the scaffold surface but also by bridging the scaffold pores leading a fully filled scaffold following the scaffold's geometric characteristics. Current computational fluid dynamic approaches for tissue engineering bioreactor systems have been mostly carried out for empty scaffolds. The effect of 3D cell growth and extracellular matrix formation (termed in this study as neotissue growth), on its surrounding fluid flow field is a challenge yet to be tackled. In this work a combined approach was followed linking curvature driven cell growth to fluid dynamics modeling. The level-set method (LSM) was employed to capture neotissue growth driven by curvature, while the Stokes and Darcy equations, combined in the Brinkman equation, provided information regarding the distribution of the shear stress profile at the neotissue/medium interface and within the neotissue itself during growth. The neotissue was assumed to be micro-porous allowing flow through its structure while at the same time allowing the simulation of complete scaffold filling without numerical convergence issues. The results show a significant difference in the amplitude of shear stress for cells located within the micro-porous neo-tissue or at the neotissue/medium interface, demonstrating the importance of taking along the neotissue in the calculation of the mechanical stimulation of cells during culture.The presented computational framework is used on different scaffold pore geometries demonstrating its potential to be used a design as tool for scaffold architecture taking into account the growing neotissue. Biotechnol. Bioeng. 2015;112: 2591-2600. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.

Fourier-domain study of drift turbulence driven sheared flow in a laboratory plasma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xu, M.; Tynan, G. R.; Holland, C.

2010-03-15

Frequency-resolved nonlinear internal and kinetic energy transfer rates have been measured in the Controlled Shear Decorrelation Experiment (CSDX) linear plasma device using a recently developed technique [Xu et al., Phys. Plasmas 16, 042312 (2009)]. The results clearly show a net kinetic energy transfer into the zonal flow frequency region, consistent with previous time-domain observations of turbulence-driven shear flows [Tynan et al., Plasma Phys. Controlled Fusion 48, S51 (2006)]. The experimentally measured dispersion relation has been used to map the frequency-resolved energy transfer rates into the wave number domain, which shows that the shear flow drive comes from midrange (k{sub t}hetarho{submore » S}>0.3) drift fluctuations, and the strongest flow drive comes from k{sub t}hetarho{sub S}approx =1 fluctuations. Linear growth rates have been inferred from a linearized Hasegawa-Wakatani model [Hasegawa et al., Phys. Fluids 22, 2122 (1979)], which indicates that the m=0 mode is linearly stable and the m=1-10 modes (corresponding to k{sub t}hetarho{sub S}>0.3) are linearly unstable for the n=1 and n=2 radial eigenmodes. This is consistent with our energy transfer measurements.« less

Flow Induced by Ex-Vivo Nasal Cilia: Developing an Index of Dyskinesis

NASA Astrophysics Data System (ADS)

Grotberg, James; Bottier, Mathieu; Pena-Fernandez, Marta; Blanchon, Sylvain; Pelle, Gabriel; Bequignon, Emilie; Isabey, Daniel; Coste, Andre; Escudier, Estelle; Papon, Jean-Francois; Filoche, Marcel; Louis, Bruno

2017-11-01

Mucociliary clearance is one of the major lines of defense of the respiratory system. The mucus layer coating the pulmonary airways is moved along and out of the lung by the activity of motile cilia, thus expelling the particles trapped in it. Here we compare ex vivomeasurements of a Newtonian flow induced by cilia beating (using micro-beads as tracers) and a mathematical model of this fluid flow. Samples of nasal epithelial cells placed in water are recorded by high-speed video-microscopy and ciliary beat pattern is inferred. Automatic tracking of micro-beads, used as markers of the flow generated by cilia motion, enables us also to assess the steady velocity profile as a function of the distance above the cilia. This profile is shown to be essentially parabolic. This compares well to a 2D mathematical model for ciliary fluid propulsion using an envelope model. From the model and the experimental measurements, the shear stress exerted by the cilia is deduced. Finally, this shear stress is proposed as a new index for characterizing the efficiency of ciliary beating and diagnosing dyskinesis.

Motion of particles with inertia in a compressible free shear layer

NASA Technical Reports Server (NTRS)

Samimy, M.; Lele, S. K.

1991-01-01

The effects of the inertia of a particle on its flow-tracking accuracy and particle dispersion are studied using direct numerical simulations of 2D compressible free shear layers in convective Mach number (Mc) range of 0.2 to 0.6. The results show that particle response is well characterized by tau, the ratio of particle response time to the flow time scales (Stokes' number). The slip between particle and fluid imposes a fundamental limit on the accuracy of optical measurements such as LDV and PIV. The error is found to grow like tau up to tau = 1 and taper off at higher tau. For tau = 0.2 the error is about 2 percent. In the flow visualizations based on Mie scattering, particles with tau more than 0.05 are found to grossly misrepresent the flow features. These errors are quantified by calculating the dispersion of particles relative to the fluid. Overall, the effect of compressibility does not seem to be significant on the motion of particles in the range of Mc considered here.

The influence of slip velocity and temperature on permeability during and after high-velocity fault slip

NASA Astrophysics Data System (ADS)

Tanikawa, W.; Mukoyoshi, H.; Tadai, O.; Hirose, T.; Lin, W.

2011-12-01

Fluid transport properties in fault zones play an important role in dynamic processes during large earthquakes. If the permeability in a fault zone is low, high pore-fluid pressures caused by thermal pressurization (Sibson, 1973) or shear-induced compaction (Blanpied et al., 1992) can lead to an apparent reduction of fault strength. Changes in porosity and permeability of fault rocks within a fault zone during earthquakes and the subsequent progressive recovery of these properties may have a large influence on earthquake recurrence (Sleep and Blanpied, 1992). A rotary shear apparatus was used to investigate changes of fluid transport properties in a fault zone by real-time measurement of gas flow rates during and after shearing of hollow sandstone and granite cylinders at various slip rates. Our apparatus measures permeability parallel to the slip plane in both the slip zone and wall rocks. In all cases, permeability decreased rapidly with an increase of friction, but recovered soon after slip, reaching a steady state within several tens of minutes. The rate of reduction of permeability increased with increasing slip velocity. Permeability did not recover to pre-slip levels after low-velocity tests but recovered to exceed them after high-velocity tests. Frictional heating of gases at the slip surface increased gas viscosity, which increased gas flow rate to produce an apparent permeability increase. The irreversible permeability changes of the low-velocity tests were caused by gouge formation due to wearing and smoothing of the slip surface. The increase of permeability after high-velocity tests was caused by mesoscale fracturing in response to rapid temperature rise. Changes of pore fluid viscosity contributed more to changes of flow rate than did permeability changes caused by shear deformation, although test results from different rocks and pore fluids might be different. References Blanpied, M.L., Lockner, D.A., Byerlee, J.D., 1992. An earthquake mechanism based on rapid sealing of faults. Nature 358, 574-576 Sibson, R.H., 1973. Interactions between temperature and pore fluid pressure during earthquake faulting: A mechanism for partial or total stress relief. Nature 243, 66-68. Sleep, N.H., Blanpied, M.L., 1992. Creep, compaction and the weak rheology of major faults. Nature 359, 687-692.

Mathematical modeling of power law and Herschel - Buckley non-Newtonian fluid of blood flow through a stenosed artery with permeable wall: Effects of slip velocity

NASA Astrophysics Data System (ADS)

Chitra, M.; Karthikeyan, D.

2018-04-01

A mathematical model of non-Newtonian blood flow through a stenosed artery is considered. The steadynon-Newtonian model is chosen characterized by the generalized power-law model and Herschel-Bulkley model incorporating the effect of slip velocity due to steanosed artery with permeable wall. The effects of slip velocity for non-Newtonian nature of blood on velocity, flow rate and wall shear stress of the stenosed artery with permeable wall are solved analytically. The effects of various parameters such as slip parameter (λ), power index (m) and different thickness of the stenosis (δ) on velocity, volumetric flow rate and wall shear stress are discussed through graphs.

Micro-scale dynamic simulation of erythrocyte-platelet interaction in blood flow.

PubMed

AlMomani, T; Udaykumar, H S; Marshall, J S; Chandran, K B

2008-06-01

Platelet activation, adhesion, and aggregation on the blood vessel and implants result in the formation of mural thrombi. Platelet dynamics in blood flow is influenced by the far more numerous erythrocytes (RBCs). This is particularly the case in the smaller blood vessels (arterioles) and in constricted regions of blood flow (such as in valve leakage and hinge regions) where the dimensions of formed elements of blood become comparable with that of the flow geometry. In such regions, models to predict platelet motion, activation, aggregation and adhesion must account for platelet-RBC interactions. This paper studies platelet-RBC interactions in shear flows by performing simulations of micro-scale dynamics using a computational fluid dynamics (CFD) model. A level-set sharp-interface immersed boundary method is employed in the computations in which RBC and platelet boundaries are tracked on a two-dimensional Cartesian grid. The RBCs are assumed to have an elliptical shape and to deform elastically under fluid forces while the platelets are assumed to behave as rigid particles of circular shape. Forces and torques between colliding blood cells are modeled using an extension of the soft-sphere model for elliptical particles. RBCs and platelets are transported under the forces and torques induced by fluid flow and cell-cell and cell-platelet collisions. The simulations show that platelet migration toward the wall is enhanced with increasing hematocrit, in agreement with past experimental observations. This margination is seen to occur due to hydrodynamic forces rather than collisional forces or volumetric exclusion effects. The effect of fluid shear forces on the platelets increases exponentially as a function of hematocrit for the range of parameters covered in this study. The micro-scale analysis can be potentially employed to obtain a deterministic relationship between fluid forces and platelet activation and aggregation in blood flow past cardiovascular implants.

Effects of density gradient caused by multi-pulsing CHI on two-fluid flowing equilibria of spherical torus plasmas

NASA Astrophysics Data System (ADS)

Kanki, T.; Nagata, M.

2014-10-01

Two-fluid dynamo relaxation is examined to understand sustainment mechanism of spherical torus (ST) plasmas by multi-pulsing CHI (M-CHI) in the HIST device. The steeper density gradient between the central open flux column (OFC) and closed flux regions by applying the second CHI pulse is observed to cause not only the E × B drift but also the ion diamagnetic drift, leading the two-fluid dynamo. The purpose of this study is to investigate the effects of the steep change in the density gradient on the ST equilibria by using the two-fluid equilibrium calculations. The toroidal magnetic field becomes from a diamagnetic to a paramagnetic profile in the closed flux region while it remains a diamagnetic profile in the OFC region. The toroidal ion flow velocity is increased from negative to positive values in the closed flux region. Here, the negative ion flow velocity is the opposite direction to the toroidal current. The poloidal ion flow velocity between the OFC and closed flux regions is increased, because the ion diamagnetic drift velocity is changed in the same direction as the E × B drift velocity through the steeper ion pressure gradient. As a result, the strong shear flow and the paramagnetic toroidal field are generated in the closed flux region. Here, the ion flow velocity is the same direction as the poloidal current. The radial electric field shear between the OFC and closed flux regions is enhanced due to the strong dependence on the magnetic force through the interaction of toroidal ion flow velocity and axial magnetic field. The two-fluid effect is significant there due to the ion diamagnetic effect.

A numerical model of a red blood cell infected by Plasmodium falciparum malaria: coupling cell mechanics with ligand-receptor interactions

NASA Astrophysics Data System (ADS)

Ishida, Shunichi; Imai, Yohsuke; Ichikawa, Yuki; Nix, Stephanie; Matsunaga, Daiki; Omori, Toshihiro; Ishikawa, Takuji

2016-01-01

We developed a numerical model of the behavior of a red blood cell infected by Plasmodium falciparum malaria on a wall in shear flow. The fluid and solid mechanics of an infected red blood cell (Pf-IRBC) were coupled with the biochemical interaction of ligand-receptor bindings. We used the boundary element method for fluid mechanics, the finite element method for membrane mechanics, and the Monte Carlo method for ligand-receptor interactions. We simulated the behavior of a Pf-IRBC in shear flow, focusing on the effects of bond type. For slip bonds, the Pf-IRBC exhibited firm adhesion, tumbling motion, and tank-treading motion, depending on the applied shear rate. The behavior of catch bonds resembled that of slip bonds, except for a 'catch' state at high shear stress. When the reactive compliance decreased to a value in the order of ? nm, both the slip and catch bonds behaved like an ideal bond. Such bonds do not respond to the force applied to the bond, and the velocity is stabilized at a high shear rate. Finally, we compared the numerical results with previous experiments for A4- and ItG-infected cells. We found that the interaction between PfEMP1 and ICAM-1 could be a nearly ideal bond, with a dissociation rate ranging from ? to ?.

Equilibrium states of homogeneous sheared compressible turbulence

NASA Astrophysics Data System (ADS)

Riahi, M.; Lili, T.

2011-06-01

Equilibrium states of homogeneous compressible turbulence subjected to rapid shear is studied using rapid distortion theory (RDT). The purpose of this study is to determine the numerical solutions of unsteady linearized equations governing double correlations spectra evolution. In this work, RDT code developed by authors solves these equations for compressible homogeneous shear flows. Numerical integration of these equations is carried out using a second-order simple and accurate scheme. The two Mach numbers relevant to homogeneous shear flow are the turbulent Mach number Mt, given by the root mean square turbulent velocity fluctuations divided by the speed of sound, and the gradient Mach number Mg which is the mean shear rate times the transverse integral scale of the turbulence divided by the speed of sound. Validation of this code is performed by comparing RDT results with direct numerical simulation (DNS) of [A. Simone, G.N. Coleman, and C. Cambon, Fluid Mech. 330, 307 (1997)] and [S. Sarkar, J. Fluid Mech. 282, 163 (1995)] for various values of initial gradient Mach number Mg0. It was found that RDT is valid for small values of the non-dimensional times St (St < 3.5). It is important to note that RDT is also valid for large values of St (St > 10) in particular for large values of Mg0. This essential feature justifies the resort to RDT in order to determine equilibrium states in the compressible regime.

Normal stress differences and beyond-Navier-Stokes hydrodynamics

NASA Astrophysics Data System (ADS)

Alam, Meheboob; Saha, Saikat

2017-06-01

A recently proposed beyond-Navier-Stokes order hydrodynamic theory for dry granular fluids is revisited by focussing on the behaviour of the stress tensor and the scaling of related transport coefficients in the dense limit. For the homogeneous shear flow, it is shown that the eigen-directions of the second-moment tensor and those of the shear tensor become co-axial, thus making the first normal stress difference (N1) to zero in the same limit. In contrast, the origin of the second normal stress difference (N2) is tied to the `excess' temperature along the mean-vorticity direction and the imposed shear field, respectively, in the dilute and dense flows. The scaling relations for transport coefficients are suggested based on the present theory.

Limitations of the clump-correlation theories of shear-induced turbulence suppression

NASA Astrophysics Data System (ADS)

Zhang, Y. Z.; Mahajan, S. M.

2017-05-01

The clump theory, primarily constructed by Dupree [Phys. Fluids 15, 334 (1972)] based on the moment approach and then generalized to the correlation theory [Y. Z. Zhang and S. M. Mahajan, Phys. Fluids B 5, 2000 (1993)], has long served as a basis for constructing theories of turbulence suppression by shear flow. In order to reveal the "intrinsic approximation" invoked in the clump-correlation theory, we examine a model based on two dimensional magnetized drift waves. After a rigorous derivation of the exact response function—a key to average the Green function of the system—we show that the Dupree, Zhang-Mahajan approach is recovered as the lowest order approximation in a small dimensionless parameter ϒ which is a triple product of the correlation time, wave number, and fluctuating drift velocity. The clump-correlation theory, thus, constitutes the Gaussian and lowest order non-Markovian process for a homogeneous stationary turbulence. We also provide, especially for the tokamak community, a readily usable formula to evaluate the effectiveness of shear-flow suppression; this formula pertains regardless of the specific model of correlation time.

Normal stress differences from Oldroyd 8-constant framework: Exact analytical solution for large-amplitude oscillatory shear flow

NASA Astrophysics Data System (ADS)

Saengow, C.; Giacomin, A. J.

2017-12-01

The Oldroyd 8-constant framework for continuum constitutive theory contains a rich diversity of popular special cases for polymeric liquids. In this paper, we use part of our exact solution for shear stress to arrive at unique exact analytical solutions for the normal stress difference responses to large-amplitude oscillatory shear (LAOS) flow. The nonlinearity of the polymeric liquids, triggered by LAOS, causes these responses at even multiples of the test frequency. We call responses at a frequency higher than twice the test frequency higher harmonics. We find the new exact analytical solutions to be compact and intrinsically beautiful. These solutions reduce to those of our previous work on the special case of the corotational Maxwell fluid. Our solutions also agree with our new truncated Goddard integral expansion for the special case of the corotational Jeffreys fluid. The limiting behaviors of these exact solutions also yield new explicit expressions. Finally, we use our exact solutions to see how η∞ affects the normal stress differences in LAOS.

Flow-induced protein kinase A–CREB pathway acts via BMP signaling to promote HSC emergence

PubMed Central

Kim, Peter Geon; Nakano, Haruko; Das, Partha P.; Chen, Michael J.; Rowe, R. Grant; Chou, Stephanie S.; Ross, Samantha J.; Sakamoto, Kathleen M.; Zon, Leonard I.; Schlaeger, Thorsten M.; Orkin, Stuart H.; Nakano, Atsushi

2015-01-01

Fluid shear stress promotes the emergence of hematopoietic stem cells (HSCs) in the aorta–gonad–mesonephros (AGM) of the developing mouse embryo. We determined that the AGM is enriched for expression of targets of protein kinase A (PKA)–cAMP response element-binding protein (CREB), a pathway activated by fluid shear stress. By analyzing CREB genomic occupancy from chromatin-immunoprecipitation sequencing (ChIP-seq) data, we identified the bone morphogenetic protein (BMP) pathway as a potential regulator of CREB. By chemical modulation of the PKA–CREB and BMP pathways in isolated AGM VE-cadherin+ cells from mid-gestation embryos, we demonstrate that PKA–CREB regulates hematopoietic engraftment and clonogenicity of hematopoietic progenitors, and is dependent on secreted BMP ligands through the type I BMP receptor. Finally, we observed blunting of this signaling axis using Ncx1-null embryos, which lack a heartbeat and intravascular flow. Collectively, we have identified a novel PKA–CREB–BMP signaling pathway downstream of shear stress that regulates HSC emergence in the AGM via the endothelial-to-hematopoietic transition. PMID:25870201

High-Energy-Density Shear Flow and Instability Experiments

NASA Astrophysics Data System (ADS)

Doss, F. W.; Flippo, K. A.; Merritt, E. C.; di Stefano, C. A.; Devolder, B. G.; Kurien, S.; Kline, J. L.

2017-10-01

High-energy-density shear experiments have been performed by LANL at the OMEGA Laser Facility and National Ignition Facility (NIF). The experiments have been simulated using the LANL radiation-hydrocode RAGE and have been used to assess turbulence models ability to function in the high-energy-density, inertial- fusion-relevant regime. Beginning with the basic configuration of two counter-oriented shock-driven flows of >= 100 km/s, which initiate a strong shear instability across an initially solid-density, 20 μm thick Al plate, variations of the experiment to details of the initial conditions have been performed. These variations have included increasing the fluid densities (by modifying the plate material from Al to Ti and Cu), imposing sinusoidal seed perturbations on the plate, and directly modifying the plate's intrinsic surface roughness. Radiography of the unseeded layer has revealed the presence of emergent Kelvin-Helmholtz structures which may be analyzed to infer fluid-mechanical properties including turbulent energy density. This work is conducted by the US DOE by LANL under contract DE-0AC52-06NA25396. This abstract is LA-UR-16-24930.

Variation in bed level shear stress on surfaces sheltered by nonerodible roughness elements

NASA Astrophysics Data System (ADS)

Sutton, Stephen L. F.; McKenna-Neuman, Cheryl

2008-09-01

Direct bed level observations of surface shear stress, pressure gradient variability, turbulence intensity, and fluid flow patterns were carried out in the vicinity of cylindrical roughness elements mounted in a boundary layer wind tunnel. Paired corkscrew vortices shed from each of the elements result in elevated shear stress and increased potential for the initiation of particle transport within the far wake. While the size and shape of these trailing vortices change with the element spacing, they persist even for large roughness densities. Wake interference coincides with the impingement of the upwind horseshoe vortices upon one another at a point when their diameter approaches half the distance between the roughness elements. While the erosive capability of the horseshoe vortex has been suggested for a variety of settings, the present study shows that the fluid stress immediately beneath this coherent structure is actually small in comparison to that caused by compression of the incident flow as it is deflected around the element and attached vortex. Observations such as these are required for further refinement of models of stress partitioning on rough surfaces.

Endothelial atheroprotective and anti-inflammatory mechanisms.

PubMed

Berk, B C; Abe, J I; Min, W; Surapisitchat, J; Yan, C

2001-12-01

Atherosclerosis preferentially occurs in areas of turbulent flow and low fluid shear stress, whereas laminar flow and high shear stress are atheroprotective. Inflammatory cytokines, such as tumor necrosis factor-alpha (TNF), have been shown to stimulate expression of endothelial cell (EC) genes that may promote atherosclerosis. Recent data suggest that steady laminar flow decreases EC apoptosis and blocks TNF-mediated EC activation. EC apoptosis is likely important in the process termed "plaque erosion" that leads to platelet aggregation. Steady laminar flow inhibits EC apoptosis by preventing cell cycle entry, by increasing antioxidant mechanisms (e.g., superoxide dismutase), and by stimulating nitric oxide-dependent protective pathways that involve enzymes PI3-kinase and Akt. Conversely, our laboratory has identified nitric oxide-independent mechanisms that limit TNF signal transduction. TNF regulates gene expression in EC, in part, by stimulating mitogen-activated protein kinases (MAPK) which phosphorylate transcription factors. We hypothesized that fluid shear stress modulates TNF effects on EC by inhibiting TNF-mediated activation of MAP kinases. To test this hypothesis, we determined the effects of steady laminar flow (shear stress = 12 dynes/cm2) on TNF-stimulated activity of two MAP kinases: extracellular signal regulated kinase (ERK1/2) and c-Jun N-terminal kinase (JNK). Flow alone stimulated ERK1/2 activity, but decreased JNK activity compared to static controls. TNF (10 ng/ml) alone activated both ERK1/2 and JNK maximally at 15 minutes in human umbilical vein EC (HUVEC). Pre-exposing HUVEC for 10 minutes to flow inhibited TNF activation of JNK by 46%, but it had no significant effect on ERK1/2 activation. Incubation of EC with PD98059, a specific mitogen-activated protein kinase kinase inhibitor, blocked the flow-mediated inhibition of TNF activation of JNK. Flow-mediated inhibition of JNK was unaffected by 0.1 mM L-nitroarginine, 100 pM 8-bromo-cyclic GMP, or 100 microM 8-bromo-cyclic AMP. Transfection studies with dominant negative constructs of the protein kinase MEK1 and MEK5 suggested an important role for BMK1 in flow-mediated regulation of TNF signals. In summary, the atheroprotective effects of steady laminar flow on the endothelium involve multiple synergistic mechanisms.

Nonlinear flow response of soft hair beds

NASA Astrophysics Data System (ADS)

Alvarado, José; Comtet, Jean; de Langre, Emmanuel; Hosoi, A. E.

2017-10-01

We are `hairy' on the inside: beds of passive fibres anchored to a surface and immersed in fluids are prevalent in many biological systems, including intestines, tongues, and blood vessels. These hairs are soft enough to deform in response to stresses from fluid flows. Yet fluid stresses are in turn affected by hair deformation, leading to a coupled elastoviscous problem that is poorly understood. Here we investigate a biomimetic model system of elastomer hair beds subject to shear-driven Stokes flows. We characterize this system with a theoretical model that accounts for the large-deformation flow response of hair beds. Hair bending results in a drag-reducing nonlinearity because the hair tip lowers towards the base, widening the gap through which fluid flows. When hairs are cantilevered at an angle subnormal to the surface, flow against the grain bends hairs away from the base, narrowing the gap. The flow response of angled hair beds is axially asymmetric and amounts to a rectification nonlinearity. We identify an elastoviscous parameter that controls nonlinear behaviour. Our study raises the hypothesis that biological hairy surfaces function to reduce fluid drag. Furthermore, angled hairs may be incorporated in the design of integrated microfluidic components, such as diodes and pumps.

Study of blood flow in several benchmark micro-channels using a two-fluid approach

PubMed Central

Wu, Wei-Tao; Yang, Fang; Antaki, James F.; Aubry, Nadine; Massoudi, Mehrdad

2015-01-01

It is known that in a vessel whose characteristic dimension (e.g., its diameter) is in the range of 20 to 500 microns, blood behaves as a non-Newtonian fluid, exhibiting complex phenomena, such as shear-thinning, stress relaxation, and also multi-component behaviors, such as the Fahraeus effect, plasma-skimming, etc. For describing these non-Newtonian and multi-component characteristics of blood, using the framework of mixture theory, a two-fluid model is applied, where the plasma is treated as a Newtonian fluid and the red blood cells (RBCs) are treated as shear-thinning fluid. A computational fluid dynamic (CFD) simulation incorporating the constitutive model was implemented using OpenFOAM® in which benchmark problems including a sudden expansion and various driven slots and crevices were studied numerically. The numerical results exhibited good agreement with the experimental observations with respect to both the velocity field and the volume fraction distribution of RBCs. PMID:26240438

Modeling flow for modified concentric cylinder rheometer geometry

NASA Astrophysics Data System (ADS)

Ekeruche, Karen; Connelly, Kelly; Kavehpour, H. Pirouz

2016-11-01

Rheology experiments on biological fluids can be difficult when samples are limited in volume, sensitive to degradation, and delicate to extract from tissues. A probe-like geometry has been developed to perform shear creep experiments on biological fluids and to use the creep response to characterize fluid material properties. This probe geometry is a modified concentric cylinder setup, where the gap is large and we assume the inner cylinder rotates in an infinite fluid. To validate this assumption we perform shear creep tests with the designed probe on Newtonian and non-Newtonian fluids and vary the outer cylinder container diameter. We have also created a numerical model based on the probe geometry setup to compare with experimental results at different outer cylinder diameters. A creep test is modeled by applying rotation to the inner cylinder and solving for the deformation of the fluid throughout the gap. Steady state viscosity values are calculated from creep compliance curves and compared between experimental and numerical results.

A study of unsteady physiological magneto-fluid flow and heat transfer through a finite length channel by peristaltic pumping.

PubMed

Tripathi, Dharmendra; Bég, O Anwar

2012-08-01

Magnetohydrodynamic peristaltic flows arise in controlled magnetic drug targeting, hybrid haemodynamic pumps and biomagnetic phenomena interacting with the human digestive system. Motivated by the objective of improving an understanding of the complex fluid dynamics in such flows, we consider in the present article the transient magneto-fluid flow and heat transfer through a finite length channel by peristaltic pumping. Reynolds number is small enough and the wavelength to diameter ratio is large enough to negate inertial effects. Analytical solutions for temperature field, axial velocity, transverse velocity, pressure gradient, local wall shear stress, volume flowrate and averaged volume flowrate are obtained. The effects of the transverse magnetic field, Grashof number and thermal conductivity on the flow patterns induced by peristaltic waves (sinusoidal propagation along the length of channel) are studied using graphical plots. The present study identifies that greater pressure is required to propel the magneto-fluid by peristaltic pumping in comparison to a non-conducting Newtonian fluid, whereas, a lower pressure is required if heat transfer is effective. The analytical solutions further provide an important benchmark for future numerical simulations.

Hydro-Mechanical Modelling of Slow Slip Phenomena at the Subduction Interface.

NASA Astrophysics Data System (ADS)

Petrini, C.; Gerya, T.; Madonna, C.; van Dinther, Y.

2016-12-01

Subduction zones experience a spectrum of slip phenomena, ranging from large devastating megathrust earthquakes to aseismic slow slip events. Slow slip events, lasting hours to years and being perceptible only by instruments, are believed to have the capability to induce large earthquakes. It is also repeatedly proposed that such slow events are controlled by fluid-rock interactions along the subduction interface, thus calling for development of fully coupled seismo-hydro-mechanical modeling approaches to identify their physics and controlling parameters. We present a newly developed finite difference visco-elasto-plastic numerical code with marker-in-cell technique, which fully couples mechanical deformation and fluid flow. We use this to investigate how the presence of fluids in the pore space of a (de)compacting rock matrix affects elastic stress accumulation and release along a fluid-bearing subduction interface. The model simulates the spontaneous occurrence of quasi-periodic slow slip phenomena along self-consistently forming highly localized shearbands, which accommodate shear displacement between two plates. The produced elastic rebound events show a slip velocity on the order of cm/yr, which is in good agreement with measured data. The governing gradual strength decrease along the slowly propagating shear bands is related to a drop in total pressure caused by shear localization at nearly constant (slightly decreasing) fluid pressure. Gradual reduction of the difference between the total and fluid pressure decreases brittle/plastic strength of fluid-bearing rocks along the shear bands, thus providing a dynamic feedback mechanism for the accumulated elastic stress release at the subduction interface.

Blood flow and coherent vortices in the normal and aneurysmatic aortas: a fluid dynamical approach to intra-luminal thrombus formation.

PubMed

Biasetti, Jacopo; Hussain, Fazle; Gasser, T Christian

2011-10-07

Abdominal aortic aneurysms (AAAs) are frequently characterized by the development of an intra-luminal thrombus (ILT), which is known to have multiple biochemical and biomechanical implications. Development of the ILT is not well understood, and shear-stress-triggered activation of platelets could be the first step in its evolution. Vortical structures (VSs) in the flow affect platelet dynamics, which motivated the present study of a possible correlation between VS and ILT formation in AAAs. VSs educed by the λ(2)-method using computational fluid dynamics simulations of the backward-facing step problem, normal aorta, fusiform AAA and saccular AAA were investigated. Patient-specific luminal geometries were reconstructed from computed tomography scans, and Newtonian and Carreau-Yasuda models were used to capture salient rheological features of blood flow. Particularly in complex flow domains, results depended on the constitutive model. VSs developed all along the normal aorta, showing that a clear correlation between VSs and high wall shear stress (WSS) existed, and that VSs started to break up during late systole. In contrast, in the fusiform AAA, large VSs developed at sites of tortuous geometry and high WSS, occupying the entire lumen, and lasting over the entire cardiac cycle. Downward motion of VSs in the AAA was in the range of a few centimetres per cardiac cycle, and with a VS burst at that location, the release (from VSs) of shear-stress-activated platelets and their deposition to the wall was within the lower part of the diseased artery, i.e. where the thickest ILT layer is typically observed. In the saccular AAA, only one VS was found near the healthy portion of the aorta, while in the aneurysmatic bulge, no VSs occurred. We present a fluid-dynamics-motivated mechanism for platelet activation, convection and deposition in AAAs that has the potential of improving our current understanding of the pathophysiology of fluid-driven ILT growth.

Transitional Benthic Boundary Layers and their Influence on Nutrient Flux in Tidal Estuaries

NASA Astrophysics Data System (ADS)

Koetje, K. M.; Foster, D. L.; Lippmann, T. C.; Kalnejais, L. H.

2016-12-01

Quantifying the coupled physical and geochemical processes in the fluid-sediment interface is critical to managing coastal resources. This is of particular importance during times of enhanced hydrodynamic forcing where extreme tide or wind events can have a significant impact on water quality. A combination of field and laboratory experiments were used to examine the relationship between large-scale fluid shear stresses and geochemical fluxes at the fluid-sediment interface in the Great Bay Estuary, New Hampshire. Sediment geochemical measurements paired with flow field observations along estuary-wide transects over several tidal cycles provide nutrient load estimates that can be scaled to represent the whole Bay. Three-dimensional flow field measurements collected using a maneuverable personal watercraft were used to determine the spatial and temporal variability of the shear stress throughout the Bay. High-resolution bottom boundary layer dynamics were observed using a suite of acoustic Doppler current profilers (ADCP) in order to improve the accuracy of diffusive flux estimates by directly measuring the thickness of the benthic boundary layer. Over the 2.5 m tidal range and at water depths ranging from 0.3 m to 1.5 m at mean lower low water, peak mean flows ranged from 0.2 m/s to 1 m/s at the sampling sites. The dominant contribution of hydrodynamic forcing to the Bay is due to tidal flows, which are largely unidirectional during flood tide. Sediment grain size analysis characterized the bed at sampling sites as fine-grained sandy mud (d50 = 47 μm). Sampling during typical tidal flow conditions, a smooth turbulent flow field was observed and the threshold of motion was not exceeded. Along with sediment characterization, porosity profiles and erosion chamber experiments were used to characterize nutrient release. This host of data provides shear stress estimates that can constrain nutrient loads under variable hydrodynamic conditions.

Substitute fluid examinations for liquid manure

NASA Astrophysics Data System (ADS)

Schrader, Kevin; Riedel, Marco; Eichert, Helmut

For the farming industry it is essential to use liquid manure as natural fertilizer. Through new agricultural regulation 2015 in Germany the industry must develop new liquid manure spreader systems because the ammonia and methane emission are limited. In a research project the University of Applied Sciences Zwickau and some other industry partners will develop such a new innovative liquid manure spreader. The new liquid manure spreader should use pulsating air to distribute the liquid manure exactly. The pulsating air, which flows through the pipelines, should be analysed at a test station. For examinations at this test station it is important to find another substitute fluid because liquid manure smells strong, is not transparent and is also not homogeneous enough for scientific investigations. Furthermore it is important to ensure that the substitute fluid is, like liquid manure, a non-Newtonian fluid. The substitute fluid must be a shear-thinning substance - this means the viscosity decrease at higher shear rate. Many different samples like soap-water-farragoes, jelly-water-farragoes, agar-water-farragoes, soap-ethanol-farragoes and more are, for the project, examined in regard of their physical properties to find the best substitute fluid. The samples are examined at the rotational viscometer for viscosity at various shear rates and then compared with the viscosity values of liquid manure.

Prediction of mass transfer coefficients in non-Newtonian fermentation media using first-principles methods.

PubMed

Radl, Stefan; Khinast, Johannes G

2007-08-01

Bubble flows in non-Newtonian fluids were analyzed using first-principles methods with the aim to compute and predict mass transfer coefficients in such fermentation media. The method we used is a Direct Numerical Simulation (DNS) of the reactive multiphase flow with deformable boundaries and interfaces. With this method, we are able for the first time to calculate mass transfer coefficients in non-Newtonian liquids of different rheologies without any experimental data. In the current article, shear-thinning fluids are considered. However, the results provide the basis for further investigations, such as the study of viscoelastic fluids. (c) 2007 Wiley Periodicals, Inc.

Computational fluid dynamics study of the end-side and sequential coronary artery bypass anastomoses in a native coronary occlusion model.

PubMed

Matsuura, Kaoru; Jin, Wei Wei; Liu, Hao; Matsumiya, Goro

2018-04-01

The objective of this study was to evaluate the haemodynamic patterns in each anastomosis fashion using a computational fluid dynamic study in a native coronary occlusion model. Fluid dynamic computations were carried out with ANSYS CFX (ANSYS Inc., Canonsburg, PA, USA) software. The incision lengths for parallel and diamond anastomoses were fixed at 2 mm. Native vessels were set to be totally occluded. The diameter of both the native and graft vessels was set to be 2 mm. The inlet boundary condition was set by a sample of the transient time flow measurement which was measured intraoperatively. The diamond anastomosis was observed to reduce flow to the native outlet and increase flow to the bypass outlet; the opposite was observed in the parallel anastomosis. Total energy efficiency was higher in the diamond anastomosis than the parallel anastomosis. Wall shear stress was higher in the diamond anastomosis than in the parallel anastomosis; it was the highest at the top of the outlet. A high oscillatory shear index was observed at the bypass inlet in the parallel anastomosis and at the native inlet in the diamond anastomosis. The diamond sequential anastomosis would be an effective option for multiple sequential bypasses because of the better flow to the bypass outlet than with the parallel anastomosis. However, flow competition should be kept in mind while using the diamond anastomosis for moderately stenotic vessels because of worsened flow to the native outlet. Care should be taken to ensure that the fluid dynamics patterns are optimal and prevent future native and bypass vessel disease progression.

2D instabilities of surface gravity waves on a linear shear current

NASA Astrophysics Data System (ADS)

Francius, Marc; Kharif, Christian

2016-04-01

Periodic 2D surface water waves propagating steadily on a rotational current have been studied by many authors (see [1] and references therein). Although the recent important theoretical developments have confirmed that periodic waves can exist over flows with arbitrary vorticity, their stability and their nonlinear evolution have not been much studied extensively so far. In fact, even in the rather simple case of uniform vorticity (linear shear), few papers have been published on the effect of a vertical shear current on the side-band instability of a uniform wave train over finite depth. In most of these studies [2-5], asymptotic expansions and multiple scales method have been used to obtain envelope evolution equations, which allow eventually to formulate a condition of (linear) instability to long modulational perturbations. It is noted here that this instability is often referred in the literature as the Benjamin-Feir or modulational instability. In the present study, we consider the linear stability of finite amplitude two-dimensional, periodic water waves propagating steadily on the free surface of a fluid with constant vorticity and finite depth. First, the steadily propagating surface waves are computed with steepness up to very close to the highest, using a Fourier series expansions and a collocation method, which constitutes a simple extension of Fenton's method [6] to the cases with a linear shear current. Then, the linear stability of these permanent waves to infinitesimal 2D perturbations is developed from the fully nonlinear equations in the framework of normal modes analysis. This linear stability analysis is an extension of [7] to the case of waves in the presence of a linear shear current and permits the determination of the dominant instability as a function of depth and vorticity for a given steepness. The numerical results are used to assess the accuracy of the vor-NLS equation derived in [5] for the characteristics of modulational instabilities due to resonant four-wave interactions, as well as to study the influence of vorticity and nonlinearity on the characteristics of linear instabilities due to resonant five-wave and six-wave interactions. Depending on the dimensionless depth, superharmonic instabilities due to five-wave interactions can become dominant with increasing positive vorticiy. Acknowledgments: This work was supported by the Direction Générale de l'Armement and funded by the ANR project n°. ANR-13-ASTR-0007. References [1] A. Constantin, Two-dimensionality of gravity water flows of constant non-zero vorticity beneath a surface wave train, Eur. J. Mech. B/Fluids, 2011, 30, 12-16. [2] R. S. Johnson, On the modulation of water waves on shear flows, Proc. Royal Soc. Lond. A., 1976, 347, 537-546. [3] M. Oikawa, K. Chow, D. J. Benney, The propagation of nonlinear wave packets in a shear flow with a free surface, Stud. Appl. Math., 1987, 76, 69-92. [4] A. I Baumstein, Modulation of gravity waves with shear in water, Stud. Appl. Math., 1998, 100, 365-90. [5] R. Thomas, C. Kharif, M. Manna, A nonlinear Schrödinger equation for water waves on finite depth with constant vorticity, Phys. Fluids, 2012, 24, 127102. [6] M. M Rienecker, J. D Fenton, A Fourier approximation method for steady water waves , J. Fluid Mech., 1981, 104, 119-137 [7] M. Francius, C. Kharif, Three-dimensional instabilities of periodic gravity waves in shallow water, J. Fluid Mech., 2006, 561, 417-437

A sliding plate microgap rheometer for the simultaneous measurement of shear stress and first normal stress difference

NASA Astrophysics Data System (ADS)

Baik, Seung Jae; Moldenaers, Paula; Clasen, Christian

2011-03-01

A new generation of the "flexure-based microgap rheometer" (the N-FMR) has been developed which is also capable of measuring, in addition to the shear stress, the first normal stress difference of micrometer thin fluid films. This microgap rheometer with a translation system based on compound spring flexures measures the rheological properties of microliter samples of complex fluids confined in a plane couette configuration with gap distances of h = 1-400 μm up to shear rates of dot γ = 3000 s-1. Feed back loop controlled precise positioning of the shearing surfaces with response times <1 ms enables to control the parallelism within 1.5 μrad and to maintain the gap distance within 20 nm. This precise gap control minimizes squeeze flow effects and allows therefore to measure the first normal stress difference N1 of the thin film down to a micrometer gap distance, with a lower limit of {{N_1 }/{dot γ }} = 9.375 × 10^{ - 11} {η/{h^2 }} that depends on the shear viscosity η and the squared inverse gap. Structural development of complex fluids in the confinement can be visualized by using a beam splitter on the shearing surface and a long working distance microscope. In summary, this new instrument allows to investigate the confinement dependent rheological and morphological evolution of micrometer thin films.

Visualization and Measurement of Flow in a Model Rotating-Wall Bioreactor

NASA Astrophysics Data System (ADS)

Brown, Jason B.; Neitzel, G. Paul

1997-11-01

Fluid shear has been observed to have an effect on the in vitro growth of mammalian cells and is expected to play a role in the in vitro development of aggregates of cells into tissue. The interactions between culture media and cell constructs within a circular Couette flow bioreactor with independently rotating cylinders are investigated in model studies using flow visualization. Particle-Image Velocimetry (PIV) is used to quantify the velocity field in a plane perpendicular to the vessel axis which contains a cell construct model. This velocity field is then used to compute the instantaneous shear field. Experiments show the path of the model cell construct is dependent on the rotation rates of the cylinders.

A numerical study of bifurcations in a barotropic shear flow

NASA Technical Reports Server (NTRS)

Huerre, P.; Keefe, L. R.; Meunier, G.; Redekopp, L. G.; Spalart, P. R.; Rogers, M. M.

1988-01-01

In the last few years, more and more evidence has emerged suggesting that transition to turbulence may be viewed as a succession of bifurcations to deterministic chaos. Most experimental and numerical observations have been restricted to Rayleigh-Benard convection and Taylor-Couette flow between concentric cylinders. An attempt is made to accurately describe the bifurcation sequence leading to chaos in a 2-D temporal free shear layer on the beta-plane. The beta-plane is a locally Cartesian reduction of the equations describing the dynamicss of a shallow layer of fluid on a rotating spherical planet. It is a valid model for large scale flows of interest in meteorology and oceanography.

The role of surface vorticity during unsteady separation

NASA Astrophysics Data System (ADS)

Melius, Matthew S.; Mulleners, Karen; Cal, Raúl Bayoán

2018-04-01

Unsteady flow separation in rotationally augmented flow fields plays a significant role in a variety of fundamental flows. Through the use of time-resolved particle image velocimetry, vorticity accumulation and vortex shedding during unsteady separation over a three-dimensional airfoil are examined. The results of the study describe the critical role of surface vorticity accumulation during unsteady separation and reattachment. Through evaluation of the unsteady characteristics of the shear layer, it is demonstrated that the buildup and shedding of surface vorticity directly influence the dynamic changes of the separation point location. The quantitative characterization of surface vorticity and shear layer stability enables improved aerodynamic designs and has a broad impact within the field of unsteady fluid dynamics.

Hydraulic properties of 3D rough-walled fractures during shearing: An experimental study

NASA Astrophysics Data System (ADS)

Yin, Qian; Ma, Guowei; Jing, Hongwen; Wang, Huidong; Su, Haijian; Wang, Yingchao; Liu, Richeng

2017-12-01

This study experimentally analyzed the influence of shear processes on nonlinear flow behavior through 3D rough-walled rock fractures. A high-precision apparatus was developed to perform stress-dependent fluid flow tests of fractured rocks. Then, water flow tests on rough-walled fractures with different mechanical displacements were conducted. At each shear level, the hydraulic pressure ranged from 0 to 0.6 MPa, and the normal load varied from 7 to 35 kN. The results show that (i) the relationship between the volumetric flow rate and hydraulic gradient of rough-walled fractures can be well fit using Forchheimer's law. Notably, both the linear and nonlinear coefficients in Forchheimer's law decrease during shearing; (ii) a sixth-order polynomial function is used to evaluate the transmissivity based on the Reynolds number of fractures during shearing. The transmissivity exhibits a decreasing trend as the Reynolds number increases and an increasing trend as the shear displacement increases; (iii) the critical hydraulic gradient, critical Reynolds number and equivalent hydraulic aperture of the rock fractures all increase as the shear displacement increases. When the shear displacement varies from 0 to 15 mm, the critical hydraulic gradient ranges from 0.3 to 2.2 for a normal load of 7 kN and increases to 1.8-8.6 for a normal load of 35 kN; and (iv) the Forchheimer law results are evaluated by plotting the normalized transmissivity of the fractures during shearing against the Reynolds number. An increase in the normal load shifts the fitted curves downward. Additionally, the Forchheimer coefficient β decreases with the shear displacement but increases with the applied normal load.

Unsteady sedimentation of a sphere in wormlike micellar fluids

NASA Astrophysics Data System (ADS)

Zhang, Yiran; Muller, Susan J.

2018-04-01

The unsteady sedimentation of a sphere in wormlike micellar fluids is studied experimentally through shear and extensional rheometry, sphere trajectory tracking, and particle image velocimetry. Unsteady sphere sedimentation characterized by fluctuations in the sphere settling velocity was observed for a range of sphere size and density in two non-shear-banding wormlike micellar solutions, a cetylpyridinium chloride (CpCl)-sodium salicylate (NaSal) solution and a cetyltrimethylammonium p-toluenesulfonate (CTAT)-NaCl solution. The onset of the transition from steady to unsteady sphere motion is characterized by an extensional Deborah number, D eext , defined locally in the negative wake of the falling sphere. This instability criterion is in agreement with previous findings by Mohammadigoushki and Muller [J. Rheol. 60, 587 (2016), 10.1122/1.4948800] in the wormlike micelle system of cetyltrimethylammonium bromide (CTAB) and NaSal, and appears to be universally valid independent of micelle chemistry or solution rheology (e.g., shear banding or not). Moreover, the frequency at which the sphere velocity fluctuates is found to be linearly correlated with an average shear Deborah number D es , which is a measure of the overall flow strength. This suggests that a constant critical strain is accumulated before the flow instability takes place in each velocity oscillation. The velocity fluctuations are found to become increasingly disordered with increasing elastic Mach number, M ae , indicating that the interactions between the flow instability and elastic wave propagation result in more chaotic velocity fluctuations.

Analogy between fluid cavitation and fracture mechanics

NASA Astrophysics Data System (ADS)

Hendricks, R. C.; Mullen, R. L.; Braun, M. J.

When the stresses imposed on a fluid are sufficiently large, rupture or cavitation can occur. Such conditions can exist in many two-phase flow applications, such as the choked flows, which can occur in seals and bearings. Nonspherical bubbles with large aspect ratios have been observed in fluids under rapid acceleration and high shear fields. These bubbles are geometrically similar to fracture surface patterns (Griffith crack model) existing in solids. Analogies between crack growth in solid and fluid cavitation are proposed and supported by analysis and observation (photographs). Healing phenomena (void condensation), well accepted in fluid mechanics, have been observed in some polymers and hypothesized in solid mechanics. By drawing on the strengths of the theories of solid mechanics and cavitation, a more complete unified theory can be developed.

Analogy between fluid cavitation and fracture mechanics

NASA Technical Reports Server (NTRS)

Hendricks, R. C.; Mullen, R. L.; Braun, M. J.

1983-01-01

When the stresses imposed on a fluid are sufficiently large, rupture or cavitation can occur. Such conditions can exist in many two-phase flow applications, such as the choked flows, which can occur in seals and bearings. Nonspherical bubbles with large aspect ratios have been observed in fluids under rapid acceleration and high shear fields. These bubbles are geometrically similar to fracture surface patterns (Griffith crack model) existing in solids. Analogies between crack growth in solid and fluid cavitation are proposed and supported by analysis and observation (photographs). Healing phenomena (void condensation), well accepted in fluid mechanics, have been observed in some polymers and hypothesized in solid mechanics. By drawing on the strengths of the theories of solid mechanics and cavitation, a more complete unified theory can be developed.

Particle-wall tribology of slippery hydrogel particle suspensions.

PubMed

Shewan, Heather M; Stokes, Jason R; Cloitre, Michel

2017-03-08

Slip is an important phenomenon that occurs during the flow of yield stress fluids like soft materials and pastes. Densely packed suspensions of hydrogel microparticles are used to show that slip is governed by the tribological interactions occurring between the samples and shearing surfaces. Both attractive/repulsive interactions between the dispersed particles and surface, as well as the viscoelasticity of the suspension, are found to play key roles in slip occurring within rheometric flows. We specifically discover that for two completely different sets of microgels, the sliding stress at which slip occurs scales with both the modulus of the particles and the bulk suspension modulus. This suggests that hysteresis losses within the viscoelastic particles contribute to friction forces and thus slip at the particle-surface tribo-contact. It is also found that slip during large amplitude oscillatory shear and steady shear flows share the same generic features.

Vacuum-assisted cell loading enables shear-free mammalian microfluidic culture

PubMed Central

Kolnik, Martin; Tsimring, Lev S; Hasty, Je

2012-01-01

Microfluidic perfusion cultures for mammalian cells provide a novel means for probing single-cell behavior but require the management of culture parameters such as flow-induced shear stress. Methods to eliminate shear stress generally focus on capturing cells in regions with high resistance to fluid flow. Here, we present a novel trapping design to easily and reliably load a high density of cells into culture chambers that are extremely isolated from potentially damaging flow effects. We utilize a transient on-chip vacuum to remove air from the culture chambers and rapidly replace the volume with a liquid cell suspension. We demonstrate the ability of this simple and robust method to load and culture three commonly used cell lines. We show how the incorporation of an on-chip function generator can be used for dynamic stimulation of cells during long-term continuous perfusion culture. PMID:22961584

The LS-STAG immersed boundary method for non-Newtonian flows in irregular geometries: flow of shear-thinning liquids between eccentric rotating cylinders

NASA Astrophysics Data System (ADS)

Botella, Olivier; Ait-Messaoud, Mazigh; Pertat, Adrien; Cheny, Yoann; Rigal, Claire

2015-04-01

This paper presents the extension of a well-established immersed boundary/cut-cell method, the LS-STAG method (Cheny and Botella in J Comput Phys 229:1043-1076, 2010), to non-Newtonian flow computations in 2D irregular geometries. One of the distinguished features of our IB method is to use level-set techniques in the cut-cells near the irregular boundary, where accurate discretization is of paramount importance for stability and accuracy of the computations. For this purpose, we present here an accurate discretization of the velocity gradients and shear rate in the cut-cells that fits elegantly in the framework of the velocity-pressure-stress staggered arrangement and the special quadratures developed previously for viscoelastic flows. After assessing the accuracy of the discretization on a benchmark solution for power-law fluids, the LS-STAG code is applied to the flow of various shear-thinning xanthan solutions in a wide-gap, non-coaxial, Taylor-Couette reactor for which rheological characterization, experimental flow measurements (PIV) and FLUENT simulations have recently been performed in our group. Our numerical investigation will give new insight on the flow patterns (onset, size and position of the recirculation zone) and will firmly correlate them to global flow properties such as shear-thinning index, generalized Reynolds number and torque ratio at the cylinders.

Coupling LAMMPS with Lattice Boltzmann fluid solver: theory, implementation, and applications

NASA Astrophysics Data System (ADS)

Tan, Jifu; Sinno, Talid; Diamond, Scott

2016-11-01

Studying of fluid flow coupled with solid has many applications in biological and engineering problems, e.g., blood cell transport, particulate flow, drug delivery. We present a partitioned approach to solve the coupled Multiphysics problem. The fluid motion is solved by the Lattice Boltzmann method, while the solid displacement and deformation is simulated by Large-scale Atomic/Molecular Massively Parallel Simulator (LAMMPS). The coupling is achieved through the immersed boundary method so that the expensive remeshing step is eliminated. The code can model both rigid and deformable solids. The code also shows very good scaling results. It was validated with classic problems such as migration of rigid particles, ellipsoid particle's orbit in shear flow. Examples of the applications in blood flow, drug delivery, platelet adhesion and rupture are also given in the paper. NIH.

Modeling the Inhomogeneous Response of Steady and Transient Flows of Entangled Micellar Solutions

NASA Astrophysics Data System (ADS)

McKinley, Gareth

2008-03-01

Surfactant molecules can self-assemble in solution into long flexible structures known as wormlike micelles. These structures entangle, forming a viscoelastic network similar to those in entangled polymer melts and solutions. However, in contrast to `inert' polymeric networks, wormlike micelles continuously break and reform leading to an additional relaxation mechanism and the name `living polymers'. Observations in both classes of entangled fluids have shown that steady and transient shearing flows of these solutions exhibit spatial inhomogeneities such as `shear-bands' at sufficiently large applied strains. In the present work, we investigate the dynamical response of a class of two-species elastic network models which can capture, in a self-consistent manner, the creation and destruction of elastically-active network segments, as well as diffusive coupling between the microstructural conformations and the local state of stress in regions with large spatial gradients of local deformation. These models incorporate a discrete version of the micellar breakage and reforming dynamics originally proposed by Cates and capture, at least qualitatively, non-affine tube deformation and chain disentanglement. The `flow curves' of stress and apparent shear rate resulting from an assumption of homogeneous deformation is non-monotonic and linear stability analysis shows that the region of non-monotonic response is unstable. Calculation of the full inhomogeneous flow field results in localized shear bands that grow linearly in extent across the gap as the apparent shear rate increases. Time-dependent calculations in step strain, large amplitude oscillatory shear (LAOS) and in start up of steady shear flow show that the velocity profile in the gap and the total stress measured at the bounding surfaces are coupled and evolve in a complex non-monotonic manner as the shear bands develop and propagate.

Non-Newtonian Hele-Shaw Flow and the Saffman-Taylor Instability

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kondic, L.; Shelley, M.J.; Palffy-Muhoray, P.

We explore the Saffman-Taylor instability of a gas bubble expanding into a shear thinning liquid in a radial Hele-Shaw cell. Using Darcy{close_quote}s law generalized for non-Newtonian fluids, we perform simulations of the full dynamical problem. The simulations show that shear thinning significantly influences the developing interfacial patterns. Shear thinning can suppress tip splitting, and produce fingers which oscillate during growth and shed side branches. Emergent length scales show reasonable agreement with a general linear stability analysis. {copyright} {ital 1998} {ital The American Physical Society}

Analysis of temporal shear stress gradients during the onset phase of flow over a backward-facing step.

PubMed

Haidekker, M A; White, C R; Frangos, J A

2001-10-01

Endothelial cells in blood vessels are exposed to bloodflow and thus fluid shear stress. In arterial bifurcations and stenoses, disturbed flow causes zones of recirculation and stagnation, which are associated with both spatial and temporal gradients of shear stress. Such gradients have been linked to the generation of atherosclerotic plaques. For in-vitro studies of endothelial cell responses, the sudden-expansion flow chamber has been widely used and described. A two-dimensional numerical simulation of the onset phase of flow through the chamber was performed. The wall shear stress action on the bottom plate was computed as a function of time and distance from the sudden expansion. The results showed that depending on the time for the flow to be established, significant temporal gradients occurred close to the second stagnation point of flow. Slowly ramping the flow over 15 s instead of 200 ms reduces the temporal gradients by a factor of 300, while spatial gradients are reduced by 23 percent. Thus, the effects of spatial and temporal gradients can be observed separately. In experiments on endothelial cells, disturbed flow stimulated cell proliferation only when flow onset was sudden. The spatial patterns of proliferation rate match the exposure to temporal gradients. This study provides information on the dynamics of spatial and temporal gradients to which the cells are exposed in a sudden-expansion flow chamber and relates them to changes in the onset phase of flow.

Computational modelling of the scaffold-free chondrocyte regeneration: a two-way coupling between the cell growth and local fluid flow and nutrient concentration.

PubMed

Hossain, Md Shakhawath; Bergstrom, D J; Chen, X B

2015-11-01

The in vitro chondrocyte cell culture process in a perfusion bioreactor provides enhanced nutrient supply as well as the flow-induced shear stress that may have a positive influence on the cell growth. Mathematical and computational modelling of such a culture process, by solving the coupled flow, mass transfer and cell growth equations simultaneously, can provide important insight into the biomechanical environment of a bioreactor and the related cell growth process. To do this, a two-way coupling between the local flow field and cell growth is required. Notably, most of the computational and mathematical models to date have not taken into account the influence of the cell growth on the local flow field and nutrient concentration. The present research aimed at developing a mathematical model and performing a numerical simulation using the lattice Boltzmann method to predict the chondrocyte cell growth without a scaffold on a flat plate placed inside a perfusion bioreactor. The model considers the two-way coupling between the cell growth and local flow field, and the simulation has been performed for 174 culture days. To incorporate the cell growth into the model, a control-volume-based surface growth modelling approach has been adopted. The simulation results show the variation of local fluid velocity, shear stress and concentration distribution during the culture period due to the growth of the cell phase and also illustrate that the shear stress can increase the cell volume fraction to a certain extent.

Fluid and element transfer at the slab-mantle interface: insights from the serpentinized Livingstone Fault, New Zealand

NASA Astrophysics Data System (ADS)

Smith, S. A. F.; Scott, J.; Tarling, M.; Tulley, C. J.; le Roux, P. J.

2017-12-01

At the slab-mantle interface in subduction zones, hydrous fluids released by dehydration reactions are fluxed upwards into the fore-arc mantle corner. The extent to which these fluids can move across the plate interface shear zone has significant implications for understanding the composition of the mantle wedge and the origin of episodic tremor and slow slip. The >1000 km long Livingstone Fault in New Zealand provides a superbly exposed analogue (both in terms of scale and the rock types involved) for the serpentinite shear zone likely to be present along the slab-mantle interface. The Livingstone Fault is a sheared serpentinite mélange up to several hundreds of meters wide that separates greenschist-facies quartzofeldspathic metasediments (e.g. analogue for slab sediments) from variably-serpentinized harzburgitic peridotite (e.g. analogue for mantle wedge). To track element mobility and paleo-fluid flow across the shear zone, Sr and Nd isotopes were measured in five transects across the metasediments, mélange and serpentinized peridotites. Results show that the mélange and serpentinized peridotites (originally with Sr and Nd similar to Permian MORB) were progressively overprinted with the isotopic composition of the metasediments at distances of up to c. 400 m from the mélange-metasediment contact. Mass balance calculations require that many elements were mobile across the mélange shear zone, but permeability modeling indicates that diffusive transfer of such elements is unrealistically slow. Instead, it appears that fluid and element percolation in to and across the mélange was aided by episodic over-pressuring and fracturing, as indicated by the widespread presence of tremolite-bearing breccias and veins that mutually cross-cut the serpentinite mélange fabrics. Overall, the field and isotopic results indicate that fluid and element redistribution within major serpentinite-bearing shear zones is strongly aided by fracturing and brecciation that are triggered by episodic fluid over-pressuring. By comparison to recent geophysical and experimental results, we infer that high fluid pressures and the resultant brittle failure processes may contribute to the slow slip and tremor signal near the forearc mantle corner.

Capture of endothelial cells under flow using immobilized vascular endothelial growth factor

PubMed Central

Smith, Randall J.; Koobatian, Maxwell T.; Shahini, Aref; Swartz, Daniel D.; Andreadis, Stelios T.

2015-01-01

We demonstrate the ability of immobilized vascular endothelial growth factor (VEGF) to capture endothelial cells (EC) with high specificity under fluid flow. To this end, we engineered a surface consisting of heparin bound to poly-L-lysine to permit immobilization of VEGF through the C-terminal heparin-binding domain. The immobilized growth factor retained its biological activity as shown by proliferation of EC and prolonged activation of KDR signaling. Using a microfluidic device we assessed the ability to capture EC under a range of shear stresses from low (0.5 dyne/cm2) to physiological (15 dyne/cm2). Capture was significant for all shear stresses tested. Immobilized VEGF was highly selective for EC as evidenced by significant capture of human umbilical vein and ovine pulmonary artery EC but no capture of human dermal fibroblasts, human hair follicle derived mesenchymal stem cells, or mouse fibroblasts. Further, VEGF could capture EC from mixtures with non-EC under low and high shear conditions as well as from complex fluids like whole human blood under high shear. Our findings may have far reaching implications, as they suggest that VEGF could be used to promote endothelialization of vascular grafts or neovascularization of implanted tissues by rare but continuously circulating EC. PMID:25771020

Toward a unifying constitutive relation for sediment transport across environments

NASA Astrophysics Data System (ADS)

Houssais, Morgane; Jerolmack, Douglas J.

2017-01-01

Landscape evolution models typically parse the environment into different process domains, each with its own sediment transport law: e.g., soil creep, landslides and debris flows, and river bed-load and suspended-sediment transport. Sediment transport in all environments, however, contains many of the same physical ingredients, albeit in varying proportions: grain entrainment due to a shear force, that is a combination of fluid flow, particle-particle friction and gravity. We present a new take on the perspective originally advanced by Bagnold, that views the long profile of a hillsope-river-shelf system as a continuous gradient of decreasing granular friction dominance and increasing fluid drag dominance on transport capacity. Recent advances in understanding the behavior and regime transitions of dense granular systems suggest that the entire span of granular-to-fluid regimes may be accommodated by a single-phase rheology. This model predicts a material-flow effective friction (or viscosity) that changes with the degree of shear rate and confining pressure. We present experimental results confirming that fluid-driven sediment transport follows this same rheology, for bed and suspended load. Surprisingly, below the apparent threshold of motion we observe that sediment particles creep, in a manner characteristic of glassy systems. We argue that this mechanism is relevant for both hillslopes and rivers. We discuss the possibilities of unifying sediment transport across environments and disciplines, and the potential consequences for modeling landscape evolution.

Computational fluid modeling and performance analysis of a bidirectional rotating perfusion culture system.

PubMed

Kang, Chang-Wei; Wang, Yan; Tania, Marshella; Zhou, Huancheng; Gao, Yi; Ba, Te; Tan, Guo-Dong Sean; Kim, Sangho; Leo, Hwa Liang

2013-01-01

A myriad of bioreactor configurations have been investigated as extracorporeal medical support systems for temporary replacement of vital organ functions. In recent years, studies have demonstrated that the rotating bioreactors have the potential to be utilized as bioartificial liver assist devices (BLADs) owing to their advantage of ease of scalability of cell-culture volume. However, the fluid movement in the rotating chamber will expose the suspended cells to unwanted flow structures with abnormally high shear conditions that may result in poor cell stability and in turn lower the efficacy of the bioreactor system. In this study, we compared the hydrodynamic performance of our modified rotating bioreactor design with that of an existing rotating bioreactor design. Computational fluid dynamic analysis coupled with experimental results were employed in the optimization process for the development of the modified bioreactor design. Our simulation results showed that the modified bioreactor had lower fluid induced shear stresses and more uniform flow conditions within its rotating chamber than the conventional design. Experimental results revealed that the cells within the modified bioreactor also exhibited better cell-carrier attachment, higher metabolic activity, and cell viability compared to those in the conventional design. In conclusion, this study was able to provide important insights into the flow physics within the rotating bioreactors, and help enhanced the hydrodynamic performance of an existing rotating bioreactor for BLAD applications. © 2013 American Institute of Chemical Engineers.

The Effect of Impeller Type on Floc Size and Structure during Shear-Induced Flocculation

PubMed

Spicer; Keller; Pratsinis

1996-12-01

The effect of impeller type and shear rate on the evolution of floc size and structure during shear-induced flocculation of polystyrene particles with aluminum sulfate is investigated by image analysis. One radial flow (six-blade Rushton turbine) and two axial flow (three-blade fluid foil, four-blade 45° pitch) impeller configurations are examined. The steady state average floc size is shown to depend on the frequency of recirculation to the impeller zone and its characteristic velocity gradient. The concepts of fractal geometry are used to characterize the floc structure. For all impellers, the two-dimensional floc fractal dimension, Dpf, increases during floc growth, indicating formation of more open structures. Later on, Dpf levels off at a steady state value as breakage becomes significant and the floc size distribution approaches steady state. The shear rate does not affect the steady state Dpf of the flocs within experimental uncertainty.

A Computational Study of Shear Layer Receptivity

NASA Astrophysics Data System (ADS)

Barone, Matthew; Lele, Sanjiva

2002-11-01

The receptivity of two-dimensional, compressible shear layers to local and external excitation sources is examined using a computational approach. The family of base flows considered consists of a laminar supersonic stream separated from nearly quiescent fluid by a thin, rigid splitter plate with a rounded trailing edge. The linearized Euler and linearized Navier-Stokes equations are solved numerically in the frequency domain. The flow solver is based on a high order finite difference scheme, coupled with an overset mesh technique developed for computational aeroacoustics applications. Solutions are obtained for acoustic plane wave forcing near the most unstable shear layer frequency, and are compared to the existing low frequency theory. An adjoint formulation to the present problem is developed, and adjoint equation calculations are performed using the same numerical methods as for the regular equation sets. Solutions to the adjoint equations are used to shed light on the mechanisms which control the receptivity of finite-width compressible shear layers.

Hemodynamically driven stent strut design.

PubMed

Jiménez, Juan M; Davies, Peter F

2009-08-01

Stents are deployed to physically reopen stenotic regions of arteries and to restore blood flow. However, inflammation and localized stent thrombosis remain a risk for all current commercial stent designs. Computational fluid dynamics results predict that nonstreamlined stent struts deployed at the arterial surface in contact with flowing blood, regardless of the strut height, promote the creation of proximal and distal flow conditions that are characterized by flow recirculation, low flow (shear) rates, and prolonged particle residence time. Furthermore, low shear rates yield an environment less conducive for endothelialization, while local flow recirculation zones can serve as micro-reaction chambers where procoagulant and pro-inflammatory elements from the blood and vessel wall accumulate. By merging aerodynamic theory with local hemodynamic conditions we propose a streamlined stent strut design that promotes the development of a local flow field free of recirculation zones, which is predicted to inhibit thrombosis and is more conducive for endothelialization.

Two-Phase Flow and Compaction Within and Outside a Sphere under Pure Shear

NASA Astrophysics Data System (ADS)

Hier-Majumder, S.

2017-12-01

This work presents a framework for building analytical solutions for coupled flow in two interacting multiphase domains. The coupled system consists of a multiphase sphere embedded in a multiphase substrate. Each of these domains consist of an interconnected load bearing matrix phase and an inviscid interstitial fluid phase. This work outlines techniques for building analytical solutions for velocity, pressure, and compaction within each domain, subject to boundary conditions of continuity of matrix velocity and normal traction at the interface between the two domains. The solutions indicate that the flow is strongly dependent on the ratio of shear viscosities between the matrix phase in the sphere and the matrix phase in the substrate. When deformed under a pure shear deformation, the magnitude of flow within the sphere rapidly decreases with an increase in this ratio until it reaches a value of 40, after which, the velocity within the sphere becomes relatively insensitive to the increase in the viscosity contrast.

Astrophysical Flows

NASA Astrophysics Data System (ADS)

Pringle, James E.; King, Andrew

2003-07-01

Almost all conventional matter in the Universe is fluid, and fluid dynamics plays a crucial role in astrophysics. This new graduate textbook provides a basic understanding of the fluid dynamical processes relevant to astrophysics. The mathematics used to describe these processes is simplified to bring out the underlying physics. The authors cover many topics, including wave propagation, shocks, spherical flows, stellar oscillations, the instabilities caused by effects such as magnetic fields, thermal driving, gravity, shear flows, and the basic concepts of compressible fluid dynamics and magnetohydrodynamics. The authors are Directors of the UK Astrophysical Fluids Facility (UKAFF) at the University of Leicester, and editors of the Cambridge Astrophysics Series. This book has been developed from a course in astrophysical fluid dynamics taught at the University of Cambridge. It is suitable for graduate students in astrophysics, physics and applied mathematics, and requires only a basic familiarity with fluid dynamics.• Provides coverage of the fundamental fluid dynamical processes an astrophysical theorist needs to know • Introduces new mathematical theory and techniques in a straightforward manner • Includes end-of-chapter problems to illustrate the course and introduce additional ideas

Chemotactic Motility of Sperm in Shear

NASA Astrophysics Data System (ADS)

Guasto, Jeffrey S.; Riffell, Jeffrey A.; Zimmer, Richard K.; Stocker, Roman

2011-11-01

Chemical gradients are utilized by plants and animals in sexual reproduction to guide swimming sperm cells toward the egg. This process (``chemotaxis''), which can greatly increase the success of fertilization, is subject to interference by fluid flow, both in the bodily conduits of internal fertilizers (e.g. mammals) and in the aquatic environment of external fertilizers (e.g. benthic invertebrates). We studied the biomechanics of chemotaxing sea urchin spermatozoa using microfluidic devices, which allow for the precise and independent control of attractant gradients and fluid shear. We captured swimming trajectories and flagellar beat patterns using high-speed video-microscopy, to detect chemotactic responses and measure the effect of fluid forces on swimming. This work will ultimately help us to understand how swimming sperm cells actively navigate natural chemoattractant gradients for successful fertilization.

Progress and supercomputing in computational fluid dynamics; Proceedings of U.S.-Israel Workshop, Jerusalem, Israel, December 1984

NASA Technical Reports Server (NTRS)

Murman, E. M. (Editor); Abarbanel, S. S. (Editor)

1985-01-01

Current developments and future trends in the application of supercomputers to computational fluid dynamics are discussed in reviews and reports. Topics examined include algorithm development for personal-size supercomputers, a multiblock three-dimensional Euler code for out-of-core and multiprocessor calculations, simulation of compressible inviscid and viscous flow, high-resolution solutions of the Euler equations for vortex flows, algorithms for the Navier-Stokes equations, and viscous-flow simulation by FEM and related techniques. Consideration is given to marching iterative methods for the parabolized and thin-layer Navier-Stokes equations, multigrid solutions to quasi-elliptic schemes, secondary instability of free shear flows, simulation of turbulent flow, and problems connected with weather prediction.

Fallon, Nevada FORGE Analogue Outcrop Samples

DOE Data Explorer

Blankenship, Doug; Bauer, Steve J.; Barrow, P.; Robbins, A.; Hileman, M.

2018-03-12

Compilation of results for mechanical and fluid flow properties of analogue outcrop samples - experimental data for compressional and shear wave velocities, tensile strengths, and compressive strengths. Outcrop location and sample orientation data are documented in a separate csv file.